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Search of human proteins with 55925604
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55925604 kelch-like 18 [Homo sapiens]
(574 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55925604 kelch-like 18 [Homo sapiens] 1176 0.0
gi|38194229 kelch-like 17 [Homo sapiens] 472 e-133
gi|40807500 kelch-like 20 [Homo sapiens] 459 e-129
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 435 e-122
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 435 e-122
gi|14780904 kelch-like 1 protein [Homo sapiens] 429 e-120
gi|11056006 kelch-like 12 [Homo sapiens] 424 e-119
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 423 e-118
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 423 e-118
gi|166235129 kelch-like 3 [Homo sapiens] 416 e-116
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 413 e-115
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 397 e-110
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 395 e-110
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 391 e-109
gi|34101268 kelch-like 8 [Homo sapiens] 380 e-105
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 368 e-102
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 343 3e-94
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 343 3e-94
gi|148664209 kelch-like 10 [Homo sapiens] 316 3e-86
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 311 8e-85
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 301 1e-81
gi|223890235 intracisternal A particle-promoted polypeptide isof... 294 2e-79
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 291 1e-78
gi|40018614 DRE1 protein [Homo sapiens] 278 7e-75
gi|45643138 kelch-like 13 [Homo sapiens] 270 2e-72
gi|24308181 kelch-like 9 [Homo sapiens] 267 2e-71
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 265 7e-71
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 265 7e-71
gi|109150407 kelch-like 6 [Homo sapiens] 261 1e-69
gi|55925608 kelch-like 21 [Homo sapiens] 252 6e-67
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 1176 bits (3043), Expect = 0.0
Identities = 574/574 (100%), Positives = 574/574 (100%)
Query: 1 MVEDGAEELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASI 60
MVEDGAEELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASI
Sbjct: 1 MVEDGAEELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASI 60
Query: 61 PYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQL 120
PYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQL
Sbjct: 61 PYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQL 120
Query: 121 QSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALP 180
QSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALP
Sbjct: 121 QSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALP 180
Query: 181 LEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDR 240
LEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDR
Sbjct: 181 LEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDR 240
Query: 241 VQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAG 300
VQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAG
Sbjct: 241 VQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAG 300
Query: 301 DSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPET 360
DSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPET
Sbjct: 301 DSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPET 360
Query: 361 DTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNR 420
DTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNR
Sbjct: 361 DTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNR 420
Query: 421 SAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMF 480
SAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMF
Sbjct: 421 SAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMF 480
Query: 481 VCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSS 540
VCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSS
Sbjct: 481 VCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSS 540
Query: 541 VEMYDPETDCWTFMAPMACHEGGVGVGCIPLLTI 574
VEMYDPETDCWTFMAPMACHEGGVGVGCIPLLTI
Sbjct: 541 VEMYDPETDCWTFMAPMACHEGGVGVGCIPLLTI 574
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 472 bits (1214), Expect = e-133
Identities = 248/573 (43%), Positives = 340/573 (59%), Gaps = 5/573 (0%)
Query: 4 DGAEELEDLVHFSVSELPSRGYG----VMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAAS 59
+GA +L SV+ R Y M +R++G LCD+ L + + AH++VLA+
Sbjct: 54 EGAVQLLSREGHSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASC 113
Query: 60 IPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQ 119
PYFHAMFTN+M E +Q + + +DP AL+ L+ FAY + + + NVQ+LL AS LQ
Sbjct: 114 SPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQ 173
Query: 120 LQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLAL 179
L ++DACC FL +L P NCLG+R FA+ C+ L AA+ ++ QHFV+V+ +EEF+ L
Sbjct: 174 LNGVRDACCKFLLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLL 233
Query: 180 PLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSD 239
PL+ VLELVS D LNV SEE+V+ A L+WV++D + R ++P L+ +RLPL FL
Sbjct: 234 PLKQVLELVSSDSLNVPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLG 293
Query: 240 RVQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSA 299
V + LVR C+DL+ EA +HL+PE+R L RTRPR C +++AVGG S
Sbjct: 294 HVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGG-GSL 352
Query: 300 GDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPE 359
E +D + W M+T R+RVGVA V LYA+GGYDG L+TVE+Y+P
Sbjct: 353 FAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPV 412
Query: 360 TDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSN 419
T+TW SM ++RS +G L G +Y GGYDG S L+S E Y P T WT V +MS+
Sbjct: 413 TNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTR 472
Query: 420 RSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKM 479
R V +G +Y GG+D ++VE Y W P A ML++R G A L +
Sbjct: 473 RRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGAL 532
Query: 480 FVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLS 539
+V GG DG+ L+ E YS A W + PM+ RRS LVA G LYAVGG DG S+L+
Sbjct: 533 YVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLN 592
Query: 540 SVEMYDPETDCWTFMAPMACHEGGVGVGCIPLL 572
S+E Y+P T+ W + M VGV + LL
Sbjct: 593 SIEKYNPRTNKWVAASCMFTRRSSVGVAVLELL 625
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 459 bits (1181), Expect = e-129
Identities = 237/552 (42%), Positives = 341/552 (61%), Gaps = 2/552 (0%)
Query: 21 PSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIV 80
P + V+ +R+ +LCDV L +G K AHR++L+A PYF AMFT ++ E +Q E+V
Sbjct: 51 PRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVV 110
Query: 81 MQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNC 140
++ +D A+E LI+FAY + +++ NVQ+LL A LQL I++ACC FL+ +L P NC
Sbjct: 111 IRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNC 170
Query: 141 LGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQ 200
LG+R FA+T C L A+ F +F EV SEEF+ LP +++++S DELNV+SEEQ
Sbjct: 171 LGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQ 230
Query: 201 VFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEA 260
VF A +AWV+Y ++R P LP++L ++RLPL P+FL V D L++ +CRDLVDEA
Sbjct: 231 VFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEA 290
Query: 261 KDYHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCR 320
K+Y L+P+ RP + RTRPR +++AVGG S GD+++ VE +DP N W
Sbjct: 291 KNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCS-GDAISSVERYDPQTNEWRMVA 349
Query: 321 PMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTR-VGSMNSKRSAMGTV 379
M+ R VGV+V++ LLYA+GG+DG L++VE Y+P+T+ W+ V ++ R+++G
Sbjct: 350 SMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVA 409
Query: 380 VLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHD 439
VL G +Y GG DG S L+ VE Y P+ +KWT V SMS+ R V V G +Y GG D
Sbjct: 410 VLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSD 469
Query: 440 GLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSS 499
G ++VE YN WH A M +R G A ++ GG D + LS AE Y+
Sbjct: 470 GTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNP 529
Query: 500 VADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMAC 559
+QW +V M +RRS V L G+L AVGG+DG + L ++E++DP+ + W M
Sbjct: 530 RTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNY 589
Query: 560 HEGGVGVGCIPL 571
G GVG I +
Sbjct: 590 RRLGGGVGVIKM 601
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 435 bits (1118), Expect = e-122
Identities = 225/550 (40%), Positives = 331/550 (60%), Gaps = 10/550 (1%)
Query: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS 87
ME R +LCDV L GD + AHR+VL++ YF AMFTND+ E +Q+EI M+G++P+
Sbjct: 164 MENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPN 223
Query: 88 ALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFA 147
+L +LI +AY G L + + N++ LL A LQL + +ACC FL ++LHP NCLG+R FA
Sbjct: 224 SLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFA 283
Query: 148 ETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALA 207
+ C L+ A+++ +HF+EV ++EF+ LP ++ +L++ D++N+ +EE + A L
Sbjct: 284 DAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLT 343
Query: 208 WVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMP 267
WVR+D EQR L +LL+ IRLPL PQFL+D ++ + L R +C+ L+ EA YHL+P
Sbjct: 344 WVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLP 402
Query: 268 ERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARS 327
ERRP L + RT+PR S G ++AVGG++S + + +E +D N W M R
Sbjct: 403 ERRPMLQSPRTKPR--KSTVGTLFAVGGMDSTKGATS-IEKYDLRTNMWTPVANMNGRRL 459
Query: 328 RVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYV 387
+ GVAV++ LY +GG DG L+TVE YNP+T TW+ + M++ R +G VL+G +Y
Sbjct: 460 QFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYA 519
Query: 388 CGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSV 447
GG+DG S L++VE + P+ +W V +MS+ RS GV V G++Y GG DG SV
Sbjct: 520 VGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSV 579
Query: 448 EHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDG------SGFLSIAEMYSSVA 501
E ++ HT W A M +R G + ++ GG+D S E Y
Sbjct: 580 ECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKT 639
Query: 502 DQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACHE 561
D W + M R V + +LYAVGGYDGQ+ L++VE YDP+T+ WT +AP+
Sbjct: 640 DMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGR 699
Query: 562 GGVGVGCIPL 571
G V + L
Sbjct: 700 AGACVVTVKL 709
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 435 bits (1118), Expect = e-122
