Search of human proteins with 55741641

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
         (1771 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...  3540   0.0  
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   214   6e-55
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       196   2e-49
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        196   2e-49
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        196   2e-49
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        196   2e-49
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        196   2e-49
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   184   5e-46
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   184   5e-46
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       184   7e-46
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        184   7e-46
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        184   7e-46
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...   184   7e-46
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                    184   7e-46
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        177   6e-44
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ...   167   1e-40
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ...   167   1e-40
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   166   1e-40
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   165   4e-40
gi|89363047 death-associated protein kinase 1 [Homo sapiens]          153   2e-36
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   150   1e-35
gi|70995267 ankyrin repeat domain 29 [Homo sapiens]                   150   1e-35
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled...   143   1e-33
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled...   143   1e-33
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho...   140   1e-32
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  140   1e-32
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled...   140   1e-32
gi|34304381 inversin isoform a [Homo sapiens]                         139   2e-32
gi|34304379 inversin isoform b [Homo sapiens]                         139   2e-32
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ...   139   3e-32

>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapiens]
          Length = 1771

 Score = 3540 bits (9180), Expect = 0.0
 Identities = 1771/1771 (100%), Positives = 1771/1771 (100%)

Query: 1    MSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKN 60
            MSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKN
Sbjct: 1    MSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKN 60

Query: 61   GANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVV 120
            GANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVV
Sbjct: 61   GANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVV 120

Query: 121  ELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARK 180
            ELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARK
Sbjct: 121  ELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARK 180

Query: 181  GHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTAL 240
            GHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTAL
Sbjct: 181  GHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTAL 240

Query: 241  MIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQ 300
            MIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQ
Sbjct: 241  MIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQ 300

Query: 301  DNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAK 360
            DNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAK
Sbjct: 301  DNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAK 360

Query: 361  VSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILT 420
            VSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILT
Sbjct: 361  VSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILT 420

Query: 421  QIFGARHLSPTETDGDMLGYDLYSSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLE 480
            QIFGARHLSPTETDGDMLGYDLYSSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLE
Sbjct: 421  QIFGARHLSPTETDGDMLGYDLYSSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLE 480

Query: 481  DEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFLALLYIFF 540
            DEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFLALLYIFF
Sbjct: 481  DEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFLALLYIFF 540

Query: 541  IVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFT 600
            IVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFT
Sbjct: 541  IVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFT 600

Query: 601  DYNRLSSVGGETSLAEMIATLSDACEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSF 660
            DYNRLSSVGGETSLAEMIATLSDACEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSF
Sbjct: 601  DYNRLSSVGGETSLAEMIATLSDACEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSF 660

Query: 661  VIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQVLDSLLN 720
            VIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQVLDSLLN
Sbjct: 661  VIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQVLDSLLN 720

Query: 721  SQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACE 780
            SQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACE
Sbjct: 721  SQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACE 780

Query: 781  QDKVLQMLDTVRVLFSKGPFIAIFASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHL 840
            QDKVLQMLDTVRVLFSKGPFIAIFASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHL
Sbjct: 781  QDKVLQMLDTVRVLFSKGPFIAIFASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHL 840

Query: 841  PVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLGSKTALNR 900
            PVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLGSKTALNR
Sbjct: 841  PVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLGSKTALNR 900

Query: 901  RDTYRRRQMQRTITRQMSFDLTKLLVTEDWFSDISPQTMRRLLNIVSVTGRLLRANQISF 960
            RDTYRRRQMQRTITRQMSFDLTKLLVTEDWFSDISPQTMRRLLNIVSVTGRLLRANQISF
Sbjct: 901  RDTYRRRQMQRTITRQMSFDLTKLLVTEDWFSDISPQTMRRLLNIVSVTGRLLRANQISF 960

Query: 961  NWDRLASWINLTEQWPYRTSWLILYLEETEGIPDQMTLKTIYERISKNIPTTKDVEPLLE 1020
            NWDRLASWINLTEQWPYRTSWLILYLEETEGIPDQMTLKTIYERISKNIPTTKDVEPLLE
Sbjct: 961  NWDRLASWINLTEQWPYRTSWLILYLEETEGIPDQMTLKTIYERISKNIPTTKDVEPLLE 1020

Query: 1021 IDGDIRNFEVFLSSRTPVLVARDVKVFLPCTVNLDPKLREIIADVRAAREQISIGGLAYP 1080
            IDGDIRNFEVFLSSRTPVLVARDVKVFLPCTVNLDPKLREIIADVRAAREQISIGGLAYP
Sbjct: 1021 IDGDIRNFEVFLSSRTPVLVARDVKVFLPCTVNLDPKLREIIADVRAAREQISIGGLAYP 1080

Query: 1081 PLPLHEGPPRAPSGYSQPPSVCSSTSFNGPFAGGVVSPQPHSSYYSGMTGPQHPFYNRPF 1140
            PLPLHEGPPRAPSGYSQPPSVCSSTSFNGPFAGGVVSPQPHSSYYSGMTGPQHPFYNRPF
Sbjct: 1081 PLPLHEGPPRAPSGYSQPPSVCSSTSFNGPFAGGVVSPQPHSSYYSGMTGPQHPFYNRPF 1140

Query: 1141 FAPYLYTPRYYPGGSQHLISRPSVKTSLPRDQNNGLEVIKEDAAEGLSSPTDSSRGSGPA 1200
            FAPYLYTPRYYPGGSQHLISRPSVKTSLPRDQNNGLEVIKEDAAEGLSSPTDSSRGSGPA
Sbjct: 1141 FAPYLYTPRYYPGGSQHLISRPSVKTSLPRDQNNGLEVIKEDAAEGLSSPTDSSRGSGPA 1200

Query: 1201 PGPVVLLNSLNVDAVCEKLKQIEGLDQSMLPQYCTTIKKANINGRVLAQCNIDELKKEMN 1260
            PGPVVLLNSLNVDAVCEKLKQIEGLDQSMLPQYCTTIKKANINGRVLAQCNIDELKKEMN
Sbjct: 1201 PGPVVLLNSLNVDAVCEKLKQIEGLDQSMLPQYCTTIKKANINGRVLAQCNIDELKKEMN 1260

Query: 1261 MNFGDWHLFRSTVLEMRNAESHVVPEDPRFLSESSSGPAPHGEPARRASHNELPHTELSS 1320
            MNFGDWHLFRSTVLEMRNAESHVVPEDPRFLSESSSGPAPHGEPARRASHNELPHTELSS
Sbjct: 1261 MNFGDWHLFRSTVLEMRNAESHVVPEDPRFLSESSSGPAPHGEPARRASHNELPHTELSS 1320

Query: 1321 QTPYTLNFSFEELNTLGLDEGAPRHSNLSWQSQTRRTPSLSSLNSQDSSIEISKLTDKVQ 1380
            QTPYTLNFSFEELNTLGLDEGAPRHSNLSWQSQTRRTPSLSSLNSQDSSIEISKLTDKVQ
Sbjct: 1321 QTPYTLNFSFEELNTLGLDEGAPRHSNLSWQSQTRRTPSLSSLNSQDSSIEISKLTDKVQ 1380

Query: 1381 AEYRDAYREYIAQMSQLEGGPGSTTISGRSSPHSTYYMGQSSSGGSIHSNLEQEKGKDSE 1440
            AEYRDAYREYIAQMSQLEGGPGSTTISGRSSPHSTYYMGQSSSGGSIHSNLEQEKGKDSE
Sbjct: 1381 AEYRDAYREYIAQMSQLEGGPGSTTISGRSSPHSTYYMGQSSSGGSIHSNLEQEKGKDSE 1440

Query: 1441 PKPDDGRKSFLMKRGDVIDYSSSGVSTNDASPLDPITEEDEKSDQSGSKLLPGKKSSERS 1500
            PKPDDGRKSFLMKRGDVIDYSSSGVSTNDASPLDPITEEDEKSDQSGSKLLPGKKSSERS
Sbjct: 1441 PKPDDGRKSFLMKRGDVIDYSSSGVSTNDASPLDPITEEDEKSDQSGSKLLPGKKSSERS 1500

Query: 1501 SLFQTDLKLKGSGLRYQKLPSDEDESGTEESDNTPLLKDDKDRKAEGKVERVPKSPEHSA 1560
            SLFQTDLKLKGSGLRYQKLPSDEDESGTEESDNTPLLKDDKDRKAEGKVERVPKSPEHSA
Sbjct: 1501 SLFQTDLKLKGSGLRYQKLPSDEDESGTEESDNTPLLKDDKDRKAEGKVERVPKSPEHSA 1560

Query: 1561 EPIRTFIKAKEYLSDALLDKKDSSDSGVRSSESSPNHSLHNEVADDSQLEKANLIELEDD 1620
            EPIRTFIKAKEYLSDALLDKKDSSDSGVRSSESSPNHSLHNEVADDSQLEKANLIELEDD
Sbjct: 1561 EPIRTFIKAKEYLSDALLDKKDSSDSGVRSSESSPNHSLHNEVADDSQLEKANLIELEDD 1620

Query: 1621 SHSGKRGIPHSLSGLQDPIIARMSICSEDKKSPSECSLIASSPEENWPACQKAYNLNRTP 1680
            SHSGKRGIPHSLSGLQDPIIARMSICSEDKKSPSECSLIASSPEENWPACQKAYNLNRTP
Sbjct: 1621 SHSGKRGIPHSLSGLQDPIIARMSICSEDKKSPSECSLIASSPEENWPACQKAYNLNRTP 1680

Query: 1681 STVTLNNNSAPANRANQNFDEMEGIRETSQVILRPSSSPNPTTIQNENLKSMTHKRSQRS 1740
            STVTLNNNSAPANRANQNFDEMEGIRETSQVILRPSSSPNPTTIQNENLKSMTHKRSQRS
Sbjct: 1681 STVTLNNNSAPANRANQNFDEMEGIRETSQVILRPSSSPNPTTIQNENLKSMTHKRSQRS 1740

Query: 1741 SYTRLSKDPPELHAAASSESTGFGEERESIL 1771
            SYTRLSKDPPELHAAASSESTGFGEERESIL
Sbjct: 1741 SYTRLSKDPPELHAAASSESTGFGEERESIL 1771


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  214 bits (545), Expect = 6e-55
 Identities = 135/380 (35%), Positives = 198/380 (52%), Gaps = 5/380 (1%)

Query: 16  ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
           E   +++ LL+    V++ +  G+T L  AA  G+L++V  L+  GA+  +ED    T L
Sbjct: 523 EREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPL 582

Query: 76  ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135
             A+++GH  +V  L+ CG N+ H D  GWTAL  A + G T+VV  LL  G        
Sbjct: 583 TLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADA 642

Query: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
            S   +  AA  GH DIV  LLQ+GA+VN +D  G T L+ AA  GH E V+HLL  GA+
Sbjct: 643 DSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAE 702

Query: 196 VDQEGANSMTALIVA-----VKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTE 250
           V+ E  +  TAL VA        G+   V  ++ R   V+  DKDG T L++A+ EGH +
Sbjct: 703 VNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVD 762

Query: 251 IVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAV 310
           +V  LL+ G  V+  D +G T L+ A   GH  +V  LL   A +D    + +T L  A 
Sbjct: 763 VVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIAS 822

Query: 311 EKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDT 370
            +GN  +VR +L    D       G TPL  A    +  + E L+++GA+ + +D  G  
Sbjct: 823 AQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRI 882

Query: 371 PLHIAIRGRSRKLAELLLRN 390
           P  +A +       ++LL N
Sbjct: 883 PFILASQEGHYDCVQILLEN 902



 Score =  179 bits (455), Expect = 2e-44
 Identities = 131/390 (33%), Positives = 190/390 (48%), Gaps = 10/390 (2%)

Query: 52  EIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWA 111
           E+++ L+K GA+ N ED D  + ++  + E    I   LL  G ++   D  G T L  A
Sbjct: 495 EVLQLLVKAGAHVNSED-DRTSCIVRQALEREDSI-RTLLDNGASVNQCDSNGRTLLANA 552

Query: 112 CYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGT 171
            Y G  DVV LL+S GA+  +   +   P+  AA +GH  +V+ L+  GA +N +D+ G 
Sbjct: 553 AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGW 612

Query: 172 TPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNL 231
           T L  AA  GH E V  LL  G  VD   A+S TAL  A  GG+   V  +L+    VN 
Sbjct: 613 TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK 672

Query: 232 TDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGA-----VRGGHVEIVR 286
            D +G TAL+ A+  GH EIV+ LLD G  VN  D  G T L  A        GH  +V 
Sbjct: 673 ADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVS 732

Query: 287 ALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMR 346
            L+ + A++D   +D  T L  A  +G+  +V  +L+   D +    +G TPL+ A  M 
Sbjct: 733 LLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMG 792

Query: 347 NIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGET 406
           +  VV  LL  GA V ++D +G T L IA    + ++   LL    D       + AG T
Sbjct: 793 HASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDEN---HRDDAGWT 849

Query: 407 PYNIDCSHQKSILTQIFGARHLSPTETDGD 436
           P ++       ++ +    +     E D D
Sbjct: 850 PLHMAAFEGHRLICEALIEQGARTNEIDND 879



 Score =  174 bits (440), Expect = 9e-43
 Identities = 118/372 (31%), Positives = 189/372 (50%), Gaps = 5/372 (1%)

Query: 24   LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISAS---- 79
            LL+   +V++ +  G+T L+ AA  G+ EIV+ L+ +GA  N ED+D  TAL  A+    
Sbjct: 663  LLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVP 722

Query: 80   -KEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSV 138
              +GH  +V  L+  G  ++H D  G T L+ A Y+G  DVV+LLL  GA+   T     
Sbjct: 723  ASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGR 782

Query: 139  YPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQ 198
             P++ AA  GHA +V+ LL  GA V+  D  G T L  A+ +G++E V+ LL  G D + 
Sbjct: 783  TPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENH 842

Query: 199  EGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDA 258
                  T L +A   G+    + ++++    N  D DG    ++AS+EGH + VQ LL+ 
Sbjct: 843  RDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLEN 902

Query: 259  GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 318
             + ++     G   L  A   GH +IV  L    AD++ +  D +  LY    +   TM 
Sbjct: 903  KSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMA 962

Query: 319  RDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRG 378
               L+   + E    +G T L  +    ++E+V++L+   A V+A D +  + L  A   
Sbjct: 963  EYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQ 1022

Query: 379  RSRKLAELLLRN 390
               K+ +LL+ +
Sbjct: 1023 GHVKVVQLLIEH 1034



 Score =  169 bits (429), Expect = 2e-41
 Identities = 115/384 (29%), Positives = 191/384 (49%), Gaps = 6/384 (1%)

Query: 15   EENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTA 74
            E ++  +  LLE   DVD  +  G+TPL+ AA  G+  +V  L+  GA  +  D +  T 
Sbjct: 758  EGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTV 817

Query: 75   LISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTG 134
            L  AS +G+V +V  LL  G++  HRD  GWT L  A ++G   + E L+  GA  +   
Sbjct: 818  LSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEID 877

Query: 135  LYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGA 194
                 P I A+  GH D V +LL+N + ++     G   L  AA +GH + V+ L + GA
Sbjct: 878  NDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGA 937

Query: 195  DVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQD 254
            DV+ + A+    L +          +  L+   NV  +D +G TAL ++  +GH E+VQ 
Sbjct: 938  DVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQV 997

Query: 255  LLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGN 314
            L+     VN  D    + L  A   GHV++V+ L++  A +D       TAL  A ++G+
Sbjct: 998  LIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGH 1057

Query: 315  ATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHI 374
              +V+ +L+   D     + G T +  A K  + ++++LL   GA  S+++    +P+H 
Sbjct: 1058 IDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA--SSLNGCSPSPVHT 1115

Query: 375  ----AIRGRSRKLAELLLRNPKDG 394
                 ++  S K+  L +++   G
Sbjct: 1116 MEQKPLQSLSSKVQSLTIKSNSSG 1139



 Score =  115 bits (289), Expect = 3e-25
 Identities = 68/211 (32%), Positives = 120/211 (56%)

Query: 14   EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
            +E +   ++ LLE   ++D+R   G+  L +AA +G+ +IV+ L  +GA+ N +D D   
Sbjct: 889  QEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRP 948

Query: 74   ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
             L   + E  + + E  L+ G N+E  D  G TAL  +C++G  ++V++L+++ A+ +  
Sbjct: 949  TLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAA 1008

Query: 134  GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
                   +  AA +GH  +V LL+++GA V+ +   G T L  AA++GH++ V+ LL  G
Sbjct: 1009 DNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHG 1068

Query: 194  ADVDQEGANSMTALIVAVKGGYTQSVKEILK 224
            AD +       TA+ VA K G++Q +K + K
Sbjct: 1069 ADPNHADQFGRTAMRVAAKNGHSQIIKLLEK 1099



 Score = 35.0 bits (79), Expect = 0.65
 Identities = 17/50 (34%), Positives = 32/50 (64%)

Query: 14   EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGAN 63
            +E +I  ++ LLE   D +  ++ G+T + +AA+ G+ +I+K L K GA+
Sbjct: 1054 QEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS 1103


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  196 bits (498), Expect = 2e-49
 Identities = 136/410 (33%), Positives = 204/410 (49%), Gaps = 9/410 (2%)

Query: 24  LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGH 83
           LL+   + D  ++ G TPL IAA   NL + + L+  GA+ N    +  T L  AS+ G+
Sbjct: 225 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 284

Query: 84  VHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIW 143
           V +V  LL  G  +E +     T L  A   G   + E+LL HGA         + PI  
Sbjct: 285 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 344

Query: 144 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203
           AA   H D V LLLQ  A+++       TPL  AA  GH    K LL  GA  +    N 
Sbjct: 345 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 404

Query: 204 MTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN 263
            T L +A K  + + ++ +LK   +++   + G T L +AS  GH  IV++LL  G   N
Sbjct: 405 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 464

Query: 264 IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ 323
           + +   +T L  A R GH E+ + LLQ  A ++ + +D++T L+ A   G+  MV+ +L+
Sbjct: 465 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 524

Query: 324 CNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKL 383
            N +  + T  G TPL  A +  ++E V  LL+K A  + + KKG TPLH+A +    ++
Sbjct: 525 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 584

Query: 384 AELLLRNPKDGRLLYRPNKAGE---TPYNIDCSHQKSILTQIFGARHLSP 430
           AELLL           PN AG+   TP ++   H    + ++   R  SP
Sbjct: 585 AELLLERDA------HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 628



 Score =  185 bits (469), Expect = 4e-46
 Identities = 130/395 (32%), Positives = 197/395 (49%), Gaps = 3/395 (0%)

Query: 16  ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
           EN+   + LL +   V+   + G TPL IA+ +GN+ +V+ L+  GA    +  D  T L
Sbjct: 250 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 309

Query: 76  ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135
             A++ GHV I E LL  G  ++ +   G + +  A      D V LLL + A      L
Sbjct: 310 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL 369

Query: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
             + P+  AA  GH  +  +LL  GAK N     G TPL  A +K H+  ++ LL  GA 
Sbjct: 370 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 429

Query: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
           +D    + +T L VA   G+   VK +L+R  + N+++    T L +A++ GHTE+ + L
Sbjct: 430 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489

Query: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
           L     VN   +   T L  A R GH  +V+ LL+  A+ ++      T L+ A  +G+ 
Sbjct: 490 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 549

Query: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
             V  +L+        TK G TPL  A K   + V ELLL++ A  +A  K G TPLH+A
Sbjct: 550 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 609

Query: 376 IRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 410
           +   +  + +LLL  P+ G   + P   G TP +I
Sbjct: 610 VHHNNLDIVKLLL--PRGGS-PHSPAWNGYTPLHI 641



 Score =  182 bits (463), Expect = 2e-45
 Identities = 130/387 (33%), Positives = 192/387 (49%), Gaps = 3/387 (0%)

Query: 24  LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGH 83
           LL+    +  + + G +P+ +AA+  +L+ V+ L++  A  +   LD+ T L  A+  GH
Sbjct: 324 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 383

Query: 84  VHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIW 143
             + + LL  G     R + G+T L  AC K    V+ELLL  GA+        + P+  
Sbjct: 384 HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV 443

Query: 144 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203
           A+  GH  IV  LLQ GA  N S+    TPL  AAR GH E  K+LL   A V+ +  + 
Sbjct: 444 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 503

Query: 204 MTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN 263
            T L  A + G+T  VK +L+ N N NL    G+T L IA++EGH E V  LL+      
Sbjct: 504 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 563

Query: 264 IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ 323
              + G T L  A + G V +   LL++ A  +  G++  T L+ AV   N  +V+ +L 
Sbjct: 564 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 623

Query: 324 CNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKL 383
                     +G TPL  A K   +EV   LL  G   +A   +G TPLH+A +    ++
Sbjct: 624 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 683

Query: 384 AELLLRNPKDGRLLYRPNKAGETPYNI 410
             LLL    +G L    NK+G TP ++
Sbjct: 684 VALLLSKQANGNL---GNKSGLTPLHL 707



 Score =  178 bits (451), Expect = 5e-44
 Identities = 126/412 (30%), Positives = 206/412 (50%), Gaps = 4/412 (0%)

Query: 16  ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
           +++  ++ LL+   ++D+      TPL +AA  G+  + K L+  GA  N   L+ +T L
Sbjct: 349 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 408

Query: 76  ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135
             A K+ HV ++E LLK G +++     G T L  A + G   +V+ LL  GA+P+V+ +
Sbjct: 409 HIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNV 468

Query: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
               P+  AA  GH ++   LLQN AKVN   K   TPL  AAR GH   VK LL   A+
Sbjct: 469 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 528

Query: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
            +       T L +A + G+ ++V  +L++  +     K G T L +A+K G   + + L
Sbjct: 529 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 588

Query: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
           L+   + N   ++G T L  AV   +++IV+ LL +         +  T L+ A ++   
Sbjct: 589 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 648

Query: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
            + R +LQ        +  G TPL  A +  + E+V LLL K A  +  +K G TPLH+ 
Sbjct: 649 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 708

Query: 376 IRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARH 427
            +     +A++L+   K G ++    + G TP ++  SH  +I    F  +H
Sbjct: 709 AQEGHVPVADVLI---KHGVMVDATTRMGYTPLHV-ASHYGNIKLVKFLLQH 756



 Score =  172 bits (437), Expect = 2e-42
 Identities = 119/377 (31%), Positives = 190/377 (50%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           ++ ++  ++ LL+    +D   E G TPL +A+  G+L IVK L++ GA+ N+ ++   T
Sbjct: 413 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 472

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L  A++ GH  + + LL+    +  +     T L  A   G T++V+LLL + ANP++ 
Sbjct: 473 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 532

Query: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
                 P+  AA  GH + V  LL+  A   C  K G TPL  AA+ G +   + LL   
Sbjct: 533 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 592

Query: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
           A  +  G N +T L VAV       VK +L R  + +    +G T L IA+K+   E+ +
Sbjct: 593 AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR 652

Query: 254 DLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKG 313
            LL  G   N     G T L  A + GH E+V  LL K A+ ++  +   T L+   ++G
Sbjct: 653 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEG 712

Query: 314 NATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLH 373
           +  +   +++     +  T+ G TPL  A+   NI++V+ LL   A V+A  K G +PLH
Sbjct: 713 HVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLH 772

Query: 374 IAIRGRSRKLAELLLRN 390
            A +     +  LLL+N
Sbjct: 773 QAAQQGHTDIVTLLLKN 789



 Score =  172 bits (435), Expect = 3e-42
 Identities = 121/376 (32%), Positives = 191/376 (50%), Gaps = 13/376 (3%)

Query: 40  TPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEH 99
           T  + AA  GNL+   + ++NG + N  + +    L  ASKEGHV +V ELL   + LE 
Sbjct: 47  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 106

Query: 100 RDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQN 159
               G TAL  A   G+ +VV  L+++GAN +        P+  AA   H ++V  LL+N
Sbjct: 107 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166

Query: 160 GAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSV 219
           GA  N + + G TPL  A ++GH   V HL+  G     +G   + AL +A +   T++ 
Sbjct: 167 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTA 222

Query: 220 KEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRG 279
             +L+ +PN ++  K G T L IA+   +  + Q LL+ G  VN   ++G T L  A R 
Sbjct: 223 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 282

Query: 280 GHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPL 339
           G+V +VR LL + A I+ + +D  T L+ A   G+  +   +L      +  TK+G +P+
Sbjct: 283 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 342

Query: 340 IKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYR 399
             A +  +++ V LLL   A++  +     TPLH+A      ++A++LL          +
Sbjct: 343 HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA------K 396

Query: 400 PNKA---GETPYNIDC 412
           PN     G TP +I C
Sbjct: 397 PNSRALNGFTPLHIAC 412



 Score =  161 bits (408), Expect = 5e-39
 Identities = 118/363 (32%), Positives = 179/363 (49%), Gaps = 6/363 (1%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           +E ++  +  LL K   ++   + G T L IAA  G  E+V+EL+  GAN N +    +T
Sbjct: 87  KEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFT 146

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L  A++E H+ +V+ LL+ G N       G+T L  A  +G  +VV  L+++G    V 
Sbjct: 147 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 206

Query: 134 GLYSVYPIIWAAGRG-HADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAM 192
                 P +  A R        +LLQN    +   K G TPL  AA   +L   + LL  
Sbjct: 207 -----LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 261

Query: 193 GADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIV 252
           GA V+    N +T L +A + G    V+ +L R   +    KD  T L  A++ GH  I 
Sbjct: 262 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 321

Query: 253 QDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEK 312
           + LLD G  +    ++G + +  A +G H++ VR LLQ  A+ID    D+ T L+ A   
Sbjct: 322 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 381

Query: 313 GNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPL 372
           G+  + + +L           +G TPL  A K  ++ V+ELLL  GA + AV + G TPL
Sbjct: 382 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 441

Query: 373 HIA 375
           H+A
Sbjct: 442 HVA 444



 Score =  161 bits (408), Expect = 5e-39
 Identities = 114/361 (31%), Positives = 174/361 (48%)

Query: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
           ++P +K LL++    +  N   +TPL +AA  G+ E+ K L++N A  N +  D+ T L 
Sbjct: 449 HLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 508

Query: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
            A++ GH ++V+ LL+   N       G T L  A  +G  + V  LL   A+ +     
Sbjct: 509 CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK 568

Query: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
              P+  AA  G   +  LLL+  A  N + K G TPL  A    +L+ VK LL  G   
Sbjct: 569 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 628

Query: 197 DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLL 256
                N  T L +A K    +  + +L+   + N     G T L +A++EGH E+V  LL
Sbjct: 629 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 688

Query: 257 DAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNAT 316
                 N+ ++SG T L    + GHV +   L++    +D   +   T L+ A   GN  
Sbjct: 689 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 748

Query: 317 MVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAI 376
           +V+ +LQ   D    TK G +PL +A +  + ++V LLL  GA  + V   G TPL IA 
Sbjct: 749 LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 808

Query: 377 R 377
           R
Sbjct: 809 R 809



 Score =  160 bits (404), Expect = 1e-38
 Identities = 124/447 (27%), Positives = 201/447 (44%), Gaps = 34/447 (7%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELI--------------- 58
           +E ++  +K LLE   + +   E G TPL +A +QG+  +V  LI               
Sbjct: 153 QENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHI 212

Query: 59  --------------KNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104
                         +N  N ++     +T L  A+   ++++ + LL  G ++      G
Sbjct: 213 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 272

Query: 105 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN 164
            T L  A  +G   +V LLL  GA         + P+  AA  GH  I  +LL +GA + 
Sbjct: 273 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 332

Query: 165 CSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILK 224
              K G +P+  AA+  HL+CV+ LL   A++D    + +T L VA   G+ +  K +L 
Sbjct: 333 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 392

Query: 225 RNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEI 284
           +    N    +G T L IA K+ H  +++ LL  G  ++    SG T L  A   GH+ I
Sbjct: 393 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 452

Query: 285 VRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATK 344
           V+ LLQ+ A  ++     +T L+ A   G+  + + +LQ         KD +TPL  A +
Sbjct: 453 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 512

Query: 345 MRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIR-GRSRKLAELLLRNPKDGRLLYRPNKA 403
           + +  +V+LLL+  A  +     G TPLHIA R G    +  LL +      +     K 
Sbjct: 513 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM----TKK 568

Query: 404 GETPYNIDCSHQKSILTQIFGARHLSP 430
           G TP ++   + K  + ++   R   P
Sbjct: 569 GFTPLHVAAKYGKVRVAELLLERDAHP 595



 Score =  159 bits (401), Expect = 3e-38
 Identities = 107/333 (32%), Positives = 168/333 (50%)

Query: 22  KALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKE 81
           K LL+    V+ + +  QTPL  AA  G+  +VK L++N AN NL      T L  A++E
Sbjct: 487 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE 546

Query: 82  GHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPI 141
           GHV  V  LL+   +       G+T L  A   G+  V ELLL   A+P+  G   + P+
Sbjct: 547 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 606

Query: 142 IWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGA 201
             A    + DIV LLL  G   +     G TPL  AA++  +E  + LL  G   + E  
Sbjct: 607 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 666

Query: 202 NSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY 261
             +T L +A + G+ + V  +L +  N NL +K G T L + ++EGH  +   L+  G  
Sbjct: 667 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 726

Query: 262 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 321
           V+   R G T L  A   G++++V+ LLQ  AD++ + +   + L+ A ++G+  +V  +
Sbjct: 727 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 786

Query: 322 LQCNPDTEICTKDGETPLIKATKMRNIEVVELL 354
           L+        + DG TPL  A ++  I V ++L
Sbjct: 787 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 59/170 (34%), Positives = 92/170 (54%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           ++  +   ++LL+     +  +  G TPL +AA++G+ E+V  L+   AN NL +    T
Sbjct: 644 KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 703

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L   ++EGHV + + L+K GV ++     G+T L  A + G   +V+ LL H A+ +  
Sbjct: 704 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 763

Query: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHL 183
                 P+  AA +GH DIV LLL+NGA  N     GTTPL  A R G++
Sbjct: 764 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 813



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 63/222 (28%), Positives = 113/222 (50%), Gaps = 7/222 (3%)

Query: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
           A++ T+ + A + G      + L+   ++N  +++G   L +ASKEGH ++V +LL    
Sbjct: 43  ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 102

Query: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320
            +    + G+T L  A   G  E+VR L+   A+++ + Q   T LY A ++ +  +V+ 
Sbjct: 103 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 162

Query: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 380
           +L+   +  + T+DG TPL  A +  +  VV  L++ G K     K     LHIA R   
Sbjct: 163 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDD 218

Query: 381 RKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQI 422
            + A +LL+N  +  +L   +K G TP +I   ++   + Q+
Sbjct: 219 TRTAAVLLQNDPNPDVL---SKTGFTPLHIAAHYENLNVAQL 257



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 44/159 (27%), Positives = 82/159 (51%), Gaps = 3/159 (1%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           +E +   +  LL K  + +  N+ G TPL + A++G++ +   LIK+G   +      +T
Sbjct: 677 QEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYT 736

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L  AS  G++ +V+ LL+   ++  +   G++ L  A  +G TD+V LLL +GA+P+  
Sbjct: 737 PLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEV 796

Query: 134 GLYSVYPIIWAAGRGH---ADIVHLLLQNGAKVNCSDKY 169
                 P+  A   G+    D++ ++    + V  SDK+
Sbjct: 797 SSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKH 835


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  196 bits (498), Expect = 2e-49
 Identities = 136/410 (33%), Positives = 204/410 (49%), Gaps = 9/410 (2%)

Query: 24  LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGH 83
           LL+   + D  ++ G TPL IAA   NL + + L+  GA+ N    +  T L  AS+ G+
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 251

Query: 84  VHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIW 143
           V +V  LL  G  +E +     T L  A   G   + E+LL HGA         + PI  
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311

Query: 144 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203
           AA   H D V LLLQ  A+++       TPL  AA  GH    K LL  GA  +    N 
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371

Query: 204 MTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN 263
            T L +A K  + + ++ +LK   +++   + G T L +AS  GH  IV++LL  G   N
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431

Query: 264 IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ 323
           + +   +T L  A R GH E+ + LLQ  A ++ + +D++T L+ A   G+  MV+ +L+
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491

Query: 324 CNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKL 383
            N +  + T  G TPL  A +  ++E V  LL+K A  + + KKG TPLH+A +    ++
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551

Query: 384 AELLLRNPKDGRLLYRPNKAGE---TPYNIDCSHQKSILTQIFGARHLSP 430
           AELLL           PN AG+   TP ++   H    + ++   R  SP
Sbjct: 552 AELLLERDA------HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595



 Score =  185 bits (469), Expect = 4e-46
 Identities = 130/395 (32%), Positives = 197/395 (49%), Gaps = 3/395 (0%)

Query: 16  ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
           EN+   + LL +   V+   + G TPL IA+ +GN+ +V+ L+  GA    +  D  T L
Sbjct: 217 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276

Query: 76  ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135
             A++ GHV I E LL  G  ++ +   G + +  A      D V LLL + A      L
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL 336

Query: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
             + P+  AA  GH  +  +LL  GAK N     G TPL  A +K H+  ++ LL  GA 
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396

Query: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
           +D    + +T L VA   G+   VK +L+R  + N+++    T L +A++ GHTE+ + L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
           L     VN   +   T L  A R GH  +V+ LL+  A+ ++      T L+ A  +G+ 
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516

Query: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
             V  +L+        TK G TPL  A K   + V ELLL++ A  +A  K G TPLH+A
Sbjct: 517 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576

Query: 376 IRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 410
           +   +  + +LLL  P+ G   + P   G TP +I
Sbjct: 577 VHHNNLDIVKLLL--PRGGS-PHSPAWNGYTPLHI 608



 Score =  182 bits (463), Expect = 2e-45
 Identities = 130/387 (33%), Positives = 192/387 (49%), Gaps = 3/387 (0%)

Query: 24  LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGH 83
           LL+    +  + + G +P+ +AA+  +L+ V+ L++  A  +   LD+ T L  A+  GH
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 350

Query: 84  VHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIW 143
             + + LL  G     R + G+T L  AC K    V+ELLL  GA+        + P+  
Sbjct: 351 HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV 410

Query: 144 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203
           A+  GH  IV  LLQ GA  N S+    TPL  AAR GH E  K+LL   A V+ +  + 
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470

Query: 204 MTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN 263
            T L  A + G+T  VK +L+ N N NL    G+T L IA++EGH E V  LL+      
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 264 IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ 323
              + G T L  A + G V +   LL++ A  +  G++  T L+ AV   N  +V+ +L 
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590

Query: 324 CNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKL 383
                     +G TPL  A K   +EV   LL  G   +A   +G TPLH+A +    ++
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650

Query: 384 AELLLRNPKDGRLLYRPNKAGETPYNI 410
             LLL    +G L    NK+G TP ++
Sbjct: 651 VALLLSKQANGNL---GNKSGLTPLHL 674



 Score =  178 bits (451), Expect = 5e-44
 Identities = 126/412 (30%), Positives = 206/412 (50%), Gaps = 4/412 (0%)

Query: 16  ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
           +++  ++ LL+   ++D+      TPL +AA  G+  + K L+  GA  N   L+ +T L
Sbjct: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 375

Query: 76  ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135
             A K+ HV ++E LLK G +++     G T L  A + G   +V+ LL  GA+P+V+ +
Sbjct: 376 HIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNV 435

Query: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
               P+  AA  GH ++   LLQN AKVN   K   TPL  AAR GH   VK LL   A+
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495

