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Search of human proteins with 5453862
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
(647 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 1306 0.0
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 1253 0.0
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 1253 0.0
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 1253 0.0
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 744 0.0
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 744 0.0
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens] 736 0.0
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens] 736 0.0
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens] 736 0.0
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens] 736 0.0
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 688 0.0
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 688 0.0
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 688 0.0
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens] 237 2e-62
gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens] 237 2e-62
gi|4826894 phosphodiesterase 1C [Homo sapiens] 234 1e-61
gi|4505677 phosphodiesterase 1B [Homo sapiens] 231 1e-60
gi|9506959 phosphodiesterase 7B [Homo sapiens] 216 7e-56
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens] 214 2e-55
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens] 214 2e-55
gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens] 211 2e-54
gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens] 211 2e-54
gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens] 211 2e-54
gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens] 211 2e-54
gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens] 211 2e-54
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens] 209 5e-54
gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens] 194 2e-49
gi|40254434 phosphodiesterase 3B [Homo sapiens] 178 2e-44
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 177 4e-44
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 177 4e-44
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 1306 bits (3381), Expect = 0.0
Identities = 647/647 (100%), Positives = 647/647 (100%)
Query: 1 MPLVDFFCETCSKPWLVGWWDQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVE 60
MPLVDFFCETCSKPWLVGWWDQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVE
Sbjct: 1 MPLVDFFCETCSKPWLVGWWDQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVE 60
Query: 61 IPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKT 120
IPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKT
Sbjct: 61 IPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKT 120
Query: 121 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 180
DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM
Sbjct: 121 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 180
Query: 181 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 240
LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG
Sbjct: 181 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 240
Query: 241 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVID 300
VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVID
Sbjct: 241 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVID 300
Query: 301 MVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPL 360
MVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPL
Sbjct: 301 MVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPL 360
Query: 361 ELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 420
ELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD
Sbjct: 361 ELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 420
Query: 421 LVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE 480
LVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE
Sbjct: 421 LVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE 480
Query: 481 EISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYL 540
EISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYL
Sbjct: 481 EISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYL 540
Query: 541 TQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGL 600
TQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGL
Sbjct: 541 TQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGL 600
Query: 601 PSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT 647
PSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
Sbjct: 601 PSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT 647
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 1253 bits (3242), Expect = 0.0
Identities = 625/626 (99%), Positives = 626/626 (100%)
Query: 22 QFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQ 81
+FKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQ
Sbjct: 200 KFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQ 259
Query: 82 PPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIF 141
PPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIF
Sbjct: 260 PPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIF 319
Query: 142 CVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAAD 201
CVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAAD
Sbjct: 320 CVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAAD 379
Query: 202 VLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDES 261
VLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDES
Sbjct: 380 VLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDES 439
Query: 262 VLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 321
VLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV
Sbjct: 440 VLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 499
Query: 322 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 381
ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE
Sbjct: 500 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 559
Query: 382 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYY 441
RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYY
Sbjct: 560 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYY 619
Query: 442 SAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLS 501
SAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLS
