Guide to the Human Genome
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Search of human proteins with 55742695

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|55742695 sterile alpha motif domain containing 4B [Homo
sapiens]
         (694 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|55742695 sterile alpha motif domain containing 4B [Homo sapiens]  1403   0.0  
gi|239582747 sterile alpha motif domain containing 4 isoform 1 [...   825   0.0  
gi|239582749 sterile alpha motif domain containing 4 isoform 2 [...   617   e-177
gi|239582751 sterile alpha motif domain containing 4 isoform 3 [...   315   9e-86
gi|149158690 HLA-B associated transcript-2 [Homo sapiens]              49   2e-05
gi|21735419 zinc finger, CCHC domain containing 14 [Homo sapiens]      48   3e-05
gi|33356148 formin-like 1 [Homo sapiens]                               45   2e-04
gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [...    45   3e-04
gi|153792074 proline rich 12 [Homo sapiens]                            45   3e-04
gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens]             44   4e-04
gi|194248095 epsin 1 isoform b [Homo sapiens]                          44   5e-04
gi|52485606 formin-like 2 [Homo sapiens]                               44   7e-04
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]       43   0.001
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2...    42   0.001
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1...    42   0.001
gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]                     42   0.003
gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]                     42   0.003
gi|41350201 epsin 1 isoform c [Homo sapiens]                           42   0.003
gi|194272148 epsin 1 isoform a [Homo sapiens]                          42   0.003
gi|112421108 capicua homolog [Homo sapiens]                            41   0.003
gi|24497513 homeobox A3 isoform a [Homo sapiens]                       41   0.004
gi|13562112 homeobox A3 isoform a [Homo sapiens]                       41   0.004
gi|56682953 epidermal growth factor receptor pathway substrate 8...    41   0.004
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]                     40   0.006
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]                     40   0.006
gi|148536848 carboxyl ester lipase precursor [Homo sapiens]            40   0.006
gi|29826321 adducin 1 (alpha) isoform b [Homo sapiens]                 40   0.006
gi|29826319 adducin 1 (alpha) isoform a [Homo sapiens]                 40   0.006
gi|4507691 transformation/transcription domain-associated protei...    40   0.006
gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sap...    40   0.006

>gi|55742695 sterile alpha motif domain containing 4B [Homo sapiens]
          Length = 694

 Score = 1403 bits (3632), Expect = 0.0
 Identities = 694/694 (100%), Positives = 694/694 (100%)

Query: 1   MMFRDQVGILAGWFKGWNECEQTVALLSLLKRVTRTQARFLQLCLEHSLADCNDIHLLES 60
           MMFRDQVGILAGWFKGWNECEQTVALLSLLKRVTRTQARFLQLCLEHSLADCNDIHLLES
Sbjct: 1   MMFRDQVGILAGWFKGWNECEQTVALLSLLKRVTRTQARFLQLCLEHSLADCNDIHLLES 60

Query: 61  EANSAAIVSQWQQESKEKVVSLLLSHLPLLQPGNTEAKSEYMRLLQKVLAYSIESNAFIE 120
           EANSAAIVSQWQQESKEKVVSLLLSHLPLLQPGNTEAKSEYMRLLQKVLAYSIESNAFIE
Sbjct: 61  EANSAAIVSQWQQESKEKVVSLLLSHLPLLQPGNTEAKSEYMRLLQKVLAYSIESNAFIE 120

Query: 121 ESRQLLSYALIHPATTLEDRNALALWLSHLEERLASGFRSRPEPSYHSRQGSDEWGGPAE 180
           ESRQLLSYALIHPATTLEDRNALALWLSHLEERLASGFRSRPEPSYHSRQGSDEWGGPAE
Sbjct: 121 ESRQLLSYALIHPATTLEDRNALALWLSHLEERLASGFRSRPEPSYHSRQGSDEWGGPAE 180

Query: 181 LGPGEAGPGWQDKPPRENGHVPFHPSSSVPPAINSIGSNANTGLPCQIHPSPLKRSMSLI 240
           LGPGEAGPGWQDKPPRENGHVPFHPSSSVPPAINSIGSNANTGLPCQIHPSPLKRSMSLI
Sbjct: 181 LGPGEAGPGWQDKPPRENGHVPFHPSSSVPPAINSIGSNANTGLPCQIHPSPLKRSMSLI 240

Query: 241 PTSPQVPGEWPSPEELGARAAFTTPDHAPLSPQSSVASSGSEQTEEQGSSRNTFQEDGSG 300
           PTSPQVPGEWPSPEELGARAAFTTPDHAPLSPQSSVASSGSEQTEEQGSSRNTFQEDGSG
Sbjct: 241 PTSPQVPGEWPSPEELGARAAFTTPDHAPLSPQSSVASSGSEQTEEQGSSRNTFQEDGSG 300

Query: 301 MKDVPSWLKSLRLHKYAALFSQMSYEEMMTLTEQHLESQNVTKGARHKIALSIQKLRERQ 360
           MKDVPSWLKSLRLHKYAALFSQMSYEEMMTLTEQHLESQNVTKGARHKIALSIQKLRERQ
Sbjct: 301 MKDVPSWLKSLRLHKYAALFSQMSYEEMMTLTEQHLESQNVTKGARHKIALSIQKLRERQ 360

Query: 361 SVLKSLEKDVLEGGNLRNALQELQQIIITPIKAYSVLQATVAAATTTPTAKDGAPGEPPL 420
           SVLKSLEKDVLEGGNLRNALQELQQIIITPIKAYSVLQATVAAATTTPTAKDGAPGEPPL
Sbjct: 361 SVLKSLEKDVLEGGNLRNALQELQQIIITPIKAYSVLQATVAAATTTPTAKDGAPGEPPL 420

Query: 421 PGAEPPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPAPAPVADGDIPSQFTRVMG 480
           PGAEPPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPAPAPVADGDIPSQFTRVMG
Sbjct: 421 PGAEPPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPAPAPVADGDIPSQFTRVMG 480

Query: 481 KVCTQLLVSRPDEENITSYLQLIEKCLTHEAFTETQKKRLLSWKQQVLKLLRTFPRKAAL 540
           KVCTQLLVSRPDEENITSYLQLIEKCLTHEAFTETQKKRLLSWKQQVLKLLRTFPRKAAL
Sbjct: 481 KVCTQLLVSRPDEENITSYLQLIEKCLTHEAFTETQKKRLLSWKQQVLKLLRTFPRKAAL 540

Query: 541 EMQNYRQQKGWAFGSNSLPIAGSVGMGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGVS 600
           EMQNYRQQKGWAFGSNSLPIAGSVGMGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGVS
Sbjct: 541 EMQNYRQQKGWAFGSNSLPIAGSVGMGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGVS 600

Query: 601 PRHALTSPSLGGQGRQNLWFANPGGSNSMPSQSRSSVQRTHSLPVHSSPQAILMFPPDCP 660
           PRHALTSPSLGGQGRQNLWFANPGGSNSMPSQSRSSVQRTHSLPVHSSPQAILMFPPDCP
Sbjct: 601 PRHALTSPSLGGQGRQNLWFANPGGSNSMPSQSRSSVQRTHSLPVHSSPQAILMFPPDCP 660

Query: 661 VPGPDLEINPTLESLCLSMTEHALGDGTDKTSTI 694
           VPGPDLEINPTLESLCLSMTEHALGDGTDKTSTI
Sbjct: 661 VPGPDLEINPTLESLCLSMTEHALGDGTDKTSTI 694


>gi|239582747 sterile alpha motif domain containing 4 isoform 1
           [Homo sapiens]
          Length = 717

 Score =  825 bits (2132), Expect = 0.0
 Identities = 448/730 (61%), Positives = 535/730 (73%), Gaps = 50/730 (6%)

Query: 2   MFRDQVGILAGWFKGWNECEQTVALLSLLKRVTRTQARFLQLCLEHSLADCNDIHLLESE 61
           MFRDQVG+LAGWFKGWNECEQTVALLSLLKRV++TQARFLQLCLEHSLADC ++H+LE E
Sbjct: 1   MFRDQVGVLAGWFKGWNECEQTVALLSLLKRVSQTQARFLQLCLEHSLADCAELHVLERE 60

Query: 62  ANSAAIVSQWQQESKEKVVSLLLSHLPLLQPGNTEAKSEYMRLLQKVLAYSIESNAFIEE 121
           ANS  I++QWQQESK+KV+SLLL+HLPLL+PGN +AK EYM+LL K+LA+SIE N  IEE
Sbjct: 61  ANSPGIINQWQQESKDKVISLLLTHLPLLKPGNLDAKVEYMKLLPKILAHSIEHNQHIEE 120

Query: 122 SRQLLSYALIHPATTLEDRNALALWLSHLEERLASGF----RSRPEP-------SYHSRQ 170
           SRQLLSYALIHPAT+LEDR+ALA+WL+HLE+R ++ F    R R +         YH RQ
Sbjct: 121 SRQLLSYALIHPATSLEDRSALAMWLNHLEDRTSTSFGGQNRGRSDSVDYGQTHYYHQRQ 180

Query: 171 GSDE----WGGPAELGPGEAGPGWQDKPPR-ENGHVPFHPSSSVPPAINSIGSNANTGLP 225
            SD+    W    + G       WQDK    ENGHVP + SSSVP  IN+IG++ +T L 
Sbjct: 181 NSDDKLNGWQNSRDSGICINASNWQDKSMGCENGHVPLYSSSSVPTTINTIGTSTSTILS 240

Query: 226 CQIHPSPLKRSMSLIPTSPQVPGE-----WPSPEELGARAAFTTP-DHAPLSPQSSVASS 279
            Q H SPLKRS+SL P    VP +     W S E+L AR     P DHAPLSPQSSVASS
Sbjct: 241 GQAHHSPLKRSVSLTPPM-NVPNQPLGHGWMSHEDLRARGPQCLPSDHAPLSPQSSVASS 299

