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Search of human proteins with 134133246
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|134133246 hypothetical protein LOC285753 [Homo sapiens]
(460 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|134133246 hypothetical protein LOC285753 [Homo sapiens] 917 0.0
gi|28603844 hypothetical protein LOC285753 [Homo sapiens] 917 0.0
gi|45430055 translokin [Homo sapiens] 242 6e-64
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 67 4e-11
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 62 1e-09
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 60 5e-09
gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens] 60 5e-09
gi|58530840 desmoplakin isoform I [Homo sapiens] 59 7e-09
gi|118498362 kinectin 1 isoform b [Homo sapiens] 59 9e-09
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 59 9e-09
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 59 9e-09
gi|55770834 centromere protein F [Homo sapiens] 59 9e-09
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 59 1e-08
gi|64085252 hypothetical protein LOC145508 [Homo sapiens] 59 1e-08
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 59 1e-08
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 58 2e-08
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 58 2e-08
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 58 2e-08
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 58 2e-08
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 58 2e-08
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 57 4e-08
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 57 4e-08
gi|237858621 polyamine modulated factor 1 binding protein 1 isof... 56 6e-08
gi|237858619 polyamine modulated factor 1 binding protein 1 isof... 56 6e-08
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 56 6e-08
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 55 1e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 55 1e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 55 1e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 55 1e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 55 1e-07
>gi|134133246 hypothetical protein LOC285753 [Homo sapiens]
Length = 460
Score = 917 bits (2371), Expect = 0.0
Identities = 460/460 (100%), Positives = 460/460 (100%)
Query: 1 MDSELMHSIVGSYHKPPERVFVPSFTQNEPSQNCHPANLEVTSPKILHSPNSQALILALK 60
MDSELMHSIVGSYHKPPERVFVPSFTQNEPSQNCHPANLEVTSPKILHSPNSQALILALK
Sbjct: 1 MDSELMHSIVGSYHKPPERVFVPSFTQNEPSQNCHPANLEVTSPKILHSPNSQALILALK 60
Query: 61 TLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS 120
TLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS
Sbjct: 61 TLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS 120
Query: 121 SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEK 180
SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEK
Sbjct: 121 SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEK 180
Query: 181 ECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHS 240
ECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHS
Sbjct: 181 ECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHS 240
Query: 241 KEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPS 300
KEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPS
Sbjct: 241 KEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPS 300
Query: 301 RTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDI 360
RTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDI
Sbjct: 301 RTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDI 360
Query: 361 ECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIK 420
ECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIK
Sbjct: 361 ECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIK 420
Query: 421 NSPRKCLTDTNLFQKNSSFHPIRVHNLQMKLRRDDIMWEQ 460
NSPRKCLTDTNLFQKNSSFHPIRVHNLQMKLRRDDIMWEQ
Sbjct: 421 NSPRKCLTDTNLFQKNSSFHPIRVHNLQMKLRRDDIMWEQ 460
>gi|28603844 hypothetical protein LOC285753 [Homo sapiens]
Length = 460
Score = 917 bits (2371), Expect = 0.0
Identities = 460/460 (100%), Positives = 460/460 (100%)
Query: 1 MDSELMHSIVGSYHKPPERVFVPSFTQNEPSQNCHPANLEVTSPKILHSPNSQALILALK 60
MDSELMHSIVGSYHKPPERVFVPSFTQNEPSQNCHPANLEVTSPKILHSPNSQALILALK
Sbjct: 1 MDSELMHSIVGSYHKPPERVFVPSFTQNEPSQNCHPANLEVTSPKILHSPNSQALILALK 60
Query: 61 TLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS 120
TLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS
Sbjct: 61 TLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS 120
Query: 121 SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEK 180
SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEK
Sbjct: 121 SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEK 180
Query: 181 ECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHS 240
ECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHS
Sbjct: 181 ECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHS 240
Query: 241 KEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPS 300
KEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPS
Sbjct: 241 KEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPS 300
Query: 301 RTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDI 360
RTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDI
Sbjct: 301 RTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDI 360
Query: 361 ECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIK 420
ECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIK
Sbjct: 361 ECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIK 420
Query: 421 NSPRKCLTDTNLFQKNSSFHPIRVHNLQMKLRRDDIMWEQ 460
NSPRKCLTDTNLFQKNSSFHPIRVHNLQMKLRRDDIMWEQ
Sbjct: 421 NSPRKCLTDTNLFQKNSSFHPIRVHNLQMKLRRDDIMWEQ 460
>gi|45430055 translokin [Homo sapiens]
Length = 500
Score = 242 bits (617), Expect = 6e-64
Identities = 146/403 (36%), Positives = 225/403 (55%), Gaps = 33/403 (8%)
Query: 51 NSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIK 110
NS+A+ ALK LQ+KI RLELER QAE+++ LSRE +YKK L+ + ER + E K
Sbjct: 65 NSRAIFSALKNLQDKIRRLELERIQAEESVKTLSRETIEYKKVLDEQIQERENSKNEESK 124
Query: 111 QKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYA 170
++++ QL +A+++C LLEKQLEY + M+ + E E+ +LE+Q L+RE++ DQ + +
Sbjct: 125 HNQELTSQLLAAENKCNLLEKQLEYMRNMIKHAEMERTSVLEKQVSLERERQHDQTHVQS 184
Query: 171 KLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKII 230
+LEKLD+LE+E +LTT Q AE K++ LE KL EEE +RK Q KA+ELQTGLE +++I
Sbjct: 185 QLEKLDLLEQEYNKLTTMQALAEKKMQELEAKLHEEEQERKRMQAKAAELQTGLETNRLI 244
Query: 231 MSS-----VSNLKHSKEKKKSSKKTKCIKR----RPPWQICSKFGALPFVAEK------- 274
V N + K+KK + K + +P +++C G +PFVA K
Sbjct: 245 FEDKATPCVPNARRIKKKKSKPPEKKSSRNYFGAQPHYRLC--LGDMPFVAGKSTSPSHA 302
Query: 275 -----------MRQHRDPHILQKPFN-VTETRCLPKPSRTTSWCKAIPPDSEKSISICDN 322
M+QH + N + + + + PP S I +
Sbjct: 303 VVANVQLVLHLMKQHSKALCNDRVINSIPLAKQVSSRGGKSKKLSVTPPSSN---GINEE 359
Query: 323 LSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLK 382
LSE+L +QDE QMS +HQ+L K ++E+ + + D +ECELE L+ +ME K QI+K++
Sbjct: 360 LSEVLQTLQDEFGQMSFDHQQLAKLIQESPTVELKDKLECELEALVGRMEAKANQITKVR 419
Query: 383 KHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRK 425
K+Q + K + + Q ++ E+ I + K
Sbjct: 420 KYQAQLEKQKLEKQKKELKATKKTLDEERNSSSRSGITGTTNK 462
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 66.6 bits (161), Expect = 4e-11
Identities = 81/364 (22%), Positives = 161/364 (44%), Gaps = 59/364 (16%)
Query: 53 QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENE----------TNERN 102
Q LI L+ ++++H LE++ T + S+E K LENE N+ +
Sbjct: 465 QELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLS 524
Query: 103 LAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKE 162
L ++EL ++ D++++L + Q +KQ E + + N++ + + + ++ E +
Sbjct: 525 LENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELK 584
Query: 163 QDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKE----------EEHQRKL 212
Q + ++ KL+K E+ C L +K E+K K++EE +E E Q +
Sbjct: 585 QKRDEVKCKLDK---SEENCNNL---RKQVENKNKYIEELQQENKALKKKGTAESKQLNV 638
Query: 213 FQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVA 272
++ K ++L+ LE +K +++ + + K + ++
Sbjct: 639 YEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEE----------------V 682
Query: 273 EKMRQHRDPHI-LQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQ 331
EK + D + LQK + RC K + + + +K I D SEL +
Sbjct: 683 EKAKVIADEAVKLQKEI---DKRCQHKIAEMVALMEKHKHQYDKIIEERD--SELGLYKS 737
Query: 332 DELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKH-QDSVCK 390
E +Q S L+ E E +++ EL + K++EI+ E+ KLK+ +++
Sbjct: 738 KEQEQSS------LRASLEIE----LSNLKAELLSVKKQLEIEREEKEKLKREAKENTAT 787
Query: 391 LQQK 394
L++K
Sbjct: 788 LKEK 791
Score = 58.2 bits (139), Expect = 2e-08
Identities = 56/216 (25%), Positives = 103/216 (47%), Gaps = 18/216 (8%)
Query: 38 NLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALEN- 96
N E+TS + L L K L ++ + LE ++++N ++ + K +EN
Sbjct: 513 NTELTS-------HCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENL 565
Query: 97 ---ETNERNLAH--QELIKQKKD-ISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMI 150
ET RN +E +KQK+D + +L ++ C L KQ+E + + +++E +
Sbjct: 566 QETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKAL 625
Query: 151 LEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTT-QKTAEDKIKHLEEKLKEEEHQ 209
++ ++ ++K+ +L+ +++ +T T QK EDK K EE L EE +
Sbjct: 626 KKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDK-KISEENLLEEVEK 684
Query: 210 RKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKK 245
K+ D+A +LQ EI K ++ + EK K
Sbjct: 685 AKVIADEAVKLQK--EIDKRCQHKIAEMVALMEKHK 718
Score = 44.7 bits (104), Expect = 2e-04
Identities = 94/418 (22%), Positives = 160/418 (38%), Gaps = 108/418 (25%)
Query: 51 NSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENET---------NER 101
NS+ L L ++ +++ + E L + + +K +E + NE+
Sbjct: 98 NSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEK 157
Query: 102 -NLAHQELIKQKKDISIQLSSAQSRCTLLE----------KQLEYTKR------MVLNVE 144
+L +E I++ KD+ + ++ + C LL+ K+ EY + M LN
Sbjct: 158 VSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNN 217
Query: 145 REKNMILEQQAQLQREKEQDQM--KLYAKLEKLDVLEKECFR------------------ 184
EK + ++ ++Q E + +M KL EK+ LE+E +
Sbjct: 218 IEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITE 277
Query: 185 -------LTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKI-IMSSVSN 236
LT + + DK+ LEEK K + K +K L LE K+ + SVS
Sbjct: 278 KENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVST 337
Query: 237 LKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCL 296
K +E + + KT IC E+ + R H F VTE
Sbjct: 338 QKALEEDLQIATKT----------ICQLTEEKETQMEESNKARAAH----SFVVTEFE-- 381
Query: 297 PKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDEL----DQMSMEHQELLKQMKETE 352
T+ C +L ELL Q L DQ+ + EL K+ E E
Sbjct: 382 ------TTVC---------------SLEELLRTEQQRLEKNEDQLKILTMELQKKSSELE 420
Query: 353 SHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMS-EASGIQQE 409
E+ L E++ E++ K+ ++++ L + Q K++ E G +QE
Sbjct: 421 ----------EMTKLTNNKEVELEELKKVLGEKETL--LYENKQFEKIAEELKGTEQE 466
Score = 42.7 bits (99), Expect = 7e-04
Identities = 80/363 (22%), Positives = 151/363 (41%), Gaps = 69/363 (19%)
Query: 64 EKIHRLELERTQA-EDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSA 122
E++ R E +R + ED L IL+ E + LE T N EL + KK +
Sbjct: 388 EELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLG------ 441
Query: 123 QSRCTLL--EKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEK 180
+ TLL KQ E + E+E +L+ REKE + LE
Sbjct: 442 -EKETLLYENKQFEKIAEELKGTEQELIGLLQ-----AREKE------------VHDLEI 483
Query: 181 ECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQ-TGLEISKIIMSSVSNLKH 239
+ +TT+++ ++K L+ +L+ E+ + ++L E+++ LK+
Sbjct: 484 QLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKN 543
Query: 240 SKE-----KKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETR 294
+E KK+ + K I+ + + L +V E+++Q RD E +
Sbjct: 544 QQEDINNNKKQEERMLKQIENLQETETQLR-NELEYVREELKQKRD-----------EVK 591
Query: 295 CLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLK----QMKE 350
C +KS C+NL + + ++++ E++ L K + K+
Sbjct: 592 C----------------KLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQ 635
Query: 351 TESHSV-CDDIECELECLLKKM-EIKGEQISKLKKHQDSVCKLQQKVQNSKM--SEASGI 406
+ + + +E ELE +K EI +++ + S L ++V+ +K+ EA +
Sbjct: 636 LNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKL 695
Query: 407 QQE 409
Q+E
Sbjct: 696 QKE 698
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 62.0 bits (149), Expect = 1e-09
Identities = 88/409 (21%), Positives = 164/409 (40%), Gaps = 35/409 (8%)
Query: 22 VPSFTQNEPSQNCHPANLEVTSPKILHSPNS-QALILALKTLQEKIHRLELERTQAEDNL 80
V S Q+E H LEV K L Q ++ LK L E+ R E T L
Sbjct: 1122 VNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTS---KL 1178
Query: 81 NILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMV 140
E K + E E K ++++IQL C E LE +
Sbjct: 1179 KTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDIC---CKKTEALLEAKTNEL 1235
Query: 141 LNVEREK-NMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHL 199
+N+ K N IL + + Q + + L K + LE + +LT Q T +
Sbjct: 1236 INISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQA 1295
Query: 200 EEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPW 259
+L+E+E+Q K + L T E + + +++ +S+K CI +
Sbjct: 1296 THQLEEKENQIKSMKADIESLVTEKEALQ--------KEGGNQQQAASEKESCITQLKK- 1346
Query: 260 QICSKFGALPFVAEKMRQHR-----------DPHI-LQKPFNVTETRCLPKPSRTT---S 304
++ A+ + E++++ + D ++ LQ +++E R
Sbjct: 1347 ELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEE 1406
Query: 305 WCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLK--QMKETESHSVCDDIEC 362
C+ + + S + D LS+ ++ +++D S + E K Q + T+ + +++
Sbjct: 1407 KCELLDQVQDLSFKV-DTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQI 1465
Query: 363 ELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDS 411
+LE K+ K EQI+ LK+ D K ++ + S +++++S
Sbjct: 1466 QLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKES 1514
Score = 60.1 bits (144), Expect = 4e-09
Identities = 69/385 (17%), Positives = 169/385 (43%), Gaps = 41/385 (10%)
Query: 59 LKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQ 118
+K LQ ++ E + ++ +N+L E Q K + E ++ K++ ++ +
Sbjct: 1460 VKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETE 1519
Query: 119 LSSAQSRCTLLEK-------QLEYTKRMVLNVEREKNM----ILEQQAQLQREKEQDQMK 167
L S +R LE ++E ++ N ++K++ ++++ Q E+ +
Sbjct: 1520 LKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNR 1579
Query: 168 LYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEIS 227
+ EK+ LE + + + +T + +++H+ +K +E + K +D+ +
Sbjct: 1580 VKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDR---------LE 1630
Query: 228 KIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAE----KMRQHRDPHI 283
+ ++ LK E+K ++ K + + + + K G ++E + R+ HI
Sbjct: 1631 SESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHI 1690
Query: 284 LQKPF-----NVTETRCLPKPSR-TTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQM 337
L++ + +ET +P+ ++ ++ + DS+ + E + +Q L
Sbjct: 1691 LEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ--KTYEEKISVLQRNL--- 1745
Query: 338 SMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDS--VCKLQQKV 395
E ++LL+++ + + +V E+ C ++ IK E ++ K+H+D + LQ+++
Sbjct: 1746 -TEKEKLLQRVGQEKEETVSSHF--EMRCQYQERLIKLEH-AEAKQHEDQSMIGHLQEEL 1801
Query: 396 QNSKMSEASGIQQEDSYPKGSKNIK 420
+ + + Q G NI+
Sbjct: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQ 1826
Score = 54.7 bits (130), Expect = 2e-07
Identities = 91/391 (23%), Positives = 165/391 (42%), Gaps = 52/391 (13%)
Query: 59 LKTLQEK-------IHRLELER----TQAEDNLNILSREAAQYK-KALENETN-ERNLAH 105
LK QEK + LEL++ T++E+ L L +EA Y+ + LE E++ E++L
Sbjct: 523 LKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSL-- 580
Query: 106 QELIKQKKDISIQLSSAQSR-----CTLLEK---QLEYTKRMVLNVEREKNMILEQQAQL 157
QE Q KD+++ L + +++ ++EK +LE K + EK +L+QQ Q
Sbjct: 581 QENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQT 640
Query: 158 QREK-----EQDQMKLYAKLEKL------DVLEKECFRLTTTQKTAEDKIKHLEEKLKEE 206
+ EK EQ++ L E + ++ EK +L Q E L E LK
Sbjct: 641 EMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKAR 700
Query: 207 ---EHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICS 263
E + + +D+ +++ LE M N H ++ K+ + +R +
Sbjct: 701 HKLEEELSVLKDQTDKMKQELEAK---MDEQKN-HHQQQVDSIIKEHEVSIQRTEKALKD 756
Query: 264 KFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDN- 322
+ L E + + RD H+ + +V K S + D +S +
Sbjct: 757 QINQL----ELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHE 812
Query: 323 ----LSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQI 378
E L +Q +L + E L KQ+ E E+ D+ EL+ +++ +Q+
Sbjct: 813 QTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQK--KDVCTELDAHKIQVQDLMQQL 870
Query: 379 SKLKKHQDSVCKLQQKVQNSKMSEASGIQQE 409
K + K +V SK+ + + Q++
Sbjct: 871 EKQNSEMEQKVKSLTQVYESKLEDGNKEQEQ 901
Score = 53.1 bits (126), Expect = 5e-07
Identities = 74/358 (20%), Positives = 162/358 (45%), Gaps = 48/358 (13%)
Query: 63 QEKIHRLELERTQAEDNLNI-LSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSS 121
QE +L+ + ++ + + L + ++Y K + + + +LA +EL QKK I L+
Sbjct: 494 QELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAI---LTE 550
Query: 122 AQSRCTLLEKQLEYTKRMVLNVE--------REKNMILEQQAQLQREKEQDQMKLYAKLE 173
++++ L+++ E + +L +E KN + L+ EK + ++ +E
Sbjct: 551 SENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVE 610
Query: 174 K----LDVLEKECFRLTTTQ-KTAEDKIKHLEEKLKEEEHQRK--LFQDKASELQTGLEI 226
K L+ L+ + L T + + + + + EKL+E+ Q K L +DK Q +E
Sbjct: 611 KHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE 670
Query: 227 SKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQK 286
++K ++ + SS+ ++ +K R + + L +KM+Q
Sbjct: 671 MNEKTLEKLDVKQTELESLSSELSEVLKARHKLE--EELSVLKDQTDKMKQE-------- 720
Query: 287 PFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLK 346
E + + + +I + E SI + A++D+++Q+ + +E K
Sbjct: 721 ----LEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEK------ALKDQINQLELLLKERDK 770
Query: 347 QMKETESH--SVCDDI---ECELECLLKKMEI----KGEQISKLKKHQDSVCKLQQKV 395
+KE ++H ++ DI E EL+ K+++ + + K +++ + +LQQK+
Sbjct: 771 HLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKL 828
Score = 46.6 bits (109), Expect = 5e-05
Identities = 100/442 (22%), Positives = 187/442 (42%), Gaps = 98/442 (22%)
Query: 59 LKTLQEKIHRLELERTQAEDNLNIL-SREAAQYK--------------KALENETNERNL 103
++ L+ I R E E QA L++ S ++A ++ K L+ ET L
Sbjct: 779 VENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILL 838
Query: 104 AHQ--ELIKQKKDISIQLSS----AQSRCTLLEKQ------------------------- 132
Q E+ QKKD+ +L + Q LEKQ
Sbjct: 839 TKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKE 898
Query: 133 LEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTA 192
E TK+++ VE+E NMIL+ + ++E E KL AK + + +L +E T K
Sbjct: 899 QEQTKQIL--VEKE-NMILQMREGQKKEIEILTQKLSAKEDSIHILNEE---YETKFKNQ 952
Query: 193 EDKIKHLEEKLKE-EEHQRKLFQDKASELQ-----TGLEISKI----------------- 229
E K++ +++K KE +E +K D+ ++L+ T LE+S+
Sbjct: 953 EKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSA 1012
Query: 230 -IMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPF 288
I +VS L+ + +K++ T+ +R I L AE++++ + + +K
Sbjct: 1013 GISDAVSRLE-TNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQ 1071
Query: 289 NVTETR-------C-LPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSME 340
V E + C + ++ +W K E+ + L+EL Q++L Q S
Sbjct: 1072 EVAELKQKILLFGCEKEEMNKEITWLK------EEGVKQDTTLNEL----QEQLKQKSAH 1121
Query: 341 HQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKK-HQDSVCKLQQKVQNSK 399
L + + ++H + +E +L LK+ EQ+ +LK ++ K+ + K
Sbjct: 1122 VNSLAQDETKLKAH--LEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLK 1179
Query: 400 MSEASGIQQEDSYPKGSKNIKN 421
++ + S+ K +K++++
Sbjct: 1180 TTDEEFQSLKSSHEKSNKSLED 1201
Score = 45.4 bits (106), Expect = 1e-04
Identities = 69/358 (19%), Positives = 155/358 (43%), Gaps = 44/358 (12%)
Query: 60 KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLA--HQELIKQ------ 111
KT +E+ L+ E ++ + + + +++++ + A + +E+ LA QEL K+
Sbjct: 446 KTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRER 505
Query: 112 --KKDISIQLSSAQSRCTLLEKQLEYTKRMVL-NVEREKNMILEQQAQLQREKEQDQMKL 168
++ + + L +QS + ++ E + + L +E +K IL + R+ +Q+
Sbjct: 506 EFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETY 565
Query: 169 YAKLEKLD-VLEKECFRLTTTQKTAEDKIKHLE-EKLKEEEHQRKLFQDKASELQT-GLE 225
++ +L+ LEK L + ++D HLE EK K + + + +EL++ +
Sbjct: 566 RTRILELESSLEKS---LQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQ 622
Query: 226 ISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHIL- 284
+ + LK + + + KC + EK +D I+
Sbjct: 623 QDALWTEKLQVLKQQYQTEMEKLREKCEQ------------------EKETLLKDKEIIF 664
Query: 285 QKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQEL 344
Q + L K + +++ + + + L E L ++D+ D+M QEL
Sbjct: 665 QAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK---QEL 721
Query: 345 LKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSE 402
+M E ++H + +++ ++K+ E+ ++ K K Q + +L K ++ + E
Sbjct: 722 EAKMDEQKNHH-----QQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKE 774
Score = 45.1 bits (105), Expect = 1e-04
Identities = 83/433 (19%), Positives = 173/433 (39%), Gaps = 48/433 (11%)
Query: 29 EPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKI--HRLELERTQAEDNLNILSRE 86
E +N H N E+T H ++L K Q+ + +L++ + Q + + L +
Sbjct: 595 EAEKNKH--NKEITVMVEKHKTELESL----KHQQDALWTEKLQVLKQQYQTEMEKLREK 648
Query: 87 AAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVERE 146
Q K+ L + AH E + +K +L Q+ L +L + +E E
Sbjct: 649 CEQEKETLLKDKEIIFQAHIEEMNEKT--LEKLDVKQTELESLSSELSEVLKARHKLEEE 706
Query: 147 KNMILEQQAQLQREKE--QDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLK 204
+++ +Q ++++E E D+ K + + + ++++ + T+K +D+I LE LK
Sbjct: 707 LSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLK 766
Query: 205 EEEHQRKLFQDKASELQTGLEISK----------IIMSSVSNLKHSKEKKKSSKKTKCIK 254
E + K Q L+ ++ S+ + S + H + K + + +
Sbjct: 767 ERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQ 826
Query: 255 RRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSE 314
+ + + VAE Q +D + + + + S +
Sbjct: 827 KLLDLE-TERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME----QKV 881
Query: 315 KSIS-ICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEI 373
KS++ + ++ E Q++ Q+ +E + ++ QM+E + E+E L +K+
Sbjct: 882 KSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKK--------EIEILTQKLSA 933
Query: 374 KGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQE------DSYPKGSKNIKNSPRKCL 427
K + I L + ++ K Q+K +A +Q+ D K K ++N
Sbjct: 934 KEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELEN------ 987
Query: 428 TDTNLFQKNSSFH 440
T L QK F+
Sbjct: 988 TALELSQKEKQFN 1000
Score = 44.3 bits (103), Expect = 2e-04
Identities = 101/423 (23%), Positives = 174/423 (41%), Gaps = 35/423 (8%)
Query: 26 TQNEPSQNCHPANLEVTSPKILHSPNSQALILALKTLQ-EKIHRL-ELERTQAEDNLNIL 83
T E SQ N ++ +S + L+T Q E+I L E+ R + D ++I
Sbjct: 988 TALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIW 1047
Query: 84 SREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNV 143
++ Q + L+ E +E L +E + I L + + K++ + K +
Sbjct: 1048 EKKLNQQAEELQ-EIHEIQLQEKEQEVAELKQKILLFGCEKE--EMNKEITWLKEEGVKQ 1104
Query: 144 EREKNMILEQQAQLQREKE---QDQMKLYAKLEKLDV-LEKECFRLTTTQKTAEDKIKHL 199
+ N + EQ Q QD+ KL A LEKL+V L K T Q+ + +
Sbjct: 1105 DTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQE------QLV 1158
Query: 200 EEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPW 259
E K+ EE +RK+ + S+L+T E + + SS S E K K +
Sbjct: 1159 ELKMLAEEDKRKV-SELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQL 1217
Query: 260 QICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISI 319
IC K A + + +I N +R RTT +A+ I
Sbjct: 1218 DICCKKTEALLEA---KTNELINISSSKTNAILSRISHCQHRTTKVKEAL------LIKT 1268
Query: 320 C--DNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEI---K 374
C L L + +E + +++ Q+ Q++E E+ ++ ++E L+ + E +
Sbjct: 1269 CTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQ--IKSMKADIESLVTEKEALQKE 1326
Query: 375 GEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRKCLTDTNLFQ 434
G + ++S C Q K + S+ A + +E+ K K +S K LTD N+
Sbjct: 1327 GGNQQQAASEKES-CITQLKKELSENINAVTLMKEEL--KEKKVEISSLSKQLTDLNVQL 1383
Query: 435 KNS 437
+NS