Sbjct: 620 SAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLS 679
Query: 502 GVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSRE 561
GVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSRE
Sbjct: 680 GVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSRE 739
Query: 562 EFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACS 621
EFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACS
Sbjct: 740 EFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACS 799
Query: 622 ACAGTFGEDTSALPAPGGGGSGGDPT 647
ACAGTFGEDTSALPAPGGGGSGGDPT
Sbjct: 800 ACAGTFGEDTSALPAPGGGGSGGDPT 825
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 1253 bits (3242), Expect = 0.0
Identities = 625/626 (99%), Positives = 626/626 (100%)
Query: 22 QFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQ 81
+FKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQ
Sbjct: 235 KFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQ 294
Query: 82 PPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIF 141
PPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIF
Sbjct: 295 PPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIF 354
Query: 142 CVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAAD 201
CVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAAD
Sbjct: 355 CVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAAD 414
Query: 202 VLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDES 261
VLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDES
Sbjct: 415 VLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDES 474
Query: 262 VLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 321
VLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV
Sbjct: 475 VLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 534
Query: 322 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 381
ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE
Sbjct: 535 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 594
Query: 382 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYY 441
RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYY
Sbjct: 595 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYY 654
Query: 442 SAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLS 501
SAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLS
Sbjct: 655 SAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLS 714
Query: 502 GVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSRE 561
GVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSRE
Sbjct: 715 GVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSRE 774
Query: 562 EFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACS 621
EFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACS
Sbjct: 775 EFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACS 834
Query: 622 ACAGTFGEDTSALPAPGGGGSGGDPT 647
ACAGTFGEDTSALPAPGGGGSGGDPT
Sbjct: 835 ACAGTFGEDTSALPAPGGGGSGGDPT 860
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 1253 bits (3242), Expect = 0.0
Identities = 625/626 (99%), Positives = 626/626 (100%)
Query: 22 QFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQ 81
+FKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQ
Sbjct: 261 KFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQ 320
Query: 82 PPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIF 141
PPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIF
Sbjct: 321 PPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIF 380
Query: 142 CVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAAD 201
CVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAAD
Sbjct: 381 CVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAAD 440
Query: 202 VLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDES 261
VLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDES
Sbjct: 441 VLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDES 500
Query: 262 VLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 321
VLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV
Sbjct: 501 VLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 560
Query: 322 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 381
ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE
Sbjct: 561 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 620
Query: 382 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYY 441
RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYY
Sbjct: 621 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYY 680
Query: 442 SAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLS 501
SAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLS
Sbjct: 681 SAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLS 740
Query: 502 GVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSRE 561
GVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSRE
Sbjct: 741 GVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSRE 800
Query: 562 EFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACS 621
EFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACS
Sbjct: 801 EFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACS 860
Query: 622 ACAGTFGEDTSALPAPGGGGSGGDPT 647
ACAGTFGEDTSALPAPGGGGSGGDPT
Sbjct: 861 ACAGTFGEDTSALPAPGGGGSGGDPT 886
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 744 bits (1921), Expect = 0.0
Identities = 375/507 (73%), Positives = 432/507 (85%), Gaps = 26/507 (5%)
Query: 21 DQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPS 80
++FKRMLNRELTHLSEMSRSGNQVSE+IS TFLDKQ+EVEIPSPT KE+EK++
Sbjct: 306 NKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKK------- 358
Query: 81 QPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNI 140
+PMSQI+G+KKLMHS+SL NS+IPRFGVKT+QE++LA+ELE++NKWGL++
Sbjct: 359 ----------RPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHV 408
Query: 141 FCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAA 200
F +++ +G R LT IM+ IFQERDLLK F+IPVDT++TY++TLEDHYHADVAYHN++HAA
Sbjct: 409 FRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAA 468
Query: 201 DVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 260
DV+QSTHVLL+TPAL+AVFTDLEILAA+FA+AIHDVDHPGVSNQFLINTNSELALMYND
Sbjct: 469 DVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDS 528
Query: 261 SVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTM 320