Identities = 225/550 (40%), Positives = 331/550 (60%), Gaps = 10/550 (1%)
Query: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS 87
ME R +LCDV L GD + AHR+VL++ YF AMFTND+ E +Q+EI M+G++P+
Sbjct: 210 MENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPN 269
Query: 88 ALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFA 147
+L +LI +AY G L + + N++ LL A LQL + +ACC FL ++LHP NCLG+R FA
Sbjct: 270 SLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFA 329
Query: 148 ETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALA 207
+ C L+ A+++ +HF+EV ++EF+ LP ++ +L++ D++N+ +EE + A L
Sbjct: 330 DAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLT 389
Query: 208 WVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMP 267
WVR+D EQR L +LL+ IRLPL PQFL+D ++ + L R +C+ L+ EA YHL+P
Sbjct: 390 WVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLP 448
Query: 268 ERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARS 327
ERRP L + RT+PR S G ++AVGG++S + + +E +D N W M R
Sbjct: 449 ERRPMLQSPRTKPR--KSTVGTLFAVGGMDSTKGATS-IEKYDLRTNMWTPVANMNGRRL 505
Query: 328 RVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYV 387
+ GVAV++ LY +GG DG L+TVE YNP+T TW+ + M++ R +G VL+G +Y
Sbjct: 506 QFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYA 565
Query: 388 CGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSV 447
GG+DG S L++VE + P+ +W V +MS+ RS GV V G++Y GG DG SV
Sbjct: 566 VGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSV 625
Query: 448 EHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDG------SGFLSIAEMYSSVA 501
E ++ HT W A M +R G + ++ GG+D S E Y
Sbjct: 626 ECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKT 685
Query: 502 DQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACHE 561
D W + M R V + +LYAVGGYDGQ+ L++VE YDP+T+ WT +AP+
Sbjct: 686 DMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGR 745
Query: 562 GGVGVGCIPL 571
G V + L
Sbjct: 746 AGACVVTVKL 755
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 429 bits (1103), Expect = e-120
Identities = 230/567 (40%), Positives = 335/567 (59%), Gaps = 15/567 (2%)
Query: 6 AEELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHA 65
+EE VH + + + ME +Q +LCDV L +G+ K AHR+VL++ YF A
Sbjct: 185 SEEFYQAVHHA-----EQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAA 239
Query: 66 MFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKD 125
MFT+D+ E KQ+EI M+G+DP+AL L+ FAY G L + + +++LL A LQL + +
Sbjct: 240 MFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVE 299
Query: 126 ACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVL 185
CC FL + LHP NCLG+R FA+ C L A+S+ ++ +EV ++EFL LP E++
Sbjct: 300 VCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELH 359
Query: 186 ELVSRDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDD 245
+L++ D++NV EE +F A + WV+YD + R L LL+ IRLPL PQ L+D ++
Sbjct: 360 KLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHA 418
Query: 246 LVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNV 305
L + +C+ L+ EA YHL+PERR + + RT+PR S G +YAVGG+++
Sbjct: 419 LFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPR--KSTVGTLYAVGGMDN-NKGATT 475
Query: 306 VEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTR 365
+E +D N W + M R + GVAV++ L+ IGG DG L+TVE YNP+T TWT
Sbjct: 476 IEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTV 535
Query: 366 VGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGV 425
+ M++ R +G VL+G IY GG+DG S L++VE + P++ +WT V SMS RS GV
Sbjct: 536 LPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGV 595
Query: 426 TVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGY 485
G++Y GG DG SS+E+Y+ HT W+ A M +R G A+ ++ GG+
Sbjct: 596 AALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGH 655
Query: 486 DG------SGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLS 539
D S L E Y D W ++ P+ R V + RLYAVGGYDGQ+ L+
Sbjct: 656 DAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLN 715
Query: 540 SVEMYDPETDCWTFMAPMACHEGGVGV 566
++E YDP+T+ WT MA + G V
Sbjct: 716 TMESYDPQTNEWTQMASLNIGRAGACV 742
Score = 121 bits (304), Expect = 2e-27
Identities = 59/151 (39%), Positives = 92/151 (60%), Gaps = 7/151 (4%)
Query: 285 SIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGY 344
++ G +Y+VGG + + L+ +E +DP N W C PM R VGVA +G LYA+GG+
Sbjct: 597 ALNGKLYSVGGRDGSS-CLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGH 655
Query: 345 DGQLR------LSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLS 398
D L VE Y+P+TDTWT V ++ R A+G +L ++Y GGYDG + L+
Sbjct: 656 DAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLN 715
Query: 399 SVETYSPETDKWTVVTSMSSNRSAAGVTVFE 429
++E+Y P+T++WT + S++ R+ A V V +
Sbjct: 716 TMESYDPQTNEWTQMASLNIGRAGACVVVIK 746
Score = 100 bits (248), Expect = 5e-21
Identities = 51/140 (36%), Positives = 77/140 (55%)
Query: 430 GRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSG 489
G +Y GG D + +++E Y+ T W A M +R + G A + K+FV GG DG
Sbjct: 459 GTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLK 518
Query: 490 FLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETD 549
L+ E Y+ W ++ PM T R + + G +YAVGG+DG S L++VE +DP++
Sbjct: 519 TLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQ 578
Query: 550 CWTFMAPMACHEGGVGVGCI 569
WTF+A M+ VGV +
Sbjct: 579 QWTFVASMSIARSTVGVAAL 598
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 424 bits (1091), Expect = e-119
Identities = 224/542 (41%), Positives = 305/542 (56%), Gaps = 5/542 (0%)
Query: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS 87
M +R+ LCDVTL++ F AHRIVLAA YF AMFT+++ E + + +QG+ S
Sbjct: 23 MNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLTAS 82
Query: 88 ALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFA 147
+E L++F Y + + +NVQ LL A LQL+ +K ACC FL +L P NCLG+R FA
Sbjct: 83 TMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFA 142
Query: 148 ETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALA 207
ET C L AA F +HF EV EEF+ L +V +L+ DE+ V SEE VFEA +
Sbjct: 143 ETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVIN 202
Query: 208 WVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMP 267
WV++ +++R LP LL +R+PL P++++D + + +RC +CRDLVDEAK +HL P
Sbjct: 203 WVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHLRP 262
Query: 268 ERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARS 327
E R + RTR R + ++ VGG S ++VVE +DP W +T R
Sbjct: 263 ELRSQMQGPRTRARLGAN--EVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRR 320
Query: 328 RVGVAVVNGLLYAIGGYDGQLRLSTVEAYN---PETDTWTRVGSMNSKRSAMGTVVLDGQ 384
V ++ +Y IGGYDG+ RLS+VE + E W V MN +R G L
Sbjct: 321 YVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDM 380
Query: 385 IYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIF 444
IYV GG+DG+ +S+E Y P D+W+++ M + R AG+ V G IY GG+DGL I
Sbjct: 381 IYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNIL 440
Query: 445 SSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQW 504
+SVE Y+ HT W M KR G A L ++V GG+DG+ LS E Y+ D W
Sbjct: 441 NSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSW 500
Query: 505 CLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACHEGGV 564
+ M T R V GRLYA+ GYDG S LSS+E YDP D W + M
Sbjct: 501 TTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDA 560
Query: 565 GV 566
GV
Sbjct: 561 GV 562
Score = 155 bits (391), Expect = 1e-37
Identities = 79/195 (40%), Positives = 111/195 (56%), Gaps = 1/195 (0%)
Query: 284 TSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGG 343
T++ +IY GG + + ++ E +DP + W M TAR G+ V +G++Y +GG
Sbjct: 375 TTLGDMIYVSGGFDGSRRHTSM-ERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGG 433
Query: 344 YDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETY 403
YDG L++VE Y+P T WT V M +KRS G +L+ IYV GG+DG + LSSVE Y
Sbjct: 434 YDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAY 493
Query: 404 SPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGM 463
+ TD WT VTSM++ R G TV GR+Y G+DG + SS+E Y+ +W M
Sbjct: 494 NIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSM 553
Query: 464 LNKRCRHGAASLGSK 478
+RC G L K
Sbjct: 554 GTQRCDAGVCVLREK 568
Score = 129 bits (323), Expect = 1e-29
Identities = 71/189 (37%), Positives = 99/189 (52%), Gaps = 4/189 (2%)
Query: 385 IYVCGGYDGNSS-LSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQI 443
+ V GG+ S + VE Y P+T +W+ + S++ R RIYV GG+DG
Sbjct: 283 LLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSR 342
Query: 444 FSSVEHYNH---HTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSV 500
SSVE ++ W+ A M +R GA +LG ++V GG+DGS + E Y
Sbjct: 343 LSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPN 402
Query: 501 ADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACH 560
DQW ++ M T R LV + G +Y +GGYDG + L+SVE YDP T WT + PMA
Sbjct: 403 IDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATK 462
Query: 561 EGGVGVGCI 569
G GV +
Sbjct: 463 RSGAGVALL 471
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 423 bits (1088), Expect = e-118
Identities = 217/536 (40%), Positives = 323/536 (60%), Gaps = 5/536 (0%)
Query: 23 RGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQ 82
+ + VM E+R Q LCDVT+ D + SAHR+VLAA PYFHAMFT +M E + + ++
Sbjct: 45 KAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIK 104
Query: 83 GMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLG 142
+D L LI++ Y + + ++NVQ LL A LQLQ +K CC FL +LHP NCLG
Sbjct: 105 EVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLG 164
Query: 143 VRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVF 202
+R FA+ C L + AN++ QHF +V +SEEFL L +E V L+S D+L + SEE+VF
Sbjct: 165 IRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVF 224
Query: 203 EAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKD 262
EA +AWV +D++ R ++ L+ ++RLPL ++L RV+++ LV+ C+D + EA
Sbjct: 225 EAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMK 284
Query: 263 YHLMP-ERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRP 321
YHL+P E+R + + RTR R ++ L+ VGG A ++ VE +D W +
Sbjct: 285 YHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG--QAPKAIRSVECYDFKEERWHQVAE 342
Query: 322 MTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVL 381
+ + R R G+ + GL++A+GG++G LR+ TV++Y+P D WT V +M +RS +G VL
Sbjct: 343 LPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVL 402
Query: 382 DGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGL 441
+G +Y GG+DG++ LSSVE Y+ ++++W V M++ RS+ GV V G +Y GG+DG
Sbjct: 403 NGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGA 462
Query: 442 --QIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSS 499