Sbjct: 1384 QNS 1386
Score = 42.0 bits (97), Expect = 0.001
Identities = 92/399 (23%), Positives = 166/399 (41%), Gaps = 95/399 (23%)
Query: 56 ILALKTLQEKIHRLELERTQAEDNLNILSREAA---QYKKALENETNERNLAHQELIK-- 110
+ L+TLQ+++ R E + ++ + + K+AL+ + +ER L E IK
Sbjct: 278 VKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDER-LQELEKIKDL 336
Query: 111 ---QKKDISIQLSSAQSRCTLLEKQLEYTKRMVL-NVEREKNMILE-------------- 152
+K + QL A++ L +QLE K MV+ +R+ + LE
Sbjct: 337 HMAEKTKLITQLRDAKN----LIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIK 392
Query: 153 ----QQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIK---HLEEKLK- 204
Q +L+ +KE+ + + +LEK L+T QKT E + K ++E++K
Sbjct: 393 QMTTQGEELREQKEKSERAAFEELEK---------ALSTAQKTEEARRKLKAEMDEQIKT 443
Query: 205 ----EEEHQRKLFQDKASELQTGLEI-SKIIMSSVSNLKHSKEKKKSSKKTKCIK----R 255
EE + L Q+ + Q +++ K ++ L+ EK+ + K+ + K R
Sbjct: 444 IEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTR 503
Query: 256 RPPWQICSKFGA-------LPFVAEKMRQHR---DPHILQKPFNVTET----RCLPKPSR 301
+Q K L EK +Q + LQK +TE+ R L + +
Sbjct: 504 EREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAE 563
Query: 302 T---------TSWCKAIPPDSEKSISICDNLSE---------LLMAMQDELDQMSMEHQ- 342
T +S K++ + +S + +L +M + + + S++HQ
Sbjct: 564 TYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQ 623
Query: 343 --------ELLKQMKETESHSVCDDIECELECLLKKMEI 373
++LKQ +TE + + E E E LLK EI
Sbjct: 624 DALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEI 662
Score = 37.4 bits (85), Expect = 0.029
Identities = 42/219 (19%), Positives = 89/219 (40%), Gaps = 58/219 (26%)
Query: 63 QEKIHRLELER-TQAEDNLNILSREAAQYK--KALENETNERNLAH-------------- 105
Q+++HR+E+E T + L L + + K + LE T E++ +H
Sbjct: 1866 QKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQH 1925
Query: 106 ------------------QELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVERE- 146
+E+++ +KD+ + Q +L+K+ + + + E+E
Sbjct: 1926 NDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQED 1985
Query: 147 ---------KNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIK 197
K ++ E QL +++++ +M + + K +E E L + Q+ +K
Sbjct: 1986 LELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAEL--LESHQEETNQLLK 2043
Query: 198 HLEEKLKEEEHQRKLFQD-----------KASELQTGLE 225
+ EK + + K +++ K +LQT LE
Sbjct: 2044 KIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLE 2082
Score = 31.6 bits (70), Expect = 1.6
Identities = 34/155 (21%), Positives = 74/155 (47%), Gaps = 8/155 (5%)
Query: 60 KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETN--ERNLAHQELIKQKKDISI 117
KTLQEK ++ + ++ + L R+ ++ +E T+ E+ A Q++ + K +
Sbjct: 1840 KTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTEL 1899
Query: 118 QLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDV 177
+ + + K +++ N+E + N + + A +REK++ ++ + L +
Sbjct: 1900 LEENTEEK----SKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRM 1955
Query: 178 LEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKL 212
L KE + K D+ + EEK+K+E+ +L
Sbjct: 1956 LRKEHQQELEILKKEYDQER--EEKIKQEQEDLEL 1988
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 59.7 bits (143), Expect = 5e-09
Identities = 62/317 (19%), Positives = 137/317 (43%), Gaps = 47/317 (14%)
Query: 102 NLAHQELIKQKKDISIQLSSAQSRCTL--LEKQLEYTKRMVLNVEREKNMILEQQAQLQR 159
N+ H +K I L SA++ + ++++ E TK + E ++ + E+ L +
Sbjct: 827 NVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQ 886
Query: 160 EKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH-------QRKL 212
EK Q+++ A+ + L E+ C +L T+ E KIK + E+ ++EE +++
Sbjct: 887 EKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK 946
Query: 213 FQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVA 272
+D+ SEL+ ++ ++ ++ V KH+ E K + + + L
Sbjct: 947 LEDECSELKKDIDDLELTLAKVEKEKHATENKVKN-------------LTEEMAGLDETI 993
Query: 273 EKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQD 332
K+ + E + L + + T D + + L++ + ++
Sbjct: 994 AKLTK--------------EKKALQEAHQQTL------DDLQAEEDKVNTLTKAKIKLEQ 1033
Query: 333 ELDQM--SMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCK 390
++D + S+E ++ ++ E + D++ E + K + KLKK + +
Sbjct: 1034 QVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSG 1093
Query: 391 LQQKVQNSKMSEASGIQ 407
LQ K+++ +A G+Q
Sbjct: 1094 LQSKIED---EQALGMQ 1107
Score = 52.0 bits (123), Expect = 1e-06
Identities = 84/392 (21%), Positives = 171/392 (43%), Gaps = 43/392 (10%)
Query: 29 EPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAA 88
E +++ N E+T+ K L + L+ + ++E E+ E+ + L+ E A
Sbjct: 928 ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 987
Query: 89 QYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKN 148
+ + T E+ A QE +Q D L + + + L K ++ V ++E
Sbjct: 988 GLDETIAKLTKEKK-ALQEAHQQTLD---DLQAEEDKVNTLTKAKIKLEQQVDDLEGS-- 1041
Query: 149 MILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH 208
LEQ+ +++ + E+ + KL L+ L +E +T DK + L+EKLK++E
Sbjct: 1042 --LEQEKKIRMDLERAKRKLEGDLK----LAQE-----STMDIENDK-QQLDEKLKKKEF 1089
Query: 209 QRKLFQDKASELQT-GLEISKIIMSSVSNLKHSKEKKKSSK--KTKCIKRRPPW------ 259
+ Q K + Q G+++ K I + ++ +E+ ++ + + K K+R
Sbjct: 1090 EMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1149
Query: 260 --QICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSI 317
+ + G +M + R+ + ++ E + + T K +E
Sbjct: 1150 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGE 1209
Query: 318 SICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQ 377
I DNL + ++ E +M ME +L M ET S + + LE + + +E +Q
Sbjct: 1210 QI-DNLQRVKQKLEKEKSEMKMEIDDLASNM-ETVSKA-----KGNLEKMCRALE---DQ 1259
Query: 378 ISKLKKHQDSVCKLQQKVQNSKMSEASGIQQE 409
+S++K ++ QQ++ N ++ + +Q E
Sbjct: 1260 LSEIKTKEEE----QQRLINDLTAQRARLQTE 1287
Score = 46.6 bits (109), Expect = 5e-05
Identities = 45/198 (22%), Positives = 89/198 (44%), Gaps = 6/198 (3%)
Query: 53 QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQK 112
QA +L +E+ +L + Q E + ++ A ++ T ++ E + K
Sbjct: 896 QAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 955
Query: 113 KDIS-IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAK 171
KDI ++L+ A+ +EK+ T+ V N+ E + E A+L +EK+ Q
Sbjct: 956 KDIDDLELTLAK-----VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT 1010
Query: 172 LEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIM 231
L+ L E + LT + E ++ LE L++E+ R + +L+ L++++
Sbjct: 1011 LDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQEST 1070
Query: 232 SSVSNLKHSKEKKKSSKK 249
+ N K ++K K+
Sbjct: 1071 MDIENDKQQLDEKLKKKE 1088
Score = 43.1 bits (100), Expect = 5e-04
Identities = 65/326 (19%), Positives = 139/326 (42%), Gaps = 32/326 (9%)
Query: 68 RLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCT 127
++E + + E LN +R AA+ AL N N + + KD + L A
Sbjct: 1621 KMEGDLNEMEIQLNHANRMAAE---ALRNYRNTQAIL--------KDTQLHLDDALRSQE 1669
Query: 128 LLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTT 187
L++QL +R ++ E + Q +R ++ + +L E++ +L + L
Sbjct: 1670 DLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLIN 1729
Query: 188 TQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQT-GLEISKIIMSSVSNLKHSKEKKKS 246
T+K E I ++ ++++ + + ++KA + T +++ + H + KK+
Sbjct: 1730 TKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1789
Query: 247 SKKT-KCIKRR--PPWQICSKFG--ALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSR 301
++T K ++ R Q+ K G + + ++R+ ++ NV + L K R
Sbjct: 1790 LEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHER 1849
Query: 302 TTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCD--- 358
+ K+I + +QD +D++ + + +Q +E E S +
Sbjct: 1850 KVKELTYQTEEDRKNI----------LRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSK 1899
Query: 359 --DIECELECLLKKMEIKGEQISKLK 382
I+ ELE ++ +I Q++KL+
Sbjct: 1900 FRRIQHELEEAEERADIAESQVNKLR 1925
Score = 42.4 bits (98), Expect = 9e-04
Identities = 63/361 (17%), Positives = 147/361 (40%), Gaps = 34/361 (9%)
Query: 62 LQEKIHRLELERTQAEDNLNILSREAAQYKK---ALENETNERNLAHQELIKQKKDISIQ 118
L+++ +++E N+ +S+ +K ALE++ +E +E + D++ Q
Sbjct: 1221 LEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQ 1280
Query: 119 LSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVL 178
+ Q+ +QL+ +V + R K +Q +L+R+ E++ A L
Sbjct: 1281 RARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSS 1340
Query: 179 EKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLK 238
+C L E+ +EE+ + Q S+ + E+++ ++
Sbjct: 1341 RHDC--------------DLLREQYEEEQEAKAELQRAMSKANS--EVAQWRTKYETDAI 1384
Query: 239 HSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNV--TETRCL 296
E+ + +KK + + + A EK +Q + +V T C
Sbjct: 1385 QRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACA 1444
Query: 297 PKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSME-------HQELLKQMK 349
+ ++ K + +K C+ L A Q E +S E ++E L Q++
Sbjct: 1445 ALDKKQRNFDKILAEWKQK----CEETHAELEASQKESRSLSTELFKIKNAYEESLDQLE 1500
Query: 350 ETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQE 409
+ + +++ E+ L +++ G++I +L+K + V + + ++Q + + ++ E
Sbjct: 1501 TLKREN--KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHE 1558
Query: 410 D 410
+
Sbjct: 1559 E 1559
Score = 40.8 bits (94), Expect = 0.003
Identities = 80/408 (19%), Positives = 164/408 (40%), Gaps = 49/408 (12%)
Query: 59 LKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALEN---------ETNERNLAHQELI 109
++ L+E+I R +AE + LSRE + + LE E N++ A E
Sbjct: 1119 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA--EFQ 1176
Query: 110 KQKKDIS-IQLSSAQSRCTLLEKQLEYTKRM---VLNVEREKNMILEQQAQLQREKEQDQ 165
K ++D+ L + TL +K + + + N++R K +L++EK + +
Sbjct: 1177 KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQ-------KLEKEKSEMK 1229
Query: 166 MKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH-------QRKLFQDKAS 218
M++ ++ + K L + ED++ ++ K +E++ QR Q ++
Sbjct: 1230 MEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESG 1289
Query: 219 ELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQH 278
E L+ ++S + S+ K+ +++ + +KR+ +I +K AL + R
Sbjct: 1290 EYSRQLDEKDTLVSQL-----SRGKQAFTQQIEELKRQLEEEIKAK-SALAHALQSSRHD 1343
Query: 279 ----RDPHILQKPFNVTETRCLPKP-SRTTSWCKAIPPDSEKSISICDNLSELLMAMQDE 333
R+ + ++ R + K S W D +I + L E +
Sbjct: 1344 CDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETD---AIQRTEELEEAKKKLAQR 1400
Query: 334 LDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKL-- 391
L Q + EH E + K ++ E+E L+ +E + L K Q + K+
Sbjct: 1401 L-QDAEEHVEAV-NAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILA 1458
Query: 392 --QQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRKCLTDTNLFQKNS 437
+QK + + + ++ S IKN+ + L ++ +
Sbjct: 1459 EWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKREN 1506
Score = 38.9 bits (89), Expect = 0.010
Identities = 83/454 (18%), Positives = 180/454 (39%), Gaps = 65/454 (14%)
Query: 60 KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETN---ERNLAHQELIKQKKDIS 116
++L ++ +++ ++ D L L RE ++ + + T E EL K KK +
Sbjct: 1479 RSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVE 1538
Query: 117 IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQ--QAQLQREKEQDQM-------- 166
+ S Q+ E LE+ + +L ++ E N + + + ++++E DQM
Sbjct: 1539 QEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIV 1598
Query: 167 ----------------------KLYAKLEKLDVLEKECFRLT--------TTQKTAEDKI 196
K+ L ++++ R+ TQ +D
Sbjct: 1599 ESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQ 1658
Query: 197 KHLEEKLKEEE---HQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKK--KSSKKTK 251
HL++ L+ +E Q + + +A+ LQ +E + + + E++ +S++ +
Sbjct: 1659 LHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQ 1718
Query: 252 CIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTE--TRCLPKPSRTTSWCKAI 309
+ + I +K +++ + D I+Q+ N E + + + K
Sbjct: 1719 LLHTQNTSLINTKKKLETDISQIQGEMED--IIQEARNAEEKAKKAITDAAMMAEELKKE 1776
Query: 310 PPDSEKSISICDNLSELLMAMQ---DELDQMSMEHQELLKQMKETESHSVCDDIECELEC 366
S + NL + + +Q DE +Q++++ + KQ+++ E+ ++E E+E
Sbjct: 1777 QDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGK--KQIQKLEAR--VRELEGEVES 1832
Query: 367 LLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRKC 426
K+ E + L+KH+ V +L + + + + D K+ K +
Sbjct: 1833 EQKR---NVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEA 1889
Query: 427 LTDTNLFQKNSSFHPIRVHNLQMKLRRDDIMWEQ 460
+N+ S F I+ H L+ R DI Q
Sbjct: 1890 EEQSNV--NLSKFRRIQ-HELEEAEERADIAESQ 1920
>gi|41327691 kinesin-like motor protein C20orf23 [Homo sapiens]
Length = 1317
Score = 59.7 bits (143), Expect = 5e-09
Identities = 88/397 (22%), Positives = 173/397 (43%), Gaps = 53/397 (13%)
Query: 63 QEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAH----------------Q 106
++K + ELER Q E E Q + + E+ +R H +
Sbjct: 622 KQKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKRRSFHIENKLKDLLAEKEKFEE 681
Query: 107 ELIKQKKDISIQLSSAQSRCTL-LEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQ 165
E ++++++I +Q + L ++++L+ K + N + EK I ++ QLQ+EK++
Sbjct: 682 ERLREQQEIELQKKRQEEETFLRVQEELQRLKELNNNEKAEKFQIFQELDQLQKEKDEQ- 740
Query: 166 MKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQ----DKASELQ 221
YAKLE LEK+ RL +K + HLEE+L+E++ +L + E +
Sbjct: 741 ---YAKLE----LEKK--RLEEQEKEQVMLVAHLEEQLREKQEMIQLLRRGEVQWVEEEK 791
Query: 222 TGLE-----ISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGAL----PFVA 272
LE + ++ + + +E +K+ + KRR ++ + L +
Sbjct: 792 RDLEGIRESLLRVKEARAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLEKDLVQQKDILK 851
Query: 273 EKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQD 332
+++++ ++ K + E+R L K + + +P D EK + L +
Sbjct: 852 KEVQEEQEILECLKCEHDKESRLLEKHDESVTDVTEVPQDFEK----IKPVEYRLQYKER 907
Query: 333 ELDQMSMEHQELLKQMKETESHSVCDDIECELECLL----KKMEIKGEQISKLKKHQDSV 388
+L + H L + K+ + + D L+ L K+ME K EQ+++ + + + +
Sbjct: 908 QLQYLLQNHLPTLLEEKQ-RAFEILDRGPLSLDNTLYQVEKEMEEKEEQLAQYQANANQL 966
Query: 389 CKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRK 425
KLQ + + A+ +QE+ K K I S K
Sbjct: 967 QKLQATFEFT----ANIARQEEKVRKKEKEILESREK 999
Score = 40.0 bits (92), Expect = 0.004
Identities = 39/157 (24%), Positives = 73/157 (46%), Gaps = 13/157 (8%)
Query: 61 TLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS 120
+L ++++E E + E+ L A Q +K N+A QE +KK+ I S
Sbjct: 937 SLDNTLYQVEKEMEEKEEQLAQYQANANQLQKLQATFEFTANIARQEEKVRKKEKEILES 996
Query: 121 SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQR-----EKEQDQMKLYAKLE-K 174
+ + LE+ L +R ++R + +E + Q Q+ ++Q L A LE +
Sbjct: 997 REKQQREALERALARLERRHSALQRHSTLGMEIEEQRQKLASLNSGSREQSGLQASLEAE 1056
Query: 175 LDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRK 211
+ LEK+ Q+ E +I+ L++K+ E + +K
Sbjct: 1057 QEALEKD-------QERLEYEIQQLKQKIYEVDGVQK 1086
Score = 32.3 bits (72), Expect = 0.93
Identities = 35/153 (22%), Positives = 73/153 (47%), Gaps = 22/153 (14%)
Query: 85 REAAQYK-KALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNV 143
+EAA+ + K + +L+ +L K ++++S + L LE+ ++
Sbjct: 555 KEAAKLREKRKSGLLSSFSLSMTDLSKSRENLSAVM--------LYNPGLEFERQ----- 601
Query: 144 EREKNMILEQQAQLQREKEQDQMKLYAKLEKL----DVLEKECFRLTTTQKTAEDKIK-- 197
+RE+ LE + +L E E+ Q A+LE++ + KE + + E+ +K
Sbjct: 602 QREELEKLESKRKLIEEMEEKQKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKRR 661
Query: 198 --HLEEKLKEEEHQRKLFQDKASELQTGLEISK 228
H+E KLK+ +++ F+++ Q +E+ K
Sbjct: 662 SFHIENKLKDLLAEKEKFEEERLREQQEIELQK 694
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 59.3 bits (142), Expect = 7e-09
Identities = 85/412 (20%), Positives = 175/412 (42%), Gaps = 59/412 (14%)
Query: 26 TQNEPSQNCHPANLEVTSPKILHSPNS----QALILALKTLQEKIHRLELERTQAEDNLN 81
T +E SQ +E+ + + S Q+L A KT+Q+K
Sbjct: 1436 TGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDK---------------- 1479
Query: 82 ILSREAAQYKKALENETNERNLAHQE---LIKQKKDISIQLSSAQSRCTLLEKQLEYTKR 138
++E + K+ ++ ETN+R E L + + D+ SSA L+ Q + R
Sbjct: 1480 --NKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTR 1537
Query: 139 MVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDV----LEKECFRLTTTQKTAED 194
+ ++ ER +Q + K+QD + L++L + +E+E RL T
Sbjct: 1538 LRIDYERV--------SQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSC 1589
Query: 195 KIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMS-SVSNLKHSKEKKKSSKKTKCI 253
K K LEE+L+ K K + L LE + I+ S +L+ ++ + K
Sbjct: 1590 KRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQR 1649
Query: 254 KRRPPWQICSKFGALPF-VAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPD 312
+ ++ S+ AL + ++ + H+ + F + + SR+ + K +
Sbjct: 1650 TQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQ----KAIEDKSRSLNESKI---E 1702
Query: 313 SEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESH------------SVCDDI 360
E+ S+ +NL++ + +++EL + +E+ +L + E +S + ++
Sbjct: 1703 IERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNR 1762
Query: 361 ECELECLLKKMEIKGEQI-SKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDS 411
EL+ L+ ++ + E + +++K Q + ++Q SK +Q+ +S
Sbjct: 1763 TLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERES 1814
Score = 39.7 bits (91), Expect = 0.006
Identities = 88/428 (20%), Positives = 182/428 (42%), Gaps = 50/428 (11%)
Query: 64 EKIHRLELERTQAEDNLNILSREAAQ-YKKALENETNERNLAH--QELIKQKKDISIQLS 120
E + + ++RT + ++ +EAA + + +E T + E++K +D+ ++
Sbjct: 973 ETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLK-- 1030
Query: 121 SAQSRCTLLEKQLEYTKRMVLNVER-EKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLE 179
++ +LE++L + N E KN L+Q Q + + E Q K AKL L+ L+
Sbjct: 1031 --NTKIEVLEEELRLARDA--NSENCNKNKFLDQNLQ-KYQAECSQFK--AKLASLEELK 1083
Query: 180 KECFRLTTTQKTAEDK----IKHLEEKL-------KEEEHQRKLFQDKASELQTGL-EIS 227
++ + K DK IK L EK+ ++E+ +RK +D+ + + ++
Sbjct: 1084 RQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQ 1143
Query: 228 KIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAE----KMRQHRDPHI 283
K NL K + + + K K + + + G E K+R H + +
Sbjct: 1144 KARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEM 1203
Query: 284 --LQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEH 341
L+ + TE + S K DS+ + D LS ++DE+ +++
Sbjct: 1204 SNLRNKYE-TEINITKTTIKEISMQK--EDDSKNLRNQLDRLSRENRDLKDEIVRLNDSI 1260
Query: 342 QELLKQMKETESHSVCDDIECELECLLKK--MEIKGEQISKLK-----KHQDSVCKLQQK 394
+ +Q + E +++ C E + KK +EI+ +Q+ + + +H+ S+ + +
Sbjct: 1261 LQATEQRRRAEENAL-QQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKT 1319
Query: 395 VQ--NSKMSEASGIQQEDSYPKG------SKNIKNSPRKCLTDTNLFQKNSSFHPIRVHN 446
+Q N ++ QE++ + SK N + ++ N F+ + +H
Sbjct: 1320 IQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQ 1379
Query: 447 LQMKLRRD 454
L M+ D
Sbjct: 1380 LTMQKEED 1387
Score = 36.6 bits (83), Expect = 0.049
Identities = 39/204 (19%), Positives = 92/204 (45%), Gaps = 18/204 (8%)
Query: 60 KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQL 119
K +++K L + + E L L+ + LE E L + +L + + +
Sbjct: 1687 KAIEDKSRSLNESKIEIE-RLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSE----- 1740
Query: 120 SSAQSRCTLLE--KQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDV 177
+ + T+LE QL+ + L ++ N + ++ L++E E+ Q + ++
Sbjct: 1741 ADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQE 1800
Query: 178 LEKECFRLTTTQKTAEDKIKHLE------EKLKEEEHQRKLFQDKASELQTGLEISKIIM 231
+ +C ++ +++ KIK LE ++L++E ++ K + + ++ LE K +
Sbjct: 1801 SKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQI 1860
Query: 232 SSVSNLKHSKEKKKSSKKTKCIKR 255
+ N + K + S+K + I++
Sbjct: 1861 QNDLN----QWKTQYSRKEEAIRK 1880
Score = 34.7 bits (78), Expect = 0.19
Identities = 42/176 (23%), Positives = 69/176 (39%), Gaps = 18/176 (10%)
Query: 62 LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQEL------IKQKKDI 115
LQ I+ L+ ER + ++A + ++ N+ QE IK +
Sbjct: 1766 LQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQD 1825
Query: 116 SIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMI---LEQQAQLQREKEQDQMKLYAKL 172
+L + + LE R+ +E EK I L Q KE+ K+ ++
Sbjct: 1826 KARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESER 1885
Query: 173 EKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISK 228
EK + EK R + AE IK +EE+ R+ +D E Q+ LE +
Sbjct: 1886 EKSE-REKNSLRSEIERLQAE--IKRIEERC------RRKLEDSTRETQSQLETER 1932
Score = 33.9 bits (76), Expect = 0.32
Identities = 36/150 (24%), Positives = 71/150 (47%), Gaps = 17/150 (11%)
Query: 53 QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQK 112
++L++ +K L++ RL+ + ED LN + K LE ET + Q L +K
Sbjct: 1813 ESLLVKIKVLEQDKARLQ----RLEDELN-------RAKSTLEAETRVK----QRLECEK 1857
Query: 113 KDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKL 172
+ I L+ +++ + E+ + + EREKN + + +LQ E ++ + + KL
Sbjct: 1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1917
Query: 173 EKLDVLEKECFRLTTTQKTAEDKIKHLEEK 202
E D + +L T + + +I L ++
Sbjct: 1918 E--DSTRETQSQLETERSRYQREIDKLRQR 1945
Score = 33.5 bits (75), Expect = 0.42
Identities = 42/194 (21%), Positives = 86/194 (44%), Gaps = 20/194 (10%)
Query: 68 RLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCT 127
RLE E+ Q +++LN + ++ ++A+ +ER + +E K + ++ Q+
Sbjct: 1852 RLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSERE----KNSLRSEIERLQAEIK 1907
Query: 128 LLEKQLEYTKRMVLNVEREKNMILE-QQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLT 186
+E E +R + + RE LE ++++ QRE ++ + + Y + + EC
Sbjct: 1908 RIE---ERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRE---TQTECEWTV 1961
Query: 187 TTQKTAEDKIKH-------LEEKLKEEEHQRKLFQDKASELQTGLEISKII--MSSVSNL 237
T K D ++ E +L ++ KL + K S + EI + S++
Sbjct: 1962 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 2021
Query: 238 KHSKEKKKSSKKTK 251
S ++K S + K
Sbjct: 2022 SASPKEKYSLVEAK 2035
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 58.9 bits (141), Expect = 9e-09
Identities = 97/428 (22%), Positives = 187/428 (43%), Gaps = 73/428 (17%)
Query: 53 QALILALKTLQEKIHRLELERTQAEDNLN---ILSREAAQYKKALENETNERNLAHQ--- 106
Q L+ +++ Q+++++ E + Q +D L L + Q+ + +T+ LA +
Sbjct: 548 QRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHK 607
Query: 107 ---ELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRM--VLNVEREKNMIL-EQQAQLQRE 160
E KQ K L+S + R T E++L+ + M +L E +K L +QA E
Sbjct: 608 VIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHE 667
Query: 161 KEQDQMKLYAKLEKLDVLEK----------ECFRLTTTQ-KTAEDKIKHLEEKLKEE--- 206
E+ Q +Y K +K+ +LE+ E F++ Q K + +++ L+ + E+
Sbjct: 668 LEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNK 727
Query: 207 ---EHQRKLFQDKASELQTGLEISKIIMSSVSNLKHS-----KEKKKSSKKTKCIKRRPP 258
E K Q+K +L+T E+ + + V+ + E +K+ + +K +
Sbjct: 728 DVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQN 787
Query: 259 WQICSKFGALPFVAEKMRQHRDPHI----------LQKPFNVTETRCLPKPSRT------ 302
Q+ F +L +K+ +D I L K N +T L S+
Sbjct: 788 DQV--SFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNL 845
Query: 303 -------TSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLK-QMKETESH 354
+ KA+ + EK ++ N + L +Q+E + + QE+ + +KE S
Sbjct: 846 LKGKEEQMNTMKAVLEEKEKDLA---NTGKWLQDLQEENESLKAHVQEVAQHNLKEASSA 902
Query: 355 SVCDDIECELECLLKKMEIKGEQISKLKKHQD----SVCKLQQKVQNSKMSEASGIQQ-- 408
S + ELE +LK+ E + +++ + K ++ S +L Q VQ+ S I+Q
Sbjct: 903 SQFE----ELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLK 958
Query: 409 EDSYPKGS 416
+ +Y + S
Sbjct: 959 QQNYQQAS 966
Score = 44.3 bits (103), Expect = 2e-04
Identities = 47/196 (23%), Positives = 91/196 (46%), Gaps = 26/196 (13%)
Query: 53 QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELI--- 109
+AL K LQ+K+++ ER Q + + + ++E KK + NL++ E +
Sbjct: 1018 EALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVL--KKLFPKVSVPSNLSYGEWLHGF 1075
Query: 110 KQKKDISIQLSSAQSRCTLLEKQLEYTKRM----VLNVEREKNMILEQQA---QLQREKE 162
++K + +S +LE +L+ M L E+ K+++ E + +LQR E
Sbjct: 1076 EKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVE 1135
Query: 163 QDQMKLYAKLEK-----------LDVLEKECFRLTTTQKTAED---KIKHLEEKLKEEEH 208
Q++ K K+++ E+E RL + K E+ + +HLE +L++ E
Sbjct: 1136 QEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEM 1195
Query: 209 QRKLFQDKASELQTGL 224
+R + + EL+ L
Sbjct: 1196 ERSTYVTEVRELKAQL 1211
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 58.9 bits (141), Expect = 9e-09
Identities = 63/317 (19%), Positives = 137/317 (43%), Gaps = 47/317 (14%)
Query: 102 NLAHQELIKQKKDISIQLSSAQSRCTL--LEKQLEYTKRMVLNVEREKNMILEQQAQLQR 159
N+ H +K I L SA++ + ++++ + K + E ++ + E+ L +
Sbjct: 829 NVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLK 888
Query: 160 EKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH-------QRKL 212
