Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 5174617
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5174617 nucleotide-binding oligomerization domain containing
1 [Homo sapiens]
(953 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5174617 nucleotide-binding oligomerization domain containing ... 1915 0.0
gi|11545912 nucleotide-binding oligomerization domain containing... 449 e-126
gi|118918429 NOD3 protein [Homo sapiens] 190 5e-48
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 166 1e-40
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 147 6e-35
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 147 6e-35
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 138 2e-32
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 137 5e-32
gi|116268109 nucleotide-binding oligomerization domains 27 [Homo... 132 1e-30
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 130 4e-30
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 127 4e-29
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 122 2e-27
gi|156938336 class II transactivator [Homo sapiens] 119 1e-26
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 113 1e-24
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 112 1e-24
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 112 1e-24
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 112 1e-24
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 112 1e-24
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 112 1e-24
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 112 2e-24
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 112 2e-24
gi|25777608 NLR family member X1 isoform 1 [Homo sapiens] 108 2e-23
gi|25777610 NLR family member X1 isoform 2 [Homo sapiens] 100 6e-21
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens] 99 2e-20
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 94 8e-19
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 90 9e-18
gi|23503285 leucine rich repeat containing 34 [Homo sapiens] 90 1e-17
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 89 3e-17
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 89 3e-17
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 89 3e-17
>gi|5174617 nucleotide-binding oligomerization domain containing 1
[Homo sapiens]
Length = 953
Score = 1915 bits (4961), Expect = 0.0
Identities = 953/953 (100%), Positives = 953/953 (100%)
Query: 1 MEEQGHSEMEIIPSESHPHIQLLKSNRELLVTHIRNTQCLVDNLLKNDYFSAEDAEIVCA 60
MEEQGHSEMEIIPSESHPHIQLLKSNRELLVTHIRNTQCLVDNLLKNDYFSAEDAEIVCA
Sbjct: 1 MEEQGHSEMEIIPSESHPHIQLLKSNRELLVTHIRNTQCLVDNLLKNDYFSAEDAEIVCA 60
Query: 61 CPTQPDKVRKILDLVQSKGEEVSEFFLYLLQQLADAYVDLRPWLLEIGFSPSLLTQSKVV 120
CPTQPDKVRKILDLVQSKGEEVSEFFLYLLQQLADAYVDLRPWLLEIGFSPSLLTQSKVV
Sbjct: 61 CPTQPDKVRKILDLVQSKGEEVSEFFLYLLQQLADAYVDLRPWLLEIGFSPSLLTQSKVV 120
Query: 121 VNTDPVSRYTQQLRHHLGRDSKFVLCYAQKEELLLEEIYMDTIMELVGFSNESLGSLNSL 180
VNTDPVSRYTQQLRHHLGRDSKFVLCYAQKEELLLEEIYMDTIMELVGFSNESLGSLNSL
Sbjct: 121 VNTDPVSRYTQQLRHHLGRDSKFVLCYAQKEELLLEEIYMDTIMELVGFSNESLGSLNSL 180
Query: 181 ACLLDHTTGILNEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFS 240
ACLLDHTTGILNEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFS
Sbjct: 181 ACLLDHTTGILNEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFS 240
Query: 241 CFKESDRLCLQDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPD 300
CFKESDRLCLQDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPD
Sbjct: 241 CFKESDRLCLQDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPD 300
Query: 301 SSCPWEPAHPLVLLANLLSGKLLKGASKLLTARTGIEVPRQFLRKKVLLRGFSPSHLRAY 360
SSCPWEPAHPLVLLANLLSGKLLKGASKLLTARTGIEVPRQFLRKKVLLRGFSPSHLRAY
Sbjct: 301 SSCPWEPAHPLVLLANLLSGKLLKGASKLLTARTGIEVPRQFLRKKVLLRGFSPSHLRAY 360
Query: 361 ARRMFPERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMT 420
ARRMFPERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMT
Sbjct: 361 ARRMFPERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMT 420
Query: 421 LTDVFLLVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQ 480
LTDVFLLVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQ
Sbjct: 421 LTDVFLLVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQ 480
Query: 481 EEVQASGLQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQEL 540
EEVQASGLQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQEL
Sbjct: 481 EEVQASGLQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQEL 540
Query: 541 LRFFQEWMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAK 600
LRFFQEWMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAK
Sbjct: 541 LRFFQEWMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAK 600
Query: 601 QKLLRHLVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLRCIY 660
QKLLRHLVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLRCIY
Sbjct: 601 QKLLRHLVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLRCIY 660
Query: 661 ETQSQKVGQLAARGICANYLKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGV 720
ETQSQKVGQLAARGICANYLKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGV
Sbjct: 661 ETQSQKVGQLAARGICANYLKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGV 720
Query: 721 RELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKIL 780
RELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKIL
Sbjct: 721 RELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKIL 780
Query: 781 DECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHP 840
DECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHP
Sbjct: 781 DECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHP 840
Query: 841 SLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKH 900
SLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKH
Sbjct: 841 SLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKH 900
Query: 901 LWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKVYEDEKRIICF 953
LWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKVYEDEKRIICF
Sbjct: 901 LWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKVYEDEKRIICF 953
>gi|11545912 nucleotide-binding oligomerization domain containing 2
[Homo sapiens]
Length = 1040
Score = 449 bits (1156), Expect = e-126
Identities = 323/944 (34%), Positives = 466/944 (49%), Gaps = 57/944 (6%)
Query: 13 PSESHPHIQLLKSNRELLVTHIRN-TQCLVDNLLKNDYFSAEDA-EIVCACPTQPDKVRK 70
P HP + L+S+R +V + + + ++D + + S + EI T + R+
Sbjct: 125 PHSLHP-ARDLQSHRPAIVRRLHSHVENMLDLAWERGFVSQYECDEIRLPIFTPSQRARR 183
Query: 71 ILDLVQSKGEEVSEFFLYLLQQLADAYVDLRPWLLEIGFSPSLLTQSKVVVNTDPVSRYT 130
+LDL K ++ F L +Q+L + + +Y
Sbjct: 184 LLDLATVKANGLAAFLLQHVQELP--------------------VPLALPLEAATCKKYM 223
Query: 131 QQLRHHLGRDSKFVLCYAQKEELLLEEIYMDTIMEL---VGFSNESLGSLNSLACL-LDH 186
+LR + S+F+ Y E L LE+IY + ++E+ VG + S +L L
Sbjct: 224 AKLRTTVSAQSRFLSTYDGAETLCLEDIYTENVLEVWADVGMAGPPQKSPATLGLEELFS 283
Query: 187 TTGILNEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFSCFKESD 246
T G LN+ +T+ ++G+AG GKS LLQRL LWA G+ F F F CR C +
Sbjct: 284 TPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCRQLQCMAKP- 342
Query: 247 RLCLQDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDL-DLSRVPDSSCPW 305
L ++ LLF+H C+P+ E++F LL P L TFDG DE D R P
Sbjct: 343 -LSVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKFRFTDRER---HCSPT 398
Query: 306 EPAHPLVLLANLLSGKLLKGASKLLTARTGIEVP--RQFLRKKVLLRGFSPSHLRAYARR 363
+P LL NLL G LLK A K++T+R R+++R + L+GFS + Y R+
Sbjct: 399 DPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEFNLKGFSEQGIELYLRK 458
Query: 364 MFPERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTLTD 423
E + DRL+ L+ L LC +P+F W++ +C Q GSP+ T TD
Sbjct: 459 RHHEPGVADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQEGGSPK------TTTD 512
Query: 424 VFLLVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEV 483
++LL+ + L P + + L TL LG++A G+ +VF+ +++
Sbjct: 513 MYLLILQHFLLHATPPDSASQGLGPSL--LRGRLPTLLHLGRLALWGLGMCCYVFSAQQL 570
Query: 484 QASGLQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRF 543
QA+ + D+ LGFL + PG EF H+T Q FF AF+L L V L
Sbjct: 571 QAAQVSPDDISLGFLVRAKGVVPGSTAP-LEFLHITFQCFFAAFYLALSADVPPALLRHL 629
Query: 544 FQEWMPPAGAATTSCYPPFLPFQCLQGSGPARED----LFKNKDH-FQFTNLFLCGLLSK 598
F G S LP C+Q S L K + H Q T FL GLLS+
Sbjct: 630 FN-----CGRPGNSPMARLLPTMCIQASEGKDSSVAALLQKAEPHNLQITAAFLAGLLSR 684
Query: 599 AKQKLLRHLVPA--AALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWML 656
LL + A LRR+ A W L SLR + S+P V AMP FIW++
Sbjct: 685 EHWGLLAECQTSEKALLRRQACARWC-LARSLRKHFHSIPPAAPGEAKSVHAMPGFIWLI 743
Query: 657 RCIYETQSQKVGQLAARGICANYLKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLN 716
R +YE Q +++ + AARG+ +LKLT+C+ +C+AL+FVL H + +AL LD N++
Sbjct: 744 RSLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVG 803
Query: 717 DYGVRELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYV 776
D GV +L PC L L N I+D G+ L E + + L L+NN++TD A +
Sbjct: 804 DIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSM 863
Query: 777 TKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEAL 836
K+L + L+LG N IT+ G + LA ++ + S+ +G WGN+VGDEGA+A AEAL
Sbjct: 864 AKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEAL 923
Query: 837 RNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQ 896
+H SL LSL N I + G ++LA L +N LE L L +N L DE SLAE LK N
Sbjct: 924 GDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNS 983
Query: 897 TLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEE 940
+LK L L N IT G L AL+ N I E+ L GN EE
Sbjct: 984 SLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGNTFSLEE 1027
Score = 50.8 bits (120), Expect = 6e-06
Identities = 46/155 (29%), Positives = 65/155 (41%), Gaps = 3/155 (1%)
Query: 788 HLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSL 847
HLKL + LA +++ + + + N VGD G + L L L
Sbjct: 766 HLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLG---VCKALYL 822
Query: 848 ASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQ 907
N IS G L L+ L L N+L D A S+A++L Q L L N
Sbjct: 823 RDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNY 882
Query: 908 ITAKGTAQLADALQSNTGITEICLNGNLIKPEEAK 942
ITA G LA+ L+ NT + + GN + E A+
Sbjct: 883 ITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQ 917
>gi|118918429 NOD3 protein [Homo sapiens]
Length = 1065
Score = 190 bits (483), Expect = 5e-48
Identities = 212/782 (27%), Positives = 338/782 (43%), Gaps = 85/782 (10%)
Query: 201 LGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFSCFKESDRLCLQDLL---FKH 257
+G AG+GK+ L++ LWA G++ K F F ++LC L+ F H
Sbjct: 144 IGVAGMGKTTLVRHFVRLWAHGQVG---KDFSLVLPLTFRDLNTHEKLCADRLICSVFPH 200
Query: 258 YCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHPLVLLANL 317
P + + P AL DGLDE + LD S + P + L+ N+
Sbjct: 201 VGEP--------SLAVAVPARALLILDGLDECRTPLDFSNTVACTDPKKEIPVDHLITNI 252
Query: 318 LSGKLLKGASKLLTARTGI--EVPRQFLRKKVLLRGFSPSHLRAYARRMFPE-RALQDRL 374
+ G L S +T+R ++P + + +RGF+ ++ +MFPE +AL +
Sbjct: 253 IRGNLFPEVSIWITSRPSASGQIPGGLVDRMTEIRGFNEEEIKVCLEQMFPEDQALLGWM 312
Query: 375 LSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDC--TMTLTDVFLLVTEVH 432
LSQ++A+ L +C+VP FC + H + G PQ + TL +++ +
Sbjct: 313 LSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTG-PQDAELWPPRTLCELYSWYFRMA 371
Query: 433 LNRMQPSSLVQRNTRSP--VETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQASGLQE 490
L+ ++ SP + H GR + +LG++A G+ K +VF +++++A G+
Sbjct: 372 LS----GEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVDL 427
Query: 491 RDMQLG----FLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQE 546
+Q FL+ L +Y F HL+LQ F A + R +L
Sbjct: 428 ALLQGAPCSCFLQREETLA---SSVAYCFTHLSLQEFVAAAYYYGASRRAIFDLFTESGV 484
Query: 547 WMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQKLLRH 606
P G T Q G R D+F FL GLLS LL
Sbjct: 485 SWPRLGFLTHFRSAAQRAMQAEDG----RLDVFLR---------FLSGLLSPRVNALLAG 531
Query: 607 LVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLRCIYETQSQK 666
+ A + + A L L+G L+ V + N +L C++E Q +
Sbjct: 532 SLLAQGEHQAYRTQVAEL---LQGCLRPDAAVCARAIN----------VLHCLHELQHTE 578
Query: 667 V----------GQLAARGICANYLKLTYCNACSADCSA---LSFVLHH------FPKRL- 706
+ G LA A+ L Y S C+ LS L P+ L
Sbjct: 579 LARSVEEAMESGALARLTGPAHRAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLLY 638
Query: 707 --ALDLDNNNLNDYGVRELQPCFS----RLTVLRLSVNQITDGGVKVLSEELTKYKIVTY 760
L LD N D + L S R+ + L+ NQI++ G K L+ L + +T
Sbjct: 639 CRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTS 698
Query: 761 LGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMW 820
L L N I GA+ + L + LT L L N + +G + +A A+ +++++S + +
Sbjct: 699 LDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQ 758
Query: 821 GNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNEL 880
N +G GA+ A+AL+ + SL L +SN I G K+LA AL+ N LE L L N +
Sbjct: 759 KNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSI 818
Query: 881 NDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEE 940
+D +L L NQTL L L +N I+ +G +A AL +N+ + + L NL+ +
Sbjct: 819 SDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQG 878
Query: 941 AK 942
A+
Sbjct: 879 AR 880
Score = 117 bits (292), Expect = 7e-26
Identities = 78/238 (32%), Positives = 120/238 (50%), Gaps = 3/238 (1%)
Query: 707 ALDLDNNNLNDYGVRELQPCFS---RLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGL 763
+LDL N++ G + L LT L L N + D G + ++E L + ++ L L
Sbjct: 698 SLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHL 757
Query: 764 YNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQ 823
N I +GA+ + L + + L L N I G K LA A+K ++ + + + N
Sbjct: 758 QKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNS 817
Query: 824 VGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDE 883
+ D G A AL + +L +LSL N IS EG +++A AL N++L+ L LT N L+D+
Sbjct: 818 ISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQ 877
Query: 884 VAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEA 941
A ++A ++ N+TL L L N I A L ALQ N +T + L N I + A
Sbjct: 878 GARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGA 935
Score = 110 bits (275), Expect = 6e-24
Identities = 79/246 (32%), Positives = 123/246 (50%), Gaps = 3/246 (1%)
Query: 708 LDLDNNNLNDYGVRELQPCFSR---LTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLY 764
L L N++ G + + + L L S N I DGG K L+E L + + L L
Sbjct: 755 LHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQ 814
Query: 765 NNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQV 824
+N I+D G + L + L L L +N I+ EG + +A A+ + ++ + + N +
Sbjct: 815 SNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLL 874
Query: 825 GDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEV 884
D+GA+A A A+R + +LT+L L N I ++L +ALQ N SL L L +N + D+
Sbjct: 875 HDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDG 934
Query: 885 AESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKVY 944
A ++A LKVN L L+L I A G L +AL N + + L GN I AK
Sbjct: 935 ACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKAL 994
Query: 945 EDEKRI 950
+ ++
Sbjct: 995 ANALKV 1000
Score = 110 bits (275), Expect = 6e-24
Identities = 80/243 (32%), Positives = 126/243 (51%), Gaps = 3/243 (1%)
Query: 707 ALDLDNNNLNDYGVRELQPCF-SRLTVLRLSV--NQITDGGVKVLSEELTKYKIVTYLGL 763
+LDL +N+++D GV L + T+L LS+ N I+ G + ++ L + L L
Sbjct: 810 SLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDL 869
Query: 764 YNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQ 823
N + D GAR + + E + LT L L N I + + L A++ ++S++ + + N
Sbjct: 870 TANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENA 929
Query: 824 VGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDE 883
+GD+GA A A AL+ + +LT L L I G + L AL N +LEIL L N +
Sbjct: 930 IGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVA 989
Query: 884 VAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKV 943
A++LA LKVN +L+ L L +N + G +A AL N + I L GN I A++
Sbjct: 990 GAKALANALKVNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARM 1049
