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Search of human proteins with 50980301
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50980301 myosin phosphatase-Rho interacting protein isoform
2 [Homo sapiens]
(1025 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50980301 myosin phosphatase-Rho interacting protein isoform 2... 2044 0.0
gi|50980307 myosin phosphatase-Rho interacting protein isoform 1... 2026 0.0
gi|88501740 TRIO and F-actin binding protein isoform 1 [Homo sap... 475 e-134
gi|88501738 TRIO and F-actin binding protein isoform 6 [Homo sap... 474 e-133
gi|88501741 TRIO and F-actin binding protein isoform 2 [Homo sap... 236 6e-62
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 79 2e-14
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 79 2e-14
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 79 2e-14
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 79 2e-14
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 75 2e-13
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 75 2e-13
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 75 2e-13
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 75 2e-13
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 75 2e-13
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 75 2e-13
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 75 2e-13
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 75 2e-13
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 72 2e-12
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 72 3e-12
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 72 3e-12
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 72 3e-12
gi|58530840 desmoplakin isoform I [Homo sapiens] 69 2e-11
gi|148746195 trichohyalin [Homo sapiens] 69 2e-11
gi|58535453 CDK5 regulatory subunit associated protein 2 isoform... 68 4e-11
gi|58535451 CDK5 regulatory subunit associated protein 2 isoform... 68 4e-11
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 68 4e-11
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens] 68 4e-11
gi|38044112 restin isoform b [Homo sapiens] 67 1e-10
gi|4506751 restin isoform a [Homo sapiens] 67 1e-10
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 66 2e-10
>gi|50980301 myosin phosphatase-Rho interacting protein isoform 2
[Homo sapiens]
Length = 1025
Score = 2044 bits (5295), Expect = 0.0
Identities = 1025/1025 (100%), Positives = 1025/1025 (100%)
Query: 1 MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFD 60
MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFD
Sbjct: 1 MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFD 60
Query: 61 NPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQKFSLC 120
NPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQKFSLC
Sbjct: 61 NPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQKFSLC 120
Query: 121 ILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVAVTSS 180
ILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVAVTSS
Sbjct: 121 ILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVAVTSS 180
Query: 181 SSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSLREPG 240
SSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSLREPG
Sbjct: 181 SSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSLREPG 240
Query: 241 LESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTPNHRR 300
LESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTPNHRR
Sbjct: 241 LESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTPNHRR 300
Query: 301 SQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPDAS 360
SQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPDAS
Sbjct: 301 SQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPDAS 360
Query: 361 ASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYYRD 420
ASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYYRD
Sbjct: 361 ASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYYRD 420
Query: 421 SVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMK 480
SVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMK
Sbjct: 421 SVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMK 480
Query: 481 HVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRS 540
HVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRS
Sbjct: 481 HVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRS 540
Query: 541 KTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLD 600
KTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLD
Sbjct: 541 KTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLD 600
Query: 601 ATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVH 660
ATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVH
Sbjct: 601 ATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVH 660
Query: 661 LSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVL 720
LSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVL
Sbjct: 661 LSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVL 720
Query: 721 QATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHR 780
QATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHR
Sbjct: 721 QATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHR 780
Query: 781 EEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQA 840
EEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQA
Sbjct: 781 EEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQA 840
Query: 841 LEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAY 900
LEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAY
Sbjct: 841 LEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAY 900
Query: 901 ELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDIS 960
ELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDIS
Sbjct: 901 ELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDIS 960
Query: 961 RLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSVIEQ 1020
RLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSVIEQ
Sbjct: 961 RLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSVIEQ 1020
Query: 1021 VSWDT 1025
VSWDT
Sbjct: 1021 VSWDT 1025
>gi|50980307 myosin phosphatase-Rho interacting protein isoform 1
[Homo sapiens]
Length = 1038
Score = 2026 bits (5250), Expect = 0.0
Identities = 1017/1019 (99%), Positives = 1018/1019 (99%)
Query: 1 MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFD 60
MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFD
Sbjct: 1 MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFD 60
Query: 61 NPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQKFSLC 120
NPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQKFSLC
Sbjct: 61 NPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQKFSLC 120
Query: 121 ILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVAVTSS 180
ILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVAVTSS
Sbjct: 121 ILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVAVTSS 180
Query: 181 SSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSLREPG 240
SSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSLREPG
Sbjct: 181 SSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSLREPG 240
Query: 241 LESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTPNHRR 300
LESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTPNHRR
Sbjct: 241 LESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTPNHRR 300
Query: 301 SQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPDAS 360
SQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPDAS
Sbjct: 301 SQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPDAS 360
Query: 361 ASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYYRD 420
ASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYYRD
Sbjct: 361 ASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYYRD 420
Query: 421 SVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMK 480
SVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMK
Sbjct: 421 SVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMK 480
Query: 481 HVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRS 540
HVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRS
Sbjct: 481 HVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRS 540
Query: 541 KTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLD 600
KTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLD
Sbjct: 541 KTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLD 600
Query: 601 ATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVH 660
ATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVH
Sbjct: 601 ATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVH 660
Query: 661 LSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVL 720
LSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVL
Sbjct: 661 LSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVL 720
Query: 721 QATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHR 780
QATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHR
Sbjct: 721 QATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHR 780
Query: 781 EEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQA 840
EEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQA
Sbjct: 781 EEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQA 840
Query: 841 LEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAY 900
LEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAY
Sbjct: 841 LEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAY 900
Query: 901 ELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDIS 960
ELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDIS
Sbjct: 901 ELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDIS 960
Query: 961 RLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSVIE 1019
RLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKS+ E
Sbjct: 961 RLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSLKE 1019
>gi|88501740 TRIO and F-actin binding protein isoform 1 [Homo
sapiens]
Length = 652
Score = 475 bits (1223), Expect = e-134
Identities = 289/668 (43%), Positives = 396/668 (59%), Gaps = 45/668 (6%)
Query: 324 GPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPDASASPLSPHRRAKSLDRRSTEPSVT 383
GP + +RA R PAP A P R+ L ++T
Sbjct: 6 GPGQRRGKEGPEARRRAAERGGGGGGGGVPAPRSPAR----EPRPRSCLLLPPPWGAAMT 61
Query: 384 PDLLNFKKGWLTKQYEDG-------------QWKKHWFVLADQSLRYYRDSVAEEAADLD 430
PDLLNFKKGW++ E G QWKKHWFVL D SL+YYRDS AEEA +LD
Sbjct: 62 PDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELD 121
Query: 431 GEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMKHVHPTTAPDV 490
GEIDL +C DVTEY VQRNYGFQIHTK+ +TLSAMTSGIRRNWI+ + K V PT+APDV
Sbjct: 122 GEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDV 181
Query: 491 TSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRP 550
T K + S+ T P + E G + SR R+ +G+ + D+ E P
Sbjct: 182 TKLSDSNKENALHSYSTQKGPLKAGEQRAG----SEVISRGGPRKADGQRQALDYVELSP 237
Query: 551 IQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLDATDGPGTEDA 610
+ QA Q PA T + L A+ ELER+ A+R EERRK F +ATD T +
Sbjct: 238 LTQASPQR---ARTPARTPDRL---AKQEELERDLAQRSEERRKWF---EATDS-RTPEV 287
Query: 611 ALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRL 670
R G P+++ + + + EIE++W ++E PLRE K+VP+ + L+ G R
Sbjct: 288 PAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTAL-LNQSRGERRG 346
Query: 671 STHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAR--EGYVLQATCERGF 728
+ LEKE++ + + LE RL + + AL ++ GY+ Q CER
Sbjct: 347 PPSDGHEALEKEVQALRAQ----LEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSL 402
Query: 729 AAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELE 788
A ME +HQ+ +E+LQR H+REL++L++EK+ LLAEETAAT SAIEAMK A++EE+ REL
Sbjct: 403 AEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELS 462
Query: 789 KSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQAL 848
K++ S+ + LR+Q+ ++++++REL+VLSEQYSQKCLE L + E L
Sbjct: 463 KTR-----SLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTL 517
Query: 849 RQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRV 908
R+CQ+E QEL HNQEL+ RL+ EI +LR + G G G + + + ELEVLLRV
Sbjct: 518 RRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGR--SNERSSCELEVLLRV 575
Query: 909 KESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKA 968
KE+E+QYLK+E+ L+DELQ +DK++ S KY+D+Y ELS K +++ +I +LKE L+
Sbjct: 576 KENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRL 635
Query: 969 ATEALGEK 976
A AL EK
Sbjct: 636 AMAALQEK 643
>gi|88501738 TRIO and F-actin binding protein isoform 6 [Homo sapiens]
Length = 2365
Score = 474 bits (1219), Expect = e-133
Identities = 293/703 (41%), Positives = 400/703 (56%), Gaps = 81/703 (11%)
Query: 324 GPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPDASASPLSPHRRAKSLDRRSTEPSV- 382
GP S T +G S F E P P PL+ ++A S D+R E
Sbjct: 1685 GPLGSRSTAKGPSLPEL-----QFQPEEPEESEPSRGQDPLTDQKQADSADKRPAEGKAG 1739
Query: 383 ----------------------------------TPDLLNFKKGWLTKQYEDG------- 401
PDLLNFKKGW++ E G
Sbjct: 1740 SPLKGRLVTSWRMPGDRPTLFNPFLLSLGVLRWRRPDLLNFKKGWMSILDEPGEPPSPSL 1799
Query: 402 ------QWKKHWFVLADQSLRYYRDSVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIH 455
QWKKHWFVL D SL+YYRDS AEEA +LDGEIDL +C DVTEY VQRNYGFQIH
Sbjct: 1800 TTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIH 1859
Query: 456 TKEGEFTLSAMTSGIRRNWIQTIMKHVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQ 515
TK+ +TLSAMTSGIRRNWI+ + K V PT+APDVT K + S+ T P +
Sbjct: 1860 TKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLKAG 1919
Query: 516 EAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPE 575
E G + SR R+ +G+ + D+ E P+ QA Q PA T + L
Sbjct: 1920 EQRAG----SEVISRGGPRKADGQRQALDYVELSPLTQASPQR---ARTPARTPDRL--- 1969
Query: 576 AEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVE 635
A+ ELER+ A+R EERRK F +ATD T + R G P+++ + + + E
Sbjct: 1970 AKQEELERDLAQRSEERRKWF---EATDS-RTPEVPAGEGPRRGLGAPLTEDQQNRLSEE 2025
Query: 636 IEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLE 695
IE++W ++E PLRE K+VP+ + L+ G R + LEKE++ + + LE
Sbjct: 2026 IEKKWQELEKLPLRENKRVPLTAL-LNQSRGERRGPPSDGHEALEKEVQALRAQ----LE 2080
Query: 696 QNRLLQDQLRVALGREQSAR--EGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKL 753
RL + + AL ++ GY+ Q CER A ME +HQ+ +E+LQR H+REL++L
Sbjct: 2081 AWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRL 2140
Query: 754 REEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEEL 813
++EK+ LLAEETAAT SAIEAMK A++EE+ REL K++ S+ + LR+Q+ ++
Sbjct: 2141 QQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTR-----SLQQGPDGLRKQHQSDV 2195
Query: 814 QSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEI 873
++++REL+VLSEQYSQKCLE L + E LR+CQ+E QEL HNQEL+ RL+ EI
Sbjct: 2196 EALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEI 2255
Query: 874 TRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRD 933
+LR + G G G + + + ELEVLLRVKE+E+QYLK+E+ L+DELQ +D
Sbjct: 2256 DQLRGFIASQGMGNGCGR--SNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKD 2313
Query: 934 KKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEALGEK 976
K++ S KY+D+Y ELS K +++ +I +LKE L+ A AL EK
Sbjct: 2314 KRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEK 2356
Score = 38.9 bits (89), Expect = 0.025
Identities = 13/24 (54%), Positives = 18/24 (75%)
Query: 9 CRKFQANIFNKSKCQNCFKPRESH 32
C F+ANI +++CQNCF P E+H
Sbjct: 10 CEHFEANILTQNRCQNCFHPEEAH 33
>gi|88501741 TRIO and F-actin binding protein isoform 2 [Homo
sapiens]
Length = 431
Score = 236 bits (603), Expect = 6e-62
Identities = 162/413 (39%), Positives = 217/413 (52%), Gaps = 38/413 (9%)
Query: 324 GPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPDASASPLSPHRRAKSLDRRSTEPSVT 383
GP + +RA R PAP A P R+ L ++T
Sbjct: 6 GPGQRRGKEGPEARRRAAERGGGGGGGGVPAPRSPAR----EPRPRSCLLLPPPWGAAMT 61
Query: 384 PDLLNFKKGWLTKQYEDG-------------QWKKHWFVLADQSLRYYRDSVAEEAADLD 430
PDLLNFKKGW++ E G QWKKHWFVL D SL+YYRDS AEEA +LD
Sbjct: 62 PDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELD 121
Query: 431 GEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMKHVHPTTAPDV 490
GEIDL +C DVTEY VQRNYGFQIHTK+ +TLSAMTSGIRRNWI+ + K V PT+APDV
Sbjct: 122 GEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDV 181
Query: 491 TSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRP 550
T K + S+ T P + E G + SR R+ +G+ + D+ E P
Sbjct: 182 TKLSDSNKENALHSYSTQKGPLKAGEQRAG----SEVISRGGPRKADGQRQALDYVELSP 237
Query: 551 IQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLDATDGPGTEDA 610
+ QA Q PA T + L A+ ELER+ A+R EERRK F +ATD T +
Sbjct: 238 LTQASPQR---ARTPARTPDRL---AKQEELERDLAQRSEERRKWF---EATDS-RTPEV 287
Query: 611 ALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRL 670
R G P+++ + + + EIE++W ++E PLRE K+VP+ + L+ G R
Sbjct: 288 PAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTAL-LNQSRGERRG 346
Query: 671 STHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAR--EGYVLQ 721
+ LEKE++ + + LE RL + + AL ++ GY+ Q
Sbjct: 347 PPSDGHEALEKEVQALRAQ----LEAWRLQGEAPQSALRSQEDGHIPPGYISQ 395
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 79.0 bits (193), Expect = 2e-14
Identities = 110/468 (23%), Positives = 205/468 (43%), Gaps = 69/468 (14%)
Query: 527 KRSRARERRREGRSKTFDWAEFRPIQQALAQ----ERVGGVGPADTHEPLRPEAEPG--- 579
+R RA RE +K A R +++AL ER + A+ + + + + G
Sbjct: 1470 ERDRAEAEAREKETKALSLA--RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV 1527
Query: 580 -ELERERARRREERRKRFGMLDATDGP--GTEDAALRMEVDRSP-------GLPMSDLKT 629
ELE+ + + + L+ + TEDA LR+EV+ L D +
Sbjct: 1528 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1587
Query: 630 HNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKE 689
+++++ H+ ET E KQ +A +G LE + + + K
Sbjct: 1588 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD--------LKDLELQADSAIKG 1639
Query: 690 ASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRE 749
+ ++Q R LQ Q++ + AR A+ + FA +E ++KK + L+ +
Sbjct: 1640 REEAIKQLRKLQAQMKDFQRELEDAR------ASRDEIFATAKE-NEKKAKSLEA----D 1688
Query: 750 LEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQ--RSQISSVNSDVEALRR 807
L +L+E+ L A E A + +E +EE+ EL S R+ + +EA
Sbjct: 1689 LMQLQED---LAAAERARKQADLE------KEELAEELASSLSGRNALQDEKRRLEARIA 1739
Query: 808 QYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNN 867
Q EEL+ Q +E +S++ + + L+ L ER ++ + Q+L N+EL +
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 868 RL----AAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSL 923
+L A ++ ++ + A + +AQ ++ E E R K++ + LKQ+ L
Sbjct: 1800 KLHEMEGAVKSKFKSTIA------ALEAKIAQLEEQVEQEA--REKQAATKSLKQKDKKL 1851
Query: 924 KDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATE 971
K E+ + D++ +++YK+ K + + +LK QL+ A E
Sbjct: 1852 K-EILLQVEDERKMAEQYKE-------QAEKGNARVKQLKRQLEEAEE 1891
Score = 63.9 bits (154), Expect = 7e-10
Identities = 83/343 (24%), Positives = 153/343 (44%), Gaps = 32/343 (9%)
Query: 656 IAPVHLSSEDGGDRLSTHELT-SLLEKELEQSQKEASDLLEQ---NRLLQDQLRVALGRE 711
I+ +++ D +L T LE+ ++ QKE +L +Q D+L R
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1425
Query: 712 QSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAE----ETAA 767
Q + V+ +R + E Q+K + L + + K +E+DR AE ET A
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485
Query: 768 TISAIEAMKNA--HREEMER--ELEKSQRSQISSVNSDV-------EALRRQYLEELQSV 816
+S A++ A +EE+ER ++ K++ + S DV E +R +++ +
Sbjct: 1486 -LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1544
Query: 817 QRELEVLSEQYSQKCLENAHLAQALEAERQALR-QCQRENQELNAHNQELNNRLAAEITR 875
+ +LE L ++ + E+A L LE QAL+ Q +R+ Q + N+E +L ++
Sbjct: 1545 KTQLEELEDEL--QATEDAKL--RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 876 LRTLLTGDGGGEATGSPLAQ--GKDAYELEV----LLRVKESEIQYLKQEISSLKDELQT 929
T L + A + + D +LE+ ++ +E I+ L++ + +KD Q
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD-FQR 1659
Query: 930 ALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEA 972
L D + + D+ E + D+ +L+E L AA A
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1702
Score = 59.3 bits (142), Expect = 2e-08
Identities = 119/525 (22%), Positives = 218/525 (41%), Gaps = 77/525 (14%)
Query: 514 KQEAELGEPDPEQKRSRARERRR----EGRSKTFDWAEFRPIQQALAQERVGGVGPADTH 569
+Q+AE + EQK S+ E + + +++T +AE ++ LA ++ +
Sbjct: 868 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK------QELE 921
Query: 570 EPLRPEAEPGELERERARRREERRKRFG--MLDATDGPGTEDAAL-RMEVDRSPGLPMSD 626
E L E E +R ++ + RK+ MLD + E+AA ++++++
Sbjct: 922 EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 981
Query: 627 LKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLST----HE-LTSLLEK 681
+ V +Q + L EE+ + E+ L+ HE + S LE
Sbjct: 982 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1041
Query: 682 ELEQSQKEASDLLEQNRLLQD------------QLRVALGREQSAREGYVLQATCER--G 727
L++ +K +L + R L+ Q ++A + Q A++ LQA R
Sbjct: 1042 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD 1101
Query: 728 FAAMEETHQKKIEDLQ---RQHQRELEKLR------EEKDRLLAEETAATISAIEAMKN- 777
A + KKI +L+ Q +L+ R E++ R L EE A + +E +
Sbjct: 1102 EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS 1161
Query: 778 --------AHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVL------ 823
A RE+ L+K+ + S + V+ +R+++ + ++ + +LE
Sbjct: 1162 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN 1221
Query: 824 ---SEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNR----------LA 870
++Q +K ENA LA L QA ++ + + ++L A QEL ++ L
Sbjct: 1222 LDKNKQTLEK--ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN 1279
Query: 871 AEITRLRTLLTGDGG--GEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQ 928
++ +L+ + G EA G + KD L L+ + Q L QE + K +
Sbjct: 1280 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ----DTQELLQEETRQKLNVS 1335
Query: 929 TALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEAL 973
T LR + + +D E AK + IS L QL + + L
Sbjct: 1336 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380
Score = 53.5 bits (127), Expect = 1e-06
Identities = 76/323 (23%), Positives = 139/323 (43%), Gaps = 34/323 (10%)
Query: 672 THELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAM 731
T E E EL++ +++ S L E+ LLQ+QL+ A E V A
Sbjct: 864 TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA--------- 914
Query: 732 EETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQ 791
++++E++ + + LE+ + +L AE ++ E++E E Q
Sbjct: 915 --AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL-----EEQLEEEEAARQ 967
Query: 792 RSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLEN--AHLAQALEAERQALR 849
+ Q+ V + EA ++ +E+ + + LS++ +K LE + L L E + +
Sbjct: 968 KLQLEKVTA--EAKIKKLEDEILVMDDQNNKLSKE--RKLLEERISDLTTNLAEEEEKAK 1023
Query: 850 QCQRENQELNAHNQELNNRL------AAEITRLRTLLTGDGGGEATGSPLAQGKDAYELE 903
+ + + EL RL E+ +L+ L GD Q + A EL+
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA-ELK 1082
Query: 904 VLLRVKESEIQ----YLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDI 959
+ L KE E+Q L EI+ + L+ + + SD +D+ +E + A+ KA+
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA-ARNKAEKQK 1141
Query: 960 SRLKEQLKAATEALGEKSPDSAT 982
L E+L+A L + +AT
Sbjct: 1142 RDLGEELEALKTELEDTLDSTAT 1164
Score = 48.5 bits (114), Expect = 3e-05
Identities = 62/249 (24%), Positives = 115/249 (46%), Gaps = 47/249 (18%)
Query: 679 LEKELEQSQKEASDLLEQNRLLQD----QLRVALGREQSAREGYVLQATCERGFAAMEET 734
LEKE E +++ AS L +N L + + R+A E+ E ++A +R A ++
Sbjct: 1708 LEKE-ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1766
Query: 735 HQ------------KKIEDLQRQHQRELEKLRE---EKDRLLAEETAATISAIEAMKNAH 779
Q +K E ++Q +R+ ++LR E + + + +TI+A+EA
Sbjct: 1767 EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1826
Query: 780 REEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLE-NAHLA 838
E++E+E + Q + S D ++ E L V+ E + ++EQY ++ + NA +
Sbjct: 1827 EEQVEQEAREKQAATKSLKQKD-----KKLKEILLQVEDERK-MAEQYKEQAEKGNARVK 1880
Query: 839 QALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKD 898
Q ++ L + + E+Q +NA+ ++L L EAT S A G++
Sbjct: 1881 QL----KRQLEEAEEESQRINANRRKLQREL----------------DEATESNEAMGRE 1920
Query: 899 AYELEVLLR 907
L+ LR
Sbjct: 1921 VNALKSKLR 1929
Score = 41.2 bits (95), Expect = 0.005
Identities = 68/295 (23%), Positives = 126/295 (42%), Gaps = 73/295 (24%)
Query: 719 VLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNA 778
+LQ T + +E +K ++ Q++ + EL++L E+K L EE KN
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKEL-EQKHSQLTEE-----------KNL 891
Query: 779 HREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLA 838
+E+++ E E + ++ E +R + L + ++ELE + + + E
Sbjct: 892 LQEQLQAETE---------LYAEAEEMRVR----LAAKKQELEEILHEMEARLEEEEDRG 938
Query: 839 QALEAERQALRQ----CQRENQELNAHNQEL------------------------NNRLA 870
Q L+AER+ + Q + + +E A Q+L NN+L+
Sbjct: 939 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998
Query: 871 AE----ITRLRTLLTGDGGGEATGSPLAQGKDAY-----ELEVLLRVKESEIQYLKQEIS 921
E R+ L T E L + K+ + ELEV L+ +E +QE+
Sbjct: 999 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS----RQELE 1054
Query: 922 SLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEALGEK 976
LK +L+ ASD ++ I +L A+ +++ +E+L+AA L ++
Sbjct: 1055 KLKRKLEGD------ASDFHEQI-ADLQAQIAELKMQLAKKEEELQAALARLDDE 1102
Score = 38.9 bits (89), Expect = 0.025
Identities = 75/367 (20%), Positives = 149/367 (40%), Gaps = 40/367 (10%)
Query: 521 EPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGE 580
E D + + + E+RR+ + + ++ + L ER A + L + + E
Sbjct: 1577 ERDLQARDEQNEEKRRQLQRQLHEY------ETELEDERKQRALAAAAKKKLEGDLKDLE 1630
Query: 581 LERERA-RRREERRKRFGMLDATDGP---GTEDA-ALRMEVDRSPGLPMSDLKTHNVHVE 635
L+ + A + REE K+ L A EDA A R E+ + ++ K ++ +
Sbjct: 1631 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA--KENEKKAKSLEAD 1688
Query: 636 IEQRWHQVETTPLREEKQVPIAPVHLSSEDGGD---RLSTHELTSLLEKELEQSQKEASD 692
+ Q + R KQ + L+ E R + + LE + Q ++E +
Sbjct: 1689 LMQLQEDLAAAE-RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1747
Query: 693 LLEQNRLLQDQLRVALGR-EQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRE-- 749
+ D++R A + EQ + E ++T ++ +A ++ ++ E + H+ E
Sbjct: 1748 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1807
Query: 750 ---------------LEKLREEKDRLLAEETAATISAIEAMKNAH----REEMERELEKS 790
+ +L E+ ++ E+ AAT S + K + E ER++ +
Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1867
Query: 791 QRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQ 850
+ Q N+ V+ L+RQ LEE + + + + ++ E +A+ E AL+
Sbjct: 1868 YKEQAEKGNARVKQLKRQ-LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1926
Query: 851 CQRENQE 857
R E
Sbjct: 1927 KLRRGNE 1933
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 79.0 bits (193), Expect = 2e-14
Identities = 110/468 (23%), Positives = 205/468 (43%), Gaps = 69/468 (14%)
Query: 527 KRSRARERRREGRSKTFDWAEFRPIQQALAQ----ERVGGVGPADTHEPLRPEAEPG--- 579
+R RA RE +K A R +++AL ER + A+ + + + + G
Sbjct: 1477 ERDRAEAEAREKETKALSLA--RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV 1534
Query: 580 -ELERERARRREERRKRFGMLDATDGP--GTEDAALRMEVDRSP-------GLPMSDLKT 629
ELE+ + + + L+ + TEDA LR+EV+ L D +
Sbjct: 1535 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1594
Query: 630 HNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKE 689
+++++ H+ ET E KQ +A +G LE + + + K
Sbjct: 1595 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD--------LKDLELQADSAIKG 1646
Query: 690 ASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRE 749
+ ++Q R LQ Q++ + AR A+ + FA +E ++KK + L+ +
Sbjct: 1647 REEAIKQLRKLQAQMKDFQRELEDAR------ASRDEIFATAKE-NEKKAKSLEA----D 1695
Query: 750 LEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQ--RSQISSVNSDVEALRR 807
L +L+E+ L A E A + +E +EE+ EL S R+ + +EA
Sbjct: 1696 LMQLQED---LAAAERARKQADLE------KEELAEELASSLSGRNALQDEKRRLEARIA 1746
Query: 808 QYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNN 867
Q EEL+ Q +E +S++ + + L+ L ER ++ + Q+L N+EL +
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806
Query: 868 RL----AAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSL 923
+L A ++ ++ + A + +AQ ++ E E R K++ + LKQ+ L
Sbjct: 1807 KLHEMEGAVKSKFKSTIA------ALEAKIAQLEEQVEQEA--REKQAATKSLKQKDKKL 1858
Query: 924 KDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATE 971
K E+ + D++ +++YK+ K + + +LK QL+ A E
Sbjct: 1859 K-EILLQVEDERKMAEQYKE-------QAEKGNARVKQLKRQLEEAEE 1898
Score = 63.9 bits (154), Expect = 7e-10
Identities = 83/343 (24%), Positives = 153/343 (44%), Gaps = 32/343 (9%)
Query: 656 IAPVHLSSEDGGDRLSTHELT-SLLEKELEQSQKEASDLLEQ---NRLLQDQLRVALGRE 711
I+ +++ D +L T LE+ ++ QKE +L +Q D+L R
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1432
Query: 712 QSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAE----ETAA 767
Q + V+ +R + E Q+K + L + + K +E+DR AE ET A
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492
Query: 768 TISAIEAMKNA--HREEMER--ELEKSQRSQISSVNSDV-------EALRRQYLEELQSV 816
+S A++ A +EE+ER ++ K++ + S DV E +R +++ +
Sbjct: 1493 -LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1551
Query: 817 QRELEVLSEQYSQKCLENAHLAQALEAERQALR-QCQRENQELNAHNQELNNRLAAEITR 875
+ +LE L ++ + E+A L LE QAL+ Q +R+ Q + N+E +L ++
Sbjct: 1552 KTQLEELEDEL--QATEDAKL--RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 876 LRTLLTGDGGGEATGSPLAQ--GKDAYELEV----LLRVKESEIQYLKQEISSLKDELQT 929
T L + A + + D +LE+ ++ +E I+ L++ + +KD Q
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD-FQR 1666
Query: 930 ALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEA 972
L D + + D+ E + D+ +L+E L AA A
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1709
Score = 59.3 bits (142), Expect = 2e-08
Identities = 119/525 (22%), Positives = 218/525 (41%), Gaps = 77/525 (14%)
