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Search of human proteins with 55743114
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55743114 leucine rich repeat containing 49 [Homo sapiens]
(686 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55743114 leucine rich repeat containing 49 [Homo sapiens] 1351 0.0
gi|239752518 PREDICTED: similar to leucine rich repeat containin... 929 0.0
gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo sap... 116 8e-26
gi|21389483 leucine-rich repeats and guanylate kinase domain con... 102 1e-21
gi|206725447 leucine rich repeat containing 23 isoform a [Homo s... 93 9e-19
gi|42542396 leucine rich repeat containing 23 isoform a [Homo sa... 93 9e-19
gi|157674358 leucine rich repeat containing 50 [Homo sapiens] 92 1e-18
gi|117414162 sodium channel associated protein 2 isoform a [Homo... 82 2e-15
gi|31377705 centrosomal protein 97kDa [Homo sapiens] 80 5e-15
gi|194272228 leucine rich repeat containing 48 isoform b [Homo s... 79 1e-14
gi|194272226 leucine rich repeat containing 48 isoform b [Homo s... 79 1e-14
gi|194272224 leucine rich repeat containing 48 isoform a [Homo s... 79 1e-14
gi|194272222 leucine rich repeat containing 48 isoform a [Homo s... 79 1e-14
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 76 9e-14
gi|31621309 leucine rich repeat containing 6 [Homo sapiens] 76 9e-14
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 75 3e-13
gi|66472382 nischarin [Homo sapiens] 69 1e-11
gi|61966709 leucine rich repeat containing 67 [Homo sapiens] 69 1e-11
gi|120953300 leucine-rich repeats and IQ motif containing 1 isof... 67 5e-11
gi|120953243 leucine-rich repeats and IQ motif containing 1 isof... 67 5e-11
gi|238908508 leucine-rich repeat and death domain-containing pro... 67 7e-11
gi|164607156 axonemal dynein light chain 1 [Homo sapiens] 64 5e-10
gi|33285015 leucine rich repeat containing 28 [Homo sapiens] 64 6e-10
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 62 2e-09
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 62 2e-09
gi|157743290 leucine rich repeat containing 30 [Homo sapiens] 60 5e-09
gi|15529980 leucine rich repeat containing 46 [Homo sapiens] 60 5e-09
gi|71040111 fibromodulin precursor [Homo sapiens] 60 7e-09
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 60 9e-09
gi|5901898 leucine rich repeat containing 23 isoform b [Homo sap... 59 2e-08
>gi|55743114 leucine rich repeat containing 49 [Homo sapiens]
Length = 686
Score = 1351 bits (3496), Expect = 0.0
Identities = 686/686 (100%), Positives = 686/686 (100%)
Query: 1 MIPGKYRSVSGRAANNVNCGLHLVIQTSSLPEKNKVEFKLNKDTSSFPGRLLQHDLERNY 60
MIPGKYRSVSGRAANNVNCGLHLVIQTSSLPEKNKVEFKLNKDTSSFPGRLLQHDLERNY
Sbjct: 1 MIPGKYRSVSGRAANNVNCGLHLVIQTSSLPEKNKVEFKLNKDTSSFPGRLLQHDLERNY 60
Query: 61 SSRQGDHINLVSSSLSSFPILQRSSEEKILYSDRLSLERQKLTVCPIINGEDHLRLLNFQ 120
SSRQGDHINLVSSSLSSFPILQRSSEEKILYSDRLSLERQKLTVCPIINGEDHLRLLNFQ
Sbjct: 61 SSRQGDHINLVSSSLSSFPILQRSSEEKILYSDRLSLERQKLTVCPIINGEDHLRLLNFQ 120
Query: 121 HNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSL 180
HNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSL
Sbjct: 121 HNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSL 180
Query: 181 DVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDV 240
DVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDV
Sbjct: 181 DVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDV 240
Query: 241 DNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLRQ 300
DNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLRQ
Sbjct: 241 DNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLRQ 300
Query: 301 LDMKRITEEERRMASVLAKKEEEKKRESHKQSLLKEKKRLTINNVARQWDLQQQRVANIA 360
LDMKRITEEERRMASVLAKKEEEKKRESHKQSLLKEKKRLTINNVARQWDLQQQRVANIA
Sbjct: 301 LDMKRITEEERRMASVLAKKEEEKKRESHKQSLLKEKKRLTINNVARQWDLQQQRVANIA 360
Query: 361 TNEDRKDSDSPQDPCQIDGSTLSAFPEETGPLDSGLNNALQGLSVIDTYLVEVDGDTLSL 420
TNEDRKDSDSPQDPCQIDGSTLSAFPEETGPLDSGLNNALQGLSVIDTYLVEVDGDTLSL
Sbjct: 361 TNEDRKDSDSPQDPCQIDGSTLSAFPEETGPLDSGLNNALQGLSVIDTYLVEVDGDTLSL 420
Query: 421 YGSGALESLDRNWSVQTAGMITTVSFTFIEFDEIVQVLPKLKIKFPNSLHLKFKETNLVM 480
YGSGALESLDRNWSVQTAGMITTVSFTFIEFDEIVQVLPKLKIKFPNSLHLKFKETNLVM
Sbjct: 421 YGSGALESLDRNWSVQTAGMITTVSFTFIEFDEIVQVLPKLKIKFPNSLHLKFKETNLVM 480
Query: 481 LQQFNALAQLRRIDQLTIDPQGNPVVNFTLWKYYVLFRLSHFSMQKINGTEVTQNDMIMA 540
LQQFNALAQLRRIDQLTIDPQGNPVVNFTLWKYYVLFRLSHFSMQKINGTEVTQNDMIMA
Sbjct: 481 LQQFNALAQLRRIDQLTIDPQGNPVVNFTLWKYYVLFRLSHFSMQKINGTEVTQNDMIMA 540
Query: 541 ERLFGILAHVASSELPQYRLISILGDARKKQFRYLLESKGKKPGIINEENNDSKRLVGEN 600
ERLFGILAHVASSELPQYRLISILGDARKKQFRYLLESKGKKPGIINEENNDSKRLVGEN
Sbjct: 541 ERLFGILAHVASSELPQYRLISILGDARKKQFRYLLESKGKKPGIINEENNDSKRLVGEN 600
Query: 601 TNRATLNYTTRDFYNEKLEEIKEKKKFCKTYIEDLVKEATEINMKNEALQKLWPQMFIEL 660
TNRATLNYTTRDFYNEKLEEIKEKKKFCKTYIEDLVKEATEINMKNEALQKLWPQMFIEL
Sbjct: 601 TNRATLNYTTRDFYNEKLEEIKEKKKFCKTYIEDLVKEATEINMKNEALQKLWPQMFIEL 660
Query: 661 VRDAVIEIRNKNSYMKLCLQQITDQK 686
VRDAVIEIRNKNSYMKLCLQQITDQK
Sbjct: 661 VRDAVIEIRNKNSYMKLCLQQITDQK 686
>gi|239752518 PREDICTED: similar to leucine rich repeat containing
50, partial [Homo sapiens]
Length = 489
Score = 929 bits (2402), Expect = 0.0
Identities = 472/474 (99%), Positives = 473/474 (99%), Gaps = 1/474 (0%)
Query: 179 SLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVR 238
+LDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVR
Sbjct: 4 NLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVR 63
Query: 239 DVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQL 298
DVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQL
Sbjct: 64 DVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQL 123
Query: 299 RQLDMKRITEEERRMASVLAKKEEEKKRESHKQSLLKEKKRLTINNVARQWDLQQQRVAN 358
RQLDMKRITEEERRMASVLAKKEEEKKRESHKQSLLKEKKRLTINNVARQWDLQQ RVAN
Sbjct: 124 RQLDMKRITEEERRMASVLAKKEEEKKRESHKQSLLKEKKRLTINNVARQWDLQQ-RVAN 182
Query: 359 IATNEDRKDSDSPQDPCQIDGSTLSAFPEETGPLDSGLNNALQGLSVIDTYLVEVDGDTL 418
IATNEDRKDSDSPQDPCQIDGSTLSAFPEETGPLDSGLNNALQGLSVIDTYLVEVDGDTL
Sbjct: 183 IATNEDRKDSDSPQDPCQIDGSTLSAFPEETGPLDSGLNNALQGLSVIDTYLVEVDGDTL 242
Query: 419 SLYGSGALESLDRNWSVQTAGMITTVSFTFIEFDEIVQVLPKLKIKFPNSLHLKFKETNL 478
SLYGSGALESLDRNWSVQTAGMITTVSFTFIEFDEIVQVLPKLKIKFPNSLHLKFKETNL
Sbjct: 243 SLYGSGALESLDRNWSVQTAGMITTVSFTFIEFDEIVQVLPKLKIKFPNSLHLKFKETNL 302
Query: 479 VMLQQFNALAQLRRIDQLTIDPQGNPVVNFTLWKYYVLFRLSHFSMQKINGTEVTQNDMI 538
VMLQQFNALAQLRRIDQLTIDPQGNPVVNFTLWKYYVLFRLSHFSMQKINGTEVTQNDMI
Sbjct: 303 VMLQQFNALAQLRRIDQLTIDPQGNPVVNFTLWKYYVLFRLSHFSMQKINGTEVTQNDMI 362
Query: 539 MAERLFGILAHVASSELPQYRLISILGDARKKQFRYLLESKGKKPGIINEENNDSKRLVG 598
MAERLFGILAHVASSELPQYRLISILGDARKKQFRYLLESKGKKPGIINEENNDSKRLVG
Sbjct: 363 MAERLFGILAHVASSELPQYRLISILGDARKKQFRYLLESKGKKPGIINEENNDSKRLVG 422
Query: 599 ENTNRATLNYTTRDFYNEKLEEIKEKKKFCKTYIEDLVKEATEINMKNEALQKL 652
ENTNRATLNYTTRDFYNEKLEEIKEKKKFCKTYIEDLVKEATEINMKNEALQKL
Sbjct: 423 ENTNRATLNYTTRDFYNEKLEEIKEKKKFCKTYIEDLVKEATEINMKNEALQKL 476
Score = 54.7 bits (130), Expect = 3e-07
Identities = 39/125 (31%), Positives = 60/125 (48%), Gaps = 8/125 (6%)
Query: 93 DRLSLERQKLTVCPIINGEDHLRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGL 152
D L L ++T IN LR+LN NF++ + N++ L L L+L NQI + +
Sbjct: 6 DVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDV 65