EK Q+++ A+ E L E+ C +L T+ E KIK + E+ ++EE +++
Sbjct: 889 EKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK 948
Query: 213 FQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVA 272
+D+ SEL+ ++ ++ ++ V KH+ E K + + + L
Sbjct: 949 LEDECSELKKDIDDLELTLAKVEKEKHATENKVKN-------------LTEEMAGLDETI 995
Query: 273 EKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQD 332
K+ + E + L + + T D + + L++ + ++
Sbjct: 996 AKLTK--------------EKKALQEAHQQTL------DDLQAEEDKVNTLTKAKIKLEQ 1035
Query: 333 ELDQM--SMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCK 390
++D + S+E ++ L+ E + D++ E ++ K + KLKK + +
Sbjct: 1036 QVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISN 1095
Query: 391 LQQKVQNSKMSEASGIQ 407
LQ K+++ +A GIQ
Sbjct: 1096 LQSKIED---EQALGIQ 1109
Score = 50.4 bits (119), Expect = 3e-06
Identities = 83/392 (21%), Positives = 169/392 (43%), Gaps = 43/392 (10%)
Query: 29 EPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAA 88
E +++ N E+T+ K L + L+ + ++E E+ E+ + L+ E A
Sbjct: 930 ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 989
Query: 89 QYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKN 148
+ + T E+ A QE +Q D L + + + L K ++ V ++E
Sbjct: 990 GLDETIAKLTKEKK-ALQEAHQQTLD---DLQAEEDKVNTLTKAKIKLEQQVDDLEGS-- 1043
Query: 149 MILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH 208
LEQ+ +L+ + E+ + KL L+ L +E E++ + L+EKLK++E
Sbjct: 1044 --LEQEKKLRMDLERAKRKLEGDLK----LAQESIM------DIENEKQQLDEKLKKKEF 1091
Query: 209 QRKLFQDKASELQT-GLEISKIIMSSVSNLKHSKEKKKSSK--KTKCIKRRPPW------ 259
+ Q K + Q G+++ K I + ++ +E+ ++ + + K K+R
Sbjct: 1092 EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1151
Query: 260 --QICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSI 317
+ + G +M + R+ + ++ E + + T K +E
Sbjct: 1152 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGE 1211
Query: 318 SICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQ 377
I DNL + ++ E +M ME +L + ET S + + LE + + +E +Q
Sbjct: 1212 QI-DNLQRVKQKLEKEKSEMKMEIDDLASNV-ETVSKA-----KGNLEKMCRTLE---DQ 1261
Query: 378 ISKLKKHQDSVCKLQQKVQNSKMSEASGIQQE 409
+S+LK ++ QQ++ N ++ +Q E
Sbjct: 1262 LSELKSKEEE----QQRLINDLTAQRGRLQTE 1289
Score = 48.1 bits (113), Expect = 2e-05
Identities = 45/198 (22%), Positives = 89/198 (44%), Gaps = 6/198 (3%)
Query: 53 QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQK 112
QA L +E+ +L + Q E + ++ A ++ T ++ E + K
Sbjct: 898 QAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 957
Query: 113 KDIS-IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAK 171
KDI ++L+ A+ +EK+ T+ V N+ E + E A+L +EK+ Q
Sbjct: 958 KDIDDLELTLAK-----VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT 1012
Query: 172 LEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIM 231
L+ L E + LT + E ++ LE L++E+ R + +L+ L++++ +
Sbjct: 1013 LDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESI 1072
Query: 232 SSVSNLKHSKEKKKSSKK 249
+ N K ++K K+
Sbjct: 1073 MDIENEKQQLDEKLKKKE 1090
Score = 45.4 bits (106), Expect = 1e-04
Identities = 80/424 (18%), Positives = 171/424 (40%), Gaps = 78/424 (18%)
Query: 59 LKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALEN---------ETNERNLAHQELI 109
++ L+E+I R +AE + LSRE + + LE E N++ A E
Sbjct: 1121 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA--EFQ 1178
Query: 110 KQKKDIS-IQLSSAQSRCTLLEKQLEYTKRM---VLNVEREKNMILEQQAQLQREKEQDQ 165
K ++D+ L + TL +K + + + N++R K +L++EK + +
Sbjct: 1179 KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQ-------KLEKEKSEMK 1231
Query: 166 MKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH-------QRKLFQDKAS 218
M++ ++ + K L +T ED++ L+ K +E++ QR Q ++
Sbjct: 1232 MEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESG 1291
Query: 219 ELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQH 278
E L+ + ++S + S+ K+ +++ + +KR+ +I +K AL + R
Sbjct: 1292 EFSRQLDEKEALVSQL-----SRGKQAFTQQIEELKRQLEEEIKAK-NALAHALQSSRHD 1345
Query: 279 ----RDPHILQKPFNVTETRCLPKP-SRTTSWCKAIPPDS-------------------- 313
R+ + ++ R L K + W D+
Sbjct: 1346 CDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQA 1405
Query: 314 -----EKSISICDNLSELLMAMQDELDQMSMEHQE-------LLKQMKE-----TESHSV 356
E + C +L + +Q+E++ + ++ + L K+ + E
Sbjct: 1406 AEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQK 1465
Query: 357 CDDIECELECLLKKMEIKGEQISKLKK-HQDSVCKLQQKVQNSKMSEASGIQQEDSYPKG 415
C++ ELE K+ G ++ K+K +++S+ +L+ + +K + + +G
Sbjct: 1466 CEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEG 1525
Query: 416 SKNI 419
K I
Sbjct: 1526 GKRI 1529
Score = 43.9 bits (102), Expect = 3e-04
Identities = 63/326 (19%), Positives = 136/326 (41%), Gaps = 32/326 (9%)
Query: 68 RLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCT 127
++E + + E LN +R AA+ AL N N + + KD I L A
Sbjct: 1623 KMEGDLNEMEIQLNHANRMAAE---ALRNYRNTQGIL--------KDTQIHLDDALRSQE 1671
Query: 128 LLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTT 187
L++QL +R ++ E + Q +R ++ + +L E++ +L + L
Sbjct: 1672 DLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLIN 1731
Query: 188 TQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTG----LEISKIIMSSVSNLKHSKEK 243
T+K E I ++ ++++ + + ++KA + T E K + ++L+ K+
Sbjct: 1732 TKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1791
Query: 244 KKSSKKTKCIKRRPPWQICSKFG--ALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSR 301
+ + K ++ Q+ K G + + ++R+ ++ N + L K R
Sbjct: 1792 MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHER 1851
Query: 302 TTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCD--- 358
+ K+I + +QD +D++ + + +Q +E E S +
Sbjct: 1852 RVKELTYQTEEDRKNI----------LRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAK 1901
Query: 359 --DIECELECLLKKMEIKGEQISKLK 382
++ ELE ++ +I Q++KL+
Sbjct: 1902 FRKLQHELEEAEERADIAESQVNKLR 1927
Score = 35.4 bits (80), Expect = 0.11
Identities = 62/360 (17%), Positives = 150/360 (41%), Gaps = 41/360 (11%)
Query: 60 KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETN---ERNLAHQELIKQKKDIS 116
++L ++ +++ ++ D L L RE ++ + + T E EL K KK +
Sbjct: 1481 RSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVE 1540
Query: 117 IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLD 176
+ Q+ E LE+ + +L ++ E N + K + K+ K E++D
Sbjct: 1541 QEKCELQAALEEAEASLEHEEGKILRIQLELNQV----------KSEVDRKIAEKDEEID 1590
Query: 177 VLEKECFRLT-TTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVS 235
L++ R+ + Q T + +I+ + ++ +K + +E++ L +
Sbjct: 1591 QLKRNHIRIVESMQSTLDAEIRSRNDAIR----LKKKMEGDLNEMEIQLNHAN------- 1639
Query: 236 NLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQ-HRDPHILQKPFNVTETR 294
+ + E ++ + T+ I + + + + E++ R ++LQ + E R
Sbjct: 1640 --RMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQA--EIEELR 1695
Query: 295 C-LPKPSRTTSWCKAIPPDSEKSISICDNLSELLM----AMQDELDQMSMEHQELLKQMK 349
L + R+ + D+ + + + + L+ ++ ++ QM E +++L++ +
Sbjct: 1696 ATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEAR 1755
Query: 350 ETE---SHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCK-LQQKVQNSKMSEASG 405
E ++ D E LKK + + ++KK+ + K LQ ++ ++ G
Sbjct: 1756 NAEEKAKKAITDAAMMAEE--LKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKG 1813
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 58.9 bits (141), Expect = 9e-09
Identities = 63/317 (19%), Positives = 137/317 (43%), Gaps = 47/317 (14%)
Query: 102 NLAHQELIKQKKDISIQLSSAQSRCTL--LEKQLEYTKRMVLNVEREKNMILEQQAQLQR 159
N+ H +K I L SA++ + ++++ + K + E ++ + E+ L +
Sbjct: 829 NVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLK 888
Query: 160 EKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH-------QRKL 212
EK Q+++ A+ E L E+ C +L T+ E KIK + E+ ++EE +++
Sbjct: 889 EKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK 948
Query: 213 FQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVA 272
+D+ SEL+ ++ ++ ++ V KH+ E K + + + L
Sbjct: 949 LEDECSELKKDIDDLELTLAKVEKEKHATENKVKN-------------LTEEMAGLDETI 995
Query: 273 EKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQD 332
K+ + E + L + + T D + + L++ + ++
Sbjct: 996 AKLTK--------------EKKALQEAHQQTL------DDLQAEEDKVNTLTKAKIKLEQ 1035
Query: 333 ELDQM--SMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCK 390
++D + S+E ++ L+ E + D++ E ++ K + KLKK + +
Sbjct: 1036 QVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISN 1095
Query: 391 LQQKVQNSKMSEASGIQ 407
LQ K+++ +A GIQ
Sbjct: 1096 LQSKIED---EQALGIQ 1109
Score = 50.4 bits (119), Expect = 3e-06
Identities = 83/392 (21%), Positives = 169/392 (43%), Gaps = 43/392 (10%)
Query: 29 EPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAA 88
E +++ N E+T+ K L + L+ + ++E E+ E+ + L+ E A
Sbjct: 930 ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA 989
Query: 89 QYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKN 148
+ + T E+ A QE +Q D L + + + L K ++ V ++E
Sbjct: 990 GLDETIAKLTKEKK-ALQEAHQQTLD---DLQAEEDKVNTLTKAKIKLEQQVDDLEGS-- 1043
Query: 149 MILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH 208
LEQ+ +L+ + E+ + KL L+ L +E E++ + L+EKLK++E
Sbjct: 1044 --LEQEKKLRMDLERAKRKLEGDLK----LAQESIM------DIENEKQQLDEKLKKKEF 1091
Query: 209 QRKLFQDKASELQT-GLEISKIIMSSVSNLKHSKEKKKSSK--KTKCIKRRPPW------ 259
+ Q K + Q G+++ K I + ++ +E+ ++ + + K K+R
Sbjct: 1092 EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1151
Query: 260 --QICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSI 317
+ + G +M + R+ + ++ E + + T K +E
Sbjct: 1152 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGE 1211
Query: 318 SICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQ 377
I DNL + ++ E +M ME +L + ET S + + LE + + +E +Q
Sbjct: 1212 QI-DNLQRVKQKLEKEKSEMKMEIDDLASNV-ETVSKA-----KGNLEKMCRTLE---DQ 1261
Query: 378 ISKLKKHQDSVCKLQQKVQNSKMSEASGIQQE 409
+S+LK ++ QQ++ N ++ +Q E
Sbjct: 1262 LSELKSKEEE----QQRLINDLTAQRGRLQTE 1289
Score = 48.1 bits (113), Expect = 2e-05
Identities = 45/198 (22%), Positives = 89/198 (44%), Gaps = 6/198 (3%)
Query: 53 QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQK 112
QA L +E+ +L + Q E + ++ A ++ T ++ E + K
Sbjct: 898 QAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 957
Query: 113 KDIS-IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAK 171
KDI ++L+ A+ +EK+ T+ V N+ E + E A+L +EK+ Q
Sbjct: 958 KDIDDLELTLAK-----VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT 1012
Query: 172 LEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIM 231
L+ L E + LT + E ++ LE L++E+ R + +L+ L++++ +
Sbjct: 1013 LDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESI 1072
Query: 232 SSVSNLKHSKEKKKSSKK 249
+ N K ++K K+
Sbjct: 1073 MDIENEKQQLDEKLKKKE 1090
Score = 45.4 bits (106), Expect = 1e-04
Identities = 80/424 (18%), Positives = 171/424 (40%), Gaps = 78/424 (18%)
Query: 59 LKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALEN---------ETNERNLAHQELI 109
++ L+E+I R +AE + LSRE + + LE E N++ A E
Sbjct: 1121 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA--EFQ 1178
Query: 110 KQKKDIS-IQLSSAQSRCTLLEKQLEYTKRM---VLNVEREKNMILEQQAQLQREKEQDQ 165
K ++D+ L + TL +K + + + N++R K +L++EK + +
Sbjct: 1179 KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQ-------KLEKEKSEMK 1231
Query: 166 MKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH-------QRKLFQDKAS 218
M++ ++ + K L +T ED++ L+ K +E++ QR Q ++
Sbjct: 1232 MEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESG 1291
Query: 219 ELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQH 278
E L+ + ++S + S+ K+ +++ + +KR+ +I +K AL + R
Sbjct: 1292 EFSRQLDEKEALVSQL-----SRGKQAFTQQIEELKRQLEEEIKAK-NALAHALQSSRHD 1345
Query: 279 ----RDPHILQKPFNVTETRCLPKP-SRTTSWCKAIPPDS-------------------- 313
R+ + ++ R L K + W D+
Sbjct: 1346 CDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQA 1405
Query: 314 -----EKSISICDNLSELLMAMQDELDQMSMEHQE-------LLKQMKE-----TESHSV 356
E + C +L + +Q+E++ + ++ + L K+ + E
Sbjct: 1406 AEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQK 1465
Query: 357 CDDIECELECLLKKMEIKGEQISKLKK-HQDSVCKLQQKVQNSKMSEASGIQQEDSYPKG 415
C++ ELE K+ G ++ K+K +++S+ +L+ + +K + + +G
Sbjct: 1466 CEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEG 1525
Query: 416 SKNI 419
K I
Sbjct: 1526 GKRI 1529
Score = 43.9 bits (102), Expect = 3e-04
Identities = 63/326 (19%), Positives = 136/326 (41%), Gaps = 32/326 (9%)
Query: 68 RLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCT 127
++E + + E LN +R AA+ AL N N + + KD I L A
Sbjct: 1623 KMEGDLNEMEIQLNHANRMAAE---ALRNYRNTQGIL--------KDTQIHLDDALRSQE 1671
Query: 128 LLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTT 187
L++QL +R ++ E + Q +R ++ + +L E++ +L + L
Sbjct: 1672 DLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLIN 1731
Query: 188 TQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTG----LEISKIIMSSVSNLKHSKEK 243
T+K E I ++ ++++ + + ++KA + T E K + ++L+ K+
Sbjct: 1732 TKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1791
Query: 244 KKSSKKTKCIKRRPPWQICSKFG--ALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSR 301
+ + K ++ Q+ K G + + ++R+ ++ N + L K R
Sbjct: 1792 MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHER 1851
Query: 302 TTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCD--- 358
+ K+I + +QD +D++ + + +Q +E E S +
Sbjct: 1852 RVKELTYQTEEDRKNI----------LRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAK 1901
Query: 359 --DIECELECLLKKMEIKGEQISKLK 382
++ ELE ++ +I Q++KL+
Sbjct: 1902 FRKLQHELEEAEERADIAESQVNKLR 1927
Score = 35.4 bits (80), Expect = 0.11
Identities = 62/360 (17%), Positives = 150/360 (41%), Gaps = 41/360 (11%)
Query: 60 KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETN---ERNLAHQELIKQKKDIS 116
++L ++ +++ ++ D L L RE ++ + + T E EL K KK +
Sbjct: 1481 RSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVE 1540
Query: 117 IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLD 176
+ Q+ E LE+ + +L ++ E N + K + K+ K E++D
Sbjct: 1541 QEKCELQAALEEAEASLEHEEGKILRIQLELNQV----------KSEVDRKIAEKDEEID 1590
Query: 177 VLEKECFRLT-TTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVS 235
L++ R+ + Q T + +I+ + ++ +K + +E++ L +
Sbjct: 1591 QLKRNHIRIVESMQSTLDAEIRSRNDAIR----LKKKMEGDLNEMEIQLNHAN------- 1639
Query: 236 NLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQ-HRDPHILQKPFNVTETR 294
+ + E ++ + T+ I + + + + E++ R ++LQ + E R
Sbjct: 1640 --RMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQA--EIEELR 1695
Query: 295 C-LPKPSRTTSWCKAIPPDSEKSISICDNLSELLM----AMQDELDQMSMEHQELLKQMK 349
L + R+ + D+ + + + + L+ ++ ++ QM E +++L++ +
Sbjct: 1696 ATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEAR 1755
Query: 350 ETE---SHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCK-LQQKVQNSKMSEASG 405
E ++ D E LKK + + ++KK+ + K LQ ++ ++ G
Sbjct: 1756 NAEEKAKKAITDAAMMAEE--LKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKG 1813
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 58.9 bits (141), Expect = 9e-09
Identities = 75/368 (20%), Positives = 146/368 (39%), Gaps = 38/368 (10%)
Query: 48 HSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQE 107
H + + + LQ ++ + ++E + E LN E + + + + Q+
Sbjct: 304 HEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQK 363
Query: 108 LIKQKKDISIQLSSAQS-RCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQM 166
L K +D+S Q +A+S RC+L +K E K + R++ + + K +
Sbjct: 364 LKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQ 423
Query: 167 KLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEI 226
+L +VL+ E +LT+ ++ E+ ++ ++KL E + Q K +EL+ +E
Sbjct: 424 ELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSME- 482
Query: 227 SKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQK 286
E KK + K + ++C L + + + Q ++ K
Sbjct: 483 ---------------EMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMK 527
Query: 287 PFNVTETRCL---------PKPSRTTSWCKAIPPDSEKSISICDNL----SELLMAMQDE 333
N ++ L + S T K D EK +L + + D+
Sbjct: 528 AKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDK 587
Query: 334 LDQMSMEHQELLK--QMKETESHSVCDD---IEC---ELECLLKKMEIKGEQISKLKKHQ 385
L + E + LL ++K+ E + ++ C E E LL +ME + E + H
Sbjct: 588 LSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHL 647
Query: 386 DSVCKLQQ 393
++ K QQ
Sbjct: 648 ETCLKTQQ 655
Score = 50.1 bits (118), Expect = 4e-06
Identities = 46/195 (23%), Positives = 86/195 (44%), Gaps = 28/195 (14%)
Query: 59 LKTLQEKIHRLELERTQAEDNLNILSREAAQY---KKALENETNERNLAHQELIKQKKDI 115
L+TL + L ++T ++ L L +++ K LEN+ + N + L+K+ + +
Sbjct: 2016 LQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESL 2075
Query: 116 SIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKL 175
+LS + +Y K LNV + L EK + ++L + E++
Sbjct: 2076 QARLSES-----------DYEK---LNVSKALEAALV-------EKGEFALRLSSTQEEV 2114
Query: 176 DVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEIS----KIIM 231
L + +L + E K H+ EKLKE E + +DK L+ L++S ++++
Sbjct: 2115 HQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVI 2174
Query: 232 SSVSNLKHSKEKKKS 246
N K E K+
Sbjct: 2175 LDAENSKAEVETLKT 2189
Score = 47.0 bits (110), Expect = 4e-05
Identities = 85/409 (20%), Positives = 172/409 (42%), Gaps = 71/409 (17%)
Query: 61 TLQEKIHRLELERTQAEDNLNILSREAAQYKKALEN-----ETNERNLAHQELI-----K 110
+L++K+ LE E +E+N ++ +A K +E E R+L EL
Sbjct: 2151 SLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRS 2210
Query: 111 QKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQ--------QAQLQREKE 162
+K++++ Q+ Q + + L+K L K ++ E+ + I E+ Q QL+ E
Sbjct: 2211 EKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNE 2270
Query: 163 Q------DQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEK-------LKEEEHQ 209
DQ + A + LD +E +L + + +++ E+K LKE EH
Sbjct: 2271 AVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHH 2330
Query: 210 RKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSK-KTKCIKRRPPWQICSKFG-A 267
L + + L+ LEI++ +N +H+ + ++SK + + +K + S G
Sbjct: 2331 ADLLKGRVENLERELEIAR------TNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLE 2384
Query: 268 LPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELL 327
L V + + + LQK + R +S+ + ++ + + + S +
Sbjct: 2385 LDVVTIRSEKENLTNELQK----EQERISELEIINSSFENILQEKEQEKVQMKEKSSTAM 2440
Query: 328 MAMQDELDQM-----SMEHQELLKQMKETESHSVCDDIECELECLLKKM-EIKGEQI--- 378
+Q +L ++ ++ + + + KE S + +E E LL+ + E K I
Sbjct: 2441 EMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQ 2500
Query: 379 --------------SKLKKHQDSVCKLQQKVQN-----SKMSEASGIQQ 408
KL+K + + +L+ ++Q+ SK+S+ G Q
Sbjct: 2501 SSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQ 2549
Score = 46.2 bits (108), Expect = 6e-05
Identities = 85/382 (22%), Positives = 160/382 (41%), Gaps = 61/382 (15%)
Query: 59 LKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLA---HQEL-IKQKKD 114
L+ E+I RL+ + E ++ LS+ +++ E RNL Q++ + Q K+
Sbjct: 2517 LEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKN 2576
Query: 115 ISIQ--LSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKL 172
S+Q L QS LE +LE TK ++ + N + ++ +LQRE + K
Sbjct: 2577 ASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQ 2636
Query: 173 EKL----DVLEKECFRLTTTQKTAEDKIKHL---------------------EEKLKEE- 206
E+L + L E L K+++D++K L E K++EE
Sbjct: 2637 EELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEI 2696
Query: 207 -EHQRKLFQDKASELQTGLEISKIIMSSVSNLKH---SKEKKKSSKKTKC-IKRRPPWQI 261
E+Q +L + + L+ +K + + SKE+ SS+K + + + ++
Sbjct: 2697 AEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEEL 2756
Query: 262 CSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPS-RTTSWCKAIPPDSEKSISIC 320
+ A + E++++ K N+ L K + R K + I C
Sbjct: 2757 NNSLKATTQILEELKK-------TKMDNLKYVNQLKKENERAQGKMKLL-------IKSC 2802
Query: 321 DNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISK 380
L E +Q EL Q+ + KQ T + D++ E++ L + +E E+ +
Sbjct: 2803 KQLEEEKEILQKELSQLQAAQE---KQKTGTVMDTKVDELTTEIKELKETLE---EKTKE 2856
Query: 381 LKKHQDSVCKL---QQKVQNSK 399
++ D C L +K++ +K
Sbjct: 2857 ADEYLDKYCSLLISHEKLEKAK 2878
Score = 41.6 bits (96), Expect = 0.002
Identities = 71/353 (20%), Positives = 146/353 (41%), Gaps = 54/353 (15%)
Query: 99 NERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQ 158
+ER+ E + K+ +I Q+R LE LE K+M +++++ +++ + +++
Sbjct: 809 SERSECRLEADQSPKNSAI----LQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIE 864
Query: 159 RE-KEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKA 217
+ +QM E + K + Q + + LE K KE + + +
Sbjct: 865 ENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQ 924
Query: 218 SELQTGLEISKIIMSSVSNLKHSKE----KKKSSKKTKCIKRRPPWQICSKFGALPFVAE 273
+E+Q + + ++ S+ L+ E +KK + +R ++ + G L +
Sbjct: 925 AEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINA 984
Query: 274 KMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSIS-ICDNLSELLMAMQD 332
+ Q + +++QK + S+ I + EKSIS + D + + +
Sbjct: 985 SLNQEK-MNLIQK---------------SESFANYID-EREKSISELSDQYKQEKLILLQ 1027
Query: 333 ELDQMSMEHQELLKQMK---ETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVC 389
++ +++L ++ K E S C EC C +K E++ + + K+HQ+ +
Sbjct: 1028 RCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLT 1087
Query: 390 KL-----------------QQKV-------QNSKMSEASGIQQEDSYPKGSKN 418
KL QQ + QN+ SEA G++QE K +N
Sbjct: 1088 KLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQN 1140
Score = 40.8 bits (94), Expect = 0.003
Identities = 68/335 (20%), Positives = 155/335 (46%), Gaps = 42/335 (12%)
Query: 51 NSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNER---NLAHQE 107
+SQAL L L+ +I +L E+ +L +E+ + L E+ + A +
Sbjct: 2043 DSQALSLTKCELENQIAQLNKEK-------ELLVKESESLQARLSESDYEKLNVSKALEA 2095
Query: 108 LIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMK 167
+ +K + +++LSS Q L + +E R+ + + +K + + ++ + +RE+E D +K
Sbjct: 2096 ALVEKGEFALRLSSTQEEVHQLRRGIE-KLRVRIEADEKKQLHIAEKLK-ERERENDSLK 2153
Query: 168 LYAKLEKLDVLEKECFRLTTTQ-------KTAEDKIKHLEEKLKEEEHQRKLFQDKASEL 220
+K++ LE+E Q + ++ +++ L+ +++E K+F+ L
Sbjct: 2154 -----DKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTL 2208
Query: 221 QTGLE-ISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHR 279
++ E ++K I L + S K K + QI + A +M Q++
Sbjct: 2209 RSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEE----SKTAVEMLQNQ 2264
Query: 280 DPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQ-DELDQMS 338
+ + + + + K + +++ P E+ + +++ +L ++ DE Q+
Sbjct: 2265 LKELNEAVAALCGDQEIMKATE-----QSLDPPIEEEHQLRNSIEKLRARLEADEKKQLC 2319
Query: 339 MEHQELLKQMKETESHSVCDDIECELECLLKKMEI 373
+L+Q+KE+E H+ D ++ +E L +++EI
Sbjct: 2320 -----VLQQLKESEHHA--DLLKGRVENLERELEI 2347
Score = 37.0 bits (84), Expect = 0.038
Identities = 66/321 (20%), Positives = 120/321 (37%), Gaps = 49/321 (15%)
Query: 96 NETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQA 155
N+ NE + L +K ++ +L+ ++S C +++ +LN E ++ +
Sbjct: 1298 NKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLN---EVKILNDDSG 1354
Query: 156 QLQREK----------EQDQMKLYAKLEKLDVLEKECFR-LTTTQKTAEDKIKHLEEKLK 204
L E EQ + L LD E + LT + K + L+EK
Sbjct: 1355 LLHGELVEDIPGGEFGEQPNEQHPVSLAPLD--ESNSYEHLTLSDKEVQMHFAELQEKFL 1412
Query: 205 EEEHQRKLFQD-------KASELQTGLEISK----IIMSSVSNLKHSKEKKKS------- 246
+ + K+ D K SELQT ++ K ++ +++ N + K+
Sbjct: 1413 SLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGL 1472
Query: 247 --SKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQK--------PFNVTETRCL 296
S + C+ P S G F + Q D +L +V E C
Sbjct: 1473 VPSLSSSCV---PDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCS 1529
Query: 297 PKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSV 356
+ K P K + ++L E+ ++L++ ME Q ++K + E +
Sbjct: 1530 SLQEENLTR-KETPSAPAKGVEELESLCEVYRQSLEKLEE-KMESQGIMKNKEIQELEQL 1587
Query: 357 CDDIECELECLLKKMEIKGEQ 377
EL+CL K+ + EQ
Sbjct: 1588 LSSERQELDCLRKQYLSENEQ 1608
Score = 35.8 bits (81), Expect = 0.084
Identities = 92/410 (22%), Positives = 164/410 (40%), Gaps = 56/410 (13%)
Query: 49 SPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKA---LENETNERNLAH 105
S + + L L+ K L+L D + E + KK+ LE+ E L
Sbjct: 893 SAHQNVVAETLSALENKEKELQL----LNDKVETEQAEIQELKKSNHLLEDSLKELQLLS 948
Query: 106 QELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQL-----QRE 160
+ L +KK++S +S + L ++ K + ++ +EK ++++ +RE
Sbjct: 949 ETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDERE 1008
Query: 161 KEQDQMKLYAKLEKLDVLEKECFR-------LTTTQKTAEDKIKHLEEKLKE-----EEH 208
K ++ K EKL +L++ C L+ K A++K LE L E E
Sbjct: 1009 KSISELSDQYKQEKLILLQR-CEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENR 1067