Query: 514 KQEAELGEPDPEQKRSRARERRR----EGRSKTFDWAEFRPIQQALAQERVGGVGPADTH 569
+Q+AE + EQK S+ E + + +++T +AE ++ LA ++ +
Sbjct: 875 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK------QELE 928
Query: 570 EPLRPEAEPGELERERARRREERRKRFG--MLDATDGPGTEDAAL-RMEVDRSPGLPMSD 626
E L E E +R ++ + RK+ MLD + E+AA ++++++
Sbjct: 929 EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 988
Query: 627 LKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLST----HE-LTSLLEK 681
+ V +Q + L EE+ + E+ L+ HE + S LE
Sbjct: 989 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1048
Query: 682 ELEQSQKEASDLLEQNRLLQD------------QLRVALGREQSAREGYVLQATCER--G 727
L++ +K +L + R L+ Q ++A + Q A++ LQA R
Sbjct: 1049 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD 1108
Query: 728 FAAMEETHQKKIEDLQ---RQHQRELEKLR------EEKDRLLAEETAATISAIEAMKN- 777
A + KKI +L+ Q +L+ R E++ R L EE A + +E +
Sbjct: 1109 EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS 1168
Query: 778 --------AHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVL------ 823
A RE+ L+K+ + S + V+ +R+++ + ++ + +LE
Sbjct: 1169 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN 1228
Query: 824 ---SEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNR----------LA 870
++Q +K ENA LA L QA ++ + + ++L A QEL ++ L
Sbjct: 1229 LDKNKQTLEK--ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN 1286
Query: 871 AEITRLRTLLTGDGG--GEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQ 928
++ +L+ + G EA G + KD L L+ + Q L QE + K +
Sbjct: 1287 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ----DTQELLQEETRQKLNVS 1342
Query: 929 TALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEAL 973
T LR + + +D E AK + IS L QL + + L
Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387
Score = 53.5 bits (127), Expect = 1e-06
Identities = 76/323 (23%), Positives = 139/323 (43%), Gaps = 34/323 (10%)
Query: 672 THELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAM 731
T E E EL++ +++ S L E+ LLQ+QL+ A E V A
Sbjct: 871 TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA--------- 921
Query: 732 EETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQ 791
++++E++ + + LE+ + +L AE ++ E++E E Q
Sbjct: 922 --AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL-----EEQLEEEEAARQ 974
Query: 792 RSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLEN--AHLAQALEAERQALR 849
+ Q+ V + EA ++ +E+ + + LS++ +K LE + L L E + +
Sbjct: 975 KLQLEKVTA--EAKIKKLEDEILVMDDQNNKLSKE--RKLLEERISDLTTNLAEEEEKAK 1030
Query: 850 QCQRENQELNAHNQELNNRL------AAEITRLRTLLTGDGGGEATGSPLAQGKDAYELE 903
+ + + EL RL E+ +L+ L GD Q + A EL+
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA-ELK 1089
Query: 904 VLLRVKESEIQ----YLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDI 959
+ L KE E+Q L EI+ + L+ + + SD +D+ +E + A+ KA+
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA-ARNKAEKQK 1148
Query: 960 SRLKEQLKAATEALGEKSPDSAT 982
L E+L+A L + +AT
Sbjct: 1149 RDLGEELEALKTELEDTLDSTAT 1171
Score = 48.5 bits (114), Expect = 3e-05
Identities = 62/249 (24%), Positives = 115/249 (46%), Gaps = 47/249 (18%)
Query: 679 LEKELEQSQKEASDLLEQNRLLQD----QLRVALGREQSAREGYVLQATCERGFAAMEET 734
LEKE E +++ AS L +N L + + R+A E+ E ++A +R A ++
Sbjct: 1715 LEKE-ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1773
Query: 735 HQ------------KKIEDLQRQHQRELEKLRE---EKDRLLAEETAATISAIEAMKNAH 779
Q +K E ++Q +R+ ++LR E + + + +TI+A+EA
Sbjct: 1774 EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1833
Query: 780 REEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLE-NAHLA 838
E++E+E + Q + S D ++ E L V+ E + ++EQY ++ + NA +
Sbjct: 1834 EEQVEQEAREKQAATKSLKQKD-----KKLKEILLQVEDERK-MAEQYKEQAEKGNARVK 1887
Query: 839 QALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKD 898
Q ++ L + + E+Q +NA+ ++L L EAT S A G++
Sbjct: 1888 QL----KRQLEEAEEESQRINANRRKLQREL----------------DEATESNEAMGRE 1927
Query: 899 AYELEVLLR 907
L+ LR
Sbjct: 1928 VNALKSKLR 1936
Score = 41.2 bits (95), Expect = 0.005
Identities = 68/295 (23%), Positives = 126/295 (42%), Gaps = 73/295 (24%)
Query: 719 VLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNA 778
+LQ T + +E +K ++ Q++ + EL++L E+K L EE KN
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKEL-EQKHSQLTEE-----------KNL 898
Query: 779 HREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLA 838
+E+++ E E + ++ E +R + L + ++ELE + + + E
Sbjct: 899 LQEQLQAETE---------LYAEAEEMRVR----LAAKKQELEEILHEMEARLEEEEDRG 945
Query: 839 QALEAERQALRQ----CQRENQELNAHNQEL------------------------NNRLA 870
Q L+AER+ + Q + + +E A Q+L NN+L+
Sbjct: 946 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005
Query: 871 AE----ITRLRTLLTGDGGGEATGSPLAQGKDAY-----ELEVLLRVKESEIQYLKQEIS 921
E R+ L T E L + K+ + ELEV L+ +E +QE+
Sbjct: 1006 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS----RQELE 1061
Query: 922 SLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEALGEK 976
LK +L+ ASD ++ I +L A+ +++ +E+L+AA L ++
Sbjct: 1062 KLKRKLEGD------ASDFHEQI-ADLQAQIAELKMQLAKKEEELQAALARLDDE 1109
Score = 38.9 bits (89), Expect = 0.025
Identities = 75/367 (20%), Positives = 149/367 (40%), Gaps = 40/367 (10%)
Query: 521 EPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGE 580
E D + + + E+RR+ + + ++ + L ER A + L + + E
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEY------ETELEDERKQRALAAAAKKKLEGDLKDLE 1637
Query: 581 LERERA-RRREERRKRFGMLDATDGP---GTEDA-ALRMEVDRSPGLPMSDLKTHNVHVE 635
L+ + A + REE K+ L A EDA A R E+ + ++ K ++ +
Sbjct: 1638 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA--KENEKKAKSLEAD 1695
Query: 636 IEQRWHQVETTPLREEKQVPIAPVHLSSEDGGD---RLSTHELTSLLEKELEQSQKEASD 692
+ Q + R KQ + L+ E R + + LE + Q ++E +
Sbjct: 1696 LMQLQEDLAAAE-RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1754
Query: 693 LLEQNRLLQDQLRVALGR-EQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRE-- 749
+ D++R A + EQ + E ++T ++ +A ++ ++ E + H+ E
Sbjct: 1755 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1814
Query: 750 ---------------LEKLREEKDRLLAEETAATISAIEAMKNAH----REEMERELEKS 790
+ +L E+ ++ E+ AAT S + K + E ER++ +
Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1874
Query: 791 QRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQ 850
+ Q N+ V+ L+RQ LEE + + + + ++ E +A+ E AL+
Sbjct: 1875 YKEQAEKGNARVKQLKRQ-LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1933
Query: 851 CQRENQE 857
R E
Sbjct: 1934 KLRRGNE 1940
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 79.0 bits (193), Expect = 2e-14
Identities = 110/468 (23%), Positives = 205/468 (43%), Gaps = 69/468 (14%)
Query: 527 KRSRARERRREGRSKTFDWAEFRPIQQALAQ----ERVGGVGPADTHEPLRPEAEPG--- 579
+R RA RE +K A R +++AL ER + A+ + + + + G
Sbjct: 1477 ERDRAEAEAREKETKALSLA--RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV 1534
Query: 580 -ELERERARRREERRKRFGMLDATDGP--GTEDAALRMEVDRSP-------GLPMSDLKT 629
ELE+ + + + L+ + TEDA LR+EV+ L D +
Sbjct: 1535 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1594
Query: 630 HNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKE 689
+++++ H+ ET E KQ +A +G LE + + + K
Sbjct: 1595 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD--------LKDLELQADSAIKG 1646
Query: 690 ASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRE 749
+ ++Q R LQ Q++ + AR A+ + FA +E ++KK + L+ +
Sbjct: 1647 REEAIKQLRKLQAQMKDFQRELEDAR------ASRDEIFATAKE-NEKKAKSLEA----D 1695
Query: 750 LEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQ--RSQISSVNSDVEALRR 807
L +L+E+ L A E A + +E +EE+ EL S R+ + +EA
Sbjct: 1696 LMQLQED---LAAAERARKQADLE------KEELAEELASSLSGRNALQDEKRRLEARIA 1746
Query: 808 QYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNN 867
Q EEL+ Q +E +S++ + + L+ L ER ++ + Q+L N+EL +
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806
Query: 868 RL----AAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSL 923
+L A ++ ++ + A + +AQ ++ E E R K++ + LKQ+ L
Sbjct: 1807 KLHEMEGAVKSKFKSTIA------ALEAKIAQLEEQVEQEA--REKQAATKSLKQKDKKL 1858
Query: 924 KDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATE 971
K E+ + D++ +++YK+ K + + +LK QL+ A E
Sbjct: 1859 K-EILLQVEDERKMAEQYKE-------QAEKGNARVKQLKRQLEEAEE 1898
Score = 63.9 bits (154), Expect = 7e-10
Identities = 83/343 (24%), Positives = 153/343 (44%), Gaps = 32/343 (9%)
Query: 656 IAPVHLSSEDGGDRLSTHELT-SLLEKELEQSQKEASDLLEQ---NRLLQDQLRVALGRE 711
I+ +++ D +L T LE+ ++ QKE +L +Q D+L R
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1432
Query: 712 QSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAE----ETAA 767
Q + V+ +R + E Q+K + L + + K +E+DR AE ET A
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492
Query: 768 TISAIEAMKNA--HREEMER--ELEKSQRSQISSVNSDV-------EALRRQYLEELQSV 816
+S A++ A +EE+ER ++ K++ + S DV E +R +++ +
Sbjct: 1493 -LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1551
Query: 817 QRELEVLSEQYSQKCLENAHLAQALEAERQALR-QCQRENQELNAHNQELNNRLAAEITR 875
+ +LE L ++ + E+A L LE QAL+ Q +R+ Q + N+E +L ++
Sbjct: 1552 KTQLEELEDEL--QATEDAKL--RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 876 LRTLLTGDGGGEATGSPLAQ--GKDAYELEV----LLRVKESEIQYLKQEISSLKDELQT 929
T L + A + + D +LE+ ++ +E I+ L++ + +KD Q
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD-FQR 1666
Query: 930 ALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEA 972
L D + + D+ E + D+ +L+E L AA A
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1709
Score = 59.3 bits (142), Expect = 2e-08
Identities = 119/525 (22%), Positives = 218/525 (41%), Gaps = 77/525 (14%)
Query: 514 KQEAELGEPDPEQKRSRARERRR----EGRSKTFDWAEFRPIQQALAQERVGGVGPADTH 569
+Q+AE + EQK S+ E + + +++T +AE ++ LA ++ +
Sbjct: 875 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK------QELE 928
Query: 570 EPLRPEAEPGELERERARRREERRKRFG--MLDATDGPGTEDAAL-RMEVDRSPGLPMSD 626
E L E E +R ++ + RK+ MLD + E+AA ++++++
Sbjct: 929 EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 988
Query: 627 LKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLST----HE-LTSLLEK 681
+ V +Q + L EE+ + E+ L+ HE + S LE
Sbjct: 989 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1048
Query: 682 ELEQSQKEASDLLEQNRLLQD------------QLRVALGREQSAREGYVLQATCER--G 727
L++ +K +L + R L+ Q ++A + Q A++ LQA R
Sbjct: 1049 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD 1108
Query: 728 FAAMEETHQKKIEDLQ---RQHQRELEKLR------EEKDRLLAEETAATISAIEAMKN- 777
A + KKI +L+ Q +L+ R E++ R L EE A + +E +
Sbjct: 1109 EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS 1168
Query: 778 --------AHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVL------ 823
A RE+ L+K+ + S + V+ +R+++ + ++ + +LE
Sbjct: 1169 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN 1228
Query: 824 ---SEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNR----------LA 870
++Q +K ENA LA L QA ++ + + ++L A QEL ++ L
Sbjct: 1229 LDKNKQTLEK--ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN 1286
Query: 871 AEITRLRTLLTGDGG--GEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQ 928
++ +L+ + G EA G + KD L L+ + Q L QE + K +
Sbjct: 1287 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ----DTQELLQEETRQKLNVS 1342
Query: 929 TALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEAL 973
T LR + + +D E AK + IS L QL + + L
Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387
Score = 53.5 bits (127), Expect = 1e-06
Identities = 76/323 (23%), Positives = 139/323 (43%), Gaps = 34/323 (10%)
Query: 672 THELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAM 731
T E E EL++ +++ S L E+ LLQ+QL+ A E V A
Sbjct: 871 TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA--------- 921
Query: 732 EETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQ 791
++++E++ + + LE+ + +L AE ++ E++E E Q
Sbjct: 922 --AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL-----EEQLEEEEAARQ 974
Query: 792 RSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLEN--AHLAQALEAERQALR 849
+ Q+ V + EA ++ +E+ + + LS++ +K LE + L L E + +
Sbjct: 975 KLQLEKVTA--EAKIKKLEDEILVMDDQNNKLSKE--RKLLEERISDLTTNLAEEEEKAK 1030
Query: 850 QCQRENQELNAHNQELNNRL------AAEITRLRTLLTGDGGGEATGSPLAQGKDAYELE 903
+ + + EL RL E+ +L+ L GD Q + A EL+
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA-ELK 1089
Query: 904 VLLRVKESEIQ----YLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDI 959
+ L KE E+Q L EI+ + L+ + + SD +D+ +E + A+ KA+
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA-ARNKAEKQK 1148
Query: 960 SRLKEQLKAATEALGEKSPDSAT 982
L E+L+A L + +AT
Sbjct: 1149 RDLGEELEALKTELEDTLDSTAT 1171
Score = 48.5 bits (114), Expect = 3e-05
Identities = 62/249 (24%), Positives = 115/249 (46%), Gaps = 47/249 (18%)
Query: 679 LEKELEQSQKEASDLLEQNRLLQD----QLRVALGREQSAREGYVLQATCERGFAAMEET 734
LEKE E +++ AS L +N L + + R+A E+ E ++A +R A ++
Sbjct: 1715 LEKE-ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1773
Query: 735 HQ------------KKIEDLQRQHQRELEKLRE---EKDRLLAEETAATISAIEAMKNAH 779
Q +K E ++Q +R+ ++LR E + + + +TI+A+EA
Sbjct: 1774 EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1833
Query: 780 REEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLE-NAHLA 838
E++E+E + Q + S D ++ E L V+ E + ++EQY ++ + NA +
Sbjct: 1834 EEQVEQEAREKQAATKSLKQKD-----KKLKEILLQVEDERK-MAEQYKEQAEKGNARVK 1887
Query: 839 QALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKD 898
Q ++ L + + E+Q +NA+ ++L L EAT S A G++
Sbjct: 1888 QL----KRQLEEAEEESQRINANRRKLQREL----------------DEATESNEAMGRE 1927
Query: 899 AYELEVLLR 907
L+ LR
Sbjct: 1928 VNALKSKLR 1936
Score = 41.2 bits (95), Expect = 0.005
Identities = 68/295 (23%), Positives = 126/295 (42%), Gaps = 73/295 (24%)
Query: 719 VLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNA 778
+LQ T + +E +K ++ Q++ + EL++L E+K L EE KN
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKEL-EQKHSQLTEE-----------KNL 898
Query: 779 HREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLA 838
+E+++ E E + ++ E +R + L + ++ELE + + + E
Sbjct: 899 LQEQLQAETE---------LYAEAEEMRVR----LAAKKQELEEILHEMEARLEEEEDRG 945
Query: 839 QALEAERQALRQ----CQRENQELNAHNQEL------------------------NNRLA 870
Q L+AER+ + Q + + +E A Q+L NN+L+
Sbjct: 946 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005
Query: 871 AE----ITRLRTLLTGDGGGEATGSPLAQGKDAY-----ELEVLLRVKESEIQYLKQEIS 921
E R+ L T E L + K+ + ELEV L+ +E +QE+
Sbjct: 1006 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS----RQELE 1061
Query: 922 SLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEALGEK 976
LK +L+ ASD ++ I +L A+ +++ +E+L+AA L ++
Sbjct: 1062 KLKRKLEGD------ASDFHEQI-ADLQAQIAELKMQLAKKEEELQAALARLDDE 1109
Score = 37.0 bits (84), Expect = 0.095
Identities = 73/359 (20%), Positives = 147/359 (40%), Gaps = 40/359 (11%)
Query: 521 EPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGE 580
E D + + + E+RR+ + + ++ + L ER A + L + + E
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEY------ETELEDERKQRALAAAAKKKLEGDLKDLE 1637
Query: 581 LERERA-RRREERRKRFGMLDATDGP---GTEDA-ALRMEVDRSPGLPMSDLKTHNVHVE 635
L+ + A + REE K+ L A EDA A R E+ + ++ K ++ +
Sbjct: 1638 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA--KENEKKAKSLEAD 1695
Query: 636 IEQRWHQVETTPLREEKQVPIAPVHLSSEDGGD---RLSTHELTSLLEKELEQSQKEASD 692
+ Q + R KQ + L+ E R + + LE + Q ++E +
Sbjct: 1696 LMQLQEDLAAAE-RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1754
Query: 693 LLEQNRLLQDQLRVALGR-EQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRE-- 749
+ D++R A + EQ + E ++T ++ +A ++ ++ E + H+ E
Sbjct: 1755 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1814
Query: 750 ---------------LEKLREEKDRLLAEETAATISAIEAMKNAH----REEMERELEKS 790
+ +L E+ ++ E+ AAT S + K + E ER++ +
Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1874
Query: 791 QRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALR 849
+ Q N+ V+ L+RQ LEE + + + + ++ E +A+ E AL+
Sbjct: 1875 YKEQAEKGNARVKQLKRQ-LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1932
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 79.0 bits (193), Expect = 2e-14
Identities = 110/468 (23%), Positives = 205/468 (43%), Gaps = 69/468 (14%)
Query: 527 KRSRARERRREGRSKTFDWAEFRPIQQALAQ----ERVGGVGPADTHEPLRPEAEPG--- 579
+R RA RE +K A R +++AL ER + A+ + + + + G
Sbjct: 1470 ERDRAEAEAREKETKALSLA--RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV 1527
Query: 580 -ELERERARRREERRKRFGMLDATDGP--GTEDAALRMEVDRSP-------GLPMSDLKT 629
ELE+ + + + L+ + TEDA LR+EV+ L D +
Sbjct: 1528 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1587
Query: 630 HNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKE 689
+++++ H+ ET E KQ +A +G LE + + + K
Sbjct: 1588 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD--------LKDLELQADSAIKG 1639
Query: 690 ASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRE 749
+ ++Q R LQ Q++ + AR A+ + FA +E ++KK + L+ +
Sbjct: 1640 REEAIKQLRKLQAQMKDFQRELEDAR------ASRDEIFATAKE-NEKKAKSLEA----D 1688
Query: 750 LEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQ--RSQISSVNSDVEALRR 807
L +L+E+ L A E A + +E +EE+ EL S R+ + +EA
Sbjct: 1689 LMQLQED---LAAAERARKQADLE------KEELAEELASSLSGRNALQDEKRRLEARIA 1739
Query: 808 QYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNN 867
Q EEL+ Q +E +S++ + + L+ L ER ++ + Q+L N+EL +
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 868 RL----AAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSL 923
+L A ++ ++ + A + +AQ ++ E E R K++ + LKQ+ L
Sbjct: 1800 KLHEMEGAVKSKFKSTIA------ALEAKIAQLEEQVEQEA--REKQAATKSLKQKDKKL 1851
Query: 924 KDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATE 971
K E+ + D++ +++YK+ K + + +LK QL+ A E
Sbjct: 1852 K-EILLQVEDERKMAEQYKE-------QAEKGNARVKQLKRQLEEAEE 1891
Score = 63.9 bits (154), Expect = 7e-10
Identities = 83/343 (24%), Positives = 153/343 (44%), Gaps = 32/343 (9%)
Query: 656 IAPVHLSSEDGGDRLSTHELT-SLLEKELEQSQKEASDLLEQ---NRLLQDQLRVALGRE 711
I+ +++ D +L T LE+ ++ QKE +L +Q D+L R
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1425
Query: 712 QSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAE----ETAA 767
Q + V+ +R + E Q+K + L + + K +E+DR AE ET A
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485
Query: 768 TISAIEAMKNA--HREEMER--ELEKSQRSQISSVNSDV-------EALRRQYLEELQSV 816
+S A++ A +EE+ER ++ K++ + S DV E +R +++ +
Sbjct: 1486 -LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1544
Query: 817 QRELEVLSEQYSQKCLENAHLAQALEAERQALR-QCQRENQELNAHNQELNNRLAAEITR 875
+ +LE L ++ + E+A L LE QAL+ Q +R+ Q + N+E +L ++
Sbjct: 1545 KTQLEELEDEL--QATEDAKL--RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 876 LRTLLTGDGGGEATGSPLAQ--GKDAYELEV----LLRVKESEIQYLKQEISSLKDELQT 929
T L + A + + D +LE+ ++ +E I+ L++ + +KD Q
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD-FQR 1659
Query: 930 ALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEA 972
L D + + D+ E + D+ +L+E L AA A
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1702
Score = 59.3 bits (142), Expect = 2e-08
Identities = 119/525 (22%), Positives = 218/525 (41%), Gaps = 77/525 (14%)
Query: 514 KQEAELGEPDPEQKRSRARERRR----EGRSKTFDWAEFRPIQQALAQERVGGVGPADTH 569
+Q+AE + EQK S+ E + + +++T +AE ++ LA ++ +
Sbjct: 868 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKK------QELE 921
Query: 570 EPLRPEAEPGELERERARRREERRKRFG--MLDATDGPGTEDAAL-RMEVDRSPGLPMSD 626
E L E E +R ++ + RK+ MLD + E+AA ++++++
Sbjct: 922 EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 981
Query: 627 LKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLST----HE-LTSLLEK 681
+ V +Q + L EE+ + E+ L+ HE + S LE
Sbjct: 982 KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1041
Query: 682 ELEQSQKEASDLLEQNRLLQD------------QLRVALGREQSAREGYVLQATCER--G 727
L++ +K +L + R L+ Q ++A + Q A++ LQA R
Sbjct: 1042 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD 1101
Query: 728 FAAMEETHQKKIEDLQ---RQHQRELEKLR------EEKDRLLAEETAATISAIEAMKN- 777
A + KKI +L+ Q +L+ R E++ R L EE A + +E +
Sbjct: 1102 EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS 1161
Query: 778 --------AHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVL------ 823
A RE+ L+K+ + S + V+ +R+++ + ++ + +LE
Sbjct: 1162 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN 1221
Query: 824 ---SEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNR----------LA 870
++Q +K ENA LA L QA ++ + + ++L A QEL ++ L
Sbjct: 1222 LDKNKQTLEK--ENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN 1279
Query: 871 AEITRLRTLLTGDGG--GEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQ 928
++ +L+ + G EA G + KD L L+ + Q L QE + K +
Sbjct: 1280 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQ----DTQELLQEETRQKLNVS 1335
Query: 929 TALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEAL 973
T LR + + +D E AK + IS L QL + + L
Sbjct: 1336 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380
Score = 53.5 bits (127), Expect = 1e-06
Identities = 76/323 (23%), Positives = 139/323 (43%), Gaps = 34/323 (10%)
Query: 672 THELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAM 731
T E E EL++ +++ S L E+ LLQ+QL+ A E V A
Sbjct: 864 TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA--------- 914
Query: 732 EETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQ 791
++++E++ + + LE+ + +L AE ++ E++E E Q
Sbjct: 915 --AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL-----EEQLEEEEAARQ 967
Query: 792 RSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLEN--AHLAQALEAERQALR 849
+ Q+ V + EA ++ +E+ + + LS++ +K LE + L L E + +
Sbjct: 968 KLQLEKVTA--EAKIKKLEDEILVMDDQNNKLSKE--RKLLEERISDLTTNLAEEEEKAK 1023
Query: 850 QCQRENQELNAHNQELNNRL------AAEITRLRTLLTGDGGGEATGSPLAQGKDAYELE 903
+ + + EL RL E+ +L+ L GD Q + A EL+
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA-ELK 1082
Query: 904 VLLRVKESEIQ----YLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDI 959
+ L KE E+Q L EI+ + L+ + + SD +D+ +E + A+ KA+
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA-ARNKAEKQK 1141
Query: 960 SRLKEQLKAATEALGEKSPDSAT 982
L E+L+A L + +AT
Sbjct: 1142 RDLGEELEALKTELEDTLDSTAT 1164
Score = 48.5 bits (114), Expect = 3e-05
Identities = 62/249 (24%), Positives = 115/249 (46%), Gaps = 47/249 (18%)
Query: 679 LEKELEQSQKEASDLLEQNRLLQD----QLRVALGREQSAREGYVLQATCERGFAAMEET 734
LEKE E +++ AS L +N L + + R+A E+ E ++A +R A ++
Sbjct: 1708 LEKE-ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1766
Query: 735 HQ------------KKIEDLQRQHQRELEKLRE---EKDRLLAEETAATISAIEAMKNAH 779
Q +K E ++Q +R+ ++LR E + + + +TI+A+EA
Sbjct: 1767 EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1826
Query: 780 REEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLE-NAHLA 838
E++E+E + Q + S D ++ E L V+ E + ++EQY ++ + NA +
Sbjct: 1827 EEQVEQEAREKQAATKSLKQKD-----KKLKEILLQVEDERK-MAEQYKEQAEKGNARVK 1880
Query: 839 QALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKD 898
Q ++ L + + E+Q +NA+ ++L L EAT S A G++
Sbjct: 1881 QL----KRQLEEAEEESQRINANRRKLQREL----------------DEATESNEAMGRE 1920
Query: 899 AYELEVLLR 907
L+ LR
Sbjct: 1921 VNALKSKLR 1929
Score = 41.2 bits (95), Expect = 0.005
Identities = 68/295 (23%), Positives = 126/295 (42%), Gaps = 73/295 (24%)
Query: 719 VLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNA 778
+LQ T + +E +K ++ Q++ + EL++L E+K L EE KN
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKEL-EQKHSQLTEE-----------KNL 891
Query: 779 HREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLA 838
+E+++ E E + ++ E +R + L + ++ELE + + + E
Sbjct: 892 LQEQLQAETE---------LYAEAEEMRVR----LAAKKQELEEILHEMEARLEEEEDRG 938
Query: 839 QALEAERQALRQ----CQRENQELNAHNQEL------------------------NNRLA 870
Q L+AER+ + Q + + +E A Q+L NN+L+
Sbjct: 939 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998
Query: 871 AE----ITRLRTLLTGDGGGEATGSPLAQGKDAY-----ELEVLLRVKESEIQYLKQEIS 921
E R+ L T E L + K+ + ELEV L+ +E +QE+
Sbjct: 999 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS----RQELE 1054
Query: 922 SLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEALGEK 976
LK +L+ ASD ++ I +L A+ +++ +E+L+AA L ++
Sbjct: 1055 KLKRKLEGD------ASDFHEQI-ADLQAQIAELKMQLAKKEEELQAALARLDDE 1102
Score = 37.0 bits (84), Expect = 0.095
Identities = 73/359 (20%), Positives = 147/359 (40%), Gaps = 40/359 (11%)
Query: 521 EPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGE 580
E D + + + E+RR+ + + ++ + L ER A + L + + E
Sbjct: 1577 ERDLQARDEQNEEKRRQLQRQLHEY------ETELEDERKQRALAAAAKKKLEGDLKDLE 1630
Query: 581 LERERA-RRREERRKRFGMLDATDGP---GTEDA-ALRMEVDRSPGLPMSDLKTHNVHVE 635
L+ + A + REE K+ L A EDA A R E+ + ++ K ++ +
Sbjct: 1631 LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA--KENEKKAKSLEAD 1688
Query: 636 IEQRWHQVETTPLREEKQVPIAPVHLSSEDGGD---RLSTHELTSLLEKELEQSQKEASD 692
+ Q + R KQ + L+ E R + + LE + Q ++E +
Sbjct: 1689 LMQLQEDLAAAE-RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1747
Query: 693 LLEQNRLLQDQLRVALGR-EQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRE-- 749
+ D++R A + EQ + E ++T ++ +A ++ ++ E + H+ E
Sbjct: 1748 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1807
Query: 750 ---------------LEKLREEKDRLLAEETAATISAIEAMKNAH----REEMERELEKS 790
+ +L E+ ++ E+ AAT S + K + E ER++ +
Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1867
Query: 791 QRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALR 849
+ Q N+ V+ L+RQ LEE + + + + ++ E +A+ E AL+
Sbjct: 1868 YKEQAEKGNARVKQLKRQ-LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1925
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 75.5 bits (184), Expect = 2e-13
Identities = 128/514 (24%), Positives = 210/514 (40%), Gaps = 79/514 (15%)
Query: 510 RPTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQAL-AQERVGGVGPADT 568
R +++ +L + + +++AR+ RS+ E R ++ L A ER G G
Sbjct: 1416 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG-GAEGE 1474
Query: 569 HEPLRPEAEPGELERERARRREER----------RKRFGMLDATDGPGTEDAALRMEVDR 618
+ LR AE E ++ +A+ ER RKR ++ E A R +
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1534
Query: 619 SPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDG--GDRLSTHELT 676
L L+ E E+R Q E R+ QV + S+E R S E T
Sbjct: 1535 LQALEELRLQAE----EAERRLRQAEVERARQV-QVALETAQRSAEAELQSKRASFAEKT 1589
Query: 677 SLLEKEL------------------------EQSQKEASDLLEQNRLLQDQ-LRVALGRE 711
+ LE+ L E++++EA LE+ +L ++ LR+ L E
Sbjct: 1590 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649
Query: 712 QSAREGYVLQATCERGFAAME-ETHQKKIEDLQRQHQRELEKLREEKDRLLAEETA---- 766
+ A++ + QA E+ E E ++ + Q QREL + EK R LAE TA
Sbjct: 1650 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1709
Query: 767 -ATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVL-- 823
A I + E +R+L + + +++ + R++ EL V+ E+EVL
Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1769
Query: 824 ----SEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTL 879
+E+ S+ E + Q LEAE R+ E L A LA E R R L
Sbjct: 1770 SKARAEEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRA--------LAEEAKRQRQL 1819
Query: 880 LTGDGGGEATGSP--LAQGKDAY--------ELEVLLRVKESEIQYLKQEISSLKDELQT 929
D + + LA+ A E E+ L+ KE+E + L++ +DE
Sbjct: 1820 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR---LAEDEAFQ 1876
Query: 930 ALRDKKYASDKYKDIYTELSIAKAKADCDISRLK 963
R ++ A+ DI L+ + +D ++ R K
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1910
Score = 72.4 bits (176), Expect = 2e-12
Identities = 134/612 (21%), Positives = 251/612 (41%), Gaps = 107/612 (17%)
Query: 496 EEKNKSSCSFETCPRPTEKQEAELGE-----PDPEQKRSRARERRREGRSKTFDWAEFRP 550
EE+++S T + ++ EAE G + + R+ A E +R+ + D A R
Sbjct: 1775 EEESRS-----TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1829
Query: 551 IQQALAQERVGGVGPADTHEPLRPEAEPG----ELERERARRREE----RRKRFGMLDAT 602
+ + E++ +G A L+ EAE E E ER RR E +R+R A
Sbjct: 1830 EAERVLAEKLAAIGEATR---LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1886
Query: 603 DGPGTEDAALRM------EVDRSPGLPMSDLKTHN-VHVEIEQRWHQVETTPL-REEKQV 654
E+ ++ E++R GL L+ V EI E + E ++
Sbjct: 1887 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1946
Query: 655 PIAPVHLSSEDGGDRLSTHELTSLLEKEL----EQSQKEASDLLEQNRLLQD----QLRV 706
+ + ++ED EL + +++L E+ ++EA + ++++ ++ Q +
Sbjct: 1947 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006
Query: 707 AL-------------------GREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQ 747
AL ++SAR+ + Q ++ A E+ H ++ +++ Q
Sbjct: 2007 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066
Query: 748 RELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRR 807
+ L++ + D+L E AA +A EA + R + ERE +S+R + E L++
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEA--RVQAEREAAQSRRQV-----EEAERLKQ 2119
Query: 808 QYLEELQS---VQRELEVLSEQYSQKCLENAHLAQALEAERQA---------------LR 849
E+ Q+ Q E L ++ Q+ A QA ++QA LR
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2179
Query: 850 QCQRENQELNAHNQEL------NNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELE 903
Q + QEL +L N L E+ RL+ EAT + + + EL
Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK--------AEATEAARQRSQVEEEL- 2230
Query: 904 VLLRVKESEIQYLKQEISSL--------KDELQTALRDKKYASDKYKDIYTELSIAKAKA 955
+RV+ E+ LK I + KD Q L+++ + + LS+A +A
Sbjct: 2231 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2290
Query: 956 DCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIR-- 1013
+ +L E+ A AL EK + + + K+ + L++ + Q R ++
Sbjct: 2291 -ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2349
Query: 1014 SKSVIEQVSWDT 1025
+ + +Q++ +T
Sbjct: 2350 KEQMAQQLAEET 2361
Score = 54.7 bits (130), Expect = 4e-07
Identities = 104/472 (22%), Positives = 195/472 (41%), Gaps = 78/472 (16%)
Query: 573 RPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNV 632
R A+P + ARRR+E+ + + D+ A+R ++ + L + +++ H
Sbjct: 1213 RESADPLGAWLQDARRRQEQIQAMPLADSQ--------AVREQLRQEQAL-LEEIERHGE 1263