Query: 153 STLRCLRVLLLGKNRIK---KISNLENLKSLDVLDLHGNQIT-----KIENINHLCELRV 204
L CL+ L L N I +S L + SL + GN I K + ++ +LR
Sbjct: 66 DNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLRQ 125
Query: 205 LNLAR 209
L++ R
Sbjct: 126 LDMKR 130
>gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo
sapiens]
Length = 360
Score = 116 bits (290), Expect = 8e-26
Identities = 63/189 (33%), Positives = 111/189 (58%)
Query: 114 LRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISN 173
L+ L +N I++I+N+SNL +L L+L N+I I + TL L L LGKN+I K+ N
Sbjct: 166 LKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQN 225
Query: 174 LENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQ 233
L+ L +L VL + N++TKIE + +L LR L L+ N + ++ L + LT L++ N+
Sbjct: 226 LDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNR 285
Query: 234 ITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQ 293
I + ++ +L LQ +++ N + S+ + L + SL + + NP+ ++ Y+ V+
Sbjct: 286 IKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVML 345
Query: 294 NMMQLRQLD 302
+ +RQ+D
Sbjct: 346 ALPSVRQID 354
Score = 102 bits (255), Expect = 9e-22
Identities = 77/241 (31%), Positives = 123/241 (51%), Gaps = 17/241 (7%)
Query: 99 RQKLTVCPIINGED--HLRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLR 156
RQ L C I N E+ LR L+ N I +I+N+ L +L LD+ N + I G+ L
Sbjct: 106 RQNLIKC-IENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLT 164
Query: 157 CLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVD 216
L+ L L N+I KI NL NL L +L+L N+I IENI+ L L L L +N ++ +
Sbjct: 165 RLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQ 224
Query: 217 NLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITF 276
NL+ L +LT L+++ N++T + + NL L+ L+LS N I + + L +++ L+ +
Sbjct: 225 NLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGI---EVIEGLENNNKLTMLDI 281
Query: 277 DGNPI-----------AQESWYKHTVLQNMMQLRQLDMKRITEEERRMASVLAKKEEEKK 325
N I QE W +L++ L +L R E + L K + ++
Sbjct: 282 ASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRR 341
Query: 326 R 326
+
Sbjct: 342 K 342
Score = 95.1 bits (235), Expect = 2e-19
Identities = 63/185 (34%), Positives = 101/185 (54%), Gaps = 8/185 (4%)
Query: 117 LNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLEN 176
++ H I +I+ L+K+ +L L N I+ I L L+ LR L L N+IKKI NLE
Sbjct: 81 VDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEA 140
Query: 177 LKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITF 236
L L++LD+ N + IE ++ L L+ L L N +S ++NL+ L L L L N+I
Sbjct: 141 LTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRA 200
Query: 237 VRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMM 296
+ ++D L L+ LFL N I+ ++ L ++L+ ++ N + K LQN++
Sbjct: 201 IENIDTLTNLESLFLGKNKITKLQNLDAL---TNLTVLSMQSNRLT-----KIEGLQNLV 252
Query: 297 QLRQL 301
LR+L
Sbjct: 253 NLREL 257
Score = 90.5 bits (223), Expect = 5e-18
Identities = 71/241 (29%), Positives = 122/241 (50%), Gaps = 14/241 (5%)
Query: 120 QHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKS 179
+H ++ I+ + +DL +I +I G L+ ++ L L +N IK I NLE L+S
Sbjct: 62 EHELPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQS 121
Query: 180 LDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRD 239
L LDL+ NQI KIEN+ L EL +L+++ N L +++ ++ L L +L L +N+I+ + +
Sbjct: 122 LRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIEN 181
Query: 240 VDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLR 299
+ NL LQ L L N I + +++ L + SL F G K T LQN+ L
Sbjct: 182 LSNLHQLQMLELGSNRIRAIENIDTLTNLESL----FLGK-------NKITKLQNLDALT 230
Query: 300 QLDMKRITEEERRMASVLAKKEEEKKRESH-KQSLLKEKKRLTINNVARQWDLQQQRVAN 358
L + ++ + R+ + + RE + + ++ + L NN D+ R+
Sbjct: 231 NLTV--LSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKK 288
Query: 359 I 359
I
Sbjct: 289 I 289
Score = 48.1 bits (113), Expect = 3e-05
Identities = 37/127 (29%), Positives = 62/127 (48%), Gaps = 3/127 (2%)
Query: 69 NLVSSSLSSFPILQRSSEEKILYSDRLSLERQKLTVCPIINGEDHLRLLNFQHNFITRIQ 128
NL S L I + + + + LS++ +LT + +LR L HN I I+
Sbjct: 209 NLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIE 268
Query: 129 NISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLK---SLDVLDL 185
+ N KL LD+ N+I++I +S L L+ + N ++ S+L+ LK SL+ + L
Sbjct: 269 GLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYL 328
Query: 186 HGNQITK 192
N + K
Sbjct: 329 ERNPLQK 335
>gi|21389483 leucine-rich repeats and guanylate kinase domain
containing [Homo sapiens]
Length = 825
Score = 102 bits (254), Expect = 1e-21
Identities = 76/258 (29%), Positives = 127/258 (49%), Gaps = 4/258 (1%)
Query: 54 HDLERNYSSRQGDHINLVSSSLSSFPILQRSSEEKILYSDRLSLERQKLTVCPIINGEDH 113
H L R+ S + ++NL +LS ++ S ++ +L L K+ ++ +
Sbjct: 116 HHLGRSGSGTEQVYLNL---TLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPY 172
Query: 114 LRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISN 173
L LN N +T N + L D NQI EI LS L L+L N I++IS
Sbjct: 173 LLELNASQNNLTTFFNFKPPKNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEISG 232
Query: 174 LENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQ 233
LE +L L L N+IT I +N L +++L L+ N + + L L +L L+L HNQ
Sbjct: 233 LEMCNNLIHLSLANNKITTINGLNKL-PIKILCLSNNQIEMITGLEDLKALQNLDLSHNQ 291
Query: 234 ITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQ 293
I+ ++ ++N L+ + L N I+ + + + L + NPI ++S Y V+
Sbjct: 292 ISSLQGLENHDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENPIQEKSEYWFFVIF 351
Query: 294 NMMQLRQLDMKRITEEER 311
+++L +LD K+I EE+
Sbjct: 352 MLLRLTELDQKKIKVEEK 369
Score = 30.0 bits (66), Expect = 7.4
Identities = 30/128 (23%), Positives = 55/128 (42%), Gaps = 3/128 (2%)
Query: 75 LSSFPILQRSSEEKILYSDRLSLERQKLTVCPIINGEDHLRLLNFQHNFITR---IQNIS 131
LS+ I + E + L L +++ + D L ++N + N I I+ I
Sbjct: 265 LSNNQIEMITGLEDLKALQNLDLSHNQISSLQGLENHDLLEVINLEDNKIAELREIEYIK 324
Query: 132 NLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQIT 191
NL L L+L +N I+E S +L L + KKI E + +++ D +
Sbjct: 325 NLPILRVLNLLENPIQEKSEYWFFVIFMLLRLTELDQKKIKVEEKVSAVNKYDPPPEVVA 384
Query: 192 KIENINHL 199
+++ H+
Sbjct: 385 AQDHLTHV 392
>gi|206725447 leucine rich repeat containing 23 isoform a [Homo
sapiens]
Length = 343
Score = 92.8 bits (229), Expect = 9e-19
Identities = 81/272 (29%), Positives = 129/272 (47%), Gaps = 27/272 (9%)
Query: 94 RLSLERQKLTVCPIINGEDHLRLLNFQHNFITRIQNISNLQKLISL-------------- 139
+L ++ + LT ++ HLR ++ N +T + ++ L L+ L
Sbjct: 73 KLEVKERDLTDIYLLRSYIHLRYVDISENHLTDLSPLNYLTHLLWLKADGNRLRSAQMNE 132
Query: 140 -------DLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNL--ENLKSLDVLDLHGNQI 190
NQI + G+S R L L L N I ++ L E L SL ++L GNQ+
Sbjct: 133 LPYLQIASFAYNQITDTEGISHPR-LETLNLKGNSIHMVTGLDPEKLISLHTVELRGNQL 191
Query: 191 TKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDN-LPCLQHL 249
IN L +L+ L LA+N L V+ L L +LT L+LR NQI + + LQ+L
Sbjct: 192 ESTLGIN-LPKLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDNQIDTLSGFSREMKSLQYL 250
Query: 250 FLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEE 309
L N +++ ++ L D L + NP E+ Y+ L M L +LD + EE
Sbjct: 251 NLRGNMVANLGELAKLRDLPKLRALVLLDNPCTDETSYRQEALVQMPYLERLDKEFYEEE 310
Query: 310 ERRMASVLAKK-EEEKKRESHKQSLLKEKKRL 340
ER A V+ ++ +EEK++E Q L+ ++ L
Sbjct: 311 ERAEADVIRQRLKEEKEQEPEPQRDLEPEQSL 342
>gi|42542396 leucine rich repeat containing 23 isoform a [Homo
