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Search of human proteins with 54633319
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|54633319 PDZ domain-containing guanine nucleotide exchange
factor I [Homo sapiens]
(1601 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 3198 0.0
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens] 1769 0.0
gi|239752520 PREDICTED: similar to Rap guanine nucleotide exchan... 1181 0.0
gi|239753937 PREDICTED: similar to hCG2036828 [Homo sapiens] 172 2e-42
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 166 1e-40
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 166 1e-40
gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Hom... 160 1e-38
gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ... 146 1e-34
gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [... 146 1e-34
gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a ... 146 1e-34
gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [... 145 3e-34
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 99 3e-20
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 99 3e-20
gi|40255197 RasGEF domain family, member 1C [Homo sapiens] 94 8e-19
gi|117168263 RasGEF domain family, member 1A [Homo sapiens] 94 1e-18
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 92 4e-18
gi|22749129 RasGEF domain family, member 1B [Homo sapiens] 91 7e-18
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 89 4e-17
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 89 4e-17
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 89 4e-17
gi|15529996 son of sevenless homolog 1 [Homo sapiens] 85 5e-16
gi|154689780 son of sevenless homolog 2 [Homo sapiens] 80 1e-14
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 79 5e-14
gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo sapi... 78 6e-14
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 77 2e-13
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 77 2e-13
gi|93102367 ral guanine nucleotide dissociation stimulator-like ... 76 3e-13
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ... 75 5e-13
gi|24307909 ral guanine nucleotide dissociation stimulator isofo... 75 7e-13
gi|108796058 ral guanine nucleotide dissociation stimulator isof... 75 7e-13
>gi|54633319 PDZ domain-containing guanine nucleotide exchange factor
I [Homo sapiens]
Length = 1601
Score = 3198 bits (8291), Expect = 0.0
Identities = 1601/1601 (100%), Positives = 1601/1601 (100%)
Query: 1 MNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSG 60
MNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSG
Sbjct: 1 MNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSG 60
Query: 61 NQVLFCSETIARCWYILLSGSVLVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVEN 120
NQVLFCSETIARCWYILLSGSVLVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVEN
Sbjct: 61 NQVLFCSETIARCWYILLSGSVLVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVEN 120
Query: 121 AKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSLPADLTKMHLTENPH 180
AKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSLPADLTKMHLTENPH
Sbjct: 121 AKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSLPADLTKMHLTENPH 180
Query: 181 PQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDDEEEDEEI 240
PQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDDEEEDEEI
Sbjct: 181 PQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDDEEEDEEI 240
Query: 241 DRTDPLQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEV 300
DRTDPLQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEV
Sbjct: 241 DRTDPLQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEV 300
Query: 301 VEQAGAIILEDGQELDSWYVILNGTVEISHPDGKVENLFMGNSFGITPTLDKQYMHGIVR 360
VEQAGAIILEDGQELDSWYVILNGTVEISHPDGKVENLFMGNSFGITPTLDKQYMHGIVR
Sbjct: 301 VEQAGAIILEDGQELDSWYVILNGTVEISHPDGKVENLFMGNSFGITPTLDKQYMHGIVR 360
Query: 361 TKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKAT 420
TKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKAT
Sbjct: 361 TKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKAT 420
Query: 421 PERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDSLRDKVTRIVLL 480
PERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDSLRDKVTRIVLL
Sbjct: 421 PERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDSLRDKVTRIVLL 480
Query: 481 WVNNHFNDFEGDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRES 540
WVNNHFNDFEGDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRES
Sbjct: 481 WVNNHFNDFEGDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRES 540
Query: 541 PLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKAVEILRN 600
PLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKAVEILRN
Sbjct: 541 PLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKAVEILRN 600
Query: 601 NTHLALTVKTNIFVFKELLFRTEQEKSGVPHIPKIAEKKSNRHSIQHVPGDIEQTSQEKG 660
NTHLALTVKTNIFVFKELLFRTEQEKSGVPHIPKIAEKKSNRHSIQHVPGDIEQTSQEKG
Sbjct: 601 NTHLALTVKTNIFVFKELLFRTEQEKSGVPHIPKIAEKKSNRHSIQHVPGDIEQTSQEKG 660
Query: 661 SKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMP 720
SKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMP
Sbjct: 661 SKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMP 720
Query: 721 IPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKVDQQSCYIIISKDTTAKEVVFHA 780
IPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKVDQQSCYIIISKDTTAKEVVFHA
Sbjct: 721 IPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKVDQQSCYIIISKDTTAKEVVFHA 780
Query: 781 VHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLC 840
VHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLC
Sbjct: 781 VHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLC 840
Query: 841 SDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHL 900
SDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHL
Sbjct: 841 SDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHL 900
Query: 901 KRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLA 960
KRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLA
Sbjct: 901 KRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLA 960
Query: 961 SVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDM 1020
SVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDM
Sbjct: 961 SVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDM 1020
Query: 1021 TFLHEGNDSKVDGLVNFEKLRMISKEIRQVVRMTSANMDPAMMFRQRSLSQGSTNSNMLD 1080
TFLHEGNDSKVDGLVNFEKLRMISKEIRQVVRMTSANMDPAMMFRQRSLSQGSTNSNMLD
Sbjct: 1021 TFLHEGNDSKVDGLVNFEKLRMISKEIRQVVRMTSANMDPAMMFRQRSLSQGSTNSNMLD 1080
Query: 1081 VQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSLQWEPAYGT 1140
VQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSLQWEPAYGT
Sbjct: 1081 VQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSLQWEPAYGT 1140
Query: 1141 LTKNLSEKRSAKSSEMSPVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPIRKKGQTKD 1200
LTKNLSEKRSAKSSEMSPVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPIRKKGQTKD
Sbjct: 1141 LTKNLSEKRSAKSSEMSPVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPIRKKGQTKD 1200
Query: 1201 PALNTSLPQKVLGTTEEISGKKHTEDTISVASSLHSSPPASPQGSPHKGYTLIPSAKSDN 1260
PALNTSLPQKVLGTTEEISGKKHTEDTISVASSLHSSPPASPQGSPHKGYTLIPSAKSDN
Sbjct: 1201 PALNTSLPQKVLGTTEEISGKKHTEDTISVASSLHSSPPASPQGSPHKGYTLIPSAKSDN 1260
