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Search of human proteins with 54292117
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|54292117 ADAM metallopeptidase domain 28 isoform 3
preproprotein [Homo sapiens]
(540 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprot... 1141 0.0
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot... 1102 0.0
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ... 433 e-121
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens] 404 e-113
gi|7657319 ADAM-like, decysin 1 isoform 1 [Homo sapiens] 392 e-109
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ... 370 e-102
gi|223671932 ADAM-like, decysin 1 isoform 2 [Homo sapiens] 353 2e-97
gi|223671930 ADAM-like, decysin 1 isoform 2 [Homo sapiens] 353 2e-97
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot... 351 8e-97
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot... 351 8e-97
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro... 341 1e-93
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop... 341 1e-93
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H... 333 2e-91
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor... 313 3e-85
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor... 313 3e-85
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor... 313 3e-85
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor... 313 3e-85
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor... 313 3e-85
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor... 313 3e-85
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ... 254 1e-67
gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo sapi... 251 9e-67
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo... 242 5e-64
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo... 242 5e-64
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo... 242 5e-64
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ... 242 5e-64
gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo s... 239 5e-63
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot... 237 2e-62
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot... 237 2e-62
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot... 237 2e-62
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot... 237 2e-62
>gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprotein
[Homo sapiens]
Length = 540
Score = 1141 bits (2952), Expect = 0.0
Identities = 540/540 (100%), Positives = 540/540 (100%)
Query: 1 MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYK 60
MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYK
Sbjct: 1 MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYK 60
Query: 61 MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS 120
MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS
Sbjct: 61 MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS 120
Query: 121 ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDL 180
ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDL
Sbjct: 121 ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDL 180
Query: 181 QQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNM 240
QQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNM
Sbjct: 181 QQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNM 240
Query: 241 LYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATE 300
LYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATE
Sbjct: 241 LYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATE 300
Query: 301 LAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTI 360
LAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTI
Sbjct: 301 LAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTI 360
Query: 361 CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGED 420
CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGED
Sbjct: 361 CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGED 420
Query: 421 CDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNG 480
CDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNG
Sbjct: 421 CDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNG 480
Query: 481 KSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGRRTNPFPCACAKENHFR 540
KSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGRRTNPFPCACAKENHFR
Sbjct: 481 KSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGRRTNPFPCACAKENHFR 540
>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
[Homo sapiens]
Length = 775
Score = 1102 bits (2851), Expect = 0.0
Identities = 524/531 (98%), Positives = 524/531 (98%)
Query: 1 MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYK 60
MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYK
Sbjct: 1 MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYK 60
Query: 61 MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS 120
MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS
Sbjct: 61 MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS 120
Query: 121 ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDL 180
ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDL
Sbjct: 121 ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDL 180
Query: 181 QQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNM 240
QQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNM
Sbjct: 181 QQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNM 240
Query: 241 LYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATE 300
LYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATE
Sbjct: 241 LYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATE 300
Query: 301 LAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTI 360
LAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTI
Sbjct: 301 LAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTI 360
Query: 361 CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGED 420
CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGED
Sbjct: 361 CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGED 420
Query: 421 CDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNG 480
CDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNG
Sbjct: 421 CDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNG 480
Query: 481 KSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGRRTNPFPC 531
KSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPG C
Sbjct: 481 KSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSC 531
>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
sapiens]
Length = 754
Score = 433 bits (1113), Expect = e-121
Identities = 225/530 (42%), Positives = 315/530 (59%), Gaps = 25/530 (4%)
Query: 1 MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQE---QFETEL 57
ML G + + +LL V K + GV+ ++V P +L + KR+ + +E EL
Sbjct: 1 MLPGCIFLMILLIPQVKE-KFILGVEGQQLVRPKKLPLIQKRDTGHTHDDDILKTYEEEL 59
Query: 58 KYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVS 117
Y++ +N K VL+L +++ L Y+ET+Y+ G+ T PQIMD C+YQG I++E S
Sbjct: 60 LYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDS 119
Query: 118 DASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYN---PDEKNYDSTCGMDGV 174
ASISTC GLRG+F DQRY IEP+ + D EH +FKYN P NY T
Sbjct: 120 AASISTCNGLRGFFRINDQRYLIEPVK--YSDEGEHLVFKYNLRVPYGANYSCT------ 171
Query: 175 LWAHDLQQNIALPATKLVKLKDRKVQ--EHEKYIEYYLVLDNGEFKRYNENQDEIRKRVF 232
+L +D K++ EKY+E ++V D+ ++R +++R R++
Sbjct: 172 ----ELNFTRKTVPGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIW 227