Query: 280 ---GSEQTEEQGSSRNTFQEDGSGMKDVPSWLKSLRLHKYAALFSQMSYEEMMTLTEQHL 336
              GSE  E+Q ++RNTFQE+GSGMKDVP+WLKSLRLHKYAALFSQM+YEEMM LTE  L
Sbjct: 300 GSGGSEHLEDQTTARNTFQEEGSGMKDVPAWLKSLRLHKYAALFSQMTYEEMMALTECQL 359

Query: 337 ESQNVTKGARHKIALSIQKLRERQSVLKSLEKDVLEGGNLRNALQELQQIIITPIKAYSV 396
           E+QNVTKGARHKI +SIQKL+ERQ++LKSLE+D++EGG+LR  LQEL Q+I+TPIKAYS 
Sbjct: 360 EAQNVTKGARHKIVISIQKLKERQNLLKSLERDIIEGGSLRIPLQELHQMILTPIKAYS- 418

Query: 397 LQATVAAATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYPPPPAPAPT 456
                 + +TTP A+   P  P  P    P       +  + KD  A       P+   +
Sbjct: 419 ------SPSTTPEARRREPQAPRQPSLMGP-----ESQSPDCKDGAAATGATATPSAGAS 467

Query: 457 DGSEP----------APAPVADGDIPSQFTRVMGKVCTQLLVSRPDEENITSYLQLIEKC 506
            G +P          A AP+ +GD+P QFTRVMGKVCTQLLVSRPDEENI+SYLQLI+KC
Sbjct: 468 GGLQPHQLSSCDGELAVAPLPEGDLPGQFTRVMGKVCTQLLVSRPDEENISSYLQLIDKC 527

Query: 507 LTHEAFTETQKKRLLSWKQQVLKLLRTFPRKAALEMQNYRQQKGWAFG-SNSLPIAGSVG 565
           L HEAFTETQKKRLLSWKQQV KL R+FPRK  L++  YRQQ+   FG SNSLP AGSVG
Sbjct: 528 LIHEAFTETQKKRLLSWKQQVQKLFRSFPRKTLLDISGYRQQRNRGFGQSNSLPTAGSVG 587

Query: 566 MGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGVSPRHALTSPSLGGQGRQNLWFANPGG 625
            G+ RR  RQ+ +P R +P  R+GLL  SG    + R+   +P++  QGRQNLWFANPGG
Sbjct: 588 GGMGRRNPRQYQIPSRNVPSARLGLLGTSGFVSSNQRNTTATPTIMKQGRQNLWFANPGG 647

Query: 626 SNSMPSQSRSSVQRTHSLPVHSSPQAILMF-PPDCPVPGPDLEINPTLESLCLSMTEHAL 684
           SNSMPS++ SSVQRT SLPVH+SPQ +LMF  P+  +P  + +IN  LESLCLSMTEHAL
Sbjct: 648 SNSMPSRTHSSVQRTRSLPVHTSPQNMLMFQQPEFQLPVTEPDINNRLESLCLSMTEHAL 707

Query: 685 GDGTDKTSTI 694
           GDG D+TSTI
Sbjct: 708 GDGVDRTSTI 717


>gi|239582749 sterile alpha motif domain containing 4 isoform 2
           [Homo sapiens]
          Length = 629

 Score =  617 bits (1592), Expect = e-177
 Identities = 359/709 (50%), Positives = 443/709 (62%), Gaps = 96/709 (13%)

Query: 2   MFRDQVGILAGWFKGWNECEQTVALLSLLKRVTRTQARFLQLCLEHSLADCNDIHLLESE 61
           MFRDQVG+LAGWFKGWNECEQTVALLSLLKRV++TQARFLQLCLEHSLADC ++H+LE E
Sbjct: 1   MFRDQVGVLAGWFKGWNECEQTVALLSLLKRVSQTQARFLQLCLEHSLADCAELHVLERE 60

Query: 62  ANSAAIVSQWQQESKEKVVSLLLSHLPLLQPGNTEAKSEYMRLLQKVLAYSIESNAFIEE 121
           ANS  I++QWQQESK+KV+SLLL+HLPLL+PGN +AK EYM+LL K+L            
Sbjct: 61  ANSPGIINQWQQESKDKVISLLLTHLPLLKPGNLDAKVEYMKLLPKIL------------ 108

Query: 122 SRQLLSYALIHPATTLEDRNALALWLSHLEERLASGFRSRPEPSYHSRQGSDEWGGPAE- 180
                ++++ H     E R  L+  L H            P  S   R     W    E 
Sbjct: 109 -----AHSIEHNQHIEESRQLLSYALIH------------PATSLEDRSALAMWLNHLED 151

Query: 181 ---LGPGEAGPGWQDKPPRENGHVPFHPSSSVPPAINSIGSNANTGLPCQIHPSPLKRSM 237
                 G    G  D       H  +H   +    +N   ++ ++G+             
Sbjct: 152 RTSTSFGGQNRGRSDSVDYGQTHY-YHQRQNSDDKLNGWQNSRDSGICINA--------- 201

Query: 238 SLIPTSPQVPGEWPSPEELGARAAFTTPDHAPLSPQSSVASSGSEQTEEQGSSRNTFQED 297
                       W   + +G         H PL   SSV ++        G+S +T    
Sbjct: 202 ----------SNWQD-KSMGCENG-----HVPLYSSSSVPTT----INTIGTSTST---- 237

Query: 298 GSGMKDVPSWLKSLRLHKYAALFSQMSYEEMMTLTEQHLESQNVTKGARHKIALSIQKLR 357
                +VP+WLKSLRLHKYAALFSQM+YEEMM LTE  LE+QNVTKGARHKI +SIQKL+
Sbjct: 238 -----NVPAWLKSLRLHKYAALFSQMTYEEMMALTECQLEAQNVTKGARHKIVISIQKLK 292

Query: 358 ERQSVLKSLEKDVLEGGNLRNALQELQQIIITPIKAYSVLQATVAAATTTPTAKDGAPGE 417
           ERQ++LKSLE+D++EGG+LR  LQEL Q+I+TPIKAYS       + +TTP A+   P  
Sbjct: 293 ERQNLLKSLERDIIEGGSLRIPLQELHQMILTPIKAYS-------SPSTTPEARRREPQA 345

Query: 418 PPLPGAEPPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEP----------APAPVA 467
           P  P    P       +  + KD  A       P+   + G +P          A AP+ 
Sbjct: 346 PRQPSLMGP-----ESQSPDCKDGAAATGATATPSAGASGGLQPHQLSSCDGELAVAPLP 400

Query: 468 DGDIPSQFTRVMGKVCTQLLVSRPDEENITSYLQLIEKCLTHEAFTETQKKRLLSWKQQV 527
           +GD+P QFTRVMGKVCTQLLVSRPDEENI+SYLQLI+KCL HEAFTETQKKRLLSWKQQV
Sbjct: 401 EGDLPGQFTRVMGKVCTQLLVSRPDEENISSYLQLIDKCLIHEAFTETQKKRLLSWKQQV 460

Query: 528 LKLLRTFPRKAALEMQNYRQQKGWAFG-SNSLPIAGSVGMGVARRTQRQFPMPPRALPPG 586
            KL R+FPRK  L++  YRQQ+   FG SNSLP AGSVG G+ RR  RQ+ +P R +P  
Sbjct: 461 QKLFRSFPRKTLLDISGYRQQRNRGFGQSNSLPTAGSVGGGMGRRNPRQYQIPSRNVPSA 520

Query: 587 RMGLLSPSGIGGVSPRHALTSPSLGGQGRQNLWFANPGGSNSMPSQSRSSVQRTHSLPVH 646
           R+GLL  SG    + R+   +P++  QGRQNLWFANPGGSNSMPS++ SSVQRT SLPVH
Sbjct: 521 RLGLLGTSGFVSSNQRNTTATPTIMKQGRQNLWFANPGGSNSMPSRTHSSVQRTRSLPVH 580

Query: 647 SSPQAILMF-PPDCPVPGPDLEINPTLESLCLSMTEHALGDGTDKTSTI 694
           +SPQ +LMF  P+  +P  + +IN  LESLCLSMTEHALGDG D+TSTI
Sbjct: 581 TSPQNMLMFQQPEFQLPVTEPDINNRLESLCLSMTEHALGDGVDRTSTI 629


>gi|239582751 sterile alpha motif domain containing 4 isoform 3
           [Homo sapiens]
          Length = 345

 Score =  315 bits (807), Expect = 9e-86
 Identities = 181/357 (50%), Positives = 218/357 (61%), Gaps = 60/357 (16%)

Query: 386 IIITPIKAYSVLQATVAAATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPPAVE 445
           +I+TPIKAYS       + +TTP A+   P  P  P    P       +  + KD  A  
Sbjct: 1   MILTPIKAYS-------SPSTTPEARRREPQAPRQPSLMGP-----ESQSPDCKDGAAAT 48

Query: 446 NYPPPPAPAPTDGSEP----------APAPVADGDIPSQFTRVMGKVCTQLLVSRPDEEN 495
                P+   + G +P          A AP+ +GD+P QFTRVMGKVCTQLLVSRPDEEN
Sbjct: 49  GATATPSAGASGGLQPHQLSSCDGELAVAPLPEGDLPGQFTRVMGKVCTQLLVSRPDEEN 108

Query: 496 ITSYLQLIEKCLTHEAFTETQKKRLLSWKQQVLKLLRTFPRKAALEMQNYRQQKGWAFG- 554
           I+SYLQLI+KCL HEAFTETQKKRLLSWKQQV KL R+FPRK  L++  YRQQ+   FG 
Sbjct: 109 ISSYLQLIDKCLIHEAFTETQKKRLLSWKQQVQKLFRSFPRKTLLDISGYRQQRNRGFGQ 168

Query: 555 SNSLPIAGSVGMGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGVSPRHALTSPSLGGQG 614
           SNSLP AGSVG G+ RR  RQ+ +P R +P  R+GLL  SG    + R+   +P++  QG
Sbjct: 169 SNSLPTAGSVGGGMGRRNPRQYQIPSRNVPSARLGLLGTSGFVSSNQRNTTATPTIMKQG 228

Query: 615 RQNLWFANPGGSNSMPSQSRSSVQRTHSLPVHSSPQAILMF------------------- 655
           RQNLWFANPGGSNSMPS++ SSVQRT SLPVH+SPQ +LMF                   
Sbjct: 229 RQNLWFANPGGSNSMPSRTHSSVQRTRSLPVHTSPQNMLMFQQPGSQVHSGLCLTDLRGW 288

Query: 656 -----PPDCP-------------VPGPDLEINPTLESLCLSMTEHALGDGTDKTSTI 694
                 P  P             +P  + +IN  LESLCLSMTEHALGDG D+TSTI
Sbjct: 289 LSLSGAPSMPALTVPKSSQGEFQLPVTEPDINNRLESLCLSMTEHALGDGVDRTSTI 345


>gi|149158690 HLA-B associated transcript-2 [Homo sapiens]
          Length = 2157

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 72/302 (23%), Positives = 114/302 (37%), Gaps = 28/302 (9%)

Query: 343 KGARHKIALSIQKLRERQSVLKSLEKDVLEGGNLRNALQELQQIIITPIKAYSVLQATVA 402
           K +  +I+L++++ R R+   +   ++          L+ L +    P K      A   
Sbjct: 454 KQSSSEISLAVERARRRREEEERRMQEERRAA-CAEKLKRLDEKFGAPDKRLKAEPAAPP 512

Query: 403 AATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPA 462
           AA +TP      P E P P A PP + P  +  TE ++P       PP    PT G   A
Sbjct: 513 AAPSTPAPPPAVPKELPAPPAPPPASAPTPE--TEPEEPAQA----PPAQSTPTPGVAAA 566

Query: 463 PAPVADGDIPS-------QFTRVMGKVCTQLLVSRPDE--ENITSYLQLIEKCLTHEAFT 513
           P  V+ G   S       + + V  ++ ++     P+E     T  +  +E        T
Sbjct: 567 PTLVSGGGSTSSTSSGSFEASPVEPQLPSKEGPEPPEEVPPPTTPPVPKVEPKGDGIGPT 626

Query: 514 ETQKKRLLSWKQQVLKLLRTFPRKAALEMQNYRQQKGW----AFGSNSLPIAGS----VG 565
                + L + +    L   F R+   ++   +QQ  W       +   P+  S    V 
Sbjct: 627 RQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQQQHQWQQHQQGSAPPTPVPPSPPQPVT 686

Query: 566 MGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGVSPRHALTSPSLGG---QGRQNLWFAN 622
           +G     Q   P PP+AL PG +G   P       PR  +  P +     QGR  L F  
Sbjct: 687 LGAVPAPQAP-PPPPKALYPGALGRPPPMPPMNFDPRWMMIPPYVDPRLLQGRPPLDFYP 745

Query: 623 PG 624
           PG
Sbjct: 746 PG 747



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 35/141 (24%), Positives = 50/141 (35%), Gaps = 34/141 (24%)

Query: 157  GFRSRPEPSYHSRQGSDEWGGPAELGPGEAGPGWQDKPPRENGHVPFHPSSS------VP 210
            G RSR   SY   +G D  GG         G G  + PP   G       S       +P
Sbjct: 1048 GARSREFRSYREFRGDDGRGG---------GTGGPNHPPAPRGRTASETRSEGSEYEEIP 1098

Query: 211  PAINSIGSNANTGLPCQIH-----------PSPLKRSMSLIPTSPQVPGEWPSPEELGAR 259
                  GS   +    + H           P+P + +++ +P +P  PG  PSP    A 
Sbjct: 1099 KRRRQRGSETGS----ETHESDLAPSDKEAPTPKEGTLTQVPLAPPPPGAPPSP----AP 1150

Query: 260  AAFTTPDHAPLSPQSSVASSG 280
            A FT       +P+   +  G
Sbjct: 1151 ARFTARGGRVFTPRGVPSRRG 1171



 Score = 30.0 bits (66), Expect = 7.5
 Identities = 20/59 (33%), Positives = 26/59 (44%), Gaps = 10/59 (16%)

Query: 412  DGAPGEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTD-------GSEPAP 463
            +  P E P PG+EPP   P      + K+ P     P PP P  T+       G+EP P
Sbjct: 1694 NAVPCEGP-PGSEPPRRPPPAPHDGDRKELP--REQPLPPGPIGTERSQRTDRGTEPGP 1749


>gi|21735419 zinc finger, CCHC domain containing 14 [Homo sapiens]
          Length = 949

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 45/151 (29%), Positives = 71/151 (47%), Gaps = 25/151 (16%)

Query: 230 PSPLKRSMSLIPTSPQVPGEWPSPEELGARAAFTTPDH---------APLSPQSSVASSG 280
           PSP   S+S + T   V G  P     G  ++ +   H         APL   S   S+G
Sbjct: 211 PSPGNPSLSKVGTVMGVSGR-PVCGVAGIPSSQSGAQHHGQHPAGSAAPLPHCSHAGSAG 269

Query: 281 SEQTEE----------QGSSRNTFQ-EDGSGMKDVPSWLKSLRLHKYAALFSQMSYEEMM 329
           S                 SS  T Q ++ +G+ D   WL+ LRLHKY  +F Q+S E+ +
Sbjct: 270 SALAYRTQMDTSPAILMPSSLQTPQTQEQNGILD---WLRKLRLHKYYPVFKQLSMEKFL 326

Query: 330 TLTEQHLES-QNVTKGARHKIALSIQKLRER 359
           +LTE+ L   +++T GA+ K+   ++  +E+
Sbjct: 327 SLTEEDLNKFESLTMGAKKKLKTQLELEKEK 357


>gi|33356148 formin-like 1 [Homo sapiens]
          Length = 1100

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 47/175 (26%), Positives = 68/175 (38%), Gaps = 31/175 (17%)

Query: 315 KYAALFSQMSY--EEMMTLTEQHLESQNVTKGAR---------------HKIALSIQKLR 357
           K A L  Q+S   +E+ TL E+  ES  +    R                 + L +++L 
Sbjct: 425 KIAELEKQLSQARKELETLRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKVEELE 484

Query: 358 ERQSVLKSLEKDVLEGGNLRNALQELQQIIITPIKAYSVLQATVAAATTTPTAKDGAPGE 417
           E+  +       +L G     +++ L   + TP    S   A      T   + D AP  
Sbjct: 485 EKGLIR------ILRGPGDAVSIEILPVAVATP----SGGDAPTPGVPTGSPSPDLAPAA 534

Query: 418 PPLPGAEPPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPAPAPVADGDIP 472
            P PGA PP   P     +  + PP+     PP AP      EP PAP   GD+P
Sbjct: 535 EPAPGAAPPPPPPLPGLPSPQEAPPSA----PPQAPPLPGSPEPPPAPPLPGDLP 585



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 34/130 (26%), Positives = 49/130 (37%), Gaps = 11/130 (8%)

Query: 403 AATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYPPPPAPAP----TDG 458
           AA   P    G P     P + PP A P          PP   + PPPP P P    TDG
Sbjct: 540 AAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDG 599

Query: 459 ---SEPAPAPVADGDIPSQFTRVMGKVCTQLLVSRPDEEN----ITSYLQLIEKCLTHEA 511
                P P P   G  P    R   ++   +   +P +      + +++ L    +T   
Sbjct: 600 PVPPPPPPPPPPPGGPPDALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTV 659

Query: 512 FTETQKKRLL 521
           FTE   +++L
Sbjct: 660 FTELNDEKVL 669


>gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [Homo
            sapiens]
          Length = 1636

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 72/299 (24%), Positives = 116/299 (38%), Gaps = 51/299 (17%)

Query: 195  PRENGHVPFHPSSSVP-PAINSIGSNANTGLPCQIHPSPLKRSMSLI--PTSPQVPGEWP 251
            P E G    H + S+   ++ S  ++    L  Q     LKRS+  +  PT P++ G   
Sbjct: 1304 PTERGQPMVHGALSLALSSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPEL-GLPD 1362

Query: 252  SP-------EELGARAAFTTPDHAPLSPQSSVASSGSEQTEEQGSSRNTFQE--DGSGMK 302
            SP       +E+ A      P H P+       SSG  +T          QE   G+G+ 
Sbjct: 1363 SPSNLLRFIQEVHAHYLHQRPLHTPIIVH---CSSGVGRTGAFALLYAAVQEVEAGNGIP 1419

Query: 303  DVPSWLKSLRLHKYAALFSQMS----YEEMMTLTEQHLESQNVTKGARHKIALSIQKLRE 358
            ++P  ++ +R  +   L  ++     YE ++   EQ L+   V    +   + SI +   
Sbjct: 1420 ELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEQVLQRHGVPPPCKPLASASISQ--- 1476

Query: 359  RQSVLKSLEKDVLEGGNLRNALQELQQIIITPIKAYSVLQATVAAATTTPTAKDGAPG-- 416
             ++ L    +D++ GG++             PI   S +QAT+A  +  P      PG  
Sbjct: 1477 -KNHLPQDSQDLVLGGDV-------------PI---SSIQATIAKLSIRP------PGGL 1513