Query: 633 HVEIEQRW----------HQVETTPLREEKQVPIAPVHLSSEDGGDR--------LSTH- 673
VE QR+ ++++ + + + +P G L TH
Sbjct: 1264 KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY 1323
Query: 674 -ELTSLLEKELEQSQKEASDLLEQNRLLQDQ----------LRVALGREQSAREGYV-LQ 721
ELT+L + ++ + + E+ RL + Q + AL +++ E + +
Sbjct: 1324 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1383
Query: 722 ATCERGFAAMEETHQKKI----------EDLQRQHQRELEKLREEKDRLLAEETAATISA 771
A ER +++ Q+++ + +R Q EL++LR+ + AE A A
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AEIQAKARQA 1440
Query: 772 IEAMKNAHREEME-----RELEKSQRSQISSVNSDVEALRRQYLE---ELQSVQRELEVL 823
A ++ R E E +LE ++R Q +++ALR + E + + Q E E L
Sbjct: 1441 EAAERSRLRIEEEIRVVRLQLEATER-QRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1499
Query: 824 SEQY----SQKCLENAHLAQALEAERQALRQCQRENQ---ELNAHNQELNNRL-AAEITR 875
Q +K LA ++AE +A R+ QR Q EL +E RL AE+ R
Sbjct: 1500 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1559
Query: 876 LRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKK 935
R + + + Q K A E +++ S +Q ++ L++E + + +
Sbjct: 1560 ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS-LQEEHVAVAQLREEAERRAQQQA 1618
Query: 936 YASDKYKDIYTELSIAKAKADCDISRLK------EQLKAATEALGEKSPDSA 981
A ++ EL + KA+ + RL+ Q K+ +A EK + A
Sbjct: 1619 EAERAREEAERELERWQLKAN-EALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1669
Score = 51.6 bits (122), Expect = 4e-06
Identities = 102/476 (21%), Positives = 183/476 (38%), Gaps = 63/476 (13%)
Query: 513 EKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPL 572
E + A + E+ R +A + R + + + + AQ R A E L
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKL 2138
Query: 573 RPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTH-- 630
R EAE R +A + R+K+ + + LR + L L+
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198
Query: 631 ----NVHVEIEQRWHQVETTPLREEKQVP--IAPVHLSSEDGGDRLSTHELTS------- 677
N+ E QR T R+ QV + V + E+ + E +
Sbjct: 2199 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2258
Query: 678 ------LLEKELEQSQKEASDLLEQNRLLQDQLRVA-LGREQSAREGYVLQATCERGFAA 730
L++E E+ ++ A + + Q+ R+ L E A++ + + + A
Sbjct: 2259 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2318
Query: 731 MEETHQKKIEDLQRQHQREL-----EKLREEKDRL---LAEETAATISAIEAMKNAHREE 782
++E + K E Q Q+EL +L+E+K+++ LAEET +EA E
Sbjct: 2319 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA-------E 2371
Query: 783 MERELEKSQRSQISSVN-SDVEALRRQYLEELQSVQRELEVLSEQYSQKCL---ENAHLA 838
+R+LE S ++ + +++ + + E+ Q +++ E + E+ + L E L
Sbjct: 2372 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2431
Query: 839 QALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKD 898
Q LE +RQ + H+ E AE+ R + L + + L Q K
Sbjct: 2432 QTLEIQRQQ-----------SDHDAERLREAIAELEREKEKLQQE-------AKLLQLKS 2473
Query: 899 AYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAK 954
V E Q L+Q S KD L R + K + ++ + +AKA+
Sbjct: 2474 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD-EVAKAQ 2528
Score = 50.1 bits (118), Expect = 1e-05
Identities = 87/360 (24%), Positives = 157/360 (43%), Gaps = 58/360 (16%)
Query: 531 ARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAE----PGELERERA 586
A+E R + D A+ R + + + +E++ V A L+ EAE EL +E+A
Sbjct: 2287 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR---LKAEAELLQQQKELAQEQA 2343
Query: 587 RRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMS-DLKTHNVHV-EIEQRWHQVE 644
RR +E +++ A + G + +E +R L MS + + + V E+ + + E
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRT---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2400
Query: 645 TTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQS---QKEASDLLEQNRLLQ 701
R KQ +E+ G++L EL + + L Q+ Q++ SD + RL +
Sbjct: 2401 EDAQRFRKQ---------AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLRE 2450
Query: 702 DQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLL 761
+ +E+ +E +LQ E M+ Q E L ++ Q + EKD LL
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSEE----MQTVQQ---EQLLQETQALQQSFLSEKDSLL 2503
Query: 762 AEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELE 821
+ ER +E+ +++++ + D A +Q EE Q Q+++E
Sbjct: 2504 --------------------QRERFIEQ-EKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542
Query: 822 VLSEQYSQKCLENAHLAQALEAE-RQALRQCQRENQELNAHNQELNNRLAAEITRLRTLL 880
Q Q+ + + A+ + E + +R+ Q E Q+L ++ LA E RLR L
Sbjct: 2543 ----QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2598
Score = 49.3 bits (116), Expect = 2e-05
Identities = 89/356 (25%), Positives = 152/356 (42%), Gaps = 30/356 (8%)
Query: 514 KQEAELGEPDPEQKRSRARERRREGRSKTFDWAE-FRPIQQALAQERVGGVGPADTHEPL 572
K EAEL + E + +AR + + AE + Q+ L ER + + E L
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385
Query: 573 RPEAEPGELERERARRREERRK------RFG-MLDATDGPGTEDAAL--RMEVDRSPGLP 623
+ E+ R +AR E+ ++ G L T+ E L +E+ R
Sbjct: 2386 KLRV--AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443
Query: 624 MSD-LKTHNVHVEIEQRWHQVETTPLR---EEKQVPIAPVHLSSEDGGDRLSTHELTSLL 679
++ L+ +E E+ Q E L+ EE Q L + E SLL
Sbjct: 2444 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2503
Query: 680 EKELEQSQKEASDLLEQNRLLQDQLRVALG-REQSAREGYVLQATCERGFAAMEETH--Q 736
++E Q++A LEQ L QD++ A RE+ R+ ++ +R A+MEE Q
Sbjct: 2504 QRERFIEQEKAK--LEQ--LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2559
Query: 737 KKIEDLQRQHQRELEKL---REEKDRLLAEETAATISAIEAMKNAHREEM--ERELEKSQ 791
+ E+ R+ Q EL++L R +++ LLAEE ++ ++ HR + E+ SQ
Sbjct: 2560 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619
Query: 792 RSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQA 847
+ ++ + +AL E + + L + S + L+ A + A E +R A
Sbjct: 2620 VAATKTLPNGRDALDGPAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2673
Score = 47.4 bits (111), Expect = 7e-05
Identities = 63/316 (19%), Positives = 138/316 (43%), Gaps = 30/316 (9%)
Query: 676 TSLLEKELEQS------QKEASD----LLEQNRLLQDQLR-VALGREQSAREGYVLQATC 724
T + ++ELEQ +E++D L+ R Q+Q++ + L Q+ RE Q
Sbjct: 1195 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE----QLRQ 1250
Query: 725 ERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEME 784
E+ E H +K+E+ QR ++ + +++ + +L+ + A A K + E
Sbjct: 1251 EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1310
Query: 785 RELEKSQRSQISSVNSDVEALRRQYL----EELQSVQRELEVLSEQYSQKCLENAHLAQA 840
++ + + + S++ L QY+ E L+ ++ E + +Q +++ A + A
Sbjct: 1311 SVIQ--EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAA 1368
Query: 841 LEAERQALRQCQRENQELNAHNQELNNRLAAEITRL-RTLLTGDGGGEATGSPLAQGKDA 899
LE +RQ + + +EL R+ E+ R + + L Q + +
Sbjct: 1369 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1428
Query: 900 YELEVLLRVKESEIQ-----YLKQEISSLKDELQTALRDKKYASDKYKDIYT---ELSIA 951
E E+ + +++E +++EI ++ +L+ R + A + + + E
Sbjct: 1429 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1488
Query: 952 KAKADCDISRLKEQLK 967
K +A + RL+ Q++
Sbjct: 1489 KRQAQEEAERLRRQVQ 1504
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 75.5 bits (184), Expect = 2e-13
Identities = 128/514 (24%), Positives = 210/514 (40%), Gaps = 79/514 (15%)
Query: 510 RPTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQAL-AQERVGGVGPADT 568
R +++ +L + + +++AR+ RS+ E R ++ L A ER G G
Sbjct: 1420 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG-GAEGE 1478
Query: 569 HEPLRPEAEPGELERERARRREER----------RKRFGMLDATDGPGTEDAALRMEVDR 618
+ LR AE E ++ +A+ ER RKR ++ E A R +
Sbjct: 1479 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1538
Query: 619 SPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDG--GDRLSTHELT 676
L L+ E E+R Q E R+ QV + S+E R S E T
Sbjct: 1539 LQALEELRLQAE----EAERRLRQAEVERARQV-QVALETAQRSAEAELQSKRASFAEKT 1593
Query: 677 SLLEKEL------------------------EQSQKEASDLLEQNRLLQDQ-LRVALGRE 711
+ LE+ L E++++EA LE+ +L ++ LR+ L E
Sbjct: 1594 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1653
Query: 712 QSAREGYVLQATCERGFAAME-ETHQKKIEDLQRQHQRELEKLREEKDRLLAEETA---- 766
+ A++ + QA E+ E E ++ + Q QREL + EK R LAE TA
Sbjct: 1654 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1713
Query: 767 -ATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVL-- 823
A I + E +R+L + + +++ + R++ EL V+ E+EVL
Sbjct: 1714 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1773
Query: 824 ----SEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTL 879
+E+ S+ E + Q LEAE R+ E L A LA E R R L
Sbjct: 1774 SKARAEEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRA--------LAEEAKRQRQL 1823
Query: 880 LTGDGGGEATGSP--LAQGKDAY--------ELEVLLRVKESEIQYLKQEISSLKDELQT 929
D + + LA+ A E E+ L+ KE+E + L++ +DE
Sbjct: 1824 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR---LAEDEAFQ 1880
Query: 930 ALRDKKYASDKYKDIYTELSIAKAKADCDISRLK 963
R ++ A+ DI L+ + +D ++ R K
Sbjct: 1881 RRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1914
Score = 72.4 bits (176), Expect = 2e-12
Identities = 134/612 (21%), Positives = 251/612 (41%), Gaps = 107/612 (17%)
Query: 496 EEKNKSSCSFETCPRPTEKQEAELGE-----PDPEQKRSRARERRREGRSKTFDWAEFRP 550
EE+++S T + ++ EAE G + + R+ A E +R+ + D A R
Sbjct: 1779 EEESRS-----TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1833
Query: 551 IQQALAQERVGGVGPADTHEPLRPEAEPG----ELERERARRREE----RRKRFGMLDAT 602
+ + E++ +G A L+ EAE E E ER RR E +R+R A
Sbjct: 1834 EAERVLAEKLAAIGEATR---LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1890
Query: 603 DGPGTEDAALRM------EVDRSPGLPMSDLKTHN-VHVEIEQRWHQVETTPL-REEKQV 654
E+ ++ E++R GL L+ V EI E + E ++
Sbjct: 1891 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1950
Query: 655 PIAPVHLSSEDGGDRLSTHELTSLLEKEL----EQSQKEASDLLEQNRLLQD----QLRV 706
+ + ++ED EL + +++L E+ ++EA + ++++ ++ Q +
Sbjct: 1951 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2010
Query: 707 AL-------------------GREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQ 747
AL ++SAR+ + Q ++ A E+ H ++ +++ Q
Sbjct: 2011 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2070
Query: 748 RELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRR 807
+ L++ + D+L E AA +A EA + R + ERE +S+R + E L++
Sbjct: 2071 QTLQQEQSVLDQLRGEAEAARRAAEEAEEA--RVQAEREAAQSRRQV-----EEAERLKQ 2123
Query: 808 QYLEELQS---VQRELEVLSEQYSQKCLENAHLAQALEAERQA---------------LR 849
E+ Q+ Q E L ++ Q+ A QA ++QA LR
Sbjct: 2124 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2183
Query: 850 QCQRENQELNAHNQEL------NNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELE 903
Q + QEL +L N L E+ RL+ EAT + + + EL
Sbjct: 2184 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK--------AEATEAARQRSQVEEEL- 2234
Query: 904 VLLRVKESEIQYLKQEISSL--------KDELQTALRDKKYASDKYKDIYTELSIAKAKA 955
+RV+ E+ LK I + KD Q L+++ + + LS+A +A
Sbjct: 2235 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2294
Query: 956 DCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIR-- 1013
+ +L E+ A AL EK + + + K+ + L++ + Q R ++
Sbjct: 2295 -ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2353
Query: 1014 SKSVIEQVSWDT 1025
+ + +Q++ +T
Sbjct: 2354 KEQMAQQLAEET 2365
Score = 54.7 bits (130), Expect = 4e-07
Identities = 104/472 (22%), Positives = 195/472 (41%), Gaps = 78/472 (16%)
Query: 573 RPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNV 632
R A+P + ARRR+E+ + + D+ A+R ++ + L + +++ H
Sbjct: 1217 RESADPLGAWLQDARRRQEQIQAMPLADSQ--------AVREQLRQEQAL-LEEIERHGE 1267
Query: 633 HVEIEQRW----------HQVETTPLREEKQVPIAPVHLSSEDGGDR--------LSTH- 673
VE QR+ ++++ + + + +P G L TH
Sbjct: 1268 KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY 1327
Query: 674 -ELTSLLEKELEQSQKEASDLLEQNRLLQDQ----------LRVALGREQSAREGYV-LQ 721
ELT+L + ++ + + E+ RL + Q + AL +++ E + +
Sbjct: 1328 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1387
Query: 722 ATCERGFAAMEETHQKKI----------EDLQRQHQRELEKLREEKDRLLAEETAATISA 771
A ER +++ Q+++ + +R Q EL++LR+ + AE A A
Sbjct: 1388 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AEIQAKARQA 1444
Query: 772 IEAMKNAHREEME-----RELEKSQRSQISSVNSDVEALRRQYLE---ELQSVQRELEVL 823
A ++ R E E +LE ++R Q +++ALR + E + + Q E E L
Sbjct: 1445 EAAERSRLRIEEEIRVVRLQLEATER-QRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1503
Query: 824 SEQY----SQKCLENAHLAQALEAERQALRQCQRENQ---ELNAHNQELNNRL-AAEITR 875
Q +K LA ++AE +A R+ QR Q EL +E RL AE+ R
Sbjct: 1504 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1563
Query: 876 LRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKK 935
R + + + Q K A E +++ S +Q ++ L++E + + +
Sbjct: 1564 ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS-LQEEHVAVAQLREEAERRAQQQA 1622
Query: 936 YASDKYKDIYTELSIAKAKADCDISRLK------EQLKAATEALGEKSPDSA 981
A ++ EL + KA+ + RL+ Q K+ +A EK + A
Sbjct: 1623 EAERAREEAERELERWQLKAN-EALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1673
Score = 51.6 bits (122), Expect = 4e-06
Identities = 102/476 (21%), Positives = 183/476 (38%), Gaps = 63/476 (13%)
Query: 513 EKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPL 572
E + A + E+ R +A + R + + + + AQ R A E L
Sbjct: 2086 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKL 2142
Query: 573 RPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTH-- 630
R EAE R +A + R+K+ + + LR + L L+
Sbjct: 2143 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2202
Query: 631 ----NVHVEIEQRWHQVETTPLREEKQVP--IAPVHLSSEDGGDRLSTHELTS------- 677
N+ E QR T R+ QV + V + E+ + E +
Sbjct: 2203 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2262
Query: 678 ------LLEKELEQSQKEASDLLEQNRLLQDQLRVA-LGREQSAREGYVLQATCERGFAA 730
L++E E+ ++ A + + Q+ R+ L E A++ + + + A
Sbjct: 2263 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2322
Query: 731 MEETHQKKIEDLQRQHQREL-----EKLREEKDRL---LAEETAATISAIEAMKNAHREE 782
++E + K E Q Q+EL +L+E+K+++ LAEET +EA E
Sbjct: 2323 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA-------E 2375
Query: 783 MERELEKSQRSQISSVN-SDVEALRRQYLEELQSVQRELEVLSEQYSQKCL---ENAHLA 838
+R+LE S ++ + +++ + + E+ Q +++ E + E+ + L E L
Sbjct: 2376 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2435
Query: 839 QALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKD 898
Q LE +RQ + H+ E AE+ R + L + + L Q K
Sbjct: 2436 QTLEIQRQQ-----------SDHDAERLREAIAELEREKEKLQQE-------AKLLQLKS 2477
Query: 899 AYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAK 954
V E Q L+Q S KD L R + K + ++ + +AKA+
Sbjct: 2478 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD-EVAKAQ 2532
Score = 50.1 bits (118), Expect = 1e-05
Identities = 87/360 (24%), Positives = 157/360 (43%), Gaps = 58/360 (16%)
Query: 531 ARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAE----PGELERERA 586
A+E R + D A+ R + + + +E++ V A L+ EAE EL +E+A
Sbjct: 2291 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR---LKAEAELLQQQKELAQEQA 2347
Query: 587 RRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMS-DLKTHNVHV-EIEQRWHQVE 644
RR +E +++ A + G + +E +R L MS + + + V E+ + + E
Sbjct: 2348 RRLQEDKEQMAQQLAEETQGFQRT---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2404
Query: 645 TTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQS---QKEASDLLEQNRLLQ 701
R KQ +E+ G++L EL + + L Q+ Q++ SD + RL +
Sbjct: 2405 EDAQRFRKQ---------AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLRE 2454
Query: 702 DQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLL 761
+ +E+ +E +LQ E M+ Q E L ++ Q + EKD LL
Sbjct: 2455 AIAELEREKEKLQQEAKLLQLKSEE----MQTVQQ---EQLLQETQALQQSFLSEKDSLL 2507
Query: 762 AEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELE 821
+ ER +E+ +++++ + D A +Q EE Q Q+++E
Sbjct: 2508 --------------------QRERFIEQ-EKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2546
Query: 822 VLSEQYSQKCLENAHLAQALEAE-RQALRQCQRENQELNAHNQELNNRLAAEITRLRTLL 880
Q Q+ + + A+ + E + +R+ Q E Q+L ++ LA E RLR L
Sbjct: 2547 ----QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2602
Score = 49.3 bits (116), Expect = 2e-05
Identities = 89/356 (25%), Positives = 152/356 (42%), Gaps = 30/356 (8%)
Query: 514 KQEAELGEPDPEQKRSRARERRREGRSKTFDWAE-FRPIQQALAQERVGGVGPADTHEPL 572
K EAEL + E + +AR + + AE + Q+ L ER + + E L
Sbjct: 2330 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2389
Query: 573 RPEAEPGELERERARRREERRK------RFG-MLDATDGPGTEDAAL--RMEVDRSPGLP 623
+ E+ R +AR E+ ++ G L T+ E L +E+ R
Sbjct: 2390 KLRV--AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2447
Query: 624 MSD-LKTHNVHVEIEQRWHQVETTPLR---EEKQVPIAPVHLSSEDGGDRLSTHELTSLL 679
++ L+ +E E+ Q E L+ EE Q L + E SLL
Sbjct: 2448 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2507
Query: 680 EKELEQSQKEASDLLEQNRLLQDQLRVALG-REQSAREGYVLQATCERGFAAMEETH--Q 736
++E Q++A LEQ L QD++ A RE+ R+ ++ +R A+MEE Q
Sbjct: 2508 QRERFIEQEKAK--LEQ--LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2563
Query: 737 KKIEDLQRQHQRELEKL---REEKDRLLAEETAATISAIEAMKNAHREEM--ERELEKSQ 791
+ E+ R+ Q EL++L R +++ LLAEE ++ ++ HR + E+ SQ
Sbjct: 2564 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2623
Query: 792 RSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQA 847
+ ++ + +AL E + + L + S + L+ A + A E +R A
Sbjct: 2624 VAATKTLPNGRDALDGPAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2677
Score = 47.4 bits (111), Expect = 7e-05
Identities = 63/316 (19%), Positives = 138/316 (43%), Gaps = 30/316 (9%)
Query: 676 TSLLEKELEQS------QKEASD----LLEQNRLLQDQLR-VALGREQSAREGYVLQATC 724
T + ++ELEQ +E++D L+ R Q+Q++ + L Q+ RE Q
Sbjct: 1199 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE----QLRQ 1254
Query: 725 ERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEME 784
E+ E H +K+E+ QR ++ + +++ + +L+ + A A K + E
Sbjct: 1255 EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1314
Query: 785 RELEKSQRSQISSVNSDVEALRRQYL----EELQSVQRELEVLSEQYSQKCLENAHLAQA 840
++ + + + S++ L QY+ E L+ ++ E + +Q +++ A + A
Sbjct: 1315 SVIQ--EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAA 1372
Query: 841 LEAERQALRQCQRENQELNAHNQELNNRLAAEITRL-RTLLTGDGGGEATGSPLAQGKDA 899
LE +RQ + + +EL R+ E+ R + + L Q + +
Sbjct: 1373 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1432
Query: 900 YELEVLLRVKESEIQ-----YLKQEISSLKDELQTALRDKKYASDKYKDIYT---ELSIA 951
E E+ + +++E +++EI ++ +L+ R + A + + + E
Sbjct: 1433 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1492
Query: 952 KAKADCDISRLKEQLK 967
K +A + RL+ Q++
Sbjct: 1493 KRQAQEEAERLRRQVQ 1508
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 75.5 bits (184), Expect = 2e-13
Identities = 128/514 (24%), Positives = 210/514 (40%), Gaps = 79/514 (15%)
Query: 510 RPTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQAL-AQERVGGVGPADT 568
R +++ +L + + +++AR+ RS+ E R ++ L A ER G G
Sbjct: 1416 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG-GAEGE 1474
Query: 569 HEPLRPEAEPGELERERARRREER----------RKRFGMLDATDGPGTEDAALRMEVDR 618
+ LR AE E ++ +A+ ER RKR ++ E A R +
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1534
Query: 619 SPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDG--GDRLSTHELT 676
L L+ E E+R Q E R+ QV + S+E R S E T
Sbjct: 1535 LQALEELRLQAE----EAERRLRQAEVERARQV-QVALETAQRSAEAELQSKRASFAEKT 1589
Query: 677 SLLEKEL------------------------EQSQKEASDLLEQNRLLQDQ-LRVALGRE 711
+ LE+ L E++++EA LE+ +L ++ LR+ L E
Sbjct: 1590 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649
Query: 712 QSAREGYVLQATCERGFAAME-ETHQKKIEDLQRQHQRELEKLREEKDRLLAEETA---- 766
+ A++ + QA E+ E E ++ + Q QREL + EK R LAE TA
Sbjct: 1650 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1709
Query: 767 -ATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVL-- 823
A I + E +R+L + + +++ + R++ EL V+ E+EVL
Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1769
Query: 824 ----SEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTL 879
+E+ S+ E + Q LEAE R+ E L A LA E R R L
Sbjct: 1770 SKARAEEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRA--------LAEEAKRQRQL 1819
Query: 880 LTGDGGGEATGSP--LAQGKDAY--------ELEVLLRVKESEIQYLKQEISSLKDELQT 929
D + + LA+ A E E+ L+ KE+E + L++ +DE
Sbjct: 1820 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR---LAEDEAFQ 1876
Query: 930 ALRDKKYASDKYKDIYTELSIAKAKADCDISRLK 963
R ++ A+ DI L+ + +D ++ R K
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1910
Score = 72.4 bits (176), Expect = 2e-12
Identities = 134/612 (21%), Positives = 251/612 (41%), Gaps = 107/612 (17%)
Query: 496 EEKNKSSCSFETCPRPTEKQEAELGE-----PDPEQKRSRARERRREGRSKTFDWAEFRP 550
EE+++S T + ++ EAE G + + R+ A E +R+ + D A R
Sbjct: 1775 EEESRS-----TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1829
Query: 551 IQQALAQERVGGVGPADTHEPLRPEAEPG----ELERERARRREE----RRKRFGMLDAT 602
+ + E++ +G A L+ EAE E E ER RR E +R+R A
Sbjct: 1830 EAERVLAEKLAAIGEATR---LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1886
Query: 603 DGPGTEDAALRM------EVDRSPGLPMSDLKTHN-VHVEIEQRWHQVETTPL-REEKQV 654
E+ ++ E++R GL L+ V EI E + E ++
Sbjct: 1887 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1946
Query: 655 PIAPVHLSSEDGGDRLSTHELTSLLEKEL----EQSQKEASDLLEQNRLLQD----QLRV 706
+ + ++ED EL + +++L E+ ++EA + ++++ ++ Q +
Sbjct: 1947 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006
Query: 707 AL-------------------GREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQ 747
AL ++SAR+ + Q ++ A E+ H ++ +++ Q
Sbjct: 2007 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066
Query: 748 RELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRR 807
+ L++ + D+L E AA +A EA + R + ERE +S+R + E L++
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEA--RVQAEREAAQSRRQV-----EEAERLKQ 2119
Query: 808 QYLEELQS---VQRELEVLSEQYSQKCLENAHLAQALEAERQA---------------LR 849
E+ Q+ Q E L ++ Q+ A QA ++QA LR
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2179
Query: 850 QCQRENQELNAHNQEL------NNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELE 903
Q + QEL +L N L E+ RL+ EAT + + + EL
Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK--------AEATEAARQRSQVEEEL- 2230
Query: 904 VLLRVKESEIQYLKQEISSL--------KDELQTALRDKKYASDKYKDIYTELSIAKAKA 955
+RV+ E+ LK I + KD Q L+++ + + LS+A +A
Sbjct: 2231 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2290
Query: 956 DCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIR-- 1013
+ +L E+ A AL EK + + + K+ + L++ + Q R ++
Sbjct: 2291 -ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2349
Query: 1014 SKSVIEQVSWDT 1025
+ + +Q++ +T
Sbjct: 2350 KEQMAQQLAEET 2361
Score = 54.7 bits (130), Expect = 4e-07
Identities = 104/472 (22%), Positives = 195/472 (41%), Gaps = 78/472 (16%)
Query: 573 RPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNV 632
R A+P + ARRR+E+ + + D+ A+R ++ + L + +++ H
Sbjct: 1213 RESADPLGAWLQDARRRQEQIQAMPLADSQ--------AVREQLRQEQAL-LEEIERHGE 1263
Query: 633 HVEIEQRW----------HQVETTPLREEKQVPIAPVHLSSEDGGDR--------LSTH- 673
VE QR+ ++++ + + + +P G L TH
Sbjct: 1264 KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY 1323
Query: 674 -ELTSLLEKELEQSQKEASDLLEQNRLLQDQ----------LRVALGREQSAREGYV-LQ 721
ELT+L + ++ + + E+ RL + Q + AL +++ E + +
Sbjct: 1324 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1383
Query: 722 ATCERGFAAMEETHQKKI----------EDLQRQHQRELEKLREEKDRLLAEETAATISA 771
A ER +++ Q+++ + +R Q EL++LR+ + AE A A
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AEIQAKARQA 1440
Query: 772 IEAMKNAHREEME-----RELEKSQRSQISSVNSDVEALRRQYLE---ELQSVQRELEVL 823
A ++ R E E +LE ++R Q +++ALR + E + + Q E E L
Sbjct: 1441 EAAERSRLRIEEEIRVVRLQLEATER-QRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1499
Query: 824 SEQY----SQKCLENAHLAQALEAERQALRQCQRENQ---ELNAHNQELNNRL-AAEITR 875
Q +K LA ++AE +A R+ QR Q EL +E RL AE+ R
Sbjct: 1500 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1559
Query: 876 LRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKK 935
R + + + Q K A E +++ S +Q ++ L++E + + +
Sbjct: 1560 ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS-LQEEHVAVAQLREEAERRAQQQA 1618
Query: 936 YASDKYKDIYTELSIAKAKADCDISRLK------EQLKAATEALGEKSPDSA 981
A ++ EL + KA+ + RL+ Q K+ +A EK + A
Sbjct: 1619 EAERAREEAERELERWQLKAN-EALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1669
Score = 51.6 bits (122), Expect = 4e-06
Identities = 102/476 (21%), Positives = 183/476 (38%), Gaps = 63/476 (13%)
Query: 513 EKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPL 572
E + A + E+ R +A + R + + + + AQ R A E L
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKL 2138
Query: 573 RPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTH-- 630
R EAE R +A + R+K+ + + LR + L L+
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198
Query: 631 ----NVHVEIEQRWHQVETTPLREEKQVP--IAPVHLSSEDGGDRLSTHELTS------- 677
N+ E QR T R+ QV + V + E+ + E +
Sbjct: 2199 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2258
Query: 678 ------LLEKELEQSQKEASDLLEQNRLLQDQLRVA-LGREQSAREGYVLQATCERGFAA 730
L++E E+ ++ A + + Q+ R+ L E A++ + + + A
Sbjct: 2259 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2318
Query: 731 MEETHQKKIEDLQRQHQREL-----EKLREEKDRL---LAEETAATISAIEAMKNAHREE 782
++E + K E Q Q+EL +L+E+K+++ LAEET +EA E
Sbjct: 2319 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA-------E 2371
Query: 783 MERELEKSQRSQISSVN-SDVEALRRQYLEELQSVQRELEVLSEQYSQKCL---ENAHLA 838
+R+LE S ++ + +++ + + E+ Q +++ E + E+ + L E L
Sbjct: 2372 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2431
Query: 839 QALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKD 898
Q LE +RQ + H+ E AE+ R + L + + L Q K
Sbjct: 2432 QTLEIQRQQ-----------SDHDAERLREAIAELEREKEKLQQE-------AKLLQLKS 2473
Query: 899 AYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAK 954
V E Q L+Q S KD L R + K + ++ + +AKA+
Sbjct: 2474 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD-EVAKAQ 2528
Score = 50.1 bits (118), Expect = 1e-05
Identities = 87/360 (24%), Positives = 157/360 (43%), Gaps = 58/360 (16%)
Query: 531 ARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAE----PGELERERA 586
A+E R + D A+ R + + + +E++ V A L+ EAE EL +E+A
Sbjct: 2287 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR---LKAEAELLQQQKELAQEQA 2343
Query: 587 RRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMS-DLKTHNVHV-EIEQRWHQVE 644
RR +E +++ A + G + +E +R L MS + + + V E+ + + E
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRT---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2400
Query: 645 TTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQS---QKEASDLLEQNRLLQ 701
R KQ +E+ G++L EL + + L Q+ Q++ SD + RL +
Sbjct: 2401 EDAQRFRKQ---------AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLRE 2450
Query: 702 DQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLL 761
+ +E+ +E +LQ E M+ Q E L ++ Q + EKD LL
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSEE----MQTVQQ---EQLLQETQALQQSFLSEKDSLL 2503
Query: 762 AEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELE 821
+ ER +E+ +++++ + D A +Q EE Q Q+++E
Sbjct: 2504 --------------------QRERFIEQ-EKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542
Query: 822 VLSEQYSQKCLENAHLAQALEAE-RQALRQCQRENQELNAHNQELNNRLAAEITRLRTLL 880
Q Q+ + + A+ + E + +R+ Q E Q+L ++ LA E RLR L
Sbjct: 2543 ----QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2598
Score = 49.3 bits (116), Expect = 2e-05
Identities = 89/356 (25%), Positives = 152/356 (42%), Gaps = 30/356 (8%)
Query: 514 KQEAELGEPDPEQKRSRARERRREGRSKTFDWAE-FRPIQQALAQERVGGVGPADTHEPL 572
K EAEL + E + +AR + + AE + Q+ L ER + + E L
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385
Query: 573 RPEAEPGELERERARRREERRK------RFG-MLDATDGPGTEDAAL--RMEVDRSPGLP 623
+ E+ R +AR E+ ++ G L T+ E L +E+ R
Sbjct: 2386 KLRV--AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443
Query: 624 MSD-LKTHNVHVEIEQRWHQVETTPLR---EEKQVPIAPVHLSSEDGGDRLSTHELTSLL 679
++ L+ +E E+ Q E L+ EE Q L + E SLL
Sbjct: 2444 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2503
Query: 680 EKELEQSQKEASDLLEQNRLLQDQLRVALG-REQSAREGYVLQATCERGFAAMEETH--Q 736
++E Q++A LEQ L QD++ A RE+ R+ ++ +R A+MEE Q
Sbjct: 2504 QRERFIEQEKAK--LEQ--LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2559
Query: 737 KKIEDLQRQHQRELEKL---REEKDRLLAEETAATISAIEAMKNAHREEM--ERELEKSQ 791
+ E+ R+ Q EL++L R +++ LLAEE ++ ++ HR + E+ SQ
Sbjct: 2560 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619
Query: 792 RSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQA 847
+ ++ + +AL E + + L + S + L+ A + A E +R A
Sbjct: 2620 VAATKTLPNGRDALDGPAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2673
Score = 47.4 bits (111), Expect = 7e-05
Identities = 63/316 (19%), Positives = 138/316 (43%), Gaps = 30/316 (9%)
Query: 676 TSLLEKELEQS------QKEASD----LLEQNRLLQDQLR-VALGREQSAREGYVLQATC 724
T + ++ELEQ +E++D L+ R Q+Q++ + L Q+ RE Q
Sbjct: 1195 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE----QLRQ 1250
Query: 725 ERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEME 784
E+ E H +K+E+ QR ++ + +++ + +L+ + A A K + E
Sbjct: 1251 EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1310
Query: 785 RELEKSQRSQISSVNSDVEALRRQYL----EELQSVQRELEVLSEQYSQKCLENAHLAQA 840
++ + + + S++ L QY+ E L+ ++ E + +Q +++ A + A
Sbjct: 1311 SVIQ--EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAA 1368
Query: 841 LEAERQALRQCQRENQELNAHNQELNNRLAAEITRL-RTLLTGDGGGEATGSPLAQGKDA 899
LE +RQ + + +EL R+ E+ R + + L Q + +
Sbjct: 1369 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1428
Query: 900 YELEVLLRVKESEIQ-----YLKQEISSLKDELQTALRDKKYASDKYKDIYT---ELSIA 951
E E+ + +++E +++EI ++ +L+ R + A + + + E
Sbjct: 1429 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1488
Query: 952 KAKADCDISRLKEQLK 967
K +A + RL+ Q++
Sbjct: 1489 KRQAQEEAERLRRQVQ 1504
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 75.5 bits (184), Expect = 2e-13
Identities = 128/514 (24%), Positives = 210/514 (40%), Gaps = 79/514 (15%)
Query: 510 RPTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQAL-AQERVGGVGPADT 568