Query: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
            +       T L +A + G+ ++V  +L++  +     K G T L +A+K G   + + L
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555

Query: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
           L+   + N   ++G T L  AV   +++IV+ LL +         +  T L+ A ++   
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
            + R +LQ        +  G TPL  A +  + E+V LLL K A  +  +K G TPLH+ 
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 376 IRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARH 427
            +     +A++L+   K G ++    + G TP ++  SH  +I    F  +H
Sbjct: 676 AQEGHVPVADVLI---KHGVMVDATTRMGYTPLHV-ASHYGNIKLVKFLLQH 723



 Score =  172 bits (437), Expect = 2e-42
 Identities = 119/377 (31%), Positives = 190/377 (50%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           ++ ++  ++ LL+    +D   E G TPL +A+  G+L IVK L++ GA+ N+ ++   T
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L  A++ GH  + + LL+    +  +     T L  A   G T++V+LLL + ANP++ 
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499

Query: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
                 P+  AA  GH + V  LL+  A   C  K G TPL  AA+ G +   + LL   
Sbjct: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559

Query: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
           A  +  G N +T L VAV       VK +L R  + +    +G T L IA+K+   E+ +
Sbjct: 560 AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR 619

Query: 254 DLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKG 313
            LL  G   N     G T L  A + GH E+V  LL K A+ ++  +   T L+   ++G
Sbjct: 620 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEG 679

Query: 314 NATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLH 373
           +  +   +++     +  T+ G TPL  A+   NI++V+ LL   A V+A  K G +PLH
Sbjct: 680 HVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLH 739

Query: 374 IAIRGRSRKLAELLLRN 390
            A +     +  LLL+N
Sbjct: 740 QAAQQGHTDIVTLLLKN 756



 Score =  172 bits (435), Expect = 3e-42
 Identities = 121/376 (32%), Positives = 191/376 (50%), Gaps = 13/376 (3%)

Query: 40  TPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEH 99
           T  + AA  GNL+   + ++NG + N  + +    L  ASKEGHV +V ELL   + LE 
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 100 RDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQN 159
               G TAL  A   G+ +VV  L+++GAN +        P+  AA   H ++V  LL+N
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133

Query: 160 GAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSV 219
           GA  N + + G TPL  A ++GH   V HL+  G     +G   + AL +A +   T++ 
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTA 189

Query: 220 KEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRG 279
             +L+ +PN ++  K G T L IA+   +  + Q LL+ G  VN   ++G T L  A R 
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249

Query: 280 GHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPL 339
           G+V +VR LL + A I+ + +D  T L+ A   G+  +   +L      +  TK+G +P+
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309

Query: 340 IKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYR 399
             A +  +++ V LLL   A++  +     TPLH+A      ++A++LL          +
Sbjct: 310 HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA------K 363

Query: 400 PNKA---GETPYNIDC 412
           PN     G TP +I C
Sbjct: 364 PNSRALNGFTPLHIAC 379



 Score =  161 bits (408), Expect = 5e-39
 Identities = 118/363 (32%), Positives = 179/363 (49%), Gaps = 6/363 (1%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           +E ++  +  LL K   ++   + G T L IAA  G  E+V+EL+  GAN N +    +T
Sbjct: 54  KEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFT 113

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L  A++E H+ +V+ LL+ G N       G+T L  A  +G  +VV  L+++G    V 
Sbjct: 114 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173

Query: 134 GLYSVYPIIWAAGRG-HADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAM 192
                 P +  A R        +LLQN    +   K G TPL  AA   +L   + LL  
Sbjct: 174 -----LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228

Query: 193 GADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIV 252
           GA V+    N +T L +A + G    V+ +L R   +    KD  T L  A++ GH  I 
Sbjct: 229 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288

Query: 253 QDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEK 312
           + LLD G  +    ++G + +  A +G H++ VR LLQ  A+ID    D+ T L+ A   
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348

Query: 313 GNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPL 372
           G+  + + +L           +G TPL  A K  ++ V+ELLL  GA + AV + G TPL
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408

Query: 373 HIA 375
           H+A
Sbjct: 409 HVA 411



 Score =  161 bits (408), Expect = 5e-39
 Identities = 114/361 (31%), Positives = 174/361 (48%)

Query: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
           ++P +K LL++    +  N   +TPL +AA  G+ E+ K L++N A  N +  D+ T L 
Sbjct: 416 HLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 475

Query: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
            A++ GH ++V+ LL+   N       G T L  A  +G  + V  LL   A+ +     
Sbjct: 476 CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK 535

Query: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
              P+  AA  G   +  LLL+  A  N + K G TPL  A    +L+ VK LL  G   
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595

Query: 197 DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLL 256
                N  T L +A K    +  + +L+   + N     G T L +A++EGH E+V  LL
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655

Query: 257 DAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNAT 316
                 N+ ++SG T L    + GHV +   L++    +D   +   T L+ A   GN  
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715

Query: 317 MVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAI 376
           +V+ +LQ   D    TK G +PL +A +  + ++V LLL  GA  + V   G TPL IA 
Sbjct: 716 LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775

Query: 377 R 377
           R
Sbjct: 776 R 776



 Score =  160 bits (404), Expect = 1e-38
 Identities = 124/447 (27%), Positives = 201/447 (44%), Gaps = 34/447 (7%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELI--------------- 58
           +E ++  +K LLE   + +   E G TPL +A +QG+  +V  LI               
Sbjct: 120 QENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHI 179

Query: 59  --------------KNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104
                         +N  N ++     +T L  A+   ++++ + LL  G ++      G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 105 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN 164
            T L  A  +G   +V LLL  GA         + P+  AA  GH  I  +LL +GA + 
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299

Query: 165 CSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILK 224
              K G +P+  AA+  HL+CV+ LL   A++D    + +T L VA   G+ +  K +L 
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359

Query: 225 RNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEI 284
           +    N    +G T L IA K+ H  +++ LL  G  ++    SG T L  A   GH+ I
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 285 VRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATK 344
           V+ LLQ+ A  ++     +T L+ A   G+  + + +LQ         KD +TPL  A +
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 345 MRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIR-GRSRKLAELLLRNPKDGRLLYRPNKA 403
           + +  +V+LLL+  A  +     G TPLHIA R G    +  LL +      +     K 
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM----TKK 535

Query: 404 GETPYNIDCSHQKSILTQIFGARHLSP 430
           G TP ++   + K  + ++   R   P
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAHP 562



 Score =  159 bits (401), Expect = 3e-38
 Identities = 107/333 (32%), Positives = 168/333 (50%)

Query: 22  KALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKE 81
           K LL+    V+ + +  QTPL  AA  G+  +VK L++N AN NL      T L  A++E
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE 513

Query: 82  GHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPI 141
           GHV  V  LL+   +       G+T L  A   G+  V ELLL   A+P+  G   + P+
Sbjct: 514 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573

Query: 142 IWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGA 201
             A    + DIV LLL  G   +     G TPL  AA++  +E  + LL  G   + E  
Sbjct: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633

Query: 202 NSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY 261
             +T L +A + G+ + V  +L +  N NL +K G T L + ++EGH  +   L+  G  
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693

Query: 262 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 321
           V+   R G T L  A   G++++V+ LLQ  AD++ + +   + L+ A ++G+  +V  +
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753

Query: 322 LQCNPDTEICTKDGETPLIKATKMRNIEVVELL 354
           L+        + DG TPL  A ++  I V ++L
Sbjct: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  114 bits (284), Expect = 1e-24
 Identities = 88/319 (27%), Positives = 144/319 (45%), Gaps = 29/319 (9%)

Query: 100 RDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQN 159
           R+    T+ + A   G  D     L +G + +      +  +  A+  GH  +V  LL  
Sbjct: 8   READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67

Query: 160 GAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSV 219
              +  + K G T L  AA  G  E V+ L+  GA+V+ +     T L +A +  + + V
Sbjct: 68  EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127

Query: 220 KEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT--YVNIP------------ 265
           K +L+   N N+  +DG T L +A ++GH  +V  L++ GT   V +P            
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187

Query: 266 ---------------DRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAV 310
                           ++G T L  A    ++ + + LL + A ++   Q+  T L+ A 
Sbjct: 188 TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247

Query: 311 EKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDT 370
            +GN  MVR +L      E  TKD  TPL  A +  ++ + E+LLD GA + A  K G +
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307

Query: 371 PLHIAIRGRSRKLAELLLR 389
           P+H+A +G       LLL+
Sbjct: 308 PIHMAAQGDHLDCVRLLLQ 326



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 59/170 (34%), Positives = 92/170 (54%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           ++  +   ++LL+     +  +  G TPL +AA++G+ E+V  L+   AN NL +    T
Sbjct: 611 KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 670

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L   ++EGHV + + L+K GV ++     G+T L  A + G   +V+ LL H A+ +  
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730

Query: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHL 183
                 P+  AA +GH DIV LLL+NGA  N     GTTPL  A R G++
Sbjct: 731 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 63/222 (28%), Positives = 113/222 (50%), Gaps = 7/222 (3%)

Query: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
           A++ T+ + A + G      + L+   ++N  +++G   L +ASKEGH ++V +LL    
Sbjct: 10  ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 69

Query: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320
            +    + G+T L  A   G  E+VR L+   A+++ + Q   T LY A ++ +  +V+ 
Sbjct: 70  ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129

Query: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 380
           +L+   +  + T+DG TPL  A +  +  VV  L++ G K     K     LHIA R   
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDD 185

Query: 381 RKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQI 422
            + A +LL+N  +  +L   +K G TP +I   ++   + Q+
Sbjct: 186 TRTAAVLLQNDPNPDVL---SKTGFTPLHIAAHYENLNVAQL 224



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 50/189 (26%), Positives = 91/189 (48%), Gaps = 12/189 (6%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           +E +   +  LL K  + +  N+ G TPL + A++G++ +   LIK+G   +      +T
Sbjct: 644 QEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYT 703

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L  AS  G++ +V+ LL+   ++  +   G++ L  A  +G TD+V LLL +GA+P+  
Sbjct: 704 PLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEV 763

Query: 134 GLYSVYPIIWAAGRGH---ADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLL 190
                 P+  A   G+    D++ ++    + V  SDK+         R    E V  +L
Sbjct: 764 SSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKH---------RMSFPETVDEIL 814

Query: 191 AMGADVDQE 199
            +  D  +E
Sbjct: 815 DVSEDEGEE 823



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 39/129 (30%), Positives = 63/129 (48%)

Query: 262 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 321
           V   +    T  + A R G+++     L+   DI+   Q+    L+ A ++G+  MV ++
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 322 LQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSR 381
           L      E  TK G T L  A      EVV  L++ GA V+A  +KG TPL++A +    
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 382 KLAELLLRN 390
           ++ + LL N
Sbjct: 125 EVVKFLLEN 133


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  196 bits (498), Expect = 2e-49
 Identities = 136/410 (33%), Positives = 204/410 (49%), Gaps = 9/410 (2%)

Query: 24  LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGH 83
           LL+   + D  ++ G TPL IAA   NL + + L+  GA+ N    +  T L  AS+ G+
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 251

Query: 84  VHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIW 143
           V +V  LL  G  +E +     T L  A   G   + E+LL HGA         + PI  
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311

Query: 144 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203
           AA   H D V LLLQ  A+++       TPL  AA  GH    K LL  GA  +    N 
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371

Query: 204 MTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN 263
            T L +A K  + + ++ +LK   +++   + G T L +AS  GH  IV++LL  G   N
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431

Query: 264 IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ 323
           + +   +T L  A R GH E+ + LLQ  A ++ + +D++T L+ A   G+  MV+ +L+
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491

Query: 324 CNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKL 383
            N +  + T  G TPL  A +  ++E V  LL+K A  + + KKG TPLH+A +    ++
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551

Query: 384 AELLLRNPKDGRLLYRPNKAGE---TPYNIDCSHQKSILTQIFGARHLSP 430
           AELLL           PN AG+   TP ++   H    + ++   R  SP
Sbjct: 552 AELLLERDA------HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595



 Score =  185 bits (469), Expect = 4e-46
 Identities = 130/395 (32%), Positives = 197/395 (49%), Gaps = 3/395 (0%)

Query: 16  ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
           EN+   + LL +   V+   + G TPL IA+ +GN+ +V+ L+  GA    +  D  T L
Sbjct: 217 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276

Query: 76  ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135
             A++ GHV I E LL  G  ++ +   G + +  A      D V LLL + A      L
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL 336

Query: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
             + P+  AA  GH  +  +LL  GAK N     G TPL  A +K H+  ++ LL  GA 
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396

Query: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
           +D    + +T L VA   G+   VK +L+R  + N+++    T L +A++ GHTE+ + L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
           L     VN   +   T L  A R GH  +V+ LL+  A+ ++      T L+ A  +G+ 
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516

Query: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
             V  +L+        TK G TPL  A K   + V ELLL++ A  +A  K G TPLH+A
Sbjct: 517 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576

Query: 376 IRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 410
           +   +  + +LLL  P+ G   + P   G TP +I
Sbjct: 577 VHHNNLDIVKLLL--PRGGS-PHSPAWNGYTPLHI 608



 Score =  182 bits (463), Expect = 2e-45
 Identities = 130/387 (33%), Positives = 192/387 (49%), Gaps = 3/387 (0%)

Query: 24  LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGH 83
           LL+    +  + + G +P+ +AA+  +L+ V+ L++  A  +   LD+ T L  A+  GH
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 350

Query: 84  VHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIW 143
             + + LL  G     R + G+T L  AC K    V+ELLL  GA+        + P+  
Sbjct: 351 HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV 410

Query: 144 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203
           A+  GH  IV  LLQ GA  N S+    TPL  AAR GH E  K+LL   A V+ +  + 
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470

Query: 204 MTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN 263
            T L  A + G+T  VK +L+ N N NL    G+T L IA++EGH E V  LL+      
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 264 IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ 323
              + G T L  A + G V +   LL++ A  +  G++  T L+ AV   N  +V+ +L 
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590

Query: 324 CNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKL 383
                     +G TPL  A K   +EV   LL  G   +A   +G TPLH+A +    ++
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650

Query: 384 AELLLRNPKDGRLLYRPNKAGETPYNI 410
             LLL    +G L    NK+G TP ++
Sbjct: 651 VALLLSKQANGNL---GNKSGLTPLHL 674



 Score =  178 bits (451), Expect = 5e-44
 Identities = 126/412 (30%), Positives = 206/412 (50%), Gaps = 4/412 (0%)

Query: 16  ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
           +++  ++ LL+   ++D+      TPL +AA  G+  + K L+  GA  N   L+ +T L
Sbjct: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 375

Query: 76  ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135
             A K+ HV ++E LLK G +++     G T L  A + G   +V+ LL  GA+P+V+ +
Sbjct: 376 HIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNV 435

Query: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
               P+  AA  GH ++   LLQN AKVN   K   TPL  AAR GH   VK LL   A+
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495

Query: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
            +       T L +A + G+ ++V  +L++  +     K G T L +A+K G   + + L
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555

Query: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
           L+   + N   ++G T L  AV   +++IV+ LL +         +  T L+ A ++   
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
            + R +LQ        +  G TPL  A +  + E+V LLL K A  +  +K G TPLH+ 
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 376 IRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARH 427
            +     +A++L+   K G ++    + G TP ++  SH  +I    F  +H
Sbjct: 676 AQEGHVPVADVLI---KHGVMVDATTRMGYTPLHV-ASHYGNIKLVKFLLQH 723



 Score =  172 bits (437), Expect = 2e-42
 Identities = 119/377 (31%), Positives = 190/377 (50%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           ++ ++  ++ LL+    +D   E G TPL +A+  G+L IVK L++ GA+ N+ ++   T
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L  A++ GH  + + LL+    +  +     T L  A   G T++V+LLL + ANP++ 
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499

Query: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
                 P+  AA  GH + V  LL+  A   C  K G TPL  AA+ G +   + LL   
Sbjct: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559

Query: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
           A  +  G N +T L VAV       VK +L R  + +    +G T L IA+K+   E+ +
Sbjct: 560 AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR 619

Query: 254 DLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKG 313
            LL  G   N     G T L  A + GH E+V  LL K A+ ++  +   T L+   ++G
Sbjct: 620 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEG 679

Query: 314 NATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLH 373
           +  +   +++     +  T+ G TPL  A+   NI++V+ LL   A V+A  K G +PLH
Sbjct: 680 HVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLH 739

Query: 374 IAIRGRSRKLAELLLRN 390
            A +     +  LLL+N
Sbjct: 740 QAAQQGHTDIVTLLLKN 756



 Score =  172 bits (435), Expect = 3e-42
 Identities = 121/376 (32%), Positives = 191/376 (50%), Gaps = 13/376 (3%)

Query: 40  TPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEH 99
           T  + AA  GNL+   + ++NG + N  + +    L  ASKEGHV +V ELL   + LE 
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 100 RDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQN 159
               G TAL  A   G+ +VV  L+++GAN +        P+  AA   H ++V  LL+N
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133

Query: 160 GAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSV 219
           GA  N + + G TPL  A ++GH   V HL+  G     +G   + AL +A +   T++ 
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTA 189

Query: 220 KEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRG 279
             +L+ +PN ++  K G T L IA+   +  + Q LL+ G  VN   ++G T L  A R 
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249

Query: 280 GHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPL 339
           G+V +VR LL + A I+ + +D  T L+ A   G+  +   +L      +  TK+G +P+
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309

Query: 340 IKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYR 399
             A +  +++ V LLL   A++  +     TPLH+A      ++A++LL          +
Sbjct: 310 HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA------K 363

Query: 400 PNKA---GETPYNIDC 412
           PN     G TP +I C
Sbjct: 364 PNSRALNGFTPLHIAC 379



 Score =  161 bits (408), Expect = 5e-39
 Identities = 118/363 (32%), Positives = 179/363 (49%), Gaps = 6/363 (1%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           +E ++  +  LL K   ++   + G T L IAA  G  E+V+EL+  GAN N +    +T
Sbjct: 54  KEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFT 113

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L  A++E H+ +V+ LL+ G N       G+T L  A  +G  +VV  L+++G    V 
Sbjct: 114 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173

Query: 134 GLYSVYPIIWAAGRG-HADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAM 192
                 P +  A R        +LLQN    +   K G TPL  AA   +L   + LL  
Sbjct: 174 -----LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228

Query: 193 GADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIV 252
           GA V+    N +T L +A + G    V+ +L R   +    KD  T L  A++ GH  I 
Sbjct: 229 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288

Query: 253 QDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEK 312
           + LLD G  +    ++G + +  A +G H++ VR LLQ  A+ID    D+ T L+ A   
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348

Query: 313 GNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPL 372
           G+  + + +L           +G TPL  A K  ++ V+ELLL  GA + AV + G TPL
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408

Query: 373 HIA 375
           H+A
Sbjct: 409 HVA 411



 Score =  161 bits (408), Expect = 5e-39
 Identities = 114/361 (31%), Positives = 174/361 (48%)

Query: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
           ++P +K LL++    +  N   +TPL +AA  G+ E+ K L++N A  N +  D+ T L 
Sbjct: 416 HLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 475

Query: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
            A++ GH ++V+ LL+   N       G T L  A  +G  + V  LL   A+ +     
Sbjct: 476 CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK 535

Query: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
              P+  AA  G   +  LLL+  A  N + K G TPL  A    +L+ VK LL  G   
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595

Query: 197 DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLL 256
                N  T L +A K    +  + +L+   + N     G T L +A++EGH E+V  LL
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655

Query: 257 DAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNAT 316
                 N+ ++SG T L    + GHV +   L++    +D   +   T L+ A   GN  
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715

Query: 317 MVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAI 376
           +V+ +LQ   D    TK G +PL +A +  + ++V LLL  GA  + V   G TPL IA 
Sbjct: 716 LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775

Query: 377 R 377
           R
Sbjct: 776 R 776



 Score =  160 bits (404), Expect = 1e-38
 Identities = 124/447 (27%), Positives = 201/447 (44%), Gaps = 34/447 (7%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELI--------------- 58
           +E ++  +K LLE   + +   E G TPL +A +QG+  +V  LI               
Sbjct: 120 QENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHI 179

Query: 59  --------------KNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104
                         +N  N ++     +T L  A+   ++++ + LL  G ++      G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 105 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN 164
            T L  A  +G   +V LLL  GA         + P+  AA  GH  I  +LL +GA + 
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299

Query: 165 CSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILK 224
              K G +P+  AA+  HL+CV+ LL   A++D    + +T L VA   G+ +  K +L 
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359

Query: 225 RNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEI 284
           +    N    +G T L IA K+ H  +++ LL  G  ++    SG T L  A   GH+ I
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 285 VRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATK 344
           V+ LLQ+ A  ++     +T L+ A   G+  + + +LQ         KD +TPL  A +
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 345 MRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIR-GRSRKLAELLLRNPKDGRLLYRPNKA 403
           + +  +V+LLL+  A  +     G TPLHIA R G    +  LL +      +     K 
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM----TKK 535

Query: 404 GETPYNIDCSHQKSILTQIFGARHLSP 430
           G TP ++   + K  + ++   R   P
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAHP 562



 Score =  159 bits (401), Expect = 3e-38
 Identities = 107/333 (32%), Positives = 168/333 (50%)

Query: 22  KALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKE 81
           K LL+    V+ + +  QTPL  AA  G+  +VK L++N AN NL      T L  A++E
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE 513

Query: 82  GHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPI 141
           GHV  V  LL+   +       G+T L  A   G+  V ELLL   A+P+  G   + P+
Sbjct: 514 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573

Query: 142 IWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGA 201
             A    + DIV LLL  G   +     G TPL  AA++  +E  + LL  G   + E  
Sbjct: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633

Query: 202 NSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY 261
             +T L +A + G+ + V  +L +  N NL +K G T L + ++EGH  +   L+  G  
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693

Query: 262 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 321
           V+   R G T L  A   G++++V+ LLQ  AD++ + +   + L+ A ++G+  +V  +
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753

Query: 322 LQCNPDTEICTKDGETPLIKATKMRNIEVVELL 354
           L+        + DG TPL  A ++  I V ++L
Sbjct: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  114 bits (284), Expect = 1e-24
 Identities = 88/319 (27%), Positives = 144/319 (45%), Gaps = 29/319 (9%)

Query: 100 RDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQN 159
           R+    T+ + A   G  D     L +G + +      +  +  A+  GH  +V  LL  
Sbjct: 8   READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67

Query: 160 GAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSV 219
              +  + K G T L  AA  G  E V+ L+  GA+V+ +     T L +A +  + + V
Sbjct: 68  EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127

Query: 220 KEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT--YVNIP------------ 265
           K +L+   N N+  +DG T L +A ++GH  +V  L++ GT   V +P            
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187

Query: 266 ---------------DRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAV 310
                           ++G T L  A    ++ + + LL + A ++   Q+  T L+ A 
Sbjct: 188 TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247

Query: 311 EKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDT 370
            +GN  MVR +L      E  TKD  TPL  A +  ++ + E+LLD GA + A  K G +
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307

Query: 371 PLHIAIRGRSRKLAELLLR 389
           P+H+A +G       LLL+
Sbjct: 308 PIHMAAQGDHLDCVRLLLQ 326



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 59/170 (34%), Positives = 92/170 (54%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           ++  +   ++LL+     +  +  G TPL +AA++G+ E+V  L+   AN NL +    T
Sbjct: 611 KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 670

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L   ++EGHV + + L+K GV ++     G+T L  A + G   +V+ LL H A+ +  
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730

Query: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHL 183
                 P+  AA +GH DIV LLL+NGA  N     GTTPL  A R G++
Sbjct: 731 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 63/222 (28%), Positives = 113/222 (50%), Gaps = 7/222 (3%)

Query: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
           A++ T+ + A + G      + L+   ++N  +++G   L +ASKEGH ++V +LL    
Sbjct: 10  ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 69

Query: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320
            +    + G+T L  A   G  E+VR L+   A+++ + Q   T LY A ++ +  +V+ 
Sbjct: 70  ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129

Query: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 380
           +L+   +  + T+DG TPL  A +  +  VV  L++ G K     K     LHIA R   
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDD 185

Query: 381 RKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQI 422
            + A +LL+N  +  +L   +K G TP +I   ++   + Q+
Sbjct: 186 TRTAAVLLQNDPNPDVL---SKTGFTPLHIAAHYENLNVAQL 224



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 50/189 (26%), Positives = 91/189 (48%), Gaps = 12/189 (6%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           +E +   +  LL K  + +  N+ G TPL + A++G++ +   LIK+G   +      +T
Sbjct: 644 QEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYT 703

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L  AS  G++ +V+ LL+   ++  +   G++ L  A  +G TD+V LLL +GA+P+  
Sbjct: 704 PLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEV 763

Query: 134 GLYSVYPIIWAAGRGH---ADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLL 190
                 P+  A   G+    D++ ++    + V  SDK+         R    E V  +L
Sbjct: 764 SSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKH---------RMSFPETVDEIL 814

Query: 191 AMGADVDQE 199
            +  D  +E
Sbjct: 815 DVSEDEGEE 823



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 39/129 (30%), Positives = 63/129 (48%)

Query: 262 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 321
           V   +    T  + A R G+++     L+   DI+   Q+    L+ A ++G+  MV ++
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 322 LQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSR 381
           L      E  TK G T L  A      EVV  L++ GA V+A  +KG TPL++A +    
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 382 KLAELLLRN 390
           ++ + LL N
Sbjct: 125 EVVKFLLEN 133


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  196 bits (498), Expect = 2e-49
 Identities = 136/410 (33%), Positives = 204/410 (49%), Gaps = 9/410 (2%)

Query: 24  LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGH 83
           LL+   + D  ++ G TPL IAA   NL + + L+  GA+ N    +  T L  AS+ G+
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 251

Query: 84  VHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIW 143
           V +V  LL  G  +E +     T L  A   G   + E+LL HGA         + PI  
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311

Query: 144 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203
           AA   H D V LLLQ  A+++       TPL  AA  GH    K LL  GA  +    N 
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371

Query: 204 MTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN 263
            T L +A K  + + ++ +LK   +++   + G T L +AS  GH  IV++LL  G   N
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431

Query: 264 IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ 323
           + +   +T L  A R GH E+ + LLQ  A ++ + +D++T L+ A   G+  MV+ +L+
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491

Query: 324 CNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKL 383
            N +  + T  G TPL  A +  ++E V  LL+K A  + + KKG TPLH+A +    ++
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551

Query: 384 AELLLRNPKDGRLLYRPNKAGE---TPYNIDCSHQKSILTQIFGARHLSP 430
           AELLL           PN AG+   TP ++   H    + ++   R  SP
Sbjct: 552 AELLLERDA------HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595



 Score =  185 bits (469), Expect = 4e-46
 Identities = 130/395 (32%), Positives = 197/395 (49%), Gaps = 3/395 (0%)

Query: 16  ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
           EN+   + LL +   V+   + G TPL IA+ +GN+ +V+ L+  GA    +  D  T L
Sbjct: 217 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276

Query: 76  ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135
             A++ GHV I E LL  G  ++ +   G + +  A      D V LLL + A      L
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL 336

Query: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
             + P+  AA  GH  +  +LL  GAK N     G TPL  A +K H+  ++ LL  GA 
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396

Query: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
           +D    + +T L VA   G+   VK +L+R  + N+++    T L +A++ GHTE+ + L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
           L     VN   +   T L  A R GH  +V+ LL+  A+ ++      T L+ A  +G+ 
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516

Query: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
             V  +L+        TK G TPL  A K   + V ELLL++ A  +A  K G TPLH+A
Sbjct: 517 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576

Query: 376 IRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 410
           +   +  + +LLL  P+ G   + P   G TP +I
Sbjct: 577 VHHNNLDIVKLLL--PRGGS-PHSPAWNGYTPLHI 608



 Score =  182 bits (463), Expect = 2e-45
 Identities = 130/387 (33%), Positives = 192/387 (49%), Gaps = 3/387 (0%)

Query: 24  LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGH 83
           LL+    +  + + G +P+ +AA+  +L+ V+ L++  A  +   LD+ T L  A+  GH
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 350

Query: 84  VHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIW 143
             + + LL  G     R + G+T L  AC K    V+ELLL  GA+        + P+  
Sbjct: 351 HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV 410

Query: 144 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203
           A+  GH  IV  LLQ GA  N S+    TPL  AAR GH E  K+LL   A V+ +  + 
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470

Query: 204 MTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN 263
            T L  A + G+T  VK +L+ N N NL    G+T L IA++EGH E V  LL+      
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 264 IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ 323
              + G T L  A + G V +   LL++ A  +  G++  T L+ AV   N  +V+ +L 
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590

Query: 324 CNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKL 383
                     +G TPL  A K   +EV   LL  G   +A   +G TPLH+A +    ++
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650

Query: 384 AELLLRNPKDGRLLYRPNKAGETPYNI 410
             LLL    +G L    NK+G TP ++
Sbjct: 651 VALLLSKQANGNL---GNKSGLTPLHL 674



 Score =  178 bits (451), Expect = 5e-44
 Identities = 126/412 (30%), Positives = 206/412 (50%), Gaps = 4/412 (0%)

Query: 16  ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
           +++  ++ LL+   ++D+      TPL +AA  G+  + K L+  GA  N   L+ +T L
Sbjct: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 375

Query: 76  ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135
             A K+ HV ++E LLK G +++     G T L  A + G   +V+ LL  GA+P+V+ +
Sbjct: 376 HIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNV 435

Query: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
               P+  AA  GH ++   LLQN AKVN   K   TPL  AAR GH   VK LL   A+
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495

Query: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
            +       T L +A + G+ ++V  +L++  +     K G T L +A+K G   + + L
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555

Query: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
           L+   + N   ++G T L  AV   +++IV+ LL +         +  T L+ A ++   
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
            + R +LQ        +  G TPL  A +  + E+V LLL K A  +  +K G TPLH+ 
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 376 IRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARH 427
            +     +A++L+   K G ++    + G TP ++  SH  +I    F  +H
Sbjct: 676 AQEGHVPVADVLI---KHGVMVDATTRMGYTPLHV-ASHYGNIKLVKFLLQH 723



 Score =  172 bits (437), Expect = 2e-42
 Identities = 119/377 (31%), Positives = 190/377 (50%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           ++ ++  ++ LL+    +D   E G TPL +A+  G+L IVK L++ GA+ N+ ++   T
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L  A++ GH  + + LL+    +  +     T L  A   G T++V+LLL + ANP++ 
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499

Query: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
                 P+  AA  GH + V  LL+  A   C  K G TPL  AA+ G +   + LL   
Sbjct: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559

Query: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
           A  +  G N +T L VAV       VK +L R  + +    +G T L IA+K+   E+ +
Sbjct: 560 AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR 619

Query: 254 DLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKG 313
            LL  G   N     G T L  A + GH E+V  LL K A+ ++  +   T L+   ++G
Sbjct: 620 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEG 679

Query: 314 NATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLH 373
           +  +   +++     +  T+ G TPL  A+   NI++V+ LL   A V+A  K G +PLH
Sbjct: 680 HVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLH 739

Query: 374 IAIRGRSRKLAELLLRN 390
            A +     +  LLL+N
Sbjct: 740 QAAQQGHTDIVTLLLKN 756



 Score =  172 bits (435), Expect = 3e-42
 Identities = 121/376 (32%), Positives = 191/376 (50%), Gaps = 13/376 (3%)

Query: 40  TPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEH 99
           T  + AA  GNL+   + ++NG + N  + +    L  ASKEGHV +V ELL   + LE 
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 100 RDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQN 159
               G TAL  A   G+ +VV  L+++GAN +        P+  AA   H ++V  LL+N
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133

Query: 160 GAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSV 219
           GA  N + + G TPL  A ++GH   V HL+  G     +G   + AL +A +   T++ 
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTA 189

Query: 220 KEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRG 279
             +L+ +PN ++  K G T L IA+   +  + Q LL+ G  VN   ++G T L  A R 
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249

Query: 280 GHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPL 339
           G+V +VR LL + A I+ + +D  T L+ A   G+  +   +L      +  TK+G +P+
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309

Query: 340 IKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYR 399
             A +  +++ V LLL   A++  +     TPLH+A      ++A++LL          +
Sbjct: 310 HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA------K 363

Query: 400 PNKA---GETPYNIDC 412
           PN     G TP +I C
Sbjct: 364 PNSRALNGFTPLHIAC 379



 Score =  161 bits (408), Expect = 5e-39
 Identities = 118/363 (32%), Positives = 179/363 (49%), Gaps = 6/363 (1%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           +E ++  +  LL K   ++   + G T L IAA  G  E+V+EL+  GAN N +    +T
Sbjct: 54  KEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFT 113

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L  A++E H+ +V+ LL+ G N       G+T L  A  +G  +VV  L+++G    V 
Sbjct: 114 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173

Query: 134 GLYSVYPIIWAAGRG-HADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAM 192
                 P +  A R        +LLQN    +   K G TPL  AA   +L   + LL  
Sbjct: 174 -----LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228

Query: 193 GADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIV 252
           GA V+    N +T L +A + G    V+ +L R   +    KD  T L  A++ GH  I 
Sbjct: 229 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288

Query: 253 QDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEK 312
           + LLD G  +    ++G + +  A +G H++ VR LLQ  A+ID    D+ T L+ A   
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348

Query: 313 GNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPL 372
           G+  + + +L           +G TPL  A K  ++ V+ELLL  GA + AV + G TPL
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408

Query: 373 HIA 375
           H+A
Sbjct: 409 HVA 411



 Score =  161 bits (408), Expect = 5e-39
 Identities = 114/361 (31%), Positives = 174/361 (48%)

Query: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
           ++P +K LL++    +  N   +TPL +AA  G+ E+ K L++N A  N +  D+ T L 
Sbjct: 416 HLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 475

Query: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
            A++ GH ++V+ LL+   N       G T L  A  +G  + V  LL   A+ +     
Sbjct: 476 CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK 535

Query: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
              P+  AA  G   +  LLL+  A  N + K G TPL  A    +L+ VK LL  G   
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595

Query: 197 DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLL 256
                N  T L +A K    +  + +L+   + N     G T L +A++EGH E+V  LL
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655

Query: 257 DAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNAT 316
                 N+ ++SG T L    + GHV +   L++    +D   +   T L+ A   GN  
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715

Query: 317 MVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAI 376
           +V+ +LQ   D    TK G +PL +A +  + ++V LLL  GA  + V   G TPL IA 
Sbjct: 716 LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775

Query: 377 R 377
           R
Sbjct: 776 R 776



 Score =  160 bits (404), Expect = 1e-38
 Identities = 124/447 (27%), Positives = 201/447 (44%), Gaps = 34/447 (7%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELI--------------- 58
           +E ++  +K LLE   + +   E G TPL +A +QG+  +V  LI               
Sbjct: 120 QENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHI 179

Query: 59  --------------KNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104
                         +N  N ++     +T L  A+   ++++ + LL  G ++      G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 105 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN 164
            T L  A  +G   +V LLL  GA         + P+  AA  GH  I  +LL +GA + 
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299

Query: 165 CSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILK 224
              K G +P+  AA+  HL+CV+ LL   A++D    + +T L VA   G+ +  K +L 
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359

Query: 225 RNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEI 284
           +    N    +G T L IA K+ H  +++ LL  G  ++    SG T L  A   GH+ I
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 285 VRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATK 344
           V+ LLQ+ A  ++     +T L+ A   G+  + + +LQ         KD +TPL  A +
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 345 MRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIR-GRSRKLAELLLRNPKDGRLLYRPNKA 403
           + +  +V+LLL+  A  +     G TPLHIA R G    +  LL +      +     K 
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM----TKK 535