SVLENHHLAVGFKLLQE+NCDIFQNL+K+QRQSLRKMVID+VLATDMSKHM LLADLKTM
Sbjct: 529 SVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTM 588
Query: 321 VETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDR 380
VETKKVTSSGVLLLDNYSDRIQVL+NMVHCADLSNPTKPL+LYRQWTDRIM EFF+QGDR
Sbjct: 589 VETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDR 648
Query: 381 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWY 440
ERERGMEISPMCDKH ASVEKSQVGFIDYIVHPLWETWADLVHPDAQ+ILDTLEDNR+WY
Sbjct: 649 ERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWY 708
Query: 441 YSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEE---EEISMAQI----PCTAQE 493
S I QSPSP P++ G +KFQFELTLEE+ E E+ S +Q+ C+ +
Sbjct: 709 QSTIPQSPSPAPDDPEE--GRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSK 766
Query: 494 ALTAQGLSGVEEALDATIAWEASPAQE 520
L Q E LD + EA +E
Sbjct: 767 TLCTQDSESTEIPLDEQVEEEAVGEEE 793
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 744 bits (1921), Expect = 0.0
Identities = 375/507 (73%), Positives = 432/507 (85%), Gaps = 26/507 (5%)
Query: 21 DQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPS 80
++FKRMLNRELTHLSEMSRSGNQVSE+IS TFLDKQ+EVEIPSPT KE+EK++
Sbjct: 170 NKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKK------- 222
Query: 81 QPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNI 140
+PMSQI+G+KKLMHS+SL NS+IPRFGVKT+QE++LA+ELE++NKWGL++
Sbjct: 223 ----------RPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHV 272
Query: 141 FCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAA 200
F +++ +G R LT IM+ IFQERDLLK F+IPVDT++TY++TLEDHYHADVAYHN++HAA
Sbjct: 273 FRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAA 332
Query: 201 DVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 260
DV+QSTHVLL+TPAL+AVFTDLEILAA+FA+AIHDVDHPGVSNQFLINTNSELALMYND
Sbjct: 333 DVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDS 392
Query: 261 SVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTM 320
SVLENHHLAVGFKLLQE+NCDIFQNL+K+QRQSLRKMVID+VLATDMSKHM LLADLKTM
Sbjct: 393 SVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTM 452
Query: 321 VETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDR 380
VETKKVTSSGVLLLDNYSDRIQVL+NMVHCADLSNPTKPL+LYRQWTDRIM EFF+QGDR
Sbjct: 453 VETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDR 512
Query: 381 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWY 440
ERERGMEISPMCDKH ASVEKSQVGFIDYIVHPLWETWADLVHPDAQ+ILDTLEDNR+WY
Sbjct: 513 ERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWY 572
Query: 441 YSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEE---EEISMAQI----PCTAQE 493
S I QSPSP P++ G +KFQFELTLEE+ E E+ S +Q+ C+ +
Sbjct: 573 QSTIPQSPSPAPDDPEE--GRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSK 630
Query: 494 ALTAQGLSGVEEALDATIAWEASPAQE 520
L Q E LD + EA +E
Sbjct: 631 TLCTQDSESTEIPLDEQVEEEAVGEEE 657
>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 736 bits (1900), Expect = 0.0
Identities = 370/460 (80%), Positives = 409/460 (88%), Gaps = 17/460 (3%)
Query: 21 DQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPS 80
++FKRMLNRELTHLSEMSRSGNQVSEYIS TFLDKQN+VEIPSPT K+REK++
Sbjct: 248 NKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ----- 302
Query: 81 QPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNI 140
Q M+QI+G+KKLMHS+SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNI
Sbjct: 303 ----------QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNI 352
Query: 141 FCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAA 200
F V+ Y+ R LTCIMY IFQERDLLK FRI DT +TYM+TLEDHYH+DVAYHNSLHAA
Sbjct: 353 FNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAA 412
Query: 201 DVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 260
DV QSTHVLL+TPALDAVFTDLEILAA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDE
Sbjct: 413 DVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 472
Query: 261 SVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTM 320
SVLENHHLAVGFKLLQE++CDIF NL+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTM
Sbjct: 473 SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTM 532
Query: 321 VETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDR 380
VETKKVTSSGVLLLDNY+DRIQVLRNMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+
Sbjct: 533 VETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDK 592
Query: 381 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWY 440
ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY
Sbjct: 593 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWY 652
Query: 441 YSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE 480
S I QSPSPP +E++R L +KFQFELTL+EE+ E
Sbjct: 653 QSMIPQSPSPPLDEQNR--DCQGLMEKFQFELTLDEEDSE 690
>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
Length = 721
Score = 736 bits (1900), Expect = 0.0
Identities = 370/460 (80%), Positives = 409/460 (88%), Gaps = 17/460 (3%)
Query: 21 DQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPS 80
++FKRMLNRELTHLSEMSRSGNQVSEYIS TFLDKQN+VEIPSPT K+REK++
Sbjct: 233 NKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ----- 287
Query: 81 QPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNI 140
Q M+QI+G+KKLMHS+SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNI
Sbjct: 288 ----------QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNI 337
Query: 141 FCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAA 200
F V+ Y+ R LTCIMY IFQERDLLK FRI DT +TYM+TLEDHYH+DVAYHNSLHAA
Sbjct: 338 FNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAA 397
Query: 201 DVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 260
DV QSTHVLL+TPALDAVFTDLEILAA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDE
Sbjct: 398 DVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 457
Query: 261 SVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTM 320
SVLENHHLAVGFKLLQE++CDIF NL+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTM
Sbjct: 458 SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTM 517
Query: 321 VETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDR 380
VETKKVTSSGVLLLDNY+DRIQVLRNMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+
Sbjct: 518 VETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDK 577
Query: 381 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWY 440
ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY
Sbjct: 578 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWY 637
Query: 441 YSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE 480
S I QSPSPP +E++R L +KFQFELTL+EE+ E
Sbjct: 638 QSMIPQSPSPPLDEQNR--DCQGLMEKFQFELTLDEEDSE 675
>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
Length = 564
Score = 736 bits (1900), Expect = 0.0
Identities = 370/460 (80%), Positives = 409/460 (88%), Gaps = 17/460 (3%)
Query: 21 DQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPS 80
++FKRMLNRELTHLSEMSRSGNQVSEYIS TFLDKQN+VEIPSPT K+REK++
Sbjct: 76 NKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ----- 130
Query: 81 QPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNI 140
Q M+QI+G+KKLMHS+SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNI
Sbjct: 131 ----------QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNI 180
Query: 141 FCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAA 200
F V+ Y+ R LTCIMY IFQERDLLK FRI DT +TYM+TLEDHYH+DVAYHNSLHAA
Sbjct: 181 FNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAA 240
Query: 201 DVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 260
DV QSTHVLL+TPALDAVFTDLEILAA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDE
Sbjct: 241 DVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 300
Query: 261 SVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTM 320
SVLENHHLAVGFKLLQE++CDIF NL+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTM
Sbjct: 301 SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTM 360
Query: 321 VETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDR 380
VETKKVTSSGVLLLDNY+DRIQVLRNMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+
Sbjct: 361 VETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDK 420
Query: 381 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWY 440
ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY
Sbjct: 421 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWY 480
Query: 441 YSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE 480
S I QSPSPP +E++R L +KFQFELTL+EE+ E
Sbjct: 481 QSMIPQSPSPPLDEQNR--DCQGLMEKFQFELTLDEEDSE 518
>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 736 bits (1900), Expect = 0.0
Identities = 370/460 (80%), Positives = 409/460 (88%), Gaps = 17/460 (3%)
Query: 21 DQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPS 80
++FKRMLNRELTHLSEMSRSGNQVSEYIS TFLDKQN+VEIPSPT K+REK++
Sbjct: 248 NKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ----- 302
Query: 81 QPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNI 140
Q M+QI+G+KKLMHS+SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNI
Sbjct: 303 ----------QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNI 352
Query: 141 FCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAA 200
F V+ Y+ R LTCIMY IFQERDLLK FRI DT +TYM+TLEDHYH+DVAYHNSLHAA
Sbjct: 353 FNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAA 412
Query: 201 DVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 260
DV QSTHVLL+TPALDAVFTDLEILAA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDE
Sbjct: 413 DVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 472
Query: 261 SVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTM 320
SVLENHHLAVGFKLLQE++CDIF NL+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTM
Sbjct: 473 SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTM 532
Query: 321 VETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDR 380
VETKKVTSSGVLLLDNY+DRIQVLRNMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+
Sbjct: 533 VETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDK 592
Query: 381 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWY 440
ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY
Sbjct: 593 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWY 652
Query: 441 YSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE 480
S I QSPSPP +E++R L +KFQFELTL+EE+ E
Sbjct: 653 QSMIPQSPSPPLDEQNR--DCQGLMEKFQFELTLDEEDSE 690
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 688 bits (1775), Expect = 0.0
Identities = 354/478 (74%), Positives = 397/478 (83%), Gaps = 29/478 (6%)
Query: 21 DQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPS 80
++FKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q EVE+P T +E AP
Sbjct: 129 NKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEE-----AP----- 178
Query: 81 QPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNI 140
QPMS+I+GL L HS SL+++ +PRFGV+TDQEE LA+ELE+ NKWGL++
Sbjct: 179 ----------QPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDV 228
Query: 141 FCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAA 200
F V++ +G R LT I++ IFQERDLLK F+IP DT+ TY+L LE HYHA+VAYHNSLHAA
Sbjct: 229 FKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAA 288
Query: 201 DVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 260
DV QSTHVLLATPAL+AVFTDLEILAALFA+AIHDVDHPGVSNQFLINTNSELALMYND
Sbjct: 289 DVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDA 348
Query: 261 SVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTM 320
SVLENHHLAVGFKLLQ +NCDIFQNLS +QR SLR+MVIDMVLATDMSKHM LLADLKTM
Sbjct: 349 SVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTM 408
Query: 321 VETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDR 380
VETKKVTS GVLLLDNYSDRIQVL+N+VHCADLSNPTKPL LYRQWTDRIMAEFFQQGDR
Sbjct: 409 VETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDR 468
Query: 381 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWY 440
ERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWETWADLVHPDAQ++LDTLEDNR+WY
Sbjct: 469 ERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWY 528
Query: 441 YSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTL---EEEEEEEISMAQIPCTAQEAL 495
S I +SPS E G PD+FQFELTL EEE+EEE + A+EAL
Sbjct: 529 QSKIPRSPSDLTNPERDG------PDRFQFELTLEEAEEEDEEEEEEGEETALAKEAL 580
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 688 bits (1775), Expect = 0.0
Identities = 354/478 (74%), Positives = 397/478 (83%), Gaps = 29/478 (6%)
Query: 21 DQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPS 80
++FKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q EVE+P T +E AP
Sbjct: 203 NKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEE-----AP----- 252