Q S+VE YN T W A M +R G L + ++ GG+DG E+Y
Sbjct: 463 SRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDP 522
Query: 500 VADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMA 555
+ W + M+ R + A G LY VGG DG NL+SVE Y+P TD WT ++
Sbjct: 523 TTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVS 578
Score = 136 bits (342), Expect = 6e-32
Identities = 71/146 (48%), Positives = 95/146 (65%), Gaps = 2/146 (1%)
Query: 286 IAGLIYAVGGLNSAG-DSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGY 344
+ GL+YAVGG + A L+ VE ++ N W M+T RS GV V+N LLYA+GG+
Sbjct: 449 VGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGH 508
Query: 345 DGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYS 404
DG L +VE Y+P T+ W +V MN R G ++G +YV GG DG+ +L+SVE Y+
Sbjct: 509 DGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 568
Query: 405 PETDKWTVVTS-MSSNRSAAGVTVFE 429
P TDKWTVV+S MS+ RS AGVTV +
Sbjct: 569 PTTDKWTVVSSCMSTGRSYAGVTVID 594
Score = 127 bits (318), Expect = 4e-29
Identities = 72/203 (35%), Positives = 109/203 (53%), Gaps = 2/203 (0%)
Query: 369 MNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVF 428
M S R+ + T + ++ V G ++ SVE Y + ++W V + S R AG+
Sbjct: 296 MKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYM 355
Query: 429 EGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGS 488
G ++ GG +G +V+ Y+ W A M ++R GAA L ++ GG+DGS
Sbjct: 356 AGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGS 415
Query: 489 GFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSN--LSSVEMYDP 546
LS E Y+ +++W + PM+TRRS V + G LYAVGGYDG S LS+VE Y+
Sbjct: 416 TGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNA 475
Query: 547 ETDCWTFMAPMACHEGGVGVGCI 569
T+ WT++A M+ G GVG +
Sbjct: 476 TTNEWTYIAEMSTRRSGAGVGVL 498
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 423 bits (1088), Expect = e-118
Identities = 217/536 (40%), Positives = 323/536 (60%), Gaps = 5/536 (0%)
Query: 23 RGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQ 82
+ + VM E+R Q LCDVT+ D + SAHR+VLAA PYFHAMFT +M E + + ++
Sbjct: 41 KAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIK 100
Query: 83 GMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLG 142
+D L LI++ Y + + ++NVQ LL A LQLQ +K CC FL +LHP NCLG
Sbjct: 101 EVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLG 160
Query: 143 VRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVF 202
+R FA+ C L + AN++ QHF +V +SEEFL L +E V L+S D+L + SEE+VF
Sbjct: 161 IRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVF 220
Query: 203 EAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKD 262
EA +AWV +D++ R ++ L+ ++RLPL ++L RV+++ LV+ C+D + EA
Sbjct: 221 EAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMK 280
Query: 263 YHLMP-ERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRP 321
YHL+P E+R + + RTR R ++ L+ VGG A ++ VE +D W +
Sbjct: 281 YHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG--QAPKAIRSVECYDFKEERWHQVAE 338
Query: 322 MTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVL 381
+ + R R G+ + GL++A+GG++G LR+ TV++Y+P D WT V +M +RS +G VL
Sbjct: 339 LPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVL 398
Query: 382 DGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGL 441
+G +Y GG+DG++ LSSVE Y+ ++++W V M++ RS+ GV V G +Y GG+DG
Sbjct: 399 NGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGA 458
Query: 442 --QIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSS 499
Q S+VE YN T W A M +R G L + ++ GG+DG E+Y
Sbjct: 459 SRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDP 518
Query: 500 VADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMA 555
+ W + M+ R + A G LY VGG DG NL+SVE Y+P TD WT ++
Sbjct: 519 TTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVS 574
Score = 136 bits (342), Expect = 6e-32
Identities = 71/146 (48%), Positives = 95/146 (65%), Gaps = 2/146 (1%)
Query: 286 IAGLIYAVGGLNSAG-DSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGY 344
+ GL+YAVGG + A L+ VE ++ N W M+T RS GV V+N LLYA+GG+
Sbjct: 445 VGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGH 504
Query: 345 DGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYS 404
DG L +VE Y+P T+ W +V MN R G ++G +YV GG DG+ +L+SVE Y+
Sbjct: 505 DGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 564
Query: 405 PETDKWTVVTS-MSSNRSAAGVTVFE 429
P TDKWTVV+S MS+ RS AGVTV +
Sbjct: 565 PTTDKWTVVSSCMSTGRSYAGVTVID 590
Score = 127 bits (318), Expect = 4e-29
Identities = 72/203 (35%), Positives = 109/203 (53%), Gaps = 2/203 (0%)
Query: 369 MNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVF 428
M S R+ + T + ++ V G ++ SVE Y + ++W V + S R AG+
Sbjct: 292 MKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYM 351
Query: 429 EGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGS 488
G ++ GG +G +V+ Y+ W A M ++R GAA L ++ GG+DGS
Sbjct: 352 AGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGS 411
Query: 489 GFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSN--LSSVEMYDP 546
LS E Y+ +++W + PM+TRRS V + G LYAVGGYDG S LS+VE Y+
Sbjct: 412 TGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNA 471
Query: 547 ETDCWTFMAPMACHEGGVGVGCI 569
T+ WT++A M+ G GVG +
Sbjct: 472 TTNEWTYIAEMSTRRSGAGVGVL 494
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 416 bits (1070), Expect = e-116
Identities = 213/535 (39%), Positives = 320/535 (59%), Gaps = 5/535 (0%)
Query: 23 RGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQ 82
+ + VM E+R + LCDV + D + AHR+VLAA PYF AMFT DM E K +I ++
Sbjct: 35 KAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIK 94
Query: 83 GMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLG 142
+D L LI++ Y + + ++NVQ LL AS LQL ++ CC FL+ +LHP NCLG
Sbjct: 95 DVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLG 154
Query: 143 VRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVF 202
+R FA+ C L AN++ QHF EV + EEFL+L L+ V L+S D+L V SEE+VF
Sbjct: 155 IRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVF 214
Query: 203 EAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKD 262
EA ++W+ Y++E R ++ +L+ ++RLPL +L V+++ L++ + C+D + EA
Sbjct: 215 EAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMK 274
Query: 263 YHLMP-ERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRP 321
YHL+P ++R + RT+PR S+ ++ VGG A ++ VE +D + W++
Sbjct: 275 YHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGG--QAPKAIRSVECYDFEEDRWDQIAE 332
Query: 322 MTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVL 381
+ + R R GV + G +YA+GG++G LR+ TV+ Y+ D WT + SM +RS +G VL
Sbjct: 333 LPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVL 392
Query: 382 DGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGL 441
+ +Y GG+DG++ L+SVE YS +T++W V M++ RS+ GV V EG++Y GG+DG
Sbjct: 393 NDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGA 452
Query: 442 --QIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSS 499
Q S+VE YN T W A M +R G L +++ GG+DG E+Y
Sbjct: 453 SRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDP 512
Query: 500 VADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFM 554
+ W + M+ R + A G LY VGG DG NL+SVE Y+P TD WT +
Sbjct: 513 GTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLL 567
Score = 132 bits (333), Expect = 7e-31
Identities = 73/203 (35%), Positives = 107/203 (52%), Gaps = 2/203 (0%)
Query: 369 MNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVF 428
+ + R+ T V ++ + G ++ SVE Y E D+W + + S R AGV
Sbjct: 286 IKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFM 345
Query: 429 EGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGS 488
G +Y GG +G +V+ Y+ W A M +R GAA L ++ GG+DGS
Sbjct: 346 AGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGS 405
Query: 489 GFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSN--LSSVEMYDP 546
L+ E YS ++W + PM+TRRS V + G+LYAVGGYDG S LS+VE Y+P
Sbjct: 406 TGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNP 465
Query: 547 ETDCWTFMAPMACHEGGVGVGCI 569
T+ W ++A M+ G GVG +
Sbjct: 466 ATNEWIYVADMSTRRSGAGVGVL 488
Score = 128 bits (322), Expect = 1e-29
Identities = 68/144 (47%), Positives = 93/144 (64%), Gaps = 2/144 (1%)
Query: 286 IAGLIYAVGGLNSAG-DSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGY 344
+ G +YAVGG + A L+ VE ++P N W M+T RS GV V++G LYA GG+
Sbjct: 439 VEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGH 498
Query: 345 DGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYS 404
DG L +VE Y+P T+TW +V MN R G ++G +YV GG DG+ +L+SVE Y+
Sbjct: 499 DGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 558
Query: 405 PETDKWTVV-TSMSSNRSAAGVTV 427
P TDKWT++ T+MS+ RS AGV V
Sbjct: 559 PVTDKWTLLPTNMSTGRSYAGVAV 582
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 413 bits (1061), Expect = e-115
Identities = 214/528 (40%), Positives = 319/528 (60%), Gaps = 10/528 (1%)
Query: 50 SAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQ 109
S+ R+VL++ YF AMFTND+ E +Q+EI M+G++P++L +LI +AY G L + + N++
Sbjct: 171 SSCRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIE 230
Query: 110 SLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVE 169
LL A LQL + +ACC FL ++LHP NCLG+R FA+ C L+ A+++ +HF+E
Sbjct: 231 CLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFME 290
Query: 170 VSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRL 229
V ++EF+ LP ++ +L++ D++N+ +EE + A L WVR+D EQR L +LL+ IRL
Sbjct: 291 VIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRL 350
Query: 230 PLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIAGL 289
PL PQFL+D ++ + L R +C+ L+ EA YHL+PERRP L + RT+PR S G
Sbjct: 351 PLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPR--KSTVGT 407
Query: 290 IYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLR 349
++AVGG++S + + +E +D N W M R + GVAV++ LY +GG DG
Sbjct: 408 LFAVGGMDSTKGATS-IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKT 466
Query: 350 LSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDK 409
L+TVE YNP+T TW+ + M++ R +G VL+G +Y GG+DG S L++VE + P+ +
Sbjct: 467 LNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQ 526
Query: 410 WTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCR 469
W V +MS+ RS GV V G++Y GG DG SVE ++ HT W A M +R
Sbjct: 527 WNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGG 586
Query: 470 HGAASLGSKMFVCGGYDG------SGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASC 523
G + ++ GG+D S E Y D W + M R V +
Sbjct: 587 VGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLG 646
Query: 524 GRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACHEGGVGVGCIPL 571
+LYAVGGYDGQ+ L++VE YDP+T+ WT +AP+ G V + L