Query: 1261 LSDSSHSEISSRSSIVSNCSVDSMSAALQDERCSSQALAVPESTGALEKTEHASGIGDHS 1320
LSDSSHSEISSRSSIVSNCSVDSMSAALQDERCSSQALAVPESTGALEKTEHASGIGDHS
Sbjct: 1261 LSDSSHSEISSRSSIVSNCSVDSMSAALQDERCSSQALAVPESTGALEKTEHASGIGDHS 1320
Query: 1321 QHGPGWTLLKPSLIKCLAVSSSVSNEEISQEHIIIEAADSGRGSWTSCSSSSHDNFQSLP 1380
QHGPGWTLLKPSLIKCLAVSSSVSNEEISQEHIIIEAADSGRGSWTSCSSSSHDNFQSLP
Sbjct: 1321 QHGPGWTLLKPSLIKCLAVSSSVSNEEISQEHIIIEAADSGRGSWTSCSSSSHDNFQSLP 1380
Query: 1381 NPKSWDFLNSYRHTHLDDPIAEVEPTDSEPYSCSKSCSRTCGQCKGSLERKSWTSSSSLS 1440
NPKSWDFLNSYRHTHLDDPIAEVEPTDSEPYSCSKSCSRTCGQCKGSLERKSWTSSSSLS
Sbjct: 1381 NPKSWDFLNSYRHTHLDDPIAEVEPTDSEPYSCSKSCSRTCGQCKGSLERKSWTSSSSLS 1440
Query: 1441 DTYEPNYGTVKRRVLESTPAESSEGLDPKDATDPVYKTVTSSTEKGLIVYCVTSPKKDDR 1500
DTYEPNYGTVKRRVLESTPAESSEGLDPKDATDPVYKTVTSSTEKGLIVYCVTSPKKDDR
Sbjct: 1441 DTYEPNYGTVKRRVLESTPAESSEGLDPKDATDPVYKTVTSSTEKGLIVYCVTSPKKDDR 1500
Query: 1501 YREPPPTPPGYLGISLADLKEGPHTHLKPPDYSVAVQRSKMMHNSLSRLPPASLSSNLVA 1560
YREPPPTPPGYLGISLADLKEGPHTHLKPPDYSVAVQRSKMMHNSLSRLPPASLSSNLVA
Sbjct: 1501 YREPPPTPPGYLGISLADLKEGPHTHLKPPDYSVAVQRSKMMHNSLSRLPPASLSSNLVA 1560
Query: 1561 CVPSKIVTQPQRHNLQPFHPKLGDVTDADSEADENEQVSAV 1601
CVPSKIVTQPQRHNLQPFHPKLGDVTDADSEADENEQVSAV
Sbjct: 1561 CVPSKIVTQPQRHNLQPFHPKLGDVTDADSEADENEQVSAV 1601
>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
Length = 1499
Score = 1769 bits (4582), Expect = 0.0
Identities = 958/1494 (64%), Positives = 1120/1494 (74%), Gaps = 71/1494 (4%)
Query: 165 SLPADLTKMHLTENPHPQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLP 224
SLPAD TK+HLT++ HPQVTHVSSS SGCSI SDSGSSSLSDIYQATESE GD+DL+ LP
Sbjct: 20 SLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLP 79
Query: 225 EGPVDSEDDEEEDEEIDRTDPLQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANM 284
E VDSEDD++E++ +DPL RD+VR+CLEK+P D+TDDDIEQLLEFMHQLPAFANM
Sbjct: 80 ETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANM 139
Query: 285 TMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVEISHPDGKVENLFMGNSF 344
TMSVRRELC+VM+F VVE+AG I+L DG+ELDSW VILNG+VE+++PDGK E L MGNSF
Sbjct: 140 TMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSF 199
Query: 345 GITPTLDKQYMHGIVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRE 404
G++PT+DK+YM G++RTKVDDCQFVCIAQQDY RILN VEKN KVEEEGEIVMV EHRE
Sbjct: 200 GVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRE 259
Query: 405 LDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEW 464
LDR+GTRKGHIVIK T ERL MHL+EEHS+VDPT+IEDFLLTYRTFL SP++VG KLLEW
Sbjct: 260 LDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEW 319
Query: 465 FKIDSLRDKVTRIVLLWVNNHFNDFEGDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAA 524
F SLRDKVTR+VLLWVNNHFNDFEGDPAMTRFLEEFE NLE KM GHLRLLNIACAA
Sbjct: 320 FNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAA 379
Query: 525 KAKWRQVVLQKASRESPLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQ 584
KAK R + L K SRE+PL F L GGSEKGFGIFV+ V+ GSKA ++GLKRGDQI+EVNGQ
Sbjct: 380 KAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQ 439
Query: 585 NFENITFMKAVEILRNNTHLALTVKTNIFVFKELLFR-TEQEKSGVPHIPKIAE-KKSNR 642
NFENI KA+EILRNNTHL++TVKTN+FVFKELL R +E++++G PH+PKI + KK++R
Sbjct: 440 NFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEEKRNGAPHLPKIGDIKKASR 499
Query: 643 HSIQHVPGDIEQT-SQEKGSKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQS 701
+SI + D+EQ EK +KK KANTV GGRNK++KILDKTR SILP K ++D G+ QS
Sbjct: 500 YSIPDLAVDVEQVIGLEKVNKKSKANTV-GGRNKLKKILDKTRISILPQKPYNDIGIGQS 558
Query: 702 QDDSIVGTRHCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKVDQQ 761
QDDSIVG R +H +P+ GTLSSS+PDLLQ +LDFS D+PDQV+RVFK DQQ
Sbjct: 559 QDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFSATPDLPDQVLRVFKADQQ 618
Query: 762 SCYIIISKDTTAKEVVFHAVHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADR 821
S YI+ISKDTTAKEVV A+ EF +T D YSLCEVSVTPEGVIKQRRLPDQ SKLADR
Sbjct: 619 SRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADR 678
Query: 822 IQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEP 881
IQL+GRYYLKNNMETETLCSDEDAQEL++ESQ+S+LQLST+EVATQLSMR+F+LFRNIEP
Sbjct: 679 IQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEP 738
Query: 882 TEYIDDLFKLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHC 941
TEYIDDLFKL SKT +LKRFE+++NQETFWVASEIL E NQLKRMKIIKHFIKIALHC
Sbjct: 739 TEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHC 798
Query: 942 RECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILS 1001
RECKNFNSMFAIISGLNLA VARLR TWEKLP+KYEK QDLQD+FDPSRNMAKYRN+L+
Sbjct: 799 RECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLN 858
Query: 1002 SQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEKLRMISKEIRQVVRMTSANMDPA 1061
SQ++QPPIIPLFPV+KKD+TFLHEGNDSKVDGLVNFEKLRMI+KEIR V RM S NMDPA
Sbjct: 859 SQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPA 918
Query: 1062 MMFRQR--------SLSQGSTNSNMLDV-QGGAHKKRARRSSLLNAKKLYEDAQMARKVK 1112
+MFR R SLSQGSTN+ +LDV Q G HKKR RRSS LNAKKLYEDAQMARKVK
Sbjct: 919 LMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVK 978
Query: 1113 QYLSSLDVETDEEKFQMMSLQWEPAYGTLTKNLSEKRSAKSSEMSPVPMRSAGQTTKAHL 1172
QYLS+L++E DEE Q +SLQ EPA TL KN +K+ K SE SPV R+ Q L
Sbjct: 979 QYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVK-SETSPVAPRAGSQQKAQSL 1037
Query: 1173 HQP-------HRVSQVLQVPAVNLHPIRKKGQTKD-PALNTSLPQ---KVLGTTEEIS-- 1219
QP H+++Q LQVPAV+L+P RKK KD P + PQ K+L +EE S
Sbjct: 1038 PQPQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLE 1097
Query: 1220 -GKKHTEDTISVASSLHSSPPASPQGSPHKGYTLIPSAKSDNLSDSSHSEISSRSSIVSN 1278
KK EDTIS ASS SSPP SPQ SP KGYTL PS DN SDS HSEISSRSSIVSN
Sbjct: 1098 RHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDNFSDSGHSEISSRSSIVSN 1157
Query: 1279 CSVDSMSAALQDERCSSQALAVPESTGALEKTEHAS-------GIGDHSQHGPGWTLLKP 1331
S DS+ +L DER ++++ E+ + + E + +G ++ G
Sbjct: 1158 SSFDSVPVSLHDERRQRHSVSIVETNLGMGRMERRTMIEPDQYSLGSYAPMSEG-----R 1212
Query: 1332 SLIKCLAVSSSVSNEEISQ---EHIIIEAADSGRGSWTSCSSSSHDNFQSLPNPKSWDFL 1388
L V SS S EE+SQ + ++AADSGRGSWTSCSS SHDN Q++ + +SW+ L
Sbjct: 1213 GLYATATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWETL 1272
Query: 1389 NSYRHTHLD---DPI---AEVEPTDSEPYSCSKSCSRTCGQCKGSLE----RKSWTSSSS 1438
+ HTH D DP A D +S + Q + SLE R SW SS+
Sbjct: 1273 -PFGHTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTG 1331
Query: 1439 L-SDTYEPNYGTVKRR-------VLESTPAESSEGLDPKDATDPVYKTVTSSTEKGLIVY 1490
+ E + GT+KRR ES+ S + K P + V SST KGLI
Sbjct: 1332 YWGEDSEGDTGTIKRRGGKDVSIEAESSSLTSVTTEETKPVPMPAHIAVASSTTKGLIA- 1390
Query: 1491 CVTSPKKDDRYREPPPTPPGYLGISLADLKEG-PHTHLKPPDYSVAVQRSKMMHNSLSRL 1549
+K+ RYREPPPTPPGY+GI + D EG H KPPDY+VA+QRS+M+ S
Sbjct: 1391 -----RKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPDYNVALQRSRMVARSSDTA 1445
Query: 1550 PPASLSSNLVACVPSKIVTQPQRHNLQPFHPKLGDVTDA--DSEADENEQVSAV 1601
P+S+ S+ V +PQ H P+L +E DE+EQVSAV
Sbjct: 1446 GPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV 1499
Score = 32.0 bits (71), Expect = 4.9
Identities = 23/78 (29%), Positives = 39/78 (50%), Gaps = 5/78 (6%)
Query: 10 RQALRKKPPERTPEDLNTIYSYLHGMEILSNLR---EHQLRLMSARARYERYSGNQVLFC 66
R L K P +RT +D+ + ++H + +N+ +L + A ER +G VL
Sbjct: 108 RDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVER-AGTIVLND 166
Query: 67 SETIARCWYILLSGSVLV 84
E + W ++L+GSV V
Sbjct: 167 GEEL-DSWSVILNGSVEV 183
