Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 5032287
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]
(3681 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens] 7278 0.0
gi|5032281 dystrophin Dp427c isoform [Homo sapiens] 7268 0.0
gi|5032283 dystrophin Dp427m isoform [Homo sapiens] 7266 0.0
gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens] 7041 0.0
gi|5032285 dystrophin Dp427l isoform [Homo sapiens] 7041 0.0
gi|5032291 dystrophin Dp260-2 isoform [Homo sapiens] 4598 0.0
gi|150036268 dystrophin Dp260-1 isoform [Homo sapiens] 4597 0.0
gi|5032293 dystrophin Dp140 isoform [Homo sapiens] 2452 0.0
gi|5032309 dystrophin Dp140b isoform [Homo sapiens] 2427 0.0
gi|5032311 dystrophin Dp140ab isoform [Homo sapiens] 2390 0.0
gi|5032313 dystrophin Dp140bc isoform [Homo sapiens] 1908 0.0
gi|5032295 dystrophin Dp116 isoform [Homo sapiens] 1907 0.0
gi|5032307 dystrophin Dp140c isoform [Homo sapiens] 1888 0.0
gi|110611228 utrophin [Homo sapiens] 1744 0.0
gi|5032297 dystrophin Dp71 isoform [Homo sapiens] 1240 0.0
gi|5032299 dystrophin Dp71b isoform [Homo sapiens] 1214 0.0
gi|5032301 dystrophin Dp71a isoform [Homo sapiens] 1203 0.0
gi|5032303 dystrophin Dp71ab isoform [Homo sapiens] 1177 0.0
gi|148539558 dystrophin related protein 2 [Homo sapiens] 996 0.0
gi|5032305 dystrophin Dp40 isoform [Homo sapiens] 693 0.0
gi|33188443 microfilament and actin filament cross-linker protei... 370 e-101
gi|33188445 microfilament and actin filament cross-linker protei... 370 e-101
gi|221316624 dystonin isoform 4 [Homo sapiens] 325 7e-88
gi|221316622 dystonin isoform 3 [Homo sapiens] 325 7e-88
gi|221316618 dystonin isoform 2 [Homo sapiens] 325 7e-88
gi|34577047 dystonin isoform 1 [Homo sapiens] 325 7e-88
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] 325 7e-88
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof... 320 1e-86
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo... 313 2e-84
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 301 6e-81
>gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]
Length = 3681
Score = 7278 bits (18883), Expect = 0.0
Identities = 3681/3681 (100%), Positives = 3681/3681 (100%)
Query: 1 MSEVSSDEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPK 60
MSEVSSDEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPK
Sbjct: 1 MSEVSSDEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPK 60
Query: 61 EKGSTRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVM 120
EKGSTRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVM
Sbjct: 61 EKGSTRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVM 120
Query: 121 KNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWN 180
KNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWN
Sbjct: 121 KNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWN 180
Query: 181 SVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVS 240
SVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVS
Sbjct: 181 SVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVS 240
Query: 241 IEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQA 300
IEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQA
Sbjct: 241 IEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQA 300
Query: 301 AYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQA 360
AYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQA
Sbjct: 301 AYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQA 360
Query: 361 QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQM 420
QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQM
Sbjct: 361 QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQM 420
Query: 421 NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLE 480
NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLE
Sbjct: 421 NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLE 480
Query: 481 DLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANIC 540
DLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANIC
Sbjct: 481 DLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANIC 540
Query: 541 RWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLA 600
RWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLA
Sbjct: 541 RWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLA 600
Query: 601 VLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQ 660
VLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQ
Sbjct: 601 VLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQ 660
Query: 661 ISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRL 720
ISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRL
Sbjct: 661 ISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRL 720
Query: 721 DVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSA 780
DVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSA
Sbjct: 721 DVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSA 780
Query: 781 QALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ 840
QALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ
Sbjct: 781 QALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ 840
Query: 841 MTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGP 900
MTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGP
Sbjct: 841 MTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGP 900
Query: 901 MFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSI 960
MFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSI
Sbjct: 901 MFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSI 960
Query: 961 PQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEE 1020
PQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEE
Sbjct: 961 PQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEE 1020
Query: 1021 IEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEIL 1080
IEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEIL
Sbjct: 1021 IEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEIL 1080
Query: 1081 KKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQ 1140
KKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQ
Sbjct: 1081 KKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQ 1140
Query: 1141 VYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAK 1200
VYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAK
Sbjct: 1141 VYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAK 1200
Query: 1201 EEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEV 1260
EEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEV
Sbjct: 1201 EEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEV 1260
Query: 1261 WACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIR 1320
WACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIR
Sbjct: 1261 WACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIR 1320
Query: 1321 ILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQE 1380
ILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQE
Sbjct: 1321 ILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQE 1380
Query: 1381 SLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQI 1440
SLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQI
Sbjct: 1381 SLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQI 1440
Query: 1441 DVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNH 1500
DVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNH
Sbjct: 1441 DVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNH 1500
Query: 1501 CVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQ 1560
CVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQ
Sbjct: 1501 CVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQ 1560
Query: 1561 QLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQ 1620
QLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQ
Sbjct: 1561 QLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQ 1620
Query: 1621 KVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETF 1680
KVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETF
Sbjct: 1621 KVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETF 1680
Query: 1681 DQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMAN 1740
DQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMAN
Sbjct: 1681 DQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMAN 1740
Query: 1741 RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQG 1800
RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQG
Sbjct: 1741 RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQG 1800
Query: 1801 VNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1860
VNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL
Sbjct: 1801 VNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1860
Query: 1861 RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKE 1920
RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKE
Sbjct: 1861 RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKE 1920
Query: 1921 ELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMV 1980
ELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMV
Sbjct: 1921 ELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMV 1980
Query: 1981 MTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDS 2040
MTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDS
Sbjct: 1981 MTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDS 2040
Query: 2041 LQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVE 2100
LQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVE
Sbjct: 2041 LQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVE 2100
Query: 2101 KWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNA 2160
KWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNA
Sbjct: 2101 KWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNA 2160
Query: 2161 TGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFV 2220
TGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFV
Sbjct: 2161 TGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFV 2220
Query: 2221 LWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPIS 2280
LWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPIS
Sbjct: 2221 LWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPIS 2280
Query: 2281 PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 2340
PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL
Sbjct: 2281 PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 2340
Query: 2341 SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE 2400
SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE
Sbjct: 2341 SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE 2400
Query: 2401 DLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSS 2460
DLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSS
Sbjct: 2401 DLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSS 2460
Query: 2461 LMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRR 2520
LMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRR
Sbjct: 2461 LMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRR 2520
Query: 2521 PQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQ 2580
PQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQ
Sbjct: 2521 PQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQ 2580
Query: 2581 WLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLA 2640
WLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLA
Sbjct: 2581 WLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLA 2640
Query: 2641 LKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAW 2700
LKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAW
Sbjct: 2641 LKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAW 2700
Query: 2701 LTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILR 2760
LTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILR
Sbjct: 2701 LTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILR 2760
Query: 2761 SLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLK 2820
SLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLK
Sbjct: 2761 SLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLK 2820
Query: 2821 DDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKL 2880
DDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKL
Sbjct: 2821 DDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKL 2880
Query: 2881 YQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD 2940
YQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD
Sbjct: 2881 YQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD 2940
Query: 2941 ELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 3000
ELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT
Sbjct: 2941 ELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 3000
Query: 3001 LGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERA 3060
LGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERA
Sbjct: 3001 LGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERA 3060
Query: 3061 ISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLL 3120
ISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLL
Sbjct: 3061 ISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLL 3120
Query: 3121 SLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLN 3180
SLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLN
Sbjct: 3121 SLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLN 3180
Query: 3181 VYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQI 3240
VYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQI
Sbjct: 3181 VYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQI 3240
Query: 3241 PRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAA 3300
PRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAA
Sbjct: 3241 PRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAA 3300
Query: 3301 ETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTT 3360
ETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTT
Sbjct: 3301 ETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTT 3360
Query: 3361 SGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPAS 3420
SGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPAS
Sbjct: 3361 SGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPAS 3420
Query: 3421 SPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSP 3480
SPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSP
Sbjct: 3421 SPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSP 3480
Query: 3481 LSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPE 3540
LSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPE
Sbjct: 3481 LSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPE 3540
Query: 3541 MMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEA 3600
MMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEA
Sbjct: 3541 MMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEA 3600
Query: 3601 KVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLN 3660
KVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLN
Sbjct: 3601 KVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLN 3660
Query: 3661 NSFPSSRGRNTPGKPMREDTM 3681
NSFPSSRGRNTPGKPMREDTM
Sbjct: 3661 NSFPSSRGRNTPGKPMREDTM 3681
>gi|5032281 dystrophin Dp427c isoform [Homo sapiens]
Length = 3677
Score = 7268 bits (18857), Expect = 0.0
Identities = 3675/3675 (100%), Positives = 3675/3675 (100%)
Query: 7 DEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTR 66
DEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTR
Sbjct: 3 DEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTR 62
Query: 67 VHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAG 126
VHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAG
Sbjct: 63 VHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAG 122
Query: 127 LQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQ 186
LQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQ
Sbjct: 123 LQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQ 182
Query: 187 SATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQE 246
SATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQE
Sbjct: 183 SATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQE 242
Query: 247 VEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTS 306
VEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTS
Sbjct: 243 VEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTS 302
Query: 307 DPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISN 366
DPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISN
Sbjct: 303 DPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISN 362
Query: 367 DVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSR 426
DVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSR
Sbjct: 363 DVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSR 422
Query: 427 WECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQV 486
WECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQV
Sbjct: 423 WECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQV 482
Query: 487 QQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDR 546
QQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDR
Sbjct: 483 QQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDR 542
Query: 547 WVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADL 606
WVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADL
Sbjct: 543 WVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADL 602
Query: 607 EKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVT 666
EKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVT
Sbjct: 603 EKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVT 662
Query: 667 TTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITE 726
TTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITE
Sbjct: 663 TTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITE 722
Query: 727 LHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQ 786
LHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQ
Sbjct: 723 LHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQ 782
Query: 787 MVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAE 846
MVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAE
Sbjct: 783 MVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAE 842
Query: 847 NWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDAD 906
NWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDAD
Sbjct: 843 NWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDAD 902
Query: 907 FVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVT 966
FVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVT
Sbjct: 903 FVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVT 962
Query: 967 DYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWK 1026
DYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWK
Sbjct: 963 DYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWK 1022
Query: 1027 KLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQ 1086
KLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQ
Sbjct: 1023 KLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQ 1082
Query: 1087 CRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKE 1146
CRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKE
Sbjct: 1083 CRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKE 1142
Query: 1147 ALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQK 1206
ALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQK
Sbjct: 1143 ALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQK 1202
Query: 1207 EAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHE 1266
EAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHE
Sbjct: 1203 EAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHE 1262
Query: 1267 LLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTL 1326
LLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTL
Sbjct: 1263 LLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTL 1322
Query: 1327 TDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFID 1386
TDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFID
Sbjct: 1323 TDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFID 1382
Query: 1387 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKK 1446
KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKK
Sbjct: 1383 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKK 1442
Query: 1447 LQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 1506
LQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK
Sbjct: 1443 LQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 1502
Query: 1507 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 1566
SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL
Sbjct: 1503 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 1562
Query: 1567 KLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKS 1626
KLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKS
Sbjct: 1563 KLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKS 1622
Query: 1627 ITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDH 1686
ITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDH
Sbjct: 1623 ITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDH 1682
Query: 1687 ITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCR 1746
ITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCR
Sbjct: 1683 ITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCR 1742
Query: 1747 KLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEE 1806
KLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEE
Sbjct: 1743 KLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEE 1802
Query: 1807 DFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRK 1866
DFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRK
Sbjct: 1803 DFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRK 1862
Query: 1867 KALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVR 1926
KALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVR
Sbjct: 1863 KALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVR 1922
Query: 1927 RQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMP 1986
RQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMP
Sbjct: 1923 RQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMP 1982
Query: 1987 LEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSG 2046
LEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSG
Sbjct: 1983 LEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSG 2042
Query: 2047 RIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFH 2106
RIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFH
Sbjct: 2043 RIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFH 2102
Query: 2107 YDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEII 2166
YDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEII
Sbjct: 2103 YDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEII 2162
Query: 2167 QQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA 2226
QQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA
Sbjct: 2163 QQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA 2222
Query: 2227 DNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDK 2286
DNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDK
Sbjct: 2223 DNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDK 2282
Query: 2287 LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQ 2346
LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQ
Sbjct: 2283 LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQ 2342
Query: 2347 LEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEW 2406
LEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEW
Sbjct: 2343 LEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEW 2402
Query: 2407 KAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVP 2466
KAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVP
Sbjct: 2403 KAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVP 2462
Query: 2467 ALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEEL 2526
ALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEEL
Sbjct: 2463 ALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEEL 2522
Query: 2527 ITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKE 2586
ITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKE
Sbjct: 2523 ITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKE 2582
Query: 2587 EAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRD 2646
EAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRD
Sbjct: 2583 EAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRD 2642
Query: 2647 YSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAET 2706
YSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAET
Sbjct: 2643 YSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAET 2702
Query: 2707 TANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD 2766
TANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD
Sbjct: 2703 TANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD 2762
Query: 2767 DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR 2826
DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR
Sbjct: 2763 DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR 2822
Query: 2827 QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE 2886
QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE
Sbjct: 2823 QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE 2882
Query: 2887 LPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKL 2946
LPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKL
Sbjct: 2883 LPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKL 2942
Query: 2947 RQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLS 3006
RQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLS
Sbjct: 2943 RQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLS 3002
Query: 3007 PYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKV 3066
PYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKV
Sbjct: 3003 PYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKV 3062
Query: 3067 PYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAAC 3126
PYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAAC
Sbjct: 3063 PYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAAC 3122
Query: 3127 DALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR 3186
DALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR
Sbjct: 3123 DALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR 3182
Query: 3187 TGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGE 3246
TGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGE
Sbjct: 3183 TGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGE 3242
Query: 3247 VASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQ 3306
VASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQ
Sbjct: 3243 VASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQ 3302
Query: 3307 AKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVR 3366
AKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVR
Sbjct: 3303 AKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVR 3362
Query: 3367 DFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSH 3426
DFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSH
Sbjct: 3363 DFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSH 3422
Query: 3427 DDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRS 3486
DDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRS
Sbjct: 3423 DDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRS 3482
Query: 3487 PAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSP 3546
PAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSP
Sbjct: 3483 PAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSP 3542
Query: 3547 QSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTT 3606
QSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTT
Sbjct: 3543 QSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTT 3602
Query: 3607 VSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSS 3666
VSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSS
Sbjct: 3603 VSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSS 3662
Query: 3667 RGRNTPGKPMREDTM 3681
RGRNTPGKPMREDTM
Sbjct: 3663 RGRNTPGKPMREDTM 3677
>gi|5032283 dystrophin Dp427m isoform [Homo sapiens]
Length = 3685
Score = 7266 bits (18851), Expect = 0.0
Identities = 3674/3674 (100%), Positives = 3674/3674 (100%)
Query: 8 EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRV 67
EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRV
Sbjct: 12 EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRV 71
Query: 68 HALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGL 127
HALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGL
Sbjct: 72 HALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGL 131
Query: 128 QQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQS 187
QQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQS
Sbjct: 132 QQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQS 191
Query: 188 ATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEV 247
ATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEV
Sbjct: 192 ATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEV 251
Query: 248 EMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSD 307
EMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSD
Sbjct: 252 EMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSD 311
Query: 308 PTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISND 367
PTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISND
Sbjct: 312 PTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISND 371
Query: 368 VEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRW 427
VEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRW
Sbjct: 372 VEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRW 431
Query: 428 ECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQ 487
ECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQ
Sbjct: 432 ECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQ 491
Query: 488 QHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRW 547
QHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRW
Sbjct: 492 QHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRW 551
Query: 548 VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE 607
VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE
Sbjct: 552 VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE 611
Query: 608 KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 667
KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT
Sbjct: 612 KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 671
Query: 668 TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 727
TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL
Sbjct: 672 TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 731
Query: 728 HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 787
HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM
Sbjct: 732 HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 791
Query: 788 VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN 847
VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN
Sbjct: 792 VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN 851
Query: 848 WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 907
WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF
Sbjct: 852 WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 911
Query: 908 VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD 967
VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD
Sbjct: 912 VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD 971
Query: 968 YEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 1027
YEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK
Sbjct: 972 YEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 1031
Query: 1028 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 1087
LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC
Sbjct: 1032 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 1091
Query: 1088 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1147
RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA
Sbjct: 1092 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1151
Query: 1148 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1207
LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE
Sbjct: 1152 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1211
Query: 1208 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1267
AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL
Sbjct: 1212 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1271
Query: 1268 LSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLT 1327
LSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLT
Sbjct: 1272 LSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLT 1331
Query: 1328 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1387
DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK
Sbjct: 1332 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1391
Query: 1388 QLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL 1447
QLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL
Sbjct: 1392 QLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL 1451
Query: 1448 QDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKS 1507
QDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKS
Sbjct: 1452 QDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKS 1511
Query: 1508 LSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLK 1567
LSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLK
Sbjct: 1512 LSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLK 1571
Query: 1568 LSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSI 1627
LSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSI
Sbjct: 1572 LSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSI 1631
Query: 1628 TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHI 1687
TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHI
Sbjct: 1632 TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHI 1691
Query: 1688 TKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRK 1747
TKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRK
Sbjct: 1692 TKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRK 1751
Query: 1748 LVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEED 1807
LVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEED
Sbjct: 1752 LVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEED 1811
Query: 1808 FNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKK 1867
FNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKK
Sbjct: 1812 FNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKK 1871
Query: 1868 ALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRR 1927
ALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRR
Sbjct: 1872 ALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRR 1931
Query: 1928 QAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPL 1987
QAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPL
Sbjct: 1932 QAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPL 1991
Query: 1988 EISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGR 2047
EISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGR
Sbjct: 1992 EISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGR 2051
Query: 2048 IDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHY 2107
IDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHY
Sbjct: 2052 IDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHY 2111
Query: 2108 DIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQ 2167
DIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQ
Sbjct: 2112 DIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQ 2171
Query: 2168 QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 2227
QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD
Sbjct: 2172 QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 2231
Query: 2228 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2287
NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL
Sbjct: 2232 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2291
Query: 2288 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2347
ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL
Sbjct: 2292 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2351
Query: 2348 EIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWK 2407
EIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWK
Sbjct: 2352 EIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWK 2411
Query: 2408 AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA 2467
AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA
Sbjct: 2412 AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA 2471
Query: 2468 LADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELI 2527
LADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELI
Sbjct: 2472 LADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELI 2531
Query: 2528 TAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEE 2587
TAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEE
Sbjct: 2532 TAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEE 2591
Query: 2588 AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 2647
AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY
Sbjct: 2592 AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 2651
Query: 2648 SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 2707
SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT
Sbjct: 2652 SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 2711
Query: 2708 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 2767
ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD
Sbjct: 2712 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 2771
Query: 2768 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2827
AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ
Sbjct: 2772 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2831
Query: 2828 APIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL 2887
APIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL
Sbjct: 2832 APIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL 2891
Query: 2888 PPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLR 2947
PPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLR
Sbjct: 2892 PPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLR 2951
Query: 2948 QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSP 3007
QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSP
Sbjct: 2952 QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSP 3011
Query: 3008 YNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVP 3067
YNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVP
Sbjct: 3012 YNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVP 3071
Query: 3068 YYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACD 3127
YYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACD
Sbjct: 3072 YYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACD 3131
Query: 3128 ALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRT 3187
ALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRT
Sbjct: 3132 ALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRT 3191
Query: 3188 GRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEV 3247
GRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEV
Sbjct: 3192 GRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEV 3251
Query: 3248 ASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQA 3307
ASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQA
Sbjct: 3252 ASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQA 3311
Query: 3308 KCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRD 3367
KCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRD
Sbjct: 3312 KCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRD 3371
Query: 3368 FAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHD 3427
FAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHD
Sbjct: 3372 FAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHD 3431
Query: 3428 DTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSP 3487
DTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSP
Sbjct: 3432 DTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSP 3491
Query: 3488 AQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQ 3547
AQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQ
Sbjct: 3492 AQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQ 3551
Query: 3548 SPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTV 3607
SPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTV
Sbjct: 3552 SPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTV 3611
Query: 3608 SSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSR 3667
SSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSR
Sbjct: 3612 SSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSR 3671
Query: 3668 GRNTPGKPMREDTM 3681
GRNTPGKPMREDTM
Sbjct: 3672 GRNTPGKPMREDTM 3685
>gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens]
Length = 3562
Score = 7041 bits (18267), Expect = 0.0
Identities = 3562/3562 (100%), Positives = 3562/3562 (100%)
Query: 120 MKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDW 179
MKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDW
Sbjct: 1 MKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDW 60
Query: 180 NSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQV 239
NSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQV
Sbjct: 61 NSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQV 120
Query: 240 SIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQ 299
SIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQ
Sbjct: 121 SIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQ 180
Query: 300 AAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQ 359
AAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQ
Sbjct: 181 AAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQ 240
Query: 360 AQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQ 419
AQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQ
Sbjct: 241 AQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQ 300
Query: 420 MNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDL 479
MNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDL
Sbjct: 301 MNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDL 360
Query: 480 EDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANI 539
EDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANI
Sbjct: 361 EDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANI 420
Query: 540 CRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKL 599
CRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKL
Sbjct: 421 CRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKL 480
Query: 600 AVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTA 659
AVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTA
Sbjct: 481 AVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTA 540
Query: 660 QISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 719
QISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR
Sbjct: 541 QISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 600
Query: 720 LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 779
LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS
Sbjct: 601 LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 660
Query: 780 AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE 839
AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE
Sbjct: 661 AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE 720
Query: 840 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 899
QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG
Sbjct: 721 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 780
Query: 900 PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLS 959
PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLS
Sbjct: 781 PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLS 840
Query: 960 IPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFE 1019
IPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFE
Sbjct: 841 IPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFE 900
Query: 1020 EIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEI 1079
EIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEI
Sbjct: 901 EIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEI 960
Query: 1080 LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1139
LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ
Sbjct: 961 LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1020
Query: 1140 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1199
QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA
Sbjct: 1021 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1080
Query: 1200 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEE 1259
KEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEE
Sbjct: 1081 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEE 1140
Query: 1260 VWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQI 1319
VWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQI
Sbjct: 1141 VWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQI 1200
Query: 1320 RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ 1379
RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ
Sbjct: 1201 RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ 1260
Query: 1380 ESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQ 1439
ESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQ
Sbjct: 1261 ESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQ 1320
Query: 1440 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1499
IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN
Sbjct: 1321 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1380
Query: 1500 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1559
HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK
Sbjct: 1381 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1440
Query: 1560 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1619
QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK
Sbjct: 1441 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1500
Query: 1620 QKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 1679
QKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET
Sbjct: 1501 QKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 1560
Query: 1680 FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 1739
FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA
Sbjct: 1561 FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 1620
Query: 1740 NRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQ 1799
NRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQ
Sbjct: 1621 NRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQ 1680
Query: 1800 GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKD 1859
GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKD
Sbjct: 1681 GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKD 1740
Query: 1860 LRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK 1919
LRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK
Sbjct: 1741 LRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK 1800
Query: 1920 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 1979
EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM
Sbjct: 1801 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 1860
Query: 1980 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKD 2039
VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKD
Sbjct: 1861 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKD 1920
Query: 2040 SLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSV 2099
SLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSV
Sbjct: 1921 SLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSV 1980
Query: 2100 EKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLN 2159
EKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLN
Sbjct: 1981 EKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLN 2040
Query: 2160 ATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEF 2219
ATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEF
Sbjct: 2041 ATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEF 2100
Query: 2220 VLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI 2279
VLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI
Sbjct: 2101 VLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI 2160
Query: 2280 SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLW 2339
SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLW
Sbjct: 2161 SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLW 2220
Query: 2340 LSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKL 2399
LSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKL
Sbjct: 2221 LSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKL 2280
Query: 2400 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2459
EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS
Sbjct: 2281 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2340
Query: 2460 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2519
SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR
Sbjct: 2341 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2400
Query: 2520 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2579
RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST
Sbjct: 2401 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2460
Query: 2580 QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL 2639
QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL
Sbjct: 2461 QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL 2520
Query: 2640 ALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLA 2699
ALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLA
Sbjct: 2521 ALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLA 2580
Query: 2700 WLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKIL 2759
WLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKIL
Sbjct: 2581 WLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKIL 2640
Query: 2760 RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQL 2819
RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQL
Sbjct: 2641 RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQL 2700
Query: 2820 KDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEK 2879
KDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEK
Sbjct: 2701 KDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEK 2760
Query: 2880 LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT 2939
LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT
Sbjct: 2761 LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT 2820
Query: 2940 DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT 2999
DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT
Sbjct: 2821 DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT 2880
Query: 3000 TLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWER 3059
TLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWER
Sbjct: 2881 TLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWER 2940
Query: 3060 AISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDL 3119
AISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDL
Sbjct: 2941 AISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDL 3000
Query: 3120 LSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLL 3179
LSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLL
Sbjct: 3001 LSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLL 3060
Query: 3180 NVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQ 3239
NVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQ
Sbjct: 3061 NVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQ 3120
Query: 3240 IPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAA 3299
IPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAA
Sbjct: 3121 IPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAA 3180
Query: 3300 AETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPT 3359
AETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPT
Sbjct: 3181 AETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPT 3240
Query: 3360 TSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPA 3419
TSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPA
Sbjct: 3241 TSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPA 3300
Query: 3420 SSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDS 3479
SSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDS
Sbjct: 3301 SSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDS 3360
Query: 3480 PLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPP 3539
PLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPP
Sbjct: 3361 PLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPP 3420
Query: 3540 EMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAE 3599
EMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAE
Sbjct: 3421 EMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAE 3480
Query: 3600 AKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQL 3659
AKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQL
Sbjct: 3481 AKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQL 3540
Query: 3660 NNSFPSSRGRNTPGKPMREDTM 3681
NNSFPSSRGRNTPGKPMREDTM
Sbjct: 3541 NNSFPSSRGRNTPGKPMREDTM 3562
>gi|5032285 dystrophin Dp427l isoform [Homo sapiens]
Length = 3562
Score = 7041 bits (18267), Expect = 0.0
Identities = 3562/3562 (100%), Positives = 3562/3562 (100%)
Query: 120 MKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDW 179
MKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDW
Sbjct: 1 MKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDW 60
Query: 180 NSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQV 239
NSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQV
Sbjct: 61 NSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQV 120
Query: 240 SIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQ 299
SIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQ
Sbjct: 121 SIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQ 180
Query: 300 AAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQ 359
AAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQ
Sbjct: 181 AAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQ 240
Query: 360 AQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQ 419
AQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQ
Sbjct: 241 AQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQ 300
Query: 420 MNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDL 479
MNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDL
Sbjct: 301 MNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDL 360
Query: 480 EDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANI 539
EDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANI
Sbjct: 361 EDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANI 420
Query: 540 CRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKL 599
CRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKL
Sbjct: 421 CRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKL 480
Query: 600 AVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTA 659
AVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTA
Sbjct: 481 AVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTA 540
Query: 660 QISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 719
QISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR
Sbjct: 541 QISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 600
Query: 720 LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 779
LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS
Sbjct: 601 LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 660
Query: 780 AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE 839
AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE
Sbjct: 661 AQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLE 720
Query: 840 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 899
QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG
Sbjct: 721 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 780
Query: 900 PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLS 959
PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLS
Sbjct: 781 PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLS 840
Query: 960 IPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFE 1019
IPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFE
Sbjct: 841 IPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFE 900
Query: 1020 EIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEI 1079
EIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEI
Sbjct: 901 EIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEI 960
Query: 1080 LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1139
LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ
Sbjct: 961 LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1020
Query: 1140 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1199
QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA
Sbjct: 1021 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1080
Query: 1200 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEE 1259
KEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEE
Sbjct: 1081 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEE 1140
Query: 1260 VWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQI 1319
VWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQI
Sbjct: 1141 VWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQI 1200
Query: 1320 RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ 1379
RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ
Sbjct: 1201 RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ 1260
Query: 1380 ESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQ 1439
ESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQ
Sbjct: 1261 ESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQ 1320
Query: 1440 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1499
IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN
Sbjct: 1321 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1380
Query: 1500 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1559
HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK
Sbjct: 1381 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1440
Query: 1560 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1619
QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK
Sbjct: 1441 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1500
Query: 1620 QKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 1679
QKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET
Sbjct: 1501 QKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 1560
Query: 1680 FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 1739
FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA
Sbjct: 1561 FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 1620
Query: 1740 NRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQ 1799
NRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQ
Sbjct: 1621 NRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQ 1680
Query: 1800 GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKD 1859
GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKD
Sbjct: 1681 GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKD 1740
Query: 1860 LRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK 1919
LRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK
Sbjct: 1741 LRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK 1800
Query: 1920 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 1979
EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM
Sbjct: 1801 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 1860
Query: 1980 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKD 2039
VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKD
Sbjct: 1861 VMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKD 1920
Query: 2040 SLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSV 2099
SLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSV
Sbjct: 1921 SLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSV 1980
Query: 2100 EKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLN 2159
EKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLN
Sbjct: 1981 EKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLN 2040
Query: 2160 ATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEF 2219
ATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEF
Sbjct: 2041 ATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEF 2100
Query: 2220 VLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI 2279
VLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI
Sbjct: 2101 VLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI 2160
Query: 2280 SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLW 2339
SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLW
Sbjct: 2161 SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLW 2220
Query: 2340 LSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKL 2399
LSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKL
Sbjct: 2221 LSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKL 2280
Query: 2400 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2459
EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS
Sbjct: 2281 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2340
Query: 2460 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2519
SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR
Sbjct: 2341 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2400
Query: 2520 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2579
RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST
Sbjct: 2401 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2460
Query: 2580 QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL 2639
QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL
Sbjct: 2461 QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDL 2520
Query: 2640 ALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLA 2699
ALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLA
Sbjct: 2521 ALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLA 2580
Query: 2700 WLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKIL 2759
WLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKIL
Sbjct: 2581 WLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKIL 2640
Query: 2760 RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQL 2819
RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQL
Sbjct: 2641 RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQL 2700
Query: 2820 KDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEK 2879
KDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEK
Sbjct: 2701 KDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEK 2760
Query: 2880 LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT 2939
LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT
Sbjct: 2761 LYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEAT 2820
Query: 2940 DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT 2999
DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT
Sbjct: 2821 DELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLT 2880
Query: 3000 TLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWER 3059
TLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWER
Sbjct: 2881 TLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWER 2940
Query: 3060 AISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDL 3119
AISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDL
Sbjct: 2941 AISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDL 3000
Query: 3120 LSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLL 3179
LSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLL
Sbjct: 3001 LSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLL 3060
Query: 3180 NVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQ 3239
NVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQ
Sbjct: 3061 NVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQ 3120
Query: 3240 IPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAA 3299
IPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAA
Sbjct: 3121 IPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAA 3180
Query: 3300 AETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPT 3359
AETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPT
Sbjct: 3181 AETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPT 3240
Query: 3360 TSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPA 3419
TSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPA
Sbjct: 3241 TSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPA 3300
Query: 3420 SSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDS 3479
SSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDS
Sbjct: 3301 SSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDS 3360
Query: 3480 PLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPP 3539
PLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPP
Sbjct: 3361 PLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPP 3420
Query: 3540 EMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAE 3599
EMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAE
Sbjct: 3421 EMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAE 3480
Query: 3600 AKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQL 3659
AKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQL
Sbjct: 3481 AKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQL 3540
Query: 3660 NNSFPSSRGRNTPGKPMREDTM 3681
NNSFPSSRGRNTPGKPMREDTM
Sbjct: 3541 NNSFPSSRGRNTPGKPMREDTM 3562
>gi|5032291 dystrophin Dp260-2 isoform [Homo sapiens]
Length = 2341
Score = 4598 bits (11927), Expect = 0.0
Identities = 2328/2331 (99%), Positives = 2331/2331 (100%)
Query: 1351 HEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ 1410
+++AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ
Sbjct: 11 YKKAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQ 70
Query: 1411 SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 1470
SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES
Sbjct: 71 SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 130
Query: 1471 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1530
KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ
Sbjct: 131 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 190
Query: 1531 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL 1590
TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL
Sbjct: 191 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMEL 250
Query: 1591 TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS 1650
TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS
Sbjct: 251 TKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLS 310
Query: 1651 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE 1710
LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE
Sbjct: 311 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE 370
Query: 1711 DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG 1770
DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG
Sbjct: 371 DVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTG 430
Query: 1771 KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL 1830
KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL
Sbjct: 431 KASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNL 490
Query: 1831 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1890
QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD
Sbjct: 491 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 550
Query: 1891 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK 1950
DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK
Sbjct: 551 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSK 610
Query: 1951 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 2010
RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV
Sbjct: 611 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 670
Query: 2011 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 2070
EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL
Sbjct: 671 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 730
Query: 2071 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE 2130
QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE
Sbjct: 731 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE 790
Query: 2131 NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE 2190
NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE
Sbjct: 791 NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE 850
Query: 2191 VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK 2250
VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK
Sbjct: 851 VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVK 910
Query: 2251 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 2310
LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG
Sbjct: 911 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 970
Query: 2311 EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA 2370
EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA
Sbjct: 971 EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA 1030
Query: 2371 KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 2430
KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI
Sbjct: 1031 KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 1090
Query: 2431 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 2490
GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK
Sbjct: 1091 GASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIK 1150
Query: 2491 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 2550
SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI
Sbjct: 1151 SQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRI 1210
Query: 2551 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 2610
ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD
Sbjct: 1211 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 1270
Query: 2611 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 2670
AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH
Sbjct: 1271 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1330
Query: 2671 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 2730
KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL
Sbjct: 1331 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1390
Query: 2731 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 2790
MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL
Sbjct: 1391 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1450
Query: 2791 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 2850
NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE
Sbjct: 1451 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1510
Query: 2851 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2910
LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE
Sbjct: 1511 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1570
Query: 2911 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2970
WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH
Sbjct: 1571 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 1630
Query: 2971 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 3030
LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR
Sbjct: 1631 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 1690
Query: 3031 VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS 3090
VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS
Sbjct: 1691 VRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQS 1750
Query: 3091 LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL 3150
LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL
Sbjct: 1751 LADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCL 1810
Query: 3151 TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK 3210
TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK
Sbjct: 1811 TTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDK 1870
Query: 3211 YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP 3270
YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP
Sbjct: 1871 YRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKP 1930
Query: 3271 EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY 3330
EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY
Sbjct: 1931 EIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNY 1990
Query: 3331 DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY 3390
DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY
Sbjct: 1991 DICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGY 2050
Query: 3391 LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY 3450
LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY
Sbjct: 2051 LPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSY 2110
Query: 3451 LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE 3510
LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE
Sbjct: 2111 LNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLE 2170
Query: 3511 EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA 3570
EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA
Sbjct: 2171 EENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEA 2230
Query: 3571 RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS 3630
RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS
Sbjct: 2231 RMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGS 2290
Query: 3631 QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 3681
QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 2291 QTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 2341
Score = 209 bits (531), Expect = 5e-53
Identities = 384/1926 (19%), Positives = 785/1926 (40%), Gaps = 263/1926 (13%)
Query: 915 KQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQS-----ETKLSIPQLSV--TD 967
++V S + +K+LQ D R + + +Q+S E K+ +P L +
Sbjct: 94 QRVLSQIDVAQKKLQ---DVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVE 150
Query: 968 YEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 1027
E+++ +L L SL E +S + + T +++ +K +E ++ ++ + +
Sbjct: 151 QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNE 210
Query: 1028 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 1087
L +++ E Q+LE+ + RK++ + L +W+A D+ L + G L ++
Sbjct: 211 LGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG 270
Query: 1088 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1147
+ +I+ + L S+ E G+ +K + + +E +L LN+ W + +
Sbjct: 271 KATQKEIEKQKVHLKSITEVGEALKTVLGKK-ETLVEDKLSLLNSNWIAVTSRAEEWLNL 329
Query: 1148 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1207
L + + +++ + +W+ QA+ L + E K P Q+ + +KR K E
Sbjct: 330 LLEYQKHMETFDQNVDHITKWIIQADT--LLDESEKKKP---QQKEDVLKRLKAELNDIR 384
Query: 1208 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRL-NGKC----KTLEEVWA 1262
KV + +++A ++ ++ ++ L + + R+ GK K LE+ +
Sbjct: 385 PKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNS 444
Query: 1263 CWHELLSYLE---KANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQI 1319
+LL LE + L E +F E+ G +E+ + D+L+ + E +I
Sbjct: 445 DIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRIT-DERKREEI 503
Query: 1320 RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ 1379
+I Q L+T ++ ++L + RR+K LE S Q Q ++ L+
Sbjct: 504 KIKQQL--------------LQTKHNALKDLRSQ--RRKKALEISHQWYQYKRQADDLL- 546
Query: 1380 ESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTS-------------------HEI 1418
+ L I+K+LA+ D+ ++ +E QK + +L + +I
Sbjct: 547 KCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQI 606
Query: 1419 SLEEMKKHNQGKEAAQRVL--SQIDVAQKKLQDV---SMKFRLFQKPANFEQRLQESKMI 1473
L + + + K A R L +QI +++ V M + P+ + +
Sbjct: 607 QLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQA 666
Query: 1474 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1533
L EV+ L A + + + E + Q N+ SL + ++++ +Q
Sbjct: 667 LLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVE 726
Query: 1534 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1593
+L E ++ L + ++ +R+ + ++ ++ R+ ++ + +WL + L K
Sbjct: 727 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT 786
Query: 1594 SAVEGMPSNLD-SEVAWG-KATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDKLS 1650
+P N + ++ W K Q I +++ ++++ GE + K + +++++KL
Sbjct: 787 Q----IPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLG 842
Query: 1651 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTL----LDESEKKKP 1706
LN W V + + L E + + F ++++ W+ +AD + L+ ++++
Sbjct: 843 SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL 902
Query: 1707 QQKEDVLKRLKAEL---NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAI 1763
++K + +K L EL I +++ T + A + +E ++ + N ++ +
Sbjct: 903 KEKLEQVKLLVEELPLRQGILKQLNETGGPVL-VSAPISPEEQDKLENKLKQTNLQWIKV 961
Query: 1764 SHRI--KTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFN--KDMNEDNEGT 1819
S + K G+ +K+L Q ++K LE LE ++ + N + N+ N+
Sbjct: 962 SRALPEKQGEIEAQIKDLGQ----LEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEG 1017
Query: 1820 VKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYK 1879
++ + +Q + D EEI K Q L + A + + ++K ++S +W
Sbjct: 1018 PFDVQETEIAVQAKQPDV---EEILSKGQHLYKEKPATQPV----KRKLEDLSSEW---- 1066
Query: 1880 RQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAM 1939
+ + + +EL+ K+ +L A GL+ GA+
Sbjct: 1067 --------------------------KAVNRLLQELRAKQPDL------APGLTTIGAS- 1093
Query: 1940 AVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTE 1999
PTQ TV T V+T++ + +PS+ + E
Sbjct: 1094 ---PTQ--------------------------TVTLVTQPVVTKETAISKLEMPSSLMLE 1124
Query: 2000 I----------THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRI- 2048
+ T ++ L ++Q++ + + D ED+ + K L+Q ++
Sbjct: 1125 VPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLE 1184
Query: 2049 DIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYD 2108
++I + + +++ R + + + ++ QW++V + ++R+ + +
Sbjct: 1185 ELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM---------- 1234
Query: 2109 IKIFNQWL---TEAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTVVR 2156
+K QWL EAEQ L + + E+W+ Y K+L + Q QT V
Sbjct: 1235 LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVD 1294
Query: 2157 TLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDL 2216
N ++++ S D + ++N W+ + K++S+R+ LEE +L +F DL
Sbjct: 1295 VANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDL 1354
Query: 2217 NEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNET 2269
+F+ WL EA+ A++ + ++++L E + VK L+++ QG + L+E
Sbjct: 1355 EKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDEN 1414
Query: 2270 GGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDL 2329
+L S S ++ L+ +L N +W ++ + + +EA +L L++
Sbjct: 1415 SQKILRSLEGS-DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE- 1472
Query: 2330 EEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEK 2389
LL+WL E+ Q G F AVQ KQ DV + L ++
Sbjct: 1473 ------LLVWLQ--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKE 1515
Query: 2390 PATQPVKRKLEDLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQPVV 2446
P + +E + + +L QE R P+ Q VT L+ +
Sbjct: 1516 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQAE 1565
Query: 2447 TKETAISKLEMPSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL--E 2500
T KL + S+ ++ + + E TD L L +VIK VGDL +
Sbjct: 1566 EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 1625
Query: 2501 DINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEV 2560
+ + + K KA ++ + + + A+ L + T +E + +W +
Sbjct: 1626 SLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWKLL 1683
Query: 2561 QEHLQNRRQQLNEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQKK 2615
Q +++R +QL+E +D S +L + + K+ + T K
Sbjct: 1684 QVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPK 1743
Query: 2616 ITETKQLAKDLRQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-ASW 2666
+TE Q DL + + + L L LL +A D H + +N
Sbjct: 1744 MTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDI 1803
Query: 2667 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG 2726
I ++ LE+ H L PL ++ L WL T T + R+L G
Sbjct: 1804 LQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFKTG 1858
Query: 2727 VKELMK 2732
+ L K
Sbjct: 1859 IISLCK 1864
Score = 181 bits (460), Expect = 9e-45
Identities = 319/1726 (18%), Positives = 700/1726 (40%), Gaps = 236/1726 (13%)
Query: 755 LKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQL 814
+ +KV+A + ++ +K+Q S + +E+M ++ ++ Q++ + Q
Sbjct: 53 IADKVDAAQMP--QEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL-QD 109
Query: 815 LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 874
+S + + N F +LQ+ + + + L T E ++SQL C +
Sbjct: 110 VSMKFRLFQKPAN---FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 166
Query: 875 RLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIF 932
LS ++ ++E + + I K++ + P LD A H+ ++ + V R+++L+
Sbjct: 167 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 226
Query: 933 DTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGL 992
MR + M+ + W+ ++ +L+ ++ + +A Q +++Q+ L
Sbjct: 227 KLSRKMR--KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 284
Query: 993 YYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNH 1052
+ T V E K + + + + W ++S+ E L E + +
Sbjct: 285 KSI-TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 343
Query: 1053 IQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQ--CRLLVSDIQTIQPSLNSVNEGGQK 1110
+ + KW+ + D L E SE K Q K+ + L +++ I+P ++S +
Sbjct: 344 VDHITKWIIQADTLLDE-------SEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN 396
Query: 1111 IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALK-GGLEKTVSLQKDLSEMHEWM 1169
+ +E ++ ELN ++ + ++ K ++ LE+ S + L E E
Sbjct: 397 LMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE 456
Query: 1170 TQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1229
Q E DF ++ + V+E+ + + QQ+ + +
Sbjct: 457 IQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDER----------------KR 500
Query: 1230 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTE 1289
E +K + + L T + L + + K E+ W++ + K L+++E KL +
Sbjct: 501 EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 560
Query: 1290 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1349
P +I E+ + ++ ++ N +R A+ L++ G + +++ + RWRE
Sbjct: 561 E-PRDERKIKEI----DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-LSKRWRE 614
Query: 1350 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI 1409
+ + + ++L I + +E E + + ++ I + Y+ + +Q E +++
Sbjct: 615 IESKFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 673
Query: 1410 QS----------DLTSHEISLEEMKKHNQ----------GKEAA-------------QRV 1436
+ DL E SL+ +K Q K+ A Q
Sbjct: 674 LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 733
Query: 1437 LSQIDVAQKKL----QDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 1491
LSQ+D +K+ +D +F R +K F ++ L E + L +T+ E
Sbjct: 734 LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFL--RKTQIPEN 791
Query: 1492 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 1551
+ L + + ++ V + TG +I+Q+ + L E++ +L L + E+
Sbjct: 792 WEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEV 851
Query: 1552 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGK 1611
++++RK++LE+ + + ++++N WL D + G L ++ K
Sbjct: 852 CKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVK 910
Query: 1612 ATQKEIEKQKVHLKSITEVGEAL---KTVLGKKETLVEDKLSLLNSNWIAVT-------S 1661
+E+ ++ LK + E G + + +++ +E+KL N WI V+
Sbjct: 911 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 970
Query: 1662 RAEEWLNLLLEYQKHMETFDQNVDHITKWI---------------------------IQA 1694
E + L + +K +E ++ ++H+ W+ +QA
Sbjct: 971 EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA 1030
Query: 1695 -----DTLLDESE---KKKP------QQKEDVLKRLKAE---LNDIRPKVDSTRDQAANL 1737
+ +L + + K+KP ++ ED+ KA L ++R K +
Sbjct: 1031 KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 1090
Query: 1738 MANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFN---SDIQKLLEPLE 1794
A+ + +P ++ + AIS + + L FN +++ L L+
Sbjct: 1091 GASPTQTVTLVTQPVVT----KETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD 1146
Query: 1795 AEIQ---------QGVN---LKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREE 1842
I+ + +N +K++ +D+ E ++EL+ NL+ + +++ R
Sbjct: 1147 QVIKSQRVMVGDLEDINEMIIKQKATMQDL-EQRRPQLEELITAAQNLKNKTSNQEARTI 1205
Query: 1843 IKIKQQLLQTKHNALKDLRSQRRKKALEI---SHQWYQYKRQADDLL------------- 1886
I + + +Q + + +++ RR++ E+ S QW + K +A+ +L
Sbjct: 1206 ITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEG 1265
Query: 1887 -KCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAA---MAVE 1942
+D I+KK+ + K++ ++L++ + ++ A L D +A V
Sbjct: 1266 PYTVDAIQKKIT---------ETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVH 1316
Query: 1943 PTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTE--- 1999
++ WR I + ++ R + H + + PL++ +LTE
Sbjct: 1317 MITENINASWRSIHKRVSE-REAALEETHR--------LLQQFPLDLEKF-LAWLTEAET 1366
Query: 2000 ITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAAL 2059
+V Q E+LL +K ++L KQ + L+ ++ +D K +L
Sbjct: 1367 TANVLQDATRKERLLED----SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSL 1422
Query: 2060 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWL-TE 2118
+ + + V LQ L ++F+W ++ K + + + S ++W+R H ++ WL +
Sbjct: 1423 EGSD--DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLK 1480
Query: 2119 AEQFLRKTQI--------PENWEHAKYKWYLKELQDGIGQRQTVVRTLNATG-----EEI 2165
++ R+ I +N H +K LK + I VR E++
Sbjct: 1481 DDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKL 1540
Query: 2166 IQ--------QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLN 2217
Q + ++ +L+++ +N W+++ +D +++++E L E Q +
Sbjct: 1541 YQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD 1600
Query: 2218 EFVLWLEEADNIASI--PLEPGKEQQLKEKLEQVKLLVEEL-PLRQGILKQLNETGGPVL 2274
E L L +A+ I P+ L++ LE+VK L E+ PL++ + +
Sbjct: 1601 ELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 1660
Query: 2275 VSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLG 2320
+ +SP LE+ N +W + A+ ++ ++ +D G
Sbjct: 1661 LGIQLSPYNLSTLED----LNTRWKLLQVAVEDRVRQLHEAHRDFG 1702
Score = 130 bits (326), Expect = 3e-29
Identities = 219/1087 (20%), Positives = 429/1087 (39%), Gaps = 107/1087 (9%)
Query: 340 YQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLG 399
Y T + V LL E L A + D E + Q + + L GR+ I
Sbjct: 656 YLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS-- 713
Query: 400 SKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ--NQKLKELN 457
K + E ++QE ++ L+ +WE + ++Q R + + + +K N
Sbjct: 714 KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFN 773
Query: 458 DWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESS 517
WLT+ E+ RK + P+ + + K LQ+ + Q Q V +L + + S
Sbjct: 774 QWLTEAEQFLRKTQI----PENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 829
Query: 518 GDHATAALEEQLKVLGDRWANICRWTEDRWVLLQD---ILLKWQRLTEEQCLFSAWLSEK 574
+ L+E+L L RW +C+ DR L++ IL ++QR E F WL E+
Sbjct: 830 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNE---FVLWL-EE 885
Query: 575 EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQ 634
D + I K+Q LK LE+ K + +L L+Q +L L
Sbjct: 886 ADNIASIPLEPGKEQQ-----------LKEKLEQVKLLVEEL-PLRQGILKQLNETGGPV 933
Query: 635 KTEAWLDNFARCWDNLVQKLEKSTAQ---ISQAVTTTQPSLTQTTVMETVTTVTTREQIL 691
A + + D L KL+++ Q +S+A+ Q + + + +
Sbjct: 934 LVSAPISPEEQ--DKLENKLKQTNLQWIKVSRALPEKQGEI-EAQIKD------------ 978
Query: 692 VKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGN 751
+ +++L Q + S IR +L++ + +Q E A+ K+ +
Sbjct: 979 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEI----YNQPNQEGPFDVQETEIAVQAKQPD 1034
Query: 752 FSDLKEKVNAIEREKAEK---FRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRW 808
++ K + +EK RKL+D S +A+ + + + +
Sbjct: 1035 VEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 1094
Query: 809 IEFCQLLSE-------RLNWLEYQNNIIAFYNQLQQLEQMTTTAENWL-------KIQPT 854
+ L+++ ++ LE ++++ L + T +WL K Q
Sbjct: 1095 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 1154
Query: 855 TPSEPTAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFV-AFT 911
+ I + K + L +PQ+E L Q++ K Q + D +
Sbjct: 1155 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 1214
Query: 912 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 971
N + +V +Q R ++L + ++ E + Q+ KL + + +
Sbjct: 1215 NQWDEVQEHLQNRRQQLNEMLK--DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 1272
Query: 972 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQ 1031
++++ E + L L++ Q+ + + ++ + ++ +RK E I W+ + +
Sbjct: 1273 QKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKR 1332
Query: 1032 LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV--------DVFLKEEWPALGDSEILKKQ 1083
+ E LEE L++ ++ W+ E D KE L DS+ +K+
Sbjct: 1333 VSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER--LLEDSKGVKEL 1390
Query: 1084 LKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAE-PEFASRLETELKELNTQWDHMCQQVY 1142
+KQ + L +I+ ++++E QKI E + A L+ L +N +W + ++
Sbjct: 1391 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1450
Query: 1143 ARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEE 1202
+ L+ ++ L L E+ W+ ++E + +QK + + K E
Sbjct: 1451 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1510
Query: 1203 AQQKEAKVKLLTESVNSVIAQAPPVAQEALKKE---------LETLTTNYQWLCTRLNGK 1253
+ KE + E+V + + P E L +E + +T + +N +
Sbjct: 1511 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1570
Query: 1254 CKTLEEVWACWH----ELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVL-DSLENL 1308
+ L A W E L L++ + +E++ KL+ E I G + + ++L DSL++
Sbjct: 1571 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 1630
Query: 1309 MRH----------SEDNPNQIRILAQTLTDGGVMDELIN-EELETFNSRWRELHEEAVRR 1357
+ ++N + + LA+ LT G+ N LE N+RW+ L R
Sbjct: 1631 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 1690
Query: 1358 QKLLEQS 1364
+ L ++
Sbjct: 1691 VRQLHEA 1697
Score = 110 bits (276), Expect = 2e-23
Identities = 200/1036 (19%), Positives = 413/1036 (39%), Gaps = 155/1036 (14%)
Query: 649 NLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKR 708
N+ L++S+ +I + +L T +E V Q+ + + K R
Sbjct: 696 NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN----KMYKDR 751
Query: 709 QITVDSEIRK--RLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREK 766
Q D + K R DI + W+T +E L+ + N+ K K +E
Sbjct: 752 QGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP-----ENWEHAKYKWYL--KEL 804
Query: 767 AEKFRKLQDASRSAQALVEQMVNEGVNADS--IKQASEQLNSRWIEFCQLLSERLNWLEY 824
+ + Q R+ A E+++ + D+ +++ LN RW E C+ LS+R LE
Sbjct: 805 QDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEE 864
Query: 825 QNNIIA-FYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIK---SQLKICKDEVNRLSGLQ 880
Q NI++ F L + A+N I P P + +K Q+K+ +E+ G+
Sbjct: 865 QKNILSEFQRDLNEFVLWLEEADNIASI-PLEPGKEQQLKEKLEQVKLLVEELPLRQGIL 923
Query: 881 PQIER-----LKIQSIALKEKGQGPMFL---DADFVAFTNHFKQVFSDVQAREKELQTIF 932
Q+ L I+ +E+ + L + ++ + + +++A+ K+L +
Sbjct: 924 KQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLE 983
Query: 933 DTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGL 992
L + +E ++ + W+ +L I + ++ ++Q + ++Q +Q +
Sbjct: 984 KKLEDL--EEQLNHLLLWLSPIRNQLEIYN------QPNQEGPFDVQETEIAVQAKQPDV 1035
Query: 993 YYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVE------------------ 1034
+ + + + K+ P+ ++ + + E++ WK ++ L E
Sbjct: 1036 EEILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 1093
Query: 1035 -----------------HCQKLEEQMNKLRKIQ-----NHIQT-LKKWMAEVDVFLKEEW 1071
KLE + + ++ N T L W++ +D +K +
Sbjct: 1094 PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR 1153
Query: 1072 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE-LKEL 1130
+GD E + + + + + + D++ +P L + Q +KN+ + A + T+ ++ +
Sbjct: 1154 VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI 1213
Query: 1131 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1190
QWD + + + R++ L L+ + + E + + QA + T D +Q
Sbjct: 1214 QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ 1273
Query: 1191 KAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQW--LCT 1248
K + E K+ ++ +Q + V + + ++ A + K + T N W +
Sbjct: 1274 KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYS--ADDTRKVHMITENINASWRSIHK 1331
Query: 1249 RLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGA---EEISEVLDSL 1305
R++ + LEE + LEK WL E E TT N+ A E + E +
Sbjct: 1332 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVLQDATRKERLLEDSKGV 1387
Query: 1306 ENLMRHSED---------------NPNQIRILAQTLTDGGVMDELINEELETFNSRWREL 1350
+ LM+ +D + N +IL +G L+ L+ N +W EL
Sbjct: 1388 KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS--LEGSDDAVLLQRRLDNMNFKWSEL 1445
Query: 1351 HEEAVRRQKLLEQSIQSAQETEKSLHL-IQESLTFI---DKQLA--AYIADKVDAAQMPQ 1404
++++ + ++++ + K LHL +QE L ++ D +L+ A I A Q
Sbjct: 1446 RKKSLN----IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQN 1501
Query: 1405 EAQK------------IQSDLTSHEISLEEM------KKHNQGKE--AAQRVLSQIDVAQ 1444
+ + I S L + I L E K + + +E +R + + +
Sbjct: 1502 DVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR 1561
Query: 1445 KKLQDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVV--------- 1494
K+ ++V+ ++ +L A++++++ E+ L E++ L+ K + EV+
Sbjct: 1562 KQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD 1621
Query: 1495 ------QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHY 1548
Q L L ++ +K V V RQ+ +P L + L +
Sbjct: 1622 LLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTRW 1680
Query: 1549 NELGAKVTERKQQLEK 1564
L V +R +QL +
Sbjct: 1681 KLLQVAVEDRVRQLHE 1696
Score = 107 bits (266), Expect = 3e-22
Identities = 243/1327 (18%), Positives = 525/1327 (39%), Gaps = 212/1327 (15%)
Query: 412 EETEVQEQMNLLNSRWECLRVASMEKQSNL---HRVLMDLQNQKLKELNDWLTKTEERTR 468
+ET V+++++LLNS W + + E+ NL ++ M+ +Q + + W+ + +
Sbjct: 301 KETLVEDKLSLLNSNWIAV-TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 359
Query: 469 KMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ 528
+ E++ + LKR L+ +L + +V+S + + GDH +E Q
Sbjct: 360 ESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 412
Query: 529 LKVLGDRWANICR--WTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGF 586
+ L R+A I T + L+++ Q ++ Q L +E + VN
Sbjct: 413 ISELNHRFAAISHRIKTGKASIPLKEL---EQFNSDIQKLLEPLEAEIQQGVNLKEEDFN 469
Query: 587 KDQNEMLSSLQKLAVLKADL-------EKKKQSMGKLYSLKQDLLSTLKN---------- 629
KD NE K + + D E+K++ + +KQ LL T N
Sbjct: 470 KDMNEDNEGTVKELLQRGDNLQQRITDERKREEI----KIKQQLLQTKHNALKDLRSQRR 525
Query: 630 KSVTQKTEAW------LDNFARCWDNLVQKL--------EKSTAQISQAVTTTQPSLTQT 675
K + + W D+ +C D++ +KL E+ +I + + + L
Sbjct: 526 KKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAV 585
Query: 676 --------------TVMETVTTVTTR-EQILVKHAQ------EELPPPPPQKKRQITVD- 713
V T ++ R +I K AQ ++ + +T D
Sbjct: 586 RRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDM 645
Query: 714 ----SEIRKRLDVDITELHSWITRSEAVLQSPEFA------IFRKEGNFSDLKEKV---- 759
S + +IT + + E +L +P+ +F++E + ++K+ +
Sbjct: 646 PLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSS 705
Query: 760 NAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERL 819
I+ ++K LQ A+ V +++A QL+ +W + ++ +R
Sbjct: 706 GRIDIIHSKKTAALQSAT-------------PVERVKLQEALSQLDFQWEKVNKMYKDRQ 752
Query: 820 --------NWLEYQNNIIAFYNQLQQLEQM---TTTAENWLKIQPTTPSEPTAIKSQLKI 868
W + +I F L + EQ T ENW E K LK
Sbjct: 753 GRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW---------EHAKYKWYLKE 803
Query: 869 CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKEL 928
+D + + + + + I K + L + +++V + R+K L
Sbjct: 804 LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASI-LQEKLGSLNLRWQEVCKQLSDRKKRL 862
Query: 929 QTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQ 988
+ + L +Q ++ W+++++ SIP L + ++++L +++ L L +
Sbjct: 863 EEQKNIL--SEFQRDLNEFVLWLEEADNIASIP-LEPGKEQQLKEKLEQVKLLVEELPLR 919
Query: 989 QSGLYYLSTTVKEMSKKAP--SEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKL 1046
Q L L+ T + AP E K +++ ++ +W K+S L E ++E Q+ L
Sbjct: 920 QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDL 979
Query: 1047 RKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD----IQTIQPSLN 1102
+++ ++ L++ + + ++L P EI + ++ V + +Q QP +
Sbjct: 980 GQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 1036
Query: 1103 SVNEGGQKIKNEAEPEFASRLETELKELNTQW---DHMCQQVYARKEALKGGL------- 1152
+ GQ + E ++ +L++L+++W + + Q++ A++ L GL
Sbjct: 1037 EILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 1094
Query: 1153 EKTVSL-------------------------------QKDLSEMHEWMTQAEEEYLERDF 1181
+TV+L + +E+ +W++ ++ +
Sbjct: 1095 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 1154
Query: 1182 EYKTPDELQKAVEEMKRAKEEAQQKEAKV-KLLTESVNSVIAQAPPVAQEALKKELETLT 1240
+++ + + + K ++ +Q+ ++ +L+T + N + A+ + +E +
Sbjct: 1155 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 1214
Query: 1241 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1300
+ + L + + L E+ + L E+A + L + KL++ + P + I +
Sbjct: 1215 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 1274
Query: 1301 VLDSLENL---MRHSEDNPNQIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAV 1355
+ + L +R + N + LA L D+ ++ E N+ WR +H+
Sbjct: 1275 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 1334
Query: 1356 RRQKLLEQSIQSAQ----ETEKSLHLIQESLTFID-----KQLAAYIADKVDAAQMPQEA 1406
R+ LE++ + Q + EK L + E+ T + + + D ++ ++
Sbjct: 1335 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1394
Query: 1407 QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQ 1465
Q +Q ++ +H + +++Q + + Q++L +++ K+ L +K N
Sbjct: 1395 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1454
Query: 1466 RLQESK-------MILDEVKMHLPALETKSVEQEVVQSQ---LNHCVNLYKSLSEVKSEV 1515
L+ S + L E+ + L + + Q + + +++++
Sbjct: 1455 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1514
Query: 1516 EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 1575
E VI + + V+ TE P E E KL+ ER Q + + L RK +E
Sbjct: 1515 EPVIMSTLETVRIFLTEQPLEGLE-----KLYQEPRELPPEERAQNVTRLL---RKQAEE 1566
Query: 1576 MNVLTEW 1582
+N TEW
Sbjct: 1567 VN--TEW 1571
Score = 65.9 bits (159), Expect = 7e-10
Identities = 76/369 (20%), Positives = 140/369 (37%), Gaps = 28/369 (7%)
Query: 298 TQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDT 357
TQ + T LE P SSLM L + A E+ WL +
Sbjct: 1095 TQTVTLVTQPVVTKETAISKLEMP------SSLMLEVPALADFNRAWTELTDWLSLLDQV 1148
Query: 358 LQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQ 417
+++Q + D+E + + + M DL + ++ ++ L +T Q
Sbjct: 1149 IKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNL--------KNKTSNQ 1200
Query: 418 EQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTR-------KM 470
E ++ R E ++ E Q +L L N+ LK+ WL EE + K+
Sbjct: 1201 EARTIITDRIERIQNQWDEVQEHLQNRRQQL-NEMLKDSTQWLEAKEEAEQVLGQARAKL 1259
Query: 471 EEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQL 529
E GP ++ +++++ + K L +DL Q Q V+ + + + T +
Sbjct: 1260 ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMIT 1319
Query: 530 KVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFK-- 587
+ + W +I + +R L++ Q+ + F AWL+E E N + K
Sbjct: 1320 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1379
Query: 588 ---DQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 644
D + +++ L+ ++E L Q +L +L+ + LDN
Sbjct: 1380 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1439
Query: 645 RCWDNLVQK 653
W L +K
Sbjct: 1440 FKWSELRKK 1448
Score = 47.4 bits (111), Expect = 3e-04
Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)
Query: 259 EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 318
E H ++H + + Q + +G + + R + + + S RS HL
Sbjct: 1402 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 1456
Query: 319 EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 378
EA D+ R +L+E+L WL +D L Q I D V+ Q H
Sbjct: 1457 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 1504
Query: 379 EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 420
+ +L + + + L+ L G KL ++ EE +++Q
Sbjct: 1505 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 1564
Query: 421 NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 475
+N+ WE L + S + Q + L ++L+EL + + + + R+ E +P+
Sbjct: 1565 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 1619
Query: 476 GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 531
G L D L+ +++ K L+ + L++ VN L + + + + LE+
Sbjct: 1620 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 1675
Query: 532 LGDRWANICRWTEDR 546
L RW + EDR
Sbjct: 1676 LNTRWKLLQVAVEDR 1690
>gi|150036268 dystrophin Dp260-1 isoform [Homo sapiens]
Length = 2344
Score = 4597 bits (11923), Expect = 0.0
Identities = 2328/2328 (100%), Positives = 2328/2328 (100%)
Query: 1354 AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL 1413
AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL
Sbjct: 17 AVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDL 76
Query: 1414 TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1473
TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI
Sbjct: 77 TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 136
Query: 1474 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1533
LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN
Sbjct: 137 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 196
Query: 1534 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1593
PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR
Sbjct: 197 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 256
Query: 1594 SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLN 1653
SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLN
Sbjct: 257 SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLN 316
Query: 1654 SNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL 1713
SNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL
Sbjct: 317 SNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVL 376
Query: 1714 KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKAS 1773
KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKAS
Sbjct: 377 KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKAS 436
Query: 1774 IPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1833
IPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR
Sbjct: 437 IPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 496
Query: 1834 ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE 1893
ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE
Sbjct: 497 ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE 556
Query: 1894 KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWR 1953
KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWR
Sbjct: 557 KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWR 616
Query: 1954 EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 2013
EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL
Sbjct: 617 EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 676
Query: 2014 LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 2073
LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA
Sbjct: 677 LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 736
Query: 2074 LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWE 2133
LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWE
Sbjct: 737 LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWE 796
Query: 2134 HAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK 2193
HAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK
Sbjct: 797 HAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK 856
Query: 2194 QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV 2253
QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV
Sbjct: 857 QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV 916
Query: 2254 EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE 2313
EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE
Sbjct: 917 EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE 976
Query: 2314 AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP 2373
AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP
Sbjct: 977 AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP 1036
Query: 2374 DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 2433
DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS
Sbjct: 1037 DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 1096
Query: 2434 PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR 2493
PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR
Sbjct: 1097 PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR 1156
Query: 2494 VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI 2553
VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI
Sbjct: 1157 VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI 1216
Query: 2554 QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ 2613
QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ
Sbjct: 1217 QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ 1276
Query: 2614 KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV 2673
KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV
Sbjct: 1277 KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRV 1336
Query: 2674 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 2733
SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ
Sbjct: 1337 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 1396
Query: 2734 WQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIR 2793
WQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIR
Sbjct: 1397 WQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIR 1456
Query: 2794 SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 2853
SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT
Sbjct: 1457 SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 1516
Query: 2854 KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK 2913
KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK
Sbjct: 1517 KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK 1576
Query: 2914 LNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEK 2973
LNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEK
Sbjct: 1577 LNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEK 1636
Query: 2974 VKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 3033
VKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ
Sbjct: 1637 VKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 1696
Query: 3034 LHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLAD 3093
LHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLAD
Sbjct: 1697 LHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLAD 1756
Query: 3094 LNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTI 3153
LNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTI
Sbjct: 1757 LNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTI 1816
Query: 3154 YDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRY 3213
YDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRY
Sbjct: 1817 YDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRY 1876
Query: 3214 LFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIE 3273
LFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIE
Sbjct: 1877 LFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIE 1936
Query: 3274 AALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDIC 3333
AALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDIC
Sbjct: 1937 AALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDIC 1996
Query: 3334 QSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPV 3393
QSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPV
Sbjct: 1997 QSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPV 2056
Query: 3394 QTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLND 3453
QTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLND
Sbjct: 2057 QTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLND 2116
Query: 3454 SISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEEN 3513
SISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEEN
Sbjct: 2117 SISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEEN 2176
Query: 3514 RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 3573
RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ
Sbjct: 2177 RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 2236
Query: 3574 ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 3633
ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS
Sbjct: 2237 ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 2296
Query: 3634 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 3681
DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 2297 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 2344
Score = 181 bits (460), Expect = 9e-45
Identities = 319/1726 (18%), Positives = 700/1726 (40%), Gaps = 236/1726 (13%)
Query: 755 LKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQL 814
+ +KV+A + ++ +K+Q S + +E+M ++ ++ Q++ + Q
Sbjct: 56 IADKVDAAQMP--QEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL-QD 112
Query: 815 LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 874
+S + + N F +LQ+ + + + L T E ++SQL C +
Sbjct: 113 VSMKFRLFQKPAN---FEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 169
Query: 875 RLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIF 932
LS ++ ++E + + I K++ + P LD A H+ ++ + V R+++L+
Sbjct: 170 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 229
Query: 933 DTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGL 992
MR + M+ + W+ ++ +L+ ++ + +A Q +++Q+ L
Sbjct: 230 KLSRKMR--KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 287
Query: 993 YYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNH 1052
+ T V E K + + + + W ++S+ E L E + +
Sbjct: 288 KSI-TEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 346
Query: 1053 IQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQ--CRLLVSDIQTIQPSLNSVNEGGQK 1110
+ + KW+ + D L E SE K Q K+ + L +++ I+P ++S +
Sbjct: 347 VDHITKWIIQADTLLDE-------SEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAAN 399
Query: 1111 IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALK-GGLEKTVSLQKDLSEMHEWM 1169
+ +E ++ ELN ++ + ++ K ++ LE+ S + L E E
Sbjct: 400 LMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAE 459
Query: 1170 TQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1229
Q E DF ++ + V+E+ + + QQ+ + +
Sbjct: 460 IQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDER----------------KR 503
Query: 1230 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTE 1289
E +K + + L T + L + + K E+ W++ + K L+++E KL +
Sbjct: 504 EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 563
Query: 1290 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1349
P +I E+ + ++ ++ N +R A+ L++ G + +++ + RWRE
Sbjct: 564 E-PRDERKIKEI----DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-LSKRWRE 617
Query: 1350 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKI 1409
+ + + ++L I + +E E + + ++ I + Y+ + +Q E +++
Sbjct: 618 IESKFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 676
Query: 1410 QS----------DLTSHEISLEEMKKHNQ----------GKEAA-------------QRV 1436
+ DL E SL+ +K Q K+ A Q
Sbjct: 677 LNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEA 736
Query: 1437 LSQIDVAQKKL----QDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 1491
LSQ+D +K+ +D +F R +K F ++ L E + L +T+ E
Sbjct: 737 LSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFL--RKTQIPEN 794
Query: 1492 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 1551
+ L + + ++ V + TG +I+Q+ + L E++ +L L + E+
Sbjct: 795 WEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEV 854
Query: 1552 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGK 1611
++++RK++LE+ + + ++++N WL D + G L ++ K
Sbjct: 855 CKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVK 913
Query: 1612 ATQKEIEKQKVHLKSITEVGEAL---KTVLGKKETLVEDKLSLLNSNWIAVT-------S 1661
+E+ ++ LK + E G + + +++ +E+KL N WI V+
Sbjct: 914 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQG 973
Query: 1662 RAEEWLNLLLEYQKHMETFDQNVDHITKWI---------------------------IQA 1694
E + L + +K +E ++ ++H+ W+ +QA
Sbjct: 974 EIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA 1033
Query: 1695 -----DTLLDESE---KKKP------QQKEDVLKRLKAE---LNDIRPKVDSTRDQAANL 1737
+ +L + + K+KP ++ ED+ KA L ++R K +
Sbjct: 1034 KQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTI 1093
Query: 1738 MANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFN---SDIQKLLEPLE 1794
A+ + +P ++ + AIS + + L FN +++ L L+
Sbjct: 1094 GASPTQTVTLVTQPVVT----KETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLD 1149
Query: 1795 AEIQ---------QGVN---LKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREE 1842
I+ + +N +K++ +D+ E ++EL+ NL+ + +++ R
Sbjct: 1150 QVIKSQRVMVGDLEDINEMIIKQKATMQDL-EQRRPQLEELITAAQNLKNKTSNQEARTI 1208
Query: 1843 IKIKQQLLQTKHNALKDLRSQRRKKALEI---SHQWYQYKRQADDLL------------- 1886
I + + +Q + + +++ RR++ E+ S QW + K +A+ +L
Sbjct: 1209 ITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEG 1268
Query: 1887 -KCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAA---MAVE 1942
+D I+KK+ + K++ ++L++ + ++ A L D +A V
Sbjct: 1269 PYTVDAIQKKIT---------ETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVH 1319
Query: 1943 PTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTE--- 1999
++ WR I + ++ R + H + + PL++ +LTE
Sbjct: 1320 MITENINASWRSIHKRVSE-REAALEETHR--------LLQQFPLDLEKF-LAWLTEAET 1369
Query: 2000 ITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAAL 2059
+V Q E+LL +K ++L KQ + L+ ++ +D K +L
Sbjct: 1370 TANVLQDATRKERLLED----SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSL 1425
Query: 2060 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWL-TE 2118
+ + + V LQ L ++F+W ++ K + + + S ++W+R H ++ WL +
Sbjct: 1426 EGSD--DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLK 1483
Query: 2119 AEQFLRKTQI--------PENWEHAKYKWYLKELQDGIGQRQTVVRTLNATG-----EEI 2165
++ R+ I +N H +K LK + I VR E++
Sbjct: 1484 DDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKL 1543
Query: 2166 IQ--------QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLN 2217
Q + ++ +L+++ +N W+++ +D +++++E L E Q +
Sbjct: 1544 YQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD 1603
Query: 2218 EFVLWLEEADNIASI--PLEPGKEQQLKEKLEQVKLLVEEL-PLRQGILKQLNETGGPVL 2274
E L L +A+ I P+ L++ LE+VK L E+ PL++ + +
Sbjct: 1604 ELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 1663
Query: 2275 VSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLG 2320
+ +SP LE+ N +W + A+ ++ ++ +D G
Sbjct: 1664 LGIQLSPYNLSTLED----LNTRWKLLQVAVEDRVRQLHEAHRDFG 1705
Score = 178 bits (452), Expect = 8e-44
Identities = 385/1950 (19%), Positives = 769/1950 (39%), Gaps = 249/1950 (12%)
Query: 935 LPPMRYQETMSAIRTWVQQSETKLSIPQLSVT--DYEIMEQRLGELQALQSSLQEQ--QS 990
L +R Q+ + Q++E L + Q S+T D ++ ++ A Q + Q QS
Sbjct: 15 LNAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQS 74
Query: 991 GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQ 1050
L +++EM K ++ Q +I+ KKL ++ K +
Sbjct: 75 DLTSHEISLEEMKKH--NQGKEAAQRVLSQIDVAQKKLQDVSMKF-----RLFQKPANFE 127
Query: 1051 NHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQK 1110