sapiens]
Length = 343
Score = 92.8 bits (229), Expect = 9e-19
Identities = 81/272 (29%), Positives = 129/272 (47%), Gaps = 27/272 (9%)
Query: 94 RLSLERQKLTVCPIINGEDHLRLLNFQHNFITRIQNISNLQKLISL-------------- 139
+L ++ + LT ++ HLR ++ N +T + ++ L L+ L
Sbjct: 73 KLEVKERDLTDIYLLRSYIHLRYVDISENHLTDLSPLNYLTHLLWLKADGNRLRSAQMNE 132
Query: 140 -------DLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNL--ENLKSLDVLDLHGNQI 190
NQI + G+S R L L L N I ++ L E L SL ++L GNQ+
Sbjct: 133 LPYLQIASFAYNQITDTEGISHPR-LETLNLKGNSIHMVTGLDPEKLISLHTVELRGNQL 191
Query: 191 TKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDN-LPCLQHL 249
IN L +L+ L LA+N L V+ L L +LT L+LR NQI + + LQ+L
Sbjct: 192 ESTLGIN-LPKLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDNQIDTLSGFSREMKSLQYL 250
Query: 250 FLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEE 309
L N +++ ++ L D L + NP E+ Y+ L M L +LD + EE
Sbjct: 251 NLRGNMVANLGELAKLRDLPKLRALVLLDNPCTDETSYRQEALVQMPYLERLDKEFYEEE 310
Query: 310 ERRMASVLAKK-EEEKKRESHKQSLLKEKKRL 340
ER A V+ ++ +EEK++E Q L+ ++ L
Sbjct: 311 ERAEADVIRQRLKEEKEQEPEPQRDLEPEQSL 342
>gi|157674358 leucine rich repeat containing 50 [Homo sapiens]
Length = 725
Score = 92.4 bits (228), Expect = 1e-18
Identities = 68/208 (32%), Positives = 104/208 (50%), Gaps = 4/208 (1%)
Query: 138 SLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENIN 197
+L L+ + I L LR L L N I+KI NLE L L L N + KIEN+
Sbjct: 111 TLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLE 170
Query: 198 HLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNL-PCLQ--HLFLSFN 254
L +L LNL+ N++ ++NL+ L L L + HN + V D+ +L CL+ L LS N
Sbjct: 171 PLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHN 230
Query: 255 NISSFDSVSCLADSSSLSDITFDGNP-IAQESWYKHTVLQNMMQLRQLDMKRITEEERRM 313
+S + +S L L + GNP I Q Y+ TV + L LD + + ++R
Sbjct: 231 KLSDPEILSILESMPDLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLDDRPVFPKDRAC 290
Query: 314 ASVLAKKEEEKKRESHKQSLLKEKKRLT 341
A A+ ++E +Q +E+K++T
Sbjct: 291 AEAWARGGYAAEKEERQQWESRERKKIT 318
>gi|117414162 sodium channel associated protein 2 isoform a [Homo
sapiens]
Length = 1032
Score = 82.0 bits (201), Expect = 2e-15
Identities = 58/183 (31%), Positives = 94/183 (51%), Gaps = 9/183 (4%)
Query: 143 DNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENINHLCEL 202
D ++ IS LS L + L N I KI ++++ +L LDL NQI++IE +N L +L
Sbjct: 30 DKGLQSISELSLDSTLHAVNLHCNNISKIEAIDHIWNLQHLDLSSNQISRIEGLNTLTKL 89
Query: 203 RVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQH----LFLSFNNISS 258
LNL+ N ++ V+ L L +LT LN+ +N I + + L ++H + L N I S
Sbjct: 90 CTLNLSCNLITKVEGLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDS 149
Query: 259 FDS-VSCLADSSSLSDITF----DGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRM 313
+ C+ L+++ D NP+ + Y+ +LQ + QLR LD K I E +
Sbjct: 150 IHHLLQCMVGLHFLTNLILEKDGDDNPVCRLPGYRAVILQTLPQLRILDCKNIFGEPVNL 209
Query: 314 ASV 316
+
Sbjct: 210 TEI 212
Score = 38.9 bits (89), Expect = 0.016
Identities = 63/266 (23%), Positives = 107/266 (40%), Gaps = 43/266 (16%)
Query: 95 LSLERQKLTVCPIINGEDHLRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLST 154
L L +++ +N L LN N IT+++ + L L L++ N I+++SGL
Sbjct: 70 LDLSSNQISRIEGLNTLTKLCTLNLSCNLITKVEGLEELINLTRLNVSYNHIDDLSGLIP 129
Query: 155 L----RCLRVLLLGKNRIKKISN-LENLKSLDVL-------DLHGNQITKIEN-----IN 197
L LR + L NRI I + L+ + L L D N + ++ +
Sbjct: 130 LHGIKHKLRYIDLHSNRIDSIHHLLQCMVGLHFLTNLILEKDGDDNPVCRLPGYRAVILQ 189
Query: 198 HLCELRVL----------NLARNFLSHVDNLNGL-----DSLTELNLRHNQITFVRDVDN 242
L +LR+L NL S + L GL S + LN+ ++I +D
Sbjct: 190 TLPQLRILDCKNIFGEPVNLTEINSSQLQCLEGLLDNLVSSDSPLNISEDEI-----IDR 244
Query: 243 LPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLD 302
+P + + F S A +S + P E LQN ++L++LD
Sbjct: 245 MPVITAPIDELVPLEQFASTPSDAVLTSFMSVCQSSEP---EKNNHENDLQNEIKLQKLD 301
Query: 303 ---MKRITEEERRMASVLAKKEEEKK 325
++ + E + +VL K K+
Sbjct: 302 DQILQLLNETSNSIDNVLEKDPRPKR 327
>gi|31377705 centrosomal protein 97kDa [Homo sapiens]
Length = 865
Score = 80.5 bits (197), Expect = 5e-15
Identities = 66/220 (30%), Positives = 109/220 (49%), Gaps = 8/220 (3%)
Query: 106 PIINGEDHLRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGK 165
P + E + L N I +++N+ ++LI L + +N++ + G++ L LRVL L
Sbjct: 30 PNLPCEADIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPH 89
Query: 166 NRIKKISNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLT 225
N I + L+ L L+ L+L GN + +E IN L+ L+L+ N +S + +L+ L SL
Sbjct: 90 NSIGCVEGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLVSLK 149
Query: 226 ELNLRHNQITFVRDVD-NLP-CLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQ 283
L L N IT +R LP L L L+ N I + +S LA + L ++ NP
Sbjct: 150 TLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTELEQLSIMNNPCVM 209
Query: 284 ES------WYKHTVLQNMMQLRQLDMKRITEEERRMASVL 317
+ Y+ ++ + LR LD I+++E A L
Sbjct: 210 ATPSIPGFDYRPYIVSWCLNLRVLDGYVISQKESLKAEWL 249
>gi|194272228 leucine rich repeat containing 48 isoform b [Homo
sapiens]
Length = 457
Score = 79.3 bits (194), Expect = 1e-14
Identities = 56/141 (39%), Positives = 78/141 (55%), Gaps = 5/141 (3%)
Query: 82 QRSSEEKILYSDRLSLERQKLTVCPIIN--GEDHLRLLNFQHNFITRIQNISNLQKLISL 139
Q + +E IL+ D LSL+ + I N ++LR L +N I +I+ + NL L+ L
Sbjct: 33 QLAKQEGILFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWL 92
Query: 140 DLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENINHL 199
DL N IE I GL TL L L L NRI KI +L+ L L VL L N+I + NI +L
Sbjct: 93 DLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYL 152
Query: 200 CE---LRVLNLARNFLSHVDN 217
LR L+L+RN +S ++
Sbjct: 153 RRFKCLRTLSLSRNPISEAED 173
Score = 72.8 bits (177), Expect = 1e-12
Identities = 54/197 (27%), Positives = 101/197 (51%), Gaps = 5/197 (2%)
Query: 161 LLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNG 220
L L I +I NL ++L L L N I KIE + +L L L+L+ N + ++ L+
Sbjct: 48 LQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDT 107
Query: 221 LDSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNP 280
L +L +L+L +N+I+ + +D L LQ L L N I + ++ L L ++ NP
Sbjct: 108 LVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNP 167
Query: 281 IAQESWYKHTVLQNMMQLRQLDMKRITEEERRMASVLAKKEEEKKRESHKQSLLKEKKRL 340
I++ YK + + L LD +RI + +++A AK + H+++L++ +
Sbjct: 168 ISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAE--AKHQYSIDELKHQENLMQAQLE- 224
Query: 341 TINNVARQWDLQQQRVA 357
+ A++ +L++ + A
Sbjct: 225 --DEQAQREELEKHKTA 239
>gi|194272226 leucine rich repeat containing 48 isoform b [Homo
sapiens]
Length = 457
Score = 79.3 bits (194), Expect = 1e-14
Identities = 56/141 (39%), Positives = 78/141 (55%), Gaps = 5/141 (3%)
Query: 82 QRSSEEKILYSDRLSLERQKLTVCPIIN--GEDHLRLLNFQHNFITRIQNISNLQKLISL 139
Q + +E IL+ D LSL+ + I N ++LR L +N I +I+ + NL L+ L
Sbjct: 33 QLAKQEGILFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWL 92
Query: 140 DLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENINHL 199
DL N IE I GL TL L L L NRI KI +L+ L L VL L N+I + NI +L
Sbjct: 93 DLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYL 152
Query: 200 CE---LRVLNLARNFLSHVDN 217
LR L+L+RN +S ++
Sbjct: 153 RRFKCLRTLSLSRNPISEAED 173
Score = 72.8 bits (177), Expect = 1e-12
Identities = 54/197 (27%), Positives = 101/197 (51%), Gaps = 5/197 (2%)