Query: 944 YED 946
+
Sbjct: 1050 ISE 1052
Score = 102 bits (254), Expect = 2e-21
Identities = 72/230 (31%), Positives = 117/230 (50%), Gaps = 3/230 (1%)
Query: 708 LDLDNNNLNDYGVRELQPCFS---RLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLY 764
L +N++ D G + L L L L N I+D GV L L + + L L
Sbjct: 783 LMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLR 842
Query: 765 NNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQV 824
N I+ GA+ + L L +L L N + +G + +A+AV+ +++++ + + N +
Sbjct: 843 ENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFI 902
Query: 825 GDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEV 884
A+A +AL+ + SLT+L L N I +G ++ARAL+ NT+L L+L +
Sbjct: 903 QAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASG 962
Query: 885 AESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGN 934
A+ L E L VN+TL+ L L N I G LA+AL+ N+ + + L N
Sbjct: 963 AQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQEN 1012
Score = 87.0 bits (214), Expect = 7e-17
Identities = 51/137 (37%), Positives = 78/137 (56%)
Query: 814 ISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEIL 873
I ++ + NQ+ ++GAKA A +L + SLT+L L N I +G K+LA AL+ N +L L
Sbjct: 668 IQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSL 727
Query: 874 WLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNG 933
L N + D+ A S+AE L N+TL L L +N I G ++ADAL+ N + E+ +
Sbjct: 728 SLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSS 787
Query: 934 NLIKPEEAKVYEDEKRI 950
N I AK + ++
Sbjct: 788 NSIGDGGAKALAEALKV 804
Score = 63.5 bits (153), Expect = 9e-10
Identities = 41/144 (28%), Positives = 66/144 (45%), Gaps = 3/144 (2%)
Query: 707 ALDLDNNNLNDYG---VRELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGL 763
+LDL N + D G V + LT L L V I G +VL E L + + L L
Sbjct: 922 SLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDL 981
Query: 764 YNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQ 823
N I GA+ + L L L L +N + +G +A A+ + + + + GN
Sbjct: 982 RGNAIGVAGAKALANALKVNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNH 1041
Query: 824 VGDEGAKAFAEALRNHPSLTTLSL 847
+GD GA+ +EA++ + T+ +
Sbjct: 1042 IGDSGARMISEAIKTNAPTCTVEM 1065
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 166 bits (420), Expect = 1e-40
Identities = 199/763 (26%), Positives = 315/763 (41%), Gaps = 97/763 (12%)
Query: 193 EQGETIFILGDAGVGKSMLLQRLQSLWATGRLDAG-VKFFFHFRCRMFSCFKESDRLCLQ 251
E T+ + G AG+GKSML ++ WA G+L G + F+ CR + + + +Q
Sbjct: 208 EPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMN--QSATECSMQ 265
Query: 252 DLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHPL 311
DL+F C+PE P L+R P LF DG DEL + P C WE P
Sbjct: 266 DLIFS--CWPE--PSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLC-WEEKRPT 320
Query: 312 VLLAN-LLSGKLLKGASKLLTAR-TGIEVPRQFLR--KKVLLRGFSPSHLRAYARRMFPE 367
LL N L+ KLL S L+T R T +E + L + V + GFS + + Y + F
Sbjct: 321 ELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHN 380
Query: 368 RALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTLTDVFLL 427
++ + + N L ++C VPL CW++ C Q EG L + T T V++L
Sbjct: 381 AEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQ---QLEGGGLLRQTSRTTTAVYML 437
Query: 428 VTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQASG 487
L+ MQP R P + LCSL A G+ +F +++++ G
Sbjct: 438 YL---LSLMQPKPGAPRLQPPP------NQRGLCSL---AADGLWNQKILFEEQDLRKHG 485
Query: 488 LQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVG----TQELLRF 543
L D+ FL ++ Y F HL+ Q FF A + +LD+ G Q++ R
Sbjct: 486 LDGEDVS-AFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQDVTRL 544
Query: 544 FQEWMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQKL 603
E+ F + T+ FL GLL++ +
Sbjct: 545 LTEY------------------------------AFSERSFLALTSRFLFGLLNEETRS- 573
Query: 604 LRHLVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLRCIYETQ 663
HL + + + H+ L +++S + Q + Q F C+YE Q
Sbjct: 574 --HLEKSLCWK-----VSPHIKMDLLQWIQS--KAQSDGSTLQQGSLEF---FSCLYEIQ 621
Query: 664 SQKVGQLAARGI-------CANYLKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLN 716
++ Q A A+ ++ + C C + VLH + + D ++
Sbjct: 622 EEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQ-VLHLYGATYSADGEDRARC 680
Query: 717 DYGVRELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYV 776
G L TVL D + L+ L + L LY N + G + +
Sbjct: 681 SAGAHTLLVQLPERTVL-------LDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLL 733
Query: 777 TKIL--DECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAE 834
+ L CK L +L+L + +I+S + L+ A+ +K+++ + + GN VG G E
Sbjct: 734 CQGLRHPNCK-LQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCE 792
Query: 835 ALRNHPS--LTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEML 892
LR HP L + L + + + +A L N L L LT N L D L + L
Sbjct: 793 GLR-HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGL 851
Query: 893 KVNQ-TLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGN 934
+ L+ LWL ++TA +LA L N + E+ L+ N
Sbjct: 852 RHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLN 894
Score = 71.2 bits (173), Expect = 4e-12
Identities = 71/252 (28%), Positives = 118/252 (46%), Gaps = 21/252 (8%)
Query: 680 LKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVR----ELQPCFSRLTVLRL 735
++L C S C ++ VL P + LDL N L D G+R L+ RL L L
Sbjct: 804 IQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWL 863
Query: 736 SVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTH------- 788
+ ++T L+ L+ + + L L N++ D+G +L C+GL H
Sbjct: 864 KICRLTAAACDELASTLSVNQSLRELDLSLNELGDLG------VLLLCEGLRHPTCKLQT 917
Query: 789 LKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPS--LTTLS 846
L+LG ++ S + L++ ++ + ++ E+ + N +GD G AE L+ HP+ L L
Sbjct: 918 LRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQ-HPACRLQKLW 976
Query: 847 LASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLK-VNQTLKHLWLIQ 905
L S G++ + ++L L N +L L+LT N L D L + L L+ LWL
Sbjct: 977 LDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFG 1036
Query: 906 NQITAKGTAQLA 917
+ ++LA
Sbjct: 1037 MDLNKMTHSRLA 1048
Score = 70.5 bits (171), Expect = 7e-12
Identities = 76/271 (28%), Positives = 120/271 (44%), Gaps = 21/271 (7%)
Query: 680 LKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGV----RELQPCFSRLTVLRL 735
L+L C S+ C LS L +DL N + G+ L+ RL +++L
Sbjct: 747 LRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQL 806
Query: 736 SVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTH------- 788
Q+ G + ++ L + L L N + D+G R + C+GL H
Sbjct: 807 RKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLL------CQGLRHPVCRLRT 860
Query: 789 LKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPS--LTTLS 846
L L ++T+ LA + ++S+ E+ + N++GD G E LR HP+ L TL
Sbjct: 861 LWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLR-HPTCKLQTLR 919
Query: 847 LASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQT-LKHLWLIQ 905
L + + + L+ LQ N +L L L+ N+L D LAE L+ L+ LWL
Sbjct: 920 LGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDS 979
Query: 906 NQITAKGTAQLADALQSNTGITEICLNGNLI 936
+TAK L L N +T++ L N +
Sbjct: 980 CGLTAKACENLYFTLGINQTLTDLYLTNNAL 1010
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 147 bits (370), Expect = 6e-35
Identities = 189/774 (24%), Positives = 328/774 (42%), Gaps = 80/774 (10%)
Query: 192 NEQGETIFILGDAGVGKSMLLQRLQSLWATGRL-DAGVKFFFHFRCRMFSCFKESDRLCL 250
+E T+ G AG+GK++L +++ WA+G L + F+ CR S + L
Sbjct: 216 SEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRS---L 272
Query: 251 QDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHP 310
DL+ C P DP ++R P LF DG DEL D + W+ A
Sbjct: 273 GDLIMS--CCP--DPNPPIHKIVRKPSRILFLMDGFDELQGAFD-EHIGPLCTDWQKAER 327
Query: 311 L-VLLANLLSGKLLKGASKLLTAR-TGIEVPRQFLR--KKVLLRGFSPSHLRAYARRMFP 366
+LL++L+ KLL AS L+T R +E + L + V + GFS + + Y + F
Sbjct: 328 GDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFS 387
Query: 367 ERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTLTDVFL 426
+ A S ++ N L ++C +PL CWI+ + E L + T T V++
Sbjct: 388 DEAQARAAFSLIQENEVLFTMCFIPLVCWIV---CTGLKQQMESGKSLAQTSKTTTAVYV 444
Query: 427 LVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQAS 486
SSL+Q S L A LCSL A G+ +F + +++
Sbjct: 445 FFL---------SSLLQPRGGSQEHGLCAHLWGLCSL---AADGIWNQKILFEESDLRNH 492
Query: 487 GLQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQE 546
GLQ+ D+ FLR ++ Y F H+T Q FF A + +L++ + + +
Sbjct: 493 GLQKADVS-AFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRL 551
Query: 547 WMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQKLLRH 606
+P L+ G K + F FL GL+++ + L
Sbjct: 552 KLPSRDVTV-----------LLENYGKF------EKGYLIFVVRFLFGLVNQERTSYL-- 592
Query: 607 LVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVES-FNQVQAMPTFIWMLRCIYETQSQ 665
K L + +R L+ L ++V++ ++Q P+ + + C+YE Q +
Sbjct: 593 ----------EKKLSCKISQQIR--LELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEE 640
Query: 666 KVGQLAA---------RGICANYLKLTYC--NACSADCSALSFVLHHFPKRLALDLDNNN 714
Q A +++ ++C N + +L F LH+ PK +
Sbjct: 641 DFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGF-LHNMPKEEEEEEKEGR 699
Query: 715 LNDYGVRELQPCFSRLTVLRLSVN-QITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGA 773
D V+ + P S VN +T + L L+ + +T L L +N + D G
Sbjct: 700 HLDM-VQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGM 758
Query: 774 RYVTKILDE--CKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKA 831
R + + L C + L LG+ ++ E ++L + +++ + E+ + N +GD G +
Sbjct: 759 RVLCETLQHPGC-NIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRL 817
Query: 832 FAEALRN-HPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAE 890
L++ +L L L S +++ + LA L + SL L++ +N L D L E
Sbjct: 818 LCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCE 877
Query: 891 MLKVNQ-TLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKV 943
K Q L+ L L+ + +T+ + L+ L +N +T + L GN + + K+
Sbjct: 878 KAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKL 931
Score = 61.6 bits (148), Expect = 3e-09
Identities = 76/318 (23%), Positives = 138/318 (43%), Gaps = 33/318 (10%)
Query: 630 GYLKSLPRVQVESFNQVQAMPTFIWMLRCIYETQSQKVGQLAARGICANYLKLTYCNACS 689
G+L ++P+ + E + + + M++C+ + S + G+ ++L ++C
Sbjct: 682 GFLHNMPKEEEEEEKEGRHLD----MVQCVLPSSSHAA---CSHGLVNSHLTSSFCRG-- 732
Query: 690 ADCSALSFVLHHFPKRLALDLDNNNLNDYGVR----ELQPCFSRLTVLRLSVNQITDGGV 745
L VL LDL +N+L D G+R LQ + L L ++
Sbjct: 733 -----LFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECC 787
Query: 746 KVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNK-------ITS 798
+S L+ + + L L +N + D G R + C GL HL K +TS
Sbjct: 788 FDISLVLSSNQKLVELDLSDNALGDFGIRLL------CVGLKHLLCNLKKLWLVSCCLTS 841
Query: 799 EGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRN-HPSLTTLSLASNGISTEGG 857
+ LA + S S++ + + N +GD G E +N +L L L ++G+++
Sbjct: 842 ACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCC 901
Query: 858 KSLARALQQNTSLEILWLTQNELNDEVAESLAE-MLKVNQTLKHLWLIQNQITAKGTAQL 916
+L+ L N +L L+L N L D+ + L E +L + L+ L L +T+ L
Sbjct: 902 SALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDL 961
Query: 917 ADALQSNTGITEICLNGN 934
+ L S+ + ++ L N
Sbjct: 962 STLLTSSQSLRKLSLGNN 979
Score = 60.1 bits (144), Expect = 1e-08
Identities = 65/261 (24%), Positives = 106/261 (40%), Gaps = 32/261 (12%)
Query: 680 LKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVRELQPCFSRLTVLRLSVNQ 739
L L C C +S VL K + LDL +N L D+G+R L C
Sbjct: 775 LWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLL--CV------------ 820
Query: 740 ITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSE 799
G+K L L K L L + +T + + +L LT L +G+N +
Sbjct: 821 ----GLKHLLCNLKK------LWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDS 870
Query: 800 GGKYLALAVKNSK-SISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGK 858
G L KN + ++ ++G+ + + A + L + +LT L L N + +G K
Sbjct: 871 GVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIK 930
Query: 859 SLARA-LQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLA 917
L L + L++L L L L+ +L +Q+L+ L L N + G
Sbjct: 931 LLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFC 990
Query: 918 DALQ------SNTGITEICLN 932
+ L+ N G++E+ N
Sbjct: 991 EVLKQQSCLLQNLGLSEMYFN 1011
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 147 bits (370), Expect = 6e-35
Identities = 189/774 (24%), Positives = 328/774 (42%), Gaps = 80/774 (10%)
Query: 192 NEQGETIFILGDAGVGKSMLLQRLQSLWATGRL-DAGVKFFFHFRCRMFSCFKESDRLCL 250
+E T+ G AG+GK++L +++ WA+G L + F+ CR S + L
Sbjct: 216 SEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRS---L 272
Query: 251 QDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHP 310
DL+ C P DP ++R P LF DG DEL D + W+ A
Sbjct: 273 GDLIMS--CCP--DPNPPIHKIVRKPSRILFLMDGFDELQGAFD-EHIGPLCTDWQKAER 327
Query: 311 L-VLLANLLSGKLLKGASKLLTAR-TGIEVPRQFLR--KKVLLRGFSPSHLRAYARRMFP 366
+LL++L+ KLL AS L+T R +E + L + V + GFS + + Y + F
Sbjct: 328 GDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFS 387
Query: 367 ERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTLTDVFL 426
+ A S ++ N L ++C +PL CWI+ + E L + T T V++
Sbjct: 388 DEAQARAAFSLIQENEVLFTMCFIPLVCWIV---CTGLKQQMESGKSLAQTSKTTTAVYV 444
Query: 427 LVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQAS 486
SSL+Q S L A LCSL A G+ +F + +++
Sbjct: 445 FFL---------SSLLQPRGGSQEHGLCAHLWGLCSL---AADGIWNQKILFEESDLRNH 492
Query: 487 GLQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQE 546
GLQ+ D+ FLR ++ Y F H+T Q FF A + +L++ + + +
Sbjct: 493 GLQKADVS-AFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRL 551
Query: 547 WMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQKLLRH 606
+P L+ G K + F FL GL+++ + L
Sbjct: 552 KLPSRDVTV-----------LLENYGKF------EKGYLIFVVRFLFGLVNQERTSYL-- 592
Query: 607 LVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVES-FNQVQAMPTFIWMLRCIYETQSQ 665
K L + +R L+ L ++V++ ++Q P+ + + C+YE Q +
Sbjct: 593 ----------EKKLSCKISQQIR--LELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEE 640
Query: 666 KVGQLAA---------RGICANYLKLTYC--NACSADCSALSFVLHHFPKRLALDLDNNN 714
Q A +++ ++C N + +L F LH+ PK +
Sbjct: 641 DFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGF-LHNMPKEEEEEEKEGR 699
Query: 715 LNDYGVRELQPCFSRLTVLRLSVN-QITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGA 773
D V+ + P S VN +T + L L+ + +T L L +N + D G
Sbjct: 700 HLDM-VQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGM 758
Query: 774 RYVTKILDE--CKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKA 831
R + + L C + L LG+ ++ E ++L + +++ + E+ + N +GD G +
Sbjct: 759 RVLCETLQHPGC-NIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRL 817
Query: 832 FAEALRN-HPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAE 890
L++ +L L L S +++ + LA L + SL L++ +N L D L E
Sbjct: 818 LCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCE 877
Query: 891 MLKVNQ-TLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKV 943
K Q L+ L L+ + +T+ + L+ L +N +T + L GN + + K+
Sbjct: 878 KAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKL 931
Score = 61.6 bits (148), Expect = 3e-09
Identities = 76/318 (23%), Positives = 138/318 (43%), Gaps = 33/318 (10%)
Query: 630 GYLKSLPRVQVESFNQVQAMPTFIWMLRCIYETQSQKVGQLAARGICANYLKLTYCNACS 689
G+L ++P+ + E + + + M++C+ + S + G+ ++L ++C
Sbjct: 682 GFLHNMPKEEEEEEKEGRHLD----MVQCVLPSSSHAA---CSHGLVNSHLTSSFCRG-- 732
Query: 690 ADCSALSFVLHHFPKRLALDLDNNNLNDYGVR----ELQPCFSRLTVLRLSVNQITDGGV 745
L VL LDL +N+L D G+R LQ + L L ++
Sbjct: 733 -----LFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECC 787
Query: 746 KVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNK-------ITS 798
+S L+ + + L L +N + D G R + C GL HL K +TS
Sbjct: 788 FDISLVLSSNQKLVELDLSDNALGDFGIRLL------CVGLKHLLCNLKKLWLVSCCLTS 841
Query: 799 EGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRN-HPSLTTLSLASNGISTEGG 857
+ LA + S S++ + + N +GD G E +N +L L L ++G+++
Sbjct: 842 ACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCC 901