R +++ +L + + +++AR+ RS+ E R ++ L A ER G G
Sbjct: 1384 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG-GAEGE 1442
Query: 569 HEPLRPEAEPGELERERARRREER----------RKRFGMLDATDGPGTEDAALRMEVDR 618
+ LR AE E ++ +A+ ER RKR ++ E A R +
Sbjct: 1443 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1502
Query: 619 SPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDG--GDRLSTHELT 676
L L+ E E+R Q E R+ QV + S+E R S E T
Sbjct: 1503 LQALEELRLQAE----EAERRLRQAEVERARQV-QVALETAQRSAEAELQSKRASFAEKT 1557
Query: 677 SLLEKEL------------------------EQSQKEASDLLEQNRLLQDQ-LRVALGRE 711
+ LE+ L E++++EA LE+ +L ++ LR+ L E
Sbjct: 1558 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1617
Query: 712 QSAREGYVLQATCERGFAAME-ETHQKKIEDLQRQHQRELEKLREEKDRLLAEETA---- 766
+ A++ + QA E+ E E ++ + Q QREL + EK R LAE TA
Sbjct: 1618 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1677
Query: 767 -ATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVL-- 823
A I + E +R+L + + +++ + R++ EL V+ E+EVL
Sbjct: 1678 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1737
Query: 824 ----SEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTL 879
+E+ S+ E + Q LEAE R+ E L A LA E R R L
Sbjct: 1738 SKARAEEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRA--------LAEEAKRQRQL 1787
Query: 880 LTGDGGGEATGSP--LAQGKDAY--------ELEVLLRVKESEIQYLKQEISSLKDELQT 929
D + + LA+ A E E+ L+ KE+E + L++ +DE
Sbjct: 1788 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR---LAEDEAFQ 1844
Query: 930 ALRDKKYASDKYKDIYTELSIAKAKADCDISRLK 963
R ++ A+ DI L+ + +D ++ R K
Sbjct: 1845 RRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1878
Score = 72.4 bits (176), Expect = 2e-12
Identities = 134/612 (21%), Positives = 251/612 (41%), Gaps = 107/612 (17%)
Query: 496 EEKNKSSCSFETCPRPTEKQEAELGE-----PDPEQKRSRARERRREGRSKTFDWAEFRP 550
EE+++S T + ++ EAE G + + R+ A E +R+ + D A R
Sbjct: 1743 EEESRS-----TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1797
Query: 551 IQQALAQERVGGVGPADTHEPLRPEAEPG----ELERERARRREE----RRKRFGMLDAT 602
+ + E++ +G A L+ EAE E E ER RR E +R+R A
Sbjct: 1798 EAERVLAEKLAAIGEATR---LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1854
Query: 603 DGPGTEDAALRM------EVDRSPGLPMSDLKTHN-VHVEIEQRWHQVETTPL-REEKQV 654
E+ ++ E++R GL L+ V EI E + E ++
Sbjct: 1855 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1914
Query: 655 PIAPVHLSSEDGGDRLSTHELTSLLEKEL----EQSQKEASDLLEQNRLLQD----QLRV 706
+ + ++ED EL + +++L E+ ++EA + ++++ ++ Q +
Sbjct: 1915 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1974
Query: 707 AL-------------------GREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQ 747
AL ++SAR+ + Q ++ A E+ H ++ +++ Q
Sbjct: 1975 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2034
Query: 748 RELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRR 807
+ L++ + D+L E AA +A EA + R + ERE +S+R + E L++
Sbjct: 2035 QTLQQEQSVLDQLRGEAEAARRAAEEAEEA--RVQAEREAAQSRRQV-----EEAERLKQ 2087
Query: 808 QYLEELQS---VQRELEVLSEQYSQKCLENAHLAQALEAERQA---------------LR 849
E+ Q+ Q E L ++ Q+ A QA ++QA LR
Sbjct: 2088 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2147
Query: 850 QCQRENQELNAHNQEL------NNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELE 903
Q + QEL +L N L E+ RL+ EAT + + + EL
Sbjct: 2148 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK--------AEATEAARQRSQVEEEL- 2198
Query: 904 VLLRVKESEIQYLKQEISSL--------KDELQTALRDKKYASDKYKDIYTELSIAKAKA 955
+RV+ E+ LK I + KD Q L+++ + + LS+A +A
Sbjct: 2199 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2258
Query: 956 DCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIR-- 1013
+ +L E+ A AL EK + + + K+ + L++ + Q R ++
Sbjct: 2259 -ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2317
Query: 1014 SKSVIEQVSWDT 1025
+ + +Q++ +T
Sbjct: 2318 KEQMAQQLAEET 2329
Score = 54.7 bits (130), Expect = 4e-07
Identities = 104/472 (22%), Positives = 195/472 (41%), Gaps = 78/472 (16%)
Query: 573 RPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNV 632
R A+P + ARRR+E+ + + D+ A+R ++ + L + +++ H
Sbjct: 1181 RESADPLGAWLQDARRRQEQIQAMPLADSQ--------AVREQLRQEQAL-LEEIERHGE 1231
Query: 633 HVEIEQRW----------HQVETTPLREEKQVPIAPVHLSSEDGGDR--------LSTH- 673
VE QR+ ++++ + + + +P G L TH
Sbjct: 1232 KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY 1291
Query: 674 -ELTSLLEKELEQSQKEASDLLEQNRLLQDQ----------LRVALGREQSAREGYV-LQ 721
ELT+L + ++ + + E+ RL + Q + AL +++ E + +
Sbjct: 1292 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1351
Query: 722 ATCERGFAAMEETHQKKI----------EDLQRQHQRELEKLREEKDRLLAEETAATISA 771
A ER +++ Q+++ + +R Q EL++LR+ + AE A A
Sbjct: 1352 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AEIQAKARQA 1408
Query: 772 IEAMKNAHREEME-----RELEKSQRSQISSVNSDVEALRRQYLE---ELQSVQRELEVL 823
A ++ R E E +LE ++R Q +++ALR + E + + Q E E L
Sbjct: 1409 EAAERSRLRIEEEIRVVRLQLEATER-QRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1467
Query: 824 SEQY----SQKCLENAHLAQALEAERQALRQCQRENQ---ELNAHNQELNNRL-AAEITR 875
Q +K LA ++AE +A R+ QR Q EL +E RL AE+ R
Sbjct: 1468 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1527
Query: 876 LRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKK 935
R + + + Q K A E +++ S +Q ++ L++E + + +
Sbjct: 1528 ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS-LQEEHVAVAQLREEAERRAQQQA 1586
Query: 936 YASDKYKDIYTELSIAKAKADCDISRLK------EQLKAATEALGEKSPDSA 981
A ++ EL + KA+ + RL+ Q K+ +A EK + A
Sbjct: 1587 EAERAREEAERELERWQLKAN-EALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1637
Score = 51.6 bits (122), Expect = 4e-06
Identities = 102/476 (21%), Positives = 183/476 (38%), Gaps = 63/476 (13%)
Query: 513 EKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPL 572
E + A + E+ R +A + R + + + + AQ R A E L
Sbjct: 2050 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKL 2106
Query: 573 RPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTH-- 630
R EAE R +A + R+K+ + + LR + L L+
Sbjct: 2107 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2166
Query: 631 ----NVHVEIEQRWHQVETTPLREEKQVP--IAPVHLSSEDGGDRLSTHELTS------- 677
N+ E QR T R+ QV + V + E+ + E +
Sbjct: 2167 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2226
Query: 678 ------LLEKELEQSQKEASDLLEQNRLLQDQLRVA-LGREQSAREGYVLQATCERGFAA 730
L++E E+ ++ A + + Q+ R+ L E A++ + + + A
Sbjct: 2227 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2286
Query: 731 MEETHQKKIEDLQRQHQREL-----EKLREEKDRL---LAEETAATISAIEAMKNAHREE 782
++E + K E Q Q+EL +L+E+K+++ LAEET +EA E
Sbjct: 2287 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA-------E 2339
Query: 783 MERELEKSQRSQISSVN-SDVEALRRQYLEELQSVQRELEVLSEQYSQKCL---ENAHLA 838
+R+LE S ++ + +++ + + E+ Q +++ E + E+ + L E L
Sbjct: 2340 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2399
Query: 839 QALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKD 898
Q LE +RQ + H+ E AE+ R + L + + L Q K
Sbjct: 2400 QTLEIQRQQ-----------SDHDAERLREAIAELEREKEKLQQE-------AKLLQLKS 2441
Query: 899 AYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAK 954
V E Q L+Q S KD L R + K + ++ + +AKA+
Sbjct: 2442 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD-EVAKAQ 2496
Score = 50.1 bits (118), Expect = 1e-05
Identities = 87/360 (24%), Positives = 157/360 (43%), Gaps = 58/360 (16%)
Query: 531 ARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAE----PGELERERA 586
A+E R + D A+ R + + + +E++ V A L+ EAE EL +E+A
Sbjct: 2255 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR---LKAEAELLQQQKELAQEQA 2311
Query: 587 RRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMS-DLKTHNVHV-EIEQRWHQVE 644
RR +E +++ A + G + +E +R L MS + + + V E+ + + E
Sbjct: 2312 RRLQEDKEQMAQQLAEETQGFQRT---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2368
Query: 645 TTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQS---QKEASDLLEQNRLLQ 701
R KQ +E+ G++L EL + + L Q+ Q++ SD + RL +
Sbjct: 2369 EDAQRFRKQ---------AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLRE 2418
Query: 702 DQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLL 761
+ +E+ +E +LQ E M+ Q E L ++ Q + EKD LL
Sbjct: 2419 AIAELEREKEKLQQEAKLLQLKSEE----MQTVQQ---EQLLQETQALQQSFLSEKDSLL 2471
Query: 762 AEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELE 821
+ ER +E+ +++++ + D A +Q EE Q Q+++E
Sbjct: 2472 --------------------QRERFIEQ-EKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2510
Query: 822 VLSEQYSQKCLENAHLAQALEAE-RQALRQCQRENQELNAHNQELNNRLAAEITRLRTLL 880
Q Q+ + + A+ + E + +R+ Q E Q+L ++ LA E RLR L
Sbjct: 2511 ----QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2566
Score = 49.3 bits (116), Expect = 2e-05
Identities = 89/356 (25%), Positives = 152/356 (42%), Gaps = 30/356 (8%)
Query: 514 KQEAELGEPDPEQKRSRARERRREGRSKTFDWAE-FRPIQQALAQERVGGVGPADTHEPL 572
K EAEL + E + +AR + + AE + Q+ L ER + + E L
Sbjct: 2294 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2353
Query: 573 RPEAEPGELERERARRREERRK------RFG-MLDATDGPGTEDAAL--RMEVDRSPGLP 623
+ E+ R +AR E+ ++ G L T+ E L +E+ R
Sbjct: 2354 KLRV--AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2411
Query: 624 MSD-LKTHNVHVEIEQRWHQVETTPLR---EEKQVPIAPVHLSSEDGGDRLSTHELTSLL 679
++ L+ +E E+ Q E L+ EE Q L + E SLL
Sbjct: 2412 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2471
Query: 680 EKELEQSQKEASDLLEQNRLLQDQLRVALG-REQSAREGYVLQATCERGFAAMEETH--Q 736
++E Q++A LEQ L QD++ A RE+ R+ ++ +R A+MEE Q
Sbjct: 2472 QRERFIEQEKAK--LEQ--LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2527
Query: 737 KKIEDLQRQHQRELEKL---REEKDRLLAEETAATISAIEAMKNAHREEM--ERELEKSQ 791
+ E+ R+ Q EL++L R +++ LLAEE ++ ++ HR + E+ SQ
Sbjct: 2528 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2587
Query: 792 RSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQA 847
+ ++ + +AL E + + L + S + L+ A + A E +R A
Sbjct: 2588 VAATKTLPNGRDALDGPAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2641
Score = 47.4 bits (111), Expect = 7e-05
Identities = 63/316 (19%), Positives = 138/316 (43%), Gaps = 30/316 (9%)
Query: 676 TSLLEKELEQS------QKEASD----LLEQNRLLQDQLR-VALGREQSAREGYVLQATC 724
T + ++ELEQ +E++D L+ R Q+Q++ + L Q+ RE Q
Sbjct: 1163 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE----QLRQ 1218
Query: 725 ERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEME 784
E+ E H +K+E+ QR ++ + +++ + +L+ + A A K + E
Sbjct: 1219 EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1278
Query: 785 RELEKSQRSQISSVNSDVEALRRQYL----EELQSVQRELEVLSEQYSQKCLENAHLAQA 840
++ + + + S++ L QY+ E L+ ++ E + +Q +++ A + A
Sbjct: 1279 SVIQ--EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAA 1336
Query: 841 LEAERQALRQCQRENQELNAHNQELNNRLAAEITRL-RTLLTGDGGGEATGSPLAQGKDA 899
LE +RQ + + +EL R+ E+ R + + L Q + +
Sbjct: 1337 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1396
Query: 900 YELEVLLRVKESEIQ-----YLKQEISSLKDELQTALRDKKYASDKYKDIYT---ELSIA 951
E E+ + +++E +++EI ++ +L+ R + A + + + E
Sbjct: 1397 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1456
Query: 952 KAKADCDISRLKEQLK 967
K +A + RL+ Q++
Sbjct: 1457 KRQAQEEAERLRRQVQ 1472
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 75.5 bits (184), Expect = 2e-13
Identities = 128/514 (24%), Positives = 210/514 (40%), Gaps = 79/514 (15%)
Query: 510 RPTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQAL-AQERVGGVGPADT 568
R +++ +L + + +++AR+ RS+ E R ++ L A ER G G
Sbjct: 1553 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG-GAEGE 1611
Query: 569 HEPLRPEAEPGELERERARRREER----------RKRFGMLDATDGPGTEDAALRMEVDR 618
+ LR AE E ++ +A+ ER RKR ++ E A R +
Sbjct: 1612 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1671
Query: 619 SPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDG--GDRLSTHELT 676
L L+ E E+R Q E R+ QV + S+E R S E T
Sbjct: 1672 LQALEELRLQAE----EAERRLRQAEVERARQV-QVALETAQRSAEAELQSKRASFAEKT 1726
Query: 677 SLLEKEL------------------------EQSQKEASDLLEQNRLLQDQ-LRVALGRE 711
+ LE+ L E++++EA LE+ +L ++ LR+ L E
Sbjct: 1727 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1786
Query: 712 QSAREGYVLQATCERGFAAME-ETHQKKIEDLQRQHQRELEKLREEKDRLLAEETA---- 766
+ A++ + QA E+ E E ++ + Q QREL + EK R LAE TA
Sbjct: 1787 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1846
Query: 767 -ATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVL-- 823
A I + E +R+L + + +++ + R++ EL V+ E+EVL
Sbjct: 1847 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1906
Query: 824 ----SEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTL 879
+E+ S+ E + Q LEAE R+ E L A LA E R R L
Sbjct: 1907 SKARAEEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRA--------LAEEAKRQRQL 1956
Query: 880 LTGDGGGEATGSP--LAQGKDAY--------ELEVLLRVKESEIQYLKQEISSLKDELQT 929
D + + LA+ A E E+ L+ KE+E + L++ +DE
Sbjct: 1957 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR---LAEDEAFQ 2013
Query: 930 ALRDKKYASDKYKDIYTELSIAKAKADCDISRLK 963
R ++ A+ DI L+ + +D ++ R K
Sbjct: 2014 RRRLEEQAAQHKADIEERLAQLRKASDSELERQK 2047
Score = 72.4 bits (176), Expect = 2e-12
Identities = 134/612 (21%), Positives = 251/612 (41%), Gaps = 107/612 (17%)
Query: 496 EEKNKSSCSFETCPRPTEKQEAELGE-----PDPEQKRSRARERRREGRSKTFDWAEFRP 550
EE+++S T + ++ EAE G + + R+ A E +R+ + D A R
Sbjct: 1912 EEESRS-----TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1966
Query: 551 IQQALAQERVGGVGPADTHEPLRPEAEPG----ELERERARRREE----RRKRFGMLDAT 602
+ + E++ +G A L+ EAE E E ER RR E +R+R A
Sbjct: 1967 EAERVLAEKLAAIGEATR---LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 2023
Query: 603 DGPGTEDAALRM------EVDRSPGLPMSDLKTHN-VHVEIEQRWHQVETTPL-REEKQV 654
E+ ++ E++R GL L+ V EI E + E ++
Sbjct: 2024 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 2083
Query: 655 PIAPVHLSSEDGGDRLSTHELTSLLEKEL----EQSQKEASDLLEQNRLLQD----QLRV 706
+ + ++ED EL + +++L E+ ++EA + ++++ ++ Q +
Sbjct: 2084 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2143
Query: 707 AL-------------------GREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQ 747
AL ++SAR+ + Q ++ A E+ H ++ +++ Q
Sbjct: 2144 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2203
Query: 748 RELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRR 807
+ L++ + D+L E AA +A EA + R + ERE +S+R + E L++
Sbjct: 2204 QTLQQEQSVLDQLRGEAEAARRAAEEAEEA--RVQAEREAAQSRRQV-----EEAERLKQ 2256
Query: 808 QYLEELQS---VQRELEVLSEQYSQKCLENAHLAQALEAERQA---------------LR 849
E+ Q+ Q E L ++ Q+ A QA ++QA LR
Sbjct: 2257 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2316
Query: 850 QCQRENQELNAHNQEL------NNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELE 903
Q + QEL +L N L E+ RL+ EAT + + + EL
Sbjct: 2317 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK--------AEATEAARQRSQVEEEL- 2367
Query: 904 VLLRVKESEIQYLKQEISSL--------KDELQTALRDKKYASDKYKDIYTELSIAKAKA 955
+RV+ E+ LK I + KD Q L+++ + + LS+A +A
Sbjct: 2368 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2427
Query: 956 DCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIR-- 1013
+ +L E+ A AL EK + + + K+ + L++ + Q R ++
Sbjct: 2428 -ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2486
Query: 1014 SKSVIEQVSWDT 1025
+ + +Q++ +T
Sbjct: 2487 KEQMAQQLAEET 2498
Score = 54.7 bits (130), Expect = 4e-07
Identities = 104/472 (22%), Positives = 195/472 (41%), Gaps = 78/472 (16%)
Query: 573 RPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNV 632
R A+P + ARRR+E+ + + D+ A+R ++ + L + +++ H
Sbjct: 1350 RESADPLGAWLQDARRRQEQIQAMPLADSQ--------AVREQLRQEQAL-LEEIERHGE 1400
Query: 633 HVEIEQRW----------HQVETTPLREEKQVPIAPVHLSSEDGGDR--------LSTH- 673
VE QR+ ++++ + + + +P G L TH
Sbjct: 1401 KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY 1460
Query: 674 -ELTSLLEKELEQSQKEASDLLEQNRLLQDQ----------LRVALGREQSAREGYV-LQ 721
ELT+L + ++ + + E+ RL + Q + AL +++ E + +
Sbjct: 1461 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1520
Query: 722 ATCERGFAAMEETHQKKI----------EDLQRQHQRELEKLREEKDRLLAEETAATISA 771
A ER +++ Q+++ + +R Q EL++LR+ + AE A A
Sbjct: 1521 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AEIQAKARQA 1577
Query: 772 IEAMKNAHREEME-----RELEKSQRSQISSVNSDVEALRRQYLE---ELQSVQRELEVL 823
A ++ R E E +LE ++R Q +++ALR + E + + Q E E L
Sbjct: 1578 EAAERSRLRIEEEIRVVRLQLEATER-QRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1636
Query: 824 SEQY----SQKCLENAHLAQALEAERQALRQCQRENQ---ELNAHNQELNNRL-AAEITR 875
Q +K LA ++AE +A R+ QR Q EL +E RL AE+ R
Sbjct: 1637 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1696
Query: 876 LRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKK 935
R + + + Q K A E +++ S +Q ++ L++E + + +
Sbjct: 1697 ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS-LQEEHVAVAQLREEAERRAQQQA 1755
Query: 936 YASDKYKDIYTELSIAKAKADCDISRLK------EQLKAATEALGEKSPDSA 981
A ++ EL + KA+ + RL+ Q K+ +A EK + A
Sbjct: 1756 EAERAREEAERELERWQLKAN-EALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1806
Score = 51.6 bits (122), Expect = 4e-06
Identities = 102/476 (21%), Positives = 183/476 (38%), Gaps = 63/476 (13%)
Query: 513 EKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPL 572
E + A + E+ R +A + R + + + + AQ R A E L
Sbjct: 2219 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKL 2275
Query: 573 RPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTH-- 630
R EAE R +A + R+K+ + + LR + L L+
Sbjct: 2276 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2335
Query: 631 ----NVHVEIEQRWHQVETTPLREEKQVP--IAPVHLSSEDGGDRLSTHELTS------- 677
N+ E QR T R+ QV + V + E+ + E +
Sbjct: 2336 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2395
Query: 678 ------LLEKELEQSQKEASDLLEQNRLLQDQLRVA-LGREQSAREGYVLQATCERGFAA 730
L++E E+ ++ A + + Q+ R+ L E A++ + + + A
Sbjct: 2396 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2455
Query: 731 MEETHQKKIEDLQRQHQREL-----EKLREEKDRL---LAEETAATISAIEAMKNAHREE 782
++E + K E Q Q+EL +L+E+K+++ LAEET +EA E
Sbjct: 2456 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA-------E 2508
Query: 783 MERELEKSQRSQISSVN-SDVEALRRQYLEELQSVQRELEVLSEQYSQKCL---ENAHLA 838
+R+LE S ++ + +++ + + E+ Q +++ E + E+ + L E L
Sbjct: 2509 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2568
Query: 839 QALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKD 898
Q LE +RQ + H+ E AE+ R + L + + L Q K
Sbjct: 2569 QTLEIQRQQ-----------SDHDAERLREAIAELEREKEKLQQE-------AKLLQLKS 2610
Query: 899 AYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAK 954
V E Q L+Q S KD L R + K + ++ + +AKA+
Sbjct: 2611 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD-EVAKAQ 2665
Score = 50.1 bits (118), Expect = 1e-05
Identities = 87/360 (24%), Positives = 157/360 (43%), Gaps = 58/360 (16%)
Query: 531 ARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAE----PGELERERA 586
A+E R + D A+ R + + + +E++ V A L+ EAE EL +E+A
Sbjct: 2424 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR---LKAEAELLQQQKELAQEQA 2480
Query: 587 RRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMS-DLKTHNVHV-EIEQRWHQVE 644
RR +E +++ A + G + +E +R L MS + + + V E+ + + E
Sbjct: 2481 RRLQEDKEQMAQQLAEETQGFQRT---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2537
Query: 645 TTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQS---QKEASDLLEQNRLLQ 701
R KQ +E+ G++L EL + + L Q+ Q++ SD + RL +
Sbjct: 2538 EDAQRFRKQ---------AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLRE 2587
Query: 702 DQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLL 761
+ +E+ +E +LQ E M+ Q E L ++ Q + EKD LL
Sbjct: 2588 AIAELEREKEKLQQEAKLLQLKSEE----MQTVQQ---EQLLQETQALQQSFLSEKDSLL 2640
Query: 762 AEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELE 821
+ ER +E+ +++++ + D A +Q EE Q Q+++E
Sbjct: 2641 --------------------QRERFIEQ-EKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2679
Query: 822 VLSEQYSQKCLENAHLAQALEAE-RQALRQCQRENQELNAHNQELNNRLAAEITRLRTLL 880
Q Q+ + + A+ + E + +R+ Q E Q+L ++ LA E RLR L
Sbjct: 2680 ----QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2735
Score = 49.3 bits (116), Expect = 2e-05
Identities = 89/356 (25%), Positives = 152/356 (42%), Gaps = 30/356 (8%)
Query: 514 KQEAELGEPDPEQKRSRARERRREGRSKTFDWAE-FRPIQQALAQERVGGVGPADTHEPL 572
K EAEL + E + +AR + + AE + Q+ L ER + + E L
Sbjct: 2463 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2522
Query: 573 RPEAEPGELERERARRREERRK------RFG-MLDATDGPGTEDAAL--RMEVDRSPGLP 623
+ E+ R +AR E+ ++ G L T+ E L +E+ R
Sbjct: 2523 KLRV--AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2580
Query: 624 MSD-LKTHNVHVEIEQRWHQVETTPLR---EEKQVPIAPVHLSSEDGGDRLSTHELTSLL 679
++ L+ +E E+ Q E L+ EE Q L + E SLL
Sbjct: 2581 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2640
Query: 680 EKELEQSQKEASDLLEQNRLLQDQLRVALG-REQSAREGYVLQATCERGFAAMEETH--Q 736
++E Q++A LEQ L QD++ A RE+ R+ ++ +R A+MEE Q
Sbjct: 2641 QRERFIEQEKAK--LEQ--LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2696
Query: 737 KKIEDLQRQHQRELEKL---REEKDRLLAEETAATISAIEAMKNAHREEM--ERELEKSQ 791
+ E+ R+ Q EL++L R +++ LLAEE ++ ++ HR + E+ SQ
Sbjct: 2697 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2756
Query: 792 RSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQA 847
+ ++ + +AL E + + L + S + L+ A + A E +R A
Sbjct: 2757 VAATKTLPNGRDALDGPAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2810
Score = 47.4 bits (111), Expect = 7e-05
Identities = 63/316 (19%), Positives = 138/316 (43%), Gaps = 30/316 (9%)
Query: 676 TSLLEKELEQS------QKEASD----LLEQNRLLQDQLR-VALGREQSAREGYVLQATC 724
T + ++ELEQ +E++D L+ R Q+Q++ + L Q+ RE Q
Sbjct: 1332 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE----QLRQ 1387
Query: 725 ERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEME 784
E+ E H +K+E+ QR ++ + +++ + +L+ + A A K + E
Sbjct: 1388 EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1447
Query: 785 RELEKSQRSQISSVNSDVEALRRQYL----EELQSVQRELEVLSEQYSQKCLENAHLAQA 840
++ + + + S++ L QY+ E L+ ++ E + +Q +++ A + A
Sbjct: 1448 SVIQ--EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAA 1505
Query: 841 LEAERQALRQCQRENQELNAHNQELNNRLAAEITRL-RTLLTGDGGGEATGSPLAQGKDA 899
LE +RQ + + +EL R+ E+ R + + L Q + +
Sbjct: 1506 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1565
Query: 900 YELEVLLRVKESEIQ-----YLKQEISSLKDELQTALRDKKYASDKYKDIYT---ELSIA 951
E E+ + +++E +++EI ++ +L+ R + A + + + E
Sbjct: 1566 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1625
Query: 952 KAKADCDISRLKEQLK 967
K +A + RL+ Q++
Sbjct: 1626 KRQAQEEAERLRRQVQ 1641
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 75.5 bits (184), Expect = 2e-13
Identities = 128/514 (24%), Positives = 210/514 (40%), Gaps = 79/514 (15%)
Query: 510 RPTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQAL-AQERVGGVGPADT 568
R +++ +L + + +++AR+ RS+ E R ++ L A ER G G
Sbjct: 1394 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG-GAEGE 1452
Query: 569 HEPLRPEAEPGELERERARRREER----------RKRFGMLDATDGPGTEDAALRMEVDR 618
+ LR AE E ++ +A+ ER RKR ++ E A R +
Sbjct: 1453 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1512
Query: 619 SPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDG--GDRLSTHELT 676
L L+ E E+R Q E R+ QV + S+E R S E T
Sbjct: 1513 LQALEELRLQAE----EAERRLRQAEVERARQV-QVALETAQRSAEAELQSKRASFAEKT 1567
Query: 677 SLLEKEL------------------------EQSQKEASDLLEQNRLLQDQ-LRVALGRE 711
+ LE+ L E++++EA LE+ +L ++ LR+ L E
Sbjct: 1568 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1627
Query: 712 QSAREGYVLQATCERGFAAME-ETHQKKIEDLQRQHQRELEKLREEKDRLLAEETA---- 766
+ A++ + QA E+ E E ++ + Q QREL + EK R LAE TA
Sbjct: 1628 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1687
Query: 767 -ATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVL-- 823
A I + E +R+L + + +++ + R++ EL V+ E+EVL
Sbjct: 1688 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1747
Query: 824 ----SEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTL 879
+E+ S+ E + Q LEAE R+ E L A LA E R R L
Sbjct: 1748 SKARAEEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRA--------LAEEAKRQRQL 1797
Query: 880 LTGDGGGEATGSP--LAQGKDAY--------ELEVLLRVKESEIQYLKQEISSLKDELQT 929
D + + LA+ A E E+ L+ KE+E + L++ +DE
Sbjct: 1798 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR---LAEDEAFQ 1854
Query: 930 ALRDKKYASDKYKDIYTELSIAKAKADCDISRLK 963
R ++ A+ DI L+ + +D ++ R K
Sbjct: 1855 RRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1888
Score = 72.4 bits (176), Expect = 2e-12
Identities = 134/612 (21%), Positives = 251/612 (41%), Gaps = 107/612 (17%)
Query: 496 EEKNKSSCSFETCPRPTEKQEAELGE-----PDPEQKRSRARERRREGRSKTFDWAEFRP 550
EE+++S T + ++ EAE G + + R+ A E +R+ + D A R
Sbjct: 1753 EEESRS-----TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1807
Query: 551 IQQALAQERVGGVGPADTHEPLRPEAEPG----ELERERARRREE----RRKRFGMLDAT 602
+ + E++ +G A L+ EAE E E ER RR E +R+R A
Sbjct: 1808 EAERVLAEKLAAIGEATR---LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1864
Query: 603 DGPGTEDAALRM------EVDRSPGLPMSDLKTHN-VHVEIEQRWHQVETTPL-REEKQV 654
E+ ++ E++R GL L+ V EI E + E ++
Sbjct: 1865 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1924
Query: 655 PIAPVHLSSEDGGDRLSTHELTSLLEKEL----EQSQKEASDLLEQNRLLQD----QLRV 706
+ + ++ED EL + +++L E+ ++EA + ++++ ++ Q +
Sbjct: 1925 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1984
Query: 707 AL-------------------GREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQ 747
AL ++SAR+ + Q ++ A E+ H ++ +++ Q
Sbjct: 1985 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2044
Query: 748 RELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRR 807
+ L++ + D+L E AA +A EA + R + ERE +S+R + E L++
Sbjct: 2045 QTLQQEQSVLDQLRGEAEAARRAAEEAEEA--RVQAEREAAQSRRQV-----EEAERLKQ 2097
Query: 808 QYLEELQS---VQRELEVLSEQYSQKCLENAHLAQALEAERQA---------------LR 849
E+ Q+ Q E L ++ Q+ A QA ++QA LR
Sbjct: 2098 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2157
Query: 850 QCQRENQELNAHNQEL------NNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELE 903
Q + QEL +L N L E+ RL+ EAT + + + EL
Sbjct: 2158 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK--------AEATEAARQRSQVEEEL- 2208
Query: 904 VLLRVKESEIQYLKQEISSL--------KDELQTALRDKKYASDKYKDIYTELSIAKAKA 955
+RV+ E+ LK I + KD Q L+++ + + LS+A +A
Sbjct: 2209 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2268
Query: 956 DCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIR-- 1013
+ +L E+ A AL EK + + + K+ + L++ + Q R ++
Sbjct: 2269 -ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2327
Query: 1014 SKSVIEQVSWDT 1025
+ + +Q++ +T
Sbjct: 2328 KEQMAQQLAEET 2339
Score = 54.7 bits (130), Expect = 4e-07
Identities = 104/472 (22%), Positives = 195/472 (41%), Gaps = 78/472 (16%)
Query: 573 RPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNV 632
R A+P + ARRR+E+ + + D+ A+R ++ + L + +++ H
Sbjct: 1191 RESADPLGAWLQDARRRQEQIQAMPLADSQ--------AVREQLRQEQAL-LEEIERHGE 1241
Query: 633 HVEIEQRW----------HQVETTPLREEKQVPIAPVHLSSEDGGDR--------LSTH- 673
VE QR+ ++++ + + + +P G L TH
Sbjct: 1242 KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY 1301
Query: 674 -ELTSLLEKELEQSQKEASDLLEQNRLLQDQ----------LRVALGREQSAREGYV-LQ 721
ELT+L + ++ + + E+ RL + Q + AL +++ E + +
Sbjct: 1302 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1361
Query: 722 ATCERGFAAMEETHQKKI----------EDLQRQHQRELEKLREEKDRLLAEETAATISA 771
A ER +++ Q+++ + +R Q EL++LR+ + AE A A
Sbjct: 1362 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AEIQAKARQA 1418
Query: 772 IEAMKNAHREEME-----RELEKSQRSQISSVNSDVEALRRQYLE---ELQSVQRELEVL 823
A ++ R E E +LE ++R Q +++ALR + E + + Q E E L
Sbjct: 1419 EAAERSRLRIEEEIRVVRLQLEATER-QRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1477
Query: 824 SEQY----SQKCLENAHLAQALEAERQALRQCQRENQ---ELNAHNQELNNRL-AAEITR 875
Q +K LA ++AE +A R+ QR Q EL +E RL AE+ R
Sbjct: 1478 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1537
Query: 876 LRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKK 935
R + + + Q K A E +++ S +Q ++ L++E + + +
Sbjct: 1538 ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS-LQEEHVAVAQLREEAERRAQQQA 1596
Query: 936 YASDKYKDIYTELSIAKAKADCDISRLK------EQLKAATEALGEKSPDSA 981
A ++ EL + KA+ + RL+ Q K+ +A EK + A
Sbjct: 1597 EAERAREEAERELERWQLKAN-EALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1647
Score = 51.6 bits (122), Expect = 4e-06
Identities = 102/476 (21%), Positives = 183/476 (38%), Gaps = 63/476 (13%)
Query: 513 EKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPL 572
E + A + E+ R +A + R + + + + AQ R A E L
Sbjct: 2060 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKL 2116
Query: 573 RPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTH-- 630
R EAE R +A + R+K+ + + LR + L L+
Sbjct: 2117 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2176
Query: 631 ----NVHVEIEQRWHQVETTPLREEKQVP--IAPVHLSSEDGGDRLSTHELTS------- 677
N+ E QR T R+ QV + V + E+ + E +
Sbjct: 2177 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2236
Query: 678 ------LLEKELEQSQKEASDLLEQNRLLQDQLRVA-LGREQSAREGYVLQATCERGFAA 730
L++E E+ ++ A + + Q+ R+ L E A++ + + + A
Sbjct: 2237 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2296
Query: 731 MEETHQKKIEDLQRQHQREL-----EKLREEKDRL---LAEETAATISAIEAMKNAHREE 782
++E + K E Q Q+EL +L+E+K+++ LAEET +EA E
Sbjct: 2297 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA-------E 2349
Query: 783 MERELEKSQRSQISSVN-SDVEALRRQYLEELQSVQRELEVLSEQYSQKCL---ENAHLA 838
+R+LE S ++ + +++ + + E+ Q +++ E + E+ + L E L
Sbjct: 2350 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2409
Query: 839 QALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKD 898
Q LE +RQ + H+ E AE+ R + L + + L Q K
Sbjct: 2410 QTLEIQRQQ-----------SDHDAERLREAIAELEREKEKLQQE-------AKLLQLKS 2451
Query: 899 AYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAK 954