Query: 209 QRKLFQDK---ASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKF 265
+ +L Q K A E Q L NL E + + +++ Q SK
Sbjct: 1068 KNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDN----QNNSKS 1123
Query: 266 GALPFVAEKMRQHRDPHILQKPFN--VTETRCLPKPSRTTSWCKAIPPDSEKSISICDNL 323
A E M + + +QK N + E L K +T C+ + +S I +++
Sbjct: 1124 EAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNL-----ESEPIRNSV 1178
Query: 324 SELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLK- 382
E + E +Q + + Q L ++KE S + +LE +L+ E+K ++ K K
Sbjct: 1179 KE----RESERNQCNFKPQMDL-EVKEISLDSYNAQL-VQLEAMLRNKELKLQESEKEKE 1232
Query: 383 --KHQDSVCK---LQQKVQNSKMSEASG-----IQQEDSYPKGSKNIKNS 422
+H+ + +Q+ + E SG I E+ Y G + S
Sbjct: 1233 CLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTS 1282
Score = 35.0 bits (79), Expect = 0.14
Identities = 57/277 (20%), Positives = 112/277 (40%), Gaps = 38/277 (13%)
Query: 107 ELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQM 166
+L K+K+ QL S ++ ++++E K N++RE ++E L++ K++
Sbjct: 29 KLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISH 88
Query: 167 KLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLE- 225
+L K +++ E + + + +I+ LE++LK + + + Q A L
Sbjct: 89 ELQVKESQVNFQEGQL-------NSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNP 141
Query: 226 ---ISKIIMSSV------SNLKHSKEKKKSSKKTKCIKR-RPPWQICSKFGALPFVAEKM 275
KI + + S K+ K+K +K+ + KR + A + +
Sbjct: 142 CNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQAT 201
Query: 276 RQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSIS-------ICDNLSELLM 328
HRD Q +V + PS +S + P + S S + + S L +
Sbjct: 202 MNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQI 261
Query: 329 AMQDE-------------LDQMSMEHQELLKQMKETE 352
+D LDQ+ ++QEL ++ E E
Sbjct: 262 GKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELE 298
Score = 32.3 bits (72), Expect = 0.93
Identities = 29/156 (18%), Positives = 67/156 (42%)
Query: 65 KIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQS 124
++H + R DN+ ++ + +ENE + + + + L Q+
Sbjct: 1871 EMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQT 1930
Query: 125 RCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFR 184
LEK E +++++ +E E +++ ++ QL+ E + K A + + ++++
Sbjct: 1931 EKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQE 1990
Query: 185 LTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASEL 220
L + Q I+ E ++KE+ + SEL
Sbjct: 1991 LESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSEL 2026
Score = 29.6 bits (65), Expect = 6.0
Identities = 62/341 (18%), Positives = 126/341 (36%), Gaps = 42/341 (12%)
Query: 144 EREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHL---- 199
+R+ +L + +L + +++L K+E LEK L +K+++
Sbjct: 1794 DRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDH 1853
Query: 200 EEKLKEEEHQR------KLFQDKASELQTGLEISKIIMS------SVSNLKHSKEKKKSS 247
+E L+ E ++ DK+S G ++K+ S V N +K+S
Sbjct: 1854 QELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKAS 1913
Query: 248 KKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCK 307
+ + + ++ EK+ +D QK E S
Sbjct: 1914 IEHEALYLEADLEVVQ--------TEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRG 1965
Query: 308 AIPPDSEKSISICDNLSELLMAMQDELDQMSME--HQELLKQMKETESHSVCDDIECELE 365
+ S+K+ ++ D LSE + EL+ E H + + + E + + ++
Sbjct: 1966 ELDTMSKKTTAL-DQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVS 2024
Query: 366 CLLKKMEIKGEQISKLKKHQDSV----CKLQQKV------QNSKMSEASGIQ---QEDSY 412
LLK E++ L+K ++ C+L+ ++ + + E+ +Q E Y
Sbjct: 2025 ELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDY 2084
Query: 413 PKGSKNIKNSPRKCLTDTNLFQKNSSFHPIRVHNLQMKLRR 453
K N+ + L + F S VH L+ + +
Sbjct: 2085 EK--LNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEK 2123
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 58.5 bits (140), Expect = 1e-08
Identities = 76/395 (19%), Positives = 169/395 (42%), Gaps = 32/395 (8%)
Query: 59 LKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQK------ 112
L LQEK H L+ + TQ + L S Q ++ L ++ E+ AH + +
Sbjct: 563 LNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQK-AHLRAAQDRVLSLET 621
Query: 113 --KDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQ----------RE 160
+++ QL+ ++ + + L+ Q++ ++L+ E K Q+A LQ ++
Sbjct: 622 SVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKT---AQRADLQNHLDTAQNALQD 678
Query: 161 KEQDQMKLYAKLE----KLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQ-RKLFQD 215
K+Q+ K+ +L+ KL ++ C +L + K ++K LE+K +E E Q +KL D
Sbjct: 679 KQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAD 738
Query: 216 ----KASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFV 271
KAS+ Q ++ + + + E K + K I + K AL +
Sbjct: 739 SLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESI 798
Query: 272 AEKM-RQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAM 330
+K+ +Q + IL++ F + + + + +K + L L +
Sbjct: 799 KQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTV 858
Query: 331 QDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCK 390
+D+L ++S + + ++ ++ E C K +++ + + LK+ ++
Sbjct: 859 KDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKS 918
Query: 391 LQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRK 425
L+++ + S + ++ + +K + ++
Sbjct: 919 LEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953
Score = 48.5 bits (114), Expect = 1e-05
Identities = 76/388 (19%), Positives = 160/388 (41%), Gaps = 64/388 (16%)
Query: 63 QEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSA 122
++++ L+L+ ++ E+ L +E L+++ ++ HQE ++ + +L A
Sbjct: 452 EQQVADLQLKLSRLEEQL----KEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREA 507
Query: 123 QSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKL---------- 172
Q+ + +Q+ + + N+E E + L++E+E LYAK+
Sbjct: 508 QNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERED----LYAKIQAGEGETAVL 563
Query: 173 ----EKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISK 228
EK L+++ +LT K + K +E L ++ ++K A + LE S
Sbjct: 564 NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV 623
Query: 229 IIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPF 288
++S N + K+K S+ IK + + ++ A K Q D LQ
Sbjct: 624 NELNSQLN----ESKEKVSQLDIQIKAKTELLLSAE-------AAKTAQRAD---LQNHL 669
Query: 289 NVTETRCLPKP---SRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELL 345
+ + K ++ T+ + + C L L +++ + + +EL
Sbjct: 670 DTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELE 729
Query: 346 KQMKETESHS-------------------VCDDIECELECLLKKMEIKGEQISK----LK 382
Q+K+ E+ S + D+E L K++E++ E +S L+
Sbjct: 730 GQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQ 789
Query: 383 KHQDSVCKLQQKVQNSKMSEASGIQQED 410
K +++ ++QK+ +K E I ++D
Sbjct: 790 KKSEALESIKQKL--TKQEEEKQILKQD 815
Score = 45.1 bits (105), Expect = 1e-04
Identities = 77/363 (21%), Positives = 155/363 (42%), Gaps = 48/363 (13%)
Query: 35 HPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKAL 94
H LE+ S + + LI A TL++ E E Q + N+N L + + Q KK +
Sbjct: 927 HQLKLELNSMQ-------EQLIQAQNTLKQN----EKEEQQLQGNINELKQSSEQKKKQI 975
Query: 95 ENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQ 154
E E +A + + + + QL+ A E E K VL EK+ E
Sbjct: 976 EALQGELKIAVLQKTELENKLQQQLTQAAQ-----ELAAEKEKISVLQNNYEKSQ--ETF 1028
Query: 155 AQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQ 214
QLQ + + +L A + L +E++ + ++I + + ++E + + +
Sbjct: 1029 KQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLE 1088
Query: 215 DKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEK 274
+++ + L+ + + K KEK+ ++K+K + C + + + E+
Sbjct: 1089 QDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEE--IKCRQEKEITKLNEE 1146
Query: 275 MRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDEL 334
++ H+ I ++ N+ + + L + KA DS K+ + ++ ++
Sbjct: 1147 LKSHKLESI-KEITNLKDAKQLLIQQKLELQGKA---DSLKAAVEQEKRNQQILK----- 1197
Query: 335 DQMSMEHQELLKQM--KETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQ 392
DQ+ E +EL K+ KE + HS EIK +++ +KKH+++ KL
Sbjct: 1198 DQVKKEEEELKKEFIEKEAKLHS----------------EIKEKEVG-MKKHEENEAKLT 1240
Query: 393 QKV 395
++
Sbjct: 1241 MQI 1243
Score = 40.8 bits (94), Expect = 0.003
Identities = 68/351 (19%), Positives = 141/351 (40%), Gaps = 47/351 (13%)
Query: 59 LKTLQEKIHRLELERTQAEDNLNILSREAAQY-------KKALENETNERNLAHQELIKQ 111
L++L++++ + E + ++ ++AAQ K + E + R A Q++ +
Sbjct: 137 LQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRL 196
Query: 112 KKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAK 171
++++ + + Q T L ++ VL E + L L+RE+E +++K
Sbjct: 197 TEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLK---- 252
Query: 172 LEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGL-EISKII 230
EC +L + ++E I L +L + + ++ + +L++ + E+++
Sbjct: 253 --------DECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKN 304
Query: 231 MSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNV 290
+ NL KK TK ++ + K A ++ D LQ +
Sbjct: 305 QTLTENL-----LKKEQDYTKLEEKHNEESVSKK----NIQATLHQKDLDCQQLQSRLSA 355
Query: 291 TETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKE 350
+ET I + + L E L ++ + + E ++L +Q +E
Sbjct: 356 SETS-----------LHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREE 404
Query: 351 TESHSVCDDIECELECLLKKM----EIKGEQISKLK-KHQDSVCKLQQKVQ 396
E H + ++ E+ L K+ GE +LK + Q S KL K Q
Sbjct: 405 KEQHGL--QLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ 453
Score = 39.7 bits (91), Expect = 0.006
Identities = 63/369 (17%), Positives = 157/369 (42%), Gaps = 40/369 (10%)
Query: 53 QALILALKTLQEKIHRLE--LERTQAEDNLNILSREAA--QYKKALENETNERNLAHQEL 108
+AL+ L T+++K+ ++ L+ +++E +AA +K + ++ + +
Sbjct: 849 EALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENT 908
Query: 109 IKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKL 168
+K++K++ L + L+ +L + ++ + +++ QLQ + +
Sbjct: 909 LKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSS 968
Query: 169 YAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISK 228
K ++++ L+ E ++ QKT + L+++L + + ++K S LQ E S+
Sbjct: 969 EQKKKQIEALQGE-LKIAVLQKTELE--NKLQQQLTQAAQELAAEKEKISVLQNNYEKSQ 1025
Query: 229 IIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPF 288
+ + + +E + + + L V EK+ ++ I +
Sbjct: 1026 ETFKQLQSDFYGRESELLATRQD----------------LKSVEEKLSLAQEDLISNRNQ 1069
Query: 289 NVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQM 348
+ + + + + + DS K L E A+QD + S++ +EL +
Sbjct: 1070 IGNQNKLIQELKTAKA---TLEQDSAKKE---QQLQERCKALQDIQKEKSLKEKEL---V 1120
Query: 349 KETESHSVCDDIECELECLLKKM--EIKG------EQISKLKKHQDSVCKLQQKVQNSKM 400
E + ++I+C E + K+ E+K ++I+ LK + + + + ++Q
Sbjct: 1121 NEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKAD 1180
Query: 401 SEASGIQQE 409
S + ++QE
Sbjct: 1181 SLKAAVEQE 1189
Score = 39.3 bits (90), Expect = 0.008
Identities = 85/381 (22%), Positives = 155/381 (40%), Gaps = 77/381 (20%)
Query: 57 LALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDIS 116
LALK + R E++ QA +E Y + L+ E + Q+ + K D
Sbjct: 78 LALKRDDVTLLRQEVQDLQAS------LKEEKWYSEELKKELEKYQGLQQQ--EAKPDGL 129
Query: 117 IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLD 176
+ SSA+ + LE+QLE + N+++ K++ ++ AQL E + K Y + L
Sbjct: 130 VTDSSAELQS--LEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSK-YDEERSL- 185
Query: 177 VLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASEL--QTGLEISKI----- 229
++ AE K+ L E+L +E + QD +EL + G+E +
Sbjct: 186 ------------REAAEQKVTRLTEELNKE---ATVIQDLKTELLQRPGIEDVAVLKKEL 230
Query: 230 --IMSSVSNLKHSKEKKKSSKKTKCIKRRPPW--------QICSKFGALP-----FVAEK 274
+ + + N+ +E++ K +C K + + Q+ S+ P +V E
Sbjct: 231 VQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQEL 290
Query: 275 MRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDEL 334
+ + L + N T T L K + + K +E+S+S +Q L
Sbjct: 291 QKLKSSVNELTQK-NQTLTENLLK--KEQDYTKLEEKHNEESVS--------KKNIQATL 339
Query: 335 DQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLK--------KHQD 386
Q ++ Q+L ++ +E+ L + ++ KGE KLK K+Q
Sbjct: 340 HQKDLDCQQLQSRLSASET---------SLHRIHVELSEKGEATQKLKEELSEVETKYQH 390
Query: 387 SVCKLQQKVQNSKMSEASGIQ 407
+ +Q Q + E G+Q
Sbjct: 391 LKAEFKQLQQQREEKEQHGLQ 411
Score = 32.7 bits (73), Expect = 0.71
Identities = 75/361 (20%), Positives = 143/361 (39%), Gaps = 69/361 (19%)
Query: 52 SQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQ 111
+Q L L ++ K L+ E Q + E Q+ L++E N+ H +L++
Sbjct: 374 TQKLKEELSEVETKYQHLKAEFKQLQQQ----REEKEQHGLQLQSEINQ---LHSKLLET 426
Query: 112 KKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAK 171
++ QL A R L++Q + + +++ E++ + + Q +L R +EQ + K+
Sbjct: 427 ER----QLGEAHGR---LKEQRQLSSEKLMDKEQQ---VADLQLKLSRLEEQLKEKV--- 473
Query: 172 LEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQD----KASELQTGLE-I 226
T +++H +K K++ +++ Q K E Q LE +
Sbjct: 474 -------------------TNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQV 514
Query: 227 SKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDP-HILQ 285
+ I +++ + + SK+ + + + +K A + Q ++ H LQ
Sbjct: 515 LRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQ 574
Query: 286 KPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSEL-------LMAMQDELDQMS 338
+ + T + + SE +NL + L A QD + +
Sbjct: 575 E--------------QVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLE 620
Query: 339 MEHQELLKQMKET-ESHSVCD-DIECELECLLKKMEIKGEQISKLKKHQDSVCK-LQQKV 395
EL Q+ E+ E S D I+ + E LL K Q + L+ H D+ LQ K
Sbjct: 621 TSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQ 680
Query: 396 Q 396
Q
Sbjct: 681 Q 681
>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
Length = 1094
Score = 58.5 bits (140), Expect = 1e-08
Identities = 77/368 (20%), Positives = 160/368 (43%), Gaps = 38/368 (10%)
Query: 59 LKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALE---NETNERNLAHQELIKQKKDI 115
LK +Q E ER A+ ++ L+R A K E +E + +E K+++D+
Sbjct: 423 LKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDL 482
Query: 116 SIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKL 175
++ + + L K+LE R + + + + Q+ +EK++ + +LYA L+++
Sbjct: 483 KLKAQESIRQWKLKHKKLE---RALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQI 539
Query: 176 DVLEKECFRLTTTQKTAEDKIKHLEEKLKE-EEHQRKLFQD----------------KAS 218
+ L KE + T + E+++ EEKL++ + HQ L + K S
Sbjct: 540 ENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQS 599
Query: 219 ELQTGLEISKI-IMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKM-R 276
++Q+ +++ K + ++ LK K ++ K K ++ + + S A +A K+
Sbjct: 600 KIQSQMKVEKAHLEEEIAELK----KSQAQDKAKLLEMQESIKDLSAIRA--DLANKLAE 653
Query: 277 QHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQ 336
+ R + K + + + T + + + + L +L ++Q +
Sbjct: 654 EERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQR---ELKDLTSSLQSVKTK 710
Query: 337 MSMEHQELLKQMKETESHSVCDDIECELECLLKK--MEIKGEQISKLKKHQDSVCK--LQ 392
QEL+K K+ +S + + E L +K +I Q+ KLK D + + Q
Sbjct: 711 HEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQ 770
Query: 393 QKVQNSKM 400
+ +N K+
Sbjct: 771 NENENKKL 778
Score = 55.5 bits (132), Expect = 1e-07
Identities = 75/362 (20%), Positives = 154/362 (42%), Gaps = 46/362 (12%)
Query: 45 KILHSPNSQALILALKTLQE---KIHRLELERTQAEDNLNILSREAAQYKKALENETNER 101
K+ H +AL +T+ E K +++ E+ + + L ++ +K L + +R
Sbjct: 494 KLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKR 553
Query: 102 NLAHQELIKQKK----------DISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMIL 151
L +EL +++ D+ +++ ++ LE +L+ ++ ++ EK +
Sbjct: 554 ALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLE 613
Query: 152 EQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKI--KHLEEKLKEEEHQ 209
E+ A+L++ + QD+ KL E + L R K AE++ K + + L + Q
Sbjct: 614 EEIAELKKSQAQDKAKLLEMQESIKDLS--AIRADLANKLAEEERAKKAVLKDLSDLTAQ 671
Query: 210 RKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALP 269
K ++ + + T L++ + + H +E K + + +K + I
Sbjct: 672 AKSRDEETATIITQLKLERDV--------HQRELKDLTSSLQSVKTKHEQNIQELMKHF- 722
Query: 270 FVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMA 329
+K + + HI E + + K R EK S CD L+E L
Sbjct: 723 ---KKEKSEAENHIRTLKAESLEEKNMAKIHRG---------QLEKLKSQCDRLTEELTQ 770
Query: 330 MQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIK---GEQISKLKKHQD 386
++E ++ +++Q L Q++E E H I E E L + E + +Q+ L+ Q+
Sbjct: 771 NENENKKLKLKYQCLKDQLEEREKH-----ISIEEEHLRRMEEARLQLKDQLLCLETEQE 825
Query: 387 SV 388
S+
Sbjct: 826 SI 827
Score = 54.3 bits (129), Expect = 2e-07
Identities = 81/403 (20%), Positives = 157/403 (38%), Gaps = 67/403 (16%)
Query: 27 QNEPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSRE 86
Q E +N LE++ + S S+ +TL ++ L + T+AE + L +
Sbjct: 276 QTETEKNQLEQELELSRRLLNQSEGSR------ETLLHQVEELRTQLTKAEGDRKGLQHQ 329
Query: 87 AAQYKKALENETNERN----------LAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYT 136
+Q K N +E+ Q+L KQ D+ +QL+ + + +LE
Sbjct: 330 VSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSA-----MASELEEV 384
Query: 137 KRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKI 196
KR + ++EK + Q L RE E + + L++L ++ +K A+ +I
Sbjct: 385 KRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQI 444
Query: 197 KHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRR 256
L ++ Q + + SELQ LK EK++ K K +
Sbjct: 445 SELTRHAEDATKQAERY---LSELQQS-----------EALKEEAEKRREDLKLKAQESI 490
Query: 257 PPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKS 316
W++ K K+ R L K S T + + +
Sbjct: 491 RQWKLKHK---------KLE-----------------RALEKQSETVD---ELTGKNNQI 521
Query: 317 ISICDNLSELLMAMQDELDQMSMEHQELL--KQMKETESHSVCDDIECELECLLKKMEIK 374
+ D L L A +++ + E ++L + ++E E HS + + +++ +E++
Sbjct: 522 LKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLR-DIKSHQADLELE 580
Query: 375 GEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSK 417
+ +S K Q K+Q+ E + +++E + K S+
Sbjct: 581 VKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQ 623
Score = 46.2 bits (108), Expect = 6e-05
Identities = 86/418 (20%), Positives = 167/418 (39%), Gaps = 80/418 (19%)
Query: 69 LELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTL 128
LELE + D ++ L E + K E+ +E+ + KK S AQ + L
Sbjct: 577 LELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKK------SQAQDKAKL 630
Query: 129 LEKQLEYTKRMVLNV---------EREKNMILEQQAQL-----QREKEQDQMKLYAKLEK 174
LE Q + ER K +L+ + L R++E + KLE+
Sbjct: 631 LEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLER 690
Query: 175 LDVLEKECFRLTTTQKTAEDK--------IKHLE-EKLKEEEHQRKLFQDKASELQTGLE 225
DV ++E LT++ ++ + K +KH + EK + E H R L KA L+
Sbjct: 691 -DVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTL---KAESLEEK-N 745
Query: 226 ISKIIMSSVSNLK------------HSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAE 273
++KI + LK + E KK K +C+K Q+ + + E
Sbjct: 746 MAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKD----QLEEREKHISIEEE 801
Query: 274 KMRQHRDPHILQKPFNVTETRCLPKPSRTT---------SWCKAIPPDSEKSISICDNLS 324
+R+ + + K + CL + + CK DS + + + +
Sbjct: 802 HLRRMEEARLQLKD----QLLCLETEQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGP 857
Query: 325 ELLMAMQDELDQMSMEHQELLKQMKETESH----------------SVCDDIECELECLL 368
++ L + + Q L +++KE E+ ++ ++ E EL+CL
Sbjct: 858 DIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLF 917
Query: 369 KKMEIKGEQISKL-KKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRK 425
+++E + + + ++ ++ +D + + Q+K + + I E S ++++ P K
Sbjct: 918 QQIERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRVIALETSTQVALDHLESVPEK 975
Score = 40.0 bits (92), Expect = 0.004
Identities = 37/157 (23%), Positives = 68/157 (43%), Gaps = 15/157 (9%)
Query: 95 ENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQ 154
E E E+NL HQ L+ ++ + + +S L +Q+E ++++ + REK +LE+
Sbjct: 883 ERENREKNLRHQ-LMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEET 941
Query: 155 AQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQ 214
+ K E++ L+ L T+ + A D ++ + EKL E +
Sbjct: 942 QR--------------KDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLLEDFKDFRD 987
Query: 215 DKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTK 251
+S +T SK + S H + K +K K
Sbjct: 988 SCSSSERTDGRYSKYRVRRNSLQHHQDDTKYRTKSFK 1024
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 58.5 bits (140), Expect = 1e-08
Identities = 38/152 (25%), Positives = 78/152 (51%), Gaps = 9/152 (5%)
Query: 102 NLAHQELIKQKKDISIQLSSAQSRCTL--LEKQLEYTKRMVLNVEREKNMILEQQAQLQR 159
N+ H +K I L SA++ + ++++ E TK + E ++ + E+ L +
Sbjct: 827 NVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQ 886
Query: 160 EKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH-------QRKL 212
EK Q+++ A+ + L E+ C +L T+ E KIK + E+ ++EE +++
Sbjct: 887 EKNDLQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK 946
Query: 213 FQDKASELQTGLEISKIIMSSVSNLKHSKEKK 244
+D+ SEL+ ++ ++ ++ V KH+ E K
Sbjct: 947 LEDECSELKKDIDDLELTLAKVEKEKHATENK 978
Score = 46.2 bits (108), Expect = 6e-05
Identities = 62/326 (19%), Positives = 138/326 (42%), Gaps = 32/326 (9%)
Query: 68 RLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCT 127
++E + + E LN +R+AA+ AL N N + + KD + L A
Sbjct: 1621 KMEGDLNEMEIQLNHANRQAAE---ALRNLRNTQGIL--------KDTQLHLDDAIRGQD 1669
Query: 128 LLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTT 187
L++QL +R ++ E + + +R ++ + +L E++ +L + L
Sbjct: 1670 DLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLIN 1729
Query: 188 TQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTG----LEISKIIMSSVSNLKHSKEK 243
T+K E I ++ ++++ + + ++KA + T E K + ++L+ K+
Sbjct: 1730 TKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1789
Query: 244 KKSSKKTKCIKRRPPWQICSKFG--ALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSR 301
+ + K ++ Q+ K G + + ++R+ ++ NV + L K R
Sbjct: 1790 MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHER 1849
Query: 302 TTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCD--- 358
+ K+I + +QD +D++ + + +Q +E E S +
Sbjct: 1850 RVKELTYQTEEDRKNI----------LRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAK 1899
Query: 359 --DIECELECLLKKMEIKGEQISKLK 382
++ ELE ++ +I Q++KL+
Sbjct: 1900 FRKLQHELEEAKERADIAESQVNKLR 1925
Score = 44.3 bits (103), Expect = 2e-04
Identities = 45/198 (22%), Positives = 87/198 (43%), Gaps = 6/198 (3%)
Query: 53 QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQK 112
QA AL +E+ +L + Q E + ++ A ++ T ++ E + K
Sbjct: 896 QAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 955
Query: 113 KDIS-IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAK 171
KDI ++L+ A+ +EK+ T+ V N+ E + E A+L +EK+ Q
Sbjct: 956 KDIDDLELTLAK-----VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT 1010
Query: 172 LEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIM 231
L+ L + E + LT + E ++ LE L++E+ + +L+ L++++
Sbjct: 1011 LDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQEST 1070
Query: 232 SSVSNLKHSKEKKKSSKK 249
N K +K K+
Sbjct: 1071 MDTENDKQQLNEKLKKKE 1088
Score = 41.2 bits (95), Expect = 0.002
Identities = 41/203 (20%), Positives = 91/203 (44%), Gaps = 26/203 (12%)
Query: 63 QEKIHRLELERTQAEDNLNILSREAAQYKKALENE----TNERNLAHQELIKQKKDISIQ 118
+E+ + EL+R ++ N E AQ++ E + T E A ++L ++ +D
Sbjct: 1353 EEQEAKAELQRGMSKAN-----SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEH 1407
Query: 119 LSSAQSRCTLLEKQLEYTKR----MVLNVEREKNMIL----------EQQAQLQREKEQD 164
+ + S+C LEK + + ++++VER + + A+ +++ E+
Sbjct: 1408 VEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEET 1467
Query: 165 QMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGL 224
Q +L A ++ L E F++ + E+ + HLE +E ++ ++ D ++ G
Sbjct: 1468 QAELEASQKESRSLSTELFKV---KNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGG 1524
Query: 225 EISKIIMSSVSNLKHSKEKKKSS 247
+ + L H K + ++S
Sbjct: 1525 KHIHELEKVKKQLDHEKSELQTS 1547
Score = 40.4 bits (93), Expect = 0.003
Identities = 47/195 (24%), Positives = 85/195 (43%), Gaps = 27/195 (13%)
Query: 51 NSQALILAL----KTLQEKIHRLELE-------RTQAEDNLNILSREAAQYKKALEN--- 96
+ QAL + L K LQ +I LE E R +AE + LSRE + + LE
Sbjct: 1100 DEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGG 1159
Query: 97 ------ETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMI 150
E N++ A E K ++D+ ++ L K+ + V + + + +
Sbjct: 1160 ATSAQIEMNKKREA--EFQKMRRDLEESTLQHEATAAALRKKHADS---VAELGEQIDSL 1214
Query: 151 LEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQR 210
+ +L++EK + +M++ ++ + K +T ED++ E K KEEE QR
Sbjct: 1215 QRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLS--EIKTKEEEQQR 1272
Query: 211 KLFQDKASELQTGLE 225
+ + A + + E