>gi|239752520 PREDICTED: similar to Rap guanine nucleotide exchange
factor 2, partial [Homo sapiens]
Length = 803
Score = 1181 bits (3056), Expect = 0.0
Identities = 591/785 (75%), Positives = 678/785 (86%), Gaps = 4/785 (0%)
Query: 165 SLPADLTKMHLTENPHPQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLP 224
SLPAD TK+HLT++ HPQVTHVSSS SGCSI SDSGSSSLSDIYQATESE GD+DL+ LP
Sbjct: 20 SLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLP 79
Query: 225 EGPVDSEDDEEEDEEIDRTDPLQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANM 284
E VDSEDD++E++ +DPL RD+VR+CLEK+P D+TDDDIEQLLEFMHQLPAFANM
Sbjct: 80 ETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANM 139
Query: 285 TMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVEISHPDGKVENLFMGNSF 344
TMSVRRELC+VM+F VVE+AG I+L DG+ELDSW VILNG+VE+++PDGK E L MGNSF
Sbjct: 140 TMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSF 199
Query: 345 GITPTLDKQYMHGIVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRE 404
G++PT+DK+YM G++RTKVDDCQFVCIAQQDY RILN VEKN KVEEEGEIVMV EHRE
Sbjct: 200 GVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRE 259
Query: 405 LDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEW 464
LDR+GTRKGHIVIK T ERL MHL+EEHS+VDPT+IEDFLLTYRTFL SP++VG KLLEW
Sbjct: 260 LDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEW 319
Query: 465 FKIDSLRDKVTRIVLLWVNNHFNDFEGDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAA 524
F SLRDKVTR+VLLWVNNHFNDFEGDPAMTRFLEEFE NLE KM GHLRLLNIACAA
Sbjct: 320 FNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAA 379
Query: 525 KAKWRQVVLQKASRESPLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQ 584
KAK R + L K SRE+PL F L GGSEKGFGIFV+ V+ GSKA ++GLKRGDQI+EVNGQ
Sbjct: 380 KAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQ 439
Query: 585 NFENITFMKAVEILRNNTHLALTVKTNIFVFKELLFR-TEQEKSGVPHIPKIAE-KKSNR 642
NFENI KA+EILRNNTHL++TVKTN+FVFKELL R +E++++G PH+PKI + KK++R
Sbjct: 440 NFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEEKRNGAPHLPKIGDIKKASR 499
Query: 643 HSIQHVPGDIEQT-SQEKGSKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQS 701
+SI + D+EQ EK +KK KANTV GGRNK++KILDKTR SILP K ++D G+ QS
Sbjct: 500 YSIPDLAVDVEQVIGLEKVNKKSKANTV-GGRNKLKKILDKTRISILPQKPYNDIGIGQS 558
Query: 702 QDDSIVGTRHCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKVDQQ 761
QDDSIVG R +H +P+ GTLSSS+PDLLQ +LDFS D+PDQV+RVFK DQQ
Sbjct: 559 QDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFSATPDLPDQVLRVFKADQQ 618
Query: 762 SCYIIISKDTTAKEVVFHAVHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADR 821
S YI+ISKDTTAKEVV A+ EF +T D YSLCEVSVTPEGVIKQRRLPDQ SKLADR
Sbjct: 619 SRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADR 678
Query: 822 IQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEP 881
IQL+GRYYLKNNMETETLCSDEDAQEL++ESQ+S+LQLST+EVATQLSMR+F+LFRNIEP
Sbjct: 679 IQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEP 738
Query: 882 TEYIDDLFKLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHC 941
TEYIDDLFKL SKT +LKRFE+++NQETFWVASEIL E NQLKRMKIIKHFIKIALHC
Sbjct: 739 TEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHC 798
Query: 942 RECKN 946
RECKN
Sbjct: 799 RECKN 803
Score = 32.0 bits (71), Expect = 4.9
Identities = 23/78 (29%), Positives = 39/78 (50%), Gaps = 5/78 (6%)
Query: 10 RQALRKKPPERTPEDLNTIYSYLHGMEILSNLR---EHQLRLMSARARYERYSGNQVLFC 66
R L K P +RT +D+ + ++H + +N+ +L + A ER +G VL
Sbjct: 108 RDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVER-AGTIVLND 166
Query: 67 SETIARCWYILLSGSVLV 84
E + W ++L+GSV V
Sbjct: 167 GEEL-DSWSVILNGSVEV 183
>gi|239753937 PREDICTED: similar to hCG2036828 [Homo sapiens]
Length = 275
Score = 172 bits (437), Expect = 2e-42
Identities = 88/138 (63%), Positives = 103/138 (74%), Gaps = 3/138 (2%)
Query: 24 DLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSVL 83
DL +YSYLHGME LSNLREHQLRLM RYER+ N+VL+ + I CWYILLSGSV
Sbjct: 116 DLEIVYSYLHGMEALSNLREHQLRLMCETVRYERHEANEVLYYPDDIGTCWYILLSGSVF 175
Query: 84 VKGSMVLPPCSFGKQFGG--KRGCDCLVLEPSEMIVVENAKDNEDSILQREIPARQSRRR 141
+K SM LP SFGK+ G +RGC+C+VLEPSEMIVV+ +NE+ QR+ RQSRRR
Sbjct: 176 IKESMFLPRSSFGKRSAGSFRRGCECIVLEPSEMIVVDYMDENEE-YFQRQASHRQSRRR 234
Query: 142 FRKINYKGERQTITDDVE 159
FRKIN KGERQTI D V+
Sbjct: 235 FRKINQKGERQTIIDTVD 252
Score = 31.2 bits (69), Expect = 8.4
Identities = 20/80 (25%), Positives = 41/80 (51%), Gaps = 8/80 (10%)
Query: 267 DIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTV 326
D+E + ++H + A +N+ R +C + +E +A ++ WY++L+G+V
Sbjct: 116 DLEIVYSYLHGMEALSNLREHQLRLMCETVRYE-RHEANEVLYYPDDIGTCWYILLSGSV 174
Query: 327 EISHPDGKVENLFM-GNSFG 345
I E++F+ +SFG
Sbjct: 175 FIK------ESMFLPRSSFG 188
>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform b
[Homo sapiens]
Length = 867
Score = 166 bits (421), Expect = 1e-40
Identities = 106/313 (33%), Positives = 172/313 (54%), Gaps = 11/313 (3%)
Query: 750 DQVI-RVFKVDQQSCYIIISKDTTAKEVVFHAVHEFGLTGASDTYSLCEVSVTPEGVIKQ 808
D+V+ +V+ +D I + T+ KEV+ + G + + + ++S E V+ +
Sbjct: 524 DEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLG---SGEGLIIVKMSSGGEKVVLK 580
Query: 809 RRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQL 868
F+ L +NGR + + ++L + + + + +S+ ++A Q+
Sbjct: 581 PNDVSVFTTLT----INGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQM 636
Query: 869 SMRDFDLFRNIEPTEYIDDLF-KLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKR 927
++ D++LF + E I F + N K +L F N+ FWV +EI + KR
Sbjct: 637 TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR 696
Query: 928 MKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIF 987
++++K FIKIA HC+E KN NS FAI+ GL+ +V+RL TWEKLPSK++K + + +
Sbjct: 697 VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM 756
Query: 988 DPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEKLRMISKEI 1047
DPSRN YR L+ ++PP+IP P++ KDMTF HEGN + +D LVNFEK+RMI+
Sbjct: 757 DPSRNHRAYR--LTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTA 814
Query: 1048 RQVVRMTSANMDP 1060
R V S +P
Sbjct: 815 RTVRYYRSQPFNP 827
Score = 113 bits (283), Expect = 1e-24
Identities = 88/316 (27%), Positives = 161/316 (50%), Gaps = 32/316 (10%)
Query: 225 EGPVDSEDDEEE-DEEIDRTDPL---QGRDL-VRECLEKEPADKTDDDIEQLLEFMHQLP 279
+ P+ +E++++E DEE+ T L G D +R L K P +T DD+E + E + +
Sbjct: 152 DAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIK 211
Query: 280 AFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVE-ISHPDGKVENL 338
A ++++ +V+REL V+IFE + G ++ G+E SWY+IL G+V + + G V L
Sbjct: 212 ALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTL 271
Query: 339 FMGNSFGITPTLDKQYMHGIVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVM 398
G+ FG ++ + + D+C F+ + ++D+ RIL VE NT +++E + V+
Sbjct: 272 HEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVL 331
Query: 399 VHEHRELDRSGTRKG-------HIVIKATPERLIMHLIE----EHSIVDPT--YIEDFLL 445
V E + +G + V+ TPE+++ H +E E ++ + T + DF++
Sbjct: 332 VLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIM 391
Query: 446 TYRTFLES----PLDVG------IKLLEWFKID---SLRDKVTRIVLLWVNNHFNDFEGD 492
+ F+ + P V + E K+D + + +V R+VL W + + + D
Sbjct: 392 MHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQED 451
Query: 493 PAMTRFLEEFEKNLED 508
FLEEF ++ D
Sbjct: 452 DVSMAFLEEFYVSVSD 467
Score = 47.0 bits (110), Expect = 1e-04
Identities = 34/98 (34%), Positives = 48/98 (48%), Gaps = 3/98 (3%)