V E Q L+Q S KD L R + K + ++ + +AKA+
Sbjct: 2452 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD-EVAKAQ 2506
Score = 50.1 bits (118), Expect = 1e-05
Identities = 87/360 (24%), Positives = 157/360 (43%), Gaps = 58/360 (16%)
Query: 531 ARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAE----PGELERERA 586
A+E R + D A+ R + + + +E++ V A L+ EAE EL +E+A
Sbjct: 2265 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR---LKAEAELLQQQKELAQEQA 2321
Query: 587 RRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMS-DLKTHNVHV-EIEQRWHQVE 644
RR +E +++ A + G + +E +R L MS + + + V E+ + + E
Sbjct: 2322 RRLQEDKEQMAQQLAEETQGFQRT---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2378
Query: 645 TTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQS---QKEASDLLEQNRLLQ 701
R KQ +E+ G++L EL + + L Q+ Q++ SD + RL +
Sbjct: 2379 EDAQRFRKQ---------AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLRE 2428
Query: 702 DQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLL 761
+ +E+ +E +LQ E M+ Q E L ++ Q + EKD LL
Sbjct: 2429 AIAELEREKEKLQQEAKLLQLKSEE----MQTVQQ---EQLLQETQALQQSFLSEKDSLL 2481
Query: 762 AEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELE 821
+ ER +E+ +++++ + D A +Q EE Q Q+++E
Sbjct: 2482 --------------------QRERFIEQ-EKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2520
Query: 822 VLSEQYSQKCLENAHLAQALEAE-RQALRQCQRENQELNAHNQELNNRLAAEITRLRTLL 880
Q Q+ + + A+ + E + +R+ Q E Q+L ++ LA E RLR L
Sbjct: 2521 ----QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2576
Score = 49.3 bits (116), Expect = 2e-05
Identities = 89/356 (25%), Positives = 152/356 (42%), Gaps = 30/356 (8%)
Query: 514 KQEAELGEPDPEQKRSRARERRREGRSKTFDWAE-FRPIQQALAQERVGGVGPADTHEPL 572
K EAEL + E + +AR + + AE + Q+ L ER + + E L
Sbjct: 2304 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2363
Query: 573 RPEAEPGELERERARRREERRK------RFG-MLDATDGPGTEDAAL--RMEVDRSPGLP 623
+ E+ R +AR E+ ++ G L T+ E L +E+ R
Sbjct: 2364 KLRV--AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2421
Query: 624 MSD-LKTHNVHVEIEQRWHQVETTPLR---EEKQVPIAPVHLSSEDGGDRLSTHELTSLL 679
++ L+ +E E+ Q E L+ EE Q L + E SLL
Sbjct: 2422 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2481
Query: 680 EKELEQSQKEASDLLEQNRLLQDQLRVALG-REQSAREGYVLQATCERGFAAMEETH--Q 736
++E Q++A LEQ L QD++ A RE+ R+ ++ +R A+MEE Q
Sbjct: 2482 QRERFIEQEKAK--LEQ--LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2537
Query: 737 KKIEDLQRQHQRELEKL---REEKDRLLAEETAATISAIEAMKNAHREEM--ERELEKSQ 791
+ E+ R+ Q EL++L R +++ LLAEE ++ ++ HR + E+ SQ
Sbjct: 2538 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2597
Query: 792 RSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQA 847
+ ++ + +AL E + + L + S + L+ A + A E +R A
Sbjct: 2598 VAATKTLPNGRDALDGPAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2651
Score = 47.4 bits (111), Expect = 7e-05
Identities = 63/316 (19%), Positives = 138/316 (43%), Gaps = 30/316 (9%)
Query: 676 TSLLEKELEQS------QKEASD----LLEQNRLLQDQLR-VALGREQSAREGYVLQATC 724
T + ++ELEQ +E++D L+ R Q+Q++ + L Q+ RE Q
Sbjct: 1173 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE----QLRQ 1228
Query: 725 ERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEME 784
E+ E H +K+E+ QR ++ + +++ + +L+ + A A K + E
Sbjct: 1229 EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1288
Query: 785 RELEKSQRSQISSVNSDVEALRRQYL----EELQSVQRELEVLSEQYSQKCLENAHLAQA 840
++ + + + S++ L QY+ E L+ ++ E + +Q +++ A + A
Sbjct: 1289 SVIQ--EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAA 1346
Query: 841 LEAERQALRQCQRENQELNAHNQELNNRLAAEITRL-RTLLTGDGGGEATGSPLAQGKDA 899
LE +RQ + + +EL R+ E+ R + + L Q + +
Sbjct: 1347 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1406
Query: 900 YELEVLLRVKESEIQ-----YLKQEISSLKDELQTALRDKKYASDKYKDIYT---ELSIA 951
E E+ + +++E +++EI ++ +L+ R + A + + + E
Sbjct: 1407 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1466
Query: 952 KAKADCDISRLKEQLK 967
K +A + RL+ Q++
Sbjct: 1467 KRQAQEEAERLRRQVQ 1482
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 75.5 bits (184), Expect = 2e-13
Identities = 128/514 (24%), Positives = 210/514 (40%), Gaps = 79/514 (15%)
Query: 510 RPTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQAL-AQERVGGVGPADT 568
R +++ +L + + +++AR+ RS+ E R ++ L A ER G G
Sbjct: 1402 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG-GAEGE 1460
Query: 569 HEPLRPEAEPGELERERARRREER----------RKRFGMLDATDGPGTEDAALRMEVDR 618
+ LR AE E ++ +A+ ER RKR ++ E A R +
Sbjct: 1461 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1520
Query: 619 SPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDG--GDRLSTHELT 676
L L+ E E+R Q E R+ QV + S+E R S E T
Sbjct: 1521 LQALEELRLQAE----EAERRLRQAEVERARQV-QVALETAQRSAEAELQSKRASFAEKT 1575
Query: 677 SLLEKEL------------------------EQSQKEASDLLEQNRLLQDQ-LRVALGRE 711
+ LE+ L E++++EA LE+ +L ++ LR+ L E
Sbjct: 1576 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1635
Query: 712 QSAREGYVLQATCERGFAAME-ETHQKKIEDLQRQHQRELEKLREEKDRLLAEETA---- 766
+ A++ + QA E+ E E ++ + Q QREL + EK R LAE TA
Sbjct: 1636 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1695
Query: 767 -ATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVL-- 823
A I + E +R+L + + +++ + R++ EL V+ E+EVL
Sbjct: 1696 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1755
Query: 824 ----SEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTL 879
+E+ S+ E + Q LEAE R+ E L A LA E R R L
Sbjct: 1756 SKARAEEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRA--------LAEEAKRQRQL 1805
Query: 880 LTGDGGGEATGSP--LAQGKDAY--------ELEVLLRVKESEIQYLKQEISSLKDELQT 929
D + + LA+ A E E+ L+ KE+E + L++ +DE
Sbjct: 1806 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR---LAEDEAFQ 1862
Query: 930 ALRDKKYASDKYKDIYTELSIAKAKADCDISRLK 963
R ++ A+ DI L+ + +D ++ R K
Sbjct: 1863 RRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1896
Score = 72.4 bits (176), Expect = 2e-12
Identities = 134/612 (21%), Positives = 251/612 (41%), Gaps = 107/612 (17%)
Query: 496 EEKNKSSCSFETCPRPTEKQEAELGE-----PDPEQKRSRARERRREGRSKTFDWAEFRP 550
EE+++S T + ++ EAE G + + R+ A E +R+ + D A R
Sbjct: 1761 EEESRS-----TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1815
Query: 551 IQQALAQERVGGVGPADTHEPLRPEAEPG----ELERERARRREE----RRKRFGMLDAT 602
+ + E++ +G A L+ EAE E E ER RR E +R+R A
Sbjct: 1816 EAERVLAEKLAAIGEATR---LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1872
Query: 603 DGPGTEDAALRM------EVDRSPGLPMSDLKTHN-VHVEIEQRWHQVETTPL-REEKQV 654
E+ ++ E++R GL L+ V EI E + E ++
Sbjct: 1873 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1932
Query: 655 PIAPVHLSSEDGGDRLSTHELTSLLEKEL----EQSQKEASDLLEQNRLLQD----QLRV 706
+ + ++ED EL + +++L E+ ++EA + ++++ ++ Q +
Sbjct: 1933 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1992
Query: 707 AL-------------------GREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQ 747
AL ++SAR+ + Q ++ A E+ H ++ +++ Q
Sbjct: 1993 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2052
Query: 748 RELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRR 807
+ L++ + D+L E AA +A EA + R + ERE +S+R + E L++
Sbjct: 2053 QTLQQEQSVLDQLRGEAEAARRAAEEAEEA--RVQAEREAAQSRRQV-----EEAERLKQ 2105
Query: 808 QYLEELQS---VQRELEVLSEQYSQKCLENAHLAQALEAERQA---------------LR 849
E+ Q+ Q E L ++ Q+ A QA ++QA LR
Sbjct: 2106 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2165
Query: 850 QCQRENQELNAHNQEL------NNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELE 903
Q + QEL +L N L E+ RL+ EAT + + + EL
Sbjct: 2166 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK--------AEATEAARQRSQVEEEL- 2216
Query: 904 VLLRVKESEIQYLKQEISSL--------KDELQTALRDKKYASDKYKDIYTELSIAKAKA 955
+RV+ E+ LK I + KD Q L+++ + + LS+A +A
Sbjct: 2217 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2276
Query: 956 DCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIR-- 1013
+ +L E+ A AL EK + + + K+ + L++ + Q R ++
Sbjct: 2277 -ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2335
Query: 1014 SKSVIEQVSWDT 1025
+ + +Q++ +T
Sbjct: 2336 KEQMAQQLAEET 2347
Score = 54.7 bits (130), Expect = 4e-07
Identities = 104/472 (22%), Positives = 195/472 (41%), Gaps = 78/472 (16%)
Query: 573 RPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNV 632
R A+P + ARRR+E+ + + D+ A+R ++ + L + +++ H
Sbjct: 1199 RESADPLGAWLQDARRRQEQIQAMPLADSQ--------AVREQLRQEQAL-LEEIERHGE 1249
Query: 633 HVEIEQRW----------HQVETTPLREEKQVPIAPVHLSSEDGGDR--------LSTH- 673
VE QR+ ++++ + + + +P G L TH
Sbjct: 1250 KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY 1309
Query: 674 -ELTSLLEKELEQSQKEASDLLEQNRLLQDQ----------LRVALGREQSAREGYV-LQ 721
ELT+L + ++ + + E+ RL + Q + AL +++ E + +
Sbjct: 1310 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1369
Query: 722 ATCERGFAAMEETHQKKI----------EDLQRQHQRELEKLREEKDRLLAEETAATISA 771
A ER +++ Q+++ + +R Q EL++LR+ + AE A A
Sbjct: 1370 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AEIQAKARQA 1426
Query: 772 IEAMKNAHREEME-----RELEKSQRSQISSVNSDVEALRRQYLE---ELQSVQRELEVL 823
A ++ R E E +LE ++R Q +++ALR + E + + Q E E L
Sbjct: 1427 EAAERSRLRIEEEIRVVRLQLEATER-QRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1485
Query: 824 SEQY----SQKCLENAHLAQALEAERQALRQCQRENQ---ELNAHNQELNNRL-AAEITR 875
Q +K LA ++AE +A R+ QR Q EL +E RL AE+ R
Sbjct: 1486 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1545
Query: 876 LRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKK 935
R + + + Q K A E +++ S +Q ++ L++E + + +
Sbjct: 1546 ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS-LQEEHVAVAQLREEAERRAQQQA 1604
Query: 936 YASDKYKDIYTELSIAKAKADCDISRLK------EQLKAATEALGEKSPDSA 981
A ++ EL + KA+ + RL+ Q K+ +A EK + A
Sbjct: 1605 EAERAREEAERELERWQLKAN-EALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1655
Score = 51.6 bits (122), Expect = 4e-06
Identities = 102/476 (21%), Positives = 183/476 (38%), Gaps = 63/476 (13%)
Query: 513 EKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPL 572
E + A + E+ R +A + R + + + + AQ R A E L
Sbjct: 2068 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKL 2124
Query: 573 RPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTH-- 630
R EAE R +A + R+K+ + + LR + L L+
Sbjct: 2125 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2184
Query: 631 ----NVHVEIEQRWHQVETTPLREEKQVP--IAPVHLSSEDGGDRLSTHELTS------- 677
N+ E QR T R+ QV + V + E+ + E +
Sbjct: 2185 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2244
Query: 678 ------LLEKELEQSQKEASDLLEQNRLLQDQLRVA-LGREQSAREGYVLQATCERGFAA 730
L++E E+ ++ A + + Q+ R+ L E A++ + + + A
Sbjct: 2245 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2304
Query: 731 MEETHQKKIEDLQRQHQREL-----EKLREEKDRL---LAEETAATISAIEAMKNAHREE 782
++E + K E Q Q+EL +L+E+K+++ LAEET +EA E
Sbjct: 2305 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA-------E 2357
Query: 783 MERELEKSQRSQISSVN-SDVEALRRQYLEELQSVQRELEVLSEQYSQKCL---ENAHLA 838
+R+LE S ++ + +++ + + E+ Q +++ E + E+ + L E L
Sbjct: 2358 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2417
Query: 839 QALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKD 898
Q LE +RQ + H+ E AE+ R + L + + L Q K
Sbjct: 2418 QTLEIQRQQ-----------SDHDAERLREAIAELEREKEKLQQE-------AKLLQLKS 2459
Query: 899 AYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAK 954
V E Q L+Q S KD L R + K + ++ + +AKA+
Sbjct: 2460 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD-EVAKAQ 2514
Score = 50.1 bits (118), Expect = 1e-05
Identities = 87/360 (24%), Positives = 157/360 (43%), Gaps = 58/360 (16%)
Query: 531 ARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAE----PGELERERA 586
A+E R + D A+ R + + + +E++ V A L+ EAE EL +E+A
Sbjct: 2273 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR---LKAEAELLQQQKELAQEQA 2329
Query: 587 RRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMS-DLKTHNVHV-EIEQRWHQVE 644
RR +E +++ A + G + +E +R L MS + + + V E+ + + E
Sbjct: 2330 RRLQEDKEQMAQQLAEETQGFQRT---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2386
Query: 645 TTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQS---QKEASDLLEQNRLLQ 701
R KQ +E+ G++L EL + + L Q+ Q++ SD + RL +
Sbjct: 2387 EDAQRFRKQ---------AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLRE 2436
Query: 702 DQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLL 761
+ +E+ +E +LQ E M+ Q E L ++ Q + EKD LL
Sbjct: 2437 AIAELEREKEKLQQEAKLLQLKSEE----MQTVQQ---EQLLQETQALQQSFLSEKDSLL 2489
Query: 762 AEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELE 821
+ ER +E+ +++++ + D A +Q EE Q Q+++E
Sbjct: 2490 --------------------QRERFIEQ-EKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2528
Query: 822 VLSEQYSQKCLENAHLAQALEAE-RQALRQCQRENQELNAHNQELNNRLAAEITRLRTLL 880
Q Q+ + + A+ + E + +R+ Q E Q+L ++ LA E RLR L
Sbjct: 2529 ----QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2584
Score = 49.3 bits (116), Expect = 2e-05
Identities = 89/356 (25%), Positives = 152/356 (42%), Gaps = 30/356 (8%)
Query: 514 KQEAELGEPDPEQKRSRARERRREGRSKTFDWAE-FRPIQQALAQERVGGVGPADTHEPL 572
K EAEL + E + +AR + + AE + Q+ L ER + + E L
Sbjct: 2312 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2371
Query: 573 RPEAEPGELERERARRREERRK------RFG-MLDATDGPGTEDAAL--RMEVDRSPGLP 623
+ E+ R +AR E+ ++ G L T+ E L +E+ R
Sbjct: 2372 KLRV--AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2429
Query: 624 MSD-LKTHNVHVEIEQRWHQVETTPLR---EEKQVPIAPVHLSSEDGGDRLSTHELTSLL 679
++ L+ +E E+ Q E L+ EE Q L + E SLL
Sbjct: 2430 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2489
Query: 680 EKELEQSQKEASDLLEQNRLLQDQLRVALG-REQSAREGYVLQATCERGFAAMEETH--Q 736
++E Q++A LEQ L QD++ A RE+ R+ ++ +R A+MEE Q
Sbjct: 2490 QRERFIEQEKAK--LEQ--LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2545
Query: 737 KKIEDLQRQHQRELEKL---REEKDRLLAEETAATISAIEAMKNAHREEM--ERELEKSQ 791
+ E+ R+ Q EL++L R +++ LLAEE ++ ++ HR + E+ SQ
Sbjct: 2546 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2605
Query: 792 RSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQA 847
+ ++ + +AL E + + L + S + L+ A + A E +R A
Sbjct: 2606 VAATKTLPNGRDALDGPAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2659
Score = 47.4 bits (111), Expect = 7e-05
Identities = 63/316 (19%), Positives = 138/316 (43%), Gaps = 30/316 (9%)
Query: 676 TSLLEKELEQS------QKEASD----LLEQNRLLQDQLR-VALGREQSAREGYVLQATC 724
T + ++ELEQ +E++D L+ R Q+Q++ + L Q+ RE Q
Sbjct: 1181 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE----QLRQ 1236
Query: 725 ERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEME 784
E+ E H +K+E+ QR ++ + +++ + +L+ + A A K + E
Sbjct: 1237 EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1296
Query: 785 RELEKSQRSQISSVNSDVEALRRQYL----EELQSVQRELEVLSEQYSQKCLENAHLAQA 840
++ + + + S++ L QY+ E L+ ++ E + +Q +++ A + A
Sbjct: 1297 SVIQ--EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAA 1354
Query: 841 LEAERQALRQCQRENQELNAHNQELNNRLAAEITRL-RTLLTGDGGGEATGSPLAQGKDA 899
LE +RQ + + +EL R+ E+ R + + L Q + +
Sbjct: 1355 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1414
Query: 900 YELEVLLRVKESEIQ-----YLKQEISSLKDELQTALRDKKYASDKYKDIYT---ELSIA 951
E E+ + +++E +++EI ++ +L+ R + A + + + E
Sbjct: 1415 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1474
Query: 952 KAKADCDISRLKEQLK 967
K +A + RL+ Q++
Sbjct: 1475 KRQAQEEAERLRRQVQ 1490
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 75.5 bits (184), Expect = 2e-13
Identities = 128/514 (24%), Positives = 210/514 (40%), Gaps = 79/514 (15%)
Query: 510 RPTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQAL-AQERVGGVGPADT 568
R +++ +L + + +++AR+ RS+ E R ++ L A ER G G
Sbjct: 1443 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG-GAEGE 1501
Query: 569 HEPLRPEAEPGELERERARRREER----------RKRFGMLDATDGPGTEDAALRMEVDR 618
+ LR AE E ++ +A+ ER RKR ++ E A R +
Sbjct: 1502 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1561
Query: 619 SPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDG--GDRLSTHELT 676
L L+ E E+R Q E R+ QV + S+E R S E T
Sbjct: 1562 LQALEELRLQAE----EAERRLRQAEVERARQV-QVALETAQRSAEAELQSKRASFAEKT 1616
Query: 677 SLLEKEL------------------------EQSQKEASDLLEQNRLLQDQ-LRVALGRE 711
+ LE+ L E++++EA LE+ +L ++ LR+ L E
Sbjct: 1617 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1676
Query: 712 QSAREGYVLQATCERGFAAME-ETHQKKIEDLQRQHQRELEKLREEKDRLLAEETA---- 766
+ A++ + QA E+ E E ++ + Q QREL + EK R LAE TA
Sbjct: 1677 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1736
Query: 767 -ATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVL-- 823
A I + E +R+L + + +++ + R++ EL V+ E+EVL
Sbjct: 1737 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1796
Query: 824 ----SEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTL 879
+E+ S+ E + Q LEAE R+ E L A LA E R R L
Sbjct: 1797 SKARAEEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRA--------LAEEAKRQRQL 1846
Query: 880 LTGDGGGEATGSP--LAQGKDAY--------ELEVLLRVKESEIQYLKQEISSLKDELQT 929
D + + LA+ A E E+ L+ KE+E + L++ +DE
Sbjct: 1847 AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR---LAEDEAFQ 1903
Query: 930 ALRDKKYASDKYKDIYTELSIAKAKADCDISRLK 963
R ++ A+ DI L+ + +D ++ R K
Sbjct: 1904 RRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1937
Score = 72.4 bits (176), Expect = 2e-12
Identities = 134/612 (21%), Positives = 251/612 (41%), Gaps = 107/612 (17%)
Query: 496 EEKNKSSCSFETCPRPTEKQEAELGE-----PDPEQKRSRARERRREGRSKTFDWAEFRP 550
EE+++S T + ++ EAE G + + R+ A E +R+ + D A R
Sbjct: 1802 EEESRS-----TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1856
Query: 551 IQQALAQERVGGVGPADTHEPLRPEAEPG----ELERERARRREE----RRKRFGMLDAT 602
+ + E++ +G A L+ EAE E E ER RR E +R+R A
Sbjct: 1857 EAERVLAEKLAAIGEATR---LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1913
Query: 603 DGPGTEDAALRM------EVDRSPGLPMSDLKTHN-VHVEIEQRWHQVETTPL-REEKQV 654
E+ ++ E++R GL L+ V EI E + E ++
Sbjct: 1914 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1973
Query: 655 PIAPVHLSSEDGGDRLSTHELTSLLEKEL----EQSQKEASDLLEQNRLLQD----QLRV 706
+ + ++ED EL + +++L E+ ++EA + ++++ ++ Q +
Sbjct: 1974 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2033
Query: 707 AL-------------------GREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQ 747
AL ++SAR+ + Q ++ A E+ H ++ +++ Q
Sbjct: 2034 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2093
Query: 748 RELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRR 807
+ L++ + D+L E AA +A EA + R + ERE +S+R + E L++
Sbjct: 2094 QTLQQEQSVLDQLRGEAEAARRAAEEAEEA--RVQAEREAAQSRRQV-----EEAERLKQ 2146
Query: 808 QYLEELQS---VQRELEVLSEQYSQKCLENAHLAQALEAERQA---------------LR 849
E+ Q+ Q E L ++ Q+ A QA ++QA LR
Sbjct: 2147 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2206
Query: 850 QCQRENQELNAHNQEL------NNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELE 903
Q + QEL +L N L E+ RL+ EAT + + + EL
Sbjct: 2207 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK--------AEATEAARQRSQVEEEL- 2257
Query: 904 VLLRVKESEIQYLKQEISSL--------KDELQTALRDKKYASDKYKDIYTELSIAKAKA 955
+RV+ E+ LK I + KD Q L+++ + + LS+A +A
Sbjct: 2258 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2317
Query: 956 DCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIR-- 1013
+ +L E+ A AL EK + + + K+ + L++ + Q R ++
Sbjct: 2318 -ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2376
Query: 1014 SKSVIEQVSWDT 1025
+ + +Q++ +T
Sbjct: 2377 KEQMAQQLAEET 2388
Score = 54.7 bits (130), Expect = 4e-07
Identities = 104/472 (22%), Positives = 195/472 (41%), Gaps = 78/472 (16%)
Query: 573 RPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNV 632
R A+P + ARRR+E+ + + D+ A+R ++ + L + +++ H
Sbjct: 1240 RESADPLGAWLQDARRRQEQIQAMPLADSQ--------AVREQLRQEQAL-LEEIERHGE 1290
Query: 633 HVEIEQRW----------HQVETTPLREEKQVPIAPVHLSSEDGGDR--------LSTH- 673
VE QR+ ++++ + + + +P G L TH
Sbjct: 1291 KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY 1350
Query: 674 -ELTSLLEKELEQSQKEASDLLEQNRLLQDQ----------LRVALGREQSAREGYV-LQ 721
ELT+L + ++ + + E+ RL + Q + AL +++ E + +
Sbjct: 1351 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1410
Query: 722 ATCERGFAAMEETHQKKI----------EDLQRQHQRELEKLREEKDRLLAEETAATISA 771
A ER +++ Q+++ + +R Q EL++LR+ + AE A A
Sbjct: 1411 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AEIQAKARQA 1467
Query: 772 IEAMKNAHREEME-----RELEKSQRSQISSVNSDVEALRRQYLE---ELQSVQRELEVL 823
A ++ R E E +LE ++R Q +++ALR + E + + Q E E L
Sbjct: 1468 EAAERSRLRIEEEIRVVRLQLEATER-QRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1526
Query: 824 SEQY----SQKCLENAHLAQALEAERQALRQCQRENQ---ELNAHNQELNNRL-AAEITR 875
Q +K LA ++AE +A R+ QR Q EL +E RL AE+ R
Sbjct: 1527 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1586
Query: 876 LRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKK 935
R + + + Q K A E +++ S +Q ++ L++E + + +
Sbjct: 1587 ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS-LQEEHVAVAQLREEAERRAQQQA 1645
Query: 936 YASDKYKDIYTELSIAKAKADCDISRLK------EQLKAATEALGEKSPDSA 981
A ++ EL + KA+ + RL+ Q K+ +A EK + A
Sbjct: 1646 EAERAREEAERELERWQLKAN-EALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1696
Score = 51.6 bits (122), Expect = 4e-06
Identities = 102/476 (21%), Positives = 183/476 (38%), Gaps = 63/476 (13%)
Query: 513 EKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPL 572
E + A + E+ R +A + R + + + + AQ R A E L
Sbjct: 2109 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA---EKL 2165
Query: 573 RPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTH-- 630
R EAE R +A + R+K+ + + LR + L L+
Sbjct: 2166 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2225
Query: 631 ----NVHVEIEQRWHQVETTPLREEKQVP--IAPVHLSSEDGGDRLSTHELTS------- 677
N+ E QR T R+ QV + V + E+ + E +
Sbjct: 2226 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2285
Query: 678 ------LLEKELEQSQKEASDLLEQNRLLQDQLRVA-LGREQSAREGYVLQATCERGFAA 730
L++E E+ ++ A + + Q+ R+ L E A++ + + + A
Sbjct: 2286 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2345
Query: 731 MEETHQKKIEDLQRQHQREL-----EKLREEKDRL---LAEETAATISAIEAMKNAHREE 782
++E + K E Q Q+EL +L+E+K+++ LAEET +EA E
Sbjct: 2346 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA-------E 2398
Query: 783 MERELEKSQRSQISSVN-SDVEALRRQYLEELQSVQRELEVLSEQYSQKCL---ENAHLA 838
+R+LE S ++ + +++ + + E+ Q +++ E + E+ + L E L
Sbjct: 2399 RQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLV 2458
Query: 839 QALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKD 898
Q LE +RQ + H+ E AE+ R + L + + L Q K
Sbjct: 2459 QTLEIQRQQ-----------SDHDAERLREAIAELEREKEKLQQE-------AKLLQLKS 2500
Query: 899 AYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAK 954
V E Q L+Q S KD L R + K + ++ + +AKA+
Sbjct: 2501 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD-EVAKAQ 2555
Score = 50.1 bits (118), Expect = 1e-05
Identities = 87/360 (24%), Positives = 157/360 (43%), Gaps = 58/360 (16%)
Query: 531 ARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAE----PGELERERA 586
A+E R + D A+ R + + + +E++ V A L+ EAE EL +E+A
Sbjct: 2314 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR---LKAEAELLQQQKELAQEQA 2370
Query: 587 RRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMS-DLKTHNVHV-EIEQRWHQVE 644
RR +E +++ A + G + +E +R L MS + + + V E+ + + E
Sbjct: 2371 RRLQEDKEQMAQQLAEETQGFQRT---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2427
Query: 645 TTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQS---QKEASDLLEQNRLLQ 701
R KQ +E+ G++L EL + + L Q+ Q++ SD + RL +
Sbjct: 2428 EDAQRFRKQ---------AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLRE 2477
Query: 702 DQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLL 761
+ +E+ +E +LQ E M+ Q E L ++ Q + EKD LL
Sbjct: 2478 AIAELEREKEKLQQEAKLLQLKSEE----MQTVQQ---EQLLQETQALQQSFLSEKDSLL 2530
Query: 762 AEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELE 821
+ ER +E+ +++++ + D A +Q EE Q Q+++E
Sbjct: 2531 --------------------QRERFIEQ-EKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2569
Query: 822 VLSEQYSQKCLENAHLAQALEAE-RQALRQCQRENQELNAHNQELNNRLAAEITRLRTLL 880
Q Q+ + + A+ + E + +R+ Q E Q+L ++ LA E RLR L
Sbjct: 2570 ----QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2625
Score = 49.3 bits (116), Expect = 2e-05
Identities = 89/356 (25%), Positives = 152/356 (42%), Gaps = 30/356 (8%)
Query: 514 KQEAELGEPDPEQKRSRARERRREGRSKTFDWAE-FRPIQQALAQERVGGVGPADTHEPL 572
K EAEL + E + +AR + + AE + Q+ L ER + + E L
Sbjct: 2353 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2412
Query: 573 RPEAEPGELERERARRREERRK------RFG-MLDATDGPGTEDAAL--RMEVDRSPGLP 623
+ E+ R +AR E+ ++ G L T+ E L +E+ R
Sbjct: 2413 KLRV--AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2470
Query: 624 MSD-LKTHNVHVEIEQRWHQVETTPLR---EEKQVPIAPVHLSSEDGGDRLSTHELTSLL 679
++ L+ +E E+ Q E L+ EE Q L + E SLL
Sbjct: 2471 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2530
Query: 680 EKELEQSQKEASDLLEQNRLLQDQLRVALG-REQSAREGYVLQATCERGFAAMEETH--Q 736
++E Q++A LEQ L QD++ A RE+ R+ ++ +R A+MEE Q
Sbjct: 2531 QRERFIEQEKAK--LEQ--LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2586
Query: 737 KKIEDLQRQHQRELEKL---REEKDRLLAEETAATISAIEAMKNAHREEM--ERELEKSQ 791
+ E+ R+ Q EL++L R +++ LLAEE ++ ++ HR + E+ SQ
Sbjct: 2587 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2646
Query: 792 RSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQA 847
+ ++ + +AL E + + L + S + L+ A + A E +R A
Sbjct: 2647 VAATKTLPNGRDALDGPAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2700
Score = 47.4 bits (111), Expect = 7e-05
Identities = 63/316 (19%), Positives = 138/316 (43%), Gaps = 30/316 (9%)
Query: 676 TSLLEKELEQS------QKEASD----LLEQNRLLQDQLR-VALGREQSAREGYVLQATC 724
T + ++ELEQ +E++D L+ R Q+Q++ + L Q+ RE Q
Sbjct: 1222 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE----QLRQ 1277
Query: 725 ERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEME 784
E+ E H +K+E+ QR ++ + +++ + +L+ + A A K + E
Sbjct: 1278 EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1337
Query: 785 RELEKSQRSQISSVNSDVEALRRQYL----EELQSVQRELEVLSEQYSQKCLENAHLAQA 840
++ + + + S++ L QY+ E L+ ++ E + +Q +++ A + A
Sbjct: 1338 SVIQ--EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAA 1395
Query: 841 LEAERQALRQCQRENQELNAHNQELNNRLAAEITRL-RTLLTGDGGGEATGSPLAQGKDA 899
LE +RQ + + +EL R+ E+ R + + L Q + +
Sbjct: 1396 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS 1455
Query: 900 YELEVLLRVKESEIQ-----YLKQEISSLKDELQTALRDKKYASDKYKDIYT---ELSIA 951
E E+ + +++E +++EI ++ +L+ R + A + + + E
Sbjct: 1456 SEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1515
Query: 952 KAKADCDISRLKEQLK 967
K +A + RL+ Q++
Sbjct: 1516 KRQAQEEAERLRRQVQ 1531
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 72.4 bits (176), Expect = 2e-12
Identities = 113/464 (24%), Positives = 203/464 (43%), Gaps = 59/464 (12%)
Query: 526 QKRSRARERRREGRSKTFDWAEFRPIQQALAQ----ERVGGVGPADTHEPLRPEAEPG-- 579
++R RA RE +K A R +++AL ER AD + + + + G
Sbjct: 1469 EERDRAEAEAREKETKALSLA--RALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKN 1526
Query: 580 --ELER-ERARRREERRKRFGMLDATDG-PGTEDAALRMEVDRSPGLPMSDLKTHNVHVE 635
ELE+ +RA ++ R + + D TEDA LR+EV+ M +K +
Sbjct: 1527 VHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVN------MQAMKAQ-FERD 1579
Query: 636 IEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSL------LEKELEQSQKE 689
++ R Q E KQV L E L+ + LE ++E + K
Sbjct: 1580 LQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKA 1639
Query: 690 ASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRE 749
++++Q R LQ Q++ + AR A+ + FA +E+ +KK++ L+ E
Sbjct: 1640 RDEVIKQLRKLQAQMKDYQRELEEAR------ASRDEIFAQSKES-EKKLKSLEA----E 1688
Query: 750 LEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQ--RSQISSVNSDVEALRR 807
+ +L+EE L + E A + E R+E+ E+ S +S + +EA
Sbjct: 1689 ILQLQEE---LASSERARRHAEQE------RDELADEITNSASGKSALLDEKRRLEARIA 1739
Query: 808 QYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNN 867
Q EEL+ Q +E+L++++ + L+ L L AER A ++ Q+L N+EL
Sbjct: 1740 QLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELK- 1798
Query: 868 RLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDEL 927
A++ L + + G+ +LE + + + + +++ LK E+
Sbjct: 1799 ---AKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLK-EI 1854
Query: 928 QTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATE 971
+ D++ +D+YK+ KA+ + +LK QL+ A E
Sbjct: 1855 FMQVEDERRHADQYKE-------QMEKANARMKQLKRQLEEAEE 1891
Score = 63.2 bits (152), Expect = 1e-09
Identities = 79/360 (21%), Positives = 157/360 (43%), Gaps = 28/360 (7%)
Query: 636 IEQRWHQVETTPLREEKQVPIAPVHLSS--EDGGDRLSTHELTSLLEKELEQSQKEASDL 693
++++ + E EKQV L+ + D L T E +K+L + + S
Sbjct: 1348 LQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQR 1407
Query: 694 LEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKL 753
LE+ L D+L R Q + + +R A+ E QKK + L + + +
Sbjct: 1408 LEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARY 1467
Query: 754 REEKDRLLAE----ETAATISAIEAMKNA--HREEMERELEK---------SQRSQISSV 798
EE+DR AE ET A +S A++ A +EE ER+ ++ S + +
Sbjct: 1468 AEERDRAEAEAREKETKA-LSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKN 1526
Query: 799 NSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALR-QCQRENQE 857
++E +R ++++ ++ +LE L ++ + E+A L LE QA++ Q +R+ Q
Sbjct: 1527 VHELEKSKRALEQQVEEMRTQLEELEDEL--QATEDAKL--RLEVNMQAMKAQFERDLQT 1582
Query: 858 LNAHNQELNNRLAAEITRLRTLLTGDGGGE--ATGSPLAQGKDAYELEVLLRVKESEIQY 915
+ N+E L ++ L L + A S D +LE +
Sbjct: 1583 RDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDE 1642
Query: 916 LKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAK---ADCDISRLKEQLKAATEA 972
+ +++ L+ +++ R+ + A +I+ + ++ K + +I +L+E+L ++ A