Query: 417  EPPLPGAEPPLAHPGTDKGTEAKDPPAVENYPPP---PAPAPTDGSEPAPAPVADGDIP 472
            E P+     P   PG    +  +  P   + PPP   P P      E  P P A    P
Sbjct: 1514 ESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGP 1572



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 27/76 (35%), Positives = 34/76 (44%), Gaps = 7/76 (9%)

Query: 417  EPPLPGAEPPLAHPGTDKGTEAKDP-PAVENYPPPPAPAPTDGSEPAPAPVADGDIPSQF 475
            +P + G  PP  H     G  A+DP PA     P P+P P    +P   P+A G  PS  
Sbjct: 1003 QPGVLGQPPPPLHTQLYPGP-AQDPLPAHSGALPFPSPGPP---QPPHPPLAYGPAPS-- 1056

Query: 476  TRVMGKVCTQLLVSRP 491
            TR MG     L +  P
Sbjct: 1057 TRPMGPQAAPLTIRGP 1072



 Score = 29.6 bits (65), Expect = 9.8
 Identities = 25/89 (28%), Positives = 31/89 (34%), Gaps = 9/89 (10%)

Query: 408  PTAKDGAPGEPPL-PGAEPPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPAPAPV 466
            P A   AP   P+ P A P      +  G     P  V +  P P P P     PA  P 
Sbjct: 1048 PLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTPSPHLVPSPAPSPGPGPVPPRPPAAEP- 1106

Query: 467  ADGDIPSQFTRVMGKVCTQLLVSRPDEEN 495
                 P    R  G     LL S P+ ++
Sbjct: 1107 -----PPCLRR--GAAAADLLSSSPESQH 1128


>gi|153792074 proline rich 12 [Homo sapiens]
          Length = 2036

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 42/135 (31%), Positives = 56/135 (41%), Gaps = 16/135 (11%)

Query: 337  ESQNVTKGARHKIALSIQKLRERQSVLKSLEKDVLEGGNLRNALQELQQIIITPIKAYSV 396
            ES+ +  G         ++L+     L S   D  E    +N  ++LQ+ I + I A   
Sbjct: 1351 ESEGLGLGCPSPCKRLDEELKRNLETLPSFSSDE-EDSVAKN--RDLQESISSAISALDD 1407

Query: 397  LQATVAAATTTPTAKDGAP-----GEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYPPP- 450
                    T+TP     AP     G PPLPG  P     GT       +PP +E  PPP 
Sbjct: 1408 PPLAGPKDTSTPDGPPLAPAAAVPGPPPLPGL-PSANSNGTP------EPPLLEEKPPPT 1460

Query: 451  PAPAPTDGSEPAPAP 465
            P PAPT   +P P P
Sbjct: 1461 PPPAPTPQPQPPPPP 1475



 Score = 37.7 bits (86), Expect = 0.036
 Identities = 25/64 (39%), Positives = 30/64 (46%), Gaps = 8/64 (12%)

Query: 407  TPTAKDGAPGEPPLPG--AEPPLAHPGTDKGTEAKDPPAVENYPPPPA-PAPTDGSEPAP 463
            TP  +   P  PP P   + PPL  P     T +  PP     PPPPA P+P     PA 
Sbjct: 1466 TPQPQPPPPPPPPQPALPSPPPLVAP-----TPSSPPPPPLPPPPPPAMPSPPPPPPPAA 1520

Query: 464  APVA 467
            AP+A
Sbjct: 1521 APLA 1524



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 21/60 (35%), Positives = 23/60 (38%), Gaps = 4/60 (6%)

Query: 408  PTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYP----PPPAPAPTDGSEPAP 463
            P+A      EPPL   +PP   P          PP     P    PPP  APT  S P P
Sbjct: 1440 PSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPPPQPALPSPPPLVAPTPSSPPPP 1499



 Score = 33.9 bits (76), Expect = 0.52
 Identities = 21/64 (32%), Positives = 26/64 (40%), Gaps = 11/64 (17%)

Query: 408  PTAKDGAPGEPPL----PGAEPPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPAP 463
            P  +   P  PPL    P + PP   P          PPA+ + PPPP PA    + P  
Sbjct: 1476 PPPQPALPSPPPLVAPTPSSPPPPPLP-------PPPPPAMPSPPPPPPPAAAPLAAPPE 1528

Query: 464  APVA 467
             P A
Sbjct: 1529 EPAA 1532



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 19/56 (33%), Positives = 24/56 (42%), Gaps = 5/56 (8%)

Query: 415  PGEPPLPGAEP-PLAHPGTDKGTEAKDPPAV----ENYPPPPAPAPTDGSEPAPAP 465
            P  PP P  +P P   P   +      PP V     + PPPP P P   + P+P P
Sbjct: 1459 PTPPPAPTPQPQPPPPPPPPQPALPSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPP 1514



 Score = 30.8 bits (68), Expect = 4.4
 Identities = 26/87 (29%), Positives = 34/87 (39%), Gaps = 30/87 (34%)

Query: 408 PTAKDGAPGEPPLPGAEPP---------LAHPGTD--------KGTEAKDPP-------- 442
           P  +DGAP  PP P   PP         L   G +        +  E+ DPP        
Sbjct: 826 PATRDGAPQPPPPPPPPPPPMPLQLEAHLRSHGLEPAAPSPRLRPEESLDPPGAMQELLG 885

Query: 443 AVENYPPPP-----APAPTDGSEPAPA 464
           A+E  PP P      P  ++G +PA A
Sbjct: 886 ALEPLPPAPGDTGVGPPNSEGKDPAGA 912


>gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens]
          Length = 502

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 22/59 (37%), Positives = 27/59 (45%), Gaps = 5/59 (8%)

Query: 415 PGEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPAPAPVADGDIPS 473
           P  PP  G   PL  P    G     PP     PPPP P P+ G+ PAP P+    +P+
Sbjct: 369 PPPPPATGRSGPLPPPPPGAGGPPMPPP-----PPPPPPPPSSGNGPAPPPLPPALVPA 422


>gi|194248095 epsin 1 isoform b [Homo sapiens]
          Length = 576

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 35/150 (23%), Positives = 61/150 (40%), Gaps = 22/150 (14%)

Query: 333 EQHLESQNVTKGARHKIALSIQKLRERQSVLKSLEKDVLEGGNLRNALQELQQIIITPIK 392
           E+H + + + +G   ++ ++I++ +               GG   ++L +L  +   P  
Sbjct: 222 EEHDKEERIRRGDDLRLQMAIEESKRET------------GGKEESSLMDLADVFTAPAP 269

Query: 393 AYSVLQ----ATVAAATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGT------EAKDPP 442
           A +       A +AAA  T        G PP+P A  P   P     +       A   P
Sbjct: 270 APTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAAPAGP 329

Query: 443 AVENYPPPPAPAPTDGSEPAPAPVADGDIP 472
           +V+ +   PAPA  +G  P P   +DG +P
Sbjct: 330 SVDPWGGTPAPAAGEGPTPDPWGSSDGGVP 359


>gi|52485606 formin-like 2 [Homo sapiens]
          Length = 1092

 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 36/146 (24%), Positives = 54/146 (36%), Gaps = 5/146 (3%)

Query: 323 MSYEEMMTLTEQHLESQNVTKGARHKIALSIQKLRERQSVLKSLEKDVLEGGNLRNALQE 382
           M   + + +  +  +  N       K+    ++  +RQS L+    ++ + G ++   + 
Sbjct: 428 MQRNKELDVVREIYKDANTQVHTLRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKG 487

Query: 383 LQQIIITPIKAYSVLQA---TVAAATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAK 439
              I I P+ A   L      VA  +  PT   GA    PLP   PPL        T   
Sbjct: 488 DGDIAILPVVASGTLSMGSEVVAGNSVGPTM--GAASSGPLPPPPPPLPPSSDTPETVQN 545

Query: 440 DPPAVENYPPPPAPAPTDGSEPAPAP 465
            P      PPPP P P     P P P
Sbjct: 546 GPVTPPMPPPPPPPPPPPPPPPPPPP 571



 Score = 34.7 bits (78), Expect = 0.31
 Identities = 19/63 (30%), Positives = 23/63 (36%), Gaps = 3/63 (4%)

Query: 404 ATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDP---PAVENYPPPPAPAPTDGSE 460
           ++ TP      P  PP+P   PP   P          P   PA E  P PP   P   + 
Sbjct: 536 SSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETVPAPPLAPPLPSAP 595

Query: 461 PAP 463
           P P
Sbjct: 596 PLP 598



 Score = 30.8 bits (68), Expect = 4.4
 Identities = 22/70 (31%), Positives = 26/70 (37%), Gaps = 1/70 (1%)

Query: 390 PIKAYSVLQATVAAATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYPP 449
           P+   S    TV     TP      P  PP P   PP   P    G  A+  PA    PP
Sbjct: 532 PLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPPPPPLP-GPAAETVPAPPLAPP 590

Query: 450 PPAPAPTDGS 459
            P+  P  G+
Sbjct: 591 LPSAPPLPGT 600


>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
          Length = 825

 Score = 42.7 bits (99), Expect = 0.001
 Identities = 79/337 (23%), Positives = 117/337 (34%), Gaps = 58/337 (17%)

Query: 179 AELGPGEAGPGWQDKPPRENGHVPFHPSSSVPPAINSIGSNANTGLPCQIHPSPLKRSMS 238
           AE+ P  A     ++PP E    P   S SV   +  I S +    P ++ P P + ++ 
Sbjct: 348 AEILPPSAEESPSEEPPAEILPPPAEKSPSVE-LLGEIRSPSAQKAPIEVQPLPAEGALE 406