Query: 404 GETPYNIDCSHQKSILTQIFGARHLSP 430
           G TP ++   + K  + ++   R   P
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAHP 562



 Score =  159 bits (401), Expect = 3e-38
 Identities = 107/333 (32%), Positives = 168/333 (50%)

Query: 22  KALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKE 81
           K LL+    V+ + +  QTPL  AA  G+  +VK L++N AN NL      T L  A++E
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE 513

Query: 82  GHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPI 141
           GHV  V  LL+   +       G+T L  A   G+  V ELLL   A+P+  G   + P+
Sbjct: 514 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573

Query: 142 IWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGA 201
             A    + DIV LLL  G   +     G TPL  AA++  +E  + LL  G   + E  
Sbjct: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633

Query: 202 NSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY 261
             +T L +A + G+ + V  +L +  N NL +K G T L + ++EGH  +   L+  G  
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693

Query: 262 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 321
           V+   R G T L  A   G++++V+ LLQ  AD++ + +   + L+ A ++G+  +V  +
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753

Query: 322 LQCNPDTEICTKDGETPLIKATKMRNIEVVELL 354
           L+        + DG TPL  A ++  I V ++L
Sbjct: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  114 bits (284), Expect = 1e-24
 Identities = 88/319 (27%), Positives = 144/319 (45%), Gaps = 29/319 (9%)

Query: 100 RDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQN 159
           R+    T+ + A   G  D     L +G + +      +  +  A+  GH  +V  LL  
Sbjct: 8   READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67

Query: 160 GAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSV 219
              +  + K G T L  AA  G  E V+ L+  GA+V+ +     T L +A +  + + V
Sbjct: 68  EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127

Query: 220 KEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT--YVNIP------------ 265
           K +L+   N N+  +DG T L +A ++GH  +V  L++ GT   V +P            
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187

Query: 266 ---------------DRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAV 310
                           ++G T L  A    ++ + + LL + A ++   Q+  T L+ A 
Sbjct: 188 TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247

Query: 311 EKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDT 370
            +GN  MVR +L      E  TKD  TPL  A +  ++ + E+LLD GA + A  K G +
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307

Query: 371 PLHIAIRGRSRKLAELLLR 389
           P+H+A +G       LLL+
Sbjct: 308 PIHMAAQGDHLDCVRLLLQ 326



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 59/170 (34%), Positives = 92/170 (54%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           ++  +   ++LL+     +  +  G TPL +AA++G+ E+V  L+   AN NL +    T
Sbjct: 611 KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 670

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L   ++EGHV + + L+K GV ++     G+T L  A + G   +V+ LL H A+ +  
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730

Query: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHL 183
                 P+  AA +GH DIV LLL+NGA  N     GTTPL  A R G++
Sbjct: 731 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 63/222 (28%), Positives = 113/222 (50%), Gaps = 7/222 (3%)

Query: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
           A++ T+ + A + G      + L+   ++N  +++G   L +ASKEGH ++V +LL    
Sbjct: 10  ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 69

Query: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320
            +    + G+T L  A   G  E+VR L+   A+++ + Q   T LY A ++ +  +V+ 
Sbjct: 70  ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129

Query: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 380
           +L+   +  + T+DG TPL  A +  +  VV  L++ G K     K     LHIA R   
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDD 185

Query: 381 RKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQI 422
            + A +LL+N  +  +L   +K G TP +I   ++   + Q+
Sbjct: 186 TRTAAVLLQNDPNPDVL---SKTGFTPLHIAAHYENLNVAQL 224



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 50/189 (26%), Positives = 91/189 (48%), Gaps = 12/189 (6%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           +E +   +  LL K  + +  N+ G TPL + A++G++ +   LIK+G   +      +T
Sbjct: 644 QEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYT 703

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L  AS  G++ +V+ LL+   ++  +   G++ L  A  +G TD+V LLL +GA+P+  
Sbjct: 704 PLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEV 763

Query: 134 GLYSVYPIIWAAGRGH---ADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLL 190
                 P+  A   G+    D++ ++    + V  SDK+         R    E V  +L
Sbjct: 764 SSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKH---------RMSFPETVDEIL 814

Query: 191 AMGADVDQE 199
            +  D  +E
Sbjct: 815 DVSEDEGEE 823



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 39/129 (30%), Positives = 63/129 (48%)

Query: 262 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 321
           V   +    T  + A R G+++     L+   DI+   Q+    L+ A ++G+  MV ++
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 322 LQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSR 381
           L      E  TK G T L  A      EVV  L++ GA V+A  +KG TPL++A +    
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 382 KLAELLLRN 390
           ++ + LL N
Sbjct: 125 EVVKFLLEN 133


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  196 bits (498), Expect = 2e-49
 Identities = 136/410 (33%), Positives = 204/410 (49%), Gaps = 9/410 (2%)

Query: 24  LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGH 83
           LL+   + D  ++ G TPL IAA   NL + + L+  GA+ N    +  T L  AS+ G+
Sbjct: 192 LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGN 251

Query: 84  VHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIW 143
           V +V  LL  G  +E +     T L  A   G   + E+LL HGA         + PI  
Sbjct: 252 VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHM 311

Query: 144 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203
           AA   H D V LLLQ  A+++       TPL  AA  GH    K LL  GA  +    N 
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371

Query: 204 MTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN 263
            T L +A K  + + ++ +LK   +++   + G T L +AS  GH  IV++LL  G   N
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431

Query: 264 IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ 323
           + +   +T L  A R GH E+ + LLQ  A ++ + +D++T L+ A   G+  MV+ +L+
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491

Query: 324 CNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKL 383
            N +  + T  G TPL  A +  ++E V  LL+K A  + + KKG TPLH+A +    ++
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551

Query: 384 AELLLRNPKDGRLLYRPNKAGE---TPYNIDCSHQKSILTQIFGARHLSP 430
           AELLL           PN AG+   TP ++   H    + ++   R  SP
Sbjct: 552 AELLLERDA------HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595



 Score =  185 bits (469), Expect = 4e-46
 Identities = 130/395 (32%), Positives = 197/395 (49%), Gaps = 3/395 (0%)

Query: 16  ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
           EN+   + LL +   V+   + G TPL IA+ +GN+ +V+ L+  GA    +  D  T L
Sbjct: 217 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276

Query: 76  ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135
             A++ GHV I E LL  G  ++ +   G + +  A      D V LLL + A      L
Sbjct: 277 HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL 336

Query: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
             + P+  AA  GH  +  +LL  GAK N     G TPL  A +K H+  ++ LL  GA 
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396

Query: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
           +D    + +T L VA   G+   VK +L+R  + N+++    T L +A++ GHTE+ + L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
           L     VN   +   T L  A R GH  +V+ LL+  A+ ++      T L+ A  +G+ 
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHV 516

Query: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
             V  +L+        TK G TPL  A K   + V ELLL++ A  +A  K G TPLH+A
Sbjct: 517 ETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576

Query: 376 IRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 410
           +   +  + +LLL  P+ G   + P   G TP +I
Sbjct: 577 VHHNNLDIVKLLL--PRGGS-PHSPAWNGYTPLHI 608



 Score =  182 bits (463), Expect = 2e-45
 Identities = 130/387 (33%), Positives = 192/387 (49%), Gaps = 3/387 (0%)

Query: 24  LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGH 83
           LL+    +  + + G +P+ +AA+  +L+ V+ L++  A  +   LD+ T L  A+  GH
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 350

Query: 84  VHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIW 143
             + + LL  G     R + G+T L  AC K    V+ELLL  GA+        + P+  
Sbjct: 351 HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV 410

Query: 144 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203
           A+  GH  IV  LLQ GA  N S+    TPL  AAR GH E  K+LL   A V+ +  + 
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470

Query: 204 MTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN 263
            T L  A + G+T  VK +L+ N N NL    G+T L IA++EGH E V  LL+      
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 264 IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ 323
              + G T L  A + G V +   LL++ A  +  G++  T L+ AV   N  +V+ +L 
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590

Query: 324 CNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKL 383
                     +G TPL  A K   +EV   LL  G   +A   +G TPLH+A +    ++
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650

Query: 384 AELLLRNPKDGRLLYRPNKAGETPYNI 410
             LLL    +G L    NK+G TP ++
Sbjct: 651 VALLLSKQANGNL---GNKSGLTPLHL 674



 Score =  178 bits (451), Expect = 5e-44
 Identities = 126/412 (30%), Positives = 206/412 (50%), Gaps = 4/412 (0%)

Query: 16  ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
           +++  ++ LL+   ++D+      TPL +AA  G+  + K L+  GA  N   L+ +T L
Sbjct: 316 DHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 375

Query: 76  ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135
             A K+ HV ++E LLK G +++     G T L  A + G   +V+ LL  GA+P+V+ +
Sbjct: 376 HIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNV 435

Query: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
               P+  AA  GH ++   LLQN AKVN   K   TPL  AAR GH   VK LL   A+
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495

Query: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
            +       T L +A + G+ ++V  +L++  +     K G T L +A+K G   + + L
Sbjct: 496 PNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555

Query: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
           L+   + N   ++G T L  AV   +++IV+ LL +         +  T L+ A ++   
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
            + R +LQ        +  G TPL  A +  + E+V LLL K A  +  +K G TPLH+ 
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 376 IRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARH 427
            +     +A++L+   K G ++    + G TP ++  SH  +I    F  +H
Sbjct: 676 AQEGHVPVADVLI---KHGVMVDATTRMGYTPLHV-ASHYGNIKLVKFLLQH 723



 Score =  172 bits (437), Expect = 2e-42
 Identities = 119/377 (31%), Positives = 190/377 (50%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           ++ ++  ++ LL+    +D   E G TPL +A+  G+L IVK L++ GA+ N+ ++   T
Sbjct: 380 KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVET 439

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L  A++ GH  + + LL+    +  +     T L  A   G T++V+LLL + ANP++ 
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499

Query: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
                 P+  AA  GH + V  LL+  A   C  K G TPL  AA+ G +   + LL   
Sbjct: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559

Query: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
           A  +  G N +T L VAV       VK +L R  + +    +G T L IA+K+   E+ +
Sbjct: 560 AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR 619

Query: 254 DLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKG 313
            LL  G   N     G T L  A + GH E+V  LL K A+ ++  +   T L+   ++G
Sbjct: 620 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEG 679

Query: 314 NATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLH 373
           +  +   +++     +  T+ G TPL  A+   NI++V+ LL   A V+A  K G +PLH
Sbjct: 680 HVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLH 739

Query: 374 IAIRGRSRKLAELLLRN 390
            A +     +  LLL+N
Sbjct: 740 QAAQQGHTDIVTLLLKN 756



 Score =  172 bits (435), Expect = 3e-42
 Identities = 121/376 (32%), Positives = 191/376 (50%), Gaps = 13/376 (3%)

Query: 40  TPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEH 99
           T  + AA  GNL+   + ++NG + N  + +    L  ASKEGHV +V ELL   + LE 
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 100 RDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQN 159
               G TAL  A   G+ +VV  L+++GAN +        P+  AA   H ++V  LL+N
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133

Query: 160 GAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSV 219
           GA  N + + G TPL  A ++GH   V HL+  G     +G   + AL +A +   T++ 
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTA 189

Query: 220 KEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRG 279
             +L+ +PN ++  K G T L IA+   +  + Q LL+ G  VN   ++G T L  A R 
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249

Query: 280 GHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPL 339
           G+V +VR LL + A I+ + +D  T L+ A   G+  +   +L      +  TK+G +P+
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309

Query: 340 IKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYR 399
             A +  +++ V LLL   A++  +     TPLH+A      ++A++LL          +
Sbjct: 310 HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA------K 363

Query: 400 PNKA---GETPYNIDC 412
           PN     G TP +I C
Sbjct: 364 PNSRALNGFTPLHIAC 379



 Score =  161 bits (408), Expect = 5e-39
 Identities = 118/363 (32%), Positives = 179/363 (49%), Gaps = 6/363 (1%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           +E ++  +  LL K   ++   + G T L IAA  G  E+V+EL+  GAN N +    +T
Sbjct: 54  KEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFT 113

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L  A++E H+ +V+ LL+ G N       G+T L  A  +G  +VV  L+++G    V 
Sbjct: 114 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173

Query: 134 GLYSVYPIIWAAGRG-HADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAM 192
                 P +  A R        +LLQN    +   K G TPL  AA   +L   + LL  
Sbjct: 174 -----LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228

Query: 193 GADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIV 252
           GA V+    N +T L +A + G    V+ +L R   +    KD  T L  A++ GH  I 
Sbjct: 229 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288

Query: 253 QDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEK 312
           + LLD G  +    ++G + +  A +G H++ VR LLQ  A+ID    D+ T L+ A   
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348

Query: 313 GNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPL 372
           G+  + + +L           +G TPL  A K  ++ V+ELLL  GA + AV + G TPL
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408

Query: 373 HIA 375
           H+A
Sbjct: 409 HVA 411



 Score =  161 bits (408), Expect = 5e-39
 Identities = 114/361 (31%), Positives = 174/361 (48%)

Query: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
           ++P +K LL++    +  N   +TPL +AA  G+ E+ K L++N A  N +  D+ T L 
Sbjct: 416 HLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLH 475

Query: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
            A++ GH ++V+ LL+   N       G T L  A  +G  + V  LL   A+ +     
Sbjct: 476 CAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK 535

Query: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
              P+  AA  G   +  LLL+  A  N + K G TPL  A    +L+ VK LL  G   
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595

Query: 197 DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLL 256
                N  T L +A K    +  + +L+   + N     G T L +A++EGH E+V  LL
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655

Query: 257 DAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNAT 316
                 N+ ++SG T L    + GHV +   L++    +D   +   T L+ A   GN  
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715

Query: 317 MVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAI 376
           +V+ +LQ   D    TK G +PL +A +  + ++V LLL  GA  + V   G TPL IA 
Sbjct: 716 LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775

Query: 377 R 377
           R
Sbjct: 776 R 776



 Score =  160 bits (404), Expect = 1e-38
 Identities = 124/447 (27%), Positives = 201/447 (44%), Gaps = 34/447 (7%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELI--------------- 58
           +E ++  +K LLE   + +   E G TPL +A +QG+  +V  LI               
Sbjct: 120 QENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHI 179

Query: 59  --------------KNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104
                         +N  N ++     +T L  A+   ++++ + LL  G ++      G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239

Query: 105 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN 164
            T L  A  +G   +V LLL  GA         + P+  AA  GH  I  +LL +GA + 
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQ 299

Query: 165 CSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILK 224
              K G +P+  AA+  HL+CV+ LL   A++D    + +T L VA   G+ +  K +L 
Sbjct: 300 AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLD 359

Query: 225 RNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEI 284
           +    N    +G T L IA K+ H  +++ LL  G  ++    SG T L  A   GH+ I
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419

Query: 285 VRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATK 344
           V+ LLQ+ A  ++     +T L+ A   G+  + + +LQ         KD +TPL  A +
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479

Query: 345 MRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIR-GRSRKLAELLLRNPKDGRLLYRPNKA 403
           + +  +V+LLL+  A  +     G TPLHIA R G    +  LL +      +     K 
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM----TKK 535

Query: 404 GETPYNIDCSHQKSILTQIFGARHLSP 430
           G TP ++   + K  + ++   R   P
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAHP 562



 Score =  159 bits (401), Expect = 3e-38
 Identities = 107/333 (32%), Positives = 168/333 (50%)

Query: 22  KALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKE 81
           K LL+    V+ + +  QTPL  AA  G+  +VK L++N AN NL      T L  A++E
Sbjct: 454 KYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAARE 513

Query: 82  GHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPI 141
           GHV  V  LL+   +       G+T L  A   G+  V ELLL   A+P+  G   + P+
Sbjct: 514 GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL 573

Query: 142 IWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGA 201
             A    + DIV LLL  G   +     G TPL  AA++  +E  + LL  G   + E  
Sbjct: 574 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633

Query: 202 NSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY 261
             +T L +A + G+ + V  +L +  N NL +K G T L + ++EGH  +   L+  G  
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM 693

Query: 262 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 321
           V+   R G T L  A   G++++V+ LLQ  AD++ + +   + L+ A ++G+  +V  +
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753

Query: 322 LQCNPDTEICTKDGETPLIKATKMRNIEVVELL 354
           L+        + DG TPL  A ++  I V ++L
Sbjct: 754 LKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score =  114 bits (284), Expect = 1e-24
 Identities = 88/319 (27%), Positives = 144/319 (45%), Gaps = 29/319 (9%)

Query: 100 RDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQN 159
           R+    T+ + A   G  D     L +G + +      +  +  A+  GH  +V  LL  
Sbjct: 8   READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67

Query: 160 GAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSV 219
              +  + K G T L  AA  G  E V+ L+  GA+V+ +     T L +A +  + + V
Sbjct: 68  EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 127

Query: 220 KEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT--YVNIP------------ 265
           K +L+   N N+  +DG T L +A ++GH  +V  L++ GT   V +P            
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTR 187

Query: 266 ---------------DRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAV 310
                           ++G T L  A    ++ + + LL + A ++   Q+  T L+ A 
Sbjct: 188 TAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247

Query: 311 EKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDT 370
            +GN  MVR +L      E  TKD  TPL  A +  ++ + E+LLD GA + A  K G +
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307

Query: 371 PLHIAIRGRSRKLAELLLR 389
           P+H+A +G       LLL+
Sbjct: 308 PIHMAAQGDHLDCVRLLLQ 326



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 59/170 (34%), Positives = 92/170 (54%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           ++  +   ++LL+     +  +  G TPL +AA++G+ E+V  L+   AN NL +    T
Sbjct: 611 KQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLT 670

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L   ++EGHV + + L+K GV ++     G+T L  A + G   +V+ LL H A+ +  
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730

Query: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHL 183
                 P+  AA +GH DIV LLL+NGA  N     GTTPL  A R G++
Sbjct: 731 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYI 780



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 63/222 (28%), Positives = 113/222 (50%), Gaps = 7/222 (3%)

Query: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
           A++ T+ + A + G      + L+   ++N  +++G   L +ASKEGH ++V +LL    
Sbjct: 10  ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 69

Query: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320
            +    + G+T L  A   G  E+VR L+   A+++ + Q   T LY A ++ +  +V+ 
Sbjct: 70  ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129

Query: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 380
           +L+   +  + T+DG TPL  A +  +  VV  L++ G K     K     LHIA R   
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDD 185

Query: 381 RKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQI 422
            + A +LL+N  +  +L   +K G TP +I   ++   + Q+
Sbjct: 186 TRTAAVLLQNDPNPDVL---SKTGFTPLHIAAHYENLNVAQL 224



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 50/189 (26%), Positives = 91/189 (48%), Gaps = 12/189 (6%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           +E +   +  LL K  + +  N+ G TPL + A++G++ +   LIK+G   +      +T
Sbjct: 644 QEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYT 703

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L  AS  G++ +V+ LL+   ++  +   G++ L  A  +G TD+V LLL +GA+P+  
Sbjct: 704 PLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEV 763

Query: 134 GLYSVYPIIWAAGRGH---ADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLL 190
                 P+  A   G+    D++ ++    + V  SDK+         R    E V  +L
Sbjct: 764 SSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKH---------RMSFPETVDEIL 814

Query: 191 AMGADVDQE 199
            +  D  +E
Sbjct: 815 DVSEDEGEE 823



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 39/129 (30%), Positives = 63/129 (48%)

Query: 262 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 321
           V   +    T  + A R G+++     L+   DI+   Q+    L+ A ++G+  MV ++
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 322 LQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSR 381
           L      E  TK G T L  A      EVV  L++ GA V+A  +KG TPL++A +    
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 382 KLAELLLRN 390
           ++ + LL N
Sbjct: 125 EVVKFLLEN 133


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
           sapiens]
          Length = 2603

 Score =  184 bits (468), Expect = 5e-46
 Identities = 133/407 (32%), Positives = 204/407 (50%), Gaps = 6/407 (1%)

Query: 18  IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLD-NWTALI 76
           +  +K LLE    +++ NE G TPLM A   G++E+ + L++NGA  N    +   +AL 
Sbjct: 347 VDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALT 406

Query: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
            A  +GH+ +V  LL+ G + EH+     TALM AC  G  +V  LLL  GA  ++    
Sbjct: 407 LACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 466

Query: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
              P+  AA  GH ++  LL++ GA +   +  G TPL+ AAR+GH E V  LL  GA++
Sbjct: 467 FESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANI 526

Query: 197 D-QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
           + Q      TAL +A  GG+ +    ++K   ++ L     +T LM A++EGH E+V+ L
Sbjct: 527 NAQTEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLELVKYL 583

Query: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
           L AG  V+    +GDT L  A   GH ++   LLQ  AD++   +  +T L  A   G+ 
Sbjct: 584 LAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHV 643

Query: 316 TMVRDILQCNPDTEICTKDGE-TPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHI 374
             V+ ++    +    T + + T L  A    ++ VVELLL  GA  +   K G T L  
Sbjct: 644 CTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 703

Query: 375 AIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQ 421
           A +G    +   LL  P +      P+    TP + D +    +  Q
Sbjct: 704 AAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQ 750



 Score =  172 bits (436), Expect = 3e-42
 Identities = 120/333 (36%), Positives = 175/333 (52%), Gaps = 7/333 (2%)

Query: 30   DVDERNECGQ-TPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVE 88
            D+D + E    T L +A   G+ E+V+ L++ GA+    D   +T LI A+  GHV +VE
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133

Query: 89   ELLKCGVNLE-HRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGR 147
             LL  G ++E   +    T L  AC  GR +VVELLL+ GAN     +    P+  AA  
Sbjct: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193

Query: 148  GHADIVHLLLQNGAKVN--CSDKYGTTPLVWAARKGHLECVKHLLAMGADVD-QEGANSM 204
            G+ +I+ +LL  GA++N     K G +PL+ AA  GH   VK LL MG+D++ Q   N  
Sbjct: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1253

Query: 205  TALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI 264
            TAL +A   G T+ V  +L R  NV    K G T LM A+  G+ E+ + LLD G  VN 
Sbjct: 1254 TALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1313

Query: 265  P--DRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDIL 322
            P    S DT L  A   GH +    L+ + A ID+R +   T L+ A   G+  +V+ ++
Sbjct: 1314 PPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1373

Query: 323  QCNPDTEICTKDGETPLIKATKMRNIEVVELLL 355
            Q   D +       TPL+ A +  +++VV  L+
Sbjct: 1374 QAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406



 Score =  168 bits (425), Expect = 5e-41
 Identities = 117/380 (30%), Positives = 190/380 (50%), Gaps = 6/380 (1%)

Query: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
           ++  +K LL    DV+ ++  G T L  A   G +++VK L+++GA+    + +  T L+
Sbjct: 313 HVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLM 372

Query: 77  SASKEGHVHIVEELLKCGVNLE-HRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135
            A   GHV +   LL+ G  +  H +    +AL  ACYKG  ++V  LL  GA+      
Sbjct: 373 EAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTD 432

Query: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
                ++ A   GH ++  LLL +GA+VN       +PL  AA  GH+E    L+  GA 
Sbjct: 433 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAS 492

Query: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASKEGHTEIVQD 254
           +++      T L+ A + G+ + V  +L +  N+N  T++   TAL +A   G  E+   
Sbjct: 493 LEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADF 552

Query: 255 LLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGN 314
           L+ AG  + +      T L+ A + GH+E+V+ LL   A++        TAL +A E G+
Sbjct: 553 LIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGH 609

Query: 315 ATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGD-TPLH 373
             +   +LQ   D E  ++ G TPL+KA +  ++  V+ L+ KGA V+      D T L 
Sbjct: 610 TDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLS 669

Query: 374 IAIRGRSRKLAELLLRNPKD 393
           +A  G    + ELLL +  D
Sbjct: 670 LACAGGHLAVVELLLAHGAD 689



 Score =  153 bits (387), Expect = 1e-36
 Identities = 108/323 (33%), Positives = 167/323 (51%), Gaps = 6/323 (1%)

Query: 73   TALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGAN-PS 131
            TAL  A   GH  +V+ LL+ G ++EHRD  G+T L+ A   G   VVE+LL +GA+  +
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144

Query: 132  VTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLA 191
             +      P+  A   G  ++V LLL  GA     +    TPL  AA  G++  +K LL 
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1204

Query: 192  MGADVDQEGANSM--TALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASKEGH 248
             GA+++    + +  + L++A   G+T +VK +L    ++N   + + NTAL +A  +G 
Sbjct: 1205 AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1264

Query: 249  TEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIR--GQDNKTAL 306
            TE+V  LLD    V    ++G T L+ A  GG+ E+ R LL K AD++         TAL
Sbjct: 1265 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1324

Query: 307  YWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDK 366
              A +KG+      ++      ++  K G TPL  A    +++VV+LL+  GA V A D 
Sbjct: 1325 TIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADN 1384

Query: 367  KGDTPLHIAIRGRSRKLAELLLR 389
            +  TPL  A R    K+   L++
Sbjct: 1385 RKITPLMAAFRKGHVKVVRYLVK 1407



 Score =  150 bits (378), Expect = 1e-35
 Identities = 97/309 (31%), Positives = 164/309 (53%), Gaps = 6/309 (1%)

Query: 21   LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLE-DLDNWTALISAS 79
            ++ LLE+   ++ R++ G TPL++AA  G++ +V+ L+ NGA+   + +    T L  A 
Sbjct: 1099 VQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLAC 1158

Query: 80   KEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGA--NPSVTGLYS 137
              G   +VE LL  G N EHR++  +T L  A   G  +++++LL+ GA  N        
Sbjct: 1159 SGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 1218

Query: 138  VYPIIWAAGRGHADIVHLLLQNGAKVNCS-DKYGTTPLVWAARKGHLECVKHLLAMGADV 196
            + P++ AA  GH   V LLL  G+ +N   +    T L  A  +G  E V  LL   A+V
Sbjct: 1219 ISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANV 1278

Query: 197  DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNL--TDKDGNTALMIASKEGHTEIVQD 254
            +      +T L+ A  GGY +  + +L +  +VN        +TAL IA+ +GH +  + 
Sbjct: 1279 EHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1338

Query: 255  LLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGN 314
            L+  G ++++ ++ G+T L  A  GGH+++V+ L+Q  AD+D       T L  A  KG+
Sbjct: 1339 LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGH 1398

Query: 315  ATMVRDILQ 323
              +VR +++
Sbjct: 1399 VKVVRYLVK 1407



 Score =  137 bits (346), Expect = 7e-32
 Identities = 99/335 (29%), Positives = 168/335 (50%), Gaps = 4/335 (1%)

Query: 62  ANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVE 121
           +  N    DN  +L  A  EG V+ V +LL  G ++      G + L  AC  G  ++ +
Sbjct: 226 STANAGQSDN-RSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQ 284

Query: 122 LLLSHGANPSVTGLY-SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARK 180
           +LL+  AN    G+   + P++ AA  GH  IV LLL + A VN     G T L +A   
Sbjct: 285 VLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAG 344

Query: 181 GHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTA 239
           G+++ VK LL  GA ++    N  T L+ A   G+ +  + +L+    +N  +++   +A
Sbjct: 345 GYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESA 404

Query: 240 LMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRG 299
           L +A  +GH E+V+ LL+AG           T L+ A   GHVE+ R LL   A +++  
Sbjct: 405 LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 464

Query: 300 QDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGA 359
              ++ L  A   G+  +   +++     E    +G TPL++A +  + E+V LLL +GA
Sbjct: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGA 524

Query: 360 KVSA-VDKKGDTPLHIAIRGRSRKLAELLLRNPKD 393
            ++A  ++  +T L +A  G   ++A+ L++   D
Sbjct: 525 NINAQTEETQETALTLACCGGFLEVADFLIKAGAD 559



 Score =  137 bits (345), Expect = 9e-32
 Identities = 102/306 (33%), Positives = 158/306 (51%), Gaps = 9/306 (2%)

Query: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
           ++  ++ LLE   D + + +   T LM A   G++E+ + L+ +GA  N+      + L 
Sbjct: 413 HLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 472

Query: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSV-TGL 135
            A+  GHV +   L++ G +LE  +  G+T LM A  +G  ++V LLL  GAN +  T  
Sbjct: 473 LAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEE 532

Query: 136 YSVYPIIWAAGRGHADIVHLLLQNGA--KVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
                +  A   G  ++   L++ GA  ++ CS     TPL+ AA++GHLE VK+LLA G
Sbjct: 533 TQETALTLACCGGFLEVADFLIKAGADIELGCS-----TPLMEAAQEGHLELVKYLLAAG 587

Query: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
           A+V    A   TAL  A + G+T     +L+   ++    + G T LM A++ GH   VQ
Sbjct: 588 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQ 647

Query: 254 DLLDAGTYVNIPDRSGD-TVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEK 312
            L+  G  VN    + D TVL  A  GGH+ +V  LL   AD   R +D  T L  A + 
Sbjct: 648 FLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKG 707

Query: 313 GNATMV 318
           G+ ++V
Sbjct: 708 GHTSVV 713



 Score =  134 bits (336), Expect = 1e-30
 Identities = 96/294 (32%), Positives = 144/294 (48%), Gaps = 6/294 (2%)

Query: 106  TALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNC 165
            TAL  AC  G  ++V+ LL  GA+          P+I AA  GH  +V +LL NGA +  
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144

Query: 166  -SDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILK 224
             S++   TPL  A   G  E V+ LLA GA+ +    +  T L +A  GGY   +K +L 
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1204

Query: 225  RNPNVNLT--DKDGNTALMIASKEGHTEIVQDLLDAGTYVNIP-DRSGDTVLIGAVRGGH 281
                +N     K G + LM+A+  GHT  V+ LLD G+ +N   + + +T L  A   G 
Sbjct: 1205 AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1264

Query: 282  VEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEI--CTKDGETPL 339
             E+V  LL + A+++ R +   T L  A   G A + R +L    D          +T L
Sbjct: 1265 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1324

Query: 340  IKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKD 393
              A    + +  ELL+ +GA +   +KKG+TPL +A  G    + +LL++   D
Sbjct: 1325 TIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGAD 1378



 Score =  122 bits (305), Expect = 4e-27
 Identities = 94/270 (34%), Positives = 136/270 (50%), Gaps = 9/270 (3%)

Query: 144  AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203
            A   GH ++V  LL+ GA +   DK G TPL+ AA  GH+  V+ LL  GAD++ +   +
Sbjct: 1090 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT 1149

Query: 204  M-TALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYV 262
              T L +A  GG  + V+ +L R  N    +    T L +A+  G+  I++ LL+AG  +
Sbjct: 1150 KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI 1209

Query: 263  N--IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNK-TALYWAVEKGNATMVR 319
            N     + G + L+ A   GH   V+ LL   +DI+ + + N+ TAL  A  +G   +V 
Sbjct: 1210 NSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVS 1269

Query: 320  DILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSA--VDKKGDTPLHIAIR 377
             +L    + E   K G TPL++A      EV  +LLDKGA V+A  V    DT L IA  
Sbjct: 1270 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1329

Query: 378  GRSRKLAELLLRNPKDGRLLYRPNKAGETP 407
                K  ELL+     G  +   NK G TP
Sbjct: 1330 KGHYKFCELLIGR---GAHIDVRNKKGNTP 1356



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 70/209 (33%), Positives = 104/209 (49%), Gaps = 11/209 (5%)

Query: 20   ALKALLEKCKDVDERNECGQ-TPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISA 78
            A+K LL+   D++ + E  + T L +A  QG  E+V  L+   AN         T L+ A
Sbjct: 1233 AVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEA 1292

Query: 79   SKEGHVHIVEELLKCG--VNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
            +  G+  +   LL  G  VN         TAL  A  KG     ELL+  GA+  V    
Sbjct: 1293 ASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKK 1352

Query: 137  SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
               P+  AA  GH D+V LL+Q GA V+ +D    TPL+ A RKGH++ V++L+    +V
Sbjct: 1353 GNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV---KEV 1409

Query: 197  DQEGANSMTALIVAVKGGYTQSVKEILKR 225
            +Q  ++S     +A     T + KE+LK+
Sbjct: 1410 NQFPSDSECMRYIA-----TITDKEMLKK 1433



 Score = 85.5 bits (210), Expect = 4e-16
 Identities = 65/201 (32%), Positives = 108/201 (53%), Gaps = 6/201 (2%)

Query: 195  DVD-QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
            D+D Q  +N  TAL +A  GG+ + V+ +L+R  ++   DK G T L++A+  GH  +V+
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133

Query: 254  DLLDAGTYVNI-PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEK 312
             LLD G  +    +R+ DT L  A  GG  E+V  LL + A+ + R   + T L  A   
Sbjct: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193

Query: 313  GNATMVRDILQCNPDTEICT--KDGETPLIKATKMRNIEVVELLLDKGAKVSA-VDKKGD 369
            G   +++ +L    +    T  K G +PL+ A    +   V+LLLD G+ ++A ++   +
Sbjct: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1253

Query: 370  TPLHIA-IRGRSRKLAELLLR 389
            T L +A  +GR+  ++ LL R
Sbjct: 1254 TALTLACFQGRTEVVSLLLDR 1274



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 49/153 (32%), Positives = 73/153 (47%), Gaps = 1/153 (0%)

Query: 6   SQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCN 65
           S  ++   +E ++  +K LL    +V      G T L  A E G+ ++   L++ GA+  
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624

Query: 66  LEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG-WTALMWACYKGRTDVVELLL 124
            E     T L+ A++ GHV  V+ L+  G N+         T L  AC  G   VVELLL
Sbjct: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLL 684

Query: 125 SHGANPSVTGLYSVYPIIWAAGRGHADIVHLLL 157
           +HGA+P+         +I AA  GH  +V  LL
Sbjct: 685 AHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 28/91 (30%), Positives = 48/91 (52%), Gaps = 2/91 (2%)

Query: 336  ETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGR 395
            +T L  A    + E+V+ LL++GA +   DKKG TPL +A       + E+LL N  D  
Sbjct: 1084 DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGAD-- 1141

Query: 396  LLYRPNKAGETPYNIDCSHQKSILTQIFGAR 426
            +  +  +  +TP ++ CS  +  + ++  AR
Sbjct: 1142 IEAQSERTKDTPLSLACSGGRQEVVELLLAR 1172


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
           sapiens]
          Length = 2352

 Score =  184 bits (468), Expect = 5e-46
 Identities = 133/407 (32%), Positives = 204/407 (50%), Gaps = 6/407 (1%)

Query: 18  IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLD-NWTALI 76
           +  +K LLE    +++ NE G TPLM A   G++E+ + L++NGA  N    +   +AL 
Sbjct: 347 VDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALT 406

Query: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
            A  +GH+ +V  LL+ G + EH+     TALM AC  G  +V  LLL  GA  ++    
Sbjct: 407 LACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 466

Query: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
              P+  AA  GH ++  LL++ GA +   +  G TPL+ AAR+GH E V  LL  GA++
Sbjct: 467 FESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANI 526

Query: 197 D-QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
           + Q      TAL +A  GG+ +    ++K   ++ L     +T LM A++EGH E+V+ L
Sbjct: 527 NAQTEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLELVKYL 583

Query: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
           L AG  V+    +GDT L  A   GH ++   LLQ  AD++   +  +T L  A   G+ 
Sbjct: 584 LAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHV 643

Query: 316 TMVRDILQCNPDTEICTKDGE-TPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHI 374
             V+ ++    +    T + + T L  A    ++ VVELLL  GA  +   K G T L  
Sbjct: 644 CTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 703