Sbjct: 1273 LINELSAQKARLHTE 1287
Score = 37.7 bits (86), Expect = 0.022
Identities = 33/149 (22%), Positives = 68/149 (45%), Gaps = 14/149 (9%)
Query: 60 KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETN---ERNLAHQELIKQKKDIS 116
++L ++ +++ ++ D+L L RE ++ + + T E EL K KK +
Sbjct: 1479 RSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLD 1538
Query: 117 IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLD 176
+ S Q+ E LE+ + +L ++ E N + K + K+ K E+LD
Sbjct: 1539 HEKSELQTSLEEAEASLEHEEGKILRIQLELNQV----------KSEIDRKIAEKDEELD 1588
Query: 177 VLEKECFRLT-TTQKTAEDKIKHLEEKLK 204
L++ R+ + Q T + +I+ + L+
Sbjct: 1589 QLKRNHLRVVESMQSTLDAEIRSRNDALR 1617
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens]
Length = 1116
Score = 58.2 bits (139), Expect = 2e-08
Identities = 84/424 (19%), Positives = 185/424 (43%), Gaps = 77/424 (18%)
Query: 59 LKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQ 118
+ +L+E++ L+ + T + L L A+ ++ +E +R+ +E ++ +
Sbjct: 594 MSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKD 653
Query: 119 LSSAQSRCTLLEKQLEYTKRMVLNVEREKNMI----LEQQAQLQ------REKEQDQMKL 168
L + + +LL+ L + +L+++ + + L++ ++L+ +K+++ +K+
Sbjct: 654 LKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKM 713
Query: 169 YAKLEK-----------------LDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRK 211
++L+K + LE+E R A+ ++ L E LKE E+++
Sbjct: 714 ESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKN 773
Query: 212 LFQDKASELQTGLEISKIIMSSVSNLKHSK--EKKKSSKKTKCIKRRPPWQICSKFGALP 269
K +EL+ ++ V+NLKH + EKKKS++ + +RR
Sbjct: 774 DKDKKIAELERQVKDQN---KKVANLKHKEQVEKKKSAQMLEEARRRE-----------D 819
Query: 270 FVAEKMRQHRDPHILQKPFNVTE-TRCLPKPSRTTSWCKAIPPDSEKSISICD-NLSELL 327
+ + +Q +D + +K + E L + + T+ + + E + + + + ELL
Sbjct: 820 NLNDSSQQLQD-SLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELL 878
Query: 328 MAMQ---DELDQMSMEHQELLKQMKETESH----------SVCDDIECELECLLKKMEIK 374
MAM+ EL+ M + + + E E+H + + +E + E LL + K
Sbjct: 879 MAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEK 938
Query: 375 G----------------EQISKLKKHQDS-VCKLQQKVQNSKMSEASGIQQEDSYPKGSK 417
E+++ LK+ +D V +L+Q+ QN +M + ++D +
Sbjct: 939 DANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQN-RMKLMADNYEDDHFKSSHS 997
Query: 418 NIKN 421
N N
Sbjct: 998 NQTN 1001
Score = 37.4 bits (85), Expect = 0.029
Identities = 71/350 (20%), Positives = 148/350 (42%), Gaps = 79/350 (22%)
Query: 77 EDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYT 136
+D L++ R+ +K +EN + L +E KQ + ++ S Q+ T + L
Sbjct: 563 KDMLDVKERKVNVLQKKIENL--QEQLRDKE--KQMSSLKERVKSLQADTTNTDTALTTL 618
Query: 137 KRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKI 196
+ + ER + EQ+ + +REK+ E++D +K+ K ++K+
Sbjct: 619 EEALAEKERTIERLKEQRDRDEREKQ----------EEIDNYKKDL-------KDLKEKV 661
Query: 197 KHLEEKLKEEEHQRKLFQDKASEL-QTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKR 255
L+ L E+E ++ AS L +GL+ S + L+ + E+KK +C+K
Sbjct: 662 SLLQGDLSEKEASLLDLKEHASSLASSGLKKD----SRLKTLEIALEQKKE----ECLKM 713
Query: 256 RPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEK 315
L K +A P S++
Sbjct: 714 ESQ-------------------------------------LKKAHEAALEARASPEMSDR 736
Query: 316 SISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKG 375
+L + +DE + E LL+ +KE E+ +D + ++ L ++++ +
Sbjct: 737 ----IQHLEREITRYKDESSKAQAEVDRLLEILKEVENEK--NDKDKKIAELERQVKDQN 790
Query: 376 EQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRK 425
++++ L KH++ V +K ++++M E + ++ED+ S+ +++S RK
Sbjct: 791 KKVANL-KHKEQV----EKKKSAQMLEEAR-RREDNLNDSSQQLQDSLRK 834
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 58.2 bits (139), Expect = 2e-08
Identities = 84/424 (19%), Positives = 185/424 (43%), Gaps = 77/424 (18%)
Query: 59 LKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQ 118
+ +L+E++ L+ + T + L L A+ ++ +E +R+ +E ++ +
Sbjct: 566 MSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKD 625
Query: 119 LSSAQSRCTLLEKQLEYTKRMVLNVEREKNMI----LEQQAQLQ------REKEQDQMKL 168
L + + +LL+ L + +L+++ + + L++ ++L+ +K+++ +K+
Sbjct: 626 LKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKM 685
Query: 169 YAKLEK-----------------LDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRK 211
++L+K + LE+E R A+ ++ L E LKE E+++
Sbjct: 686 ESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKN 745
Query: 212 LFQDKASELQTGLEISKIIMSSVSNLKHSK--EKKKSSKKTKCIKRRPPWQICSKFGALP 269
K +EL+ ++ V+NLKH + EKKKS++ + +RR
Sbjct: 746 DKDKKIAELERQVKDQN---KKVANLKHKEQVEKKKSAQMLEEARRRE-----------D 791
Query: 270 FVAEKMRQHRDPHILQKPFNVTE-TRCLPKPSRTTSWCKAIPPDSEKSISICD-NLSELL 327
+ + +Q +D + +K + E L + + T+ + + E + + + + ELL
Sbjct: 792 NLNDSSQQLQD-SLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELL 850
Query: 328 MAMQ---DELDQMSMEHQELLKQMKETESH----------SVCDDIECELECLLKKMEIK 374
MAM+ EL+ M + + + E E+H + + +E + E LL + K
Sbjct: 851 MAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEK 910
Query: 375 G----------------EQISKLKKHQDS-VCKLQQKVQNSKMSEASGIQQEDSYPKGSK 417
E+++ LK+ +D V +L+Q+ QN +M + ++D +
Sbjct: 911 DANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQN-RMKLMADNYEDDHFKSSHS 969
Query: 418 NIKN 421
N N
Sbjct: 970 NQTN 973
Score = 37.4 bits (85), Expect = 0.029
Identities = 71/350 (20%), Positives = 148/350 (42%), Gaps = 79/350 (22%)
Query: 77 EDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYT 136
+D L++ R+ +K +EN + L +E KQ + ++ S Q+ T + L
Sbjct: 535 KDMLDVKERKVNVLQKKIENL--QEQLRDKE--KQMSSLKERVKSLQADTTNTDTALTTL 590
Query: 137 KRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKI 196
+ + ER + EQ+ + +REK+ E++D +K+ K ++K+
Sbjct: 591 EEALAEKERTIERLKEQRDRDEREKQ----------EEIDNYKKDL-------KDLKEKV 633
Query: 197 KHLEEKLKEEEHQRKLFQDKASEL-QTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKR 255
L+ L E+E ++ AS L +GL+ S + L+ + E+KK +C+K
Sbjct: 634 SLLQGDLSEKEASLLDLKEHASSLASSGLKKD----SRLKTLEIALEQKKE----ECLKM 685
Query: 256 RPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEK 315
L K +A P S++
Sbjct: 686 ESQ-------------------------------------LKKAHEAALEARASPEMSDR 708
Query: 316 SISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKG 375
+L + +DE + E LL+ +KE E+ +D + ++ L ++++ +
Sbjct: 709 ----IQHLEREITRYKDESSKAQAEVDRLLEILKEVENEK--NDKDKKIAELERQVKDQN 762
Query: 376 EQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRK 425
++++ L KH++ V +K ++++M E + ++ED+ S+ +++S RK
Sbjct: 763 KKVANL-KHKEQV----EKKKSAQMLEEAR-RREDNLNDSSQQLQDSLRK 806
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 58.2 bits (139), Expect = 2e-08
Identities = 80/410 (19%), Positives = 178/410 (43%), Gaps = 49/410 (11%)
Query: 35 HPANLEVTSPKILH-SPNSQALILALKTLQ----------EKIHRLELERTQAEDNLNIL 83
H N E+TS ++L +Q+L ++ L+ KI ++E E + + IL
Sbjct: 452 HEVN-ELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEIL 510
Query: 84 SREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEY-------- 135
E Q K++L+N N +E + +K I +++ + +LE++ E+
Sbjct: 511 ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSL 570
Query: 136 -------TKRMVLNVEREKNMILE-------QQAQLQREKEQDQMKL---YAKLEKLDVL 178
+ V ++E+E ++ E + ++++ EK Q + +L K E+ + L
Sbjct: 571 RQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEEL 630
Query: 179 EKECFRLTTTQKTAEDKIKHLE---EKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVS 235
E E L + + KI +L+ EK++ E + + + +L+ L+ K + +
Sbjct: 631 ENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLE 690
Query: 236 NLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRC 295
+L+ KE + ++ ++R C+ E + L+K + +
Sbjct: 691 SLE--KENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA-S 747
Query: 296 LPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHS 355
K R + + ++++ +N ++ + ++ EL + ME+Q L K ++E + S
Sbjct: 748 FKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISS 807
Query: 356 VCDDIECELECLLKKMEIKGEQISKLKKH---QDSVCKLQQKVQNSKMSE 402
+ +LE K +E + Q+ K KK ++ + Q +++++ + E
Sbjct: 808 KRLE---QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEE 854
Score = 48.1 bits (113), Expect = 2e-05
Identities = 86/410 (20%), Positives = 164/410 (40%), Gaps = 72/410 (17%)
Query: 62 LQEKIHRLELERTQ--------AEDNLNI-------------LSREAAQY---------- 90
L+ K+H +E+ER E+N+ + L E Q
Sbjct: 387 LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAP 446
Query: 91 KKALENETNE--------RNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLN 142
+K+L +E NE + +Q L K +++ + S + + + K + +R+
Sbjct: 447 QKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKK 506
Query: 143 VEREKNMILEQQAQLQ--REKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLE 200
VE +N I++++ LQ + +D MK A+LEK + T ++ +E +IK LE
Sbjct: 507 VEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK---------TIETLRENSERQIKILE 557
Query: 201 EKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKC-IKRRPPW 259
+ E EH + Q E + + + H K+ SSK +K ++R
Sbjct: 558 Q---ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIK 614
Query: 260 QICSKFGALPFVAEKMRQ-----HRDPHILQKPFNVTETRC--LPKPSRTTSWCKAIPPD 312
+ + AE++ ++ +LQK + C + + S +
Sbjct: 615 KELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRK 674
Query: 313 SEKSISICDNLSELLMAMQDELDQMSMEHQELLK--------QMKETESHSVCDDIECEL 364
+K++ NL+ L +++ E Q+ E+ EL + MK + ++E E
Sbjct: 675 LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK 734
Query: 365 ECLLKKMEIKGEQISKLKKHQDSVCKL---QQKVQNSKMSEASGIQQEDS 411
E L K +E+ K ++ + S L Q++Q + + IQQ +S
Sbjct: 735 EQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784
Score = 42.4 bits (98), Expect = 9e-04
Identities = 67/368 (18%), Positives = 160/368 (43%), Gaps = 40/368 (10%)
Query: 71 LERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLE 130
+E ++ D L+ L ++ + + +R + Q L S++L+ A+++ L
Sbjct: 212 IELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHL-------SVELADAKAKIRRLR 264
Query: 131 KQLEYTKRMVLNVEREKNMILEQQAQLQREKE---QDQMKLYAKLEKLDVLEKECFRLTT 187
++LE +L+ ++E + + +LQ+E D ++LD L ++ R+
Sbjct: 265 QELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV-- 322
Query: 188 TQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSS 247
DK++ + KE H + ++ + EL+ E +++++ + + L+ E ++
Sbjct: 323 ------DKLESEVSRYKERLHDIEFYKARVEELK---EDNQVLLETKTMLEDQLEGTRAR 373
Query: 248 KKTKCIKRRPPWQICSKFGALPF--------VAEKMRQHRDPHILQKPFNVTETRCLPKP 299
+ Q+ +K + + E M ++ + QK ++ E+ L
Sbjct: 374 SDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ-SMDESLHLGWE 432
Query: 300 SRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDD 359
S + +KS+ E+ L ++ ME+Q L K ++E + D
Sbjct: 433 LEQISRTSELSEAPQKSLG-----HEVNELTSSRLLKLEMENQSLTKTVEEL--RTTVDS 485
Query: 360 IECELECLLKKMEIKGEQIS-KLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKN 418
+E +L KME + +++S K++ ++ + + +Q +QN + ++++ K +
Sbjct: 486 VEGNASKIL-KMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544
Query: 419 IK-NSPRK 425
++ NS R+
Sbjct: 545 LRENSERQ 552
Score = 38.9 bits (89), Expect = 0.010
Identities = 68/319 (21%), Positives = 140/319 (43%), Gaps = 39/319 (12%)
Query: 62 LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISI--QL 119
L+ K +E+ER +N + + + A + + ET NL Q L Q++ +S+ Q
Sbjct: 1042 LKVKDRLIEVER----NNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQN 1097
Query: 120 SSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKE------QDQMKLYAKL- 172
++ Q++ L+ + ++ + +L QQ+ L+ E E +D LY L
Sbjct: 1098 TTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLI 1157
Query: 173 ---EKLDVLEK----ECFRLTTTQKTAEDKIKHLEEKLKE-EEHQRKLFQDKAS----EL 220
EKL++L + E L + T + K+LE + ++ E+ +L + K E
Sbjct: 1158 KDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEK 1217
Query: 221 QTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRD 280
+E K+++ + ++ + E KK + + Q+ + L H++
Sbjct: 1218 MLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYS-QLLKETEVL------QTDHKN 1270
Query: 281 PHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDE----LDQ 336
L + +TR + S+ + + S K + C+ LS+L +++E LDQ
Sbjct: 1271 LKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQ 1330
Query: 337 ---MSMEHQELLKQMKETE 352
+ ++++ LL+Q E++
Sbjct: 1331 IQTLMLQNRTLLEQNMESK 1349
Score = 38.5 bits (88), Expect = 0.013
Identities = 47/205 (22%), Positives = 83/205 (40%), Gaps = 18/205 (8%)
Query: 46 ILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAH 105
+L + N + + K L + RL +Q +L + K L N E+
Sbjct: 1227 LLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE 1286
Query: 106 QELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQ 165
E K K+ Q T L Q E ++ N+E E +L+ Q+Q Q++
Sbjct: 1287 AEFSKLKE----QYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLD---QIQTLMLQNR 1339
Query: 166 MKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHL---EEKLKEEEHQRKLFQDKASELQT 222
L +E D+ E Q+ DK+ L +EKL+E+ + F D + +
Sbjct: 1340 TLLEQNMESKDLFHVE-------QRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRR 1392
Query: 223 GLEISKIIMSSVSNLKH-SKEKKKS 246
G I+ + + + K ++E++KS
Sbjct: 1393 GNWITLKMRKLIKSKKDINRERQKS 1417
Score = 35.0 bits (79), Expect = 0.14
Identities = 40/184 (21%), Positives = 84/184 (45%), Gaps = 25/184 (13%)
Query: 57 LALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKA-----------LENETNERNLAH 105
+ + LQ + LE E+ Q + L +L A +KK +EN+ ++ L +
Sbjct: 718 MKMAQLQLENKELESEKEQLKKGLELLK---ASFKKTERLEVSYQGLDIENQRLQKTLEN 774
Query: 106 -----QELIKQKKDISIQLSSAQSRCTLLE---KQLEYTKRMVLNVEREKNMILEQQAQL 157
Q+L + +D+ ++ + Q L+ K+LE ++ ++E+E + + + + QL
Sbjct: 775 SNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQL 834
Query: 158 QREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEE---KLKEEEHQRKLFQ 214
++E ++ + + K L+ + L KT +I +E +LKE E + K
Sbjct: 835 EKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELV 894
Query: 215 DKAS 218
+A+
Sbjct: 895 KRAT 898
Score = 35.0 bits (79), Expect = 0.14
Identities = 42/203 (20%), Positives = 90/203 (44%), Gaps = 17/203 (8%)
Query: 53 QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQ---YKKALENETNE---RNLAHQ 106
++LI TL+ LE+E ED N L ++ Q +K L+ E + N H+
Sbjct: 1175 ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHE 1234
Query: 107 ELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREK-EQDQ 165
+ + K + + + L K+ E VL + + L ++L++ + E +
Sbjct: 1235 TVAAEYKKLCGENDRLNHTYSQLLKETE-----VLQTDHKNLKSLLNNSKLEQTRLEAEF 1289
Query: 166 MKLYAKLEKLDV----LEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQ 221
KL + ++LD+ L +C L+ + E++ +HL ++++ Q + ++ E +
Sbjct: 1290 SKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESK 1349
Query: 222 TGLEI-SKIIMSSVSNLKHSKEK 243
+ + + ++ L+ KEK
Sbjct: 1350 DLFHVEQRQYIDKLNELRRQKEK 1372
Score = 32.0 bits (71), Expect = 1.2
Identities = 80/397 (20%), Positives = 161/397 (40%), Gaps = 57/397 (14%)
Query: 45 KILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLA 104
K+L S L +L+ +EKI LE ++ + L +E KK
Sbjct: 955 KLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK------------ 1002
Query: 105 HQELIKQKKDISIQLSSA---QSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREK 161
+ E +KQ++D + S+ E++ + T R +L V+ + A LQ EK
Sbjct: 1003 NYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1062
Query: 162 EQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQ 221
+ + +L + + L+ + L + +++ L+ + + + + +++ L
Sbjct: 1063 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1122
Query: 222 TGLEISKIIMSSVSNLKHS--KEKK----------KSSKKTKCIKRRPPWQ---ICSKFG 266
I SS+ N S KE++ K +K + + R + + SK G
Sbjct: 1123 NQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHG 1182
Query: 267 ALPFVAEKMR-QHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSE 325
L + + +HRD L+ +N + L + + K + + EK + +N +
Sbjct: 1183 TLKSAHKNLEVEHRD---LEDRYN----QLLKQKGQLEDLEKMLKVEQEK--MLLENKNH 1233
Query: 326 LLMAMQ-----DELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQI-- 378
+A + E D+++ + +LL KETE V L+ LL +++ ++
Sbjct: 1234 ETVAAEYKKLCGENDRLNHTYSQLL---KETE---VLQTDHKNLKSLLNNSKLEQTRLEA 1287
Query: 379 --SKLKKHQDSVCKLQQKVQN--SKMSEASGIQQEDS 411
SKLK+ + K+ N +S+ G +E++
Sbjct: 1288 EFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEEN 1324
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 58.2 bits (139), Expect = 2e-08
Identities = 80/410 (19%), Positives = 178/410 (43%), Gaps = 49/410 (11%)
Query: 35 HPANLEVTSPKILH-SPNSQALILALKTLQ----------EKIHRLELERTQAEDNLNIL 83
H N E+TS ++L +Q+L ++ L+ KI ++E E + + IL
Sbjct: 452 HEVN-ELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEIL 510
Query: 84 SREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEY-------- 135
E Q K++L+N N +E + +K I +++ + +LE++ E+
Sbjct: 511 ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSL 570
Query: 136 -------TKRMVLNVEREKNMILE-------QQAQLQREKEQDQMKL---YAKLEKLDVL 178
+ V ++E+E ++ E + ++++ EK Q + +L K E+ + L
Sbjct: 571 RQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEEL 630
Query: 179 EKECFRLTTTQKTAEDKIKHLE---EKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVS 235
E E L + + KI +L+ EK++ E + + + +L+ L+ K + +
Sbjct: 631 ENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLE 690
Query: 236 NLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRC 295
+L+ KE + ++ ++R C+ E + L+K + +
Sbjct: 691 SLE--KENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA-S 747
Query: 296 LPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHS 355
K R + + ++++ +N ++ + ++ EL + ME+Q L K ++E + S
Sbjct: 748 FKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISS 807
Query: 356 VCDDIECELECLLKKMEIKGEQISKLKKH---QDSVCKLQQKVQNSKMSE 402
+ +LE K +E + Q+ K KK ++ + Q +++++ + E
Sbjct: 808 KRLE---QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEE 854
Score = 48.1 bits (113), Expect = 2e-05
Identities = 86/410 (20%), Positives = 164/410 (40%), Gaps = 72/410 (17%)
Query: 62 LQEKIHRLELERTQ--------AEDNLNI-------------LSREAAQY---------- 90
L+ K+H +E+ER E+N+ + L E Q
Sbjct: 387 LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAP 446
Query: 91 KKALENETNE--------RNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLN 142
+K+L +E NE + +Q L K +++ + S + + + K + +R+
Sbjct: 447 QKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKK 506
Query: 143 VEREKNMILEQQAQLQ--REKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLE 200
VE +N I++++ LQ + +D MK A+LEK + T ++ +E +IK LE
Sbjct: 507 VEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK---------TIETLRENSERQIKILE 557
Query: 201 EKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKC-IKRRPPW 259
+ E EH + Q E + + + H K+ SSK +K ++R
Sbjct: 558 Q---ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIK 614
Query: 260 QICSKFGALPFVAEKMRQ-----HRDPHILQKPFNVTETRC--LPKPSRTTSWCKAIPPD 312
+ + AE++ ++ +LQK + C + + S +
Sbjct: 615 KELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRK 674
Query: 313 SEKSISICDNLSELLMAMQDELDQMSMEHQELLK--------QMKETESHSVCDDIECEL 364
+K++ NL+ L +++ E Q+ E+ EL + MK + ++E E
Sbjct: 675 LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK 734
Query: 365 ECLLKKMEIKGEQISKLKKHQDSVCKL---QQKVQNSKMSEASGIQQEDS 411
E L K +E+ K ++ + S L Q++Q + + IQQ +S
Sbjct: 735 EQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784
Score = 42.4 bits (98), Expect = 9e-04
Identities = 67/368 (18%), Positives = 160/368 (43%), Gaps = 40/368 (10%)
Query: 71 LERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLE 130
+E ++ D L+ L ++ + + +R + Q L S++L+ A+++ L
Sbjct: 212 IELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHL-------SVELADAKAKIRRLR 264
Query: 131 KQLEYTKRMVLNVEREKNMILEQQAQLQREKE---QDQMKLYAKLEKLDVLEKECFRLTT 187
++LE +L+ ++E + + +LQ+E D ++LD L ++ R+
Sbjct: 265 QELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV-- 322
Query: 188 TQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSS 247
DK++ + KE H + ++ + EL+ E +++++ + + L+ E ++
Sbjct: 323 ------DKLESEVSRYKERLHDIEFYKARVEELK---EDNQVLLETKTMLEDQLEGTRAR 373
Query: 248 KKTKCIKRRPPWQICSKFGALPF--------VAEKMRQHRDPHILQKPFNVTETRCLPKP 299
+ Q+ +K + + E M ++ + QK ++ E+ L
Sbjct: 374 SDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ-SMDESLHLGWE 432
Query: 300 SRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDD 359
S + +KS+ E+ L ++ ME+Q L K ++E + D
Sbjct: 433 LEQISRTSELSEAPQKSLG-----HEVNELTSSRLLKLEMENQSLTKTVEEL--RTTVDS 485
Query: 360 IECELECLLKKMEIKGEQIS-KLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKN 418
+E +L KME + +++S K++ ++ + + +Q +QN + ++++ K +
Sbjct: 486 VEGNASKIL-KMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544
Query: 419 IK-NSPRK 425
++ NS R+
Sbjct: 545 LRENSERQ 552
Score = 38.9 bits (89), Expect = 0.010
Identities = 68/319 (21%), Positives = 140/319 (43%), Gaps = 39/319 (12%)
Query: 62 LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISI--QL 119
L+ K +E+ER +N + + + A + + ET NL Q L Q++ +S+ Q
Sbjct: 1041 LKVKDRLIEVER----NNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQN 1096
Query: 120 SSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKE------QDQMKLYAKL- 172
++ Q++ L+ + ++ + +L QQ+ L+ E E +D LY L
Sbjct: 1097 TTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLI 1156
Query: 173 ---EKLDVLEK----ECFRLTTTQKTAEDKIKHLEEKLKE-EEHQRKLFQDKAS----EL 220
EKL++L + E L + T + K+LE + ++ E+ +L + K E
Sbjct: 1157 KDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEK 1216
Query: 221 QTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRD 280
+E K+++ + ++ + E KK + + Q+ + L H++
Sbjct: 1217 MLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYS-QLLKETEVL------QTDHKN 1269
Query: 281 PHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDE----LDQ 336
L + +TR + S+ + + S K + C+ LS+L +++E LDQ
Sbjct: 1270 LKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQ 1329
Query: 337 ---MSMEHQELLKQMKETE 352
+ ++++ LL+Q E++
Sbjct: 1330 IQTLMLQNRTLLEQNMESK 1348
Score = 38.5 bits (88), Expect = 0.013
Identities = 47/205 (22%), Positives = 83/205 (40%), Gaps = 18/205 (8%)
Query: 46 ILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAH 105
+L + N + + K L + RL +Q +L + K L N E+
Sbjct: 1226 LLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE 1285
Query: 106 QELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQ 165
E K K+ Q T L Q E ++ N+E E +L+ Q+Q Q++
Sbjct: 1286 AEFSKLKE----QYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLD---QIQTLMLQNR 1338
Query: 166 MKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHL---EEKLKEEEHQRKLFQDKASELQT 222
L +E D+ E Q+ DK+ L +EKL+E+ + F D + +
Sbjct: 1339 TLLEQNMESKDLFHVE-------QRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRR 1391
Query: 223 GLEISKIIMSSVSNLKH-SKEKKKS 246
G I+ + + + K ++E++KS
Sbjct: 1392 GNWITLKMRKLIKSKKDINRERQKS 1416
Score = 35.0 bits (79), Expect = 0.14
Identities = 40/184 (21%), Positives = 84/184 (45%), Gaps = 25/184 (13%)
Query: 57 LALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKA-----------LENETNERNLAH 105
+ + LQ + LE E+ Q + L +L A +KK +EN+ ++ L +
Sbjct: 718 MKMAQLQLENKELESEKEQLKKGLELLK---ASFKKTERLEVSYQGLDIENQRLQKTLEN 774
Query: 106 -----QELIKQKKDISIQLSSAQSRCTLLE---KQLEYTKRMVLNVEREKNMILEQQAQL 157
Q+L + +D+ ++ + Q L+ K+LE ++ ++E+E + + + + QL
Sbjct: 775 SNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQL 834
Query: 158 QREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEE---KLKEEEHQRKLFQ 214
++E ++ + + K L+ + L KT +I +E +LKE E + K
Sbjct: 835 EKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELV 894
Query: 215 DKAS 218
+A+
Sbjct: 895 KRAT 898
Score = 35.0 bits (79), Expect = 0.14
Identities = 42/203 (20%), Positives = 90/203 (44%), Gaps = 17/203 (8%)
Query: 53 QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQ---YKKALENETNE---RNLAHQ 106
++LI TL+ LE+E ED N L ++ Q +K L+ E + N H+
Sbjct: 1174 ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHE 1233
Query: 107 ELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREK-EQDQ 165
+ + K + + + L K+ E VL + + L ++L++ + E +
Sbjct: 1234 TVAAEYKKLCGENDRLNHTYSQLLKETE-----VLQTDHKNLKSLLNNSKLEQTRLEAEF 1288
Query: 166 MKLYAKLEKLDV----LEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQ 221
KL + ++LD+ L +C L+ + E++ +HL ++++ Q + ++ E +
Sbjct: 1289 SKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESK 1348
Query: 222 TGLEI-SKIIMSSVSNLKHSKEK 243
+ + + ++ L+ KEK
Sbjct: 1349 DLFHVEQRQYIDKLNELRRQKEK 1371
Score = 32.0 bits (71), Expect = 1.2
Identities = 80/397 (20%), Positives = 161/397 (40%), Gaps = 57/397 (14%)
Query: 45 KILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLA 104
K+L S L +L+ +EKI LE ++ + L +E KK
Sbjct: 954 KLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK------------ 1001