Query: 239 LIPTS--------------PQVPGEWPSPE--ELGARAAFTTP-DHAPLSPQSSVASSGS 281
             P                P +P E P  E  EL    A  TP + AP   QS +     
Sbjct: 407 EAPAKVEPPTVEETLADVQPLLPEEAPREEARELQLSTAMETPAEEAPTEFQSPLPK--- 463

Query: 282 EQTEEQGSSR-NTFQEDGSGMKDVPSWLKSLRLHKYAALFSQMSYEEMMTLTEQHLESQN 340
           E T E+ S+             + P+  +S        L  + S EE     +  L  + 
Sbjct: 464 ETTAEEASAEIQLLAATEPPADETPAEARS-------PLSEETSAEEAHAEVQSPLAEET 516

Query: 341 VTKGARHKIAL-------SIQKLRERQSVLKS----------LEKDVLEGGNLRNALQEL 383
             + A  +I L       + +   E QS L            ++    +G ++  A  EL
Sbjct: 517 TAEEASAEIQLLAAIEAPADETPAEAQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLEL 576

Query: 384 QQ------IIITPIKAYSVLQATVAAATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTE 437
           Q              A  +L AT A+A   P      P E      +PP   P  +   E
Sbjct: 577 QPPSGEETTAEEASAAIQLLAATEASAEEAPAEVQPPPAEEAPAEVQPP---PAEEAPAE 633

Query: 438 AKDPPAVE---NYPPPPAPAPTDGSEPAPAPVADGDI 471
            + PPA E      PPPA       +P PA  A  ++
Sbjct: 634 VQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEV 670


>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
           [Homo sapiens]
          Length = 1481

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 75/325 (23%), Positives = 120/325 (36%), Gaps = 51/325 (15%)

Query: 160 SRPEPSYHSRQGSDEWGGPAELGPGEAGPGWQDKPPRENGHVPFHPSS---SVPPAINSI 216
           SR   S + R GS     P+  G   +   +  K       +P   S    S  PA +  
Sbjct: 306 SRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRH 365

Query: 217 GSNANTGLPCQIHPSPLKRSMSLIPTSPQVPGEWPSPEELGARAAFTTPDHAPLSPQSSV 276
            S+           S  KRS S    S   P   P    LGA  +    + A     ++ 
Sbjct: 366 SSSH----------SKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERA-----AAA 410

Query: 277 ASSGSEQTEEQGSSRNTFQEDGSGMKDVPSWLKSLRLHKYAALFSQMSYEEMMTLTEQHL 336
           A++  +  E +GS     +++ S ++   S L+S +L +   L       E++ +T  + 
Sbjct: 411 AAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNT 470

Query: 337 ESQNVTKGARHKIALSIQKLRERQSVLKSLEKDVLEGGNLRNALQELQQIIITPIKAYSV 396
           E +N +   + K+  + +K          L KD+   G   +    L++ I+TP +    
Sbjct: 471 EVKNSSDTGKVKLDENSEK---------HLVKDLKAQGTRDSKPIALKEEIVTPKE---- 517

Query: 397 LQATVAAATTTPTAKDGAPGEPPLPG-AEPPLAHPGTDKGTEAKDPPAVENYPP-PPAPA 454
                     T T++   P  PPLP  A PP   P T        PP     PP PP PA
Sbjct: 518 ----------TETSEKETP--PPLPTIASPPPPLPTTTP------PPQTPPLPPLPPIPA 559

Query: 455 PTDGSEPAPAPVADGDIPSQFTRVM 479
                   P+  A   +P+  T  +
Sbjct: 560 LPQQPPLPPSQPAFSQVPASSTSTL 584



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 39/195 (20%), Positives = 73/195 (37%), Gaps = 27/195 (13%)

Query: 304  VPSWLKSLRLHKYAALFSQMSY--EEMMTLTEQHLESQNVTKGARHKIALSIQKLRERQS 361
            +P   + L +H    +  Q+    + +  LTE   + Q+    A  +   S+++      
Sbjct: 1131 IPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEE---SLKEAPSAPV 1187

Query: 362  VLKSLEKDVLEGGNLRNALQELQQIIITPIKAYSVLQATVAAATTTPTAKDGAPGEPPLP 421
            +L S E+  LE  +    +Q +  ++++ +      Q    +     + K+  P  P   
Sbjct: 1188 ILPSAEQTTLEASSTPADMQNILAVLLSQLMK---TQEPAGSLEENNSDKNSGPQGPRRT 1244

Query: 422  GAEPPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPAPAPVADGDIPSQFTRVMGK 481
               P        +    K PP     PPP          P P P+ +GD+ S    +   
Sbjct: 1245 PTMP-------QEEAAEKRPPEPPGPPPP----------PPPPPLVEGDLSSAPQELNPA 1287

Query: 482  VCTQL--LVSRPDEE 494
            V   L  L+S+P+ E
Sbjct: 1288 VTAALLQLLSQPEAE 1302


>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
           [Homo sapiens]
          Length = 1490

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 75/325 (23%), Positives = 120/325 (36%), Gaps = 51/325 (15%)

Query: 160 SRPEPSYHSRQGSDEWGGPAELGPGEAGPGWQDKPPRENGHVPFHPSS---SVPPAINSI 216
           SR   S + R GS     P+  G   +   +  K       +P   S    S  PA +  
Sbjct: 306 SRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRH 365

Query: 217 GSNANTGLPCQIHPSPLKRSMSLIPTSPQVPGEWPSPEELGARAAFTTPDHAPLSPQSSV 276
            S+           S  KRS S    S   P   P    LGA  +    + A     ++ 
Sbjct: 366 SSSH----------SKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERA-----AAA 410

Query: 277 ASSGSEQTEEQGSSRNTFQEDGSGMKDVPSWLKSLRLHKYAALFSQMSYEEMMTLTEQHL 336
           A++  +  E +GS     +++ S ++   S L+S +L +   L       E++ +T  + 
Sbjct: 411 AAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNT 470

Query: 337 ESQNVTKGARHKIALSIQKLRERQSVLKSLEKDVLEGGNLRNALQELQQIIITPIKAYSV 396
           E +N +   + K+  + +K          L KD+   G   +    L++ I+TP +    
Sbjct: 471 EVKNSSDTGKVKLDENSEK---------HLVKDLKAQGTRDSKPIALKEEIVTPKE---- 517

Query: 397 LQATVAAATTTPTAKDGAPGEPPLPG-AEPPLAHPGTDKGTEAKDPPAVENYPP-PPAPA 454
                     T T++   P  PPLP  A PP   P T        PP     PP PP PA
Sbjct: 518 ----------TETSEKETP--PPLPTIASPPPPLPTTTP------PPQTPPLPPLPPIPA 559

Query: 455 PTDGSEPAPAPVADGDIPSQFTRVM 479
                   P+  A   +P+  T  +
Sbjct: 560 LPQQPPLPPSQPAFSQVPASSTSTL 584



 Score = 33.9 bits (76), Expect = 0.52
 Identities = 40/195 (20%), Positives = 74/195 (37%), Gaps = 18/195 (9%)

Query: 304  VPSWLKSLRLHKYAALFSQMSY--EEMMTLTEQHLESQNVTKGARHKIALSIQKLRERQS 361
            +P   + L +H    +  Q+    + +  LTE   + Q+    A  +   S+++      
Sbjct: 1131 IPQMAQLLNIHSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEE---SLKEAPSAPV 1187

Query: 362  VLKSLEKDVLEGGNLRNALQELQQIIITPIKAYSVLQATVAAATTTPTAKDGAPGEPPLP 421
            +L S E+  LE  +    +Q +  ++++ +        ++    +   +    P   P  
Sbjct: 1188 ILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTM 1247

Query: 422  GAEPPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPAPAPVADGDIPSQFTRVMGK 481
              E   A P      E K PP     PPP          P P P+ +GD+ S    +   
Sbjct: 1248 PQEEAAACPPHILPPE-KRPPEPPGPPPP----------PPPPPLVEGDLSSAPQELNPA 1296

Query: 482  VCTQL--LVSRPDEE 494
            V   L  L+S+P+ E
Sbjct: 1297 VTAALLQLLSQPEAE 1311


>gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]
          Length = 1096

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 41/154 (26%), Positives = 59/154 (38%), Gaps = 15/154 (9%)

Query: 325 YEEMMTLTEQHLESQNVTKGARHKIALSIQKLRERQSVLKSLEKDVLEGGNLRNALQELQ 384
           Y + + +   HL    V K    K+  S QK  E     K  +++       +  LQ+  
Sbjct: 469 YRQRLDIDLTHLIDSCVNKA---KVEESEQKAAEFS---KKFDEEFTARQEAQAELQKRD 522

Query: 385 QIIITPIKAYSVLQATVAAATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPP-- 442
           + I   ++A      T A   ++ +   G P  PPLPG  PP   P       A  PP  
Sbjct: 523 EKI-KELEAEIQQLRTQAQVLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPP 581

Query: 443 ----AVENYPPPPAPAPTDGSEPAPAPVADGDIP 472
                +   PPPP P    G  P P P+  G +P
Sbjct: 582 PPLPGMMGIPPPPPPPLLFGGPPPPPPL--GGVP 613


>gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]
          Length = 1101

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 41/154 (26%), Positives = 59/154 (38%), Gaps = 15/154 (9%)

Query: 325 YEEMMTLTEQHLESQNVTKGARHKIALSIQKLRERQSVLKSLEKDVLEGGNLRNALQELQ 384
           Y + + +   HL    V K    K+  S QK  E     K  +++       +  LQ+  
Sbjct: 469 YRQRLDIDLTHLIDSCVNKA---KVEESEQKAAEFS---KKFDEEFTARQEAQAELQKRD 522

Query: 385 QIIITPIKAYSVLQATVAAATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPP-- 442
           + I   ++A      T A   ++ +   G P  PPLPG  PP   P       A  PP  
Sbjct: 523 EKI-KELEAEIQQLRTQAQVLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPP 581