Query: 858 KSLARALQQNTSLEILWLTQNELNDEVAESLAE-MLKVNQTLKHLWLIQNQITAKGTAQL 916
+L+ L N +L L+L N L D+ + L E +L + L+ L L +T+ L
Sbjct: 902 SALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDL 961
Query: 917 ADALQSNTGITEICLNGN 934
+ L S+ + ++ L N
Sbjct: 962 STLLTSSQSLRKLSLGNN 979
Score = 60.1 bits (144), Expect = 1e-08
Identities = 65/261 (24%), Positives = 106/261 (40%), Gaps = 32/261 (12%)
Query: 680 LKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVRELQPCFSRLTVLRLSVNQ 739
L L C C +S VL K + LDL +N L D+G+R L C
Sbjct: 775 LWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLL--CV------------ 820
Query: 740 ITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSE 799
G+K L L K L L + +T + + +L LT L +G+N +
Sbjct: 821 ----GLKHLLCNLKK------LWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDS 870
Query: 800 GGKYLALAVKNSK-SISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGK 858
G L KN + ++ ++G+ + + A + L + +LT L L N + +G K
Sbjct: 871 GVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIK 930
Query: 859 SLARA-LQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLA 917
L L + L++L L L L+ +L +Q+L+ L L N + G
Sbjct: 931 LLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFC 990
Query: 918 DALQ------SNTGITEICLN 932
+ L+ N G++E+ N
Sbjct: 991 EVLKQQSCLLQNLGLSEMYFN 1011
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 138 bits (348), Expect = 2e-32
Identities = 185/765 (24%), Positives = 324/765 (42%), Gaps = 80/765 (10%)
Query: 192 NEQGETIFILGDAGVGKSMLLQRLQSLWATGRL-DAGVKFFFHFRCRMFSCFKESDRLCL 250
+E T+ G AG+GK++L +++ WA+G L + F+ CR S + L
Sbjct: 216 SEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRS---L 272
Query: 251 QDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHP 310
DL+ C P DP ++R P LF DG DEL D + W+ A
Sbjct: 273 GDLIMS--CCP--DPNPPIHKIVRKPSRILFLMDGFDELQGAFD-EHIGPLCTDWQKAER 327
Query: 311 L-VLLANLLSGKLLKGASKLLTAR-TGIEVPRQFLR--KKVLLRGFSPSHLRAYARRMFP 366
+LL++L+ KLL AS L+T R +E + L + V + GFS + + Y + F
Sbjct: 328 GDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFS 387
Query: 367 ERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTLTDVFL 426
+ A S ++ N L ++C +PL CWI+ + E L + T T V++
Sbjct: 388 DEAQARAAFSLIQENEVLFTMCFIPLVCWIV---CTGLKQQMESGKSLAQTSKTTTAVYV 444
Query: 427 LVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQAS 486
SSL+Q S L A LCSL A G+ +F + +++
Sbjct: 445 FFL---------SSLLQPRGGSQEHGLCAHLWGLCSL---AADGIWNQKILFEESDLRNH 492
Query: 487 GLQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQE 546
GLQ+ D+ FLR ++ Y F H+T Q FF A + +L++ + + +
Sbjct: 493 GLQKADVS-AFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRL 551
Query: 547 WMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQKLLRH 606
+P L+ G K + F FL GL+++ + L
Sbjct: 552 KLPSRDVTV-----------LLENYGKF------EKGYLIFVVRFLFGLVNQERTSYL-- 592
Query: 607 LVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVES-FNQVQAMPTFIWMLRCIYETQSQ 665
K L + +R L+ L ++V++ ++Q P+ + + C+YE Q +
Sbjct: 593 ----------EKKLSCKISQQIR--LELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEE 640
Query: 666 KVGQLAA---------RGICANYLKLTYC--NACSADCSALSFVLHHFPKRLALDLDNNN 714
Q A +++ ++C N + +L F LH+ PK +
Sbjct: 641 DFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGF-LHNMPKEEEEEEKEGR 699
Query: 715 LNDYGVRELQPCFSRLTVLRLSVN-QITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGA 773
D V+ + P S VN +T + L L+ + +T L L +N + D G
Sbjct: 700 HLDM-VQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGM 758
Query: 774 RYVTKILDE--CKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKA 831
R + + L C + L LG+ ++ E ++L + +++ + E+ + N +GD G +
Sbjct: 759 RVLCETLQHPGC-NIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRL 817
Query: 832 FAEALRN-HPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAE 890
L++ +L L L ++G+++ +L+ L N +L L+L N L D+ + L E
Sbjct: 818 LCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCE 877
Query: 891 -MLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGN 934
+L + L+ L L +T+ L+ L S+ + ++ L N
Sbjct: 878 GLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNN 922
Score = 57.0 bits (136), Expect = 8e-08
Identities = 45/156 (28%), Positives = 76/156 (48%), Gaps = 4/156 (2%)
Query: 791 LGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHP--SLTTLSLA 848
L + +TS + L + S+S++E+ + N +GD G + E L+ HP ++ L L
Sbjct: 720 LVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQ-HPGCNIRRLWLG 778
Query: 849 SNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLK-VNQTLKHLWLIQNQ 907
G+S E ++ L N L L L+ N L D L LK + LK LWL+ +
Sbjct: 779 RCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSG 838
Query: 908 ITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKV 943
+T+ + L+ L +N +T + L GN + + K+
Sbjct: 839 LTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKL 874
Score = 56.6 bits (135), Expect = 1e-07
Identities = 54/207 (26%), Positives = 90/207 (43%), Gaps = 18/207 (8%)
Query: 680 LKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVR----ELQPCFSRLTVLRL 735
L L C C +S VL K + LDL +N L D+G+R L+ L L L
Sbjct: 775 LWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWL 834
Query: 736 SVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTH------- 788
+ +T LS L+ + +T+L L N + D G + + C+GL H
Sbjct: 835 VNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLL------CEGLLHPDCKLQV 888
Query: 789 LKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPS-LTTLSL 847
L+L +TS L+ + +S+S+ ++ + N +GD G F E L+ L L L
Sbjct: 889 LELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 948
Query: 848 ASNGISTEGGKSLARALQQNTSLEILW 874
+ + E +L ++ L +++
Sbjct: 949 SEMYFNYETKSALETLQEEKPELTVVF 975
Score = 53.9 bits (128), Expect = 7e-07
Identities = 68/282 (24%), Positives = 119/282 (42%), Gaps = 34/282 (12%)
Query: 630 GYLKSLPRVQVESFNQVQAMPTFIWMLRCIYETQSQKVGQLAARGICANYLKLTYCNACS 689
G+L ++P+ + E + + + M++C+ + S + G+ ++L ++C
Sbjct: 682 GFLHNMPKEEEEEEKEGRHLD----MVQCVLPSSSHAA---CSHGLVNSHLTSSFCRG-- 732
Query: 690 ADCSALSFVLHHFPKRLALDLDNNNLNDYGVR----ELQPCFSRLTVLRLSVNQITDGGV 745
L VL LDL +N+L D G+R LQ + L L ++
Sbjct: 733 -----LFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECC 787
Query: 746 KVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNK-------ITS 798
+S L+ + + L L +N + D G R + C GL HL K +TS
Sbjct: 788 FDISLVLSSNQKLVELDLSDNALGDFGIRLL------CVGLKHLLCNLKKLWLVNSGLTS 841
Query: 799 EGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHP--SLTTLSLASNGISTEG 856
L+ + +++++ + + GN +GD+G K E L HP L L L + +++
Sbjct: 842 VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLL-HPDCKLQVLELDNCNLTSHC 900
Query: 857 GKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTL 898
L+ L + SL L L N+L D E+LK L
Sbjct: 901 CWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCL 942
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 137 bits (345), Expect = 5e-32
Identities = 187/796 (23%), Positives = 324/796 (40%), Gaps = 112/796 (14%)
Query: 192 NEQGETIFILGDAGVGKSMLLQRLQSLWATGRL-DAGVKFFFHFRCRMFSCFKESDRLCL 250
+E T+ G AG+GK++L +++ WA+G L + F+ CR S + L
Sbjct: 216 SEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRS---L 272
Query: 251 QDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHP 310
DL+ C P DP ++R P LF DG DEL D + W+ A
Sbjct: 273 GDLIMS--CCP--DPNPPIHKIVRKPSRILFLMDGFDELQGAFD-EHIGPLCTDWQKAER 327
Query: 311 L-VLLANLLSGKLLKGASKLLTAR-TGIEVPRQFLR--KKVLLRGFSPSHLRAYARRMFP 366
+LL++L+ KLL AS L+T R +E + L + V + GFS + + Y + F
Sbjct: 328 GDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFS 387
Query: 367 ERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTLTDVFL 426
+ A S ++ N L ++C +PL CWI+ + E L + T T V++
Sbjct: 388 DEAQARAAFSLIQENEVLFTMCFIPLVCWIV---CTGLKQQMESGKSLAQTSKTTTAVYV 444
Query: 427 LVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQAS 486
SSL+Q S L A LCSL A G+ +F + +++
Sbjct: 445 FFL---------SSLLQPRGGSQEHGLCAHLWGLCSL---AADGIWNQKILFEESDLRNH 492
Query: 487 GLQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQE 546
GLQ+ D+ FLR ++ Y F H+T Q FF A + +L++ + + +
Sbjct: 493 GLQKADVS-AFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRL 551
Query: 547 WMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQKLLRH 606
+P L+ G K + F FL GL+++ + L
Sbjct: 552 KLPSRDVTV-----------LLENYGKF------EKGYLIFVVRFLFGLVNQERTSYL-- 592
Query: 607 LVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVES-FNQVQAMPTFIWMLRCIYETQSQ 665
K L + +R L+ L ++V++ ++Q P+ + + C+YE Q +
Sbjct: 593 ----------EKKLSCKISQQIR--LELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEE 640
Query: 666 KVGQLAA---------RGICANYLKLTYC--NACSADCSALSFVLHHFPK---------- 704
Q A +++ ++C N + +L F LH+ PK
Sbjct: 641 DFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGF-LHNMPKEEEEEEKEGR 699
Query: 705 -----RLALDLDNNNLNDYGVREL----QPCF---------SRLTVLRLSVNQITDGGVK 746
+ L ++ +G+ + CF +L L LS N + D G++
Sbjct: 700 HLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIR 759
Query: 747 VLSEELTKYKI--VTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYL 804
+L L K+ + + L L + +T + + +L LT L +G+N + G L
Sbjct: 760 LLCVGL-KHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAIL 818
Query: 805 ALAVKNSK-SISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARA 863
KN + ++ ++G+ + + A + L + +LT L L N + +G K L
Sbjct: 819 CEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEG 878
Query: 864 -LQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQ- 921
L + L++L L L L+ +L +Q+L+ L L N + G + L+
Sbjct: 879 LLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQ 938
Query: 922 -----SNTGITEICLN 932
N G++E+ N
Sbjct: 939 QSCLLQNLGLSEMYFN 954
>gi|116268109 nucleotide-binding oligomerization domains 27 [Homo
sapiens]
Length = 1866
Score = 132 bits (333), Expect = 1e-30
Identities = 184/778 (23%), Positives = 287/778 (36%), Gaps = 130/778 (16%)
Query: 191 LNEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDA-GVKFFFHFR-CRMFSCFKESDRL 248
+N+ +LG AG+GK+ L RL WA G L+ F F FR + + F L
Sbjct: 217 VNKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLNCFQALFLFEFRQLNLITRF-----L 271
Query: 249 CLQDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPA 308
+LLF Y PE D + VF +L + L FDGLDE + PD P
Sbjct: 272 TPSELLFDLYLSPESDHDTVFQYLEKNADQVLLIFDGLDEALQPMG----PDG-----PG 322
Query: 309 HPLVLLANLLSGKLLKGASKLLTARTGIEVPRQFLRKKVLLR--GFSPSHLRAYARRMFP 366
L L ++L +G LL G + T+R G ++P + ++ GF + Y F
Sbjct: 323 PVLTLFSHLCNGTLLPGCRVMATSRPG-KLPACLPAEAAMVHMLGFDGPRVEEYVNHFFS 381
Query: 367 ERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHF---RAAFEGSPQLPDCTMTLTD 423
+ ++ L +L+ N L SLC+VP C + C H A + LP+ T
Sbjct: 382 AQPSREGALVELQTNGRLRSLCAVPALCQVACLCLHHLLPDHAPGQSVALLPNMTQLYMQ 441
Query: 424 VFLLVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEV 483
+ L ++ H +L LG+VA RG+E +F +++
Sbjct: 442 MVLALSPPG---------------------HLPTSSLLDLGEVALRGLETGKVIFYAKDI 480
Query: 484 QASGLQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRF 543
+ GPG Q Y F HL+LQ F A L+ +V L ++
Sbjct: 481 APPLIAFGATHSLLTSFCVCTGPGHQQTGYAFTHLSLQEFLAALHLMASPKVNKDTLTQY 540
Query: 544 FQEWMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQKL 603
L + +Q + AR L DH FL GL S +
Sbjct: 541 VT-----------------LHSRWVQRT-KARLGL---SDHLP---TFLAGLASCTCRPF 576
Query: 604 LRHLVPAA--ALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLRCIYE 661
L HL + K+ A+ LK L ++ P + + C+ E
Sbjct: 577 LSHLAQGNEDCVGAKQAAVVQ--------VLKKLATRKLTG-------PKVVELCHCVDE 621
Query: 662 TQSQKVGQLAARGICANYLKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVR 721
TQ ++ L A+ + + C+ D + L+ +L H + LD D L +
Sbjct: 622 TQEPELASLTAQSLPYQLPFHNFPLTCT-DLATLTNILEHREAPIHLDFDGCPLEPHCPE 680
Query: 722 ELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILD 781
L C ++ L + D + LS L + LGL ++IT G ++ K L
Sbjct: 681 ALVGC-GQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALP 739
Query: 782 ECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPS 841
C + EV NQ+ D+ E L + P
Sbjct: 740 LC----------------------------PQLKEVSFRDNQLSDQVVLNIVEVLPHLPR 771
Query: 842 LTTLSLASNGISTEGGKSLARA--------LQQNTSLEILWL------TQNELN--DEVA 885
L L L+SN I LAR + Q ++++L T EL ++
Sbjct: 772 LRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQ 831
Query: 886 ESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKV 943
ES + L L + Q+ L LQ + E+ L+GN ++ E ++
Sbjct: 832 ESDGQRKGAQSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRL 889
Score = 82.4 bits (202), Expect = 2e-15
Identities = 80/274 (29%), Positives = 119/274 (43%), Gaps = 8/274 (2%)
Query: 667 VGQLAARGICANYLKLTYCNACSADCSA---LSFVLHHFPKRLALDLDNNNLNDYGVREL 723
VGQL L L+ N C D ++ L +L + L ++ ++ G+ L
Sbjct: 1455 VGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHL 1514
Query: 724 QPCFSR---LTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKIL 780
L L LS NQ + G K L L ++ L L + + +T L
Sbjct: 1515 ASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRL 1574
Query: 781 DECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHP 840
+ L L+L +N I G +L+ A++ + S+ E+ + NQ+GD G + A L P
Sbjct: 1575 SQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLP 1634
Query: 841 SLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKH 900
L + L+ N IS+ GG LA +L LE L L N L D A LA+ L Q L+
Sbjct: 1635 ELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQELP--QHLRV 1692
Query: 901 LWLIQNQITAKGTAQLADALQSNTGITEICLNGN 934
L L + + G LA AL + + EI L N
Sbjct: 1693 LHLPFSHLGPGGALSLAQALDGSPHLEEISLAEN 1726
Score = 81.6 bits (200), Expect = 3e-15
Identities = 84/288 (29%), Positives = 120/288 (41%), Gaps = 53/288 (18%)
Query: 708 LDLDNNNLNDYGVRELQPCFSRLTVL---RLSVNQITDGGVKVLSEELTKYKIVTYLGLY 764
LDL + LN + L S++T L RL+ N I D G LSE L + L L
Sbjct: 1555 LDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLS 1614
Query: 765 NNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQV 824
+NQI D G +++ IL L + L N I+S GG LA ++ + + E+ + N +
Sbjct: 1615 HNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNAL 1674
Query: 825 GDE--------------------------GAKAFAEALRNHPSLTTLSLASNG------- 851
GD GA + A+AL P L +SLA N
Sbjct: 1675 GDPTALGLAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLR 1734
Query: 852 -----------------ISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKV 894
I + K L + +LE++ L+ N L DE A LA++L
Sbjct: 1735 FCMELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQ 1794
Query: 895 NQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAK 942
LK + L +NQITA G LA+ L + I I L N I + A+
Sbjct: 1795 MGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCDMAQ 1842
Score = 60.8 bits (146), Expect = 6e-09
Identities = 47/167 (28%), Positives = 76/167 (45%)
Query: 770 DVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGA 829
D + + +L L +L + +++EG +LA + + + E+ + NQ +EG
Sbjct: 1480 DASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGT 1539
Query: 830 KAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLA 889
KA AL L L L+ +++ L L Q T L+ L L +N + D L+
Sbjct: 1540 KALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLS 1599
Query: 890 EMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLI 936
E L+ +L+ L L NQI G LA L + +I L+GN I
Sbjct: 1600 EALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSI 1646
Score = 44.3 bits (103), Expect = 6e-04
Identities = 57/248 (22%), Positives = 100/248 (40%), Gaps = 33/248 (13%)
Query: 680 LKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVRELQPCFSRLTVLR---LS 736
L+L C D AL +L P +DL N L D G R + S+L + R LS
Sbjct: 847 LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLS 906
Query: 737 VNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDV---------------GARYVTKILD 781
N ++ GV + ++ + L + T + A ++ ++
Sbjct: 907 DNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAFLDSLML 966
Query: 782 ECKGLTHLKLGKNKITSEG--GKYLALAVKNSKSISEVG-----MWGNQVGDEGAKAFAE 834
+ L + ++T G K+L K +G GN +GDEGA A+