Query: 105 HQELIKQKKDISIQLSSA---QSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREK 161
+ E +KQ++D + S+ E++ + T R +L V+ + A LQ EK
Sbjct: 1002 NYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1061
Query: 162 EQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQ 221
+ + +L + + L+ + L + +++ L+ + + + + +++ L
Sbjct: 1062 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1121
Query: 222 TGLEISKIIMSSVSNLKHS--KEKK----------KSSKKTKCIKRRPPWQ---ICSKFG 266
I SS+ N S KE++ K +K + + R + + SK G
Sbjct: 1122 NQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHG 1181
Query: 267 ALPFVAEKMR-QHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSE 325
L + + +HRD L+ +N + L + + K + + EK + +N +
Sbjct: 1182 TLKSAHKNLEVEHRD---LEDRYN----QLLKQKGQLEDLEKMLKVEQEK--MLLENKNH 1232
Query: 326 LLMAMQ-----DELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQI-- 378
+A + E D+++ + +LL KETE V L+ LL +++ ++
Sbjct: 1233 ETVAAEYKKLCGENDRLNHTYSQLL---KETE---VLQTDHKNLKSLLNNSKLEQTRLEA 1286
Query: 379 --SKLKKHQDSVCKLQQKVQN--SKMSEASGIQQEDS 411
SKLK+ + K+ N +S+ G +E++
Sbjct: 1287 EFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEEN 1323
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 57.8 bits (138), Expect = 2e-08
Identities = 62/307 (20%), Positives = 131/307 (42%), Gaps = 40/307 (13%)
Query: 102 NLAHQELIKQKKDISIQLSSAQSRCTL--LEKQLEYTKRMVLNVEREKNMILEQQAQLQR 159
N+ H +K I L SA++ + ++++ + TK + E ++ + E+ L +
Sbjct: 824 NVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQ 883
Query: 160 EKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH-------QRKL 212
EK Q+++ A+ E L E+ C +L + E KIK + E+ ++EE +++
Sbjct: 884 EKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRK 943
Query: 213 FQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVA 272
+D+ SEL+ ++ ++ ++ V KH+ E K + + + L
Sbjct: 944 LEDECSELKKDIDDLELTLAKVEKEKHATENKVKN-------------LTEELSGLDETI 990
Query: 273 EKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQD 332
K+ + + K + L + + +K S+ S+L ++D
Sbjct: 991 AKLTREK------KALQEAHQQALDD----------LQAEEDKVNSLNKTKSKLEQQVED 1034
Query: 333 ELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQ 392
+ S+E ++ L+ E + D++ E +L K + +LKK C+LQ
Sbjct: 1035 L--ESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQ 1092
Query: 393 QKVQNSK 399
KV++ +
Sbjct: 1093 SKVEDEQ 1099
Score = 54.3 bits (129), Expect = 2e-07
Identities = 81/382 (21%), Positives = 166/382 (43%), Gaps = 51/382 (13%)
Query: 55 LILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKD 114
LI A L+ KI + ER + E+ +N E K+ LE+E +E KKD
Sbjct: 909 LIKAKFQLEAKIKEVT-ERAEDEEEINA---ELTAKKRKLEDECSEL----------KKD 954
Query: 115 IS-IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLE 173
I ++L+ A+ +EK+ T+ V N+ E + + E A+L REK+ Q L+
Sbjct: 955 IDDLELTLAK-----VEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALD 1009
Query: 174 KLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSS 233
L E + L T+ E +++ LE L++E+ R + +L+ L++++ +
Sbjct: 1010 DLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILD 1069
Query: 234 VSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTET 293
+ N K +++ K + + + + G K Q R + ++ T
Sbjct: 1070 LENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERAT 1129
Query: 294 RCLPKPSRTTSWCKAIPPDSEK----------SISICDNLSELLMAMQDELDQMSMEHQE 343
R + R + + + + SE+ I + + ++ +L++ +++H+
Sbjct: 1130 RAKTEKQR-SDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEA 1188
Query: 344 LLKQMKETESHSVC------DDIECELECLLK-----KMEIKG-----EQISKLKKHQDS 387
++ +++ + SV D+++ + L K K+EI E +SK K + +
Sbjct: 1189 MVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEK 1248
Query: 388 VCKLQQKVQNSKMSEASGIQQE 409
+C+ + ++SEA G +E
Sbjct: 1249 ICRTLE----DQLSEARGKNEE 1266
Score = 49.7 bits (117), Expect = 6e-06
Identities = 83/442 (18%), Positives = 175/442 (39%), Gaps = 24/442 (5%)
Query: 29 EPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAA 88
E +++ N E+T+ K L + L+ + ++E E+ E+ + L+ E +
Sbjct: 925 ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELS 984
Query: 89 QYKKALENETNERNL---AHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVER 145
+ + T E+ AHQ+ + + +++S + LE+Q+E + ++E+
Sbjct: 985 GLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLES---SLEQ 1041
Query: 146 EKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKE 205
EK + + L+R K + + L E + LE + +L K + + L+ K+++
Sbjct: 1042 EKKL----RVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVED 1097
Query: 206 EEHQRKLFQDKASELQTGLE--ISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICS 263
E+ FQ K ELQ +E +I + K K++ +++ + + R
Sbjct: 1098 EQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSER-----LE 1152
Query: 264 KFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNL 323
+ G + ++ + R+ L+ ++ E + K +E I DNL
Sbjct: 1153 EAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQI-DNL 1211
Query: 324 SELLMAMQDELDQMSMEHQELLKQMKETES-----HSVCDDIECELECLLKKMEIKGEQI 378
+ ++ E + +E +L M+ +C +E +L K E +
Sbjct: 1212 QRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSL 1271
Query: 379 SKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRKCLTDTNLFQKNSS 438
S+L Q S + + + ++ E I + S K + + K + KN+
Sbjct: 1272 SELTT-QKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNAL 1330
Query: 439 FHPIRVHNLQMKLRRDDIMWEQ 460
H ++ L R+ EQ
Sbjct: 1331 AHALQSSRHDCDLLREQYEEEQ 1352
Score = 43.5 bits (101), Expect = 4e-04
Identities = 75/371 (20%), Positives = 148/371 (39%), Gaps = 71/371 (19%)
Query: 62 LQEKIHRLELERTQAEDN----------LNILSREAAQYKKALENE----TNERNLAHQE 107
LQ H +L R Q E+ L+ + E AQ++ E + T E A ++
Sbjct: 1334 LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1393
Query: 108 LIKQKKDISIQLSSAQSRCTLLEKQLE----YTKRMVLNVEREKNM--ILEQQ------- 154
L ++ +D Q+ + ++C LEK + + ++++VER ++ L+++
Sbjct: 1394 LAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKV 1453
Query: 155 -AQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLF 213
A+ + + E+ Q +L A L++ L E F+L + A D+++ ++ + K E
Sbjct: 1454 LAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQ----- 1508
Query: 214 QDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAE 273
EI+ + N K E +KS K+ + K + AE
Sbjct: 1509 -----------EIADLTEQIAENGKTIHELEKSRKQIELEK--------ADIQLALEEAE 1549
Query: 274 KMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDE 333
+H + IL+ +T+ + + + I E+ + N + MQ
Sbjct: 1550 AALEHEEAKILRIQLELTQVK--------SEIDRKIAEKDEEIEQLKRNYQRTVETMQSA 1601
Query: 334 LDQMSMEHQELLKQMKETESHSVCDDIECEL--------ECLLKKMEIKGEQISKLKKHQ 385
LD E ++ K+ E ++IE +L E L ++G Q+ + H
Sbjct: 1602 LDAEVRSRNEAIRLKKKMEGD--LNEIEIQLSHANRQAAETLKHLRSVQG-QLKDTQLHL 1658
Query: 386 DSVCKLQQKVQ 396
D + Q+ ++
Sbjct: 1659 DDALRGQEDLK 1669
Score = 40.4 bits (93), Expect = 0.003
Identities = 42/203 (20%), Positives = 90/203 (44%), Gaps = 20/203 (9%)
Query: 53 QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETN---ERNLAHQELI 109
+A + ++L ++ +L+ +A D L + RE ++ + + T E EL
Sbjct: 1469 EASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELE 1528
Query: 110 KQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLY 169
K +K I ++ + Q E LE+ E+ IL Q +L + K + K+
Sbjct: 1529 KSRKQIELEKADIQLALEEAEAALEH----------EEAKILRIQLELTQVKSEIDRKIA 1578
Query: 170 AKLEKLDVLEKECFRLTTTQKTAED-KIKHLEEKLKEEEHQRKLFQDKASELQTGLEISK 228
K E+++ L++ R T ++A D +++ E ++ +K + +E++ +++S
Sbjct: 1579 EKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIR----LKKKMEGDLNEIE--IQLSH 1632
Query: 229 IIMSSVSNLKHSKEKKKSSKKTK 251
+ LKH + + K T+
Sbjct: 1633 ANRQAAETLKHLRSVQGQLKDTQ 1655
Score = 39.7 bits (91), Expect = 0.006
Identities = 68/344 (19%), Positives = 142/344 (41%), Gaps = 48/344 (13%)
Query: 71 LERTQAEDNLNILSR-EAAQYKKALENETNE-------------RNLAHQELIK-QKKDI 115
+E Q+ + + SR EA + KK +E + NE L H ++ Q KD
Sbjct: 1595 VETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDT 1654
Query: 116 SIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKL 175
+ L A L++QL +R ++ E + Q +R ++ + +L E++
Sbjct: 1655 QLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERV 1714
Query: 176 DVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQT-GLEISKIIMSSV 234
+L + L T+K E + L+ ++++ + ++KA + T +++ +
Sbjct: 1715 QLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQ 1774
Query: 235 SNLKHSKEKKKSSKKT-KCIKRR--PPWQICSKFGALPFVAEKMRQHRDPHILQKPF--- 288
H + KK+ ++T K ++ R Q+ K G +K Q + I + F
Sbjct: 1775 DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGG------KKQIQKLETRIRELEFELE 1828
Query: 289 -----NVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQE 343
N + L K R K + SE+ + ++ +QD +D++ ++ +
Sbjct: 1829 GEQKKNTESVKGLRKYERRV---KELTYQSEED-------RKNVLRLQDLVDKLQVKVKS 1878
Query: 344 LLKQMKETESHSVCD-----DIECELECLLKKMEIKGEQISKLK 382
+Q +E + + + ELE ++ +I Q++KL+
Sbjct: 1879 YKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLR 1922
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 57.0 bits (136), Expect = 4e-08
Identities = 64/345 (18%), Positives = 151/345 (43%), Gaps = 33/345 (9%)
Query: 57 LALKTLQEKIHR--LELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKD 114
L +K L+ K+ R L L + Q + + L +E L+ + E L ++ +Q++
Sbjct: 230 LNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEK 289
Query: 115 ISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEK 174
+ Q Q R +++Q E + + R++ M+ E++ +++R++E ++ K EK
Sbjct: 290 MWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM----MWEKEEK 345
Query: 175 LDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSV 234
+ LE++ ++KI+ EEK +EEE R+ + + E + + KI
Sbjct: 346 IRELEEKMHE--------QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI-REQE 396
Query: 235 SNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETR 294
++ +E + ++ + W+ + + EKMR+ ++ E +
Sbjct: 397 EKIREQEEMMQEQEEKMGEQEEKMWE---QEEEMQEQEEKMRRQ------EEKIREQEKK 447
Query: 295 CLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESH 354
+ + + + EK + E MQ++ ++M + +++ +Q K+
Sbjct: 448 IREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQ 507
Query: 355 SVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSK 399
E + ++ E+ EQ K+ + ++ +C+ ++K+Q +
Sbjct: 508 E---------EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE 543
Score = 47.8 bits (112), Expect = 2e-05
Identities = 67/392 (17%), Positives = 162/392 (41%), Gaps = 56/392 (14%)
Query: 58 ALKTLQEKIHRLELERTQAEDNL------NILSREAAQYKKA--------LENETNERNL 103
A+ T ++K R E T+ D L N ++ E + K A +E+E +E L
Sbjct: 171 AVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQL 230
Query: 104 AHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQ 163
+EL ++ + + L Q L+ + ++ + + +V + +E+ R +Q
Sbjct: 231 NVKELKRKLERAKLLLPQQQ-----LQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQ 285
Query: 164 DQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTG 223
+ K++ + EK+ E++ + E+K++ EE + E+E + + ++ E +
Sbjct: 286 QEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 345
Query: 224 LEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHI 283
+ + M ++ +EK++ +K + ++ RQ ++ +
Sbjct: 346 IRELEEKMHEQEKIREQEEKRQEEEKIR--------------------EQEKRQEQEAKM 385
Query: 284 LQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQE 343
++ + E + + + + EK + + E MQ++ ++M + ++
Sbjct: 386 WRQEEKIRE-----QEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEK 440
Query: 344 LLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEA 403
+ +Q K+ I + E + ++ E+ EQ K+ + + +C+ + K+Q E
Sbjct: 441 IREQEKK---------IREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQE---QEE 488
Query: 404 SGIQQEDSYPKGSKNIKNSPRKCLTDTNLFQK 435
+QE+ + K I+ K + Q+
Sbjct: 489 KMRRQEEKIREQEKKIREQEEKIREQEEMMQE 520
Score = 37.7 bits (86), Expect = 0.022
Identities = 52/299 (17%), Positives = 124/299 (41%), Gaps = 29/299 (9%)
Query: 63 QEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSA 122
+EKI E E+ Q ++ E + ++ + E E+ +E++ +K++ +L
Sbjct: 294 EEKIQERE-EKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE-- 350
Query: 123 QSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKEC 182
EK E K E+E+ E++ + Q ++++ + K++ + EK+ E++
Sbjct: 351 -------EKMHEQEKIR----EQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 399
Query: 183 FRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGL-EISKIIMSSVSNLKHSK 241
+ E+K+ EEK+ E+E + + ++K + + E K I ++ +
Sbjct: 400 REQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE 459
Query: 242 EKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMR------QHRDPHILQKPFNVTETRC 295
E + ++ ++C + + EKMR + ++ I ++ + E
Sbjct: 460 EMMQEQEEK---MGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 516
Query: 296 LPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESH 354
+ + W EK + + E M+ + ++M + L +Q ++ + H
Sbjct: 517 MMQEQEEKMW-----EQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQEH 570
Score = 29.6 bits (65), Expect = 6.0
Identities = 29/140 (20%), Positives = 59/140 (42%), Gaps = 16/140 (11%)
Query: 321 DNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISK 380
+ L E +Q++L + E E+ +KE + + LL + +++ E
Sbjct: 205 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLE------RAKLLLPQQQLQAEADHL 258
Query: 381 LKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRKCLTDTNLFQKNSSFH 440
K+ Q KLQ +V+ +++ QQE+ + + I+ K
Sbjct: 259 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKI---------QEQEE 309
Query: 441 PIRVHNLQMKLRRDDIMWEQ 460
IR +M+ R++++MWE+
Sbjct: 310 KIREQEEKMR-RQEEMMWEK 328
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 57.0 bits (136), Expect = 4e-08
Identities = 57/291 (19%), Positives = 123/291 (42%), Gaps = 38/291 (13%)
Query: 117 IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLD 176
++ + A+ +++ E TK + E + + E+ L +EK Q+++ ++ E L
Sbjct: 844 LKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLM 903
Query: 177 VLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH-------QRKLFQDKASELQTGLEISKI 229
E+ C L ++ E K+K L E+L+EEE +++ +DK S L+ ++ ++
Sbjct: 904 DAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLEL 963
Query: 230 IMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFN 289
++ V KH+ E K + + + AL K+ +
Sbjct: 964 TLTKVEKEKHATENKVKN-------------LSEEMTALEENISKLTK------------ 998
Query: 290 VTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMK 349
E + L + + T + D + ++ L D+L+ S+E ++ L+
Sbjct: 999 --EKKSLQEAHQQTLDDLQVEEDKVNGLI---KINAKLEQQTDDLEG-SLEQEKKLRADL 1052
Query: 350 ETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKM 400
E + D++ E ++ K + KLKK + + +LQ K+ + ++
Sbjct: 1053 ERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQV 1103
Score = 55.1 bits (131), Expect = 1e-07
Identities = 73/342 (21%), Positives = 150/342 (43%), Gaps = 28/342 (8%)
Query: 63 QEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSA 122
+ K+ L E T E+N++ L++E KK+L+ AHQ+ + D+ ++
Sbjct: 976 ENKVKNLSEEMTALEENISKLTKE----KKSLQE-------AHQQTLD---DLQVEEDKV 1021
Query: 123 QSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKEC 182
+ K + T + ++E+EK + +A L+R K + + L E + LE +
Sbjct: 1022 NGLIKINAKLEQQTDDLEGSLEQEKKL----RADLERAKRKLEGDLKMSQESIMDLENDK 1077
Query: 183 FRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKE 242
++ K E ++ L+ K+ +E+ FQ K ELQ +E + + + L+ E
Sbjct: 1078 QQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIE 1137
Query: 243 KKKS--SKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPS 300
K++S +++ + I R + GA E M + R+ + ++ E + +
Sbjct: 1138 KQRSDLARELEEISER----LEEASGATSAQIE-MNKKREAEFQKMRRDLEEATLQHEAT 1192
Query: 301 RTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDI 360
T K +E I DNL + ++ E ++ ME ++ ++ +
Sbjct: 1193 AATLRKKQADSVAELGEQI-DNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIER 1251
Query: 361 ECE-LECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMS 401
C +E +++ K EQ ++L H ++ K + + QN ++S
Sbjct: 1252 TCRTVEDQFSEIKAKDEQQTQL-IHDLNMQKARLQTQNGELS 1292
Score = 49.3 bits (116), Expect = 7e-06
Identities = 68/378 (17%), Positives = 144/378 (38%), Gaps = 34/378 (8%)
Query: 92 KALENETNERNLAHQELIKQKKDISIQLSSAQS-------RCTLLEKQLEYTKRMVLNVE 144
K L E + EL+ +K+++ + SS + T +EK+ T+ V N+
Sbjct: 924 KELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLS 983
Query: 145 REKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLK 204
E + E ++L +EK+ Q L+ L V E + L E + LE L+
Sbjct: 984 EEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLE 1043
Query: 205 EEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRP------- 257
+E+ R + +L+ L++S+ + + N K E+K K+ + + +
Sbjct: 1044 QEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQV 1103
Query: 258 -PWQICSKFGALPFVAEKMRQHRD-PHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEK 315
Q K L E++ + + H L+ + + + + +
Sbjct: 1104 HSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSA 1163
Query: 316 SISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKG 375
I + M+ +L++ +++H+ +++ ++ SV + G
Sbjct: 1164 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAE---------------LG 1208
Query: 376 EQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRKCLTDTNLFQK 435
EQI L++ + KL+++ KM ++ K NI+ + R + +
Sbjct: 1209 EQIDNLQRVKQ---KLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKA 1265
Query: 436 NSSFHPIRVHNLQMKLRR 453
+H+L M+ R
Sbjct: 1266 KDEQQTQLIHDLNMQKAR 1283
Score = 45.8 bits (107), Expect = 8e-05
Identities = 71/394 (18%), Positives = 163/394 (41%), Gaps = 60/394 (15%)
Query: 62 LQEKIHRLELERTQAEDN----------LNILSREAAQYKKALENE----TNERNLAHQE 107
LQ H +L R Q E+ L+ + E AQ++ E + T E A ++
Sbjct: 1337 LQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1396
Query: 108 LIKQKKDISIQLSSAQSRCTLLEK--------------QLEYTKRMVLNVEREKNMILEQ 153
L ++ ++ +A S+C LEK LE + +++++ +
Sbjct: 1397 LAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKV 1456
Query: 154 QAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLF 213
A+ +++ ++ Q +L A ++ L E F++ + D+++ L + K + +
Sbjct: 1457 LAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDL 1516
Query: 214 QDKASE----LQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALP 269
++ +E LQ + K++ S+L+ + E+ + S + + SK +
Sbjct: 1517 TEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEE----------SKILRVQ 1566
Query: 270 FVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMA 329
+++ D +++K + + L + S+ + +A+ + I ++ L
Sbjct: 1567 LELSQVKSELDRKVIEKDEEIEQ---LKRNSQRAA--EALQSVLDAEIRSRNDALRLKKK 1621
Query: 330 MQDELDQMSMEHQELLKQMKETESH-----SVCDDIECELECLLKKMEIKGEQIS----- 379
M+ +L++M ++ +QM ET+ H D + L+ L+ E EQ++
Sbjct: 1622 MEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERR 1681
Query: 380 ---KLKKHQDSVCKLQQKVQNSKMSEASGIQQED 410
L++ ++ L+Q + ++SE + D
Sbjct: 1682 NGLLLEELEEMKVALEQTERTRRLSEQELLDASD 1715
Score = 39.3 bits (90), Expect = 0.008
Identities = 64/356 (17%), Positives = 140/356 (39%), Gaps = 42/356 (11%)
Query: 72 ERTQAEDNLNI---------------------LSREAAQYKKALENETNERNLAHQELIK 110
++TQ +LN+ L + + K+AL + E +E K
Sbjct: 1269 QQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETK 1328
Query: 111 QKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYA 170
K ++ L S++ C LL +Q E + ++R + + AQ + + E D
Sbjct: 1329 AKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETD------ 1382
Query: 171 KLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKII 230
+++ + LE+ +L + AE+ + K E ++ Q + +L LE S
Sbjct: 1383 AIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTA 1442
Query: 231 MSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFG-ALPFVAEKMRQHRDPHILQKPFN 289
+++ + + +K + K K + + + K +L KMR + + Q
Sbjct: 1443 CATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETL 1502
Query: 290 VTETRCLPK-----PSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQEL 344
E + L + + K + + + S+L +A+++ + E ++
Sbjct: 1503 RRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKI 1562
Query: 345 LKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKM 400
L+ E ++ EL+ +K+ K E+I +LK++ + Q V ++++
Sbjct: 1563 LRVQLE------LSQVKSELD---RKVIEKDEEIEQLKRNSQRAAEALQSVLDAEI 1609
Score = 35.0 bits (79), Expect = 0.14
Identities = 73/393 (18%), Positives = 162/393 (41%), Gaps = 45/393 (11%)
Query: 60 KTLQEKIHRL--ELERT-----QAEDNLNILSREAAQYKKALENETNERNLAHQE--LIK 110
K LQE+I L ++ T +AE ++ +E + + ALE E +L H+E +++
Sbjct: 1507 KNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEV--EGSLEHEESKILR 1564
Query: 111 QKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYA 170
+ ++S S + ++++E KR +L+ + + + + + + K+
Sbjct: 1565 VQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEG 1624
Query: 171 KLEKLDV--------LEKECFRLTTTQKTAEDKIKHLEEKLKEEE---HQRKLFQDKASE 219
L ++++ + + L T Q +D HL++ L+ E Q + + +
Sbjct: 1625 DLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGL 1684
Query: 220 LQTGLEISKIIMSSVSNLKHSKEKK--KSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQ 277
L LE K+ + + E++ +S + + + + I +K +A+ Q
Sbjct: 1685 LLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQ--CQ 1742
Query: 278 HRDPHILQKPFNVTE--TRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQ---D 332
+ +Q+ N E + + + K S + NL + + +Q D
Sbjct: 1743 AEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLD 1802
Query: 333 ELDQMSMEHQELLKQMKETESHSVCDDIECE-------------LECLLKKMEIKGEQIS 379
E +Q++++ + Q E + ++++ E E +K+M + E+
Sbjct: 1803 EAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDH 1862
Query: 380 K-LKKHQDSVCKLQQKVQNSKMSEASGIQQEDS 411
K + + QD V KLQ KV++ K +Q ++
Sbjct: 1863 KNILRLQDLVDKLQAKVKSYKRQAEEAEEQANT 1895
Score = 33.1 bits (74), Expect = 0.54
Identities = 35/148 (23%), Positives = 67/148 (45%), Gaps = 12/148 (8%)
Query: 38 NLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENE 97
NLE T + H + +A LALK +++I +LE + E+ L++ + A+ K
Sbjct: 1789 NLEQTVKDLQHRLD-EAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHK- 1846
Query: 98 TNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQL 157
ER + +E+ Q ++ + Q L+ +++ KR E + N L + ++
Sbjct: 1847 -YERKV--KEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRV 1903
Query: 158 QREKEQDQMKLYAKLEKLDVLEKECFRL 185
Q E E+ E+ D+ E + +L
Sbjct: 1904 QHELEE-------AAERADIAESQVNKL 1924
>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
b [Homo sapiens]
Length = 882
Score = 56.2 bits (134), Expect = 6e-08
Identities = 91/416 (21%), Positives = 180/416 (43%), Gaps = 73/416 (17%)
Query: 32 QNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYK 91
Q C LE+T + + +A K LQ ++ +L+ +A+ + +++AAQ K
Sbjct: 289 QQCMATELEMTVKEAKQDKSKEA---ECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCK 345
Query: 92 K-----ALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVERE 146
+ E +R L L+ ++K +IQ L+++L+ +++E
Sbjct: 346 EEAALAGCHLEDTQRKLQKGLLLDKQKADTIQE---------LQRELQM-------LQKE 389
Query: 147 KNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAE-------DKIKH- 198
+M ++Q ++ E+ ++L L KL+ +KE +L T + D+IKH
Sbjct: 390 SSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQ 449
Query: 199 ------LEEKLKEE-EHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTK 251
++ KL+E+ + KL +DK +L+ E K++ + L+ +KK + K
Sbjct: 450 HREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKEN 509
Query: 252 CIK-------RRPPWQICS--------KFGALPFVAEKMRQHRDPHILQKPFNVTETRCL 296
K R Q CS K+ V + + + LQK ++ L
Sbjct: 510 SRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKE---IALQKESLMSLQAQL 566
Query: 297 PKP-------SRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMK 349
K +TT +A S KS + D+L++ L ++L+ ++ E + L + +
Sbjct: 567 DKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQAL----EKLNHVTSETKSLQQSLT 622
Query: 350 ETESHSVCDDIECELECLLKKMEIKGEQISKLKK-HQDSVCKLQQKVQNSKMSEAS 404
+T+ +E E+ ++M+ ++ KL+ HQ+S +L+ + K+ E S
Sbjct: 623 QTQEKKA--QLEEEIIAYEERMKKLNTELRKLRGFHQES--ELEVHAFDKKLEEMS 674
Score = 53.1 bits (126), Expect = 5e-07
Identities = 84/402 (20%), Positives = 181/402 (45%), Gaps = 41/402 (10%)
Query: 68 RLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCT 127
R+ELE +E NI+ ++ + + L E AH E ++ KDI+I +C
Sbjct: 188 RVELEAV-SEQKRNIM-KDMMKLELDLHG-LREETSAHIE--RKDKDITIL------QCR 236
Query: 128 LLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLT- 186
L E QLE+T+ L ++++K + + + + EK+ Q++ + L+K LEK+ T
Sbjct: 237 LQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQ-NSLLKKEKELEKQQCMATE 295
Query: 187 ---TTQKTAEDKIKHLEEKLKEEEHQR---KLFQDKASELQTGLEISKIIMSSVSNLKHS 240
T ++ +DK K E K + E Q+ L + K E + ++ + H