Query: 161 LLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNG 220
L L I +I NL ++L L L N I KIE + +L L L+L+ N + ++ L+
Sbjct: 48 LQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDT 107
Query: 221 LDSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNP 280
L +L +L+L +N+I+ + +D L LQ L L N I + ++ L L ++ NP
Sbjct: 108 LVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNP 167
Query: 281 IAQESWYKHTVLQNMMQLRQLDMKRITEEERRMASVLAKKEEEKKRESHKQSLLKEKKRL 340
I++ YK + + L LD +RI + +++A AK + H+++L++ +
Sbjct: 168 ISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAE--AKHQYSIDELKHQENLMQAQLE- 224
Query: 341 TINNVARQWDLQQQRVA 357
+ A++ +L++ + A
Sbjct: 225 --DEQAQREELEKHKTA 239
>gi|194272224 leucine rich repeat containing 48 isoform a [Homo
sapiens]
Length = 523
Score = 79.3 bits (194), Expect = 1e-14
Identities = 56/141 (39%), Positives = 78/141 (55%), Gaps = 5/141 (3%)
Query: 82 QRSSEEKILYSDRLSLERQKLTVCPIIN--GEDHLRLLNFQHNFITRIQNISNLQKLISL 139
Q + +E IL+ D LSL+ + I N ++LR L +N I +I+ + NL L+ L
Sbjct: 33 QLAKQEGILFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWL 92
Query: 140 DLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENINHL 199
DL N IE I GL TL L L L NRI KI +L+ L L VL L N+I + NI +L
Sbjct: 93 DLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYL 152
Query: 200 CE---LRVLNLARNFLSHVDN 217
LR L+L+RN +S ++
Sbjct: 153 RRFKCLRTLSLSRNPISEAED 173
Score = 72.8 bits (177), Expect = 1e-12
Identities = 54/197 (27%), Positives = 101/197 (51%), Gaps = 5/197 (2%)
Query: 161 LLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNG 220
L L I +I NL ++L L L N I KIE + +L L L+L+ N + ++ L+
Sbjct: 48 LQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDT 107
Query: 221 LDSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNP 280
L +L +L+L +N+I+ + +D L LQ L L N I + ++ L L ++ NP
Sbjct: 108 LVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNP 167
Query: 281 IAQESWYKHTVLQNMMQLRQLDMKRITEEERRMASVLAKKEEEKKRESHKQSLLKEKKRL 340
I++ YK + + L LD +RI + +++A AK + H+++L++ +
Sbjct: 168 ISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAE--AKHQYSIDELKHQENLMQAQLE- 224
Query: 341 TINNVARQWDLQQQRVA 357
+ A++ +L++ + A
Sbjct: 225 --DEQAQREELEKHKTA 239
>gi|194272222 leucine rich repeat containing 48 isoform a [Homo
sapiens]
Length = 523
Score = 79.3 bits (194), Expect = 1e-14
Identities = 56/141 (39%), Positives = 78/141 (55%), Gaps = 5/141 (3%)
Query: 82 QRSSEEKILYSDRLSLERQKLTVCPIIN--GEDHLRLLNFQHNFITRIQNISNLQKLISL 139
Q + +E IL+ D LSL+ + I N ++LR L +N I +I+ + NL L+ L
Sbjct: 33 QLAKQEGILFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWL 92
Query: 140 DLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENINHL 199
DL N IE I GL TL L L L NRI KI +L+ L L VL L N+I + NI +L
Sbjct: 93 DLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYL 152
Query: 200 CE---LRVLNLARNFLSHVDN 217
LR L+L+RN +S ++
Sbjct: 153 RRFKCLRTLSLSRNPISEAED 173
Score = 72.8 bits (177), Expect = 1e-12
Identities = 54/197 (27%), Positives = 101/197 (51%), Gaps = 5/197 (2%)
Query: 161 LLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNG 220
L L I +I NL ++L L L N I KIE + +L L L+L+ N + ++ L+
Sbjct: 48 LQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDT 107
Query: 221 LDSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNP 280
L +L +L+L +N+I+ + +D L LQ L L N I + ++ L L ++ NP
Sbjct: 108 LVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNP 167
Query: 281 IAQESWYKHTVLQNMMQLRQLDMKRITEEERRMASVLAKKEEEKKRESHKQSLLKEKKRL 340
I++ YK + + L LD +RI + +++A AK + H+++L++ +
Sbjct: 168 ISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAE--AKHQYSIDELKHQENLMQAQLE- 224
Query: 341 TINNVARQWDLQQQRVA 357
+ A++ +L++ + A
Sbjct: 225 --DEQAQREELEKHKTA 239
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 76.3 bits (186), Expect = 9e-14
Identities = 72/244 (29%), Positives = 123/244 (50%), Gaps = 21/244 (8%)
Query: 68 INLVSSSLSSFPILQRSSEEKILYSDRLSLERQKLTVCPIINGEDHLRLLNFQHNFITRI 127
I+++ SS+ L E LYS++L + V ++N L L N +T +
Sbjct: 112 IHILPSSIKELTQLT----ELYLYSNKL--QSLPAEVGCLVN----LMTLALSENSLTSL 161
Query: 128 -QNISNLQKLISLDLYDNQIEEI-SGLSTLRCLRVLLLGKNRIKKIS-NLENLKSLDVLD 184
++ NL+KL LDL N++ EI S + L L L L NRI + +++NL L +L
Sbjct: 162 PDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLS 221
Query: 185 LHGNQITKIE-NINHLCELRVLNLARNFLSHV-DNLNGLDSLTELNLRHNQITFVRD-VD 241
+ N+I ++ I LC L L++A N L H+ + +T L+L+HN++ + D +
Sbjct: 222 IRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIG 281
Query: 242 NLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLRQL 301
NL L L L +N +S+ LA S+L ++ + N I S ++L ++++L L
Sbjct: 282 NLSSLSRLGLRYNRLSAIP--RSLAKCSALEELNLENNNI---STLPESLLSSLVKLNSL 336
Query: 302 DMKR 305
+ R
Sbjct: 337 TLAR 340
Score = 48.1 bits (113), Expect = 3e-05
Identities = 45/169 (26%), Positives = 78/169 (46%), Gaps = 29/169 (17%)
Query: 68 INLVSSSLSSFPILQRSSEEKILYSDRLSLERQKLTVCPI-INGEDHLRLLNFQHNFITR 126
+N+ + L+S P+ + + L+L +LT P ++G L +L +N + +
Sbjct: 384 LNMKDNQLTSLPLDFGTWTSMV----ELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKK 439
Query: 127 IQN-ISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDL 185
+ + + NL+KL LDL +N++E + + + LK L L L
Sbjct: 440 LPHGLGNLRKLRELDLEENKLESLP---------------------NEIAYLKDLQKLVL 478
Query: 186 HGNQITKI-ENINHLCELRVLNLARNFLSHV-DNLNGLDSLTELNLRHN 232
NQ+T + I HL L L L N L+H+ + + L++L EL L N
Sbjct: 479 TNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDN 527
>gi|31621309 leucine rich repeat containing 6 [Homo sapiens]
Length = 466
Score = 76.3 bits (186), Expect = 9e-14
Identities = 51/161 (31%), Positives = 79/161 (49%), Gaps = 1/161 (0%)
Query: 179 SLDVLDLHGNQITKIENINHLC-ELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFV 237
SL+ L LH +I ++E+I+ C +L++L L N + ++N++ L L LNL N I +
Sbjct: 22 SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI 81
Query: 238 RDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQ 297
+++ L L L+ N I S+ L + L ++ GNP A Y+ V+ + Q
Sbjct: 82 ENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQ 141
Query: 298 LRQLDMKRITEEERRMASVLAKKEEEKKRESHKQSLLKEKK 338
L+ LD K I ER A E + RE K LK K
Sbjct: 142 LKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAK 182
Score = 48.1 bits (113), Expect = 3e-05
Identities = 77/346 (22%), Positives = 145/346 (41%), Gaps = 29/346 (8%)
Query: 80 ILQRSSEEK--ILYS-DRLSLERQKLTVCPIINGEDH-LRLLNFQHNFITRIQNISNLQK 135
+++R++E +++S + LSL +Q++ I+ L++L Q+N I +I+N+S L+K
Sbjct: 8 LIRRNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKK 67
Query: 136 LISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLK---SLDVLDLHGNQITK 192
L L+L N IE+I L L L L N I ++S+++NL+ L L L GN
Sbjct: 68 LEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCAS 127
Query: 193 IENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLFLS 252
++ + L ++ + +L + ++ QI R+ + CL+ L
Sbjct: 128 FDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQI---REQEKDHCLKRAKLK 184
Query: 253 FNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERR 312
+ S+ FDG WY + + L D + + E
Sbjct: 185 EEAQRKHQEED--KNEDKRSNAGFDGR------WYT-DINATLSSLESKDHLQAPDTEEH 235
Query: 313 MASVLAKKEEEKKRESHKQSLLKEKKRLTINNVARQWDLQQQRVANIATNEDRKDSDSPQ 372
L E++ + + E + T+ ++ +Q Q++ +E +K P+
Sbjct: 236 NTKKLDNSEDDLEFWNKPCLFTPESRLETLRHMEKQRKKQEK------LSEKKKKVKPPR 289