Sbjct: 967 QMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQ 1026
Query: 835 ALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKV 894
L +L +L+L+ NG+S + L R + WL + +++ ES +L+
Sbjct: 1027 LLPGLGALQSLNLSENGLSLDAVLGLVRCFS-----TLQWLFRLDIS---FESQHILLRG 1078
Query: 895 NQTLKHLW 902
++T + +W
Sbjct: 1079 DKTSRDMW 1086
Score = 30.4 bits (67), Expect = 8.2
Identities = 50/204 (24%), Positives = 82/204 (40%), Gaps = 22/204 (10%)
Query: 728 SRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLT 787
SR LRL Q+ + L L + + + L NQ+ D G R + + +
Sbjct: 842 SRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIAR 901
Query: 788 HLKLGKNKITSEGGKYLALAVKNSKSISEVGMW--------------GNQVGDEGAKAFA 833
L L N ++ G + AV +++E+ + Q G + AF
Sbjct: 902 KLDLSDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAFL 961
Query: 834 EALR-NHPSLTTLS-----LASNGISTEGGKSLARALQQNTSLEILWL--TQNELNDEVA 885
++L PS LS L G+ + + L +AL + L L L + N L DE A
Sbjct: 962 DSLMLQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGA 1021
Query: 886 ESLAEMLKVNQTLKHLWLIQNQIT 909
LA++L L+ L L +N ++
Sbjct: 1022 ARLAQLLPGLGALQSLNLSENGLS 1045
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 130 bits (328), Expect = 4e-30
Identities = 207/805 (25%), Positives = 330/805 (40%), Gaps = 84/805 (10%)
Query: 183 LLDHTTGI---LNEQGETIFILGDAGVGKSMLLQRLQSLWATGRL-DAGVKFFFHFRCRM 238
LL+H + Q + + + G AGVGK+ L+++ WA G L K+ F+ R
Sbjct: 161 LLEHLFDVDVKTGAQPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGRE 220
Query: 239 FSCFKESDRLCLQDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRV 298
+ KE L+ K + E EE+ + P LF D DEL+ +
Sbjct: 221 INQLKERS---FAQLISKDWPSTEGPIEEI----MYQPSSLLFIIDSFDELNFAFEEPEF 273
Query: 299 PDSSCP-WEPAHPL-VLLANLLSGKLLKGASKLLTAR-TGIEVPRQFLRKK--VLLRGFS 353
+ C W HP+ L+++LL +L AS L+T R T + +Q L+ V L G S
Sbjct: 274 --ALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMS 331
Query: 354 PSHLRAYARRMFPERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQ 413
Y + F ++ ++ S L++N L S+C VPL CW C + + +
Sbjct: 332 EDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVPLVCWAACTCLK------QQMEK 385
Query: 414 LPDCTMTLTDVFLLVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEK 473
D T+T L T + P + SP A LC QVA +G+
Sbjct: 386 GGDVTLTCQTTTALFTCYISSLFTPV-----DGGSPSLPNQAQLRRLC---QVAAKGIWT 437
Query: 474 SLFVFTQEEVQASGLQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDD 533
+VF +E ++ GL + D+ F+ + + Y F HL +Q FF A F +L
Sbjct: 438 MTYVFYRENLRRLGLTQSDVS-SFMDSNIIQKDAEYENCYVFTHLHVQEFFAAMFYMLKG 496
Query: 534 --RVGTQELLRFFQEWMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLF 591
G F E + +T+ P +C G ED K Q F
Sbjct: 497 SWEAGNPSCQPF--EDLKSLLQSTSYKDPHLTQMKCFL-FGLLNEDRVK-----QLERTF 548
Query: 592 LCGLLSKAKQKLLRHLVPAAALRRKRKAL-WAHLFSSL---------RGYLKSLPRVQVE 641
C + K K KLL+ + L + LF L ++ P+V +
Sbjct: 549 NCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPKVAIN 608
Query: 642 SFNQVQAMPTFIWMLRC-IYETQSQKVGQLAARGICANYL--------KLTYC--NACSA 690
++ + + + C T V + + I L ++T+C + CS
Sbjct: 609 ICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITHCWQDLCS- 667
Query: 691 DCSALSFVLHHFPKRLALDLDNNNLNDYGV----RELQPCFSRLTVLRLSVNQITDGGVK 746
VLH LDL ++NL+ + EL+ +L L L D G +
Sbjct: 668 -------VLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPD-GCQ 719
Query: 747 VLSEELTKYKIVTYLGLYNNQITDVGARYVTKIL--DECKGLTHLKLGKNKITSEGGKYL 804
+S L K + +L L + I D G + + + L ECK L L+L +T +
Sbjct: 720 DISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECK-LQTLRLESCNLTVFCCLNI 778
Query: 805 ALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPS--LTTLSLASNGISTEGGKSLAR 862
+ A+ S+S+ + + N + D+G + EALR HP L LSL S G++ G + L+
Sbjct: 779 SNALIRSQSLIFLNLSTNNLLDDGVQLLCEALR-HPKCYLERLSLESCGLTEAGCEYLSL 837
Query: 863 ALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQ-TLKHLWLIQNQITAKGTAQLADALQ 921
AL N L L L N L D + +++ L+ Q TLK L L + T+ + L+ +L
Sbjct: 838 ALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLL 897
Query: 922 SNTGITEICLNGNLIKPEEAKVYED 946
N +T + L N ++ K+ D
Sbjct: 898 HNKSLTHLDLGSNWLQDNGVKLLCD 922
Score = 74.7 bits (182), Expect = 4e-13
Identities = 75/278 (26%), Positives = 121/278 (43%), Gaps = 35/278 (12%)
Query: 680 LKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVR----------------EL 723
L+L CN C +S L + L+L NNL D GV+ L
Sbjct: 763 LRLESCNLTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSL 822
Query: 724 QPC----------------FSRLTVLRLSVNQITDGGVKVLSEELTKYK-IVTYLGLYNN 766
+ C RLT L L+ N + DGGVK++S+ L + + L L
Sbjct: 823 ESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRC 882
Query: 767 QITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKN-SKSISEVGMWGNQVG 825
T + + Y++ L K LTHL LG N + G K L ++ S ++ ++ + G +
Sbjct: 883 HFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLT 942
Query: 826 DEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQ-QNTSLEILWLTQNELNDEV 884
+ A + N+P+L +L L +N + +G K L AL+ N +++ L L L
Sbjct: 943 NACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLC 1002
Query: 885 AESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQS 922
+ L+ L N+ L + L QN + +G +L L+S
Sbjct: 1003 CQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKS 1040
Score = 71.2 bits (173), Expect = 4e-12
Identities = 68/265 (25%), Positives = 123/265 (46%), Gaps = 7/265 (2%)
Query: 692 CSALSFVLHHFPKRLALDLDNNNLNDYGVRELQPCFS----RLTVLRLSVNQITDGGVKV 747
C +S L H + LDL +++ D GV+ L +L LRL +T
Sbjct: 718 CQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLN 777
Query: 748 LSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKG-LTHLKLGKNKITSEGGKYLAL 806
+S L + + + +L L N + D G + + + L K L L L +T G +YL+L
Sbjct: 778 ISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSL 837
Query: 807 AVKNSKSISEVGMWGNQVGDEGAKAFAEALRN-HPSLTTLSLASNGISTEGGKSLARALQ 865
A+ ++K ++ + + N +GD G K ++AL++ +L +L L ++ + L+ +L
Sbjct: 838 ALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLL 897
Query: 866 QNTSLEILWLTQNELNDEVAESLAEMLK-VNQTLKHLWLIQNQITAKGTAQLADALQSNT 924
N SL L L N L D + L ++ + + L+ L L+ +T LA + +N
Sbjct: 898 HNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNP 957
Query: 925 GITEICLNGNLIKPEEAKVYEDEKR 949
+ + L N ++ + K+ D R
Sbjct: 958 NLRSLDLGNNDLQDDGVKILCDALR 982
Score = 34.3 bits (77), Expect = 0.57
Identities = 42/138 (30%), Positives = 62/138 (44%), Gaps = 8/138 (5%)
Query: 680 LKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVRELQPC--FSRLTVLRLSV 737
L+L C +A C L+ V+ + P +LDL NN+L D GV+ L + + RL +
Sbjct: 934 LELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGL 993
Query: 738 NQ--ITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKIL--DECKGLTHLKLGK 793
+T + LS L K + + L N + G + K+L +CK L L L K
Sbjct: 994 EYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCK-LQVLGLCK 1052
Query: 794 NKITSEGGKYL-ALAVKN 810
E K L A+ V N
Sbjct: 1053 EAFDEEAQKLLEAVGVSN 1070
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 127 bits (320), Expect = 4e-29
Identities = 182/739 (24%), Positives = 300/739 (40%), Gaps = 101/739 (13%)
Query: 192 NEQGETIFILGDAGVGKSMLLQRLQSLWATGRL-DAGVKFFFHFRCRMFSCFKESDRLCL 250
+E T+ G AG+GK++L +++ WA+G L + F+ CR S + L
Sbjct: 216 SEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRS---L 272
Query: 251 QDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHP 310
DL+ C P DP ++R P LF DG DEL D + W+ A
Sbjct: 273 GDLIMS--CCP--DPNPPIHKIVRKPSRILFLMDGFDELQGAFD-EHIGPLCTDWQKAER 327
Query: 311 L-VLLANLLSGKLLKGASKLLTAR-TGIEVPRQFLR--KKVLLRGFSPSHLRAYARRMFP 366
+LL++L+ KLL AS L+T R +E + L + V + GFS + + Y + F
Sbjct: 328 GDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFS 387
Query: 367 ERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTLTDVFL 426
+ A S ++ N L ++C +PL CWI+ + E L + T T V++
Sbjct: 388 DEAQARAAFSLIQENEVLFTMCFIPLVCWIV---CTGLKQQMESGKSLAQTSKTTTAVYV 444
Query: 427 LVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQAS 486
SSL+Q S L A LCSL A G+ +F + +++
Sbjct: 445 FFL---------SSLLQPRGGSQEHGLCAHLWGLCSL---AADGIWNQKILFEESDLRNH 492
Query: 487 GLQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQE 546
GLQ+ D+ FLR ++ Y F H+T Q FF A + +L++ + + +
Sbjct: 493 GLQKADVS-AFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRL 551
Query: 547 WMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQKLLRH 606
+P L+ G K + F FL GL+++ + L
Sbjct: 552 KLPSRDVTV-----------LLENYGKF------EKGYLIFVVRFLFGLVNQERTSYL-- 592
Query: 607 LVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVES-FNQVQAMPTFIWMLRCIYETQSQ 665
K L + +R L+ L ++V++ ++Q P+ + + C+YE Q +
Sbjct: 593 ----------EKKLSCKISQQIR--LELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEE 640
Query: 666 KVGQLAA---------RGICANYLKLTYC--NACSADCSALSFVLHHFPKRLALDLDNNN 714
Q A +++ ++C N + +L F LH+ PK +
Sbjct: 641 DFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGF-LHNMPKEEEEEEKEGR 699
Query: 715 LNDYGVRELQP------CFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQI 768
D V+ + P C L LS D +S L+ + + L L +N +
Sbjct: 700 HLDM-VQCVLPSSSHAACSHGLGRCGLSHECCFD-----ISLVLSSNQKLVELDLSDNAL 753
Query: 769 TDVGARYVTKILDECKGLTHLKLGKNK-------ITSEGGKYLALAVKNSKSISEVGMWG 821
D G R + C GL HL K +TS L+ + +++++ + + G
Sbjct: 754 GDFGIRLL------CVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRG 807
Query: 822 NQVGDEGAKAFAEALRNHP--SLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNE 879
N +GD+G K E L HP L L L + +++ L+ L + SL L L N+
Sbjct: 808 NTLGDKGIKLLCEGLL-HPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNND 866
Query: 880 LNDEVAESLAEMLKVNQTL 898
L D E+LK L
Sbjct: 867 LGDLGVMMFCEVLKQQSCL 885
Score = 58.5 bits (140), Expect = 3e-08
Identities = 61/257 (23%), Positives = 111/257 (43%), Gaps = 32/257 (12%)
Query: 630 GYLKSLPRVQVESFNQVQAMPTFIWMLRCIYETQSQKVGQLAARGICANYLKLTYCNACS 689
G+L ++P+ + E + + + M++C+ + S C++ L C
Sbjct: 682 GFLHNMPKEEEEEEKEGRHLD----MVQCVLPSSSHAA--------CSH--GLGRCGLSH 727
Query: 690 ADCSALSFVLHHFPKRLALDLDNNNLNDYGVR----ELQPCFSRLTVLRLSVNQITDGGV 745
C +S VL K + LDL +N L D+G+R L+ L L L + +T
Sbjct: 728 ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCC 787
Query: 746 KVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTH-------LKLGKNKITS 798
LS L+ + +T+L L N + D G + + C+GL H L+L +TS
Sbjct: 788 SALSSVLSTNQNLTHLYLRGNTLGDKGIKLL------CEGLLHPDCKLQVLELDNCNLTS 841
Query: 799 EGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPS-LTTLSLASNGISTEGG 857
L+ + +S+S+ ++ + N +GD G F E L+ L L L+ + E
Sbjct: 842 HCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 901
Query: 858 KSLARALQQNTSLEILW 874
+L ++ L +++
Sbjct: 902 SALETLQEEKPELTVVF 918
Score = 40.0 bits (92), Expect = 0.010
Identities = 26/86 (30%), Positives = 41/86 (47%), Gaps = 1/86 (1%)
Query: 836 LRNHPSLTTLSLASNGISTEGGKSLARALQQNT-SLEILWLTQNELNDEVAESLAEMLKV 894
L ++ L L L+ N + G + L L+ +L+ LWL + L +L+ +L
Sbjct: 737 LSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLST 796
Query: 895 NQTLKHLWLIQNQITAKGTAQLADAL 920
NQ L HL+L N + KG L + L
Sbjct: 797 NQNLTHLYLRGNTLGDKGIKLLCEGL 822
Score = 38.5 bits (88), Expect = 0.030
Identities = 28/94 (29%), Positives = 45/94 (47%), Gaps = 1/94 (1%)
Query: 851 GISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLK-VNQTLKHLWLIQNQIT 909
G+S E ++ L N L L L+ N L D L LK + LK LWL+ + +T
Sbjct: 724 GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLT 783
Query: 910 AKGTAQLADALQSNTGITEICLNGNLIKPEEAKV 943
+ + L+ L +N +T + L GN + + K+
Sbjct: 784 SVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKL 817
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
1 [Homo sapiens]
Length = 1009
Score = 122 bits (305), Expect = 2e-27
Identities = 182/742 (24%), Positives = 301/742 (40%), Gaps = 90/742 (12%)
Query: 197 TIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFSCFKESDRLCLQDLLFK 256
T+ + G AGVGK+ L ++ W L +++ F+ C+ S +L+ K
Sbjct: 173 TVVLHGPAGVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELS---RMGPCSFAELISK 229
Query: 257 HYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHPL-VLLA 315
+ + D + A R LF DGLDEL + + D WE P+ VLL
Sbjct: 230 DWPELQDDIPSILAQAQRI----LFVVDGLDELKVPPG-ALIQDICGDWEKKKPVPVLLG 284
Query: 316 NLLSGKLLKGASKLLTARTGIEVPRQFLRKK---VLLRGFSPSHLRAYARRMFPERALQD 372
+LL K+L A+ L+T R Q L ++ V + GF RAY R F +
Sbjct: 285 SLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAM 344
Query: 373 RLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTLTDVFLLVTEVH 432
R + +N L L S P CWI+ C +G +P C +T T +FL
Sbjct: 345 RAFELMRSNAALFQLGSAPAVCWIV--CTTLKLQMEKGEDPVPTC-LTRTGLFL---RFL 398
Query: 433 LNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQASGLQERD 492
+R + + R L +L +A +G+ + VF +E+++ G+QE D
Sbjct: 399 CSRFPQGAQL--------------RGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESD 444
Query: 493 MQL---GFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQEWMP 549
++L G + + G Y F HL+ Q F TA F L+ G R W
Sbjct: 445 LRLFLDGDILRQDRVSKG----CYSFIHLSFQQFLTALFYALEKEEGED---RDGHAW-- 495
Query: 550 PAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQKLLRHLVP 609
G + L G E+ KN D Q + FL GL ++ + K L
Sbjct: 496 DIGDVQ----------KLLSG-----EERLKNPDLIQVGH-FLFGLANEKRAKELEATFG 539
Query: 610 AAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLRCIYETQSQKVGQ 669
++ L + +L + + V +V L C+YE+Q +++
Sbjct: 540 CRMSPDIKQEL-----LQCKAHLHANKPLSVTDLKEV---------LGCLYESQEEEL-- 583
Query: 670 LAARGICANYLKLTYCNACSADCSALSFVLHHFP--KRLALDLDN----NNLNDYGVR-E 722
A+ + A + +++ +++ SF L H ++L+L + N D+ + E
Sbjct: 584 --AKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIE 641
Query: 723 LQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDE 782
+ S L L + + ++D V++L + +T+ N D R
Sbjct: 642 FESSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIG 701
Query: 783 CKGLTHLKLGKNKITSEGGKYLALA--VKNSK-SISEVGMWGNQVGDEGAKAFAEALRNH 839
K LTHL L I E L L ++N K ++ + + G+ E F L+ +
Sbjct: 702 KKTLTHLTLA-GHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKAN 760
Query: 840 PSLTTLSLASNGISTEGGKSLARAL-QQNTSLEILWLTQNELNDEVAESLAEMLKVNQTL 898
SL L L++N + EG L + + + L++L L L + + LA +L V++ L
Sbjct: 761 QSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKL 820
Query: 899 KHLWLIQNQITAKGTAQLADAL 920
HL L +N I G L + L
Sbjct: 821 THLCLAKNPIGDTGVKFLCEGL 842
Score = 68.2 bits (165), Expect = 4e-11
Identities = 64/201 (31%), Positives = 98/201 (48%), Gaps = 6/201 (2%)
Query: 733 LRLSVNQITDGGVKVLSEELTKYK-IVTYLGLYNNQITDVGARYVTKILDECKGLTHLKL 791
LRLS N + D G +L + +T+ K + L L N ++T+ + + +L K LTHL L
Sbjct: 766 LRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCL 825
Query: 792 GKNKITSEGGKYL--ALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLAS 849
KN I G K+L L+ + K + + + + G + +EAL+ SLT L L+
Sbjct: 826 AKNPIGDTGVKFLCEGLSYPDCK-LQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSI 884
Query: 850 NGISTEGGKSLARALQQ-NTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQI 908
N I+ G L +AL+ N +L+ L L L + L L NQ L+ L L QN +
Sbjct: 885 NQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHL 943
Query: 909 TAKGTAQLADALQSNTGITEI 929
G +L L+ TG +I
Sbjct: 944 WKSGIIKLFGVLRQRTGSLKI 964
Score = 52.8 bits (125), Expect = 2e-06
Identities = 63/209 (30%), Positives = 95/209 (45%), Gaps = 9/209 (4%)
Query: 679 YLKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVRELQPCFSR----LTVLR 734
YL+L A + +VL L L N L D G L +R L +L
Sbjct: 737 YLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLS 796
Query: 735 LSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILD--ECKGLTHLKLG 792
L ++T+ K L+ L K +T+L L N I D G +++ + L +CK L L L
Sbjct: 797 LENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCK-LQTLVLQ 855
Query: 793 KNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRN-HPSLTTLSLASNG 851
+ IT G +YL+ A++ + S++ + + NQ+ G +AL N + +L L L S
Sbjct: 856 QCSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCS 914
Query: 852 ISTEGGKSLARALQQNTSLEILWLTQNEL 880
+ + L AL N LE L L QN L
Sbjct: 915 LMPFYCQHLGSALLSNQKLETLDLGQNHL 943