Sbjct: 1643 VIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERA 1702
Score = 53.5 bits (127), Expect = 1e-06
Identities = 83/422 (19%), Positives = 180/422 (42%), Gaps = 48/422 (11%)
Query: 639 RWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNR 698
+W +V T ++ QV L ++D + L E + +E ELE+ +++ LLE+
Sbjct: 833 QWWRV-FTKVKPLLQVTRQEEELQAKDE-ELLKVKEKQTKVEGELEEMERKHQQLLEEKN 890
Query: 699 LLQDQLRV-----ALGREQSAREGYVLQATCE-----RGFAAMEETHQKKIEDLQRQHQR 748
+L +QL+ A E AR Q E EE + +++ +++ Q
Sbjct: 891 ILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQA 950
Query: 749 ELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQ 808
++ L E+ D + + A + E E L + Q S+ +E +
Sbjct: 951 HIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAE 1010
Query: 809 YLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNR 868
+L + + + L++ +++ + + L + L+ E + ++ ++ ++L+ +L ++
Sbjct: 1011 CSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQ 1070
Query: 869 LA---AEITRLRTLLTGDGGGEATGSPLAQGKD--AYELEVLLRVKE--SEIQYLKQEIS 921
+A A+I L+ L E LA+G D ++ L V+E ++I L+++
Sbjct: 1071 IAELQAQIDELKLQLAKK--EEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFE 1128
Query: 922 SLKDELQTALRDKKYASDKYKDIYTELSIA----------KAKADCDISRLKEQLKAATE 971
S K A + K+ S++ + + TEL + K + +++ LK+ L+ T+
Sbjct: 1129 SEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK 1188
Query: 972 ---------------ALGEKSPDSATVSGY--DIMKSKSNPDFLKKDRSCVTRQLRNIRS 1014
AL E S + ++ K+K + K+ +C + L+ +++
Sbjct: 1189 NHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKA 1248
Query: 1015 KS 1016
+S
Sbjct: 1249 ES 1250
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 71.6 bits (174), Expect = 3e-12
Identities = 116/482 (24%), Positives = 207/482 (42%), Gaps = 50/482 (10%)
Query: 525 EQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGEL--E 582
E++R+ A R RE R+ + A + ER A+ L + + G+ E
Sbjct: 1495 ERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHE 1554
Query: 583 RERARRREERRKRFGMLDATDGP----GTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQ 638
ERA R E+ T+ EDA LR+EV + LKT + +++
Sbjct: 1555 LERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVT------VQALKTQHER-DLQG 1607
Query: 639 RWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNR 698
R E + KQ+ A V E+ R LE ELE+ + + +
Sbjct: 1608 RDEAGEERRRQLAKQLRDAEVE-RDEERKQRTLAVAARKKLEGELEELKAQMAS------ 1660
Query: 699 LLQDQLRVALGREQSAREGYVLQATCERGFAAMEETH--QKKIEDLQRQHQRELEKLREE 756
G+E++ ++ +QA + + +EET +++I R+ ++ L+ L E
Sbjct: 1661 -------AGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE 1713
Query: 757 KDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNS--DVEALRRQYLEELQ 814
RL E A+ + +A ++ R+EM E+ S+ + + +E Q EEL+
Sbjct: 1714 VLRLQEELAASDRARRQAQQD--RDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELE 1771
Query: 815 SVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEI- 873
Q E+L+++Y + L+ L L AER + + Q+L QEL RL E
Sbjct: 1772 EEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDA 1831
Query: 874 -TRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEI-----QYLKQEISSLKDEL 927
R R +T A S LAQ ++ E E R+ ++ + LK+ + +++E
Sbjct: 1832 GARARHKMT----IAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEER 1887
Query: 928 QTA--LRDK-KYASDKYKDIYTELSIAK---AKADCDISRLKEQLKAATEALGEKSPDSA 981
+ A LRD+ + + + K + +L A+ ++A RL+ +L+ TE+ + +
Sbjct: 1888 RVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVT 1947
Query: 982 TV 983
T+
Sbjct: 1948 TL 1949
Score = 63.2 bits (152), Expect = 1e-09
Identities = 90/421 (21%), Positives = 170/421 (40%), Gaps = 63/421 (14%)
Query: 575 EAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHV 634
+ G+ ER RA E+ ++ L+ G E + + + + L ++ + H+
Sbjct: 1290 QGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKE--LSSTEAQLHDAQE 1347
Query: 635 EIEQ------------RWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKE 682
+++ R + E LRE+ + A + E G L T + E
Sbjct: 1348 LLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAA----ARERAGRELQTAQAQL---SE 1400
Query: 683 LEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQAT-----CERGFAAMEETHQK 737
+ Q+E + LE ++ R RE A + + T ERG +++
Sbjct: 1401 WRRRQEEEAGALEAG----EEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDD 1456
Query: 738 KIEDLQRQHQ--RELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQI 795
DL++Q Q LEK + + D+LLAEE AA + A+E + A E ERE ++ +
Sbjct: 1457 ATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE---ARALSL 1513
Query: 796 SSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQREN 855
+ + + R + + ++++ ELE L + +++ +A R ++
Sbjct: 1514 TRALEEEQEAREELERQNRALRAELEALLSSKDD-------VGKSVHELERACRVAEQAA 1566
Query: 856 QELNAHNQELNNRL-AAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQ 914
+L A EL + L AAE +LR +T ++ L E ++Q
Sbjct: 1567 NDLRAQVTELEDELTAAEDAKLRLEVT--------------------VQALKTQHERDLQ 1606
Query: 915 YLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEALG 974
+ + +L LRD + D+ + T A+ K + ++ LK Q+ +A +
Sbjct: 1607 GRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKE 1666
Query: 975 E 975
E
Sbjct: 1667 E 1667
Score = 48.1 bits (113), Expect = 4e-05
Identities = 79/309 (25%), Positives = 129/309 (41%), Gaps = 35/309 (11%)
Query: 650 EEKQVPIAPVHLSSE----DGGDRLSTHEL-TSLLEKELEQSQKEASDLLEQ---NRLLQ 701
EEK + + L E D DRL E LEK + E+S+L EQ +
Sbjct: 1044 EEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRA 1103
Query: 702 DQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLR------E 755
++LR LGR++ + + +A E G A ++ + + Q +LE R E
Sbjct: 1104 EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAE 1163
Query: 756 EKDRLLAEETAA-------TISAIEAMK--NAHREEMERELEKSQRSQISSVNSDVEALR 806
++ R L EE A T+ + A + + RE+ EL+K+ + + V+ LR
Sbjct: 1164 KQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELR 1223
Query: 807 RQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELN 866
+++ + L + +LE + + E L ALEAE LR E L QE
Sbjct: 1224 QRHGQALGELAEQLE--QARRGKGAWEKTRL--ALEAEVSELR---AELSSLQTARQEGE 1276
Query: 867 NRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEV-----LLRVKESEIQYLKQEIS 921
R +L+ + G GE + A+ + E+ L ES+ L +E+S
Sbjct: 1277 QRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELS 1336
Query: 922 SLKDELQTA 930
S + +L A
Sbjct: 1337 STEAQLHDA 1345
Score = 44.3 bits (103), Expect = 6e-04
Identities = 68/337 (20%), Positives = 136/337 (40%), Gaps = 36/337 (10%)
Query: 642 QVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQ 701
Q L EE+ + +E + T + ++ELE E + +
Sbjct: 904 QGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECS 963
Query: 702 DQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREE----- 756
Q++ R Q + E G + + E ++ + +L L ++
Sbjct: 964 RQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLS 1023
Query: 757 KDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQY--LEELQ 814
K+R L E+ A S+ + A EE + L K + +++ + LR++ +EL+
Sbjct: 1024 KERKLLEDRLAEFSS----QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELE 1079
Query: 815 SVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEIT 874
++R L+ S + ++ +E A+ L A Q R+ +EL A + A
Sbjct: 1080 KLKRRLDGESSELQEQMVEQQQRAEELRA------QLGRKEEELQAALARAEDEGGARAQ 1133
Query: 875 RLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVK-ESEIQYLKQEISSLKDELQTALRD 933
L++L + LA+ ++ E E + R K E + + L +E+ +L+ EL+ L D
Sbjct: 1134 LLKSL-------REAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTL-D 1185
Query: 934 KKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAAT 970
A + ++K + +++ LK+ L+ T
Sbjct: 1186 STNAQQE----------LRSKREQEVTELKKTLEEET 1212
Score = 39.3 bits (90), Expect = 0.019
Identities = 79/356 (22%), Positives = 140/356 (39%), Gaps = 73/356 (20%)
Query: 712 QSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRE-------LEKLREEKDRLL--- 761
Q R+ VLQA + +K+++LQ+Q RE + +L EE+ RL
Sbjct: 871 QVTRQDEVLQARAQE---------LQKVQELQQQSAREVGELQGRVAQLEEERARLAEQL 921
Query: 762 ---------AEETAA-----------TISAIEA-----------------MKNAHREEME 784
AEET +S +EA H +E+E
Sbjct: 922 RAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELE 981
Query: 785 RELEKSQ--RSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLEN--AHLAQA 840
LE + R ++ EA +++ E+L ++ + LS++ +K LE+ A +
Sbjct: 982 AHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKE--RKLLEDRLAEFSSQ 1039
Query: 841 LEAERQALRQCQRENQELNAHNQELNNRL------AAEITRLRTLLTGDGGGEATGSPLA 894
E + ++ + + A ++ +RL E+ +L+ L G+ E +
Sbjct: 1040 AAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGE-SSELQEQMVE 1098
Query: 895 QGKDAYELEVLLRVKESEIQYL---KQEISSLKDELQTALRDKKYASDKYKDIYTELSIA 951
Q + A EL L KE E+Q ++ + +L +LR+ + A + ++ +A
Sbjct: 1099 QQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVA 1158
Query: 952 KAKADCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTR 1007
+ KA+ L E+L+A L E + DS K + LKK TR
Sbjct: 1159 RTKAEKQRRDLGEELEALRGEL-EDTLDSTNAQQELRSKREQEVTELKKTLEEETR 1213
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 71.6 bits (174), Expect = 3e-12
Identities = 116/482 (24%), Positives = 207/482 (42%), Gaps = 50/482 (10%)
Query: 525 EQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGEL--E 582
E++R+ A R RE R+ + A + ER A+ L + + G+ E
Sbjct: 1487 ERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHE 1546
Query: 583 RERARRREERRKRFGMLDATDGP----GTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQ 638
ERA R E+ T+ EDA LR+EV + LKT + +++
Sbjct: 1547 LERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVT------VQALKTQHER-DLQG 1599
Query: 639 RWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNR 698
R E + KQ+ A V E+ R LE ELE+ + + +
Sbjct: 1600 RDEAGEERRRQLAKQLRDAEVE-RDEERKQRTLAVAARKKLEGELEELKAQMAS------ 1652
Query: 699 LLQDQLRVALGREQSAREGYVLQATCERGFAAMEETH--QKKIEDLQRQHQRELEKLREE 756
G+E++ ++ +QA + + +EET +++I R+ ++ L+ L E
Sbjct: 1653 -------AGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE 1705
Query: 757 KDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNS--DVEALRRQYLEELQ 814
RL E A+ + +A ++ R+EM E+ S+ + + +E Q EEL+
Sbjct: 1706 VLRLQEELAASDRARRQAQQD--RDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELE 1763
Query: 815 SVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEI- 873
Q E+L+++Y + L+ L L AER + + Q+L QEL RL E
Sbjct: 1764 EEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDA 1823
Query: 874 -TRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEI-----QYLKQEISSLKDEL 927
R R +T A S LAQ ++ E E R+ ++ + LK+ + +++E
Sbjct: 1824 GARARHKMT----IAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEER 1879
Query: 928 QTA--LRDK-KYASDKYKDIYTELSIAK---AKADCDISRLKEQLKAATEALGEKSPDSA 981
+ A LRD+ + + + K + +L A+ ++A RL+ +L+ TE+ + +
Sbjct: 1880 RVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVT 1939
Query: 982 TV 983
T+
Sbjct: 1940 TL 1941
Score = 63.2 bits (152), Expect = 1e-09
Identities = 90/421 (21%), Positives = 170/421 (40%), Gaps = 63/421 (14%)
Query: 575 EAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHV 634
+ G+ ER RA E+ ++ L+ G E + + + + L ++ + H+
Sbjct: 1282 QGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKE--LSSTEAQLHDAQE 1339
Query: 635 EIEQ------------RWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKE 682
+++ R + E LRE+ + A + E G L T + E
Sbjct: 1340 LLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAA----ARERAGRELQTAQAQL---SE 1392
Query: 683 LEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQAT-----CERGFAAMEETHQK 737
+ Q+E + LE ++ R RE A + + T ERG +++
Sbjct: 1393 WRRRQEEEAGALEAG----EEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDD 1448
Query: 738 KIEDLQRQHQ--RELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQI 795
DL++Q Q LEK + + D+LLAEE AA + A+E + A E ERE ++ +
Sbjct: 1449 ATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE---ARALSL 1505
Query: 796 SSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQREN 855
+ + + R + + ++++ ELE L + +++ +A R ++
Sbjct: 1506 TRALEEEQEAREELERQNRALRAELEALLSSKDD-------VGKSVHELERACRVAEQAA 1558
Query: 856 QELNAHNQELNNRL-AAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQ 914
+L A EL + L AAE +LR +T ++ L E ++Q
Sbjct: 1559 NDLRAQVTELEDELTAAEDAKLRLEVT--------------------VQALKTQHERDLQ 1598
Query: 915 YLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEALG 974
+ + +L LRD + D+ + T A+ K + ++ LK Q+ +A +
Sbjct: 1599 GRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKE 1658
Query: 975 E 975
E
Sbjct: 1659 E 1659
Score = 48.1 bits (113), Expect = 4e-05
Identities = 79/309 (25%), Positives = 129/309 (41%), Gaps = 35/309 (11%)
Query: 650 EEKQVPIAPVHLSSE----DGGDRLSTHEL-TSLLEKELEQSQKEASDLLEQ---NRLLQ 701
EEK + + L E D DRL E LEK + E+S+L EQ +
Sbjct: 1036 EEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRA 1095
Query: 702 DQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLR------E 755
++LR LGR++ + + +A E G A ++ + + Q +LE R E
Sbjct: 1096 EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAE 1155
Query: 756 EKDRLLAEETAA-------TISAIEAMK--NAHREEMERELEKSQRSQISSVNSDVEALR 806
++ R L EE A T+ + A + + RE+ EL+K+ + + V+ LR
Sbjct: 1156 KQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELR 1215
Query: 807 RQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELN 866
+++ + L + +LE + + E L ALEAE LR E L QE
Sbjct: 1216 QRHGQALGELAEQLE--QARRGKGAWEKTRL--ALEAEVSELR---AELSSLQTARQEGE 1268
Query: 867 NRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEV-----LLRVKESEIQYLKQEIS 921
R +L+ + G GE + A+ + E+ L ES+ L +E+S
Sbjct: 1269 QRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELS 1328
Query: 922 SLKDELQTA 930
S + +L A
Sbjct: 1329 STEAQLHDA 1337
Score = 44.3 bits (103), Expect = 6e-04
Identities = 68/337 (20%), Positives = 136/337 (40%), Gaps = 36/337 (10%)
Query: 642 QVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQ 701
Q L EE+ + +E + T + ++ELE E + +
Sbjct: 896 QGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECS 955
Query: 702 DQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREE----- 756
Q++ R Q + E G + + E ++ + +L L ++
Sbjct: 956 RQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLS 1015
Query: 757 KDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQY--LEELQ 814
K+R L E+ A S+ + A EE + L K + +++ + LR++ +EL+
Sbjct: 1016 KERKLLEDRLAEFSS----QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELE 1071
Query: 815 SVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEIT 874
++R L+ S + ++ +E A+ L A Q R+ +EL A + A
Sbjct: 1072 KLKRRLDGESSELQEQMVEQQQRAEELRA------QLGRKEEELQAALARAEDEGGARAQ 1125
Query: 875 RLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVK-ESEIQYLKQEISSLKDELQTALRD 933
L++L + LA+ ++ E E + R K E + + L +E+ +L+ EL+ L D
Sbjct: 1126 LLKSL-------REAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTL-D 1177
Query: 934 KKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAAT 970
A + ++K + +++ LK+ L+ T
Sbjct: 1178 STNAQQE----------LRSKREQEVTELKKTLEEET 1204
Score = 39.3 bits (90), Expect = 0.019
Identities = 79/356 (22%), Positives = 140/356 (39%), Gaps = 73/356 (20%)
Query: 712 QSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRE-------LEKLREEKDRLL--- 761
Q R+ VLQA + +K+++LQ+Q RE + +L EE+ RL
Sbjct: 863 QVTRQDEVLQARAQE---------LQKVQELQQQSAREVGELQGRVAQLEEERARLAEQL 913
Query: 762 ---------AEETAA-----------TISAIEA-----------------MKNAHREEME 784
AEET +S +EA H +E+E
Sbjct: 914 RAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELE 973
Query: 785 RELEKSQ--RSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLEN--AHLAQA 840
LE + R ++ EA +++ E+L ++ + LS++ +K LE+ A +
Sbjct: 974 AHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKE--RKLLEDRLAEFSSQ 1031
Query: 841 LEAERQALRQCQRENQELNAHNQELNNRL------AAEITRLRTLLTGDGGGEATGSPLA 894
E + ++ + + A ++ +RL E+ +L+ L G+ E +
Sbjct: 1032 AAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGE-SSELQEQMVE 1090
Query: 895 QGKDAYELEVLLRVKESEIQYL---KQEISSLKDELQTALRDKKYASDKYKDIYTELSIA 951
Q + A EL L KE E+Q ++ + +L +LR+ + A + ++ +A
Sbjct: 1091 QQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVA 1150
Query: 952 KAKADCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTR 1007
+ KA+ L E+L+A L E + DS K + LKK TR
Sbjct: 1151 RTKAEKQRRDLGEELEALRGEL-EDTLDSTNAQQELRSKREQEVTELKKTLEEETR 1205
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 71.6 bits (174), Expect = 3e-12
Identities = 116/482 (24%), Positives = 207/482 (42%), Gaps = 50/482 (10%)
Query: 525 EQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGEL--E 582
E++R+ A R RE R+ + A + ER A+ L + + G+ E
Sbjct: 1528 ERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHE 1587
Query: 583 RERARRREERRKRFGMLDATDGP----GTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQ 638
ERA R E+ T+ EDA LR+EV + LKT + +++
Sbjct: 1588 LERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVT------VQALKTQHER-DLQG 1640
Query: 639 RWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNR 698
R E + KQ+ A V E+ R LE ELE+ + + +
Sbjct: 1641 RDEAGEERRRQLAKQLRDAEVE-RDEERKQRTLAVAARKKLEGELEELKAQMAS------ 1693
Query: 699 LLQDQLRVALGREQSAREGYVLQATCERGFAAMEETH--QKKIEDLQRQHQRELEKLREE 756
G+E++ ++ +QA + + +EET +++I R+ ++ L+ L E
Sbjct: 1694 -------AGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE 1746
Query: 757 KDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNS--DVEALRRQYLEELQ 814
RL E A+ + +A ++ R+EM E+ S+ + + +E Q EEL+
Sbjct: 1747 VLRLQEELAASDRARRQAQQD--RDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELE 1804
Query: 815 SVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEI- 873
Q E+L+++Y + L+ L L AER + + Q+L QEL RL E
Sbjct: 1805 EEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDA 1864
Query: 874 -TRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEI-----QYLKQEISSLKDEL 927
R R +T A S LAQ ++ E E R+ ++ + LK+ + +++E
Sbjct: 1865 GARARHKMT----IAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEER 1920
Query: 928 QTA--LRDK-KYASDKYKDIYTELSIAK---AKADCDISRLKEQLKAATEALGEKSPDSA 981
+ A LRD+ + + + K + +L A+ ++A RL+ +L+ TE+ + +
Sbjct: 1921 RVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVT 1980
Query: 982 TV 983
T+
Sbjct: 1981 TL 1982
Score = 63.2 bits (152), Expect = 1e-09
Identities = 90/421 (21%), Positives = 170/421 (40%), Gaps = 63/421 (14%)
Query: 575 EAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHV 634
+ G+ ER RA E+ ++ L+ G E + + + + L ++ + H+
Sbjct: 1323 QGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKE--LSSTEAQLHDAQE 1380
Query: 635 EIEQ------------RWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKE 682
+++ R + E LRE+ + A + E G L T + E
Sbjct: 1381 LLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAA----ARERAGRELQTAQAQL---SE 1433
Query: 683 LEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQAT-----CERGFAAMEETHQK 737
+ Q+E + LE ++ R RE A + + T ERG +++
Sbjct: 1434 WRRRQEEEAGALEAG----EEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDD 1489
Query: 738 KIEDLQRQHQ--RELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQI 795
DL++Q Q LEK + + D+LLAEE AA + A+E + A E ERE ++ +
Sbjct: 1490 ATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE---ARALSL 1546
Query: 796 SSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQREN 855
+ + + R + + ++++ ELE L + +++ +A R ++
Sbjct: 1547 TRALEEEQEAREELERQNRALRAELEALLSSKDD-------VGKSVHELERACRVAEQAA 1599
Query: 856 QELNAHNQELNNRL-AAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQ 914
+L A EL + L AAE +LR +T ++ L E ++Q
Sbjct: 1600 NDLRAQVTELEDELTAAEDAKLRLEVT--------------------VQALKTQHERDLQ 1639
Query: 915 YLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEALG 974
+ + +L LRD + D+ + T A+ K + ++ LK Q+ +A +
Sbjct: 1640 GRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKE 1699
Query: 975 E 975
E
Sbjct: 1700 E 1700
Score = 48.1 bits (113), Expect = 4e-05
Identities = 79/309 (25%), Positives = 129/309 (41%), Gaps = 35/309 (11%)
Query: 650 EEKQVPIAPVHLSSE----DGGDRLSTHEL-TSLLEKELEQSQKEASDLLEQ---NRLLQ 701
EEK + + L E D DRL E LEK + E+S+L EQ +
Sbjct: 1077 EEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRA 1136
Query: 702 DQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLR------E 755
++LR LGR++ + + +A E G A ++ + + Q +LE R E
Sbjct: 1137 EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAE 1196
Query: 756 EKDRLLAEETAA-------TISAIEAMK--NAHREEMERELEKSQRSQISSVNSDVEALR 806
++ R L EE A T+ + A + + RE+ EL+K+ + + V+ LR
Sbjct: 1197 KQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELR 1256
Query: 807 RQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELN 866
+++ + L + +LE + + E L ALEAE LR E L QE
Sbjct: 1257 QRHGQALGELAEQLE--QARRGKGAWEKTRL--ALEAEVSELR---AELSSLQTARQEGE 1309
Query: 867 NRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEV-----LLRVKESEIQYLKQEIS 921
R +L+ + G GE + A+ + E+ L ES+ L +E+S
Sbjct: 1310 QRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELS 1369
Query: 922 SLKDELQTA 930
S + +L A
Sbjct: 1370 STEAQLHDA 1378
Score = 44.3 bits (103), Expect = 6e-04
Identities = 68/337 (20%), Positives = 136/337 (40%), Gaps = 36/337 (10%)
Query: 642 QVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQ 701
Q L EE+ + +E + T + ++ELE E + +
Sbjct: 937 QGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECS 996
Query: 702 DQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREE----- 756
Q++ R Q + E G + + E ++ + +L L ++
Sbjct: 997 RQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLS 1056
Query: 757 KDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQY--LEELQ 814
K+R L E+ A S+ + A EE + L K + +++ + LR++ +EL+
Sbjct: 1057 KERKLLEDRLAEFSS----QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELE 1112
Query: 815 SVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEIT 874
++R L+ S + ++ +E A+ L A Q R+ +EL A + A
Sbjct: 1113 KLKRRLDGESSELQEQMVEQQQRAEELRA------QLGRKEEELQAALARAEDEGGARAQ 1166
Query: 875 RLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVK-ESEIQYLKQEISSLKDELQTALRD 933
L++L + LA+ ++ E E + R K E + + L +E+ +L+ EL+ L D
Sbjct: 1167 LLKSL-------REAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTL-D 1218
Query: 934 KKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAAT 970
A + ++K + +++ LK+ L+ T
Sbjct: 1219 STNAQQE----------LRSKREQEVTELKKTLEEET 1245
Score = 39.3 bits (90), Expect = 0.019
Identities = 79/356 (22%), Positives = 140/356 (39%), Gaps = 73/356 (20%)
Query: 712 QSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRE-------LEKLREEKDRLL--- 761
Q R+ VLQA + +K+++LQ+Q RE + +L EE+ RL
Sbjct: 904 QVTRQDEVLQARAQE---------LQKVQELQQQSAREVGELQGRVAQLEEERARLAEQL 954
Query: 762 ---------AEETAA-----------TISAIEA-----------------MKNAHREEME 784
AEET +S +EA H +E+E
Sbjct: 955 RAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELE 1014
Query: 785 RELEKSQ--RSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLEN--AHLAQA 840
LE + R ++ EA +++ E+L ++ + LS++ +K LE+ A +
Sbjct: 1015 AHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKE--RKLLEDRLAEFSSQ 1072
Query: 841 LEAERQALRQCQRENQELNAHNQELNNRL------AAEITRLRTLLTGDGGGEATGSPLA 894
E + ++ + + A ++ +RL E+ +L+ L G+ E +
Sbjct: 1073 AAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGE-SSELQEQMVE 1131
Query: 895 QGKDAYELEVLLRVKESEIQYL---KQEISSLKDELQTALRDKKYASDKYKDIYTELSIA 951
Q + A EL L KE E+Q ++ + +L +LR+ + A + ++ +A
Sbjct: 1132 QQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVA 1191
Query: 952 KAKADCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTR 1007
+ KA+ L E+L+A L E + DS K + LKK TR
Sbjct: 1192 RTKAEKQRRDLGEELEALRGEL-EDTLDSTNAQQELRSKREQEVTELKKTLEEETR 1246
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 69.3 bits (168), Expect = 2e-11
Identities = 84/362 (23%), Positives = 154/362 (42%), Gaps = 42/362 (11%)
Query: 679 LEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKK 738
L +L++ +E DL ++ L D + A + + A E + Q C G M++ +
Sbjct: 1235 LRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKAC--GSEIMQKKQHLE 1292
Query: 739 IEDLQRQHQRELEKLREEKDRLLAEETAATIS----AIEAMKNAHREEMERELE-KSQRS 793
IE Q QR + R ++ EE A TI IE +K +EE +R E +++ S
Sbjct: 1293 IELKQVMQQRSEDNARHKQS---LEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELS 1349
Query: 794 QI-SSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQ 852
++ ++ + ++ +L+ Q+ E+ + + L+ Q + R +
Sbjct: 1350 KVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDT----------SGYRAQIDNLT 1399
Query: 853 RENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEV----LLRV 908
REN+ L+ + L N L LR + +ATGS ++Q K E+E+ +R
Sbjct: 1400 RENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRT 1459
Query: 909 KES------------EIQYLKQEISSLKDELQTALRDKKYASD---KYKDIYTELSIAKA 953
+ES IQ +EI LK + D+K D + + + +L A +
Sbjct: 1460 EESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANS 1519
Query: 954 KADCDISRLKEQLKAATEAL--GEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRN 1011
A I++LK Q + T E+ TV DI + +++ L+ + V +L
Sbjct: 1520 SATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNR 1579
Query: 1012 IR 1013
++
Sbjct: 1580 LK 1581
Score = 52.0 bits (123), Expect = 3e-06
Identities = 74/330 (22%), Positives = 146/330 (44%), Gaps = 46/330 (13%)
Query: 661 LSSEDGGDRLSTHELTSLLEK---ELEQSQKEASDLLEQNRLLQDQL-RVALGREQSARE 716
L ++ DR + + L++ +L+++ A++ + + ++ + +L R+ + E+ ++E
Sbjct: 1489 LIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQE 1548
Query: 717 GYVLQATCERGFAAMEETH---QKKIEDLQRQHQRELE------KLREEKD---RLLAEE 764
V R +++E QK E+L R + E KL EE + R L E+
Sbjct: 1549 RTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQ 1608
Query: 765 TAATISAIEAMKNA-------------HREEMERELEKSQRSQ--ISSVNSDVEALRRQY 809
+ + ++ A R+ ++ L + QR+Q + ++S+VEALRRQ
Sbjct: 1609 AIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQL 1668
Query: 810 LEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRL 869
L+E +SV+ Q L N H +A+E + ++L + + E + L + + L
Sbjct: 1669 LQEQESVK-----------QAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEH 1717
Query: 870 AAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQT 929
LR L S K+A LE+ +++ S + L E+ L ++LQ
Sbjct: 1718 LMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTL--ELQGLINDLQR 1775
Query: 930 ALRDKKYASDKYKDIYTELS--IAKAKADC 957
+ + +K++ E S I ++K C
Sbjct: 1776 ERENLRQEIEKFQKQALEASNRIQESKNQC 1805
Score = 45.1 bits (105), Expect = 4e-04
Identities = 86/413 (20%), Positives = 181/413 (43%), Gaps = 55/413 (13%)
Query: 635 EIEQRW-HQVETTPLREEKQVPIAPV--HLSSEDGGDRLSTHELTSLLEKELEQSQKEAS 691
E ++RW ++ E + +R I + +E + + H+LT E++ + +
Sbjct: 1337 EAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQID 1396
Query: 692 DLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKI---EDLQRQHQR 748
+L +NR L ++++ R L T E E+ Q+K E QR+ Q
Sbjct: 1397 NLTRENRSLSEEIK---------RLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQL 1447
Query: 749 ELE-----KLREEKD---RLLAEETAATI----SAIEAMKN-AHREEMERELEKSQRSQI 795
E+E ++R E+ + ++ A TI IE +K +E +R+ + + +++
Sbjct: 1448 EVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARL 1507
Query: 796 SSVNSDVE---ALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQ 852
V D++ + + + +L+ ++EL L Y + E Q + + +L++ Q
Sbjct: 1508 QRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQ 1567
Query: 853 RENQELNAHNQELN--NRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKE 910
+ Q++ +ELN R A+E + R L E G + + A ++ L + E
Sbjct: 1568 LQKQKV---EEELNRLKRTASEDSCKRKKLE----EELEGMRRSLKEQAIKITNLTQQLE 1620
Query: 911 SEIQYLKQ---EISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLK 967
K+ ++ +D L LR+K+ ++ + + +E+ + + + + +E +K
Sbjct: 1621 QASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQ----LLQEQESVK 1676
Query: 968 AA-------TEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIR 1013
A +A+ +KS S S +I + +S + L K+ + +LRN+R
Sbjct: 1677 QAHLRNEHFQKAIEDKS-RSLNESKIEIERLQSLTENLTKEHLMLEEELRNLR 1728
Score = 42.4 bits (98), Expect = 0.002
Identities = 61/250 (24%), Positives = 106/250 (42%), Gaps = 39/250 (15%)
Query: 682 ELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIED 741
E+E+ Q +L +++ +L+++LR R G +A ++ +E Q +I +
Sbjct: 1702 EIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRS-EADSDKNATILELRSQLQISN 1760
Query: 742 --------LQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERE------- 786
L QRE E LR+E ++ + A+ E+ + ERE
Sbjct: 1761 NRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIK 1820
Query: 787 -LEKSQ------RSQISSVNSDVEALRR--QYLE-ELQSVQRELEVLSEQYSQKCLENAH 836
LE+ + +++ S +EA R Q LE E Q +Q +L QYS+K
Sbjct: 1821 VLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRK----EE 1876
Query: 837 LAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRL--RTLLTGDGGGEATGSPLA 894
+ +E+ER ++ +E N+ E+ RL AEI R+ R + T S L
Sbjct: 1877 AIRKIESER------EKSEREKNSLRSEI-ERLQAEIKRIEERCRRKLEDSTRETQSQLE 1929
Query: 895 QGKDAYELEV 904
+ Y+ E+
Sbjct: 1930 TERSRYQREI 1939
Score = 39.3 bits (90), Expect = 0.019
Identities = 46/197 (23%), Positives = 94/197 (47%), Gaps = 18/197 (9%)
Query: 679 LEKELEQSQKEASDLLEQNRLLQDQLRVALGRE----QSAREGYVLQATCERG--FAAME 732
LE+E E K + + ++ R LQ+ ++ A RE E +L ++ A +
Sbjct: 251 LEEEYENLLKASFERMDHLRQLQNIIQ-ATSREIMWINDCEEEELLYDWSDKNTNIAQKQ 309
Query: 733 ETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQR 792
E ++ L+ + ++EL KL++E D+L+ + A+ IEA + + + L Q
Sbjct: 310 EAFSIRMSQLEVK-EKELNKLKQESDQLVLNQHPAS-DKIEAYMDTLQTQWSWIL---QI 364
Query: 793 SQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQK--CLENAHLAQALEAERQALRQ 850
++ V+ A Q+ EE QS + L+ L + +K C +N L LE +++
Sbjct: 365 TKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLE----QIKE 420
Query: 851 CQRENQELNAHNQELNN 867
++E +++ + +++ N
Sbjct: 421 LEKEREKILEYKRQVQN 437
Score = 34.3 bits (77), Expect = 0.62