Query: 373 DPCQIDGSTLSA-FPEETGPLDSGLNNALQGLSV---IDTYLVEVD 414
DG L+ P+ L + L+V +DT L++VD
Sbjct: 290 TLITEDGKALNVNEPKIDFSLKDNEKQIILDLAVYRYMDTSLIDVD 335
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 74.7 bits (182), Expect = 3e-13
Identities = 56/203 (27%), Positives = 95/203 (46%), Gaps = 2/203 (0%)
Query: 164 GKNRIKKISNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDS 223
G + K I NLE L+VL+L N I KIE ++ L +LR LNL+ N +S ++ + + +
Sbjct: 111 GGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCN 170
Query: 224 LTELNLRHNQITFVRD--VDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPI 281
L +LNL N+I + L L+ L L N ISS +S L L + NP+
Sbjct: 171 LQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPV 230
Query: 282 AQESWYKHTVLQNMMQLRQLDMKRITEEERRMASVLAKKEEEKKRESHKQSLLKEKKRLT 341
Y + ++ L L+ + +T ++R+ A EE ++ E + + E + L
Sbjct: 231 VTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELK 290
Query: 342 INNVARQWDLQQQRVANIATNED 364
+++ Q N + E+
Sbjct: 291 SKQTRFLEEIKNQDKLNKSLKEE 313
>gi|66472382 nischarin [Homo sapiens]
Length = 1504
Score = 69.3 bits (168), Expect = 1e-11
Identities = 48/133 (36%), Positives = 74/133 (55%), Gaps = 5/133 (3%)
Query: 130 ISNLQKLISLDLYDNQIEEIS-GLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGN 188
I Q L +LDL N I EI + + + L L N + + NL++L +L LDL N
Sbjct: 283 IPTWQALTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYN 342
Query: 189 QITKIENIN-HLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHN---QITFVRDVDNLP 244
+++ +E ++ L ++ LNLA N L + L+ L SL L+LR N Q+ VR + +LP
Sbjct: 343 KLSSLEGLHTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLP 402
Query: 245 CLQHLFLSFNNIS 257
CL+H+ L N +S
Sbjct: 403 CLEHVSLLNNPLS 415
Score = 52.0 bits (123), Expect = 2e-06
Identities = 34/107 (31%), Positives = 54/107 (50%), Gaps = 8/107 (7%)
Query: 114 LRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLST-LRCLRVLLLGKNRIKKIS 172
+ L+ HN + + N+ +L L+ LDL N++ + GL T L ++ L L N ++ +S
Sbjct: 312 IEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESLS 371
Query: 173 NLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLN 219
L L SL LDL N+I ++E + + L L HV LN
Sbjct: 372 GLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPC-------LEHVSLLN 411
Score = 36.6 bits (83), Expect = 0.079
Identities = 43/189 (22%), Positives = 75/189 (39%), Gaps = 24/189 (12%)
Query: 113 HLRLLNFQHNFITRIQNISNLQKLISLDLYDN---QIEEISGLSTLRCLRVLLLGKN--- 166
+++ LN N + + + L L++LDL DN Q+EE+ + +L CL + L N
Sbjct: 356 NIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLS 415
Query: 167 -----RIKKISNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGL 221
R K ++ S LD +++ + L ++ ++ LS+ + G
Sbjct: 416 IIPDYRTKVLAQFGERASEVCLDDTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKGGE 475
Query: 222 DSLTELNLRHNQITFVRDVDNLP-------CLQHLFLSFNNISSFDSVSCLADSSSLSDI 274
DS R + +R + P L LS I + + SS +
Sbjct: 476 DS------RLSAAPCIRPSSSPPTVAPASASLPQPILSNQGIMFVQEEALASSLSSTDSL 529
Query: 275 TFDGNPIAQ 283
T + PIAQ
Sbjct: 530 TPEHQPIAQ 538
Score = 35.8 bits (81), Expect = 0.14
Identities = 20/62 (32%), Positives = 37/62 (59%), Gaps = 1/62 (1%)
Query: 202 LRVLNLARNFLSHVD-NLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFD 260
L L+L+ N +S +D ++ + + L+L HN + V ++ +L L HL LS+N +SS +
Sbjct: 289 LTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLE 348
Query: 261 SV 262
+
Sbjct: 349 GL 350
>gi|61966709 leucine rich repeat containing 67 [Homo sapiens]
Length = 228
Score = 68.9 bits (167), Expect = 1e-11
Identities = 59/185 (31%), Positives = 86/185 (46%), Gaps = 9/185 (4%)
Query: 117 LNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLEN 176
+NF I I+++S + L L LYDN I +I+ L+ L L L N I I NL +
Sbjct: 33 INFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRS 92
Query: 177 LKSLDVLDLHGNQITKIENINHLCELRVLN-------LARNFLSHVDNLNGL-DSLTELN 228
LK L+ L L GN I IE + L ELR L+ L L L+ L SL LN
Sbjct: 93 LKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILN 152
Query: 229 LRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADS-SSLSDITFDGNPIAQESWY 287
+ +N I + D++ L L L N + + L + L I +GNP+ + Y
Sbjct: 153 ISNNNIDDITDLELLENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGNPVCLKPKY 212
Query: 288 KHTVL 292
+ ++
Sbjct: 213 RDRLI 217
Score = 58.9 bits (141), Expect = 1e-08
Identities = 43/145 (29%), Positives = 72/145 (49%), Gaps = 11/145 (7%)
Query: 133 LQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITK 192
L+K+ ++ D I+ I LS + L VL L N I +I+NL +L L L N I+
Sbjct: 27 LKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISC 86
Query: 193 IENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLFLS 252
IEN+ L +L L L N+++ ++ L GL L EL++ + + LP + L
Sbjct: 87 IENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQR---------LPLGEKLLFD 137
Query: 253 FNNISSFDSVSCLAD--SSSLSDIT 275
+ S C+ + ++++ DIT
Sbjct: 138 PRTLHSLAKSLCILNISNNNIDDIT 162
Score = 48.5 bits (114), Expect = 2e-05
Identities = 54/180 (30%), Positives = 82/180 (45%), Gaps = 17/180 (9%)
Query: 67 HINLVSSSLSSFPILQRSSEEKILYSDRLSLERQKLTVCPIINGEDHLRLLNFQHNFITR 126
HIN ++ + L +LY L ++ +N +L L Q+N I+
Sbjct: 32 HINFSDKNIDAIEDLSLCKNLSVLY-----LYDNCISQITNLNYATNLTHLYLQNNCISC 86
Query: 127 IQNISNLQKLISLDLYDNQ---IEEISGLSTLRCLRV----LLLGKNRIKKISNLENL-K 178
I+N+ +L+KL L L N IE + GL LR L V L LG+ + L +L K
Sbjct: 87 IENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAK 146
Query: 179 SLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDN----LNGLDSLTELNLRHNQI 234
SL +L++ N I I ++ L L L N L HV + LN L L +++L N +
Sbjct: 147 SLCILNISNNNIDDITDLELLENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGNPV 206
>gi|120953300 leucine-rich repeats and IQ motif containing 1 isoform 1
[Homo sapiens]
Length = 1722
Score = 67.0 bits (162), Expect = 5e-11
Identities = 49/179 (27%), Positives = 93/179 (51%), Gaps = 6/179 (3%)
Query: 127 IQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLH 186
++++ NLQ+LI L NQ+ GL + L N + + +EN L +L L
Sbjct: 965 LESLKNLQQLI---LDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQ 1021
Query: 187 GNQITKIENINHLCELRVLNLARNFLSHVDNLNG--LDSLTELNLRHNQITFVRDVDNLP 244
GN ++++ ++ +L LR L+L N +S V+ + L L + + N +T + + +
Sbjct: 1022 GNYLSELPSLENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKIVPLFHFV 1081
Query: 245 CLQHLFLSFNNISSFDSVSCLADSS-SLSDITFDGNPIAQESWYKHTVLQNMMQLRQLD 302
L+ L +S N +S S D+ SL +++ GNP+ QE+ ++ ++L+ + LR L+
Sbjct: 1082 SLEKLDVSHNCLSDLKSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLKVLPALRILN 1140
Score = 51.2 bits (121), Expect = 3e-06
Identities = 58/233 (24%), Positives = 104/233 (44%), Gaps = 51/233 (21%)
Query: 113 HLRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKIS 172
+L+ L+ + +T + ++SN +KL +D +N IE I L L V+LL KN++ +
Sbjct: 819 NLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIE-CENLENLCVVLLNKNQLTSLH 877
Query: 173 NLENLKSLDVLDLHGNQITKIENINHLCELRV---------------LNLAR-------- 209
L+ ++ L+L N+IT+I L E V L+LA+
Sbjct: 878 GLDGCTNIQCLELSYNKITRIGYSFFLEEKLVDNAGFCHHLGTSTSYLSLAQVWIPTGLC 937
Query: 210 ---------------NFL-SHV---DNLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLF 250
NFL SH+ L L +L +L L HNQ+ + + + P + +L
Sbjct: 938 WSWIPITSLTKNSDCNFLISHLYWNCGLESLKNLQQLILDHNQLINTKGLCDTPTIVYLD 997