Query: 233 EMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDI 292
M N+VNM+YK LN HV LVG+EIWT +DKI++ N TL FS W+ +L RK D
Sbjct: 228 GMVNFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDH 287
Query: 293 AQLITATELAGTTVGLAFMSTMCSPY-SVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDD 351
L++ L G+++ MC PY S +++D + +A MAH++GHN GM HD+
Sbjct: 288 VVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDE 347
Query: 352 YSCKCPSTICVMDKALSFYIPT-DFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPIC 410
+ C CPS CVMD S IP FS CS+ Y ++ +D C+ N P P + C
Sbjct: 348 FPCTCPSGKCVMDSDGS--IPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFC 405
Query: 411 GNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKD 470
GN+ ++ GE+CDCG ++ECTN CCDA TC +K F CA GECCE CQ KKAG +CRPAKD
Sbjct: 406 GNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKD 465
Query: 471 ECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELW 520
ECD PEMC G S CP D+F+VNGFPC + +G+C MG CPT ++QC+EL+
Sbjct: 466 ECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELF 515
>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
Length = 856
Score = 404 bits (1039), Expect = e-113
Identities = 219/537 (40%), Positives = 301/537 (56%), Gaps = 20/537 (3%)
Query: 4 GLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYKMTI 63
GL + ++ A++ + +++YEVV P RL R A P + Y +
Sbjct: 5 GLWLLGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRAL-PSHLGLHPERVSYVLGA 63
Query: 64 NGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASIST 123
G L+L+KN++LL GYTETY + G E+T P+ D C+YQGH+ S AS+ST
Sbjct: 64 TGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLST 123
Query: 124 CRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDLQQN 183
C GLRG+F G + IEPL +G HA+++ ++ T G GV + D +
Sbjct: 124 CAGLRGFFQVGSDLHLIEPLDE-GGEGGRHAVYQ----AEHLLQTAGTCGV--SDDSLGS 176
Query: 184 IALPATKLV---KLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNM 240
+ P T V + D +Y+E Y+V+DN EF+ ++ +R RV E+ N+V+
Sbjct: 177 LLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLG-SEAAVRHRVLEVVNHVDK 235
Query: 241 LYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATE 300
LY+KLN V LVG+EIW +D+ ++P+ S TLEN W+ +RR HD QLIT +
Sbjct: 236 LYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVD 295
Query: 301 LAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDD--YSCKCPS 358
GTTVG A +S MCS S V QDHS N + VA TMAHEMGHN GM HD+ C+C
Sbjct: 296 FTGTTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQE 355
Query: 359 TI----CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQL 414
C+M ++ P FS CS+ + F E S CL NAP + ++ P+CGN
Sbjct: 356 RFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLF 415
Query: 415 VEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDL 474
VE GE CDCG E+C N CC++ TC++ QCA G CC++C+ K AG +CRP KD CDL
Sbjct: 416 VERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDL 475
Query: 475 PEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGRRTNPFPC 531
E C+G+ CP+D FQ NG PC G+C G CPTL +QC WGPG + C
Sbjct: 476 EEFCDGRHPECPEDAFQENGTPC--SGGYCYNGACPTLAQQCQAFWGPGGQAAEESC 530
>gi|7657319 ADAM-like, decysin 1 isoform 1 [Homo sapiens]
Length = 470
Score = 392 bits (1006), Expect = e-109
Identities = 203/450 (45%), Positives = 290/450 (64%), Gaps = 14/450 (3%)
Query: 5 LLPVS-LLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPE-----QQEQFETELK 58
LLPV L++ AIK+ P + +E+V P +LH LHKRE K + ++E++E E++
Sbjct: 18 LLPVLWLIVQTQAIAIKQTPELTLHEIVCPKKLHILHKREIKNNQTEKHGKEERYEPEVQ 77
Query: 59 YKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSD 118
Y+M +NG+ +L L+K K+LL P YTET Y+ G+EITT P+ M+ CYY+G+ILNEK S
Sbjct: 78 YQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSV 137
Query: 119 ASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKN-YDSTCGMDGVLWA 177
ASISTC GLRGYF+ QRY I+PL D +EHA+F N +E++ + TCG+
Sbjct: 138 ASISTCDGLRGYFTHHHQRYQIKPLKST--DEKEHAVFTSNQEEQDPANHTCGVKST--- 192
Query: 178 HDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANY 237
D +Q + L + +KYI+ YLVLDN +K YNEN IR VF++ N
Sbjct: 193 -DGKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNL 251
Query: 238 VNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLIT 297
+N++Y ++ VALVGMEIW+D DKIK+ P+AS T +NF +W S L + K HD AQL++
Sbjct: 252 LNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGK-KIHDHAQLLS 310
Query: 298 ATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCP 357
VGLA +++CSP SV V++ N + + G M+HE+GH GM ++ KCP
Sbjct: 311 GISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCP 370
Query: 358 STICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEM 417
S CVM++ LS P DFS+ R ++++ + CL AP+PT+I++TP+CGN L+E+
Sbjct: 371 SGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEV 430
Query: 418 GEDCDCGTSEECTNICCDAKTCKIKATFQC 447
GEDCDCG+ +ECTN+CC+A TCK+K C
Sbjct: 431 GEDCDCGSPKECTNLCCEALTCKLKPGTDC 460
>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
sapiens]
Length = 918
Score = 370 bits (951), Expect = e-102
Identities = 193/498 (38%), Positives = 280/498 (56%), Gaps = 17/498 (3%)
Query: 43 EAKEPEQQEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIM 102
+ E +E+ + + ++ G+ +L L+KN+ L AP YTET+Y S+G TT+ ++
Sbjct: 51 KTSESPVREKHPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLE 110
Query: 103 DDCYYQGHILNEKVSDASISTCRGLRGYFS-QGDQRYFIEPLSPIHRDGQEHALFKYNPD 161
D C+Y G + ++S ++STCRG+RG + + Y IEPL D + L +
Sbjct: 111 DHCFYHGTVRETELSSVTLSTCRGIRGLITVSSNLSYVIEPLP----DSKGQHLIYRSEH 166
Query: 162 EKNYDSTCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHE----KYIEYYLVLDNGEF 217
K CG + + ++ AL T+ K + R+++ + KY+E YLV D EF
Sbjct: 167 LKPPPGNCGFEH---SKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEF 223
Query: 218 KRYNENQDEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFS 277
++ +QD + ++ E+ANYV+ Y+ LN +ALVG+E+WT + +++ N TL +F
Sbjct: 224 QKNRRDQDATKHKLIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFL 283
Query: 278 KWRGSVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPY-SVGVVQDHSDNLLRVAGT 336
WR +L++ K HD AQLIT GTT+GLA + MCS Y S GV DHS+N + VA T
Sbjct: 284 SWRRKLLAQ-KYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAAT 342
Query: 337 MAHEMGHNFGMFHDDYSCKCPSTI---CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSN 393
MAHEMGHNFGM HD C S C+M A P F+ C+R D++ +
Sbjct: 343 MAHEMGHNFGMTHDSADCCSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGM 402
Query: 394 CLFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECC 453
CL N P + CGN +E GE+CDCG EEC N CC+A C ++ +CA G CC
Sbjct: 403 CLSNMPDTRMLYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCC 462
Query: 454 EKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQ 513
+C+ G +CR +CDLPE C GKS +CP + +Q++G PC G+ +C G C T Q
Sbjct: 463 HQCKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQ 522
Query: 514 EQCTELWGPGRRTNPFPC 531
EQC +LWGPG R P C
Sbjct: 523 EQCQQLWGPGARPAPDLC 540
>gi|223671932 ADAM-like, decysin 1 isoform 2 [Homo sapiens]
Length = 391
Score = 353 bits (907), Expect = 2e-97
Identities = 179/388 (46%), Positives = 251/388 (64%), Gaps = 8/388 (2%)
Query: 61 MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS 120
M +NG+ +L L+K K+LL P YTET Y+ G+EITT P+ M+ CYY+G+ILNEK S AS
Sbjct: 1 MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS 60
Query: 121 ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKN-YDSTCGMDGVLWAHD 179
ISTC GLRGYF+ QRY I+PL D +EHA+F N +E++ + TCG+ D