>gi|156938336 class II transactivator [Homo sapiens]
Length = 1130
Score = 119 bits (299), Expect = 1e-26
Identities = 183/728 (25%), Positives = 273/728 (37%), Gaps = 78/728 (10%)
Query: 198 IFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFSCFKESDRLCLQDLLFKH 257
I +LG AG GKS + WA GRL F F C + + D LQDLLF
Sbjct: 416 IAVLGKAGQGKSYWAGAVSRAWACGRLPQ-YDFVFSVPCHCLN--RPGDAYGLQDLLFSL 472
Query: 258 YCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHPLVLLANL 317
P +EVF+ +L+ P L DG +EL + P EP LLA L
Sbjct: 473 GPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGLLAGL 532
Query: 318 LSGKLLKGASKLLTARTGIEVPRQFLRKKVL--LRGFSPSHLRAYARRMFPERAL---QD 372
KLL+G + LLTAR + + + L L GFS +AY R F + QD
Sbjct: 533 FQKKLLRGCTLLLTARPRGRLVQSLSKADALFELSGFSMEQAQAYVMRYFESSGMTEHQD 592
Query: 373 RLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTLTDVFLLVTEVH 432
R L+ L P L S P C + + + E + +LP TLT +++
Sbjct: 593 RALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDA-KLPS---TLTGLYV------ 642
Query: 433 LNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQASGLQERD 492
L+ R L + L L ++A + +++ ++ ++
Sbjct: 643 -------GLLGR------AALDSPPGALAELAKLAWELGRRHQSTLQEDQFPSADVRTWA 689
Query: 493 MQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRF--------- 543
M G ++ P + F LQ F A +L L + +EL ++
Sbjct: 690 MAKGLVQHPPRAA----ESELAFPSFLLQCFLGALWLALSGEIKDKELPQYLALTPRKKR 745
Query: 544 -FQEWMP--PAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAK 600
+ W+ P A PP L G A K K ++ G L +
Sbjct: 746 PYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQPGTLRARQ 805
Query: 601 QKLLRHLVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLRCIY 660
L H A + +W H+ L G L SF + P +L
Sbjct: 806 LLELLH----CAHEAEEAGIWQHVVQELPGRL---------SFLGTRLTPPDAHVLGKAL 852
Query: 661 ETQSQKVG-QLAARGICANYLK-------LTYCNACSADCSAL--SFVLHHFPKRLALDL 710
E Q L + GIC + L +T A +D AL S H K L
Sbjct: 853 EAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDTVALWESLQQHGETKLLQAAE 912
Query: 711 DNNNLNDYGVRELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITD 770
+ + + + L+ + +L Q T + + EL + + L ++
Sbjct: 913 EKFTIEPFKAKSLKDVED---LGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPVSG 969
Query: 771 VGA-RYVTKILDECKGLTHL---KLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGD 826
A + +IL L HL L +NKI EG L+ KS+ + + N + D
Sbjct: 970 PQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITD 1029
Query: 827 EGAKAFAEALRN-HPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVA 885
GA AEAL + SL LSL +N I G +SLAR L SL ++ + N+ A
Sbjct: 1030 LGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGA 1089
Query: 886 ESLAEMLK 893
+ LA L+
Sbjct: 1090 QQLAASLR 1097
Score = 63.2 bits (152), Expect = 1e-09
Identities = 44/130 (33%), Positives = 63/130 (48%), Gaps = 7/130 (5%)
Query: 698 VLHHFPKRLALDLD---NNNLNDYGVRELQPCFSRLT---VLRLSVNQITDGGVKVLSEE 751
+L F LDLD N + D GV +L F +L L LS N ITD G L+E
Sbjct: 979 ILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEA 1038
Query: 752 LTKYKI-VTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKN 810
L + L LYNN I DVGA + ++L + L + + NK T+ G + LA +++
Sbjct: 1039 LPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRR 1098
Query: 811 SKSISEVGMW 820
+ + MW
Sbjct: 1099 CPHVETLAMW 1108
Score = 34.7 bits (78), Expect = 0.44
Identities = 35/139 (25%), Positives = 61/139 (43%), Gaps = 8/139 (5%)
Query: 792 GKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNH-PSLTTLSLASN 850
G+ K+ + + +KS+ +V G V + ++ +E P++ L
Sbjct: 903 GETKLLQAAEEKFTIEPFKAKSLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKLEF 962
Query: 851 GISTEGGKS----LARALQQNTSLEIL---WLTQNELNDEVAESLAEMLKVNQTLKHLWL 903
+ G L R L +SL+ L L++N++ DE L+ ++L+ L L
Sbjct: 963 ALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNL 1022
Query: 904 IQNQITAKGTAQLADALQS 922
QN IT G +LA+AL S
Sbjct: 1023 SQNNITDLGAYKLAEALPS 1041
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 113 bits (282), Expect = 1e-24
Identities = 193/804 (24%), Positives = 321/804 (39%), Gaps = 133/804 (16%)
Query: 193 EQGETIFILGDAGVGKSMLLQRLQSLWATGRLDAG-VKFFFHFRCRMFSCFKESDRLCLQ 251
+Q T+ I G G+GK+ LL +L W+ ++ + F+F CR +E L
Sbjct: 146 KQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCREL---RELPPTSLA 202
Query: 252 DLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCP---WEPA 308
DL+ + + DP ++ P LF D +EL L+ PDS E
Sbjct: 203 DLISREW----PDPAAPITEIVSQPERLLFVIDSFEELQGGLN---EPDSDLCGDLMEKR 255
Query: 309 HPLVLLANLLSGKLLKGASKLLTARTGIEVPRQFLRKKVLL------RGFSPSHLRAYAR 362
VLL++LL K+L AS L+ + V + LR +V + RGF+ S Y
Sbjct: 256 PVQVLLSSLLRKKMLPEASLLIAIKP---VCPKELRDQVTISEIYQPRGFNESDRLVYFC 312
Query: 363 RMF--PERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMT 420
F P+RA++ + + + L S+C +PL CWI+ C + +G D +T
Sbjct: 313 CFFKDPKRAME--AFNLVRESEQLFSICQIPLLCWIL--CTSLKQEMQKGK----DLALT 364
Query: 421 LTDVFLLVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQ 480
+ + N P P LCSL A GM F F +
Sbjct: 365 CQSTTSVYSSFVFNLFTP-----EGAEGPTPQTQHQLKALCSL---AAEGMWTDTFEFCE 416
Query: 481 EEVQASGLQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQEL 540
++++ +G+ + D+ L L G + SY F H+ +Q F A F +L +
Sbjct: 417 DDLRRNGVVDADIP-ALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKSHLD---- 471
Query: 541 LRFFQEWMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAK 600
P +C+Q A + + + H+ F FL GLL+K +
Sbjct: 472 -------------------HPHPAVRCVQELLVANFEKAR-RAHWIFLGCFLTGLLNKKE 511
Query: 601 QKLLRHLVPAAALRRKRKALWAHLFSSLRGYLKSL-----PRVQVESFNQVQAMPTFIWM 655
Q+ L L + + LKSL P+ QV+S + +
Sbjct: 512 QEKLDAFFGF--------QLSQEIKQQIHQCLKSLGERGNPQGQVDS----------LAI 553
Query: 656 LRCIYETQSQKVGQLAARGIC-ANY-----LKLTYCNACSADCSALSFVLHHFPKRLALD 709
C++E Q + A + AN+ + L C CS+L + +
Sbjct: 554 FYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLRKLCFSVQNVFKKE 613
Query: 710 LDNNNLNDYG----------------VRELQPCFSRLT-----------------VLRLS 736
++++ +DY +RELQ S L+ + +L
Sbjct: 614 DEHSSTSDYSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLG 673
Query: 737 VNQITDGGVKVLSEELTKYK-IVTYLGLYNNQITDVGARYVTKILDECKG-LTHLKLGKN 794
+N ++ G VL E+ Y+ + YL +++ R + L+ G + L L
Sbjct: 674 INNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNC 733
Query: 795 KITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPS-LTTLSLASNGIS 853
++ + LA + N+K ++ + + NQ+ D G EAL + + L L LA +S
Sbjct: 734 HLSPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLS 792
Query: 854 TEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLK-VNQTLKHLWLIQNQITAKG 912
+ + ++ L +N S+ L L+ N L DE ++L E LK + L L L++ ITA G
Sbjct: 793 EQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAG 852
Query: 913 TAQLADALQSNTGITEICLNGNLI 936
LA AL SN + + + N I
Sbjct: 853 CEDLASALISNQNLKILQIGCNEI 876
Score = 56.6 bits (135), Expect = 1e-07
Identities = 57/197 (28%), Positives = 96/197 (48%), Gaps = 10/197 (5%)
Query: 746 KVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKG---LTHLKLGKNKITSEGGK 802
+VL+ LT K +TYL + NQ+ D G + + L C L +L L ++ + +
Sbjct: 741 EVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEAL--CSPDTVLVYLMLAFCHLSEQCCE 797
Query: 803 YLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPS--LTTLSLASNGISTEGGKSL 860
Y++ + +KS+ + + N + DEG K EAL+ HP L +L L I+ G + L
Sbjct: 798 YISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALK-HPDCCLDSLCLVKCFITAAGCEDL 856
Query: 861 ARALQQNTSLEILWLTQNELNDEVAESLAEML-KVNQTLKHLWLIQNQITAKGTAQLADA 919
A AL N +L+IL + NE+ D + L L + L+ L L + +T+ LA
Sbjct: 857 ASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASV 916
Query: 920 LQSNTGITEICLNGNLI 936
L + + ++ L N +
Sbjct: 917 LTCSKTLQQLNLTLNTL 933
Score = 51.2 bits (121), Expect = 4e-06
Identities = 58/207 (28%), Positives = 86/207 (41%), Gaps = 20/207 (9%)
Query: 679 YLKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVRELQPCFSR----LTVLR 734
YL L +C+ C +S +L LDL N L D G++ L L L
Sbjct: 783 YLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLC 842
Query: 735 LSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTH------ 788
L IT G + L+ L + + L + N+I DVG + + C+ LTH
Sbjct: 843 LVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLL------CRALTHTDCRLE 896
Query: 789 -LKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHP--SLTTL 845
L L + +TS K LA + SK++ ++ + N + G EALR HP +L L
Sbjct: 897 ILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALR-HPECALQVL 955
Query: 846 SLASNGISTEGGKSLARALQQNTSLEI 872
L E L ++N +L I
Sbjct: 956 GLRKTDFDEETQALLTAEEERNPNLTI 982
Score = 30.8 bits (68), Expect = 6.3
Identities = 32/117 (27%), Positives = 45/117 (38%), Gaps = 10/117 (8%)
Query: 676 CANYLKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGV----RELQPCFSRLT 731
C + L L C +A C L+ L L + N + D GV R L RL
Sbjct: 837 CLDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLE 896
Query: 732 VLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTH 788
+L L +T K L+ LT K + L L N + G ++ C+ L H
Sbjct: 897 ILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTG------VVVLCEALRH 947
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 112 bits (281), Expect = 1e-24
Identities = 179/725 (24%), Positives = 287/725 (39%), Gaps = 118/725 (16%)
Query: 189 GILNEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKF--FFHFRCRMFSCFKESD 246
G+ ++ + + G AG+GKS L ++++ W G+L G +F F+F CR + +S
Sbjct: 321 GLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQL-YGDRFQHVFYFSCRELA---QSK 376
Query: 247 RLCLQDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSC-PW 305
+ L +L+ K P + L R P LF DG+DE L C W
Sbjct: 377 VVSLAELIGKD---GTATPAPIRQILSR-PERLLFILDGVDE--PGWVLQEPSSELCLHW 430
Query: 306 EPAHPL-VLLANLLSGKLLKGASKLLTARTGIE---VPRQFLRKKVLLRGFSPSHLRAYA 361
P LL +LL +L AS L+TART +P + V + GFS S + Y
Sbjct: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
Query: 362 RRMFPERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTL 421
R F + R +++N L +LC VP W+ C E T TL
Sbjct: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
Query: 422 TDVFLLVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQE 481
+L + QP R+ LCSL A G+ + +F+ +
Sbjct: 551 CLHYL----AQALQAQPLGPQLRD--------------LCSL---AAEGIWQKKTLFSPD 589
Query: 482 EVQASGLQ----ERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGT 537
+++ GL +++G L+ P SY F HL Q FF A VL+D G
Sbjct: 590 DLRKHGLDGAIISTFLKMGILQEHP------IPLSYSFIHLCFQEFFAAMSYVLEDEKGR 643
Query: 538 QELLRFFQEWMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLS 597
+ + T Y L G+ R FL GLLS
Sbjct: 644 GKHSNCIIDL-----EKTLEAY----GIHGLFGASTTR---------------FLLGLLS 679
Query: 598 KAKQKLLRHLVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLR 657
++ + ++ + + W + SL Q+ P + L
Sbjct: 680 DEGEREMENIFHCRLSQGRNLMQW----------VPSL---------QLLLQPHSLESLH 720
Query: 658 CIYETQ-----SQKVGQLAARGICANY-LKLTYCNACSADCSALSFVLHHFPKRLALDLD 711
C+YET+ +Q + G+C ++L C C + F H K+L L
Sbjct: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFC------IKFSRH--VKKLQL--- 769
Query: 712 NNNLNDYGVRELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDV 771
R+ + +S V+ +TD ++L L + + L L N ++
Sbjct: 770 ------IEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHS 823
Query: 772 GARYVTKILDECKGLTH-LKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAK 830
+ + K L + L L+L +T+E K LA ++ +++++E+ + N + D GAK
Sbjct: 824 AVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAK 883
Query: 831 AFAEALRNHPS--LTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESL 888
+ LR PS L L L S G++++ + LA L + SL+ L L QN L+D L
Sbjct: 884 HLCQRLR-QPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLL 942
Query: 889 AEMLK 893
E L+
Sbjct: 943 CEGLR 947
Score = 31.6 bits (70), Expect = 3.7
Identities = 28/105 (26%), Positives = 46/105 (43%), Gaps = 4/105 (3%)
Query: 13 PSESHPHIQLLKSNRELLVTHIRNTQCLVDNLLKNDYFSAEDAEIVCACPTQPDKVRKIL 72
P ++ + + RE L+ + + + ++D L S E E V A T+P ++RK+
Sbjct: 1328 PLDAPQLLHFVDQYREQLIARVTSVEVVLDKL-HGQVLSQEQYERVLAENTRPSQMRKLF 1386
Query: 73 DLVQSKGEEVSEFFLYLLQQLADAYVDLRPWLLEIGFSPSLLTQS 117
L QS + + L Q L + + L L E G LL S
Sbjct: 1387 SLSQSWDRKCKD---GLYQALKETHPHLIMELWEKGSKKGLLPLS 1428
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 112 bits (281), Expect = 1e-24
Identities = 179/725 (24%), Positives = 287/725 (39%), Gaps = 118/725 (16%)
Query: 189 GILNEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKF--FFHFRCRMFSCFKESD 246
G+ ++ + + G AG+GKS L ++++ W G+L G +F F+F CR + +S
Sbjct: 321 GLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQL-YGDRFQHVFYFSCRELA---QSK 376
Query: 247 RLCLQDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSC-PW 305
+ L +L+ K P + L R P LF DG+DE L C W
Sbjct: 377 VVSLAELIGKD---GTATPAPIRQILSR-PERLLFILDGVDE--PGWVLQEPSSELCLHW 430
Query: 306 EPAHPL-VLLANLLSGKLLKGASKLLTARTGIE---VPRQFLRKKVLLRGFSPSHLRAYA 361
P LL +LL +L AS L+TART +P + V + GFS S + Y
Sbjct: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
Query: 362 RRMFPERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTL 421
R F + R +++N L +LC VP W+ C E T TL
Sbjct: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
Query: 422 TDVFLLVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQE 481
+L + QP R+ LCSL A G+ + +F+ +
Sbjct: 551 CLHYL----AQALQAQPLGPQLRD--------------LCSL---AAEGIWQKKTLFSPD 589
Query: 482 EVQASGLQ----ERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGT 537
+++ GL +++G L+ P SY F HL Q FF A VL+D G
Sbjct: 590 DLRKHGLDGAIISTFLKMGILQEHP------IPLSYSFIHLCFQEFFAAMSYVLEDEKGR 643
Query: 538 QELLRFFQEWMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLS 597
+ + T Y L G+ R FL GLLS
Sbjct: 644 GKHSNCIIDL-----EKTLEAY----GIHGLFGASTTR---------------FLLGLLS 679
Query: 598 KAKQKLLRHLVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLR 657
++ + ++ + + W + SL Q+ P + L
Sbjct: 680 DEGEREMENIFHCRLSQGRNLMQW----------VPSL---------QLLLQPHSLESLH 720
Query: 658 CIYETQ-----SQKVGQLAARGICANY-LKLTYCNACSADCSALSFVLHHFPKRLALDLD 711
C+YET+ +Q + G+C ++L C C + F H K+L L
Sbjct: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFC------IKFSRH--VKKLQL--- 769
Query: 712 NNNLNDYGVRELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDV 771
R+ + +S V+ +TD ++L L + + L L N ++
Sbjct: 770 ------IEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHS 823
Query: 772 GARYVTKILDECKGLTH-LKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAK 830
+ + K L + L L+L +T+E K LA ++ +++++E+ + N + D GAK
Sbjct: 824 AVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAK 883
Query: 831 AFAEALRNHPS--LTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESL 888
+ LR PS L L L S G++++ + LA L + SL+ L L QN L+D L
Sbjct: 884 HLCQRLR-QPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLL 942
Query: 889 AEMLK 893
E L+
Sbjct: 943 CEGLR 947
Score = 31.6 bits (70), Expect = 3.7
Identities = 28/105 (26%), Positives = 46/105 (43%), Gaps = 4/105 (3%)
Query: 13 PSESHPHIQLLKSNRELLVTHIRNTQCLVDNLLKNDYFSAEDAEIVCACPTQPDKVRKIL 72
P ++ + + RE L+ + + + ++D L S E E V A T+P ++RK+
Sbjct: 1298 PLDAPQLLHFVDQYREQLIARVTSVEVVLDKL-HGQVLSQEQYERVLAENTRPSQMRKLF 1356
Query: 73 DLVQSKGEEVSEFFLYLLQQLADAYVDLRPWLLEIGFSPSLLTQS 117
L QS + + L Q L + + L L E G LL S
Sbjct: 1357 SLSQSWDRKCKD---GLYQALKETHPHLIMELWEKGSKKGLLPLS 1398
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 112 bits (281), Expect = 1e-24
Identities = 179/725 (24%), Positives = 287/725 (39%), Gaps = 118/725 (16%)
Query: 189 GILNEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKF--FFHFRCRMFSCFKESD 246
G+ ++ + + G AG+GKS L ++++ W G+L G +F F+F CR + +S
Sbjct: 321 GLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQL-YGDRFQHVFYFSCRELA---QSK 376
Query: 247 RLCLQDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSC-PW 305
+ L +L+ K P + L R P LF DG+DE L C W
Sbjct: 377 VVSLAELIGKD---GTATPAPIRQILSR-PERLLFILDGVDE--PGWVLQEPSSELCLHW 430
Query: 306 EPAHPL-VLLANLLSGKLLKGASKLLTARTGIE---VPRQFLRKKVLLRGFSPSHLRAYA 361
P LL +LL +L AS L+TART +P + V + GFS S + Y