Query: 251 LSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDM 303
S N+++ + V + L + GN +++ L+N++ LR+L +
Sbjct: 998 CSHNHLTDVEGVE---NCGLLQILKLQGNYLSE-----LPSLENLVLLRELHL 1042
Score = 40.8 bits (94), Expect = 0.004
Identities = 24/84 (28%), Positives = 47/84 (55%), Gaps = 2/84 (2%)
Query: 114 LRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLST--LRCLRVLLLGKNRIKKI 171
L++L Q N+++ + ++ NL L L L DN I + S+ L L+ + + +N + KI
Sbjct: 1015 LQILKLQGNYLSELPSLENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKI 1074
Query: 172 SNLENLKSLDVLDLHGNQITKIEN 195
L + SL+ LD+ N ++ +++
Sbjct: 1075 VPLFHFVSLEKLDVSHNCLSDLKS 1098
Score = 35.8 bits (81), Expect = 0.14
Identities = 22/87 (25%), Positives = 46/87 (52%), Gaps = 1/87 (1%)
Query: 171 ISNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLR 230
+S L +L L L +T + ++++ +L+ ++ N + ++ N L++L + L
Sbjct: 811 LSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIECEN-LENLCVVLLN 869
Query: 231 HNQITFVRDVDNLPCLQHLFLSFNNIS 257
NQ+T + +D +Q L LS+N I+
Sbjct: 870 KNQLTSLHGLDGCTNIQCLELSYNKIT 896
>gi|120953243 leucine-rich repeats and IQ motif containing 1 isoform 2
[Homo sapiens]
Length = 1336
Score = 67.0 bits (162), Expect = 5e-11
Identities = 49/179 (27%), Positives = 93/179 (51%), Gaps = 6/179 (3%)
Query: 127 IQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLH 186
++++ NLQ+LI L NQ+ GL + L N + + +EN L +L L
Sbjct: 965 LESLKNLQQLI---LDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQ 1021
Query: 187 GNQITKIENINHLCELRVLNLARNFLSHVDNLNG--LDSLTELNLRHNQITFVRDVDNLP 244
GN ++++ ++ +L LR L+L N +S V+ + L L + + N +T + + +
Sbjct: 1022 GNYLSELPSLENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKIVPLFHFV 1081
Query: 245 CLQHLFLSFNNISSFDSVSCLADSS-SLSDITFDGNPIAQESWYKHTVLQNMMQLRQLD 302
L+ L +S N +S S D+ SL +++ GNP+ QE+ ++ ++L+ + LR L+
Sbjct: 1082 SLEKLDVSHNCLSDLKSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLKVLPALRILN 1140
Score = 51.2 bits (121), Expect = 3e-06
Identities = 58/233 (24%), Positives = 104/233 (44%), Gaps = 51/233 (21%)
Query: 113 HLRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKIS 172
+L+ L+ + +T + ++SN +KL +D +N IE I L L V+LL KN++ +
Sbjct: 819 NLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIE-CENLENLCVVLLNKNQLTSLH 877
Query: 173 NLENLKSLDVLDLHGNQITKIENINHLCELRV---------------LNLAR-------- 209
L+ ++ L+L N+IT+I L E V L+LA+
Sbjct: 878 GLDGCTNIQCLELSYNKITRIGYSFFLEEKLVDNAGFCHHLGTSTSYLSLAQVWIPTGLC 937
Query: 210 ---------------NFL-SHV---DNLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLF 250
NFL SH+ L L +L +L L HNQ+ + + + P + +L
Sbjct: 938 WSWIPITSLTKNSDCNFLISHLYWNCGLESLKNLQQLILDHNQLINTKGLCDTPTIVYLD 997
Query: 251 LSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDM 303
S N+++ + V + L + GN +++ L+N++ LR+L +
Sbjct: 998 CSHNHLTDVEGVE---NCGLLQILKLQGNYLSE-----LPSLENLVLLRELHL 1042
Score = 40.8 bits (94), Expect = 0.004
Identities = 24/84 (28%), Positives = 47/84 (55%), Gaps = 2/84 (2%)
Query: 114 LRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLST--LRCLRVLLLGKNRIKKI 171
L++L Q N+++ + ++ NL L L L DN I + S+ L L+ + + +N + KI
Sbjct: 1015 LQILKLQGNYLSELPSLENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKI 1074
Query: 172 SNLENLKSLDVLDLHGNQITKIEN 195
L + SL+ LD+ N ++ +++
Sbjct: 1075 VPLFHFVSLEKLDVSHNCLSDLKS 1098
Score = 35.8 bits (81), Expect = 0.14
Identities = 22/87 (25%), Positives = 46/87 (52%), Gaps = 1/87 (1%)
Query: 171 ISNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLR 230
+S L +L L L +T + ++++ +L+ ++ N + ++ N L++L + L
Sbjct: 811 LSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIECEN-LENLCVVLLN 869
Query: 231 HNQITFVRDVDNLPCLQHLFLSFNNIS 257
NQ+T + +D +Q L LS+N I+
Sbjct: 870 KNQLTSLHGLDGCTNIQCLELSYNKIT 896
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 66.6 bits (161), Expect = 7e-11
Identities = 78/263 (29%), Positives = 131/263 (49%), Gaps = 17/263 (6%)
Query: 8 SVSGRAANN---VNCGLHLVIQTSS--LPEKNKVEFKLNKD--TSSFPGRLLQHDLERNY 60
S++GR A VN H + S + E+N+ + L D T + + LQ +
Sbjct: 102 SLTGRTAEYQALVNFLSHETVGEVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDIL 161
Query: 61 SSRQGDHINLVSSSLSSFPILQRSSEEKILYSDRLSLERQKLTVCPI-INGEDHLRLLNF 119
+ ++ L + + +F Q + +L + LSL+ L+ P I +LR+LN
Sbjct: 162 KIKYVKYLYLDKNQIKTF---QGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNV 218
Query: 120 QHNFITRI-QNISNLQKLISLDLYDNQIEEI-SGLSTLRCLRVLLLGKNRIKKI-SNLEN 176
HN I+ I + IS L + L Y+N IE S L L L +L LGKN+++ I L +
Sbjct: 219 SHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPS 278
Query: 177 LKSLDVLDLHGNQITKI-ENINHLCELRVLNLARNFLSHV-DNLNGLDSLTELNLRHNQI 234
LK+L VL+L NQ+T + + L +L L+L N +S + + L +L L + HN++
Sbjct: 279 LKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKL 338
Query: 235 TFVR-DVDNLPCLQHLFLSFNNI 256
TF+ ++ L ++ L L+ N +
Sbjct: 339 TFLAVEIFQLLKIKELQLADNKL 361
Score = 61.6 bits (148), Expect = 2e-09
Identities = 45/169 (26%), Positives = 97/169 (57%), Gaps = 10/169 (5%)
Query: 121 HNFITRIQNISNLQKLISLDLYDNQIEEISG-LSTLRCLRVLLLGKNRI----KKISNLE 175
+ F T + + L+ L LDL +NQ+++IS + L+ ++ L N+ ++ L+
Sbjct: 566 NKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQ 625
Query: 176 NLKSLDVLDLHGNQITKIE-NINHLCELRVLNLARNFLSHVD-NLNGLDSLTELNLRHNQ 233
+L+ L++ + G ++T++ ++++ +L+ L+++ N + + N+ L +L L+ +NQ
Sbjct: 626 SLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQ 685
Query: 234 ITFV-RDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPI 281
I+++ + +L LQ L LS NN+++ S + + SL +I FD NP+
Sbjct: 686 ISYLPPSLLSLNDLQQLNLSGNNLTALP--SAIYNIFSLKEINFDDNPL 732
Score = 49.3 bits (116), Expect = 1e-05
Identities = 53/166 (31%), Positives = 90/166 (54%), Gaps = 7/166 (4%)
Query: 94 RLSLERQKLTVCPI-INGEDHLRLLNFQHNFITRIQ-NISNLQKLISLDLYDNQIEEISG 151
++ L K+ P+ + D L L+ N+I+ I +IS ++L+ L+L +N++ S
Sbjct: 468 KIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSE 527
Query: 152 -LSTLRCLRVLLLGKNRIKKI-SNLENLKSLDVLDLHGNQI-TKIENINHLCELRVLNLA 208
+L L+ L LGKN+IKKI +++ N+ SL VL L N+ T + L L+VL+L+
Sbjct: 528 HFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLS 587
Query: 209 RNFLSHV-DNLNGLDSLTELNLRHNQ-ITFVRDVDNLPCLQHLFLS 252
N L + ++ L + +LN NQ I F ++ L L+ L +S
Sbjct: 588 ENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNIS 633
Score = 42.7 bits (99), Expect = 0.001
Identities = 39/156 (25%), Positives = 72/156 (46%), Gaps = 30/156 (19%)
Query: 155 LRCLRVLLLGKNRIKKISNLEN--LKSLDVLDLHGNQITKIEN-INHLCELRVLNLARNF 211
++ ++ L L KN+IK ++ L L++L L N ++ + + I L LR+LN++ N
Sbjct: 163 IKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNH 222
Query: 212 LSHV------------------------DNLNGLDSLTELNLRHNQITFVRD-VDNLPCL 246
+SH+ +L L +L L+L N++ + D + +L L
Sbjct: 223 ISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTL 282
Query: 247 QHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIA 282
+ L L +N +++F C D+T GN I+
Sbjct: 283 RVLNLEYNQLTTFPKALCFLPKLISLDLT--GNLIS 316
Score = 38.1 bits (87), Expect = 0.027
Identities = 39/131 (29%), Positives = 66/131 (50%), Gaps = 9/131 (6%)
Query: 68 INLVSSSLSSFPI--LQRSSEEKILYSDRLSLERQKLTVCP-IINGEDHLRLLNFQHNFI 124
+N S+ FPI Q S E++ S ++ +KLT P ++ L+ L+ +N I
Sbjct: 607 LNFSSNQFIHFPIELCQLQSLEQLNISQ---IKGRKLTRLPGELSNMTQLKELDISNNAI 663
Query: 125 TRI-QNISNLQKLISLDLYDNQIEEI-SGLSTLRCLRVLLLGKNRIKKI-SNLENLKSLD 181