Sbjct: 61 ISTCDGLRGYFTHHHQRYQIKPLKST--DEKEHAVFTSNQEEQDPANHTCGVKST----D 114
Query: 180 LQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVN 239
+Q + L + +KYI+ YLVLDN +K YNEN IR VF++ N +N
Sbjct: 115 GKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLN 174
Query: 240 MLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITAT 299
++Y ++ VALVGMEIW+D DKIK+ P+AS T +NF +W S L + K HD AQL++
Sbjct: 175 VIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGK-KIHDHAQLLSGI 233
Query: 300 ELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPST 359
VGLA +++CSP SV V++ N + + G M+HE+GH GM ++ KCPS
Sbjct: 234 SFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSG 293
Query: 360 ICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGE 419
CVM++ LS P DFS+ R ++++ + CL AP+PT+I++TP+CGN L+E+GE
Sbjct: 294 SCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGE 353
Query: 420 DCDCGTSEECTNICCDAKTCKIKATFQC 447
DCDCG+ +ECTN+CC+A TCK+K C
Sbjct: 354 DCDCGSPKECTNLCCEALTCKLKPGTDC 381
>gi|223671930 ADAM-like, decysin 1 isoform 2 [Homo sapiens]
Length = 391
Score = 353 bits (907), Expect = 2e-97
Identities = 179/388 (46%), Positives = 251/388 (64%), Gaps = 8/388 (2%)
Query: 61 MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS 120
M +NG+ +L L+K K+LL P YTET Y+ G+EITT P+ M+ CYY+G+ILNEK S AS
Sbjct: 1 MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS 60
Query: 121 ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKN-YDSTCGMDGVLWAHD 179
ISTC GLRGYF+ QRY I+PL D +EHA+F N +E++ + TCG+ D
Sbjct: 61 ISTCDGLRGYFTHHHQRYQIKPLKST--DEKEHAVFTSNQEEQDPANHTCGVKST----D 114
Query: 180 LQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVN 239
+Q + L + +KYI+ YLVLDN +K YNEN IR VF++ N +N
Sbjct: 115 GKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLN 174
Query: 240 MLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITAT 299
++Y ++ VALVGMEIW+D DKIK+ P+AS T +NF +W S L + K HD AQL++
Sbjct: 175 VIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGK-KIHDHAQLLSGI 233
Query: 300 ELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPST 359
VGLA +++CSP SV V++ N + + G M+HE+GH GM ++ KCPS
Sbjct: 234 SFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSG 293
Query: 360 ICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGE 419
CVM++ LS P DFS+ R ++++ + CL AP+PT+I++TP+CGN L+E+GE
Sbjct: 294 SCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGE 353
Query: 420 DCDCGTSEECTNICCDAKTCKIKATFQC 447
DCDCG+ +ECTN+CC+A TCK+K C
Sbjct: 354 DCDCGSPKECTNLCCEALTCKLKPGTDC 381
>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
[Homo sapiens]
Length = 738
Score = 351 bits (901), Expect = 8e-97
Identities = 185/494 (37%), Positives = 271/494 (54%), Gaps = 32/494 (6%)
Query: 57 LKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQ---IMDDCYYQGHILN 113
L ++ K ++ L++N+ L+A +TET+Y G +++ + I+ CYY GH+
Sbjct: 68 LNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRG 127
Query: 114 EKVSDASISTCRGLRGYFSQGDQRYFIEPL-SPIHRDGQEHALFKYNPDEK--NYDSTCG 170
S S+STC GLRG ++ Y +EP+ S +R +K P +K + +CG
Sbjct: 128 YSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR-------YKLFPAKKLKSVRGSCG 180
Query: 171 MDGVLWAHDLQQNIAL------PATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQ 224
+H N+A P+ + R+ + KY+E +V DN EF+R ++
Sbjct: 181 ------SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234
Query: 225 DEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVL 284
+++++R+ E+AN+V+ Y+ LN + LVG+E+W D DK ++ + +L F WR L
Sbjct: 235 EKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKL 294
Query: 285 SRRKRHDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGH 343
RK HD AQL++ GTT+G+A + +MC+ S G+V DHSDN L A T+AHE+GH
Sbjct: 295 LPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGH 354
Query: 344 NFGMFHD--DYSCKCPSTI----CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFN 397
NFGM HD D C C + C+M+ + + P FSSCSR + E + CLFN
Sbjct: 355 NFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFN 414
Query: 398 APLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQ 457
P + CGN+ VE GE+CDCG EEC N CC+A TC +K CA G CCE CQ
Sbjct: 415 LPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQ 474
Query: 458 FKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCT 517
K AG CR + + CDLPE C G S +CP + + +G C G+C G C T ++QC
Sbjct: 475 LKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCV 534
Query: 518 ELWGPGRRTNPFPC 531
LWGPG + P C
Sbjct: 535 TLWGPGAKPAPGIC 548
>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
[Homo sapiens]
Length = 909
Score = 351 bits (901), Expect = 8e-97
Identities = 185/494 (37%), Positives = 271/494 (54%), Gaps = 32/494 (6%)
Query: 57 LKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQ---IMDDCYYQGHILN 113
L ++ K ++ L++N+ L+A +TET+Y G +++ + I+ CYY GH+
Sbjct: 68 LNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRG 127
Query: 114 EKVSDASISTCRGLRGYFSQGDQRYFIEPL-SPIHRDGQEHALFKYNPDEK--NYDSTCG 170
S S+STC GLRG ++ Y +EP+ S +R +K P +K + +CG
Sbjct: 128 YSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR-------YKLFPAKKLKSVRGSCG 180
Query: 171 MDGVLWAHDLQQNIAL------PATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQ 224
+H N+A P+ + R+ + KY+E +V DN EF+R ++
Sbjct: 181 ------SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234
Query: 225 DEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVL 284
+++++R+ E+AN+V+ Y+ LN + LVG+E+W D DK ++ + +L F WR L
Sbjct: 235 EKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKL 294
Query: 285 SRRKRHDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGH 343
RK HD AQL++ GTT+G+A + +MC+ S G+V DHSDN L A T+AHE+GH
Sbjct: 295 LPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGH 354
Query: 344 NFGMFHD--DYSCKCPSTI----CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFN 397
NFGM HD D C C + C+M+ + + P FSSCSR + E + CLFN
Sbjct: 355 NFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFN 414
Query: 398 APLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQ 457
P + CGN+ VE GE+CDCG EEC N CC+A TC +K CA G CCE CQ
Sbjct: 415 LPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQ 474
Query: 458 FKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCT 517
K AG CR + + CDLPE C G S +CP + + +G C G+C G C T ++QC
Sbjct: 475 LKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCV 534
Query: 518 ELWGPGRRTNPFPC 531
LWGPG + P C
Sbjct: 535 TLWGPGAKPAPGIC 548
>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
preproprotein [Homo sapiens]
Length = 813
Score = 341 bits (874), Expect = 1e-93
Identities = 187/480 (38%), Positives = 266/480 (55%), Gaps = 23/480 (4%)
Query: 65 GKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTC 124
G+ +L L+KN LLAPGY ET+Y G+ + +P D C+YQG + S + TC
Sbjct: 74 GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133
Query: 125 RGLRGYFSQG-DQRYFIEPLSPI-HRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDLQQ 182
G+ G + + Y++ P P +D H +F+ + TCG H
Sbjct: 134 SGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRME-QLLTWKGTCG-------HRDPG 185
Query: 183 NIA----LPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYV 238
N A LP + + R+ + KY+E Y+V D+ F + N + ++R+ E+ANYV
Sbjct: 186 NKAGMTSLPGGPQSRGR-REARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244
Query: 239 NMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITA 298
+ L + L+ VAL G+E+WT++D+ ++T +A+ TL F +WR + ++R HD AQL+T
Sbjct: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRP-HDSAQLLTG 303