+Q K + EV + L + E+++ QL C L + ++ + V + G++
Sbjct: 128 QRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQ 187
Query: 1111 IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMT 1170
I + + E L+ + L ++ + +V RK+ L+ L+ + ++K+++ + EW+
Sbjct: 188 IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 247
Query: 1171 QAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQE 1230
+ E +R P L V K ++E ++++ +K +TE E
Sbjct: 248 ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE------------VGE 295
Query: 1231 ALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTEN 1290
ALK L T + K L W ++ +A +WLN + K E
Sbjct: 296 ALKTVLGKKE-------TLVEDKLSLLNSNW------IAVTSRAEEWLNLLLEYQKHMET 342
Query: 1291 IPGGAEEISEVLDSLENLMRHSE-DNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1349
+ I++ + + L+ SE P Q + + L ++++ + T +
Sbjct: 343 FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLK--AELNDIRPKVDSTRDQAANL 400
Query: 1350 LHEEAVRRQKLLEQSIQSAQETEKSL-HLIQESLTFID-KQLAAYIADKVDAAQMPQEAQ 1407
+ +KL+E I ++ H I+ I K+L + +D + P EA+
Sbjct: 401 MANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSD-IQKLLEPLEAE 459
Query: 1408 KIQSDLTSHEISLEEMKKHNQG--KEAAQR--VLSQIDVAQKKLQDVSMKFRLFQKPANF 1463
Q E ++M + N+G KE QR L Q ++K +++ +K +L Q N
Sbjct: 460 IQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNA 519
Query: 1464 --EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKT 1521
+ R Q K L+ + + K ++++ L+ SL E + E + +
Sbjct: 520 LKDLRSQRRKKALE---ISHQWYQYKRQADDLLKC-LDDIEKKLASLPEPRDE-RKIKEI 574
Query: 1522 GRQIVQKKQTEN-----PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKM---- 1572
R++ +KK+ N + L E A+ + ++ ++++R +++E R++
Sbjct: 575 DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQI--QLSKRWREIESKFAQFRRLNFAQ 632
Query: 1573 -----RKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIE--------- 1618
+ M V+TE DM L + +PS +E+ E+E
Sbjct: 633 IHTVREETMMVMTE-----DMPL----EISYVPSTYLTEITHVSQALLEVEQLLNAPDLC 683
Query: 1619 --------KQKVHLKSI---------------TEVGEALKTVLGKKETLVEDKLSLLNSN 1655
KQ+ LK+I ++ AL++ + +++ LS L+
Sbjct: 684 AKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQ 743
Query: 1656 WIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDES---EKKKPQQKEDV 1712
W V ++ + F ++ +W+ +A+ L ++ E + + +
Sbjct: 744 WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 803
Query: 1713 LKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKA 1772
LK L+ + + V + ++ +++ ++ LN R+ + ++ K
Sbjct: 804 LKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKK 863
Query: 1773 SIPLKE--LEQFNSDIQKLL-----------EPLEAEIQQGVNLKEEDFNKDMNE--DNE 1817
+ ++ L +F D+ + + PLE +Q + K E + E +
Sbjct: 864 RLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQ 923
Query: 1818 GTVKELLQRGDNLQQRI---TDERKREEIKIKQQLLQ--TKHNALKDLRSQ---RRKKAL 1869
G +K+L + G + +E+ + E K+KQ LQ AL + + + + K
Sbjct: 924 GILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLG 983
Query: 1870 EISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER--KIKEIDRELQKKKEELNAVRR 1927
++ + + Q + LL L I +L +P E ++E + +Q K+ ++ +
Sbjct: 984 QLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILS 1043
Query: 1928 QAEGL-SEDGAAMAVEPTQIQLSKRWREIESKFAQFR-----------RLNFAQIHTVRE 1975
+ + L E A V+ LS W+ + + R + + TV
Sbjct: 1044 KGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTL 1103
Query: 1976 ETMMVMTEDMPLEISYVPSTYLTEI----------THVSQALLEVEQLLNAPDLCAKDFE 2025
T V+T++ + +PS+ + E+ T ++ L ++Q++ + + D E
Sbjct: 1104 VTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLE 1163
Query: 2026 DLFKQEESLKNIKDSLQQSSGRI-DIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKV 2084
D+ + K L+Q ++ ++I + + +++ R + + + ++ QW++V
Sbjct: 1164 DINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEV 1223
Query: 2085 NKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWL---TEAEQFLRKTQIP-ENWEHAKYK-- 2138
+ ++R+ + + +K QWL EAEQ L + + E+W+ Y
Sbjct: 1224 QEHLQNRRQQLNEM----------LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 1273
Query: 2139 ------WYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC 2192
K+L + Q QT V N ++++ S D + ++N W+ +
Sbjct: 1274 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 1333
Query: 2193 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLL 2252
K++S+R+ LEE +L +F DL +F+ WL EA+ A++ + ++++L E + VK L
Sbjct: 1334 KRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKEL 1393
Query: 2253 VEELPLRQG-------ILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRAL 2305
+++ QG + L+E +L S S ++ L+ +L N +W ++ +
Sbjct: 1394 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS-DDAVLLQRRLDNMNFKWSELRKKS 1452
Query: 2306 PEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETE 2365
+ +EA +L L++ LL+WL E+ Q G F
Sbjct: 1453 LNIRSHLEASSDQWKRLHLSLQE-------LLVWLQ--LKDDELSRQAPIGGDFP----- 1498
Query: 2366 IAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSE--WKAVNRLLQELRAKQPDL 2423
AVQ KQ DV + L ++P + +E + + +L QE R P+
Sbjct: 1499 -AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE- 1553
Query: 2424 APGLTTIGASPTQTVT-LVTQPVVTKETAISKLEMPSS-LMLEVPALADFNRAWTELTDW 2481
Q VT L+ + T KL + S+ ++ + + E TD
Sbjct: 1554 ---------ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDE 1604
Query: 2482 LSL---LDQVIKSQRVMVGDL--EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNK 2536
L L +VIK VGDL + + + + K KA ++ + + + A+ L
Sbjct: 1605 LDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTL 1664
Query: 2537 TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKD----STQWLEAKEEAEQVL 2592
+ T +E + +W +Q +++R +QL+E +D S +L +
Sbjct: 1665 GIQLSPYNLST--LEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWER 1722
Query: 2593 GQARAKLESW-KEGPYTVDAIQKKITETKQLAKDLRQWQTNV--------DVANDLALKL 2643
+ K+ + T K+TE Q DL + + + L L L
Sbjct: 1723 AISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDL 1782
Query: 2644 LRDYSADDTRKVHMITENIN-ASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT 2702
L +A D H + +N I ++ LE+ H L PL ++ L WL
Sbjct: 1783 LSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLL 1842
Query: 2703 EAETTANVLQDATRKERLLEDSKGVKELMK 2732
T T + R+L G+ L K
Sbjct: 1843 NVYDTGR-----TGRIRVLSFKTGIISLCK 1867
Score = 130 bits (326), Expect = 3e-29
Identities = 219/1087 (20%), Positives = 429/1087 (39%), Gaps = 107/1087 (9%)
Query: 340 YQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLG 399
Y T + V LL E L A + D E + Q + + L GR+ I
Sbjct: 659 YLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS-- 716
Query: 400 SKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ--NQKLKELN 457
K + E ++QE ++ L+ +WE + ++Q R + + + +K N
Sbjct: 717 KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFN 776
Query: 458 DWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESS 517
WLT+ E+ RK + P+ + + K LQ+ + Q Q V +L + + S
Sbjct: 777 QWLTEAEQFLRKTQI----PENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 832
Query: 518 GDHATAALEEQLKVLGDRWANICRWTEDRWVLLQD---ILLKWQRLTEEQCLFSAWLSEK 574
+ L+E+L L RW +C+ DR L++ IL ++QR E F WL E+
Sbjct: 833 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNE---FVLWL-EE 888
Query: 575 EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQ 634
D + I K+Q LK LE+ K + +L L+Q +L L
Sbjct: 889 ADNIASIPLEPGKEQQ-----------LKEKLEQVKLLVEEL-PLRQGILKQLNETGGPV 936
Query: 635 KTEAWLDNFARCWDNLVQKLEKSTAQ---ISQAVTTTQPSLTQTTVMETVTTVTTREQIL 691
A + + D L KL+++ Q +S+A+ Q + + + +
Sbjct: 937 LVSAPISPEEQ--DKLENKLKQTNLQWIKVSRALPEKQGEI-EAQIKD------------ 981
Query: 692 VKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGN 751
+ +++L Q + S IR +L++ + +Q E A+ K+ +
Sbjct: 982 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEI----YNQPNQEGPFDVQETEIAVQAKQPD 1037
Query: 752 FSDLKEKVNAIEREKAEK---FRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRW 808
++ K + +EK RKL+D S +A+ + + + +
Sbjct: 1038 VEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 1097
Query: 809 IEFCQLLSE-------RLNWLEYQNNIIAFYNQLQQLEQMTTTAENWL-------KIQPT 854
+ L+++ ++ LE ++++ L + T +WL K Q
Sbjct: 1098 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 1157
Query: 855 TPSEPTAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFV-AFT 911
+ I + K + L +PQ+E L Q++ K Q + D +
Sbjct: 1158 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 1217
Query: 912 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 971
N + +V +Q R ++L + ++ E + Q+ KL + + +
Sbjct: 1218 NQWDEVQEHLQNRRQQLNEMLK--DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAI 1275
Query: 972 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQ 1031
++++ E + L L++ Q+ + + ++ + ++ +RK E I W+ + +
Sbjct: 1276 QKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKR 1335
Query: 1032 LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV--------DVFLKEEWPALGDSEILKKQ 1083
+ E LEE L++ ++ W+ E D KE L DS+ +K+
Sbjct: 1336 VSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER--LLEDSKGVKEL 1393
Query: 1084 LKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAE-PEFASRLETELKELNTQWDHMCQQVY 1142
+KQ + L +I+ ++++E QKI E + A L+ L +N +W + ++
Sbjct: 1394 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 1453
Query: 1143 ARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEE 1202
+ L+ ++ L L E+ W+ ++E + +QK + + K E
Sbjct: 1454 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 1513
Query: 1203 AQQKEAKVKLLTESVNSVIAQAPPVAQEALKKE---------LETLTTNYQWLCTRLNGK 1253
+ KE + E+V + + P E L +E + +T + +N +
Sbjct: 1514 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 1573
Query: 1254 CKTLEEVWACWH----ELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVL-DSLENL 1308
+ L A W E L L++ + +E++ KL+ E I G + + ++L DSL++
Sbjct: 1574 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 1633
Query: 1309 MRH----------SEDNPNQIRILAQTLTDGGVMDELIN-EELETFNSRWRELHEEAVRR 1357
+ ++N + + LA+ LT G+ N LE N+RW+ L R
Sbjct: 1634 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDR 1693
Query: 1358 QKLLEQS 1364
+ L ++
Sbjct: 1694 VRQLHEA 1700
Score = 110 bits (276), Expect = 2e-23
Identities = 200/1036 (19%), Positives = 413/1036 (39%), Gaps = 155/1036 (14%)
Query: 649 NLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKR 708
N+ L++S+ +I + +L T +E V Q+ + + K R
Sbjct: 699 NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN----KMYKDR 754
Query: 709 QITVDSEIRK--RLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREK 766
Q D + K R DI + W+T +E L+ + N+ K K +E
Sbjct: 755 QGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIP-----ENWEHAKYKWYL--KEL 807
Query: 767 AEKFRKLQDASRSAQALVEQMVNEGVNADS--IKQASEQLNSRWIEFCQLLSERLNWLEY 824
+ + Q R+ A E+++ + D+ +++ LN RW E C+ LS+R LE
Sbjct: 808 QDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEE 867
Query: 825 QNNIIA-FYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIK---SQLKICKDEVNRLSGLQ 880
Q NI++ F L + A+N I P P + +K Q+K+ +E+ G+
Sbjct: 868 QKNILSEFQRDLNEFVLWLEEADNIASI-PLEPGKEQQLKEKLEQVKLLVEELPLRQGIL 926
Query: 881 PQIER-----LKIQSIALKEKGQGPMFL---DADFVAFTNHFKQVFSDVQAREKELQTIF 932
Q+ L I+ +E+ + L + ++ + + +++A+ K+L +
Sbjct: 927 KQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLE 986
Query: 933 DTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGL 992
L + +E ++ + W+ +L I + ++ ++Q + ++Q +Q +
Sbjct: 987 KKLEDL--EEQLNHLLLWLSPIRNQLEIYN------QPNQEGPFDVQETEIAVQAKQPDV 1038
Query: 993 YYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVE------------------ 1034
+ + + + K+ P+ ++ + + E++ WK ++ L E
Sbjct: 1039 EEILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 1096
Query: 1035 -----------------HCQKLEEQMNKLRKIQ-----NHIQT-LKKWMAEVDVFLKEEW 1071
KLE + + ++ N T L W++ +D +K +
Sbjct: 1097 PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR 1156
Query: 1072 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE-LKEL 1130
+GD E + + + + + + D++ +P L + Q +KN+ + A + T+ ++ +
Sbjct: 1157 VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI 1216
Query: 1131 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1190
QWD + + + R++ L L+ + + E + + QA + T D +Q
Sbjct: 1217 QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ 1276
Query: 1191 KAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQW--LCT 1248
K + E K+ ++ +Q + V + + ++ A + K + T N W +
Sbjct: 1277 KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYS--ADDTRKVHMITENINASWRSIHK 1334
Query: 1249 RLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGA---EEISEVLDSL 1305
R++ + LEE + LEK WL E E TT N+ A E + E +
Sbjct: 1335 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVLQDATRKERLLEDSKGV 1390
Query: 1306 ENLMRHSED---------------NPNQIRILAQTLTDGGVMDELINEELETFNSRWREL 1350
+ LM+ +D + N +IL +G L+ L+ N +W EL
Sbjct: 1391 KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS--LEGSDDAVLLQRRLDNMNFKWSEL 1448
Query: 1351 HEEAVRRQKLLEQSIQSAQETEKSLHL-IQESLTFI---DKQLA--AYIADKVDAAQMPQ 1404
++++ + ++++ + K LHL +QE L ++ D +L+ A I A Q
Sbjct: 1449 RKKSLN----IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQN 1504
Query: 1405 EAQK------------IQSDLTSHEISLEEM------KKHNQGKE--AAQRVLSQIDVAQ 1444
+ + I S L + I L E K + + +E +R + + +
Sbjct: 1505 DVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR 1564
Query: 1445 KKLQDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVV--------- 1494
K+ ++V+ ++ +L A++++++ E+ L E++ L+ K + EV+
Sbjct: 1565 KQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD 1624
Query: 1495 ------QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHY 1548
Q L L ++ +K V V RQ+ +P L + L +
Sbjct: 1625 LLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNL-STLEDLNTRW 1683
Query: 1549 NELGAKVTERKQQLEK 1564
L V +R +QL +
Sbjct: 1684 KLLQVAVEDRVRQLHE 1699
Score = 107 bits (266), Expect = 3e-22
Identities = 243/1327 (18%), Positives = 525/1327 (39%), Gaps = 212/1327 (15%)
Query: 412 EETEVQEQMNLLNSRWECLRVASMEKQSNL---HRVLMDLQNQKLKELNDWLTKTEERTR 468
+ET V+++++LLNS W + + E+ NL ++ M+ +Q + + W+ + +
Sbjct: 304 KETLVEDKLSLLNSNWIAV-TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 362
Query: 469 KMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ 528
+ E++ + LKR L+ +L + +V+S + + GDH +E Q
Sbjct: 363 ESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 415
Query: 529 LKVLGDRWANICR--WTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGF 586
+ L R+A I T + L+++ Q ++ Q L +E + VN
Sbjct: 416 ISELNHRFAAISHRIKTGKASIPLKEL---EQFNSDIQKLLEPLEAEIQQGVNLKEEDFN 472
Query: 587 KDQNEMLSSLQKLAVLKADL-------EKKKQSMGKLYSLKQDLLSTLKN---------- 629
KD NE K + + D E+K++ + +KQ LL T N
Sbjct: 473 KDMNEDNEGTVKELLQRGDNLQQRITDERKREEI----KIKQQLLQTKHNALKDLRSQRR 528
Query: 630 KSVTQKTEAW------LDNFARCWDNLVQKL--------EKSTAQISQAVTTTQPSLTQT 675
K + + W D+ +C D++ +KL E+ +I + + + L
Sbjct: 529 KKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAV 588
Query: 676 --------------TVMETVTTVTTR-EQILVKHAQ------EELPPPPPQKKRQITVD- 713
V T ++ R +I K AQ ++ + +T D
Sbjct: 589 RRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDM 648
Query: 714 ----SEIRKRLDVDITELHSWITRSEAVLQSPEFA------IFRKEGNFSDLKEKV---- 759
S + +IT + + E +L +P+ +F++E + ++K+ +
Sbjct: 649 PLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSS 708
Query: 760 NAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERL 819
I+ ++K LQ A+ V +++A QL+ +W + ++ +R
Sbjct: 709 GRIDIIHSKKTAALQSAT-------------PVERVKLQEALSQLDFQWEKVNKMYKDRQ 755
Query: 820 --------NWLEYQNNIIAFYNQLQQLEQM---TTTAENWLKIQPTTPSEPTAIKSQLKI 868
W + +I F L + EQ T ENW E K LK
Sbjct: 756 GRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW---------EHAKYKWYLKE 806
Query: 869 CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKEL 928
+D + + + + + I K + L + +++V + R+K L
Sbjct: 807 LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASI-LQEKLGSLNLRWQEVCKQLSDRKKRL 865
Query: 929 QTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQ 988
+ + L +Q ++ W+++++ SIP L + ++++L +++ L L +
Sbjct: 866 EEQKNIL--SEFQRDLNEFVLWLEEADNIASIP-LEPGKEQQLKEKLEQVKLLVEELPLR 922
Query: 989 QSGLYYLSTTVKEMSKKAP--SEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKL 1046
Q L L+ T + AP E K +++ ++ +W K+S L E ++E Q+ L
Sbjct: 923 QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDL 982
Query: 1047 RKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD----IQTIQPSLN 1102
+++ ++ L++ + + ++L P EI + ++ V + +Q QP +
Sbjct: 983 GQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 1039
Query: 1103 SVNEGGQKIKNEAEPEFASRLETELKELNTQW---DHMCQQVYARKEALKGGL------- 1152
+ GQ + E ++ +L++L+++W + + Q++ A++ L GL
Sbjct: 1040 EILSKGQHLYKEKPA--TQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 1097
Query: 1153 EKTVSL-------------------------------QKDLSEMHEWMTQAEEEYLERDF 1181
+TV+L + +E+ +W++ ++ +
Sbjct: 1098 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 1157
Query: 1182 EYKTPDELQKAVEEMKRAKEEAQQKEAKV-KLLTESVNSVIAQAPPVAQEALKKELETLT 1240
+++ + + + K ++ +Q+ ++ +L+T + N + A+ + +E +
Sbjct: 1158 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 1217
Query: 1241 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1300
+ + L + + L E+ + L E+A + L + KL++ + P + I +
Sbjct: 1218 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 1277
Query: 1301 VLDSLENL---MRHSEDNPNQIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAV 1355
+ + L +R + N + LA L D+ ++ E N+ WR +H+
Sbjct: 1278 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 1337
Query: 1356 RRQKLLEQSIQSAQ----ETEKSLHLIQESLTFID-----KQLAAYIADKVDAAQMPQEA 1406
R+ LE++ + Q + EK L + E+ T + + + D ++ ++
Sbjct: 1338 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 1397
Query: 1407 QKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQ 1465
Q +Q ++ +H + +++Q + + Q++L +++ K+ L +K N
Sbjct: 1398 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 1457
Query: 1466 RLQESK-------MILDEVKMHLPALETKSVEQEVVQSQ---LNHCVNLYKSLSEVKSEV 1515
L+ S + L E+ + L + + Q + + +++++
Sbjct: 1458 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 1517
Query: 1516 EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 1575
E VI + + V+ TE P E E KL+ ER Q + + L RK +E
Sbjct: 1518 EPVIMSTLETVRIFLTEQPLEGLE-----KLYQEPRELPPEERAQNVTRLL---RKQAEE 1569
Query: 1576 MNVLTEW 1582
+N TEW
Sbjct: 1570 VN--TEW 1574
Score = 65.9 bits (159), Expect = 7e-10
Identities = 76/369 (20%), Positives = 140/369 (37%), Gaps = 28/369 (7%)
Query: 298 TQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDT 357
TQ + T LE P SSLM L + A E+ WL +
Sbjct: 1098 TQTVTLVTQPVVTKETAISKLEMP------SSLMLEVPALADFNRAWTELTDWLSLLDQV 1151
Query: 358 LQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQ 417
+++Q + D+E + + + M DL + ++ ++ L +T Q
Sbjct: 1152 IKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNL--------KNKTSNQ 1203
Query: 418 EQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTR-------KM 470
E ++ R E ++ E Q +L L N+ LK+ WL EE + K+
Sbjct: 1204 EARTIITDRIERIQNQWDEVQEHLQNRRQQL-NEMLKDSTQWLEAKEEAEQVLGQARAKL 1262
Query: 471 EEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQL 529
E GP ++ +++++ + K L +DL Q Q V+ + + + T +
Sbjct: 1263 ESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMIT 1322
Query: 530 KVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFK-- 587
+ + W +I + +R L++ Q+ + F AWL+E E N + K
Sbjct: 1323 ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKER 1382
Query: 588 ---DQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 644
D + +++ L+ ++E L Q +L +L+ + LDN
Sbjct: 1383 LLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMN 1442
Query: 645 RCWDNLVQK 653
W L +K
Sbjct: 1443 FKWSELRKK 1451
Score = 47.4 bits (111), Expect = 3e-04
Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)
Query: 259 EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 318
E H ++H + + Q + +G + + R + + + S RS HL
Sbjct: 1405 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 1459
Query: 319 EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 378
EA D+ R +L+E+L WL +D L Q I D V+ Q H
Sbjct: 1460 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 1507
Query: 379 EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 420
+ +L + + + L+ L G KL ++ EE +++Q
Sbjct: 1508 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 1567
Query: 421 NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 475
+N+ WE L + S + Q + L ++L+EL + + + + R+ E +P+
Sbjct: 1568 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 1622
Query: 476 GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 531
G L D L+ +++ K L+ + L++ VN L + + + + LE+
Sbjct: 1623 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 1678
Query: 532 LGDRWANICRWTEDR 546
L RW + EDR
Sbjct: 1679 LNTRWKLLQVAVEDR 1693
>gi|5032293 dystrophin Dp140 isoform [Homo sapiens]
Length = 1225
Score = 2452 bits (6355), Expect = 0.0
Identities = 1225/1225 (100%), Positives = 1225/1225 (100%)
Query: 2457 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2516
MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
Sbjct: 1 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 60
Query: 2517 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2576
EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
Sbjct: 61 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 120
Query: 2577 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2636
DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
Sbjct: 121 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 180
Query: 2637 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2696
NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
Sbjct: 181 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 240
Query: 2697 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2756
FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
Sbjct: 241 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 300
Query: 2757 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2816
KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
Sbjct: 301 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 360
Query: 2817 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 2876
LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
Sbjct: 361 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 420
Query: 2877 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 2936
LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
Sbjct: 421 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 480
Query: 2937 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 2996
EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
Sbjct: 481 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 540
Query: 2997 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 3056
QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
Sbjct: 541 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 600
Query: 3057 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 3116
WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
Sbjct: 601 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 660
Query: 3117 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 3176
LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
Sbjct: 661 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 720
Query: 3177 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 3236
WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
Sbjct: 721 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 780
Query: 3237 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 3296
SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
Sbjct: 781 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 840
Query: 3297 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 3356
VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
Sbjct: 841 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 900
Query: 3357 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 3416
TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS
Sbjct: 901 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 960
Query: 3417 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 3476
APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN
Sbjct: 961 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 1020
Query: 3477 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 3536
QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP
Sbjct: 1021 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 1080
Query: 3537 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 3596
SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP
Sbjct: 1081 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 1140
Query: 3597 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 3656
QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM
Sbjct: 1141 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 1200
Query: 3657 EQLNNSFPSSRGRNTPGKPMREDTM 3681
EQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 1201 EQLNNSFPSSRGRNTPGKPMREDTM 1225
Score = 100 bits (249), Expect = 3e-20
Identities = 166/775 (21%), Positives = 312/775 (40%), Gaps = 89/775 (11%)
Query: 2001 THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAAL 2059
T ++ L ++Q++ + + D ED+ + K L+Q +++ +I + +
Sbjct: 20 TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 79
Query: 2060 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT-- 2117
+++ R + + + ++ QW++V + ++R+ + + +K QWL
Sbjct: 80 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAK 129
Query: 2118 -EAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTVVRTLNATGEEIIQ 2167
EAEQ L + + E+W+ Y K+L + Q QT V N ++++
Sbjct: 130 EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 189
Query: 2168 QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 2227
S D + ++N W+ + K++S+R+ LEE +L +F DL +F+ WL EA+
Sbjct: 190 DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 249
Query: 2228 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPIS 2280
A++ + ++++L E + VK L+++ QG + L+E +L S S
Sbjct: 250 TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS 309
Query: 2281 PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 2340
++ L+ +L N +W ++ + + +EA +L L++ LL+WL
Sbjct: 310 -DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE-------LLVWL 361
Query: 2341 SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE 2400
E+ Q G F AVQ KQ DV + L ++P +
Sbjct: 362 Q--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVR 410
Query: 2401 DLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQPVVTKETAISKLEM 2457
+E + + +L QE R P+ Q VT L+ + T KL +
Sbjct: 411 IFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQAEEVNTEWEKLNL 460
Query: 2458 PSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL--EDINEMIIKQKA 2511
S+ ++ + + E TD L L +VIK VGDL + + + + K KA
Sbjct: 461 HSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 520
Query: 2512 TMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 2571
++ + + + A+ L + T +E + +W +Q +++R +QL
Sbjct: 521 LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWKLLQVAVEDRVRQL 578
Query: 2572 NEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQKKITETKQLAKDL 2626
+E +D S +L + + K+ + T K+TE Q DL
Sbjct: 579 HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 638
Query: 2627 RQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-ASWRSIHKRVSERE 2677
+ + + L L LL +A D H + +N I ++
Sbjct: 639 NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 698
Query: 2678 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 2732
LE+ H L PL ++ L WL T T + R+L G+ L K
Sbjct: 699 DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFKTGIISLCK 748
Score = 81.3 bits (199), Expect = 2e-14
Identities = 116/572 (20%), Positives = 235/572 (41%), Gaps = 76/572 (13%)
Query: 1056 LKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA 1115
L W++ +D +K + +GD E + + + + + + D++ +P L + Q +KN+
Sbjct: 22 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81
Query: 1116 EPEFASRLETE-LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE 1174
+ A + T+ ++ + QWD + + + R++ L L+ + + E + + QA
Sbjct: 82 SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141
Query: 1175 EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKK 1234
+ T D +QK + E K+ ++ +Q + V + + ++ A + K
Sbjct: 142 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYS--ADDTRKV 199
Query: 1235 ELETLTTNYQW--LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIP 1292
+ T N W + R++ + LEE + LEK WL E E TT N+
Sbjct: 200 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVL 255
Query: 1293 GGA---EEISEVLDSLENLMRHSED---------------NPNQIRILAQTLTDGGVMDE 1334
A E + E ++ LM+ +D + N +IL +G
Sbjct: 256 QDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS--LEGSDDAV 313
Query: 1335 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL-IQESLTFI---DKQLA 1390
L+ L+ N +W EL ++++ + ++++ + K LHL +QE L ++ D +L+
Sbjct: 314 LLQRRLDNMNFKWSELRKKSLN----IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELS 369
Query: 1391 --AYIADKVDAAQMPQEAQK------------IQSDLTSHEISLEEM------KKHNQGK 1430
A I A Q + + I S L + I L E K + + +
Sbjct: 370 RQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPR 429
Query: 1431 E--AAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1487
E +R + + +K+ ++V+ ++ +L A++++++ E+ L E++ L+ K
Sbjct: 430 ELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLK 489
Query: 1488 SVEQEVV---------------QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTE 1532
+ EV+ Q L L ++ +K V V RQ+
Sbjct: 490 LRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL 549
Query: 1533 NPKELDERVTALKLHYNELGAKVTERKQQLEK 1564
+P L + L + L V +R +QL +
Sbjct: 550 SPYNL-STLEDLNTRWKLLQVAVEDRVRQLHE 580
Score = 65.5 bits (158), Expect = 9e-10
Identities = 70/339 (20%), Positives = 133/339 (39%), Gaps = 22/339 (6%)
Query: 328 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 387
SSLM L + A E+ WL + +++Q + D+E + + + M DL
Sbjct: 3 SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQ 62
Query: 388 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 447
+ ++ ++ L +T QE ++ R E ++ E Q +L
Sbjct: 63 RRPQLEELITAAQNL--------KNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 114
Query: 448 LQNQKLKELNDWLTKTEERTR-------KMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQE 499
L N+ LK+ WL EE + K+E GP ++ +++++ + K L +DL Q
Sbjct: 115 L-NEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQW 173
Query: 500 QVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQR 559
Q V+ + + + T + + + W +I + +R L++ Q+
Sbjct: 174 QTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQ 233
Query: 560 LTEEQCLFSAWLSEKEDAVNKIHTTGFK-----DQNEMLSSLQKLAVLKADLEKKKQSMG 614
+ F AWL+E E N + K D + +++ L+ ++E
Sbjct: 234 FPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYH 293
Query: 615 KLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQK 653
L Q +L +L+ + LDN W L +K
Sbjct: 294 NLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKK 332
Score = 65.5 bits (158), Expect = 9e-10
Identities = 85/480 (17%), Positives = 199/480 (41%), Gaps = 57/480 (11%)
Query: 940 YQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTV 999
+ + + W+ + + ++ V D E + + + + +A L++++ L L T
Sbjct: 15 FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAA 74
Query: 1000 KEMSKKAPSEISRKYQSE-FEEIEGRWKKLSSQLVEHCQKLEEQMNK----LRKIQNHIQ 1054
+ + K ++ +R ++ E I+ +W ++ L Q+L E + L + Q
Sbjct: 75 QNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 134
Query: 1055 TLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNE 1114
L + A+++ + +E P D+ ++K++ + + L D++ Q +++ N+ K+ +
Sbjct: 135 VLGQARAKLESW--KEGPYTVDA--IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRD 190
Query: 1115 AEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAE- 1173
+ ++ + +N W + ++V R+ AL+ DL + W+T+AE
Sbjct: 191 YSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAET 250
Query: 1174 -EEYLERDFEYKTPDELQKAVEEMKRAKEEAQ---QKEAKVKLLTESVNSVIAQAPPVAQ 1229
L+ + E K V+E+ + ++ Q + V + + I ++ +
Sbjct: 251 TANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD 310
Query: 1230 EALKKELETLTTNYQWLCTR-----LNGKCKTLEEVWACWH----ELLSYL--------- 1271
+A+ + N++W R + + + W H ELL +L
Sbjct: 311 DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR 370
Query: 1272 -----------EKANKWLNEVEFKLKTTENIPGGAEEISEV------LDSLENLMRHSED 1314
+K N + +LKT E + E + L+ LE L + +
Sbjct: 371 QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE 430
Query: 1315 NPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1374
P + R AQ +T L+ ++ E N+ W +L+ + Q+ ++++++ QE +++
Sbjct: 431 LPPEER--AQNVT------RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEA 482
Score = 62.0 bits (149), Expect = 1e-08
Identities = 104/571 (18%), Positives = 222/571 (38%), Gaps = 46/571 (8%)
Query: 725 TELHSWITRSEAVLQSPEFAIFRKEGNFSDLKE---KVNAIEREKAEKFRKLQDASRSAQ 781
TEL W++ + V++S + G+ D+ E K A ++ ++ +L++ +AQ
Sbjct: 20 TELTDWLSLLDQVIKSQRVMV----GDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 75
Query: 782 ALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQ 840
L + N+ I E++ ++W E + L R L E + + ++ EQ
Sbjct: 76 NLKNKTSNQEART-IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 134
Query: 841 MTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGP 900
+ A L+ P AI+ ++ K L Q ++ ++ L
Sbjct: 135 VLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD 194
Query: 901 MFLDADFVA--FTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKL 958
+ ++ + V RE L+ L ++ + W+ ++ET
Sbjct: 195 DTRKVHMITENINASWRSIHKRVSEREAALEETHRLL--QQFPLDLEKFLAWLTEAETTA 252
Query: 959 SIPQLSVTDYEIMEQRLG------ELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEIS 1011
++ Q + ++E G + Q LQ ++ + L +++ + S+ +
Sbjct: 253 NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDA 312
Query: 1012 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1071
Q + + +W +L + + LE ++ +++ +Q L W+ D L +
Sbjct: 313 VLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQA 372
Query: 1072 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV------------NEGGQKI---KNEAE 1116
P GD ++KQ R +++T +P + S EG +K+ E
Sbjct: 373 PIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELP 432
Query: 1117 PEFASR-----LETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1171
PE ++ L + +E+NT+W+ + + + LE+ LQ+ E+ + Q
Sbjct: 433 PEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQ 492
Query: 1172 AEEEYLERDFEYKTP---DELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA 1228
A E ++ ++ D LQ +E++K + E + V + + + ++
Sbjct: 493 A--EVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLS 550
Query: 1229 QEALKKELETLTTNYQWLCTRLNGKCKTLEE 1259
L LE L T ++ L + + + L E
Sbjct: 551 PYNL-STLEDLNTRWKLLQVAVEDRVRQLHE 580
Score = 60.8 bits (146), Expect = 2e-08
Identities = 74/446 (16%), Positives = 186/446 (41%), Gaps = 40/446 (8%)
Query: 1506 KSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL-DERVTALKLHYNELGAKVTERKQQLEK 1564
+ L + + ++E +I + + K + + + +R+ ++ ++E+ + R+QQL +
Sbjct: 58 QDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNE 117
Query: 1565 CLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 1624
LK S + + + L +L + ++ K K++ + + ++
Sbjct: 118 MLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNV 177
Query: 1625 KSITEVGEALKTVLGKKETLVEDKLSL-LNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 1683
++ L +T ++ +N++W ++ R E L E + ++ F +
Sbjct: 178 DVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 237
Query: 1684 VDHITKWIIQADT----LLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 1739
++ W+ +A+T L D + K++ + +K L + D++ ++++ D NL
Sbjct: 238 LEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDE 297
Query: 1740 N--------RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1791
N G L++ ++ +N +++ + K S+ ++ + +SD K L
Sbjct: 298 NSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR------KKSLNIRSHLEASSDQWKRLH 351
Query: 1792 PLEAEIQQGVNLKEEDFNKD------------MNEDNEGTVKELLQRGDNLQQRITDER- 1838
E+ + LK+++ ++ N+ + +EL + + + R
Sbjct: 352 LSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRI 411
Query: 1839 --KREEIKIKQQLLQTKHNALKDLRSQR-----RKKALEISHQWYQYKRQADDLLKCLDD 1891
+ ++ ++L Q + R+Q RK+A E++ +W + + D + +D+
Sbjct: 412 FLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDE 471
Query: 1892 IEKKLASLPEPRDERKIKEIDRELQK 1917
++L L E DE +K E+ K
Sbjct: 472 TLERLQELQEATDELDLKLRQAEVIK 497
Score = 55.8 bits (133), Expect = 8e-07
Identities = 96/533 (18%), Positives = 216/533 (40%), Gaps = 75/533 (14%)
Query: 1340 LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDA 1399
L FN W EL + LL+Q I+S + L I E + I K
Sbjct: 12 LADFNRAWTELTDWL----SLLDQVIKSQRVMVGDLEDINEMI----------IKQKATM 57
Query: 1400 AQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAA-------QRVLSQIDVAQKKLQDVSM 1452
+ Q +++ +T+ + +K +EA +R+ +Q D Q+ LQ+
Sbjct: 58 QDLEQRRPQLEELITA----AQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQ 113
Query: 1453 KFR-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEV 1511
+ + + + + +E++ +L + + L + + + +Q ++ L K L +
Sbjct: 114 QLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQW 173
Query: 1512 KSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1571
++ V++ ++++ ++ +++ + + + +V+ER+ LE+ +L ++
Sbjct: 174 QTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQ 233
Query: 1572 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG-KATQKEIEKQKVHLKSITEV 1630
++ WL T+ E T + E + G K K+ + + +++ T+V
Sbjct: 234 FPLDLEKFLAWL--TEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDV 291
Query: 1631 --------GEALKTVLGKKE-TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFD 1681
+ L+++ G + L++ +L +N W + ++ + L +
Sbjct: 292 YHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLH 351
Query: 1682 QNVDHITKWIIQADTLLDESEKKKP--------QQKEDVLKRLKAELNDIRPKVDSTRDQ 1733
++ + W+ D DE ++ P Q++ DV + K EL P + ST +
Sbjct: 352 LSLQELLVWLQLKD---DELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET 408
Query: 1734 AANLMANRG-DHCRKLV-EPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1791
+ + + KL EP+ R ++ ++ K+ E+ N++ +KL
Sbjct: 409 VRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR--------KQAEEVNTEWEKL-- 458
Query: 1792 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIK 1844
NL D+ + ++E E ++EL + D L ++ R+ E IK
Sbjct: 459 ----------NLHSADWQRKIDETLE-RLQELQEATDELDLKL---RQAEVIK 497
Score = 49.7 bits (117), Expect = 5e-05
Identities = 91/510 (17%), Positives = 215/510 (42%), Gaps = 53/510 (10%)
Query: 1277 WLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRIL---AQTL---TDGG 1330
WL+ ++ +K+ + G E+I+E++ + M+ E Q+ L AQ L T
Sbjct: 25 WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 84
Query: 1331 VMDELINEELETFNSRWRELHEEAVRRQ----KLLEQSIQSAQETEKSLHLIQESLTFID 1386
+I + +E ++W E+ E R+ ++L+ S Q + E++ ++ ++ ++
Sbjct: 85 EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 144
Query: 1387 K-QLAAYIADKV-----DAAQMPQEAQKIQSDL-TSHEISLEEMKKHNQGKEAAQRVLSQ 1439
+ Y D + + Q+ ++ ++ Q+++ +++++L+ ++ ++ ++++
Sbjct: 145 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE 204
Query: 1440 IDVAQKKLQDVSMKFRLFQKPANFEQR---LQESKMILDEVKMHLPALET------KSVE 1490
A + S+ R+ ++ A E+ LQ+ + L++ L ET +
Sbjct: 205 NINASWR----SIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATR 260
Query: 1491 QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ--------TENPKELDERVT 1542
+E + L K +++ E+E + + Q +++ L R+
Sbjct: 261 KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLD 320
Query: 1543 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1602
+ ++EL K + LE +++ + L WL D EL++++ + G
Sbjct: 321 NMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPA 380
Query: 1603 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKT--VLGKKETLVEDKLSLLNSNWIAVT 1660
+ + +A ++E++ ++ + S E T L E L ++ L
Sbjct: 381 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL------PPE 434
Query: 1661 SRAEEWLNLLLEYQKHMETFDQNVD-HITKWIIQADTLLDESEKKKPQQKEDVLKRLKAE 1719
RA+ LL + + + T + ++ H W + D L+ ++ + E LK +AE
Sbjct: 435 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 494
Query: 1720 L--NDIRP----KVDSTRDQAANLMANRGD 1743
+ +P +DS +D + A RG+
Sbjct: 495 VIKGSWQPVGDLLIDSLQDHLEKVKALRGE 524
Score = 47.4 bits (111), Expect = 3e-04
Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)
Query: 259 EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 318
E H ++H + + Q + +G + + R + + + S RS HL
Sbjct: 286 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 340
Query: 319 EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 378
EA D+ R +L+E+L WL +D L Q I D V+ Q H
Sbjct: 341 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 388
Query: 379 EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 420
+ +L + + + L+ L G KL ++ EE +++Q
Sbjct: 389 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 448
Query: 421 NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 475
+N+ WE L + S + Q + L ++L+EL + + + + R+ E +P+
Sbjct: 449 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 503
Query: 476 GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 531
G L D L+ +++ K L+ + L++ VN L + + + + LE+
Sbjct: 504 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 559
Query: 532 LGDRWANICRWTEDR 546
L RW + EDR
Sbjct: 560 LNTRWKLLQVAVEDR 574
Score = 35.0 bits (79), Expect = 1.4
Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)
Query: 2263 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 2318
L ++ + G L + ISP E E+ L Q Q + L + + I + ++
Sbjct: 984 LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 1042
Query: 2319 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 2378
G+LE+ L DLEE+ +L ++ Q E P ++ T + P E+
Sbjct: 1043 RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 1098
Query: 2379 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 2435
+++ + L + K + + LED + + ++ ++RL Q L Q + TT+ + T
Sbjct: 1099 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 1156
>gi|5032309 dystrophin Dp140b isoform [Homo sapiens]
Length = 1243
Score = 2427 bits (6289), Expect = 0.0
Identities = 1213/1214 (99%), Positives = 1213/1214 (99%)
Query: 2457 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2516
MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
Sbjct: 1 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 60
Query: 2517 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2576
EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
Sbjct: 61 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 120
Query: 2577 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2636
DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
Sbjct: 121 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 180
Query: 2637 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2696
NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
Sbjct: 181 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 240
Query: 2697 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2756
FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
Sbjct: 241 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 300
Query: 2757 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2816
KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
Sbjct: 301 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 360
Query: 2817 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 2876
LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
Sbjct: 361 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 420
Query: 2877 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 2936
LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
Sbjct: 421 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 480
Query: 2937 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 2996
EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
Sbjct: 481 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 540
Query: 2997 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 3056
QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
Sbjct: 541 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 600
Query: 3057 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 3116
WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
Sbjct: 601 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 660
Query: 3117 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 3176
LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
Sbjct: 661 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 720
Query: 3177 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 3236
WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
Sbjct: 721 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 780
Query: 3237 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 3296
SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
Sbjct: 781 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 840
Query: 3297 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 3356
VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
Sbjct: 841 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 900
Query: 3357 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 3416
TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS
Sbjct: 901 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 960
Query: 3417 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 3476
APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN
Sbjct: 961 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 1020
Query: 3477 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 3536
QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP
Sbjct: 1021 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 1080
Query: 3537 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 3596
SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP
Sbjct: 1081 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 1140
Query: 3597 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 3656
QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM
Sbjct: 1141 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 1200
Query: 3657 EQLNNSFPSSRGRN 3670
EQLNNSFPSSRG N
Sbjct: 1201 EQLNNSFPSSRGHN 1214
Score = 100 bits (249), Expect = 3e-20
Identities = 166/775 (21%), Positives = 312/775 (40%), Gaps = 89/775 (11%)
Query: 2001 THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAAL 2059
T ++ L ++Q++ + + D ED+ + K L+Q +++ +I + +
Sbjct: 20 TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 79
Query: 2060 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT-- 2117
+++ R + + + ++ QW++V + ++R+ + + +K QWL
Sbjct: 80 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAK 129
Query: 2118 -EAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTVVRTLNATGEEIIQ 2167
EAEQ L + + E+W+ Y K+L + Q QT V N ++++
Sbjct: 130 EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 189
Query: 2168 QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 2227
S D + ++N W+ + K++S+R+ LEE +L +F DL +F+ WL EA+
Sbjct: 190 DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 249
Query: 2228 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPIS 2280
A++ + ++++L E + VK L+++ QG + L+E +L S S
Sbjct: 250 TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS 309
Query: 2281 PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 2340
++ L+ +L N +W ++ + + +EA +L L++ LL+WL
Sbjct: 310 -DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE-------LLVWL 361
Query: 2341 SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE 2400
E+ Q G F AVQ KQ DV + L ++P +
Sbjct: 362 Q--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVR 410
Query: 2401 DLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQPVVTKETAISKLEM 2457
+E + + +L QE R P+ Q VT L+ + T KL +
Sbjct: 411 IFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQAEEVNTEWEKLNL 460
Query: 2458 PSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL--EDINEMIIKQKA 2511
S+ ++ + + E TD L L +VIK VGDL + + + + K KA
Sbjct: 461 HSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 520
Query: 2512 TMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 2571
++ + + + A+ L + T +E + +W +Q +++R +QL
Sbjct: 521 LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWKLLQVAVEDRVRQL 578
Query: 2572 NEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQKKITETKQLAKDL 2626
+E +D S +L + + K+ + T K+TE Q DL
Sbjct: 579 HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 638
Query: 2627 RQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-ASWRSIHKRVSERE 2677
+ + + L L LL +A D H + +N I ++
Sbjct: 639 NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 698
Query: 2678 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 2732
LE+ H L PL ++ L WL T T + R+L G+ L K
Sbjct: 699 DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFKTGIISLCK 748
Score = 81.3 bits (199), Expect = 2e-14
Identities = 116/572 (20%), Positives = 235/572 (41%), Gaps = 76/572 (13%)
Query: 1056 LKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA 1115
L W++ +D +K + +GD E + + + + + + D++ +P L + Q +KN+
Sbjct: 22 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81
Query: 1116 EPEFASRLETE-LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE 1174
+ A + T+ ++ + QWD + + + R++ L L+ + + E + + QA
Sbjct: 82 SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141
Query: 1175 EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKK 1234
+ T D +QK + E K+ ++ +Q + V + + ++ A + K
Sbjct: 142 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYS--ADDTRKV 199
Query: 1235 ELETLTTNYQW--LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIP 1292
+ T N W + R++ + LEE + LEK WL E E TT N+
Sbjct: 200 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVL 255
Query: 1293 GGA---EEISEVLDSLENLMRHSED---------------NPNQIRILAQTLTDGGVMDE 1334
A E + E ++ LM+ +D + N +IL +G
Sbjct: 256 QDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS--LEGSDDAV 313
Query: 1335 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL-IQESLTFI---DKQLA 1390
L+ L+ N +W EL ++++ + ++++ + K LHL +QE L ++ D +L+
Sbjct: 314 LLQRRLDNMNFKWSELRKKSLN----IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELS 369
Query: 1391 --AYIADKVDAAQMPQEAQK------------IQSDLTSHEISLEEM------KKHNQGK 1430
A I A Q + + I S L + I L E K + + +
Sbjct: 370 RQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPR 429
Query: 1431 E--AAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1487
E +R + + +K+ ++V+ ++ +L A++++++ E+ L E++ L+ K
Sbjct: 430 ELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLK 489
Query: 1488 SVEQEVV---------------QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTE 1532
+ EV+ Q L L ++ +K V V RQ+
Sbjct: 490 LRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL 549
Query: 1533 NPKELDERVTALKLHYNELGAKVTERKQQLEK 1564
+P L + L + L V +R +QL +
Sbjct: 550 SPYNL-STLEDLNTRWKLLQVAVEDRVRQLHE 580
Score = 65.5 bits (158), Expect = 9e-10
Identities = 70/339 (20%), Positives = 133/339 (39%), Gaps = 22/339 (6%)
Query: 328 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 387
SSLM L + A E+ WL + +++Q + D+E + + + M DL
Sbjct: 3 SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQ 62
Query: 388 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 447
+ ++ ++ L +T QE ++ R E ++ E Q +L
Sbjct: 63 RRPQLEELITAAQNL--------KNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 114
Query: 448 LQNQKLKELNDWLTKTEERTR-------KMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQE 499
L N+ LK+ WL EE + K+E GP ++ +++++ + K L +DL Q
Sbjct: 115 L-NEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQW 173
Query: 500 QVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQR 559
Q V+ + + + T + + + W +I + +R L++ Q+
Sbjct: 174 QTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQ 233
Query: 560 LTEEQCLFSAWLSEKEDAVNKIHTTGFK-----DQNEMLSSLQKLAVLKADLEKKKQSMG 614
+ F AWL+E E N + K D + +++ L+ ++E
Sbjct: 234 FPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYH 293
Query: 615 KLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQK 653
L Q +L +L+ + LDN W L +K
Sbjct: 294 NLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKK 332
Score = 65.5 bits (158), Expect = 9e-10
Identities = 85/480 (17%), Positives = 199/480 (41%), Gaps = 57/480 (11%)
Query: 940 YQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTV 999
+ + + W+ + + ++ V D E + + + + +A L++++ L L T
Sbjct: 15 FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAA 74
Query: 1000 KEMSKKAPSEISRKYQSE-FEEIEGRWKKLSSQLVEHCQKLEEQMNK----LRKIQNHIQ 1054
+ + K ++ +R ++ E I+ +W ++ L Q+L E + L + Q
Sbjct: 75 QNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 134
Query: 1055 TLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNE 1114
L + A+++ + +E P D+ ++K++ + + L D++ Q +++ N+ K+ +
Sbjct: 135 VLGQARAKLESW--KEGPYTVDA--IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRD 190
Query: 1115 AEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAE- 1173
+ ++ + +N W + ++V R+ AL+ DL + W+T+AE
Sbjct: 191 YSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAET 250
Query: 1174 -EEYLERDFEYKTPDELQKAVEEMKRAKEEAQ---QKEAKVKLLTESVNSVIAQAPPVAQ 1229
L+ + E K V+E+ + ++ Q + V + + I ++ +
Sbjct: 251 TANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD 310
Query: 1230 EALKKELETLTTNYQWLCTR-----LNGKCKTLEEVWACWH----ELLSYL--------- 1271
+A+ + N++W R + + + W H ELL +L
Sbjct: 311 DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR 370
Query: 1272 -----------EKANKWLNEVEFKLKTTENIPGGAEEISEV------LDSLENLMRHSED 1314
+K N + +LKT E + E + L+ LE L + +
Sbjct: 371 QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE 430
Query: 1315 NPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1374
P + R AQ +T L+ ++ E N+ W +L+ + Q+ ++++++ QE +++
Sbjct: 431 LPPEER--AQNVT------RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEA 482
Score = 62.0 bits (149), Expect = 1e-08
Identities = 104/571 (18%), Positives = 222/571 (38%), Gaps = 46/571 (8%)
Query: 725 TELHSWITRSEAVLQSPEFAIFRKEGNFSDLKE---KVNAIEREKAEKFRKLQDASRSAQ 781
TEL W++ + V++S + G+ D+ E K A ++ ++ +L++ +AQ
Sbjct: 20 TELTDWLSLLDQVIKSQRVMV----GDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 75
Query: 782 ALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQ 840
L + N+ I E++ ++W E + L R L E + + ++ EQ
Sbjct: 76 NLKNKTSNQEART-IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 134
Query: 841 MTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGP 900
+ A L+ P AI+ ++ K L Q ++ ++ L
Sbjct: 135 VLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD 194
Query: 901 MFLDADFVA--FTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKL 958
+ ++ + V RE L+ L ++ + W+ ++ET
Sbjct: 195 DTRKVHMITENINASWRSIHKRVSEREAALEETHRLL--QQFPLDLEKFLAWLTEAETTA 252
Query: 959 SIPQLSVTDYEIMEQRLG------ELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEIS 1011
++ Q + ++E G + Q LQ ++ + L +++ + S+ +
Sbjct: 253 NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDA 312
Query: 1012 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1071
Q + + +W +L + + LE ++ +++ +Q L W+ D L +
Sbjct: 313 VLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQA 372
Query: 1072 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV------------NEGGQKI---KNEAE 1116
P GD ++KQ R +++T +P + S EG +K+ E
Sbjct: 373 PIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELP 432
Query: 1117 PEFASR-----LETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1171
PE ++ L + +E+NT+W+ + + + LE+ LQ+ E+ + Q
Sbjct: 433 PEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQ 492
Query: 1172 AEEEYLERDFEYKTP---DELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA 1228
A E ++ ++ D LQ +E++K + E + V + + + ++
Sbjct: 493 A--EVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLS 550
Query: 1229 QEALKKELETLTTNYQWLCTRLNGKCKTLEE 1259
L LE L T ++ L + + + L E
Sbjct: 551 PYNL-STLEDLNTRWKLLQVAVEDRVRQLHE 580
Score = 60.8 bits (146), Expect = 2e-08
Identities = 74/446 (16%), Positives = 186/446 (41%), Gaps = 40/446 (8%)
Query: 1506 KSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL-DERVTALKLHYNELGAKVTERKQQLEK 1564
+ L + + ++E +I + + K + + + +R+ ++ ++E+ + R+QQL +
Sbjct: 58 QDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNE 117
Query: 1565 CLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 1624
LK S + + + L +L + ++ K K++ + + ++
Sbjct: 118 MLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNV 177
Query: 1625 KSITEVGEALKTVLGKKETLVEDKLSL-LNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 1683
++ L +T ++ +N++W ++ R E L E + ++ F +
Sbjct: 178 DVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 237
Query: 1684 VDHITKWIIQADT----LLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 1739
++ W+ +A+T L D + K++ + +K L + D++ ++++ D NL
Sbjct: 238 LEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDE 297
Query: 1740 N--------RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1791
N G L++ ++ +N +++ + K S+ ++ + +SD K L
Sbjct: 298 NSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR------KKSLNIRSHLEASSDQWKRLH 351
Query: 1792 PLEAEIQQGVNLKEEDFNKD------------MNEDNEGTVKELLQRGDNLQQRITDER- 1838
E+ + LK+++ ++ N+ + +EL + + + R
Sbjct: 352 LSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRI 411
Query: 1839 --KREEIKIKQQLLQTKHNALKDLRSQR-----RKKALEISHQWYQYKRQADDLLKCLDD 1891
+ ++ ++L Q + R+Q RK+A E++ +W + + D + +D+
Sbjct: 412 FLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDE 471
Query: 1892 IEKKLASLPEPRDERKIKEIDRELQK 1917
++L L E DE +K E+ K
Sbjct: 472 TLERLQELQEATDELDLKLRQAEVIK 497
Score = 55.8 bits (133), Expect = 8e-07
Identities = 96/533 (18%), Positives = 216/533 (40%), Gaps = 75/533 (14%)
Query: 1340 LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDA 1399
L FN W EL + LL+Q I+S + L I E + I K
Sbjct: 12 LADFNRAWTELTDWL----SLLDQVIKSQRVMVGDLEDINEMI----------IKQKATM 57
Query: 1400 AQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAA-------QRVLSQIDVAQKKLQDVSM 1452
+ Q +++ +T+ + +K +EA +R+ +Q D Q+ LQ+
Sbjct: 58 QDLEQRRPQLEELITA----AQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQ 113
Query: 1453 KFR-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEV 1511