Identities = 24/85 (28%), Positives = 39/85 (45%), Gaps = 5/85 (5%)
Query: 737 KKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQIS 796
+KIE + + +RE LR E +RL AE I IE E+ RE + ++ S
Sbjct: 1879 RKIESEREKSEREKNSLRSEIERLQAE-----IKRIEERCRRKLEDSTRETQSQLETERS 1933
Query: 797 SVNSDVEALRRQYLEELQSVQRELE 821
+++ LR++ + Q E E
Sbjct: 1934 RYQREIDKLRQRPYGSHRETQTECE 1958
Score = 32.7 bits (73), Expect = 1.8
Identities = 58/282 (20%), Positives = 114/282 (40%), Gaps = 21/282 (7%)
Query: 743 QRQHQRELEKLREEKDRLLAE---ETAATISAIEAMKNAHREEMERELEKSQRSQISSVN 799
+R E++K+ E + + + A+ S +E + N ++R + +S I
Sbjct: 940 KRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNI---PIKRTMIQSPSGVILQEA 996
Query: 800 SDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELN 859
+DV A + L R L + + L+N + + LE E + R EN N
Sbjct: 997 ADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKI-EVLEEELRLARDANSENCNKN 1055
Query: 860 AHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQE 919
+ + AE ++ + L E GK A + L +I+ L ++
Sbjct: 1056 KFLDQNLQKYQAECSQFKAKLASLE--ELKRQAELDGKSAKQN---LDKCYGQIKELNEK 1110
Query: 920 ISSLKDELQTALRDKKYASDKY---KDIYTELSIAKAKADCDISRLKEQLKAATEALGEK 976
I+ L E++ R +K D++ K+ Y +L A+ C+ L Q + +A+ EK
Sbjct: 1111 ITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEK 1167
Query: 977 SPD---SATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSK 1015
+ + + + + + L K R+ ++ N+R+K
Sbjct: 1168 EYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNK 1209
Score = 32.7 bits (73), Expect = 1.8
Identities = 27/85 (31%), Positives = 43/85 (50%), Gaps = 4/85 (4%)
Query: 679 LEKELEQSQKEASDLLEQNRLLQDQLR-VALGREQSAREGYVLQATCERGFAAM---EET 734
LE E +Q Q + + Q ++ +R + RE+S RE L++ ER A + EE
Sbjct: 1853 LECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEER 1912
Query: 735 HQKKIEDLQRQHQRELEKLREEKDR 759
++K+ED R+ Q +LE R R
Sbjct: 1913 CRRKLEDSTRETQSQLETERSRYQR 1937
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 68.9 bits (167), Expect = 2e-11
Identities = 100/434 (23%), Positives = 187/434 (43%), Gaps = 32/434 (7%)
Query: 510 RPTEKQEAELGE-PDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADT 568
R E+Q+ E P+ E+K R R+RR + F E + ++ AQ+
Sbjct: 799 RAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE 858
Query: 569 HEPLRPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLK 628
+ R E ++ R + EER++R L A AL+ ++ + L + + +
Sbjct: 859 DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP-------ALQEQLRKEQQL-LQEEE 910
Query: 629 THNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRL-STHELTSLLEKELEQSQ 687
E E+R Q + REE+Q+ L E+ R E +K+L+Q +
Sbjct: 911 EELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKE 970
Query: 688 KEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQ 747
++ + R Q+ RE+ RE LQ E+ EE +++ ++ +RQ++
Sbjct: 971 EQLLGEEPEKRRRQE-------REKKYREEEELQQEEEQ--LLREEREKRRRQEWERQYR 1021
Query: 748 RELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRR 807
++ ++L++E+++LL EE E + RE RE E+ Q+ + + + E RR
Sbjct: 1022 KK-DELQQEEEQLLREER-------EKRRLQERERQYREEEELQQEEEQLLGEERETRRR 1073
Query: 808 QYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNN 867
Q EL+ R+ E L ++ Q E + E ERQ + + + +E +E
Sbjct: 1074 Q---ELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREK 1130
Query: 868 RLAAEITR-LRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDE 926
R E+ R R E + + ELE R +E E+Q ++++ + E
Sbjct: 1131 RRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYR-EEEELQQEEEQLLREEQE 1189
Query: 927 LQTALRDKKYASDK 940
+ R+++Y ++
Sbjct: 1190 KRRQERERQYREEE 1203
Score = 63.2 bits (152), Expect = 1e-09
Identities = 91/405 (22%), Positives = 164/405 (40%), Gaps = 68/405 (16%)
Query: 514 KQEAELGEPDPEQKRSRA-------------RERRREGRSKTFDWAEFRPIQQALAQERV 560
KQE + + E+KR R R+++ E + + F W + ++R+
Sbjct: 725 KQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRL 784
Query: 561 GGVGPADTHEPLRPEAE----------PGELERERARR-REERRKRFGMLDATDGPGTED 609
P + AE P E E+E+ RR R ER K L+ + +
Sbjct: 785 SARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRE 844
Query: 610 AALRMEVDRSPGLPMSDLKTHNVHVEIEQRW------------HQVETTP-----LREEK 652
A +++ + GL + + +Q+W H + P LR+E+
Sbjct: 845 RAQQLQ-EEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQ 903
Query: 653 QVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLL-EQNRLLQDQL--RVALG 709
Q+ L E+ + L E +E E+ +E L E+ +LL+++ R
Sbjct: 904 QL------LQEEE--EELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE 955
Query: 710 REQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATI 769
RE+ R+ LQ E+ EE +++ ++ ++++ RE E+L++E+++LL EE
Sbjct: 956 RERQYRKDKKLQQKEEQLLG--EEPEKRRRQEREKKY-REEEELQQEEEQLLREER---- 1008
Query: 770 SAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQ 829
+ R+E ER+ K Q E ++ L+E + RE E L ++ Q
Sbjct: 1009 ------EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQ 1062
Query: 830 KCLENAHLAQALEAERQALR--QCQRENQELNAHNQELNNRLAAE 872
E + E ERQ + + Q+E ++L E R E
Sbjct: 1063 LLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERE 1107
Score = 61.2 bits (147), Expect = 5e-09
Identities = 83/378 (21%), Positives = 143/378 (37%), Gaps = 43/378 (11%)
Query: 494 LPEEKNKSSCSFETCPRPTE---KQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRP 550
L EE+ + + P E K++ L E + E +R +RRR+ + + ++R
Sbjct: 878 LEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQER-----QYRE 932
Query: 551 IQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLDATDGPGTEDA 610
+Q +E + LR E E +R R R + RK + + E+
Sbjct: 933 EEQLQQEEE----------QLLREERE----KRRRQERERQYRKDKKLQQKEEQLLGEEP 978
Query: 611 ALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRL 670
R +R K + E++Q Q+ LREE++ D L
Sbjct: 979 EKRRRQERE--------KKYREEEELQQEEEQL----LREEREKRRRQEWERQYRKKDEL 1026
Query: 671 STHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAA 730
E L E+ ++ +E + LQ + LG E+ R L+ +
Sbjct: 1027 QQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEEL 1086
Query: 731 MEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKS 790
+E Q E+ +++ ++E E+ E++ L EE E + E RE E+
Sbjct: 1087 QQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEV 1146
Query: 791 QRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQ 850
Q+ + + + E RRQ LE + EL+ EQ L + E RQ +
Sbjct: 1147 QQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQL---------LREEQEKRRQERER 1197
Query: 851 CQRENQELNAHNQELNNR 868
RE +EL ++ R
Sbjct: 1198 QYREEEELQRQKRKQRYR 1215
Score = 60.5 bits (145), Expect = 8e-09
Identities = 96/452 (21%), Positives = 175/452 (38%), Gaps = 51/452 (11%)
Query: 510 RPTEKQEAELGEPDPEQKRSRAR----------ERRREGRSKTFDWAEFRPIQQALAQER 559
R E+QE + EQ++ R R E RRE + + + E R Q+ +++
Sbjct: 279 RKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQ 338
Query: 560 VGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRS 619
+ + LR E E E++ R +EE R+ + + ++ R
Sbjct: 339 LRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRRE 398
Query: 620 PGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLL 679
L + EQ+ LR E+Q L E +R
Sbjct: 399 QQLRREQQLRREQQLRREQQ--------LRREQQ-------LRREQEEERHEQKHEQERR 443
Query: 680 EKELEQSQKEASDLL----EQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETH 735
E+ L++ Q+E D L E R Q++ + L R+Q ER EE
Sbjct: 444 EQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERR-------ERWLKLEEEER 496
Query: 736 QKKIEDLQRQHQRELEKLREEKDRLLAEETAAT--ISAIEAMKNAHREEMERELEKSQRS 793
+++ E ++Q +RE E+ RE++ + EE + + + ++ E E+ L++ +
Sbjct: 497 REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEK 556
Query: 794 QISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAER-QALRQCQ 852
++ + R Q Q ++RE E ++ ++ + L Q L+ E + L Q +
Sbjct: 557 RLEQERREQRLKREQEERRDQLLKREEERRQQRLKRE--QEERLEQRLKREEVERLEQEE 614
Query: 853 RENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESE 912
R Q L E R + LL + E L + + + L R +E E
Sbjct: 615 RREQRLKREEPEEERR--------QQLLKSEEQEERRQQQLRREQQERREQRLKREEEEE 666
Query: 913 --IQYLKQEISSLKDELQTALRDKKYASDKYK 942
Q LK+E + E + A +++ A ++ K
Sbjct: 667 RLEQRLKREHEEERREQELAEEEQEQARERIK 698
Score = 58.5 bits (140), Expect = 3e-08
Identities = 87/380 (22%), Positives = 154/380 (40%), Gaps = 49/380 (12%)
Query: 496 EEKNKSSCSFETCPRPTEKQEAELGEPDP------EQKRSRARERRREGRSKTFDWAEFR 549
+E+ ++ C + +QE + +P E+ R R++R+E + + E
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEE-- 153
Query: 550 PIQQALAQERVGGVGPADTHEPLRPEAEPGELERERA--RRREERRKRFGMLDATDGPGT 607
Q+ QER+ E + EL R+R + REERR L + G T
Sbjct: 154 ---QSEKQERL---------EQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHET 201
Query: 608 EDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGG 667
E+ ++ R L + + + ++R Q EEK+ L E+
Sbjct: 202 EEFPDEEQLRRRELLELR--RKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK 259
Query: 668 DRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERG 727
+ + L++E EQ +K L + R ++Q + L REQ R
Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRR----------- 308
Query: 728 FAAMEETHQKKIEDLQRQHQR--ELEKLREEKDRLLAEETAATISAIEAMKNAHREEMER 785
EE +++ E+ + Q +R + E+ RE++ R EE E + +++ R
Sbjct: 309 --KQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRR 366
Query: 786 ELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAER 845
E E+ +R Q + + + R Q L Q ++RE ++ EQ ++ Q L E+
Sbjct: 367 EQEEERREQ--QLRREQQLRREQQLRREQQLRREQQLRREQQLRR-------EQQLRREQ 417
Query: 846 QALRQCQ-RENQELNAHNQE 864
Q R+ Q R QE H Q+
Sbjct: 418 QLRREQQLRREQEEERHEQK 437
Score = 58.2 bits (139), Expect = 4e-08
Identities = 94/446 (21%), Positives = 175/446 (39%), Gaps = 73/446 (16%)
Query: 513 EKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPL 572
+++E +L +PE++R + ER+ + E +QQ + + L
Sbjct: 1147 QQEEEQLLREEPEKRRRQELERQ---------YREEEELQQ-------------EEEQLL 1184
Query: 573 RPEAEPGELERERARRREE---RRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKT 629
R E E ERER R EE R+KR D + + L+ + + + D K
Sbjct: 1185 REEQEKRRQERERQYREEEELQRQKRKQRYRDED----QRSDLKWQWEPEKENAVRDNKV 1240
Query: 630 HNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTH-----------ELTSL 678
+ E EQ + Q+E + LR+ + L + DR E L
Sbjct: 1241 YCKGRENEQ-FRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQL 1299
Query: 679 LEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAR----EGYVLQATCERGFAAMEET 734
+E +++++ E+ +LL+++ R+++ R E +LQ E+ E
Sbjct: 1300 EREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERD 1359
Query: 735 HQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQ 794
+ + E+L+ HQ + K EE+ RL +E E E + ++ ++ +
Sbjct: 1360 RKFREEELR--HQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFR 1417
Query: 795 ISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRE 854
+ R++ EE Q V+R+ E+ + E L Q + + Q +E
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRRQ-----ERERKFLEEEQQLRQERHRKFREEEQLLQE 1472
Query: 855 NQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQ 914
+E H QE + + E +LR Q +D E LR +E E +
Sbjct: 1473 REEQQLHRQERDRKFLEEEQQLR----------------RQERDRKFREQELRSQEPERK 1516
Query: 915 YLKQEISSLKDELQTALRDKKYASDK 940
+L++E +L R +K+ ++
Sbjct: 1517 FLEEE-----QQLHRQQRQRKFLQEE 1537
Score = 55.8 bits (133), Expect = 2e-07
Identities = 70/303 (23%), Positives = 127/303 (41%), Gaps = 42/303 (13%)
Query: 587 RRREERRKRFGMLDAT--DGPGTEDAALRMEVDR--SPGLPMSD----LKTHNVHVEIEQ 638
RR+EE ++RF D + PG R E +R + G S+ L+ + E+
Sbjct: 113 RRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEE 172
Query: 639 RWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNR 698
W Q + REE++ + E+ HE ++E Q +LLE R
Sbjct: 173 LWRQRQEWQEREERR--------AEEEQLQSCKGHETEEFPDEE----QLRRRELLELRR 220
Query: 699 LLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKD 758
GRE+ ++ Q +R F EE +K E + R+ + +L++ ++
Sbjct: 221 K---------GREEKQQQRRERQ---DRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ 268
Query: 759 RLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLE--ELQSV 816
R L EE E ++ R+E+ RE ++ ++ Q + + + R+Q E E Q
Sbjct: 269 RELQEEE-------EQLRKLERQELRRERQEEEQQQ-QRLRREQQLRRKQEEERREQQEE 320
Query: 817 QRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRL 876
+RE + EQ ++ + Q E+Q R+ + E +E ++ R ++ R
Sbjct: 321 RREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRRE 380
Query: 877 RTL 879
+ L
Sbjct: 381 QQL 383
Score = 51.6 bits (122), Expect = 4e-06
Identities = 109/465 (23%), Positives = 180/465 (38%), Gaps = 49/465 (10%)
Query: 513 EKQEAELGEPDPEQKRSRARERR--------REGRSKTFDWAEFRPIQQALAQERVGGVG 564
+K+E LGE +PE++R + RE++ +E + E R Q+ Q R
Sbjct: 968 QKEEQLLGE-EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDEL 1026
Query: 565 PADTHEPLRPEAEPGEL-ERERARRREERRKRFGMLDATDGPGTE-DAALRMEVDRS--P 620
+ + LR E E L ERER R EE ++ + G E + R E++R
Sbjct: 1027 QQEEEQLLREEREKRRLQERERQYREEEELQQ----EEEQLLGEERETRRRQELERQYRK 1082
Query: 621 GLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLE 680
+ + + E E+R Q REE+++ L E+ R EL
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKR-RRQELERQYR 1141
Query: 681 KELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIE 740
+E E Q+E L E+ + Q RE+ + Q E +E ++ E
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYRE 1201
Query: 741 DLQRQHQRELEKLREEKDR-----LLAEETAATISAIEAMKNAHREEMERELEKSQRSQI 795
+ + Q Q+ ++ R+E R E + + E R+LE SQ
Sbjct: 1202 EEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDR 1261
Query: 796 SSVNS-----------DVEALRRQYLE------ELQSVQRELEVLSEQYSQKCLENAHLA 838
S D E RR++ + E + ++RE + +++ +K E
Sbjct: 1262 QSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEE---K 1318
Query: 839 QALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKD 898
Q L ER+ R+ Q +++ Q L R E LR E QG+
Sbjct: 1319 QLLREEREEKRRRQETDRKFREEEQLLQER---EEQPLRRQERDRKFREEELRHQEQGRK 1375
Query: 899 AYELEVLLRVKESEIQYLKQEISSLKDELQTAL---RDKKYASDK 940
E E LR +E E ++LK+E E + L RD+K+ ++
Sbjct: 1376 FLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEE 1420
Score = 50.8 bits (120), Expect = 6e-06
Identities = 87/385 (22%), Positives = 146/385 (37%), Gaps = 39/385 (10%)
Query: 496 EEKNKSSCSFETCPRPTEKQ--------EAELGEPDPEQKRSRARERRREGRSKTFDWAE 547
EE+ K ET R E++ + EL E + + ++ +E RRE + +
Sbjct: 240 EEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQR 299
Query: 548 FRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLDATDGPGT 607
R QQ ++ + + E E RE+ RRE+ +R L
Sbjct: 300 LRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEER 359
Query: 608 EDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGG 667
+ LR E + + + + E + R Q LR E+Q+ L E
Sbjct: 360 REQQLRREQEE-------ERREQQLRREQQLRREQ----QLRREQQLR-REQQLRREQQL 407
Query: 668 DRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERG 727
R L +E +Q ++E + + + Q++ L REQ R ++ +
Sbjct: 408 RREQQLRREQQLRRE-QQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKRE----- 461
Query: 728 FAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMEREL 787
EET + + E ++Q +R+ E+ R E+ L EE E + R E E
Sbjct: 462 ----EETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQ--ERREQQLRREQEERR 515
Query: 788 EKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQA 847
E+ + Q + E +Q L Q ++RE E EQ ++ E L Q +R
Sbjct: 516 EQRLKRQ------EEEERLQQRLRSEQQLRREQEERREQLLKR-EEEKRLEQERREQRLK 568
Query: 848 LRQCQRENQELNAHNQELNNRLAAE 872
Q +R +Q L + RL E
Sbjct: 569 REQEERRDQLLKREEERRQQRLKRE 593
Score = 48.9 bits (115), Expect = 2e-05
Identities = 89/460 (19%), Positives = 176/460 (38%), Gaps = 64/460 (13%)
Query: 496 EEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQAL 555
EE+ + E R +++ + + + E++R + +R E R + + ++Q L
Sbjct: 543 EERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRL 602
Query: 556 AQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRME 615
+E V + + E EP E R++ + EE+ +R + R +
Sbjct: 603 KREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER-----------RQQQLRREQ 651
Query: 616 VDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHEL 675
+R LK +EQR + RE++
Sbjct: 652 QERRE----QRLKREEEEERLEQRLKREHEEERREQE----------------------- 684
Query: 676 TSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETH 735
L E+E EQ+++ + + Q QL QS + +R EE
Sbjct: 685 --LAEEEQEQARERIKSRIPK---WQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKR 739
Query: 736 QKKIEDLQRQHQRELEKLREEKD-------RLLAEETAATISAIEAMKNAHREEMERELE 788
+++ +LQ Q + + ++E++ + AEE + + + RE+ ER+L
Sbjct: 740 RRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLR 799
Query: 789 KSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQAL 848
+R Q E + Q + + ++EL+ L E ++ L+ AQ L+ E L
Sbjct: 800 AEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEE---EEQLQRRERAQQLQEEEDGL 856
Query: 849 RQCQ-RENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLR 907
++ Q R + +Q+ +L E R R L P Q + E + LL+
Sbjct: 857 QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTL--------YAKPALQEQLRKE-QQLLQ 907
Query: 908 VKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTE 947
+E E+Q ++E + E + R+++ + + + E
Sbjct: 908 EEEEELQREERE-KRRRQEQERQYREEEQLQQEEEQLLRE 946
Score = 42.0 bits (97), Expect = 0.003
Identities = 76/368 (20%), Positives = 140/368 (38%), Gaps = 64/368 (17%)
Query: 513 EKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPL 572
++QE + E + + +R +++ R+ R + +FR +Q L QER + +
Sbjct: 1591 QEQERKFMEDEQQLRRQEGQQQLRQERDR-----KFREDEQLL-QER-------EEQQLH 1637
Query: 573 RPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNV 632
R E + LE E RR+ER ++ LR + DR
Sbjct: 1638 RQERDRKFLEEEPQLRRQEREQQ----------------LRHDRDRK------------- 1668
Query: 633 HVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKE-----LEQSQ 687
E EQ + E LR +++ DR E L +E L++ Q
Sbjct: 1669 FREEEQLLQEGEEQQLRRQER--------------DRKFREEEQQLRRQERERKFLQEEQ 1714
Query: 688 KEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQ 747
+ LE+ ++QLR +EQ R+ + E E Q + ++ R+
Sbjct: 1715 QLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKF- 1773
Query: 748 RELEKLREEKD--RLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEAL 805
RE E+LR+E++ +L ++E+ E ++ E+ R ++ + + +E
Sbjct: 1774 REEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQ 1833
Query: 806 RRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQEL 865
++ +E R E + Q + E + + RQ + RE +E
Sbjct: 1834 EQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQ 1893
Query: 866 NNRLAAEI 873
+R EI
Sbjct: 1894 RHRQVGEI 1901
>gi|58535453 CDK5 regulatory subunit associated protein 2 isoform b
[Homo sapiens]
Length = 1814
Score = 68.2 bits (165), Expect = 4e-11
Identities = 70/327 (21%), Positives = 142/327 (43%), Gaps = 33/327 (10%)
Query: 678 LLEKELEQSQKEASDLL---EQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEET 734
LLEK++ +Q E E + L+ +L L + EG + A + +
Sbjct: 166 LLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEG-------DLAMALVLDE 218
Query: 735 HQKKIEDLQ---RQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQ 791
+ IE+L+ + + ++ L+EEK ++ + + + + A REE ERE E +Q
Sbjct: 219 KDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQ 278
Query: 792 RSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQC 851
NS + E +Q+++ +L + + + + +A++ AL+
Sbjct: 279 MEHQKERNS--------FEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSK 330
Query: 852 QRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLR---- 907
+++ +ELN+ ++L+ A L+ T + G GK+A L LR
Sbjct: 331 EKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEA--LSAALRSQNL 388
Query: 908 VKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLK 967
K +E L++ I + EL ++++ ++ + E K+K DC I L+ +++
Sbjct: 389 TKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHRE----KSKGDCTIRDLRNEVE 444
Query: 968 AATEALGEKSPDSATVSGYDIMKSKSN 994
+ E+ + A + Y + S+SN
Sbjct: 445 KLRNEVNER--EKAMENRYKSLLSESN 469
Score = 47.8 bits (112), Expect = 5e-05
Identities = 74/343 (21%), Positives = 133/343 (38%), Gaps = 61/343 (17%)
Query: 686 SQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIE----- 740
+Q E + +E++ L L + E SA T E+ F + ++ + E
Sbjct: 1328 TQNELMERIEEDNLTYQHL-LPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVM 1386
Query: 741 ------DLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMER--------- 785
DL +H +E+ LR+ EE+ T + E +
Sbjct: 1387 VNSFSQDLLMEHIQEIRTLRKR-----LEESIKTNEKLRKQLERQGSEFVQGSTSIFASG 1441
Query: 786 -ELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAE 844
EL S S+I + +AL ++ + Q+E + L E S+K + HL + +
Sbjct: 1442 SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASV 1501
Query: 845 RQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYEL-E 903
++ + Q+E E HNQ+L + +G L++ ++ +L +
Sbjct: 1502 KEENERLQKEGSEKERHNQQLIQEV-----------------RCSGQELSRVQEEVKLRQ 1544
Query: 904 VLLRVKESEIQYLKQEISSLK--DELQTALRD-KKY--ASDKYKDIYTELSIAKAKADCD 958
LL + +Q L+ E+ + + DE LRD KY SD D++ K+
Sbjct: 1545 QLLSQNDKLLQSLRVELKAYEKLDEEHRRLRDGDKYPMESDNSFDLFDSSQAVTPKS--- 1601
Query: 959 ISRLKEQLKAATEALGEKSPDSAT--------VSGYDIMKSKS 993
+S T++L S SAT V+G+ + SK+
Sbjct: 1602 VSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKN 1644
>gi|58535451 CDK5 regulatory subunit associated protein 2 isoform a
[Homo sapiens]
Length = 1893
Score = 68.2 bits (165), Expect = 4e-11
Identities = 70/327 (21%), Positives = 142/327 (43%), Gaps = 33/327 (10%)
Query: 678 LLEKELEQSQKEASDLL---EQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEET 734
LLEK++ +Q E E + L+ +L L + EG + A + +
Sbjct: 166 LLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKKMHEG-------DLAMALVLDE 218
Query: 735 HQKKIEDLQ---RQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQ 791
+ IE+L+ + + ++ L+EEK ++ + + + + A REE ERE E +Q
Sbjct: 219 KDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQ 278
Query: 792 RSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQC 851
NS + E +Q+++ +L + + + + +A++ AL+
Sbjct: 279 MEHQKERNS--------FEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSK 330
Query: 852 QRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLR---- 907
+++ +ELN+ ++L+ A L+ T + G GK+A L LR
Sbjct: 331 EKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEA--LSAALRSQNL 388
Query: 908 VKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLK 967
K +E L++ I + EL ++++ ++ + E K+K DC I L+ +++
Sbjct: 389 TKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHRE----KSKGDCTIRDLRNEVE 444
Query: 968 AATEALGEKSPDSATVSGYDIMKSKSN 994
+ E+ + A + Y + S+SN
Sbjct: 445 KLRNEVNER--EKAMENRYKSLLSESN 469
Score = 50.1 bits (118), Expect = 1e-05
Identities = 69/328 (21%), Positives = 128/328 (39%), Gaps = 61/328 (18%)
Query: 686 SQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIE----- 740
+Q E + +E++ L L + E SA T E+ F + ++ + E
Sbjct: 1328 TQNELMERIEEDNLTYQHL-LPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVM 1386
Query: 741 ------DLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMER--------- 785
DL +H +E+ LR+ EE+ T + E +
Sbjct: 1387 VNSFSQDLLMEHIQEIRTLRKR-----LEESIKTNEKLRKQLERQGSEFVQGSTSIFASG 1441
Query: 786 -ELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAE 844
EL S S+I + +AL ++ + Q+E + L E S+K + HL + +
Sbjct: 1442 SELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASV 1501
Query: 845 RQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYEL-E 903
++ + Q+E E HNQ+L + +G L++ ++ +L +
Sbjct: 1502 KEENERLQKEGSEKERHNQQLIQEV-----------------RCSGQELSRVQEEVKLRQ 1544
Query: 904 VLLRVKESEIQYLKQEISSLK--DELQTALRDKK----YASDKYKDIYT---ELSIAKAK 954
LL + +Q L+ E+ + + DE LR+ D ++D+++ E+ + +
Sbjct: 1545 QLLSQNDKLLQSLRVELKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQ 1604
Query: 955 ADCDI-------SRLKEQLKAATEALGE 975
+ I SRLKEQL E E
Sbjct: 1605 LERSIETSSTLQSRLKEQLARGAEKAQE 1632
Score = 34.7 bits (78), Expect = 0.47
Identities = 68/325 (20%), Positives = 118/325 (36%), Gaps = 51/325 (15%)
Query: 675 LTSLLEKELEQSQKEASDLL--EQNRLLQDQLRVALGREQSAREGY----VLQATCERGF 728
L L E+ Q + DL + L+Q Q R + Q ++G+ + +
Sbjct: 1219 LNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMI 1278
Query: 729 AAMEETHQKKIED--LQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERE 786
A EE Q D + Q +L + E ++L E+ ++ N E MER
Sbjct: 1279 KAFEELLQASDVDYCVAEGFQEQLNQCAELLEKL--EKLFLNGKSVGVEMNTQNELMERI 1336
Query: 787 ----------LEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAH 836
L +S S SD E + + Q E E S + N+
Sbjct: 1337 EEDNLTYQHLLPESPEPSASHALSDYETSEKSFFSRDQKQDNETEKTS------VMVNSF 1390
Query: 837 LAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQG 896
L Q +R ++ +E N++L +L E GS QG
Sbjct: 1391 SQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQL-----------------ERQGSEFVQG 1433
Query: 897 KDAY-----ELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIA 951
+ EL L SEI +L+++ +L L RDK+ +DK ++ + +++
Sbjct: 1434 STSIFASGSELHSSLT---SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVS 1490
Query: 952 KAKADCDISRLKEQLKAATEALGEK 976
+ + +KE+ + + EK
Sbjct: 1491 LEHLQREYASVKEENERLQKEGSEK 1515
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 68.2 bits (165), Expect = 4e-11
Identities = 93/401 (23%), Positives = 166/401 (41%), Gaps = 60/401 (14%)
Query: 672 THELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAM 731
T ELT+L ++Q +E + L +Q + Q QL L +++ A +G L+ E+ +++
Sbjct: 504 TSELTTL-NATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQG--LRHQVEQLSSSL 560
Query: 732 EETHQK------KIEDLQRQHQRELEKLREEKDRLLAEETAAT--ISAIEAMKNAHREEM 783
++ Q+ K E ++ H ++L EE++ L E AA + A+E K A E +
Sbjct: 561 KQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEIL 620
Query: 784 ERELEKSQRSQISSVNSDVEALR-------------------RQYLEELQSVQRELEVLS 824
+++L+ + ++ S+ S +A R RQ E Q+ ELE+
Sbjct: 621 QQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQL 680
Query: 825 EQYSQKCLENAHLAQ---------------------ALEAERQ----ALRQCQRENQELN 859
QK E +AQ +LE E++ AL + QR EL
Sbjct: 681 RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK 740
Query: 860 AHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQE 919
A + L + E L G G EA L + A E EVL R E+
Sbjct: 741 AETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQA-ETEVLRR----ELAEAMAA 795
Query: 920 ISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEALGEKSPD 979
+ + E + +++ ++Y+D E + A + LKE+ + A + L E
Sbjct: 796 QHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEK 855
Query: 980 SATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSVIEQ 1020
A + + ++ + L + + + R L+ ++ K V Q
Sbjct: 856 VAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQ 896
Score = 58.2 bits (139), Expect = 4e-08
Identities = 106/489 (21%), Positives = 193/489 (39%), Gaps = 89/489 (18%)
Query: 572 LRPEAEPGELER------ERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMS 625
L E E EL+R E++++ EER + +L A + AA R R
Sbjct: 1242 LEKEGESKELKRLVMAESEKSQKLEERLR---LLQAETASNSARAAERSSALRE------ 1292
Query: 626 DLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLST--------HELTS 677
+ ++ E E++ +V + LR+E + +E+ G L + S
Sbjct: 1293 --EVQSLREEAEKQ--RVASENLRQE----LTSQAERAEELGQELKAWQEKFFQKEQALS 1344
Query: 678 LLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQK 737
L+ E +Q S+LL L Q E+ RE G A Q+
Sbjct: 1345 TLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQR 1404
Query: 738 KIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAH-----------------R 780
++ +L Q+ E+ R + L E A+ + +K AH R
Sbjct: 1405 ELGELIPLRQKVAEQERTAQQ--LRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGR 1462
Query: 781 EEMERELEKSQRS---QISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHL 837
+ +E EL++++ ++++V +D E + E QS RELEV++ +Y ++
Sbjct: 1463 QFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEE 1522
Query: 838 AQALEAERQAL----RQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPL 893
Q + ERQ L Q + +E +EL+ +LA S
Sbjct: 1523 RQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLA-------------------DSDQ 1563
Query: 894 AQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKA 953
A +L+ ++ + E Q Q + + +ELQ L K+ A++ YK L + KA
Sbjct: 1564 ASKVQQQKLKA-VQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYK-----LQMEKA 1617
Query: 954 KADCDISR-----LKEQLKAATEALGEKSPDSATVS--GYDIMKSKSNPDFLKKDRSCVT 1006
K D + L+EQL++ + E A G+++ ++ ++ +T
Sbjct: 1618 KTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLT 1677
Query: 1007 RQLRNIRSK 1015
Q+R++ ++
Sbjct: 1678 AQVRSLEAQ 1686
Score = 53.9 bits (128), Expect = 8e-07
Identities = 100/461 (21%), Positives = 198/461 (42%), Gaps = 56/461 (12%)
Query: 552 QQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAA 611
Q A+ Q+R+ + + + P EP ELE R + + L TE
Sbjct: 250 QIAMMQQRIDRLALLNEKQAASP-LEPKELEELRDKNESLTMRLHETLKQCQDLKTE--- 305
Query: 612 LRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLS 671
+ ++DR ++ L N + + R L++ A L+ E
Sbjct: 306 -KSQMDRK----INQLSEENGDLSFKLREFASHLQQLQD------ALNELTEEHSKATQE 354
Query: 672 THELTSLLEKELEQSQKEASDLLEQNRLLQ----------DQLRVALGREQSAREGYVLQ 721
E + LEKEL + ++ L E+N +LQ QL+ +E+ G VLQ
Sbjct: 355 WLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQ 414
Query: 722 ATCER----GFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKN 777
+ AA Q ++E L+ + ++ KL E+ EE S I +++
Sbjct: 415 LETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGH-FEEEKQQLSSLITDLQS 473
Query: 778 --AHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENA 835
++ + + ELE++ ++ + + + V +L + ++Q++ + L+ Q + A
Sbjct: 474 SISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQA 533
Query: 836 HLAQALEAERQALRQCQRENQELNAHNQELNNRL-----AAEITR---LRTLLTGDGGGE 887
LAQ L+ + QA + + + ++L++ ++ +L E TR + L T E
Sbjct: 534 QLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEERE 593
Query: 888 ATGSPLAQGKDA--YELEVLLRVKESEIQYLKQEI---SSLKDELQT----ALRDKKYAS 938
A+ + +DA +LE L + K ++++ L+Q++ + +D QT A R+K S
Sbjct: 594 AS----LRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELS 649