Query: 299 TELAGTTVGLAFMSTMC-SPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSC--- 354
G TVGLA + MC + S GV DHS+ + A TMAHE+GH+ G+ HD C
Sbjct: 304 RAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVE 363
Query: 355 -KCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQ 413
S CVM A P FS+CSR FF CL NAP P + +CGN
Sbjct: 364 AAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNG 423
Query: 414 LVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECD 473
VE GE+CDCG +EC ++CC A C ++ QCA G+CC +C K AG +CR A +CD
Sbjct: 424 FVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCD 483
Query: 474 LPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGRRTNPFPCAC 533
LPE C G S +CP D + ++G PC G G+C G CPTL++QC +LWGPG ++P P AC
Sbjct: 484 LPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPG--SHPAPEAC 541
>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
preproprotein [Homo sapiens]
Length = 787
Score = 341 bits (874), Expect = 1e-93
Identities = 187/480 (38%), Positives = 266/480 (55%), Gaps = 23/480 (4%)
Query: 65 GKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTC 124
G+ +L L+KN LLAPGY ET+Y G+ + +P D C+YQG + S + TC
Sbjct: 74 GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133
Query: 125 RGLRGYFSQG-DQRYFIEPLSPI-HRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDLQQ 182
G+ G + + Y++ P P +D H +F+ + TCG H
Sbjct: 134 SGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRME-QLLTWKGTCG-------HRDPG 185
Query: 183 NIA----LPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYV 238
N A LP + + R+ + KY+E Y+V D+ F + N + ++R+ E+ANYV
Sbjct: 186 NKAGMTSLPGGPQSRGR-REARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244
Query: 239 NMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITA 298
+ L + L+ VAL G+E+WT++D+ ++T +A+ TL F +WR + ++R HD AQL+T
Sbjct: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRP-HDSAQLLTG 303
Query: 299 TELAGTTVGLAFMSTMC-SPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSC--- 354
G TVGLA + MC + S GV DHS+ + A TMAHE+GH+ G+ HD C
Sbjct: 304 RAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVE 363
Query: 355 -KCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQ 413
S CVM A P FS+CSR FF CL NAP P + +CGN
Sbjct: 364 AAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNG 423
Query: 414 LVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECD 473
VE GE+CDCG +EC ++CC A C ++ QCA G+CC +C K AG +CR A +CD
Sbjct: 424 FVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCD 483
Query: 474 LPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGRRTNPFPCAC 533
LPE C G S +CP D + ++G PC G G+C G CPTL++QC +LWGPG ++P P AC
Sbjct: 484 LPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPG--SHPAPEAC 541
>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
sapiens]
Length = 819
Score = 333 bits (855), Expect = 2e-91
Identities = 187/540 (34%), Positives = 281/540 (52%), Gaps = 27/540 (5%)
Query: 1 MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYK 60
+L GL V +L A ++ + YE++ P RL +REA P + ++ Y
Sbjct: 18 LLLGL--VGPVLGAARPGFQQTSHLSSYEIITPWRL-TRERREAPRP-----YSKQVSYV 69
Query: 61 MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS 120
+ GK +++L++NK+LL + YN G IT P I + C+Y+G++ S +
Sbjct: 70 IQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIA 129
Query: 121 ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDL 180
+S C GLRG + Y IEPL + EH +++ + D CG+ D+
Sbjct: 130 LSDCFGLRGLLHLENASYGIEPLQ--NSSHFEHIIYRMD-DVYKEPLKCGVSN----KDI 182
Query: 181 QQNIAL------PATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEM 234
++ A P+ + + R V +Y+E ++V+D + NQ +R+ + +
Sbjct: 183 EKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILL 242
Query: 235 ANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQ 294
ANY++ +Y LN + LVG+EIWT+ + I I A L NF +WR L R+RHD AQ
Sbjct: 243 ANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQ 302
Query: 295 LITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRV-AGTMAHEMGHNFGMFHDD-Y 352
L+ GT G+AF+ T+CS G + + A +AHE+GHN GM HDD
Sbjct: 303 LVLKKGFGGTA-GMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGR 361
Query: 353 SCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGN 412
C C + C+M+ S +FSSCS ++K +K NCL N P P + S P CGN
Sbjct: 362 DCSCGAKSCIMNSGASG--SRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGN 419
Query: 413 QLVEMGEDCDCGTSEECT-NICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDE 471
+LV+ GE+CDCGT +EC + CC+ TCK+K+ +CA G+CC+ C+F G +CR E
Sbjct: 420 KLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSE 479
Query: 472 CDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGRRTNPFPC 531
CD+PE CNG S C D F NG+PC + K +C G C QC ++G + P C
Sbjct: 480 CDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDC 539
>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
preproprotein [Homo sapiens]
Length = 863
Score = 313 bits (802), Expect = 3e-85
Identities = 174/482 (36%), Positives = 257/482 (53%), Gaps = 13/482 (2%)
Query: 50 QEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQG 109
Q L+ K+ ++G +L L +N+ L+ T +Y G + + +++C YQG
Sbjct: 62 QTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQG 121
Query: 110 HILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTC 169
+ S SI TC GLRG +R + P D Q + D TC
Sbjct: 122 RVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGP--GDLQGPPIISRIQDLHLPGHTC 179
Query: 170 GMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRK 229
+ H Q+ P + + R V K +E +V D+ E ++Y + Q +
Sbjct: 180 ALSWRESVHT-QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-HLLN 237
Query: 230 RVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKR 289
R E+A ++ ++ LN VALVG+E WT +D ++I+PN + TLENF WR + L R
Sbjct: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
Query: 290 HDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGHNFGMF 348
HD AQL+T T +G TVG+A +++CSP +S GV DHS ++L VA ++AHE+GH+ G+
Sbjct: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357
Query: 349 HD--DYSCKC----PSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPT 402
HD SC C P+ C+M+ + F +FS+CSR + +K D + +CLF LP+
Sbjct: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPS 416
Query: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCAL-GECCEKCQFKKA 461
CGN VE GE CDCG ++C + CCD+ TC+++ QCA G CC+ CQ + +
Sbjct: 417 LPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPS 476
Query: 462 GMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWG 521
G CRP + +CDLPE C G S CP D +G PC G+ C+ G C + +QC LWG
Sbjct: 477 GWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWG 536
Query: 522 PG 523
PG
Sbjct: 537 PG 538
>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
preproprotein [Homo sapiens]
Length = 862
Score = 313 bits (802), Expect = 3e-85
Identities = 174/482 (36%), Positives = 257/482 (53%), Gaps = 13/482 (2%)
Query: 50 QEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQG 109
Q L+ K+ ++G +L L +N+ L+ T +Y G + + +++C YQG
Sbjct: 62 QTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQG 121
Query: 110 HILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTC 169
+ S SI TC GLRG +R + P D Q + D TC
Sbjct: 122 RVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGP--GDLQGPPIISRIQDLHLPGHTC 179
Query: 170 GMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRK 229
+ H Q+ P + + R V K +E +V D+ E ++Y + Q +
Sbjct: 180 ALSWRESVHT-QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-HLLN 237
Query: 230 RVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKR 289