Query: 375 AIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQ 421
           A +G    +   LL  P +      P+    TP + D +    +  Q
Sbjct: 704 AAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQ 750



 Score =  172 bits (436), Expect = 3e-42
 Identities = 120/333 (36%), Positives = 175/333 (52%), Gaps = 7/333 (2%)

Query: 30   DVDERNECGQ-TPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVE 88
            D+D + E    T L +A   G+ E+V+ L++ GA+    D   +T LI A+  GHV +VE
Sbjct: 823  DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 882

Query: 89   ELLKCGVNLE-HRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGR 147
             LL  G ++E   +    T L  AC  GR +VVELLL+ GAN     +    P+  AA  
Sbjct: 883  ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 942

Query: 148  GHADIVHLLLQNGAKVN--CSDKYGTTPLVWAARKGHLECVKHLLAMGADVD-QEGANSM 204
            G+ +I+ +LL  GA++N     K G +PL+ AA  GH   VK LL MG+D++ Q   N  
Sbjct: 943  GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1002

Query: 205  TALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI 264
            TAL +A   G T+ V  +L R  NV    K G T LM A+  G+ E+ + LLD G  VN 
Sbjct: 1003 TALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1062

Query: 265  P--DRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDIL 322
            P    S DT L  A   GH +    L+ + A ID+R +   T L+ A   G+  +V+ ++
Sbjct: 1063 PPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1122

Query: 323  QCNPDTEICTKDGETPLIKATKMRNIEVVELLL 355
            Q   D +       TPL+ A +  +++VV  L+
Sbjct: 1123 QAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1155



 Score =  168 bits (425), Expect = 5e-41
 Identities = 117/380 (30%), Positives = 190/380 (50%), Gaps = 6/380 (1%)

Query: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
           ++  +K LL    DV+ ++  G T L  A   G +++VK L+++GA+    + +  T L+
Sbjct: 313 HVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLM 372

Query: 77  SASKEGHVHIVEELLKCGVNLE-HRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135
            A   GHV +   LL+ G  +  H +    +AL  ACYKG  ++V  LL  GA+      
Sbjct: 373 EAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTD 432

Query: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
                ++ A   GH ++  LLL +GA+VN       +PL  AA  GH+E    L+  GA 
Sbjct: 433 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAS 492

Query: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASKEGHTEIVQD 254
           +++      T L+ A + G+ + V  +L +  N+N  T++   TAL +A   G  E+   
Sbjct: 493 LEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADF 552

Query: 255 LLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGN 314
           L+ AG  + +      T L+ A + GH+E+V+ LL   A++        TAL +A E G+
Sbjct: 553 LIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGH 609

Query: 315 ATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGD-TPLH 373
             +   +LQ   D E  ++ G TPL+KA +  ++  V+ L+ KGA V+      D T L 
Sbjct: 610 TDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLS 669

Query: 374 IAIRGRSRKLAELLLRNPKD 393
           +A  G    + ELLL +  D
Sbjct: 670 LACAGGHLAVVELLLAHGAD 689



 Score =  153 bits (387), Expect = 1e-36
 Identities = 108/323 (33%), Positives = 167/323 (51%), Gaps = 6/323 (1%)

Query: 73   TALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGAN-PS 131
            TAL  A   GH  +V+ LL+ G ++EHRD  G+T L+ A   G   VVE+LL +GA+  +
Sbjct: 834  TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893

Query: 132  VTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLA 191
             +      P+  A   G  ++V LLL  GA     +    TPL  AA  G++  +K LL 
Sbjct: 894  QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 953

Query: 192  MGADVDQEGANSM--TALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASKEGH 248
             GA+++    + +  + L++A   G+T +VK +L    ++N   + + NTAL +A  +G 
Sbjct: 954  AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1013

Query: 249  TEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIR--GQDNKTAL 306
            TE+V  LLD    V    ++G T L+ A  GG+ E+ R LL K AD++         TAL
Sbjct: 1014 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1073

Query: 307  YWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDK 366
              A +KG+      ++      ++  K G TPL  A    +++VV+LL+  GA V A D 
Sbjct: 1074 TIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADN 1133

Query: 367  KGDTPLHIAIRGRSRKLAELLLR 389
            +  TPL  A R    K+   L++
Sbjct: 1134 RKITPLMAAFRKGHVKVVRYLVK 1156



 Score =  150 bits (378), Expect = 1e-35
 Identities = 97/309 (31%), Positives = 164/309 (53%), Gaps = 6/309 (1%)

Query: 21   LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLE-DLDNWTALISAS 79
            ++ LLE+   ++ R++ G TPL++AA  G++ +V+ L+ NGA+   + +    T L  A 
Sbjct: 848  VQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLAC 907

Query: 80   KEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGA--NPSVTGLYS 137
              G   +VE LL  G N EHR++  +T L  A   G  +++++LL+ GA  N        
Sbjct: 908  SGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 967

Query: 138  VYPIIWAAGRGHADIVHLLLQNGAKVNCS-DKYGTTPLVWAARKGHLECVKHLLAMGADV 196
            + P++ AA  GH   V LLL  G+ +N   +    T L  A  +G  E V  LL   A+V
Sbjct: 968  ISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANV 1027

Query: 197  DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNL--TDKDGNTALMIASKEGHTEIVQD 254
            +      +T L+ A  GGY +  + +L +  +VN        +TAL IA+ +GH +  + 
Sbjct: 1028 EHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCEL 1087

Query: 255  LLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGN 314
            L+  G ++++ ++ G+T L  A  GGH+++V+ L+Q  AD+D       T L  A  KG+
Sbjct: 1088 LIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGH 1147

Query: 315  ATMVRDILQ 323
              +VR +++
Sbjct: 1148 VKVVRYLVK 1156



 Score =  137 bits (346), Expect = 7e-32
 Identities = 99/335 (29%), Positives = 168/335 (50%), Gaps = 4/335 (1%)

Query: 62  ANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVE 121
           +  N    DN  +L  A  EG V+ V +LL  G ++      G + L  AC  G  ++ +
Sbjct: 226 STANAGQSDN-RSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQ 284

Query: 122 LLLSHGANPSVTGLY-SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARK 180
           +LL+  AN    G+   + P++ AA  GH  IV LLL + A VN     G T L +A   
Sbjct: 285 VLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAG 344

Query: 181 GHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTA 239
           G+++ VK LL  GA ++    N  T L+ A   G+ +  + +L+    +N  +++   +A
Sbjct: 345 GYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESA 404

Query: 240 LMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRG 299
           L +A  +GH E+V+ LL+AG           T L+ A   GHVE+ R LL   A +++  
Sbjct: 405 LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 464

Query: 300 QDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGA 359
              ++ L  A   G+  +   +++     E    +G TPL++A +  + E+V LLL +GA
Sbjct: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGA 524

Query: 360 KVSA-VDKKGDTPLHIAIRGRSRKLAELLLRNPKD 393
            ++A  ++  +T L +A  G   ++A+ L++   D
Sbjct: 525 NINAQTEETQETALTLACCGGFLEVADFLIKAGAD 559



 Score =  137 bits (345), Expect = 9e-32
 Identities = 102/306 (33%), Positives = 158/306 (51%), Gaps = 9/306 (2%)

Query: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
           ++  ++ LLE   D + + +   T LM A   G++E+ + L+ +GA  N+      + L 
Sbjct: 413 HLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 472

Query: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSV-TGL 135
            A+  GHV +   L++ G +LE  +  G+T LM A  +G  ++V LLL  GAN +  T  
Sbjct: 473 LAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEE 532

Query: 136 YSVYPIIWAAGRGHADIVHLLLQNGA--KVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
                +  A   G  ++   L++ GA  ++ CS     TPL+ AA++GHLE VK+LLA G
Sbjct: 533 TQETALTLACCGGFLEVADFLIKAGADIELGCS-----TPLMEAAQEGHLELVKYLLAAG 587

Query: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
           A+V    A   TAL  A + G+T     +L+   ++    + G T LM A++ GH   VQ
Sbjct: 588 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQ 647

Query: 254 DLLDAGTYVNIPDRSGD-TVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEK 312
            L+  G  VN    + D TVL  A  GGH+ +V  LL   AD   R +D  T L  A + 
Sbjct: 648 FLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKG 707

Query: 313 GNATMV 318
           G+ ++V
Sbjct: 708 GHTSVV 713



 Score =  134 bits (336), Expect = 1e-30
 Identities = 96/294 (32%), Positives = 144/294 (48%), Gaps = 6/294 (2%)

Query: 106  TALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNC 165
            TAL  AC  G  ++V+ LL  GA+          P+I AA  GH  +V +LL NGA +  
Sbjct: 834  TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893

Query: 166  -SDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILK 224
             S++   TPL  A   G  E V+ LLA GA+ +    +  T L +A  GGY   +K +L 
Sbjct: 894  QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 953

Query: 225  RNPNVNLT--DKDGNTALMIASKEGHTEIVQDLLDAGTYVNIP-DRSGDTVLIGAVRGGH 281
                +N     K G + LM+A+  GHT  V+ LLD G+ +N   + + +T L  A   G 
Sbjct: 954  AGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1013

Query: 282  VEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEI--CTKDGETPL 339
             E+V  LL + A+++ R +   T L  A   G A + R +L    D          +T L
Sbjct: 1014 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1073

Query: 340  IKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKD 393
              A    + +  ELL+ +GA +   +KKG+TPL +A  G    + +LL++   D
Sbjct: 1074 TIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGAD 1127



 Score =  122 bits (305), Expect = 4e-27
 Identities = 94/270 (34%), Positives = 136/270 (50%), Gaps = 9/270 (3%)

Query: 144  AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203
            A   GH ++V  LL+ GA +   DK G TPL+ AA  GH+  V+ LL  GAD++ +   +
Sbjct: 839  ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERT 898

Query: 204  M-TALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYV 262
              T L +A  GG  + V+ +L R  N    +    T L +A+  G+  I++ LL+AG  +
Sbjct: 899  KDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI 958

Query: 263  N--IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNK-TALYWAVEKGNATMVR 319
            N     + G + L+ A   GH   V+ LL   +DI+ + + N+ TAL  A  +G   +V 
Sbjct: 959  NSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVS 1018

Query: 320  DILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSA--VDKKGDTPLHIAIR 377
             +L    + E   K G TPL++A      EV  +LLDKGA V+A  V    DT L IA  
Sbjct: 1019 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1078

Query: 378  GRSRKLAELLLRNPKDGRLLYRPNKAGETP 407
                K  ELL+     G  +   NK G TP
Sbjct: 1079 KGHYKFCELLIGR---GAHIDVRNKKGNTP 1105



 Score =  119 bits (298), Expect = 3e-26
 Identities = 121/413 (29%), Positives = 184/413 (44%), Gaps = 52/413 (12%)

Query: 24   LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDN-WTALISASKEG 82
            LL+   D++  +E G+TPLM AA  G++  V+ LI  GAN N    +N  T L  A   G
Sbjct: 616  LLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGG 675

Query: 83   HVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGAN------PSVTGLY 136
            H+ +VE LL  G +  HR   G T L+ A   G T VV  LL +  N      P VT L 
Sbjct: 676  HLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLT 735

Query: 137  ----------------------------------SVYPIIWAAGRGHADIVHLLLQNGAK 162
                                              +  PI   A  G A  +     +   
Sbjct: 736  PPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIA 795

Query: 163  VNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVD-QEGANSMTALIVAVKGGYTQSVKE 221
             + S     TP    +    L     +     D+D Q  +N  TAL +A  GG+ + V+ 
Sbjct: 796  ASISQPQTPTPSPIISPSAMLPIYPAI-----DIDAQTESNHDTALTLACAGGHEELVQT 850

Query: 222  ILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI-PDRSGDTVLIGAVRGG 280
            +L+R  ++   DK G T L++A+  GH  +V+ LLD G  +    +R+ DT L  A  GG
Sbjct: 851  LLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGG 910

Query: 281  HVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICT--KDGETP 338
              E+V  LL + A+ + R   + T L  A   G   +++ +L    +    T  K G +P
Sbjct: 911  RQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISP 970

Query: 339  LIKATKMRNIEVVELLLDKGAKVSA-VDKKGDTPLHIA-IRGRSRKLAELLLR 389
            L+ A    +   V+LLLD G+ ++A ++   +T L +A  +GR+  ++ LL R
Sbjct: 971  LMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDR 1023



 Score =  115 bits (289), Expect = 3e-25
 Identities = 117/423 (27%), Positives = 181/423 (42%), Gaps = 40/423 (9%)

Query: 6   SQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCN 65
           S  ++   +E ++  +K LL    +V      G T L  A E G+ ++   L++ GA+  
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624

Query: 66  LEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG-WTALMWACYKGRTDVVELLL 124
            E     T L+ A++ GHV  V+ L+  G N+         T L  AC  G   VVELLL
Sbjct: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLL 684

Query: 125 SHGANPSVTGLYSVYPIIWAAGRGHADIVHLLL---QNGAKVNCSDKYGTTPLVWAARKG 181
           +HGA+P+         +I AA  GH  +V  LL    N       D    TP      + 
Sbjct: 685 AHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRA 744

Query: 182 HLECVKHL--LAMGADVDQEGANSMTALIV----------AVKGGYTQSVKEILKR---- 225
               V+ L  +    + D+  AN  T L +          A+    T S+   + +    
Sbjct: 745 PRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTP 804

Query: 226 ------NPNVNL-----------TDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRS 268
                 +P+  L           T+ + +TAL +A   GH E+VQ LL+ G  +   D+ 
Sbjct: 805 TPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKK 864

Query: 269 GDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNK-TALYWAVEKGNATMVRDILQCNPD 327
           G T LI A   GHV +V  LL   ADI+ + +  K T L  A   G   +V  +L    +
Sbjct: 865 GFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGAN 924

Query: 328 TEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSA--VDKKGDTPLHIAIRGRSRKLAE 385
            E       TPL  A     + ++++LL+ GA++++    K G +PL +A         +
Sbjct: 925 KEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVK 984

Query: 386 LLL 388
           LLL
Sbjct: 985 LLL 987



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 70/209 (33%), Positives = 104/209 (49%), Gaps = 11/209 (5%)

Query: 20   ALKALLEKCKDVDERNECGQ-TPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISA 78
            A+K LL+   D++ + E  + T L +A  QG  E+V  L+   AN         T L+ A
Sbjct: 982  AVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEA 1041

Query: 79   SKEGHVHIVEELLKCG--VNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
            +  G+  +   LL  G  VN         TAL  A  KG     ELL+  GA+  V    
Sbjct: 1042 ASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKK 1101

Query: 137  SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
               P+  AA  GH D+V LL+Q GA V+ +D    TPL+ A RKGH++ V++L+    +V
Sbjct: 1102 GNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV---KEV 1158

Query: 197  DQEGANSMTALIVAVKGGYTQSVKEILKR 225
            +Q  ++S     +A     T + KE+LK+
Sbjct: 1159 NQFPSDSECMRYIA-----TITDKEMLKK 1182



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 28/91 (30%), Positives = 48/91 (52%), Gaps = 2/91 (2%)

Query: 336 ETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGR 395
           +T L  A    + E+V+ LL++GA +   DKKG TPL +A       + E+LL N  D  
Sbjct: 833 DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGAD-- 890

Query: 396 LLYRPNKAGETPYNIDCSHQKSILTQIFGAR 426
           +  +  +  +TP ++ CS  +  + ++  AR
Sbjct: 891 IEAQSERTKDTPLSLACSGGRQEVVELLLAR 921


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  184 bits (467), Expect = 7e-46
 Identities = 129/396 (32%), Positives = 205/396 (51%), Gaps = 3/396 (0%)

Query: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
           ++ LLE+   +  R + G +PL +AA+  ++E VK L+++ A  +   LD  TAL  A+ 
Sbjct: 294 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAH 353

Query: 81  EGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYP 140
            GH  + + LL    N   R + G+T L  AC K R  V+ELL+ +GA+        + P
Sbjct: 354 CGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTP 413

Query: 141 IIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEG 200
           I  AA  GH +IV LLLQNGA  + ++  G T L  AAR G +E V+ LL  GA VD   
Sbjct: 414 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 473

Query: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
               T L +A + G T+ V+ +L+   + +    +G T L I+++EG  ++   LL+AG 
Sbjct: 474 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 533

Query: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320
             ++  + G T L  A + G +++ + LLQ+ A  D  G++  T L+ A    N  +   
Sbjct: 534 AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL 593

Query: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 380
           +L+         K+G TPL  A K   +++   LL+ GA+ + V K+G TPLH+A +   
Sbjct: 594 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGH 653

Query: 381 RKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQK 416
             +  LLL     G  ++   K+G T  ++     K
Sbjct: 654 TDMVTLLL---DKGANIHMSTKSGLTSLHLAAQEDK 686



 Score =  183 bits (465), Expect = 1e-45
 Identities = 123/377 (32%), Positives = 197/377 (52%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           ++  I  ++ L++    +    E G TP+ +AA  G+L IV  L++NGA+ ++ ++   T
Sbjct: 386 KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET 445

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
           AL  A++ G V +V  LL+ G  ++ R     T L  A   G+T++V+LLL H A+P   
Sbjct: 446 ALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAA 505

Query: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
                 P+  +A  G  D+  +LL+ GA  + + K G TPL  AA+ G L+  K LL   
Sbjct: 506 TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR 565

Query: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
           A  D  G N +T L VA      +    +L++  + + T K+G T L IA+K+   +I  
Sbjct: 566 AAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAS 625

Query: 254 DLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKG 313
            LL+ G   NI  + G T L  A + GH ++V  LL K A+I +  +   T+L+ A ++ 
Sbjct: 626 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 685

Query: 314 NATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLH 373
              +   + +   D +  TK G TPLI A    N+++V  LL +GA V+A  K G TPLH
Sbjct: 686 KVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLH 745

Query: 374 IAIRGRSRKLAELLLRN 390
            A +     +  +LL++
Sbjct: 746 QAAQQGHTHIINVLLQH 762



 Score =  175 bits (443), Expect = 4e-43
 Identities = 127/385 (32%), Positives = 192/385 (49%), Gaps = 12/385 (3%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           +E ++  ++ LL +   VD   + G T L IA+  G  E+VK L+K GAN N +  + +T
Sbjct: 52  KEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFT 111

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L  A++E H+ +V+ LL+ G N       G+T L  A  +G    V +LL +       
Sbjct: 112 PLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK---- 167

Query: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAK--------VNCSDKYGTTPLVWAARKGHLEC 185
           G   +  +  AA +       LLLQN           VN + + G TPL  AA  G++  
Sbjct: 168 GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNV 227

Query: 186 VKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASK 245
              LL  GA VD    N +T L VA K G T  VK +L R   ++   +DG T L  A++
Sbjct: 228 ATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 287

Query: 246 EGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTA 305
            GH ++V+ LL+ G  +    ++G + L  A +G HVE V+ LLQ  A +D    D  TA
Sbjct: 288 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 347

Query: 306 LYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVD 365
           L+ A   G+  + + +L    +      +G TPL  A K   I+V+ELL+  GA + A+ 
Sbjct: 348 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 407

Query: 366 KKGDTPLHIAIRGRSRKLAELLLRN 390
           + G TP+H+A       +  LLL+N
Sbjct: 408 ESGLTPIHVAAFMGHLNIVLLLLQN 432



 Score =  169 bits (427), Expect = 3e-41
 Identities = 141/490 (28%), Positives = 211/490 (43%), Gaps = 73/490 (14%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGAN---------- 63
           +E +I  +K LLE   +     E G TPL +A +QG+ + V  L++N             
Sbjct: 118 QENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHI 177

Query: 64  ---------------------------CNLEDLDNWTALISASKEGHVHIVEELLKCGVN 96
                                       N      +T L  A+  G+V++   LL  G  
Sbjct: 178 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 237

Query: 97  LEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLL 156
           ++     G T L  A  +G T++V+LLL  G          + P+  AA  GH  +V LL
Sbjct: 238 VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 297

Query: 157 LQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYT 216
           L+ GA +    K G +PL  AA+  H+ECVKHLL   A VD    + +TAL VA   G+ 
Sbjct: 298 LERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 357

Query: 217 QSVKEILKRNPNVNLTDKDGNTALMIASKE------------------------------ 246
           +  K +L +  N N    +G T L IA K+                              
Sbjct: 358 RVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 417

Query: 247 ---GHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNK 303
              GH  IV  LL  G   ++ +  G+T L  A R G VE+VR LL+  A +D R ++ +
Sbjct: 418 AFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ 477

Query: 304 TALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSA 363
           T L+ A   G   +V+ +LQ     +  T +G TPL  + +   ++V  +LL+ GA  S 
Sbjct: 478 TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL 537

Query: 364 VDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIF 423
             KKG TPLH+A +  S  +A+LLL+            K G TP ++   +    +  + 
Sbjct: 538 ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD---SAGKNGLTPLHVAAHYDNQKVALLL 594

Query: 424 GARHLSPTET 433
             +  SP  T
Sbjct: 595 LEKGASPHAT 604



 Score =  164 bits (415), Expect = 7e-40
 Identities = 126/403 (31%), Positives = 192/403 (47%), Gaps = 40/403 (9%)

Query: 45  AAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104
           AA  GNL+ V E +K G + N  + +   AL  A+KEGHV +V+ELL  G +++     G
Sbjct: 17  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76

Query: 105 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN 164
            TAL  A   G+ +VV++L+  GAN +        P+  AA   H D+V  LL+NGA  +
Sbjct: 77  NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 136

Query: 165 CSDKYGTTPLVWAARKGHLECVK----------------HLLAMGAD------------- 195
            + + G TPL  A ++GH + V                 H+ A   D             
Sbjct: 137 TATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHN 196

Query: 196 --------VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEG 247
                   V++   +  T L +A   G       +L R   V+ T ++G T L +ASK G
Sbjct: 197 ADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRG 256

Query: 248 HTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALY 307
           +T +V+ LLD G  ++   R G T L  A R GH ++V  LL++ A +  R ++  + L+
Sbjct: 257 NTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLH 316

Query: 308 WAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKK 367
            A +  +   V+ +LQ     +  T D  T L  A    +  V +LLLDK A  +A    
Sbjct: 317 MAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALN 376

Query: 368 GDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 410
           G TPLHIA +    K+ ELL+   K G  +    ++G TP ++
Sbjct: 377 GFTPLHIACKKNRIKVMELLV---KYGASIQAITESGLTPIHV 416



 Score =  140 bits (352), Expect = 1e-32
 Identities = 99/337 (29%), Positives = 169/337 (50%)

Query: 18  IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALIS 77
           +  ++ LL     VD R    QTPL IA+  G  EIV+ L+++ A+ +    + +T L  
Sbjct: 456 VEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHI 515

Query: 78  ASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYS 137
           +++EG V +   LL+ G         G+T L  A   G  DV +LLL   A     G   
Sbjct: 516 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 575

Query: 138 VYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVD 197
           + P+  AA   +  +  LLL+ GA  + + K G TPL  AA+K  ++    LL  GA+ +
Sbjct: 576 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 635

Query: 198 QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLD 257
                 +T L +A + G+T  V  +L +  N++++ K G T+L +A++E    +   L  
Sbjct: 636 IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 695

Query: 258 AGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATM 317
            G   +   + G T LI A   G+V++V  LL++ A+++ + ++  T L+ A ++G+  +
Sbjct: 696 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHI 755

Query: 318 VRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELL 354
           +  +LQ        T +G T L  A ++  I VV+ L
Sbjct: 756 INVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792



 Score =  113 bits (282), Expect = 2e-24
 Identities = 73/239 (30%), Positives = 118/239 (49%)

Query: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
           ++   K LL++    D   + G TPL +AA   N ++   L++ GA+ +    + +T L 
Sbjct: 554 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLH 613

Query: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
            A+K+  + I   LL  G         G T L  A  +G TD+V LLL  GAN  ++   
Sbjct: 614 IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 673

Query: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
            +  +  AA     ++  +L ++GA  +   K G TPL+ A   G+++ V  LL  GA+V
Sbjct: 674 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 733

Query: 197 DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
           + +  N  T L  A + G+T  +  +L+     N T  +GNTAL IA + G+  +V  L
Sbjct: 734 NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792



 Score =  101 bits (252), Expect = 6e-21
 Identities = 67/215 (31%), Positives = 115/215 (53%), Gaps = 9/215 (4%)

Query: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
           ++S  + + A + G    V E LK   ++N  +++G  AL +A+KEGH  +VQ+LL  G+
Sbjct: 8   SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 67

Query: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320
            V+   + G+T L  A   G  E+V+ L+++ A+I+ + Q+  T LY A ++ +  +V+ 
Sbjct: 68  SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 127

Query: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 380
           +L+   +    T+DG TPL  A +  + + V +LL+   K     K     LHIA R   
Sbjct: 128 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDD 183

Query: 381 RKLAELLLRNPKDG-----RLLYRPNKAGETPYNI 410
            K A LLL+N  +       ++ R  ++G TP +I
Sbjct: 184 TKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 218



 Score = 95.1 bits (235), Expect = 5e-19
 Identities = 66/236 (27%), Positives = 117/236 (49%), Gaps = 25/236 (10%)

Query: 5   ISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANC 64
           I+ +++NY  E NI   +               G TPL +A+++G+ ++V  L+  GAN 
Sbjct: 623 IASTLLNYGAETNIVTKQ---------------GVTPLHLASQEGHTDMVTLLLDKGANI 667

Query: 65  NLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLL 124
           ++      T+L  A++E  V++ + L K G + +     G+T L+ AC+ G   +V  LL
Sbjct: 668 HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 727

Query: 125 SHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLE 184
             GAN +        P+  AA +GH  I+++LLQ+GAK N +   G T L  A R G++ 
Sbjct: 728 KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYIS 787

Query: 185 CVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTAL 240
            V  L      V +E   + T +    K    +++ E+L      +++D++G+  +
Sbjct: 788 VVDTLKV----VTEEVTTTTTTITEKHKLNVPETMTEVL------DVSDEEGDDTM 833



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 48/166 (28%), Positives = 89/166 (53%)

Query: 231 LTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQ 290
           L   D N + + A++ G+ + V + L  G  +N  +++G   L  A + GHV +V+ LL 
Sbjct: 5   LQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64

Query: 291 KYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEV 350
           + + +D   +   TAL+ A   G A +V+ +++   +    +++G TPL  A +  +I+V
Sbjct: 65  RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV 124

Query: 351 VELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRL 396
           V+ LL+ GA  S   + G TPL +A++    +   +LL N   G++
Sbjct: 125 VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV 170


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  184 bits (467), Expect = 7e-46
 Identities = 129/396 (32%), Positives = 205/396 (51%), Gaps = 3/396 (0%)

Query: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
           ++ LLE+   +  R + G +PL +AA+  ++E VK L+++ A  +   LD  TAL  A+ 
Sbjct: 315 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAH 374

Query: 81  EGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYP 140
            GH  + + LL    N   R + G+T L  AC K R  V+ELL+ +GA+        + P
Sbjct: 375 CGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTP 434

Query: 141 IIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEG 200
           I  AA  GH +IV LLLQNGA  + ++  G T L  AAR G +E V+ LL  GA VD   
Sbjct: 435 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 494

Query: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
               T L +A + G T+ V+ +L+   + +    +G T L I+++EG  ++   LL+AG 
Sbjct: 495 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 554

Query: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320
             ++  + G T L  A + G +++ + LLQ+ A  D  G++  T L+ A    N  +   
Sbjct: 555 AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL 614

Query: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 380
           +L+         K+G TPL  A K   +++   LL+ GA+ + V K+G TPLH+A +   
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGH 674

Query: 381 RKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQK 416
             +  LLL     G  ++   K+G T  ++     K
Sbjct: 675 TDMVTLLL---DKGANIHMSTKSGLTSLHLAAQEDK 707



 Score =  183 bits (465), Expect = 1e-45
 Identities = 123/377 (32%), Positives = 197/377 (52%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           ++  I  ++ L++    +    E G TP+ +AA  G+L IV  L++NGA+ ++ ++   T
Sbjct: 407 KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET 466

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
           AL  A++ G V +V  LL+ G  ++ R     T L  A   G+T++V+LLL H A+P   
Sbjct: 467 ALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAA 526

Query: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
                 P+  +A  G  D+  +LL+ GA  + + K G TPL  AA+ G L+  K LL   
Sbjct: 527 TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR 586

Query: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
           A  D  G N +T L VA      +    +L++  + + T K+G T L IA+K+   +I  
Sbjct: 587 AAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAS 646

Query: 254 DLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKG 313
            LL+ G   NI  + G T L  A + GH ++V  LL K A+I +  +   T+L+ A ++ 
Sbjct: 647 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 706

Query: 314 NATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLH 373
              +   + +   D +  TK G TPLI A    N+++V  LL +GA V+A  K G TPLH
Sbjct: 707 KVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLH 766

Query: 374 IAIRGRSRKLAELLLRN 390
            A +     +  +LL++
Sbjct: 767 QAAQQGHTHIINVLLQH 783



 Score =  175 bits (443), Expect = 4e-43
 Identities = 127/385 (32%), Positives = 192/385 (49%), Gaps = 12/385 (3%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           +E ++  ++ LL +   VD   + G T L IA+  G  E+VK L+K GAN N +  + +T
Sbjct: 73  KEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFT 132

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L  A++E H+ +V+ LL+ G N       G+T L  A  +G    V +LL +       
Sbjct: 133 PLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK---- 188

Query: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAK--------VNCSDKYGTTPLVWAARKGHLEC 185
           G   +  +  AA +       LLLQN           VN + + G TPL  AA  G++  
Sbjct: 189 GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNV 248

Query: 186 VKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASK 245
              LL  GA VD    N +T L VA K G T  VK +L R   ++   +DG T L  A++
Sbjct: 249 ATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 308

Query: 246 EGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTA 305
            GH ++V+ LL+ G  +    ++G + L  A +G HVE V+ LLQ  A +D    D  TA
Sbjct: 309 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 368

Query: 306 LYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVD 365
           L+ A   G+  + + +L    +      +G TPL  A K   I+V+ELL+  GA + A+ 
Sbjct: 369 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 428

Query: 366 KKGDTPLHIAIRGRSRKLAELLLRN 390
           + G TP+H+A       +  LLL+N
Sbjct: 429 ESGLTPIHVAAFMGHLNIVLLLLQN 453



 Score =  169 bits (427), Expect = 3e-41
 Identities = 141/490 (28%), Positives = 211/490 (43%), Gaps = 73/490 (14%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGAN---------- 63
           +E +I  +K LLE   +     E G TPL +A +QG+ + V  L++N             
Sbjct: 139 QENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHI 198

Query: 64  ---------------------------CNLEDLDNWTALISASKEGHVHIVEELLKCGVN 96
                                       N      +T L  A+  G+V++   LL  G  
Sbjct: 199 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 258

Query: 97  LEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLL 156
           ++     G T L  A  +G T++V+LLL  G          + P+  AA  GH  +V LL
Sbjct: 259 VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318

Query: 157 LQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYT 216
           L+ GA +    K G +PL  AA+  H+ECVKHLL   A VD    + +TAL VA   G+ 
Sbjct: 319 LERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 378

Query: 217 QSVKEILKRNPNVNLTDKDGNTALMIASKE------------------------------ 246
           +  K +L +  N N    +G T L IA K+                              
Sbjct: 379 RVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438

Query: 247 ---GHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNK 303
              GH  IV  LL  G   ++ +  G+T L  A R G VE+VR LL+  A +D R ++ +
Sbjct: 439 AFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ 498

Query: 304 TALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSA 363
           T L+ A   G   +V+ +LQ     +  T +G TPL  + +   ++V  +LL+ GA  S 
Sbjct: 499 TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL 558

Query: 364 VDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIF 423
             KKG TPLH+A +  S  +A+LLL+            K G TP ++   +    +  + 
Sbjct: 559 ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD---SAGKNGLTPLHVAAHYDNQKVALLL 615

Query: 424 GARHLSPTET 433
             +  SP  T
Sbjct: 616 LEKGASPHAT 625



 Score =  164 bits (415), Expect = 7e-40
 Identities = 126/403 (31%), Positives = 192/403 (47%), Gaps = 40/403 (9%)

Query: 45  AAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104
           AA  GNL+ V E +K G + N  + +   AL  A+KEGHV +V+ELL  G +++     G
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97

Query: 105 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN 164
            TAL  A   G+ +VV++L+  GAN +        P+  AA   H D+V  LL+NGA  +
Sbjct: 98  NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157

Query: 165 CSDKYGTTPLVWAARKGHLECVK----------------HLLAMGAD------------- 195
            + + G TPL  A ++GH + V                 H+ A   D             
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHN 217

Query: 196 --------VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEG 247
                   V++   +  T L +A   G       +L R   V+ T ++G T L +ASK G
Sbjct: 218 ADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRG 277

Query: 248 HTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALY 307
           +T +V+ LLD G  ++   R G T L  A R GH ++V  LL++ A +  R ++  + L+
Sbjct: 278 NTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLH 337

Query: 308 WAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKK 367
            A +  +   V+ +LQ     +  T D  T L  A    +  V +LLLDK A  +A    
Sbjct: 338 MAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALN 397

Query: 368 GDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 410
           G TPLHIA +    K+ ELL+   K G  +    ++G TP ++
Sbjct: 398 GFTPLHIACKKNRIKVMELLV---KYGASIQAITESGLTPIHV 437



 Score =  140 bits (352), Expect = 1e-32
 Identities = 99/337 (29%), Positives = 169/337 (50%)

Query: 18  IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALIS 77
           +  ++ LL     VD R    QTPL IA+  G  EIV+ L+++ A+ +    + +T L  
Sbjct: 477 VEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHI 536

Query: 78  ASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYS 137
           +++EG V +   LL+ G         G+T L  A   G  DV +LLL   A     G   
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 596

Query: 138 VYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVD 197
           + P+  AA   +  +  LLL+ GA  + + K G TPL  AA+K  ++    LL  GA+ +
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 656

Query: 198 QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLD 257
                 +T L +A + G+T  V  +L +  N++++ K G T+L +A++E    +   L  
Sbjct: 657 IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 716

Query: 258 AGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATM 317
            G   +   + G T LI A   G+V++V  LL++ A+++ + ++  T L+ A ++G+  +
Sbjct: 717 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHI 776

Query: 318 VRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELL 354
           +  +LQ        T +G T L  A ++  I VV+ L
Sbjct: 777 INVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score =  113 bits (282), Expect = 2e-24
 Identities = 73/239 (30%), Positives = 118/239 (49%)

Query: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
           ++   K LL++    D   + G TPL +AA   N ++   L++ GA+ +    + +T L 
Sbjct: 575 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLH 634

Query: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
            A+K+  + I   LL  G         G T L  A  +G TD+V LLL  GAN  ++   
Sbjct: 635 IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 694

Query: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
            +  +  AA     ++  +L ++GA  +   K G TPL+ A   G+++ V  LL  GA+V
Sbjct: 695 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 754

Query: 197 DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
           + +  N  T L  A + G+T  +  +L+     N T  +GNTAL IA + G+  +V  L
Sbjct: 755 NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score =  101 bits (252), Expect = 6e-21
 Identities = 67/215 (31%), Positives = 115/215 (53%), Gaps = 9/215 (4%)

Query: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
           ++S  + + A + G    V E LK   ++N  +++G  AL +A+KEGH  +VQ+LL  G+
Sbjct: 29  SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 88