Query: 443 ----AVENYPPPPAPAPTDGSEPAPAPVADGDIP 472
                +   PPPP P    G  P P P+  G +P
Sbjct: 582 PPLPGMMGIPPPPPPPLLFGGPPPPPPL--GGVP 613


>gi|41350201 epsin 1 isoform c [Homo sapiens]
          Length = 550

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 31/110 (28%), Positives = 45/110 (40%), Gaps = 10/110 (9%)

Query: 373 GGNLRNALQELQQIIITPIKAYSVLQ----ATVAAATTTPTAKDGAPGEPPLPGAEPPLA 428
           GG   ++L +L  +   P  A +       A +AAA  T        G PP+P A  P  
Sbjct: 225 GGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWG 284

Query: 429 HPGTDKGT------EAKDPPAVENYPPPPAPAPTDGSEPAPAPVADGDIP 472
            P     +       A   P+V+ +   PAPA  +G  P P   +DG +P
Sbjct: 285 GPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVP 334


>gi|194272148 epsin 1 isoform a [Homo sapiens]
          Length = 662

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 31/110 (28%), Positives = 45/110 (40%), Gaps = 10/110 (9%)

Query: 373 GGNLRNALQELQQIIITPIKAYSVLQ----ATVAAATTTPTAKDGAPGEPPLPGAEPPLA 428
           GG   ++L +L  +   P  A +       A +AAA  T        G PP+P A  P  
Sbjct: 336 GGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWG 395

Query: 429 HPGTDKGT------EAKDPPAVENYPPPPAPAPTDGSEPAPAPVADGDIP 472
            P     +       A   P+V+ +   PAPA  +G  P P   +DG +P
Sbjct: 396 GPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVP 445


>gi|112421108 capicua homolog [Homo sapiens]
          Length = 1608

 Score = 41.2 bits (95), Expect = 0.003
 Identities = 70/314 (22%), Positives = 105/314 (33%), Gaps = 53/314 (16%)

Query: 199  GHVPFHPSSSVPPAINSIGSN-----------------ANTGLPCQIHPSPLKRSMSLIP 241
            G  P  PS +  PA+   GS+                 A TG   ++ P PLK++   + 
Sbjct: 1287 GEPPTPPSPAPAPAVAPGGSSESSSGRAAGDTPERKEAAGTGKKVKVRPPPLKKTFDSVD 1346

Query: 242  TSPQVPGEWPSPEELGARAAFTTPDHAPLSPQSSVASSGSEQTEEQGSSRNTFQEDGSGM 301
               +V  E    E       F   +  P     S+A+S           R    +  S  
Sbjct: 1347 N--RVLSEVDFEERFAELPEFRPEEVLPSPTLQSLATSPRAILGSYRKKRKNSTDLDSAP 1404

Query: 302  KDVPSWLKSLRLHKYAALF-----SQMSYEEMMTLTEQHLESQNVTKGARH-KIALSIQK 355
            +D  S  + +R     +       S     ++ T      E+++V     + K+  S  +
Sbjct: 1405 EDPTSPKRKMRRRSSCSSEPNTPKSAKCEGDIFTFDRTGTEAEDVLGELEYDKVPYSSLR 1464

Query: 356  --LRERQSVLKSLEKD--VLEGGNLRNALQE-----LQQIIITPIKAYSVLQATVAAATT 406
              L +R++++  L +D           A Q          +   +K   V Q  + AAT 
Sbjct: 1465 RTLDQRRALVMQLFQDHGFFPSAQATAAFQARYADIFPSKVCLQLKIREVRQKIMQAATP 1524

Query: 407  T--------------PTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYPPPPA 452
            T              PT    AP   P P   P    P +D GT    PP     PPPP 
Sbjct: 1525 TEQPPGAEAPLPVPPPTGTAAAPAPTPSPAGGPDPTSPSSDSGTAQAAPP----LPPPPE 1580

Query: 453  PAP-TDGSEPAPAP 465
              P   G E AP P
Sbjct: 1581 SGPGQPGWEGAPQP 1594



 Score = 30.8 bits (68), Expect = 4.4
 Identities = 27/89 (30%), Positives = 34/89 (38%), Gaps = 24/89 (26%)

Query: 405  TTTPTAKDGAPGEPP----------------LPGAEPPLAHPGTDKGTEAKDPPAVENYP 448
            T TPTA+   P  PP                 P +      PG  +G E +  P     P
Sbjct: 1238 TWTPTARSSPPLPPPAEERTSAKGPETMASKFPSSSSDWRVPG--QGLENRGEPPT---P 1292

Query: 449  PPPAPAPT---DGSEPAPAPVADGDIPSQ 474
            P PAPAP     GS  + +  A GD P +
Sbjct: 1293 PSPAPAPAVAPGGSSESSSGRAAGDTPER 1321


>gi|24497513 homeobox A3 isoform a [Homo sapiens]
          Length = 443

 Score = 40.8 bits (94), Expect = 0.004
 Identities = 73/296 (24%), Positives = 113/296 (38%), Gaps = 57/296 (19%)

Query: 392 KAYSVLQA---TVAAATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYP 448
           KA+ + +A   T++A  + P +    P  PP P A PP   P       A  PPA     
Sbjct: 63  KAHELSEACLRTLSAPPSQPPSLGEPPLHPPPPQAAPPAPQP----PQPAPQPPAPTPAA 118

Query: 449 PPP----APAPTDGSEPAPAPVADGDIPSQFTRVMGKVCTQLLVSRPDEENITSYLQLIE 504
           PPP    +P     + P PA  A   + +  T V  ++   +  SR + +  TS     E
Sbjct: 119 PPPPSSASPPQNASNNPTPANAAKSPLLNSPT-VAKQIFPWMKESRQNTKQKTSSSSSGE 177

Query: 505 KCLTHEA---FTETQKKRLLSWKQQVLKLLRTFP------RKAALEMQNY-----RQQKG 550
            C   ++      +++ R      Q+++L + F       R   +EM N      RQ K 
Sbjct: 178 SCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKI 237

Query: 551 WAFGSNSLPIAGSVGMGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGVSPRHALTSPSL 610
           W F +  +           ++ Q+              G+L+ S  GG SP  +   P  
Sbjct: 238 W-FQNRRMKY---------KKDQK------------GKGMLTSS--GGQSPSRSPVPPGA 273

Query: 611 GG--QGRQNLWFANPGGSNSMPSQSRSSVQRTHSLPVHSSPQAILMFPPDCPVPGP 664
           GG      +L  + P    S P  S+   Q T+ LP  S P ++    P C  P P
Sbjct: 274 GGYLNSMHSLVNSVPYEPQSPPPFSKPP-QGTYGLPPASYPASL----PSCAPPPP 324


>gi|13562112 homeobox A3 isoform a [Homo sapiens]
          Length = 443

 Score = 40.8 bits (94), Expect = 0.004
 Identities = 73/296 (24%), Positives = 113/296 (38%), Gaps = 57/296 (19%)

Query: 392 KAYSVLQA---TVAAATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYP 448
           KA+ + +A   T++A  + P +    P  PP P A PP   P       A  PPA     
Sbjct: 63  KAHELSEACLRTLSAPPSQPPSLGEPPLHPPPPQAAPPAPQP----PQPAPQPPAPTPAA 118

Query: 449 PPP----APAPTDGSEPAPAPVADGDIPSQFTRVMGKVCTQLLVSRPDEENITSYLQLIE 504
           PPP    +P     + P PA  A   + +  T V  ++   +  SR + +  TS     E
Sbjct: 119 PPPPSSASPPQNASNNPTPANAAKSPLLNSPT-VAKQIFPWMKESRQNTKQKTSSSSSGE 177

Query: 505 KCLTHEA---FTETQKKRLLSWKQQVLKLLRTFP------RKAALEMQNY-----RQQKG 550
            C   ++      +++ R      Q+++L + F       R   +EM N      RQ K 
Sbjct: 178 SCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKI 237

Query: 551 WAFGSNSLPIAGSVGMGVARRTQRQFPMPPRALPPGRMGLLSPSGIGGVSPRHALTSPSL 610
           W F +  +           ++ Q+              G+L+ S  GG SP  +   P  
Sbjct: 238 W-FQNRRMKY---------KKDQK------------GKGMLTSS--GGQSPSRSPVPPGA 273

Query: 611 GG--QGRQNLWFANPGGSNSMPSQSRSSVQRTHSLPVHSSPQAILMFPPDCPVPGP 664
           GG      +L  + P    S P  S+   Q T+ LP  S P ++    P C  P P
Sbjct: 274 GGYLNSMHSLVNSVPYEPQSPPPFSKPP-QGTYGLPPASYPASL----PSCAPPPP 324


>gi|56682953 epidermal growth factor receptor pathway substrate 8
           [Homo sapiens]
          Length = 822

 Score = 40.8 bits (94), Expect = 0.004
 Identities = 23/67 (34%), Positives = 28/67 (41%), Gaps = 4/67 (5%)

Query: 415 PGEPPLPGAEPPLAHP----GTDKGTEAKDPPAVENYPPPPAPAPTDGSEPAPAPVADGD 470
           P E  L  A+PP  H       + G    D P   + PP PAP P       PAPV    
Sbjct: 590 PPESGLGRADPPYTHTIQKQRMEYGPRPADTPPAPSPPPTPAPVPVPLPPSTPAPVPVSK 649

Query: 471 IPSQFTR 477
           +P+  TR
Sbjct: 650 VPANITR 656


>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
          Length = 1263

 Score = 40.4 bits (93), Expect = 0.006
 Identities = 38/153 (24%), Positives = 56/153 (36%), Gaps = 20/153 (13%)