R E+A ++ ++ LN VALVG+E WT +D ++I+PN + TLENF WR + L R
Sbjct: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
Query: 290 HDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGHNFGMF 348
HD AQL+T T +G TVG+A +++CSP +S GV DHS ++L VA ++AHE+GH+ G+
Sbjct: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357
Query: 349 HD--DYSCKC----PSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPT 402
HD SC C P+ C+M+ + F +FS+CSR + +K D + +CLF LP+
Sbjct: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPS 416
Query: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCAL-GECCEKCQFKKA 461
CGN VE GE CDCG ++C + CCD+ TC+++ QCA G CC+ CQ + +
Sbjct: 417 LPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPS 476
Query: 462 GMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWG 521
G CRP + +CDLPE C G S CP D +G PC G+ C+ G C + +QC LWG
Sbjct: 477 GWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWG 536
Query: 522 PG 523
PG
Sbjct: 537 PG 538
>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
preproprotein [Homo sapiens]
Length = 838
Score = 313 bits (802), Expect = 3e-85
Identities = 174/482 (36%), Positives = 257/482 (53%), Gaps = 13/482 (2%)
Query: 50 QEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQG 109
Q L+ K+ ++G +L L +N+ L+ T +Y G + + +++C YQG
Sbjct: 62 QTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQG 121
Query: 110 HILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTC 169
+ S SI TC GLRG +R + P D Q + D TC
Sbjct: 122 RVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGP--GDLQGPPIISRIQDLHLPGHTC 179
Query: 170 GMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRK 229
+ H Q+ P + + R V K +E +V D+ E ++Y + Q +
Sbjct: 180 ALSWRESVHT-QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-HLLN 237
Query: 230 RVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKR 289
R E+A ++ ++ LN VALVG+E WT +D ++I+PN + TLENF WR + L R
Sbjct: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
Query: 290 HDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGHNFGMF 348
HD AQL+T T +G TVG+A +++CSP +S GV DHS ++L VA ++AHE+GH+ G+
Sbjct: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357
Query: 349 HD--DYSCKC----PSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPT 402
HD SC C P+ C+M+ + F +FS+CSR + +K D + +CLF LP+
Sbjct: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPS 416
Query: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCAL-GECCEKCQFKKA 461
CGN VE GE CDCG ++C + CCD+ TC+++ QCA G CC+ CQ + +
Sbjct: 417 LPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPS 476
Query: 462 GMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWG 521
G CRP + +CDLPE C G S CP D +G PC G+ C+ G C + +QC LWG
Sbjct: 477 GWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWG 536
Query: 522 PG 523
PG
Sbjct: 537 PG 538
>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
preproprotein [Homo sapiens]
Length = 839
Score = 313 bits (802), Expect = 3e-85
Identities = 174/482 (36%), Positives = 257/482 (53%), Gaps = 13/482 (2%)
Query: 50 QEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQG 109
Q L+ K+ ++G +L L +N+ L+ T +Y G + + +++C YQG
Sbjct: 62 QTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQG 121
Query: 110 HILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTC 169
+ S SI TC GLRG +R + P D Q + D TC
Sbjct: 122 RVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGP--GDLQGPPIISRIQDLHLPGHTC 179
Query: 170 GMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRK 229
+ H Q+ P + + R V K +E +V D+ E ++Y + Q +
Sbjct: 180 ALSWRESVHT-QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-HLLN 237
Query: 230 RVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKR 289
R E+A ++ ++ LN VALVG+E WT +D ++I+PN + TLENF WR + L R
Sbjct: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
Query: 290 HDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGHNFGMF 348
HD AQL+T T +G TVG+A +++CSP +S GV DHS ++L VA ++AHE+GH+ G+
Sbjct: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357
Query: 349 HD--DYSCKC----PSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPT 402
HD SC C P+ C+M+ + F +FS+CSR + +K D + +CLF LP+
Sbjct: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPS 416
Query: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCAL-GECCEKCQFKKA 461
CGN VE GE CDCG ++C + CCD+ TC+++ QCA G CC+ CQ + +
Sbjct: 417 LPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPS 476
Query: 462 GMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWG 521
G CRP + +CDLPE C G S CP D +G PC G+ C+ G C + +QC LWG
Sbjct: 477 GWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWG 536
Query: 522 PG 523
PG
Sbjct: 537 PG 538
>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
preproprotein [Homo sapiens]
Length = 772
Score = 313 bits (802), Expect = 3e-85
Identities = 174/482 (36%), Positives = 257/482 (53%), Gaps = 13/482 (2%)
Query: 50 QEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQG 109
Q L+ K+ ++G +L L +N+ L+ T +Y G + + +++C YQG
Sbjct: 62 QTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQG 121
Query: 110 HILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTC 169
+ S SI TC GLRG +R + P D Q + D TC
Sbjct: 122 RVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGP--GDLQGPPIISRIQDLHLPGHTC 179
Query: 170 GMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRK 229
+ H Q+ P + + R V K +E +V D+ E ++Y + Q +
Sbjct: 180 ALSWRESVHT-QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-HLLN 237
Query: 230 RVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKR 289
R E+A ++ ++ LN VALVG+E WT +D ++I+PN + TLENF WR + L R
Sbjct: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
Query: 290 HDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGHNFGMF 348
HD AQL+T T +G TVG+A +++CSP +S GV DHS ++L VA ++AHE+GH+ G+
Sbjct: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357
Query: 349 HD--DYSCKC----PSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPT 402
HD SC C P+ C+M+ + F +FS+CSR + +K D + +CLF LP+
Sbjct: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPS 416
Query: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCAL-GECCEKCQFKKA 461
CGN VE GE CDCG ++C + CCD+ TC+++ QCA G CC+ CQ + +
Sbjct: 417 LPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPS 476
Query: 462 GMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWG 521
G CRP + +CDLPE C G S CP D +G PC G+ C+ G C + +QC LWG
Sbjct: 477 GWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWG 536
Query: 522 PG 523
PG
Sbjct: 537 PG 538
>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
preproprotein [Homo sapiens]
Length = 814
Score = 313 bits (802), Expect = 3e-85
Identities = 174/482 (36%), Positives = 257/482 (53%), Gaps = 13/482 (2%)
Query: 50 QEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQG 109
Q L+ K+ ++G +L L +N+ L+ T +Y G + + +++C YQG
Sbjct: 62 QTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQG 121
Query: 110 HILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTC 169
+ S SI TC GLRG +R + P D Q + D TC
Sbjct: 122 RVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGP--GDLQGPPIISRIQDLHLPGHTC 179
Query: 170 GMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRK 229
+ H Q+ P + + R V K +E +V D+ E ++Y + Q +
Sbjct: 180 ALSWRESVHT-QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-HLLN 237
Query: 230 RVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKR 289