Sbjct: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
Query: 362 RRMFPERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTL 421
R F + R +++N L +LC VP W+ C E T TL
Sbjct: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
Query: 422 TDVFLLVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQE 481
+L + QP R+ LCSL A G+ + +F+ +
Sbjct: 551 CLHYL----AQALQAQPLGPQLRD--------------LCSL---AAEGIWQKKTLFSPD 589
Query: 482 EVQASGLQ----ERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGT 537
+++ GL +++G L+ P SY F HL Q FF A VL+D G
Sbjct: 590 DLRKHGLDGAIISTFLKMGILQEHP------IPLSYSFIHLCFQEFFAAMSYVLEDEKGR 643
Query: 538 QELLRFFQEWMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLS 597
+ + T Y L G+ R FL GLLS
Sbjct: 644 GKHSNCIIDL-----EKTLEAY----GIHGLFGASTTR---------------FLLGLLS 679
Query: 598 KAKQKLLRHLVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLR 657
++ + ++ + + W + SL Q+ P + L
Sbjct: 680 DEGEREMENIFHCRLSQGRNLMQW----------VPSL---------QLLLQPHSLESLH 720
Query: 658 CIYETQ-----SQKVGQLAARGICANY-LKLTYCNACSADCSALSFVLHHFPKRLALDLD 711
C+YET+ +Q + G+C ++L C C + F H K+L L
Sbjct: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFC------IKFSRH--VKKLQL--- 769
Query: 712 NNNLNDYGVRELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDV 771
R+ + +S V+ +TD ++L L + + L L N ++
Sbjct: 770 ------IEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHS 823
Query: 772 GARYVTKILDECKGLTH-LKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAK 830
+ + K L + L L+L +T+E K LA ++ +++++E+ + N + D GAK
Sbjct: 824 AVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAK 883
Query: 831 AFAEALRNHPS--LTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESL 888
+ LR PS L L L S G++++ + LA L + SL+ L L QN L+D L
Sbjct: 884 HLCQRLR-QPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLL 942
Query: 889 AEMLK 893
E L+
Sbjct: 943 CEGLR 947
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 112 bits (281), Expect = 1e-24
Identities = 179/725 (24%), Positives = 287/725 (39%), Gaps = 118/725 (16%)
Query: 189 GILNEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKF--FFHFRCRMFSCFKESD 246
G+ ++ + + G AG+GKS L ++++ W G+L G +F F+F CR + +S
Sbjct: 321 GLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQL-YGDRFQHVFYFSCRELA---QSK 376
Query: 247 RLCLQDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSC-PW 305
+ L +L+ K P + L R P LF DG+DE L C W
Sbjct: 377 VVSLAELIGKD---GTATPAPIRQILSR-PERLLFILDGVDE--PGWVLQEPSSELCLHW 430
Query: 306 EPAHPL-VLLANLLSGKLLKGASKLLTARTGIE---VPRQFLRKKVLLRGFSPSHLRAYA 361
P LL +LL +L AS L+TART +P + V + GFS S + Y
Sbjct: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
Query: 362 RRMFPERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTL 421
R F + R +++N L +LC VP W+ C E T TL
Sbjct: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
Query: 422 TDVFLLVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQE 481
+L + QP R+ LCSL A G+ + +F+ +
Sbjct: 551 CLHYL----AQALQAQPLGPQLRD--------------LCSL---AAEGIWQKKTLFSPD 589
Query: 482 EVQASGLQ----ERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGT 537
+++ GL +++G L+ P SY F HL Q FF A VL+D G
Sbjct: 590 DLRKHGLDGAIISTFLKMGILQEHP------IPLSYSFIHLCFQEFFAAMSYVLEDEKGR 643
Query: 538 QELLRFFQEWMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLS 597
+ + T Y L G+ R FL GLLS
Sbjct: 644 GKHSNCIIDL-----EKTLEAY----GIHGLFGASTTR---------------FLLGLLS 679
Query: 598 KAKQKLLRHLVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLR 657
++ + ++ + + W + SL Q+ P + L
Sbjct: 680 DEGEREMENIFHCRLSQGRNLMQW----------VPSL---------QLLLQPHSLESLH 720
Query: 658 CIYETQ-----SQKVGQLAARGICANY-LKLTYCNACSADCSALSFVLHHFPKRLALDLD 711
C+YET+ +Q + G+C ++L C C + F H K+L L
Sbjct: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFC------IKFSRH--VKKLQL--- 769
Query: 712 NNNLNDYGVRELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDV 771
R+ + +S V+ +TD ++L L + + L L N ++
Sbjct: 770 ------IEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHS 823
Query: 772 GARYVTKILDECKGLTH-LKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAK 830
+ + K L + L L+L +T+E K LA ++ +++++E+ + N + D GAK
Sbjct: 824 AVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAK 883
Query: 831 AFAEALRNHPS--LTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESL 888
+ LR PS L L L S G++++ + LA L + SL+ L L QN L+D L
Sbjct: 884 HLCQRLR-QPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLL 942
Query: 889 AEMLK 893
E L+
Sbjct: 943 CEGLR 947
Score = 31.6 bits (70), Expect = 3.7
Identities = 28/105 (26%), Positives = 46/105 (43%), Gaps = 4/105 (3%)
Query: 13 PSESHPHIQLLKSNRELLVTHIRNTQCLVDNLLKNDYFSAEDAEIVCACPTQPDKVRKIL 72
P ++ + + RE L+ + + + ++D L S E E V A T+P ++RK+
Sbjct: 1342 PLDAPQLLHFVDQYREQLIARVTSVEVVLDKL-HGQVLSQEQYERVLAENTRPSQMRKLF 1400
Query: 73 DLVQSKGEEVSEFFLYLLQQLADAYVDLRPWLLEIGFSPSLLTQS 117
L QS + + L Q L + + L L E G LL S
Sbjct: 1401 SLSQSWDRKCKD---GLYQALKETHPHLIMELWEKGSKKGLLPLS 1442
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 112 bits (281), Expect = 1e-24
Identities = 179/725 (24%), Positives = 287/725 (39%), Gaps = 118/725 (16%)
Query: 189 GILNEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKF--FFHFRCRMFSCFKESD 246
G+ ++ + + G AG+GKS L ++++ W G+L G +F F+F CR + +S
Sbjct: 321 GLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQL-YGDRFQHVFYFSCRELA---QSK 376
Query: 247 RLCLQDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSC-PW 305
+ L +L+ K P + L R P LF DG+DE L C W
Sbjct: 377 VVSLAELIGKD---GTATPAPIRQILSR-PERLLFILDGVDE--PGWVLQEPSSELCLHW 430
Query: 306 EPAHPL-VLLANLLSGKLLKGASKLLTARTGIE---VPRQFLRKKVLLRGFSPSHLRAYA 361
P LL +LL +L AS L+TART +P + V + GFS S + Y
Sbjct: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490
Query: 362 RRMFPERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTL 421
R F + R +++N L +LC VP W+ C E T TL
Sbjct: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550
Query: 422 TDVFLLVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQE 481
+L + QP R+ LCSL A G+ + +F+ +
Sbjct: 551 CLHYL----AQALQAQPLGPQLRD--------------LCSL---AAEGIWQKKTLFSPD 589
Query: 482 EVQASGLQ----ERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGT 537
+++ GL +++G L+ P SY F HL Q FF A VL+D G
Sbjct: 590 DLRKHGLDGAIISTFLKMGILQEHP------IPLSYSFIHLCFQEFFAAMSYVLEDEKGR 643
Query: 538 QELLRFFQEWMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLS 597
+ + T Y L G+ R FL GLLS
Sbjct: 644 GKHSNCIIDL-----EKTLEAY----GIHGLFGASTTR---------------FLLGLLS 679
Query: 598 KAKQKLLRHLVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLR 657
++ + ++ + + W + SL Q+ P + L
Sbjct: 680 DEGEREMENIFHCRLSQGRNLMQW----------VPSL---------QLLLQPHSLESLH 720
Query: 658 CIYETQ-----SQKVGQLAARGICANY-LKLTYCNACSADCSALSFVLHHFPKRLALDLD 711
C+YET+ +Q + G+C ++L C C + F H K+L L
Sbjct: 721 CLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFC------IKFSRH--VKKLQL--- 769
Query: 712 NNNLNDYGVRELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDV 771
R+ + +S V+ +TD ++L L + + L L N ++
Sbjct: 770 ------IEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHS 823
Query: 772 GARYVTKILDECKGLTH-LKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAK 830
+ + K L + L L+L +T+E K LA ++ +++++E+ + N + D GAK
Sbjct: 824 AVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAK 883
Query: 831 AFAEALRNHPS--LTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESL 888
+ LR PS L L L S G++++ + LA L + SL+ L L QN L+D L
Sbjct: 884 HLCQRLR-QPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLL 942
Query: 889 AEMLK 893
E L+
Sbjct: 943 CEGLR 947
Score = 31.6 bits (70), Expect = 3.7
Identities = 28/105 (26%), Positives = 46/105 (43%), Gaps = 4/105 (3%)
Query: 13 PSESHPHIQLLKSNRELLVTHIRNTQCLVDNLLKNDYFSAEDAEIVCACPTQPDKVRKIL 72
P ++ + + RE L+ + + + ++D L S E E V A T+P ++RK+
Sbjct: 1372 PLDAPQLLHFVDQYREQLIARVTSVEVVLDKL-HGQVLSQEQYERVLAENTRPSQMRKLF 1430
Query: 73 DLVQSKGEEVSEFFLYLLQQLADAYVDLRPWLLEIGFSPSLLTQS 117
L QS + + L Q L + + L L E G LL S
Sbjct: 1431 SLSQSWDRKCKD---GLYQALKETHPHLIMELWEKGSKKGLLPLS 1472
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7
isoform 3 [Homo sapiens]
Length = 1037
Score = 112 bits (280), Expect = 2e-24
Identities = 187/770 (24%), Positives = 302/770 (39%), Gaps = 118/770 (15%)
Query: 197 TIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFSCFKESDRLCLQDLLFK 256
T+ + G AGVGK+ L ++ W L +++ F+ C+ S +L+ K
Sbjct: 173 TVVLHGPAGVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELS---RMGPCSFAELISK 229
Query: 257 HYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHPL-VLLA 315
+ + D + A R LF DGLDEL + + D WE P+ VLL
Sbjct: 230 DWPELQDDIPSILAQAQRI----LFVVDGLDELKVPPG-ALIQDICGDWEKKKPVPVLLG 284
Query: 316 NLLSGKLLKGASKLLTARTGIEVPRQFLRKK---VLLRGFSPSHLRAYARRMFPERALQD 372
+LL K+L A+ L+T R Q L ++ V + GF RAY R F +
Sbjct: 285 SLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAM 344
Query: 373 RLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTLTDVFLLVTEVH 432
R + +N L L S P CWI+ C +G +P C +T T +FL
Sbjct: 345 RAFELMRSNAALFQLGSAPAVCWIV--CTTLKLQMEKGEDPVPTC-LTRTGLFL---RFL 398
Query: 433 LNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQASGLQERD 492
+R + + R L +L +A +G+ + VF +E+++ G+QE D
Sbjct: 399 CSRFPQGAQL--------------RGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESD 444
Query: 493 MQL---GFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQEWMP 549
++L G + + G Y F HL+ Q F TA F L+ G R W
Sbjct: 445 LRLFLDGDILRQDRVSKG----CYSFIHLSFQQFLTALFYALEKEEGED---RDGHAW-- 495
Query: 550 PAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQKLLRHLVP 609
G + L G E+ KN D Q + FL GL ++ + K L
Sbjct: 496 DIGDVQ----------KLLSG-----EERLKNPDLIQVGH-FLFGLANEKRAKELEATFG 539
Query: 610 AAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLRCIYETQSQKVGQ 669
++ L + +L + + V +V L C+YE+Q +++
Sbjct: 540 CRMSPDIKQEL-----LQCKAHLHANKPLSVTDLKEV---------LGCLYESQEEEL-- 583
Query: 670 LAARGICANYLKLTYCNACSADCSALSFVLHHFP--KRLALDLDNN-NLNDYGVRELQPC 726
A+ + A + +++ +++ SF L H ++L+L + L +Y EL
Sbjct: 584 --AKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIE 641
Query: 727 FSRLTVLR------------------------------LSVNQ--ITDGGVKVLSEELTK 754
F R T L L V Q ++D V++L + +T+
Sbjct: 642 FERCTYLTIPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTR 701
Query: 755 YKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALA--VKNSK 812
N D R K LTHL L I E L L ++N K
Sbjct: 702 STCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLA-GHIEWERTMMLMLCDLLRNHK 760
Query: 813 -SISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARAL-QQNTSL 870
++ + + G+ E F L+ + SL L L++N + EG L + + + L
Sbjct: 761 CNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFL 820
Query: 871 EILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADAL 920
++L L L + + LA +L V++ L HL L +N I G L + L
Sbjct: 821 QMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGL 870
Score = 68.2 bits (165), Expect = 4e-11
Identities = 64/201 (31%), Positives = 98/201 (48%), Gaps = 6/201 (2%)
Query: 733 LRLSVNQITDGGVKVLSEELTKYK-IVTYLGLYNNQITDVGARYVTKILDECKGLTHLKL 791
LRLS N + D G +L + +T+ K + L L N ++T+ + + +L K LTHL L
Sbjct: 794 LRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCL 853
Query: 792 GKNKITSEGGKYL--ALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLAS 849
KN I G K+L L+ + K + + + + G + +EAL+ SLT L L+
Sbjct: 854 AKNPIGDTGVKFLCEGLSYPDCK-LQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSI 912
Query: 850 NGISTEGGKSLARALQQ-NTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQI 908
N I+ G L +AL+ N +L+ L L L + L L NQ L+ L L QN +
Sbjct: 913 NQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHL 971
Query: 909 TAKGTAQLADALQSNTGITEI 929
G +L L+ TG +I
Sbjct: 972 WKSGIIKLFGVLRQRTGSLKI 992
Score = 52.8 bits (125), Expect = 2e-06
Identities = 63/209 (30%), Positives = 95/209 (45%), Gaps = 9/209 (4%)
Query: 679 YLKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVRELQPCFSR----LTVLR 734
YL+L A + +VL L L N L D G L +R L +L
Sbjct: 765 YLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLS 824
Query: 735 LSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILD--ECKGLTHLKLG 792
L ++T+ K L+ L K +T+L L N I D G +++ + L +CK L L L
Sbjct: 825 LENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCK-LQTLVLQ 883
Query: 793 KNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRN-HPSLTTLSLASNG 851
+ IT G +YL+ A++ + S++ + + NQ+ G +AL N + +L L L S
Sbjct: 884 QCSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCS 942
Query: 852 ISTEGGKSLARALQQNTSLEILWLTQNEL 880
+ + L AL N LE L L QN L
Sbjct: 943 LMPFYCQHLGSALLSNQKLETLDLGQNHL 971
Score = 46.2 bits (108), Expect = 1e-04
Identities = 45/153 (29%), Positives = 71/153 (46%), Gaps = 2/153 (1%)
Query: 786 LTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEAL-RNHPSLTT 844
L +L+LG + T E +K ++S+ + + N + DEGA + + R L
Sbjct: 763 LQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQM 822
Query: 845 LSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKV-NQTLKHLWL 903
LSL + ++ K LA L + L L L +N + D + L E L + L+ L L
Sbjct: 823 LSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVL 882
Query: 904 IQNQITAKGTAQLADALQSNTGITEICLNGNLI 936
Q IT G L++ALQ +T + L+ N I
Sbjct: 883 QQCSITKLGCRYLSEALQEACSLTNLDLSINQI 915
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 112 bits (280), Expect = 2e-24
Identities = 187/770 (24%), Positives = 302/770 (39%), Gaps = 118/770 (15%)
Query: 197 TIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFSCFKESDRLCLQDLLFK 256
T+ + G AGVGK+ L ++ W L +++ F+ C+ S +L+ K
Sbjct: 173 TVVLHGPAGVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELS---RMGPCSFAELISK 229
Query: 257 HYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHPL-VLLA 315
+ + D + A R LF DGLDEL + + D WE P+ VLL
Sbjct: 230 DWPELQDDIPSILAQAQRI----LFVVDGLDELKVPPG-ALIQDICGDWEKKKPVPVLLG 284
Query: 316 NLLSGKLLKGASKLLTARTGIEVPRQFLRKK---VLLRGFSPSHLRAYARRMFPERALQD 372
+LL K+L A+ L+T R Q L ++ V + GF RAY R F +
Sbjct: 285 SLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAM 344
Query: 373 RLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTLTDVFLLVTEVH 432
R + +N L L S P CWI+ C +G +P C +T T +FL
Sbjct: 345 RAFELMRSNAALFQLGSAPAVCWIV--CTTLKLQMEKGEDPVPTC-LTRTGLFL---RFL 398
Query: 433 LNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQASGLQERD 492
+R + + R L +L +A +G+ + VF +E+++ G+QE D
Sbjct: 399 CSRFPQGAQL--------------RGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESD 444
Query: 493 MQL---GFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQEWMP 549
++L G + + G Y F HL+ Q F TA F L+ G R W
Sbjct: 445 LRLFLDGDILRQDRVSKG----CYSFIHLSFQQFLTALFYALEKEEGED---RDGHAW-- 495
Query: 550 PAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQKLLRHLVP 609
G + L G E+ KN D Q + FL GL ++ + K L
Sbjct: 496 DIGDVQ----------KLLSG-----EERLKNPDLIQVGH-FLFGLANEKRAKELEATFG 539
Query: 610 AAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLRCIYETQSQKVGQ 669
++ L + +L + + V +V L C+YE+Q +++
Sbjct: 540 CRMSPDIKQEL-----LQCKAHLHANKPLSVTDLKEV---------LGCLYESQEEEL-- 583
Query: 670 LAARGICANYLKLTYCNACSADCSALSFVLHHFP--KRLALDLDNN-NLNDYGVRELQPC 726
A+ + A + +++ +++ SF L H ++L+L + L +Y EL
Sbjct: 584 --AKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIE 641
Query: 727 FSRLTVLR------------------------------LSVNQ--ITDGGVKVLSEELTK 754
F R T L L V Q ++D V++L + +T+
Sbjct: 642 FERCTYLTIPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTR 701
Query: 755 YKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALA--VKNSK 812
N D R K LTHL L I E L L ++N K
Sbjct: 702 STCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLA-GHIEWERTMMLMLCDLLRNHK 760
Query: 813 -SISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARAL-QQNTSL 870
++ + + G+ E F L+ + SL L L++N + EG L + + + L
Sbjct: 761 CNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFL 820