Query: 81 QPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNI 140
QPMS+I+GL L HS SL+++ +PRFGV+TDQEE LA+ELE+ NKWGL++
Sbjct: 253 ----------QPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDV 302
Query: 141 FCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAA 200
F V++ +G R LT I++ IFQERDLLK F+IP DT+ TY+L LE HYHA+VAYHNSLHAA
Sbjct: 303 FKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAA 362
Query: 201 DVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 260
DV QSTHVLLATPAL+AVFTDLEILAALFA+AIHDVDHPGVSNQFLINTNSELALMYND
Sbjct: 363 DVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDA 422
Query: 261 SVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTM 320
SVLENHHLAVGFKLLQ +NCDIFQNLS +QR SLR+MVIDMVLATDMSKHM LLADLKTM
Sbjct: 423 SVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTM 482
Query: 321 VETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDR 380
VETKKVTS GVLLLDNYSDRIQVL+N+VHCADLSNPTKPL LYRQWTDRIMAEFFQQGDR
Sbjct: 483 VETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDR 542
Query: 381 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWY 440
ERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWETWADLVHPDAQ++LDTLEDNR+WY
Sbjct: 543 ERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWY 602
Query: 441 YSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTL---EEEEEEEISMAQIPCTAQEAL 495
S I +SPS E G PD+FQFELTL EEE+EEE + A+EAL
Sbjct: 603 QSKIPRSPSDLTNPERDG------PDRFQFELTLEEAEEEDEEEEEEGEETALAKEAL 654
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 688 bits (1775), Expect = 0.0
Identities = 354/478 (74%), Positives = 397/478 (83%), Gaps = 29/478 (6%)
Query: 21 DQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPS 80
++FKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q EVE+P T +E AP
Sbjct: 235 NKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEE-----AP----- 284
Query: 81 QPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNI 140
QPMS+I+GL L HS SL+++ +PRFGV+TDQEE LA+ELE+ NKWGL++
Sbjct: 285 ----------QPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDV 334
Query: 141 FCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAA 200
F V++ +G R LT I++ IFQERDLLK F+IP DT+ TY+L LE HYHA+VAYHNSLHAA
Sbjct: 335 FKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAA 394
Query: 201 DVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 260
DV QSTHVLLATPAL+AVFTDLEILAALFA+AIHDVDHPGVSNQFLINTNSELALMYND
Sbjct: 395 DVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDA 454
Query: 261 SVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTM 320
SVLENHHLAVGFKLLQ +NCDIFQNLS +QR SLR+MVIDMVLATDMSKHM LLADLKTM
Sbjct: 455 SVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTM 514
Query: 321 VETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDR 380
VETKKVTS GVLLLDNYSDRIQVL+N+VHCADLSNPTKPL LYRQWTDRIMAEFFQQGDR
Sbjct: 515 VETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDR 574
Query: 381 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWY 440
ERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWETWADLVHPDAQ++LDTLEDNR+WY
Sbjct: 575 ERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWY 634
Query: 441 YSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTL---EEEEEEEISMAQIPCTAQEAL 495
S I +SPS E G PD+FQFELTL EEE+EEE + A+EAL
Sbjct: 635 QSKIPRSPSDLTNPERDG------PDRFQFELTLEEAEEEDEEEEEEGEETALAKEAL 686
>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
Length = 535
Score = 237 bits (605), Expect = 2e-62
Identities = 117/292 (40%), Positives = 187/292 (64%), Gaps = 12/292 (4%)
Query: 130 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 189
L++++KW ++F +++ +G SL ++Y +F DL+ +F+IPV ++T+ LE Y
Sbjct: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
Query: 190 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 248
YHN +HAADV Q+ H ++ + T+LEILA +FAAAIHD +H G +N F I
Sbjct: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
Query: 249 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 308
T S++A++YND SVLENHH++ ++L+QE+ +I NLSK + LR +VI+MVL+TDMS
Sbjct: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
Query: 309 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 368
H + +++ ++ + G+ DR + + ++H AD+S+P K +L+ +WT
Sbjct: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
Query: 369 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 420
+M EFF QGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D
Sbjct: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
Length = 545
Score = 237 bits (605), Expect = 2e-62
Identities = 117/292 (40%), Positives = 187/292 (64%), Gaps = 12/292 (4%)
Query: 130 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 189
L++++KW ++F +++ +G SL ++Y +F DL+ +F+IPV ++T+ LE Y
Sbjct: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
Query: 190 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 248
YHN +HAADV Q+ H ++ + T+LEILA +FAAAIHD +H G +N F I
Sbjct: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
Query: 249 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 308
T S++A++YND SVLENHH++ ++L+QE+ +I NLSK + LR +VI+MVL+TDMS
Sbjct: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
Query: 309 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 368
H + +++ ++ + G+ DR + + ++H AD+S+P K +L+ +WT
Sbjct: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
Query: 369 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 420
+M EFF QGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D
Sbjct: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
>gi|4826894 phosphodiesterase 1C [Homo sapiens]
Length = 634
Score = 234 bits (598), Expect = 1e-61
Identities = 119/306 (38%), Positives = 187/306 (61%), Gaps = 13/306 (4%)
Query: 128 QELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHY 187
+ L++++KW ++F +++ +G +L I Y + DL+ +F+IP+ +V+++ LE Y
Sbjct: 161 EALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGY 220
Query: 188 HADV-AYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFL 246
YHN +HAADV Q+ H LL + T+LEI A +F+AAIHD +H G +N F
Sbjct: 221 SKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFH 280
Query: 247 INTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVIDMVLAT 305
I T S+ A++YND SVLENHHL+ ++LLQ+D +I NLSK + R +VI+MV+AT
Sbjct: 281 IQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMAT 340