Query: 6 DPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYS-GNQVL 64
D R LRK P +RT +DL IY L ++ LS+L R ++ +E ++ G VL
Sbjct: 181 DAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVL 240
Query: 65 FCSETIARCWYILLSGS--VLVKGSMVLPPCSFGKQFG 100
F WYI+L GS V++ G V+ G FG
Sbjct: 241 FNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFG 278
>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform a
[Homo sapiens]
Length = 1011
Score = 166 bits (421), Expect = 1e-40
Identities = 106/313 (33%), Positives = 172/313 (54%), Gaps = 11/313 (3%)
Query: 750 DQVI-RVFKVDQQSCYIIISKDTTAKEVVFHAVHEFGLTGASDTYSLCEVSVTPEGVIKQ 808
D+V+ +V+ +D I + T+ KEV+ + G + + + ++S E V+ +
Sbjct: 668 DEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLG---SGEGLIIVKMSSGGEKVVLK 724
Query: 809 RRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQL 868
F+ L +NGR + + ++L + + + + +S+ ++A Q+
Sbjct: 725 PNDVSVFTTLT----INGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQM 780
Query: 869 SMRDFDLFRNIEPTEYIDDLF-KLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKR 927
++ D++LF + E I F + N K +L F N+ FWV +EI + KR
Sbjct: 781 TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR 840
Query: 928 MKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIF 987
++++K FIKIA HC+E KN NS FAI+ GL+ +V+RL TWEKLPSK++K + + +
Sbjct: 841 VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM 900
Query: 988 DPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEKLRMISKEI 1047
DPSRN YR L+ ++PP+IP P++ KDMTF HEGN + +D LVNFEK+RMI+
Sbjct: 901 DPSRNHRAYR--LTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTA 958
Query: 1048 RQVVRMTSANMDP 1060
R V S +P
Sbjct: 959 RTVRYYRSQPFNP 971
Score = 113 bits (283), Expect = 1e-24
Identities = 88/316 (27%), Positives = 161/316 (50%), Gaps = 32/316 (10%)
Query: 225 EGPVDSEDDEEE-DEEIDRTDPL---QGRDL-VRECLEKEPADKTDDDIEQLLEFMHQLP 279
+ P+ +E++++E DEE+ T L G D +R L K P +T DD+E + E + +
Sbjct: 296 DAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIK 355
Query: 280 AFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVE-ISHPDGKVENL 338
A ++++ +V+REL V+IFE + G ++ G+E SWY+IL G+V + + G V L
Sbjct: 356 ALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTL 415
Query: 339 FMGNSFGITPTLDKQYMHGIVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVM 398
G+ FG ++ + + D+C F+ + ++D+ RIL VE NT +++E + V+
Sbjct: 416 HEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVL 475
Query: 399 VHEHRELDRSGTRKG-------HIVIKATPERLIMHLIE----EHSIVDPT--YIEDFLL 445
V E + +G + V+ TPE+++ H +E E ++ + T + DF++
Sbjct: 476 VLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIM 535
Query: 446 TYRTFLES----PLDVG------IKLLEWFKID---SLRDKVTRIVLLWVNNHFNDFEGD 492
+ F+ + P V + E K+D + + +V R+VL W + + + D
Sbjct: 536 MHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQED 595
Query: 493 PAMTRFLEEFEKNLED 508
FLEEF ++ D
Sbjct: 596 DVSMAFLEEFYVSVSD 611
Score = 47.8 bits (112), Expect = 9e-05
Identities = 30/129 (23%), Positives = 65/129 (50%), Gaps = 10/129 (7%)
Query: 255 CLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQE 314
CL+K P +++ +D++ + + ++ AF ++ ++C +E +E+ G + G
Sbjct: 18 CLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEK-GITLFRQGDI 76
Query: 315 LDSWYVILNGTVEI------SHPDG-KVENLFMGNSFGITPTLDKQYMHGIVRTKVDDCQ 367
+WY +L G++++ SH D + L +G +FG LD H + T+ + +
Sbjct: 77 GTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFG-ESILDNTPRHATIVTR-ESSE 134
Query: 368 FVCIAQQDY 376
+ I Q+D+
Sbjct: 135 LLRIEQKDF 143
Score = 47.0 bits (110), Expect = 1e-04
Identities = 34/98 (34%), Positives = 48/98 (48%), Gaps = 3/98 (3%)
Query: 6 DPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYS-GNQVL 64
D R LRK P +RT +DL IY L ++ LS+L R ++ +E ++ G VL
Sbjct: 325 DAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVL 384
Query: 65 FCSETIARCWYILLSGS--VLVKGSMVLPPCSFGKQFG 100
F WYI+L GS V++ G V+ G FG
Sbjct: 385 FNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFG 422
Score = 38.1 bits (87), Expect = 0.069
Identities = 23/75 (30%), Positives = 36/75 (48%)
Query: 13 LRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIAR 72
L K+P ER+ ED++ I++ L ++ + L + YE LF I
Sbjct: 19 LDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEKGITLFRQGDIGT 78
Query: 73 CWYILLSGSVLVKGS 87
WY +L+GS+ VK S
Sbjct: 79 NWYAVLAGSLDVKVS 93
>gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Homo
sapiens]
Length = 730
Score = 160 bits (404), Expect = 1e-38
Identities = 90/232 (38%), Positives = 140/232 (60%), Gaps = 4/232 (1%)
Query: 818 LADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFR 877
++ ++ +GR Y+ +TL + +E + S + +L ++T ++A +L D+ LF
Sbjct: 454 ISKSLEASGRIYVYRKDLADTLNPFAENEESQQRS-MRILGMNTWDLALELMNFDWSLFN 512
Query: 878 NIEPTEYIDDLFKLNSKTGNT-HLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIK 936
+I E I F +T +L N+ WVA+EIL + KR++++K FIK
Sbjct: 513 SIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIK 572
Query: 937 IALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKY 996
IA HC+ +N NS FAI+ GLN ASV+RL TWEK+P K++K +L+ + DPS N Y
Sbjct: 573 IAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAY 632
Query: 997 RNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEKLRMISKEIR 1048
R+ + + M+PP IP P++ KD+TF+HEGN + +D LVNFEKL MI+ +R
Sbjct: 633 RD--AFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVR 682
Score = 39.3 bits (90), Expect = 0.031
Identities = 54/262 (20%), Positives = 108/262 (41%), Gaps = 60/262 (22%)
Query: 284 MTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVEISHPDGKVENLFMGNS 343
+T +V+REL +V+ + + A +E +E + +V + T S PD +
Sbjct: 93 LTSAVQRELAAVIALKARKSA----IEQDEENNDKHVAV--TEAESVPDSQA-------- 138
Query: 344 FGITPTLDKQYMHGIVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHR 403
G+ L + R ++ + V ++ ++ L +K K E + + V + +
Sbjct: 139 -GVMCKLQE-------RDEIGRIELVQKLAKENYQFLQTDKKEQEKSEHQDDEVTTVQVK 190
Query: 404 ELDRS----------------GTRKGH---IVIKATPERLIMHLIEEHSIVD------PT 438
E D+S G+ + H +V+ TPE+++ HL+ + + + T
Sbjct: 191 EQDQSVLVLKKVQCCGPAPTAGSAESHWRYVVVSGTPEKILEHLLNDLHLEEVQDKETET 250
Query: 439 YIEDFLLTYRTFLESPLDVGIKLLEWFK------------IDSLRDKVTRIVLLWVNNHF 486
++DFLLTY F+ + D+ LL + + + KV +V W+ +
Sbjct: 251 LLDDFLLTYTVFMTTD-DLCQALLRHYSAKKYQGKEENSDVPRRKRKVLHLVSQWIALYK 309
Query: 487 NDFEGDPAMTRFLEEFEKNLED 508
+ D FL+ +N+ D
Sbjct: 310 DWLPEDEHSKMFLKTIYRNVLD 331
>gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b [Homo
sapiens]
Length = 881
Score = 146 bits (369), Expect = 1e-34
Identities = 89/253 (35%), Positives = 137/253 (54%), Gaps = 6/253 (2%)
Query: 818 LADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFR 877
+A + LN R ++ N E L D S + +S ++A QL+ D+ LF
Sbjct: 578 VATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFN 637
Query: 878 NIEPTEYIDDLF---KLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHF 934
+I E I + L T +L+RF N+ +WVA+E+ R ++++ F
Sbjct: 638 SIHQVELIHYVLGPQHLRDVT-TANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKF 696
Query: 935 IKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMA 994
IK+A H +E KN NS FA++ GL+ ++++RL TWE+LP K K L+ + DPS N
Sbjct: 697 IKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHR 756
Query: 995 KYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEKLRMISKEIRQVVRMT 1054
YR L+ + PP+IP P++ KDMTF+HEGN + V+ L+NFEK+RM+++ R +