Sbjct: 647 DKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 694
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 397 bits (1020), Expect = e-110
Identities = 211/550 (38%), Positives = 310/550 (56%), Gaps = 10/550 (1%)
Query: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS 87
ME ++ +LCDV L G + AHR+VL+A YF AMFTND++E KQ+E+ M+G+DP+
Sbjct: 172 MENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPN 231
Query: 88 ALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFA 147
AL +L+ +AY G L + + ++SLL A LQL + D C FL ++LHP NCLG+R F
Sbjct: 232 ALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFG 291
Query: 148 ETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALA 207
+ C L + A+ + +HF+EV ++EFL LP ++ +L+ D++NV EE +F A +
Sbjct: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQ 351
Query: 208 WVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMP 267
WV +D + R L LLS IRLPL PQ L+D ++ + +C+ L+ EA YHL+P
Sbjct: 352 WVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLMEAMKYHLLP 410
Query: 268 ERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARS 327
ERR + + RT+PR S G +YAVGG++ A +E +D N W M R
Sbjct: 411 ERRSMMQSPRTKPR--KSTVGALYAVGGMD-AMKGTTTIEKYDLRTNSWLHIGTMNGRRL 467
Query: 328 RVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYV 387
+ GVAV++ LY +GG DG L+TVE +NP WT + M++ R +G L+G +Y
Sbjct: 468 QFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYA 527
Query: 388 CGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSV 447
GG+DG S L++VE + PE +W V SMS+ RS GV ++Y GG DG S+
Sbjct: 528 VGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSM 587
Query: 448 EHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDG------SGFLSIAEMYSSVA 501
E+++ HT W A M +R G A+ ++V GG+D S E Y
Sbjct: 588 EYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKG 647
Query: 502 DQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACHE 561
D W + P+ R V++ +LY VGGYDG + L++VE YD + + W P+
Sbjct: 648 DSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGR 707
Query: 562 GGVGVGCIPL 571
G V + L
Sbjct: 708 AGACVVVVKL 717
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 395 bits (1014), Expect = e-110
Identities = 207/530 (39%), Positives = 304/530 (57%), Gaps = 10/530 (1%)
Query: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS 87
ME ++ +LCDV L G + AHR+VL+A YF AMFTND++E KQ+E+ M+G+DP+
Sbjct: 172 MENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPN 231
Query: 88 ALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFA 147
AL +L+ +AY G L + + ++SLL A LQL + D C FL ++LHP NCLG+R F
Sbjct: 232 ALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFG 291
Query: 148 ETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALA 207
+ C L + A+ + +HF+EV ++EFL LP ++ +L+ D++NV EE +F A +
Sbjct: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQ 351
Query: 208 WVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMP 267
WV +D + R L LLS IRLPL PQ L+D ++ + +C+ L+ EA YHL+P
Sbjct: 352 WVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLECQKLLMEAMKYHLLP 410
Query: 268 ERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARS 327
ERR + + RT+PR S G +YAVGG++ A +E +D N W M R
Sbjct: 411 ERRSMMQSPRTKPR--KSTVGALYAVGGMD-AMKGTTTIEKYDLRTNSWLHIGTMNGRRL 467
Query: 328 RVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYV 387
+ GVAV++ LY +GG DG L+TVE +NP WT + M++ R +G L+G +Y
Sbjct: 468 QFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYA 527
Query: 388 CGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSV 447
GG+DG S L++VE + PE +W V SMS+ RS GV ++Y GG DG S+
Sbjct: 528 VGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSM 587
Query: 448 EHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDG------SGFLSIAEMYSSVA 501
E+++ HT W A M +R G A+ ++V GG+D S E Y
Sbjct: 588 EYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKG 647
Query: 502 DQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCW 551
D W + P+ R V++ +LY VGGYDG + L++VE YD + + W
Sbjct: 648 DSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEW 697
Score = 135 bits (341), Expect = 8e-32
Identities = 69/184 (37%), Positives = 99/184 (53%)
Query: 383 GQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQ 442
G +Y GG D +++E Y T+ W + +M+ R GV V + ++YV GG DGL+
Sbjct: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK 488
Query: 443 IFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVAD 502
++VE +N W M R G A+L M+ GG+DG +L+ E +
Sbjct: 489 TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGR 548
Query: 503 QWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACHEG 562
QW + M T RS V +VA +LYA+GG DG S L S+E +DP T+ W+ APM+ G
Sbjct: 549 QWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRG 608
Query: 563 GVGV 566
GVGV
Sbjct: 609 GVGV 612
Score = 61.6 bits (148), Expect = 2e-09
Identities = 33/107 (30%), Positives = 54/107 (50%), Gaps = 1/107 (0%)
Query: 463 MLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVAS 522
M + R + +++G+ ++ GG D + E Y + W I M+ RR + +
Sbjct: 416 MQSPRTKPRKSTVGA-LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVI 474
Query: 523 CGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACHEGGVGVGCI 569
+LY VGG DG L++VE ++P WT M PM+ H G+GV +
Sbjct: 475 DNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATL 521
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 391 bits (1005), Expect = e-109
Identities = 212/536 (39%), Positives = 307/536 (57%), Gaps = 13/536 (2%)
Query: 31 IRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALE 90
+R+ +LCD+ L++GD K AH++VLA+ PYF AMFT ++ E + E+ Q +D +AL+
Sbjct: 28 LRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEVEFQCIDETALQ 87
Query: 91 ALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETM 150
A++ +AY G + I Q V+SLL A+ LQ++ + CC FL +L P NC+G+ +FAET
Sbjct: 88 AIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGNCIGISRFAETY 147
Query: 151 MCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVR 210
C LY AA +I Q+F V +EEF L D+ E+VS D LNV +EE VF A +W++
Sbjct: 148 GCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEETVFYALESWIK 207
Query: 211 YDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERR 270
YD ++R YL +LL+++RLPL +FL+ + + L+R C+ L++EA YH MPE R
Sbjct: 208 YDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHFMPEHR 267
Query: 271 -PHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRV 329
H TRPRC + + AVGG + L+ VE++ P + W P+ R
Sbjct: 268 LSHQTVLMTRPRCAPKV---LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEF 324
Query: 330 GVAVVNGLLYAIGGYDGQLR--------LSTVEAYNPETDTWTRVGSMNSKRSAMGTVVL 381
G+ V++ +Y IGG +R ++VE +NP+T+TWT + MN RS +G VVL
Sbjct: 325 GICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVL 384
Query: 382 DGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGL 441
G++Y GGYDG S L SVE Y P+ KW V M++ RS V +G IY GG+ G
Sbjct: 385 AGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY-GP 443
Query: 442 QIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVA 501
+SVE Y+ +W A M +KR G + +FV GG++G LS E Y
Sbjct: 444 AHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQ 503
Query: 502 DQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPM 557
+QW + PM R+ V LY VGG+ G S L++V+ YDP +D W A M
Sbjct: 504 NQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGM 559
Score = 147 bits (370), Expect = 3e-35
Identities = 77/190 (40%), Positives = 110/190 (57%), Gaps = 2/190 (1%)
Query: 286 IAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYD 345
+AG +YA+GG + L VE + P W+ PMTT RS AV++G++YAIGGY
Sbjct: 384 LAGELYALGGYDGQS-YLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY- 441
Query: 346 GQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSP 405
G +++VE Y+P D+W V SM KR G V+ G I+V GG++G S LSS+E Y P
Sbjct: 442 GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDP 501
Query: 406 ETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLN 465
++WTV M R+ G V + +YV GGH G ++V+ Y+ + TW +AGM+
Sbjct: 502 HQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIY 561
Query: 466 KRCRHGAASL 475
RC G +L
Sbjct: 562 CRCNFGLTAL 571
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 380 bits (976), Expect = e-105
Identities = 204/568 (35%), Positives = 311/568 (54%), Gaps = 7/568 (1%)
Query: 10 EDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTN 69
ED F +E +G + G+LCDVTLK+G S H++VLA IPYF AMF +
Sbjct: 39 EDSFIFEANEAWKDFHGSLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLS 98
Query: 70 DMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCT 129
+M E KQ I ++ D A+E L+ F Y+ L + NVQ LL A LQ++ + ACC
Sbjct: 99 EMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCE 158
Query: 130 FLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVS 189
+++ HP NCL VR FAE+ L D A+ + HF EV E+F+++ + + +L+S
Sbjct: 159 YMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLS 218
Query: 190 RDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRC 249
+LN+++E+QV+ AA+ W+ + + +L E L+ +RLPL FL V ++ +V+
Sbjct: 219 SSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQ 278
Query: 250 CHKCRDLVDEAKDYHLMPERRPHLPAF----RTRPRCCTSIAGLIYAVGGLNSAGDSLNV 305
KCRDL+DEA++YHL R +P F RT PR T AG+++ VGG +GD
Sbjct: 279 NLKCRDLLDEARNYHLHLSSRA-VPDFEYSIRTTPRKHT--AGVLFCVGGRGGSGDPFRS 335
Query: 306 VEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTR 365
+E + N W M + R VGV V G +YA+GG+DG L ++E ++P T+ W
Sbjct: 336 IECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMM 395
Query: 366 VGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGV 425
SMN+KR + L G IY GG D N+ + VE Y E+D+W+ V M++ R G
Sbjct: 396 KASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGS 455
Query: 426 TVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGY 485
+Y GG+DG+ SSVE Y+ H W M +R +G + L ++V GG+
Sbjct: 456 VALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGF 515
Query: 486 DGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYD 545
D + LS E Y +++W + + T R V + G+++AVGG++G + L++VE +D
Sbjct: 516 DDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFD 575
Query: 546 PETDCWTFMAPMACHEGGVGVGCIPLLT 573
P + W + ++ G GV LT
Sbjct: 576 PVLNRWELVGSVSHCRAGAGVAVCSCLT 603
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 368 bits (945), Expect = e-102
Identities = 190/488 (38%), Positives = 289/488 (59%), Gaps = 5/488 (1%)
Query: 71 MMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTF 130
M E + + ++ +D L LI++ Y + + ++NVQ LL A LQLQ +K CC F
Sbjct: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
Query: 131 LRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSR 190