Query: 306 DMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQ 365
DMS H + +KT ++ + ++ + L M+H AD+S+P K +L+ +
Sbjct: 341 DMSCHFQQIKAMKTALQQPEAI-----------EKPKALSLMLHTADISHPAKAWDLHHR 389
Query: 366 WTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPD 425
WT ++ EFF+QGDRE E G+ SP+CD+ + V +SQVGFID+IV P + D+
Sbjct: 390 WTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKI 449
Query: 426 AQEILD 431
++D
Sbjct: 450 VSPLID 455
>gi|4505677 phosphodiesterase 1B [Homo sapiens]
Length = 536
Score = 231 bits (590), Expect = 1e-60
Identities = 119/309 (38%), Positives = 189/309 (61%), Gaps = 14/309 (4%)
Query: 130 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 189
L+NL+ W ++F ++ A +L I++ + +L+ +F+IP +++++ LE Y
Sbjct: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
Query: 190 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 248
YHN +HAADV Q+ H L + +++E+LA +FAAAIHD +H G +N F I
Sbjct: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
Query: 249 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 308
T SE A++YND SVLENHH++ F+L+Q+D +IF NL+K + LR +VI+MVLATDMS
Sbjct: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
Query: 309 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 368
H + +KT ++ + D+ + L ++H AD+S+PTK ++ +WT
Sbjct: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
Query: 369 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQE 428
+M EFF+QGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D+ Q
Sbjct: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
Query: 429 ILDTLEDNR 437
+ D ED++
Sbjct: 447 LAD--EDSK 453
>gi|9506959 phosphodiesterase 7B [Homo sapiens]
Length = 450
Score = 216 bits (549), Expect = 7e-56
Identities = 126/393 (32%), Positives = 208/393 (52%), Gaps = 20/393 (5%)
Query: 93 MSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNK---WGLNIFCVSDYAGG 149
+ ++ ++ H++ L IP+ + E+ L Q L+K W +IF G
Sbjct: 69 VKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNG 128
Query: 150 RSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVL 209
SL ++ +F L+ F++ + T+ +++ +++ YH+ YHN++HAADV Q+ H
Sbjct: 129 NSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCY 188
Query: 210 LATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLA 269
L P L + T L+I+ L AAA HDVDHPGV+ FLI TN LA +Y + SVLENHH
Sbjct: 189 LKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWR 248
Query: 270 VGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSS 329
+L+E + +L K Q + + + ++LATD+++ L LK + K
Sbjct: 249 STIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKD---- 302
Query: 330 GVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEIS 389
L L++ DR +L+ + CAD+ NP + E+ +QW++R+ EF++QG+ E++ +EIS
Sbjct: 303 --LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS 360
Query: 390 PMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPD--AQEILDTLEDNRDWYYSAIRQS 447
P+C++ S+ Q+GF+ YIV PL+ WA ++ +L L N+ + S +
Sbjct: 361 PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLL--- 417
Query: 448 PSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE 480
P + SRG PD E EE+E
Sbjct: 418 ---PRQHRSRGSSGSG-PDHDHAGQGTESEEQE 446
>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
Length = 783
Score = 214 bits (545), Expect = 2e-55
Identities = 119/344 (34%), Positives = 194/344 (56%), Gaps = 18/344 (5%)
Query: 126 LAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLED 185
+A+ +EN W +IF + R L + +F + + T+ +++ +E
Sbjct: 442 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 501
Query: 186 HYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQF 245
+YH+ YHNS H+ADVL +T L+ + ++ +AAL AA IHDVDHPG +N F
Sbjct: 502 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 561
Query: 246 LINTNSELALMYNDESVLENHHLAVGFKLLQ-EDNCDIFQNLSKRQRQSLRKMVIDMVLA 304
L N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +IDMVLA
Sbjct: 562 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 621
Query: 305 TDMSKHM-----------TLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADL 353
T+M+KH LA L+ ET K +L +R + R ++ CAD+
Sbjct: 622 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 681
Query: 354 SNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDYIVH 412
SNP +PL+ +W RI E+F Q D E+++G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 682 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 741
Query: 413 PLWETWADLVHPDAQEILDTLEDNRDWYYSAIR---QSPSPPPE 453
+++ W V D +++ L++N ++ ++ PPPE
Sbjct: 742 DMFDAWDAFV--DLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE 783
>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
Length = 829
Score = 214 bits (545), Expect = 2e-55
Identities = 119/344 (34%), Positives = 194/344 (56%), Gaps = 18/344 (5%)
Query: 126 LAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLED 185
+A+ +EN W +IF + R L + +F + + T+ +++ +E
Sbjct: 488 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 547
Query: 186 HYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQF 245
+YH+ YHNS H+ADVL +T L+ + ++ +AAL AA IHDVDHPG +N F
Sbjct: 548 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 607
Query: 246 LINTNSELALMYNDESVLENHHLAVGFKLLQ-EDNCDIFQNLSKRQRQSLRKMVIDMVLA 304
L N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +IDMVLA
Sbjct: 608 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 667
Query: 305 TDMSKHM-----------TLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADL 353
T+M+KH LA L+ ET K +L +R + R ++ CAD+
Sbjct: 668 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 727
Query: 354 SNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDYIVH 412
SNP +PL+ +W RI E+F Q D E+++G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 728 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 787
Query: 413 PLWETWADLVHPDAQEILDTLEDNRDWYYSAIR---QSPSPPPE 453
+++ W V D +++ L++N ++ ++ PPPE
Sbjct: 788 DMFDAWDAFV--DLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE 829
>gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
Length = 838
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 121 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 180
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 495 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 554
Query: 181 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 240