Query: 322 QMSYEEMMTLTEQHLESQNVTKGARHKIALSIQKLRERQSVLKSLEKDVLEGGNLRNALQ 381
           Q+  ++M +  EQ L+     K A H          E+Q +    +    E   L   + 
Sbjct: 490 QVEMKKMESDFEQKLQDLQGEKDALHS---------EKQQIATEKQDLEAEVSQLTGEVA 540

Query: 382 ELQQIIITPIKAYSVLQATVAAATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDP 441
           +L + +    K  + L A       +  ++   P  PPLPG          D GT    P
Sbjct: 541 KLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPG----------DSGTIIPPP 590

Query: 442 PAV-ENYPPPPAPAPTDGSEPAPAPVADGDIPS 473
           PA  ++  PPP P P     P P  V     PS
Sbjct: 591 PAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPS 623



 Score = 38.1 bits (87), Expect = 0.028
 Identities = 22/68 (32%), Positives = 28/68 (41%), Gaps = 2/68 (2%)

Query: 404 ATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYP--PPPAPAPTDGSEP 461
           +TT P      P  PPLPG     + P    GT    PP +      PPP P P     P
Sbjct: 596 STTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIP 655

Query: 462 APAPVADG 469
           +P+ +  G
Sbjct: 656 SPSSLPGG 663



 Score = 37.0 bits (84), Expect = 0.062
 Identities = 27/81 (33%), Positives = 32/81 (39%), Gaps = 10/81 (12%)

Query: 397 LQATVAAATTTPTAKDGA-PGEPPLP---GAEPPLAHPGTDKGTEAKDPPAVEN---YPP 449
           L    A +   P + D   P  PPLP   G   P + PG   GT    PP +      PP
Sbjct: 624 LPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPG---GTAIPPPPPLPGSARIPP 680

Query: 450 PPAPAPTDGSEPAPAPVADGD 470
           PP P P     P P P   G+
Sbjct: 681 PPPPLPGSAGIPPPPPPLPGE 701



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 21/61 (34%), Positives = 24/61 (39%), Gaps = 4/61 (6%)

Query: 413 GAPGEPPLPGAE---PPLAHPGTDKGTEAKDP-PAVENYPPPPAPAPTDGSEPAPAPVAD 468
           G P    LPG     PP   PG+ +      P P     PPPP P P +   P P P   
Sbjct: 653 GIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLP 712

Query: 469 G 469
           G
Sbjct: 713 G 713



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 22/60 (36%), Positives = 24/60 (40%), Gaps = 5/60 (8%)

Query: 415 PGEPPLPGAE----PPLAHPGTDKGTEAKDP-PAVENYPPPPAPAPTDGSEPAPAPVADG 469
           P  PPLPG+     PP   PG+        P P     PPPP P P     P P P   G
Sbjct: 667 PPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGG 726



 Score = 30.8 bits (68), Expect = 4.4
 Identities = 18/53 (33%), Positives = 21/53 (39%), Gaps = 2/53 (3%)

Query: 415 PGEPPLPGAE--PPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPAPAP 465
           P  PPLPG+   PP   P   +      PP +   P  P P P  G    P P
Sbjct: 680 PPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPP 732



 Score = 30.4 bits (67), Expect = 5.8
 Identities = 34/139 (24%), Positives = 51/139 (36%), Gaps = 21/139 (15%)

Query: 415 PGEPPLPGAE---PPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPAPAPVADGDI 471
           P  PPLPG     PP   PG   G     PP     PPPP   P     PA   +  G  
Sbjct: 706 PPPPPLPGGPGIPPPPPFPG---GPGIPPPPPGMGMPPPP---PFGFGVPAAPVLPFGLT 759

Query: 472 PSQFTRVMGKVCTQLLVSRPDEENITSYLQLIEKCLTHEAFTETQKKRLLSWKQQVLKLL 531
           P +  +       ++ + RP      ++ +L+ + L+ + F    K+      +   KL 
Sbjct: 760 PKKLYK------PEVQLRRP------NWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLT 807

Query: 532 RTFPRKAALEMQNYRQQKG 550
            TF  +         Q+ G
Sbjct: 808 LTFSAQTKTSKAKKDQEGG 826


>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
          Length = 1272

 Score = 40.4 bits (93), Expect = 0.006
 Identities = 38/153 (24%), Positives = 56/153 (36%), Gaps = 20/153 (13%)

Query: 322 QMSYEEMMTLTEQHLESQNVTKGARHKIALSIQKLRERQSVLKSLEKDVLEGGNLRNALQ 381
           Q+  ++M +  EQ L+     K A H          E+Q +    +    E   L   + 
Sbjct: 499 QVEMKKMESDFEQKLQDLQGEKDALHS---------EKQQIATEKQDLEAEVSQLTGEVA 549

Query: 382 ELQQIIITPIKAYSVLQATVAAATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDP 441
           +L + +    K  + L A       +  ++   P  PPLPG          D GT    P
Sbjct: 550 KLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPG----------DSGTIIPPP 599

Query: 442 PAV-ENYPPPPAPAPTDGSEPAPAPVADGDIPS 473
           PA  ++  PPP P P     P P  V     PS
Sbjct: 600 PAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPS 632



 Score = 38.1 bits (87), Expect = 0.028
 Identities = 22/68 (32%), Positives = 28/68 (41%), Gaps = 2/68 (2%)

Query: 404 ATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYP--PPPAPAPTDGSEP 461
           +TT P      P  PPLPG     + P    GT    PP +      PPP P P     P
Sbjct: 605 STTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIP 664

Query: 462 APAPVADG 469
           +P+ +  G
Sbjct: 665 SPSSLPGG 672



 Score = 37.0 bits (84), Expect = 0.062
 Identities = 27/81 (33%), Positives = 32/81 (39%), Gaps = 10/81 (12%)

Query: 397 LQATVAAATTTPTAKDGA-PGEPPLP---GAEPPLAHPGTDKGTEAKDPPAVEN---YPP 449
           L    A +   P + D   P  PPLP   G   P + PG   GT    PP +      PP
Sbjct: 633 LPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPG---GTAIPPPPPLPGSARIPP 689

Query: 450 PPAPAPTDGSEPAPAPVADGD 470
           PP P P     P P P   G+
Sbjct: 690 PPPPLPGSAGIPPPPPPLPGE 710



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 21/61 (34%), Positives = 24/61 (39%), Gaps = 4/61 (6%)

Query: 413 GAPGEPPLPGAE---PPLAHPGTDKGTEAKDP-PAVENYPPPPAPAPTDGSEPAPAPVAD 468
           G P    LPG     PP   PG+ +      P P     PPPP P P +   P P P   
Sbjct: 662 GIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLP 721

Query: 469 G 469
           G
Sbjct: 722 G 722



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 22/60 (36%), Positives = 24/60 (40%), Gaps = 5/60 (8%)

Query: 415 PGEPPLPGAE----PPLAHPGTDKGTEAKDP-PAVENYPPPPAPAPTDGSEPAPAPVADG 469
           P  PPLPG+     PP   PG+        P P     PPPP P P     P P P   G
Sbjct: 676 PPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGG 735



 Score = 30.8 bits (68), Expect = 4.4
 Identities = 18/53 (33%), Positives = 21/53 (39%), Gaps = 2/53 (3%)

Query: 415 PGEPPLPGAE--PPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPAPAP 465
           P  PPLPG+   PP   P   +      PP +   P  P P P  G    P P
Sbjct: 689 PPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPP 741



 Score = 30.4 bits (67), Expect = 5.8
 Identities = 34/139 (24%), Positives = 51/139 (36%), Gaps = 21/139 (15%)

Query: 415 PGEPPLPGAE---PPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPAPAPVADGDI 471
           P  PPLPG     PP   PG   G     PP     PPPP   P     PA   +  G  
Sbjct: 715 PPPPPLPGGPGIPPPPPFPG---GPGIPPPPPGMGMPPPP---PFGFGVPAAPVLPFGLT 768

Query: 472 PSQFTRVMGKVCTQLLVSRPDEENITSYLQLIEKCLTHEAFTETQKKRLLSWKQQVLKLL 531
           P +  +       ++ + RP      ++ +L+ + L+ + F    K+      +   KL 
Sbjct: 769 PKKLYK------PEVQLRRP------NWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLT 816

Query: 532 RTFPRKAALEMQNYRQQKG 550
            TF  +         Q+ G
Sbjct: 817 LTFSAQTKTSKAKKDQEGG 835


>gi|148536848 carboxyl ester lipase precursor [Homo sapiens]
          Length = 756

 Score = 40.4 bits (93), Expect = 0.006
 Identities = 30/97 (30%), Positives = 32/97 (32%), Gaps = 21/97 (21%)

Query: 403 AATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYPP------------- 449
           A    PT   GAP  PP   A PP   P  D G     P      PP             
Sbjct: 659 APPVPPTGDSGAPPVPPTGDAGPPPVPPTGDSGAPPVPPTGDSGAPPVTPTGDSETAPVP 718

Query: 450 -------PPAPAPTDGSEPAPAPVADGDIPSQFTRVM 479
                  PP P PT  SE AP P  D    +Q   V+
Sbjct: 719 PTGDSGAPPVP-PTGDSEAAPVPPTDDSKEAQMPAVI 754



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 24/70 (34%), Positives = 27/70 (38%), Gaps = 2/70 (2%)

Query: 403 AATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPA 462
           A    PT   GAP  PP   +  P   P  D G     PP  +  PPP  P    G+ P 
Sbjct: 637 APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV-PPTGDAGPPPVPPTGDSGAPPV 695

Query: 463 PAPVADGDIP 472
           P P  D   P
Sbjct: 696 P-PTGDSGAP 704



 Score = 38.5 bits (88), Expect = 0.021
 Identities = 37/130 (28%), Positives = 47/130 (36%), Gaps = 10/130 (7%)