L +LHP NCLG+R FA+ C L + AN++ QHF +V +SEEFL L +E V L+S
Sbjct: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
Query: 191 DELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCC 250
D+L + SEE+VFEA +AWV +D++ R ++ L+ ++RLPL ++L RV+++ LV+
Sbjct: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
Query: 251 HKCRDLVDEAKDYHLMP-ERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVF 309
C+D + EA YHL+P E+R + + RTR R ++ L+ VGG A ++ VE +
Sbjct: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG--QAPKAIRSVECY 238
Query: 310 DPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSM 369
D W + + + R R G+ + GL++A+GG++G LR+ TV++Y+P D WT V +M
Sbjct: 239 DFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANM 298
Query: 370 NSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFE 429
+RS +G VL+G +Y GG+DG++ LSSVE Y+ ++++W V M++ RS+ GV V
Sbjct: 299 RDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG 358
Query: 430 GRIYVSGGHDGL--QIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDG 487
G +Y GG+DG Q S+VE YN T W A M +R G L + ++ GG+DG
Sbjct: 359 GLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDG 418
Query: 488 SGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPE 547
E+Y + W + M+ R + A G LY VGG DG NL+SVE Y+P
Sbjct: 419 PLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPT 478
Query: 548 TDCWTFMA 555
TD WT ++
Sbjct: 479 TDKWTVVS 486
Score = 136 bits (342), Expect = 6e-32
Identities = 71/146 (48%), Positives = 95/146 (65%), Gaps = 2/146 (1%)
Query: 286 IAGLIYAVGGLNSAG-DSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGY 344
+ GL+YAVGG + A L+ VE ++ N W M+T RS GV V+N LLYA+GG+
Sbjct: 357 VGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGH 416
Query: 345 DGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYS 404
DG L +VE Y+P T+ W +V MN R G ++G +YV GG DG+ +L+SVE Y+
Sbjct: 417 DGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 476
Query: 405 PETDKWTVVTS-MSSNRSAAGVTVFE 429
P TDKWTVV+S MS+ RS AGVTV +
Sbjct: 477 PTTDKWTVVSSCMSTGRSYAGVTVID 502
Score = 127 bits (318), Expect = 4e-29
Identities = 72/203 (35%), Positives = 109/203 (53%), Gaps = 2/203 (0%)
Query: 369 MNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVF 428
M S R+ + T + ++ V G ++ SVE Y + ++W V + S R AG+
Sbjct: 204 MKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYM 263
Query: 429 EGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGS 488
G ++ GG +G +V+ Y+ W A M ++R GAA L ++ GG+DGS
Sbjct: 264 AGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGS 323
Query: 489 GFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSN--LSSVEMYDP 546
LS E Y+ +++W + PM+TRRS V + G LYAVGGYDG S LS+VE Y+
Sbjct: 324 TGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNA 383
Query: 547 ETDCWTFMAPMACHEGGVGVGCI 569
T+ WT++A M+ G GVG +
Sbjct: 384 TTNEWTYIAEMSTRRSGAGVGVL 406
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 343 bits (879), Expect = 3e-94
Identities = 190/556 (34%), Positives = 304/556 (54%), Gaps = 48/556 (8%)
Query: 15 FSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDH-----KFSAHRIVLAASIPYFHAMFTN 69
+++ + + +G+M E+R +LCDVTL++ +F AH++VLA+S P F AMFTN
Sbjct: 54 YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTN 113
Query: 70 DMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCT 129
+ E + + ++G+ P +E LI FAY ++++ ++ V ++ GA Q+ S+ AC
Sbjct: 114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
Query: 130 FLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVS 189
FL ++L P N +G+ FAE + C L+ A +I+ HF EV+ EEF L ++ L+S
Sbjct: 174 FLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLIS 233
Query: 190 RDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRC 249
RD+LNV+ E +VF A + WV+YD EQR Y+ LL +R P FL ++Q+ ++++
Sbjct: 234 RDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQS 293
Query: 250 CHKCRDLVDEA-------KDYHLMPERRP------------------HLPAFRTR----- 279
+C+D + + K +MP R P +L A+
Sbjct: 294 DSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWL 353
Query: 280 -------PRCCTS---IAGLIYAVGGLNSAGD---SLNVVEVFDPIANCWERCRPMTTAR 326
PR + + GL+YAVGG N++ D + ++ ++P+ N W C PM+ R
Sbjct: 354 RLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPR 413
Query: 327 SRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIY 386
+R+GV V++G +YA+GG G + ++VE Y PE D W V M ++R +G VL+ +Y
Sbjct: 414 NRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLY 473
Query: 387 VCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSS 446
GG+DG + L+S E Y PE ++W ++T+M++ RS AGV V IY +GG+DG +S
Sbjct: 474 AVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNS 533
Query: 447 VEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCL 506
VE Y+ T TW A M ++R G +++V GGYDG FL E Y D W
Sbjct: 534 VERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSE 593
Query: 507 IVPMHTRRSRVSLVAS 522
+ M + RS V + +
Sbjct: 594 VTRMTSGRSGVGVAVT 609
Score = 77.4 bits (189), Expect = 3e-14
Identities = 48/142 (33%), Positives = 69/142 (48%), Gaps = 5/142 (3%)
Query: 432 IYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGY----DG 487
IY +GG+ Q S +E YN TW A + R +G ++ GG DG
Sbjct: 328 IYTAGGYFR-QSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
Query: 488 SGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPE 547
+ S + Y+ + +QW PM R+R+ + G +YAVGG G + +SVE Y+PE
Sbjct: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
Query: 548 TDCWTFMAPMACHEGGVGVGCI 569
D W +APM GVGV +
Sbjct: 447 RDEWHLVAPMLTRRIGVGVAVL 468
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 343 bits (879), Expect = 3e-94
Identities = 190/556 (34%), Positives = 304/556 (54%), Gaps = 48/556 (8%)
Query: 15 FSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDH-----KFSAHRIVLAASIPYFHAMFTN 69
+++ + + +G+M E+R +LCDVTL++ +F AH++VLA+S P F AMFTN
Sbjct: 54 YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTN 113
Query: 70 DMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCT 129
+ E + + ++G+ P +E LI FAY ++++ ++ V ++ GA Q+ S+ AC
Sbjct: 114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
Query: 130 FLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVS 189
FL ++L P N +G+ FAE + C L+ A +I+ HF EV+ EEF L ++ L+S
Sbjct: 174 FLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLIS 233
Query: 190 RDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRC 249
RD+LNV+ E +VF A + WV+YD EQR Y+ LL +R P FL ++Q+ ++++
Sbjct: 234 RDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQS 293
Query: 250 CHKCRDLVDEA-------KDYHLMPERRP------------------HLPAFRTR----- 279
+C+D + + K +MP R P +L A+
Sbjct: 294 DSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWL 353
Query: 280 -------PRCCTS---IAGLIYAVGGLNSAGD---SLNVVEVFDPIANCWERCRPMTTAR 326
PR + + GL+YAVGG N++ D + ++ ++P+ N W C PM+ R
Sbjct: 354 RLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPR 413
Query: 327 SRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIY 386
+R+GV V++G +YA+GG G + ++VE Y PE D W V M ++R +G VL+ +Y
Sbjct: 414 NRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLY 473
Query: 387 VCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSS 446
GG+DG + L+S E Y PE ++W ++T+M++ RS AGV V IY +GG+DG +S
Sbjct: 474 AVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNS 533
Query: 447 VEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCL 506
VE Y+ T TW A M ++R G +++V GGYDG FL E Y D W
Sbjct: 534 VERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSE 593
Query: 507 IVPMHTRRSRVSLVAS 522
+ M + RS V + +
Sbjct: 594 VTRMTSGRSGVGVAVT 609
Score = 77.4 bits (189), Expect = 3e-14
Identities = 48/142 (33%), Positives = 69/142 (48%), Gaps = 5/142 (3%)
Query: 432 IYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGY----DG 487
IY +GG+ Q S +E YN TW A + R +G ++ GG DG
Sbjct: 328 IYTAGGYFR-QSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
Query: 488 SGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPE 547
+ S + Y+ + +QW PM R+R+ + G +YAVGG G + +SVE Y+PE
Sbjct: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
Query: 548 TDCWTFMAPMACHEGGVGVGCI 569
D W +APM GVGV +
Sbjct: 447 RDEWHLVAPMLTRRIGVGVAVL 468
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 316 bits (810), Expect = 3e-86
Identities = 178/550 (32%), Positives = 287/550 (52%), Gaps = 10/550 (1%)
Query: 27 VMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDP 86
+ E+R +GKLCDV +K+ +FSAH+ +L + YF A+FT+ ++ + G+ P
Sbjct: 28 IFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISP 87
Query: 87 SALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQF 146
++ +I +AY + I NV+ LL A + I CC FL+ L NC+G+ +F
Sbjct: 88 DMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKF 147
Query: 147 AETMMCAVLYDAANSFIHQHFVE-VSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAA 205
+ C L A FI +F E V +S EFL L + ++ +++ +DELNVK E+ VFEA
Sbjct: 148 TDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAI 207
Query: 206 LAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEA-KDYH 264
L W+ +D + R ++ LL +RL L ++ + V+ +D V+ +C+ ++ A K +
Sbjct: 208 LKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMY 267
Query: 265 LMPERRPHLPAFR---TRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCR- 320
+ P F TRPR +I ++A+GG S G N +E +D A+ W
Sbjct: 268 DLNMNGPSNSDFTNPLTRPRLPYAI---LFAIGGW-SGGSPTNAIEAYDARADRWVNVTC 323
Query: 321 PMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVV 380
+ R+ G A + G +Y IGG+D ++V+ ++P TW +V M+S+R + V
Sbjct: 324 EEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTV 383
Query: 381 LDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDG 440
L IY GG+DG L++ E Y PET++WT++ M RS A T G++Y+ GG +G
Sbjct: 384 LGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNG 443
Query: 441 LQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSV 500
+ + E YN + W A M ++R G + G ++ GG+DG+ L AE YS V
Sbjct: 444 NECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPV 503
Query: 501 ADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACH 560
A+ W I M RS + L+ VGG++G + +VE YD +TD W M+ +
Sbjct: 504 ANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIY 563
Query: 561 EGGVGVGCIP 570
+ +P
Sbjct: 564 RSALSCCVVP 573
Score = 102 bits (255), Expect = 7e-22
Identities = 54/147 (36%), Positives = 82/147 (55%), Gaps = 1/147 (0%)
Query: 284 TSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGG 343
T++ G +Y GG N + L EV++ +N W PM + RS +GV +YA+GG
Sbjct: 429 TTLYGKVYICGGFNG-NECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGG 487
Query: 344 YDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETY 403
+DG RL + EAY+P +TW + +M + RS G V+D ++V GG++G ++ +VE Y