Query: 871 EILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADAL 920
++L L L + + LA +L V++ L HL L +N I G L + L
Sbjct: 821 QMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGL 870
Score = 60.1 bits (144), Expect = 1e-08
Identities = 55/170 (32%), Positives = 87/170 (51%), Gaps = 6/170 (3%)
Query: 733 LRLSVNQITDGGVKVLSEELTKYK-IVTYLGLYNNQITDVGARYVTKILDECKGLTHLKL 791
LRLS N + D G +L + +T+ K + L L N ++T+ + + +L K LTHL L
Sbjct: 794 LRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCL 853
Query: 792 GKNKITSEGGKYL--ALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLAS 849
KN I G K+L L+ + K + + + + G + +EAL+ SLT L L+
Sbjct: 854 AKNPIGDTGVKFLCEGLSYPDCK-LQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSI 912
Query: 850 NGISTEGGKSLARALQQ-NTSLEILWLTQNELNDEVAESLAEMLKVNQTL 898
N I+ G L +AL+ N +L+ L L E N E+ + L E+ + N L
Sbjct: 913 NQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKL 961
Score = 47.0 bits (110), Expect = 8e-05
Identities = 57/201 (28%), Positives = 91/201 (45%), Gaps = 9/201 (4%)
Query: 679 YLKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVRELQPCFSR----LTVLR 734
YL+L A + +VL L L N L D G L +R L +L
Sbjct: 765 YLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLS 824
Query: 735 LSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILD--ECKGLTHLKLG 792
L ++T+ K L+ L K +T+L L N I D G +++ + L +CK L L L
Sbjct: 825 LENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCK-LQTLVLQ 883
Query: 793 KNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRN-HPSLTTLSLASNG 851
+ IT G +YL+ A++ + S++ + + NQ+ G +AL N + +L L L +
Sbjct: 884 QCSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYE 942
Query: 852 ISTEGGKSLARALQQNTSLEI 872
+ E K L ++N L I
Sbjct: 943 TNLEIKKLLEEVKEKNPKLTI 963
Score = 46.2 bits (108), Expect = 1e-04
Identities = 45/153 (29%), Positives = 71/153 (46%), Gaps = 2/153 (1%)
Query: 786 LTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEAL-RNHPSLTT 844
L +L+LG + T E +K ++S+ + + N + DEGA + + R L
Sbjct: 763 LQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQM 822
Query: 845 LSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKV-NQTLKHLWL 903
LSL + ++ K LA L + L L L +N + D + L E L + L+ L L
Sbjct: 823 LSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVL 882
Query: 904 IQNQITAKGTAQLADALQSNTGITEICLNGNLI 936
Q IT G L++ALQ +T + L+ N I
Sbjct: 883 QQCSITKLGCRYLSEALQEACSLTNLDLSINQI 915
>gi|25777608 NLR family member X1 isoform 1 [Homo sapiens]
Length = 975
Score = 108 bits (271), Expect = 2e-23
Identities = 180/757 (23%), Positives = 293/757 (38%), Gaps = 125/757 (16%)
Query: 196 ETIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFSCFKESDRLCLQDLLF 255
+T+ + G G GKS L++++ W GRL A + F C S + Q L+
Sbjct: 160 QTVVLYGTVGTGKSTLVRKMVLDWCYGRLPA-FELLIPFSCEDLSSLGPAPASLCQ-LVA 217
Query: 256 KHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHPLVLLA 315
+ Y +EV + LF GL+ L+ D L+ S P EP P ++
Sbjct: 218 QRYT----PLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIV 273
Query: 316 NLLSGKLLKGASKLLTARTGI--EVPRQFLRKKVLLRGFSPSHLR-------------AY 360
NLL +L AS L+T R +P +++ + + GFS ++L+ Y
Sbjct: 274 NLLRKYMLPQASILVTTRPSAIGRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGY 333
Query: 361 A---RRMFPERALQDRLLSQL----EANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQ 413
A + A +D L+ L E + + + C +P +CW++ HF A + Q
Sbjct: 334 AVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCATL-HFLHAPTPAGQ 392
Query: 414 LPDCTMTLTDVFLLVTEVH-----LNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAH 468
TLT ++ ++ L+ PS+L +A R ++G++A+
Sbjct: 393 ------TLTSIYTSFLRLNFSGETLDSTDPSNLSLM--------AYAAR----TMGKLAY 434
Query: 469 RGMEKSLFVF--------------TQEEVQASGLQERDMQLGFLRALPELGPGGDQQSYE 514
G+ F T+EE Q + RD FL E G G ++
Sbjct: 435 EGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEPGRAG---TFV 491
Query: 515 FFHLTLQAFFTAFFLVLDDRVGT-QELLRFFQEWMPPAG---AATTSCYPPFLPFQCL-- 568
F +Q + A ++VL R T Q++ + E + G + LP + L
Sbjct: 492 FTVPAMQEYLAALYIVLGLRKTTLQKVGKEVAELVGRVGEDVSLVLGIMAKLLPLRALPL 551
Query: 569 -------------QGSGPARE--------DLFKNKDHFQFTNLFLCGLLSKAKQKLLRH- 606
+ G +RE ++F+ +D++ L G + RH
Sbjct: 552 LFNLIKVVPRVFGRMVGKSREAVAQAMVLEMFREEDYYNDDVLDQMGASILGVEGPRRHP 611
Query: 607 -------------LVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQV------ESFNQVQ 647
+ L +A+ A L ++ L +L Q + QV
Sbjct: 612 DEPPEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKN-LDALENAQAIKKKLGKLGRQVL 670
Query: 648 AMPTFIWMLRCIYETQSQKVGQLAARGICANYLKLTYCNACSADCSALSFVLHHFPKRLA 707
+ L YE Q+Q+ + L L C+ ++ VL R A
Sbjct: 671 PPSELLDHLFFHYEFQNQRFSAEVLSSL--RQLNLAGVRMTPVKCTVVAAVLGS--GRHA 726
Query: 708 LD---LDNNNLNDYGVRELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKI-VTYLGL 763
LD L + L+ G+R L P F R L L +N + K L + L + +T L L
Sbjct: 727 LDEVNLASCQLDPAGLRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRL 786
Query: 764 YNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQ 823
NN +T G + + L +THL L + EG + LA + ++ + E+ + N
Sbjct: 787 SNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNG 846
Query: 824 VGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSL 860
GD A A A A R HPSL L L N +S+EG + L
Sbjct: 847 AGDTAALALARAAREHPSLELLHLYFNELSSEGRQVL 883
Score = 46.2 bits (108), Expect = 1e-04
Identities = 38/132 (28%), Positives = 59/132 (44%), Gaps = 1/132 (0%)
Query: 816 EVGMWGNQVGDEGAKAFAEAL-RNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILW 874
++G+ N +G E K + L + +TTL L++N ++ G L L NTS+ L
Sbjct: 754 KLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLS 813
Query: 875 LTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGN 934
L L DE E LA L N+ L+ L + N LA A + + + + L N
Sbjct: 814 LLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLYFN 873
Query: 935 LIKPEEAKVYED 946
+ E +V D
Sbjct: 874 ELSSEGRQVLRD 885
>gi|25777610 NLR family member X1 isoform 2 [Homo sapiens]
Length = 921
Score = 100 bits (249), Expect = 6e-21
Identities = 175/742 (23%), Positives = 287/742 (38%), Gaps = 125/742 (16%)
Query: 196 ETIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFSCFKESDRLCLQDLLF 255
+T+ + G G GKS L++++ W GRL A + F C S + Q L+
Sbjct: 160 QTVVLYGTVGTGKSTLVRKMVLDWCYGRLPA-FELLIPFSCEDLSSLGPAPASLCQ-LVA 217
Query: 256 KHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHPLVLLA 315
+ Y +EV + LF GL+ L+ D L+ S P EP P ++
Sbjct: 218 QRYT----PLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIV 273
Query: 316 NLLSGKLLKGASKLLTARTGI--EVPRQFLRKKVLLRGFSPSHLR-------------AY 360
NLL +L AS L+T R +P +++ + + GFS ++L+ Y
Sbjct: 274 NLLRKYMLPQASILVTTRPSAIGRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGY 333
Query: 361 A---RRMFPERALQDRLLS----QLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQ 413
A + A +D L+ LE + + + C +P +CW++ HF A + Q
Sbjct: 334 AVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCATL-HFLHAPTPAGQ 392
Query: 414 LPDCTMTLTDVFLLVTEVH-----LNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAH 468
TLT ++ ++ L+ PS+L +A R ++G++A+
Sbjct: 393 ------TLTSIYTSFLRLNFSGETLDSTDPSNLSL--------MAYAAR----TMGKLAY 434
Query: 469 RGM--EKSLF------------VFTQEEVQASGLQERDMQLGFLRALPELGPGGDQQSYE 514
G+ K+ F + T+EE Q + RD FL E G G ++
Sbjct: 435 EGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEPGRAG---TFV 491
Query: 515 FFHLTLQAFFTAFFLVLDDRVGT-QELLRFFQEWMPPAG---AATTSCYPPFLPFQCL-- 568
F +Q + A ++VL R T Q++ + E + G + LP + L
Sbjct: 492 FTVPAMQEYLAALYIVLGLRKTTLQKVGKEVAELVGRVGEDVSLVLGIMAKLLPLRALPL 551
Query: 569 -------------QGSGPARE--------DLFKNKDHFQFTNLFLCGLLSKAKQKLLRH- 606
+ G +RE ++F+ +D++ L G + RH
Sbjct: 552 LFNLIKVVPRVFGRMVGKSREAVAQAMVLEMFREEDYYNDDVLDQMGASILGVEGPRRHP 611
Query: 607 -------------LVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQV------ESFNQVQ 647
+ L +A+ A L ++ L +L Q + QV
Sbjct: 612 DEPPEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKN-LDALENAQAIKKKLGKLGRQVL 670
Query: 648 AMPTFIWMLRCIYETQSQKVGQLAARGICANYLKLTYCNACSADCSALSFVLHHFPKRLA 707
+ L YE Q+Q+ + L L C+ ++ VL R A
Sbjct: 671 PPSELLDHLFFHYEFQNQRFSAEVLSSL--RQLNLAGVRMTPVKCTVVAAVLG--SGRHA 726
Query: 708 LD---LDNNNLNDYGVRELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKI-VTYLGL 763
LD L + L+ G+R L P F R L L +N + K L + L + +T L L
Sbjct: 727 LDEVNLASCQLDPAGLRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRL 786
Query: 764 YNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQ 823
NN +T G + + L +THL L + EG + LA + ++ + E+ + N
Sbjct: 787 SNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNG 846
Query: 824 VGDEGAKAFAEALRNHPSLTTL 845
GD A A A A R HPSL L
Sbjct: 847 AGDTAALALARAAREHPSLELL 868
Score = 42.4 bits (98), Expect = 0.002
Identities = 35/103 (33%), Positives = 50/103 (48%), Gaps = 3/103 (2%)
Query: 816 EVGMWGNQVGDEGAKAFAEAL-RNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILW 874
++G+ N +G E K + L + +TTL L++N ++ G L L NTS+ L
Sbjct: 754 KLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLS 813
Query: 875 LTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLA 917
L L DE E LA L N+ L+ L + N A TA LA
Sbjct: 814 LLHTGLGDEGLELLAAQLDRNRQLQELNVAYN--GAGDTAALA 854
Score = 33.1 bits (74), Expect = 1.3
Identities = 21/60 (35%), Positives = 30/60 (50%), Gaps = 1/60 (1%)
Query: 873 LWLTQNELNDEVAESLAEMLKVNQT-LKHLWLIQNQITAKGTAQLADALQSNTGITEICL 931
L L N L E + L ++L +Q + L L N +TA G A L + L NT +T + L
Sbjct: 755 LGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSL 814
>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
Length = 892
Score = 99.0 bits (245), Expect = 2e-20
Identities = 173/729 (23%), Positives = 280/729 (38%), Gaps = 105/729 (14%)
Query: 197 TIFILGDAGVGKSMLLQRLQSLWATGRLDAG-VKFFFHFRCRMFSCFKESDRLCLQDLLF 255
T+ + G AG+GK+M +++ WA G+L G V F F C + L DL+
Sbjct: 197 TVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCG--ELLERPGTRSLADLIL 254
Query: 256 KHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHPLVLLA 315
P+R +L P LF DG DEL + L + P+E A +L
Sbjct: 255 DQC--PDRGAP--VPQMLAQPQRLLFILDGADELPA-LGGPEAAPCTDPFEAASGARVLG 309
Query: 316 NLLSGKLLKGASKLLTART---GIEVPRQFLRKKVLLRGFSPSHLRAYARRMFPERALQD 372
LLS LL A L+T R G R + +RGFS + Y + F + +
Sbjct: 310 GLLSKALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAE 369
Query: 373 RLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTLTDVFLLVTEVH 432
R ++ N L +LC VP CWI+ R E L + T T V+LL
Sbjct: 370 RAYRFVKENETLFALCFVPFVCWIVCTVL---RQQLELGRDLSRTSKTTTSVYLLFITSV 426
Query: 433 LNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQASGLQERD 492
L+ +PV + L +L ++A G+ F ++E++ L+
Sbjct: 427 LSS------------APVADGPRLQGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSK 474
Query: 493 MQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRFFQEWMPPAG 552
+Q FL G + +Y+F + Q F A +L+D G
Sbjct: 475 VQTLFLSKKELPGVLETEVTYQFIDQSFQEFLAALSYLLED-----------------GG 517
Query: 553 AATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQK-LLRHLVPAA 611
T+ G G + H T FL GLLS + + + RH
Sbjct: 518 VPRTAA----------GGVGTLLRGDAQPHSHLVLTTRFLFGLLSAERMRDIERHFGCMV 567
Query: 612 ALRRKRKAL-WAH--------LFSSLRGYLKSLPRVQVESFNQVQAMPTF-IWMLRCIYE 661
+ R K++AL W + + K L + + P + + +L C+YE
Sbjct: 568 SERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPNYPLELLYCLYE 627
Query: 662 TQSQ--------KVGQLAARGI--CA-NYLKLTYCNACSADCSALSFVL----------- 699
TQ + +LA + + C + L+YC C AL +
Sbjct: 628 TQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRLISCRLVAAQEKKK 687
Query: 700 HHFPKRLALDLDNNNLNDYGVREL-----QPCFSRLT-------VLRLSVNQITDGGVKV 747
KRL L + + ++L P F +T L LS ++ D +
Sbjct: 688 KSLGKRLQASLGGGSSSQGTTKQLPASLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRD 747
Query: 748 LSEELTKYKIVTYLGLYNNQITDVGARYVTKIL--DECKGLT-HLKLGKNKITSEGGKYL 804
LSE L +T LGL +N++++ G R +++ L +C+ T ++L G +YL
Sbjct: 748 LSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCRVQTVRVQLPD---PQRGLQYL 804
Query: 805 ALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHP-SLTTLSLASNGISTEGGKSLARA 863
++ S +++ + + G Q+ L++ L TLSLAS +S + + L
Sbjct: 805 VGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQAV 864
Query: 864 LQQNTSLEI 872
+ L I
Sbjct: 865 KRAKPDLVI 873
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 93.6 bits (231), Expect = 8e-19
Identities = 181/818 (22%), Positives = 308/818 (37%), Gaps = 142/818 (17%)
Query: 197 TIFILGDAGVGKSMLLQRLQSLWATGRLDAGV-KFFFHFRCRMFSCFKESDRLCLQDLLF 255
T+ + G +G+GKS L +R+ WA G L G+ + F R KES + + +
Sbjct: 281 TVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESS---VTEFIS 337
Query: 256 KHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDL--DLSRVPDSSCPWEPAHPLVL 313
+ + D + ++ P LF DG D+L S L D D + E P L
Sbjct: 338 REW----PDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNNDTKLCKDWA---EKQPPFTL 390
Query: 314 LANLLSGKLLKGASKLLTARTGIEVPRQFLRKKV------LLRGFSPSHLRAYARRMFPE 367
+ +LL LL + ++T R +V + L+ +V L+RG S + E
Sbjct: 391 IRSLLRKVLLPESFLIVTVR---DVGTEKLKSEVVSPRYLLVRGISGEQ----RIHLLLE 443
Query: 368 RALQDRLLSQ----LEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTLTD 423
R + + +Q + N L C VP +I Q E L
Sbjct: 444 RGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHA 503
Query: 424 VFLLVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEV 483
F+ +++ P +V+R R L ++A G+ VF +++
Sbjct: 504 AFVF------HQLTPRGVVRRCLNLEE------RVVLKRFCRMAVEGVWNRKSVFDGDDL 551
Query: 484 QASGLQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRF 543
GL E +++ F + L ++ Y FFHL+LQ F A + VL+
Sbjct: 552 MVQGLGESELRALFHMNIL-LPDSHCEEYYTFFHLSLQDFCAALYYVLEG---------- 600
Query: 544 FQEWMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQKL 603
P P + H + FL GL+S+ ++
Sbjct: 601 ------------LEIEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRP 648
Query: 604 LRHLVPAAA-LRRKRKAL-WAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLRCIYE 661
L L+ L K+K L W L + P +++F+ C++E
Sbjct: 649 LEVLLGCPVPLGVKQKLLHWVSLLGQQPN--ATTPGDTLDAFH-------------CLFE 693
Query: 662 TQSQKVGQLAARGICANYLKLTYCNACSADCSALSFVLHHFP--KRLALDLDNNNLNDYG 719
TQ ++ +LA +L + + D A SF L H P +++ +D+ D
Sbjct: 694 TQDKEFVRLALNSFQEVWLPINQ----NLDLIASSFCLQHCPYLRKIRVDVKGIFPRDES 749
Query: 720 VRE--LQPCFSR---------------------LTVLRLSVNQITDGGVKVLSEELTKYK 756
+ P + R L L L + +T+ +K L +L
Sbjct: 750 AEACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPT 809
Query: 757 IVTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSK---- 812
++ N G +++ +I+ + L L LG + E + A+K+ K
Sbjct: 810 CKIQTLMFRNAQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLE 869
Query: 813 -------------------------SISEVGMWGNQVGDEGAKAFAEALR-NHPSLTTLS 846
S+ + + GN+V D+G ++ALR + +L L
Sbjct: 870 SLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLI 929
Query: 847 LASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKV-NQTLKHLWLIQ 905
L GI+ G +SLA AL N SL L L+ N L +E L +++ + +L+ L L Q
Sbjct: 930 LEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQ 989
Query: 906 NQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKV 943
+ G LA AL N+ +T + L+ N ++ K+
Sbjct: 990 CHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKL 1027
Score = 67.4 bits (163), Expect = 6e-11
Identities = 74/287 (25%), Positives = 116/287 (40%), Gaps = 39/287 (13%)
Query: 680 LKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVRELQPCF--SRLTVLRLSV 737
L+L C A +S +L P +L L N + D GV L S+ + +L +
Sbjct: 871 LRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLIL 930
Query: 738 NQ--ITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKI--LDECKGLTHLKLGK 793
IT G + L+ L + +T+L L NN + + G + + L C L L L +
Sbjct: 931 EDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCS-LQRLMLNQ 989
Query: 794 NKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPS------------ 841
+ + G +LALA+ + ++ + + N V D G K E +R PS
Sbjct: 990 CHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMRE-PSCHLQDLELVKCH 1048
Query: 842 ------------------LTTLSLASNGISTEGGKSLARALQQ-NTSLEILWLTQNELND 882
L +L L N + G +L L+Q N+ L L L L