Sbjct: 296 LEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHL 355
Query: 241 KEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPS 300
++ ++ +K + ++ I R+ +LQK ++ E
Sbjct: 356 EDTQRKLQKGLLLDKQKADTI-------------QELQRELQMLQKESSMAEKEQTSNRK 402
Query: 301 RTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMK--ETESHSVCD 358
R + + + +++ +N + +Q + + M+ ++L ++K E S+
Sbjct: 403 RV----EELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKC 458
Query: 359 DIECELECLLKKMEIKGEQISKLKKHQDSV-CKLQQKVQNSKMSEASGIQQEDSYPKGSK 417
+E +L+ K +E K EQ+ K K+H+ + +L+ Q K + + + + ++
Sbjct: 459 KLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENE 518
Query: 418 NIKNSPRKCLT--DTNLFQKNSSFHPIRVHNLQMKLRRDDIM 457
N++ + C T +++L + N+S I+ N ++ L+++ +M
Sbjct: 519 NLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLM 560
Score = 30.4 bits (67), Expect = 3.5
Identities = 40/165 (24%), Positives = 78/165 (47%), Gaps = 23/165 (13%)
Query: 60 KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQL 119
K LQ++ H L+ T ++ + LSR++A + L + N + + K + L
Sbjct: 568 KALQKEKHYLQT--TITKEAYDALSRKSAACQDDLTQALEKLN----HVTSETKSLQQSL 621
Query: 120 SSAQSRCTLLEKQL-EYTKRMV-LNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDV 177
+ Q + LE+++ Y +RM LN E K Q+++L+ ++A +KL+
Sbjct: 622 TQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELE---------VHAFDKKLE- 671
Query: 178 LEKECFRLTTTQKTAEDKIKHL---EEKLKEEEHQRKLFQDKASE 219
E C ++ QK ++ +K L EE+L+E + + ++ E
Sbjct: 672 -EMSC-QVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLE 714
>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform
a [Homo sapiens]
Length = 1007
Score = 56.2 bits (134), Expect = 6e-08
Identities = 91/416 (21%), Positives = 180/416 (43%), Gaps = 73/416 (17%)
Query: 32 QNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYK 91
Q C LE+T + + +A K LQ ++ +L+ +A+ + +++AAQ K
Sbjct: 434 QQCMATELEMTVKEAKQDKSKEA---ECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCK 490
Query: 92 K-----ALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVERE 146
+ E +R L L+ ++K +IQ L+++L+ +++E
Sbjct: 491 EEAALAGCHLEDTQRKLQKGLLLDKQKADTIQE---------LQRELQM-------LQKE 534
Query: 147 KNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAE-------DKIKH- 198
+M ++Q ++ E+ ++L L KL+ +KE +L T + D+IKH
Sbjct: 535 SSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQ 594
Query: 199 ------LEEKLKEE-EHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTK 251
++ KL+E+ + KL +DK +L+ E K++ + L+ +KK + K
Sbjct: 595 HREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKEN 654
Query: 252 CIK-------RRPPWQICS--------KFGALPFVAEKMRQHRDPHILQKPFNVTETRCL 296
K R Q CS K+ V + + + LQK ++ L
Sbjct: 655 SRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKE---IALQKESLMSLQAQL 711
Query: 297 PKP-------SRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMK 349
K +TT +A S KS + D+L++ L ++L+ ++ E + L + +
Sbjct: 712 DKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQAL----EKLNHVTSETKSLQQSLT 767
Query: 350 ETESHSVCDDIECELECLLKKMEIKGEQISKLKK-HQDSVCKLQQKVQNSKMSEAS 404
+T+ +E E+ ++M+ ++ KL+ HQ+S +L+ + K+ E S
Sbjct: 768 QTQEKKA--QLEEEIIAYEERMKKLNTELRKLRGFHQES--ELEVHAFDKKLEEMS 819
Score = 53.1 bits (126), Expect = 5e-07
Identities = 84/402 (20%), Positives = 181/402 (45%), Gaps = 41/402 (10%)
Query: 68 RLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCT 127
R+ELE +E NI+ ++ + + L E AH E ++ KDI+I +C
Sbjct: 333 RVELEAV-SEQKRNIM-KDMMKLELDLHG-LREETSAHIE--RKDKDITIL------QCR 381
Query: 128 LLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLT- 186
L E QLE+T+ L ++++K + + + + EK+ Q++ + L+K LEK+ T
Sbjct: 382 LQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQ-NSLLKKEKELEKQQCMATE 440
Query: 187 ---TTQKTAEDKIKHLEEKLKEEEHQR---KLFQDKASELQTGLEISKIIMSSVSNLKHS 240
T ++ +DK K E K + E Q+ L + K E + ++ + H
Sbjct: 441 LEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHL 500
Query: 241 KEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPS 300
++ ++ +K + ++ I R+ +LQK ++ E
Sbjct: 501 EDTQRKLQKGLLLDKQKADTI-------------QELQRELQMLQKESSMAEKEQTSNRK 547
Query: 301 RTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMK--ETESHSVCD 358
R + + + +++ +N + +Q + + M+ ++L ++K E S+
Sbjct: 548 RV----EELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKC 603
Query: 359 DIECELECLLKKMEIKGEQISKLKKHQDSV-CKLQQKVQNSKMSEASGIQQEDSYPKGSK 417
+E +L+ K +E K EQ+ K K+H+ + +L+ Q K + + + + ++
Sbjct: 604 KLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENE 663
Query: 418 NIKNSPRKCLT--DTNLFQKNSSFHPIRVHNLQMKLRRDDIM 457
N++ + C T +++L + N+S I+ N ++ L+++ +M
Sbjct: 664 NLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLM 705
Score = 47.8 bits (112), Expect = 2e-05
Identities = 69/338 (20%), Positives = 137/338 (40%), Gaps = 38/338 (11%)
Query: 60 KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQL 119
KTL+E +LE E L S + LE+ N+ N + Q + K+I++Q
Sbjct: 649 KTLKENSRKLEEENENLRAELQCCSTQ-------LESSLNKYNTSQQVIQDLNKEIALQK 701
Query: 120 SSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLE 179
S S L+K L+ K + + + E L R+ Q L LEKL+
Sbjct: 702 ESLMSLQAQLDKALQKEKHYL-----QTTITKEAYDALSRKSAACQDDLTQALEKLN--- 753
Query: 180 KECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKH 239
+T+ K+ + + +EK + E + ++++ +L T L + H
Sbjct: 754 ----HVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRGFHQESELEVH 809
Query: 240 SKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETR---CL 296
+ +KK + ++ + Q + L E++R+ ++ K + + + CL
Sbjct: 810 AFDKKLEEMSCQVLQWQKQHQ--NDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCL 867
Query: 297 PKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQM-----KET 351
P+ S C+ + + I NL + + +++ + +E +K + ++
Sbjct: 868 PQWSVPKDTCRLYRGNDQ----IMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKD 923
Query: 352 ESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVC 389
HSV ++ E + L K++E K K+K +C
Sbjct: 924 HLHSVMVHLQQENKKLKKEIEEK-----KMKAENTRLC 956
Score = 35.8 bits (81), Expect = 0.084
Identities = 73/393 (18%), Positives = 152/393 (38%), Gaps = 58/393 (14%)
Query: 51 NSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAH----- 105
+ Q + L+ L++K+ L+ E + L QY+ LE +T++ L H
Sbjct: 75 SKQCHLRQLQQLKKKLLVLQQELEFHTEELQTSYYSLRQYQSILEKQTSDLVLLHHHCKL 134
Query: 106 --QELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQ 163
E+I ++++ + + L ++QL + ++ER N L R+K Q
Sbjct: 135 KEDEVILYEEEMGNHNENTGEKLHLAQEQLALAGDKIASLERSLN--------LYRDKYQ 186
Query: 164 DQMKLYAKLE-KLDVLEKECFRLTTTQ---KTAEDKIKHLEEKLKEEEHQRKLFQDKASE 219
+ LE ++ +L+ E + + K K++ +EHQ Q + SE
Sbjct: 187 SSLSNIELLECQVKMLQGELGGIMGQEPENKGDHSKVRIYTSPCMIQEHQET--QKRLSE 244
Query: 220 LQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHR 279
+ + ++ + N ++ IK + + C+ HR
Sbjct: 245 VWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCT------------ATHR 292
Query: 280 DPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSM 339
P P + E + K K + + + L+ ++ EL+ +S
Sbjct: 293 YP-----PSSSEECEDIKK------ILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAVSE 341
Query: 340 EHQELLKQM-----------KETESHSVCDDIECE-LECLLKKMEIKGEQISKLKKHQDS 387
+ + ++K M +ET +H D + L+C L++++++ + KL +D
Sbjct: 342 QKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDK 401
Query: 388 VCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIK 420
LQ+K + + E Q ++S K K ++
Sbjct: 402 F--LQEKDEMLQELEKKLTQVQNSLLKKEKELE 432
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 56.2 bits (134), Expect = 6e-08
Identities = 79/357 (22%), Positives = 157/357 (43%), Gaps = 70/357 (19%)
Query: 53 QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETN--ERNLAHQ--EL 108
Q L+ A LQE LE E+ Q ++ +LSR+ K+A++ E E+ L + +L
Sbjct: 1950 QELLCASNRLQE----LEAEQQQIQEERELLSRQ----KEAMKAEAGPVEQQLLQETEKL 2001
Query: 109 IKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKL 168
+K+K ++ Q + L+KQ+ K + ++VE + + +E L++EK + M L
Sbjct: 2002 MKEKLEVQCQAEKVRDD---LQKQV---KALEIDVEEQVSRFIE----LEQEKNTELMDL 2051
Query: 169 YAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISK 228
+ + L+ K E K L+E+ + EH+R +FQ + +L+ L++
Sbjct: 2052 RQQNQALE-------------KQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVP 2098
Query: 229 IIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPF 288
+ E+ + K K K CS+ ++ Q R+ I + F
Sbjct: 2099 RFQPISEHQTREVEQLANHLKEKTDK-------CSELLLSKEQLQRDIQERNEEIEKLEF 2151
Query: 289 NVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQM 348
V E +A+ + K + EL + +Q + ++ +++ +E
Sbjct: 2152 RVRELE------------QALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKE----- 2194
Query: 349 KETESHSVCDDIECELECLLKKMEIKGEQISKLK-----KHQDSVCKLQQKVQNSKM 400
KE ++E +LE +++E K E++ +L + ++S +LQ+ Q +K+
Sbjct: 2195 KE------ITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKL 2245
Score = 45.8 bits (107), Expect = 8e-05
Identities = 46/213 (21%), Positives = 103/213 (48%), Gaps = 21/213 (9%)
Query: 54 ALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKK 113
+L + L+ ++ I R E E T E+ L Q+++ LEN+ E H +L QKK
Sbjct: 2178 SLEVQLQAERDAIDRKEKEITNLEEQLE-------QFREELENKNEEVQQLHMQLEIQKK 2230
Query: 114 DISIQLSSAQSRCTLLEKQLEYTKRMVLNVE----REKNMILEQQAQLQREKEQDQMKLY 169
+ + +L + L + +E + + ++++++ + AQ+ +EKE + +L
Sbjct: 2231 ESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLN 2290
Query: 170 AKLEKLDVLEKECFRLTTTQKTAEDK---IKHLEEKLK-EEEHQRKLFQDKASELQTGLE 225
++ KL ++ ++TT K E+K I+ LE +++ Q + +++ E++ E
Sbjct: 2291 EQVTKL----QQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNE 2346
Query: 226 ISKIIMSSVSNL--KHSKEKKKSSKKTKCIKRR 256
+ + + ++N+ K S S++ +K +
Sbjct: 2347 VIEKLQQELANIGQKTSMNAHSLSEEADSLKHQ 2379
Score = 45.1 bits (105), Expect = 1e-04
Identities = 82/380 (21%), Positives = 162/380 (42%), Gaps = 39/380 (10%)
Query: 53 QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQK 112
QA + L+ + E++ A+ N ++ + Q + E E N+ ++ Q
Sbjct: 3068 QAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQ--SQM 3125
Query: 113 KDISIQLSSAQSRCTLLEKQLEYTKRMVLNVERE---KNMILEQ--QAQLQREKEQDQMK 167
++ ++LSS + R T L++QL K +V ++ E + LE +AQ + KE + +
Sbjct: 3126 LEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFR 3185
Query: 168 LYAKLEKLDVLEKECFRLTTTQKTAED----------KIKHLEEKLKEEEHQRKLFQDKA 217
L K +K D + L + QK + + K+ EE+ KEE K +
Sbjct: 3186 LEVK-DKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLE-- 3242
Query: 218 SELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIK------RRPPWQIC--SKFGALP 269
S+ Q L+++ ++ L S++K +S + + R Q+ S+ +
Sbjct: 3243 SQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIR 3302
Query: 270 FVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPD-SEKSISICDNLSELLM 328
++ + + R+ H + + T P PS K + EK I + L+E
Sbjct: 3303 EMSSTLDRERELHAQLQSSDGTGQSRPPLPSE--DLLKELQKQLEEKHSRIVELLNETEK 3360
Query: 329 AMQDELD-QMSME-----HQELLKQMKE--TESHSVCDDIECELECLLKKMEIKGEQISK 380
D L + ME H++ L+ +E TE +++ ++E L +++E K +Q+ K
Sbjct: 3361 YKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYK 3420
Query: 381 LKKHQDSVCKLQQKVQNSKM 400
L + + Q+ Q ++
Sbjct: 3421 LDLEGQRLQGIMQEFQKQEL 3440
Score = 42.7 bits (99), Expect = 7e-04
Identities = 76/374 (20%), Positives = 156/374 (41%), Gaps = 51/374 (13%)
Query: 57 LALKTLQEKIHRLELER--TQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKD 114
L K ++E+ LEL+ T A+ L L + Q + ++N E + Q+ + ++
Sbjct: 334 LNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEE 393
Query: 115 ISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQ-QAQLQREKEQDQMKLYAKLE 173
I + + + K ++ +V +E+E LEQ +A+L Q +++ +L
Sbjct: 394 IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELI 453
Query: 174 KLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSS 233
+ + + E + T K + + E Q KL +EL L+ +
Sbjct: 454 RQHMAQME--EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQ------DT 505
Query: 234 VSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTET 293
S + KE+ + KC +R Q+ L F E++++ R I ++ + E
Sbjct: 506 NSQKEKLKEELGLILEEKCALQR---QLEDLVEELSFSREQIQRARQT-IAEQESKLNE- 560
Query: 294 RCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQ------ELLKQ 347
+ KS+S ++L +++ + ++ ++H+ ++ +
Sbjct: 561 -------------------AHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLE 601
Query: 348 MKETESHSVCDDI----ECELECLLKKMEIK-GEQISKLK-----KHQDSVCKLQQKVQN 397
M E E ++V D + E ELE L ++ E++SKLK +H+ ++ KL+ +
Sbjct: 602 MLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGI 661
Query: 398 SKMSEASGIQQEDS 411
+ G+Q E S
Sbjct: 662 HYKQQIDGLQNEMS 675
Score = 41.6 bits (96), Expect = 0.002
Identities = 64/269 (23%), Positives = 109/269 (40%), Gaps = 20/269 (7%)
Query: 52 SQALILALKTLQEKIHRLE-LERTQAED---NLNILSREAAQYKKALENETNERNLAHQE 107
S+ L AL+ + K+ R E ++ + ED +L + Q LE + N + Q+
Sbjct: 3209 SRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQK 3268
Query: 108 LIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMK 167
+ Q+ QLS Q R L+ LE K + + + E AQLQ Q +
Sbjct: 3269 IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSR 3328
Query: 168 -------LYAKLEKLDVLEKECFR----LTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDK 216
L +L+K LE++ R L T+K D ++ ++ K+ + RK Q +
Sbjct: 3329 PPLPSEDLLKELQK--QLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTE 3386
Query: 217 ASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMR 276
G + + S V +L+ E+K+ ++ + I +F E+ R
Sbjct: 3387 QEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKR 3446
Query: 277 QHRDPHILQKPFNVTETRCLPKPSRTTSW 305
+ R IL + N T L RT +W
Sbjct: 3447 ESR--RILYQNLNEPTTWSLTS-DRTRNW 3472
Score = 38.5 bits (88), Expect = 0.013
Identities = 51/197 (25%), Positives = 91/197 (46%), Gaps = 27/197 (13%)
Query: 37 ANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNI--------LSREAA 88
A LE ++L S + + LK E HR+ +E+ + DNL I L E +
Sbjct: 620 AELERLRTQLLFSHEEE--LSKLKEDLEIEHRINIEKLK--DNLGIHYKQQIDGLQNEMS 675
Query: 89 QYKKALENETNERNLAHQELI---KQKKDISIQLSSAQSR-CTLLEKQLEYTKRMVLNVE 144
Q + ++ E + +LI + KD+ L +++S TL +L+ ++ E
Sbjct: 676 QKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEE 735
Query: 145 REKNMILE--QQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEK 202
+EK + + Q+ QL+ E + QMK EK + L+++ +L +D+ K LE+
Sbjct: 736 KEKGTLEQEVQELQLKTELLEKQMK-----EKENDLQEKFAQLEAENSILKDEKKTLEDM 790
Query: 203 LK----EEEHQRKLFQD 215
LK + +R +F D
Sbjct: 791 LKIHTPVSQEERLIFLD 807
Score = 38.5 bits (88), Expect = 0.013
Identities = 74/380 (19%), Positives = 150/380 (39%), Gaps = 65/380 (17%)
Query: 63 QEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSA 122
Q++I +LE ++ + +S + + L N E+ EL+ K+ + +
Sbjct: 2084 QQEIQKLE-QQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQER 2142
Query: 123 QSRCTLLEKQLEYTKRMVL--------NVEREKNMILEQQAQLQRE----KEQDQMKLYA 170
LE ++ ++ +L VE + + LE Q Q +R+ KE++ L
Sbjct: 2143 NEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEE 2202
Query: 171 KLEKL-DVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISK- 228
+LE+ + LE + + E + K +L+E E + KLF+D +L ++ S
Sbjct: 2203 QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDA 2262
Query: 229 -------IIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDP 281
++ + + KE + + K + +I + + EK RD
Sbjct: 2263 MSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKV---IEEKNELIRDL 2319
Query: 282 HILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDEL------- 334
T+ CL + + + E+ I + L+E++ +Q EL
Sbjct: 2320 E--------TQIECLMSDQ------ECVKRNREEEI---EQLNEVIEKLQQELANIGQKT 2362
Query: 335 ----DQMSMEHQELLKQMKETESHSVCDDIECE--------LECLLKKMEIKGEQISK-- 380
+S E L Q+ + + + + E ++ +LK+ K Q+++
Sbjct: 2363 SMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQEL 2422
Query: 381 --LKKHQDSVCKLQQKVQNS 398
LK+ ++SV K+Q +NS
Sbjct: 2423 FSLKRERESVEKIQSIPENS 2442
Score = 38.1 bits (87), Expect = 0.017
Identities = 69/340 (20%), Positives = 147/340 (43%), Gaps = 48/340 (14%)
Query: 52 SQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKK----ALENETNERNLAHQE 107
S L A++ L E I + A+ L RE+ + K+ +L+ + R H+E
Sbjct: 1847 SSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEE 1906
Query: 108 LIKQKKDISIQLSSAQS-------RCTLLEKQLEYTKRMVLNVERE----KNMILEQQAQ 156
+ ++ ++++LS A+ TL E+Q++ ++ +E+E N + E +A+
Sbjct: 1907 S-RAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAE 1965
Query: 157 LQR-EKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQD 215
Q+ ++E++ + + K + E L T+K ++K++ + K + +K Q
Sbjct: 1966 QQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQK--QV 2023
Query: 216 KASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKM 275
KA E+ ++S+ I + + K T+ + R Q AL EKM
Sbjct: 2024 KALEIDVEEQVSRFI------------ELEQEKNTELMDLRQQNQ------ALEKQLEKM 2065
Query: 276 RQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIP---PDSEKSISICDNLSELLMAMQD 332
R+ D + + + + + K +P P SE + L+ L D
Sbjct: 2066 RKFLDEQAIDREHERDVFQ--QEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTD 2123
Query: 333 ELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKME 372
+ ++ + ++L + ++E ++IE +LE ++++E
Sbjct: 2124 KCSELLLSKEQLQRDIQERN-----EEIE-KLEFRVRELE 2157
Score = 36.6 bits (83), Expect = 0.049
Identities = 48/201 (23%), Positives = 90/201 (44%), Gaps = 24/201 (11%)
Query: 62 LQEKIHRLELERTQAEDNLNILSREAAQYKKAL---ENETNERNLAHQELIKQKKDISIQ 118
LQ + +L+ T + + + Q K+ + + + E++ ++ K+K+D ++Q
Sbjct: 238 LQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQ 297
Query: 119 LSSAQSRCTLLE----KQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEK 174
+S Q + + E K++E + + + +EK I+E+ E+E+ ++L KL
Sbjct: 298 ISFLQEKIKVYEMEQDKKVENSNKEEI---QEKETIIEELNTKIIEEEKKTLELKDKLTT 354
Query: 175 LDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSV 234
D L E + QK E K LE L K E Q+ EI K +M +V
Sbjct: 355 ADKLLGE-LQEQIVQKNQEIKNMKLE-----------LTNSKQKERQSSEEI-KQLMGTV 401
Query: 235 SNLKHSKEKKKSSKKTKCIKR 255
L+ + K S +T ++R
Sbjct: 402 EELQ-KRNHKDSQFETDIVQR 421
Score = 35.8 bits (81), Expect = 0.084
Identities = 62/345 (17%), Positives = 138/345 (40%), Gaps = 38/345 (11%)
Query: 57 LALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDIS 116
+A+ L K+ ++ + ++ L ++ E ++ LE+ E + + +++ + ++ I+
Sbjct: 493 VAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIA 552
Query: 117 IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLD 176
Q S L + +V E K + L+ +A++ K KL+
Sbjct: 553 EQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKI-----------KLE 601
Query: 177 VLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLF--QDKASELQTGLEISKIIMSSV 234
+LEKE + D++ +E E + LF +++ S+L+ LEI I
Sbjct: 602 MLEKE-------KNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRI---- 650
Query: 235 SNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETR 294
N++ K+ K QI + E M+ +D I ++ + E
Sbjct: 651 -NIEKLKDNLGIHYKQ---------QIDGLQNEMSQKIETMQFEKDNLITKQNQLILEIS 700
Query: 295 CLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESH 354
L ++ K+ E ++ I + E+ + Q+E ++ ++E + Q+K
Sbjct: 701 KLKDLQQSLVNSKS----EEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLE 756
Query: 355 SVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSK 399
+ E +L+ ++E + + KK + + K+ V +
Sbjct: 757 KQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEE 801
Score = 33.9 bits (76), Expect = 0.32
Identities = 43/212 (20%), Positives = 89/212 (41%), Gaps = 26/212 (12%)
Query: 58 ALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISI 117
ALK+L+ + + E +N+ +R LE+ + ++L + KQ KD+
Sbjct: 2465 ALKSLENQTYFKSFEENGKGSIINLETRLLQ-----LESTVSAKDLELTQCYKQIKDMQE 2519
Query: 118 QLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKE-----QDQMKLYAKL 172
Q Q +L+K++ +++V E + L Q QL+ +E QD + ++
Sbjct: 2520 Q---GQFETEMLQKKIVNLQKIV---EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEP 2573
Query: 173 EKLDV----------LEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQT 222
E+ ++ L + LT E ++ + L E+ Q ++ + E +
Sbjct: 2574 ERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEK 2633
Query: 223 GLEISKIIMSSVSNLKHSKEKKKSSKKTKCIK 254
L + ++ + KEKK+S + + +K
Sbjct: 2634 KLLELQKLLEGNEKKQREKEKKRSPQDVEVLK 2665
Score = 33.9 bits (76), Expect = 0.32
Identities = 42/208 (20%), Positives = 104/208 (50%), Gaps = 19/208 (9%)
Query: 53 QALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQK 112
+A I + +L++ I +++L+R +AE +++Q ++ + E LA Q++ ++
Sbjct: 2977 KAYINTISSLKDLITKMQLQR-EAE------VYDSSQSHESFSDWRGELLLALQQVFLEE 3029
Query: 113 KDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKL 172
+ S+ L++ ++ T L L +R + +E QA ++ ++ D+ L +++
Sbjct: 3030 R--SVLLAAFRTELTALGTTDAVGLLNCLE-QRIQEQGVEYQAAMECLQKADRRSLLSEI 3086
Query: 173 EKLDV--------LEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGL 224
+ L L++E +Q+ E I+ + ++ E + + +D+A+ELQ L
Sbjct: 3087 QALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQL 3146
Query: 225 EISKIIMSSV-SNLKHSKEKKKSSKKTK 251
K++++ + S L +K + +++ K +
Sbjct: 3147 SSEKMVVAELKSELAQTKLELETTLKAQ 3174
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 55.1 bits (131), Expect = 1e-07
Identities = 52/235 (22%), Positives = 116/235 (49%), Gaps = 21/235 (8%)
Query: 40 EVTSPKILHSPNSQALILALKTLQEKIHRLELERTQ--AED--NLNILSREAAQYKKALE 95
E++ K ++ALIL K ++ + E E+ + AE+ L++ ++EAA+ ++ E
Sbjct: 2239 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2298
Query: 96 NETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQA 155
+ ++ ++++K+K + + ++ LL++Q E + ++ +K + +Q A
Sbjct: 2299 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2358
Query: 156 Q----LQREKE---QDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH 208
+ QR E Q Q+++ A+ E+L + E R + + + E++ E+ H
Sbjct: 2359 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2418
Query: 209 QRKL-FQDKASELQTGLEI--------SKIIMSSVSNLKHSKEKKKSSKKTKCIK 254
+ +L Q+K + +QT LEI ++ + +++ L+ KEK + K +K
Sbjct: 2419 RTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472
Score = 50.4 bits (119), Expect = 3e-06
Identities = 50/172 (29%), Positives = 86/172 (50%), Gaps = 12/172 (6%)
Query: 52 SQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQ 111
++AL L L+ +E + L + +AE REA + KA E +R LA QEL KQ
Sbjct: 1639 NEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697
Query: 112 KKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQRE---KEQDQMKL 168
++ + +AQ R E++L + E+++ ++ E+ A+LQRE Q + +L
Sbjct: 1698 RQ---LAEGTAQQRLAA-EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 169 YAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEE-EHQRKLFQDKASE 219
A+L K + E L ++ AE++ + EK K+ E + F++ A E
Sbjct: 1754 EAELAK---VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802
Score = 42.4 bits (98), Expect = 9e-04
Identities = 44/197 (22%), Positives = 86/197 (43%), Gaps = 9/197 (4%)
Query: 60 KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIK---QKKDIS 116
++LQE+ + R +AE EA + ++ E E L E ++ Q ++++
Sbjct: 1594 RSLQEEHVAVAQLREEAERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1652
Query: 117 IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLD 176
Q S AQ+ EKQ E +R + + + Q+ ++E E+ + ++
Sbjct: 1653 QQKSLAQAEA---EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1709
Query: 177 VLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSV-- 234
E+E RL + E + + LEE+L + + K EL+ L + M +
Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1769
Query: 235 SNLKHSKEKKKSSKKTK 251
S + +E + +S+K+K
Sbjct: 1770 SKARAEEESRSTSEKSK 1786
Score = 40.4 bits (93), Expect = 0.003
Identities = 42/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)
Query: 64 EKIHRLEL---ERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS 120
EK+HR EL E+ L I +++ + L E ++L ++ K +QL
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK--LLQLK 2472
Query: 121 SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREK---EQDQMKLYAKLEKL-- 175
S + + E+ L+ T+ + + EK+ +L+++ +++EK EQ AK ++L
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532
Query: 176 ------DVLEKECFRLTTT-------QKTAEDKIKHLEEKLKEEEHQRKLFQDKASE 219
+E+E RL + Q AE+ ++ +E+L++ E QR+ ++ +E
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2589
Score = 38.5 bits (88), Expect = 0.013
Identities = 36/182 (19%), Positives = 83/182 (45%), Gaps = 5/182 (2%)
Query: 62 LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSS 121
L+E++ RL+ E A L E A+ + +E + A +E + +L +
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Query: 122 AQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKE 181
R L ++ + + +R++ + E A+ + E E+ + A + + L+ E
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1851