R E+A ++ ++ LN VALVG+E WT +D ++I+PN + TLENF WR + L R
Sbjct: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
Query: 290 HDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGHNFGMF 348
HD AQL+T T +G TVG+A +++CSP +S GV DHS ++L VA ++AHE+GH+ G+
Sbjct: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357
Query: 349 HD--DYSCKC----PSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPT 402
HD SC C P+ C+M+ + F +FS+CSR + +K D + +CLF LP+
Sbjct: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPS 416
Query: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCAL-GECCEKCQFKKA 461
CGN VE GE CDCG ++C + CCD+ TC+++ QCA G CC+ CQ + +
Sbjct: 417 LPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPS 476
Query: 462 GMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWG 521
G CRP + +CDLPE C G S CP D +G PC G+ C+ G C + +QC LWG
Sbjct: 477 GWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWG 536
Query: 522 PG 523
PG
Sbjct: 537 PG 538
>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
sapiens]
Length = 776
Score = 254 bits (649), Expect = 1e-67
Identities = 159/511 (31%), Positives = 246/511 (48%), Gaps = 29/511 (5%)
Query: 29 EVVYPIRLHPLHKREAKEPEQQEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYY 88
EVV P+++ R AK P L Y + G+ +++++ NK L A Y
Sbjct: 91 EVVIPLKVIS-RGRGAKAPGW-------LSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTY 142
Query: 89 NSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTCRG-LRGYFSQGDQRYFIEPLSPIH 147
+ P I DDCYY G++ S ++STC G G D Y I+P+S
Sbjct: 143 TEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTCSGGFLGMLQINDLVYEIKPISVSA 202
Query: 148 RDGQEHALFKYNPDEKNYDST-CGMDGVLWAHDLQQNIALPATKLVKLKDRKVQ---EHE 203
EH ++K + D+ + CG+ AH ++ ++ T LK H+
Sbjct: 203 TF--EHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLSYNFT----LKQSSFVGWWTHQ 256
Query: 204 KYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKI 263
+++E +V+DN + N ++ VF + N V+ Y L V L G++IWT + +
Sbjct: 257 RFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPLEVDVILTGIDIWTASNPL 316
Query: 264 KITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATELAGTTVGLAFMSTMC-SPYSVGV 322
+ + LE+FS W+ L+ R +HD+A L + G +G+A++ +C +P++ GV
Sbjct: 317 PTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIK-DTQGMKLGVAYVKGICQNPFNTGV 375
Query: 323 VQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRLS 382
+ L+ A T+ HE+GHN GM HD C C C+M + T FS+CS
Sbjct: 376 DVFEDNRLVVFAITLGHELGHNLGMQHDTQWCVCELQWCIMHAYRK--VTTKFSNCS--- 430
Query: 383 YDKFFEDKLSN--CLFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCK 440
Y ++++ +S+ C+ P P +I CGN +VE GE+CDCGT +C C C
Sbjct: 431 YAQYWDSTISSGLCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPCCLLNCT 490
Query: 441 IKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHG 500
+ CA G CC+ C+F +G +CR ECDLPE CNG S CPDD + +G C +
Sbjct: 491 LHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISC-NV 549
Query: 501 KGHCLMGTCPTLQEQCTELWGPGRRTNPFPC 531
C TC QC E++G R+ C
Sbjct: 550 NAFCYEKTCNNHDIQCKEIFGQDARSASQSC 580
>gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo
sapiens]
Length = 735
Score = 251 bits (642), Expect = 9e-67
Identities = 157/490 (32%), Positives = 243/490 (49%), Gaps = 24/490 (4%)
Query: 50 QEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQG 109
+E E++ YK+ I GK + L + KN L + Y+ TG + C+YQG
Sbjct: 38 KEGIESQASYKIVIEGKPYTVNLMQ-KNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQG 96
Query: 110 HILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTC 169
+I S +STC GLRG + Y IEPL G EH + Y K D +
Sbjct: 97 YIEGYPKSVVMVSTCTGLRGVLQFENVSYGIEPLES--SVGFEHVI--YQVKHKKADVSL 152
Query: 170 GMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRK 229
+ + + DL + KL ++ + Q+ KYIE +++++ + + + +
Sbjct: 153 YNEKDIESRDL-------SFKLQSVEPQ--QDFAKYIEMHVIVEKQLYNHMGSDTTVVAQ 203
Query: 230 RVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKR 289
+VF++ N ++ N + L +E+W D++KI T A+ L F +W+ S L R
Sbjct: 204 KVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLRP- 262
Query: 290 HDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVV-QDHSDNLLRVAGTMAHEMGHNFGM 347
HD+A L+ E + VG F MC Y+ GVV + +L +A +A + + G+
Sbjct: 263 HDVAFLLVYREKSNY-VGATFQGKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGI 321
Query: 348 FHDDYS-CKCPSTICVMD-KALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAP-LPTDI 404
+DD + C+C +C+M+ +A+ F FS+CS + F + S CL N P L
Sbjct: 322 TYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFF 381
Query: 405 ISTPICGNQLVEMGEDCDCGTSEECTNI---CCDAKTCKIKATFQCALGECCEKCQFKKA 461
+CGN +E GE+CDCGT ++C I CCD TC+ KA CA G CCE C F
Sbjct: 382 KQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSK 441
Query: 462 GMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWG 521
+CRP+ +ECDLPE CNG S +CP++ + G PC + C+ G C + +QCT+ +G
Sbjct: 442 ERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFG 501
Query: 522 PGRRTNPFPC 531
P C
Sbjct: 502 KEVEFGPSEC 511
>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 242 bits (618), Expect = 5e-64
Identities = 146/489 (29%), Positives = 236/489 (48%), Gaps = 34/489 (6%)
Query: 57 LKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKV 116
L Y + G+ ++++K K L + Y G + P + ++CYY G++ +
Sbjct: 52 LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPE 111
Query: 117 SDASISTC-RGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDS-------- 167
S S+STC G +G D Y I+PL+ EH ++K + +EK + +
Sbjct: 112 SLVSLSTCFGGFQGILQINDFAYEIKPLA--FSTTFEHLVYKMDSEEKQFSTMRSGFMQN 169
Query: 168 --TCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQD 225
TC M+ + Q+ + + H + +E +V+DN + RY N
Sbjct: 170 EITCRMEFEEIDNSTQKQSSYVGWWI----------HFRIVEIVVVIDNYLYIRYERNDS 219
Query: 226 EIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLS 285
++ + ++ + N V+ + + V L G+EIWT+K+ I + + ++ + KW+ ++
Sbjct: 220 KLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENIT 278
Query: 286 RRKRHDIAQLITATELAGTTVGLAFMSTMCSPY-SVGVVQDHSDNLLRVAGTMAHEMGHN 344
R +HD + L T L G + G+ MC+P+ S +V + L + +AH +GHN
Sbjct: 279 PRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHN 337
Query: 345 FGMFHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKL--SNCLFNAPLPT 402
GM HD+ +C+C C+M + T FS+CS Y F+E + + CL
Sbjct: 338 LGMNHDEDTCRCSQPRCIMHEGNPPI--TKFSNCS---YGDFWEYTVERTKCLLETVHTK 392
Query: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAG 462
DI + CGN +VE GE+CDCG + C C C + CA G CC+ C+F +G
Sbjct: 393 DIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSG 452
Query: 463 MVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGP 522
VCR +ECDLPE CNG S CPDD + +G PC +G+C +C EQC ++G
Sbjct: 453 KVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCKE-RGYCYEKSCHDRNEQCRRIFGA 511
Query: 523 GRRTNPFPC 531
G T C
Sbjct: 512 GANTASETC 520
>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 242 bits (618), Expect = 5e-64
Identities = 146/489 (29%), Positives = 236/489 (48%), Gaps = 34/489 (6%)
Query: 57 LKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKV 116
L Y + G+ ++++K K L + Y G + P + ++CYY G++ +
Sbjct: 52 LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPE 111
Query: 117 SDASISTC-RGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDS-------- 167
S S+STC G +G D Y I+PL+ EH ++K + +EK + +
Sbjct: 112 SLVSLSTCFGGFQGILQINDFAYEIKPLA--FSTTFEHLVYKMDSEEKQFSTMRSGFMQN 169
Query: 168 --TCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQD 225
TC M+ + Q+ + + H + +E +V+DN + RY N