Sbjct: 757 VYR--LALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCR 814
Query: 1055 SANMDPAMMFRQR 1067
S N P R R
Sbjct: 815 SHNPVPLSPLRSR 827
Score = 134 bits (337), Expect = 7e-31
Identities = 100/356 (28%), Positives = 174/356 (48%), Gaps = 35/356 (9%)
Query: 193 CSIASDSGSSSLSDIYQATESEVGDVDLTRLP---EGPVDSEDDEEEDEEIDRTDPLQGR 249
C + D G+ L + + D R P PV + + EEE E +G
Sbjct: 114 CQVLLDEGA--LCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGP 171
Query: 250 D-LVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAII 308
D L+ L K P +TD++++ + E + + A A+++ SV+REL +V++FE +AG ++
Sbjct: 172 DALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVL 231
Query: 309 LEDGQELDSWYVILNGTVE-ISHPDGKVENLFMGNSFGITPTLDKQYMHGIVRTKVDDCQ 367
G + SWY+I G+V ++H G V L G+ FG ++ + + D+C
Sbjct: 232 FSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCH 291
Query: 368 FVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGT------RKGHIVIKATP 421
F+ + +QD+ RI+ VE T ++EE G++V+V E + R + V+ TP
Sbjct: 292 FLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTP 351
Query: 422 ERLIMHLIE----EHSIVDP--TYIEDFLLTYRTFLESPLDVGIKLLEWFKID------- 468
E+++ L+E + S DP T++ DFLLT+R F+ S + LL F ++
Sbjct: 352 EKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPS-AQLCAALLHHFHVEPAGGSEQ 410
Query: 469 -------SLRDKVTRIVLLWVNNHFNDFEGDPAMTRFLEEFEKNL-EDTKMNGHLR 516
+ R ++ R+V WV + + DP T FL++ + DT+++ LR
Sbjct: 411 ERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLR 466
Score = 41.2 bits (95), Expect = 0.008
Identities = 29/92 (31%), Positives = 46/92 (50%), Gaps = 3/92 (3%)
Query: 12 ALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYS-GNQVLFCSETI 70
ALRK P +RT E+L+ I+ L ++ +++L R ++A +E +S VLF
Sbjct: 178 ALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDK 237
Query: 71 ARCWYILLSGS--VLVKGSMVLPPCSFGKQFG 100
WYI+ GS V+ G ++ G FG
Sbjct: 238 GTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFG 269
>gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [Homo
sapiens]
Length = 881
Score = 146 bits (369), Expect = 1e-34
Identities = 89/253 (35%), Positives = 137/253 (54%), Gaps = 6/253 (2%)
Query: 818 LADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFR 877
+A + LN R ++ N E L D S + +S ++A QL+ D+ LF
Sbjct: 578 VATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFN 637
Query: 878 NIEPTEYIDDLF---KLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHF 934
+I E I + L T +L+RF N+ +WVA+E+ R ++++ F
Sbjct: 638 SIHQVELIHYVLGPQHLRDVT-TANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKF 696
Query: 935 IKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMA 994
IK+A H +E KN NS FA++ GL+ ++++RL TWE+LP K K L+ + DPS N
Sbjct: 697 IKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHR 756
Query: 995 KYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEKLRMISKEIRQVVRMT 1054
YR L+ + PP+IP P++ KDMTF+HEGN + V+ L+NFEK+RM+++ R +
Sbjct: 757 VYR--LALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCR 814
Query: 1055 SANMDPAMMFRQR 1067
S N P R R
Sbjct: 815 SHNPVPLSPLRSR 827
Score = 134 bits (337), Expect = 7e-31
Identities = 100/356 (28%), Positives = 174/356 (48%), Gaps = 35/356 (9%)
Query: 193 CSIASDSGSSSLSDIYQATESEVGDVDLTRLP---EGPVDSEDDEEEDEEIDRTDPLQGR 249
C + D G+ L + + D R P PV + + EEE E +G
Sbjct: 114 CQVLLDEGA--LCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGP 171
Query: 250 D-LVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAII 308
D L+ L K P +TD++++ + E + + A A+++ SV+REL +V++FE +AG ++
Sbjct: 172 DALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVL 231
Query: 309 LEDGQELDSWYVILNGTVE-ISHPDGKVENLFMGNSFGITPTLDKQYMHGIVRTKVDDCQ 367
G + SWY+I G+V ++H G V L G+ FG ++ + + D+C
Sbjct: 232 FSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCH 291
Query: 368 FVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGT------RKGHIVIKATP 421
F+ + +QD+ RI+ VE T ++EE G++V+V E + R + V+ TP
Sbjct: 292 FLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTP 351
Query: 422 ERLIMHLIE----EHSIVDP--TYIEDFLLTYRTFLESPLDVGIKLLEWFKID------- 468
E+++ L+E + S DP T++ DFLLT+R F+ S + LL F ++
Sbjct: 352 EKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPS-AQLCAALLHHFHVEPAGGSEQ 410
Query: 469 -------SLRDKVTRIVLLWVNNHFNDFEGDPAMTRFLEEFEKNL-EDTKMNGHLR 516
+ R ++ R+V WV + + DP T FL++ + DT+++ LR
Sbjct: 411 ERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLR 466
Score = 41.2 bits (95), Expect = 0.008
Identities = 29/92 (31%), Positives = 46/92 (50%), Gaps = 3/92 (3%)
Query: 12 ALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYS-GNQVLFCSETI 70
ALRK P +RT E+L+ I+ L ++ +++L R ++A +E +S VLF
Sbjct: 178 ALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDK 237
Query: 71 ARCWYILLSGS--VLVKGSMVLPPCSFGKQFG 100
WYI+ GS V+ G ++ G FG
Sbjct: 238 GTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFG 269
>gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a [Homo
sapiens]
Length = 923
Score = 146 bits (369), Expect = 1e-34
Identities = 89/253 (35%), Positives = 137/253 (54%), Gaps = 6/253 (2%)
Query: 818 LADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFR 877
+A + LN R ++ N E L D S + +S ++A QL+ D+ LF
Sbjct: 620 VATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFN 679
Query: 878 NIEPTEYIDDLF---KLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHF 934
+I E I + L T +L+RF N+ +WVA+E+ R ++++ F
Sbjct: 680 SIHQVELIHYVLGPQHLRDVT-TANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKF 738
Query: 935 IKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMA 994
IK+A H +E KN NS FA++ GL+ ++++RL TWE+LP K K L+ + DPS N
Sbjct: 739 IKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHR 798
Query: 995 KYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEKLRMISKEIRQVVRMT 1054
YR L+ + PP+IP P++ KDMTF+HEGN + V+ L+NFEK+RM+++ R +
Sbjct: 799 VYR--LALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCR 856
Query: 1055 SANMDPAMMFRQR 1067
S N P R R
Sbjct: 857 SHNPVPLSPLRSR 869
Score = 134 bits (337), Expect = 7e-31
Identities = 100/356 (28%), Positives = 174/356 (48%), Gaps = 35/356 (9%)
Query: 193 CSIASDSGSSSLSDIYQATESEVGDVDLTRLP---EGPVDSEDDEEEDEEIDRTDPLQGR 249
C + D G+ L + + D R P PV + + EEE E +G
Sbjct: 156 CQVLLDEGA--LCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGP 213
Query: 250 D-LVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAII 308
D L+ L K P +TD++++ + E + + A A+++ SV+REL +V++FE +AG ++
Sbjct: 214 DALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVL 273
Query: 309 LEDGQELDSWYVILNGTVE-ISHPDGKVENLFMGNSFGITPTLDKQYMHGIVRTKVDDCQ 367
G + SWY+I G+V ++H G V L G+ FG ++ + + D+C
Sbjct: 274 FSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCH 333
Query: 368 FVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGT------RKGHIVIKATP 421
F+ + +QD+ RI+ VE T ++EE G++V+V E + R + V+ TP
Sbjct: 334 FLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTP 393
Query: 422 ERLIMHLIE----EHSIVDP--TYIEDFLLTYRTFLESPLDVGIKLLEWFKID------- 468
E+++ L+E + S DP T++ DFLLT+R F+ S + LL F ++
Sbjct: 394 EKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPS-AQLCAALLHHFHVEPAGGSEQ 452
Query: 469 -------SLRDKVTRIVLLWVNNHFNDFEGDPAMTRFLEEFEKNL-EDTKMNGHLR 516
+ R ++ R+V WV + + DP T FL++ + DT+++ LR
Sbjct: 453 ERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLR 508
Score = 41.2 bits (95), Expect = 0.008