Query: 351 LSIQKLRERQSVLKSLEKDVLEGGNLRN-ALQELQQIIITPIKAYSVLQATVAAAT---- 405
           L I K     S+ +SL  + L    L   AL  +     TP+      +AT    T    
Sbjct: 522 LEITKKMGSSSMKRSLRTNFLRYWTLTYLALPTVTDQEATPVPPTGDSEATPVPPTGDSE 581

Query: 406 ---TTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPA 462
                PT   GAP  PP   +  P   P  D G     PP  ++  PP  P    G+ P 
Sbjct: 582 TAPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV-PPTGDSGAPPVPPTGDSGAPPV 640

Query: 463 PAPVADGDIP 472
           P P  D   P
Sbjct: 641 P-PTGDSGAP 649



 Score = 37.4 bits (85), Expect = 0.047
 Identities = 23/70 (32%), Positives = 27/70 (38%), Gaps = 2/70 (2%)

Query: 403 AATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPA 462
           A    PT   GAP  PP   +  P   P  D G     PP  ++  PP  P    G+ P 
Sbjct: 593 APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV-PPTGDSGAPPVPPTGDSGAPPV 651

Query: 463 PAPVADGDIP 472
           P P  D   P
Sbjct: 652 P-PTGDSGAP 660



 Score = 37.4 bits (85), Expect = 0.047
 Identities = 23/70 (32%), Positives = 27/70 (38%), Gaps = 2/70 (2%)

Query: 403 AATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPA 462
           A    PT   GAP  PP   +  P   P  D G     PP  ++  PP  P    G+ P 
Sbjct: 604 APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV-PPTGDSGAPPVPPTGDSGAPPV 662

Query: 463 PAPVADGDIP 472
           P P  D   P
Sbjct: 663 P-PTGDSGAP 671



 Score = 36.6 bits (83), Expect = 0.080
 Identities = 23/70 (32%), Positives = 27/70 (38%), Gaps = 2/70 (2%)

Query: 403 AATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPA 462
           A    PT   GAP  PP   +  P   P  D G     PP  ++  PP  P    G+ P 
Sbjct: 615 APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDSGAPPV-PPTGDSGAPPVPPTGDSGAPPV 673

Query: 463 PAPVADGDIP 472
           P P  D   P
Sbjct: 674 P-PTGDAGPP 682



 Score = 33.9 bits (76), Expect = 0.52
 Identities = 24/72 (33%), Positives = 27/72 (37%), Gaps = 10/72 (13%)

Query: 403 AATTTPTAKDGAPGEPPLPGAEPPLAHPGTDKGTEAKDPPAVENYPPP---------PAP 453
           A    PT   GAP  PP   +  P   P  D G     PP  ++  PP         P  
Sbjct: 648 APPVPPTGDSGAPPVPPTGDSGAPPVPPTGDAGPPPV-PPTGDSGAPPVPPTGDSGAPPV 706

Query: 454 APTDGSEPAPAP 465
            PT  SE AP P
Sbjct: 707 TPTGDSETAPVP 718


>gi|29826321 adducin 1 (alpha) isoform b [Homo sapiens]
          Length = 768

 Score = 40.4 bits (93), Expect = 0.006
 Identities = 31/90 (34%), Positives = 38/90 (42%), Gaps = 13/90 (14%)

Query: 389 TPIKAYSVLQATVAAATTTPTAKDGAPGEPPLPGAEPP-----LAHPGTDKGTEAKDPPA 443
           TPIK    L+  +    TT    D A  +P LP   P      L  P  +K  EA  PP+
Sbjct: 645 TPIK----LEEDLVPEPTTGDDSDAATFKPTLPDLSPDEPSEALGFPMLEKEEEAHRPPS 700

Query: 444 VENYPPPPAPAPTDGSEPAPAPVADGDIPS 473
               P   +P P     P PAPVA+   PS
Sbjct: 701 PTEAPTEASPEPA----PDPAPVAEEAAPS 726



 Score = 30.0 bits (66), Expect = 7.5
 Identities = 27/75 (36%), Positives = 32/75 (42%), Gaps = 16/75 (21%)

Query: 403 AATTTPTAKDGAPGEP------PLPGAEPPLAHPG--TDKGTEAKDPPAVENYPPPPAPA 454
           AAT  PT  D +P EP      P+   E     P   T+  TEA   PA     P PAP 
Sbjct: 665 AATFKPTLPDLSPDEPSEALGFPMLEKEEEAHRPPSPTEAPTEASPEPA-----PDPAPV 719

Query: 455 PTDGSEPAPAPVADG 469
                E AP+ V +G
Sbjct: 720 ---AEEAAPSAVEEG 731


>gi|29826319 adducin 1 (alpha) isoform a [Homo sapiens]
          Length = 737

 Score = 40.4 bits (93), Expect = 0.006
 Identities = 31/90 (34%), Positives = 38/90 (42%), Gaps = 13/90 (14%)

Query: 389 TPIKAYSVLQATVAAATTTPTAKDGAPGEPPLPGAEPP-----LAHPGTDKGTEAKDPPA 443
           TPIK    L+  +    TT    D A  +P LP   P      L  P  +K  EA  PP+
Sbjct: 614 TPIK----LEEDLVPEPTTGDDSDAATFKPTLPDLSPDEPSEALGFPMLEKEEEAHRPPS 669

Query: 444 VENYPPPPAPAPTDGSEPAPAPVADGDIPS 473
               P   +P P     P PAPVA+   PS
Sbjct: 670 PTEAPTEASPEPA----PDPAPVAEEAAPS 695



 Score = 30.0 bits (66), Expect = 7.5
 Identities = 27/75 (36%), Positives = 32/75 (42%), Gaps = 16/75 (21%)

Query: 403 AATTTPTAKDGAPGEP------PLPGAEPPLAHPG--TDKGTEAKDPPAVENYPPPPAPA 454
           AAT  PT  D +P EP      P+   E     P   T+  TEA   PA     P PAP 
Sbjct: 634 AATFKPTLPDLSPDEPSEALGFPMLEKEEEAHRPPSPTEAPTEASPEPA-----PDPAPV 688

Query: 455 PTDGSEPAPAPVADG 469
                E AP+ V +G
Sbjct: 689 ---AEEAAPSAVEEG 700


>gi|4507691 transformation/transcription domain-associated protein
           [Homo sapiens]
          Length = 3830

 Score = 40.4 bits (93), Expect = 0.006
 Identities = 28/103 (27%), Positives = 37/103 (35%), Gaps = 15/103 (14%)

Query: 368 KDVLEGGNLRNALQELQQIIITPIKAYSVLQATVAAATTTPTAKDGA-----PGEPPLPG 422
           K   E GN R+ L  + ++ +      +  Q +       P ++ GA     PG P  P 
Sbjct: 433 KSEQESGNGRDVLMRMLEVFVLKFHTIARYQLSAIFKKCKPQSELGAVEAALPGVPTAPA 492

Query: 423 AEPPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPAPAP 465
           A  P   P           P     PPPP P P     PAP P
Sbjct: 493 APGPAPSPA----------PVPAPPPPPPPPPPATPVTPAPVP 525


>gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo
           sapiens]
          Length = 2462

 Score = 40.4 bits (93), Expect = 0.006
 Identities = 49/220 (22%), Positives = 77/220 (35%), Gaps = 16/220 (7%)

Query: 255 ELGARAAFTTPDHAPLSPQSSVASSGSEQTEEQGSSRNTFQEDGSGMKDVPSWLKSLRLH 314
           E  +  A T    A L+      SS   + EE  +++    E G     +   + S  + 
Sbjct: 589 EANSEEAITPQQSAELASMELNESSRWTE-EEMETAKKGLLEHGRNWSAIARMVGSKTVS 647

Query: 315 KYAAL-FSQMSYEEMMTLTEQHLESQNVTKGARHKIALSIQKLRERQSVLKSLEKDVLEG 373
           +     F+    + +  + +QH       + AR K   +     E  +    +E + +E 
Sbjct: 648 QCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEA 707

Query: 374 ----GNLRNALQELQQIIITPIKAYSVLQATVAAATTT------PTAKDGAPGEPPLPGA 423
               GN    ++E +  +       S+      AA  T      P A  GA G PP P  
Sbjct: 708 SGVSGNEEEMVEEAEATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPT 767

Query: 424 EPPLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEPAP 463
            PP   P   + T A +        P P PAP   S P P
Sbjct: 768 PPPEDIPAPTEPTPASEATGA----PTPPPAPPSPSAPPP 803



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 30/101 (29%), Positives = 41/101 (40%), Gaps = 13/101 (12%)

Query: 373  GGNLRNALQELQQIIITPIKAYSVLQATVAAATT------TPTAKDGA-PGEPPLPGAEP 425
            GG L      L + ++ P +A  V +     A T       P A+ G  P   P  G+EP
Sbjct: 1913 GGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEP 1972

Query: 426  -----PLAHPGTDKGTEAKDPPAVENYPPPPAPAPTDGSEP 461
                 P++   T   T AK+       P PPAP P   S+P
Sbjct: 1973 RPLVPPVSGHATIARTPAKNLAPHHASPDPPAP-PASASDP 2012


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.130    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,831,157
Number of Sequences: 37866
Number of extensions: 2000453
Number of successful extensions: 18798
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 207
Number of HSP's successfully gapped in prelim test: 780
Number of HSP's that attempted gapping in prelim test: 11412
Number of HSP's gapped (non-prelim): 6554
length of query: 694
length of database: 18,247,518
effective HSP length: 109
effective length of query: 585
effective length of database: 14,120,124
effective search space: 8260272540
effective search space used: 8260272540
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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