Sbjct: 170 EITCRMEFEEIDNSTQKQSSYVGWWI----------HFRIVEIVVVIDNYLYIRYERNDS 219
Query: 226 EIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLS 285
++ + ++ + N V+ + + V L G+EIWT+K+ I + + ++ + KW+ ++
Sbjct: 220 KLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENIT 278
Query: 286 RRKRHDIAQLITATELAGTTVGLAFMSTMCSPY-SVGVVQDHSDNLLRVAGTMAHEMGHN 344
R +HD + L T L G + G+ MC+P+ S +V + L + +AH +GHN
Sbjct: 279 PRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHN 337
Query: 345 FGMFHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKL--SNCLFNAPLPT 402
GM HD+ +C+C C+M + T FS+CS Y F+E + + CL
Sbjct: 338 LGMNHDEDTCRCSQPRCIMHEGNPPI--TKFSNCS---YGDFWEYTVERTKCLLETVHTK 392
Query: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAG 462
DI + CGN +VE GE+CDCG + C C C + CA G CC+ C+F +G
Sbjct: 393 DIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSG 452
Query: 463 MVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGP 522
VCR +ECDLPE CNG S CPDD + +G PC +G+C +C EQC ++G
Sbjct: 453 KVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCKE-RGYCYEKSCHDRNEQCRRIFGA 511
Query: 523 GRRTNPFPC 531
G T C
Sbjct: 512 GANTASETC 520
>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 242 bits (618), Expect = 5e-64
Identities = 146/489 (29%), Positives = 236/489 (48%), Gaps = 34/489 (6%)
Query: 57 LKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKV 116
L Y + G+ ++++K K L + Y G + P + ++CYY G++ +
Sbjct: 52 LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPE 111
Query: 117 SDASISTC-RGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDS-------- 167
S S+STC G +G D Y I+PL+ EH ++K + +EK + +
Sbjct: 112 SLVSLSTCFGGFQGILQINDFAYEIKPLA--FSTTFEHLVYKMDSEEKQFSTMRSGFMQN 169
Query: 168 --TCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQD 225
TC M+ + Q+ + + H + +E +V+DN + RY N
Sbjct: 170 EITCRMEFEEIDNSTQKQSSYVGWWI----------HFRIVEIVVVIDNYLYIRYERNDS 219
Query: 226 EIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLS 285
++ + ++ + N V+ + + V L G+EIWT+K+ I + + ++ + KW+ ++
Sbjct: 220 KLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENIT 278
Query: 286 RRKRHDIAQLITATELAGTTVGLAFMSTMCSPY-SVGVVQDHSDNLLRVAGTMAHEMGHN 344
R +HD + L T L G + G+ MC+P+ S +V + L + +AH +GHN
Sbjct: 279 PRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHN 337
Query: 345 FGMFHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKL--SNCLFNAPLPT 402
GM HD+ +C+C C+M + T FS+CS Y F+E + + CL
Sbjct: 338 LGMNHDEDTCRCSQPRCIMHEGNPPI--TKFSNCS---YGDFWEYTVERTKCLLETVHTK 392
Query: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAG 462
DI + CGN +VE GE+CDCG + C C C + CA G CC+ C+F +G
Sbjct: 393 DIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSG 452
Query: 463 MVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGP 522
VCR +ECDLPE CNG S CPDD + +G PC +G+C +C EQC ++G
Sbjct: 453 KVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCKE-RGYCYEKSCHDRNEQCRRIFGA 511
Query: 523 GRRTNPFPC 531
G T C
Sbjct: 512 GANTASETC 520
>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 242 bits (618), Expect = 5e-64
Identities = 146/489 (29%), Positives = 236/489 (48%), Gaps = 34/489 (6%)
Query: 57 LKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKV 116
L Y + G+ ++++K K L + Y G + P + ++CYY G++ +
Sbjct: 52 LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPE 111
Query: 117 SDASISTC-RGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDS-------- 167
S S+STC G +G D Y I+PL+ EH ++K + +EK + +
Sbjct: 112 SLVSLSTCFGGFQGILQINDFAYEIKPLA--FSTTFEHLVYKMDSEEKQFSTMRSGFMQN 169
Query: 168 --TCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQD 225
TC M+ + Q+ + + H + +E +V+DN + RY N
Sbjct: 170 EITCRMEFEEIDNSTQKQSSYVGWWI----------HFRIVEIVVVIDNYLYIRYERNDS 219
Query: 226 EIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLS 285
++ + ++ + N V+ + + V L G+EIWT+K+ I + + ++ + KW+ ++
Sbjct: 220 KLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENIT 278
Query: 286 RRKRHDIAQLITATELAGTTVGLAFMSTMCSPY-SVGVVQDHSDNLLRVAGTMAHEMGHN 344
R +HD + L T L G + G+ MC+P+ S +V + L + +AH +GHN
Sbjct: 279 PRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHN 337
Query: 345 FGMFHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKL--SNCLFNAPLPT 402
GM HD+ +C+C C+M + T FS+CS Y F+E + + CL
Sbjct: 338 LGMNHDEDTCRCSQPRCIMHEGNPPI--TKFSNCS---YGDFWEYTVERTKCLLETVHTK 392
Query: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAG 462
DI + CGN +VE GE+CDCG + C C C + CA G CC+ C+F +G
Sbjct: 393 DIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSG 452
Query: 463 MVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGP 522
VCR +ECDLPE CNG S CPDD + +G PC +G+C +C EQC ++G
Sbjct: 453 KVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCKE-RGYCYEKSCHDRNEQCRRIFGA 511
Query: 523 GRRTNPFPC 531
G T C
Sbjct: 512 GANTASETC 520
>gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo
sapiens]
Length = 769
Score = 239 bits (610), Expect = 5e-63
Identities = 152/474 (32%), Positives = 230/474 (48%), Gaps = 35/474 (7%)
Query: 70 LYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTCRGLRG 129
L L+ N +LL+ Y E +++ G S D CYYQG + S A++STC+GL G
Sbjct: 99 LDLELNHHLLSSQYVERHFSREGTT-QHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHG 157
Query: 130 YFSQGDQRYFIEPLSPIHRDGQE-----HALFKYN--PDEKNYDSTCGMDGVLWAHDLQQ 182
FS G+ Y +EP G H +++ PD C G L+A Q
Sbjct: 158 VFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLG----CREPGCLFAVPAQS 213
Query: 183 ----NIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYV 238
L + V+ V KY+E ++ D+ F++ ++ + N
Sbjct: 214 APPNRPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLA 273
Query: 239 NMLYKK-LNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLIT 297
+++YK+ LNT + LV ME W D DKI++ + TL +R L D L +
Sbjct: 274 DVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRREGLPEPS--DATHLFS 331
Query: 298 ATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDY----- 352
T+ G A++ +CS G V ++ N+ +A T+A +G N GM + +
Sbjct: 332 GRTFQSTSSGAAYVGGICSLSHGGGVNEYG-NMGAMAVTLAQTLGQNLGMMWNKHRSSAG 390
Query: 353 SCKCPSTI--CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPIC 410
CKCP C+M+ FY+P FS CS Y++F ++ +CLFN PL ++ P C
Sbjct: 391 DCKCPDIWLGCIMEDT-GFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLK--LLDPPEC 447
Query: 411 GNQLVEMGEDCDCGTSEECTNI---CCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRP 467
GN VE GE+CDCG+ +EC+ CC K C + C+ G CC +C+++ G+ CR
Sbjct: 448 GNGFVEAGEECDCGSVQECSRAGGNCC--KKCTLTHDAMCSDGLCCRRCKYEPRGVSCRE 505
Query: 468 AKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWG 521
A +ECD+ E C G S CP + +++G+ C H +G C G C T QC LWG
Sbjct: 506 AVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQVLWG 559
>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
[Homo sapiens]
Length = 906
Score = 237 bits (605), Expect = 2e-62
Identities = 149/490 (30%), Positives = 229/490 (46%), Gaps = 42/490 (8%)
Query: 56 ELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEK 115
+ +++ G +L + N +LL+ Y E + GK + + CYYQGHI
Sbjct: 88 QASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNP 145
Query: 116 VSDASISTCRGLRGYFSQGDQRYFIEPLS--PIHRDGQEHALFKYNPDEKNYDSTCGMDG 173
S ++STC GL G F G+ Y IEP D H+++K E + D
Sbjct: 146 DSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDL----- 200
Query: 174 VLWAHDLQQNIALPATKLVKLKD-----------RKVQEHEKYIEYYLVLDNGEFKRYNE 222
+ QQ P+ ++K + R V+E KYIE +V D+ FK++
Sbjct: 201 ---PSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRL 257