Identities = 29/92 (31%), Positives = 46/92 (50%), Gaps = 3/92 (3%)
Query: 12 ALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYS-GNQVLFCSETI 70
ALRK P +RT E+L+ I+ L ++ +++L R ++A +E +S VLF
Sbjct: 220 ALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDK 279
Query: 71 ARCWYILLSGS--VLVKGSMVLPPCSFGKQFG 100
WYI+ GS V+ G ++ G FG
Sbjct: 280 GTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFG 311
>gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [Homo
sapiens]
Length = 456
Score = 145 bits (366), Expect = 3e-34
Identities = 90/272 (33%), Positives = 151/272 (55%), Gaps = 14/272 (5%)
Query: 788 GASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCS-DEDAQ 846
G D+ L VS + E V+ Q F+ L +N + E L E+ Q
Sbjct: 151 GREDSLILVAVSSSGEKVLLQPTEDCVFTALG----INSHLFACTRDSYEALVPLPEEIQ 206
Query: 847 ELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHLKRFEDI 906
V + ++ +VA L+ ++LFR + E++D +F + + G E +
Sbjct: 207 --VSPGDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVF--HGERGRRETANLELL 262
Query: 907 V---NQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVA 963
+ ++ T WVA+E+L KR +++K FIKIA C++ ++ S +A++ GL+ A+V+
Sbjct: 263 LQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVS 322
Query: 964 RLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFL 1023
RLR TWEKLP K++ + +++ DP RN YR ++S M+PP+IP P++ KD+TFL
Sbjct: 323 RLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVIS--KMKPPVIPFVPLILKDLTFL 380
Query: 1024 HEGNDSKVDGLVNFEKLRMISKEIRQVVRMTS 1055
HEG+ + VDGLVN EKL +++++R + + S
Sbjct: 381 HEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRS 412
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 99.0 bits (245), Expect = 3e-20
Identities = 62/177 (35%), Positives = 97/177 (54%), Gaps = 8/177 (4%)
Query: 863 EVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHLKRFEDIVNQETFWVASEILTEA 922
E+A QL++ D +LF IE E + + N + + +L +F + N ++WV S I+ +
Sbjct: 861 EIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEK-SPNLTQFTEHFNNMSYWVRSIIMLQE 919
Query: 923 NQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQD 982
R +++ FIKI H R+ NFNS AI+S L+ A + RL W+K S + L +
Sbjct: 920 KAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--WQKQTS---EGLAE 974
Query: 983 LQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEK 1039
+ D S + YR LS ++PP IP ++ +D+TF+H GN +DG VNF K
Sbjct: 975 YCTLIDSSSSFRAYRAALS--EVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSK 1029
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 99.0 bits (245), Expect = 3e-20
Identities = 62/177 (35%), Positives = 97/177 (54%), Gaps = 8/177 (4%)
Query: 863 EVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHLKRFEDIVNQETFWVASEILTEA 922
E+A QL++ D +LF IE E + + N + + +L +F + N ++WV S I+ +
Sbjct: 843 EIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEK-SPNLTQFTEHFNNMSYWVRSIIMLQE 901
Query: 923 NQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQD 982
R +++ FIKI H R+ NFNS AI+S L+ A + RL W+K S + L +
Sbjct: 902 KAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--WQKQTS---EGLAE 956
Query: 983 LQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEK 1039
+ D S + YR LS ++PP IP ++ +D+TF+H GN +DG VNF K
Sbjct: 957 YCTLIDSSSSFRAYRAALS--EVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSK 1011
>gi|40255197 RasGEF domain family, member 1C [Homo sapiens]
Length = 466
Score = 94.4 bits (233), Expect = 8e-19
Identities = 74/265 (27%), Positives = 127/265 (47%), Gaps = 37/265 (13%)
Query: 864 VATQLSMRDFDLFRNIEPTEYIDDLFK----------LNSKTGNTHLKRFEDIVNQETFW 913
+A QL+ + + R+I P E++ + KT N L+ + N+ +
Sbjct: 204 LAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSN--LEAYVKWFNRLCYL 261
Query: 914 VASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLP 973
VA+EI A + +R ++I+ FI +A C NFNS+ AIISG+N++ V+RL+ TW K+
Sbjct: 262 VATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVR 321
Query: 974 SKYEKHLQDLQDIFDPSRNMAKYRNIL---------SSQSMQPPIIPLFPVVKKDMTFLH 1024
+ L+ DP+ N YR L + S + +IP F ++ KD+ FL+
Sbjct: 322 T---AKFFILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYFLN 378
Query: 1025 EGNDSKV-DGLVNFEKLRMISKEIRQVVRMTSAN------------MDPAMMFRQRSLSQ 1071
EG +++ +G VNFEK ++K++ + + + A +F + L
Sbjct: 379 EGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDASITHYLYTAPIFSEDGLYL 438
Query: 1072 GSTNSNMLDVQGGAHKKRARRSSLL 1096
S S + Q + +A RSS+L
Sbjct: 439 ASYESESPENQTEKERWKALRSSIL 463
>gi|117168263 RasGEF domain family, member 1A [Homo sapiens]
Length = 481
Score = 93.6 bits (231), Expect = 1e-18
Identities = 63/207 (30%), Positives = 108/207 (52%), Gaps = 13/207 (6%)
Query: 858 QLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHLKRFEDIVNQETFWVASE 917
QL+ IE+ S+ DL + + + +D+ T L+ +++ N + VA+E
Sbjct: 221 QLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLVATE 280
Query: 918 ILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYE 977
+ + R ++++ FI +A C NFNSM AIISG+NL+ VARL+ TW K+ +
Sbjct: 281 VCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKT--- 337
Query: 978 KHLQDLQDIFDPSRNMAKYRNIL---------SSQSMQPPIIPLFPVVKKDMTFLHEGND 1028
L+ DPS N YR L ++ S + +IP+F + KD+ FLH+ +
Sbjct: 338 AKFDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHT 397
Query: 1029 SKV-DGLVNFEKLRMISKEIRQVVRMT 1054
+ + +G +NF+K IS++I + + T
Sbjct: 398 NHLPNGHINFKKFWEISRQIHEFMTWT 424
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 92.0 bits (227), Expect = 4e-18
Identities = 60/205 (29%), Positives = 104/205 (50%), Gaps = 6/205 (2%)
Query: 859 LSTIEVATQLSMRDFDLFRNIEPTEYIDD-LFKLNSKTGNTHLKRFEDIVNQETFWVASE 917
LS +E+A Q+++ D +FR+I E++ KL+ ++ + N + VAS+
Sbjct: 1001 LSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQ 1060
Query: 918 ILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYE 977
I+ A+ R I+ ++ +A CR N+N + I S LN +++ RL+ TW K+ + +
Sbjct: 1061 IMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTK 1120
Query: 978 KHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDS-KVDGLVN 1036
+ LQ R L ++ PP +P + D+ F+ EG + +GLVN
Sbjct: 1121 ALMDKLQKTVSSEGRFKNLRETL--KNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVN 1178
Query: 1037 FEKLRMISKEIRQV--VRMTSANMD 1059
F K+RMIS IR++ + TS +D
Sbjct: 1179 FSKMRMISHIIREIRQFQQTSYRID 1203
>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
Length = 473
Score = 91.3 bits (225), Expect = 7e-18
Identities = 60/206 (29%), Positives = 108/206 (52%), Gaps = 23/206 (11%)
Query: 864 VATQLSMRDFDLFRNIEPTEYI----------DDLFKLNSKTGNTHLKRFEDIVNQETFW 913
+A QL+ + + I P E++ +D + + +L+ + + N+ ++
Sbjct: 209 LAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYL 268
Query: 914 VASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLP 973
VA+EI + R ++I++FI +A C NFNS+ AIISG+N++ V+RL+ TW K+
Sbjct: 269 VATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVK 328
Query: 974 SKYEKHLQDLQDIFDPSRNMAKYRNIL---------SSQSMQPPIIPLFPVVKKDMTFLH 1024
+ L+ DPS N YR L + S + +IP F ++ KD+ FL+
Sbjct: 329 T---AKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLN 385
Query: 1025 EGNDSKV-DGLVNFEKLRMISKEIRQ 1049
EG +++ +G VNFEK ++K++ +
Sbjct: 386 EGCANRLPNGHVNFEKFWELAKQVSE 411
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 88.6 bits (218), Expect = 4e-17
Identities = 59/197 (29%), Positives = 98/197 (49%), Gaps = 12/197 (6%)