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 555 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 614
Query: 241 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 299
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 615 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 674
Query: 300 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 350
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 675 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 732
Query: 351 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 409
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 733 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 792
Query: 410 IVHPLWETWADLVHPDAQEILDTLEDN 436
+ +++ W H A ++ L DN
Sbjct: 793 FITDMFDAWDAFAHLPA--LMQHLADN 817
>gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]
Length = 865
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 121 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 180
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 522 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 581
Query: 181 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 240
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 582 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 641
Query: 241 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 299
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 642 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 701
Query: 300 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 350
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 702 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 759
Query: 351 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 409
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 760 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 819
Query: 410 IVHPLWETWADLVHPDAQEILDTLEDN 436
+ +++ W H A ++ L DN
Sbjct: 820 FITDMFDAWDAFAHLPA--LMQHLADN 844
>gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]
Length = 830
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 121 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 180
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 487 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 546
Query: 181 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 240
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 547 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 606
Query: 241 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 299
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 607 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 666
Query: 300 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 350
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 667 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 724
Query: 351 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 409
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 725 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 784
Query: 410 IVHPLWETWADLVHPDAQEILDTLEDN 436
+ +++ W H A ++ L DN
Sbjct: 785 FITDMFDAWDAFAHLPA--LMQHLADN 809
>gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]
Length = 788
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 121 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 180
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 445 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 504
Query: 181 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 240
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 505 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 564
Query: 241 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 299
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 565 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 624
Query: 300 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 350
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 625 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 682
Query: 351 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 409
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 683 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 742
Query: 410 IVHPLWETWADLVHPDAQEILDTLEDN 436
+ +++ W H A ++ L DN
Sbjct: 743 FITDMFDAWDAFAHLPA--LMQHLADN 767
>gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]
Length = 885
Score = 211 bits (537), Expect = 2e-54
Identities = 118/327 (36%), Positives = 185/327 (56%), Gaps = 15/327 (4%)
Query: 121 DQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYM 180
D ++Q L+N W NIF + R L + +F + + T+ +
Sbjct: 542 DVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWF 601
Query: 181 LTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPG 240
+E +YH+ AYHNS HAADVL +T L + L+ +AAL AA +HDVDHPG
Sbjct: 602 QVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPG 661
Query: 241 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQED-NCDIFQNLSKRQRQSLRKMVI 299
+N FL N SELA++YND +VLE+HH A+ F+L +D C+IF+N+ + ++LR+ +I
Sbjct: 662 RTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAII 721
Query: 300 DMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLD--------NY-SDRIQVLRNMVHC 350
DMVLAT+M+KH + K + K ++ + D N+ ++I + R M+ C
Sbjct: 722 DMVLATEMTKHFEHVN--KFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKC 779
Query: 351 ADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME-ISPMCDKHTASVEKSQVGFIDY 409
AD++NP +PL+L +W RI E+F Q D E+ +G+ + P+ D++T S+ KSQ+ FIDY
Sbjct: 780 ADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDY 839
Query: 410 IVHPLWETWADLVHPDAQEILDTLEDN 436
+ +++ W H A ++ L DN
Sbjct: 840 FITDMFDAWDAFAHLPA--LMQHLADN 864
>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
Length = 456
Score = 209 bits (533), Expect = 5e-54
Identities = 106/290 (36%), Positives = 168/290 (57%), Gaps = 8/290 (2%)
Query: 130 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 189
LE + W +IF G SL + + +F L++ F + + + +++ +++ YH+
Sbjct: 122 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 181
Query: 190 DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINT 249
YHN++HAADV Q+ H L P L T +IL +L AAA HD+DHPGV+ FLI T
Sbjct: 182 QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 241
Query: 250 NSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSK 309