Query: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320
            V+   + G+T L  A   G  E+V+ L+++ A+I+ + Q+  T LY A ++ +  +V+ 
Sbjct: 89  SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148

Query: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 380
           +L+   +    T+DG TPL  A +  + + V +LL+   K     K     LHIA R   
Sbjct: 149 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDD 204

Query: 381 RKLAELLLRNPKDG-----RLLYRPNKAGETPYNI 410
            K A LLL+N  +       ++ R  ++G TP +I
Sbjct: 205 TKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239



 Score = 95.1 bits (235), Expect = 5e-19
 Identities = 66/236 (27%), Positives = 117/236 (49%), Gaps = 25/236 (10%)

Query: 5   ISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANC 64
           I+ +++NY  E NI   +               G TPL +A+++G+ ++V  L+  GAN 
Sbjct: 644 IASTLLNYGAETNIVTKQ---------------GVTPLHLASQEGHTDMVTLLLDKGANI 688

Query: 65  NLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLL 124
           ++      T+L  A++E  V++ + L K G + +     G+T L+ AC+ G   +V  LL
Sbjct: 689 HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 748

Query: 125 SHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLE 184
             GAN +        P+  AA +GH  I+++LLQ+GAK N +   G T L  A R G++ 
Sbjct: 749 KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYIS 808

Query: 185 CVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTAL 240
            V  L      V +E   + T +    K    +++ E+L      +++D++G+  +
Sbjct: 809 VVDTLKV----VTEEVTTTTTTITEKHKLNVPETMTEVL------DVSDEEGDDTM 854


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  184 bits (467), Expect = 7e-46
 Identities = 129/396 (32%), Positives = 205/396 (51%), Gaps = 3/396 (0%)

Query: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
           ++ LLE+   +  R + G +PL +AA+  ++E VK L+++ A  +   LD  TAL  A+ 
Sbjct: 315 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAH 374

Query: 81  EGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYP 140
            GH  + + LL    N   R + G+T L  AC K R  V+ELL+ +GA+        + P
Sbjct: 375 CGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTP 434

Query: 141 IIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEG 200
           I  AA  GH +IV LLLQNGA  + ++  G T L  AAR G +E V+ LL  GA VD   
Sbjct: 435 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 494

Query: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
               T L +A + G T+ V+ +L+   + +    +G T L I+++EG  ++   LL+AG 
Sbjct: 495 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 554

Query: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320
             ++  + G T L  A + G +++ + LLQ+ A  D  G++  T L+ A    N  +   
Sbjct: 555 AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL 614

Query: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 380
           +L+         K+G TPL  A K   +++   LL+ GA+ + V K+G TPLH+A +   
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGH 674

Query: 381 RKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQK 416
             +  LLL     G  ++   K+G T  ++     K
Sbjct: 675 TDMVTLLL---DKGANIHMSTKSGLTSLHLAAQEDK 707



 Score =  183 bits (465), Expect = 1e-45
 Identities = 123/377 (32%), Positives = 197/377 (52%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           ++  I  ++ L++    +    E G TP+ +AA  G+L IV  L++NGA+ ++ ++   T
Sbjct: 407 KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET 466

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
           AL  A++ G V +V  LL+ G  ++ R     T L  A   G+T++V+LLL H A+P   
Sbjct: 467 ALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAA 526

Query: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
                 P+  +A  G  D+  +LL+ GA  + + K G TPL  AA+ G L+  K LL   
Sbjct: 527 TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR 586

Query: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
           A  D  G N +T L VA      +    +L++  + + T K+G T L IA+K+   +I  
Sbjct: 587 AAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAS 646

Query: 254 DLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKG 313
            LL+ G   NI  + G T L  A + GH ++V  LL K A+I +  +   T+L+ A ++ 
Sbjct: 647 TLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQED 706

Query: 314 NATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLH 373
              +   + +   D +  TK G TPLI A    N+++V  LL +GA V+A  K G TPLH
Sbjct: 707 KVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLH 766

Query: 374 IAIRGRSRKLAELLLRN 390
            A +     +  +LL++
Sbjct: 767 QAAQQGHTHIINVLLQH 783



 Score =  175 bits (443), Expect = 4e-43
 Identities = 127/385 (32%), Positives = 192/385 (49%), Gaps = 12/385 (3%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           +E ++  ++ LL +   VD   + G T L IA+  G  E+VK L+K GAN N +  + +T
Sbjct: 73  KEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFT 132

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L  A++E H+ +V+ LL+ G N       G+T L  A  +G    V +LL +       
Sbjct: 133 PLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK---- 188

Query: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAK--------VNCSDKYGTTPLVWAARKGHLEC 185
           G   +  +  AA +       LLLQN           VN + + G TPL  AA  G++  
Sbjct: 189 GKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNV 248

Query: 186 VKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASK 245
              LL  GA VD    N +T L VA K G T  VK +L R   ++   +DG T L  A++
Sbjct: 249 ATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAAR 308

Query: 246 EGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTA 305
            GH ++V+ LL+ G  +    ++G + L  A +G HVE V+ LLQ  A +D    D  TA
Sbjct: 309 SGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 368

Query: 306 LYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVD 365
           L+ A   G+  + + +L    +      +G TPL  A K   I+V+ELL+  GA + A+ 
Sbjct: 369 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 428

Query: 366 KKGDTPLHIAIRGRSRKLAELLLRN 390
           + G TP+H+A       +  LLL+N
Sbjct: 429 ESGLTPIHVAAFMGHLNIVLLLLQN 453



 Score =  169 bits (427), Expect = 3e-41
 Identities = 141/490 (28%), Positives = 211/490 (43%), Gaps = 73/490 (14%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGAN---------- 63
           +E +I  +K LLE   +     E G TPL +A +QG+ + V  L++N             
Sbjct: 139 QENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHI 198

Query: 64  ---------------------------CNLEDLDNWTALISASKEGHVHIVEELLKCGVN 96
                                       N      +T L  A+  G+V++   LL  G  
Sbjct: 199 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 258

Query: 97  LEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLL 156
           ++     G T L  A  +G T++V+LLL  G          + P+  AA  GH  +V LL
Sbjct: 259 VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318

Query: 157 LQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYT 216
           L+ GA +    K G +PL  AA+  H+ECVKHLL   A VD    + +TAL VA   G+ 
Sbjct: 319 LERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 378

Query: 217 QSVKEILKRNPNVNLTDKDGNTALMIASKE------------------------------ 246
           +  K +L +  N N    +G T L IA K+                              
Sbjct: 379 RVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438

Query: 247 ---GHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNK 303
              GH  IV  LL  G   ++ +  G+T L  A R G VE+VR LL+  A +D R ++ +
Sbjct: 439 AFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ 498

Query: 304 TALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSA 363
           T L+ A   G   +V+ +LQ     +  T +G TPL  + +   ++V  +LL+ GA  S 
Sbjct: 499 TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL 558

Query: 364 VDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIF 423
             KKG TPLH+A +  S  +A+LLL+            K G TP ++   +    +  + 
Sbjct: 559 ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD---SAGKNGLTPLHVAAHYDNQKVALLL 615

Query: 424 GARHLSPTET 433
             +  SP  T
Sbjct: 616 LEKGASPHAT 625



 Score =  164 bits (415), Expect = 7e-40
 Identities = 126/403 (31%), Positives = 192/403 (47%), Gaps = 40/403 (9%)

Query: 45  AAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104
           AA  GNL+ V E +K G + N  + +   AL  A+KEGHV +V+ELL  G +++     G
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97

Query: 105 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN 164
            TAL  A   G+ +VV++L+  GAN +        P+  AA   H D+V  LL+NGA  +
Sbjct: 98  NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157

Query: 165 CSDKYGTTPLVWAARKGHLECVK----------------HLLAMGAD------------- 195
            + + G TPL  A ++GH + V                 H+ A   D             
Sbjct: 158 TATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHN 217

Query: 196 --------VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEG 247
                   V++   +  T L +A   G       +L R   V+ T ++G T L +ASK G
Sbjct: 218 ADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRG 277

Query: 248 HTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALY 307
           +T +V+ LLD G  ++   R G T L  A R GH ++V  LL++ A +  R ++  + L+
Sbjct: 278 NTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLH 337

Query: 308 WAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKK 367
            A +  +   V+ +LQ     +  T D  T L  A    +  V +LLLDK A  +A    
Sbjct: 338 MAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALN 397

Query: 368 GDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 410
           G TPLHIA +    K+ ELL+   K G  +    ++G TP ++
Sbjct: 398 GFTPLHIACKKNRIKVMELLV---KYGASIQAITESGLTPIHV 437



 Score =  140 bits (352), Expect = 1e-32
 Identities = 99/337 (29%), Positives = 169/337 (50%)

Query: 18  IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALIS 77
           +  ++ LL     VD R    QTPL IA+  G  EIV+ L+++ A+ +    + +T L  
Sbjct: 477 VEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHI 536

Query: 78  ASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYS 137
           +++EG V +   LL+ G         G+T L  A   G  DV +LLL   A     G   
Sbjct: 537 SAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNG 596

Query: 138 VYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVD 197
           + P+  AA   +  +  LLL+ GA  + + K G TPL  AA+K  ++    LL  GA+ +
Sbjct: 597 LTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN 656

Query: 198 QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLD 257
                 +T L +A + G+T  V  +L +  N++++ K G T+L +A++E    +   L  
Sbjct: 657 IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 716

Query: 258 AGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATM 317
            G   +   + G T LI A   G+V++V  LL++ A+++ + ++  T L+ A ++G+  +
Sbjct: 717 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHI 776

Query: 318 VRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELL 354
           +  +LQ        T +G T L  A ++  I VV+ L
Sbjct: 777 INVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score =  113 bits (282), Expect = 2e-24
 Identities = 73/239 (30%), Positives = 118/239 (49%)

Query: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
           ++   K LL++    D   + G TPL +AA   N ++   L++ GA+ +    + +T L 
Sbjct: 575 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLH 634

Query: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
            A+K+  + I   LL  G         G T L  A  +G TD+V LLL  GAN  ++   
Sbjct: 635 IAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS 694

Query: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
            +  +  AA     ++  +L ++GA  +   K G TPL+ A   G+++ V  LL  GA+V
Sbjct: 695 GLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANV 754

Query: 197 DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
           + +  N  T L  A + G+T  +  +L+     N T  +GNTAL IA + G+  +V  L
Sbjct: 755 NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813



 Score =  101 bits (252), Expect = 6e-21
 Identities = 67/215 (31%), Positives = 115/215 (53%), Gaps = 9/215 (4%)

Query: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
           ++S  + + A + G    V E LK   ++N  +++G  AL +A+KEGH  +VQ+LL  G+
Sbjct: 29  SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 88

Query: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320
            V+   + G+T L  A   G  E+V+ L+++ A+I+ + Q+  T LY A ++ +  +V+ 
Sbjct: 89  SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148

Query: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 380
           +L+   +    T+DG TPL  A +  + + V +LL+   K     K     LHIA R   
Sbjct: 149 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTK----GKVRLPALHIAARKDD 204

Query: 381 RKLAELLLRNPKDG-----RLLYRPNKAGETPYNI 410
            K A LLL+N  +       ++ R  ++G TP +I
Sbjct: 205 TKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239



 Score = 95.1 bits (235), Expect = 5e-19
 Identities = 66/236 (27%), Positives = 117/236 (49%), Gaps = 25/236 (10%)

Query: 5   ISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANC 64
           I+ +++NY  E NI   +               G TPL +A+++G+ ++V  L+  GAN 
Sbjct: 644 IASTLLNYGAETNIVTKQ---------------GVTPLHLASQEGHTDMVTLLLDKGANI 688

Query: 65  NLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLL 124
           ++      T+L  A++E  V++ + L K G + +     G+T L+ AC+ G   +V  LL
Sbjct: 689 HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 748

Query: 125 SHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLE 184
             GAN +        P+  AA +GH  I+++LLQ+GAK N +   G T L  A R G++ 
Sbjct: 749 KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYIS 808

Query: 185 CVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTAL 240
            V  L      V +E   + T +    K    +++ E+L      +++D++G+  +
Sbjct: 809 VVDTLKV----VTEEVTTTTTTITEKHKLNVPETMTEVL------DVSDEEGDDTM 854


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
           [Homo sapiens]
          Length = 2542

 Score =  184 bits (467), Expect = 7e-46
 Identities = 126/379 (33%), Positives = 198/379 (52%), Gaps = 6/379 (1%)

Query: 18  IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLD-NWTALI 76
           +  +K LL +  ++++ NE G TPLM AA  G++E+ + L+ +GA  N    +   +AL 
Sbjct: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 377

Query: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
            A  +GH+ +V  LL+ G + EH+     TALM AC  G  +V  LLL  GA  ++    
Sbjct: 378 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 437

Query: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
              P+  AA  GH ++  LL++ GA +   +  G TPL+ AAR+GH E V  LLA GA++
Sbjct: 438 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497

Query: 197 D-QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
           + Q      TAL +A  GG+++    ++K   ++ L     +T LM AS+EGH E+V+ L
Sbjct: 498 NAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYL 554

Query: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
           L +G  V+    +GDT L  A   GH ++   LLQ  AD++   +  +T L  A   G+ 
Sbjct: 555 LASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHL 614

Query: 316 TMVRDILQCNPDTEICTKDGETPLIK-ATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHI 374
             V+ ++    +    T + +  ++  A    ++ VVELLL  GA  +   K G T L  
Sbjct: 615 CTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 674

Query: 375 AIRGRSRKLAELLLRNPKD 393
           A +G    +   LL  P +
Sbjct: 675 AAKGGHTNVVSYLLDYPNN 693



 Score =  169 bits (427), Expect = 3e-41
 Identities = 119/376 (31%), Positives = 188/376 (50%), Gaps = 6/376 (1%)

Query: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
           +K LL    DV+ ++  G T L  A   G ++IVK L+  GAN    + +  T L+ A+ 
Sbjct: 288 VKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAAS 347

Query: 81  EGHVHIVEELLKCGVNLE-HRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVY 139
            GHV +   LL  G  +  H +    +AL  ACYKG  D+V  LL  GA+          
Sbjct: 348 AGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHT 407

Query: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199
            ++ A   GH ++  LLL +GA+VN       +PL  AA  GH+E    L+  GA++++ 
Sbjct: 408 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEV 467

Query: 200 GANSMTALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASKEGHTEIVQDLLDA 258
                T L+ A + G+ + V  +L +  N+N  T++   TAL +A   G +E+   L+ A
Sbjct: 468 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA 527

Query: 259 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 318
           G  + +      T L+ A + GH+E+V+ LL   A++        TAL +A E G+  + 
Sbjct: 528 GADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVA 584

Query: 319 RDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGD-TPLHIAIR 377
             +LQ   D E  ++ G TPL+KA +  ++  V+ L+ KGA V+      D T + +A  
Sbjct: 585 DVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACA 644

Query: 378 GRSRKLAELLLRNPKD 393
           G    + ELLL +  D
Sbjct: 645 GGHLAVVELLLAHGAD 660



 Score =  166 bits (419), Expect = 2e-40
 Identities = 122/357 (34%), Positives = 179/357 (50%), Gaps = 12/357 (3%)

Query: 6    SQSVINYVEEENIPALKALLEKCKDVDERNECGQ-TPLMIAAEQGNLEIVKELIKNGANC 64
            SQ+  N   +   P   ++     D+D   E    T L +A   G+ E+V  LI   A  
Sbjct: 1027 SQTTSNVASQSMPPVYPSV-----DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKI 1081

Query: 65   NLEDLDNWTALISASKEGHVHIVEELLKCGVNLE-HRDMGGWTALMWACYKGRTDVVELL 123
               D   +T LI A+  GHV +VE LL  G ++E   +    T L  AC  GR +VV+LL
Sbjct: 1082 EHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLL 1141

Query: 124  LSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN--CSDKYGTTPLVWAARKG 181
            L+ GAN     +    P+  AA  G+ +I+ +LL  GA++N     K G +PL+ AA  G
Sbjct: 1142 LARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNG 1201

Query: 182  HLECVKHLLAMGADVD-QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTAL 240
            H+  VK LL MG+D++ Q   N  TAL +A   G  + V  +L R  NV    K G T L
Sbjct: 1202 HVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL 1261

Query: 241  MIASKEGHTEIVQDLLDAGTYVNIP--DRSGDTVLIGAVRGGHVEIVRALLQKYADIDIR 298
            M A+  G+ E+ + LLD G  VN P    S DT L  A   GH +    L+ + A ID+R
Sbjct: 1262 MEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVR 1321

Query: 299  GQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLL 355
             +   T L+ A   G+  +V+ ++Q   D +       TPL+ A +  +++VV+ L+
Sbjct: 1322 NKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378



 Score =  142 bits (358), Expect = 3e-33
 Identities = 107/354 (30%), Positives = 169/354 (47%), Gaps = 18/354 (5%)

Query: 73   TALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSV 132
            TAL  A   GH  +V  L+     +EHRD  G+T L+ A   G   VVE+LL  G +   
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 133  TGLYSV-YPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLA 191
                +   P+  A   G  ++V LLL  GA     +    TPL  AA  G++  +K LL 
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176

Query: 192  MGADVDQEGANSM--TALIVAVKGGYTQSVKEILKRNPNVNLT-DKDGNTALMIASKEGH 248
             GA+++    + +  + L++A   G+  +VK +L    ++N   + + NTAL +A  +G 
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236

Query: 249  TEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRG--QDNKTAL 306
             E+V  LLD    V    ++G T L+ A  GG+ E+ R LL K AD++         TAL
Sbjct: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296

Query: 307  YWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDK 366
              A +KG+      ++      ++  K G TPL  A+   + +VV+LL+  GA V A D 
Sbjct: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356

Query: 367  KGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILT 420
            +  TPL  A R    K+ + L++            +  + P +I+C    + +T
Sbjct: 1357 RKITPLMSAFRKGHVKVVQYLVK------------EVNQFPSDIECMRYIATIT 1398



 Score =  138 bits (347), Expect = 5e-32
 Identities = 102/310 (32%), Positives = 161/310 (51%), Gaps = 9/310 (2%)

Query: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
           ++  ++ LLE   D + + +   T LM A   G++E+ + L+ +GA  N+      + L 
Sbjct: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443

Query: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSV-TGL 135
            A+  GHV +   L++ G NLE  +  G+T LM A  +G  ++V LLL+ GAN +  T  
Sbjct: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503

Query: 136 YSVYPIIWAAGRGHADIVHLLLQNGA--KVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
                +  A   G +++   L++ GA  ++ CS     TPL+ A+++GHLE VK+LLA G
Sbjct: 504 TQETALTLACCGGFSEVADFLIKAGADIELGCS-----TPLMEASQEGHLELVKYLLASG 558

Query: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
           A+V    A   TAL  A + G+T     +L+   ++    + G T LM A++ GH   VQ
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQ 618

Query: 254 DLLDAGTYVNIPDRSGD-TVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEK 312
            L+  G  VN    + D TV+  A  GGH+ +V  LL   AD   R +D  T L  A + 
Sbjct: 619 FLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKG 678

Query: 313 GNATMVRDIL 322
           G+  +V  +L
Sbjct: 679 GHTNVVSYLL 688



 Score =  133 bits (335), Expect = 1e-30
 Identities = 108/354 (30%), Positives = 179/354 (50%), Gaps = 17/354 (4%)

Query: 17   NIPALKALLEKCKDVDERNE-CGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
            ++  ++ LL+K  D++ ++E    TPL +A   G  E+V  L+  GAN    ++ ++T L
Sbjct: 1100 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPL 1159

Query: 76   ISASKEGHVHIVEELLKCGVNLEHRDMG--GWTALMWACYKGRTDVVELLLSHGANPSV- 132
              A+  G+V+I++ LL  G  +  R     G + LM A   G    V+LLL  G++ +  
Sbjct: 1160 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQ 1219

Query: 133  --TGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLL 190
              T   +   +  A  +G A++V LLL   A V    K G TPL+ AA  G+ E  + LL
Sbjct: 1220 IETNRNTALTL--ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1277

Query: 191  AMGADVDQEGANSM--TALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGH 248
              GADV+     S   TAL +A   G+ +  + ++ R  ++++ +K GNT L +AS  GH
Sbjct: 1278 DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGH 1337

Query: 249  TEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYW 308
             ++VQ L+ AG  V+  D    T L+ A R GHV++V+ L++   +++    D +   Y 
Sbjct: 1338 FDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK---EVNQFPSDIECMRYI 1394

Query: 309  AVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVS 362
            A      T    + +C+   E   K  +    +A K  +I + EL L+K  + S
Sbjct: 1395 A----TITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREES 1444



 Score =  122 bits (305), Expect = 4e-27
 Identities = 88/284 (30%), Positives = 142/284 (50%), Gaps = 2/284 (0%)

Query: 107 ALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKV-NC 165
           +L  AC  G  + V  LL  G + +         +  A   G+ ++  +LL   A V + 
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267

Query: 166 SDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKR 225
            +K   TPL+ A+  G+L+ VK LL   ADV+ + A   TAL  A  GG+   VK +L  
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327

Query: 226 NPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI-PDRSGDTVLIGAVRGGHVEI 284
             N+   +++G+T LM A+  GH E+ + LLD G  +N   +   ++ L  A   GH+++
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387

Query: 285 VRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATK 344
           VR LL+  AD + +  +  TAL  A   G+  + R +L       +     E+PL  A  
Sbjct: 388 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447

Query: 345 MRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLL 388
             ++E+  LL+++GA +  V+ +G TPL  A R    ++  LLL
Sbjct: 448 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 491



 Score =  107 bits (268), Expect = 8e-23
 Identities = 81/238 (34%), Positives = 112/238 (47%), Gaps = 32/238 (13%)

Query: 24  LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLE---------------- 67
           L+E+  +++E N+ G TPLM AA +G+ E+V  L+  GAN N +                
Sbjct: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516

Query: 68  ---------------DLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWAC 112
                          +L   T L+ AS+EGH+ +V+ LL  G N+      G TAL +AC
Sbjct: 517 FSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 576

Query: 113 YKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN-CSDKYGT 171
             G TDV ++LL  GA+          P++ AA  GH   V  L+  GA VN  +     
Sbjct: 577 ENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDH 636

Query: 172 TPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNV 229
           T +  A   GHL  V+ LLA GAD      +  T LI A KGG+T  V  +L    NV
Sbjct: 637 TVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 694



 Score = 81.6 bits (200), Expect = 6e-15
 Identities = 61/194 (31%), Positives = 103/194 (53%), Gaps = 5/194 (2%)

Query: 201  ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
            +N  TAL +A  GG+ + V  ++ R+  +   DK G T L++A+  GH  +V+ LLD G 
Sbjct: 1053 SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGG 1112

Query: 261  YVNI-PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVR 319
             +    +R+ DT L  A  GG  E+V  LL + A+ + R   + T L  A   G   +++
Sbjct: 1113 DIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 1172

Query: 320  DILQCNPDTEICT--KDGETPLIKATKMRNIEVVELLLDKGAKVSA-VDKKGDTPLHIA- 375
             +L    +    T  K G +PL+ A    ++  V+LLLD G+ ++A ++   +T L +A 
Sbjct: 1173 ILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLAC 1232

Query: 376  IRGRSRKLAELLLR 389
             +GR+  ++ LL R
Sbjct: 1233 FQGRAEVVSLLLDR 1246



 Score = 67.8 bits (164), Expect = 9e-11
 Identities = 46/145 (31%), Positives = 71/145 (48%), Gaps = 1/145 (0%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           +E ++  +K LL    +V      G T L  A E G+ ++   L++ GA+   E     T
Sbjct: 544 QEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRT 603

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGG-WTALMWACYKGRTDVVELLLSHGANPSV 132
            L+ A++ GH+  V+ L+  G N+         T +  AC  G   VVELLL+HGA+P+ 
Sbjct: 604 PLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTH 663

Query: 133 TGLYSVYPIIWAAGRGHADIVHLLL 157
                   +I AA  GH ++V  LL
Sbjct: 664 RLKDGSTMLIEAAKGGHTNVVSYLL 688



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 51/168 (30%), Positives = 82/168 (48%), Gaps = 6/168 (3%)

Query: 227  PNVNL---TDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVE 283
            P+V++   T+ + +TAL +A   GH E+V  L+     +   D+ G T LI A   GHV 
Sbjct: 1043 PSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVG 1102

Query: 284  IVRALLQKYADIDIRGQDNK-TALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKA 342
            +V  LL K  DI+ + +  K T L  A   G   +V  +L    + E       TPL  A
Sbjct: 1103 VVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162

Query: 343  TKMRNIEVVELLLDKGAKVSA--VDKKGDTPLHIAIRGRSRKLAELLL 388
                 + ++++LL+ GA++++    K G +PL +A         +LLL
Sbjct: 1163 ASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 1210



 Score = 36.2 bits (82), Expect = 0.29
 Identities = 30/96 (31%), Positives = 43/96 (44%), Gaps = 1/96 (1%)

Query: 299 GQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKG 358
           GQ +  +L  A   G+   VR +L         T++GE+ L  A      E+ ++LL   
Sbjct: 202 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 261

Query: 359 AKVSAVDKKGD-TPLHIAIRGRSRKLAELLLRNPKD 393
           A V     KGD TPL  A  G    + +LLL +  D
Sbjct: 262 ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDAD 297


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score =  184 bits (467), Expect = 7e-46
 Identities = 126/379 (33%), Positives = 198/379 (52%), Gaps = 6/379 (1%)

Query: 18  IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLD-NWTALI 76
           +  +K LL +  ++++ NE G TPLM AA  G++E+ + L+ +GA  N    +   +AL 
Sbjct: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 377

Query: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
            A  +GH+ +V  LL+ G + EH+     TALM AC  G  +V  LLL  GA  ++    
Sbjct: 378 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 437

Query: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
              P+  AA  GH ++  LL++ GA +   +  G TPL+ AAR+GH E V  LLA GA++
Sbjct: 438 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497

Query: 197 D-QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
           + Q      TAL +A  GG+++    ++K   ++ L     +T LM AS+EGH E+V+ L
Sbjct: 498 NAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYL 554

Query: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
           L +G  V+    +GDT L  A   GH ++   LLQ  AD++   +  +T L  A   G+ 
Sbjct: 555 LASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHL 614

Query: 316 TMVRDILQCNPDTEICTKDGETPLIK-ATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHI 374
             V+ ++    +    T + +  ++  A    ++ VVELLL  GA  +   K G T L  
Sbjct: 615 CTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 674

Query: 375 AIRGRSRKLAELLLRNPKD 393
           A +G    +   LL  P +
Sbjct: 675 AAKGGHTNVVSYLLDYPNN 693



 Score =  169 bits (427), Expect = 3e-41
 Identities = 119/376 (31%), Positives = 188/376 (50%), Gaps = 6/376 (1%)

Query: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
           +K LL    DV+ ++  G T L  A   G ++IVK L+  GAN    + +  T L+ A+ 
Sbjct: 288 VKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAAS 347

Query: 81  EGHVHIVEELLKCGVNLE-HRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVY 139
            GHV +   LL  G  +  H +    +AL  ACYKG  D+V  LL  GA+          
Sbjct: 348 AGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHT 407

Query: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199
            ++ A   GH ++  LLL +GA+VN       +PL  AA  GH+E    L+  GA++++ 
Sbjct: 408 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEV 467

Query: 200 GANSMTALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASKEGHTEIVQDLLDA 258
                T L+ A + G+ + V  +L +  N+N  T++   TAL +A   G +E+   L+ A
Sbjct: 468 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA 527

Query: 259 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 318
           G  + +      T L+ A + GH+E+V+ LL   A++        TAL +A E G+  + 
Sbjct: 528 GADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVA 584

Query: 319 RDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGD-TPLHIAIR 377
             +LQ   D E  ++ G TPL+KA +  ++  V+ L+ KGA V+      D T + +A  
Sbjct: 585 DVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACA 644

Query: 378 GRSRKLAELLLRNPKD 393
           G    + ELLL +  D
Sbjct: 645 GGHLAVVELLLAHGAD 660



 Score =  166 bits (419), Expect = 2e-40
 Identities = 122/357 (34%), Positives = 179/357 (50%), Gaps = 12/357 (3%)

Query: 6    SQSVINYVEEENIPALKALLEKCKDVDERNECGQ-TPLMIAAEQGNLEIVKELIKNGANC 64
            SQ+  N   +   P   ++     D+D   E    T L +A   G+ E+V  LI   A  
Sbjct: 1027 SQTTSNVASQSMPPVYPSV-----DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKI 1081

Query: 65   NLEDLDNWTALISASKEGHVHIVEELLKCGVNLE-HRDMGGWTALMWACYKGRTDVVELL 123
               D   +T LI A+  GHV +VE LL  G ++E   +    T L  AC  GR +VV+LL
Sbjct: 1082 EHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLL 1141

Query: 124  LSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN--CSDKYGTTPLVWAARKG 181
            L+ GAN     +    P+  AA  G+ +I+ +LL  GA++N     K G +PL+ AA  G
Sbjct: 1142 LARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNG 1201

Query: 182  HLECVKHLLAMGADVD-QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTAL 240
            H+  VK LL MG+D++ Q   N  TAL +A   G  + V  +L R  NV    K G T L
Sbjct: 1202 HVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL 1261

Query: 241  MIASKEGHTEIVQDLLDAGTYVNIP--DRSGDTVLIGAVRGGHVEIVRALLQKYADIDIR 298
            M A+  G+ E+ + LLD G  VN P    S DT L  A   GH +    L+ + A ID+R
Sbjct: 1262 MEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVR 1321

Query: 299  GQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLL 355
             +   T L+ A   G+  +V+ ++Q   D +       TPL+ A +  +++VV+ L+
Sbjct: 1322 NKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378



 Score =  142 bits (358), Expect = 3e-33
 Identities = 107/354 (30%), Positives = 169/354 (47%), Gaps = 18/354 (5%)

Query: 73   TALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSV 132
            TAL  A   GH  +V  L+     +EHRD  G+T L+ A   G   VVE+LL  G +   
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 133  TGLYSV-YPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLA 191
                +   P+  A   G  ++V LLL  GA     +    TPL  AA  G++  +K LL 
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176

Query: 192  MGADVDQEGANSM--TALIVAVKGGYTQSVKEILKRNPNVNLT-DKDGNTALMIASKEGH 248
             GA+++    + +  + L++A   G+  +VK +L    ++N   + + NTAL +A  +G 
Sbjct: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236

Query: 249  TEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRG--QDNKTAL 306
             E+V  LLD    V    ++G T L+ A  GG+ E+ R LL K AD++         TAL
Sbjct: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296

Query: 307  YWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDK 366
              A +KG+      ++      ++  K G TPL  A+   + +VV+LL+  GA V A D 
Sbjct: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356

Query: 367  KGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILT 420
            +  TPL  A R    K+ + L++            +  + P +I+C    + +T
Sbjct: 1357 RKITPLMSAFRKGHVKVVQYLVK------------EVNQFPSDIECMRYIATIT 1398



 Score =  138 bits (347), Expect = 5e-32
 Identities = 102/310 (32%), Positives = 161/310 (51%), Gaps = 9/310 (2%)

Query: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
           ++  ++ LLE   D + + +   T LM A   G++E+ + L+ +GA  N+      + L 
Sbjct: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443

Query: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSV-TGL 135
            A+  GHV +   L++ G NLE  +  G+T LM A  +G  ++V LLL+ GAN +  T  
Sbjct: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503

Query: 136 YSVYPIIWAAGRGHADIVHLLLQNGA--KVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
                +  A   G +++   L++ GA  ++ CS     TPL+ A+++GHLE VK+LLA G
Sbjct: 504 TQETALTLACCGGFSEVADFLIKAGADIELGCS-----TPLMEASQEGHLELVKYLLASG 558

Query: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
           A+V    A   TAL  A + G+T     +L+   ++    + G T LM A++ GH   VQ
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQ 618

Query: 254 DLLDAGTYVNIPDRSGD-TVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEK 312
            L+  G  VN    + D TV+  A  GGH+ +V  LL   AD   R +D  T L  A + 
Sbjct: 619 FLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKG 678

Query: 313 GNATMVRDIL 322
           G+  +V  +L
Sbjct: 679 GHTNVVSYLL 688



 Score =  133 bits (335), Expect = 1e-30
 Identities = 108/354 (30%), Positives = 179/354 (50%), Gaps = 17/354 (4%)

Query: 17   NIPALKALLEKCKDVDERNE-CGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
            ++  ++ LL+K  D++ ++E    TPL +A   G  E+V  L+  GAN    ++ ++T L
Sbjct: 1100 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPL 1159

Query: 76   ISASKEGHVHIVEELLKCGVNLEHRDMG--GWTALMWACYKGRTDVVELLLSHGANPSV- 132
              A+  G+V+I++ LL  G  +  R     G + LM A   G    V+LLL  G++ +  
Sbjct: 1160 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQ 1219

Query: 133  --TGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLL 190
              T   +   +  A  +G A++V LLL   A V    K G TPL+ AA  G+ E  + LL
Sbjct: 1220 IETNRNTALTL--ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1277

Query: 191  AMGADVDQEGANSM--TALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGH 248
              GADV+     S   TAL +A   G+ +  + ++ R  ++++ +K GNT L +AS  GH
Sbjct: 1278 DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGH 1337

Query: 249  TEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYW 308
             ++VQ L+ AG  V+  D    T L+ A R GHV++V+ L++   +++    D +   Y 
Sbjct: 1338 FDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK---EVNQFPSDIECMRYI 1394

Query: 309  AVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVS 362
            A      T    + +C+   E   K  +    +A K  +I + EL L+K  + S
Sbjct: 1395 A----TITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREES 1444



 Score =  122 bits (305), Expect = 4e-27
 Identities = 88/284 (30%), Positives = 142/284 (50%), Gaps = 2/284 (0%)

Query: 107 ALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKV-NC 165
           +L  AC  G  + V  LL  G + +         +  A   G+ ++  +LL   A V + 
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267

Query: 166 SDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKR 225
            +K   TPL+ A+  G+L+ VK LL   ADV+ + A   TAL  A  GG+   VK +L  
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327

Query: 226 NPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI-PDRSGDTVLIGAVRGGHVEI 284
             N+   +++G+T LM A+  GH E+ + LLD G  +N   +   ++ L  A   GH+++
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387

Query: 285 VRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATK 344
           VR LL+  AD + +  +  TAL  A   G+  + R +L       +     E+PL  A  
Sbjct: 388 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447

Query: 345 MRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLL 388
             ++E+  LL+++GA +  V+ +G TPL  A R    ++  LLL
Sbjct: 448 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 491



 Score =  107 bits (268), Expect = 8e-23
 Identities = 81/238 (34%), Positives = 112/238 (47%), Gaps = 32/238 (13%)

Query: 24  LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLE---------------- 67
           L+E+  +++E N+ G TPLM AA +G+ E+V  L+  GAN N +                
Sbjct: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516

Query: 68  ---------------DLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWAC 112
                          +L   T L+ AS+EGH+ +V+ LL  G N+      G TAL +AC
Sbjct: 517 FSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 576

Query: 113 YKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN-CSDKYGT 171
             G TDV ++LL  GA+          P++ AA  GH   V  L+  GA VN  +     
Sbjct: 577 ENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDH 636

Query: 172 TPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNV 229
           T +  A   GHL  V+ LLA GAD      +  T LI A KGG+T  V  +L    NV
Sbjct: 637 TVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 694