+ + + + + +E++ +L + + L + + + +Q ++ L K L +
Sbjct: 114 QLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQW 173
Query: 1512 KSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1571
++ V++ ++++ ++ +++ + + + +V+ER+ LE+ +L ++
Sbjct: 174 QTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQ 233
Query: 1572 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG-KATQKEIEKQKVHLKSITEV 1630
++ WL T+ E T + E + G K K+ + + +++ T+V
Sbjct: 234 FPLDLEKFLAWL--TEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDV 291
Query: 1631 --------GEALKTVLGKKE-TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFD 1681
+ L+++ G + L++ +L +N W + ++ + L +
Sbjct: 292 YHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLH 351
Query: 1682 QNVDHITKWIIQADTLLDESEKKKP--------QQKEDVLKRLKAELNDIRPKVDSTRDQ 1733
++ + W+ D DE ++ P Q++ DV + K EL P + ST +
Sbjct: 352 LSLQELLVWLQLKD---DELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET 408
Query: 1734 AANLMANRG-DHCRKLV-EPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1791
+ + + KL EP+ R ++ ++ K+ E+ N++ +KL
Sbjct: 409 VRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR--------KQAEEVNTEWEKL-- 458
Query: 1792 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIK 1844
NL D+ + ++E E ++EL + D L ++ R+ E IK
Sbjct: 459 ----------NLHSADWQRKIDETLE-RLQELQEATDELDLKL---RQAEVIK 497
Score = 49.7 bits (117), Expect = 5e-05
Identities = 91/510 (17%), Positives = 215/510 (42%), Gaps = 53/510 (10%)
Query: 1277 WLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRIL---AQTL---TDGG 1330
WL+ ++ +K+ + G E+I+E++ + M+ E Q+ L AQ L T
Sbjct: 25 WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 84
Query: 1331 VMDELINEELETFNSRWRELHEEAVRRQ----KLLEQSIQSAQETEKSLHLIQESLTFID 1386
+I + +E ++W E+ E R+ ++L+ S Q + E++ ++ ++ ++
Sbjct: 85 EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 144
Query: 1387 K-QLAAYIADKV-----DAAQMPQEAQKIQSDL-TSHEISLEEMKKHNQGKEAAQRVLSQ 1439
+ Y D + + Q+ ++ ++ Q+++ +++++L+ ++ ++ ++++
Sbjct: 145 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE 204
Query: 1440 IDVAQKKLQDVSMKFRLFQKPANFEQR---LQESKMILDEVKMHLPALET------KSVE 1490
A + S+ R+ ++ A E+ LQ+ + L++ L ET +
Sbjct: 205 NINASWR----SIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATR 260
Query: 1491 QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ--------TENPKELDERVT 1542
+E + L K +++ E+E + + Q +++ L R+
Sbjct: 261 KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLD 320
Query: 1543 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1602
+ ++EL K + LE +++ + L WL D EL++++ + G
Sbjct: 321 NMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPA 380
Query: 1603 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKT--VLGKKETLVEDKLSLLNSNWIAVT 1660
+ + +A ++E++ ++ + S E T L E L ++ L
Sbjct: 381 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL------PPE 434
Query: 1661 SRAEEWLNLLLEYQKHMETFDQNVD-HITKWIIQADTLLDESEKKKPQQKEDVLKRLKAE 1719
RA+ LL + + + T + ++ H W + D L+ ++ + E LK +AE
Sbjct: 435 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 494
Query: 1720 L--NDIRP----KVDSTRDQAANLMANRGD 1743
+ +P +DS +D + A RG+
Sbjct: 495 VIKGSWQPVGDLLIDSLQDHLEKVKALRGE 524
Score = 47.4 bits (111), Expect = 3e-04
Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)
Query: 259 EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 318
E H ++H + + Q + +G + + R + + + S RS HL
Sbjct: 286 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 340
Query: 319 EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 378
EA D+ R +L+E+L WL +D L Q I D V+ Q H
Sbjct: 341 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 388
Query: 379 EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 420
+ +L + + + L+ L G KL ++ EE +++Q
Sbjct: 389 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 448
Query: 421 NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 475
+N+ WE L + S + Q + L ++L+EL + + + + R+ E +P+
Sbjct: 449 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 503
Query: 476 GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 531
G L D L+ +++ K L+ + L++ VN L + + + + LE+
Sbjct: 504 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 559
Query: 532 LGDRWANICRWTEDR 546
L RW + EDR
Sbjct: 560 LNTRWKLLQVAVEDR 574
Score = 35.0 bits (79), Expect = 1.4
Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)
Query: 2263 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 2318
L ++ + G L + ISP E E+ L Q Q + L + + I + ++
Sbjct: 984 LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 1042
Query: 2319 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 2378
G+LE+ L DLEE+ +L ++ Q E P ++ T + P E+
Sbjct: 1043 RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 1098
Query: 2379 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 2435
+++ + L + K + + LED + + ++ ++RL Q L Q + TT+ + T
Sbjct: 1099 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 1156
>gi|5032311 dystrophin Dp140ab isoform [Homo sapiens]
Length = 1230
Score = 2390 bits (6193), Expect = 0.0
Identities = 1200/1214 (98%), Positives = 1200/1214 (98%), Gaps = 13/1214 (1%)
Query: 2457 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2516
MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
Sbjct: 1 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 60
Query: 2517 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2576
EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
Sbjct: 61 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 120
Query: 2577 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2636
DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
Sbjct: 121 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 180
Query: 2637 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2696
NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
Sbjct: 181 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 240
Query: 2697 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2756
FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
Sbjct: 241 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 300
Query: 2757 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2816
KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
Sbjct: 301 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 360
Query: 2817 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 2876
LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
Sbjct: 361 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 420
Query: 2877 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 2936
LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
Sbjct: 421 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 480
Query: 2937 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 2996
EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
Sbjct: 481 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 540
Query: 2997 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 3056
QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
Sbjct: 541 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 600
Query: 3057 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 3116
WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
Sbjct: 601 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 660
Query: 3117 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 3176
LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
Sbjct: 661 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 720
Query: 3177 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 3236
WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
Sbjct: 721 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 780
Query: 3237 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 3296
SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
Sbjct: 781 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 840
Query: 3297 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 3356
VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
Sbjct: 841 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 900
Query: 3357 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 3416
TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET
Sbjct: 901 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET------------ 948
Query: 3417 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 3476
PASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN
Sbjct: 949 -PASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 1007
Query: 3477 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 3536
QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP
Sbjct: 1008 QDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLP 1067
Query: 3537 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 3596
SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP
Sbjct: 1068 SPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQP 1127
Query: 3597 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 3656
QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM
Sbjct: 1128 QAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVM 1187
Query: 3657 EQLNNSFPSSRGRN 3670
EQLNNSFPSSRG N
Sbjct: 1188 EQLNNSFPSSRGHN 1201
Score = 100 bits (249), Expect = 3e-20
Identities = 166/775 (21%), Positives = 312/775 (40%), Gaps = 89/775 (11%)
Query: 2001 THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAAL 2059
T ++ L ++Q++ + + D ED+ + K L+Q +++ +I + +
Sbjct: 20 TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 79
Query: 2060 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT-- 2117
+++ R + + + ++ QW++V + ++R+ + + +K QWL
Sbjct: 80 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAK 129
Query: 2118 -EAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTVVRTLNATGEEIIQ 2167
EAEQ L + + E+W+ Y K+L + Q QT V N ++++
Sbjct: 130 EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 189
Query: 2168 QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 2227
S D + ++N W+ + K++S+R+ LEE +L +F DL +F+ WL EA+
Sbjct: 190 DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 249
Query: 2228 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPIS 2280
A++ + ++++L E + VK L+++ QG + L+E +L S S
Sbjct: 250 TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS 309
Query: 2281 PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 2340
++ L+ +L N +W ++ + + +EA +L L++ LL+WL
Sbjct: 310 -DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE-------LLVWL 361
Query: 2341 SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE 2400
E+ Q G F AVQ KQ DV + L ++P +
Sbjct: 362 Q--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVR 410
Query: 2401 DLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQPVVTKETAISKLEM 2457
+E + + +L QE R P+ Q VT L+ + T KL +
Sbjct: 411 IFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQAEEVNTEWEKLNL 460
Query: 2458 PSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL--EDINEMIIKQKA 2511
S+ ++ + + E TD L L +VIK VGDL + + + + K KA
Sbjct: 461 HSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 520
Query: 2512 TMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 2571
++ + + + A+ L + T +E + +W +Q +++R +QL
Sbjct: 521 LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWKLLQVAVEDRVRQL 578
Query: 2572 NEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQKKITETKQLAKDL 2626
+E +D S +L + + K+ + T K+TE Q DL
Sbjct: 579 HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 638
Query: 2627 RQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-ASWRSIHKRVSERE 2677
+ + + L L LL +A D H + +N I ++
Sbjct: 639 NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 698
Query: 2678 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 2732
LE+ H L PL ++ L WL T T + R+L G+ L K
Sbjct: 699 DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFKTGIISLCK 748
Score = 81.3 bits (199), Expect = 2e-14
Identities = 116/572 (20%), Positives = 235/572 (41%), Gaps = 76/572 (13%)
Query: 1056 LKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA 1115
L W++ +D +K + +GD E + + + + + + D++ +P L + Q +KN+
Sbjct: 22 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81
Query: 1116 EPEFASRLETE-LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE 1174
+ A + T+ ++ + QWD + + + R++ L L+ + + E + + QA
Sbjct: 82 SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141
Query: 1175 EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKK 1234
+ T D +QK + E K+ ++ +Q + V + + ++ A + K
Sbjct: 142 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYS--ADDTRKV 199
Query: 1235 ELETLTTNYQW--LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIP 1292
+ T N W + R++ + LEE + LEK WL E E TT N+
Sbjct: 200 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVL 255
Query: 1293 GGA---EEISEVLDSLENLMRHSED---------------NPNQIRILAQTLTDGGVMDE 1334
A E + E ++ LM+ +D + N +IL +G
Sbjct: 256 QDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS--LEGSDDAV 313
Query: 1335 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL-IQESLTFI---DKQLA 1390
L+ L+ N +W EL ++++ + ++++ + K LHL +QE L ++ D +L+
Sbjct: 314 LLQRRLDNMNFKWSELRKKSLN----IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELS 369
Query: 1391 --AYIADKVDAAQMPQEAQK------------IQSDLTSHEISLEEM------KKHNQGK 1430
A I A Q + + I S L + I L E K + + +
Sbjct: 370 RQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPR 429
Query: 1431 E--AAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1487
E +R + + +K+ ++V+ ++ +L A++++++ E+ L E++ L+ K
Sbjct: 430 ELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLK 489
Query: 1488 SVEQEVV---------------QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTE 1532
+ EV+ Q L L ++ +K V V RQ+
Sbjct: 490 LRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL 549
Query: 1533 NPKELDERVTALKLHYNELGAKVTERKQQLEK 1564
+P L + L + L V +R +QL +
Sbjct: 550 SPYNL-STLEDLNTRWKLLQVAVEDRVRQLHE 580
Score = 65.5 bits (158), Expect = 9e-10
Identities = 70/339 (20%), Positives = 133/339 (39%), Gaps = 22/339 (6%)
Query: 328 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 387
SSLM L + A E+ WL + +++Q + D+E + + + M DL
Sbjct: 3 SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQ 62
Query: 388 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 447
+ ++ ++ L +T QE ++ R E ++ E Q +L
Sbjct: 63 RRPQLEELITAAQNL--------KNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 114
Query: 448 LQNQKLKELNDWLTKTEERTR-------KMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQE 499
L N+ LK+ WL EE + K+E GP ++ +++++ + K L +DL Q
Sbjct: 115 L-NEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQW 173
Query: 500 QVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQR 559
Q V+ + + + T + + + W +I + +R L++ Q+
Sbjct: 174 QTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQ 233
Query: 560 LTEEQCLFSAWLSEKEDAVNKIHTTGFK-----DQNEMLSSLQKLAVLKADLEKKKQSMG 614
+ F AWL+E E N + K D + +++ L+ ++E
Sbjct: 234 FPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYH 293
Query: 615 KLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQK 653
L Q +L +L+ + LDN W L +K
Sbjct: 294 NLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKK 332
Score = 65.5 bits (158), Expect = 9e-10
Identities = 85/480 (17%), Positives = 199/480 (41%), Gaps = 57/480 (11%)
Query: 940 YQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTV 999
+ + + W+ + + ++ V D E + + + + +A L++++ L L T
Sbjct: 15 FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAA 74
Query: 1000 KEMSKKAPSEISRKYQSE-FEEIEGRWKKLSSQLVEHCQKLEEQMNK----LRKIQNHIQ 1054
+ + K ++ +R ++ E I+ +W ++ L Q+L E + L + Q
Sbjct: 75 QNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 134
Query: 1055 TLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNE 1114
L + A+++ + +E P D+ ++K++ + + L D++ Q +++ N+ K+ +
Sbjct: 135 VLGQARAKLESW--KEGPYTVDA--IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRD 190
Query: 1115 AEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAE- 1173
+ ++ + +N W + ++V R+ AL+ DL + W+T+AE
Sbjct: 191 YSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAET 250
Query: 1174 -EEYLERDFEYKTPDELQKAVEEMKRAKEEAQ---QKEAKVKLLTESVNSVIAQAPPVAQ 1229
L+ + E K V+E+ + ++ Q + V + + I ++ +
Sbjct: 251 TANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD 310
Query: 1230 EALKKELETLTTNYQWLCTR-----LNGKCKTLEEVWACWH----ELLSYL--------- 1271
+A+ + N++W R + + + W H ELL +L
Sbjct: 311 DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR 370
Query: 1272 -----------EKANKWLNEVEFKLKTTENIPGGAEEISEV------LDSLENLMRHSED 1314
+K N + +LKT E + E + L+ LE L + +
Sbjct: 371 QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE 430
Query: 1315 NPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1374
P + R AQ +T L+ ++ E N+ W +L+ + Q+ ++++++ QE +++
Sbjct: 431 LPPEER--AQNVT------RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEA 482
Score = 62.0 bits (149), Expect = 1e-08
Identities = 104/571 (18%), Positives = 222/571 (38%), Gaps = 46/571 (8%)
Query: 725 TELHSWITRSEAVLQSPEFAIFRKEGNFSDLKE---KVNAIEREKAEKFRKLQDASRSAQ 781
TEL W++ + V++S + G+ D+ E K A ++ ++ +L++ +AQ
Sbjct: 20 TELTDWLSLLDQVIKSQRVMV----GDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 75
Query: 782 ALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQ 840
L + N+ I E++ ++W E + L R L E + + ++ EQ
Sbjct: 76 NLKNKTSNQEART-IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 134
Query: 841 MTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGP 900
+ A L+ P AI+ ++ K L Q ++ ++ L
Sbjct: 135 VLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD 194
Query: 901 MFLDADFVA--FTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKL 958
+ ++ + V RE L+ L ++ + W+ ++ET
Sbjct: 195 DTRKVHMITENINASWRSIHKRVSEREAALEETHRLL--QQFPLDLEKFLAWLTEAETTA 252
Query: 959 SIPQLSVTDYEIMEQRLG------ELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEIS 1011
++ Q + ++E G + Q LQ ++ + L +++ + S+ +
Sbjct: 253 NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDA 312
Query: 1012 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1071
Q + + +W +L + + LE ++ +++ +Q L W+ D L +
Sbjct: 313 VLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQA 372
Query: 1072 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV------------NEGGQKI---KNEAE 1116
P GD ++KQ R +++T +P + S EG +K+ E
Sbjct: 373 PIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELP 432
Query: 1117 PEFASR-----LETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1171
PE ++ L + +E+NT+W+ + + + LE+ LQ+ E+ + Q
Sbjct: 433 PEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQ 492
Query: 1172 AEEEYLERDFEYKTP---DELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA 1228
A E ++ ++ D LQ +E++K + E + V + + + ++
Sbjct: 493 A--EVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLS 550
Query: 1229 QEALKKELETLTTNYQWLCTRLNGKCKTLEE 1259
L LE L T ++ L + + + L E
Sbjct: 551 PYNL-STLEDLNTRWKLLQVAVEDRVRQLHE 580
Score = 60.8 bits (146), Expect = 2e-08
Identities = 74/446 (16%), Positives = 186/446 (41%), Gaps = 40/446 (8%)
Query: 1506 KSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL-DERVTALKLHYNELGAKVTERKQQLEK 1564
+ L + + ++E +I + + K + + + +R+ ++ ++E+ + R+QQL +
Sbjct: 58 QDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNE 117
Query: 1565 CLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 1624
LK S + + + L +L + ++ K K++ + + ++
Sbjct: 118 MLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNV 177
Query: 1625 KSITEVGEALKTVLGKKETLVEDKLSL-LNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 1683
++ L +T ++ +N++W ++ R E L E + ++ F +
Sbjct: 178 DVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 237
Query: 1684 VDHITKWIIQADT----LLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 1739
++ W+ +A+T L D + K++ + +K L + D++ ++++ D NL
Sbjct: 238 LEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDE 297
Query: 1740 N--------RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1791
N G L++ ++ +N +++ + K S+ ++ + +SD K L
Sbjct: 298 NSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR------KKSLNIRSHLEASSDQWKRLH 351
Query: 1792 PLEAEIQQGVNLKEEDFNKD------------MNEDNEGTVKELLQRGDNLQQRITDER- 1838
E+ + LK+++ ++ N+ + +EL + + + R
Sbjct: 352 LSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRI 411
Query: 1839 --KREEIKIKQQLLQTKHNALKDLRSQR-----RKKALEISHQWYQYKRQADDLLKCLDD 1891
+ ++ ++L Q + R+Q RK+A E++ +W + + D + +D+
Sbjct: 412 FLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDE 471
Query: 1892 IEKKLASLPEPRDERKIKEIDRELQK 1917
++L L E DE +K E+ K
Sbjct: 472 TLERLQELQEATDELDLKLRQAEVIK 497
Score = 55.8 bits (133), Expect = 8e-07
Identities = 96/533 (18%), Positives = 216/533 (40%), Gaps = 75/533 (14%)
Query: 1340 LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDA 1399
L FN W EL + LL+Q I+S + L I E + I K
Sbjct: 12 LADFNRAWTELTDWL----SLLDQVIKSQRVMVGDLEDINEMI----------IKQKATM 57
Query: 1400 AQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAA-------QRVLSQIDVAQKKLQDVSM 1452
+ Q +++ +T+ + +K +EA +R+ +Q D Q+ LQ+
Sbjct: 58 QDLEQRRPQLEELITA----AQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQ 113
Query: 1453 KFR-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEV 1511
+ + + + + +E++ +L + + L + + + +Q ++ L K L +
Sbjct: 114 QLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQW 173
Query: 1512 KSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1571
++ V++ ++++ ++ +++ + + + +V+ER+ LE+ +L ++
Sbjct: 174 QTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQ 233
Query: 1572 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG-KATQKEIEKQKVHLKSITEV 1630
++ WL T+ E T + E + G K K+ + + +++ T+V
Sbjct: 234 FPLDLEKFLAWL--TEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDV 291
Query: 1631 --------GEALKTVLGKKE-TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFD 1681
+ L+++ G + L++ +L +N W + ++ + L +
Sbjct: 292 YHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLH 351
Query: 1682 QNVDHITKWIIQADTLLDESEKKKP--------QQKEDVLKRLKAELNDIRPKVDSTRDQ 1733
++ + W+ D DE ++ P Q++ DV + K EL P + ST +
Sbjct: 352 LSLQELLVWLQLKD---DELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET 408
Query: 1734 AANLMANRG-DHCRKLV-EPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1791
+ + + KL EP+ R ++ ++ K+ E+ N++ +KL
Sbjct: 409 VRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR--------KQAEEVNTEWEKL-- 458
Query: 1792 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIK 1844
NL D+ + ++E E ++EL + D L ++ R+ E IK
Sbjct: 459 ----------NLHSADWQRKIDETLE-RLQELQEATDELDLKL---RQAEVIK 497
Score = 49.7 bits (117), Expect = 5e-05
Identities = 91/510 (17%), Positives = 215/510 (42%), Gaps = 53/510 (10%)
Query: 1277 WLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRIL---AQTL---TDGG 1330
WL+ ++ +K+ + G E+I+E++ + M+ E Q+ L AQ L T
Sbjct: 25 WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 84
Query: 1331 VMDELINEELETFNSRWRELHEEAVRRQ----KLLEQSIQSAQETEKSLHLIQESLTFID 1386
+I + +E ++W E+ E R+ ++L+ S Q + E++ ++ ++ ++
Sbjct: 85 EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 144
Query: 1387 K-QLAAYIADKV-----DAAQMPQEAQKIQSDL-TSHEISLEEMKKHNQGKEAAQRVLSQ 1439
+ Y D + + Q+ ++ ++ Q+++ +++++L+ ++ ++ ++++
Sbjct: 145 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE 204
Query: 1440 IDVAQKKLQDVSMKFRLFQKPANFEQR---LQESKMILDEVKMHLPALET------KSVE 1490
A + S+ R+ ++ A E+ LQ+ + L++ L ET +
Sbjct: 205 NINASWR----SIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATR 260
Query: 1491 QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ--------TENPKELDERVT 1542
+E + L K +++ E+E + + Q +++ L R+
Sbjct: 261 KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLD 320
Query: 1543 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1602
+ ++EL K + LE +++ + L WL D EL++++ + G
Sbjct: 321 NMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPA 380
Query: 1603 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKT--VLGKKETLVEDKLSLLNSNWIAVT 1660
+ + +A ++E++ ++ + S E T L E L ++ L
Sbjct: 381 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL------PPE 434
Query: 1661 SRAEEWLNLLLEYQKHMETFDQNVD-HITKWIIQADTLLDESEKKKPQQKEDVLKRLKAE 1719
RA+ LL + + + T + ++ H W + D L+ ++ + E LK +AE
Sbjct: 435 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 494
Query: 1720 L--NDIRP----KVDSTRDQAANLMANRGD 1743
+ +P +DS +D + A RG+
Sbjct: 495 VIKGSWQPVGDLLIDSLQDHLEKVKALRGE 524
Score = 47.4 bits (111), Expect = 3e-04
Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)
Query: 259 EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 318
E H ++H + + Q + +G + + R + + + S RS HL
Sbjct: 286 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 340
Query: 319 EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 378
EA D+ R +L+E+L WL +D L Q I D V+ Q H
Sbjct: 341 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 388
Query: 379 EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 420
+ +L + + + L+ L G KL ++ EE +++Q
Sbjct: 389 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 448
Query: 421 NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 475
+N+ WE L + S + Q + L ++L+EL + + + + R+ E +P+
Sbjct: 449 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 503
Query: 476 GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 531
G L D L+ +++ K L+ + L++ VN L + + + + LE+
Sbjct: 504 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 559
Query: 532 LGDRWANICRWTEDR 546
L RW + EDR
Sbjct: 560 LNTRWKLLQVAVEDR 574
Score = 35.0 bits (79), Expect = 1.4
Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)
Query: 2263 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 2318
L ++ + G L + ISP E E+ L Q Q + L + + I + ++
Sbjct: 971 LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 1029
Query: 2319 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 2378
G+LE+ L DLEE+ +L ++ Q E P ++ T + P E+
Sbjct: 1030 RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 1085
Query: 2379 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 2435
+++ + L + K + + LED + + ++ ++RL Q L Q + TT+ + T
Sbjct: 1086 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 1143
>gi|5032313 dystrophin Dp140bc isoform [Homo sapiens]
Length = 1133
Score = 1908 bits (4943), Expect = 0.0
Identities = 970/1073 (90%), Positives = 988/1073 (92%), Gaps = 52/1073 (4%)
Query: 2457 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2516
MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
Sbjct: 1 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 60
Query: 2517 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2576
EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
Sbjct: 61 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 120
Query: 2577 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2636
DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
Sbjct: 121 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 180
Query: 2637 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2696
NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
Sbjct: 181 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 240
Query: 2697 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2756
FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
Sbjct: 241 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 300
Query: 2757 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2816
KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
Sbjct: 301 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 360
Query: 2817 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 2876
LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
Sbjct: 361 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 420
Query: 2877 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 2936
LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
Sbjct: 421 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 480
Query: 2937 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 2996
EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
Sbjct: 481 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 540
Query: 2997 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 3056
QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
Sbjct: 541 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 600
Query: 3057 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 3116
WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
Sbjct: 601 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 660
Query: 3117 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 3176
LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
Sbjct: 661 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 720
Query: 3177 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 3236
WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
Sbjct: 721 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 780
Query: 3237 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 3296
SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
Sbjct: 781 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 840
Query: 3297 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 3356
VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
Sbjct: 841 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 900
Query: 3357 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDS 3416
TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET +
Sbjct: 901 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETNL---------- 950
Query: 3417 APASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLN 3476
Q +D + EH L+ SP E +
Sbjct: 951 ------QAEYDRLKQQHEHKG-------------LSPLPSPPEMMP-------------- 977
Query: 3477 QDSPLSQPRSPAQILISLES----EERGELERILADLEEENRNLQAEYDRLKQ 3525
+ P+SP + E+ + +G LE + LE+ N+ L+++ RL+Q
Sbjct: 978 -----TSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQ 1025
Score = 306 bits (785), Expect = 2e-82
Identities = 158/164 (96%), Positives = 159/164 (96%), Gaps = 2/164 (1%)
Query: 3509 LEEENR--NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG 3566
LE +N NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG
Sbjct: 941 LEGDNMETNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKG 1000
Query: 3567 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR 3626
RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR
Sbjct: 1001 RLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLR 1060
Query: 3627 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRN 3670
VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRG N
Sbjct: 1061 VVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHN 1104
Score = 100 bits (249), Expect = 3e-20
Identities = 166/775 (21%), Positives = 312/775 (40%), Gaps = 89/775 (11%)
Query: 2001 THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAAL 2059
T ++ L ++Q++ + + D ED+ + K L+Q +++ +I + +
Sbjct: 20 TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 79
Query: 2060 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT-- 2117
+++ R + + + ++ QW++V + ++R+ + + +K QWL
Sbjct: 80 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAK 129
Query: 2118 -EAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTVVRTLNATGEEIIQ 2167
EAEQ L + + E+W+ Y K+L + Q QT V N ++++
Sbjct: 130 EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 189
Query: 2168 QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 2227
S D + ++N W+ + K++S+R+ LEE +L +F DL +F+ WL EA+
Sbjct: 190 DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 249
Query: 2228 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPIS 2280
A++ + ++++L E + VK L+++ QG + L+E +L S S
Sbjct: 250 TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS 309
Query: 2281 PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 2340
++ L+ +L N +W ++ + + +EA +L L++ LL+WL
Sbjct: 310 -DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE-------LLVWL 361
Query: 2341 SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE 2400
E+ Q G F AVQ KQ DV + L ++P +
Sbjct: 362 Q--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVR 410
Query: 2401 DLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQPVVTKETAISKLEM 2457
+E + + +L QE R P+ Q VT L+ + T KL +
Sbjct: 411 IFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQAEEVNTEWEKLNL 460
Query: 2458 PSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL--EDINEMIIKQKA 2511
S+ ++ + + E TD L L +VIK VGDL + + + + K KA
Sbjct: 461 HSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 520
Query: 2512 TMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 2571
++ + + + A+ L + T +E + +W +Q +++R +QL
Sbjct: 521 LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWKLLQVAVEDRVRQL 578
Query: 2572 NEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQKKITETKQLAKDL 2626
+E +D S +L + + K+ + T K+TE Q DL
Sbjct: 579 HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 638
Query: 2627 RQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-ASWRSIHKRVSERE 2677
+ + + L L LL +A D H + +N I ++
Sbjct: 639 NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 698
Query: 2678 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 2732
LE+ H L PL ++ L WL T T + R+L G+ L K
Sbjct: 699 DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFKTGIISLCK 748
Score = 81.3 bits (199), Expect = 2e-14
Identities = 116/572 (20%), Positives = 235/572 (41%), Gaps = 76/572 (13%)
Query: 1056 LKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA 1115
L W++ +D +K + +GD E + + + + + + D++ +P L + Q +KN+
Sbjct: 22 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81
Query: 1116 EPEFASRLETE-LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE 1174
+ A + T+ ++ + QWD + + + R++ L L+ + + E + + QA
Sbjct: 82 SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141
Query: 1175 EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKK 1234
+ T D +QK + E K+ ++ +Q + V + + ++ A + K
Sbjct: 142 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYS--ADDTRKV 199
Query: 1235 ELETLTTNYQW--LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIP 1292
+ T N W + R++ + LEE + LEK WL E E TT N+
Sbjct: 200 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVL 255
Query: 1293 GGA---EEISEVLDSLENLMRHSED---------------NPNQIRILAQTLTDGGVMDE 1334
A E + E ++ LM+ +D + N +IL +G
Sbjct: 256 QDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS--LEGSDDAV 313
Query: 1335 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL-IQESLTFI---DKQLA 1390
L+ L+ N +W EL ++++ + ++++ + K LHL +QE L ++ D +L+
Sbjct: 314 LLQRRLDNMNFKWSELRKKSLN----IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELS 369
Query: 1391 --AYIADKVDAAQMPQEAQK------------IQSDLTSHEISLEEM------KKHNQGK 1430
A I A Q + + I S L + I L E K + + +
Sbjct: 370 RQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPR 429
Query: 1431 E--AAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1487
E +R + + +K+ ++V+ ++ +L A++++++ E+ L E++ L+ K
Sbjct: 430 ELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLK 489
Query: 1488 SVEQEVV---------------QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTE 1532
+ EV+ Q L L ++ +K V V RQ+
Sbjct: 490 LRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL 549
Query: 1533 NPKELDERVTALKLHYNELGAKVTERKQQLEK 1564
+P L + L + L V +R +QL +
Sbjct: 550 SPYNL-STLEDLNTRWKLLQVAVEDRVRQLHE 580
Score = 65.5 bits (158), Expect = 9e-10
Identities = 70/339 (20%), Positives = 133/339 (39%), Gaps = 22/339 (6%)
Query: 328 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 387
SSLM L + A E+ WL + +++Q + D+E + + + M DL
Sbjct: 3 SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQ 62
Query: 388 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 447
+ ++ ++ L +T QE ++ R E ++ E Q +L
Sbjct: 63 RRPQLEELITAAQNL--------KNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 114
Query: 448 LQNQKLKELNDWLTKTEERTR-------KMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQE 499
L N+ LK+ WL EE + K+E GP ++ +++++ + K L +DL Q
Sbjct: 115 L-NEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQW 173
Query: 500 QVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQR 559
Q V+ + + + T + + + W +I + +R L++ Q+
Sbjct: 174 QTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQ 233
Query: 560 LTEEQCLFSAWLSEKEDAVNKIHTTGFK-----DQNEMLSSLQKLAVLKADLEKKKQSMG 614
+ F AWL+E E N + K D + +++ L+ ++E
Sbjct: 234 FPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYH 293
Query: 615 KLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQK 653
L Q +L +L+ + LDN W L +K
Sbjct: 294 NLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKK 332
Score = 65.5 bits (158), Expect = 9e-10
Identities = 85/480 (17%), Positives = 199/480 (41%), Gaps = 57/480 (11%)
Query: 940 YQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTV 999
+ + + W+ + + ++ V D E + + + + +A L++++ L L T
Sbjct: 15 FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAA 74
Query: 1000 KEMSKKAPSEISRKYQSE-FEEIEGRWKKLSSQLVEHCQKLEEQMNK----LRKIQNHIQ 1054
+ + K ++ +R ++ E I+ +W ++ L Q+L E + L + Q
Sbjct: 75 QNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 134
Query: 1055 TLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNE 1114
L + A+++ + +E P D+ ++K++ + + L D++ Q +++ N+ K+ +
Sbjct: 135 VLGQARAKLESW--KEGPYTVDA--IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRD 190
Query: 1115 AEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAE- 1173
+ ++ + +N W + ++V R+ AL+ DL + W+T+AE
Sbjct: 191 YSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAET 250
Query: 1174 -EEYLERDFEYKTPDELQKAVEEMKRAKEEAQ---QKEAKVKLLTESVNSVIAQAPPVAQ 1229
L+ + E K V+E+ + ++ Q + V + + I ++ +
Sbjct: 251 TANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD 310
Query: 1230 EALKKELETLTTNYQWLCTR-----LNGKCKTLEEVWACWH----ELLSYL--------- 1271
+A+ + N++W R + + + W H ELL +L
Sbjct: 311 DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR 370
Query: 1272 -----------EKANKWLNEVEFKLKTTENIPGGAEEISEV------LDSLENLMRHSED 1314
+K N + +LKT E + E + L+ LE L + +
Sbjct: 371 QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE 430
Query: 1315 NPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1374
P + R AQ +T L+ ++ E N+ W +L+ + Q+ ++++++ QE +++
Sbjct: 431 LPPEER--AQNVT------RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEA 482
Score = 62.0 bits (149), Expect = 1e-08
Identities = 104/571 (18%), Positives = 222/571 (38%), Gaps = 46/571 (8%)
Query: 725 TELHSWITRSEAVLQSPEFAIFRKEGNFSDLKE---KVNAIEREKAEKFRKLQDASRSAQ 781
TEL W++ + V++S + G+ D+ E K A ++ ++ +L++ +AQ
Sbjct: 20 TELTDWLSLLDQVIKSQRVMV----GDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 75
Query: 782 ALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQ 840
L + N+ I E++ ++W E + L R L E + + ++ EQ
Sbjct: 76 NLKNKTSNQEART-IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 134
Query: 841 MTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGP 900
+ A L+ P AI+ ++ K L Q ++ ++ L
Sbjct: 135 VLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD 194
Query: 901 MFLDADFVA--FTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKL 958
+ ++ + V RE L+ L ++ + W+ ++ET
Sbjct: 195 DTRKVHMITENINASWRSIHKRVSEREAALEETHRLL--QQFPLDLEKFLAWLTEAETTA 252
Query: 959 SIPQLSVTDYEIMEQRLG------ELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEIS 1011
++ Q + ++E G + Q LQ ++ + L +++ + S+ +
Sbjct: 253 NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDA 312
Query: 1012 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1071
Q + + +W +L + + LE ++ +++ +Q L W+ D L +
Sbjct: 313 VLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQA 372
Query: 1072 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV------------NEGGQKI---KNEAE 1116
P GD ++KQ R +++T +P + S EG +K+ E
Sbjct: 373 PIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELP 432
Query: 1117 PEFASR-----LETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1171
PE ++ L + +E+NT+W+ + + + LE+ LQ+ E+ + Q
Sbjct: 433 PEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQ 492
Query: 1172 AEEEYLERDFEYKTP---DELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA 1228
A E ++ ++ D LQ +E++K + E + V + + + ++
Sbjct: 493 A--EVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLS 550
Query: 1229 QEALKKELETLTTNYQWLCTRLNGKCKTLEE 1259
L LE L T ++ L + + + L E
Sbjct: 551 PYNL-STLEDLNTRWKLLQVAVEDRVRQLHE 580
Score = 60.8 bits (146), Expect = 2e-08
Identities = 74/446 (16%), Positives = 186/446 (41%), Gaps = 40/446 (8%)
Query: 1506 KSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL-DERVTALKLHYNELGAKVTERKQQLEK 1564
+ L + + ++E +I + + K + + + +R+ ++ ++E+ + R+QQL +
Sbjct: 58 QDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNE 117
Query: 1565 CLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 1624
LK S + + + L +L + ++ K K++ + + ++
Sbjct: 118 MLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNV 177
Query: 1625 KSITEVGEALKTVLGKKETLVEDKLSL-LNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 1683
++ L +T ++ +N++W ++ R E L E + ++ F +
Sbjct: 178 DVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 237
Query: 1684 VDHITKWIIQADT----LLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 1739
++ W+ +A+T L D + K++ + +K L + D++ ++++ D NL
Sbjct: 238 LEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDE 297
Query: 1740 N--------RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1791
N G L++ ++ +N +++ + K S+ ++ + +SD K L
Sbjct: 298 NSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR------KKSLNIRSHLEASSDQWKRLH 351
Query: 1792 PLEAEIQQGVNLKEEDFNKD------------MNEDNEGTVKELLQRGDNLQQRITDER- 1838
E+ + LK+++ ++ N+ + +EL + + + R
Sbjct: 352 LSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRI 411
Query: 1839 --KREEIKIKQQLLQTKHNALKDLRSQR-----RKKALEISHQWYQYKRQADDLLKCLDD 1891
+ ++ ++L Q + R+Q RK+A E++ +W + + D + +D+
Sbjct: 412 FLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDE 471
Query: 1892 IEKKLASLPEPRDERKIKEIDRELQK 1917
++L L E DE +K E+ K
Sbjct: 472 TLERLQELQEATDELDLKLRQAEVIK 497
Score = 55.8 bits (133), Expect = 8e-07
Identities = 96/533 (18%), Positives = 216/533 (40%), Gaps = 75/533 (14%)
Query: 1340 LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDA 1399
L FN W EL + LL+Q I+S + L I E + I K
Sbjct: 12 LADFNRAWTELTDWL----SLLDQVIKSQRVMVGDLEDINEMI----------IKQKATM 57
Query: 1400 AQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAA-------QRVLSQIDVAQKKLQDVSM 1452
+ Q +++ +T+ + +K +EA +R+ +Q D Q+ LQ+
Sbjct: 58 QDLEQRRPQLEELITA----AQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQ 113
Query: 1453 KFR-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEV 1511
+ + + + + +E++ +L + + L + + + +Q ++ L K L +
Sbjct: 114 QLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQW 173
Query: 1512 KSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1571
++ V++ ++++ ++ +++ + + + +V+ER+ LE+ +L ++
Sbjct: 174 QTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQ 233
Query: 1572 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG-KATQKEIEKQKVHLKSITEV 1630
++ WL T+ E T + E + G K K+ + + +++ T+V
Sbjct: 234 FPLDLEKFLAWL--TEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDV 291
Query: 1631 --------GEALKTVLGKKE-TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFD 1681
+ L+++ G + L++ +L +N W + ++ + L +
Sbjct: 292 YHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLH 351
Query: 1682 QNVDHITKWIIQADTLLDESEKKKP--------QQKEDVLKRLKAELNDIRPKVDSTRDQ 1733
++ + W+ D DE ++ P Q++ DV + K EL P + ST +
Sbjct: 352 LSLQELLVWLQLKD---DELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET 408
Query: 1734 AANLMANRG-DHCRKLV-EPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1791
+ + + KL EP+ R ++ ++ K+ E+ N++ +KL
Sbjct: 409 VRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR--------KQAEEVNTEWEKL-- 458
Query: 1792 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIK 1844
NL D+ + ++E E ++EL + D L ++ R+ E IK
Sbjct: 459 ----------NLHSADWQRKIDETLE-RLQELQEATDELDLKL---RQAEVIK 497
Score = 49.7 bits (117), Expect = 5e-05
Identities = 91/510 (17%), Positives = 215/510 (42%), Gaps = 53/510 (10%)
Query: 1277 WLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRIL---AQTL---TDGG 1330
WL+ ++ +K+ + G E+I+E++ + M+ E Q+ L AQ L T
Sbjct: 25 WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 84
Query: 1331 VMDELINEELETFNSRWRELHEEAVRRQ----KLLEQSIQSAQETEKSLHLIQESLTFID 1386
+I + +E ++W E+ E R+ ++L+ S Q + E++ ++ ++ ++
Sbjct: 85 EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 144
Query: 1387 K-QLAAYIADKV-----DAAQMPQEAQKIQSDL-TSHEISLEEMKKHNQGKEAAQRVLSQ 1439
+ Y D + + Q+ ++ ++ Q+++ +++++L+ ++ ++ ++++
Sbjct: 145 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE 204
Query: 1440 IDVAQKKLQDVSMKFRLFQKPANFEQR---LQESKMILDEVKMHLPALET------KSVE 1490
A + S+ R+ ++ A E+ LQ+ + L++ L ET +
Sbjct: 205 NINASWR----SIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATR 260
Query: 1491 QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ--------TENPKELDERVT 1542
+E + L K +++ E+E + + Q +++ L R+
Sbjct: 261 KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLD 320
Query: 1543 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1602
+ ++EL K + LE +++ + L WL D EL++++ + G
Sbjct: 321 NMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPA 380
Query: 1603 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKT--VLGKKETLVEDKLSLLNSNWIAVT 1660
+ + +A ++E++ ++ + S E T L E L ++ L
Sbjct: 381 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL------PPE 434
Query: 1661 SRAEEWLNLLLEYQKHMETFDQNVD-HITKWIIQADTLLDESEKKKPQQKEDVLKRLKAE 1719
RA+ LL + + + T + ++ H W + D L+ ++ + E LK +AE
Sbjct: 435 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 494
Query: 1720 L--NDIRP----KVDSTRDQAANLMANRGD 1743
+ +P +DS +D + A RG+
Sbjct: 495 VIKGSWQPVGDLLIDSLQDHLEKVKALRGE 524
Score = 47.4 bits (111), Expect = 3e-04
Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)
Query: 259 EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 318
E H ++H + + Q + +G + + R + + + S RS HL
Sbjct: 286 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 340
Query: 319 EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 378
EA D+ R +L+E+L WL +D L Q I D V+ Q H
Sbjct: 341 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 388
Query: 379 EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 420
+ +L + + + L+ L G KL ++ EE +++Q
Sbjct: 389 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 448
Query: 421 NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 475
+N+ WE L + S + Q + L ++L+EL + + + + R+ E +P+
Sbjct: 449 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 503
Query: 476 GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 531
G L D L+ +++ K L+ + L++ VN L + + + + LE+
Sbjct: 504 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 559
Query: 532 LGDRWANICRWTEDR 546
L RW + EDR
Sbjct: 560 LNTRWKLLQVAVEDR 574
>gi|5032295 dystrophin Dp116 isoform [Homo sapiens]
Length = 956
Score = 1907 bits (4939), Expect = 0.0
Identities = 946/947 (99%), Positives = 947/947 (100%)
Query: 2735 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 2794
+DLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS
Sbjct: 10 KDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 69
Query: 2795 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 2854
HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK
Sbjct: 70 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 129
Query: 2855 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 2914
EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL
Sbjct: 130 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 189
Query: 2915 NLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKV 2974
NLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKV
Sbjct: 190 NLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKV 249
Query: 2975 KALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQL 3034
KALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQL
Sbjct: 250 KALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQL 309
Query: 3035 HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 3094
HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL
Sbjct: 310 HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 369
Query: 3095 NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 3154
NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY
Sbjct: 370 NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 429
Query: 3155 DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYL 3214
DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYL
Sbjct: 430 DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYL 489
Query: 3215 FKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEA 3274
FKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEA
Sbjct: 490 FKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEA 549
Query: 3275 ALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQ 3334
ALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQ
Sbjct: 550 ALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQ 609
Query: 3335 SCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQ 3394
SCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQ
Sbjct: 610 SCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQ 669
Query: 3395 TVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDS 3454
TVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDS
Sbjct: 670 TVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDS 729
Query: 3455 ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENR 3514
ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENR
Sbjct: 730 ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENR 789
Query: 3515 NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQI 3574
NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQI
Sbjct: 790 NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQI 849
Query: 3575 LEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSD 3634
LEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSD
Sbjct: 850 LEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSD 909
Query: 3635 SMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 3681
SMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 910 SMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 956
Score = 67.8 bits (164), Expect = 2e-10
Identities = 53/235 (22%), Positives = 99/235 (42%), Gaps = 33/235 (14%)
Query: 2477 ELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQ-------------- 2522
EL WL L D + Q + GD + + +A ++L+ + P
Sbjct: 87 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 146
Query: 2523 -----LEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKD 2577
LE+L + L + Q ++ + E + +W+++ H + +++++E L+
Sbjct: 147 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 206
Query: 2578 STQWLEAKEEAEQVLGQARAKLESWKE-GPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2636
+ EA +E + L QA SW+ G +D++Q + + K L ++ + NV
Sbjct: 207 LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 266
Query: 2637 NDLALKL------LRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHR 2685
NDLA +L L Y+ E++N W+ + V +R L E HR
Sbjct: 267 NDLARQLTTLGIQLSPYNLSTL-------EDLNTRWKLLQVAVEDRVRQLHEAHR 314
Score = 60.5 bits (145), Expect = 3e-08
Identities = 79/375 (21%), Positives = 152/375 (40%), Gaps = 34/375 (9%)
Query: 2139 WYLKELQDGIGQRQTVVRTLNATGEEIIQQ-SSKTDASILQEKLGSLNLRWQEVCKQLSD 2197
+++K+LQ I V L+ ++I++ DA +LQ +L ++N +W E+ K+ +
Sbjct: 7 YHVKDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 66
Query: 2198 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQV-KLLVEEL 2256
+ LE + L E ++WL+ D+ S G + +K V + EL
Sbjct: 67 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 126
Query: 2257 PLRQGILKQLNETGGPVLVSAPIS-------------PEEQDK-----LENKLKQTNLQW 2298
++ ++ ET L P+ PEE+ + L + ++ N +W
Sbjct: 127 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 186
Query: 2299 IKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP 2358
K++ + Q +I+ ++ L +L++ ++L+ +L + + ++ Q+
Sbjct: 187 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHL 246
Query: 2359 FDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVK-RKLEDLSSEWK----AVNRLL 2413
V+ + + +V + + L P LEDL++ WK AV +
Sbjct: 247 EKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRV 306
Query: 2414 QELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNR 2473
++L D P AS T V P E AIS ++P + E +
Sbjct: 307 RQLHEAHRDFGP------ASQHFLSTSVQGP---WERAISPNKVPYYINHETQTTCWDHP 357
Query: 2474 AWTELTDWLSLLDQV 2488
TEL L+ L+ V
Sbjct: 358 KMTELYQSLADLNNV 372
Score = 56.2 bits (134), Expect = 6e-07
Identities = 62/314 (19%), Positives = 132/314 (42%), Gaps = 33/314 (10%)
Query: 2036 NIKDSLQQSSGRIDIIHSKKTAALQSATPVE----RVKLQEALSQLDFQWEKVNKMYKDR 2091
++KD + D+ H+ + + +E V LQ L ++F+W ++ K +
Sbjct: 8 HVKDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 67
Query: 2092 QGRFDRSVEKWRRFHYDIKIFNQWL-TEAEQFLRKTQI--------PENWEHAKYKWYLK 2142
+ + S ++W+R H ++ WL + ++ R+ I +N H +K LK
Sbjct: 68 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELK 127
Query: 2143 ELQDGIGQRQTVVRTLNATG-----EEIIQ--------QSSKTDASILQEKLGSLNLRWQ 2189
+ I VR E++ Q + ++ +L+++ +N W+
Sbjct: 128 TKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWE 187
Query: 2190 EVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASI--PLEPGKEQQLKEKLE 2247
++ +D +++++E L E Q +E L L +A+ I P+ L++ LE
Sbjct: 188 KLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLE 247
Query: 2248 QVKLLVEEL-PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALP 2306
+VK L E+ PL++ + + + +SP LE+ N +W + A+
Sbjct: 248 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED----LNTRWKLLQVAVE 303
Query: 2307 EKQGEIEAQIKDLG 2320
++ ++ +D G
Sbjct: 304 DRVRQLHEAHRDFG 317
Score = 53.9 bits (128), Expect = 3e-06
Identities = 64/312 (20%), Positives = 130/312 (41%), Gaps = 26/312 (8%)
Query: 1079 ILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAE-PEFASRLETELKELNTQWDHM 1137
+L ++ + L +I+ ++++E QKI E + A L+ L +N +W +
Sbjct: 1 MLHRKTYHVKDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSEL 60
Query: 1138 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1197
++ + L+ ++ L L E+ W+ ++E + +QK + +
Sbjct: 61 RKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHR 120
Query: 1198 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKE---------LETLTTNYQWLCT 1248
K E + KE + E+V + + P E L +E + +T +
Sbjct: 121 AFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAE 180
Query: 1249 RLNGKCKTLEEVWACWH----ELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVL-D 1303
+N + + L A W E L L++ + +E++ KL+ E I G + + ++L D
Sbjct: 181 EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 240
Query: 1304 SLENLMRH----------SEDNPNQIRILAQTLTDGGVMDELIN-EELETFNSRWRELHE 1352
SL++ + ++N + + LA+ LT G+ N LE N+RW+ L
Sbjct: 241 SLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQV 300
Query: 1353 EAVRRQKLLEQS 1364
R + L ++
Sbjct: 301 AVEDRVRQLHEA 312
Score = 50.4 bits (119), Expect = 3e-05
Identities = 38/164 (23%), Positives = 85/164 (51%), Gaps = 6/164 (3%)
Query: 975 LGELQALQSSLQEQQ-SGLYYLSTTVKEMSKKAPSE-ISRKYQSEFEEIEGRWKKLSSQL 1032
+ L+ ++ L EQ GL L +E+ + ++ ++R + + EE+ W+KL+
Sbjct: 134 MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHS 193
Query: 1033 VEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEI--LKKQLKQCRLL 1090
+ +K++E + +L+++Q L + + +V +K W +GD I L+ L++ + L
Sbjct: 194 ADWQRKIDETLERLQELQEATDELDLKLRQAEV-IKGSWQPVGDLLIDSLQDHLEKVKAL 252
Query: 1091 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQW 1134
+I ++ +++ VN+ +++ L T L++LNT+W
Sbjct: 253 RGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST-LEDLNTRW 295
Score = 47.4 bits (111), Expect = 3e-04
Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)
Query: 259 EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 318
E H ++H + + Q + +G + + R + + + S RS HL
Sbjct: 17 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 71
Query: 319 EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 378
EA D+ R +L+E+L WL +D L Q I D V+ Q H
Sbjct: 72 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 119
Query: 379 EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 420
+ +L + + + L+ L G KL ++ EE +++Q
Sbjct: 120 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 179
Query: 421 NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 475
+N+ WE L + S + Q + L ++L+EL + + + + R+ E +P+
Sbjct: 180 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 234
Query: 476 GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 531
G L D L+ +++ K L+ + L++ VN L + + + + LE+
Sbjct: 235 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 290
Query: 532 LGDRWANICRWTEDR 546
L RW + EDR
Sbjct: 291 LNTRWKLLQVAVEDR 305
Score = 42.4 bits (98), Expect = 0.009
Identities = 53/268 (19%), Positives = 109/268 (40%), Gaps = 26/268 (9%)
Query: 1015 QSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPAL 1074
Q + + +W +L + + LE ++ +++ +Q L W+ D L + P
Sbjct: 47 QRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIG 106
Query: 1075 GDSEILKKQLKQCRLLVSDIQTIQPSLNSV------------NEGGQKI---KNEAEPEF 1119
GD ++KQ R +++T +P + S EG +K+ E PE
Sbjct: 107 GDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEE 166
Query: 1120 ASR-----LETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE 1174
++ L + +E+NT+W+ + + + LE+ LQ+ E+ + QA
Sbjct: 167 RAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQA-- 224
Query: 1175 EYLERDFEYKTP---DELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA 1231
E ++ ++ D LQ +E++K + E + V + + + ++
Sbjct: 225 EVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYN 284
Query: 1232 LKKELETLTTNYQWLCTRLNGKCKTLEE 1259
L LE L T ++ L + + + L E
Sbjct: 285 L-STLEDLNTRWKLLQVAVEDRVRQLHE 311
Score = 40.0 bits (92), Expect = 0.043
Identities = 70/329 (21%), Positives = 138/329 (41%), Gaps = 52/329 (15%)
Query: 2624 KDLR-QWQTNVDVANDL---ALKLLRDYS-ADDTRKVHMITENINASWRSIHKRVSEREA 2678