Sbjct: 488 FDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECY 547
Query: 404 SPETDKWTVVTSMSSNRSAAGVTVFEG 430
+TD+W MS RSA V G
Sbjct: 548 DEKTDEWYDAHDMSIYRSALSCCVVPG 574
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 311 bits (798), Expect = 8e-85
Identities = 190/560 (33%), Positives = 291/560 (51%), Gaps = 24/560 (4%)
Query: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS 87
+ ++R CDV L++G F AHR+VLAAS PYF A+FT M E +D + + G++
Sbjct: 27 INKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAG 86
Query: 88 ALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFA 147
+ L++F Y G + I NVQ L++ A LQL + CC FL+ ++ P NC+G+ QF+
Sbjct: 87 IFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFS 146
Query: 148 ETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALA 207
E + C L + + ++IH HF+EV EEFLAL + +++++ +EL+++ E QVF AA+
Sbjct: 147 EQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQ 206
Query: 208 WVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMP 267
W+ D +R ++ E+L IR PL PQ L ++ + L+ E + P
Sbjct: 207 WILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSP 266
Query: 268 ERR---PHLPAFRTRPRCCTSIAGLIYAVGGLN-------SAGDSLNVVEVFDPIANCWE 317
+ L + RPR +YAVGG S +L+ VE FD + W
Sbjct: 267 KENKFCSFLQTSKVRPR--KKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWT 324
Query: 318 RCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMG 377
+ ARS +GV V+ G++YAIGG + E Y+P T WT V SMN R +G
Sbjct: 325 TVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLG 384
Query: 378 TVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGG 437
V G IY GG+ G +++E + P+ +KW VV +M+ +R G +G IYV GG
Sbjct: 385 VCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGG 444
Query: 438 --HDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGY-DGSGFLSIA 494
++G+++ S E Y+ + W P M +R G A+L ++ GG+ + L
Sbjct: 445 ISNEGIEL-RSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTV 503
Query: 495 EMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGG------YDGQSNLSSVEMYDPET 548
E YS ++W + M R+ + +VA G LY GG + L SVE+Y+P +
Sbjct: 504 EKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHS 563
Query: 549 DCWTFMAPMACH--EGGVGV 566
D WT + M EGGV V
Sbjct: 564 DTWTEIGNMITSRCEGGVAV 583
Score = 120 bits (300), Expect = 4e-27
Identities = 83/245 (33%), Positives = 118/245 (48%), Gaps = 22/245 (8%)
Query: 242 QQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIA---GLIYAVGGLNS 298
++D ++ C +C D V K + + A PRC + G IYA+GG
Sbjct: 351 EKDSMIFDCTECYDPV--TKQWTTV--------ASMNHPRCGLGVCVCYGAIYALGGWVG 400
Query: 299 AGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQ-LRLSTVEAYN 357
A + N +E FDP N WE M +R G + GL+Y IGG + + L + E Y+
Sbjct: 401 A-EIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYD 459
Query: 358 PETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGY-DGNSSLSSVETYSPETDKWTVVTSM 416
P + W+ + M ++R+ +G L+ IY GG+ + +L +VE YS E +KW V SM
Sbjct: 460 PLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASM 519
Query: 417 SSNRSAAGVTVFEGRIYVSGG----HDGLQ--IFSSVEHYNHHTATWHPAAGMLNKRCRH 470
R+ V G +YVSGG HD L SVE YN H+ TW M+ RC
Sbjct: 520 KVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEG 579
Query: 471 GAASL 475
G A L
Sbjct: 580 GVAVL 584
Score = 90.1 bits (222), Expect = 5e-18
Identities = 55/194 (28%), Positives = 84/194 (43%), Gaps = 9/194 (4%)
Query: 385 IYVCGGY--------DGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSG 436
+Y GGY + +LS VE + + WT V+S+ RS GVTV G +Y G
Sbjct: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
Query: 437 GHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEM 496
G IF E Y+ T W A M + RC G ++ GG+ G+ + E
Sbjct: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIER 409
Query: 497 YSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQS-NLSSVEMYDPETDCWTFMA 555
+ ++W ++ M R G +Y +GG + L S E+YDP + W+ +
Sbjct: 410 FDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLP 469
Query: 556 PMACHEGGVGVGCI 569
PM +GV +
Sbjct: 470 PMGTRRAYLGVAAL 483
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 301 bits (770), Expect = 1e-81
Identities = 177/532 (33%), Positives = 273/532 (51%), Gaps = 14/532 (2%)
Query: 26 GVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMD 85
GVM +R+Q LCDV L + + K AHR+VLAA+ +F+ MFT +M+E K E+ ++ +
Sbjct: 32 GVMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAE 91
Query: 86 PSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQ 145
P +E L+ FAY ++++ NVQSLL A+ Q++ +K C FL+E++ NCLG+
Sbjct: 92 PDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISV 151
Query: 146 FAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAA 205
AE + C L A+ FIHQHF EV ++EFL L ++ V L+++D L V++E+QV++AA
Sbjct: 152 LAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAA 211
Query: 206 LAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHL 265
+ W++YD R P++ ++L+ +R PL FLS VQ + L++ +C +V YHL
Sbjct: 212 VRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHL 271
Query: 266 M-PERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTT 324
+ PE R L TRPR A+ G G F+P W R
Sbjct: 272 LSPEDREEL-VDGTRPR--RKKHDYRIALFG----GSQPQSCRYFNPKDYSWTDIRCPFE 324
Query: 325 ARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQ 384
R + ++Y +GG + ++ YN D+W + R ++ +G+
Sbjct: 325 KRRDAACVFWDNVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGK 383
Query: 385 IYVCGGYD-GNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGL-- 441
IY GG + GNS+L E Y T+ W SM + R + G+ G IYV GG G
Sbjct: 384 IYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNV 443
Query: 442 --QIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSS 499
++ +S E Y+ T TW M+ R HG + K+F GG +G G L E Y
Sbjct: 444 SGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDI 503
Query: 500 VADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCW 551
++W ++ PM + V A +Y + G+ G L + Y+ ETD W
Sbjct: 504 KLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 555
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 294 bits (752), Expect = 2e-79
Identities = 175/517 (33%), Positives = 271/517 (52%), Gaps = 16/517 (3%)
Query: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS 87
+ ++R CDV L++G F AHR+VLAAS PYF A+FT M E +D + + G++
Sbjct: 27 INKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAG 86
Query: 88 ALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFA 147
+ L++F Y G + I NVQ L++ A LQL + CC FL+ ++ P NC+G+ QF+
Sbjct: 87 IFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFS 146
Query: 148 ETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALA 207
E + C L + + ++IH HF+EV EEFLAL + +++++ +EL+++ E QVF AA+
Sbjct: 147 EQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQ 206
Query: 208 WVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMP 267
W+ D +R ++ E+L IR PL PQ L ++ + L+ E + P
Sbjct: 207 WILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSP 266
Query: 268 ERR---PHLPAFRTRPRCCTSIAGLIYAVGGLN-------SAGDSLNVVEVFDPIANCWE 317
+ L + RPR +YAVGG S +L+ VE FD + W
Sbjct: 267 KENKFCSFLQTSKVRPR--KKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWT 324
Query: 318 RCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMG 377
+ ARS +GV V+ G++YAIGG + E Y+P T WT V SMN R +G
Sbjct: 325 TVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLG 384
Query: 378 TVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGG 437
V G IY GG+ G +++E + P+ +KW VV +M+ +R G +G IYV GG
Sbjct: 385 VCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGG 444
Query: 438 --HDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGY-DGSGFLSIA 494
++G+++ S E Y+ + W P M +R G A+L ++ GG+ + L
Sbjct: 445 ISNEGIEL-RSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTV 503
Query: 495 EMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGG 531
E YS ++W + M R+ + +VA G LY GG
Sbjct: 504 EKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
Score = 99.4 bits (246), Expect = 8e-21
Identities = 67/216 (31%), Positives = 104/216 (48%), Gaps = 16/216 (7%)
Query: 242 QQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIA---GLIYAVGGLNS 298
++D ++ C +C D V K + + A PRC + G IYA+GG
Sbjct: 351 EKDSMIFDCTECYDPV--TKQWTTV--------ASMNHPRCGLGVCVCYGAIYALGGWVG 400
Query: 299 AGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQ-LRLSTVEAYN 357
A + N +E FDP N WE M +R G + GL+Y IGG + + L + E Y+
Sbjct: 401 A-EIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYD 459
Query: 358 PETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGY-DGNSSLSSVETYSPETDKWTVVTSM 416
P + W+ + M ++R+ +G L+ IY GG+ + +L +VE YS E +KW V SM
Sbjct: 460 PLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASM 519
Query: 417 SSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNH 452
R+ V G +YVSGG F + + + +
Sbjct: 520 KVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPDTHRY 555
Score = 93.2 bits (230), Expect = 6e-19
Identities = 49/131 (37%), Positives = 76/131 (58%), Gaps = 6/131 (4%)
Query: 283 CTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIG 342
C + GLIY +GG+++ G L EV+DP++ W PM T R+ +GVA +N +Y++G
Sbjct: 432 CCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVG 491
Query: 343 GY-DGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVE 401
G+ + Q L TVE Y+ E + W V SM R+ M V ++G +YV GG SS +
Sbjct: 492 GWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRS-----SSHD 546
Query: 402 TYSPETDKWTV 412
+P+T ++ V
Sbjct: 547 FLAPDTHRYEV 557
Score = 90.1 bits (222), Expect = 5e-18
Identities = 55/194 (28%), Positives = 84/194 (43%), Gaps = 9/194 (4%)
Query: 385 IYVCGGY--------DGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSG 436
+Y GGY + +LS VE + + WT V+S+ RS GVTV G +Y G
Sbjct: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
Query: 437 GHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEM 496
G IF E Y+ T W A M + RC G ++ GG+ G+ + E
Sbjct: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIER 409
Query: 497 YSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQS-NLSSVEMYDPETDCWTFMA 555
+ ++W ++ M R G +Y +GG + L S E+YDP + W+ +
Sbjct: 410 FDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLP 469
Query: 556 PMACHEGGVGVGCI 569
PM +GV +
Sbjct: 470 PMGTRRAYLGVAAL 483
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 291 bits (745), Expect = 1e-78
Identities = 172/521 (33%), Positives = 266/521 (51%), Gaps = 14/521 (2%)
Query: 37 LCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFA 96
LCDV L + + K AHR+VLAA+ +F+ MFT +M+E K E+ ++ +P +E L+ FA
Sbjct: 21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFA 80