 Score = 81.6 bits (200), Expect = 6e-15
 Identities = 61/194 (31%), Positives = 103/194 (53%), Gaps = 5/194 (2%)

Query: 201  ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
            +N  TAL +A  GG+ + V  ++ R+  +   DK G T L++A+  GH  +V+ LLD G 
Sbjct: 1053 SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGG 1112

Query: 261  YVNI-PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVR 319
             +    +R+ DT L  A  GG  E+V  LL + A+ + R   + T L  A   G   +++
Sbjct: 1113 DIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 1172

Query: 320  DILQCNPDTEICT--KDGETPLIKATKMRNIEVVELLLDKGAKVSA-VDKKGDTPLHIA- 375
             +L    +    T  K G +PL+ A    ++  V+LLLD G+ ++A ++   +T L +A 
Sbjct: 1173 ILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLAC 1232

Query: 376  IRGRSRKLAELLLR 389
             +GR+  ++ LL R
Sbjct: 1233 FQGRAEVVSLLLDR 1246



 Score = 67.8 bits (164), Expect = 9e-11
 Identities = 46/145 (31%), Positives = 71/145 (48%), Gaps = 1/145 (0%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           +E ++  +K LL    +V      G T L  A E G+ ++   L++ GA+   E     T
Sbjct: 544 QEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRT 603

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGG-WTALMWACYKGRTDVVELLLSHGANPSV 132
            L+ A++ GH+  V+ L+  G N+         T +  AC  G   VVELLL+HGA+P+ 
Sbjct: 604 PLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTH 663

Query: 133 TGLYSVYPIIWAAGRGHADIVHLLL 157
                   +I AA  GH ++V  LL
Sbjct: 664 RLKDGSTMLIEAAKGGHTNVVSYLL 688



 Score = 64.7 bits (156), Expect = 8e-10
 Identities = 51/168 (30%), Positives = 82/168 (48%), Gaps = 6/168 (3%)

Query: 227  PNVNL---TDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVE 283
            P+V++   T+ + +TAL +A   GH E+V  L+     +   D+ G T LI A   GHV 
Sbjct: 1043 PSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVG 1102

Query: 284  IVRALLQKYADIDIRGQDNK-TALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKA 342
            +V  LL K  DI+ + +  K T L  A   G   +V  +L    + E       TPL  A
Sbjct: 1103 VVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162

Query: 343  TKMRNIEVVELLLDKGAKVSA--VDKKGDTPLHIAIRGRSRKLAELLL 388
                 + ++++LL+ GA++++    K G +PL +A         +LLL
Sbjct: 1163 ASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 1210



 Score = 36.2 bits (82), Expect = 0.29
 Identities = 30/96 (31%), Positives = 43/96 (44%), Gaps = 1/96 (1%)

Query: 299 GQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKG 358
           GQ +  +L  A   G+   VR +L         T++GE+ L  A      E+ ++LL   
Sbjct: 202 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 261

Query: 359 AKVSAVDKKGD-TPLHIAIRGRSRKLAELLLRNPKD 393
           A V     KGD TPL  A  G    + +LLL +  D
Sbjct: 262 ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDAD 297


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  177 bits (450), Expect = 6e-44
 Identities = 119/402 (29%), Positives = 200/402 (49%), Gaps = 3/402 (0%)

Query: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
           ++ LL++   +  + + G +PL +A +  +L  V+ L+++    +    D  TAL  A+ 
Sbjct: 317 VEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAH 376

Query: 81  EGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYP 140
            GH  + + LL    N   + + G+T L  AC K R  V+ELLL HGA+        + P
Sbjct: 377 CGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTP 436

Query: 141 IIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEG 200
           I  AA  GH +IV  L+ +GA  N ++  G T L  AAR G  E V++L+  GA V+ + 
Sbjct: 437 IHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKA 496

Query: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
            +  T L ++ + G    V+++L++  + N     G T L ++++EGH ++   LLD G 
Sbjct: 497 KDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGA 556

Query: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320
            ++I  + G T L  A + G +E+   LLQK A  D  G+   T L+ A    N  +   
Sbjct: 557 SLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALL 616

Query: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRS 380
           +L          K+G TPL  A K   +++   LL+ GA  +AV ++G   +H+A +   
Sbjct: 617 LLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGH 676

Query: 381 RKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQI 422
             +  LLL    +  L    NK+G TP ++     +  + ++
Sbjct: 677 VDMVSLLLGRNANVNL---SNKSGLTPLHLAAQEDRVNVAEV 715



 Score =  175 bits (444), Expect = 3e-43
 Identities = 114/377 (30%), Positives = 187/377 (49%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           ++  I  ++ LL+    +    E G TP+ +AA  G++ IV +L+ +GA+ N  ++   T
Sbjct: 409 KKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGET 468

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
           AL  A++ G   +V  L++ G  +E +     T L  +   G+ D+V+ LL  GA+P+  
Sbjct: 469 ALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAA 528

Query: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
                 P+  +A  GH D+   LL +GA ++ + K G TPL  AA+ G LE    LL   
Sbjct: 529 TTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKS 588

Query: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
           A  D  G + +T L VA      +    +L +  + +   K+G T L IA+K+   +I  
Sbjct: 589 ASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIAT 648

Query: 254 DLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKG 313
            LL+ G   N   R G   +  A + GHV++V  LL + A++++  +   T L+ A ++ 
Sbjct: 649 TLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQED 708

Query: 314 NATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLH 373
              +   ++      +  TK G TPL       NI++V  LL   AKV+A  K G TPLH
Sbjct: 709 RVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLH 768

Query: 374 IAIRGRSRKLAELLLRN 390
            A +     +  +LL+N
Sbjct: 769 QAAQQGHTHIINVLLQN 785



 Score =  172 bits (437), Expect = 2e-42
 Identities = 119/362 (32%), Positives = 179/362 (49%), Gaps = 4/362 (1%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           +E ++  +  LL++  +VD   + G T L IA+  G  E+VK L+ NGAN N +  + +T
Sbjct: 83  KEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFT 142

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            L  A++E H+ +V+ LL  G +       G+T L  A  +G   VV LLL +       
Sbjct: 143 PLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTK 198

Query: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
           G   +  +  AA +       LLLQN    +   K G TPL  AA  G++     LL   
Sbjct: 199 GKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRA 258

Query: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
           A VD    N +T L VA K G    VK +L R   ++   +DG T L   ++ GH ++V+
Sbjct: 259 AAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVE 318

Query: 254 DLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKG 313
            LLD    +    ++G + L  A +G H+  V+ LLQ    +D    D  TAL+ A   G
Sbjct: 319 MLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCG 378

Query: 314 NATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLH 373
           +  + + +L    +      +G TPL  A K   I+V+ELLL  GA + AV + G TP+H
Sbjct: 379 HYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIH 438

Query: 374 IA 375
           +A
Sbjct: 439 VA 440



 Score =  170 bits (431), Expect = 1e-41
 Identities = 135/472 (28%), Positives = 210/472 (44%), Gaps = 65/472 (13%)

Query: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
           +K L+    +V+ +++ G TPL +AA++ +LE+VK L+ NGA+ +L   D +T L  A +
Sbjct: 123 VKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQ 182

Query: 81  EGHVHIVEELLKCGV-----------------------------NLEHRDMGGWTALMWA 111
           +GH  +V  LL+                                N +     G+T L  A
Sbjct: 183 QGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIA 242

Query: 112 CYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGT 171
            + G  +V  LLL+  A    T    + P+  A+ RG+A++V LLL  GAK++   + G 
Sbjct: 243 AHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGL 302

Query: 172 TPLVWAARKGH---------------------------------LECVKHLLAMGADVDQ 198
           TPL   AR GH                                 L CV+ LL     VD 
Sbjct: 303 TPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDD 362

Query: 199 EGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDA 258
              + +TAL VA   G+ +  K +L +  N N    +G T L IA K+   ++++ LL  
Sbjct: 363 VTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKH 422

Query: 259 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 318
           G  +     SG T +  A   GHV IV  L+   A  +      +TAL+ A   G A +V
Sbjct: 423 GASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVV 482

Query: 319 RDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRG 378
           R ++Q     E   KD +TPL  + ++   ++V+ LL +GA  +A    G TPLH++ R 
Sbjct: 483 RYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSARE 542

Query: 379 RSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSP 430
               +A  LL +   G  L    K G TP ++   + K  +  +   +  SP
Sbjct: 543 GHEDVAAFLLDH---GASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP 591



 Score =  167 bits (422), Expect = 1e-40
 Identities = 125/395 (31%), Positives = 190/395 (48%), Gaps = 32/395 (8%)

Query: 45  AAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104
           AA  G+LE   + IKNG + N+ + +   AL  ASKEGHV +V ELL+   N++     G
Sbjct: 48  AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107

Query: 105 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN 164
            TAL  A   G+ +VV++L+++GAN +        P+  AA   H ++V  LL NGA  +
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQS 167

Query: 165 CSDKYGTTPLVWAARKGHLECVK----------------HLLAMGAD------------- 195
            + + G TPL  A ++GH + V                 H+ A   D             
Sbjct: 168 LATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNN 227

Query: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
            D E  +  T L +A   G       +L R   V+ T ++  T L +ASK G+  +V+ L
Sbjct: 228 ADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLL 287

Query: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
           LD G  ++   R G T L    R GH ++V  LL + A I  + ++  + L+ A +  + 
Sbjct: 288 LDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHL 347

Query: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
             V+ +LQ N   +  T D  T L  A    + +V ++LLDK A  +A    G TPLHIA
Sbjct: 348 NCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIA 407

Query: 376 IRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 410
            +    K+ ELLL   K G  +    ++G TP ++
Sbjct: 408 CKKNRIKVMELLL---KHGASIQAVTESGLTPIHV 439



 Score =  164 bits (414), Expect = 9e-40
 Identities = 116/383 (30%), Positives = 180/383 (46%)

Query: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
           N   +K LL++   +D +   G TPL   A  G+ ++V+ L+   A    +  +  + L 
Sbjct: 280 NANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLH 339

Query: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
            A++  H++ V+ LL+  V ++       TAL  A + G   V ++LL   ANP+   L 
Sbjct: 340 MATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALN 399

Query: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
              P+  A  +    ++ LLL++GA +    + G TP+  AA  GH+  V  L+  GA  
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP 459

Query: 197 DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLL 256
           +       TAL +A + G  + V+ +++    V    KD  T L I+++ G  +IVQ LL
Sbjct: 460 NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLL 519

Query: 257 DAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNAT 316
             G   N    SG T L  + R GH ++   LL   A + I  +   T L+ A + G   
Sbjct: 520 QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLE 579

Query: 317 MVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAI 376
           +   +LQ +   +   K G TPL  A    N +V  LLLD+GA   A  K G TPLHIA 
Sbjct: 580 VANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAA 639

Query: 377 RGRSRKLAELLLRNPKDGRLLYR 399
           +     +A  LL    D   + R
Sbjct: 640 KKNQMDIATTLLEYGADANAVTR 662



 Score =  164 bits (414), Expect = 9e-40
 Identities = 119/411 (28%), Positives = 198/411 (48%), Gaps = 3/411 (0%)

Query: 22  KALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKE 81
           K LL+K  + + +   G TPL IA ++  +++++ L+K+GA+         T +  A+  
Sbjct: 384 KVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFM 443

Query: 82  GHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPI 141
           GHV+IV +L+  G +    ++ G TAL  A   G+ +VV  L+  GA           P+
Sbjct: 444 GHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPL 503

Query: 142 IWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGA 201
             +A  G ADIV  LLQ GA  N +   G TPL  +AR+GH +    LL  GA +     
Sbjct: 504 HISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTK 563

Query: 202 NSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY 261
              T L VA K G  +    +L+++ + +   K G T L +A+   + ++   LLD G  
Sbjct: 564 KGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGAS 623

Query: 262 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 321
            +   ++G T L  A +   ++I   LL+  AD +   +    +++ A ++G+  MV  +
Sbjct: 624 PHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLL 683

Query: 322 LQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSR 381
           L  N +  +  K G TPL  A +   + V E+L+++GA V A  K G TPLH+     + 
Sbjct: 684 LGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNI 743

Query: 382 KLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTE 432
           K+   LL++      +    K G TP +       + +  +    + SP E
Sbjct: 744 KIVNFLLQH---SAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNE 791



 Score =  159 bits (403), Expect = 2e-38
 Identities = 102/334 (30%), Positives = 174/334 (52%)

Query: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
           ++ L++    V+ + +  QTPL I+A  G  +IV++L++ GA+ N      +T L  +++
Sbjct: 482 VRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAR 541

Query: 81  EGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYP 140
           EGH  +   LL  G +L      G+T L  A   G+ +V  LLL   A+P   G   + P
Sbjct: 542 EGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTP 601

Query: 141 IIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEG 200
           +  AA   +  +  LLL  GA  + + K G TPL  AA+K  ++    LL  GAD +   
Sbjct: 602 LHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVT 661

Query: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
              + ++ +A + G+   V  +L RN NVNL++K G T L +A++E    + + L++ G 
Sbjct: 662 RQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGA 721

Query: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320
           +V+   + G T L      G+++IV  LLQ  A ++ + ++  T L+ A ++G+  ++  
Sbjct: 722 HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINV 781

Query: 321 ILQCNPDTEICTKDGETPLIKATKMRNIEVVELL 354
           +LQ N      T +G T L  A ++  I VV+ L
Sbjct: 782 LLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815



 Score =  155 bits (391), Expect = 4e-37
 Identities = 103/343 (30%), Positives = 168/343 (48%)

Query: 35  NECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCG 94
           N  G+T L +AA  G  E+V+ L+++GA    +  D+ T L  +++ G   IV++LL+ G
Sbjct: 463 NVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQG 522

Query: 95  VNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVH 154
            +       G+T L  +  +G  DV   LL HGA+ S+T      P+  AA  G  ++ +
Sbjct: 523 ASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVAN 582

Query: 155 LLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGG 214
           LLLQ  A  + + K G TPL  AA   + +    LL  GA       N  T L +A K  
Sbjct: 583 LLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKN 642

Query: 215 YTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLI 274
                  +L+   + N   + G  ++ +A++EGH ++V  LL     VN+ ++SG T L 
Sbjct: 643 QMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLH 702

Query: 275 GAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKD 334
            A +   V +   L+ + A +D + +   T L+     GN  +V  +LQ +      TK+
Sbjct: 703 LAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKN 762

Query: 335 GETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIR 377
           G TPL +A +  +  ++ +LL   A  + +   G+T L IA R
Sbjct: 763 GYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARR 805



 Score =  147 bits (370), Expect = 1e-34
 Identities = 100/315 (31%), Positives = 162/315 (51%), Gaps = 4/315 (1%)

Query: 76  ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135
           + A++ GH+    + +K GV++   +  G  AL  A  +G  +VV  LL   AN      
Sbjct: 46  LRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATK 105

Query: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
                +  A+  G A++V +L+ NGA VN   + G TPL  AA++ HLE VK LL  GA 
Sbjct: 106 KGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS 165

Query: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
                 +  T L VA++ G+ Q V  +L+ +       K    AL IA+++  T+    L
Sbjct: 166 QSLATEDGFTPLAVALQQGHDQVVSLLLENDTK----GKVRLPALHIAARKDDTKAAALL 221

Query: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
           L      ++  +SG T L  A   G++ +   LL + A +D   +++ T L+ A ++GNA
Sbjct: 222 LQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNA 281

Query: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
            MV+ +L      +  T+DG TPL    +  + +VVE+LLD+ A + +  K G +PLH+A
Sbjct: 282 NMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMA 341

Query: 376 IRGRSRKLAELLLRN 390
            +G      +LLL++
Sbjct: 342 TQGDHLNCVQLLLQH 356



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 54/162 (33%), Positives = 90/162 (55%)

Query: 235 DGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYAD 294
           D N + + A++ GH E   D +  G  +NI +++G   L  A + GHVE+V  LLQ+ A+
Sbjct: 40  DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN 99

Query: 295 IDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELL 354
           +D   +   TAL+ A   G A +V+ ++    +    +++G TPL  A +  ++EVV+ L
Sbjct: 100 VDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFL 159

Query: 355 LDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRL 396
           LD GA  S   + G TPL +A++    ++  LLL N   G++
Sbjct: 160 LDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKV 201



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 33/110 (30%), Positives = 58/110 (52%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           +E+ +   + L+ +   VD + + G TPL +    GN++IV  L+++ A  N +  + +T
Sbjct: 706 QEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYT 765

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELL 123
            L  A+++GH HI+  LL+   +     + G TAL  A   G   VV+ L
Sbjct: 766 PLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 31/118 (26%), Positives = 63/118 (53%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           +E ++  +  LL +  +V+  N+ G TPL +AA++  + + + L+  GA+ + +    +T
Sbjct: 673 QEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYT 732

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPS 131
            L      G++ IV  LL+    +  +   G+T L  A  +G T ++ +LL + A+P+
Sbjct: 733 PLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPN 790


>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
           [Homo sapiens]
          Length = 627

 Score =  167 bits (422), Expect = 1e-40
 Identities = 120/394 (30%), Positives = 210/394 (53%), Gaps = 12/394 (3%)

Query: 6   SQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCN 65
           ++S+     + ++ A++ LL++ + V+E  E G++ L +A   G  E+ + L+    + N
Sbjct: 206 TRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL--AMHAN 263

Query: 66  LEDLDNW---TALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVEL 122
           +ED  N    T L++AS  G++ IV+ LL    ++  +   G TAL +AC  G  D+V++
Sbjct: 264 VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 323

Query: 123 LLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNC-SDKYGTTPLVWAARKG 181
           LL+ GAN          P++ AA  GH ++  +LL +GA +N  S+++  + L  A  KG
Sbjct: 324 LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 383

Query: 182 HLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALM 241
           HL+ V+ LL  GAD + +     TAL+ A   G+ +  + +L     VN+      + L 
Sbjct: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443

Query: 242 IASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQD 301
           +A+  GH E+   L++ G  +   +  G T L+ A R GH E+V  LL + A+I+ + ++
Sbjct: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503

Query: 302 -NKTALYWAVEKGNATMVRDILQCNPDTEI-CTKDGETPLIKATKMRNIEVVELLLDKGA 359
             +TAL  A   G + +   +++   D E+ C+    TPL++A++  ++E+V+ LL  GA
Sbjct: 504 TQETALTLACCGGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGA 559

Query: 360 KVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKD 393
            V A    GDT L  A       +A++LL+   D
Sbjct: 560 NVHATTATGDTALTYACENGHTDVADVLLQAGAD 593



 Score =  166 bits (421), Expect = 1e-40
 Identities = 107/291 (36%), Positives = 163/291 (56%), Gaps = 6/291 (2%)

Query: 18  IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLD-NWTALI 76
           +  +K LL +  ++++ NE G TPLM AA  G++E+ + L+ +GA  N    +   +AL 
Sbjct: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 377

Query: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
            A  +GH+ +V  LL+ G + EH+     TALM AC  G  +V  LLL  GA  ++    
Sbjct: 378 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 437

Query: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
              P+  AA  GH ++  LL++ GA +   +  G TPL+ AAR+GH E V  LLA GA++
Sbjct: 438 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497

Query: 197 D-QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
           + Q      TAL +A  GG+++    ++K   ++ L     +T LM AS+EGH E+V+ L
Sbjct: 498 NAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYL 554

Query: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTAL 306
           L +G  V+    +GDT L  A   GH ++   LLQ  AD+D + +D KT L
Sbjct: 555 LASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQEDMKTIL 604



 Score =  139 bits (349), Expect = 3e-32
 Identities = 97/311 (31%), Positives = 154/311 (49%), Gaps = 5/311 (1%)

Query: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
           +K LL    DV+ ++  G T L  A   G ++IVK L+  GAN    + +  T L+ A+ 
Sbjct: 288 VKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAAS 347

Query: 81  EGHVHIVEELLKCGVNLE-HRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVY 139
            GHV +   LL  G  +  H +    +AL  ACYKG  D+V  LL  GA+          
Sbjct: 348 AGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHT 407

Query: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199
            ++ A   GH ++  LLL +GA+VN       +PL  AA  GH+E    L+  GA++++ 
Sbjct: 408 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEV 467

Query: 200 GANSMTALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASKEGHTEIVQDLLDA 258
                T L+ A + G+ + V  +L +  N+N  T++   TAL +A   G +E+   L+ A
Sbjct: 468 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA 527

Query: 259 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 318
           G  + +      T L+ A + GH+E+V+ LL   A++        TAL +A E G+  + 
Sbjct: 528 GADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVA 584

Query: 319 RDILQCNPDTE 329
             +LQ   D +
Sbjct: 585 DVLLQAGADLD 595



 Score = 36.2 bits (82), Expect = 0.29
 Identities = 30/96 (31%), Positives = 43/96 (44%), Gaps = 1/96 (1%)

Query: 299 GQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKG 358
           GQ +  +L  A   G+   VR +L         T++GE+ L  A      E+ ++LL   
Sbjct: 202 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 261

Query: 359 AKVSAVDKKGD-TPLHIAIRGRSRKLAELLLRNPKD 393
           A V     KGD TPL  A  G    + +LLL +  D
Sbjct: 262 ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDAD 297


>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
           [Homo sapiens]
          Length = 616

 Score =  167 bits (422), Expect = 1e-40
 Identities = 120/394 (30%), Positives = 210/394 (53%), Gaps = 12/394 (3%)

Query: 6   SQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCN 65
           ++S+     + ++ A++ LL++ + V+E  E G++ L +A   G  E+ + L+    + N
Sbjct: 195 TRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL--AMHAN 252

Query: 66  LEDLDNW---TALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVEL 122
           +ED  N    T L++AS  G++ IV+ LL    ++  +   G TAL +AC  G  D+V++
Sbjct: 253 VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 312

Query: 123 LLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNC-SDKYGTTPLVWAARKG 181
           LL+ GAN          P++ AA  GH ++  +LL +GA +N  S+++  + L  A  KG
Sbjct: 313 LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 372

Query: 182 HLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALM 241
           HL+ V+ LL  GAD + +     TAL+ A   G+ +  + +L     VN+      + L 
Sbjct: 373 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 432

Query: 242 IASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQD 301
           +A+  GH E+   L++ G  +   +  G T L+ A R GH E+V  LL + A+I+ + ++
Sbjct: 433 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492

Query: 302 -NKTALYWAVEKGNATMVRDILQCNPDTEI-CTKDGETPLIKATKMRNIEVVELLLDKGA 359
             +TAL  A   G + +   +++   D E+ C+    TPL++A++  ++E+V+ LL  GA
Sbjct: 493 TQETALTLACCGGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGA 548

Query: 360 KVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKD 393
            V A    GDT L  A       +A++LL+   D
Sbjct: 549 NVHATTATGDTALTYACENGHTDVADVLLQAGAD 582



 Score =  166 bits (421), Expect = 1e-40
 Identities = 107/291 (36%), Positives = 163/291 (56%), Gaps = 6/291 (2%)

Query: 18  IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLD-NWTALI 76
           +  +K LL +  ++++ NE G TPLM AA  G++E+ + L+ +GA  N    +   +AL 
Sbjct: 307 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 366

Query: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
            A  +GH+ +V  LL+ G + EH+     TALM AC  G  +V  LLL  GA  ++    
Sbjct: 367 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 426

Query: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
              P+  AA  GH ++  LL++ GA +   +  G TPL+ AAR+GH E V  LLA GA++
Sbjct: 427 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 486

Query: 197 D-QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
           + Q      TAL +A  GG+++    ++K   ++ L     +T LM AS+EGH E+V+ L
Sbjct: 487 NAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYL 543

Query: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTAL 306
           L +G  V+    +GDT L  A   GH ++   LLQ  AD+D + +D KT L
Sbjct: 544 LASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQEDMKTIL 593



 Score =  139 bits (349), Expect = 3e-32
 Identities = 97/311 (31%), Positives = 154/311 (49%), Gaps = 5/311 (1%)

Query: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
           +K LL    DV+ ++  G T L  A   G ++IVK L+  GAN    + +  T L+ A+ 
Sbjct: 277 VKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAAS 336

Query: 81  EGHVHIVEELLKCGVNLE-HRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVY 139
            GHV +   LL  G  +  H +    +AL  ACYKG  D+V  LL  GA+          
Sbjct: 337 AGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHT 396

Query: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199
            ++ A   GH ++  LLL +GA+VN       +PL  AA  GH+E    L+  GA++++ 
Sbjct: 397 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEV 456

Query: 200 GANSMTALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASKEGHTEIVQDLLDA 258
                T L+ A + G+ + V  +L +  N+N  T++   TAL +A   G +E+   L+ A
Sbjct: 457 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA 516

Query: 259 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 318
           G  + +      T L+ A + GH+E+V+ LL   A++        TAL +A E G+  + 
Sbjct: 517 GADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVA 573

Query: 319 RDILQCNPDTE 329
             +LQ   D +
Sbjct: 574 DVLLQAGADLD 584



 Score = 36.2 bits (82), Expect = 0.29
 Identities = 30/96 (31%), Positives = 43/96 (44%), Gaps = 1/96 (1%)

Query: 299 GQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKG 358
           GQ +  +L  A   G+   VR +L         T++GE+ L  A      E+ ++LL   
Sbjct: 191 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 250

Query: 359 AKVSAVDKKGD-TPLHIAIRGRSRKLAELLLRNPKD 393
           A V     KGD TPL  A  G    + +LLL +  D
Sbjct: 251 ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDAD 286


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  166 bits (421), Expect = 1e-40
 Identities = 128/419 (30%), Positives = 191/419 (45%), Gaps = 39/419 (9%)

Query: 24  LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNW-----TALISA 78
           L+ K +DV+  +   +TPL +AA  G+ EI++ LI +GA  N +D + W      A+ S 
Sbjct: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKD-NMWLTPLHRAVASR 60

Query: 79  SKEG----------------------HVHIVEELLKCG-------VNLEHRDMGGWTALM 109
           S+E                       HV    + +KC         ++   D GG TAL 
Sbjct: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120

Query: 110 WACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKY 169
            A   G  ++V LLL+ GAN +         + WAA  GH D+V LL+ +GA+V C DK 
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180

Query: 170 GTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNV 229
           G TPL  AA  G +  VKHLL +G ++D+      TAL +A   G    V E++    NV
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240

Query: 230 NLTDKDGNTALMIASKEGHTEIVQDLL-DAGTYVNIPDRSGDTVLIGAVRGGHVEIVRAL 288
           N  + +G T L  A+   H  +  +LL + G  VNI  + G + L      G     + L
Sbjct: 241 NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300

Query: 289 LQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNI 348
           +Q   +ID   +D  T L+ A   G+  ++  +     DT  C      PL  A    + 
Sbjct: 301 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360

Query: 349 EVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETP 407
           +    LL  G ++   DK G T LH A  G + +  +LL  +  D    ++ +K G TP
Sbjct: 361 DCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGAD---FHKKDKCGRTP 416



 Score =  155 bits (392), Expect = 3e-37
 Identities = 113/357 (31%), Positives = 168/357 (47%), Gaps = 1/357 (0%)

Query: 20  ALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISAS 79
           A++ L++   DV+ R++  QTPL +AA    ++  + +I   ++ N+ D    TAL  A+
Sbjct: 64  AVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAA 123

Query: 80  KEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVY 139
             GHV +V  LL  G N+   D     AL WA Y G  DVV LL++HGA  +        
Sbjct: 124 LNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYT 183

Query: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199
           P+  AA  G  ++V  LL  G +++  + YG T L  A   G    V  L+  GA+V+Q 
Sbjct: 184 PLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQP 243

Query: 200 GANSMTALIVAVKGGYTQSVKEILKRN-PNVNLTDKDGNTALMIASKEGHTEIVQDLLDA 258
             N  T L  A    +     E+L  N  +VN+  KDG + L + +  G     Q L+  
Sbjct: 244 NNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQN 303

Query: 259 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 318
           G  ++  D+ G+T L  A R GH  ++  L    AD    G  +   L+ A    ++   
Sbjct: 304 GGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCC 363

Query: 319 RDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
           R +L    + +   K G T L  A    N+E ++LL   GA     DK G TPLH A
Sbjct: 364 RKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420



 Score =  140 bits (353), Expect = 1e-32
 Identities = 115/418 (27%), Positives = 188/418 (44%), Gaps = 51/418 (12%)

Query: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
           ++  +  LL K  +++  ++  +  L  AA  G+L++V  LI +GA    +D   +T L 
Sbjct: 127 HVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLH 186

Query: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
           +A+  G +++V+ LL  GV ++  ++ G TAL  ACY G+  VV  L+ +GAN +     
Sbjct: 187 AAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNN 246

Query: 137 SVYPIIWAAGRGH------------ADI---------------VH-------LLLQNGAK 162
              P+ +AA   H            AD+               VH        L+QNG +
Sbjct: 247 GFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGE 306

Query: 163 VNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEI 222
           ++C DK G TPL  AAR GH   +  L   GAD  + G +SM  L +A    ++   +++
Sbjct: 307 IDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKL 366

Query: 223 LKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHV 282
           L     ++  DK G T L  A+  G+ E ++ L  +G   +  D+ G T L  A    H 
Sbjct: 367 LSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHF 426

Query: 283 EIVRALLQKYADIDIRGQDNKTALYWAVEKG---NATMVRDILQCNPDTEICTKDGETPL 339
             +  L+   A+++      +TAL++A       N T++ +             D    L
Sbjct: 427 HCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGN-----------AHDNSEEL 475

Query: 340 IKATKMRNIEV---VELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDG 394
            +A +++  E    +E LL   A  S  DK+G   +H A     R+  ELLL     G
Sbjct: 476 ERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSG 533



 Score =  139 bits (351), Expect = 2e-32
 Identities = 128/431 (29%), Positives = 199/431 (46%), Gaps = 45/431 (10%)

Query: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNW--TA 74
           N+  +K L     D  ++++CG+TPL  AA   +   ++ L+  GAN N  + D+W  TA
Sbjct: 392 NVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVN--ETDDWGRTA 449

Query: 75  LISASKE---------GHVH-------------------IVEELLKCGVNLEHRDMGGWT 106
           L  A+           G+ H                    +E LL+   N   RD  G+ 
Sbjct: 450 LHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYN 509

Query: 107 ALMWACYKGRTDVVELLLSH---GANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKV 163
           ++ +A   G    +ELLL     G   S +G  +  P+  AA  GH   + +LLQ+   +
Sbjct: 510 SIHYAAAYGHRQCLELLLERTNSGFEESDSGA-TKSPLHLAAYNGHHQALEVLLQSLVDL 568

Query: 164 NCSDKYGTTPLVWAARKGHLECVKHLLAMGADVD-QEGANSMTALIVAVKGGYTQSVKEI 222
           +  D+ G T L  AA KGH ECV+ L+  GA +  ++     T L  +V  G+T  ++ +
Sbjct: 569 DIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLL 628

Query: 223 LKRNPN---VNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRG 279
           L+   N   V++ D  G T LM+A   GH + V  LL+    V+  D  G T L   +  
Sbjct: 629 LEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMT 688

Query: 280 GHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ-CNPDTEICTKD--GE 336
           GH E V+ LL++   I  +    +T L++A  +G+AT + ++LQ    + + C KD  G 
Sbjct: 689 GHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGY 748

Query: 337 TPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRL 396
           TPL  A    N   +E+LL++      +     TPLH AI       A LLL    D  +
Sbjct: 749 TPLHWACYNGNENCIEVLLEQKCFRKFIGNP-FTPLHCAIINDHGNCASLLL-GAIDSSI 806

Query: 397 LYRPNKAGETP 407
           +   +  G TP
Sbjct: 807 VSCRDDKGRTP 817



 Score =  120 bits (302), Expect = 9e-27
 Identities = 88/316 (27%), Positives = 148/316 (46%), Gaps = 6/316 (1%)

Query: 106 TALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNC 165
           T L  A + G  +++ELL+  GA  +      + P+  A      + V +L+++ A VN 
Sbjct: 18  TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA 77

Query: 166 SDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKR 225
            DK   TPL  AA    ++C + ++ + + V+       TAL  A   G+ + V  +L +
Sbjct: 78  RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAK 137

Query: 226 NPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIV 285
             N+N  DK    AL  A+  GH ++V  L++ G  V   D+ G T L  A   G + +V
Sbjct: 138 GANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVV 197

Query: 286 RALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPL-IKATK 344
           + LL    +ID       TAL+ A   G   +V +++    +      +G TPL   A  
Sbjct: 198 KHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAAS 257

Query: 345 MRNIEVVELLLDKGAKVSAVDKKGDTPLHI-AIRGRSRKLAELLLRNPKDGRLLYRPNKA 403
                 +ELL++ GA V+   K G +PLH+ A+ GR  +   L+    ++G  +   +K 
Sbjct: 258 THGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLI----QNGGEIDCVDKD 313

Query: 404 GETPYNIDCSHQKSIL 419
           G TP ++   +   +L
Sbjct: 314 GNTPLHVAARYGHELL 329



 Score =  117 bits (294), Expect = 8e-26
 Identities = 87/283 (30%), Positives = 133/283 (46%), Gaps = 4/283 (1%)

Query: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199
           P+  AA  G A+I+ LL+ +GA+VN  D    TPL  A      E V+ L+   ADV+  
Sbjct: 19  PLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNAR 78

Query: 200 GANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAG 259
             N  T L VA      +  + I+    +VN++D+ G TAL  A+  GH E+V  LL  G
Sbjct: 79  DKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKG 138

Query: 260 TYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVR 319
             +N  D+     L  A   GH+++V  L+   A++  + +   T L+ A   G   +V+
Sbjct: 139 ANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVK 198

Query: 320 DILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGR 379
            +L    + +     G T L  A       VV  L+D GA V+  +  G TPLH A    
Sbjct: 199 HLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAAST 258

Query: 380 SRKLA-ELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQ 421
              L  ELL+ N  D  +    +K G++P ++   H +   +Q
Sbjct: 259 HGALCLELLVNNGADVNI---QSKDGKSPLHMTAVHGRFTRSQ 298



 Score =  117 bits (294), Expect = 8e-26
 Identities = 108/417 (25%), Positives = 184/417 (44%), Gaps = 34/417 (8%)

Query: 24  LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKEL-IKNGANCNLEDLDNWTALISASKEG 82
           L++   +V++ N  G TPL  AA   +  +  EL + NGA+ N++  D  + L   +  G
Sbjct: 233 LIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHG 292

Query: 83  HVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPII 142
                + L++ G  ++  D  G T L  A   G   ++  L + GA+ +  G++S++P+ 
Sbjct: 293 RFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLH 352

Query: 143 WAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGAN 202
            AA   H+D    LL +G +++  DK+G T L  AA  G++EC+K L + GAD  ++   
Sbjct: 353 LAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKC 412

Query: 203 SMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIAS------------------ 244
             T L  A    +   ++ ++    NVN TD  G TAL  A+                  
Sbjct: 413 GRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNS 472

Query: 245 ----------KEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYAD 294
                     ++  T  ++ LL      +I D+ G   +  A   GH + +  LL++  +
Sbjct: 473 EELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLER-TN 531

Query: 295 IDIRGQDN---KTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVV 351
                 D+   K+ L+ A   G+   +  +LQ   D +I  + G T L  A    + E V
Sbjct: 532 SGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECV 591

Query: 352 ELLLDKGAKVSAVDK-KGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETP 407
           E L++ GA +   D     TPLH ++         LLL    +   +   +  G+TP
Sbjct: 592 EALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 648