KDL+ + + + DV ++L + K+LR +DD + +N+N W + K+ +
Sbjct: 10 KDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 69
Query: 2679 ALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQ 2738
LE + ++ L L++ L WL + + +R+ + D V++ + +
Sbjct: 70 HLEASSDQWKRLHLSLQELLVWLQLKD------DELSRQAPIGGDFPAVQKQNDVHRAFK 123
Query: 2739 GEIEAHTDVYHNLDENSQKIL--RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN--IRS 2794
E++ V + E + L + LEG + R L E R +++ +R
Sbjct: 124 RELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELP------PEERAQNVTRLLRK 177
Query: 2795 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 2854
E + +W++L+L + W + D+ L R +Q+ D + +LK +
Sbjct: 178 QAEEVNTEWEKLNLHSAD---WQRKIDETLER-------LQELQEATD-----ELDLKLR 222
Query: 2855 E-PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPP-EERAQNVTRLLRK---------- 2902
+ VI + + V L + + LEK+ E+ P +E +V L R+
Sbjct: 223 QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSP 282
Query: 2903 ----QAEEVNTEWEKLNLHSADWQRKIDE 2927
E++NT W+ L + D R++ E
Sbjct: 283 YNLSTLEDLNTRWKLLQVAVEDRVRQLHE 311
Score = 35.0 bits (79), Expect = 1.4
Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)
Query: 2263 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 2318
L ++ + G L + ISP E E+ L Q Q + L + + I + ++
Sbjct: 715 LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 773
Query: 2319 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 2378
G+LE+ L DLEE+ +L ++ Q E P ++ T + P E+
Sbjct: 774 RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 829
Query: 2379 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 2435
+++ + L + K + + LED + + ++ ++RL Q L Q + TT+ + T
Sbjct: 830 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 887
>gi|5032307 dystrophin Dp140c isoform [Homo sapiens]
Length = 1105
Score = 1888 bits (4891), Expect = 0.0
Identities = 947/975 (97%), Positives = 952/975 (97%), Gaps = 4/975 (0%)
Query: 2457 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2516
MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL
Sbjct: 1 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 60
Query: 2517 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2576
EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK
Sbjct: 61 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 120
Query: 2577 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2636
DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA
Sbjct: 121 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 180
Query: 2637 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2696
NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK
Sbjct: 181 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 240
Query: 2697 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2756
FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ
Sbjct: 241 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 300
Query: 2757 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2816
KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW
Sbjct: 301 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 360
Query: 2817 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 2876
LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG
Sbjct: 361 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEG 420
Query: 2877 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 2936
LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ
Sbjct: 421 LEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQ 480
Query: 2937 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 2996
EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR
Sbjct: 481 EATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLAR 540
Query: 2997 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 3056
QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
Sbjct: 541 QLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP 600
Query: 3057 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 3116
WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC
Sbjct: 601 WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALC 660
Query: 3117 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 3176
LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN
Sbjct: 661 LDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLN 720
Query: 3177 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 3236
WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD
Sbjct: 721 WLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHD 780
Query: 3237 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 3296
SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR
Sbjct: 781 SIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHR 840
Query: 3297 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 3356
VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC
Sbjct: 841 VAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYC 900
Query: 3357 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTV-LEGDNMETPVTLINFWPVD 3415
TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQ + E D ++ P+
Sbjct: 901 TPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQNLQAEYDRLKQQHEHKGLSPLP 960
Query: 3416 SAP---ASSPQLSHD 3427
S P +SPQ D
Sbjct: 961 SPPEMMPTSPQSPRD 975
Score = 332 bits (851), Expect = 4e-90
Identities = 167/168 (99%), Positives = 168/168 (100%)
Query: 3514 RNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 3573
+NLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ
Sbjct: 938 QNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQ 997
Query: 3574 ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 3633
ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS
Sbjct: 998 ILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTS 1057
Query: 3634 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 3681
DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM
Sbjct: 1058 DSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM 1105
Score = 100 bits (249), Expect = 3e-20
Identities = 166/775 (21%), Positives = 312/775 (40%), Gaps = 89/775 (11%)
Query: 2001 THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRID-IIHSKKTAAL 2059
T ++ L ++Q++ + + D ED+ + K L+Q +++ +I + +
Sbjct: 20 TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 79
Query: 2060 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT-- 2117
+++ R + + + ++ QW++V + ++R+ + + +K QWL
Sbjct: 80 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEM----------LKDSTQWLEAK 129
Query: 2118 -EAEQFLRKTQIP-ENWEHAKYK--------WYLKELQDGIGQRQTVVRTLNATGEEIIQ 2167
EAEQ L + + E+W+ Y K+L + Q QT V N ++++
Sbjct: 130 EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLR 189
Query: 2168 QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 2227
S D + ++N W+ + K++S+R+ LEE +L +F DL +F+ WL EA+
Sbjct: 190 DYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE 249
Query: 2228 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG-------ILKQLNETGGPVLVSAPIS 2280
A++ + ++++L E + VK L+++ QG + L+E +L S S
Sbjct: 250 TTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGS 309
Query: 2281 PEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWL 2340
++ L+ +L N +W ++ + + +EA +L L++ LL+WL
Sbjct: 310 -DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQE-------LLVWL 361
Query: 2341 SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE 2400
E+ Q G F AVQ KQ DV + L ++P +
Sbjct: 362 Q--LKDDELSRQAPIGGDFP------AVQ-KQNDVHRAFKR--ELKTKEPVIMSTLETVR 410
Query: 2401 DLSSE--WKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT-LVTQPVVTKETAISKLEM 2457
+E + + +L QE R P+ Q VT L+ + T KL +
Sbjct: 411 IFLTEQPLEGLEKLYQEPRELPPE----------ERAQNVTRLLRKQAEEVNTEWEKLNL 460
Query: 2458 PSS-LMLEVPALADFNRAWTELTDWLSL---LDQVIKSQRVMVGDL--EDINEMIIKQKA 2511
S+ ++ + + E TD L L +VIK VGDL + + + + K KA
Sbjct: 461 HSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 520
Query: 2512 TMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 2571
++ + + + A+ L + T +E + +W +Q +++R +QL
Sbjct: 521 LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLST--LEDLNTRWKLLQVAVEDRVRQL 578
Query: 2572 NEMLKD----STQWLEAKEEAEQVLGQARAKLESW-KEGPYTVDAIQKKITETKQLAKDL 2626
+E +D S +L + + K+ + T K+TE Q DL
Sbjct: 579 HEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 638
Query: 2627 RQWQTNV--------DVANDLALKLLRDYSADDTRKVHMITENIN-ASWRSIHKRVSERE 2677
+ + + L L LL +A D H + +N I ++
Sbjct: 639 NNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIY 698
Query: 2678 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMK 2732
LE+ H L PL ++ L WL T T + R+L G+ L K
Sbjct: 699 DRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGR-----TGRIRVLSFKTGIISLCK 748
Score = 81.3 bits (199), Expect = 2e-14
Identities = 116/572 (20%), Positives = 235/572 (41%), Gaps = 76/572 (13%)
Query: 1056 LKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA 1115
L W++ +D +K + +GD E + + + + + + D++ +P L + Q +KN+
Sbjct: 22 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 81
Query: 1116 EPEFASRLETE-LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE 1174
+ A + T+ ++ + QWD + + + R++ L L+ + + E + + QA
Sbjct: 82 SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 141
Query: 1175 EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKK 1234
+ T D +QK + E K+ ++ +Q + V + + ++ A + K
Sbjct: 142 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYS--ADDTRKV 199
Query: 1235 ELETLTTNYQW--LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIP 1292
+ T N W + R++ + LEE + LEK WL E E TT N+
Sbjct: 200 HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVL 255
Query: 1293 GGA---EEISEVLDSLENLMRHSED---------------NPNQIRILAQTLTDGGVMDE 1334
A E + E ++ LM+ +D + N +IL +G
Sbjct: 256 QDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRS--LEGSDDAV 313
Query: 1335 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL-IQESLTFI---DKQLA 1390
L+ L+ N +W EL ++++ + ++++ + K LHL +QE L ++ D +L+
Sbjct: 314 LLQRRLDNMNFKWSELRKKSLN----IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELS 369
Query: 1391 --AYIADKVDAAQMPQEAQK------------IQSDLTSHEISLEEM------KKHNQGK 1430
A I A Q + + I S L + I L E K + + +
Sbjct: 370 RQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPR 429
Query: 1431 E--AAQRVLSQIDVAQKKLQDVSMKF-RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1487
E +R + + +K+ ++V+ ++ +L A++++++ E+ L E++ L+ K
Sbjct: 430 ELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLK 489
Query: 1488 SVEQEVV---------------QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTE 1532
+ EV+ Q L L ++ +K V V RQ+
Sbjct: 490 LRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL 549
Query: 1533 NPKELDERVTALKLHYNELGAKVTERKQQLEK 1564
+P L + L + L V +R +QL +
Sbjct: 550 SPYNL-STLEDLNTRWKLLQVAVEDRVRQLHE 580
Score = 65.5 bits (158), Expect = 9e-10
Identities = 70/339 (20%), Positives = 133/339 (39%), Gaps = 22/339 (6%)
Query: 328 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 387
SSLM L + A E+ WL + +++Q + D+E + + + M DL
Sbjct: 3 SSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQ 62
Query: 388 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 447
+ ++ ++ L +T QE ++ R E ++ E Q +L
Sbjct: 63 RRPQLEELITAAQNL--------KNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 114
Query: 448 LQNQKLKELNDWLTKTEERTR-------KMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQE 499
L N+ LK+ WL EE + K+E GP ++ +++++ + K L +DL Q
Sbjct: 115 L-NEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQW 173
Query: 500 QVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQR 559
Q V+ + + + T + + + W +I + +R L++ Q+
Sbjct: 174 QTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQ 233
Query: 560 LTEEQCLFSAWLSEKEDAVNKIHTTGFK-----DQNEMLSSLQKLAVLKADLEKKKQSMG 614
+ F AWL+E E N + K D + +++ L+ ++E
Sbjct: 234 FPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYH 293
Query: 615 KLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQK 653
L Q +L +L+ + LDN W L +K
Sbjct: 294 NLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKK 332
Score = 65.5 bits (158), Expect = 9e-10
Identities = 85/480 (17%), Positives = 199/480 (41%), Gaps = 57/480 (11%)
Query: 940 YQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTV 999
+ + + W+ + + ++ V D E + + + + +A L++++ L L T
Sbjct: 15 FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAA 74
Query: 1000 KEMSKKAPSEISRKYQSE-FEEIEGRWKKLSSQLVEHCQKLEEQMNK----LRKIQNHIQ 1054
+ + K ++ +R ++ E I+ +W ++ L Q+L E + L + Q
Sbjct: 75 QNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 134
Query: 1055 TLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNE 1114
L + A+++ + +E P D+ ++K++ + + L D++ Q +++ N+ K+ +
Sbjct: 135 VLGQARAKLESW--KEGPYTVDA--IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRD 190
Query: 1115 AEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAE- 1173
+ ++ + +N W + ++V R+ AL+ DL + W+T+AE
Sbjct: 191 YSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAET 250
Query: 1174 -EEYLERDFEYKTPDELQKAVEEMKRAKEEAQ---QKEAKVKLLTESVNSVIAQAPPVAQ 1229
L+ + E K V+E+ + ++ Q + V + + I ++ +
Sbjct: 251 TANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD 310
Query: 1230 EALKKELETLTTNYQWLCTR-----LNGKCKTLEEVWACWH----ELLSYL--------- 1271
+A+ + N++W R + + + W H ELL +L
Sbjct: 311 DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR 370
Query: 1272 -----------EKANKWLNEVEFKLKTTENIPGGAEEISEV------LDSLENLMRHSED 1314
+K N + +LKT E + E + L+ LE L + +
Sbjct: 371 QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE 430
Query: 1315 NPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1374
P + R AQ +T L+ ++ E N+ W +L+ + Q+ ++++++ QE +++
Sbjct: 431 LPPEER--AQNVT------RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEA 482
Score = 62.0 bits (149), Expect = 1e-08
Identities = 104/571 (18%), Positives = 222/571 (38%), Gaps = 46/571 (8%)
Query: 725 TELHSWITRSEAVLQSPEFAIFRKEGNFSDLKE---KVNAIEREKAEKFRKLQDASRSAQ 781
TEL W++ + V++S + G+ D+ E K A ++ ++ +L++ +AQ
Sbjct: 20 TELTDWLSLLDQVIKSQRVMV----GDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 75
Query: 782 ALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQ 840
L + N+ I E++ ++W E + L R L E + + ++ EQ
Sbjct: 76 NLKNKTSNQEART-IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 134
Query: 841 MTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGP 900
+ A L+ P AI+ ++ K L Q ++ ++ L
Sbjct: 135 VLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD 194
Query: 901 MFLDADFVA--FTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKL 958
+ ++ + V RE L+ L ++ + W+ ++ET
Sbjct: 195 DTRKVHMITENINASWRSIHKRVSEREAALEETHRLL--QQFPLDLEKFLAWLTEAETTA 252
Query: 959 SIPQLSVTDYEIMEQRLG------ELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEIS 1011
++ Q + ++E G + Q LQ ++ + L +++ + S+ +
Sbjct: 253 NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDA 312
Query: 1012 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1071
Q + + +W +L + + LE ++ +++ +Q L W+ D L +
Sbjct: 313 VLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQA 372
Query: 1072 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV------------NEGGQKI---KNEAE 1116
P GD ++KQ R +++T +P + S EG +K+ E
Sbjct: 373 PIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELP 432
Query: 1117 PEFASR-----LETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1171
PE ++ L + +E+NT+W+ + + + LE+ LQ+ E+ + Q
Sbjct: 433 PEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQ 492
Query: 1172 AEEEYLERDFEYKTP---DELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA 1228
A E ++ ++ D LQ +E++K + E + V + + + ++
Sbjct: 493 A--EVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLS 550
Query: 1229 QEALKKELETLTTNYQWLCTRLNGKCKTLEE 1259
L LE L T ++ L + + + L E
Sbjct: 551 PYNL-STLEDLNTRWKLLQVAVEDRVRQLHE 580
Score = 60.8 bits (146), Expect = 2e-08
Identities = 74/446 (16%), Positives = 186/446 (41%), Gaps = 40/446 (8%)
Query: 1506 KSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL-DERVTALKLHYNELGAKVTERKQQLEK 1564
+ L + + ++E +I + + K + + + +R+ ++ ++E+ + R+QQL +
Sbjct: 58 QDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNE 117
Query: 1565 CLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHL 1624
LK S + + + L +L + ++ K K++ + + ++
Sbjct: 118 MLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNV 177
Query: 1625 KSITEVGEALKTVLGKKETLVEDKLSL-LNSNWIAVTSRAEEWLNLLLEYQKHMETFDQN 1683
++ L +T ++ +N++W ++ R E L E + ++ F +
Sbjct: 178 DVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 237
Query: 1684 VDHITKWIIQADT----LLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 1739
++ W+ +A+T L D + K++ + +K L + D++ ++++ D NL
Sbjct: 238 LEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDE 297
Query: 1740 N--------RGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1791
N G L++ ++ +N +++ + K S+ ++ + +SD K L
Sbjct: 298 NSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR------KKSLNIRSHLEASSDQWKRLH 351
Query: 1792 PLEAEIQQGVNLKEEDFNKD------------MNEDNEGTVKELLQRGDNLQQRITDER- 1838
E+ + LK+++ ++ N+ + +EL + + + R
Sbjct: 352 LSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRI 411
Query: 1839 --KREEIKIKQQLLQTKHNALKDLRSQR-----RKKALEISHQWYQYKRQADDLLKCLDD 1891
+ ++ ++L Q + R+Q RK+A E++ +W + + D + +D+
Sbjct: 412 FLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDE 471
Query: 1892 IEKKLASLPEPRDERKIKEIDRELQK 1917
++L L E DE +K E+ K
Sbjct: 472 TLERLQELQEATDELDLKLRQAEVIK 497
Score = 55.8 bits (133), Expect = 8e-07
Identities = 96/533 (18%), Positives = 216/533 (40%), Gaps = 75/533 (14%)
Query: 1340 LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDA 1399
L FN W EL + LL+Q I+S + L I E + I K
Sbjct: 12 LADFNRAWTELTDWL----SLLDQVIKSQRVMVGDLEDINEMI----------IKQKATM 57
Query: 1400 AQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAA-------QRVLSQIDVAQKKLQDVSM 1452
+ Q +++ +T+ + +K +EA +R+ +Q D Q+ LQ+
Sbjct: 58 QDLEQRRPQLEELITA----AQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQ 113
Query: 1453 KFR-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEV 1511
+ + + + + +E++ +L + + L + + + +Q ++ L K L +
Sbjct: 114 QLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQW 173
Query: 1512 KSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1571
++ V++ ++++ ++ +++ + + + +V+ER+ LE+ +L ++
Sbjct: 174 QTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQ 233
Query: 1572 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWG-KATQKEIEKQKVHLKSITEV 1630
++ WL T+ E T + E + G K K+ + + +++ T+V
Sbjct: 234 FPLDLEKFLAWL--TEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDV 291
Query: 1631 --------GEALKTVLGKKE-TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFD 1681
+ L+++ G + L++ +L +N W + ++ + L +
Sbjct: 292 YHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLH 351
Query: 1682 QNVDHITKWIIQADTLLDESEKKKP--------QQKEDVLKRLKAELNDIRPKVDSTRDQ 1733
++ + W+ D DE ++ P Q++ DV + K EL P + ST +
Sbjct: 352 LSLQELLVWLQLKD---DELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET 408
Query: 1734 AANLMANRG-DHCRKLV-EPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1791
+ + + KL EP+ R ++ ++ K+ E+ N++ +KL
Sbjct: 409 VRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLR--------KQAEEVNTEWEKL-- 458
Query: 1792 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIK 1844
NL D+ + ++E E ++EL + D L ++ R+ E IK
Sbjct: 459 ----------NLHSADWQRKIDETLE-RLQELQEATDELDLKL---RQAEVIK 497
Score = 49.7 bits (117), Expect = 5e-05
Identities = 91/510 (17%), Positives = 215/510 (42%), Gaps = 53/510 (10%)
Query: 1277 WLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRIL---AQTL---TDGG 1330
WL+ ++ +K+ + G E+I+E++ + M+ E Q+ L AQ L T
Sbjct: 25 WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQ 84
Query: 1331 VMDELINEELETFNSRWRELHEEAVRRQ----KLLEQSIQSAQETEKSLHLIQESLTFID 1386
+I + +E ++W E+ E R+ ++L+ S Q + E++ ++ ++ ++
Sbjct: 85 EARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLE 144
Query: 1387 K-QLAAYIADKV-----DAAQMPQEAQKIQSDL-TSHEISLEEMKKHNQGKEAAQRVLSQ 1439
+ Y D + + Q+ ++ ++ Q+++ +++++L+ ++ ++ ++++
Sbjct: 145 SWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITE 204
Query: 1440 IDVAQKKLQDVSMKFRLFQKPANFEQR---LQESKMILDEVKMHLPALET------KSVE 1490
A + S+ R+ ++ A E+ LQ+ + L++ L ET +
Sbjct: 205 NINASWR----SIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATR 260
Query: 1491 QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ--------TENPKELDERVT 1542
+E + L K +++ E+E + + Q +++ L R+
Sbjct: 261 KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLD 320
Query: 1543 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1602
+ ++EL K + LE +++ + L WL D EL++++ + G
Sbjct: 321 NMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPA 380
Query: 1603 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKT--VLGKKETLVEDKLSLLNSNWIAVT 1660
+ + +A ++E++ ++ + S E T L E L ++ L
Sbjct: 381 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL------PPE 434
Query: 1661 SRAEEWLNLLLEYQKHMETFDQNVD-HITKWIIQADTLLDESEKKKPQQKEDVLKRLKAE 1719
RA+ LL + + + T + ++ H W + D L+ ++ + E LK +AE
Sbjct: 435 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 494
Query: 1720 L--NDIRP----KVDSTRDQAANLMANRGD 1743
+ +P +DS +D + A RG+
Sbjct: 495 VIKGSWQPVGDLLIDSLQDHLEKVKALRGE 524
Score = 47.4 bits (111), Expect = 3e-04
Identities = 68/315 (21%), Positives = 125/315 (39%), Gaps = 53/315 (16%)
Query: 259 EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 318
E H ++H + + Q + +G + + R + + + S RS HL
Sbjct: 286 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS-----HL 340
Query: 319 EAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 378
EA D+ R +L+E+L WL +D L Q I D V+ Q H
Sbjct: 341 EASSDQ------------WKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 388
Query: 379 EGYMMDLTAHQGRVGNILQ------LGSKLIGTGKLSED------EETE------VQEQM 420
+ +L + + + L+ L G KL ++ EE +++Q
Sbjct: 389 RAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQA 448
Query: 421 NLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPL 475
+N+ WE L + S + Q + L ++L+EL + + + + R+ E +P+
Sbjct: 449 EEVNTEWEKLNLHSADWQRKIDETL-----ERLQELQEATDELDLKLRQAEVIKGSWQPV 503
Query: 476 GPDLED-LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 531
G L D L+ +++ K L+ + L++ VN L + + + + LE+
Sbjct: 504 GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---- 559
Query: 532 LGDRWANICRWTEDR 546
L RW + EDR
Sbjct: 560 LNTRWKLLQVAVEDR 574
>gi|110611228 utrophin [Homo sapiens]
Length = 3433
Score = 1744 bits (4517), Expect = 0.0
Identities = 1059/2922 (36%), Positives = 1661/2922 (56%), Gaps = 260/2922 (8%)
Query: 6 SDEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGST 65
SDE DVQKKTFTKW+NA+FSK GK I ++F+DL+DGR+LLDLLEGLTG LPKE+GST
Sbjct: 26 SDEHNDVQKKTFTKWINARFSKSGKPPINDMFTDLKDGRKLLDLLEGLTGTSLPKERGST 85
Query: 66 RVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMA 125
RVHALNNVN+ L+VL NNV+LVNIG TDIVDGNHKLTLGL+W+IILHWQVK+VMK++M+
Sbjct: 86 RVHALNNVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIILHWQVKDVMKDVMS 145
Query: 126 GLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQ 185
LQQTNSEKILLSWVRQ+TR Y QVNV+NFTTSW+DGLA NA++H H+PDLF W+ VV +
Sbjct: 146 DLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDKVV-K 204
Query: 186 QSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQ 245
S +RLEHAF+ A+ LGIEKLLDPEDV PDKKSI+MY+TSLF+VLPQQV+I+AI+
Sbjct: 205 MSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIR 264
Query: 246 EVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTT 305
EVE LPR K EE + I + E SP+
Sbjct: 265 EVETLPRKYKKECEE-----------EAINIQSTAPEEEHESPRA--------------- 298
Query: 306 SDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEIS 365
E P S++ E +++LD YQ ALEEVL+WLLSAEDT Q Q +IS
Sbjct: 299 -------------ETP------STVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDIS 339
Query: 366 NDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNS 425
+DVE VKDQF THE +MM+LTAHQ VG++LQ G++LI G LS++EE E+QEQM LLN+
Sbjct: 340 DDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNA 399
Query: 426 RWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQ 485
RWE LRV SM++QS LH VLM+LQ ++L++L+ WLT TEER +KME PL D++ L++
Sbjct: 400 RWEALRVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKL 459
Query: 486 VQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTED 545
+++HK LQ DLE EQV+VNSLTHMVV+VDE+SG+ ATA LE+QL+ LG+RW +CRWTE+
Sbjct: 460 LEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEE 519
Query: 546 RWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKAD 605
RW LQ+I + WQ L EEQCL AWL+EKE+A+NK+ T+ FKDQ E+ S+++LA+LK D
Sbjct: 520 RWNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKED 579
Query: 606 LEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAV 665
+E K+Q++ +L + QD+ L N ++K + + + WD+LVQ+LE S+ Q++QAV
Sbjct: 580 MEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAV 639
Query: 666 TTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDIT 725
+ ++Q + + TV REQ + K +++ELPPPPP KKRQI VD E +K+ D
Sbjct: 640 --AKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISA 697
Query: 726 ELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVE 785
EL +WI + + +Q+ E + K + S++K+K+ A+E+E+ E+ + + +++ Q LVE
Sbjct: 698 ELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVE 757
Query: 786 QMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTA 845
QM EG+ + IK E+++S W Q L + ++ Q +I A++ QL +LE++ T
Sbjct: 758 QMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTK 817
Query: 846 ENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDA 905
E W+K + S ++ S C+ E+ L GL P+IE + AL + P F+
Sbjct: 818 EEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQR 877
Query: 906 DFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSV 965
F +F ++ V V+ R++ L+ P Y ET+ ++ + SE K + +
Sbjct: 878 GFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVL 937
Query: 966 TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRW 1025
D +E+ L E + L L+ Q+ L+ L+ K + K ++ + Y+ EF++++G+W
Sbjct: 938 NDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKW 997
Query: 1026 KKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLK 1085
KL + + LEE LR + ++KWM V FL ++ A GD L++QL
Sbjct: 998 NKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLD 1057
Query: 1086 QCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARK 1145
QC V++I+TI+ SL ++ E +++ + ++T L + TQ + + +++ +K
Sbjct: 1058 QCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQK 1117
Query: 1146 EALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQ 1205
L EK +L+KDL+EM EWMTQAEEEYLERDFEYK+P+EL+ AVEEMKRAKE+ Q
Sbjct: 1118 SRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQ 1177
Query: 1206 KEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWH 1265
KE +VK+L +++ + A+ P QE L EL + NYQ LC R+ GKC TLEEVW+CW
Sbjct: 1178 KEVRVKILKDNIKLLAAKVPSGGQE-LTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWI 1236
Query: 1266 ELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQT 1325
ELL YL+ WLN +E ++K+TE +P + ++E L+SLE+++RH DN QIR L QT
Sbjct: 1237 ELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQT 1296
Query: 1326 LTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI 1385
L DGG++D++I+E+LE FNSR+ +L A +Q LE+ +Q +ET++ L ++QESL +
Sbjct: 1297 LIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGEL 1356
Query: 1386 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQG------KEAAQRVLSQ 1439
DKQL Y+ D++DA Q+PQEAQKIQ+++++HE++LEE++++ + + R SQ
Sbjct: 1357 DKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQ 1416
Query: 1440 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1499
+DV Q+KL++VS KF+LFQKPANFEQR+ + K +LD VK L L+ K V+ +V+Q+ L+
Sbjct: 1417 MDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLD 1476
Query: 1500 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1559
C+ LYK+LSEVK EVE VIKTGR IVQK+QT+NPK +DE++T+LK+ YN+LGA+VTE K
Sbjct: 1477 KCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGK 1536
Query: 1560 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1619
Q LE+ +L+RKM+KE L+EWL+AT+ EL ++S EG+ +LD+E++W K K++EK
Sbjct: 1537 QDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEK 1596
Query: 1620 QKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMET 1679
+K L +ITE AL+ ++ E ++E++L +LN+ W V + E+W N L+ +Q +E
Sbjct: 1597 RKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEI 1656
Query: 1680 FDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMA 1739
FD NV HI+ W+ QA+ LLDE EKK ++E+++KRL +EL+D +V++ RDQA LM
Sbjct: 1657 FDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMN 1716
Query: 1740 NRGDHCRKLVEPQISELNHRFAAISHRIKTGK-------------------ASIPLKELE 1780
RG R+LVEP+++ELN F +S IK+ K +P +LE
Sbjct: 1717 ARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLE 1776
Query: 1781 QFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKR 1840
+ +DI+ +L+ +E +L+ D ++ M+E++ ++E+LQRG+ + + ++ K+
Sbjct: 1777 KLENDIENMLKFVEK------HLESSDEDEKMDEES-AQIEEVLQRGEEMLHQPMEDNKK 1829
Query: 1841 EEIKIKQQLLQTKHNALKDLRSQRRK-----KALEISHQWYQYKRQADDLLKCLDDIEKK 1895
E+I+++ LL T++N +K + Q+RK + S Y + + +L C+DD+E
Sbjct: 1830 EKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELS 1889
Query: 1896 LASLPEPR---------DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA---AMAVEP 1943
L ++PE E +K I +L K E++ + + + + + A+ +
Sbjct: 1890 L-NVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRD 1948
Query: 1944 TQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHV 2003
T QL+ +W I ++ + + R+ + ++ +
Sbjct: 1949 TLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQ--------------------FHCDLNDL 1988
Query: 2004 SQALLEVEQLLNAPDLCAKDFE-DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 2062
+Q + E E+LL D CA DL K + ++ + ++ +Q
Sbjct: 1989 TQWITEAEELL--VDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKL 2046
Query: 2063 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2122
+ + L+E L+ L+ +W+ + KDRQ R ++ ++ + + WLT+AE
Sbjct: 2047 SQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHA 2106
Query: 2123 LRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKT--DASILQEK 2180
++K E E+ + L++L + ++ LN T E++ S + + + E
Sbjct: 2107 MQKRSTTELGENLQ---ELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISES 2163
Query: 2181 LGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ----RDLNEFVLWLEEAD--------N 2228
L ++N+ W ++C+++ K ++ + +S+ + ++ + VL +D +
Sbjct: 2164 LRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTS 2223
Query: 2229 IASIPLEPGK------------EQQLKEKL------EQVKLLVEELPLRQGILKQLNE-- 2268
SIP + K +Q LK + E++ V + + + L+Q +
Sbjct: 2224 EISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQL 2283
Query: 2269 ----TGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEK 2324
T L + S + + + KL++ QW + +Q ++E I D Q +
Sbjct: 2284 DYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDD 2343
Query: 2325 KLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEG-PFDVQETEIAVQAKQPDVEEILSKGQ 2383
E+ EE + +L I Q ++ + + +I +Q P +++
Sbjct: 2344 HREETEELMR-------KYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDN 2396
Query: 2384 HLYK-----EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTV 2438
L K T+ VK E L + W +N L Q + +Q L T+ AS
Sbjct: 2397 VLQKLLEEYGSDDTRNVKETTEYLKTSW--IN-LKQSIADRQNALEAEWRTVQASRRDLE 2453
Query: 2439 TLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGD 2498
+ + + ET ++ L D + L D S+L + +K Q
Sbjct: 2454 NFL-KWIQEAETTVN-------------VLVDASHRENALQD--SILARELKQQ------ 2491
Query: 2499 LEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWD 2558
++DI I + ++ R Q + N E T++ R++ + +W+
Sbjct: 2492 MQDIQAEIDAHNDIFKSIDGNR----------QKMVKALGNSEEATMLQHRLDDMNQRWN 2541
Query: 2559 E-------VQEHLQNRRQQLNEM---LKDSTQWLEAKEEAEQVLGQARAKLESWKEGPY- 2607
+ ++ HL+ ++ N + L++ +WL K+E E K+ P
Sbjct: 2542 DLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDE------------ELKKQMPIG 2589
Query: 2608 -TVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY----SADDTRKVHMIT--- 2659
V A+Q + K L ++L++ + +V A D A L D + R + T
Sbjct: 2590 GDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELT 2649
Query: 2660 --ENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRK 2717
E +++ K+ SE + E + + + ++K L L + + + L DA K
Sbjct: 2650 PEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDL-DADMK 2708
Query: 2718 ERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDN 2777
E ++ V+ K DL + +L ++ +KI+ E + +++
Sbjct: 2709 E-----AESVRNGWKPVGDL---------LIDSLQDHIEKIMAFREEIAPINFKVKTVND 2754
Query: 2778 MNFKWSEL-RKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQ 2818
++ + S L SL + L+ + +WK L +S+ + L LQ
Sbjct: 2755 LSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQ 2796
Score = 1643 bits (4254), Expect = 0.0
Identities = 1108/3332 (33%), Positives = 1758/3332 (52%), Gaps = 292/3332 (8%)
Query: 436 EKQSNLHRVLMDLQNQK--LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQ 493
E S + V MDL + + L+E+ WL E+ + E++ + D+E++K Q H+
Sbjct: 299 ETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQ--EQDDISDDVEEVKDQFATHEAFM 356
Query: 494 EDLEQEQVRVNSLTHM--VVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQ 551
+L Q V S+ ++ + D ++EQ+ +L RW + + DR L
Sbjct: 357 MELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLH 416
Query: 552 DILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAV----LKADLE 607
D+L++ Q+ +Q SAWL+ E+ + K+ T D + SLQKL L++DLE
Sbjct: 417 DVLMELQKKQLQQ--LSAWLTLTEERIQKMETCPLDDD---VKSLQKLLEEHKSLQSDLE 471
Query: 608 KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 667
++ + L + ++ +S T E L W + + E+ ++ +
Sbjct: 472 AEQVKVNSLTHMVV-IVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINIL 530
Query: 668 TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 727
Q L EQ L+K
Sbjct: 531 WQELL--------------EEQCLLK---------------------------------- 542
Query: 728 HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 787
+W+T E L + + F+ + S ++ ++ + K + L S Q V Q+
Sbjct: 543 -AWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQD-VGQL 600
Query: 788 VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN 847
++ + I SE+L RW Q L + N + + +Q+ Q + + T
Sbjct: 601 LDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGM-SQIPQKDLLETV--- 656
Query: 848 WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 907
R++ Q+I K K + P
Sbjct: 657 -------------------------------------RVREQAITKKSKQELPP------ 673
Query: 908 VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD 967
+Q+ D++A++K FD + E ++ I W +T + + D
Sbjct: 674 -PPPPKKRQIHVDIEAKKK-----FDAISA----ELLNWILKWKTAIQTTEIKEYMKMQD 723
Query: 968 YEIMEQRLGELQALQSSLQEQQSGLYYLSTT----VKEMSKKA-PSEISRKYQSEFEEIE 1022
M+++L +AL+ +E+ L+ T V++M K+ P+E + ++ E++
Sbjct: 724 TSEMKKKL---KALEKEQRERIPRADELNQTGQILVEQMGKEGLPTE---EIKNVLEKVS 777
Query: 1023 GRWKKLSSQL--VEHCQKLEEQMN----KLRKIQNHIQTLKKWMAEVDVF--LKEEWPAL 1074
WK +S L +E +L+E +N +L +++ I+T ++W+ + ++ P+L
Sbjct: 778 SEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSL 837
Query: 1075 GDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNE-AEPEFASRLETELKELNTQ 1133
DS C+ ++++ + P + + ++ + P+F R +
Sbjct: 838 KDS---------CQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQR---GFDSFLGR 885
Query: 1134 WDHMCQQVYARKEALKGGLE--------KTVSLQKDLSEMHEWMTQAEEEYLERDFEYKT 1185
+ + + V R++ L+ L+ +T+ KD+ E Q L
Sbjct: 886 YQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLN------D 939
Query: 1186 PDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQW 1245
+++KA++E K E + ++ + L E ++ P ++ K+E + + +
Sbjct: 940 LAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNK 999
Query: 1246 LCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSL 1305
L ++ LEE+ + KW++ V+ L + G + LD
Sbjct: 1000 LKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQC 1059
Query: 1306 E---NLMRHSEDNPNQIRILAQTLTDGGV--MDELINEELETFNSRWRELHEEAVRRQKL 1360
N + E + ++ + L G V + + L + ++ +L +E ++
Sbjct: 1060 SAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSR 1119
Query: 1361 LEQSIQSAQETEKSLHLIQESLT-----FIDKQLAAYIADKVDAAQMPQEAQKIQSDLTS 1415
L +S + A +K L +QE +T ++++ +++++A +E ++ + D+
Sbjct: 1120 LSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAV--EEMKRAKEDVLQ 1177
Query: 1416 HEISLEEMKKHNQGKEA-----AQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQ-- 1468
E+ ++ +K + + A Q + S+++V + Q + + R K E+
Sbjct: 1178 KEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIR--GKCHTLEEVWSCW 1235
Query: 1469 -ESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEV----KSEVEMVIKTGR 1523
E LD L LE + EV+ + + +SL V + + G+
Sbjct: 1236 IELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQ 1295
Query: 1524 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1583
++ ++ + E++ A Y +L ++ LEK L++ R+ + + VL E L
Sbjct: 1296 TLIDGGILDDI--ISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESL 1353
Query: 1584 AATDMELTK----RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 1639
D +LT R +P A A + +E+ + +++S +T G
Sbjct: 1354 GELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARG 1413
Query: 1640 KKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1699
+ V + S + + + +L+ ++ ++ + + + D +
Sbjct: 1414 GSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVI-- 1471
Query: 1700 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHR 1759
Q D +L L++++ +V++ +++ + K ++ Q++ L
Sbjct: 1472 -------QTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVL 1524
Query: 1760 FAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDF-NKDMNEDNEG 1818
+ + ++ GK ++LE+ S + + ++ A + + ++ E + K +E G
Sbjct: 1525 YNDLGAQVTEGK-----QDLERA-SQLARKMKKEAASLSEWLSATETELVQKSTSEGLLG 1578
Query: 1819 TVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQY 1878
+ + N+ + + E+++ ++ + N ++ ++ ++ W +
Sbjct: 1579 DLDTEISWAKNVLKDL--EKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRV 1636
Query: 1879 KRQADDLLKCLDDIEKKLASLPEP---------RDERKIKEIDRELQKKKEELNAVRRQA 1929
+ +D L + + +L + E + EI+++ K+EE+ V+R
Sbjct: 1637 RTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEI--VKRLV 1694
Query: 1930 EGLSEDGAAMAVEPTQIQL--------SKRWREIESKFAQFRRLNFAQIHTVREETMMVM 1981
L D A + VE + Q S +E K A+ R NF ++ + +++
Sbjct: 1695 SEL--DDANLQVENVRDQALILMNARGSSSRELVEPKLAELNR-NFEKVSQHIKSAKLLI 1751
Query: 1982 TEDMPLEISYVPSTYLTEITHVSQALLE--VEQLLNAPDLCAKDFEDLFKQEESLKNIKD 2039
++ + T+ T + LE +E +L + + ++ K +E I++
Sbjct: 1752 AQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEE 1811
Query: 2040 SLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSV 2099
LQ+ +++H E+++LQ L + K + + + G+ +
Sbjct: 1812 VLQRGE---EMLHQP-----MEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGI 1863
Query: 2100 EKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY------LKELQDGIGQRQT 2153
+ N+ L + +PE A Y+ + LK ++D + +
Sbjct: 1864 RSSLLPTDYLVEINKILLCMDDVELSLNVPE-LNTAIYEDFSFQEDSLKNIKDQLDKLGE 1922
Query: 2154 VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 2213
+ ++ ++I ++S +A +++ L LN +W + + SDRK + +F
Sbjct: 1923 QIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFH 1982
Query: 2214 RDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGP 2272
DLN+ W+ EA+ + PG L K ++ Q +L V + Q LN TG
Sbjct: 1983 CDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVG-ISSHQPSFAALNRTGDG 2041
Query: 2273 VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQ 2332
++ +S + L+ KL N +W + + ++Q ++ + K++ Q
Sbjct: 2042 IVQK--LSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGE-------SKQVMKYRHQ 2092
Query: 2333 LNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI--LSKGQ-HLYKEK 2389
L+ ++ WL+ + ++ + E ++QE Q + E++ L++ + + +K
Sbjct: 2093 LDEIICWLTKAEHAMQ--KRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDK 2150
Query: 2390 PATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKE 2449
+ P + K+ S + VN ++ + P +S +QT + P V K
Sbjct: 2151 SLSLPERDKI---SESLRTVNMTWNKICREVPTTLKECIQEPSSVSQT-RIAAHPNVQKV 2206
Query: 2450 TAISK---LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMI 2506
+S + + S E+ AD ++ TEL DWL L+DQ++KS V VGD+E+IN+ +
Sbjct: 2207 VLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTV 2266
Query: 2507 IKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQN 2566
+ K T DLEQR PQL+ + T AQNLKNK S+ + RT IT+++ER++NQWD Q ++
Sbjct: 2267 SRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVEL 2326
Query: 2567 RRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDL 2626
R+QQL +M+ DS QW + +EE E+++ + A+L ++ D + K+I++ + L ++L
Sbjct: 2327 RQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARR--DPLTKQISDNQILLQEL 2384
Query: 2627 RQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRL 2686
V +++ KLL +Y +DDTR V TE + SW ++ + +++R+ ALE R
Sbjct: 2385 GPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRT 2444
Query: 2687 LQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTD 2746
+Q DLE FL W+ EAETT NVL DA+ +E L+DS +EL +Q QD+Q EI+AH D
Sbjct: 2445 VQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHND 2504
Query: 2747 VYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRL 2806
++ ++D N QK++++L S++A +LQ RLD+MN +W++L+ KS +IR+HLEAS+++W RL
Sbjct: 2505 IFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRL 2564
Query: 2807 HLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVR 2866
+SL+EL+ WL +KD+EL +Q PIGGD PA+Q Q D +A +RELK KE +++ ++ R
Sbjct: 2565 LMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQAR 2624
Query: 2867 IFLTEQPLEGLE---KLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQR 2923
+FL +QP+E E + Q EL PEERAQ + + +RKQ+ EV +WE LN +++WQ+
Sbjct: 2625 VFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQK 2684
Query: 2924 KIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAP 2983
++D+ LE+L++LQ A D+LD +++AE ++ W+PVGDLLIDSLQDH+EK+ A R EIAP
Sbjct: 2685 QVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAP 2744
Query: 2984 LKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGP 3043
+ V VNDL+ QL+ L + S L+DLN RWKLLQV+V+DR++QL EAHRDFGP
Sbjct: 2745 INFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGP 2804
Query: 3044 ASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYR 3103
+SQHFLSTSVQ PW+R+IS NKVPYYINH+TQTTCWDHPKMTEL+QSLADLNNVRFSAYR
Sbjct: 2805 SSQHFLSTSVQLPWQRSISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYR 2864
Query: 3104 TAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNN 3163
TA+K+RRLQKALCLDLL LS + QH L QNDQ + + +INCLTT YD LEQ H +
Sbjct: 2865 TAIKIRRLQKALCLDLLELSTTNEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKD 2924
Query: 3164 LVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTG 3223
LVNVPLCVDMCLNWLLNVYDTGRTG+IRV S K G++SL K LE+KYRYLFK+VA T
Sbjct: 2925 LVNVPLCVDMCLNWLLNVYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTE 2984
Query: 3224 FCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRL 3283
CDQR+LGLLLHD+IQIPRQLGEVA+FGGSNIEPSVRSCFQ NNKPEI F+DWM L
Sbjct: 2985 MCDQRQLGLLLHDAIQIPRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKEFIDWMHL 3044
Query: 3284 EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVA 3343
EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPI+GFRYRSLKHFNYD+CQSCFFSGR A
Sbjct: 3045 EPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIVGFRYRSLKHFNYDVCQSCFFSGRTA 3104
Query: 3344 KGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNME 3403
KGHK+HYPMVEYC PTTSGEDVRDF KVLKNKFR+K+YFAKHPR+GYLPVQTVLEGDN+E
Sbjct: 3105 KGHKLHYPMVEYCIPTTSGEDVRDFTKVLKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLE 3164
Query: 3404 TPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDD 3463
TP+TLI+ WP P+ SPQL HDDTHSRIE YA+RLA+ME +NGS+L DS S S++D
Sbjct: 3165 TPITLISMWPEHYDPSQSPQLFHDDTHSRIEQYATRLAQMERTNGSFLTDSSSTTGSVED 3224
Query: 3464 EHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRL 3523
EH LIQ YCQ+L +SP+SQP+SPAQIL S+E EERGELERI+ADLEEE RNLQ EY++L
Sbjct: 3225 EHALIQQYCQTLGGESPVSQPQSPAQILKSVEREERGELERIIADLEEEQRNLQVEYEQL 3284
Query: 3524 KQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLE 3583
K QH +GL P+ SPPE + + + D+ELIAEAKLLRQHKGRLEARMQILEDHNKQLE
Sbjct: 3285 KDQHLRRGL-PVGSPPESIISPHHTSEDSELIAEAKLLRQHKGRLEARMQILEDHNKQLE 3343
Query: 3584 SQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLS 3643
SQLHRLRQLLEQP++++++NG SP S Q S S + G Q + G EDLL+
Sbjct: 3344 SQLHRLRQLLEQPESDSRINGV---SPWASPQHSALSYSLDPDASGPQFHQAAG-EDLLA 3399
Query: 3644 PPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKP 3675
PP DTST L EVMEQ++++FPS N P +P
Sbjct: 3400 PPHDTSTDLTEVMEQIHSTFPSC-CPNVPSRP 3430
Score = 133 bits (334), Expect = 4e-30
Identities = 244/1185 (20%), Positives = 461/1185 (38%), Gaps = 168/1185 (14%)
Query: 1909 KEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFA 1968
+++ +L KK + + E L + A+ + K +E E + +
Sbjct: 231 EDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINIQSTAPE 290
Query: 1969 QIH-TVREETMMVMTE-DMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE- 2025
+ H + R ET +TE DM L+ +Y + V LL E D + D E
Sbjct: 291 EEHESPRAETPSTVTEVDMDLD------SYQIALEEVLTWLLSAEDTFQEQDDISDDVEE 344
Query: 2026 --DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEK 2083
D F E+ + Q S G + + + + + E ++QE ++ L+ +WE
Sbjct: 345 VKDQFATHEAFMMELTAHQSSVGSV-LQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEA 403
Query: 2084 VNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL-- 2141
+ DRQ R + + ++ ++ + WLT E+ ++K + + K L
Sbjct: 404 LRVESMDRQSRLHDVLMELQK--KQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLE 461
Query: 2142 --KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 2199
K LQ + Q V +L + + S ++ +IL+++L L RW VC+ +R
Sbjct: 462 EHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERW 521
Query: 2200 KRLEEQKNILSEFQRDLNEFVLWL-EEADNIASIPLEPGKEQ-QLKEKLEQVKLLVEELP 2257
RL+E + E + WL E+ + + + K+Q +L + ++ +L E++
Sbjct: 522 NRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDME 581
Query: 2258 LRQGILKQLNETG---GPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 2314
+++ L QL+E G G +L ++ S K+ + ++ +W + + L + ++
Sbjct: 582 MKRQTLDQLSEIGQDVGQLLDNSKAS----KKINSDSEELTQRWDSLVQRLEDSSNQVTQ 637
Query: 2315 QIKDLGQLEKKLEDL--------------------------------------------E 2330
+ LG + +DL
Sbjct: 638 AVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISA 697
Query: 2331 EQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQ----PDVEEILSKGQHLY 2386
E LN +L W + I+ EI + ++++ A++ +Q P +E+ GQ L
Sbjct: 698 ELLNWILKWKTAIQT-TEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILV 756
Query: 2387 ----KEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK---QPDLAPGLTTIGASPTQTVT 2439
KE T+ +K LE +SSEWK V++ L++L K Q D+ +
Sbjct: 757 EQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDE------- 809
Query: 2440 LVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDL 2499
+ + + TKE + + S +P+L D ELT+ L L
Sbjct: 810 -LEKVIKTKEEWVKHTSISESSRQSLPSLKD--SCQRELTNLLGL--------------- 851
Query: 2500 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDE 2559
P++E + L ++ S A + + ++
Sbjct: 852 --------------------HPKIEMARASCSALMSQPS---APDFVQRGFDSFLGRYQA 888
Query: 2560 VQEHLQNRRQQLNEMLKDST--QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKIT 2617
VQE +++R+Q L LK +LE + + VL + K + + ++K +
Sbjct: 889 VQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQ 948
Query: 2618 ETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSERE 2677
E K L + L + + + L ++ D + +++ W + VS
Sbjct: 949 EKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVS--- 1005
Query: 2678 AALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLE-DSKGVKELMKQWQD 2736
++ H LL++ L L F A T E + ++D K++ + D G++ + Q
Sbjct: 1006 ---KDLH-LLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSA 1061
Query: 2737 LQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHL 2796
EIE N+ E + LRS + +Q RL + + +L K+ +S L
Sbjct: 1062 FVNEIETIESSLKNMKE-IETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRL 1120
Query: 2797 EASSDQWKRLHLSLQELLVWL-QLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 2855
S ++ L L E+ W+ Q +++ L R ++ RA K ++ KE
Sbjct: 1121 SESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRA-KEDVLQKE 1179
Query: 2856 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 2915
+ + +++ + P G E + L + N R EEV + W +L
Sbjct: 1180 VRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIEL- 1238
Query: 2916 LHSAD----WQRKIDETLERLQELQEATDELDLKLRQAEVI-------KGSWQPVGDLLI 2964
LH D W ++E ++ + L E TD ++ L E + + + +G LI
Sbjct: 1239 LHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLI 1298
Query: 2965 DS--LQDHL-EKVKALRGEIAPLKENVSHVND-----LARQLTTL 3001
D L D + EK++A E++SH+ + L +QL L
Sbjct: 1299 DGGILDDIISEKLEAFNSRY----EDLSHLAESKQISLEKQLQVL 1339
Score = 102 bits (255), Expect = 5e-21
Identities = 184/915 (20%), Positives = 370/915 (40%), Gaps = 120/915 (13%)
Query: 409 SEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEER 466
S E ++++ + LN++W+ + +++ R + + + + L +L W+T+ EE
Sbjct: 1939 SGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEEL 1998
Query: 467 TRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALE 526
++ G L+ K ++ Q + L+ + Q +L + + + L+
Sbjct: 1999 L--VDTCAPGGSLDLEKARIHQQE-LEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLK 2055
Query: 527 EQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGF 586
E+L L RW I +DR L+ + + + WL++ E A+ K TT
Sbjct: 2056 EKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTT-- 2113
Query: 587 KDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT----QKTEAWLDN 642
E+ +LQ+L L ++E + KL L + L L +KS++ K L
Sbjct: 2114 ----ELGENLQELRDLTQEMEVHAE---KLKWLNRTELEMLSDKSLSLPERDKISESLRT 2166
Query: 643 FARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPP 702
W+ + +++ + + Q + S++QT + ++ +LV A +
Sbjct: 2167 VNMTWNKICREVPTTLKECIQEPS----SVSQTRI---AAHPNVQKVVLVSSASDI---- 2215
Query: 703 PPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAI 762
P Q R T + I LD ITEL W+ + +L+S + G+ ++ + V+ +
Sbjct: 2216 PVQSHR--TSEISIPADLDKTITELADWLVLIDQMLKSNIVTV----GDVEEINKTVSRM 2269
Query: 763 EREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWL 822
+ KA+ ++ L + + N+ ++D +E+L + W
Sbjct: 2270 KITKADLEQRHPQLDY-VFTLAQNLKNKASSSDMRTAITEKLER----------VKNQWD 2318
Query: 823 EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQ 882
Q+ + + QQLE M + W + T +++L I + + P
Sbjct: 2319 GTQHGVEL---RQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQ-----ARRDPL 2370
Query: 883 IERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVF----SDVQAREKEL---------- 928
+++ I L+E G G D +AF N +++ SD KE
Sbjct: 2371 TKQISDNQILLQELGPG----DGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWIN 2426
Query: 929 --QTIFDTLPPMRYQ-ETMSAIRT-------WVQQSETKLSI------PQLSVTDYEIME 972
Q+I D + + T+ A R W+Q++ET +++ + ++ D +
Sbjct: 2427 LKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILAR 2486
Query: 973 QRLGELQALQSSLQEQQSGLYYLSTTVKEMSKK-APSEISRKYQSEFEEIEGRWKKLSSQ 1031
+ ++Q +Q+ + + ++M K SE + Q +++ RW L ++
Sbjct: 2487 ELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAK 2546
Query: 1032 LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLV 1091
LE K ++ ++ L KW+ D LK++ P GD L+ Q C+ L
Sbjct: 2547 SASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALR 2606
Query: 1092 SDIQTIQPS-LNSVNE-----GGQKIKNEAEPEFASRLETEL-----------------K 1128
+++ + S LN+V++ Q I+ EP + +TEL
Sbjct: 2607 RELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSS 2666
Query: 1129 ELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE-EYLERDFEYKTPD 1187
E+ +W+ + ++ + LEK LQ + ++ M +AE + D
Sbjct: 2667 EVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLID 2726
Query: 1188 ELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPV---AQEALKKELETLTTNYQ 1244
LQ +E++ +EE KVK +VN + +Q P+ + ++L+ L ++
Sbjct: 2727 SLQDHIEKIMAFREEIAPINFKVK----TVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWK 2782
Query: 1245 WLCTRLNGKCKTLEE 1259
L ++ + K L+E
Sbjct: 2783 LLQVSVDDRLKQLQE 2797
Score = 70.9 bits (172), Expect = 2e-11
Identities = 80/381 (20%), Positives = 155/381 (40%), Gaps = 47/381 (12%)
Query: 2674 SEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQ 2733
+E + + E L + + LE+ L WL AE T D + +D + VK+
Sbjct: 298 AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDIS------DDVEEVKDQFAT 351
Query: 2734 WQDLQGEIEAH-TDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNI 2792
+ E+ AH + V L +Q I + ++ +Q ++ +N +W LR +S++
Sbjct: 352 HEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDR 411
Query: 2793 RSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ--APIGGDFPAVQKQNDVHRAFKRE 2850
+S L + ++ L Q+L WL L ++ + + P+ D ++QK + H++ + +
Sbjct: 412 QSRLHDVLMELQKKQL--QQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSD 469
Query: 2851 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2910
L+ ++ + S V I E ++ T +L Q +++
Sbjct: 470 LEAEQVKVNSLTHMVVIV--------------------DENSGESATAILEDQLQKLGER 509
Query: 2911 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2970
W + + + ++ E QEL E L L + E + + + + +D
Sbjct: 510 WTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE------EALNKVQTSNFKDQ 563
Query: 2971 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQL---------SPYNLSTLEDLNTRWK 3021
E ++R +A LKE++ QL+ +G + S S E+L RW
Sbjct: 564 KELSVSVR-RLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWD 622
Query: 3022 LLQVAVEDRVRQLHEAHRDFG 3042
L +ED Q+ +A G
Sbjct: 623 SLVQRLEDSSNQVTQAVAKLG 643
Score = 38.9 bits (89), Expect = 0.095
Identities = 50/258 (19%), Positives = 101/258 (39%), Gaps = 39/258 (15%)
Query: 325 SFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD 384
S + L S +R +LEE++ WL ++ L+ Q I DV ++ Q+ + +
Sbjct: 2549 SIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRE 2608
Query: 385 LTAHQGRVGNILQLGSKLIGTGKLSEDEETE---------------------VQEQMNLL 423
L + V N + + + EE +++Q + +
Sbjct: 2609 LKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEV 2668
Query: 424 NSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE-----EPLGPD 478
+WE L + Q + + L +KL++L + + ++ E +P+G
Sbjct: 2669 KEKWESLNAVTSNWQKQVDKAL-----EKLRDLQGAMDDLDADMKEAESVRNGWKPVGDL 2723
Query: 479 LED-LKRQVQQHKVLQEDLEQEQVR---VNSLTHMVVVVDESSGDHATAALEEQLKVLGD 534
L D L+ +++ +E++ + VN L+ + +D H + + QL L
Sbjct: 2724 LIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDL----HPSLKMSRQLDDLNM 2779
Query: 535 RWANICRWTEDRWVLLQD 552
RW + +DR LQ+
Sbjct: 2780 RWKLLQVSVDDRLKQLQE 2797
Score = 34.3 bits (77), Expect = 2.3
Identities = 42/192 (21%), Positives = 74/192 (38%), Gaps = 15/192 (7%)
Query: 2850 ELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE--ERAQNVTRLLRKQAEEV 2907
+L K+ +IM + + ++ + ++ PR+ E E A N+ Q+
Sbjct: 236 QLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINI------QSTAP 289
Query: 2908 NTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSL 2967
E E + ++D L+ Q A +E+ L AE + D ++ +
Sbjct: 290 EEEHESPRAETPSTVTEVDMDLD---SYQIALEEVLTWLLSAEDTFQEQDDISDD-VEEV 345
Query: 2968 QDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED---LNTRWKLLQ 3024
+D +A E+ + +V V QL T G E LN RW+ L+
Sbjct: 346 KDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALR 405
Query: 3025 VAVEDRVRQLHE 3036
V DR +LH+
Sbjct: 406 VESMDRQSRLHD 417
>gi|5032297 dystrophin Dp71 isoform [Homo sapiens]
Length = 617
Score = 1240 bits (3208), Expect = 0.0
Identities = 610/610 (100%), Positives = 610/610 (100%)
Query: 3072 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 3131
HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ
Sbjct: 8 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67
Query: 3132 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 3191
HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR
Sbjct: 68 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127
Query: 3192 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 3251
VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG
Sbjct: 128 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187
Query: 3252 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 3311
GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247
Query: 3312 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 3371
CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV
Sbjct: 248 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307
Query: 3372 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 3431
LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS
Sbjct: 308 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 367
Query: 3432 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 3491
RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL
Sbjct: 368 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 427
Query: 3492 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 3551
ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD
Sbjct: 428 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 487
Query: 3552 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 3611
AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS
Sbjct: 488 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 547
Query: 3612 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT 3671
TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT
Sbjct: 548 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT 607
Query: 3672 PGKPMREDTM 3681
PGKPMREDTM
Sbjct: 608 PGKPMREDTM 617
Score = 35.0 bits (79), Expect = 1.4
Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)
Query: 2263 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 2318
L ++ + G L + ISP E E+ L Q Q + L + + I + ++
Sbjct: 376 LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 434
Query: 2319 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 2378
G+LE+ L DLEE+ +L ++ Q E P ++ T + P E+
Sbjct: 435 RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 490
Query: 2379 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 2435
+++ + L + K + + LED + + ++ ++RL Q L Q + TT+ + T
Sbjct: 491 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 548
>gi|5032299 dystrophin Dp71b isoform [Homo sapiens]