Query: 97 YNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLY 156
Y ++++ NVQSLL A+ Q++ +K C FL+E++ NCLG+ AE + C L
Sbjct: 81 YTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELK 140
Query: 157 DAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQR 216
A+ FIHQHF EV ++EFL L ++ V L+++D L V++E+QV++AA+ W++YD R
Sbjct: 141 ATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNR 200
Query: 217 GPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLM-PERRPHLPA 275
P++ ++L+ +R PL FLS VQ + L++ +C +V YHL+ PE R L
Sbjct: 201 QPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREEL-V 259
Query: 276 FRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVN 335
TRPR A+ G G F+P W R R +
Sbjct: 260 DGTRPR--RKKHDYRIALFG----GSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWD 313
Query: 336 GLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYD-GN 394
++Y +GG + ++ YN D+W + R ++ +G+IY GG + GN
Sbjct: 314 NVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGN 372
Query: 395 SSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGL----QIFSSVEHY 450
S+L E Y T+ W SM + R + G+ G IYV GG G ++ +S E Y
Sbjct: 373 SALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVY 432
Query: 451 NHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPM 510
+ T TW M+ R HG + K+F GG +G G L E Y ++W ++ PM
Sbjct: 433 DPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPM 492
Query: 511 HTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCW 551
+ V A +Y + G+ G L + Y+ ETD W
Sbjct: 493 PWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 533
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 278 bits (712), Expect = 7e-75
Identities = 175/537 (32%), Positives = 271/537 (50%), Gaps = 19/537 (3%)
Query: 27 VMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDP 86
+ E R DV + + +F HR VL+A YF AMF ND E ++ + + G+
Sbjct: 55 IFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILA 114
Query: 87 SALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQF 146
A+E + + Y G + I +NVQ L +S Q+ ++DAC FL E+L P NCLG+++F
Sbjct: 115 EAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRF 174
Query: 147 AETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAAL 206
A+T L+ +F Q F +VS EEFL L +++++ + DEL + EE VFEA +
Sbjct: 175 ADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVM 234
Query: 207 AWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLM 266
WV + R P L ELL+++RLPL P + V+ D L++ +C L+ EA+ YH++
Sbjct: 235 RWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHIL 294
Query: 267 PERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGD-SLNVVEVFDPIANCWERCR--PMT 323
+ + RTRPR T + +I VGG G +L E +DP+ W+ P
Sbjct: 295 GN---EMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEF 351
Query: 324 TARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDG 383
T A+ N +L + G++ V YN + + W RV S+N R VL G
Sbjct: 352 TKSEYAVCALRNDILVS----GGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLG 407
Query: 384 QIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYV-SGGHDGLQ 442
++YV GGYDG + LSSVE Y +++WT V + S+ VT G+++V GG D
Sbjct: 408 KVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNT 467
Query: 443 IFSSVEHYNHHTATWHPAAGM-LNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVA 501
V+ Y+ T +W A + + KRC A SL + ++V GG + + Y V
Sbjct: 468 CSDKVQSYDPETNSWLLRAAIPIAKRC-ITAVSLNNLIYVAGGLTKAIY-----CYDPVE 521
Query: 502 DQWCLIVPMHTRRSRVSLVASCGRLYAVGG-YDGQSNLSSVEMYDPETDCWTFMAPM 557
D W + +R+ + G++Y +GG + ++ YDP T T +A M
Sbjct: 522 DYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAM 578
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 270 bits (691), Expect = 2e-72
Identities = 178/552 (32%), Positives = 279/552 (50%), Gaps = 21/552 (3%)
Query: 29 EEIRRQGKLCDVTLKIGD--HKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDP 86
+++R +G LCDVTL GD F HR+++A++ YF AMFT M E I + G+
Sbjct: 83 DQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSK 142
Query: 87 SALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQF 146
L +I+F Y L+++ N+Q L ASFLQ+ + D C FL + NC+ V +
Sbjct: 143 VGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRI 202
Query: 147 AETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAAL 206
A T + NSF+ ++F + + EFL LP E + ++S + L +E ++F+A
Sbjct: 203 ANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATC 262
Query: 207 AWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLM 266
W+R + E R + +L+ NIR PL PQ L + VQ D +R + C +L+ EA +Y +M
Sbjct: 263 RWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMM 321
Query: 267 PERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTAR 326
P +P + + RT R T+ L+ G L + ++D A+ W+ PM R
Sbjct: 322 PYMQPVMQSDRTAIRSDTT--HLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPR 379
Query: 327 SRVGVAVVNGLLYAIGG---YD--GQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVL 381
+ G+AV+ LY +GG YD G+ + TV ++P + W +V S+N KR+ L
Sbjct: 380 YQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSAL 439
Query: 382 DGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGG--HD 439
G +Y GG + L +VE Y+P T++WT V MS TV+ G +Y+SGG HD
Sbjct: 440 KGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHD 499
Query: 440 GLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGF-----LSIA 494
Q + ++ T W A M R H ++G +++V GG G +
Sbjct: 500 TFQ--KELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSC 557
Query: 495 EMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGY--DGQSNLSSVEMYDPETDCWT 552
E YS + DQW I M +S V + ++Y VGGY + + + V+ YDP+ D W
Sbjct: 558 EYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWH 617
Query: 553 FMAPMACHEGGV 564
+ + GG+
Sbjct: 618 KVFDLPESLGGI 629
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 267 bits (682), Expect = 2e-71
Identities = 178/552 (32%), Positives = 277/552 (50%), Gaps = 21/552 (3%)
Query: 29 EEIRRQGKLCDVTLKIGDHK--FSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDP 86
+++R +G LCDVTL GD F HR ++A++ YF AMFT M E I + G++
Sbjct: 41 DQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNK 100
Query: 87 SALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQF 146
L+ +I+F Y L+++ N+Q L ASFLQ+ + D C FL + NC+ V +
Sbjct: 101 VGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRI 160
Query: 147 AETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAAL 206
A T + N+FI ++F + + EFL LP E + ++S + L +E ++F+AA
Sbjct: 161 ANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAAC 220
Query: 207 AWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLM 266
W+R + + R Y +L+ NIR PL PQ L + VQ D +R + C +L+ EA +Y +M
Sbjct: 221 RWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMM 279
Query: 267 PERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTAR 326
P +P + + RT R + L+ G L + ++D A W PM R
Sbjct: 280 PYMQPVMQSDRTAIR--SDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPR 337
Query: 327 SRVGVAVVNGLLYAIGG---YD--GQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVL 381
+ G+AV+ LY +GG YD G+ + TV ++P + W +V S+N KR+ L
Sbjct: 338 YQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSAL 397
Query: 382 DGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGG--HD 439
G +Y GG L++VE Y+P ++W+ V MS TV+ G +Y+SGG HD
Sbjct: 398 KGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHD 457
Query: 440 GLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGF-----LSIA 494
Q + + ++ T W A M R H ++G K++V GG G +
Sbjct: 458 TFQ--NELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSC 515
Query: 495 EMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGY--DGQSNLSSVEMYDPETDCWT 552
E YS DQW I M +S V + ++Y VGGY + + + V+ YDPE D W
Sbjct: 516 EYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWH 575
Query: 553 FMAPMACHEGGV 564
+ + GG+
Sbjct: 576 KVFDLPESLGGI 587
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 265 bits (678), Expect = 7e-71
Identities = 169/544 (31%), Positives = 253/544 (46%), Gaps = 16/544 (2%)
Query: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQD-----EIVMQ 82
+ + RR D+ + + +F H+ VLA+ YF + + + Q E+V+
Sbjct: 319 LNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLS 378
Query: 83 GMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLG 142
+ LE L+ F Y G+L ID N ++LL AS Q + C +FL ++L NCLG
Sbjct: 379 NLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Query: 143 VRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVF 202
V AE M C+ LY A +F Q F EV+ EE L++ +D + VS D LN K+EE V+
Sbjct: 439 VLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVY 498
Query: 203 EAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKD 262
E + W++ D R Y ELL+ +RLP P +L + V ++L++ CRDLV+EAK
Sbjct: 499 ETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKR 558
Query: 263 YHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAG---DSLNVVEVFDPIANCWERC 319
YH++P R + RTRPR +A +I VGG G SL V ++P N W
Sbjct: 559 YHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPL 618
Query: 320 RPMT-TARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGT 378
+ R V +Y GG + + L+ V Y D W V M R +
Sbjct: 619 ASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNS 678
Query: 379 VVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGG- 437
+V DG+IY GG ++ VE Y T++W V + +A TV G+IYV GG
Sbjct: 679 LVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGV 738
Query: 438 HDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMY 497
++ + ++ Y T TW + A +L +F+ GG + +Y
Sbjct: 739 NEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG----AYARATTIY 794
Query: 498 SSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSN--LSSVEMYDPETDCWTFMA 555
M+ R S V G++YA GG L ++E Y+P T+ WT +
Sbjct: 795 DPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLP 854
Query: 556 PMAC 559
M C
Sbjct: 855 HMPC 858
Score = 38.1 bits (87), Expect = 0.022
Identities = 32/143 (22%), Positives = 47/143 (32%), Gaps = 45/143 (31%)
Query: 284 TSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGG 343
T G IY GG+N AG + V++ + P N W +NG ++ +GG
Sbjct: 726 TVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG 785
Query: 344 ---------------------------------YDGQL------------RLSTVEAYNP 358
DG++ L +EAY P
Sbjct: 786 AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEP 845
Query: 359 ETDTWTRVGSMNSKRSAMGTVVL 381
T+TWT + M G VV+
Sbjct: 846 TTNTWTLLPHMPCPVFRHGCVVI 868
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 265 bits (678), Expect = 7e-71
Identities = 169/544 (31%), Positives = 253/544 (46%), Gaps = 16/544 (2%)
Query: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQD-----EIVMQ 82
+ + RR D+ + + +F H+ VLA+ YF + + + Q E+V+