 Score =  110 bits (274), Expect = 2e-23
 Identities = 79/254 (31%), Positives = 127/254 (50%), Gaps = 5/254 (1%)

Query: 155 LLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGG 214
           +L+     VN  D    TPL  AA  G  E ++ L+  GA V+ +    +T L  AV   
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 215 YTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLI 274
             ++V+ ++K + +VN  DK+  T L +A+     +  + ++   + VN+ DR G T L 
Sbjct: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120

Query: 275 GAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKD 334
            A   GHVE+V  LL K A+I+   + ++ AL+WA   G+  +V  ++    +     K 
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180

Query: 335 GETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA-IRGRSRKLAELLLRNPKD 393
           G TPL  A     I VV+ LL+ G ++  ++  G+T LHIA   G+   + EL+      
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELI----DY 236

Query: 394 GRLLYRPNKAGETP 407
           G  + +PN  G TP
Sbjct: 237 GANVNQPNNNGFTP 250



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 81/248 (32%), Positives = 122/248 (49%), Gaps = 9/248 (3%)

Query: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
           +I A+  LLEK  +VD  +  G T L      G+ E V+ L++   +   +D    T L 
Sbjct: 657 HIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLH 716

Query: 77  SASKEGHVHIVEELLKCGVNLEH---RDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
            A+  GH   + ELL+  ++ E    +D  G+T L WACY G  + +E+LL         
Sbjct: 717 YAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFI 776

Query: 134 GLYSVYPIIWAAGRGHADIVHLLLQ--NGAKVNCSDKYGTTPLVWAARKGHLECVKHLLA 191
           G     P+  A    H +   LLL   + + V+C D  G TPL  AA   H+EC++ LL 
Sbjct: 777 G-NPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLR 835

Query: 192 MGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLT--DKDGNTALMIASKEGHT 249
             A V+    +  TAL++A + G   +V +IL  +   +LT  DKD NT L +A  +GH 
Sbjct: 836 HSAPVNAVDNSGKTALMMAAENGQAGAV-DILVNSAQADLTVKDKDLNTPLHLACSKGHE 894

Query: 250 EIVQDLLD 257
           +    +LD
Sbjct: 895 KCALLILD 902


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  165 bits (417), Expect = 4e-40
 Identities = 118/357 (33%), Positives = 172/357 (48%), Gaps = 1/357 (0%)

Query: 20  ALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISAS 79
           A++ LL+   DV+ R++  QTPL IAA    ++  + L+   +N N+ D    TAL  A+
Sbjct: 89  AVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAA 148

Query: 80  KEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVY 139
             GH  +V+ LL  G N+   D     A+ WA Y G  +VV+LL+SHGA  +     S  
Sbjct: 149 FSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYT 208

Query: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199
           P+  AA  G   +V  LL  G  +N  + YG TPL  A   G    V  L+  GA V+Q+
Sbjct: 209 PLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQK 268

Query: 200 GANSMTALIVAVKGGYTQSVKEILKRN-PNVNLTDKDGNTALMIASKEGHTEIVQDLLDA 258
                T L  A    +     E+L  N  +VN+  KDG T L + +  G     Q ++ +
Sbjct: 269 NEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQS 328

Query: 259 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 318
           G  ++  D++G+T L  A R GH  ++  L+   AD   RG      L+ A   G +   
Sbjct: 329 GAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCC 388

Query: 319 RDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
           R +L    D +     G T L  A    N+E + LLL+ GA  +  DK G +PLH A
Sbjct: 389 RKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYA 445



 Score =  149 bits (375), Expect = 3e-35
 Identities = 134/501 (26%), Positives = 229/501 (45%), Gaps = 13/501 (2%)

Query: 18  IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALIS 77
           +   +AL+    +V+  +  G+T L  AA  G+ E+VK L+  GAN N  D  +  A+  
Sbjct: 120 VKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHW 179

Query: 78  ASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYS 137
           A+  GH+ +V+ L+  G  +  +D   +T L  A   G   VV+ LL  G + +    Y 
Sbjct: 180 AAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYG 239

Query: 138 VYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGH-LECVKHLLAMGADV 196
             P+  A   G   +V+ L+  GA VN  ++ G TPL +AA   H   C++ L+  GADV
Sbjct: 240 NTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADV 299

Query: 197 DQEGANSMTAL-IVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
           + +  +  T L + A+ G +++S + I++    ++  DK+GNT L IA++ GH  ++  L
Sbjct: 300 NMKSKDGKTPLHMTALHGRFSRS-QTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTL 358

Query: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
           + +G         G   L  A   G  +  R LL    DID      +T L+ A   GN 
Sbjct: 359 ITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNL 418

Query: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
             +  +L    D     K G +PL  A    N + +  L+  GA V+ +D++G TPLH A
Sbjct: 419 ECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYA 478

Query: 376 IRG-RSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETD 434
                  K  E LLRN  +  +    +K G    +   ++   +  Q+        +ET 
Sbjct: 479 ATSDTDGKCLEYLLRNDANPGI---RDKQGYNAVHYSAAYGHRLCLQLIA------SETP 529

Query: 435 GDMLGYDLYSSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPL 494
            D+L     +  L+D  +  T+ P      +    + +  +   L+ +++  +G+    L
Sbjct: 530 LDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDL 589

Query: 495 FQFSWLIVFLTLLLCGGLGLL 515
             F   +  + +L+  G  +L
Sbjct: 590 AAFKGHVECVDVLINQGASIL 610



 Score =  147 bits (372), Expect = 7e-35
 Identities = 110/356 (30%), Positives = 170/356 (47%), Gaps = 1/356 (0%)

Query: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
           ++AL+ K +DV+ ++   +TPL  AA  G+ EI++ LI +GA  N +D    T L  A  
Sbjct: 24  VRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVA 83

Query: 81  EGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYP 140
                 V+ LLK   ++  RD    T L  A         E L+   +N +V+       
Sbjct: 84  SCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTA 143

Query: 141 IIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEG 200
           +  AA  GH ++V LLL  GA +N  DK     + WAA  GH+E VK L++ GA+V  + 
Sbjct: 144 LHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKD 203

Query: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
             S T L  A   G    VK +L    ++N  +  GNT L +A   G   +V +L+D G 
Sbjct: 204 KKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA 263

Query: 261 YVNIPDRSGDTVLIGAVRGGHVEI-VRALLQKYADIDIRGQDNKTALYWAVEKGNATMVR 319
            VN  +  G T L  A    H  + +  L+   AD++++ +D KT L+     G  +  +
Sbjct: 264 IVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQ 323

Query: 320 DILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
            I+Q     +   K+G TPL  A +  +  ++  L+  GA  +     G  PLH+A
Sbjct: 324 TIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLA 379



 Score =  142 bits (359), Expect = 2e-33
 Identities = 123/400 (30%), Positives = 177/400 (44%), Gaps = 50/400 (12%)

Query: 20  ALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANC--------------- 64
           AL+ L++   D+D RN  G+TPL +AA +G++E V  LI  GA+                
Sbjct: 565 ALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAA 624

Query: 65  ----------------------NLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDM 102
                                 +++D +  T L+ +   GH   V  LL  G N++ +D 
Sbjct: 625 ATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDK 684

Query: 103 GGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAK 162
            G TAL      G  + V+ LL HGA   +       PI  +A  GH  ++  LLQ+ A 
Sbjct: 685 WGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAAS 744

Query: 163 VNCS----DKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAV---KGGY 215
           ++ +    D +G T L WA   GH  CV+ LL        EG N+ + L  AV     G 
Sbjct: 745 MDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEG-NAFSPLHCAVINDNEGA 803

Query: 216 TQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIG 275
            + + + L  +  VN TD  G T L  A+   H E +Q LL     VN  D +G T L+ 
Sbjct: 804 AEMLIDTLGASI-VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMM 862

Query: 276 AVRGGHVEIVRALLQKY-ADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKD 334
           A   G    V  L+    A++ ++     TAL+ A  KG+ T    IL+   D  +    
Sbjct: 863 AAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINAT 922

Query: 335 G---ETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTP 371
               +TPL  A +     VV+ LL KGA V AVD+ G TP
Sbjct: 923 NAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962



 Score =  129 bits (324), Expect = 3e-29
 Identities = 132/493 (26%), Positives = 204/493 (41%), Gaps = 92/493 (18%)

Query: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL- 75
           N+  L  LL    D +++++ G++PL  AA   N + +  L+ +GA+ N  D    T L 
Sbjct: 417 NLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLH 476

Query: 76  ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGA-----NP 130
            +A+ +     +E LL+   N   RD  G+ A+ ++   G    ++L+ S          
Sbjct: 477 YAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMET 536

Query: 131 SVTGLYS-------VYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHL 183
           S T + S       + P+  AA  GH   + +L+Q+   ++  +  G TPL  AA KGH+
Sbjct: 537 SGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHV 596

Query: 184 ECVKHLLAMGAD-------------------------------------VDQEGANSMTA 206
           ECV  L+  GA                                      VD +  N  T 
Sbjct: 597 ECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTP 656

Query: 207 LIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPD 266
           L+++V  G+T  V  +L +  NV+  DK G TAL   +  GH E V  LL  G    + D
Sbjct: 657 LMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRD 716

Query: 267 RSGDTVLIGAVRGGHVEIVRALLQKYADIDIR--GQDNK--TALYWAVEKGNATMVRDIL 322
             G T +  +   GH+ ++ ALLQ  A +D      DN   TAL+WA   G+ T V  +L
Sbjct: 717 SRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLL 776

Query: 323 QCNP----------------------------DT------EICTKDGETPLIKATKMRNI 348
           +                               DT            G TPL  A    ++
Sbjct: 777 EQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHV 836

Query: 349 EVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPY 408
           E ++LLL   A+V++VD  G TPL +A         E+L+ +      L   +K   T  
Sbjct: 837 ECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSK--NTAL 894

Query: 409 NIDCS--HQKSIL 419
           ++ CS  H+ S L
Sbjct: 895 HLACSKGHETSAL 907



 Score =  125 bits (315), Expect = 3e-28
 Identities = 98/348 (28%), Positives = 159/348 (45%), Gaps = 6/348 (1%)

Query: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
           +L+ A   G    V  L+    ++  +D    T L  A Y G  +++ELL+  GA  +  
Sbjct: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70

Query: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
               + P+  A      + V +LL++ A VN  DK   TPL  AA    ++C + L+ + 
Sbjct: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130

Query: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
           ++V+       TAL  A   G+ + VK +L R  N+N  DK    A+  A+  GH E+V+
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190

Query: 254 DLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKG 313
            L+  G  V   D+   T L  A   G + +V+ LL    D++       T L+ A   G
Sbjct: 191 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250

Query: 314 NATMVRDILQCNPDTEICTKDGETPL-IKATKMRNIEVVELLLDKGAKVSAVDKKGDTPL 372
              +V +++ C        + G TPL   A        +ELL+  GA V+   K G TPL
Sbjct: 251 QDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310

Query: 373 HI-AIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSIL 419
           H+ A+ GR  +   ++    + G ++   +K G TP +I   +   +L
Sbjct: 311 HMTALHGRFSRSQTII----QSGAVIDCEDKNGNTPLHIAARYGHELL 354



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 33/114 (28%), Positives = 61/114 (53%), Gaps = 3/114 (2%)

Query: 302 NKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKV 361
           ++ +L  A+  G+   VR ++    D      +  TPL  A  + + E++ELL+  GA+V
Sbjct: 8   DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67

Query: 362 SAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQ 415
           +A D K  TPLH A+   S +  ++LL++  D   +   +K  +TP +I  +++
Sbjct: 68  NAKDSKWLTPLHRAVASCSEEAVQVLLKHSAD---VNARDKNWQTPLHIAAANK 118



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 56/211 (26%), Positives = 84/211 (39%), Gaps = 38/211 (18%)

Query: 16   ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
            +++  L+ LL     V+  +  G+TPLM+AAE G    V+ L+                 
Sbjct: 834  DHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVS---------------- 877

Query: 76   ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSV--- 132
             SAS E               L  +D    TAL  AC KG      L+L    + ++   
Sbjct: 878  -SASAE---------------LTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINA 921

Query: 133  TGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTP-LVWAARKGHLECVKHLLA 191
            T      P+  AA  G   +V  LL  GA V   D+ G TP L  A  K   +C+  +LA
Sbjct: 922  TNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILA 981

Query: 192  MGADVDQEGANSMTALIVAVKGGYTQSVKEI 222
                V    ++ +++L       YT + K +
Sbjct: 982  TMMPV--SSSSPLSSLTFNAINRYTNTSKTV 1010


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score =  153 bits (386), Expect = 2e-36
 Identities = 96/303 (31%), Positives = 166/303 (54%), Gaps = 2/303 (0%)

Query: 5   ISQSVINYVEEENIPALKALLEKCK--DVDERNECGQTPLMIAAEQGNLEIVKELIKNGA 62
           + +++I+ + ++N+P L+ LL      DV++ N+ G  PL+IAA  GN++I++ LIK G+
Sbjct: 344 VMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGS 403

Query: 63  NCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVEL 122
             +++D     A+  A++ GHV  ++ L +    L+ +D  G  AL  A   G  DV +L
Sbjct: 404 RIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQL 463

Query: 123 LLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGH 182
           L S G+NP++       P+  AA  G+  +   L + G  VN  ++ G TPL+ A+ +G+
Sbjct: 464 LCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGY 523

Query: 183 LECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMI 242
            + V+ L   GAD++    +   AL +AV+    + +K +L +   V+  D+ GNT L +
Sbjct: 524 HDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHV 583

Query: 243 ASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDN 302
           A K+G+  IV  L +A   ++I ++ G T L  A   G +++VR L    A ++    D 
Sbjct: 584 ACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDG 643

Query: 303 KTA 305
           KTA
Sbjct: 644 KTA 646



 Score =  132 bits (333), Expect = 2e-30
 Identities = 97/331 (29%), Positives = 156/331 (47%), Gaps = 6/331 (1%)

Query: 67  EDLDNWTALISASKEGHV----HIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVEL 122
           ED     A+I A  + +V    H++  L    VN  ++   G   L+ A   G   +++L
Sbjct: 340 EDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKH--GTPPLLIAAGCGNIQILQL 397

Query: 123 LLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGH 182
           L+  G+   V        + WAA  GH D +  L +N   ++  DK G   L  AAR GH
Sbjct: 398 LIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGH 457

Query: 183 LECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMI 242
            +  + L + G++ + +     T L  A   GY    K + +   NVN+ +++G T L+ 
Sbjct: 458 ADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLT 517

Query: 243 ASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDN 302
           AS  G+ +IV+ L + G  +N  D+ G   L  AVR   +E+++ LL +   +D + +  
Sbjct: 518 ASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHG 577

Query: 303 KTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVS 362
            T L+ A + GN  +V  + + N + +I  K G TPL  A     ++VV  L   GA V 
Sbjct: 578 NTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVE 637

Query: 363 AVDKKGDTPLHIAIRGRSRKLAELLLRNPKD 393
           A+   G T   +A   +   +A LL R  KD
Sbjct: 638 ALTTDGKTAEDLARSEQHEHVAGLLARLRKD 668



 Score = 44.7 bits (104), Expect = 8e-04
 Identities = 26/73 (35%), Positives = 40/73 (54%)

Query: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
           ++ N+P + AL E   ++D  N+ G+TPL +AA  G L++V+ L   GA+      D  T
Sbjct: 586 KDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKT 645

Query: 74  ALISASKEGHVHI 86
           A   A  E H H+
Sbjct: 646 AEDLARSEQHEHV 658


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  150 bits (379), Expect = 1e-35
 Identities = 109/375 (29%), Positives = 177/375 (47%)

Query: 13  VEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNW 72
           V + ++  ++ LL    DVD +   G TPL+IAA+    ++   L+ +GA+ N  D D W
Sbjct: 370 VAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGW 429

Query: 73  TALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSV 132
             L  A++ G       LL  G  ++ ++  GWT L  A      +V  LL+S  A+P++
Sbjct: 430 APLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNL 489

Query: 133 TGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAM 192
                  P+  AA  GH  +V LL   GA+++   +   TPL  A  +G +  ++HLL  
Sbjct: 490 HEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKS 549

Query: 193 GADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIV 252
           GA  D    +    L  A   G     K +L+   ++ L    G T L +A+ +GH EI+
Sbjct: 550 GAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEII 609

Query: 253 QDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEK 312
             L ++   +        T L  A R G   +V ALLQ  AD +   Q   T L+ AV++
Sbjct: 610 HLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQR 669

Query: 313 GNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPL 372
                V ++L+ + +     K G TP   A    N  ++++L++ GA++   D    TPL
Sbjct: 670 STFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPL 729

Query: 373 HIAIRGRSRKLAELL 387
            +A+R R + +   L
Sbjct: 730 QLALRSRKQGIMSFL 744



 Score =  148 bits (373), Expect = 5e-35
 Identities = 106/349 (30%), Positives = 163/349 (46%), Gaps = 1/349 (0%)

Query: 40  TPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEH 99
           TPL     QG++E V+ L+ +  + + +    +T L+ A+++    +   LL  G +   
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423

Query: 100 RDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQN 159
            D  GW  L +A   G      LLL HGA           P+  AA     ++  LL+  
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483

Query: 160 GAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSV 219
            A  N  +  G TPL  AA  GH+  VK L + GA++D +  N  T L +AV+ G  +++
Sbjct: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543

Query: 220 KEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRG 279
           + +LK     +  D+ G   L  A+  G   I + LL  G  + +P   G T L  A   
Sbjct: 544 QHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYK 603

Query: 280 GHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPL 339
           GH+EI+  L + +A++   G  N T L+ A   G   +V  +LQC  D     + G TPL
Sbjct: 604 GHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPL 663

Query: 340 IKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHI-AIRGRSRKLAELL 387
             A +      V  LL+  A V A +K G TP H+ A++G +  L  L+
Sbjct: 664 HLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLV 712



 Score =  113 bits (283), Expect = 1e-24
 Identities = 89/308 (28%), Positives = 141/308 (45%), Gaps = 9/308 (2%)

Query: 106 TALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNC 165
           T L +   +G  + V LLL+H  +          P++ AA     D+  LLL +GA  N 
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423

Query: 166 SDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKR 225
            D+ G  PL +AA+ G     + LL  GA VD +     T L +A +  +    + ++ R
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483

Query: 226 NPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIV 285
             + NL + +G T L +A+  GH  +V+ L   G  ++   R+  T L  AV  G V  +
Sbjct: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543

Query: 286 RALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKM 345
           + LL+  A  D   Q     L+ A  +G   + + +L+     E+ T  G TPL  A   
Sbjct: 544 QHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYK 603

Query: 346 RNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKA-- 403
            ++E++ LL +  A + A+     TPLH+A R     +   LL+   D      PN A  
Sbjct: 604 GHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGAD------PNAAEQ 657

Query: 404 -GETPYNI 410
            G TP ++
Sbjct: 658 SGWTPLHL 665



 Score = 95.9 bits (237), Expect = 3e-19
 Identities = 69/246 (28%), Positives = 115/246 (46%), Gaps = 3/246 (1%)

Query: 165 CSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILK 224
           C  +   TPL +   +G +E V+ LLA   DVD + A+  T L++A +         +L 
Sbjct: 357 CIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLA 416

Query: 225 RNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEI 284
              + N  D+DG   L  A++ G     + LLD G  V+  +R G T L  A +     +
Sbjct: 417 HGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENV 476

Query: 285 VRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATK 344
            R L+ + AD ++   + KT L+ A   G+ ++V+ +     + +   ++  TPL  A +
Sbjct: 477 ARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVE 536

Query: 345 MRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAG 404
              +  ++ LL  GA   A+D+ G  PLH A       + ++LLR    G  L  P   G
Sbjct: 537 RGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRY---GASLELPTHQG 593

Query: 405 ETPYNI 410
            TP ++
Sbjct: 594 WTPLHL 599



 Score = 95.9 bits (237), Expect = 3e-19
 Identities = 64/238 (26%), Positives = 115/238 (48%)

Query: 138 VYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVD 197
           V P+ +   +G  + V LLL +   V+C    G TPL+ AA+    +    LLA GAD +
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422

Query: 198 QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLD 257
           +   +    L  A + G   + + +L     V+  +++G T L +A++     + + L+ 
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS 482

Query: 258 AGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATM 317
                N+ +  G T L  A   GHV +V+ L  + A++D + ++ +T L+ AVE+G    
Sbjct: 483 RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRA 542

Query: 318 VRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
           ++ +L+     +   + G  PL  A       + ++LL  GA +     +G TPLH+A
Sbjct: 543 IQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600


>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
          Length = 301

 Score =  150 bits (379), Expect = 1e-35
 Identities = 97/255 (38%), Positives = 142/255 (55%), Gaps = 2/255 (0%)

Query: 17  NIPALKALLEKCK-DVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
           N+  LK LL   + DVD R+  G T LM+AA  G+++ V+EL+  GA+ NL+     TAL
Sbjct: 24  NLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTAL 83

Query: 76  ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135
             A+++GH  +V  L   G + E R   G TAL+ A   G   VVE LL HGAN      
Sbjct: 84  FFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANIHDQLY 143

Query: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
                +  AA  G+ D++ LLL +GAKVN   + GT PL  A++ GH E V+ +L  GAD
Sbjct: 144 DGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGAD 203

Query: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
            D    +  TAL+ A   GY   +KE+LK +P + +  K+G +AL  A   G+ + V  L
Sbjct: 204 RDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLSGNIKTVALL 262

Query: 256 LDAGTYVNIPDRSGD 270
           L+AG   ++ +++ +
Sbjct: 263 LEAGADPSLRNKANE 277



 Score =  144 bits (363), Expect = 8e-34
 Identities = 91/266 (34%), Positives = 142/266 (53%), Gaps = 5/266 (1%)

Query: 143 WAAGRGHADIVHLLLQNG-AKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGA 201
           WAA RG+  ++ LLL +G   V+C D +GTT L+ AA  GH++CV+ L+  GAD++ +  
Sbjct: 18  WAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRE 77

Query: 202 NSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTY 261
           +  TAL  A + G+   V+ +     +     KDG TAL+ AS+ GH ++V+ LL  G  
Sbjct: 78  SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGAN 137

Query: 262 VNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDI 321
           ++     G T L  A +GG+++++R LL   A ++   QD    L+ A + G++ +VR +
Sbjct: 138 IHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVM 197

Query: 322 LQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSR 381
           L    D +    DG T L+KA      +V++ LL K +    + K G + LH A+   + 
Sbjct: 198 LLRGADRDAARNDGTTALLKAANKGYNDVIKELL-KFSPTLGILKNGTSALHAAVLSGNI 256

Query: 382 KLAELLLRNPKDGRLLYRPNKAGETP 407
           K   LLL    D  L    NKA E P
Sbjct: 257 KTVALLLEAGADPSL---RNKANELP 279



 Score =  139 bits (351), Expect = 2e-32
 Identities = 92/278 (33%), Positives = 147/278 (52%), Gaps = 2/278 (0%)

Query: 107 ALMWACYKGRTDVVELLLSHG-ANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNC 165
           A  WA  +G   +++LLL+ G  +      +    ++ AA  GH D V  L+  GA +N 
Sbjct: 15  AAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINL 74

Query: 166 SDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKR 225
             + GTT L +AA++GH + V+ L   GA  +    +  TAL+ A + G+ Q V+ +LK 
Sbjct: 75  QRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKH 134

Query: 226 NPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIV 285
             N++    DG TAL +A++ G+ ++++ LL +G  VN P + G   L  A + GH E+V
Sbjct: 135 GANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVV 194

Query: 286 RALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKM 345
           R +L + AD D    D  TAL  A  KG   +++++L+ +P   I  K+G + L  A   
Sbjct: 195 RVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLS 253

Query: 346 RNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKL 383
            NI+ V LLL+ GA  S  +K  + P  +    R  +L
Sbjct: 254 GNIKTVALLLEAGADPSLRNKANELPAELTKNERILRL 291



 Score =  129 bits (325), Expect = 2e-29
 Identities = 88/281 (31%), Positives = 146/281 (51%), Gaps = 5/281 (1%)

Query: 78  ASKEGHVHIVEELLKCG-VNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
           A++ G++ +++ LL  G V+++ RD  G T LM A Y G  D V  L+  GA+ ++    
Sbjct: 19  AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78

Query: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
               + +AA +GH D+V  L   GA      K G T L+ A++ GH++ V+ LL  GA++
Sbjct: 79  GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGANI 138

Query: 197 DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLL 256
             +  +  TAL +A +GGY   ++ +L     VN   +DG   L IAS+ GH+E+V+ +L
Sbjct: 139 HDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVML 198

Query: 257 DAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNAT 316
             G   +     G T L+ A   G+ ++++ LL+    + I  ++  +AL+ AV  GN  
Sbjct: 199 LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-KNGTSALHAAVLSGNIK 257

Query: 317 MVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDK 357
            V  +L+   D  +  K  E P   A   +N  ++ LL  K
Sbjct: 258 TVALLLEAGADPSLRNKANELP---AELTKNERILRLLRSK 295


>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 2 [Homo sapiens]
          Length = 1390

 Score =  143 bits (361), Expect = 1e-33
 Identities = 121/403 (30%), Positives = 200/403 (49%), Gaps = 21/403 (5%)

Query: 17   NIPALKALLEKCKDVDERNEC-GQTPLM-IAAEQGNLEIVKELIKNGANCNLEDLDNWTA 74
            N+   + L+    +V+ R E     P++ + +  G+ E+V  L++ GA  +    +  TA
Sbjct: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963

Query: 75   LISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTG 134
            L  A+  GH+ +V  L K GV ++H D  G  AL+ +  +G  D+++ LL+   +P    
Sbjct: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1023

Query: 135  LYSV-------YPIIWAAGRGHADIVHLLL----QNGAKVNCSDK-YGTTPLVWAARKGH 182
              ++         +  AA  GH+ +V  LL    ++  +VN +D  +G T L  AA +G 
Sbjct: 1024 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1083

Query: 183  LECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMI 242
            LE  + LL  GA V +     +  L  A + G+ Q V+ +L+R  +VNL+DK G T LM+
Sbjct: 1084 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1143

Query: 243  ASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDN 302
            A+ EGH   V+ LL  G  ++  D+ G + L  A   GH  +V+ L+++ A ID   ++ 
Sbjct: 1144 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1203

Query: 303  KTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVS 362
            +T L  A   G+A  V  +++     E     G  PL +A   RN  VV  LL KGAK+ 
Sbjct: 1204 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL- 1262

Query: 363  AVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGE 405
                 G+    +A   +   L  LL +  ++G ++Y+  K  E
Sbjct: 1263 -----GNAAWAMA-TSKPDILIILLQKLMEEGNVMYKKGKMKE 1299


>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 1 [Homo sapiens]
          Length = 1861

 Score =  143 bits (361), Expect = 1e-33
 Identities = 121/403 (30%), Positives = 200/403 (49%), Gaps = 21/403 (5%)

Query: 17   NIPALKALLEKCKDVDERNEC-GQTPLM-IAAEQGNLEIVKELIKNGANCNLEDLDNWTA 74
            N+   + L+    +V+ R E     P++ + +  G+ E+V  L++ GA  +    +  TA
Sbjct: 912  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971

Query: 75   LISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTG 134
            L  A+  GH+ +V  L K GV ++H D  G  AL+ +  +G  D+++ LL+   +P    
Sbjct: 972  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1031

Query: 135  LYSV-------YPIIWAAGRGHADIVHLLL----QNGAKVNCSDK-YGTTPLVWAARKGH 182
              ++         +  AA  GH+ +V  LL    ++  +VN +D  +G T L  AA +G 
Sbjct: 1032 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1091

Query: 183  LECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMI 242
            LE  + LL  GA V +     +  L  A + G+ Q V+ +L+R  +VNL+DK G T LM+
Sbjct: 1092 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1151

Query: 243  ASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDN 302
            A+ EGH   V+ LL  G  ++  D+ G + L  A   GH  +V+ L+++ A ID   ++ 
Sbjct: 1152 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1211

Query: 303  KTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVS 362
            +T L  A   G+A  V  +++     E     G  PL +A   RN  VV  LL KGAK+ 
Sbjct: 1212 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL- 1270

Query: 363  AVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGE 405
                 G+    +A   +   L  LL +  ++G ++Y+  K  E
Sbjct: 1271 -----GNAAWAMA-TSKPDILIILLQKLMEEGNVMYKKGKMKE 1307


>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
           sapiens]
          Length = 587

 Score =  140 bits (353), Expect = 1e-32
 Identities = 106/365 (29%), Positives = 181/365 (49%), Gaps = 14/365 (3%)

Query: 9   VINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKN-GANCNLE 67
           +I  +++ +  ALK ++++ K++ E N+ G  PL  AA  G +  +K L +      +  
Sbjct: 61  LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120

Query: 68  DLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHG 127
            L   TA+  A+  GH+  +  LL+ G   +  +    T L  AC +   + V++L+ H 
Sbjct: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180

Query: 128 ANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVK 187
           A+ +         +  +  R   +++ +L+  GAKV   + YG TPL  AA+ G LE ++
Sbjct: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALR 240

Query: 188 HLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEG 247
            L   GAD++ + +++ +AL  A K  + + V+ +L +  + N T+KDG   L IASK+G
Sbjct: 241 FLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKG 300

Query: 248 HTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADID---------IR 298
           +  IVQ LL   +   I  RSG + L  A    H E++ ALL    D++         + 
Sbjct: 301 NYRIVQMLLPVTSRTRIR-RSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLY 359

Query: 299 GQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKG 358
                +ALY+AV   N      +LQ   D     +D  +PL+ A +   +  ++LLLD G
Sbjct: 360 EDRRSSALYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLDHG 416

Query: 359 AKVSA 363
           A + A
Sbjct: 417 ANIDA 421



 Score =  105 bits (262), Expect = 4e-22
 Identities = 90/329 (27%), Positives = 143/329 (43%), Gaps = 33/329 (10%)

Query: 75  LISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTG 134
           LI A K+G    ++ ++K G NL   +  GW  L  A Y G+   +++L           
Sbjct: 61  LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVL----------- 109

Query: 135 LYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGA 194
               YP           I    LQ             T +  A  +GHL+C+  LL  GA
Sbjct: 110 -QRAYP---------GTIDQRTLQE-----------ETAVYLATCRGHLDCLLSLLQAGA 148

Query: 195 DVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQD 254
           + D    +  T L  A +    ++VK +++ N + N     G TAL  +      E++Q 
Sbjct: 149 EPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQI 208

Query: 255 LLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGN 314
           L+  G  V   +  G T L  A + G +E +R L +  ADI+ +  DN +ALY A +  +
Sbjct: 209 LVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEH 268

Query: 315 ATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHI 374
             +V  +L    D     KDG  PL  A+K  N  +V++LL   ++ + + + G +PLH+
Sbjct: 269 EEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSR-TRIRRSGVSPLHL 327

Query: 375 AIRGRSRKLAELLLRNPKDGRLLYRPNKA 403
           A      ++ E LL    D      P +A
Sbjct: 328 AAERNHDEVLEALLSARFDVNTPLAPERA 356


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  140 bits (352), Expect = 1e-32
 Identities = 130/451 (28%), Positives = 195/451 (43%), Gaps = 64/451 (14%)

Query: 2   SVLISQSVINYVEEE------------NIPALKALLEKCKDVDERNECGQTPLMIAAEQG 49
           S+L  +  IN +++E            ++P L+ LL    +V+ ++    TPL  AA   
Sbjct: 26  SLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASR 85

Query: 50  NLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALM 109
           N +++  L+ + A+ N  D    T L  A+        E L     +L   D  G +AL 
Sbjct: 86  NEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALH 145

Query: 110 WACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKY 169
            A + G  + V LLL+ GA+ +V       P+ WAA  GH +++ LL+  GA + C D+ 
Sbjct: 146 HAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRK 205

Query: 170 GTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNV 229
           G   L  AA  G +E VK+LL MGA++D+  A   TAL +A   G      E++    NV
Sbjct: 206 GYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANV 265

Query: 230 NLTDKDGNTALMIA-----------------------SKEGHTEI-----------VQDL 255
           N  +  G T L +A                       SKEG + +            Q L
Sbjct: 266 NQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQIL 325

Query: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
           +  G+ ++  D+ G+T L  A R GH  ++  L+   AD   RG  +   L+ AV  G +
Sbjct: 326 IQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFS 385

Query: 316 TMVRDILQ----------------CNPDTEICTKD--GETPLIKATKMRNIEVVELLLDK 357
              R +L                  +   +I T D  G T L  A    N+E + LLL  
Sbjct: 386 DCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSS 445

Query: 358 GAKVSAVDKKGDTPLHIAIRGRSRKLAELLL 388
           GA +   DK G TPLH A    S + A  L+
Sbjct: 446 GADLRRRDKFGRTPLHYAAANGSYQCAVTLV 476



 Score =  140 bits (352), Expect = 1e-32
 Identities = 123/436 (28%), Positives = 197/436 (45%), Gaps = 47/436 (10%)

Query: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNW---TALIS 77
           L+ LL+   D   R+  G T +  AA  GN + ++ L++   NC LED+++    + L  
Sbjct: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNC-LEDVESTIPVSPLHL 591

Query: 78  ASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYS 137
           A+  GH   ++ L +  VNL+ RD  G TAL  A  +G T+ VE+L +HGA+  +     
Sbjct: 592 AAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKR 651

Query: 138 VY-PIIWAAGRGHADIVHLLLQNGAKVNCSD---KYGTTPLVWAARKGHLECVKHLLAMG 193
            + P+  AA  GH D +HLL+ +G + + +D    YG TPL+ A   GH++CV  LL  G
Sbjct: 652 KWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKG 711

Query: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
           +  D       TAL      G    +  +L  +  V   D  G T + +AS  GHT +++
Sbjct: 712 STADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLR 771

Query: 254 DLLDAGTYVNI----PDRSGDTVLIGAVRGGHVEIVRALLQ----KYAD----------- 294
            LL A    +      D SG + +  A   GH + +  LL+     Y +           
Sbjct: 772 TLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAV 831

Query: 295 -------------------IDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDG 335
                              ++ R    +T L+ A    N + +R +LQ   +       G
Sbjct: 832 INNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTG 891

Query: 336 ETPLIKATKMRNIEVVELLLDKG-AKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDG 394
            T L+ A +      VE LL +G A ++ +D+  +T LH+A      K A ++L   +D 
Sbjct: 892 RTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDL 951

Query: 395 RLLYRPNKAGETPYNI 410
            L+   N A + P +I
Sbjct: 952 GLINATNSALQMPLHI 967



 Score =  138 bits (347), Expect = 5e-32
 Identities = 104/377 (27%), Positives = 180/377 (47%), Gaps = 1/377 (0%)

Query: 1   MSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKN 60
           +S+     ++  +   ++  +++LL + ++++  ++  +TPL  AA  G++ I++ L+ +
Sbjct: 4   LSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMS 63

Query: 61  GANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVV 120
           GAN N +D    T L  A+   +  ++  LL    ++  RD    T L  A     T   
Sbjct: 64  GANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCA 123

Query: 121 ELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARK 180
           E L    ++ +V        +  A   GH + V+LLL  GA +N  DK    PL WAA  
Sbjct: 124 EALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFL 183

Query: 181 GHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTAL 240
           GHLE +K L+A GAD+  +       L  A   G  + VK +L+    ++  +  GNTAL
Sbjct: 184 GHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTAL 243