Length = 635
Score = 1214 bits (3142), Expect = 0.0
Identities = 598/599 (99%), Positives = 598/599 (99%)
Query: 3072 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 3131
HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ
Sbjct: 8 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67
Query: 3132 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 3191
HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR
Sbjct: 68 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127
Query: 3192 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 3251
VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG
Sbjct: 128 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187
Query: 3252 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 3311
GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247
Query: 3312 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 3371
CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV
Sbjct: 248 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307
Query: 3372 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 3431
LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS
Sbjct: 308 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 367
Query: 3432 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 3491
RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL
Sbjct: 368 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 427
Query: 3492 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 3551
ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD
Sbjct: 428 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 487
Query: 3552 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 3611
AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS
Sbjct: 488 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 547
Query: 3612 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRN 3670
TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRG N
Sbjct: 548 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHN 606
Score = 35.0 bits (79), Expect = 1.4
Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)
Query: 2263 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 2318
L ++ + G L + ISP E E+ L Q Q + L + + I + ++
Sbjct: 376 LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 434
Query: 2319 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 2378
G+LE+ L DLEE+ +L ++ Q E P ++ T + P E+
Sbjct: 435 RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 490
Query: 2379 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 2435
+++ + L + K + + LED + + ++ ++RL Q L Q + TT+ + T
Sbjct: 491 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 548
>gi|5032301 dystrophin Dp71a isoform [Homo sapiens]
Length = 604
Score = 1203 bits (3112), Expect = 0.0
Identities = 597/610 (97%), Positives = 597/610 (97%), Gaps = 13/610 (2%)
Query: 3072 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 3131
HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ
Sbjct: 8 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67
Query: 3132 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 3191
HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR
Sbjct: 68 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127
Query: 3192 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 3251
VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG
Sbjct: 128 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187
Query: 3252 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 3311
GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247
Query: 3312 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 3371
CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV
Sbjct: 248 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307
Query: 3372 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 3431
LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET PASSPQLSHDDTHS
Sbjct: 308 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET-------------PASSPQLSHDDTHS 354
Query: 3432 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 3491
RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL
Sbjct: 355 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 414
Query: 3492 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 3551
ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD
Sbjct: 415 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 474
Query: 3552 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 3611
AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS
Sbjct: 475 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 534
Query: 3612 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT 3671
TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT
Sbjct: 535 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNT 594
Query: 3672 PGKPMREDTM 3681
PGKPMREDTM
Sbjct: 595 PGKPMREDTM 604
Score = 35.0 bits (79), Expect = 1.4
Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)
Query: 2263 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 2318
L ++ + G L + ISP E E+ L Q Q + L + + I + ++
Sbjct: 363 LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 421
Query: 2319 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 2378
G+LE+ L DLEE+ +L ++ Q E P ++ T + P E+
Sbjct: 422 RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 477
Query: 2379 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 2435
+++ + L + K + + LED + + ++ ++RL Q L Q + TT+ + T
Sbjct: 478 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 535
>gi|5032303 dystrophin Dp71ab isoform [Homo sapiens]
Length = 622
Score = 1177 bits (3046), Expect = 0.0
Identities = 585/599 (97%), Positives = 585/599 (97%), Gaps = 13/599 (2%)
Query: 3072 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 3131
HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ
Sbjct: 8 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67
Query: 3132 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 3191
HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR
Sbjct: 68 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127
Query: 3192 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 3251
VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG
Sbjct: 128 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187
Query: 3252 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 3311
GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247
Query: 3312 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 3371
CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV
Sbjct: 248 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307
Query: 3372 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHS 3431
LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET PASSPQLSHDDTHS
Sbjct: 308 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET-------------PASSPQLSHDDTHS 354
Query: 3432 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 3491
RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL
Sbjct: 355 RIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQIL 414
Query: 3492 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 3551
ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD
Sbjct: 415 ISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRD 474
Query: 3552 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 3611
AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS
Sbjct: 475 AELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPS 534
Query: 3612 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRN 3670
TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRG N
Sbjct: 535 TSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHN 593
Score = 35.0 bits (79), Expect = 1.4
Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 10/178 (5%)
Query: 2263 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE----IEAQIKD 2318
L ++ + G L + ISP E E+ L Q Q + L + + I + ++
Sbjct: 363 LAEMENSNGSYLNDS-ISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEE 421
Query: 2319 LGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEI 2378
G+LE+ L DLEE+ +L ++ Q E P ++ T + P E+
Sbjct: 422 RGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPT----SPQSPRDAEL 477
Query: 2379 LSKGQHLYKEKPATQPVKRKLEDLSSEWKA-VNRLLQELRAKQPDLAPGLTTIGASPT 2435
+++ + L + K + + LED + + ++ ++RL Q L Q + TT+ + T
Sbjct: 478 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPST 535
>gi|148539558 dystrophin related protein 2 [Homo sapiens]
Length = 957
Score = 996 bits (2574), Expect = 0.0
Identities = 494/892 (55%), Positives = 651/892 (72%), Gaps = 27/892 (3%)
Query: 2778 MNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAV 2837
MN W+E++KKS N+R+ LEA SD +L L LQE++ WL KD+ELS Q P+ GD V
Sbjct: 79 MNLCWNEIKKKSHNLRARLEAFSDHSGKLQLPLQEIIDWLSQKDEELSAQLPLQGDVALV 138
Query: 2838 QKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 2897
Q++ + H AF E+K++ P I S LE+ + FL++ P E LE+ + E ++ P++R QN++
Sbjct: 139 QQEKETHAAFMEEVKSRGPYIYSVLESAQAFLSQHPFEELEEPHSESKDTSPKQRIQNLS 198
Query: 2898 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 2957
R + KQA + WEKL D R I+ TLE+L E+Q A +EL L QAE ++ +W+
Sbjct: 199 RFVWKQATVASELWEKLTARCVDQHRHIERTLEQLLEIQGAMEELSTTLSQAEGVRATWE 258
Query: 2958 PVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLN 3017
P+GDL IDSL +H++ +K + E +P+K+ V VNDLA QL + LS N LE +N
Sbjct: 259 PIGDLFIDSLPEHIQAIKLFKEEFSPMKDGVKLVNDLAHQLAISDVHLSMENSQALEQIN 318
Query: 3018 TRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTT 3077
RWK LQ +V +R++QL +AHRDFGP SQHFLS+SVQ PWERAISPNKVPYYINH+ QTT
Sbjct: 319 VRWKQLQASVSERLKQLQDAHRDFGPGSQHFLSSSVQVPWERAISPNKVPYYINHQAQTT 378
Query: 3078 CWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQN 3137
CWDHPKMTELYQ+LADLNN++FSAYRTAMKLRR+QKAL LDL++L+ A + ++H+L+ +
Sbjct: 379 CWDHPKMTELYQTLADLNNIKFSAYRTAMKLRRVQKALRLDLVTLTTALEIFNEHDLQAS 438
Query: 3138 DQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKT 3197
+ MD++++I+CLT +Y+RLE+E LVNVPLCVDM LNWLLNV+D+GR+G++R LSFKT
Sbjct: 439 EHVMDVVEVIHCLTALYERLEEERGILVNVPLCVDMSLNWLLNVFDSGRSGKMRALSFKT 498
Query: 3198 GIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEP 3257
GI LC +++K +YLF QVA+S CDQR LG+LLH++IQ+PRQLGEVA+FGGSN+EP
Sbjct: 499 GIACLCGTEVKEKLQYLFSQVANSGSQCDQRHLGVLLHEAIQVPRQLGEVAAFGGSNVEP 558
Query: 3258 SVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPI 3317
SVRSCF+F+ KP IEA+ FL+W+ LEPQSMVWL VLHRV AE KHQ KC+IC++CPI
Sbjct: 559 SVRSCFRFSTGKPVIEASQFLEWVNLEPQSMVWLAVLHRVTIAEQVKHQTKCSICRQCPI 618
Query: 3318 IGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFR 3377
GFRYRSLK FN DICQ+CF +GR +KG+K+HYP++EY TPTTS E++RDFA LKNKFR
Sbjct: 619 KGFRYRSLKQFNVDICQTCFLTGRASKGNKLHYPIMEYYTPTTSSENMRDFATTLKNKFR 678
Query: 3378 TKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYA 3437
+K YF+KHP+ GYLPVQ+VLE D ET PASSP H DTHSRIEH+A
Sbjct: 679 SKHYFSKHPQRGYLPVQSVLEADYSET-------------PASSPMWPHADTHSRIEHFA 725
Query: 3438 SRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLS--QPRSPAQILISLE 3495
SRLAEME+ N S+ NDS+SP++SID++ L++H SP++ +P Q S+
Sbjct: 726 SRLAEMESQNCSFFNDSLSPDDSIDEDQYLLRH-------SSPITDREPAFGQQAPCSVA 778
Query: 3496 SEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELI 3555
+E +GEL++ILA LE+ENR LQ E RLK QHE + PS + + R+ EL+
Sbjct: 779 TESKGELQKILAHLEDENRILQGELRRLKWQHEE--AAEAPSLADGSTEAATDHRNEELL 836
Query: 3556 AEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQ 3615
AEA++LRQHK RLE RMQILEDHNKQLESQL RLR+LL QP E+ +G+ SS ++S Q
Sbjct: 837 AEARILRQHKSRLETRMQILEDHNKQLESQLQRLRELLLQPPTESDGSGSAGSSLASSPQ 896
Query: 3616 RSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSR 3667
+S+ S P R G T D+ +D+ S QD S LE++ME+L ++FPS R
Sbjct: 897 QSEGSHP---REKGQTTPDTEAADDVGSKSQDVSLCLEDIMEKLRHAFPSVR 945
Score = 65.9 bits (159), Expect = 7e-10
Identities = 54/235 (22%), Positives = 101/235 (42%), Gaps = 33/235 (14%)
Query: 2477 ELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNK 2536
E+ DWLS D+ + +Q + GD+ + + A M++++ R P + ++ +AQ ++
Sbjct: 113 EIIDWLSQKDEELSAQLPLQGDVALVQQEKETHAAFMEEVKSRGPYIYSVLESAQAFLSQ 172
Query: 2537 TSNQE-----ARTIITDRIERIQN--------------QWDEVQEHLQNRRQQLNEMLKD 2577
+E + + T +RIQN W+++ ++ + + L+
Sbjct: 173 HPFEELEEPHSESKDTSPKQRIQNLSRFVWKQATVASELWEKLTARCVDQHRHIERTLEQ 232
Query: 2578 STQWLEAKEEAEQVLGQARAKLESWKE-GPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2636
+ A EE L QA +W+ G +D++ + I K ++ + V +
Sbjct: 233 LLEIQGAMEELSTTLSQAEGVRATWEPIGDLFIDSLPEHIQAIKLFKEEFSPMKDGVKLV 292
Query: 2637 NDLALKLLRDYSADDTRKVHMITEN------INASWRSIHKRVSEREAALEETHR 2685
NDLA +L VH+ EN IN W+ + VSER L++ HR
Sbjct: 293 NDLAHQLA-------ISDVHLSMENSQALEQINVRWKQLQASVSERLKQLQDAHR 340
Score = 57.0 bits (136), Expect = 3e-07
Identities = 51/238 (21%), Positives = 103/238 (43%), Gaps = 30/238 (12%)
Query: 339 RYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQL 398
+ Q L+E++ WL ++ L AQ + DV +V+ + TH +M ++ + + ++L+
Sbjct: 106 KLQLPLQEIIDWLSQKDEELSAQLPLQGDVALVQQEKETHAAFMEEVKSRGPYIYSVLES 165
Query: 399 GSKLIGTGKLSEDEETE------------------VQEQMNLLNSRWECLRVASMEKQSN 440
+ E EE V +Q + + WE L +++ +
Sbjct: 166 AQAFLSQHPFEELEEPHSESKDTSPKQRIQNLSRFVWKQATVASELWEKLTARCVDQHRH 225
Query: 441 LHRVLMDLQNQK--LKELNDWLTKTEERTRKMEEEPLGP-DLEDLKRQVQQHKVLQEDLE 497
+ R L L + ++EL+ L++ E + EP+G ++ L +Q K+ +E+
Sbjct: 226 IERTLEQLLEIQGAMEELSTTLSQAE--GVRATWEPIGDLFIDSLPEHIQAIKLFKEEFS 283
Query: 498 --QEQVR-VNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQD 552
++ V+ VN L H + + D H + + L+ + RW + +R LQD
Sbjct: 284 PMKDGVKLVNDLAHQLAISDV----HLSMENSQALEQINVRWKQLQASVSERLKQLQD 337
Score = 43.5 bits (101), Expect = 0.004
Identities = 72/339 (21%), Positives = 132/339 (38%), Gaps = 51/339 (15%)
Query: 2183 SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQ 2240
++NL W E+ K+ + + RLE + + Q L E + WL + D A +PL+ G
Sbjct: 78 AMNLCWNEIKKKSHNLRARLEAFSDHSGKLQLPLQEIIDWLSQKDEELSAQLPLQ-GDVA 136
Query: 2241 QLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENK---------- 2290
++++ E +EE+ R + + E+ L P E+ E+K
Sbjct: 137 LVQQEKETHAAFMEEVKSRGPYIYSVLESAQAFLSQHPFEELEEPHSESKDTSPKQRIQN 196
Query: 2291 -----LKQTNLQ---WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHL----LL 2338
KQ + W K++ ++ IE ++ L +++ +E+L L+
Sbjct: 197 LSRFVWKQATVASELWEKLTARCVDQHRHIERTLEQLLEIQGAMEELSTTLSQAEGVRAT 256
Query: 2339 WLSPIRNQLEIYNQPNQEGPFDVQETEIA-----VQAKQPDVEEILSKGQHLYKEKPATQ 2393
W PI L I + P + + E + V+ ++ HL E
Sbjct: 257 W-EPI-GDLFIDSLPEHIQAIKLFKEEFSPMKDGVKLVNDLAHQLAISDVHLSMEN---- 310
Query: 2394 PVKRKLEDLSSEWK----AVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKE 2449
+ LE ++ WK +V+ L++L+ D PG +S Q V E
Sbjct: 311 --SQALEQINVRWKQLQASVSERLKQLQDAHRDFGPGSQHFLSSSVQ---------VPWE 359
Query: 2450 TAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQV 2488
AIS ++P + + + TEL L+ L+ +
Sbjct: 360 RAISPNKVPYYINHQAQTTCWDHPKMTELYQTLADLNNI 398
Score = 43.5 bits (101), Expect = 0.004
Identities = 60/257 (23%), Positives = 101/257 (39%), Gaps = 48/257 (18%)
Query: 602 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQI 661
L+A LE GKL Q+++ L K + L LVQ+ +++ A
Sbjct: 93 LRARLEAFSDHSGKLQLPLQEIIDWLSQKDEELSAQLPLQGDVA----LVQQEKETHAAF 148
Query: 662 SQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKK-------------- 707
+ V + P + +V+E+ + L +H EEL P + K
Sbjct: 149 MEEVKSRGPYIY--SVLESA------QAFLSQHPFEELEEPHSESKDTSPKQRIQNLSRF 200
Query: 708 --RQITVDSEIRKRLDVDITELHSWITRS-------EAVLQSPEFAIFRKEGN------- 751
+Q TV SE+ ++L + H I R+ + ++ + + EG
Sbjct: 201 VWKQATVASELWEKLTARCVDQHRHIERTLEQLLEIQGAMEELSTTLSQAEGVRATWEPI 260
Query: 752 ----FSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNAD-SIKQASEQLNS 806
L E + AI+ K E+F ++D + L Q+ V+ QA EQ+N
Sbjct: 261 GDLFIDSLPEHIQAIKLFK-EEFSPMKDGVKLVNDLAHQLAISDVHLSMENSQALEQINV 319
Query: 807 RWIEFCQLLSERLNWLE 823
RW + +SERL L+
Sbjct: 320 RWKQLQASVSERLKQLQ 336
Score = 41.6 bits (96), Expect = 0.015
Identities = 43/256 (16%), Positives = 106/256 (41%), Gaps = 22/256 (8%)
Query: 1025 WKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQL 1084
W ++ + +LE + K+Q +Q + W+++ D L + P GD +++++
Sbjct: 83 WNEIKKKSHNLRARLEAFSDHSGKLQLPLQEIIDWLSQKDEELSAQLPLQGDVALVQQEK 142
Query: 1085 KQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQ----------- 1133
+ + ++++ P + SV E Q ++ E +E K+ + +
Sbjct: 143 ETHAAFMEEVKSRGPYIYSVLESAQAFLSQHPFEELEEPHSESKDTSPKQRIQNLSRFVW 202
Query: 1134 ---------WDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAE-EEYLERDFEY 1183
W+ + + + ++ LE+ + +Q + E+ ++QAE
Sbjct: 203 KQATVASELWEKLTARCVDQHRHIERTLEQLLEIQGAMEELSTTLSQAEGVRATWEPIGD 262
Query: 1184 KTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNY 1243
D L + ++ +K KEE + VKL+ + + + ++ E + LE + +
Sbjct: 263 LFIDSLPEHIQAIKLFKEEFSPMKDGVKLVNDLAHQLAISDVHLSMEN-SQALEQINVRW 321
Query: 1244 QWLCTRLNGKCKTLEE 1259
+ L ++ + K L++
Sbjct: 322 KQLQASVSERLKQLQD 337
Score = 37.0 bits (84), Expect = 0.36
Identities = 35/174 (20%), Positives = 77/174 (44%), Gaps = 14/174 (8%)
Query: 1543 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1602
A+ L +NE+ K + +LE S K++ + + +WL+ D EL+ + ++G +
Sbjct: 78 AMNLCWNEIKKKSHNLRARLEAFSDHSGKLQLPLQEIIDWLSQKDEELSAQLPLQGDVAL 137
Query: 1603 LDSEVAWGKATQKEIEKQKVHLKSITEVGEAL----------KTVLGKKETLVEDKL-SL 1651
+ E A +E++ + ++ S+ E +A + K+T + ++ +L
Sbjct: 138 VQQEKETHAAFMEEVKSRGPYIYSVLESAQAFLSQHPFEELEEPHSESKDTSPKQRIQNL 197
Query: 1652 LNSNWIAVTSRAEEWLNL---LLEYQKHMETFDQNVDHITKWIIQADTLLDESE 1702
W T +E W L ++ +H+E + + I + + T L ++E
Sbjct: 198 SRFVWKQATVASELWEKLTARCVDQHRHIERTLEQLLEIQGAMEELSTTLSQAE 251
Score = 35.4 bits (80), Expect = 1.1
Identities = 54/267 (20%), Positives = 108/267 (40%), Gaps = 39/267 (14%)
Query: 1130 LNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDEL 1189
+N W+ + ++ + + L+ + + LQ L E+ +W++Q +EE L + L
Sbjct: 79 MNLCWNEIKKKSHNLRARLEAFSDHSGKLQLPLQEIIDWLSQKDEE-LSAQLPLQGDVAL 137
Query: 1190 QKAVEEMKRA-KEEAQQKEAKVKLLTESVNSVIAQAP--------PVAQEALKKELETLT 1240
+ +E A EE + + + + ES + ++Q P +++ K+
Sbjct: 138 VQQEKETHAAFMEEVKSRGPYIYSVLESAQAFLSQHPFEELEEPHSESKDTSPKQRIQNL 197
Query: 1241 TNYQW--------LCTRLNGKC--------KTLEEVWACWHELLSYLEKANKWLNEVEFK 1284
+ + W L +L +C +TLE++ E+ +E+ + L++ E
Sbjct: 198 SRFVWKQATVASELWEKLTARCVDQHRHIERTLEQLL----EIQGAMEELSTTLSQAEGV 253
Query: 1285 LKTTENIPGGAEEISEVLDSLENLMRHSE------DNPNQIRILAQTLTDGGVMDELINE 1338
T E P G I + + ++ + E D + LA L V + N
Sbjct: 254 RATWE--PIGDLFIDSLPEHIQAIKLFKEEFSPMKDGVKLVNDLAHQLAISDVHLSMENS 311
Query: 1339 E-LETFNSRWRELHEEAVRRQKLLEQS 1364
+ LE N RW++L R K L+ +
Sbjct: 312 QALEQINVRWKQLQASVSERLKQLQDA 338
Score = 32.7 bits (73), Expect = 6.8
Identities = 33/163 (20%), Positives = 73/163 (44%), Gaps = 21/163 (12%)
Query: 2053 SKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIF 2112
SK T+ Q + R ++A + WEK+ D+ +R++E+ ++
Sbjct: 185 SKDTSPKQRIQNLSRFVWKQATVASEL-WEKLTARCVDQHRHIERTLEQLLEIQGAMEEL 243
Query: 2113 NQWLTEAEQFLRKT----------QIPENWEHAK-YKWYLKELQDGIGQRQTVVRTLNAT 2161
+ L++AE +R T +PE+ + K +K ++DG+ + L +
Sbjct: 244 STTLSQAEG-VRATWEPIGDLFIDSLPEHIQAIKLFKEEFSPMKDGVKLVNDLAHQLAIS 302
Query: 2162 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEE 2204
+ ++S+ L +N+RW+++ +S+R K+L++
Sbjct: 303 DVHLSMENSQA--------LEQINVRWKQLQASVSERLKQLQD 337
>gi|5032305 dystrophin Dp40 isoform [Homo sapiens]
Length = 340
Score = 693 bits (1789), Expect = 0.0
Identities = 333/333 (100%), Positives = 333/333 (100%)
Query: 3072 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 3131
HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ
Sbjct: 8 HETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQ 67
Query: 3132 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 3191
HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR
Sbjct: 68 HNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIR 127
Query: 3192 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 3251
VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG
Sbjct: 128 VLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFG 187
Query: 3252 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 3311
GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI
Sbjct: 188 GSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNI 247
Query: 3312 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 3371
CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV
Sbjct: 248 CKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKV 307
Query: 3372 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET 3404
LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET
Sbjct: 308 LKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET 340
>gi|33188443 microfilament and actin filament cross-linker protein
isoform b [Homo sapiens]
Length = 5938
Score = 370 bits (950), Expect = e-101
Identities = 574/2872 (19%), Positives = 1190/2872 (41%), Gaps = 335/2872 (11%)
Query: 324 KSFGSSLMESEVNLDRYQTA-----LEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 378
++F L E+E ++ +T+ LE+ + L S D ++G + VE + + +
Sbjct: 2772 RTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL---VEEINCKGTSL 2828
Query: 379 EGYMMDLTA--HQGRVGNILQLGSKLIGT--GKLSEDEETEVQEQMNLLNSRWECLRVAS 434
E +M++TA QG+ G+IL +G+ G + + TE+Q M+ +N ++E L
Sbjct: 2829 ENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVL 2888
Query: 435 MEKQSNLHRVL--MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVL 492
E+Q +L +L M+ +++ + WL EE + M+ E +K Q + +K
Sbjct: 2889 HERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAF 2948
Query: 493 QEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQD 552
+LEQ ++ V + +G T ++ + W I RW +
Sbjct: 2949 LAELEQNSPKIQK------VKEALAGLLVTYPNSQE----AENWKKIQEELNSRWERATE 2998
Query: 553 ILLKWQRLTEEQ-----CLFSA------WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAV 601
+ + QR EE C +A WL EKE + + D N + + Q++
Sbjct: 2999 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI-DPNMLNAQKQQVQF 3057
Query: 602 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSV-TQKTEAWLDNFARCWDNLVQKLEKSTAQ 660
+ + E ++Q +L Q +L+ + S+ T + + L + + W L KL ++Q
Sbjct: 3058 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ 3117
Query: 661 ISQAVT-TTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIR-- 717
I QA+ +TQ + E V V R + Q + P K+Q+ SEIR
Sbjct: 3118 IDQAIVKSTQYQELLQDLSEKVRAVGQRLSV-----QSAISTQPEAVKQQLEETSEIRSD 3172
Query: 718 -KRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDA 776
++LD ++ E + + +VL ++ + + + +E A++ +LQ A
Sbjct: 3173 LEQLDHEVKEAQT-LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAA 3231
Query: 777 SRSAQALVEQMVNEGVNADSIKQAS-----------EQLNSRWIE---FCQLLSERLNWL 822
S Q +QM +E KQ+ E+L S+ E F + L++
Sbjct: 3232 LASTQQF-QQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSY 3290
Query: 823 EY---------------------QNNIIAFYNQLQQLEQMTTTAENWLK----------- 850
E QN ++ N ++L + T ++ LK
Sbjct: 3291 EVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW 3350
Query: 851 -IQPTTP--SEPTAIKSQLKICKDEVNRLSGL---QPQIERLKIQSIALKEKGQGPMFL- 903
++ P + A S+L++ D V S L + + ++ + L+ L
Sbjct: 3351 HVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILI 3410
Query: 904 ---DADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPM-----RYQETMSAIRTWVQQSE 955
+AD + + ++ A +ELQ +L M +QE+ I V+ ++
Sbjct: 3411 NSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAK 3470
Query: 956 TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP--SEISRK 1013
+L I ++ + L +L+A Q LQ + + YL + + + AP S+ S+
Sbjct: 3471 HQLEIFD-ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQL 3529
Query: 1014 -YQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 1072
+Q+E + E + ++ ++ C +E ++ + + ++ + +A++D L
Sbjct: 3530 LHQAEVAQQE--FLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGA 3587
Query: 1073 ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNT 1132
D++ L+ Q++ RL ++ I ++ + + + + E L+ EL+ LN
Sbjct: 3588 IGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNK 3647
Query: 1133 QWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE-EYLERDFEYKTPDELQK 1191
Q + ++ AR+E L+ L + + L +++ T AEE E L+ + Q+
Sbjct: 3648 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3707
Query: 1192 AVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ-EALKKELETLTTNYQWLCTRL 1250
+ KE+ + K++ + +I A + L+ ++E + + L ++
Sbjct: 3708 LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKV 3767
Query: 1251 NGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMR 1310
+ L+E + LE WL + E + + + + + + L R
Sbjct: 3768 AQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQR 3827
Query: 1311 HSEDNPNQIRILAQTLTDGGVMD--------ELINEELETFNSRWRELHEEAVRRQKLLE 1362
+D + +L +GG + E I +LE+ SRW EL +A RQK LE
Sbjct: 3828 LLDDRKATVDMLQ---AEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3884
Query: 1363 QSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEA---QKIQSDLTSHEIS 1419
+ A++ ++ I + L+ +K+LA A++ Q+ + ++ D+ +H
Sbjct: 3885 DILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATD 3944
Query: 1420 LEEMKKHNQG-----KEAAQRVLSQ-IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1473
+ + K Q A Q VLS+ ID Q + ++ + R +K A +Q L +++
Sbjct: 3945 VHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEI--QDRCCRKAALLDQALSNARLF 4002
Query: 1474 ----------LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1523
L EV+ L ++ K +Q+V+ Q + L + + K V+ IK G+
Sbjct: 4003 GEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQ 4062
Query: 1524 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1583
++++ E + E++ +K Y ++ ++ + LE+ +L+ K + LT WL
Sbjct: 4063 ALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWL 4122
Query: 1584 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQ----KVHLKSITEVGEALKTVLG 1639
+ EL A G S ++ + QKE++K+ ++ L ++ EV AL ++
Sbjct: 4123 REVEEEL----ATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVP 4178
Query: 1640 KKETLVEDKL-SLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL 1698
+ DKL S N + V+ + ++ + + + ++Q D W+ + L
Sbjct: 4179 WRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKL 4238
Query: 1699 D-----ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI 1753
E+ + + V K ++ + +D + + G+ + +++ +
Sbjct: 4239 MALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKT 4298
Query: 1754 SELNHRFAAIS-----HRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQ--GVNLKEE 1806
L ++ AIS + +A + + + + ++ +E A I Q + E
Sbjct: 4299 ESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHE 4358
Query: 1807 DFNKDMNE---------DNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNAL 1857
+ E +++ + +LL+ G L+ E EE ++ ++ Q N
Sbjct: 4359 QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLK-----ELNPEEGEMVEEKYQKAENMY 4413
Query: 1858 KDLRSQRRKKALEI------SHQWYQYKRQADDLLKCLDDIEKKLASLPE-PRDERKIKE 1910
++ + R++AL + S Q ++ + + +L+ L+++ +L P P + KI+E
Sbjct: 4414 AQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE 4473
Query: 1911 IDR-------ELQKKKEELNAVRRQAE-------GLSEDGAAMAVEPTQIQLSKRWREIE 1956
EL+K + A++R+ E G +D AA ++ Q+ W +I+
Sbjct: 4474 CISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIK 4533
Query: 1957 SKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNA 2016
++ A+ R + F + + E+ Y + LT I + ++E
Sbjct: 4534 AR-AEEREIKFLDVLELAEKFW------------YDMAALLTTIKDTQDIVHDLESPGID 4580
Query: 2017 PDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQ 2076
P + + +Q E+ + IK+ ++ I + + E+ ++++++ +
Sbjct: 4581 PSI-------IKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDE 4633
Query: 2077 LDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAK 2136
++ WE +NK +K+R + + +++ ++ ++ WL L T P +
Sbjct: 4634 MNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLC-TMPPVGTDLNT 4692
Query: 2137 YKWYLKELQD---GIGQRQTVVRTLNATGEEIIQQSS-KTDASILQEKLGSLNLRWQEVC 2192
K L E+++ + Q+Q + LN GE ++++++ +TD I++E L L W+ +
Sbjct: 4693 VKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLG 4752
Query: 2193 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNI--ASIPLEPGKEQQLKEKLEQVK 2250
++++ R+ +LE L +FQ L E + WL + + A P+ G + ++ +L +
Sbjct: 4753 EKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPIS-GDPKVIEVELAKHH 4811
Query: 2251 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ- 2309
+L ++ Q ++ +N+ G +L S+ + ++ L ++L+ N W V + E++
Sbjct: 4812 VLKNDVLAHQATVETVNKAGNELLESS--AGDDASSLRSRLEAMNQCWESVLQKTEEREQ 4869
Query: 2310 -------------GEIEAQIKDLGQLEKKL----------EDLEEQLNHLLLWLSPIRNQ 2346
EIE + +L ++E +L E EQL+ + S ++ +
Sbjct: 4870 QLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAK 4929
Query: 2347 LEIYNQPNQEGPFDV-QETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLED---L 2402
E YNQ +G + + +K +L + H+ K + K KLE+ L
Sbjct: 4930 EETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEER--KSKLEEALNL 4987
Query: 2403 SSEWK-------------------------AVNRLLQELRAKQP---------DLAPGLT 2428
++E++ +N +L ++ + D L
Sbjct: 4988 ATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELD 5047
Query: 2429 TIG-----ASPTQTVTLVTQPVVTKETAISK-----LEMPSSLMLEVPALADFNRAWTEL 2478
G S Q V L+ +V+ ++ K +E SL F+ AW +L
Sbjct: 5048 QTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKL 5107
Query: 2479 TDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTS 2538
DWL + + S+ + D + I + K K + L ++P + I + LK KT
Sbjct: 5108 IDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTL 5167
Query: 2539 NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAK 2598
E + + + ++++WD V R+ +L E L S Q+++A + L + +
Sbjct: 5168 LPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQ 5227
Query: 2599 LESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMI 2658
L + +D + + K K+L + V V +L+ + S DDT V
Sbjct: 5228 LAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-SRDDTTWVKGQ 5286
Query: 2659 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT---ANVLQDAT 2715
+ ++ W ++ K +++ LE+ + + F + L WL+EAE T L D T
Sbjct: 5287 LQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDT 5346
Query: 2716 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRL 2775
+ L D+ KE MK+ ++ + ++ + + +++ ++ D ++ +
Sbjct: 5347 EALQSLIDTH--KEFMKKVEEKRVDVNSAVAM--------GEVILAVCHPDCITTIKHWI 5396
Query: 2776 DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGD 2833
+ ++ E+ + + LE + + L+ELL W+Q + L + Q PI +
Sbjct: 5397 TIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQN 5456
Query: 2834 FPAVQKQNDVHRAFKRELKTKEPVI--------MSTLETVRIFLTEQPLEGLEKLYQEPR 2885
V+ H+ F E+ K+P + +E E+ G K +P
Sbjct: 5457 IDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQP- 5515
Query: 2886 ELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2937
PP + + + +++ W+++ L + + QRK+++ L+RL+EL+E
Sbjct: 5516 -TPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5566
Score = 351 bits (900), Expect = 9e-96
Identities = 526/2787 (18%), Positives = 1138/2787 (40%), Gaps = 333/2787 (11%)
Query: 380 GYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQS 439
G+ +DL HQ RV N+ + ++L T K E + + QEQ++ + E +
Sbjct: 2724 GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEG 2783
Query: 440 NLHRVLMDLQNQKLKE--------LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 491
++ + ++L++ L+DW +K T E G LE+L +
Sbjct: 2784 SIPPTETSMSAKELEKQIEHLKSLLDDWASKG---TLVEEINCKGTSLENL--------I 2832
Query: 492 LQEDLEQEQVRVNSLTHMV-VVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRW 547
++ Q + S+ V V +G H L E + D ++ + +R
Sbjct: 2833 MEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQ 2892
Query: 548 VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE 607
LQ IL + + + +E WL KE+ + + + E + + + KA L
Sbjct: 2893 ESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESN--KAFLA 2950
Query: 608 KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 667
+ +Q+ K+ +K+ L L +Q+ E W +I + + +
Sbjct: 2951 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENW-------------------KKIQEELNS 2991
Query: 668 TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 727
T+ TV ++RQ+ + ++L
Sbjct: 2992 RWERATEVTVA---------------------------RQRQLEESASHLACFQAAESQL 3024
Query: 728 HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 787
W+ E ++ + + K++V + +E + ++ + + +AQ ++
Sbjct: 3025 RPWLMEKE-LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGP 3083
Query: 788 VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQL-QQLEQMTTTAE 846
+ ++ +++ + +N +W+E L+ R + ++ Y +L Q L +
Sbjct: 3084 GDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVG 3143
Query: 847 NWLKIQPTTPSEPTAIKSQLK---------------------ICKDEVNRLSGLQPQIER 885
L +Q ++P A+K QL+ +C DE++ L G Q +
Sbjct: 3144 QRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLC-DELSVLIGEQYLKDE 3202
Query: 886 LK--IQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQET 943
LK ++++AL +G + D N + + Q ++Q+
Sbjct: 3203 LKKRLETVALPLQGLEDLAADR-----INRLQAALASTQ----------------QFQQM 3241
Query: 944 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE-- 1001
+RTW+ +++ + E ++ +L E + Q SL Q SG Y + E
Sbjct: 3242 FDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN-QHSGSYEVIVAEGESL 3300
Query: 1002 MSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMA 1061
+ P E R Q++ E++ W++LS + + +L++ M K +K Q H++ L W+
Sbjct: 3301 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 3360
Query: 1062 EVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFAS 1121
+ + E L D L+ L + + ++++++ + L +N + N +E +
Sbjct: 3361 DCKAKMSELRVTL-DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-ED 3418
Query: 1122 RLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDF 1181
+ E +N D + +++ A+ +L+ ++ Q+ + + + A+ + LE
Sbjct: 3419 GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ-LEIFD 3477
Query: 1182 EYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA-LKKELETLT 1240
+ K +E+++ +E Q E +V L ++ AP + + L + E
Sbjct: 3478 ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQ 3537
Query: 1241 TNYQWLCTRLNGKCKTLE---EVWACWH----ELLSYLEKANKWLNEVEFKLKTTENIPG 1293
+ + R+N C +E E +H E+ S L + L+ + + T+++
Sbjct: 3538 QEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQS 3597
Query: 1294 GAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDEL-INEELETFNSRWRELHE 1352
E++ L+ + L E + + R + L + G +D L + ELE N + +L E
Sbjct: 3598 QIEDVRLFLNKIHVLKLDIEASEAECRHM---LEEEGTLDLLGLKRELEALNKQCGKLTE 3654
Query: 1353 EAVRRQKLLEQSI-----------------QSAQETEKSLHLIQESLTFIDKQLA---AY 1392
RQ+ LE ++ +A+E E ++ + I++QLA +
Sbjct: 3655 RGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMF 3714
Query: 1393 IADKVDAAQMPQEAQK------IQS-----DLTSHEISLEEMKK--HNQGKEAAQRVLSQ 1439
++VD QM + IQS D+ E +EE+ + K+ AQR+
Sbjct: 3715 QKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA-- 3772
Query: 1440 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1499
+LQ+ + F+ L+ L + + + + S E +VV++Q+
Sbjct: 3773 ------QLQEALLHC------GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3820
Query: 1500 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1559
L + L + K+ V+M+ G +I Q + + +++ ++ +L+ + EL +K R+
Sbjct: 3821 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3880
Query: 1560 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1619
+QLE L L+++ + ++++L+ T+ +L V + + ++ KA +++IE
Sbjct: 3881 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3940
Query: 1620 QKVHLKSITEVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHME 1678
+ ++G++L ++ E ++ +K+ L + + + R LL + +
Sbjct: 3941 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR 4000
Query: 1679 TFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTR 1731
F ++ + W+ + + L K K+DVL R L E+ + + VD
Sbjct: 4001 LFGEDEVEVLNWLAEVEDKLSSVFVK--DFKQDVLHRQHADHLALNEEIVNRKKNVDQAI 4058
Query: 1732 DQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1791
L+ L++ ++ + R+A I+ + + KA L++ Q + Q E
Sbjct: 4059 KNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT--VTSSKALRTLEQARQLATKFQSTYE 4116
Query: 1792 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1851
L +++ ++EE + + QR L++ + + R + +
Sbjct: 4117 ELTGWLRE---VEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR------LVLDTVN 4167
Query: 1852 TKHNALKDLRSQRRKKALE--ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIK 1909
AL +L R ++ L+ +S QYK +D + + +D+I+ + R ++ +
Sbjct: 4168 EVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQ-----RSQQYEQ 4222
Query: 1910 EIDREL------QKKKEELNAVRRQAEGLSEDGAAMAVEPT-QIQLSKRWREIESKFAQ- 1961
D EL ++K L +R + + + A + V+ I + + ++ F+
Sbjct: 4223 AADAELAWVAETKRKLMALGPIRLEQD---QTTAQLQVQKAFSIDIIRHKDSMDELFSHR 4279
Query: 1962 ---FRRLNFAQIHTVREETMMVMTEDMPLEI------------SYVPSTYLTEITHVSQA 2006
F Q ++E+T ++ + + + + + + +S
Sbjct: 4280 SEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 4339
Query: 2007 LLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVE 2066
+ E L+ A D E L +Q+E ++ +++S+ + ID + K L+ P E
Sbjct: 4340 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKL-LKIGPQLKELNPEE 4398
Query: 2067 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRR---FHYDIKIFNQWLTEAEQFL 2123
++E + + + ++ + + R D +V + + FH I+ + L L
Sbjct: 4399 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRL 4458
Query: 2124 RKTQ-IPENWEHAKYKWYLKELQDG---IGQRQTVVRTLNATGEEIIQQSSKTDASI--- 2176
R IP E K + + + + + + Q L GEE+I +S D +
Sbjct: 4459 RMPPLIPA--EVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAK 4516
Query: 2177 -LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLE 2235
+Q+KL + W+++ + +R+ + + + +F D+ + +++ +I
Sbjct: 4517 EIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLES 4576
Query: 2236 PGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2294
PG + + K+++E + + EE L+ + G ++ + E+ ++ + +
Sbjct: 4577 PGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC--GETEKPEVRKSIDEM 4634
Query: 2295 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYN 2351
N W +++ E+ ++E ++ Q + L+ + + L++ ++ L P+ L
Sbjct: 4635 NNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVK 4694
Query: 2352 QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNR 2411
E ++E ++ V +Q ++E++ +G+ + K+ AT R + +
Sbjct: 4695 DQLNE----MKEFKVEVYQQQIEMEKLNHQGELMLKK--ATDETDRDI---------IRE 4739
Query: 2412 LLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADF 2471
L EL+ +L ++ A + ++ +L+ AL F
Sbjct: 4740 PLTELKHLWENLG-----------------------EKIAHRQHKLEGALL----ALGQF 4772
Query: 2472 NRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 2531
A EL WL+ ++++ +QR + GD + I + K D+ + +E + A
Sbjct: 4773 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4832
Query: 2532 NLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQV 2591
L ++ +A + + R+E + W+ V + + R QQL L+ + + E+
Sbjct: 4833 ELLESSAGDDASS-LRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4891
Query: 2592 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR-QWQTNVDVANDLALKLLRDYSAD 2650
L + ++L + K + ++++ +L L+ + +T + + L LL +
Sbjct: 4892 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4951
Query: 2651 DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV 2710
K + W + ++ ER++ LEE L +F L++F+ WLT AE + N+
Sbjct: 4952 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 5011
Query: 2711 LQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVL 2770
A+ +L V +++ + E+ AH D LD+ + L+ L D VL
Sbjct: 5012 ---ASPPSLILNT---VLSQIEEHKVFANEVNAHRDQIIELDQTGNQ-LKFLSQKQDVVL 5064
Query: 2771 LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPI 2830
++ L ++ +W ++ ++S+ L+ + + K+ H + ++L+ WL+ + L + I
Sbjct: 5065 IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEI 5124
Query: 2831 GGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE 2890
D ++ Q H+ F++ L K+PV +T+ T R + + L PE
Sbjct: 5125 SNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL--------------KEKTLLPE 5170
Query: 2891 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 2950
+ +Q + L EV +W+ + S + Q K++E L + +A L L + E
Sbjct: 5171 D-SQKLDNFL----GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVE 5225
Query: 2951 VIKGSWQPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYN 3009
QPV GDL D + + ++ K + E+ V + R+L + +
Sbjct: 5226 PQLAEDQPVHGDL--DLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV 5283
Query: 3010 LSTLEDLNTRWKL---LQVAVEDRVRQ 3033
L++L+TRW L V+ + R+ Q
Sbjct: 5284 KGQLQELSTRWDTVCKLSVSKQSRLEQ 5310
Score = 296 bits (757), Expect = 3e-79
Identities = 510/2885 (17%), Positives = 1162/2885 (40%), Gaps = 305/2885 (10%)
Query: 339 RYQTALEEVLSWLLSAEDTLQA--QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 396
++Q + + + +W+ + E ++ +++D V+++Q T + +L HQ V +
Sbjct: 2438 QFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQ 2497
Query: 397 QLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN--QKLK 454
++ ++ + VQE + + S ++ L + E+ S L + + Q+ + L+
Sbjct: 2498 KVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLE 2557
Query: 455 ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVD 514
L + + E+ + L + ++ + + L++D+ +++ + + MV
Sbjct: 2558 SLLQSIGEVEQNLEGKQVSSLSSGV--IQEALATNMKLKQDIARQKSSLEATREMVTRFM 2615
Query: 515 ESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEK 574
E++ A L+ +L + R+ +C +++ L+ +L + + S L +
Sbjct: 2616 ETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH----LSGKLQQF 2671
Query: 575 EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQ 634
+ +++ +G + ++ Q++ L ++E +++++ L L +L S + Q
Sbjct: 2672 MENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQ 2731
Query: 635 KTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQP--SLTQTTVMETVTTVTTREQILV 692
+ VQ L K ++ + V + S Q + E V T ++ L
Sbjct: 2732 HQDR------------VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWL- 2778
Query: 693 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 752
K + +PP + E+ K+++ + L W ++ V + I K +
Sbjct: 2779 KETEGSIPPTETSMSAK-----ELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSL 2828
Query: 753 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE------QLNS 806
+L ++ A + Q + S V V + K +E +N
Sbjct: 2829 ENLIMEITAPDS---------QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNL 2879
Query: 807 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQP---------TTPS 857
++ + +L ER Q ++ A N+++++ + + WL+ + ++P+
Sbjct: 2880 KYEKLGGVLHER------QESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2933
Query: 858 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIAL------KEKGQGPMFLDADFVAFT 911
+ +K+Q + K + L P+I+++K L ++ + + +
Sbjct: 2934 KTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEEL---N 2990
Query: 912 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 971
+ +++ AR+++L+ L +Q S +R W+ + E + + D ++
Sbjct: 2991 SRWERATEVTVARQRQLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSIDPNML 3048
Query: 972 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS---RKYQSEFEEIEGRWKKL 1028
+ ++Q + + ++ L+ + + P ++S + Q E + I +W +L
Sbjct: 3049 NAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQKWVEL 3107
Query: 1029 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1088
+ +L ++++ + K + Q +Q L + + V L + E +K+QL++
Sbjct: 3108 TDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETS 3167
Query: 1089 LLVSDIQTIQPSLN---------SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1139
+ SD++ + + SV G Q +K+E + RLET L D
Sbjct: 3168 EIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELK----KRLETVALPLQGLEDLAAD 3223
Query: 1140 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1199
++ L+ L T Q+ E+ W+ + + + + LQ ++E +
Sbjct: 3224 RI----NRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEF 3279
Query: 1200 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQE-ALKKELETLTTNYQWLCTRLNGKCKTLE 1258
++ Q +++ S++ PP ++ L+ +L L +++ L + + L+
Sbjct: 3280 QKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLK 3339
Query: 1259 EVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQ 1318
+ + ++E W+ + + K+ + S +L S + ++ E +
Sbjct: 3340 DCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRS-KAMLNEVEKRRSL 3398
Query: 1319 IRIL---AQTLTDGGVMDEL-INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1374
+ IL A L + DE I +E N + EE + LE+ Q +E ++S
Sbjct: 3399 LEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 3458
Query: 1375 LHLIQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-- 1430
I++ + QL + + + + + ++ + Q L + E ++ ++ QG
Sbjct: 3459 FKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVE 3518
Query: 1431 -----EAAQRVLSQIDVAQKKLQDVSMKFRL--------FQKPANFEQRLQESKMILDEV 1477
A ++L Q +VAQ++ +V + + F R++E L ++
Sbjct: 3519 DAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADL 3578
Query: 1478 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1537
L + + + +QSQ+ + +K ++E R +++++ T + L
Sbjct: 3579 DDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGL 3638
Query: 1538 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1597
+ AL +L + R++QLE L +++ L + A + + V
Sbjct: 3639 KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVG 3698
Query: 1598 GMPSNLDSEVAWGKATQKE-IEKQKVHLKSITEVGEALKTVLGKKETL--VEDKLSLLNS 1654
++ ++A K QKE ++ ++ L+ + +G+ L GK + +E + +N+
Sbjct: 3699 TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINA 3758
Query: 1655 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLK 1714
W + + + + L E H F ++ + W+ + L+ + +K P + V+K
Sbjct: 3759 RWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI--ANQKPPSAEYKVVK 3816
Query: 1715 R-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI 1767
L+ L+D + VD + + + + R+ + Q+ L R+ +
Sbjct: 3817 AQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL---- 3872
Query: 1768 KTGKASIPLKELEQ-----------------FNSDIQKLL---EPL---EAEIQQGVNLK 1804
KA+ K+LE F S +K L EP+ A+IQQ + ++
Sbjct: 3873 -LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI-IR 3930
Query: 1805 EEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQR 1864
+ +D+ E++ V + ++ G +L +T ++ + K LQ +++ ++D ++
Sbjct: 3931 HKALEEDI-ENHATDVHQAVKIGQSLSS-LTSPAEQGVLSEKIDSLQARYSEIQDRCCRK 3988
Query: 1865 RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK----- 1919
+ + ++L L ++E KL+S+ +K+ +++ ++
Sbjct: 3989 AALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-------FVKDFKQDVLHRQHADHL 4041
Query: 1920 ---EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1976
EE+ ++ + ++G A+ + T ++ +++ + +A I +
Sbjct: 4042 ALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI-----KTRYADITVTSSK 4096
Query: 1977 TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKN 2036
+ + + L + STY ++ L EVE+ L + E + + ++ K
Sbjct: 4097 ALRTLEQARQLATKF-QSTY----EELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKE 4151
Query: 2037 IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 2096
+K + + +D ++ A L+ R L + +S + Q++ V+ R D
Sbjct: 4152 LKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEID 4211
Query: 2097 RSVEKWRRFHYDIKIFNQWLTEAEQFLRKT---QIPENWEHAKYKWYLKELQDGIGQRQT 2153
++++ +++ W+ E ++ L ++ ++ A+ + K I + +
Sbjct: 4212 AAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ-VQKAFSIDIIRHKD 4270
Query: 2154 VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 2213
+ L + EI + ++LQEK SL +++ + S+R RLE + ++++F
Sbjct: 4271 SMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW 4330
Query: 2214 RDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGP 2272
E W+EE IA +P +QL+++ E+++ L E + + + +L + G
Sbjct: 4331 ETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ 4390
Query: 2273 VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ---GEIEAQIKDLGQLEKKLEDL 2329
+ ++PEE + +E K ++ + ++ + ++ E +Q + + K+E +
Sbjct: 4391 L---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 4447
Query: 2330 EEQLNHLL--LWLSPIR----NQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2383
E L +L L + P+ +++ N+ ++++ + + +A + EE++ + Q
Sbjct: 4448 LETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4507
Query: 2384 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK-----------QPDLAPGLTTIG- 2431
K+ A + ++ KL+ + W+ + +E K D+A LTTI
Sbjct: 4508 GADKDLAAKE-IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4566
Query: 2432 --------ASPTQTVTLVTQPVVTKETA---------------------------ISKLE 2456
SP +++ Q V ET K E
Sbjct: 4567 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4626
Query: 2457 MPSSLMLEVPALADFNRAWTE---------------------LTDWLSLLDQVIKSQRVM 2495
+ S+ A + N+ W E + DWL + + +
Sbjct: 4627 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPV 4686
Query: 2496 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2555
DL + + + + K ++ Q++ ++E+L + + K +++ R II + + +++
Sbjct: 4687 GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKH 4746
Query: 2556 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2615
W+ + E + +R+ +L L Q+ A EE L L++ + I+ +
Sbjct: 4747 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4806
Query: 2616 ITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSE 2675
+ + L D+ Q V+ N +LL + DD + E +N W S+ ++ E
Sbjct: 4807 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4866
Query: 2676 REAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQ 2735
RE L+ T + Q F ++E FL LT E+ + A++ L ++ +E +
Sbjct: 4867 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS----ASKPTGGLPET--AREQLDTHM 4920
Query: 2736 DLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSH 2795
+L +++A + Y+ L + + +L S + S ++ + + KW + K +S
Sbjct: 4921 ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSK 4980
Query: 2796 LEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 2855
LE + + SLQE + WL L + L+ +P V Q + H+ F E+
Sbjct: 4981 LEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHR 5040
Query: 2856 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 2915
I+ +L Q +L + Q+V L++ V + WEK+
Sbjct: 5041 DQII-------------------ELDQTGNQLKFLSQKQDVV-LIKNLLVSVQSRWEKVV 5080
Query: 2916 LHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG---DLLIDSLQDHLE 2972
S + R +D+ +R ++ EA +L L AE S + D + L H E
Sbjct: 5081 QRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKE 5140
Query: 2973 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVR 3032
K L G+ P+ + ++ T L + + L ++ +W + +R
Sbjct: 5141 FQKTLGGK-QPVYDTTIRTGRALKEKTLLPEDSQKLD-NFLGEVRDKWDTVCGKSVERQH 5198
Query: 3033 QLHEA 3037
+L EA
Sbjct: 5199 KLEEA 5203
Score = 259 bits (663), Expect = 3e-68
Identities = 534/2921 (18%), Positives = 1135/2921 (38%), Gaps = 320/2921 (10%)
Query: 324 KSFGSSLMESEVNLDRYQTALEEVL----------SWLLSAEDTLQAQGEISNDVEVVKD 373
+ + +SL +SE L + QT +E+ SWL +E L+ + + E +
Sbjct: 2296 EQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPS 2355
Query: 374 QFHTHEGYMMDLTAHQGRVGNILQLGSKLIGT------GKLSEDEETEVQEQMNLLNSRW 427
+ D+ +H+G + + G K++ GK + V++++ R+
Sbjct: 2356 LLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERY 2415
Query: 428 ECLRVASMEKQSNLHRVLMDLQN--QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQ 485
L S+L+ +L L W+ E K+ + + D L+ Q
Sbjct: 2416 TALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQ 2475
Query: 486 VQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTED 545
+ K LQE+L + QV V L + + E G+ A Q
Sbjct: 2476 LATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQ----------------- 2518
Query: 546 RWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKAD 605
IL +Q L S L+E+ + K Q + S LQ + ++ +
Sbjct: 2519 --ETTDSILSHFQSL-------SYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQN 2569
Query: 606 LEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAV 665
LE K+ S +++ L + +K K + ++ L+ ++ + +TA + Q
Sbjct: 2570 LEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGK 2629
Query: 666 TTTQPSLTQTTVMETVTTVTTREQIL-----VKHAQEELPPPPPQKKRQITVDSEIRKRL 720
+ ++ ++ +++L +H +L K R + ++
Sbjct: 2630 LAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQ----P 2685
Query: 721 DVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSA 780
D DIT I ++ + + E ++L A+ + + ++Q+ +
Sbjct: 2686 DQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL--DLCQHQDRVQNLRKDF 2743
Query: 781 QALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ 840
L + + +A S ++ ++ F + L E + ++ +Q+E
Sbjct: 2744 TELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEH 2803
Query: 841 MTTTAENWLKIQPTTPSEPTAIKSQLK------ICKDEVNRLSGLQPQIERLKIQSIALK 894
+ + ++W + T E + L+ D + + P + + S+
Sbjct: 2804 LKSLLDDWAS-KGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGS-SVGSVNGY 2861
Query: 895 EKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQS 954
+ + D ++++ + R++ LQ I + + + ++E S ++ W++
Sbjct: 2862 HTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEV-HKEANSVLQ-WLESK 2919
Query: 955 ETKLSI--PQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEIS 1011
E L S T E ++ + +A + L++ + + + + P S+ +
Sbjct: 2920 EEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEA 2979
Query: 1012 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1071
++ EE+ RW++ + V ++LEE + L Q L+ W+ E ++ +
Sbjct: 2980 ENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLG 3039
Query: 1072 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPE--FASRLETELKE 1129
P D +L Q +Q + ++ + + + +NE Q I S+++ EL+
Sbjct: 3040 PLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQS 3099
Query: 1130 LNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDEL 1189
+N +W + ++ +R + + K+ Q+ L ++ E + + + P+ +
Sbjct: 3100 INQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAV 3159
Query: 1190 QKAVEEMKRAKEEAQQKEAKVK---LLTESVNSVIAQAPPVAQEALKKELETLTTNYQWL 1246
++ +EE + + +Q + +VK L + ++ +I + ++ LKK LET+ Q L
Sbjct: 3160 KQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGE--QYLKDELKKRLETVALPLQGL 3217
Query: 1247 CTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLE 1306
+ L+ A + ++ WL++ + + I E + L E
Sbjct: 3218 EDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENE 3277
Query: 1307 NLMRHSEDNPNQIRILAQ------TLTDGGVMDELINEELETFNSRWRELHEEAVRRQKL 1360
+ + ++ G + +L + W EL ++ RQ
Sbjct: 3278 EFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSR 3337
Query: 1361 LEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISL 1420
L+ +Q AQ+ + +++ + +I+ A K+ ++ + +++S L + L
Sbjct: 3338 LKDCMQKAQKYQWH---VEDLVPWIEDCKA-----KMSELRVTLDPVQLESSLLRSKAML 3389
Query: 1421 EEMKKHNQGKE----AAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDE 1476
E++K E AA +++ + + ++D K + Q + LQ L+E
Sbjct: 3390 NEVEKRRSLLEILNSAADILINSSEADEDGIRD--EKAGINQNMDAVTEELQAKTGSLEE 3447
Query: 1477 VKMHLPALET--KSVEQEV--------------VQSQLNHCVNLYKSLSEVKSEVEMVIK 1520
+ L + K++E++V Q+ N + ++ EV +E +
Sbjct: 3448 MTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVD 3507
Query: 1521 TGRQIVQKKQTENPKELDERVTALKLHYNELG-AKVTERKQQLEK-CLKLSRKMRK---- 1574
R Q + P D + LH E+ + E KQ++ C+ + K+
Sbjct: 3508 YLRNFTQGLVEDAPDGSD---ASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQF 3564
Query: 1575 --EMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVH-LKSITEVG 1631
+ + LA D EL A+ +L S++ + K+H LK E
Sbjct: 3565 HCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQI-----EDVRLFLNKIHVLKLDIEAS 3619
Query: 1632 EA-LKTVLGKKETL----VEDKLSLLNSNWIAVTSRA---EEWLNLLLEYQKHMETFDQN 1683
EA + +L ++ TL ++ +L LN +T R +E L L L +E F +
Sbjct: 3620 EAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTL---GRVEDFYRK 3676
Query: 1684 VDHITKWIIQADTLLDESEKKK----------PQQKEDVLKRLKAELNDIRPKVDSTRDQ 1733
+ K + A T +E+E + QQ D K +++ ++ K+
Sbjct: 3677 L----KGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGL 3732
Query: 1734 AANLMANRGDHCR-KLVEPQISELNHRFAAISHRI------------KTGKASIPLKELE 1780
L+ + G C + +E + E+N R+ ++ ++ GK L+ L
Sbjct: 3733 GQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLL 3792
Query: 1781 QFNSDIQKLL---EPLEAEIQ-QGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITD 1836
+ +D ++L+ +P AE + ++E+ + + +D + TV L G + Q +
Sbjct: 3793 SWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQS-AE 3851
Query: 1837 ERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL 1896
RE+I + + L+++ L + R+K+ +I Q+ A+ + L EKKL
Sbjct: 3852 LADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKL 3911
Query: 1897 A-SLPEPRDERKIKE---IDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRW 1952
A S P KI++ + L++ E QA + + +++ Q LS++
Sbjct: 3912 ANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKI 3971
Query: 1953 REIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQ 2012
+++++++ Q R+ ++ D L + + + + V L EVE
Sbjct: 3972 DSLQARYSEI------QDRCCRKAALL----DQALSNARL---FGEDEVEVLNWLAEVED 4018
Query: 2013 LLNAPDLCAKDFED--LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 2070
L++ + KDF+ L +Q + + + +D A L+ T E + +
Sbjct: 4019 KLSS--VFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLI 4076
Query: 2071 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT--QI 2128
QE L + ++ + +++ + +F + WL E E+ L + Q
Sbjct: 4077 QEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQS 4136
Query: 2129 PENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRW 2188
P + +++ KEL+ + + + V+ T+N +++ L + + N ++
Sbjct: 4137 PTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQY 4196
Query: 2189 QEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKL 2246
+ V + R ++ ++++ + + W+ E +A P+ ++Q +
Sbjct: 4197 KLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ 4256
Query: 2247 EQVKLLV----------EELPLRQGILKQLNETGGPVL---VSAPISPEEQDKLENKLKQ 2293
Q + E R I E VL + I E L N +
Sbjct: 4257 VQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERY 4316
Query: 2294 TNLQ------------------WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQL-- 2333
L+ WI+ +RAL + + L Q ++++ L E +
Sbjct: 4317 ARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAE 4376
Query: 2334 --NHL--LLWLSPIRNQL-----EIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQH 2384
H+ LL + P +L E+ + Q+ + + V+ + ++E +S+
Sbjct: 4377 HKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQ 4436
Query: 2385 LYKEKPATQPVKRKLEDLSSEWK-------AVNRLLQ----------ELRAKQPDLAP-- 2425
+ + +P+ LE+LSS + V+++ + EL QP
Sbjct: 4437 ITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALK 4496
Query: 2426 --GLTTIGASPTQTVTLVTQPVVTK--------ETAISKLEMPSSLMLEVPALADFNRAW 2475
G IG S L + + K E ++ E L+V LA+ + W
Sbjct: 4497 RRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAE--KFW 4554