I +NI L+ L+SL Y+NQI + L +L L+ L L N + + S + N+ SL
Sbjct: 664 REIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLK 723
Query: 182 VLDLHGNQITK 192
++ N + +
Sbjct: 724 EINFDDNPLLR 734
>gi|164607156 axonemal dynein light chain 1 [Homo sapiens]
Length = 190
Score = 63.9 bits (154), Expect = 5e-10
Identities = 49/160 (30%), Positives = 85/160 (53%), Gaps = 14/160 (8%)
Query: 169 KKISNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGL----DSL 224
K ++L L + + L L N I KI N+N L LR+L+L RN ++ NLNGL D+L
Sbjct: 39 KMDASLSMLANCEKLSLSTNCIEKIANLNGLKNLRILSLGRN---NIKNLNGLEAVGDTL 95
Query: 225 TELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQE 284
EL + +N I ++ + + L+ L++S N + + LA+ L D+ F GNP+ +
Sbjct: 96 EELWISYNFIEKLKGIHIMKKLKILYMSNNLVKDWAEFVKLAELPCLEDLVFVGNPLEE- 154
Query: 285 SWYKHTVLQNMMQLRQLDMKRITEEERRMASVLAKKEEEK 324
KH+ N ++ KR+ + ++ + + K +EE+
Sbjct: 155 ---KHSAENNWIEEA---TKRVPKLKKLDGTPVIKGDEEE 188
Score = 47.8 bits (112), Expect = 3e-05
Identities = 29/85 (34%), Positives = 53/85 (62%), Gaps = 1/85 (1%)
Query: 129 NISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENL-KSLDVLDLHG 187
++S L L L N IE+I+ L+ L+ LR+L LG+N IK ++ LE + +L+ L +
Sbjct: 43 SLSMLANCEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLEAVGDTLEELWISY 102
Query: 188 NQITKIENINHLCELRVLNLARNFL 212
N I K++ I+ + +L++L ++ N +
Sbjct: 103 NFIEKLKGIHIMKKLKILYMSNNLV 127
Score = 35.0 bits (79), Expect = 0.23
Identities = 23/93 (24%), Positives = 45/93 (48%), Gaps = 1/93 (1%)
Query: 93 DRLSLERQKLTVCPIINGEDHLRLLNFQHNFITRIQNISNL-QKLISLDLYDNQIEEISG 151
++LSL + +NG +LR+L+ N I + + + L L + N IE++ G
Sbjct: 51 EKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLEAVGDTLEELWISYNFIEKLKG 110
Query: 152 LSTLRCLRVLLLGKNRIKKISNLENLKSLDVLD 184
+ ++ L++L + N +K + L L L+
Sbjct: 111 IHIMKKLKILYMSNNLVKDWAEFVKLAELPCLE 143
>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
Length = 367
Score = 63.5 bits (153), Expect = 6e-10
Identities = 63/205 (30%), Positives = 106/205 (51%), Gaps = 12/205 (5%)
Query: 62 SRQGDHINLVSS--SLSSFPILQRSSEEKILYSDRLSLERQKLTVCPIINGEDHLRLLNF 119
+R H NL + +L FP L+ +E + Y +RL ++R LT P + L+
Sbjct: 12 ARLEKHKNLFLNYRNLHHFP-LELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVEL 70
Query: 120 ---QHNFITRIQNISNLQKLISLDLYDNQIEEI-SGLSTLRCLRVLLLGKNRIKKI-SNL 174
+N + + I +L KL LDL DN +E + + LR LR L L N+++ + +
Sbjct: 71 YLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEV 130
Query: 175 ENLKSLDVLDLHGNQITKIENINHLC-ELRVLNLARNFLSHVD-NLNGLDSLTELNLRHN 232
+LK L LD+ N++ + H+C L+ L + RN L +V +L L SL EL++ N
Sbjct: 131 GDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLNELSMAGN 190
Query: 233 QITFV-RDVDNLPCLQHLFLSFNNI 256
++ F+ D+ LQ++++ NNI
Sbjct: 191 RLAFLPLDLGRSRELQYVYVD-NNI 214
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 61.6 bits (148), Expect = 2e-09
Identities = 59/203 (29%), Positives = 104/203 (51%), Gaps = 15/203 (7%)
Query: 117 LNFQHNFITRIQ--NISNLQKLISLDLYDNQIEEISGLSTLRC-LRVLLLGKNRIKKI-- 171
L+ HN ++ I+ ++S+LQ L + L +N++E I L + + +L L NRI +I
Sbjct: 79 LDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILP 138
Query: 172 SNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLS-----HVDNLNGLDSLTE 226
+L+ +SL+ LDL N I++++ +L+ L L N ++ + DNL ++L
Sbjct: 139 EHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNL--ANTLLV 196
Query: 227 LNLRHNQITFVRD-VDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQES 285
L L N+I+ + + LP LQHL L+ N I + D ++ +L + N + +
Sbjct: 197 LKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLT-FQGLGALKSLKMQRNGVTKLM 255
Query: 286 WYKHTVLQNMMQLRQLDMKRITE 308
L N M++ QLD +TE
Sbjct: 256 DGAFWGLSN-MEILQLDHNNLTE 277
Score = 50.4 bits (119), Expect = 5e-06
Identities = 50/160 (31%), Positives = 79/160 (49%), Gaps = 20/160 (12%)
Query: 113 HLRLLNFQHNFITRI--QNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKK 170
++ LL+ N I I +++ Q L +LDL N I E+ L+ L L NR+
Sbjct: 122 NITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTS 181
Query: 171 I-----SNLENLKSLDVLDLHGNQITKI-ENINHLCELRVLNLARNFLSHVDNL--NGLD 222
+ NL N +L VL L+ N+I+ I + L +L+ L L RN + +VD L GL
Sbjct: 182 MEPGYFDNLAN--TLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLG 239
Query: 223 SLTELNLRHNQITFVRD-----VDNLPCLQHLFLSFNNIS 257
+L L ++ N +T + D + N+ LQ L NN++
Sbjct: 240 ALKSLKMQRNGVTKLMDGAFWGLSNMEILQ---LDHNNLT 276
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 61.6 bits (148), Expect = 2e-09
Identities = 59/207 (28%), Positives = 105/207 (50%), Gaps = 15/207 (7%)
Query: 113 HLRLLNFQHNFITRIQ--NISNLQKLISLDLYDNQIEEISGLSTLRC-LRVLLLGKNRIK 169
H+ + HN ++ I+ ++S+LQ L + L +N++E I L + + +L L NRI
Sbjct: 15 HISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIV 74
Query: 170 KI--SNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLS-----HVDNLNGLD 222
+I +L+ +SL+ LDL N I++++ +L+ L L N ++ + DNL +
Sbjct: 75 EILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNL--AN 132
Query: 223 SLTELNLRHNQITFVRD-VDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPI 281
+L L L N+I+ + + LP LQHL L+ N I + D ++ +L + N +
Sbjct: 133 TLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLT-FQGLGALKSLKMQRNGV 191
Query: 282 AQESWYKHTVLQNMMQLRQLDMKRITE 308
+ L N M++ QLD +TE
Sbjct: 192 TKLMDGAFWGLSN-MEILQLDHNNLTE 217
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/207 (28%), Positives = 95/207 (45%), Gaps = 21/207 (10%)
Query: 67 HINLVSSSLSSFPILQRSSEEKILYSDRLSLERQKLTVCPIINGED-HLRLLNFQHNFIT 125
HI+ S + ++ SS + + L +L P + ++ LL+ N I
Sbjct: 15 HISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIV 74
Query: 126 RI--QNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKI-----SNLENLK 178
I +++ Q L +LDL N I E+ L+ L L NR+ + NL N
Sbjct: 75 EILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLAN-- 132
Query: 179 SLDVLDLHGNQITKI-ENINHLCELRVLNLARNFLSHVDNL--NGLDSLTELNLRHNQIT 235
+L VL L+ N+I+ I + L +L+ L L RN + +VD L GL +L L ++ N +T
Sbjct: 133 TLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVT 192
Query: 236 FVRD-----VDNLPCLQHLFLSFNNIS 257
+ D + N+ LQ L NN++
Sbjct: 193 KLMDGAFWGLSNMEILQ---LDHNNLT 216
>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
Length = 301
Score = 60.5 bits (145), Expect = 5e-09
Identities = 53/199 (26%), Positives = 99/199 (49%), Gaps = 7/199 (3%)
Query: 83 RSSEEKILYSDRLSLERQKLTVCP-IINGEDHLRLLNFQHNFITRIQ-NISNLQKLISLD 140
RS ++ ++ SL + +T P + G ++ LN HN + + + L +++ L+
Sbjct: 41 RSLLKRGMHHVSFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLN 100
Query: 141 LYDNQIEEISG-LSTLRCLRVLLLGKNRIKKI-SNLENLKSLDVLDLHGNQITKIEN-IN 197
L N+++ + +S L+CL+VL + N + ++ + L + L+VL L N ++++
Sbjct: 101 LCGNRLKSLPREVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFA 160
Query: 198 HLCELRVLNLARNFLSHVDN-LNGLDSLTELNLRHNQI-TFVRDVDNLPCLQHLFLSFNN 255
L LR LNL+ NF +H+ + L L L++ N++ + +L LQ NN
Sbjct: 161 DLSRLRKLNLSNNFFAHIPMCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNN 220
Query: 256 ISSFDSVSCLADSSSLSDI 274
I SF CL S L ++
Sbjct: 221 IHSFPRSLCLVTSLELLNL 239
>gi|15529980 leucine rich repeat containing 46 [Homo sapiens]
Length = 321
Score = 60.5 bits (145), Expect = 5e-09
Identities = 38/110 (34%), Positives = 58/110 (52%)
Query: 112 DHLRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKI 171
D L+ + IT I+N+ LQ L SL L N+I++I L+ + LR L L N+I+++