Query: 241 MIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVL-IGAVRGGHVEIVRALLQKYADIDIRG 299
            IA   G   +  +L++AG  VN P+  G T L + AV       +  L+   AD++ + 
Sbjct: 244 HIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQS 303

Query: 300 QDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGA 359
           ++ K+ L+ A   G  T  + ++Q   + +   K G TPL  A +  +  ++  L+  GA
Sbjct: 304 KEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGA 363

Query: 360 KVSAVDKKGDTPLHIAI 376
             +        PLH+A+
Sbjct: 364 DTARRGIHDMFPLHLAV 380



 Score =  126 bits (316), Expect = 2e-28
 Identities = 100/347 (28%), Positives = 166/347 (47%), Gaps = 6/347 (1%)

Query: 75  LISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTG 134
           L+ A     V  V  LL    N+   D    T L  A Y G   +++LLL  GAN +   
Sbjct: 12  LVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKD 71

Query: 135 LYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGA 194
              + P+  AA   +  ++ LLL + A VN  DK   TPL  AA     +C + L  + +
Sbjct: 72  TLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLS 131

Query: 195 DVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQD 254
            ++    +  +AL  AV  G+ ++V  +L +  ++N+ DK     L  A+  GH E+++ 
Sbjct: 132 SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKL 191

Query: 255 LLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGN 314
           L+  G  +   DR G  +L  A   G +E+V+ LL+  A+ID       TAL+ A   G 
Sbjct: 192 LVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQ 251

Query: 315 ATMVRDILQCNPDTEICTKDGETPL-IKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLH 373
             +  +++    +       G TPL + A        +ELL++ GA V+   K+G +PLH
Sbjct: 252 DAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLH 311

Query: 374 I-AIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSIL 419
           + AI GR  + +++L++N   G  +   +K G TP ++   +   +L
Sbjct: 312 MAAIHGRFTR-SQILIQN---GSEIDCADKFGNTPLHVAARYGHELL 354



 Score =  120 bits (302), Expect = 9e-27
 Identities = 98/356 (27%), Positives = 160/356 (44%), Gaps = 1/356 (0%)

Query: 39  QTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLE 98
           Q PL+ A    ++E V+ L+    N N+ D +  T L +A+  G V I++ LL  G N+ 
Sbjct: 9   QPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVN 68

Query: 99  HRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQ 158
            +D    T L  A       V+ LLL+H A+ +        P+  AA          L  
Sbjct: 69  AKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAP 128

Query: 159 NGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQS 218
             + +N +D+ G + L  A   GHLE V  LL  GA ++         L  A   G+ + 
Sbjct: 129 LLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEV 188

Query: 219 VKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVR 278
           +K ++ R  ++   D+ G   L  A+  G  E+V+ LL  G  ++ P+  G+T L  A  
Sbjct: 189 LKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACY 248

Query: 279 GGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCN-PDTEICTKDGET 337
            G   +   L+   A+++       T L+ A    N  +  ++L  N  D    +K+G++
Sbjct: 249 LGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKS 308

Query: 338 PLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKD 393
           PL  A         ++L+  G+++   DK G+TPLH+A R     L   L+ N  D
Sbjct: 309 PLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD 364



 Score =  116 bits (291), Expect = 2e-25
 Identities = 128/510 (25%), Positives = 209/510 (40%), Gaps = 96/510 (18%)

Query: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
           L+ L+    DV+ +++ G++PL +AA  G     + LI+NG+  +  D    T L  A++
Sbjct: 289 LELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAAR 348

Query: 81  EGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYP 140
            GH  ++  L+  G +   R +     L  A   G +D    LLS G   S+    S   
Sbjct: 349 YGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEH 408

Query: 141 IIWA------------------AGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGH 182
           ++ A                  A  G+ + ++LLL +GA +   DK+G TPL +AA  G 
Sbjct: 409 VLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGS 468

Query: 183 LECVKHLLAMGADVDQEGANSMTAL-IVAVKGGYTQS---------------VKE----- 221
            +C   L+  GA V++      + L   A    Y ++               +KE     
Sbjct: 469 YQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKE 528

Query: 222 -------ILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLI 274
                  +L    + +L D+ G TA+  A+  G+ + ++ LL+     N  +    T+ +
Sbjct: 529 AFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMS--FNCLEDVESTIPV 586

Query: 275 G----AVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVR----------- 319
                A   GH E ++ L +   ++D+R    +TAL+ A E+G+   V            
Sbjct: 587 SPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALI 646

Query: 320 -------------------DILQCNPD-------TEICTKDGETPLIKATKMRNIEVVEL 353
                              D L    D       T++    G+TPL+ A    +++ V L
Sbjct: 647 KERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHL 706

Query: 354 LLDKGAKVSAVDKKGDTPLHI-AIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI-- 410
           LL+KG+   A D +G T LH  A+ G    LA LL     D  +L R  K G TP ++  
Sbjct: 707 LLEKGSTADAADLRGRTALHRGAVTGCEDCLAALL---DHDAFVLCRDFK-GRTPIHLAS 762

Query: 411 DCSHQKSILTQIFGARHLSPTETDGDMLGY 440
            C H   + T +  A    P +   D  GY
Sbjct: 763 ACGHTAVLRTLLQAALSTDPLDAGVDYSGY 792



 Score =  115 bits (288), Expect = 4e-25
 Identities = 115/399 (28%), Positives = 168/399 (42%), Gaps = 48/399 (12%)

Query: 20  ALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLD-NWTALISA 78
           ALK L E   ++D R+  G+T L +A E+G+ E V+ L  +GA+  +++    WT L +A
Sbjct: 600 ALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAA 659

Query: 79  SKEGHVHIVEELLKCGVNLEHRDM---GGWTALMWACYKGRTDVVELLLSHGANP----- 130
           +  GH   +  L+  G   +  D+    G T LM A   G  D V LLL  G+       
Sbjct: 660 AASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADL 719

Query: 131 ---------SVTGLYSVY-------------------PIIWAAGRGHADIVHLLLQNGAK 162
                    +VTG                        PI  A+  GH  ++  LLQ    
Sbjct: 720 RGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALS 779

Query: 163 VNCSDK----YGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQS 218
            +  D      G +P+ WA+  GH +C++ LL        EG N  T L  AV      +
Sbjct: 780 TDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEG-NPFTPLHCAVINNQDST 838

Query: 219 VKEILKR--NPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGA 276
            + +L       VN  D  G T L  A+   +   ++ LL     VN  D +G T L+ A
Sbjct: 839 TEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTA 898

Query: 277 VRGGHVEIVRALLQK-YADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDG 335
              G    V  LL +  AD+ +  ++  TAL+ A  KG+      IL    D  +     
Sbjct: 899 AENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATN 958

Query: 336 ---ETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTP 371
              + PL  A +     VV+ LL  GA V AVD++G TP
Sbjct: 959 SALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997



 Score =  112 bits (279), Expect = 4e-24
 Identities = 93/316 (29%), Positives = 148/316 (46%), Gaps = 4/316 (1%)

Query: 108 LMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSD 167
           L+ A +    + V  LLS   N +V       P+  AA  G   I+ LLL +GA VN  D
Sbjct: 12  LVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKD 71

Query: 168 KYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNP 227
               TPL  AA   + + +  LLA  ADV+       T L VA     T+  + +     
Sbjct: 72  TLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLS 131

Query: 228 NVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRA 287
           ++N+ D+ G +AL  A   GH E V  LL+ G  +N+ D+     L  A   GH+E+++ 
Sbjct: 132 SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKL 191

Query: 288 LLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRN 347
           L+ + AD+  + +     L+ A   G   +V+ +L+   + +     G T L  A  +  
Sbjct: 192 LVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQ 251

Query: 348 IEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLA-ELLLRNPKDGRLLYRPNKAGET 406
             V   L++ GA V+  + KG TPLH+A    +  L  ELL+ N  D   +   +K G++
Sbjct: 252 DAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGAD---VNYQSKEGKS 308

Query: 407 PYNIDCSHQKSILTQI 422
           P ++   H +   +QI
Sbjct: 309 PLHMAAIHGRFTRSQI 324



 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 78/272 (28%), Positives = 128/272 (47%), Gaps = 5/272 (1%)

Query: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199
           P++ A      + V  LL     +N  D+   TPL  AA  G +  ++ LL  GA+V+ +
Sbjct: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70

Query: 200 GANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAG 259
               +T L  A      + +  +L  + +VN  DK   T L +A+    T+  + L    
Sbjct: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130

Query: 260 TYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVR 319
           + +N+ DRSG + L  AV  GH+E V  LL K A +++  +  +  L+WA   G+  +++
Sbjct: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLK 190

Query: 320 DILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA-IRG 378
            ++    D     + G   L  A     IEVV+ LL  GA++   +  G+T LHIA   G
Sbjct: 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLG 250

Query: 379 RSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 410
           +     EL+      G  + +PN  G TP ++
Sbjct: 251 QDAVAIELV----NAGANVNQPNDKGFTPLHV 278



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 51/180 (28%), Positives = 80/180 (44%), Gaps = 36/180 (20%)

Query: 16   ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNG-ANCNLEDLDNWTA 74
            +N+  L+ LL+   +V+  +  G+T LM AAE G    V+ L+  G A+  + D +  TA
Sbjct: 869  DNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTA 928

Query: 75   LISASKEGHVHIVEELLKCGVNL--EHRDMGGWTALMWACYKGRTDVVELLLSHGANPSV 132
            L  A  +GH        KC + +  E +D+G                    L +  N ++
Sbjct: 929  LHLACSKGHE-------KCALMILAETQDLG--------------------LINATNSAL 961

Query: 133  TGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTP-LVWAARKGHLECVKHLLA 191
                   P+  AA  G A +V  LL +GA V   D+ G TP L  A  K   +C+  +L+
Sbjct: 962  Q-----MPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILS 1016


>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 2 [Homo sapiens]
          Length = 1990

 Score =  140 bits (352), Expect = 1e-32
 Identities = 116/369 (31%), Positives = 166/369 (44%), Gaps = 41/369 (11%)

Query: 3    VLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGA 62
            +L  QS + Y E      +  LLE   +VD  +E G TPL  AA  G L IV  L K  A
Sbjct: 888  ILCVQSHLGYTE-----MVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRA 942

Query: 63   NCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVEL 122
              +  D +   AL+ A+  GH+ +V+ L++C   +  +  G +                 
Sbjct: 943  KVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKK--------------- 987

Query: 123  LLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQ---------NGAKVNCSDK-YGTT 172
              SH    +         +I AA  G+ +IV  LL            A++N  D  +G T
Sbjct: 988  --SHAIQQA---------LIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGET 1036

Query: 173  PLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLT 232
             L  AA +G LE  + LL  GA V Q        L   V+ G+ Q V  +L    +VN+ 
Sbjct: 1037 ALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMA 1096

Query: 233  DKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKY 292
            DK G T LM+A+ EGH   V  LL  G  + + D+ G T L  A   GH+ +VR+L+   
Sbjct: 1097 DKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNG 1156

Query: 293  ADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVE 352
            A  D   ++ +T L  A   G+A +V+ ++      E     G  PL +A   RN  VV 
Sbjct: 1157 AATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVV 1216

Query: 353  LLLDKGAKV 361
             LL KGAK+
Sbjct: 1217 TLLKKGAKI 1225



 Score =  131 bits (330), Expect = 5e-30
 Identities = 110/359 (30%), Positives = 168/359 (46%), Gaps = 19/359 (5%)

Query: 50   NLEIVKELIKNGANCNL--EDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTA 107
            N+++ + LI  GAN N   E L+N   L   S  G+  +V  LL+ G N++     G T 
Sbjct: 862  NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921

Query: 108  LMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQ-----NGAK 162
            L +A   G   +V LL    A            ++ AA RGH ++V  L+Q      G +
Sbjct: 922  LGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981

Query: 163  VNCSDKYGTTP--LVWAARKGHLECVKHLLAMGA----DVDQEGANSM------TALIVA 210
                 K       L+ AA  G+ E V +LL +      +V++   NS       TAL  A
Sbjct: 982  QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAA 1041

Query: 211  VKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGD 270
               G  +  + +L++   V   ++ G   L    ++GH +IV  LL  G  VN+ D+ G 
Sbjct: 1042 AGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGR 1101

Query: 271  TVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEI 330
            T L+ A   GH+  V  LL + A I +  ++  TAL WA  KG+ ++VR ++     T+ 
Sbjct: 1102 TPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDH 1161

Query: 331  CTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLR 389
              K+G TPL  A    + EVV+ L+D GA +  VD  G  PL  A+  R+  +   LL+
Sbjct: 1162 ADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLK 1220



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 76/268 (28%), Positives = 116/268 (43%), Gaps = 41/268 (15%)

Query: 152  IVHLLLQNGAKVNC-SDKYGTTPLVWA-ARKGHLECVKHLLAMGADVDQEGANSMTALIV 209
            +  LL+  GA +N  ++     P++   +  G+ E V  LL  GA+VD    + +T L  
Sbjct: 865  VSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGY 924

Query: 210  AVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLD-----AGTYVNI 264
            A   GY   V  + K+   V+  DK+G  AL+ A+  GH E+V+ L+      AG    +
Sbjct: 925  AAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGV 984

Query: 265  PDRSG--DTVLIGAVRGGHVEIVRALL---QKYADIDIRGQDNKTALYWAVEKGNATMVR 319
              +S      LI A   G+ EIV  LL   +K  +   R Q N     W           
Sbjct: 985  FKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLW----------- 1033

Query: 320  DILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGR 379
                           GET L  A     +EV  LLL++GA V+  +++G  PL   +R  
Sbjct: 1034 ---------------GETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQG 1078

Query: 380  SRKLAELLLRNPKDGRLLYRPNKAGETP 407
              ++ +LLL +  D  +    +K G TP
Sbjct: 1079 HWQIVDLLLTHGADVNM---ADKQGRTP 1103



 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 42/143 (29%), Positives = 64/143 (44%), Gaps = 8/143 (5%)

Query: 15   EENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTA 74
            E ++  +  LL +   +   ++ G T L  A  +G+L +V+ L+ NGA  +  D +  T 
Sbjct: 1110 EGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTP 1169

Query: 75   LISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTG 134
            L  A+  G   +V+ L+  G  +EH D  G   L  A     T VV  LL  GA      
Sbjct: 1170 LDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA------ 1223

Query: 135  LYSVYPIIWAAGRGHADIVHLLL 157
               + P  WA      DI+ +LL
Sbjct: 1224 --KIGPATWAMATSKPDIMIILL 1244


>gi|34304381 inversin isoform a [Homo sapiens]
          Length = 1065

 Score =  139 bits (351), Expect = 2e-32
 Identities = 99/329 (30%), Positives = 166/329 (50%), Gaps = 8/329 (2%)

Query: 38  GQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNW--TALISASKEGHVHIVEELLKCGV 95
           G+TPL  A   GN+ +V +++ +  +CN+   DN   T L  A+  GH  IV  LL+   
Sbjct: 221 GRTPLHFAVADGNVTVV-DVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNK 279

Query: 96  N-LEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVH 154
           +     D  G T L +A      + V++ L H +    + L      +WAAG+G  D++ 
Sbjct: 280 SGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLR 339

Query: 155 --LLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVK 212
             L L++   +N +DKYG T L  AA  GH+  VK LL   A VD       T L  A +
Sbjct: 340 TMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACE 399

Query: 213 GGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTV 272
            G+   ++ ++K    V+L D+DG++ L  A+  G+ ++ Q L++     N+ D +G T 
Sbjct: 400 MGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTP 459

Query: 273 LIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ--CNPDTEI 330
           L  A  GG++  +  L++  AD +I+ ++ +TAL+W+   G    ++ +L     P+   
Sbjct: 460 LQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQME 519

Query: 331 CTKDGETPLIKATKMRNIEVVELLLDKGA 359
             ++  TPL  A      EV++ +L+ GA
Sbjct: 520 NNEERYTPLDYALLGERHEVIQFMLEHGA 548



 Score =  139 bits (350), Expect = 2e-32
 Identities = 113/370 (30%), Positives = 180/370 (48%), Gaps = 12/370 (3%)

Query: 30  DVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKE---GHVHI 86
           +VD +++  QT L  +A   N E VK LIK+ +N  + D++    L  A+       VH 
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHT 200

Query: 87  VEELLKCGVN---LEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVY--PI 141
           V  +L        L  +D  G T L +A   G   VV++L S+  + ++T   +++  P+
Sbjct: 201 VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY-ESCNITSYDNLFRTPL 259

Query: 142 IWAAGRGHADIVHLLLQ-NGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEG 200
            WAA  GHA IVHLLL+ N +    SD  G TPL +AA+    E VK  L   +  D   
Sbjct: 260 HWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSD 319

Query: 201 ANSMTALIVAVKGGYTQSVKEIL--KRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDA 258
               T+ + A   G    ++ +L  K + ++N+ DK G TAL  A+  GH   V+ LL+ 
Sbjct: 320 LEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLEN 379

Query: 259 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 318
              V+  D    T L  A   GH ++++ L++  A +D+  QD  + L+WA   GNA + 
Sbjct: 380 NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVC 439

Query: 319 RDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRG 378
           + +++   +  +    G TPL  A     I  + +L++  A  +  DK+G T LH +   
Sbjct: 440 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNN 499

Query: 379 RSRKLAELLL 388
                 +LLL
Sbjct: 500 GYLDAIKLLL 509



 Score =  132 bits (331), Expect = 4e-30
 Identities = 109/404 (26%), Positives = 188/404 (46%), Gaps = 15/404 (3%)

Query: 16  ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
           + +    ALL+   DV++ +   +T L +AA++GN   +K L+   AN   +DL+  T L
Sbjct: 59  DRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPL 118

Query: 76  ISASKEGHVHIVEELLK--CGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
              ++      +  LLK      ++ +D    TAL W+ Y    + V+LL+ H +N  + 
Sbjct: 119 HLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIP 178

Query: 134 GLYSVYPIIWAAGRGHADIVHLL------LQNGAKVNCSDKYGTTPLVWAARKGHLECVK 187
            +    P+ WAA       VH +          + +N  D  G TPL +A   G++  V 
Sbjct: 179 DVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVD 238

Query: 188 HLLAM-GADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASK 245
            L +    ++        T L  A   G+ Q V  +L+RN +  + +D  G T L  A++
Sbjct: 239 VLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQ 298

Query: 246 EGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQD--NK 303
               E V+  L   +  +  D  G T  + A   G  +++R +L   +DIDI   D    
Sbjct: 299 SNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGG 358

Query: 304 TALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSA 363
           TAL+ A   G+ + V+ +L+ N   +       TPL +A +M + +V++ L+  GA+V  
Sbjct: 359 TALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDL 418

Query: 364 VDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETP 407
           VD+ G + LH A  G +  + ++L+ N  +  +    + AG TP
Sbjct: 419 VDQDGHSLLHWAALGGNADVCQILIENKINPNV---QDYAGRTP 459



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 54/169 (31%), Positives = 89/169 (52%)

Query: 30  DVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEE 89
           D++  ++ G T L  AA  G++  VK L++N A  +  D+   T L  A + GH  +++ 
Sbjct: 349 DINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQT 408

Query: 90  LLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGH 149
           L+K G  ++  D  G + L WA   G  DV ++L+ +  NP+V       P+  AA  G+
Sbjct: 409 LIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 468

Query: 150 ADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQ 198
            + + +L++N A  N  DK G T L W+   G+L+ +K LL   A  +Q
Sbjct: 469 INCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQ 517



 Score = 88.2 bits (217), Expect = 6e-17
 Identities = 99/392 (25%), Positives = 157/392 (40%), Gaps = 48/392 (12%)

Query: 45  AAEQGNLEIVKELIK-NGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMG 103
           AA  G+   ++ LI  N A  + ED    T L+       +   + LLK G ++   D  
Sbjct: 21  AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80

Query: 104 GWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYP----------------------- 140
             TAL  A  KG    ++LLL+  AN     L  + P                       
Sbjct: 81  QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140

Query: 141 ------------IIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGH------ 182
                       + W+A   + + V LL+++ + +   D  G  PL WAA          
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHT 200

Query: 183 LECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDG--NTAL 240
           + C+       + ++ +     T L  AV  G   +V ++L    + N+T  D    T L
Sbjct: 201 VRCILDAAPTESLLNWQDYEGRTPLHFAVADG-NVTVVDVLTSYESCNITSYDNLFRTPL 259

Query: 241 MIASKEGHTEIVQDLLDAGTYVNIP-DRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRG 299
             A+  GH +IV  LL+      IP D  G T L  A +    E V+  L+  +  D   
Sbjct: 260 HWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSD 319

Query: 300 QDNKTALYWAVEKGNATMVRDILQCNPDTEI--CTKDGETPLIKATKMRNIEVVELLLDK 357
            + +T+  WA  KG+  ++R +L    D +I    K G T L  A    ++  V+LLL+ 
Sbjct: 320 LEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLEN 379

Query: 358 GAKVSAVDKKGDTPLHIAIRGRSRKLAELLLR 389
            A+V A D    TPL  A     + + + L++
Sbjct: 380 NAQVDATDVMKHTPLFRACEMGHKDVIQTLIK 411



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 78/294 (26%), Positives = 134/294 (45%), Gaps = 13/294 (4%)

Query: 155 LLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGG 214
           L++ N A  +  D++G TPL++      L+C   LL  GADV++   +  TAL +A + G
Sbjct: 33  LIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKG 92

Query: 215 YTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLD--AGTYVNIPDRSGDTV 272
             + +K +L R  N    D +  T L + ++    + +  LL   A   V+  D++  T 
Sbjct: 93  NYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTA 152

Query: 273 LIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNAT---MVRDILQCNPDTE 329
           L  +    + E V+ L++  ++I I   + K  L+WA    + +    VR IL   P   
Sbjct: 153 LHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTES 212

Query: 330 ICT---KDGETPLIKATKMRNIEVVELLLD-KGAKVSAVDKKGDTPLHIAIRGRSRKLAE 385
           +      +G TPL  A    N+ VV++L   +   +++ D    TPLH A      ++  
Sbjct: 213 LLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVH 272

Query: 386 LLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLG 439
           LLL   K G +    +  G TP +       +   ++F  +H S  + D D+ G
Sbjct: 273 LLLERNKSGTI--PSDSQGATPLHYAAQSNFAETVKVF-LKHPS-VKDDSDLEG 322


>gi|34304379 inversin isoform b [Homo sapiens]
          Length = 895

 Score =  139 bits (351), Expect = 2e-32
 Identities = 99/329 (30%), Positives = 166/329 (50%), Gaps = 8/329 (2%)

Query: 38  GQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNW--TALISASKEGHVHIVEELLKCGV 95
           G+TPL  A   GN+ +V +++ +  +CN+   DN   T L  A+  GH  IV  LL+   
Sbjct: 221 GRTPLHFAVADGNVTVV-DVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNK 279

Query: 96  N-LEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVH 154
           +     D  G T L +A      + V++ L H +    + L      +WAAG+G  D++ 
Sbjct: 280 SGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLR 339

Query: 155 --LLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVK 212
             L L++   +N +DKYG T L  AA  GH+  VK LL   A VD       T L  A +
Sbjct: 340 TMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACE 399

Query: 213 GGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTV 272
            G+   ++ ++K    V+L D+DG++ L  A+  G+ ++ Q L++     N+ D +G T 
Sbjct: 400 MGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTP 459

Query: 273 LIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ--CNPDTEI 330
           L  A  GG++  +  L++  AD +I+ ++ +TAL+W+   G    ++ +L     P+   
Sbjct: 460 LQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQME 519

Query: 331 CTKDGETPLIKATKMRNIEVVELLLDKGA 359
             ++  TPL  A      EV++ +L+ GA
Sbjct: 520 NNEERYTPLDYALLGERHEVIQFMLEHGA 548



 Score =  139 bits (350), Expect = 2e-32
 Identities = 113/370 (30%), Positives = 180/370 (48%), Gaps = 12/370 (3%)

Query: 30  DVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKE---GHVHI 86
           +VD +++  QT L  +A   N E VK LIK+ +N  + D++    L  A+       VH 
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHT 200

Query: 87  VEELLKCGVN---LEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVY--PI 141
           V  +L        L  +D  G T L +A   G   VV++L S+  + ++T   +++  P+
Sbjct: 201 VRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSY-ESCNITSYDNLFRTPL 259

Query: 142 IWAAGRGHADIVHLLLQ-NGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEG 200
            WAA  GHA IVHLLL+ N +    SD  G TPL +AA+    E VK  L   +  D   
Sbjct: 260 HWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSD 319

Query: 201 ANSMTALIVAVKGGYTQSVKEIL--KRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDA 258
               T+ + A   G    ++ +L  K + ++N+ DK G TAL  A+  GH   V+ LL+ 
Sbjct: 320 LEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLEN 379

Query: 259 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 318
              V+  D    T L  A   GH ++++ L++  A +D+  QD  + L+WA   GNA + 
Sbjct: 380 NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVC 439

Query: 319 RDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRG 378
           + +++   +  +    G TPL  A     I  + +L++  A  +  DK+G T LH +   
Sbjct: 440 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNN 499

Query: 379 RSRKLAELLL 388
                 +LLL
Sbjct: 500 GYLDAIKLLL 509



 Score =  132 bits (331), Expect = 4e-30
 Identities = 109/404 (26%), Positives = 188/404 (46%), Gaps = 15/404 (3%)

Query: 16  ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
           + +    ALL+   DV++ +   +T L +AA++GN   +K L+   AN   +DL+  T L
Sbjct: 59  DRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPL 118

Query: 76  ISASKEGHVHIVEELLK--CGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
              ++      +  LLK      ++ +D    TAL W+ Y    + V+LL+ H +N  + 
Sbjct: 119 HLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIP 178

Query: 134 GLYSVYPIIWAAGRGHADIVHLL------LQNGAKVNCSDKYGTTPLVWAARKGHLECVK 187
            +    P+ WAA       VH +          + +N  D  G TPL +A   G++  V 
Sbjct: 179 DVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVD 238

Query: 188 HLLAM-GADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASK 245
            L +    ++        T L  A   G+ Q V  +L+RN +  + +D  G T L  A++
Sbjct: 239 VLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQ 298

Query: 246 EGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQD--NK 303
               E V+  L   +  +  D  G T  + A   G  +++R +L   +DIDI   D    
Sbjct: 299 SNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGG 358

Query: 304 TALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSA 363
           TAL+ A   G+ + V+ +L+ N   +       TPL +A +M + +V++ L+  GA+V  
Sbjct: 359 TALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDL 418

Query: 364 VDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETP 407
           VD+ G + LH A  G +  + ++L+ N  +  +    + AG TP
Sbjct: 419 VDQDGHSLLHWAALGGNADVCQILIENKINPNV---QDYAGRTP 459



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 54/169 (31%), Positives = 89/169 (52%)

Query: 30  DVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEE 89
           D++  ++ G T L  AA  G++  VK L++N A  +  D+   T L  A + GH  +++ 
Sbjct: 349 DINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQT 408

Query: 90  LLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGH 149
           L+K G  ++  D  G + L WA   G  DV ++L+ +  NP+V       P+  AA  G+
Sbjct: 409 LIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 468

Query: 150 ADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQ 198
            + + +L++N A  N  DK G T L W+   G+L+ +K LL   A  +Q
Sbjct: 469 INCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQ 517



 Score = 88.2 bits (217), Expect = 6e-17
 Identities = 99/392 (25%), Positives = 157/392 (40%), Gaps = 48/392 (12%)

Query: 45  AAEQGNLEIVKELIK-NGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMG 103
           AA  G+   ++ LI  N A  + ED    T L+       +   + LLK G ++   D  
Sbjct: 21  AAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80

Query: 104 GWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYP----------------------- 140
             TAL  A  KG    ++LLL+  AN     L  + P                       
Sbjct: 81  QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140

Query: 141 ------------IIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGH------ 182
                       + W+A   + + V LL+++ + +   D  G  PL WAA          
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHT 200

Query: 183 LECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDG--NTAL 240
           + C+       + ++ +     T L  AV  G   +V ++L    + N+T  D    T L
Sbjct: 201 VRCILDAAPTESLLNWQDYEGRTPLHFAVADG-NVTVVDVLTSYESCNITSYDNLFRTPL 259

Query: 241 MIASKEGHTEIVQDLLDAGTYVNIP-DRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRG 299
             A+  GH +IV  LL+      IP D  G T L  A +    E V+  L+  +  D   
Sbjct: 260 HWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSD 319

Query: 300 QDNKTALYWAVEKGNATMVRDILQCNPDTEI--CTKDGETPLIKATKMRNIEVVELLLDK 357
            + +T+  WA  KG+  ++R +L    D +I    K G T L  A    ++  V+LLL+ 
Sbjct: 320 LEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLEN 379

Query: 358 GAKVSAVDKKGDTPLHIAIRGRSRKLAELLLR 389
            A+V A D    TPL  A     + + + L++
Sbjct: 380 NAQVDATDVMKHTPLFRACEMGHKDVIQTLIK 411



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 78/294 (26%), Positives = 134/294 (45%), Gaps = 13/294 (4%)

Query: 155 LLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGG 214
           L++ N A  +  D++G TPL++      L+C   LL  GADV++   +  TAL +A + G
Sbjct: 33  LIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKG 92

Query: 215 YTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLD--AGTYVNIPDRSGDTV 272
             + +K +L R  N    D +  T L + ++    + +  LL   A   V+  D++  T 
Sbjct: 93  NYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTA 152

Query: 273 LIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNAT---MVRDILQCNPDTE 329
           L  +    + E V+ L++  ++I I   + K  L+WA    + +    VR IL   P   
Sbjct: 153 LHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTES 212

Query: 330 ICT---KDGETPLIKATKMRNIEVVELLLD-KGAKVSAVDKKGDTPLHIAIRGRSRKLAE 385
           +      +G TPL  A    N+ VV++L   +   +++ D    TPLH A      ++  
Sbjct: 213 LLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVH 272

Query: 386 LLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLG 439
           LLL   K G +    +  G TP +       +   ++F  +H S  + D D+ G
Sbjct: 273 LLLERNKSGTI--PSDSQGATPLHYAAQSNFAETVKVF-LKHPS-VKDDSDLEG 322


>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
           sapiens]
          Length = 522

 Score =  139 bits (349), Expect = 3e-32
 Identities = 94/326 (28%), Positives = 163/326 (50%), Gaps = 12/326 (3%)

Query: 75  LISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSH-------- 126
           L  A+++ +V  ++EL+   VN   R+  G  AL WA   G    V LLL H        
Sbjct: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78

Query: 127 --GANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLE 184
             GA       + +  ++ +A  GH  I+ +L+ +GAK++C  K G T L  AA+KGH+ 
Sbjct: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138

Query: 185 CVKHLLAMGADVDQEGANSM--TALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMI 242
            +  ++    DV  +  + +  TA   A + G   ++  ++    + N+ DK+GNTAL +
Sbjct: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198

Query: 243 ASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDN 302
           A+  GH  ++Q L+D G  +   +  G T L  A  G H + V+ LL+  + ++   Q N
Sbjct: 199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKN 258

Query: 303 KTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVS 362
            + L++A   G+  + R ++       +    G +PL  A +     +V LL++  + V+
Sbjct: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318

Query: 363 AVDKKGDTPLHIAIRGRSRKLAELLL 388
           AVD +  TPLH+A     + +A++LL
Sbjct: 319 AVDNRQQTPLHLAAEHAWQDIADMLL 344



 Score =  116 bits (291), Expect = 2e-25
 Identities = 86/353 (24%), Positives = 164/353 (46%), Gaps = 12/353 (3%)

Query: 15  EENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDN--- 71
           + N+  ++ L+ +  +   RN  G+  L  AA  G+ + V+ L+++ A  + ED      
Sbjct: 25  QNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALT 84

Query: 72  -------WTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLL 124
                    AL+ ++  GH+ I++ L+  G  +      G T L  A  KG   V+  ++
Sbjct: 85  EARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIM 144

Query: 125 SHGANPSVTGLYSVYPIIW--AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGH 182
               + ++  +  +    +  AA  G  D +  L+ +G   N  DK G T L  AA +GH
Sbjct: 145 EDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGH 204

Query: 183 LECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMI 242
           +  ++ L+ +G D++++ A  +TAL  A  G +   V+ +L+    VN   +   + L  
Sbjct: 205 MAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHY 264

Query: 243 ASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDN 302
           A+  G  ++ + L+ AG   N+ D  G + L  AVR     +VR L+   +D++      
Sbjct: 265 AALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQ 324

Query: 303 KTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLL 355
           +T L+ A E     +   +L    D  +  K G+T L  A +  ++ +V++++
Sbjct: 325 QTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377



 Score =  108 bits (271), Expect = 4e-23
 Identities = 71/250 (28%), Positives = 126/250 (50%), Gaps = 2/250 (0%)

Query: 14  EEENIPALKALLEKCKDV--DERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDN 71
           ++ ++P L  ++E  +DV  D  ++ G+T    AAE G L+ +  L+ +G + N++D + 
Sbjct: 133 QKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEG 192

Query: 72  WTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPS 131
            TAL  A+  GH+ +++ L+  G++LE ++  G TAL  A      D V+LLL  G+  +
Sbjct: 193 NTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVN 252

Query: 132 VTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLA 191
                ++  + +AA  G  D+  +L+  G   N  D  G +PL  A R      V+ L+ 
Sbjct: 253 ALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLIN 312

Query: 192 MGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEI 251
             +DV+       T L +A +  +      +L    ++NL DK G TAL +A +  H  +
Sbjct: 313 SDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSL 372

Query: 252 VQDLLDAGTY 261
           V  ++ A  +
Sbjct: 373 VDMIIKADRF 382



 Score =  107 bits (268), Expect = 8e-23
 Identities = 86/318 (27%), Positives = 150/318 (47%), Gaps = 12/318 (3%)

Query: 20  ALKALLEKCKDVDERNECG----------QTPLMIAAEQGNLEIVKELIKNGANCNLEDL 69
           A++ LLE    VDE +  G             L+++A  G+L I++ L+ +GA  + E  
Sbjct: 63  AVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESK 122

Query: 70  DNWTALISASKEGHVHIVEELLKC--GVNLEHRDMGGWTALMWACYKGRTDVVELLLSHG 127
           D  T L  A+++GHV ++  +++    V L+H D  G TA   A   G+ D ++ L+  G
Sbjct: 123 DGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSG 182

Query: 128 ANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVK 187
            + +V        +  AAGRGH  ++  L+  G  +   +  G T L  AA   H +CV+
Sbjct: 183 CDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQ 242

Query: 188 HLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEG 247
            LL  G+ V+     +++ L  A   G     + ++      N+ D  G + L +A +  
Sbjct: 243 LLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHN 302

Query: 248 HTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALY 307
              +V+ L+++ + VN  D    T L  A      +I   LL    D+++R +  KTAL 
Sbjct: 303 FPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALA 362

Query: 308 WAVEKGNATMVRDILQCN 325
            AV   + ++V  I++ +
Sbjct: 363 VAVRSNHVSLVDMIIKAD 380


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.133    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,442,288
Number of Sequences: 37866
Number of extensions: 3352622
Number of successful extensions: 18839
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 346
Number of HSP's successfully gapped in prelim test: 220
Number of HSP's that attempted gapping in prelim test: 11709
Number of HSP's gapped (non-prelim): 3798
length of query: 1771
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1654
effective length of database: 13,817,196
effective search space: 22853642184
effective search space used: 22853642184
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.