Query: 2476 TELTDWLSLLDQVIKSQRVMVGDLED--INEMIIKQKA-TMQDLEQRRPQLEELITAAQN 2532
++ L+ IK + +V DLE I+ IIKQ+ + +++ L E + +
Sbjct: 4555 YDMAALLT----TIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRI 4610
Query: 2533 LKNK---TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAE 2589
L + + + I+ + N W+ + + + R ++L + ++ + Q+ + +
Sbjct: 4611 LGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMF 4670
Query: 2590 QVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA 2649
L KL + ++ ++ ++ E K+ ++ Q Q ++ N +L+ +
Sbjct: 4671 DWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATD 4730
Query: 2650 DDTRKV--HMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 2707
+ R + +TE + W ++ ++++ R+ LE L QF LE+ ++WLT E
Sbjct: 4731 ETDRDIIREPLTE-LKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEE- 4788
Query: 2708 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 2767
L DA R + D K ++ + + L+ ++ AH +++ ++L S G DD
Sbjct: 4789 ---LLDAQRP--ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAG-DD 4842
Query: 2768 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2827
A L+ RL+ MN W + +K+ L+++ Q + H +++ L+ L + +LS
Sbjct: 4843 ASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSAS 4902
Query: 2828 APIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL 2887
P GG ++Q D H +LK KE L+ R+ L + G
Sbjct: 4903 KPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG----------- 4951
Query: 2888 PPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLR 2947
+ Q+V L +K W ++ + + K++E L E Q + E L
Sbjct: 4952 SGSKTEQSVALLEQK--------WHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLT 5003
Query: 2948 QAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSP 3007
AE P L+++++ +E+ K E+ ++ + ++ QL L +
Sbjct: 5004 LAEQSLNIASP-PSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDV 5062
Query: 3008 YNL-STLEDLNTRW-KLLQVAVE---------DRVRQLHEA 3037
+ + L + +RW K++Q ++E R +Q HEA
Sbjct: 5063 VLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEA 5103
Score = 233 bits (594), Expect = 3e-60
Identities = 536/2936 (18%), Positives = 1125/2936 (38%), Gaps = 426/2936 (14%)
Query: 333 SEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKD--QFHTHEGYMMDLTAHQG 390
SE+++D L++ ED Q E ++ + QF E + DL+ Q
Sbjct: 1952 SEIDVDSLNLCLQQY-------EDLKQPMAERKAQLDALAFDIQFFISE-HAQDLSPQQN 2003
Query: 391 RVGNILQLGSKLIGTGK-LSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ 449
R +L+L ++L + + + E +V L + V +++KQ N
Sbjct: 2004 R--QMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTC------- 2054
Query: 450 NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 509
+Q+L++L W+ + E + DL L++ K LQ+D++ N T
Sbjct: 2055 HQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQ------NRATSF 2108
Query: 510 VVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSA 569
VV + G +EE L R R L +++ L EE +
Sbjct: 2109 ATVVKDIEG-----FMEENQTKLSPRELTALR------EKLHQAKEQYEALQEETRVAQK 2157
Query: 570 WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL---KQDLLST 626
L E + + T K E+ + +K+ L + S G+L + + L
Sbjct: 2158 ELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA 2217
Query: 627 LKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVT---- 682
K T+ ++ + + L ++ E A+ + ++ Q + T +
Sbjct: 2218 SLEKGALDTTDGYM-GVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHG 2276
Query: 683 -TVTTREQILVKHAQEE--------LPPPPPQKKRQITVDSEIRKRLDVDITELHSWITR 733
+T EQ +++ E L + K+ T+ E++K L D E SW+ R
Sbjct: 2277 HNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQ-DHKEFESWLER 2335
Query: 734 SEAVLQ-------SPEF--AIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV 784
SE L+ SPE ++ +++G+FS+ R +K+ D S +
Sbjct: 2336 SEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGK 2395
Query: 785 EQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTT 844
E + D +K A+E+ + + C L LN L Q + F N L+
Sbjct: 2396 EPSEIGNLVKDKLKDATERYTALHSK-CTRLGSHLNMLLGQYH--QFQNSADSLQAWMQA 2452
Query: 845 AENWLK--IQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERL-KIQSIALKEKGQ--- 898
E ++ + T S+P ++ QL K L+ Q +E+L K+ ++ +G+
Sbjct: 2453 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2512
Query: 899 GPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKL 958
+ + +HF+ + + R LQ QE++ ++ + + E L
Sbjct: 2513 DHRHVQETTDSILSHFQSLSYSLAERSSLLQKAI--AQSQSVQESLESLLQSIGEVEQNL 2570
Query: 959 SIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEF 1018
Q+S ++++ L L+ + Q+S L V + A S + Q +
Sbjct: 2571 EGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKL 2630
Query: 1019 EEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGD-- 1076
E+ R+++L C + +E+ + L+K+ + + ++ F++ + L
Sbjct: 2631 AEVSQRFEQL-------CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN 2683
Query: 1077 --SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQW 1134
+ + +Q + L +++ Q +L+++ ++ + + + ++ L +
Sbjct: 2684 QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDF 2743
Query: 1135 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1194
+ + V R++ E+ +K + +W+ + E + + EL+K +E
Sbjct: 2744 TELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS-MSAKELEKQIE 2802
Query: 1195 EMKRAKEEAQQKEAKVKLL----TESVNSVIAQAPPVAQ--------------------- 1229
+K ++ K V+ + T N ++ P +Q
Sbjct: 2803 HLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH 2862
Query: 1230 -----EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1284
++ ++ + Y+ L L+ + ++L+ + E+ +WL E
Sbjct: 2863 TCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEV 2922
Query: 1285 LKTTE--NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEE--- 1339
LK+ + + P E + +S + + E N +I+ + + L G++ N +
Sbjct: 2923 LKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL--AGLLVTYPNSQEAE 2980
Query: 1340 -----LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIA 1394
E NSRW E V RQ+ LE+S + + ++ L + +
Sbjct: 2981 NWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGP 3040
Query: 1395 DKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLS-------QIDVAQKKL 1447
+D + + Q++Q L E ++H Q EAAQ +L+ QK+L
Sbjct: 3041 LSIDPNMLNAQKQQVQFMLKEFE---ARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKEL 3097
Query: 1448 QDVSMKF---------------RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQE 1492
Q ++ K+ + K +++ LQ+ + V L S + E
Sbjct: 3098 QSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPE 3157
Query: 1493 VVQSQLNHCVNLYKSLSEVKSEV--------EMVIKTGRQIVQKKQTENPKELDERVTAL 1544
V+ QL + L ++ EV E+ + G Q ++ EL +R+ +
Sbjct: 3158 AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK-------DELKKRLETV 3210
Query: 1545 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1604
L L +R +L+ L +++ ++ + L WL + K + L
Sbjct: 3211 ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQ 3270
Query: 1605 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL--GKKETLVEDKLSLLNSNWIAVTSR 1662
S++ + QK + + + I GE+L + G+++ ++++L L ++W ++ +
Sbjct: 3271 SQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKK 3330
Query: 1663 AEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE-KKKPQQKEDVLKRLKAELN 1721
+ + L + + + + +V+ + WI + E P Q E L R KA LN
Sbjct: 3331 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN 3390
Query: 1722 DI--RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIP---- 1775
++ R + + AA+++ N + + + + +N A++ ++ S+
Sbjct: 3391 EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQ 3450
Query: 1776 -LKELEQFNSDIQKLLEPLEAEIQ----------QGVNLKE------------------E 1806
L+E ++ +I+K +E + +++ NL++
Sbjct: 3451 RLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLR 3510
Query: 1807 DFNKDMNED--NEGTVKELLQRGDNLQQRITDERKREE-----IKIKQQLLQTKHNALKD 1859
+F + + ED + +LL + + QQ + ++R ++ K + + H +++
Sbjct: 3511 NFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVRE 3570
Query: 1860 LRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEID------- 1912
+ SQ E+ R D L ++D+ L + + + + E +
Sbjct: 3571 MFSQLADLDDELDGMG-AIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEE 3629
Query: 1913 ---RELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQ 1969
+L K EL A+ +Q L+E G A Q QL +E + + + LN A
Sbjct: 3630 EGTLDLLGLKRELEALNKQCGKLTERGKA-----RQEQLELTLGRVEDFYRKLKGLNDAT 3684
Query: 1970 IHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFK 2029
E + + TE+ ++Q L + +
Sbjct: 3685 TAAEEAEALQWVVG--------------TEVEIINQQLADFKMF---------------- 3714
Query: 2030 QEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVK-LQEALSQLDFQWEKVNKMY 2088
Q+E + ++ LQQ +G +QSA V+ L+ + +++ +W +NK
Sbjct: 3715 QKEQVDPLQMKLQQVNG-------LGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKV 3767
Query: 2089 KDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKE---LQ 2145
R + ++ +F ++ WL + E+ + Q P + E+ K ++E LQ
Sbjct: 3768 AQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI-ANQKPPSAEYKVVKAQIQEQKLLQ 3826
Query: 2146 DGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQ 2205
+ R+ V L A G I Q + D + +L SL RW E+ + + R+K+LE+
Sbjct: 3827 RLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDI 3886
Query: 2206 KNILSEFQ---RDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGI 2262
+ +F +++F+ E+ +A+ + ++++++ + K L E++
Sbjct: 3887 LVLAKQFHETAEPISDFLSVTEK--KLANSEPVGTQTAKIQQQIIRHKALEEDIENHATD 3944
Query: 2263 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 2322
+ Q + G +S+ SP EQ L K+ ++ ++ K ++ + +
Sbjct: 3945 VHQAVKIGQS--LSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLF 4002
Query: 2323 EKKLEDLEEQLNHLLLWLSPIRNQL-EIYNQPNQEGPFDVQETE-----IAVQAKQPDVE 2376
ED E LN WL+ + ++L ++ + ++ Q + + ++ +V+
Sbjct: 4003 G---EDEVEVLN----WLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVD 4055
Query: 2377 EILSKGQHLYKEKPATQP--VKRKLEDLSSEW--------KAVNRLLQE----------- 2415
+ + GQ L K+ + ++ KL+ + + + KA+ L Q
Sbjct: 4056 QAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTY 4115
Query: 2416 ------LRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA 2469
LR + +LA T+ G SPT Q ++ + K M L+L+ +
Sbjct: 4116 EELTGWLREVEEELA---TSGGQSPTGEQIPQFQ---QRQKELKKEVMEHRLVLD--TVN 4167
Query: 2470 DFNRAWTELTDWLSL--LDQVI---KSQRVMVGD-----LEDINEMIIK----------- 2508
+ +RA EL W + LD+++ Q +V D +++I+ I +
Sbjct: 4168 EVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAE 4227
Query: 2509 ------------------------------QKATMQDLEQRRPQLEELITAAQNLKNKTS 2538
QKA D+ + + ++EL + + T
Sbjct: 4228 LAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFG-TC 4286
Query: 2539 NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAK 2598
+E +T++ ++ E + Q++ + R +L Q+ E EE + + RA
Sbjct: 4287 GEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRAL 4346
Query: 2599 LESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLA--LKLLRDYSADDTRKVH 2656
+ + ++++ E +QL + + + + ++D + LK L + + +
Sbjct: 4347 IAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKY 4406
Query: 2657 MITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATR 2716
EN+ A I + V +R AL+E Q +K L ET N+
Sbjct: 4407 QKAENMYA---QIKEEVRQRALALDEAVSQSTQITEFHDKIEPML---ETLENLSSRLRM 4460
Query: 2717 KERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD---AVLLQR 2773
+ + ++E + + E+E + L ++++ +G+D A +Q
Sbjct: 4461 PPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQD 4520
Query: 2774 RLDNMNFKWSELR----KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP 2829
+LD M F W +++ ++ + LE + W + LL ++ D +
Sbjct: 4521 KLDQMVFFWEDIKARAEEREIKFLDVLELAEKFW----YDMAALLTTIKDTQDIVHDLES 4576
Query: 2830 IGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPP 2889
G D +++Q + K E + LE +RI G + ++ P
Sbjct: 4577 PGIDPSIIKQQVEAAETIKEETDG----LHEELEFIRIL-------GADLIFACGETEKP 4625
Query: 2890 EERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQA 2949
E +RK +E+N WE LN W+ ++++ + +Q + D L
Sbjct: 4626 E---------VRKSIDEMNNAWENLN---KTWKERLEKLEDAMQAAVQYQDTLQAMFDWL 4673
Query: 2950 E--VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLK---ENVSHVNDLARQLTT 3000
+ VIK P +++++D L ++K + E+ + E ++H +L + T
Sbjct: 4674 DNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKAT 4729
Score = 204 bits (518), Expect = 2e-51
Identities = 416/2145 (19%), Positives = 855/2145 (39%), Gaps = 311/2145 (14%)
Query: 1033 VEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVS 1092
+EH +KL ++ LR I+ + ++ +++ L E L +++L+++LK LVS
Sbjct: 1804 LEHDEKLVSYLSLLRNIEMRTKQIQP----LELNLAELQDLLCQAKVLERELKDLTTLVS 1859
Query: 1093 -DIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD----HMCQQVYARKEA 1147
+++ + + S + +A + A L+ L ++ W+ H V K
Sbjct: 1860 QELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTK 1919
Query: 1148 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKEEAQQK 1206
+ L + L+ L ++ W+ + + D L +++ + K+ ++
Sbjct: 1920 V---LNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAER 1976
Query: 1207 EAKVKLLTESVNSVIAQ----APPVAQEALKKELETLTTNYQWLCTRLNGK--------- 1253
+A++ L + I++ P + + L L ++Q + + +
Sbjct: 1977 KAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQ 2036
Query: 1254 -------CKTLEEVWACWHELLSYLEKANKWLNEVEFKL-----KTTENIPGGAEEISEV 1301
KTL++ H+ LE W+ + E L +TT+ +++S +
Sbjct: 2037 QMEQEALVKTLQKQQNTCHQ---QLEDLCSWVGQAERALAGHQGRTTQ------QDLSAL 2087
Query: 1302 LDSLENLMRHSEDNPNQIRILAQTLTD-GGVMDE-----------LINEELETFNSRWRE 1349
+ +L +D N+ A + D G M+E + E+L ++
Sbjct: 2088 QKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEA 2147
Query: 1350 LHEEAVRRQKLLEQSIQSA--QETEKS--LHLIQESLTFIDKQLAAYIADKVDAAQMPQE 1405
L EE QK LE+++ SA QETEKS + E+ ID L + Q+
Sbjct: 2148 LQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTN 2207
Query: 1406 AQKIQ--SDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANF 1463
++ S + + +L+ + +A +++ Q ++ + + Q+ L + NF
Sbjct: 2208 LPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQE------LLSQQQNF 2261
Query: 1464 EQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1523
Q ++ LD+ +L E + ++Q++ + + + +L +S +E+K
Sbjct: 2262 ILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ---------- 2311
Query: 1524 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1583
VQ Q E K L + KE WL
Sbjct: 2312 --VQTLQDELQKFLQD---------------------------------HKEFE---SWL 2333
Query: 1584 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTV-----L 1638
++ EL P L S + + +++ K L+ +T G+ + +
Sbjct: 2334 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 2393
Query: 1639 GKKET----LVEDKLSLLNSNWIAVTS---RAEEWLNLLLEYQKHMETFDQNVDHITKWI 1691
GK+ + LV+DKL + A+ S R LN+LL Q H F + D + W+
Sbjct: 2394 GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLG-QYHQ--FQNSADSLQAWM 2450
Query: 1692 ----IQADTLLDESEKKKP---QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG-- 1742
+ LL ++ P Q++ K+L+ EL + + V+ + A ++M G
Sbjct: 2451 QACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEP 2510
Query: 1743 --DHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQG 1800
DH R + E S L+H F ++S+ + ++S+ K + Q Q + E LE+ +Q
Sbjct: 2511 APDH-RHVQETTDSILSH-FQSLSYSL-AERSSLLQKAIAQ----SQSVQESLESLLQSI 2563
Query: 1801 VNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1860
+++ K ++ + G ++E L L+Q I ++ E ++ + + A
Sbjct: 2564 GEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLE-ATREMVTRFMETADSTT 2622
Query: 1861 RSQRRKKALEISHQWYQ---------------------YKRQADDLLKCLDDIEKKLASL 1899
+ + K E+S ++ Q ++ + L + +++ + LAS
Sbjct: 2623 AAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASG 2682
Query: 1900 PEPRDE-----RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAV------------E 1942
+P + ++I+E++ E++ ++E L+ + LS G A+ + +
Sbjct: 2683 NQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKD 2742
Query: 1943 PTQIQLSKRWREIESKFAQ-----FRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 1997
T++Q + + RE ++ Q FR+L + T ++ P E S
Sbjct: 2743 FTELQKTVKEREKDASSCQEQLDEFRKL----VRTFQKWLKETEGSIPPTETSMSAKELE 2798
Query: 1998 TEITHVSQALLEVEQLLNAPDLCAKD--FEDLFKQEESLKNI------KDSLQQSSGRID 2049
+I H+ L D +K E++ + SL+N+ DS ++ +
Sbjct: 2799 KQIEHLKSLL---------DDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILP 2849
Query: 2050 IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI 2109
+ S + T + ++Q +S ++ ++EK+ + +RQ + + H +
Sbjct: 2850 SVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEA 2909
Query: 2110 KIFNQWLTEAEQFLRKTQI---PENWEHAK-----YKWYLKELQDGIGQRQTVVRTLNAT 2161
QWL E+ L+ P E K K +L EL+ + Q V L
Sbjct: 2910 NSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL 2969
Query: 2162 GEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVL 2221
++ + +A ++ LN RW+ + R+++LEE + L+ FQ ++
Sbjct: 2970 ---LVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRP 3026
Query: 2222 WLEEADNIASI--PLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI 2279
WL E + + + PL L + +QV+ +++E R+ +QLNE +L
Sbjct: 3027 WLMEKELMMGVLGPLSI-DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGD 3085
Query: 2280 SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLW 2339
+++ +L+ N +W++++ L + +I+ I Q ++ L+DL E++ +
Sbjct: 3086 VSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQR 3145
Query: 2340 LSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKL 2399
LS Q I QP AV+ + + EI S + L E Q + +L
Sbjct: 3146 LSV---QSAISTQPE------------AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDEL 3190
Query: 2400 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2459
L E + L + L +TV L Q + ++ A ++ +
Sbjct: 3191 SVLIGEQYLKDELKKRL-------------------ETVALPLQGL--EDLAADRI---N 3226
Query: 2460 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2519
L + + F + + EL WL + LE + + + + + L Q
Sbjct: 3227 RLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQH 3286
Query: 2520 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2579
E ++ ++L E + + +++ ++N W+E+ + +R+ +L + ++ +
Sbjct: 3287 SGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQ 3346
Query: 2580 QWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ--KKITETKQLAKDLRQWQTNVDVAN 2637
++ E+ + +AK+ + T+D +Q + +K + ++ + ++ +++ N
Sbjct: 3347 KYQWHVEDLVPWIEDCKAKMSELR---VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILN 3403
Query: 2638 DLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKF 2697
A L+ AD+ + IN + ++ + + + +LEE + L++F E F
Sbjct: 3404 SAADILINSSEADED-GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQ---ESF 3459
Query: 2698 LAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQK 2757
+ E + L+ +K +++L Q + LQ +E D N +Q
Sbjct: 3460 KNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQA-LEPQVDYLRNF---TQG 3515
Query: 2758 ILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWL 2817
++ DA L + + ++ E++++ + +E + + H ++E+ L
Sbjct: 3516 LVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQL 3575
Query: 2818 QLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGL 2877
DDEL IG D ++Q Q +E VR+FL + + L
Sbjct: 3576 ADLDDELDGMGAIGRDTDSLQSQ---------------------IEDVRLFLNKIHVLKL 3614
Query: 2878 --EKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQEL 2935
E E R + EE ++ L+++ E +N + KL Q +++ TL R+++
Sbjct: 3615 DIEASEAECRHMLEEEGTLDLLG-LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDF 3673
Query: 2936 QEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGE-IAPLKENVSHVNDL 2994
L+ AE + VG ++ + L K + E + PL+ + VN L
Sbjct: 3674 YRKLKGLNDATTAAEEAEALQWVVG-TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGL 3732
Query: 2995 ARQL-TTLGIQLSPYNLS-TLEDLNTRWKLLQVAVEDRVRQLHEA 3037
+ L + G L +E++N RW L V R+ QL EA
Sbjct: 3733 GQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEA 3777
Score = 194 bits (492), Expect = 2e-48
Identities = 469/2759 (16%), Positives = 1097/2759 (39%), Gaps = 318/2759 (11%)
Query: 450 NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 509
++KL L E RT++++ PL +L +L+ + Q KVL+ +L+ V+
Sbjct: 1807 DEKLVSYLSLLRNIEMRTKQIQ--PLELNLAELQDLLCQAKVLERELKDLTTLVSQELEC 1864
Query: 510 VVVVDESSGDHATA----ALEEQLKVLGDRWANICRWTEDRWVLLQD--------ILLKW 557
V + S A ALE+ K L +++ R + Q+ +L +
Sbjct: 1865 VNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQH 1924
Query: 558 QRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLY 617
+L AW+ K +N + D + + LQ+ LK + ++K + L
Sbjct: 1925 TQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALA 1984
Query: 618 SLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS-----------QAVT 666
Q +S Q+ L + LE++ AQ+ +A+
Sbjct: 1985 FDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALV 2044
Query: 667 TT---QPSLTQTTVMETVTTVTTREQILVKH----AQEELPPPPPQKKRQITVDSEIRKR 719
T Q + + + + V E+ L H Q++L + + +I+ R
Sbjct: 2045 KTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNR 2104
Query: 720 LDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRS 779
T + + E ++ + + +E + L+EK++ + E++ LQ+ +R
Sbjct: 2105 A----TSFATVVKDIEGFMEENQTKLSPRE--LTALREKLH----QAKEQYEALQEETRV 2154
Query: 780 AQALVEQMVNEGVNADSIK-QASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FYNQLQQ 837
AQ +E+ V + ++ K +A+++L E + + L+W+ + L
Sbjct: 2155 AQKELEEAVTSALQQETEKSKAAKEL----AENKKKIDALLDWVTSVGSSGGQLLTNLPG 2210
Query: 838 LEQMTTTAENWLKIQPT-----TPSEPTAIKSQLKICKDEVNRLSGLQPQ-IERLKIQSI 891
+EQ++ + + T P + Q ++ K L Q I +
Sbjct: 2211 MEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQA 2270
Query: 892 ALKEKGQG-----PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSA 946
L + G L + + +A K++QT+ D L ++ +
Sbjct: 2271 FLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDEL--QKFLQDHKE 2328
Query: 947 IRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEM---- 1002
+W+++SE +L + E + L + + + L +++ + +++
Sbjct: 2329 FESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDME 2388
Query: 1003 ----SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKK 1058
K PSEI + + ++ R+ L S+ L + + + QN +L+
Sbjct: 2389 NSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQA 2448
Query: 1059 WM----AEVDVFLKEEWPALGDSEILKKQL---KQCRLLVSDIQTIQPSLNSVNEGGQKI 1111
WM A V+ L + D +L++QL KQ + +++ Q L V +I
Sbjct: 2449 WMQACEANVEKLLSDT--VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEI 2506
Query: 1112 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1171
+ E P+ ET + + + + + R L+ + ++ S+Q+ L + + + +
Sbjct: 2507 EGEPAPDHRHVQETT-DSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGE 2565
Query: 1172 AEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA 1231
E+ + + +Q+A+ + K++ ++++ ++ E V + A
Sbjct: 2566 VEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAV 2625
Query: 1232 LKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENI 1291
L+ +L ++ ++ LC + K +L+++ E+ +L + E + ++ + N
Sbjct: 2626 LQGKLAEVSQRFEQLCLQQQEKESSLKKLLP-QAEMFEHLSGKLQQFMENKSRMLASGNQ 2684
Query: 1292 PGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD----GGVMDELINEE-LETFNSR 1346
P ++I+ ++ L ED + L +T+ G +D +++ ++
Sbjct: 2685 PD--QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKD 2742
Query: 1347 WRELHEEAVRRQK--------------LLEQSIQSAQETEKSLHLIQESLTF--IDKQLA 1390
+ EL + R+K L+ + +ETE S+ + S++ ++KQ+
Sbjct: 2743 FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIE 2802
Query: 1391 AYIADKVDAAQMPQEAQKIQSDLTSHE-ISLEEMKKHNQGKEAA--------------QR 1435
+ D A ++I TS E + +E +QGK +
Sbjct: 2803 HLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH 2862
Query: 1436 VLSQIDVAQKKLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPALETKS-- 1488
+ Q + DV++K+ L ++ + + L + + E L LE+K
Sbjct: 2863 TCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEV 2922
Query: 1489 ----------VEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV----QKKQTENP 1534
+ E V++Q L + +++ V + ++ ++ EN
Sbjct: 2923 LKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENW 2982
Query: 1535 KELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRS 1594
K++ E + + E+ R++QLE+ + + L WL ++ +
Sbjct: 2983 KKIQEELNSRWERATEV---TVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLG 3039
Query: 1595 AVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGK---KETLVEDKLSL 1651
+ P+ L+++ + KE E ++ + + E + + T G + V+ +L
Sbjct: 3040 PLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQS 3099
Query: 1652 LNSNWIAVT-------SRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKK 1704
+N W+ +T S+ ++ + +YQ+ ++ + V + + + + + E
Sbjct: 3100 INQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAV 3159
Query: 1705 KPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG-----DHCRKLVEPQISELNHR 1759
K Q +E ++++L + +V + L G D +K +E L
Sbjct: 3160 KQQLEET--SEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGL 3217
Query: 1760 FAAISHRIKTGKASIP-LKELEQFNSDIQKLLE----------PLEAEIQ--QGVNLKEE 1806
+ RI +A++ ++ +Q +++ L+ P+ A+++ Q + E
Sbjct: 3218 EDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENE 3277
Query: 1807 DFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRK 1866
+F K +N+ + G+ + ++ G++L + ++ ++ + L+ L + R+
Sbjct: 3278 EFQKSLNQ-HSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQS 3336
Query: 1867 KALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVR 1926
+ + + +Y+ +DL+ ++D + K++ L D +++ L + K LN V
Sbjct: 3337 RLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDP---VQLESSLLRSKAMLNEVE 3393
Query: 1927 RQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMP 1986
++ L +A + + + I + A + A ++ +T + E+M
Sbjct: 3394 KRRSLLEILNSAADILINSSEADEDG--IRDEKAGINQNMDAVTEELQAKTGSL--EEMT 3449
Query: 1987 LEISYVPSTYLTEITHVSQAL--LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQS 2044
+ ++ V A LE+ L + K+ E L Q+E L+ ++
Sbjct: 3450 QRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP----- 3504
Query: 2045 SGRIDIIHSKKTAALQSA---TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEK 2101
++D + + ++ A + ++ Q ++Q +F +V + + +E
Sbjct: 3505 --QVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL--EVKQRVNSGCVMMENKLEG 3560
Query: 2102 WRRFHYDIK-IFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNA 2160
+FH ++ +F+Q ++ I + + + + +++++ + + + + A
Sbjct: 3561 IGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQ--IEDVRLFLNKIHVLKLDIEA 3618
Query: 2161 TGEE---IIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNI----LSEFQ 2213
+ E ++++ D L+ +L +LN + C +L++R K +EQ + + +F
Sbjct: 3619 SEAECRHMLEEEGTLDLLGLKRELEALNKQ----CGKLTERGKARQEQLELTLGRVEDFY 3674
Query: 2214 RDL---NEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL--PLRQGILKQLN 2267
R L N+ EEA+ + + G E ++ ++L K+ +E PL+ L+Q+N
Sbjct: 3675 RKLKGLNDATTAAEEAEALQWVV---GTEVEIINQQLADFKMFQKEQVDPLQMK-LQQVN 3730
Query: 2268 ETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLE 2327
G ++ SA + Q LE+ +++ N +W +++ + ++ +++ + G+ + LE
Sbjct: 3731 GLGQGLIQSAGKDCDVQG-LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALE 3789
Query: 2328 DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPF---DVQETEIA---VQAKQPDVEEILSK 2381
L L WL+ + P+ E +QE ++ + ++ V+ + ++
Sbjct: 3790 PL-------LSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAE 3842
Query: 2382 GQHLYK--EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT 2439
G + + E + + +LE L S W LL + A+Q L L
Sbjct: 3843 GGRIAQSAELADREKITGQLESLESRW---TELLSKAAARQKQLEDIL------------ 3887
Query: 2440 LVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDL 2499
V+ K+ F+ ++D+LS+ ++ + + +
Sbjct: 3888 -----VLAKQ---------------------FHETAEPISDFLSVTEKKLANSEPVGTQT 3921
Query: 2500 EDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDE 2559
I + II+ KA +D+E + + + Q+L + TS E + +++++I+ +Q ++ E
Sbjct: 3922 AKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE-QGVLSEKIDSLQARYSE 3980
Query: 2560 VQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITET 2619
+Q+ + L++ L ++ + E + E L + KL S + D + ++ +
Sbjct: 3981 IQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADH 4040
Query: 2620 KQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAA 2679
L +++ + NVD A LL+ + ++ + + I + I S+
Sbjct: 4041 LALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRT 4100
Query: 2680 LEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQG 2739
LE+ +L +F E+ WL E E ++ + + + ++ ++L+
Sbjct: 4101 LEQARQLATKFQSTYEELTGWLREVE------EELATSGGQSPTGEQIPQFQQRQKELKK 4154
Query: 2740 EIEAHTDVYHNLDENSQKIL-----RSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRS 2794
E+ H V ++E S+ +L R+ EG D V + N ++ +
Sbjct: 4155 EVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLV------SDANEQYKLVSDTIGQRVD 4208
Query: 2795 HLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTK 2854
++A+ + ++ + L W+ +L PI + Q V +AF
Sbjct: 4209 EIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAF------- 4261
Query: 2855 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 2914
+++ +R + +++L+ E+ + T +L+++ E + ++E +
Sbjct: 4262 ------SIDIIR------HKDSMDELFSHRSEIFGTCGEEQKT-VLQEKTESLIQQYEAI 4308
Query: 2915 NLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKV 2974
+L +++ +++ + + E +EL + + + P + + L+ E++
Sbjct: 4309 SLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQ-LPSPAIDHEQLRQQQEEM 4367
Query: 2975 KALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQ 3033
+ LR IA K ++ + + QL +L+P +E+ + + + +++ VRQ
Sbjct: 4368 RQLRESIAEHKPHIDKLLKIGPQLK----ELNPEEGEMVEEKYQKAENMYAQIKEEVRQ 4422
Score = 184 bits (467), Expect = 1e-45
Identities = 361/1991 (18%), Positives = 773/1991 (38%), Gaps = 283/1991 (14%)
Query: 328 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 387
+ L E+ ++ ++Q ALE +LSWL E+ + Q S + +VVK Q + L
Sbjct: 3772 AQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDD 3831
Query: 388 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECL--RVASMEKQSNLHRVL 445
+ V + G ++ + +L++ E+ + Q+ L SRW L + A+ +KQ VL
Sbjct: 3832 RKATVDMLQAEGGRIAQSAELADREK--ITGQLESLESRWTELLSKAAARQKQLEDILVL 3889
Query: 446 MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 505
++ + ++D+L+ TE++ EP+G +++Q+ +HK L+ED+E V+
Sbjct: 3890 AKQFHETAEPISDFLSVTEKKLAN--SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3947
Query: 506 LTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQC 565
+ + + L E++ L R++ I + LL L + E++
Sbjct: 3948 AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEV 4007
Query: 566 LFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLS 625
WL+E ED ++ + FK LA L ++ +K+++ + Q LL
Sbjct: 4008 EVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLA-LNEEIVNRKKNVDQAIKNGQALLK 4066
Query: 626 TLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVT 685
+ V E D + + T S+A+ T + + T ++
Sbjct: 4067 QTTGEEVLLIQEKL--------DGIKTRYADITVTSSKALRTLEQARQLATKFQS----- 4113
Query: 686 TREQIL--VKHAQEELPPPPPQKK--RQITVDSEIRKRLDVDITELHSWI--TRSEAVLQ 739
T E++ ++ +EEL Q QI + +K L ++ E H + T +E
Sbjct: 4114 TYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVME-HRLVLDTVNEVSRA 4172
Query: 740 SPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQ 799
E +R L N E+++ + D + Q V+E D+ Q
Sbjct: 4173 LLELVPWRAREGLDKLVSDAN-------EQYKLVSDT-------IGQRVDE---IDAAIQ 4215
Query: 800 ASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEP 859
S+Q Q L W+ + ++ LEQ TTA+ L++Q
Sbjct: 4216 RSQQYE-------QAADAELAWVAETKRKLMALGPIR-LEQDQTTAQ--LQVQK------ 4259
Query: 860 TAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQV 917
A + KD ++ L + +I + Q L+EK + + + ++ N
Sbjct: 4260 -AFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTES-LIQQYEAISLLN----- 4312
Query: 918 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 977
S+ AR + Q + + ++ ET + W++++ ++ D+E + Q+ E
Sbjct: 4313 -SERYARLERAQVLVN-----QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEE 4366
Query: 978 LQALQSSLQEQQ---SGLYYLSTTVKEMSKKAPSEISRKYQSEF-------EEIEGRWKK 1027
++ L+ S+ E + L + +KE++ + + KYQ EE+ R
Sbjct: 4367 MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALA 4426
Query: 1028 L------SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILK 1081
L S+Q+ E K+E + L + + ++ AEVD ++
Sbjct: 4427 LDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDK--------------IR 4472
Query: 1082 KQLKQCRLLVSDIQTIQPSLNSVNEGGQKI---KNEAEPEFASR-LETELKELNTQWDHM 1137
+ + + +++ +QPS ++ G+++ A+ + A++ ++ +L ++ W+ +
Sbjct: 4473 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4532
Query: 1138 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1197
+ R+ LE D++ + + ++ + + P +++ VE +
Sbjct: 4533 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4592
Query: 1198 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1257
KEE +++ + +I + ++K ++ + ++ L + + L
Sbjct: 4593 TIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKL 4652
Query: 1258 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1317
E+ + L+ WL+ KL T +P +++ V D L N M+ +
Sbjct: 4653 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCT---MPPVGTDLNTVKDQL-NEMKEFKVEVY 4708
Query: 1318 QIRILAQTLTDGGVM----------DELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1367
Q +I + L G + ++I E L W L E+ RQ LE ++ +
Sbjct: 4709 QQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLA 4768
Query: 1368 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMK 1424
+ + +L + LT ++ L A D + E K +++D+ +H+ ++E +
Sbjct: 4769 LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4828
Query: 1425 K------HNQGKEAAQRVLSQIDVAQKKLQDVSMKFR--------LFQKPANFEQRLQES 1470
K + + A + S+++ + + V K Q+ F +++
Sbjct: 4829 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDF 4888
Query: 1471 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR-QIVQKK 1529
+ L ++ L A + E + QL+ + LY L + ++ GR ++ +
Sbjct: 4889 LLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRD 4948
Query: 1530 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1589
+ + + ++ V L+ ++ + +K+ ERK +LE+ L L+ + + + WL +
Sbjct: 4949 DSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQS 5008
Query: 1590 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-LVEDK 1648
L S + + + S++ K E+ + + + + G LK + K++ L+++
Sbjct: 5009 LNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNL 5068
Query: 1649 LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQ 1708
L + S W V R+ I+ LD++ +K+ +Q
Sbjct: 5069 LVSVQSRWEKVVQRS----------------------------IERGRSLDDA-RKRAKQ 5099
Query: 1709 KEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIK 1768
+ K+L L D +DS + ++N D
Sbjct: 5100 FHEAWKKLIDWLEDAESHLDSELE-----ISNDPD------------------------- 5129
Query: 1769 TGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGD 1828
K + L + ++F + + I+ G LKE+ + ++ + + E+ + D
Sbjct: 5130 --KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWD 5187
Query: 1829 NLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQW-YQYKRQADDLLK 1887
+ + + + + E + L S + AL+ W Y+ + Q +
Sbjct: 5188 TVCGKSVERQHKLEEAL--------------LFSGQFMDALQALVDWLYKVEPQLAEDQP 5233
Query: 1888 CLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA--AMAVEPTQ 1945
D++ + + D K+ +EL K+ + ++R L E+ V+
Sbjct: 5234 VHGDLDLVMNLM----DAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQL 5287
Query: 1946 IQLSKRWREI-ESKFAQFRRLNFA--QIHTVREETMMVMTEDMPLEISYVPSTYLTEITH 2002
+LS RW + + ++ RL A Q R+ M++ E + L + T
Sbjct: 5288 QELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTE 5347
Query: 2003 VSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 2062
Q+L++ + E + K EE ++ ++ + + H ++
Sbjct: 5348 ALQSLIDTHK------------EFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHW 5395
Query: 2063 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2122
+ R + +E L+ W K Q R + ++ + ++ W+ AE
Sbjct: 5396 ITIIRARFEEVLT-----WAK------QHQQRLETALSELVANAELLEELLAWIQWAETT 5444
Query: 2123 LRKTQ---IPENWEHAK-----YKWYLKELQDGIGQRQTVVRTLN--------------- 2159
L + IP+N + K ++ +++E+ V +T
Sbjct: 5445 LIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKS 5504
Query: 2160 -ATGEEIIQQSSKTDASILQE------KLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEF 2212
+ G + + Q + IL + ++ L+ RWQ+V +R+++L + + L E
Sbjct: 5505 RSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEEL 5564
Query: 2213 QRDLN-EFVLW 2222
+ N +F +W
Sbjct: 5565 KEFANFDFDVW 5575
Score = 91.3 bits (225), Expect = 2e-17
Identities = 111/555 (20%), Positives = 233/555 (41%), Gaps = 31/555 (5%)
Query: 327 GSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLT 386
G SL ++ ++ A ++++ WL AE L ++ EISND + +K Q H+ + L
Sbjct: 5087 GRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLG 5146
Query: 387 AHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 446
Q ++ G L L ED + ++ + + +W+ + S+E+Q L L+
Sbjct: 5147 GKQPVYDTTIRTGRALKEKTLLPEDSQ-KLDNFLGEVRDKWDTVCGKSVERQHKLEEALL 5205
Query: 447 DLQN--QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 504
L+ L DWL K E + E++P+ DL+ + + HKV Q++L + V
Sbjct: 5206 FSGQFMDALQALVDWLYKVEPQL--AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQ 5263
Query: 505 SLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 564
L + E+S D T ++ QL+ L RW +C+ + + L+ L + + +
Sbjct: 5264 VLKRSGRELIENSRDD-TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTV 5322
Query: 565 CLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSL-QKLAVLKADLEKKKQSMGKLYSLKQDL 623
+ WLSE E + D E L SL +E+K+ + ++ + +
Sbjct: 5323 HMLLEWLSEAEQTLR--FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVI 5380
Query: 624 LSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTT 683
L+ +T + W+ ++ ++ ++ ++ A+ ++ + E +
Sbjct: 5381 LAVCHPDCIT-TIKHWITIIRARFEEVLTWAKQHQQRLETAL--SELVANAELLEELLAW 5437
Query: 684 VTTREQILVKHAQEELPPPPPQKK-----RQITVDSEIRKRLDVD-ITELHSWITRSEAV 737
+ E L++ QE +P + K Q ++ RK+ DVD +T+ + R
Sbjct: 5438 IQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYK---RKNIE 5494
Query: 738 LQSPEFAIFRKEGNFSDLKE----KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVN 793
F + G L + + + + +A+ R Q ++R Q + + +
Sbjct: 5495 PTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKL 5554
Query: 794 ADSIKQASEQLNSRWIEFCQLLSERLNWLEY-QNNIIAFYNQLQQLEQMTTTAENWL--- 849
D++ + E +F + + W+ + ++ ++ F+ ++ + + T + ++
Sbjct: 5555 NDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGI 5614
Query: 850 --KIQPTTPSEPTAI 862
PTT E TA+
Sbjct: 5615 LASKFPTTKLEMTAV 5629
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 370 bits (950), Expect = e-101
Identities = 574/2872 (19%), Positives = 1190/2872 (41%), Gaps = 335/2872 (11%)
Query: 324 KSFGSSLMESEVNLDRYQTA-----LEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTH 378
++F L E+E ++ +T+ LE+ + L S D ++G + VE + + +
Sbjct: 2270 RTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTL---VEEINCKGTSL 2326
Query: 379 EGYMMDLTA--HQGRVGNILQLGSKLIGT--GKLSEDEETEVQEQMNLLNSRWECLRVAS 434
E +M++TA QG+ G+IL +G+ G + + TE+Q M+ +N ++E L
Sbjct: 2327 ENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVL 2386
Query: 435 MEKQSNLHRVL--MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVL 492
E+Q +L +L M+ +++ + WL EE + M+ E +K Q + +K
Sbjct: 2387 HERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAF 2446
Query: 493 QEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQD 552
+LEQ ++ V + +G T ++ + W I RW +
Sbjct: 2447 LAELEQNSPKIQK------VKEALAGLLVTYPNSQE----AENWKKIQEELNSRWERATE 2496
Query: 553 ILLKWQRLTEEQ-----CLFSA------WLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAV 601
+ + QR EE C +A WL EKE + + D N + + Q++
Sbjct: 2497 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI-DPNMLNAQKQQVQF 2555
Query: 602 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSV-TQKTEAWLDNFARCWDNLVQKLEKSTAQ 660
+ + E ++Q +L Q +L+ + S+ T + + L + + W L KL ++Q
Sbjct: 2556 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ 2615
Query: 661 ISQAVT-TTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIR-- 717
I QA+ +TQ + E V V R + Q + P K+Q+ SEIR
Sbjct: 2616 IDQAIVKSTQYQELLQDLSEKVRAVGQRLSV-----QSAISTQPEAVKQQLEETSEIRSD 2670
Query: 718 -KRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDA 776
++LD ++ E + + +VL ++ + + + +E A++ +LQ A
Sbjct: 2671 LEQLDHEVKEAQT-LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAA 2729
Query: 777 SRSAQALVEQMVNEGVNADSIKQAS-----------EQLNSRWIE---FCQLLSERLNWL 822
S Q +QM +E KQ+ E+L S+ E F + L++
Sbjct: 2730 LASTQQF-QQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSY 2788
Query: 823 EY---------------------QNNIIAFYNQLQQLEQMTTTAENWLK----------- 850
E QN ++ N ++L + T ++ LK
Sbjct: 2789 EVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW 2848
Query: 851 -IQPTTP--SEPTAIKSQLKICKDEVNRLSGL---QPQIERLKIQSIALKEKGQGPMFL- 903
++ P + A S+L++ D V S L + + ++ + L+ L
Sbjct: 2849 HVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILI 2908
Query: 904 ---DADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPM-----RYQETMSAIRTWVQQSE 955
+AD + + ++ A +ELQ +L M +QE+ I V+ ++
Sbjct: 2909 NSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAK 2968
Query: 956 TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP--SEISRK 1013
+L I ++ + L +L+A Q LQ + + YL + + + AP S+ S+
Sbjct: 2969 HQLEIFD-ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQL 3027
Query: 1014 -YQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 1072
+Q+E + E + ++ ++ C +E ++ + + ++ + +A++D L
Sbjct: 3028 LHQAEVAQQE--FLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGA 3085
Query: 1073 ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNT 1132
D++ L+ Q++ RL ++ I ++ + + + + E L+ EL+ LN
Sbjct: 3086 IGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNK 3145
Query: 1133 QWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEE-EYLERDFEYKTPDELQK 1191
Q + ++ AR+E L+ L + + L +++ T AEE E L+ + Q+
Sbjct: 3146 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205
Query: 1192 AVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ-EALKKELETLTTNYQWLCTRL 1250
+ KE+ + K++ + +I A + L+ ++E + + L ++
Sbjct: 3206 LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKV 3265
Query: 1251 NGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMR 1310
+ L+E + LE WL + E + + + + + + L R
Sbjct: 3266 AQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQR 3325
Query: 1311 HSEDNPNQIRILAQTLTDGGVMD--------ELINEELETFNSRWRELHEEAVRRQKLLE 1362
+D + +L +GG + E I +LE+ SRW EL +A RQK LE
Sbjct: 3326 LLDDRKATVDMLQ---AEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3382
Query: 1363 QSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEA---QKIQSDLTSHEIS 1419
+ A++ ++ I + L+ +K+LA A++ Q+ + ++ D+ +H
Sbjct: 3383 DILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATD 3442
Query: 1420 LEEMKKHNQG-----KEAAQRVLSQ-IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1473
+ + K Q A Q VLS+ ID Q + ++ + R +K A +Q L +++
Sbjct: 3443 VHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEI--QDRCCRKAALLDQALSNARLF 3500
Query: 1474 ----------LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1523
L EV+ L ++ K +Q+V+ Q + L + + K V+ IK G+
Sbjct: 3501 GEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQ 3560
Query: 1524 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1583
++++ E + E++ +K Y ++ ++ + LE+ +L+ K + LT WL
Sbjct: 3561 ALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWL 3620
Query: 1584 AATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQ----KVHLKSITEVGEALKTVLG 1639
+ EL A G S ++ + QKE++K+ ++ L ++ EV AL ++
Sbjct: 3621 REVEEEL----ATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVP 3676
Query: 1640 KKETLVEDKL-SLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL 1698
+ DKL S N + V+ + ++ + + + ++Q D W+ + L
Sbjct: 3677 WRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKL 3736
Query: 1699 D-----ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI 1753
E+ + + V K ++ + +D + + G+ + +++ +
Sbjct: 3737 MALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKT 3796
Query: 1754 SELNHRFAAIS-----HRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQ--GVNLKEE 1806
L ++ AIS + +A + + + + ++ +E A I Q + E
Sbjct: 3797 ESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHE 3856
Query: 1807 DFNKDMNE---------DNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNAL 1857
+ E +++ + +LL+ G L+ E EE ++ ++ Q N
Sbjct: 3857 QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLK-----ELNPEEGEMVEEKYQKAENMY 3911
Query: 1858 KDLRSQRRKKALEI------SHQWYQYKRQADDLLKCLDDIEKKLASLPE-PRDERKIKE 1910
++ + R++AL + S Q ++ + + +L+ L+++ +L P P + KI+E
Sbjct: 3912 AQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE 3971
Query: 1911 IDR-------ELQKKKEELNAVRRQAE-------GLSEDGAAMAVEPTQIQLSKRWREIE 1956
EL+K + A++R+ E G +D AA ++ Q+ W +I+
Sbjct: 3972 CISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIK 4031
Query: 1957 SKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNA 2016
++ A+ R + F + + E+ Y + LT I + ++E
Sbjct: 4032 AR-AEEREIKFLDVLELAEKFW------------YDMAALLTTIKDTQDIVHDLESPGID 4078
Query: 2017 PDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQ 2076
P + + +Q E+ + IK+ ++ I + + E+ ++++++ +
Sbjct: 4079 PSI-------IKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDE 4131
Query: 2077 LDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAK 2136
++ WE +NK +K+R + + +++ ++ ++ WL L T P +
Sbjct: 4132 MNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLC-TMPPVGTDLNT 4190
Query: 2137 YKWYLKELQD---GIGQRQTVVRTLNATGEEIIQQSS-KTDASILQEKLGSLNLRWQEVC 2192
K L E+++ + Q+Q + LN GE ++++++ +TD I++E L L W+ +
Sbjct: 4191 VKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLG 4250
Query: 2193 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNI--ASIPLEPGKEQQLKEKLEQVK 2250
++++ R+ +LE L +FQ L E + WL + + A P+ G + ++ +L +
Sbjct: 4251 EKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPIS-GDPKVIEVELAKHH 4309
Query: 2251 LLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ- 2309
+L ++ Q ++ +N+ G +L S+ + ++ L ++L+ N W V + E++
Sbjct: 4310 VLKNDVLAHQATVETVNKAGNELLESS--AGDDASSLRSRLEAMNQCWESVLQKTEEREQ 4367
Query: 2310 -------------GEIEAQIKDLGQLEKKL----------EDLEEQLNHLLLWLSPIRNQ 2346
EIE + +L ++E +L E EQL+ + S ++ +
Sbjct: 4368 QLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAK 4427
Query: 2347 LEIYNQPNQEGPFDV-QETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLED---L 2402
E YNQ +G + + +K +L + H+ K + K KLE+ L
Sbjct: 4428 EETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEER--KSKLEEALNL 4485
Query: 2403 SSEWK-------------------------AVNRLLQELRAKQP---------DLAPGLT 2428
++E++ +N +L ++ + D L
Sbjct: 4486 ATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELD 4545
Query: 2429 TIG-----ASPTQTVTLVTQPVVTKETAISK-----LEMPSSLMLEVPALADFNRAWTEL 2478
G S Q V L+ +V+ ++ K +E SL F+ AW +L
Sbjct: 4546 QTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKL 4605
Query: 2479 TDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTS 2538
DWL + + S+ + D + I + K K + L ++P + I + LK KT
Sbjct: 4606 IDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTL 4665
Query: 2539 NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAK 2598
E + + + ++++WD V R+ +L E L S Q+++A + L + +
Sbjct: 4666 LPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQ 4725
Query: 2599 LESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMI 2658
L + +D + + K K+L + V V +L+ + S DDT V
Sbjct: 4726 LAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-SRDDTTWVKGQ 4784
Query: 2659 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT---ANVLQDAT 2715
+ ++ W ++ K +++ LE+ + + F + L WL+EAE T L D T
Sbjct: 4785 LQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDT 4844
Query: 2716 RKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRL 2775
+ L D+ KE MK+ ++ + ++ + + +++ ++ D ++ +
Sbjct: 4845 EALQSLIDTH--KEFMKKVEEKRVDVNSAVAM--------GEVILAVCHPDCITTIKHWI 4894
Query: 2776 DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGD 2833
+ ++ E+ + + LE + + L+ELL W+Q + L + Q PI +
Sbjct: 4895 TIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQN 4954
Query: 2834 FPAVQKQNDVHRAFKRELKTKEPVI--------MSTLETVRIFLTEQPLEGLEKLYQEPR 2885
V+ H+ F E+ K+P + +E E+ G K +P
Sbjct: 4955 IDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQP- 5013
Query: 2886 ELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2937
PP + + + +++ W+++ L + + QRK+++ L+RL+EL+E
Sbjct: 5014 -TPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5064
Score = 351 bits (900), Expect = 9e-96
Identities = 526/2787 (18%), Positives = 1138/2787 (40%), Gaps = 333/2787 (11%)
Query: 380 GYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQS 439
G+ +DL HQ RV N+ + ++L T K E + + QEQ++ + E +
Sbjct: 2222 GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEG 2281
Query: 440 NLHRVLMDLQNQKLKE--------LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 491
++ + ++L++ L+DW +K T E G LE+L +
Sbjct: 2282 SIPPTETSMSAKELEKQIEHLKSLLDDWASKG---TLVEEINCKGTSLENL--------I 2330
Query: 492 LQEDLEQEQVRVNSLTHMV-VVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRW 547
++ Q + S+ V V +G H L E + D ++ + +R
Sbjct: 2331 MEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQ 2390
Query: 548 VLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLE 607
LQ IL + + + +E WL KE+ + + + E + + + KA L
Sbjct: 2391 ESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESN--KAFLA 2448
Query: 608 KKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 667
+ +Q+ K+ +K+ L L +Q+ E W +I + + +
Sbjct: 2449 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENW-------------------KKIQEELNS 2489
Query: 668 TQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITEL 727
T+ TV ++RQ+ + ++L
Sbjct: 2490 RWERATEVTVA---------------------------RQRQLEESASHLACFQAAESQL 2522
Query: 728 HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQM 787
W+ E ++ + + K++V + +E + ++ + + +AQ ++
Sbjct: 2523 RPWLMEKE-LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGP 2581
Query: 788 VNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQL-QQLEQMTTTAE 846
+ ++ +++ + +N +W+E L+ R + ++ Y +L Q L +
Sbjct: 2582 GDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVG 2641
Query: 847 NWLKIQPTTPSEPTAIKSQLK---------------------ICKDEVNRLSGLQPQIER 885
L +Q ++P A+K QL+ +C DE++ L G Q +
Sbjct: 2642 QRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLC-DELSVLIGEQYLKDE 2700
Query: 886 LK--IQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQET 943
LK ++++AL +G + D N + + Q ++Q+
Sbjct: 2701 LKKRLETVALPLQGLEDLAADR-----INRLQAALASTQ----------------QFQQM 2739
Query: 944 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE-- 1001
+RTW+ +++ + E ++ +L E + Q SL Q SG Y + E
Sbjct: 2740 FDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN-QHSGSYEVIVAEGESL 2798
Query: 1002 MSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMA 1061
+ P E R Q++ E++ W++LS + + +L++ M K +K Q H++ L W+
Sbjct: 2799 LLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIE 2858
Query: 1062 EVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFAS 1121
+ + E L D L+ L + + ++++++ + L +N + N +E +
Sbjct: 2859 DCKAKMSELRVTL-DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEAD-ED 2916
Query: 1122 RLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDF 1181
+ E +N D + +++ A+ +L+ ++ Q+ + + + A+ + LE
Sbjct: 2917 GIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQ-LEIFD 2975
Query: 1182 EYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA-LKKELETLT 1240
+ K +E+++ +E Q E +V L ++ AP + + L + E
Sbjct: 2976 ALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQ 3035
Query: 1241 TNYQWLCTRLNGKCKTLE---EVWACWH----ELLSYLEKANKWLNEVEFKLKTTENIPG 1293
+ + R+N C +E E +H E+ S L + L+ + + T+++
Sbjct: 3036 QEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQS 3095
Query: 1294 GAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDEL-INEELETFNSRWRELHE 1352
E++ L+ + L E + + R + L + G +D L + ELE N + +L E
Sbjct: 3096 QIEDVRLFLNKIHVLKLDIEASEAECRHM---LEEEGTLDLLGLKRELEALNKQCGKLTE 3152
Query: 1353 EAVRRQKLLEQSI-----------------QSAQETEKSLHLIQESLTFIDKQLA---AY 1392
RQ+ LE ++ +A+E E ++ + I++QLA +
Sbjct: 3153 RGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMF 3212
Query: 1393 IADKVDAAQMPQEAQK------IQS-----DLTSHEISLEEMKK--HNQGKEAAQRVLSQ 1439
++VD QM + IQS D+ E +EE+ + K+ AQR+
Sbjct: 3213 QKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA-- 3270
Query: 1440 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1499
+LQ+ + F+ L+ L + + + + S E +VV++Q+
Sbjct: 3271 ------QLQEALLHC------GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ 3318
Query: 1500 HCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERK 1559
L + L + K+ V+M+ G +I Q + + +++ ++ +L+ + EL +K R+
Sbjct: 3319 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3378
Query: 1560 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1619
+QLE L L+++ + ++++L+ T+ +L V + + ++ KA +++IE
Sbjct: 3379 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3438
Query: 1620 QKVHLKSITEVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHME 1678
+ ++G++L ++ E ++ +K+ L + + + R LL + +
Sbjct: 3439 HATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR 3498
Query: 1679 TFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR-------LKAELNDIRPKVDSTR 1731
F ++ + W+ + + L K K+DVL R L E+ + + VD
Sbjct: 3499 LFGEDEVEVLNWLAEVEDKLSSVFVK--DFKQDVLHRQHADHLALNEEIVNRKKNVDQAI 3556
Query: 1732 DQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLE 1791
L+ L++ ++ + R+A I+ + + KA L++ Q + Q E
Sbjct: 3557 KNGQALLKQTTGEEVLLIQEKLDGIKTRYADIT--VTSSKALRTLEQARQLATKFQSTYE 3614
Query: 1792 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1851
L +++ ++EE + + QR L++ + + R + +
Sbjct: 3615 ELTGWLRE---VEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR------LVLDTVN 3665
Query: 1852 TKHNALKDLRSQRRKKALE--ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIK 1909
AL +L R ++ L+ +S QYK +D + + +D+I+ + R ++ +
Sbjct: 3666 EVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQ-----RSQQYEQ 3720
Query: 1910 EIDREL------QKKKEELNAVRRQAEGLSEDGAAMAVEPT-QIQLSKRWREIESKFAQ- 1961
D EL ++K L +R + + + A + V+ I + + ++ F+
Sbjct: 3721 AADAELAWVAETKRKLMALGPIRLEQD---QTTAQLQVQKAFSIDIIRHKDSMDELFSHR 3777
Query: 1962 ---FRRLNFAQIHTVREETMMVMTEDMPLEI------------SYVPSTYLTEITHVSQA 2006
F Q ++E+T ++ + + + + + + +S
Sbjct: 3778 SEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 3837
Query: 2007 LLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVE 2066
+ E L+ A D E L +Q+E ++ +++S+ + ID + K L+ P E
Sbjct: 3838 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKL-LKIGPQLKELNPEE 3896
Query: 2067 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRR---FHYDIKIFNQWLTEAEQFL 2123
++E + + + ++ + + R D +V + + FH I+ + L L
Sbjct: 3897 GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRL 3956
Query: 2124 RKTQ-IPENWEHAKYKWYLKELQDG---IGQRQTVVRTLNATGEEIIQQSSKTDASI--- 2176
R IP E K + + + + + + Q L GEE+I +S D +
Sbjct: 3957 RMPPLIPA--EVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAK 4014
Query: 2177 -LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLE 2235
+Q+KL + W+++ + +R+ + + + +F D+ + +++ +I
Sbjct: 4015 EIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLES 4074
Query: 2236 PGKEQQL-KEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2294
PG + + K+++E + + EE L+ + G ++ + E+ ++ + +
Sbjct: 4075 PGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC--GETEKPEVRKSIDEM 4132
Query: 2295 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS---PIRNQLEIYN 2351
N W +++ E+ ++E ++ Q + L+ + + L++ ++ L P+ L
Sbjct: 4133 NNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVK 4192
Query: 2352 QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNR 2411
E ++E ++ V +Q ++E++ +G+ + K+ AT R + +
Sbjct: 4193 DQLNE----MKEFKVEVYQQQIEMEKLNHQGELMLKK--ATDETDRDI---------IRE 4237
Query: 2412 LLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADF 2471
L EL+ +L ++ A + ++ +L+ AL F
Sbjct: 4238 PLTELKHLWENLG-----------------------EKIAHRQHKLEGALL----ALGQF 4270
Query: 2472 NRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQ 2531
A EL WL+ ++++ +QR + GD + I + K D+ + +E + A
Sbjct: 4271 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4330
Query: 2532 NLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQV 2591
L ++ +A + + R+E + W+ V + + R QQL L+ + + E+
Sbjct: 4331 ELLESSAGDDASS-LRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4389
Query: 2592 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR-QWQTNVDVANDLALKLLRDYSAD 2650
L + ++L + K + ++++ +L L+ + +T + + L LL +
Sbjct: 4390 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4449
Query: 2651 DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANV 2710
K + W + ++ ER++ LEE L +F L++F+ WLT AE + N+
Sbjct: 4450 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 4509
Query: 2711 LQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVL 2770
A+ +L V +++ + E+ AH D LD+ + L+ L D VL
Sbjct: 4510 ---ASPPSLILNT---VLSQIEEHKVFANEVNAHRDQIIELDQTGNQ-LKFLSQKQDVVL 4562
Query: 2771 LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPI 2830
++ L ++ +W ++ ++S+ L+ + + K+ H + ++L+ WL+ + L + I
Sbjct: 4563 IKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEI 4622
Query: 2831 GGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPE 2890
D ++ Q H+ F++ L K+PV +T+ T R + + L PE
Sbjct: 4623 SNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRAL--------------KEKTLLPE 4668
Query: 2891 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 2950
+ +Q + L EV +W+ + S + Q K++E L + +A L L + E
Sbjct: 4669 D-SQKLDNFL----GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVE 4723
Query: 2951 VIKGSWQPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYN 3009
QPV GDL D + + ++ K + E+ V + R+L + +
Sbjct: 4724 PQLAEDQPVHGDL--DLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV 4781
Query: 3010 LSTLEDLNTRWKL---LQVAVEDRVRQ 3033
L++L+TRW L V+ + R+ Q
Sbjct: 4782 KGQLQELSTRWDTVCKLSVSKQSRLEQ 4808
Score = 296 bits (757), Expect = 3e-79
Identities = 510/2885 (17%), Positives = 1162/2885 (40%), Gaps = 305/2885 (10%)
Query: 339 RYQTALEEVLSWLLSAEDTLQA--QGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 396
++Q + + + +W+ + E ++ +++D V+++Q T + +L HQ V +
Sbjct: 1936 QFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQ 1995
Query: 397 QLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN--QKLK 454
++ ++ + VQE + + S ++ L + E+ S L + + Q+ + L+
Sbjct: 1996 KVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLE 2055
Query: 455 ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVD 514
L + + E+ + L + ++ + + L++D+ +++ + + MV
Sbjct: 2056 SLLQSIGEVEQNLEGKQVSSLSSGV--IQEALATNMKLKQDIARQKSSLEATREMVTRFM 2113