Sbjct: 44 DELQTVRLDREGITTIRNLEGLQNLHSLYLQGNKIQQIENLACIPSLRFLSLAGNQIRQV 103
Query: 172 SNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGL 221
NL +L L LDL N I ++ L +LNL+ N ++ D L
Sbjct: 104 ENLLDLPCLQFLDLSENLIETLKLDEFPQSLLILNLSGNSCTNQDGYREL 153
Score = 58.9 bits (141), Expect = 1e-08
Identities = 48/134 (35%), Positives = 70/134 (52%), Gaps = 3/134 (2%)
Query: 154 TLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLS 213
TL L+ + L + I I NLE L++L L L GN+I +IEN+ + LR L+LA N +
Sbjct: 42 TLDELQTVRLDREGITTIRNLEGLQNLHSLYLQGNKIQQIENLACIPSLRFLSLAGNQIR 101
Query: 214 HVDNLNGLDSLTELNLRHNQITFVRDVDNLP-CLQHLFLSFNNISSFDSVSCLADSSSLS 272
V+NL L L L+L N I ++ +D P L L LS N+ ++ D L +
Sbjct: 102 QVENLLDLPCLQFLDLSENLIETLK-LDEFPQSLLILNLSGNSCTNQDGYRELVTEALPL 160
Query: 273 DITFDGNPIAQESW 286
+ DG P+ E W
Sbjct: 161 LLDLDGQPVV-ERW 173
Score = 54.3 bits (129), Expect = 4e-07
Identities = 41/133 (30%), Positives = 65/133 (48%), Gaps = 3/133 (2%)
Query: 70 LVSSSLSSFPILQRSSEEKILYSDRLS---LERQKLTVCPIINGEDHLRLLNFQHNFITR 126
L++ +FP SE+ D L L+R+ +T + G +L L Q N I +
Sbjct: 21 LITKRNLTFPEDGELSEKMFHTLDELQTVRLDREGITTIRNLEGLQNLHSLYLQGNKIQQ 80
Query: 127 IQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLH 186
I+N++ + L L L NQI ++ L L CL+ L L +N I+ + E +SL +L+L
Sbjct: 81 IENLACIPSLRFLSLAGNQIRQVENLLDLPCLQFLDLSENLIETLKLDEFPQSLLILNLS 140
Query: 187 GNQITKIENINHL 199
GN T + L
Sbjct: 141 GNSCTNQDGYREL 153
Score = 48.9 bits (115), Expect = 2e-05
Identities = 37/103 (35%), Positives = 53/103 (51%)
Query: 133 LQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITK 192
L +L ++ L I I L L+ L L L N+I++I NL + SL L L GNQI +
Sbjct: 43 LDELQTVRLDREGITTIRNLEGLQNLHSLYLQGNKIQQIENLACIPSLRFLSLAGNQIRQ 102
Query: 193 IENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQIT 235
+EN+ L L+ L+L+ N + + SL LNL N T
Sbjct: 103 VENLLDLPCLQFLDLSENLIETLKLDEFPQSLLILNLSGNSCT 145
>gi|71040111 fibromodulin precursor [Homo sapiens]
Length = 376
Score = 60.1 bits (144), Expect = 7e-09
Identities = 63/212 (29%), Positives = 107/212 (50%), Gaps = 19/212 (8%)
Query: 88 KILYSDRLSLERQKLTVCPIINGEDHLRLLNFQHNFITRIQN--ISNLQKLISLDLYDNQ 145
K+ + +RL L+ LT P LR L+ HN I+R+ N + L+ L +L L N+
Sbjct: 153 KLRHLERLYLDHNNLTRMPGPLPRS-LRELHLDHNQISRVPNNALEGLENLTALYLQHNE 211
Query: 146 IEEI-SGLSTLRCLRVLLLGKNRIKKISNLENLKS-LDVLDLHGNQITKIEN--INHLCE 201
I+E+ S + LR L +L L N ++K+ + L S L+ L + N + + + +
Sbjct: 212 IQEVGSSMRGLRSLILLDLSYNHLRKVP--DGLPSALEQLYMEHNNVYTVPDSYFRGAPK 269
Query: 202 LRVLNLARNFLSH---VDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLFLSFN---- 254
L + L+ N L++ N SL EL+L +NQ+ + V+ L++L+L N
Sbjct: 270 LLYVRLSHNSLTNNGLASNTFNSSSLLELDLSYNQLQKIPPVNTN--LENLYLQGNRINE 327
Query: 255 -NISSFDSVSCLADSSSLSDITFDGNPIAQES 285
+ISSF +V + + S L + DGN I + +
Sbjct: 328 FSISSFCTVVDVVNFSKLQVLRLDGNEIKRSA 359
Score = 42.0 bits (97), Expect = 0.002
Identities = 46/148 (31%), Positives = 70/148 (47%), Gaps = 24/148 (16%)
Query: 114 LRLLNFQHNFITRIQN--ISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKI 171
++ + FQ+N IT IQ N L+ + L+ NQI +G+ K+
Sbjct: 107 MKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDK------------VGRKVFSKL 154
Query: 172 SNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDN--LNGLDSLTELNL 229
+LE L L N +T++ LR L+L N +S V N L GL++LT L L
Sbjct: 155 RHLERLY------LDHNNLTRMPGPLPR-SLRELHLDHNQISRVPNNALEGLENLTALYL 207
Query: 230 RHNQITFV-RDVDNLPCLQHLFLSFNNI 256
+HN+I V + L L L LS+N++
Sbjct: 208 QHNEIQEVGSSMRGLRSLILLDLSYNHL 235
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 59.7 bits (143), Expect = 9e-09
Identities = 61/179 (34%), Positives = 92/179 (51%), Gaps = 13/179 (7%)
Query: 134 QKLISLDLYDNQIEEISGLS-TLRCLRVLLLGKNRIKKISNL--ENLKSLDVLDLHGNQI 190
+ L++L L N+I ++ + L L L L +NRI+ I L + L SL+VL L N I
Sbjct: 188 RSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNI 247
Query: 191 TKIEN--INHLCELRVLNLARNFLSHVDN--LNGLDSLTELNLRHNQITFVRDVDNLPC- 245
+K+ + L ++ VL+L N L V++ L GL +L +L+L +N I + C
Sbjct: 248 SKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQ 307
Query: 246 -LQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDM 303
L L LSFNN++ D S LA+ SSLS + N I S + + LR LD+
Sbjct: 308 KLHELVLSFNNLTRLDEES-LAELSSLSVLRLSHNSI---SHIAEGAFKGLRSLRVLDL 362
Score = 49.7 bits (117), Expect = 9e-06
Identities = 54/164 (32%), Positives = 77/164 (46%), Gaps = 15/164 (9%)
Query: 110 GEDHLRLLNFQHNFITRIQNIS--NLQKLISLDLYDNQIEEI--SGLSTLRCLRVLLLGK 165
G + +L+ ++N + + + S L L L L +N I I G S + L L+L
Sbjct: 257 GLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSF 316
Query: 166 NRIKKIS--NLENLKSLDVLDLHGNQITKIEN--INHLCELRVLNLARNFLSHVDN---- 217
N + ++ +L L SL VL L N I+ I L LRVL+L N +S
Sbjct: 317 NNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSG 376
Query: 218 -LNGLDSLTELNLRHNQITFV--RDVDNLPCLQHLFLSFNNISS 258
+GLDSL++L L N+I V R L L+HL L N I S
Sbjct: 377 AFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRS 420
>gi|5901898 leucine rich repeat containing 23 isoform b [Homo
sapiens]
Length = 312
Score = 58.5 bits (140), Expect = 2e-08
Identities = 55/180 (30%), Positives = 84/180 (46%), Gaps = 29/180 (16%)
Query: 94 RLSLERQKLTVCPIINGEDHLRLLNFQHNFITRIQNISNLQKLISL-------------- 139
+L ++ + LT ++ HLR ++ N +T + ++ L L+ L
Sbjct: 73 KLEVKERDLTDIYLLRSYIHLRYVDISENHLTDLSPLNYLTHLLWLKADGNRLRSAQMNE 132
Query: 140 -------DLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNL--ENLKSLDVLDLHGNQI 190
NQI + G+S R L L L N I ++ L E L SL ++L GNQ+
Sbjct: 133 LPYLQIASFAYNQITDTEGISHPR-LETLNLKGNSIHMVTGLDPEKLISLHTVELRGNQL 191
Query: 191 TKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQIT----FVRDVDNLPCL 246
IN L +L+ L LA+N L V+ L L +LT L+LR NQI F R++ +L L
Sbjct: 192 ESTLGIN-LPKLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDNQIDTLSGFSREMKSLQYL 250
Score = 57.4 bits (137), Expect = 4e-08
Identities = 64/229 (27%), Positives = 106/229 (46%), Gaps = 21/229 (9%)
Query: 104 VCPIINGEDHLRL-LNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLL 162
+C NG H + L + +T I + + L +D+ +N + ++S L+ L L L
Sbjct: 60 LCKTGNGLAHAYVKLEVKERDLTDIYLLRSYIHLRYVDISENHLTDLSPLNYLTHLLWLK 119
Query: 163 LGKNRIKKISNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNG-- 220
NR++ + + L L + NQIT E I+H L LNL N + V L+
Sbjct: 120 ADGNRLRS-AQMNELPYLQIASFAYNQITDTEGISHP-RLETLNLKGNSIHMVTGLDPEK 177
Query: 221 LDSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNP 280
L SL + LR NQ+ + NLP L++L+L+ N + V L D S+L+ + N
Sbjct: 178 LISLHTVELRGNQLESTLGI-NLPKLKNLYLAQNMLK---KVEGLEDLSNLTTLHLRDNQ 233
Query: 281 IAQESWYKHTVLQNMMQLRQLDMKRITEEERRMASVLAKKEEEKKRESH 329
I S + + M L+ L+++R + LA + ++ R SH
Sbjct: 234 IDTLSGFS----REMKSLQYLNLRR--------SKTLAFRPDQTPRGSH 270
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,115,133
Number of Sequences: 37866
Number of extensions: 979693
Number of successful extensions: 6460
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 246
Number of HSP's that attempted gapping in prelim test: 5538
Number of HSP's gapped (non-prelim): 852
length of query: 686
length of database: 18,247,518
effective HSP length: 109
effective length of query: 577
effective length of database: 14,120,124
effective search space: 8147311548
effective search space used: 8147311548
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.