Query: 860 STIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHL-----KRFEDIVNQETFWV 914
S +E+A QL++ D +F+ I E+ + K T K F DI N +
Sbjct: 1022 SALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNL----I 1077
Query: 915 ASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPS 974
ASEI+ + R+ I+ ++ +A CR N+N++ I S +N +++ RL+ TW K+
Sbjct: 1078 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 1137
Query: 975 KYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKV-DG 1033
+ + + LQ + R L ++ PP +P + D+ F+ EG + DG
Sbjct: 1138 QTKALIDKLQKLVSSEGRFKNLREAL--KNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDG 1195
Query: 1034 LVNFEKLRMISKEIRQV 1050
LVNF K+RMIS IR++
Sbjct: 1196 LVNFSKMRMISHIIREI 1212
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 88.6 bits (218), Expect = 4e-17
Identities = 59/197 (29%), Positives = 98/197 (49%), Gaps = 12/197 (6%)
Query: 860 STIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHL-----KRFEDIVNQETFWV 914
S +E+A QL++ D +F+ I E+ + K T K F DI N +
Sbjct: 1038 SALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNL----I 1093
Query: 915 ASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPS 974
ASEI+ + R+ I+ ++ +A CR N+N++ I S +N +++ RL+ TW K+
Sbjct: 1094 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 1153
Query: 975 KYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKV-DG 1033
+ + + LQ + R L ++ PP +P + D+ F+ EG + DG
Sbjct: 1154 QTKALIDKLQKLVSSEGRFKNLREAL--KNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDG 1211
Query: 1034 LVNFEKLRMISKEIRQV 1050
LVNF K+RMIS IR++
Sbjct: 1212 LVNFSKMRMISHIIREI 1228
>gi|24797101 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 2 [Homo sapiens]
Length = 489
Score = 88.6 bits (218), Expect = 4e-17
Identities = 59/197 (29%), Positives = 98/197 (49%), Gaps = 12/197 (6%)
Query: 860 STIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHL-----KRFEDIVNQETFWV 914
S +E+A QL++ D +F+ I E+ + K T K F DI N +
Sbjct: 254 SALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNL----I 309
Query: 915 ASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPS 974
ASEI+ + R+ I+ ++ +A CR N+N++ I S +N +++ RL+ TW K+
Sbjct: 310 ASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSK 369
Query: 975 KYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKV-DG 1033
+ + + LQ + R L ++ PP +P + D+ F+ EG + DG
Sbjct: 370 QTKALIDKLQKLVSSEGRFKNLREAL--KNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDG 427
Query: 1034 LVNFEKLRMISKEIRQV 1050
LVNF K+RMIS IR++
Sbjct: 428 LVNFSKMRMISHIIREI 444
>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
Length = 1333
Score = 85.1 bits (209), Expect = 5e-16
Identities = 57/203 (28%), Positives = 106/203 (52%), Gaps = 14/203 (6%)
Query: 856 MLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTH--LKRFEDIVNQETFW 913
+L L IE+A QL++ + DL+R ++P+E + ++ K N+ LK N T W
Sbjct: 776 LLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNL-TLW 834
Query: 914 VASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLP 973
I+ N +R+ ++ I+I +E NFN + ++S +N + V RL T+E++P
Sbjct: 835 FEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIP 894
Query: 974 SKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKV-- 1031
S+ +K L++ ++ + + KY + +S+ PP +P F + ++ EGN +
Sbjct: 895 SRQKKILEEAHELSED--HYKKY--LAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKR 950
Query: 1032 --DGLVNFEKLRMISK---EIRQ 1049
L+NF K R +++ EI+Q
Sbjct: 951 HGKELINFSKRRKVAEITGEIQQ 973
Score = 41.2 bits (95), Expect = 0.008
Identities = 29/123 (23%), Positives = 47/123 (38%), Gaps = 31/123 (25%)
Query: 411 RKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFL------------------- 451
+ G +IKA ++ + H DP ++ FL TYR+F
Sbjct: 595 KAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPE 654
Query: 452 ------------ESPLDVGIKLLEWFKIDSLRDKVTRIVLLWVNNHFNDFEGDPAMTRFL 499
+ PL +K I ++ +V + WV +HF DFE D + + +
Sbjct: 655 PTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRM 714
Query: 500 EEF 502
EEF
Sbjct: 715 EEF 717
>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
Length = 1332
Score = 80.5 bits (197), Expect = 1e-14
Identities = 57/203 (28%), Positives = 102/203 (50%), Gaps = 14/203 (6%)
Query: 856 MLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTH--LKRFEDIVNQETFW 913
++ L IE+A QL++ + DL+R ++P+E + ++ K N+ LK N T W
Sbjct: 774 LMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNL-TLW 832
Query: 914 VASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLP 973
I+ N +R+ ++ I+I ++ NFN + I+S +N SV RL T+E L
Sbjct: 833 FEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQ 892
Query: 974 SKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGND----S 1029
+ K L + ++ + KY ++ +S+ PP +P F + ++ EGN+
Sbjct: 893 ERKRKILDEAVEL--SQDHFKKY--LVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKK 948
Query: 1030 KVDGLVNFEKLRMISK---EIRQ 1049
K L+NF K R +++ EI+Q
Sbjct: 949 KGKDLINFSKRRKVAEITGEIQQ 971
Score = 41.2 bits (95), Expect = 0.008
Identities = 38/155 (24%), Positives = 58/155 (37%), Gaps = 39/155 (25%)
Query: 390 VEEEGEIVMVHEHRELDRSGTR--KGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTY 447
V ++ E +V E RSG KG V+K ERL H+ DP ++ FL TY
Sbjct: 576 VVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLI-ERLTYHMY-----ADPNFVRTFLTTY 629
Query: 448 RTFL-------------------------------ESPLDVGIKLLEWFKIDSLRDKVTR 476
R+F E P+ +K + ++ ++
Sbjct: 630 RSFCKPQELLSLLIERFEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILN 689
Query: 477 IVLLWVNNHFNDFEGDPAMTRFLEEFEKNLEDTKM 511
+ WV +HF DFE D + LE F ++ M
Sbjct: 690 VFRHWVEHHFYDFERDLELLERLESFISSVRGKAM 724
>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
sapiens]
Length = 583
Score = 78.6 bits (192), Expect = 5e-14
Identities = 51/194 (26%), Positives = 92/194 (47%), Gaps = 2/194 (1%)
Query: 856 MLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNT-HLKRFEDIVNQETFWV 914
+L+++ E A Q+++ D +F+ I+P E + K + + F N +FWV
Sbjct: 45 VLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWV 104
Query: 915 ASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPS 974
EIL R +++ H+IK A E N +++ A++SGL A + RL TW L
Sbjct: 105 VREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSR 164
Query: 975 KYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGL 1034
K + + L+ + N + R+ +SS M P IP + D+T++ S L
Sbjct: 165 KDKTTFEKLEYVMSKEDNYKRLRDYISSLKM-TPCIPYLGIYLSDLTYIDSAYPSTGSIL 223
Query: 1035 VNFEKLRMISKEIR 1048
N ++ +++ +R
Sbjct: 224 ENEQRSNLMNNILR 237
>gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo
sapiens]
Length = 907
Score = 78.2 bits (191), Expect = 6e-14
Identities = 37/68 (54%), Positives = 52/68 (76%)
Query: 542 LQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKAVEILRNN 601
L ++ GG+E G GI++ GV+PGS+A SGLK GDQI+EVNG++F NI +AV +L+++
Sbjct: 290 LGLTIRGGAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKSS 349
Query: 602 THLALTVK 609
HL LTVK
Sbjct: 350 RHLILTVK 357
Score = 74.7 bits (182), Expect = 7e-13
Identities = 52/165 (31%), Positives = 84/165 (50%), Gaps = 15/165 (9%)
Query: 523 AAKAKWRQVVLQKASRESPLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVN 582
A + R V L++A L FS+ GGSE G GI+V VEPGS A GL+ GDQI+ VN
Sbjct: 133 AGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVN 192
Query: 583 GQNFENITFMKAVEILRNNTHLALT-----------VKTNIFVFKELLFRTEQEKSGV-- 629