Query: 182 CFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLE--ISKIIMSSVSNLKH 239
+ +K AE+ + L ++E QR+ +++A++ + +E ++++ +S S L+
Sbjct: 1852 A-EIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1908
Query: 240 SK 241
K
Sbjct: 1909 QK 1910
Score = 37.0 bits (84), Expect = 0.038
Identities = 55/195 (28%), Positives = 87/195 (44%), Gaps = 22/195 (11%)
Query: 29 EPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAA 88
+ SQ A +E+ S + ++ AL+ L+E L L+ +AE L E A
Sbjct: 1505 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRLQAEEAERRLRQAEVERA 1560
Query: 89 -QYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREK 147
Q + ALE T +R+ A EL Q K S +AQ LE+ L+ V + E
Sbjct: 1561 RQVQVALE--TAQRS-AEAEL--QSKRASFAEKTAQ-----LERSLQEEHVAVAQLREEA 1610
Query: 148 NMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRL-TTTQKTAEDK--IKHLEEKLK 204
+QQA+ +R +E+ + +LE+ + E RL ++ A+ K + EK K
Sbjct: 1611 ERRAQQQAEAERAREEAE----RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 205 EEEHQRKLFQDKASE 219
EE + + KA E
Sbjct: 1667 EEAEREARRRGKAEE 1681
Score = 32.3 bits (72), Expect = 0.93
Identities = 40/192 (20%), Positives = 79/192 (41%), Gaps = 20/192 (10%)
Query: 62 LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSS 121
+Q+K L+ Q + L+ L EA ++A E R A +E + ++ Q+
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR----QVEE 2113
Query: 122 AQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKE 181
A+ E+Q + + E+ + EQ+A + + EQ ++ + K+
Sbjct: 2114 AERLKQSAEEQAQARAQAQAAAEKLRKEA-EQEAARRAQAEQAALRQKQAADAEMEKHKK 2172
Query: 182 CFRLTTTQKT-AEDKIKHLEEKLKEEEHQRKLFQDKA--------------SELQTGLEI 226
T QK E ++ L +L+E +HQ+ L ++ S+++ L
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232
Query: 227 SKIIMSSVSNLK 238
++ M +S LK
Sbjct: 2233 VRVQMEELSKLK 2244
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 55.1 bits (131), Expect = 1e-07
Identities = 52/235 (22%), Positives = 116/235 (49%), Gaps = 21/235 (8%)
Query: 40 EVTSPKILHSPNSQALILALKTLQEKIHRLELERTQ--AED--NLNILSREAAQYKKALE 95
E++ K ++ALIL K ++ + E E+ + AE+ L++ ++EAA+ ++ E
Sbjct: 2243 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2302
Query: 96 NETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQA 155
+ ++ ++++K+K + + ++ LL++Q E + ++ +K + +Q A
Sbjct: 2303 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2362
Query: 156 Q----LQREKE---QDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH 208
+ QR E Q Q+++ A+ E+L + E R + + + E++ E+ H
Sbjct: 2363 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2422
Query: 209 QRKL-FQDKASELQTGLEI--------SKIIMSSVSNLKHSKEKKKSSKKTKCIK 254
+ +L Q+K + +QT LEI ++ + +++ L+ KEK + K +K
Sbjct: 2423 RTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2476
Score = 50.4 bits (119), Expect = 3e-06
Identities = 50/172 (29%), Positives = 86/172 (50%), Gaps = 12/172 (6%)
Query: 52 SQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQ 111
++AL L L+ +E + L + +AE REA + KA E +R LA QEL KQ
Sbjct: 1643 NEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1701
Query: 112 KKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQRE---KEQDQMKL 168
++ + +AQ R E++L + E+++ ++ E+ A+LQRE Q + +L
Sbjct: 1702 RQ---LAEGTAQQRLAA-EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1757
Query: 169 YAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEE-EHQRKLFQDKASE 219
A+L K + E L ++ AE++ + EK K+ E + F++ A E
Sbjct: 1758 EAELAK---VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1806
Score = 42.4 bits (98), Expect = 9e-04
Identities = 44/197 (22%), Positives = 86/197 (43%), Gaps = 9/197 (4%)
Query: 60 KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIK---QKKDIS 116
++LQE+ + R +AE EA + ++ E E L E ++ Q ++++
Sbjct: 1598 RSLQEEHVAVAQLREEAERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1656
Query: 117 IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLD 176
Q S AQ+ EKQ E +R + + + Q+ ++E E+ + ++
Sbjct: 1657 QQKSLAQAEA---EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1713
Query: 177 VLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSV-- 234
E+E RL + E + + LEE+L + + K EL+ L + M +
Sbjct: 1714 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1773
Query: 235 SNLKHSKEKKKSSKKTK 251
S + +E + +S+K+K
Sbjct: 1774 SKARAEEESRSTSEKSK 1790
Score = 40.4 bits (93), Expect = 0.003
Identities = 42/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)
Query: 64 EKIHRLEL---ERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS 120
EK+HR EL E+ L I +++ + L E ++L ++ K +QL
Sbjct: 2419 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK--LLQLK 2476
Query: 121 SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREK---EQDQMKLYAKLEKL-- 175
S + + E+ L+ T+ + + EK+ +L+++ +++EK EQ AK ++L
Sbjct: 2477 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2536
Query: 176 ------DVLEKECFRLTTT-------QKTAEDKIKHLEEKLKEEEHQRKLFQDKASE 219
+E+E RL + Q AE+ ++ +E+L++ E QR+ ++ +E
Sbjct: 2537 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2593
Score = 38.5 bits (88), Expect = 0.013
Identities = 36/182 (19%), Positives = 83/182 (45%), Gaps = 5/182 (2%)
Query: 62 LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSS 121
L+E++ RL+ E A L E A+ + +E + A +E + +L +
Sbjct: 1736 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1795
Query: 122 AQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKE 181
R L ++ + + +R++ + E A+ + E E+ + A + + L+ E
Sbjct: 1796 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1855
Query: 182 CFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLE--ISKIIMSSVSNLKH 239
+ +K AE+ + L ++E QR+ +++A++ + +E ++++ +S S L+
Sbjct: 1856 A-EIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1912
Query: 240 SK 241
K
Sbjct: 1913 QK 1914
Score = 37.0 bits (84), Expect = 0.038
Identities = 55/195 (28%), Positives = 87/195 (44%), Gaps = 22/195 (11%)
Query: 29 EPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAA 88
+ SQ A +E+ S + ++ AL+ L+E L L+ +AE L E A
Sbjct: 1509 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRLQAEEAERRLRQAEVERA 1564
Query: 89 -QYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREK 147
Q + ALE T +R+ A EL Q K S +AQ LE+ L+ V + E
Sbjct: 1565 RQVQVALE--TAQRS-AEAEL--QSKRASFAEKTAQ-----LERSLQEEHVAVAQLREEA 1614
Query: 148 NMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRL-TTTQKTAEDK--IKHLEEKLK 204
+QQA+ +R +E+ + +LE+ + E RL ++ A+ K + EK K
Sbjct: 1615 ERRAQQQAEAERAREEAE----RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1670
Query: 205 EEEHQRKLFQDKASE 219
EE + + KA E
Sbjct: 1671 EEAEREARRRGKAEE 1685
Score = 32.3 bits (72), Expect = 0.93
Identities = 40/192 (20%), Positives = 79/192 (41%), Gaps = 20/192 (10%)
Query: 62 LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSS 121
+Q+K L+ Q + L+ L EA ++A E R A +E + ++ Q+
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR----QVEE 2117
Query: 122 AQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKE 181
A+ E+Q + + E+ + EQ+A + + EQ ++ + K+
Sbjct: 2118 AERLKQSAEEQAQARAQAQAAAEKLRKEA-EQEAARRAQAEQAALRQKQAADAEMEKHKK 2176
Query: 182 CFRLTTTQKT-AEDKIKHLEEKLKEEEHQRKLFQDKA--------------SELQTGLEI 226
T QK E ++ L +L+E +HQ+ L ++ S+++ L
Sbjct: 2177 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2236
Query: 227 SKIIMSSVSNLK 238
++ M +S LK
Sbjct: 2237 VRVQMEELSKLK 2248
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 55.1 bits (131), Expect = 1e-07
Identities = 52/235 (22%), Positives = 116/235 (49%), Gaps = 21/235 (8%)
Query: 40 EVTSPKILHSPNSQALILALKTLQEKIHRLELERTQ--AED--NLNILSREAAQYKKALE 95
E++ K ++ALIL K ++ + E E+ + AE+ L++ ++EAA+ ++ E
Sbjct: 2239 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2298
Query: 96 NETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQA 155
+ ++ ++++K+K + + ++ LL++Q E + ++ +K + +Q A
Sbjct: 2299 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2358
Query: 156 Q----LQREKE---QDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH 208
+ QR E Q Q+++ A+ E+L + E R + + + E++ E+ H
Sbjct: 2359 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2418
Query: 209 QRKL-FQDKASELQTGLEI--------SKIIMSSVSNLKHSKEKKKSSKKTKCIK 254
+ +L Q+K + +QT LEI ++ + +++ L+ KEK + K +K
Sbjct: 2419 RTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472
Score = 50.4 bits (119), Expect = 3e-06
Identities = 50/172 (29%), Positives = 86/172 (50%), Gaps = 12/172 (6%)
Query: 52 SQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQ 111
++AL L L+ +E + L + +AE REA + KA E +R LA QEL KQ
Sbjct: 1639 NEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697
Query: 112 KKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQRE---KEQDQMKL 168
++ + +AQ R E++L + E+++ ++ E+ A+LQRE Q + +L
Sbjct: 1698 RQ---LAEGTAQQRLAA-EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 169 YAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEE-EHQRKLFQDKASE 219
A+L K + E L ++ AE++ + EK K+ E + F++ A E
Sbjct: 1754 EAELAK---VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802
Score = 42.4 bits (98), Expect = 9e-04
Identities = 44/197 (22%), Positives = 86/197 (43%), Gaps = 9/197 (4%)
Query: 60 KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIK---QKKDIS 116
++LQE+ + R +AE EA + ++ E E L E ++ Q ++++
Sbjct: 1594 RSLQEEHVAVAQLREEAERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1652
Query: 117 IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLD 176
Q S AQ+ EKQ E +R + + + Q+ ++E E+ + ++
Sbjct: 1653 QQKSLAQAEA---EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1709
Query: 177 VLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSV-- 234
E+E RL + E + + LEE+L + + K EL+ L + M +
Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1769
Query: 235 SNLKHSKEKKKSSKKTK 251
S + +E + +S+K+K
Sbjct: 1770 SKARAEEESRSTSEKSK 1786
Score = 40.4 bits (93), Expect = 0.003
Identities = 42/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)
Query: 64 EKIHRLEL---ERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS 120
EK+HR EL E+ L I +++ + L E ++L ++ K +QL
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK--LLQLK 2472
Query: 121 SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREK---EQDQMKLYAKLEKL-- 175
S + + E+ L+ T+ + + EK+ +L+++ +++EK EQ AK ++L
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532
Query: 176 ------DVLEKECFRLTTT-------QKTAEDKIKHLEEKLKEEEHQRKLFQDKASE 219
+E+E RL + Q AE+ ++ +E+L++ E QR+ ++ +E
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2589
Score = 38.5 bits (88), Expect = 0.013
Identities = 36/182 (19%), Positives = 83/182 (45%), Gaps = 5/182 (2%)
Query: 62 LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSS 121
L+E++ RL+ E A L E A+ + +E + A +E + +L +
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Query: 122 AQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKE 181
R L ++ + + +R++ + E A+ + E E+ + A + + L+ E
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1851
Query: 182 CFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLE--ISKIIMSSVSNLKH 239
+ +K AE+ + L ++E QR+ +++A++ + +E ++++ +S S L+
Sbjct: 1852 A-EIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1908
Query: 240 SK 241
K
Sbjct: 1909 QK 1910
Score = 37.0 bits (84), Expect = 0.038
Identities = 55/195 (28%), Positives = 87/195 (44%), Gaps = 22/195 (11%)
Query: 29 EPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAA 88
+ SQ A +E+ S + ++ AL+ L+E L L+ +AE L E A
Sbjct: 1505 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRLQAEEAERRLRQAEVERA 1560
Query: 89 -QYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREK 147
Q + ALE T +R+ A EL Q K S +AQ LE+ L+ V + E
Sbjct: 1561 RQVQVALE--TAQRS-AEAEL--QSKRASFAEKTAQ-----LERSLQEEHVAVAQLREEA 1610
Query: 148 NMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRL-TTTQKTAEDK--IKHLEEKLK 204
+QQA+ +R +E+ + +LE+ + E RL ++ A+ K + EK K
Sbjct: 1611 ERRAQQQAEAERAREEAE----RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 205 EEEHQRKLFQDKASE 219
EE + + KA E
Sbjct: 1667 EEAEREARRRGKAEE 1681
Score = 32.3 bits (72), Expect = 0.93
Identities = 40/192 (20%), Positives = 79/192 (41%), Gaps = 20/192 (10%)
Query: 62 LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSS 121
+Q+K L+ Q + L+ L EA ++A E R A +E + ++ Q+
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR----QVEE 2113
Query: 122 AQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKE 181
A+ E+Q + + E+ + EQ+A + + EQ ++ + K+
Sbjct: 2114 AERLKQSAEEQAQARAQAQAAAEKLRKEA-EQEAARRAQAEQAALRQKQAADAEMEKHKK 2172
Query: 182 CFRLTTTQKT-AEDKIKHLEEKLKEEEHQRKLFQDKA--------------SELQTGLEI 226
T QK E ++ L +L+E +HQ+ L ++ S+++ L
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232
Query: 227 SKIIMSSVSNLK 238
++ M +S LK
Sbjct: 2233 VRVQMEELSKLK 2244
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 55.1 bits (131), Expect = 1e-07
Identities = 52/235 (22%), Positives = 116/235 (49%), Gaps = 21/235 (8%)
Query: 40 EVTSPKILHSPNSQALILALKTLQEKIHRLELERTQ--AED--NLNILSREAAQYKKALE 95
E++ K ++ALIL K ++ + E E+ + AE+ L++ ++EAA+ ++ E
Sbjct: 2207 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2266
Query: 96 NETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQA 155
+ ++ ++++K+K + + ++ LL++Q E + ++ +K + +Q A
Sbjct: 2267 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2326
Query: 156 Q----LQREKE---QDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH 208
+ QR E Q Q+++ A+ E+L + E R + + + E++ E+ H
Sbjct: 2327 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2386
Query: 209 QRKL-FQDKASELQTGLEI--------SKIIMSSVSNLKHSKEKKKSSKKTKCIK 254
+ +L Q+K + +QT LEI ++ + +++ L+ KEK + K +K
Sbjct: 2387 RTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2440
Score = 50.4 bits (119), Expect = 3e-06
Identities = 50/172 (29%), Positives = 86/172 (50%), Gaps = 12/172 (6%)
Query: 52 SQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQ 111
++AL L L+ +E + L + +AE REA + KA E +R LA QEL KQ
Sbjct: 1607 NEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1665
Query: 112 KKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQRE---KEQDQMKL 168
++ + +AQ R E++L + E+++ ++ E+ A+LQRE Q + +L
Sbjct: 1666 RQ---LAEGTAQQRLAA-EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1721
Query: 169 YAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEE-EHQRKLFQDKASE 219
A+L K + E L ++ AE++ + EK K+ E + F++ A E
Sbjct: 1722 EAELAK---VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1770
Score = 42.4 bits (98), Expect = 9e-04
Identities = 44/197 (22%), Positives = 86/197 (43%), Gaps = 9/197 (4%)
Query: 60 KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIK---QKKDIS 116
++LQE+ + R +AE EA + ++ E E L E ++ Q ++++
Sbjct: 1562 RSLQEEHVAVAQLREEAERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1620
Query: 117 IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLD 176
Q S AQ+ EKQ E +R + + + Q+ ++E E+ + ++
Sbjct: 1621 QQKSLAQAEA---EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1677
Query: 177 VLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSV-- 234
E+E RL + E + + LEE+L + + K EL+ L + M +
Sbjct: 1678 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1737
Query: 235 SNLKHSKEKKKSSKKTK 251
S + +E + +S+K+K
Sbjct: 1738 SKARAEEESRSTSEKSK 1754
Score = 40.4 bits (93), Expect = 0.003
Identities = 42/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)
Query: 64 EKIHRLEL---ERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS 120
EK+HR EL E+ L I +++ + L E ++L ++ K +QL
Sbjct: 2383 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK--LLQLK 2440
Query: 121 SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREK---EQDQMKLYAKLEKL-- 175
S + + E+ L+ T+ + + EK+ +L+++ +++EK EQ AK ++L
Sbjct: 2441 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2500
Query: 176 ------DVLEKECFRLTTT-------QKTAEDKIKHLEEKLKEEEHQRKLFQDKASE 219
+E+E RL + Q AE+ ++ +E+L++ E QR+ ++ +E
Sbjct: 2501 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2557
Score = 38.5 bits (88), Expect = 0.013
Identities = 36/182 (19%), Positives = 83/182 (45%), Gaps = 5/182 (2%)
Query: 62 LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSS 121
L+E++ RL+ E A L E A+ + +E + A +E + +L +
Sbjct: 1700 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1759
Query: 122 AQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKE 181
R L ++ + + +R++ + E A+ + E E+ + A + + L+ E
Sbjct: 1760 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1819
Query: 182 CFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLE--ISKIIMSSVSNLKH 239
+ +K AE+ + L ++E QR+ +++A++ + +E ++++ +S S L+
Sbjct: 1820 A-EIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1876
Query: 240 SK 241
K
Sbjct: 1877 QK 1878
Score = 37.0 bits (84), Expect = 0.038
Identities = 55/195 (28%), Positives = 87/195 (44%), Gaps = 22/195 (11%)
Query: 29 EPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAA 88
+ SQ A +E+ S + ++ AL+ L+E L L+ +AE L E A
Sbjct: 1473 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRLQAEEAERRLRQAEVERA 1528
Query: 89 -QYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREK 147
Q + ALE T +R+ A EL Q K S +AQ LE+ L+ V + E
Sbjct: 1529 RQVQVALE--TAQRS-AEAEL--QSKRASFAEKTAQ-----LERSLQEEHVAVAQLREEA 1578
Query: 148 NMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRL-TTTQKTAEDK--IKHLEEKLK 204
+QQA+ +R +E+ + +LE+ + E RL ++ A+ K + EK K
Sbjct: 1579 ERRAQQQAEAERAREEAE----RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1634
Query: 205 EEEHQRKLFQDKASE 219
EE + + KA E
Sbjct: 1635 EEAEREARRRGKAEE 1649
Score = 32.3 bits (72), Expect = 0.93
Identities = 40/192 (20%), Positives = 79/192 (41%), Gaps = 20/192 (10%)
Query: 62 LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSS 121
+Q+K L+ Q + L+ L EA ++A E R A +E + ++ Q+
Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR----QVEE 2081
Query: 122 AQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKE 181
A+ E+Q + + E+ + EQ+A + + EQ ++ + K+
Sbjct: 2082 AERLKQSAEEQAQARAQAQAAAEKLRKEA-EQEAARRAQAEQAALRQKQAADAEMEKHKK 2140
Query: 182 CFRLTTTQKT-AEDKIKHLEEKLKEEEHQRKLFQDKA--------------SELQTGLEI 226
T QK E ++ L +L+E +HQ+ L ++ S+++ L
Sbjct: 2141 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2200
Query: 227 SKIIMSSVSNLK 238
++ M +S LK
Sbjct: 2201 VRVQMEELSKLK 2212
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 55.1 bits (131), Expect = 1e-07
Identities = 52/235 (22%), Positives = 116/235 (49%), Gaps = 21/235 (8%)
Query: 40 EVTSPKILHSPNSQALILALKTLQEKIHRLELERTQ--AED--NLNILSREAAQYKKALE 95
E++ K ++ALIL K ++ + E E+ + AE+ L++ ++EAA+ ++ E
Sbjct: 2376 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2435
Query: 96 NETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQA 155
+ ++ ++++K+K + + ++ LL++Q E + ++ +K + +Q A
Sbjct: 2436 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2495
Query: 156 Q----LQREKE---QDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEH 208
+ QR E Q Q+++ A+ E+L + E R + + + E++ E+ H
Sbjct: 2496 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2555
Query: 209 QRKL-FQDKASELQTGLEI--------SKIIMSSVSNLKHSKEKKKSSKKTKCIK 254
+ +L Q+K + +QT LEI ++ + +++ L+ KEK + K +K
Sbjct: 2556 RTELATQEKVTLVQT-LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2609
Score = 50.4 bits (119), Expect = 3e-06
Identities = 50/172 (29%), Positives = 86/172 (50%), Gaps = 12/172 (6%)
Query: 52 SQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQ 111
++AL L L+ +E + L + +AE REA + KA E +R LA QEL KQ
Sbjct: 1776 NEALRLRLQA-EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1834
Query: 112 KKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQRE---KEQDQMKL 168
++ + +AQ R E++L + E+++ ++ E+ A+LQRE Q + +L
Sbjct: 1835 RQ---LAEGTAQQRLAA-EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1890
Query: 169 YAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEE-EHQRKLFQDKASE 219
A+L K + E L ++ AE++ + EK K+ E + F++ A E
Sbjct: 1891 EAELAK---VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1939
Score = 42.4 bits (98), Expect = 9e-04
Identities = 44/197 (22%), Positives = 86/197 (43%), Gaps = 9/197 (4%)
Query: 60 KTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIK---QKKDIS 116
++LQE+ + R +AE EA + ++ E E L E ++ Q ++++
Sbjct: 1731 RSLQEEHVAVAQLREEAERRAQ-QQAEAERAREEAERELERWQLKANEALRLRLQAEEVA 1789
Query: 117 IQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLD 176
Q S AQ+ EKQ E +R + + + Q+ ++E E+ + ++
Sbjct: 1790 QQKSLAQAEA---EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1846
Query: 177 VLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSV-- 234
E+E RL + E + + LEE+L + + K EL+ L + M +
Sbjct: 1847 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1906
Query: 235 SNLKHSKEKKKSSKKTK 251
S + +E + +S+K+K
Sbjct: 1907 SKARAEEESRSTSEKSK 1923
Score = 40.4 bits (93), Expect = 0.003
Identities = 42/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)
Query: 64 EKIHRLEL---ERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLS 120
EK+HR EL E+ L I +++ + L E ++L ++ K +QL
Sbjct: 2552 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK--LLQLK 2609
Query: 121 SAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREK---EQDQMKLYAKLEKL-- 175
S + + E+ L+ T+ + + EK+ +L+++ +++EK EQ AK ++L
Sbjct: 2610 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2669
Query: 176 ------DVLEKECFRLTTT-------QKTAEDKIKHLEEKLKEEEHQRKLFQDKASE 219
+E+E RL + Q AE+ ++ +E+L++ E QR+ ++ +E
Sbjct: 2670 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2726
Score = 38.5 bits (88), Expect = 0.013
Identities = 36/182 (19%), Positives = 83/182 (45%), Gaps = 5/182 (2%)
Query: 62 LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSS 121
L+E++ RL+ E A L E A+ + +E + A +E + +L +
Sbjct: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1928
Query: 122 AQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKE 181
R L ++ + + +R++ + E A+ + E E+ + A + + L+ E
Sbjct: 1929 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1988
Query: 182 CFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLE--ISKIIMSSVSNLKH 239
+ +K AE+ + L ++E QR+ +++A++ + +E ++++ +S S L+
Sbjct: 1989 A-EIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 2045
Query: 240 SK 241
K
Sbjct: 2046 QK 2047
Score = 37.0 bits (84), Expect = 0.038
Identities = 55/195 (28%), Positives = 87/195 (44%), Gaps = 22/195 (11%)
Query: 29 EPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAA 88
+ SQ A +E+ S + ++ AL+ L+E L L+ +AE L E A
Sbjct: 1642 DESQRKRQAEVELASRVKAEAEAAREKQRALQALEE----LRLQAEEAERRLRQAEVERA 1697
Query: 89 -QYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREK 147
Q + ALE T +R+ A EL Q K S +AQ LE+ L+ V + E
Sbjct: 1698 RQVQVALE--TAQRS-AEAEL--QSKRASFAEKTAQ-----LERSLQEEHVAVAQLREEA 1747
Query: 148 NMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRL-TTTQKTAEDK--IKHLEEKLK 204
+QQA+ +R +E+ + +LE+ + E RL ++ A+ K + EK K
Sbjct: 1748 ERRAQQQAEAERAREEAE----RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1803
Query: 205 EEEHQRKLFQDKASE 219
EE + + KA E
Sbjct: 1804 EEAEREARRRGKAEE 1818
Score = 32.3 bits (72), Expect = 0.93
Identities = 40/192 (20%), Positives = 79/192 (41%), Gaps = 20/192 (10%)
Query: 62 LQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSS 121
+Q+K L+ Q + L+ L EA ++A E R A +E + ++ Q+
Sbjct: 2195 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR----QVEE 2250
Query: 122 AQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKE 181
A+ E+Q + + E+ + EQ+A + + EQ ++ + K+
Sbjct: 2251 AERLKQSAEEQAQARAQAQAAAEKLRKEA-EQEAARRAQAEQAALRQKQAADAEMEKHKK 2309
Query: 182 CFRLTTTQKT-AEDKIKHLEEKLKEEEHQRKLFQDKA--------------SELQTGLEI 226
T QK E ++ L +L+E +HQ+ L ++ S+++ L
Sbjct: 2310 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2369
Query: 227 SKIIMSSVSNLK 238
++ M +S LK
Sbjct: 2370 VRVQMEELSKLK 2381
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.126 0.352
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,590,059
Number of Sequences: 37866
Number of extensions: 818501
Number of successful extensions: 8526
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 263
Number of HSP's successfully gapped in prelim test: 748
Number of HSP's that attempted gapping in prelim test: 4320
Number of HSP's gapped (non-prelim): 3165
length of query: 460
length of database: 18,247,518
effective HSP length: 106
effective length of query: 354
effective length of database: 14,233,722
effective search space: 5038737588
effective search space used: 5038737588
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.