Sbjct: 319 LNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLS 378
Query: 83 GMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLG 142
+ LE L+ F Y G+L ID N ++LL AS Q + C +FL ++L NCLG
Sbjct: 379 NLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Query: 143 VRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVF 202
V AE M C+ LY A +F Q F EV+ EE L++ +D + VS D LN K+EE V+
Sbjct: 439 VLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVY 498
Query: 203 EAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKD 262
E + W++ D R Y ELL+ +RLP P +L + V ++L++ CRDLV+EAK
Sbjct: 499 ETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKR 558
Query: 263 YHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAG---DSLNVVEVFDPIANCWERC 319
YH++P R + RTRPR +A +I VGG G SL V ++P N W
Sbjct: 559 YHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPL 618
Query: 320 RPMT-TARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGT 378
+ R V +Y GG + + L+ V Y D W V M R +
Sbjct: 619 ASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNS 678
Query: 379 VVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGG- 437
+V DG+IY GG ++ VE Y T++W V + +A TV G+IYV GG
Sbjct: 679 LVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGV 738
Query: 438 HDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMY 497
++ + ++ Y T TW + A +L +F+ GG + +Y
Sbjct: 739 NEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG----AYARATTIY 794
Query: 498 SSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSN--LSSVEMYDPETDCWTFMA 555
M+ R S V G++YA GG L ++E Y+P T+ WT +
Sbjct: 795 DPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLP 854
Query: 556 PMAC 559
M C
Sbjct: 855 HMPC 858
Score = 38.1 bits (87), Expect = 0.022
Identities = 32/143 (22%), Positives = 47/143 (32%), Gaps = 45/143 (31%)
Query: 284 TSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGG 343
T G IY GG+N AG + V++ + P N W +NG ++ +GG
Sbjct: 726 TVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG 785
Query: 344 ---------------------------------YDGQL------------RLSTVEAYNP 358
DG++ L +EAY P
Sbjct: 786 AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEP 845
Query: 359 ETDTWTRVGSMNSKRSAMGTVVL 381
T+TWT + M G VV+
Sbjct: 846 TTNTWTLLPHMPCPVFRHGCVVI 868
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 261 bits (667), Expect = 1e-69
Identities = 162/532 (30%), Positives = 263/532 (49%), Gaps = 23/532 (4%)
Query: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS 87
+E +R + L DV L + +FS HR+VLAA+ YF AMF ND+ E + I+++G+D
Sbjct: 62 LETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAE 121
Query: 88 ALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFA 147
+ L+++ Y I +QNVQ +L A+ Q + DAC +FL E L+P+NC+G+ + A
Sbjct: 122 TMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLA 181
Query: 148 ETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALA 207
+T L S+I Q+FV++ SEEFL LP++ + ++ D+L V E QVFE ++
Sbjct: 182 DTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMS 241
Query: 208 WVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMP 267
WVR+ +R LP +L N+RLPL P + + V+ D L+R C + L+ EA+ YHL
Sbjct: 242 WVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSG 301
Query: 268 ERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARS 327
+ + RT+PR + + +GG + V DP+ +
Sbjct: 302 N---EIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEH 358
Query: 328 RV----------GVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMG 377
+ + +Y GG + Q V YN + W ++ +N R
Sbjct: 359 ELESENKKWVEFACVTLKNEVYISGGKETQ---HDVWKYNSSINKWIQIEYLNIGRWRHK 415
Query: 378 TVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYV-SG 436
VVL G++YV GG+DG +++VETY P + W+ + + S+ T + ++YV G
Sbjct: 416 MVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGG 475
Query: 437 GHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEM 496
G +G + Y+ T W A M + A S +++V G G +
Sbjct: 476 GPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVG-----GAMRALYA 530
Query: 497 YSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSN-LSSVEMYDPE 547
YS + D WCL+ + R+ + RLY GG D ++ +++V +DPE
Sbjct: 531 YSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPE 582
Score = 58.2 bits (139), Expect = 2e-08
Identities = 36/130 (27%), Positives = 57/130 (43%), Gaps = 4/130 (3%)
Query: 429 EGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGS 488
+ +Y+SGG + V YN W + R RH LG K++V GG+DG
Sbjct: 376 KNEVYISGGKETQH---DVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGL 432
Query: 489 GFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGY-DGQSNLSSVEMYDPE 547
++ E Y + W P+ S + + +LY +GG +G+ + YDP
Sbjct: 433 QRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPS 492
Query: 548 TDCWTFMAPM 557
T+ W+ A M
Sbjct: 493 TNKWSLKAAM 502
Score = 55.5 bits (132), Expect = 1e-07
Identities = 29/105 (27%), Positives = 53/105 (50%), Gaps = 3/105 (2%)
Query: 456 TWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRS 515
T H K +L +++++ GG + + Y+S ++W I ++ R
Sbjct: 356 TEHELESENKKWVEFACVTLKNEVYISGGKETQHDVW---KYNSSINKWIQIEYLNIGRW 412
Query: 516 RVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMACH 560
R +V G++Y +GG+DG +++VE YDP +CW+ AP+ H
Sbjct: 413 RHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVH 457
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 252 bits (644), Expect = 6e-67
Identities = 172/534 (32%), Positives = 253/534 (47%), Gaps = 26/534 (4%)
Query: 28 MEEIRRQGKLCDVTLKI-GDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDP 86
+ ++R + K DVTL+ G F AHR VLAA+ PYF AMF + E + + + + G+ P
Sbjct: 25 LSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPP 84
Query: 87 SALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQF 146
L+ L++F+Y G +A+ N + LL A LQ ++K+AC FL+++L NCL ++ F
Sbjct: 85 DMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDF 144
Query: 147 AETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAAL 206
AE C+ L AA FI +H E+ +E+ LPL +L + D L V EE ++ AL
Sbjct: 145 AEAFSCSGLASAAQRFILRHVGELG-AEQLERLPLARLLRYLRDDGLCVPKEEAAYQLAL 203
Query: 207 AWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLM 266
WVR D +R + P+LL +RLP R +L V+ + LV C C L+ EA+D+
Sbjct: 204 RWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAA 263
Query: 267 P-ERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTA 325
+R P R RPR T +A ++ VGG + D L V+ ++P W R +
Sbjct: 264 RYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQW---RYLAEF 320
Query: 326 RSRVG----VAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVL 381
+G + + +Y GG DG V YN + W V M R + VL
Sbjct: 321 PDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVL 380
Query: 382 DGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGL 441
DG +YV + S E Y TD W + M+ T GR+Y G G
Sbjct: 381 DGLLYVV-------AADSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGK 433
Query: 442 QIFSSVEHYNHHTATWHPA-AGMLNK-RCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSS 499
+ ++ Y+ T W G L A+L M+ D S + ++Y+
Sbjct: 434 ETM-VMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFV--RDDS---AEVDVYNP 487
Query: 500 VADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSS-VEMYDPETDCWT 552
++W I M+ SL G+LY GGYD LS VE YDPET W+
Sbjct: 488 TRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWS 541
Score = 80.5 bits (197), Expect = 4e-15
Identities = 50/172 (29%), Positives = 77/172 (44%), Gaps = 10/172 (5%)
Query: 385 IYVCGGYDGN-SSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGR-IYVSGGHDGLQ 442
+ + GG D + L +V+ Y+P+T +W + + V G IYV+GG DG +
Sbjct: 288 LVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSR 347
Query: 443 IFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVAD 502
++ V YN W A ML R H ++ L ++V E Y D
Sbjct: 348 LYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAA-------DSTERYDHTTD 400
Query: 503 QWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFM 554
W + PM S A GRLYA+G G+ + ++ YDP+TD W+ +
Sbjct: 401 SWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMV-MQCYDPDTDLWSLV 451
Score = 76.6 bits (187), Expect = 6e-14
Identities = 46/133 (34%), Positives = 65/133 (48%), Gaps = 10/133 (7%)
Query: 284 TSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWER--CRPMTTARSRVGVAVVNGLLYAI 341
T+ G +YA+G L AG V++ +DP + W C + A +NGL+Y +
Sbjct: 418 TACRGRLYAIGSL--AGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFV 475
Query: 342 GGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSV- 400
+ V+ YNP + W ++ SMN VL G++YV GGYD LS V
Sbjct: 476 RDDSAE-----VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVV 530
Query: 401 ETYSPETDKWTVV 413
E Y PET W+VV
Sbjct: 531 EAYDPETRAWSVV 543
Score = 57.4 bits (137), Expect = 4e-08
Identities = 36/98 (36%), Positives = 50/98 (51%), Gaps = 8/98 (8%)
Query: 273 LPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVA 332
LP + P+ T + GL+Y V D V+V++P N W++ M +A
Sbjct: 456 LPPWSFAPKTAT-LNGLMYFVR------DDSAEVDVYNPTRNEWDKIPSMNQVHVGGSLA 508
Query: 333 VVNGLLYAIGGYDGQLRLS-TVEAYNPETDTWTRVGSM 369
V+ G LY GGYD LS VEAY+PET W+ VG +
Sbjct: 509 VLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRL 546
Score = 50.8 bits (120), Expect = 3e-06
Identities = 36/127 (28%), Positives = 50/127 (39%), Gaps = 8/127 (6%)
Query: 432 IYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCR-HGAASLGSKMFVCGGYDGSGF 490
+ V G +V+ YN T W A + + +LG+ ++V GG DGS
Sbjct: 289 VLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRL 348
Query: 491 LSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDC 550
Y+S ++W + PM R S G LY V S E YD TD
Sbjct: 349 YDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAA-------DSTERYDHTTDS 401
Query: 551 WTFMAPM 557
W + PM
Sbjct: 402 WEALQPM 408
Score = 29.6 bits (65), Expect = 7.9
Identities = 15/39 (38%), Positives = 22/39 (56%), Gaps = 1/39 (2%)
Query: 526 LYAVGGYDGQSN-LSSVEMYDPETDCWTFMAPMACHEGG 563
L VGG D + L +V+ Y+P+T W ++A H GG
Sbjct: 288 LVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGG 326
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,962,785
Number of Sequences: 37866
Number of extensions: 883867
Number of successful extensions: 3310
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 174
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 1898
Number of HSP's gapped (non-prelim): 448
length of query: 574
length of database: 18,247,518
effective HSP length: 108
effective length of query: 466
effective length of database: 14,157,990
effective search space: 6597623340
effective search space used: 6597623340
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.