++ +T +AV+ L+ + L L+ V +I+ + + R+ SG+
Sbjct: 193 DKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSGLPQ 252
Query: 630 PHIPKIAEKKSNRHSIQHV--PGDIEQTSQEKGSKKVKANTVSGG 672
PH + +++ +R S H+ GD ++ + G + T+ GG
Sbjct: 253 PHGGALRQQEGDRRSTLHLLQGGDEKKVNLVLGDGRSLGLTIRGG 297
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapiens]
Length = 762
Score = 76.6 bits (187), Expect = 2e-13
Identities = 65/240 (27%), Positives = 117/240 (48%), Gaps = 13/240 (5%)
Query: 817 KLADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSML--QLSTIEVATQLSMRDFD 874
+L D Q+N R + + T+ + S+ K+ ++S+L L E++ L+ +F
Sbjct: 167 RLIDTTQINARDWSRKL--TQRIKSNTS-----KKRKVSLLFDHLEPEELSEHLTYLEFK 219
Query: 875 LFRNIEPTEYIDDLFKLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHF 934
FR I ++Y + L K T ++R + N + WV +L+ R ++ F
Sbjct: 220 SFRRISFSDYQNYLVNSCVKENPT-MERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKF 278
Query: 935 IKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMA 994
I++A + +NFN++ A+I GL +S++RL+ T +P + K L ++ ++ SRN
Sbjct: 279 IQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYD 338
Query: 995 KYRNILSSQSMQPPIIPLFPVVKKDMTFLHEG-NDSKVDGLVNFEKLRMISKEIRQVVRM 1053
YR + IP+ V KD+ L+E D DG VN KL + I ++V++
Sbjct: 339 NYRRAYGECTDFK--IPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQL 396
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapiens]
Length = 797
Score = 76.6 bits (187), Expect = 2e-13
Identities = 65/240 (27%), Positives = 117/240 (48%), Gaps = 13/240 (5%)
Query: 817 KLADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSML--QLSTIEVATQLSMRDFD 874
+L D Q+N R + + T+ + S+ K+ ++S+L L E++ L+ +F
Sbjct: 167 RLIDTTQINARDWSRKL--TQRIKSNTS-----KKRKVSLLFDHLEPEELSEHLTYLEFK 219
Query: 875 LFRNIEPTEYIDDLFKLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHF 934
FR I ++Y + L K T ++R + N + WV +L+ R ++ F
Sbjct: 220 SFRRISFSDYQNYLVNSCVKENPT-MERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKF 278
Query: 935 IKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMA 994
I++A + +NFN++ A+I GL +S++RL+ T +P + K L ++ ++ SRN
Sbjct: 279 IQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYD 338
Query: 995 KYRNILSSQSMQPPIIPLFPVVKKDMTFLHEG-NDSKVDGLVNFEKLRMISKEIRQVVRM 1053
YR + IP+ V KD+ L+E D DG VN KL + I ++V++
Sbjct: 339 NYRRAYGECTDFK--IPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQL 396
>gi|93102367 ral guanine nucleotide dissociation stimulator-like 1
[Homo sapiens]
Length = 803
Score = 75.9 bits (185), Expect = 3e-13
Identities = 84/319 (26%), Positives = 126/319 (39%), Gaps = 54/319 (16%)
Query: 832 NNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKL 891
N + S E+ +EL S VA QL+ D LF+ + P + ++
Sbjct: 239 NGLPNTISFSLEEEEELEGGESAEFTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSR 298
Query: 892 NSKTGNTHL----KRFEDIVNQETFWVASEIL--TEANQLKRMKIIKHFIKIALHCRECK 945
K N HL + N T V S IL E +R KII+ +I IA CR K
Sbjct: 299 RDKKENKHLAPTIRATISQFNTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLK 358
Query: 946 NFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRN------------M 993
NF+S+ AI+S L S+ RL+ TW +P ++L DIF N
Sbjct: 359 NFSSLRAIVSALQSNSIYRLKKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGT 418
Query: 994 AKYRNILSS-----------------QSMQPPIIPLFPVVKKDMTFLHEGNDSKVDG-LV 1035
+K+ N+ SS + +P D+T L ++G L+
Sbjct: 419 SKFANLDSSVKENQKRTQRRLQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLI 478
Query: 1036 NFEKLRMISKEIRQVVRMTSA----NMDPAMMF-----RQRSLSQGSTNSNMLDVQGGA- 1085
NFEK R + I Q+ + SA M P F RQ+ L++ + + +++ A
Sbjct: 479 NFEKRRREFEVIAQIKLLQSACNSYCMTPDQKFIQWFQRQQLLTEEESYALSCEIEAAAD 538
Query: 1086 --------HKKRARRSSLL 1096
K +R SLL
Sbjct: 539 ASTTSPKPRKSMVKRLSLL 557
>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
sapiens]
Length = 557
Score = 75.1 bits (183), Expect = 5e-13
Identities = 50/194 (25%), Positives = 90/194 (46%), Gaps = 2/194 (1%)
Query: 856 MLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNT-HLKRFEDIVNQETFWV 914
+L+++ E A+Q+++ D +F+ I+P E + K ++ F NQ +FWV
Sbjct: 46 VLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWV 105
Query: 915 ASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPS 974
EILT R +I+ HF+KIA E N +S+ +++S L A + RL TW L
Sbjct: 106 VREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNR 165
Query: 975 KYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGL 1034
K + + L + N + R + S M P IP + D+ ++ + +
Sbjct: 166 KDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPS-IPYLGIYLLDLIYIDSAYPASGSIM 224
Query: 1035 VNFEKLRMISKEIR 1048
N ++ ++ +R
Sbjct: 225 ENEQRSNQMNNILR 238
>gi|24307909 ral guanine nucleotide dissociation stimulator isoform 1
[Homo sapiens]
Length = 914
Score = 74.7 bits (182), Expect = 7e-13
Identities = 61/243 (25%), Positives = 103/243 (42%), Gaps = 33/243 (13%)
Query: 845 AQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHLK--- 901
A+ + E + +L VA Q ++ D +LF+ + P + ++ K G HL
Sbjct: 371 AENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTI 430
Query: 902 -----RFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISG 956
+F + N T+A R ++++H+I++A CR KNF+S++AI+S
Sbjct: 431 RATVTQFNSVANCVITTCLGNRSTKAPD--RARVVEHWIEVARECRILKNFSSLYAILSA 488
Query: 957 LNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNIL--------SSQSMQPP 1008
L S+ RL+ TWE + + Q L +IF N + R +L ++ M P
Sbjct: 489 LQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPK 548
Query: 1009 --------------IIPLFPVVKKDMTFLHEGNDSKVDG-LVNFEKLRMISKEIRQVVRM 1053
+P D+ L + G L+NFEK R + I Q+ +
Sbjct: 549 RAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLL 608
Query: 1054 TSA 1056
SA
Sbjct: 609 QSA 611
>gi|108796058 ral guanine nucleotide dissociation stimulator isoform 2
[Homo sapiens]
Length = 859
Score = 74.7 bits (182), Expect = 7e-13
Identities = 61/243 (25%), Positives = 103/243 (42%), Gaps = 33/243 (13%)
Query: 845 AQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHLK--- 901
A+ + E + +L VA Q ++ D +LF+ + P + ++ K G HL
Sbjct: 316 AENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTI 375
Query: 902 -----RFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISG 956
+F + N T+A R ++++H+I++A CR KNF+S++AI+S
Sbjct: 376 RATVTQFNSVANCVITTCLGNRSTKAPD--RARVVEHWIEVARECRILKNFSSLYAILSA 433
Query: 957 LNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNIL--------SSQSMQPP 1008
L S+ RL+ TWE + + Q L +IF N + R +L ++ M P
Sbjct: 434 LQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPK 493
Query: 1009 --------------IIPLFPVVKKDMTFLHEGNDSKVDG-LVNFEKLRMISKEIRQVVRM 1053
+P D+ L + G L+NFEK R + I Q+ +
Sbjct: 494 RAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLL 553
Query: 1054 TSA 1056
SA
Sbjct: 554 QSA 556
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,037,025
Number of Sequences: 37866
Number of extensions: 2953176
Number of successful extensions: 11285
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 155
Number of HSP's successfully gapped in prelim test: 154
Number of HSP's that attempted gapping in prelim test: 10406
Number of HSP's gapped (non-prelim): 907
length of query: 1601
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1485
effective length of database: 13,855,062
effective search space: 20574767070
effective search space used: 20574767070
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.