N LA +Y + SVLENHH LL+E +F +L RQ + + ++LATD+S+
Sbjct: 242 NHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISR 299
Query: 310 HMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDR 369
L+ ++ ++ G L L++ R VL+ + CAD+ NP + EL +QW+++
Sbjct: 300 QNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEK 353
Query: 370 IMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWA 419
+ EFF QGD E++ + +SP+CD+HT S+ Q+GF+ Y+V PL+ WA
Sbjct: 354 VTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
>gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]
Length = 424
Score = 194 bits (493), Expect = 2e-49
Identities = 100/281 (35%), Positives = 160/281 (56%), Gaps = 8/281 (2%)
Query: 130 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 189
LE + W +IF G SL + + +F L++ F + + + +++ +++ YH+
Sbjct: 148 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 207
Query: 190 DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINT 249
YHN++HAADV Q+ H L P L T +IL +L AAA HD+DHPGV+ FLI T
Sbjct: 208 QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKT 267
Query: 250 NSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSK 309
N LA +Y + SVLENHH LL+E +F +L RQ + + ++LATD+S+
Sbjct: 268 NHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGALILATDISR 325
Query: 310 HMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDR 369
L+ ++ ++ G L L++ R VL+ + CAD+ NP + EL +QW+++
Sbjct: 326 QNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEK 379
Query: 370 IMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYI 410
+ EFF QGD E++ + +SP+CD+HT S+ Q+G Y+
Sbjct: 380 VTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGNYTYL 420
>gi|40254434 phosphodiesterase 3B [Homo sapiens]
Length = 1112
Score = 178 bits (451), Expect = 2e-44
Identities = 110/337 (32%), Positives = 168/337 (49%), Gaps = 52/337 (15%)
Query: 130 LENLNKWGLNIFCVSDYAG---GRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDH 186
+E ++ W IF + + G GR L+ +MY +FQ+ LL+ F+IP + Y LE+
Sbjct: 671 IEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENG 730
Query: 187 YHADVAYHNSLHAADVLQSTHVLLATPA-------------------------------- 214
Y D+ YHN +HA DVL + L P
Sbjct: 731 YR-DIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISS 789
Query: 215 ------------LDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESV 262
L + LE++A AAA+HD DHPG +N FL+ TN+ A++YND SV
Sbjct: 790 KSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSV 849
Query: 263 LENHHLAVGFKL-LQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMV 321
LENHH A + L L + +L + + R +VI+ +LATD+ KH LA+
Sbjct: 850 LENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNA-- 907
Query: 322 ETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRE 381
+ V S+G+ N +DR+ V + + AD++ P K +L+ +WT+ I+ EF++QGD E
Sbjct: 908 KANDVNSNGIEW-SNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEE 966
Query: 382 RERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETW 418
G+ ISP D+ + + K Q FI +IV PL ++
Sbjct: 967 ANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSY 1003
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 177 bits (448), Expect = 4e-44
Identities = 101/328 (30%), Positives = 179/328 (54%), Gaps = 14/328 (4%)
Query: 114 PRFGVKTDQEELLAQE-LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIP 172
PR V T + LL+ E +E L K +++ + L+C+ +M + + L++ F I
Sbjct: 29 PRRDVPTYPKYLLSPETIEALRKPTFDVWL---WEPNEMLSCLEHM-YHDLGLVRDFSIN 84
Query: 173 VDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAA 232
T+ ++ + D+Y + +HN H V Q + ++ +L F+ +IL + AA
Sbjct: 85 PVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAI 143
Query: 233 IHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQ 292
HD+DHPG +N + IN +ELA+ YND S LENHH AV F++L E C+IF N+ +
Sbjct: 144 CHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFK 203
Query: 293 SLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCAD 352
+R+ +I ++LATDM++H ++ K +E ++ + L + ++ C D
Sbjct: 204 QIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTL--------LKMILIKCCD 255
Query: 353 LSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVH 412
+SN +P+E+ W D ++ E+F Q DRE+ G+ ++P D+ + +Q+GFI +++
Sbjct: 256 ISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLI 315
Query: 413 PLWETWADLVHPDAQEILDTLEDNRDWY 440
P++ET L + +L L ++RD Y
Sbjct: 316 PMFETVTKLFPMVEEIMLQPLWESRDRY 343
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 177 bits (448), Expect = 4e-44
Identities = 101/328 (30%), Positives = 179/328 (54%), Gaps = 14/328 (4%)
Query: 114 PRFGVKTDQEELLAQE-LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIP 172
PR V T + LL+ E +E L K +++ + L+C+ +M + + L++ F I
Sbjct: 29 PRRDVPTYPKYLLSPETIEALRKPTFDVWL---WEPNEMLSCLEHM-YHDLGLVRDFSIN 84
Query: 173 VDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAA 232
T+ ++ + D+Y + +HN H V Q + ++ +L F+ +IL + AA
Sbjct: 85 PVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAI 143
Query: 233 IHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQ 292
HD+DHPG +N + IN +ELA+ YND S LENHH AV F++L E C+IF N+ +
Sbjct: 144 CHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFK 203
Query: 293 SLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCAD 352
+R+ +I ++LATDM++H ++ K +E ++ + L + ++ C D
Sbjct: 204 QIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTL--------LKMILIKCCD 255
Query: 353 LSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVH 412
+SN +P+E+ W D ++ E+F Q DRE+ G+ ++P D+ + +Q+GFI +++
Sbjct: 256 ISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLI 315
Query: 413 PLWETWADLVHPDAQEILDTLEDNRDWY 440
P++ET L + +L L ++RD Y
Sbjct: 316 PMFETVTKLFPMVEEIMLQPLWESRDRY 343
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,499,515
Number of Sequences: 37866
Number of extensions: 1417190
Number of successful extensions: 16293
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 160
Number of HSP's successfully gapped in prelim test: 170
Number of HSP's that attempted gapping in prelim test: 14164
Number of HSP's gapped (non-prelim): 1861
length of query: 647
length of database: 18,247,518
effective HSP length: 109
effective length of query: 538
effective length of database: 14,120,124
effective search space: 7596626712
effective search space used: 7596626712
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.