Query: 223 NQDEIRKRVFEMANYVNMLYK-KLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRG 281
+ + N +++YK +L T + LV ME W +K I+ N TL F K+R
Sbjct: 258 SVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRR 317
Query: 282 SVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEM 341
+ +++ D L + ++ + G A++ +CS G V + L +A T+A +
Sbjct: 318 DFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDL-MAVTLAQSL 374
Query: 342 GHNFGMFHDDYS-----CKCPSTI--CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNC 394
HN G+ D CKC T C+M +Y+P F+ C+ Y F C
Sbjct: 375 AHNIGIISDKRKLASGECKCEDTWSGCIMGDT-GYYLPKKFTQCNIEEYHDFLNSGGGAC 433
Query: 395 LFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECT---NICCDAKTCKIKATFQCALGE 451
LFN P + ++ P CGN +E GE+CDCGT EC CC K C + QC+ G
Sbjct: 434 LFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDSQCSDGL 489
Query: 452 CCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPT 511
CC+KC+F+ G VCR A ++CD+ E C+G S C + +++G+ C +G C G C T
Sbjct: 490 CCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKT 549
Query: 512 LQEQCTELWG 521
QC +WG
Sbjct: 550 RDRQCKYIWG 559
>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
[Homo sapiens]
Length = 899
Score = 237 bits (605), Expect = 2e-62
Identities = 149/490 (30%), Positives = 229/490 (46%), Gaps = 42/490 (8%)
Query: 56 ELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEK 115
+ +++ G +L + N +LL+ Y E + GK + + CYYQGHI
Sbjct: 88 QASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNP 145
Query: 116 VSDASISTCRGLRGYFSQGDQRYFIEPLS--PIHRDGQEHALFKYNPDEKNYDSTCGMDG 173
S ++STC GL G F G+ Y IEP D H+++K E + D
Sbjct: 146 DSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDL----- 200
Query: 174 VLWAHDLQQNIALPATKLVKLKD-----------RKVQEHEKYIEYYLVLDNGEFKRYNE 222
+ QQ P+ ++K + R V+E KYIE +V D+ FK++
Sbjct: 201 ---PSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRL 257
Query: 223 NQDEIRKRVFEMANYVNMLYK-KLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRG 281
+ + N +++YK +L T + LV ME W +K I+ N TL F K+R
Sbjct: 258 SVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRR 317
Query: 282 SVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEM 341
+ +++ D L + ++ + G A++ +CS G V + L +A T+A +
Sbjct: 318 DFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDL-MAVTLAQSL 374
Query: 342 GHNFGMFHDDYS-----CKCPSTI--CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNC 394
HN G+ D CKC T C+M +Y+P F+ C+ Y F C
Sbjct: 375 AHNIGIISDKRKLASGECKCEDTWSGCIMGDT-GYYLPKKFTQCNIEEYHDFLNSGGGAC 433
Query: 395 LFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECT---NICCDAKTCKIKATFQCALGE 451
LFN P + ++ P CGN +E GE+CDCGT EC CC K C + QC+ G
Sbjct: 434 LFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDSQCSDGL 489
Query: 452 CCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPT 511
CC+KC+F+ G VCR A ++CD+ E C+G S C + +++G+ C +G C G C T
Sbjct: 490 CCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKT 549
Query: 512 LQEQCTELWG 521
QC +WG
Sbjct: 550 RDRQCKYIWG 559
>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
[Homo sapiens]
Length = 823
Score = 237 bits (605), Expect = 2e-62
Identities = 149/490 (30%), Positives = 229/490 (46%), Gaps = 42/490 (8%)
Query: 56 ELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEK 115
+ +++ G +L + N +LL+ Y E + GK + + CYYQGHI
Sbjct: 88 QASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNP 145
Query: 116 VSDASISTCRGLRGYFSQGDQRYFIEPLS--PIHRDGQEHALFKYNPDEKNYDSTCGMDG 173
S ++STC GL G F G+ Y IEP D H+++K E + D
Sbjct: 146 DSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDL----- 200
Query: 174 VLWAHDLQQNIALPATKLVKLKD-----------RKVQEHEKYIEYYLVLDNGEFKRYNE 222
+ QQ P+ ++K + R V+E KYIE +V D+ FK++
Sbjct: 201 ---PSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRL 257
Query: 223 NQDEIRKRVFEMANYVNMLYK-KLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRG 281
+ + N +++YK +L T + LV ME W +K I+ N TL F K+R
Sbjct: 258 SVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRR 317
Query: 282 SVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEM 341
+ +++ D L + ++ + G A++ +CS G V + L +A T+A +
Sbjct: 318 DFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDL-MAVTLAQSL 374
Query: 342 GHNFGMFHDDYS-----CKCPSTI--CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNC 394
HN G+ D CKC T C+M +Y+P F+ C+ Y F C
Sbjct: 375 AHNIGIISDKRKLASGECKCEDTWSGCIMGDT-GYYLPKKFTQCNIEEYHDFLNSGGGAC 433
Query: 395 LFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECT---NICCDAKTCKIKATFQCALGE 451
LFN P + ++ P CGN +E GE+CDCGT EC CC K C + QC+ G
Sbjct: 434 LFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDSQCSDGL 489
Query: 452 CCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPT 511
CC+KC+F+ G VCR A ++CD+ E C+G S C + +++G+ C +G C G C T
Sbjct: 490 CCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKT 549
Query: 512 LQEQCTELWG 521
QC +WG
Sbjct: 550 RDRQCKYIWG 559
>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
[Homo sapiens]
Length = 870
Score = 237 bits (605), Expect = 2e-62
Identities = 149/490 (30%), Positives = 229/490 (46%), Gaps = 42/490 (8%)
Query: 56 ELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEK 115
+ +++ G +L + N +LL+ Y E + GK + + CYYQGHI
Sbjct: 88 QASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNP 145
Query: 116 VSDASISTCRGLRGYFSQGDQRYFIEPLS--PIHRDGQEHALFKYNPDEKNYDSTCGMDG 173
S ++STC GL G F G+ Y IEP D H+++K E + D
Sbjct: 146 DSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDL----- 200
Query: 174 VLWAHDLQQNIALPATKLVKLKD-----------RKVQEHEKYIEYYLVLDNGEFKRYNE 222
+ QQ P+ ++K + R V+E KYIE +V D+ FK++
Sbjct: 201 ---PSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRL 257
Query: 223 NQDEIRKRVFEMANYVNMLYK-KLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRG 281
+ + N +++YK +L T + LV ME W +K I+ N TL F K+R
Sbjct: 258 SVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRR 317
Query: 282 SVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEM 341
+ +++ D L + ++ + G A++ +CS G V + L +A T+A +
Sbjct: 318 DFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDL-MAVTLAQSL 374
Query: 342 GHNFGMFHDDYS-----CKCPSTI--CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNC 394
HN G+ D CKC T C+M +Y+P F+ C+ Y F C
Sbjct: 375 AHNIGIISDKRKLASGECKCEDTWSGCIMGDT-GYYLPKKFTQCNIEEYHDFLNSGGGAC 433
Query: 395 LFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECT---NICCDAKTCKIKATFQCALGE 451
LFN P + ++ P CGN +E GE+CDCGT EC CC K C + QC+ G
Sbjct: 434 LFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDSQCSDGL 489
Query: 452 CCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPT 511
CC+KC+F+ G VCR A ++CD+ E C+G S C + +++G+ C +G C G C T
Sbjct: 490 CCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKT 549
Query: 512 LQEQCTELWG 521
QC +WG
Sbjct: 550 RDRQCKYIWG 559
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.429
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,274,957
Number of Sequences: 37866
Number of extensions: 1062978
Number of successful extensions: 2900
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 114
Number of HSP's that attempted gapping in prelim test: 2441
Number of HSP's gapped (non-prelim): 367
length of query: 540
length of database: 18,247,518
effective HSP length: 107
effective length of query: 433
effective length of database: 14,195,856
effective search space: 6146805648
effective search space used: 6146805648
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.