Sbjct: 1049 LTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTS 1108
Query: 883 EVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEI 929
+ E+L+ L N+ L L L+QN + KG +L A T +I
Sbjct: 1109 DCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQI 1155
Score = 59.7 bits (143), Expect = 1e-08
Identities = 58/211 (27%), Positives = 99/211 (46%), Gaps = 5/211 (2%)
Query: 730 LTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKIL--DECKGLT 787
L LRL +T +S+ LT + L L N++TD G ++ L +C L
Sbjct: 868 LESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQC-ALQ 926
Query: 788 HLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALR-NHPSLTTLS 846
L L IT+ G + LA A+ +++S++ + + N +G+EG ++R H SL L
Sbjct: 927 KLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLM 986
Query: 847 LASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQT-LKHLWLIQ 905
L + T G LA AL N+ L L L+ N + D + L E+++ L+ L L++
Sbjct: 987 LNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVK 1046
Query: 906 NQITAKGTAQLADALQSNTGITEICLNGNLI 936
+TA L+ + + + + L N +
Sbjct: 1047 CHLTAACCESLSCVISRSRHLKSLDLTDNAL 1077
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 90.1 bits (222), Expect = 9e-18
Identities = 92/343 (26%), Positives = 146/343 (42%), Gaps = 39/343 (11%)
Query: 197 TIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFSCFKESDRLCLQDLLFK 256
T+ + G AG+GK+ L Q+L WA L K+ F+ CR S +L+F+
Sbjct: 208 TVVLYGPAGLGKTTLAQKLMLDWAEDNLIHKFKYAFYLSCRELS---RLGPCSFAELVFR 264
Query: 257 HYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHPL-VLLA 315
+ + D + A + LF DG DEL + + + D WE P+ VLL
Sbjct: 265 DWPELQDDIPHILAQARKI----LFVIDGFDELGA-APGALIEDICGDWEKKKPVPVLLG 319
Query: 316 NLLSGKLLKGASKLLTARTGIEVPRQFLRKK---VLLRGFSPSHLRAYARRMFPERALQD 372
+LL+ +L A+ L+T R + L ++ + + GF RAY R F +
Sbjct: 320 SLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAM 379
Query: 373 RLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTLTDVFLLVTEVH 432
R + +N L L S P CWI+ C +G +P C +T T +FL
Sbjct: 380 RAFELMRSNAALFQLGSAPAVCWIV--CTTLKLQMEKGEDPVPTC-LTRTGLFL---RFL 433
Query: 433 LNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQASGLQERD 492
+R + + R L +L +A +G+ V +E+++ G+QE D
Sbjct: 434 CSRFPQGAQL--------------RGALRTLSLLAAQGLWAQTSVLHREDLERLGVQESD 479
Query: 493 MQL---GFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLD 532
++L G + + G Y F HL+ Q F TA F L+
Sbjct: 480 LRLFLDGDILRQDRVSKG----CYSFIHLSFQQFLTALFYTLE 518
Score = 76.6 bits (187), Expect = 1e-13
Identities = 59/199 (29%), Positives = 93/199 (46%), Gaps = 3/199 (1%)
Query: 730 LTVLRLSVNQITDGGVKVLSEELTKYK-IVTYLGLYNNQITDVGARYVTKILDECKGLTH 788
LT + LS N++ D G K+L L K + L L N +T+ + + +L + LTH
Sbjct: 813 LTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTH 872
Query: 789 LKLGKNKITSEGGKYLALAVKNSK-SISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSL 847
L L KN I + G K+L ++ + + + +W + +G + L+ SL L L
Sbjct: 873 LCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDL 932
Query: 848 ASNGISTEGGKSLARALQQNT-SLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQN 906
N I +G K L AL++ +L LWL + E L L NQ+L L L QN
Sbjct: 933 GLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQN 992
Query: 907 QITAKGTAQLADALQSNTG 925
+ + G L + L ++G
Sbjct: 993 PLGSSGVKMLFETLTCSSG 1011
Score = 67.4 bits (163), Expect = 6e-11
Identities = 74/256 (28%), Positives = 110/256 (42%), Gaps = 37/256 (14%)
Query: 679 YLKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVRELQP------CFSR--- 729
YL L C+A + + LS L ++L +N L D G + L CF +
Sbjct: 787 YLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLS 846
Query: 730 -----------------------LTVLRLSVNQITDGGVKVLSEELT--KYKIVTYLGLY 764
LT L L+ N I + GVK L E L + K+ T L L+
Sbjct: 847 LENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQT-LVLW 905
Query: 765 NNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSK-SISEVGMWGNQ 823
N IT G +TK+L E L L LG N I +G K+L A++ ++ + +WG
Sbjct: 906 NCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCS 965
Query: 824 VGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQ-QNTSLEILWLTQNELND 882
+ + AL + SL TL L N + + G K L L + +L L L ++ ND
Sbjct: 966 IPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFND 1025
Query: 883 EVAESLAEMLKVNQTL 898
E+ + L E+ + N L
Sbjct: 1026 ELNKLLEEIEEKNPQL 1041
Score = 45.8 bits (107), Expect = 2e-04
Identities = 44/164 (26%), Positives = 71/164 (43%), Gaps = 2/164 (1%)
Query: 760 YLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKS-ISEVG 818
YLGL + T ++ L+ + LT + L N++ EG K L +++ K + +
Sbjct: 787 YLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLS 846
Query: 819 MWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQ-QNTSLEILWLTQ 877
+ + + K A L LT L LA N I G K L L+ L+ L L
Sbjct: 847 LENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWN 906
Query: 878 NELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQ 921
++ + L ++L+ +L L L N I KG L +AL+
Sbjct: 907 CDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALR 950
>gi|23503285 leucine rich repeat containing 34 [Homo sapiens]
Length = 419
Score = 89.7 bits (221), Expect = 1e-17
Identities = 75/266 (28%), Positives = 126/266 (47%), Gaps = 23/266 (8%)
Query: 680 LKLTYCNACSADCSALS-FVLH-------HFPKRLALDLDNNNLNDYGVRELQPCFSRLT 731
L+ Y N C ++ F+LH K LA + LN G L P
Sbjct: 40 LQKHYSNLCMEKSQKINPFILHILQEVDEEIKKGLAAGI---TLNIAGNNRLVP------ 90
Query: 732 VLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKL 791
V ++T +LS+ L + L + N + DVGA Y K+L + L +L L
Sbjct: 91 -----VERVTGEDFWILSKILKNCLYINGLDVGYNLLCDVGAYYAAKLLQKQLNLIYLNL 145
Query: 792 GKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNG 851
N I EGG+ +A + ++++ + M GN++ ++G FA L+ + SL L L
Sbjct: 146 MFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCD 205
Query: 852 ISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAK 911
+ E + R L++N L L + ++++ + + L + L +N +L++L + N+IT
Sbjct: 206 LE-ESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHD 264
Query: 912 GTAQLADALQSNTGITEICLNGNLIK 937
G LAD L+SNT + I L+ N I+
Sbjct: 265 GMVYLADVLKSNTTLEVIDLSFNRIE 290
Score = 73.2 bits (178), Expect = 1e-12
Identities = 56/208 (26%), Positives = 102/208 (49%), Gaps = 2/208 (0%)
Query: 733 LRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDECKGLTHLKLG 792
L + N + D G ++ L K + YL L N I G + K+L + + L +L++
Sbjct: 115 LDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMT 174
Query: 793 KNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGI 852
NKI ++GG + A ++ + S+ ++ + G+ +E L+ + L L + + I
Sbjct: 175 GNKIENKGGMFFAAMLQINSSLEKLDL-GDCDLEESTVHVGRMLKENHCLVALHMCKHDI 233
Query: 853 STEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKG 912
G + L AL N+SL L ++ N++ + LA++LK N TL+ + L N+I G
Sbjct: 234 KNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAG 293
Query: 913 TAQLADALQS-NTGITEICLNGNLIKPE 939
L++ L S N + + + N I+ E
Sbjct: 294 ANYLSETLTSHNRSLKALSVVSNNIEGE 321
Score = 60.8 bits (146), Expect = 6e-09
Identities = 60/269 (22%), Positives = 109/269 (40%), Gaps = 37/269 (13%)
Query: 708 LDLDNNNLNDYGVRELQPCFSR---LTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLY 764
LD+ N L D G + L L L N I G +++++ L K + + YL +
Sbjct: 115 LDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMT 174
Query: 765 NNQITDVGARYVTKILDECKGLTHLKLG---------------------------KNKIT 797
N+I + G + +L L L LG K+ I
Sbjct: 175 GNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVHVGRMLKENHCLVALHMCKHDIK 234
Query: 798 SEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGG 857
+ G + L A+ + S+ + + N++ +G A+ L+++ +L + L+ N I G
Sbjct: 235 NSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGA 294
Query: 858 KSLARAL-QQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQ------ITA 910
L+ L N SL+ L + N + E +L++ +K N T H+++ N+ IT
Sbjct: 295 NYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCITY 354
Query: 911 KGTAQLADALQSNTGITEICLNGNLIKPE 939
Q+ NT + ++G + E
Sbjct: 355 SDLIQMGCLKPDNTDVEPFVVDGRVYLAE 383
Score = 49.7 bits (117), Expect = 1e-05
Identities = 33/136 (24%), Positives = 70/136 (51%), Gaps = 4/136 (2%)
Query: 706 LALDLDNNNLNDYGVRELQPCF---SRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLG 762
+AL + +++ + G+++L S L L +S N+IT G+ L++ L + +
Sbjct: 224 VALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVID 283
Query: 763 LYNNQITDVGARYVTKIL-DECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWG 821
L N+I + GA Y+++ L + L L + N I EG L+ ++K + + S + +WG
Sbjct: 284 LSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWG 343
Query: 822 NQVGDEGAKAFAEALR 837
N+ + +++ ++
Sbjct: 344 NKFDEATCITYSDLIQ 359
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 88.6 bits (218), Expect = 3e-17
Identities = 74/279 (26%), Positives = 125/279 (44%), Gaps = 39/279 (13%)
Query: 680 LKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVREL------QPCFSRLTVL 733
L+L YC+ +A C L+ VL P L + NN++N+ GVR L PC +L L
Sbjct: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC--QLEAL 204
Query: 734 RLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVG-ARYVTKILDECKGLTHLKLG 792
+L +T + L + + L L +N++ DVG A +L L L +
Sbjct: 205 KLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIW 264
Query: 793 KNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKA--------------------- 831
+ IT++G L ++ +S+ E+ + GN++GDEGA+
Sbjct: 265 ECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCS 324
Query: 832 --------FAEALRNHPSLTTLSLASNGISTEGGKSLARAL-QQNTSLEILWLTQNELND 882
F+ L + L L +++N + G + L + L Q + L +LWL +++D
Sbjct: 325 FTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSD 384
Query: 883 EVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQ 921
SLA L N +L+ L L N + G QL ++++
Sbjct: 385 SSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVR 423
Score = 87.4 bits (215), Expect = 6e-17
Identities = 73/271 (26%), Positives = 124/271 (45%), Gaps = 7/271 (2%)
Query: 680 LKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGV----RELQPCFSRLTVLRL 735
++L C A C +S L P L+L +N L D GV + LQ ++ L L
Sbjct: 33 VRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSL 92
Query: 736 SVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTK-ILDECKGLTHLKLGKN 794
+T G VLS L + L L +N + D G + + + +LD L L+L
Sbjct: 93 QNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYC 152
Query: 795 KITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHP-SLTTLSLASNGIS 853
+++ + LA ++ E+ + N + + G + + L++ P L L L S G++
Sbjct: 153 SLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVT 212
Query: 854 TEGGKSLARALQQNTSLEILWLTQNELNDE-VAESLAEMLKVNQTLKHLWLIQNQITAKG 912
++ + L + SL L L N+L D +AE +L + L+ LW+ + ITAKG
Sbjct: 213 SDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKG 272
Query: 913 TAQLADALQSNTGITEICLNGNLIKPEEAKV 943
L L++ + E+ L GN + E A++
Sbjct: 273 CGDLCRVLRAKESLKELSLAGNELGDEGARL 303
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 88.6 bits (218), Expect = 3e-17
Identities = 74/279 (26%), Positives = 125/279 (44%), Gaps = 39/279 (13%)
Query: 680 LKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVREL------QPCFSRLTVL 733
L+L YC+ +A C L+ VL P L + NN++N+ GVR L PC +L L
Sbjct: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC--QLEAL 204
Query: 734 RLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVG-ARYVTKILDECKGLTHLKLG 792
+L +T + L + + L L +N++ DVG A +L L L +
Sbjct: 205 KLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIW 264
Query: 793 KNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKA--------------------- 831
+ IT++G L ++ +S+ E+ + GN++GDEGA+
Sbjct: 265 ECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCS 324
Query: 832 --------FAEALRNHPSLTTLSLASNGISTEGGKSLARAL-QQNTSLEILWLTQNELND 882
F+ L + L L +++N + G + L + L Q + L +LWL +++D
Sbjct: 325 FTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSD 384
Query: 883 EVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQ 921
SLA L N +L+ L L N + G QL ++++
Sbjct: 385 SSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVR 423
Score = 87.4 bits (215), Expect = 6e-17
Identities = 73/271 (26%), Positives = 124/271 (45%), Gaps = 7/271 (2%)
Query: 680 LKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGV----RELQPCFSRLTVLRL 735
++L C A C +S L P L+L +N L D GV + LQ ++ L L
Sbjct: 33 VRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSL 92
Query: 736 SVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTK-ILDECKGLTHLKLGKN 794
+T G VLS L + L L +N + D G + + + +LD L L+L
Sbjct: 93 QNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYC 152
Query: 795 KITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHP-SLTTLSLASNGIS 853
+++ + LA ++ E+ + N + + G + + L++ P L L L S G++
Sbjct: 153 SLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVT 212
Query: 854 TEGGKSLARALQQNTSLEILWLTQNELNDE-VAESLAEMLKVNQTLKHLWLIQNQITAKG 912
++ + L + SL L L N+L D +AE +L + L+ LW+ + ITAKG
Sbjct: 213 SDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKG 272
Query: 913 TAQLADALQSNTGITEICLNGNLIKPEEAKV 943
L L++ + E+ L GN + E A++
Sbjct: 273 CGDLCRVLRAKESLKELSLAGNELGDEGARL 303
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 88.6 bits (218), Expect = 3e-17
Identities = 74/279 (26%), Positives = 125/279 (44%), Gaps = 39/279 (13%)
Query: 680 LKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVREL------QPCFSRLTVL 733
L+L YC+ +A C L+ VL P L + NN++N+ GVR L PC +L L
Sbjct: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC--QLEAL 204
Query: 734 RLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVG-ARYVTKILDECKGLTHLKLG 792
+L +T + L + + L L +N++ DVG A +L L L +
Sbjct: 205 KLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIW 264
Query: 793 KNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKA--------------------- 831
+ IT++G L ++ +S+ E+ + GN++GDEGA+
Sbjct: 265 ECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCS 324
Query: 832 --------FAEALRNHPSLTTLSLASNGISTEGGKSLARAL-QQNTSLEILWLTQNELND 882
F+ L + L L +++N + G + L + L Q + L +LWL +++D
Sbjct: 325 FTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSD 384
Query: 883 EVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQ 921
SLA L N +L+ L L N + G QL ++++
Sbjct: 385 SSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVR 423
Score = 87.4 bits (215), Expect = 6e-17
Identities = 73/271 (26%), Positives = 124/271 (45%), Gaps = 7/271 (2%)
Query: 680 LKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGV----RELQPCFSRLTVLRL 735
++L C A C +S L P L+L +N L D GV + LQ ++ L L
Sbjct: 33 VRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSL 92
Query: 736 SVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTK-ILDECKGLTHLKLGKN 794
+T G VLS L + L L +N + D G + + + +LD L L+L
Sbjct: 93 QNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYC 152
Query: 795 KITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHP-SLTTLSLASNGIS 853
+++ + LA ++ E+ + N + + G + + L++ P L L L S G++
Sbjct: 153 SLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVT 212
Query: 854 TEGGKSLARALQQNTSLEILWLTQNELNDE-VAESLAEMLKVNQTLKHLWLIQNQITAKG 912
++ + L + SL L L N+L D +AE +L + L+ LW+ + ITAKG
Sbjct: 213 SDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKG 272
Query: 913 TAQLADALQSNTGITEICLNGNLIKPEEAKV 943
L L++ + E+ L GN + E A++
Sbjct: 273 CGDLCRVLRAKESLKELSLAGNELGDEGARL 303
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,336,728
Number of Sequences: 37866
Number of extensions: 1548659
Number of successful extensions: 4511
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 39
Number of HSP's that attempted gapping in prelim test: 3807
Number of HSP's gapped (non-prelim): 364
length of query: 953
length of database: 18,247,518
effective HSP length: 112
effective length of query: 841
effective length of database: 14,006,526
effective search space: 11779488366
effective search space used: 11779488366
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.