Query: 939 DKYKDIYTELSIAKA---KADCDISRLKEQLKAATEALGEK 976
K +++ + A+ +A ++ L+ QL++ + EK
Sbjct: 650 RKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEK 690
Score = 53.5 bits (127), Expect = 1e-06
Identities = 64/304 (21%), Positives = 133/304 (43%), Gaps = 34/304 (11%)
Query: 692 DLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETH----QKKIEDLQRQHQ 747
D+L+ + +L+ L E+S R+ L+ R ++ Q++I+ L ++
Sbjct: 207 DILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNE 266
Query: 748 R---------ELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSV 798
+ ELE+LR++ + L T+ E +K + E+ + +Q+S
Sbjct: 267 KQAASPLEPKELEELRDKNESL-------TMRLHETLKQCQDLKTEKSQMDRKINQLSEE 319
Query: 799 NSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQEL 858
N D+ R++ LQ +Q L L+E++S+ E LE E A Q ++ +E
Sbjct: 320 NGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEK 379
Query: 859 NAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVL------LRVKESE 912
N Q ++L +++L+ D + G L D +LE L L ++
Sbjct: 380 NEILQGKLSQLEEHLSQLQ-----DNPPQEKGEVLG---DVLQLETLKQEAATLAANNTQ 431
Query: 913 IQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEA 972
+Q + + + + + + L ++ ++ K + L + ++S+ KE+L+ A++A
Sbjct: 432 LQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQA 491
Query: 973 LGEK 976
G +
Sbjct: 492 HGAR 495
Score = 46.2 bits (108), Expect = 2e-04
Identities = 109/569 (19%), Positives = 220/569 (38%), Gaps = 118/569 (20%)
Query: 493 SLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRAR-ERRREGRSKT--------- 542
SL EEK +++ + E R + +AE + KR R E R GR
Sbjct: 717 SLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGE 776
Query: 543 FDWAEFRPIQQALAQERVGGVGPADTHEPL---------------RPEAEPGELERERAR 587
AE +++ LA+ E L + EA+ G + +E+
Sbjct: 777 AHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLM 836
Query: 588 RREER--RKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVET 645
+E + R + +A + ++ +++ R + +H + + QV+
Sbjct: 837 TLKEECEKARQELQEAKEKVAGIESHSELQISRQQN------ELAELHANLARALQQVQE 890
Query: 646 TPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLR 705
+R +K L + L +L+ K EQ + + +L+++ D+
Sbjct: 891 KEVRAQKLADDLST-LQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQP 949
Query: 706 VALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQR--------QHQRELEKLREEK 757
L EQ R+ QA + AME ++ +L+R Q Q++ E+ ++E+
Sbjct: 950 EWL-EEQQGRQFCSTQAALQ----AMEREAEQMGNELERLRAALMESQGQQQEERGQQER 1004
Query: 758 DRLLAEETAATISAIEAMKNAHREEMERELEKS---QRSQISSVN--------------- 799
+ + A A++ A R E+E L+ + QR + +++
Sbjct: 1005 EVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQ 1064
Query: 800 --SDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAH-----------------LAQA 840
+ + L ++EL+ +++ ++ L EQ ++K E+A +A
Sbjct: 1065 ELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEA 1124
Query: 841 LEAERQAL-RQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDA 899
L AE L +QCQ++ ++ ++ + L A+ R L T
Sbjct: 1125 LRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALET------------------ 1166
Query: 900 YELEVLLRVKESEIQYLKQEISSLKDEL---QTALRDKKYASDKYKDIYTELSIAKAKAD 956
L+ L K E+ + + ++S + EL +T ++D A D++K +A+ + +
Sbjct: 1167 --LQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWK-----AQVARGRQE 1219
Query: 957 CD-----ISRLKEQLKAATEALGEKSPDS 980
+ IS L+E++ + EK +S
Sbjct: 1220 AERKNSLISSLEEEVSILNRQVLEKEGES 1248
>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
Length = 1140
Score = 68.2 bits (165), Expect = 4e-11
Identities = 79/318 (24%), Positives = 137/318 (43%), Gaps = 79/318 (24%)
Query: 627 LKTHNVHVEIEQRWHQ---VETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKEL 683
LK + ++E +W + E + LREE ++ ED +S +L L ++E
Sbjct: 628 LKVDKMAHDLEIKWTENLRQECSKLREELRLQ------HEEDKKSAMS--QLLQLKDREK 679
Query: 684 EQS----QKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERG-----FAAMEET 734
+ QK+ DLL Q LL+ L + L + Q++ + Q T ER +EE
Sbjct: 680 NAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQ 739
Query: 735 HQKKIEDLQRQHQRELEKLREEKD---RLLAEETAATISA-IEAMKNAHREEMER----- 785
HQ++ + L+ H + + EEK+ R L SA ++++K+AHRE ME
Sbjct: 740 HQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEM 799
Query: 786 ---------ELEKSQRSQISSVNSD--------VEALRRQYLEELQSVQRELEV---LSE 825
ELE ++ ++S+ S+ ++ LR + +EL + + ELE +S
Sbjct: 800 EQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISR 859
Query: 826 QYSQKCL----------------------ENAHLAQALEA--------ERQALRQCQREN 855
+ S++ + E HL + + A ++ LR N
Sbjct: 860 RQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKEILRIRSESN 919
Query: 856 QELNAHNQELNNRLAAEI 873
Q++ H Q+LN RL E+
Sbjct: 920 QQIRLHEQDLNKRLEKEL 937
Score = 56.2 bits (134), Expect = 2e-07
Identities = 78/352 (22%), Positives = 150/352 (42%), Gaps = 52/352 (14%)
Query: 671 STHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAA 730
S L + L+ E+ Q E + + +D L G + R+ + E AA
Sbjct: 568 SAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQH------EETIAA 621
Query: 731 MEETHQKKIEDLQRQHQ--------RELEKLREEKDRLLAEETAATISAI----EAMKNA 778
M+E + K++ + + +E KLREE E+ + +S + + KNA
Sbjct: 622 MKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNA 681
Query: 779 HREEMERELE----------KSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYS 828
R+ ++++E ++ Q+S + ++ L+ Q+ +E Q + +ELE L EQ+
Sbjct: 682 ARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQ 741
Query: 829 Q--KCLENAHLA--QALEAERQALRQC------QRENQEL----NAHNQELNN---RLAA 871
Q K L+ AH+ Q +E E++ ++ Q+ + EL +AH + + +
Sbjct: 742 QRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQ 801
Query: 872 EITRLRTLLTGDGGGE-ATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTA 930
E+ LR L +G A+ + A +++L E+ K E L+ + +
Sbjct: 802 ELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKME---LERSIDIS 858
Query: 931 LRDKKYASDKYKDIYTELSIAK---AKADCDISRLKEQLKAATEALGEKSPD 979
R K + D+ EL + ++ D ++ L E + A T+ L K +
Sbjct: 859 RRQSKEHICRITDLQEELRHREHHISELDKEVQHLHENISALTKELEFKGKE 910
Score = 54.3 bits (129), Expect = 6e-07
Identities = 60/303 (19%), Positives = 137/303 (45%), Gaps = 15/303 (4%)
Query: 678 LLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQK 737
+L+K+L+ +++ LL +++ ++ +L A R Q VL+A+ A + T +
Sbjct: 339 VLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEV 398
Query: 738 KIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHRE---EMERELEKSQRSQ 794
I+DL+ + R E+L + L EE A S +++ ++ E+E+++ +++R+Q
Sbjct: 399 TIKDLESEKSRVNERLSQ-----LEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQ 453
Query: 795 ISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQK---CLENAHLAQALEAERQALRQC 851
+++ L+ + EE+ + E+ + K +E H + A+ +++
Sbjct: 454 QEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVH-SNAIRDKKKLQMDL 512
Query: 852 QRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKD-AYELEVLLRVKE 910
+ ++ + + +E N+L E+ L+ +L + + +D + E L E
Sbjct: 513 EEQHNKDKLNLEEDKNQLQQELENLKEVL--EDKLNTANQEIGHLQDMVRKSEQGLGSAE 570
Query: 911 SEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAAT 970
I L+ L++EL K D ++ EL + + + I+ +KE+ K
Sbjct: 571 GLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKV 630
Query: 971 EAL 973
+ +
Sbjct: 631 DKM 633
Score = 47.0 bits (110), Expect = 9e-05
Identities = 56/266 (21%), Positives = 121/266 (45%), Gaps = 41/266 (15%)
Query: 732 EETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQ 791
E+ + +EDLQ H+RE+++L + + + +A+ E + HR E+E
Sbjct: 180 EKDKRLALEDLQAAHRREIQELLKSQQ----DHSASVNKGQEKAEELHRMEVE------- 228
Query: 792 RSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQK--CLENAHL--AQALEAERQA 847
S+N +E LR + + ++ + +L Y ++ L+ + L A++L+A ++
Sbjct: 229 -----SLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEK 283
Query: 848 LRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLR 907
++E Q A ++ +L E+ ++ + GS L + +L+ L
Sbjct: 284 EADLRKEFQGQEAILRKTIGKLKTELQMVQ---------DEAGSLLDK---CQKLQTALA 331
Query: 908 VKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLK 967
+ E+ +Q L++++ K+ L K+K++ +EL+ A+ + S L LK
Sbjct: 332 IAENNVQVLQKQLDDAKEGEMALL-------SKHKEVESELAAARERLQQQASDL--VLK 382
Query: 968 AATEALGEKSPDSATVSGYDIMKSKS 993
A+ + + + + V+ D+ KS
Sbjct: 383 ASHIGMLQATQMTQEVTIKDLESEKS 408
Score = 34.3 bits (77), Expect = 0.62
Identities = 52/256 (20%), Positives = 106/256 (41%), Gaps = 56/256 (21%)
Query: 770 SAIEAMKNAHREEMERELEKSQ----------------RSQISSVNSDVE---ALRRQYL 810
SAI+A+K+AH EE+++ L +++ R +I + S +E +++Q L
Sbjct: 67 SAIQALKDAHEEEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQAL 126
Query: 811 EELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQ-----EL 865
E ++ + +E + Q C E H+ + + R+ ++ ++L + Q E
Sbjct: 127 TEFEAYKHRVEDM-----QLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEK 181
Query: 866 NNRLAAEITR------LRTLLTGDGGGEAT---GSPLAQGKDAYELEVL------LRVKE 910
+ RLA E + ++ LL A+ G A+ E+E L LR++
Sbjct: 182 DKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLER 241
Query: 911 SEI------------QYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCD 958
++ + ++E+ +LK + + +K D+ E +A
Sbjct: 242 KKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKT 301
Query: 959 ISRLKEQLKAATEALG 974
I +LK +L+ + G
Sbjct: 302 IGKLKTELQMVQDEAG 317
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 66.6 bits (161), Expect = 1e-10
Identities = 93/399 (23%), Positives = 172/399 (43%), Gaps = 68/399 (17%)
Query: 673 HELTSLLEKELE-------QSQKEASDLLEQNRLLQDQLRVALGR--EQSAREGYVLQAT 723
+E S L+K +E QSQ+EA+ E+ + ++ L + E S + L+A
Sbjct: 923 NENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR 982
Query: 724 CERGFAAMEETHQKKIEDLQRQHQ-----------------RELEKLREEKDRLLAEETA 766
ER + + H++ +++LQ+ +ELE+LR++ D+ A +TA
Sbjct: 983 YERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTA 1042
Query: 767 ATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQ 826
I + E LE ++++ + + ++++ L+ L+ ++ + + E+L+ +
Sbjct: 1043 EDAMQIMEQMTKEKTETLASLEDTKQTN-AKLQNELDTLKENNLKNVEELNKSKELLTVE 1101
Query: 827 YSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGG 886
+QK E + +E +QA Q ++Q+L+A +E N +LA E+ R R +T
Sbjct: 1102 -NQKMEE---FRKEIETLKQAAAQ---KSQQLSALQEE-NVKLAEELGRSRDEVTSHQKL 1153
Query: 887 EATGSPLAQG------------KDAYE-----------LEVLLRVKESEIQYLKQEISSL 923
E S L KDA E LL K++E++ L+ E+
Sbjct: 1154 EEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEV--- 1210
Query: 924 KDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEALGEKSPDSATV 983
T LR + ++ + L K K + + L+ QLK L S ++ T
Sbjct: 1211 -----TVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQ 1265
Query: 984 SGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSVIEQVS 1022
+ D +S DFL + V Q +N K +E +S
Sbjct: 1266 ADEDERAQESQIDFL--NSVIVDLQRKNQDLKMKVEMMS 1302
Score = 54.3 bits (129), Expect = 6e-07
Identities = 108/459 (23%), Positives = 201/459 (43%), Gaps = 74/459 (16%)
Query: 551 IQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLDAT-DGPGTE- 608
I+Q LA+ + + E + + GE+E+E A R+ + L+A D T
Sbjct: 364 IEQLLAERDL------ERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMV 417
Query: 609 DAALRMEVDRSPGLPMSDLKTHNVHVEIEQRW---HQVETTPLREEKQVPIAPVHLSSED 665
+AA R +V+ L K ++ +E+ +E + E+ ++ L+
Sbjct: 418 EAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLA--- 474
Query: 666 GGDRLSTHELTSLLEKELEQSQKEASD------LLEQNRLLQDQLRVALGREQSAREGYV 719
L E+ L + LE S K A D LL++ LQ++L V R RE
Sbjct: 475 ----LRVQEVAEL-RRRLE-SNKPAGDVDMSLSLLQEISSLQEKLEVT--RTDHQRE--- 523
Query: 720 LQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAH 779
+ + F A EETHQK+I+ L EKL +E + L ++ +++A+
Sbjct: 524 -ITSLKEHFGAREETHQKEIKAL----YTATEKLSKENESLKSK-----------LEHAN 567
Query: 780 REEME-RELEKSQ-RSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHL 837
+E + L KS+ + I+S +E L+ + + L + E L Q + L+ H
Sbjct: 568 KENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHE 627
Query: 838 AQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGK 897
+ L+ +++ E AH +E+ A ++ + + EA S L + +
Sbjct: 628 IENLQ---------NQQDSERAAHAKEME---ALRAKLMKVIKEKENSLEAIRSKLDKAE 675
Query: 898 DAYELEV---LLRVKESEIQYLKQEISSLKDELQTALRDK-----KYASDKYKDIYTELS 949
D + +E+ L +++E+EI+ + E+ K QT + D K +K D+ L
Sbjct: 676 DQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDL-DALR 734
Query: 950 IAKAKADCDISRLKEQLKAATEALG----EKSPDSATVS 984
A ++ ++ +L++QL+AA + + EK+ +S+ S
Sbjct: 735 KASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKAS 773
Score = 34.7 bits (78), Expect = 0.47
Identities = 64/370 (17%), Positives = 142/370 (38%), Gaps = 26/370 (7%)
Query: 650 EEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALG 709
EEK + + + +S +G + L ++LE ++K+ L E + + ++
Sbjct: 724 EEKLLDLDALRKASSEGKSEMKK------LRQQLEAAEKQIKHL-EIEKNAESSKASSIT 776
Query: 710 REQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATI 769
RE RE + + + ++ ++ ++EL+ L+E+ E +
Sbjct: 777 RELQGRELKLTNL----------QENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQR 826
Query: 770 SAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQ 829
S E + H++E + + S ++ +D+EA R+ E + + + E L ++
Sbjct: 827 SMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAE 886
Query: 830 KCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEAT 889
+ + L LR +R+ +EL + N A+ + + +T
Sbjct: 887 IMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN-ASFLQKSIEDMTVKAEQSQQ 945
Query: 890 GSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDK--------Y 941
+ ++ ELE L E +++ + LK + A + K ++
Sbjct: 946 EAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1005
Query: 942 KDIYTELSIAKAKADCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKD 1001
D +L A+ + + L+E K A +A ++ + A + K K+ +D
Sbjct: 1006 LDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLED 1065
Query: 1002 RSCVTRQLRN 1011
+L+N
Sbjct: 1066 TKQTNAKLQN 1075
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 66.6 bits (161), Expect = 1e-10
Identities = 93/399 (23%), Positives = 172/399 (43%), Gaps = 68/399 (17%)
Query: 673 HELTSLLEKELE-------QSQKEASDLLEQNRLLQDQLRVALGR--EQSAREGYVLQAT 723
+E S L+K +E QSQ+EA+ E+ + ++ L + E S + L+A
Sbjct: 958 NENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR 1017
Query: 724 CERGFAAMEETHQKKIEDLQRQHQ-----------------RELEKLREEKDRLLAEETA 766
ER + + H++ +++LQ+ +ELE+LR++ D+ A +TA
Sbjct: 1018 YERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTA 1077
Query: 767 ATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQ 826
I + E LE ++++ + + ++++ L+ L+ ++ + + E+L+ +
Sbjct: 1078 EDAMQIMEQMTKEKTETLASLEDTKQTN-AKLQNELDTLKENNLKNVEELNKSKELLTVE 1136
Query: 827 YSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGG 886
+QK E + +E +QA Q ++Q+L+A +E N +LA E+ R R +T
Sbjct: 1137 -NQKMEE---FRKEIETLKQAAAQ---KSQQLSALQEE-NVKLAEELGRSRDEVTSHQKL 1188
Query: 887 EATGSPLAQG------------KDAYE-----------LEVLLRVKESEIQYLKQEISSL 923
E S L KDA E LL K++E++ L+ E+
Sbjct: 1189 EEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEV--- 1245
Query: 924 KDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEALGEKSPDSATV 983
T LR + ++ + L K K + + L+ QLK L S ++ T
Sbjct: 1246 -----TVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQ 1300
Query: 984 SGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSVIEQVS 1022
+ D +S DFL + V Q +N K +E +S
Sbjct: 1301 ADEDERAQESQIDFL--NSVIVDLQRKNQDLKMKVEMMS 1337
Score = 53.9 bits (128), Expect = 8e-07
Identities = 81/326 (24%), Positives = 149/326 (45%), Gaps = 55/326 (16%)
Query: 679 LEKELEQSQKEASD------LLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAME 732
L + LE S K A D LL++ LQ++L V R RE + + F A E
Sbjct: 518 LRRRLE-SNKPAGDVDMSLSLLQEISSLQEKLEVT--RTDHQRE----ITSLKEHFGARE 570
Query: 733 ETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEME-RELEKSQ 791
ETHQK+I+ L EKL +E + L ++ +++A++E + L KS+
Sbjct: 571 ETHQKEIKAL----YTATEKLSKENESLKSK-----------LEHANKENSDVIALWKSK 615
Query: 792 -RSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQ 850
+ I+S +E L+ + + L + E L Q + L+ H + L+
Sbjct: 616 LETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQ-------- 667
Query: 851 CQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEV---LLR 907
+++ E AH +E+ A ++ + + EA S L + +D + +E+ L +
Sbjct: 668 -NQQDSERAAHAKEME---ALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNK 723
Query: 908 VKESEIQYLKQEISSLKDELQTALRDK-----KYASDKYKDIYTELSIAKAKADCDISRL 962
++E+EI+ + E+ K QT + D K +K D+ L A ++ ++ +L
Sbjct: 724 LQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDL-DALRKASSEGKSEMKKL 782
Query: 963 KEQLKAATEALG----EKSPDSATVS 984
++QL+AA + + EK+ +S+ S
Sbjct: 783 RQQLEAAEKQIKHLEIEKNAESSKAS 808
Score = 38.1 bits (87), Expect = 0.043
Identities = 66/267 (24%), Positives = 112/267 (41%), Gaps = 60/267 (22%)
Query: 645 TTPLRE---EKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRL-- 699
TT L+E EKQ I L +E +R + TS + E+EQ A D +Q+ L
Sbjct: 350 TTALQEALKEKQQHIE--QLLAERDLERAEVAKATSHVG-EIEQELALARDGHDQHVLEL 406
Query: 700 --LQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIE------DLQRQHQRELE 751
DQLR + E + RE L E +E+ + E DL+ Q + E
Sbjct: 407 EAKMDQLRTMV--EAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHA 464
Query: 752 KLREEKDRLLAEETAATISAIEAMKNAHREEMERELEK------SQRSQISSVNSD---- 801
+++E + LL E+T A ++++RELE S++S+I + D
Sbjct: 465 RIKELEQSLLFEKTKA-------------DKLQRELEDTRVATVSEKSRIMELEKDLALR 511
Query: 802 ---VEALRRQ---------------YLEELQSVQRELEVLSEQYSQKCLE-NAHLAQALE 842
V LRR+ L+E+ S+Q +LEV + ++ H E
Sbjct: 512 VQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREE 571
Query: 843 AERQALRQCQRENQELNAHNQELNNRL 869
++ ++ ++L+ N+ L ++L
Sbjct: 572 THQKEIKALYTATEKLSKENESLKSKL 598
Score = 34.7 bits (78), Expect = 0.47
Identities = 64/370 (17%), Positives = 142/370 (38%), Gaps = 26/370 (7%)
Query: 650 EEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALG 709
EEK + + + +S +G + L ++LE ++K+ L E + + ++
Sbjct: 759 EEKLLDLDALRKASSEGKSEMKK------LRQQLEAAEKQIKHL-EIEKNAESSKASSIT 811
Query: 710 REQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATI 769
RE RE + + + ++ ++ ++EL+ L+E+ E +
Sbjct: 812 RELQGRELKLTNL----------QENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQR 861
Query: 770 SAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQ 829
S E + H++E + + S ++ +D+EA R+ E + + + E L ++
Sbjct: 862 SMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAE 921
Query: 830 KCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEAT 889
+ + L LR +R+ +EL + N A+ + + +T
Sbjct: 922 IMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN-ASFLQKSIEDMTVKAEQSQQ 980
Query: 890 GSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDK--------Y 941
+ ++ ELE L E +++ + LK + A + K ++
Sbjct: 981 EAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1040
Query: 942 KDIYTELSIAKAKADCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKD 1001
D +L A+ + + L+E K A +A ++ + A + K K+ +D
Sbjct: 1041 LDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLED 1100
Query: 1002 RSCVTRQLRN 1011
+L+N
Sbjct: 1101 TKQTNAKLQN 1110
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 65.9 bits (159), Expect = 2e-10
Identities = 95/443 (21%), Positives = 177/443 (39%), Gaps = 61/443 (13%)
Query: 582 ERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWH 641
E+E AR+ +E K+ L + E + +E +S L +S K + +E+
Sbjct: 486 EKELARKEQELTKK---LQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELEL 542
Query: 642 QVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQ 701
Q + E ++ L E R EL S LEK L++++ ++ DL
Sbjct: 543 QKKAILTESENKLR----DLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVH----- 593
Query: 702 DQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLL 761
A + H K+I + +H+ ELE L+ ++D L
Sbjct: 594 --------------------------LEAEKNKHNKEITVMVEKHKTELESLKHQQDALW 627
Query: 762 AEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELE 821
E+ + RE+ E+E E + + + +E + + LE+L Q ELE
Sbjct: 628 TEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELE 687
Query: 822 VLSEQYSQKCLENAHLAQALEAERQALR-QCQRENQELNAHNQELNNRLAAEITRLRTLL 880
LS + S+ L+ H LE E L+ Q + QEL A E N ++ + +
Sbjct: 688 SLSSELSE-VLKARH---KLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI--IK 741
Query: 881 TGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDK 940
+ + T L +LE+LL+ ++ ++ + + +L+ +++ + + + AS K
Sbjct: 742 EHEVSIQRTEKALKD--QINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAK 799
Query: 941 YKDIYTELSIAKAKADCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSK--SNPDFL 998
D++ S EQ KA E L + + I+ +K + +
Sbjct: 800 L-DVFQSYQ----------SATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQ 848
Query: 999 KKDRSCVTRQLRNIRSKSVIEQV 1021
KKD C I+ + +++Q+
Sbjct: 849 KKD-VCTELDAHKIQVQDLMQQL 870
Score = 56.2 bits (134), Expect = 2e-07
Identities = 91/419 (21%), Positives = 172/419 (41%), Gaps = 80/419 (19%)
Query: 627 LKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQS 686
LK H HVE +E R E ++ A L +THE T E++L Q
Sbjct: 772 LKEHQAHVE------NLEADIKRSEGELQQASAKLDVFQSYQS-ATHEQTKAYEEQLAQL 824
Query: 687 QKEASDLLEQNRLLQDQLRVALGREQSA---REGYVLQ------------ATCERGFAAM 731
Q++ DL + LL Q+ +++ + + +Q + E+ ++
Sbjct: 825 QQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSL 884
Query: 732 EETHQKKIEDLQRQHQRELEKLREEKDRLLA---------EETAATISAIEAMKNAHREE 782
+ ++ K+ED ++ ++ + L E+++ +L E +SA E + EE
Sbjct: 885 TQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEE 944
Query: 783 MERELEKSQRSQISSVNSDV----EALRRQYLEELQSVQRELEVLSEQYSQKCLE-NAHL 837
E + K+Q ++ V E L+++ L++ +++ELE + + SQK + NA +
Sbjct: 945 YETKF-KNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKM 1003
Query: 838 AQALEAERQALRQC-------QRENQE--LNAHNQELNNRLAAEITRLRTLLTGDGGGEA 888
+ +A + Q+E E H +ELN+ ++ +L
Sbjct: 1004 LEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLN----------- 1052
Query: 889 TGSPLAQGKDAYEL-EVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTE 947
Q ++ E+ E+ L+ KE E+ LKQ+I E + + K+I T
Sbjct: 1053 -----QQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKE----------EMNKEI-TW 1096
Query: 948 LSIAKAKADCDISRLKEQLKAATEALGEKSPDSATVSGY------DIMKSKSNPDFLKK 1000
L K D ++ L+EQLK + + + D + + D+ KS FL++
Sbjct: 1097 LKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQE 1155
Score = 53.9 bits (128), Expect = 8e-07
Identities = 102/479 (21%), Positives = 198/479 (41%), Gaps = 60/479 (12%)
Query: 484 PTTAPDVTS-SLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRSKT 542
P +A +V + + EE + C +T + L E E+ R + + E S
Sbjct: 1709 PRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEK--EKLLQRVGQEKEETVSSH 1766
Query: 543 FDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLDAT 602
F+ + QER+ + A+ + ++ G L+ E EE+ K++ ++
Sbjct: 1767 FE-------MRCQYQERLIKLEHAEAKQH-EDQSMIGHLQEEL----EEKNKKYSLI--- 1811
Query: 603 DGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLS 662
A +E + + NV ++++ + E T E+++ L
Sbjct: 1812 -------VAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLV 1864
Query: 663 SEDGGDRLSTHELTSLLEK--ELEQ--SQKEASDLLEQN-------RLLQDQLRVALGRE 711
+ R+ ELTS EK L+Q + + ++LLE+N L+Q +L + +
Sbjct: 1865 RQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQ 1924
Query: 712 QSAREGYVLQATCERGFAAMEETH-QKKIEDLQRQHQRELEKLREEKDRLLAEETAATIS 770
+ E + A E+ E QK + L+++HQ+ELE L++E D+ E+
Sbjct: 1925 HNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQE 1984
Query: 771 AIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQK 830
+E N+ +++ RE +Q++ ++E ++ + + Q V+ E L E + ++
Sbjct: 1985 DLELKHNSTLKQLMREF----NTQLAQKEQELEMTIKETINKAQEVEAE---LLESHQEE 2037
Query: 831 CLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTG-DGGGEAT 889
N L + E + R +R + L+A +E+ ++ T+L L E
Sbjct: 2038 --TNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQE 2095
Query: 890 GSPLAQGKDAYELEVLLRVKESEI-------QYLKQEISSLKDELQTALRDKKYASDKY 941
+P EL+ L K + I Q +++I +L+D L KKY + Y
Sbjct: 2096 ENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRL------KKYEKNVY 2148
Score = 43.9 bits (102), Expect = 8e-04
Identities = 92/449 (20%), Positives = 179/449 (39%), Gaps = 66/449 (14%)
Query: 626 DLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQ 685
+L+ N+ V+ ++ + L E +A + +E + L+ + EKE +
Sbjct: 1607 ELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQY 1666
Query: 686 SQKEASDLLEQNRLLQDQ------LRVALGREQSAREGYVLQATCERGFAA--------- 730
+ S L E N LQ++ L L +S++ ++ + AA
Sbjct: 1667 KKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADS 1726
Query: 731 ---MEETHQKKIEDLQR---QHQRELEKLREEKDRLLAEETAATISAIEAM-KNAHREEM 783
+++T+++KI LQR + ++ L+++ +EK+ ++ E + K H E
Sbjct: 1727 QGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAK 1786
Query: 784 ERELEKSQRSQISSVNSDVEALRRQY-LEELQSVQRE-----------LEVLSEQYSQKC 831
+ E +S I + ++E ++Y L Q V++E LE + + +
Sbjct: 1787 QHE----DQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTL 1842
Query: 832 LENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGG----- 886
E Q LE + + L C +E+ H E+ L ++ +L+ L DG
Sbjct: 1843 QEKELTCQILEQKIKELDSCLVRQKEV--HRVEM-EELTSKYEKLQALQQMDGRNKPTEL 1899
Query: 887 ------EATGSPLAQGK-------DAYELEVLLRVKESEIQYLKQEISSLKDELQTALRD 933
E + S L Q K +LE L E E Q L +EI L+ +L+ ++
Sbjct: 1900 LEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKE 1959
Query: 934 KKYASDKYKDIY---TELSIAKAKADCDI---SRLKEQLKAATEALGEKSPDSATVSGYD 987
+ + K Y E I + + D ++ S LK+ ++ L +K +
Sbjct: 1960 HQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKET 2019
Query: 988 IMKSKS-NPDFLKKDRSCVTRQLRNIRSK 1015
I K++ + L+ + + L+ I K
Sbjct: 2020 INKAQEVEAELLESHQEETNQLLKKIAEK 2048
Score = 43.1 bits (100), Expect = 0.001
Identities = 92/428 (21%), Positives = 180/428 (42%), Gaps = 54/428 (12%)
Query: 627 LKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQS 686
LK H +E++ E T L+E+ + + + +E+ D+ ELTS L+ E+
Sbjct: 1132 LKAHLEKLEVDLNKSLKENTFLQEQ----LVELKMLAEE--DKRKVSELTSKLKTTDEEF 1185
Query: 687 QKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQH 746
Q S + N+ L+D + ++ S L C++ A +E + I +
Sbjct: 1186 QSLKSSHEKSNKSLED--KSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKT 1243
Query: 747 QRELEKLREEKDRLLAEETA-----ATISAIEAMKNAHREEME----------RELEKSQ 791
L ++ + R + A T+S +EA EE +LE+ +
Sbjct: 1244 NAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKE 1303
Query: 792 RSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQC 851
+QI S+ +D+E+L + E +++Q+E + S+K L + L A+
Sbjct: 1304 -NQIKSMKADIESL----VTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLM 1358
Query: 852 QRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKES 911
+ E +E L+ +L +L+ ++ EA S L + D + E+L +V++
Sbjct: 1359 KEELKEKKVEISSLSKQLTDLNVQLQNSIS-LSEKEAAISSLRKQYDEEKCELLDQVQDL 1417
Query: 912 EIQ---YLKQEISSLK--DELQTALRD-KKYASDKY-------KDIYTELSIAKAKA--- 955
+ K++IS+L+ D+ + KK A ++ K++ +L + +A
Sbjct: 1418 SFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEK 1477
Query: 956 DCDISRLKEQLKAATEAL----GEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRN 1011
D I+ LKE+L + GE D + + K +SN + K ++ +L +
Sbjct: 1478 DEQINLLKEELDQQNKRFDCLKGEMEDDKSKME-----KKESNLETELKSQTARIMELED 1532
Query: 1012 IRSKSVIE 1019
++ IE
Sbjct: 1533 HITQKTIE 1540
Score = 37.0 bits (84), Expect = 0.095
Identities = 52/233 (22%), Positives = 98/233 (42%), Gaps = 30/233 (12%)
Query: 779 HREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLEN-AHL 837
++E++ + L + +RS +SS L Y + LQ +++L+ + Q K L A L
Sbjct: 135 NKEQLIQRLRRMERS-LSSYRGKYSELVTAY-QMLQREKKKLQGILSQSQDKSLRRIAEL 192
Query: 838 AQALEAERQALRQCQRE----NQELNAHNQELNNRLAAEITRLRT--------------- 878
+ L+ ++QA + Q E +E + + L +++ RLR
Sbjct: 193 REELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLE 252
Query: 879 ----LLTGDGGGEATGSPLAQ-GKDAYELEVL-LRVKESE--IQYLKQEISSLKDELQTA 930
+ T + E+ G P+ + G LE L RVK E ++ K+ I S K++
Sbjct: 253 PQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLL 312
Query: 931 LRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEALGEKSPDSATV 983
+K+ ++ + EL K + ++L QL+ A + + D V
Sbjct: 313 TSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMV 365
Score = 33.9 bits (76), Expect = 0.81
Identities = 52/241 (21%), Positives = 100/241 (41%), Gaps = 55/241 (22%)
Query: 735 HQKKIEDLQRQHQRELEKL--REEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQR 792
HQ +++LQ Q + + ++ ++E+ LL EE + +K EME + K ++
Sbjct: 1456 HQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKG----EMEDDKSKMEK 1511
Query: 793 SQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQ 852
+ S++E EL+S + L + +QK +E L + L+
Sbjct: 1512 KE-----SNLET-------ELKSQTARIMELEDHITQKTIEIESLNEVLK---------- 1549
Query: 853 RENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESE 912
NQ+ + ++EL +L L + KD RVKE+E
Sbjct: 1550 NYNQQKDIEHKELVQKLQHF------------------QELGEEKDN-------RVKEAE 1584
Query: 913 --IQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAAT 970
I L+ ++ S+K EL+T ++ ++ + K EL + + + + + +LK
Sbjct: 1585 EKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKA 1644
Query: 971 E 971
E
Sbjct: 1645 E 1645
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.127 0.359
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,108,361
Number of Sequences: 37866
Number of extensions: 2173514
Number of successful extensions: 23040
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 244
Number of HSP's successfully gapped in prelim test: 1562
Number of HSP's that attempted gapping in prelim test: 14578
Number of HSP's gapped (non-prelim): 6844
length of query: 1025
length of database: 18,247,518
effective HSP length: 112
effective length of query: 913
effective length of database: 14,006,526
effective search space: 12787958238
effective search space used: 12787958238
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.