Query: 515 ESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEK 574
E++ A L+ +L + R+ +C +++ L+ +L + + S L +
Sbjct: 2114 ETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH----LSGKLQQF 2169
Query: 575 EDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQ 634
+ +++ +G + ++ Q++ L ++E +++++ L L +L S + Q
Sbjct: 2170 MENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQ 2229
Query: 635 KTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQP--SLTQTTVMETVTTVTTREQILV 692
+ VQ L K ++ + V + S Q + E V T ++ L
Sbjct: 2230 HQDR------------VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWL- 2276
Query: 693 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 752
K + +PP + E+ K+++ + L W ++ V + I K +
Sbjct: 2277 KETEGSIPPTETSMSAK-----ELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSL 2326
Query: 753 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE------QLNS 806
+L ++ A + Q + S V V + K +E +N
Sbjct: 2327 ENLIMEITAPDS---------QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNL 2377
Query: 807 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQP---------TTPS 857
++ + +L ER Q ++ A N+++++ + + WL+ + ++P+
Sbjct: 2378 KYEKLGGVLHER------QESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPT 2431
Query: 858 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIAL------KEKGQGPMFLDADFVAFT 911
+ +K+Q + K + L P+I+++K L ++ + + +
Sbjct: 2432 KTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEEL---N 2488
Query: 912 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 971
+ +++ AR+++L+ L +Q S +R W+ + E + + D ++
Sbjct: 2489 SRWERATEVTVARQRQLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSIDPNML 2546
Query: 972 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS---RKYQSEFEEIEGRWKKL 1028
+ ++Q + + ++ L+ + + P ++S + Q E + I +W +L
Sbjct: 2547 NAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQKWVEL 2605
Query: 1029 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1088
+ +L ++++ + K + Q +Q L + + V L + E +K+QL++
Sbjct: 2606 TDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETS 2665
Query: 1089 LLVSDIQTIQPSLN---------SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1139
+ SD++ + + SV G Q +K+E + RLET L D
Sbjct: 2666 EIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELK----KRLETVALPLQGLEDLAAD 2721
Query: 1140 QVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRA 1199
++ L+ L T Q+ E+ W+ + + + + LQ ++E +
Sbjct: 2722 RI----NRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEF 2777
Query: 1200 KEEAQQKEAKVKLLTESVNSVIAQAPPVAQE-ALKKELETLTTNYQWLCTRLNGKCKTLE 1258
++ Q +++ S++ PP ++ L+ +L L +++ L + + L+
Sbjct: 2778 QKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLK 2837
Query: 1259 EVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQ 1318
+ + ++E W+ + + K+ + S +L S + ++ E +
Sbjct: 2838 DCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRS-KAMLNEVEKRRSL 2896
Query: 1319 IRIL---AQTLTDGGVMDEL-INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS 1374
+ IL A L + DE I +E N + EE + LE+ Q +E ++S
Sbjct: 2897 LEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 2956
Query: 1375 LHLIQESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK-- 1430
I++ + QL + + + + + ++ + Q L + E ++ ++ QG
Sbjct: 2957 FKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVE 3016
Query: 1431 -----EAAQRVLSQIDVAQKKLQDVSMKFRL--------FQKPANFEQRLQESKMILDEV 1477
A ++L Q +VAQ++ +V + + F R++E L ++
Sbjct: 3017 DAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADL 3076
Query: 1478 KMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1537
L + + + +QSQ+ + +K ++E R +++++ T + L
Sbjct: 3077 DDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGL 3136
Query: 1538 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1597
+ AL +L + R++QLE L +++ L + A + + V
Sbjct: 3137 KRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVG 3196
Query: 1598 GMPSNLDSEVAWGKATQKE-IEKQKVHLKSITEVGEALKTVLGKKETL--VEDKLSLLNS 1654
++ ++A K QKE ++ ++ L+ + +G+ L GK + +E + +N+
Sbjct: 3197 TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINA 3256
Query: 1655 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLK 1714
W + + + + L E H F ++ + W+ + L+ + +K P + V+K
Sbjct: 3257 RWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI--ANQKPPSAEYKVVK 3314
Query: 1715 R-------LKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI 1767
L+ L+D + VD + + + + R+ + Q+ L R+ +
Sbjct: 3315 AQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL---- 3370
Query: 1768 KTGKASIPLKELEQ-----------------FNSDIQKLL---EPL---EAEIQQGVNLK 1804
KA+ K+LE F S +K L EP+ A+IQQ + ++
Sbjct: 3371 -LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQI-IR 3428
Query: 1805 EEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQR 1864
+ +D+ E++ V + ++ G +L +T ++ + K LQ +++ ++D ++
Sbjct: 3429 HKALEEDI-ENHATDVHQAVKIGQSLSS-LTSPAEQGVLSEKIDSLQARYSEIQDRCCRK 3486
Query: 1865 RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK----- 1919
+ + ++L L ++E KL+S+ +K+ +++ ++
Sbjct: 3487 AALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSV-------FVKDFKQDVLHRQHADHL 3539
Query: 1920 ---EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1976
EE+ ++ + ++G A+ + T ++ +++ + +A I +
Sbjct: 3540 ALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI-----KTRYADITVTSSK 3594
Query: 1977 TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKN 2036
+ + + L + STY ++ L EVE+ L + E + + ++ K
Sbjct: 3595 ALRTLEQARQLATKF-QSTY----EELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKE 3649
Query: 2037 IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 2096
+K + + +D ++ A L+ R L + +S + Q++ V+ R D
Sbjct: 3650 LKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEID 3709
Query: 2097 RSVEKWRRFHYDIKIFNQWLTEAEQFLRKT---QIPENWEHAKYKWYLKELQDGIGQRQT 2153
++++ +++ W+ E ++ L ++ ++ A+ + K I + +
Sbjct: 3710 AAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQ-VQKAFSIDIIRHKD 3768
Query: 2154 VVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQ 2213
+ L + EI + ++LQEK SL +++ + S+R RLE + ++++F
Sbjct: 3769 SMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW 3828
Query: 2214 RDLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGP 2272
E W+EE IA +P +QL+++ E+++ L E + + + +L + G
Sbjct: 3829 ETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ 3888
Query: 2273 VLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQ---GEIEAQIKDLGQLEKKLEDL 2329
+ ++PEE + +E K ++ + ++ + ++ E +Q + + K+E +
Sbjct: 3889 L---KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 3945
Query: 2330 EEQLNHLL--LWLSPIR----NQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2383
E L +L L + P+ +++ N+ ++++ + + +A + EE++ + Q
Sbjct: 3946 LETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4005
Query: 2384 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAK-----------QPDLAPGLTTIG- 2431
K+ A + ++ KL+ + W+ + +E K D+A LTTI
Sbjct: 4006 GADKDLAAKE-IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4064
Query: 2432 --------ASPTQTVTLVTQPVVTKETA---------------------------ISKLE 2456
SP +++ Q V ET K E
Sbjct: 4065 TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPE 4124
Query: 2457 MPSSLMLEVPALADFNRAWTE---------------------LTDWLSLLDQVIKSQRVM 2495
+ S+ A + N+ W E + DWL + + +
Sbjct: 4125 VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPV 4184
Query: 2496 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2555
DL + + + + K ++ Q++ ++E+L + + K +++ R II + + +++
Sbjct: 4185 GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKH 4244
Query: 2556 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2615
W+ + E + +R+ +L L Q+ A EE L L++ + I+ +
Sbjct: 4245 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4304
Query: 2616 ITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSE 2675
+ + L D+ Q V+ N +LL + DD + E +N W S+ ++ E
Sbjct: 4305 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4364
Query: 2676 REAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQ 2735
RE L+ T + Q F ++E FL LT E+ + A++ L ++ +E +
Sbjct: 4365 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS----ASKPTGGLPET--AREQLDTHM 4418
Query: 2736 DLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSH 2795
+L +++A + Y+ L + + +L S + S ++ + + KW + K +S
Sbjct: 4419 ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSK 4478
Query: 2796 LEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKE 2855
LE + + SLQE + WL L + L+ +P V Q + H+ F E+
Sbjct: 4479 LEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHR 4538
Query: 2856 PVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLN 2915
I+ +L Q +L + Q+V L++ V + WEK+
Sbjct: 4539 DQII-------------------ELDQTGNQLKFLSQKQDVV-LIKNLLVSVQSRWEKVV 4578
Query: 2916 LHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG---DLLIDSLQDHLE 2972
S + R +D+ +R ++ EA +L L AE S + D + L H E
Sbjct: 4579 QRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKE 4638
Query: 2973 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVR 3032
K L G+ P+ + ++ T L + + L ++ +W + +R
Sbjct: 4639 FQKTLGGK-QPVYDTTIRTGRALKEKTLLPEDSQKLD-NFLGEVRDKWDTVCGKSVERQH 4696
Query: 3033 QLHEA 3037
+L EA
Sbjct: 4697 KLEEA 4701
Score = 245 bits (625), Expect = 7e-64
Identities = 537/2938 (18%), Positives = 1125/2938 (38%), Gaps = 422/2938 (14%)
Query: 344 LEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMM--DLTAHQGRVGNILQLGSK 401
++E+L W+ + Q + S E + E ++ +LT + +V ++
Sbjct: 1431 VKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQI 1490
Query: 402 LIGTG--KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNL---------HRVLMDLQN 450
+ KLSE E+ ++ EQ+N LN + L S + L + L QN
Sbjct: 1491 FLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQN 1550
Query: 451 ---QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLT 507
Q+L++L W+ + E + DL L++ K LQ+D++ N T
Sbjct: 1551 TCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQ------NRAT 1604
Query: 508 HMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLF 567
VV + G +EE L R R L +++ L EE +
Sbjct: 1605 SFATVVKDIEG-----FMEENQTKLSPRELTALR------EKLHQAKEQYEALQEETRVA 1653
Query: 568 SAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL---KQDLL 624
L E + + T K E+ + +K+ L + S G+L + + L
Sbjct: 1654 QKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLS 1713
Query: 625 STLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVT-- 682
K T+ ++ + + L ++ E A+ + ++ Q + T +
Sbjct: 1714 GASLEKGALDTTDGYM-GVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQ 1772
Query: 683 ---TVTTREQILVKHAQEE--------LPPPPPQKKRQITVDSEIRKRLDVDITELHSWI 731
+T EQ +++ E L + K+ T+ E++K L D E SW+
Sbjct: 1773 HGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQ-DHKEFESWL 1831
Query: 732 TRSEAVLQ-------SPEF--AIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 782
RSE L+ SPE ++ +++G+FS+ R +K+ D S +
Sbjct: 1832 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 1891
Query: 783 LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMT 842
E + D +K A+E+ + + C L LN L Q + F N L+
Sbjct: 1892 GKEPSEIGNLVKDKLKDATERYTALHSK-CTRLGSHLNMLLGQYH--QFQNSADSLQAWM 1948
Query: 843 TTAENWLK--IQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERL-KIQSIALKEKGQ- 898
E ++ + T S+P ++ QL K L+ Q +E+L K+ ++ +G+
Sbjct: 1949 QACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEP 2008
Query: 899 --GPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET 956
+ + +HF+ + + R LQ QE++ ++ + + E
Sbjct: 2009 APDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAI--AQSQSVQESLESLLQSIGEVEQ 2066
Query: 957 KLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQS 1016
L Q+S ++++ L L+ + Q+S L V + A S + Q
Sbjct: 2067 NLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQG 2126
Query: 1017 EFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGD 1076
+ E+ R+++L C + +E+ + L+K+ + + ++ F++ + L
Sbjct: 2127 KLAEVSQRFEQL-------CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLAS 2179
Query: 1077 ----SEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNT 1132
+ + +Q + L +++ Q +L+++ ++ + + + ++ L
Sbjct: 2180 GNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRK 2239
Query: 1133 QWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKA 1192
+ + + V R++ E+ +K + +W+ + E + + EL+K
Sbjct: 2240 DFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS-MSAKELEKQ 2298
Query: 1193 VEEMKRAKEEAQQKEAKVKLL----TESVNSVIAQAPPVAQ------------------- 1229
+E +K ++ K V+ + T N ++ P +Q
Sbjct: 2299 IEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNG 2358
Query: 1230 -------EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE 1282
++ ++ + Y+ L L+ + ++L+ + E+ +WL E
Sbjct: 2359 YHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKE 2418
Query: 1283 FKLKTTE--NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEE- 1339
LK+ + + P E + +S + + E N +I+ + + L G++ N +
Sbjct: 2419 EVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEAL--AGLLVTYPNSQE 2476
Query: 1340 -------LETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAY 1392
E NSRW E V RQ+ LE+S + + ++ L + +
Sbjct: 2477 AENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVL 2536
Query: 1393 IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLS-------QIDVAQK 1445
+D + + Q++Q L E ++H Q EAAQ +L+ QK
Sbjct: 2537 GPLSIDPNMLNAQKQQVQFMLKEFE---ARRQQHEQLNEAAQGILTGPGDVSLSTSQVQK 2593
Query: 1446 KLQDVSMKF---------------RLFQKPANFEQRLQESKMILDEVKMHLPALETKSVE 1490
+LQ ++ K+ + K +++ LQ+ + V L S +
Sbjct: 2594 ELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQ 2653
Query: 1491 QEVVQSQLNHCVNLYKSLSEVKSEV--------EMVIKTGRQIVQKKQTENPKELDERVT 1542
E V+ QL + L ++ EV E+ + G Q ++ EL +R+
Sbjct: 2654 PEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK-------DELKKRLE 2706
Query: 1543 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1602
+ L L +R +L+ L +++ ++ + L WL + K +
Sbjct: 2707 TVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLER 2766
Query: 1603 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL--GKKETLVEDKLSLLNSNWIAVT 1660
L S++ + QK + + + I GE+L + G+++ ++++L L ++W ++
Sbjct: 2767 LQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELS 2826
Query: 1661 SRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE-KKKPQQKEDVLKRLKAE 1719
+ + + L + + + + +V+ + WI + E P Q E L R KA
Sbjct: 2827 KKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAM 2886
Query: 1720 LNDI--RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIP-- 1775
LN++ R + + AA+++ N + + + + +N A++ ++ S+
Sbjct: 2887 LNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEM 2946
Query: 1776 ---LKELEQFNSDIQKLLEPLEAEIQ----------QGVNLKE----------------- 1805
L+E ++ +I+K +E + +++ NL++
Sbjct: 2947 TQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDY 3006
Query: 1806 -EDFNKDMNED--NEGTVKELLQRGDNLQQRITDERKREE-----IKIKQQLLQTKHNAL 1857
+F + + ED + +LL + + QQ + ++R ++ K + + H +
Sbjct: 3007 LRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRV 3066
Query: 1858 KDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEID----- 1912
+++ SQ E+ R D L ++D+ L + + + + E +
Sbjct: 3067 REMFSQLADLDDELDGMG-AIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHML 3125
Query: 1913 -----RELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNF 1967
+L K EL A+ +Q L+E G A Q QL +E + + + LN
Sbjct: 3126 EEEGTLDLLGLKRELEALNKQCGKLTERGKA-----RQEQLELTLGRVEDFYRKLKGLND 3180
Query: 1968 AQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDL 2027
A E + + TE+ ++Q L + +
Sbjct: 3181 ATTAAEEAEALQWVVG--------------TEVEIINQQLADFKMF-------------- 3212
Query: 2028 FKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVK-LQEALSQLDFQWEKVNK 2086
Q+E + ++ LQQ +G +QSA V+ L+ + +++ +W +NK
Sbjct: 3213 --QKEQVDPLQMKLQQVNG-------LGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNK 3263
Query: 2087 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKE--- 2143
R + ++ +F ++ WL + E+ + Q P + E+ K ++E
Sbjct: 3264 KVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI-ANQKPPSAEYKVVKAQIQEQKL 3322
Query: 2144 LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLE 2203
LQ + R+ V L A G I Q + D + +L SL RW E+ + + R+K+LE
Sbjct: 3323 LQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3382
Query: 2204 EQKNILSEFQ---RDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQ 2260
+ + +F +++F+ E+ +A+ + ++++++ + K L E++
Sbjct: 3383 DILVLAKQFHETAEPISDFLSVTEK--KLANSEPVGTQTAKIQQQIIRHKALEEDIENHA 3440
Query: 2261 GILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLG 2320
+ Q + G +S+ SP EQ L K+ ++ ++ K ++ + +
Sbjct: 3441 TDVHQAVKIGQS--LSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNAR 3498
Query: 2321 QLEKKLEDLEEQLNHLLLWLSPIRNQL-EIYNQPNQEGPFDVQETE-----IAVQAKQPD 2374
ED E LN WL+ + ++L ++ + ++ Q + + ++ +
Sbjct: 3499 LFG---EDEVEVLN----WLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKN 3551
Query: 2375 VEEILSKGQHLYKEKPATQP--VKRKLEDLSSEW--------KAVNRLLQE--------- 2415
V++ + GQ L K+ + ++ KL+ + + + KA+ L Q
Sbjct: 3552 VDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQS 3611
Query: 2416 --------LRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA 2467
LR + +LA T+ G SPT Q ++ + K M L+L+
Sbjct: 3612 TYEELTGWLREVEEELA---TSGGQSPTGEQIPQFQ---QRQKELKKEVMEHRLVLD--T 3663
Query: 2468 LADFNRAWTELTDWLSL--LDQVI---KSQRVMVGD-----LEDINEMIIK--------- 2508
+ + +RA EL W + LD+++ Q +V D +++I+ I +
Sbjct: 3664 VNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAAD 3723
Query: 2509 --------------------------------QKATMQDLEQRRPQLEELITAAQNLKNK 2536
QKA D+ + + ++EL + +
Sbjct: 3724 AELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFG- 3782
Query: 2537 TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQAR 2596
T +E +T++ ++ E + Q++ + R +L Q+ E EE + + R
Sbjct: 3783 TCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETR 3842
Query: 2597 AKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLA--LKLLRDYSADDTRK 2654
A + + ++++ E +QL + + + + ++D + LK L + +
Sbjct: 3843 ALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE 3902
Query: 2655 VHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDA 2714
+ EN+ A I + V +R AL+E Q +K L ET N+
Sbjct: 3903 KYQKAENMYA---QIKEEVRQRALALDEAVSQSTQITEFHDKIEPML---ETLENLSSRL 3956
Query: 2715 TRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD---AVLL 2771
+ + ++E + + E+E + L ++++ +G+D A +
Sbjct: 3957 RMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEI 4016
Query: 2772 QRRLDNMNFKWSELR----KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2827
Q +LD M F W +++ ++ + LE + W + LL ++ D +
Sbjct: 4017 QDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFW----YDMAALLTTIKDTQDIVHDL 4072
Query: 2828 APIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPREL 2887
G D +++Q + K E + LE +RI G + ++
Sbjct: 4073 ESPGIDPSIIKQQVEAAETIKEETDG----LHEELEFIRIL-------GADLIFACGETE 4121
Query: 2888 PPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLR 2947
PE +RK +E+N WE LN W+ ++++ + +Q + D L
Sbjct: 4122 KPE---------VRKSIDEMNNAWENLN---KTWKERLEKLEDAMQAAVQYQDTLQAMFD 4169
Query: 2948 QAE--VIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLK---ENVSHVNDLARQLTT 3000
+ VIK P +++++D L ++K + E+ + E ++H +L + T
Sbjct: 4170 WLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKAT 4227
Score = 241 bits (614), Expect = 1e-62
Identities = 572/2968 (19%), Positives = 1186/2968 (39%), Gaps = 464/2968 (15%)
Query: 293 KSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLL 352
K+ T+A + +++ R P L A S E E NL + E+LSW+
Sbjct: 549 KAEPLTKATHSSSTSWFRKPMTRAELVA-------ISSSEDEGNL----RFVYELLSWVE 597
Query: 353 SAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKL----IGTGKL 408
+ L+ + E ND+ V+ Q T + ++ +LGS + + GK+
Sbjct: 598 EMQMKLE-RAEWGNDLPSVELQLETQQHIHT----------SVEELGSSVKEARLYEGKM 646
Query: 409 SEDEETEVQEQMNLLNSRWECLRVAS---MEKQSNLHRVLMDLQNQKLKELNDWLTKTEE 465
S++ T E + L +++ L+ S M +LH+ + + + WL + EE
Sbjct: 647 SQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELI-----WLNEKEE 701
Query: 466 RTRKMEEEPLGPDLEDLKRQVQQHK----VLQEDLEQEQVRVNSLTHMVVVVD------E 515
E L D D + + L +LE++Q SL ++ +
Sbjct: 702 -------EELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAK 754
Query: 516 SSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKE 575
+ + +AA++ QL+ + +C E +++ +Q ++ + L S +L +
Sbjct: 755 QTVEAYSAAVQSQLQWM----KQLCLCVEQH---VKENTAYFQFFSDARELES-FLRNLQ 806
Query: 576 DAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL-KNKSVTQ 634
D++ + ++ D N LS L+ L L+ +++K+Q L K + S + ++K++ Q
Sbjct: 807 DSIKRKYSC---DHNTSLSRLEDL--LQDSMDEKEQ----LIQSKSSVASLVGRSKTIVQ 857
Query: 635 KTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETV---TTVTTREQIL 691
D+ K+T + Q +T E V + T+ +++
Sbjct: 858 LKPRSPDHVL-----------KNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVI 906
Query: 692 VKHAQEELPPP-----PPQKKRQITVDSEIRK----------RLDVDITELHSW--ITRS 734
E + P PP K I + S + + +L V+ L SW + +
Sbjct: 907 SPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKD 966
Query: 735 EAVLQSPEFAIFRK-------------EGNFSD-LKEKVNAIEREKAEKFRKLQDASRSA 780
++Q+ R + ++ D L++ +++ A++ R L++ +
Sbjct: 967 LDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLR-LEEEVEAC 1025
Query: 781 QALVEQMVNEGVNAD--------------SIKQASEQLNSRWIEFCQ-LLSERLNWLEYQ 825
+A + ++ N D +I+ E+ R ++ Q L S R + +Q
Sbjct: 1026 KARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ 1085
Query: 826 NNIIAFYNQ------LQQL----EQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNR 875
+N + Q LQQL + ++ +++L P++ S PT ++S+L + ++++
Sbjct: 1086 DNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPT-LRSELNLLVEKMDH 1144
Query: 876 LSGLQP-QIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDT 934
+ GL + +LK + ++ + + + + + V +D+ A E T+
Sbjct: 1145 VYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQE-EVVLADLSALEAHWSTL--- 1200
Query: 935 LPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYY 994
R W+ + K S+ SV D EI + ++
Sbjct: 1201 -------------RHWLSDVKDKNSV--FSVLDEEIAKAKV------------------- 1226
Query: 995 LSTTVKEMSKKAPSEIS--RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNH 1052
++MS+ P +YQ + +++ RW ++ +QL +LE L +
Sbjct: 1227 ---VAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRAC 1283
Query: 1053 IQTLKKWMAEVDVFLKEEWPALG-DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 1111
TL KW+ E + P DS +L +QL Q L ++I+ Q L+ + Q+
Sbjct: 1284 HGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQY 1343
Query: 1112 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1171
+ ++ +L T + +Q Q+ ++ + + DL + +
Sbjct: 1344 STIVK-DYELQLMTYKAFVESQ-----QKSPGKRRRMLSSSDAITQEFMDLRTRYTALVT 1397
Query: 1172 AEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEA 1231
++++ D L++ EE K +EE Q+ KVK L V+++ A +
Sbjct: 1398 LTTQHVK-----YISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSS 1452
Query: 1232 LKKE---LETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTT 1288
KE +E Q L L K + + E ++ + +L + KL
Sbjct: 1453 ETKESTDIEKAILEQQVLSEELTTKKEQVSEA----------IKTSQIFLAKHGHKLSEK 1502
Query: 1289 ENIPGGAEEISEVLDSLENLMRH-SEDNPNQIRILAQTL---TDGGVMDELIN---EELE 1341
E ++ISE L++L + + NQ++ L L T+ + + N ++LE
Sbjct: 1503 EK-----KQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLE 1557
Query: 1342 TFNSRWRELHEEAV--RRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDA 1399
S W E A+ + + +Q + + Q+ + L +Q+ + A + D
Sbjct: 1558 DLCS-WVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKD---- 1612
Query: 1400 AQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQD-VSMKFRLFQ 1458
+ ++ Q+ L+ E++ K H Q KE + + + VAQK+L++ V+ +
Sbjct: 1613 --IEGFMEENQTKLSPRELTALREKLH-QAKEQYEALQEETRVAQKELEEAVTSALQQET 1669
Query: 1459 KPANFEQRLQESKMILD--------------EVKMHLPALET---KSVEQEVVQSQLNHC 1501
+ + + L E+K +D ++ +LP +E S+E+ + + +
Sbjct: 1670 EKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGY- 1728
Query: 1502 VNLYKSLSEVKSEVEMVIKTGRQIVQKKQT---------------------ENPKELDER 1540
+ + ++ ++ + EM+ ++++ ++Q E + L ++
Sbjct: 1729 MGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQK 1788
Query: 1541 VTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMP 1600
+ LK Y+ A+ +Q++ +K ++ WL ++ EL P
Sbjct: 1789 LGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSP 1848
Query: 1601 SNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTV-----LGKKET----LVEDKLSL 1651
L S + + +++ K L+ +T G+ + + GK+ + LV+DKL
Sbjct: 1849 ETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKD 1908
Query: 1652 LNSNWIAVTS---RAEEWLNLLLEYQKHMETFDQNVDHITKWI----IQADTLLDESEKK 1704
+ A+ S R LN+LL Q H F + D + W+ + LL ++
Sbjct: 1909 ATERYTALHSKCTRLGSHLNMLLG-QYHQ--FQNSADSLQAWMQACEANVEKLLSDTVAS 1965
Query: 1705 KP---QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----DHCRKLVEPQISELN 1757
P Q++ K+L+ EL + + V+ + A ++M G DH R + E S L+
Sbjct: 1966 DPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDH-RHVQETTDSILS 2024
Query: 1758 HRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNE 1817
H F ++S+ + ++S+ K + Q Q + E LE+ +Q +++ K ++ +
Sbjct: 2025 H-FQSLSYSL-AERSSLLQKAIAQ----SQSVQESLESLLQSIGEVEQNLEGKQVSSLSS 2078
Query: 1818 GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1877
G ++E L L+Q I ++ E ++ + + A + + K E+S ++ Q
Sbjct: 2079 GVIQEALATNMKLKQDIARQKSSLE-ATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQ 2137
Query: 1878 ---------------------YKRQADDLLKCLDDIEKKLASLPEPRDE-----RKIKEI 1911
++ + L + +++ + LAS +P + ++I+E+
Sbjct: 2138 LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQEL 2197
Query: 1912 DRELQKKKEELNAVRRQAEGLSEDGAAMAV------------EPTQIQLSKRWREIESKF 1959
+ E++ ++E L+ + LS G A+ + + T++Q + + RE ++
Sbjct: 2198 NLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASS 2257
Query: 1960 AQ-----FRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLL 2014
Q FR+L + T ++ P E S +I H+ L
Sbjct: 2258 CQEQLDEFRKL----VRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLL------- 2306
Query: 2015 NAPDLCAKD--FEDLFKQEESLKNI------KDSLQQSSGRIDIIHSKKTAALQSATPVE 2066
D +K E++ + SL+N+ DS ++ + + S + T +
Sbjct: 2307 --DDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKD 2364
Query: 2067 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT 2126
++Q +S ++ ++EK+ + +RQ + + H + QWL E+ L+
Sbjct: 2365 LTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSM 2424
Query: 2127 QI---PENWEHAK-----YKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQ 2178
P E K K +L EL+ + Q V L ++ + +A +
Sbjct: 2425 DAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL---LVTYPNSQEAENWK 2481
Query: 2179 EKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASI--PLEP 2236
+ LN RW+ + R+++LEE + L+ FQ ++ WL E + + + PL
Sbjct: 2482 KIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI 2541
Query: 2237 GKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNL 2296
L + +QV+ +++E R+ +QLNE +L +++ +L+ N
Sbjct: 2542 -DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQ 2600
Query: 2297 QWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQE 2356
+W++++ L + +I+ I Q ++ L+DL E++ + LS Q I QP
Sbjct: 2601 KWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSV---QSAISTQPE-- 2655
Query: 2357 GPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL 2416
AV+ + + EI S + L E Q + +L L E + L + L
Sbjct: 2656 ----------AVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRL 2705
Query: 2417 RAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 2476
+TV L Q + ++ A ++ + L + + F + +
Sbjct: 2706 -------------------ETVALPLQGL--EDLAADRI---NRLQAALASTQQFQQMFD 2741
Query: 2477 ELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNK 2536
EL WL + LE + + + + + L Q E ++ ++L
Sbjct: 2742 ELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLS 2801
Query: 2537 TSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQAR 2596
E + + +++ ++N W+E+ + +R+ +L + ++ + ++ E+ + +
Sbjct: 2802 VPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCK 2861
Query: 2597 AKLESWKEGPYTVDAIQ--KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRK 2654
AK+ + T+D +Q + +K + ++ + ++ +++ N A L+ AD+
Sbjct: 2862 AKMSELR---VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADED-G 2917
Query: 2655 VHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDA 2714
+ IN + ++ + + + +LEE + L++F E F + E + L+
Sbjct: 2918 IRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQ---ESFKNIEKKVEGAKHQLEIF 2974
Query: 2715 TRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR 2774
+K +++L Q + LQ +E D N +Q ++ DA L +
Sbjct: 2975 DALGSQACSNKNLEKLRAQQEVLQA-LEPQVDYLRNF---TQGLVEDAPDGSDASQLLHQ 3030
Query: 2775 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDF 2834
+ ++ E++++ + +E + + H ++E+ L DDEL IG D
Sbjct: 3031 AEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDT 3090
Query: 2835 PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGL--EKLYQEPRELPPEER 2892
++Q Q +E VR+FL + + L E E R + EE
Sbjct: 3091 DSLQSQ---------------------IEDVRLFLNKIHVLKLDIEASEAECRHMLEEEG 3129
Query: 2893 AQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVI 2952
++ L+++ E +N + KL Q +++ TL R+++ L+ AE
Sbjct: 3130 TLDLLG-LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEA 3188
Query: 2953 KGSWQPVGDLLIDSLQDHLEKVKALRGE-IAPLKENVSHVNDLARQL-TTLGIQLSPYNL 3010
+ VG ++ + L K + E + PL+ + VN L + L + G L
Sbjct: 3189 EALQWVVG-TEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGL 3247
Query: 3011 S-TLEDLNTRWKLLQVAVEDRVRQLHEA 3037
+E++N RW L V R+ QL EA
Sbjct: 3248 EHDMEEINARWNTLNKKVAQRIAQLQEA 3275
Score = 211 bits (537), Expect = 1e-53
Identities = 114/232 (49%), Positives = 151/232 (65%), Gaps = 5/232 (2%)
Query: 6 SDEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGST 65
+DER+ VQKKTFTKWVN K K HI +L+ DL+DG L+ LLE L+G KLP+EKG
Sbjct: 73 ADERDRVQKKTFTKWVNKHLMKVRK-HINDLYEDLRDGHNLISLLEVLSGIKLPREKGRM 131
Query: 66 RVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMA 125
R H L NV AL L+ V LVNI + DI DGN KLTLGLIW IILH+Q+ ++ + +
Sbjct: 132 RFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGES 191
Query: 126 GLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQ 185
G + EK+LL W ++ T Y + NF++ WSDG NALIH +RPDL D V
Sbjct: 192 G-DMSAKEKLLL-WTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQI- 248
Query: 186 QSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 237
QS + LE AF +A +LG+ +LLD EDVD PD+KS++ Y++S++ P+
Sbjct: 249 QSNRENLEQAFEVAE-RLGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPK 299
Score = 196 bits (498), Expect = 4e-49
Identities = 481/2824 (17%), Positives = 1126/2824 (39%), Gaps = 356/2824 (12%)
Query: 417 QEQMNLLNSRWECLRVASME-KQSNLHRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEE 473
QE+ + L RW + +A +E +QS L + L + + L W+ +T + ++M +
Sbjct: 1246 QEKGSQLQERWHRV-IAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQ-QEMMKP 1303
Query: 474 PLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN-----SLTHMVVVVD-------------- 514
D L Q+ Q L ++E+ Q +++ S + +V D
Sbjct: 1304 GQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVES 1363
Query: 515 --ESSGDH-----ATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLF 567
+S G ++ A+ ++ L R+ + T + D L +RL EE+ +
Sbjct: 1364 QQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDAL---RRLEEEEKVV 1420
Query: 568 SAWLSEKEDAVNKI------------HTTG------FKDQNEMLSSLQKLAVLKADLEKK 609
EK++ V K+ +T G K+ ++ ++ + VL +L K
Sbjct: 1421 E---EEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTK 1477
Query: 610 KQSMGKLYSLKQDLL-------STLKNKSVTQKTEAWLDNFARCWD---NLVQKLEKSTA 659
K+ + + Q L S + K ++++ A + D N +Q+L+ A
Sbjct: 1478 KEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLA 1537
Query: 660 -QISQAVTTTQPSLTQTTVMETVTTVTTREQILVKH----AQEELPPPPPQKKRQITVDS 714
Q Q Q + + + + V E+ L H Q++L + +
Sbjct: 1538 HQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQD 1597
Query: 715 EIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQ 774
+I+ R T + + E ++ + + +E + L+EK++ + E++ LQ
Sbjct: 1598 DIQNRA----TSFATVVKDIEGFMEENQTKLSPRE--LTALREKLH----QAKEQYEALQ 1647
Query: 775 DASRSAQALVEQMVNEGVNADSIK-QASEQLNSRWIEFCQLLSERLNWLEYQNNIIA-FY 832
+ +R AQ +E+ V + ++ K +A+++L E + + L+W+ +
Sbjct: 1648 EETRVAQKELEEAVTSALQQETEKSKAAKEL----AENKKKIDALLDWVTSVGSSGGQLL 1703
Query: 833 NQLQQLEQMTTTAENWLKIQPT-----TPSEPTAIKSQLKICKDEVNRLSGLQPQ-IERL 886
L +EQ++ + + T P + Q ++ K L Q I
Sbjct: 1704 TNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILAT 1763
Query: 887 KIQSIALKEKGQG-----PMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQ 941
+ L + G L + + +A K++QT+ D L ++
Sbjct: 1764 QSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDEL--QKFL 1821
Query: 942 ETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKE 1001
+ +W+++SE +L + E + L + + + L +++ + ++
Sbjct: 1822 QDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQK 1881
Query: 1002 M--------SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHI 1053
+ K PSEI + + ++ R+ L S+ L + + + QN
Sbjct: 1882 VLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSA 1941
Query: 1054 QTLKKWM----AEVDVFLKEEWPALGDSEILKKQL---KQCRLLVSDIQTIQPSLNSVNE 1106
+L+ WM A V+ L + D +L++QL KQ + +++ Q L V
Sbjct: 1942 DSLQAWMQACEANVEKLLSDT--VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR 1999
Query: 1107 GGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMH 1166
+I+ E P+ ET + + + + + R L+ + ++ S+Q+ L +
Sbjct: 2000 DIMEIEGEPAPDHRHVQETT-DSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2058
Query: 1167 EWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPP 1226
+ + + E+ + + +Q+A+ + K++ ++++ ++ E V + A
Sbjct: 2059 QSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADS 2118
Query: 1227 VAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLK 1286
L+ +L ++ ++ LC + K +L+++ E+ +L + E + ++
Sbjct: 2119 TTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLP-QAEMFEHLSGKLQQFMENKSRML 2177
Query: 1287 TTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD----GGVMDELINEE-LE 1341
+ N P ++I+ ++ L ED + L +T+ G +D +++ ++
Sbjct: 2178 ASGNQPD--QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQ 2235
Query: 1342 TFNSRWRELHEEAVRRQK--------------LLEQSIQSAQETEKSLHLIQESLTF--I 1385
+ EL + R+K L+ + +ETE S+ + S++ +
Sbjct: 2236 NLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKEL 2295
Query: 1386 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHE-ISLEEMKKHNQGKEAA----------- 1433
+KQ+ + D A ++I TS E + +E +QGK +
Sbjct: 2296 EKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGS 2355
Query: 1434 ---QRVLSQIDVAQKKLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPALE 1485
+ Q + DV++K+ L ++ + + L + + E L LE
Sbjct: 2356 VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLE 2415
Query: 1486 TKS------------VEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIV----QKK 1529
+K + E V++Q L + +++ V + ++ +
Sbjct: 2416 SKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQ 2475
Query: 1530 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1589
+ EN K++ E + + E+ R++QLE+ + + L WL ++
Sbjct: 2476 EAENWKKIQEELNSRWERATEV---TVARQRQLEESASHLACFQAAESQLRPWLMEKELM 2532
Query: 1590 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGK---KETLVE 1646
+ + P+ L+++ + KE E ++ + + E + + T G + V+
Sbjct: 2533 MGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQ 2592
Query: 1647 DKLSLLNSNWIAVT-------SRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1699
+L +N W+ +T S+ ++ + +YQ+ ++ + V + + + +
Sbjct: 2593 KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAIST 2652
Query: 1700 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG-----DHCRKLVEPQIS 1754
+ E K Q +E ++++L + +V + L G D +K +E
Sbjct: 2653 QPEAVKQQLEET--SEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVAL 2710
Query: 1755 ELNHRFAAISHRIKTGKASIP-LKELEQFNSDIQKLLE----------PLEAEIQ--QGV 1801
L + RI +A++ ++ +Q +++ L+ P+ A+++ Q
Sbjct: 2711 PLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQ 2770
Query: 1802 NLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLR 1861
+ E+F K +N+ + G+ + ++ G++L + ++ ++ + L+ L
Sbjct: 2771 LQENEEFQKSLNQ-HSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKT 2829
Query: 1862 SQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEE 1921
+ R+ + + + +Y+ +DL+ ++D + K++ L D +++ L + K
Sbjct: 2830 ADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDP---VQLESSLLRSKAM 2886
Query: 1922 LNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVM 1981
LN V ++ L +A + + + I + A + A ++ +T +
Sbjct: 2887 LNEVEKRRSLLEILNSAADILINSSEADEDG--IRDEKAGINQNMDAVTEELQAKTGSL- 2943
Query: 1982 TEDMPLEISYVPSTYLTEITHVSQAL--LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKD 2039
E+M + ++ V A LE+ L + K+ E L Q+E L+ ++
Sbjct: 2944 -EEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3002
Query: 2040 SLQQSSGRIDIIHSKKTAALQSA---TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 2096
++D + + ++ A + ++ Q ++Q +F +V + +
Sbjct: 3003 -------QVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL--EVKQRVNSGCVMME 3053
Query: 2097 RSVEKWRRFHYDIK-IFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVV 2155
+E +FH ++ +F+Q ++ I + + + + +++++ + + +
Sbjct: 3054 NKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQ--IEDVRLFLNKIHVLK 3111
Query: 2156 RTLNATGEE---IIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNI---- 2208
+ A+ E ++++ D L+ +L +LN + C +L++R K +EQ +
Sbjct: 3112 LDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQ----CGKLTERGKARQEQLELTLGR 3167
Query: 2209 LSEFQRDL---NEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL--PLRQGI 2262
+ +F R L N+ EEA+ + + G E ++ ++L K+ +E PL+
Sbjct: 3168 VEDFYRKLKGLNDATTAAEEAEALQWVV---GTEVEIINQQLADFKMFQKEQVDPLQMK- 3223
Query: 2263 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 2322
L+Q+N G ++ SA + Q LE+ +++ N +W +++ + ++ +++ + G+
Sbjct: 3224 LQQVNGLGQGLIQSAGKDCDVQG-LEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKF 3282
Query: 2323 EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPF---DVQETEIA---VQAKQPDVE 2376
+ LE L L WL+ + P+ E +QE ++ + ++ V+
Sbjct: 3283 QDALEPL-------LSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVD 3335
Query: 2377 EILSKGQHLYK--EKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASP 2434
+ ++G + + E + + +LE L S W LL + A+Q L L
Sbjct: 3336 MLQAEGGRIAQSAELADREKITGQLESLESRW---TELLSKAAARQKQLEDIL------- 3385
Query: 2435 TQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 2494
V+ K+ F+ ++D+LS+ ++ + +
Sbjct: 3386 ----------VLAKQ---------------------FHETAEPISDFLSVTEKKLANSEP 3414
Query: 2495 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 2554
+ I + II+ KA +D+E + + + Q+L + TS E + +++++I+ +Q
Sbjct: 3415 VGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE-QGVLSEKIDSLQ 3473
Query: 2555 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 2614
++ E+Q+ + L++ L ++ + E + E L + KL S + D + +
Sbjct: 3474 ARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHR 3533
Query: 2615 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 2674
+ + L +++ + NVD A LL+ + ++ + + I + I S
Sbjct: 3534 QHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSS 3593
Query: 2675 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 2734
+ LE+ +L +F E+ WL E E ++ + + + ++
Sbjct: 3594 KALRTLEQARQLATKFQSTYEELTGWLREVE------EELATSGGQSPTGEQIPQFQQRQ 3647
Query: 2735 QDLQGEIEAHTDVYHNLDENSQKIL-----RSLEGSDDAVLLQRRLDNMNFKWSELRKKS 2789
++L+ E+ H V ++E S+ +L R+ EG D V + N ++ +
Sbjct: 3648 KELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLV------SDANEQYKLVSDTI 3701
Query: 2790 LNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKR 2849
++A+ + ++ + L W+ +L PI + Q V +AF
Sbjct: 3702 GQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAF-- 3759
Query: 2850 ELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNT 2909
+++ +R + +++L+ E+ + T +L+++ E +
Sbjct: 3760 -----------SIDIIR------HKDSMDELFSHRSEIFGTCGEEQKT-VLQEKTESLIQ 3801
Query: 2910 EWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQD 2969
++E ++L +++ +++ + + E +EL + + + P + + L+
Sbjct: 3802 QYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQ-LPSPAIDHEQLRQ 3860
Query: 2970 HLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVED 3029
E+++ LR IA K ++ + + QL +L+P +E+ + + + +++
Sbjct: 3861 QQEEMRQLRESIAEHKPHIDKLLKIGPQLK----ELNPEEGEMVEEKYQKAENMYAQIKE 3916
Query: 3030 RVRQ 3033
VRQ
Sbjct: 3917 EVRQ 3920
Score = 184 bits (467), Expect = 1e-45
Identities = 361/1991 (18%), Positives = 773/1991 (38%), Gaps = 283/1991 (14%)
Query: 328 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 387
+ L E+ ++ ++Q ALE +LSWL E+ + Q S + +VVK Q + L
Sbjct: 3270 AQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDD 3329
Query: 388 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECL--RVASMEKQSNLHRVL 445
+ V + G ++ + +L++ E+ + Q+ L SRW L + A+ +KQ VL
Sbjct: 3330 RKATVDMLQAEGGRIAQSAELADREK--ITGQLESLESRWTELLSKAAARQKQLEDILVL 3387
Query: 446 MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 505
++ + ++D+L+ TE++ EP+G +++Q+ +HK L+ED+E V+
Sbjct: 3388 AKQFHETAEPISDFLSVTEKKLAN--SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQ 3445
Query: 506 LTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQC 565
+ + + L E++ L R++ I + LL L + E++
Sbjct: 3446 AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEV 3505
Query: 566 LFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLS 625
WL+E ED ++ + FK LA L ++ +K+++ + Q LL
Sbjct: 3506 EVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLA-LNEEIVNRKKNVDQAIKNGQALLK 3564
Query: 626 TLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVT 685
+ V E D + + T S+A+ T + + T ++
Sbjct: 3565 QTTGEEVLLIQEKL--------DGIKTRYADITVTSSKALRTLEQARQLATKFQS----- 3611
Query: 686 TREQIL--VKHAQEELPPPPPQKK--RQITVDSEIRKRLDVDITELHSWI--TRSEAVLQ 739
T E++ ++ +EEL Q QI + +K L ++ E H + T +E
Sbjct: 3612 TYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVME-HRLVLDTVNEVSRA 3670
Query: 740 SPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQ 799
E +R L N E+++ + D + Q V+E D+ Q
Sbjct: 3671 LLELVPWRAREGLDKLVSDAN-------EQYKLVSDT-------IGQRVDE---IDAAIQ 3713
Query: 800 ASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEP 859
S+Q Q L W+ + ++ LEQ TTA+ L++Q
Sbjct: 3714 RSQQYE-------QAADAELAWVAETKRKLMALGPIR-LEQDQTTAQ--LQVQK------ 3757
Query: 860 TAIKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQV 917
A + KD ++ L + +I + Q L+EK + + + ++ N
Sbjct: 3758 -AFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTES-LIQQYEAISLLN----- 3810
Query: 918 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 977
S+ AR + Q + + ++ ET + W++++ ++ D+E + Q+ E
Sbjct: 3811 -SERYARLERAQVLVN-----QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEE 3864
Query: 978 LQALQSSLQEQQ---SGLYYLSTTVKEMSKKAPSEISRKYQSEF-------EEIEGRWKK 1027
++ L+ S+ E + L + +KE++ + + KYQ EE+ R
Sbjct: 3865 MRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALA 3924
Query: 1028 L------SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILK 1081
L S+Q+ E K+E + L + + ++ AEVD ++
Sbjct: 3925 LDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDK--------------IR 3970
Query: 1082 KQLKQCRLLVSDIQTIQPSLNSVNEGGQKI---KNEAEPEFASR-LETELKELNTQWDHM 1137
+ + + +++ +QPS ++ G+++ A+ + A++ ++ +L ++ W+ +
Sbjct: 3971 ECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDI 4030
Query: 1138 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1197
+ R+ LE D++ + + ++ + + P +++ VE +
Sbjct: 4031 KARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAE 4090
Query: 1198 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1257
KEE +++ + +I + ++K ++ + ++ L + + L
Sbjct: 4091 TIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKL 4150
Query: 1258 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1317
E+ + L+ WL+ KL T +P +++ V D L N M+ +
Sbjct: 4151 EDAMQAAVQYQDTLQAMFDWLDNTVIKLCT---MPPVGTDLNTVKDQL-NEMKEFKVEVY 4206
Query: 1318 QIRILAQTLTDGGVM----------DELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1367
Q +I + L G + ++I E L W L E+ RQ LE ++ +
Sbjct: 4207 QQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLA 4266
Query: 1368 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEEMK 1424
+ + +L + LT ++ L A D + E K +++D+ +H+ ++E +
Sbjct: 4267 LGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4326
Query: 1425 K------HNQGKEAAQRVLSQIDVAQKKLQDVSMKFR--------LFQKPANFEQRLQES 1470
K + + A + S+++ + + V K Q+ F +++
Sbjct: 4327 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDF 4386
Query: 1471 KMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR-QIVQKK 1529
+ L ++ L A + E + QL+ + LY L + ++ GR ++ +
Sbjct: 4387 LLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRD 4446
Query: 1530 QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDME 1589
+ + + ++ V L+ ++ + +K+ ERK +LE+ L L+ + + + WL +
Sbjct: 4447 DSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQS 4506
Query: 1590 LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKET-LVEDK 1648
L S + + + S++ K E+ + + + + G LK + K++ L+++
Sbjct: 4507 LNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNL 4566
Query: 1649 LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQ 1708
L + S W V R+ I+ LD++ +K+ +Q
Sbjct: 4567 LVSVQSRWEKVVQRS----------------------------IERGRSLDDA-RKRAKQ 4597
Query: 1709 KEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIK 1768
+ K+L L D +DS + ++N D
Sbjct: 4598 FHEAWKKLIDWLEDAESHLDSELE-----ISNDPD------------------------- 4627
Query: 1769 TGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGD 1828
K + L + ++F + + I+ G LKE+ + ++ + + E+ + D
Sbjct: 4628 --KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWD 4685
Query: 1829 NLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQW-YQYKRQADDLLK 1887
+ + + + + E + L S + AL+ W Y+ + Q +
Sbjct: 4686 TVCGKSVERQHKLEEAL--------------LFSGQFMDALQALVDWLYKVEPQLAEDQP 4731
Query: 1888 CLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA--AMAVEPTQ 1945
D++ + + D K+ +EL K+ + ++R L E+ V+
Sbjct: 4732 VHGDLDLVMNLM----DAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQL 4785
Query: 1946 IQLSKRWREI-ESKFAQFRRLNFA--QIHTVREETMMVMTEDMPLEISYVPSTYLTEITH 2002
+LS RW + + ++ RL A Q R+ M++ E + L + T
Sbjct: 4786 QELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTE 4845
Query: 2003 VSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 2062
Q+L++ + E + K EE ++ ++ + + H ++
Sbjct: 4846 ALQSLIDTHK------------EFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHW 4893
Query: 2063 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2122
+ R + +E L+ W K Q R + ++ + ++ W+ AE
Sbjct: 4894 ITIIRARFEEVLT-----WAK------QHQQRLETALSELVANAELLEELLAWIQWAETT 4942
Query: 2123 LRKTQ---IPENWEHAK-----YKWYLKELQDGIGQRQTVVRTLN--------------- 2159
L + IP+N + K ++ +++E+ V +T
Sbjct: 4943 LIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKS 5002
Query: 2160 -ATGEEIIQQSSKTDASILQE------KLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEF 2212
+ G + + Q + IL + ++ L+ RWQ+V +R+++L + + L E
Sbjct: 5003 RSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEEL 5062
Query: 2213 QRDLN-EFVLW 2222
+ N +F +W
Sbjct: 5063 KEFANFDFDVW 5073
Score = 91.3 bits (225), Expect = 2e-17
Identities = 111/555 (20%), Positives = 233/555 (41%), Gaps = 31/555 (5%)
Query: 327 GSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLT 386
G SL ++ ++ A ++++ WL AE L ++ EISND + +K Q H+ + L
Sbjct: 4585 GRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLG 4644
Query: 387 AHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 446
Q ++ G L L ED + ++ + + +W+ + S+E+Q L L+
Sbjct: 4645 GKQPVYDTTIRTGRALKEKTLLPEDSQ-KLDNFLGEVRDKWDTVCGKSVERQHKLEEALL 4703
Query: 447 DLQN--QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 504
L+ L DWL K E + E++P+ DL+ + + HKV Q++L + V
Sbjct: 4704 FSGQFMDALQALVDWLYKVEPQL--AEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQ 4761
Query: 505 SLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 564
L + E+S D T ++ QL+ L RW +C+ + + L+ L + + +
Sbjct: 4762 VLKRSGRELIENSRDD-TTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTV 4820
Query: 565 CLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSL-QKLAVLKADLEKKKQSMGKLYSLKQDL 623
+ WLSE E + D E L SL +E+K+ + ++ + +
Sbjct: 4821 HMLLEWLSEAEQTLR--FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVI 4878
Query: 624 LSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTT 683
L+ +T + W+ ++ ++ ++ ++ A+ ++ + E +
Sbjct: 4879 LAVCHPDCIT-TIKHWITIIRARFEEVLTWAKQHQQRLETAL--SELVANAELLEELLAW 4935
Query: 684 VTTREQILVKHAQEELPPPPPQKK-----RQITVDSEIRKRLDVD-ITELHSWITRSEAV 737
+ E L++ QE +P + K Q ++ RK+ DVD +T+ + R
Sbjct: 4936 IQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYK---RKNIE 4992
Query: 738 LQSPEFAIFRKEGNFSDLKE----KVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVN 793
F + G L + + + + +A+ R Q ++R Q + + +
Sbjct: 4993 PTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKL 5052
Query: 794 ADSIKQASEQLNSRWIEFCQLLSERLNWLEY-QNNIIAFYNQLQQLEQMTTTAENWL--- 849
D++ + E +F + + W+ + ++ ++ F+ ++ + + T + ++
Sbjct: 5053 NDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGI 5112
Query: 850 --KIQPTTPSEPTAI 862
PTT E TA+
Sbjct: 5113 LASKFPTTKLEMTAV 5127
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 325 bits (832), Expect = 7e-88
Identities = 545/2835 (19%), Positives = 1126/2835 (39%), Gaps = 316/2835 (11%)
Query: 338 DRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQ 397
++ QT LE L + + E+S ++ +F H+ ++ +L
Sbjct: 2219 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-----------EVLH 2267
Query: 398 LGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKE 455
K I + L D+ V E+ N L+ +++ + EK+ + + +D +K
Sbjct: 2268 SLLKEISSHGLPSDKAL-VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2326
Query: 456 LNDWLTKTEERTRKMEE----EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 511
L W+ +T ++ ++ E LG LED K+ ++ + ++++ SL +++
Sbjct: 2327 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2386
Query: 512 VVDESSGDHATAALEEQLKVLGDR---------WAN------------ICRWTEDRWVLL 550
V + A AA++ VL WAN I ED +LL
Sbjct: 2387 AVTTPA--KAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2444
Query: 551 QDI-------LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS-LQKLAVL 602
+D L K Q+ EE WL + K T E + + +++
Sbjct: 2445 KDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSF 2504
Query: 603 KADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS 662
+A+L KQ++ K+ LK L L+ T + W D+ Q+L + T
Sbjct: 2505 EAEL---KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEI-DSKWQELNQLTIDRQ 2560
Query: 663 QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV 722
Q + + +LTQ +E
Sbjct: 2561 QKLEESSNNLTQFQTVEA------------------------------------------ 2578
Query: 723 DITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 782
+L W+ E ++ S + + +++V + +E A + + + + + Q
Sbjct: 2579 ---QLKQWLVEKELMV-SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2634
Query: 783 LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQN-NIIAFYNQLQQLEQM 841
++ + + +K+ + +W LS+R +W++ + + L+ L
Sbjct: 2635 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2694
Query: 842 TTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQ----SIALKEKG 897
+ +N L + P A+ QL+ + + + QI+ + S +KE+
Sbjct: 2695 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE- 2753
Query: 898 QGPMFLDADFVAFTNHFKQVFSDVQAR-EKELQTIFDTLPPM-RYQETMSAIRTWVQQSE 955
+L A+ + F DV+ + E +Q + ++Q+ + W+ +
Sbjct: 2754 ----YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2809
Query: 956 TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 1015
+ + +++E + + + +L Q + + K Q
Sbjct: 2810 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2869
Query: 1016 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW---- 1071
+ I+ W + Q+ E KL+E + K K + ++TL W+ + L+E
Sbjct: 2870 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2929
Query: 1072 PALGDSEI-----LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE 1126
PA G++ I L+K++ Q +V + SL SV E +++ + E
Sbjct: 2930 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-----------E 2978
Query: 1127 LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD------ 1180
K L + D + +Q++++K L+ +K Q+ E + A+E+ D
Sbjct: 2979 NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA 3038
Query: 1181 FEYKTPDELQKAVEEMKRAKEEAQ-QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETL 1239
+ K LQ + ++ K + K L+ E+ +S + E + +E TL
Sbjct: 3039 YSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL 3098
Query: 1240 TTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEIS 1299
+ C+ L K + + E+ S + + L+ + + E + E I
Sbjct: 3099 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIK 3158
Query: 1300 EVLDSLENLMRHSEDNPNQI--RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRR 1357
L LE LM S DN N+ +LA T ++ I +LE + + +L + A R
Sbjct: 3159 AFLKKLEALMA-SNDNANKTCKMMLATEETSPDLVG--IKRDLEALSKQCNKLLDRAQAR 3215
Query: 1358 QKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMP--QEAQKIQSDLTS 1415
++ +E +I+ +E L +E + K A++ + +Q P E + I L
Sbjct: 3216 EEQVEGTIKRLEEFYSKL---KEFSILLQK------AEEHEESQGPVGMETETINQQLNM 3266
Query: 1416 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 1463
++ +E + QGK+ L Q I A K L DV+ +++ L +K A
Sbjct: 3267 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3326
Query: 1464 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 1509
+LQE+ + + L +L + S E +VV++Q+ L + L
Sbjct: 3327 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3386
Query: 1510 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 1569
+ KS VE++ + G +I + + ++ ++++ L + L K R +QLE ++
Sbjct: 3387 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3446
Query: 1570 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 1629
++ + + L EWL + L + S L+ ++A KA + +I HL
Sbjct: 3447 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3506
Query: 1630 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1688
+G++LK + +++ +V+ KL +I + ++ LL + + + F ++ +
Sbjct: 3507 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3566
Query: 1689 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 1748
W+ + L S+ + L + ++EL ++ + + + N + ++
Sbjct: 3567 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3624
Query: 1749 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 1796
++ + + AI R K T ++ K LEQ ++L L+ +E E
Sbjct: 3625 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3684
Query: 1797 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 1846
+ + LK E+ + K++ ++ N + + L + + R RE ++
Sbjct: 3685 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3744
Query: 1847 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1906
++ + D +Q+ ++ + Q+ + AD L + + EKKL SL + R E+
Sbjct: 3745 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3804
Query: 1907 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1966
+ +LQ +K + R + + D + S+ ++ K N
Sbjct: 3805 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3860
Query: 1967 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 2026
+ I + E + + L ++ TY + L E + +++ A ++E
Sbjct: 3861 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 3915
Query: 2027 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2086
L +Q+E + +++ + + ID ++ K L +P E +QE D + ++ +
Sbjct: 3916 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3974
Query: 2087 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 2144
K R D ++ + +FH I +Q L E+ + + + P + E K K + E
Sbjct: 3975 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 4031
Query: 2145 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 2197
++ + + Q + TL GEE+I +S TD I +Q+KL + W+ + + +
Sbjct: 4032 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4091
Query: 2198 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 2256
R+ +L + + +F D ++ +++ + +PG + + K++ E + + EE+
Sbjct: 4092 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4151
Query: 2257 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 2314
Q L + G ++ + E DK ++ + + N W +++A ++ ++E
Sbjct: 4152 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 4207
Query: 2315 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2371
++ Q + L+ D + L +SPI LE Q +E +++ + +
Sbjct: 4208 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 4263
Query: 2372 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 2431
Q ++E + + + L K K + K ++D E K + L+E
Sbjct: 4264 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 4307
Query: 2432 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 2491
++ ++ KLE +L+ AL F A EL WL+ + ++
Sbjct: 4308 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 4345
Query: 2492 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2551
Q+ + GD + I + K D+ + +E + A +L ++ +EA + +++E
Sbjct: 4346 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4404
Query: 2552 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2611
+ +W V E + R+QQL+ L+ + + E+ +Q L L + K +
Sbjct: 4405 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4464
Query: 2612 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2671
++++ ++ + ++L + N+ W S+
Sbjct: 4465 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4524
Query: 2672 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 2731
+++ER+ LEE L +F L+ F+ WLT+AE T NV A+R +L+ V +
Sbjct: 4525 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4578
Query: 2732 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 2791
+ + E+ +H + LD+ L+ D VL++ L ++ +W ++ ++ +
Sbjct: 4579 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4637
Query: 2792 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 2851
L+ + + K+ H + +L+ WL+ + L + I D ++ Q H+ F++ L
Sbjct: 4638 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4697
Query: 2852 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 2911
K V +T T R L + + L E+ +W
Sbjct: 4698 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4738
Query: 2912 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 2970
+ + S + Q K++E L + +A L L + E QPV GD ID + +
Sbjct: 4739 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4796
Query: 2971 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 3023
++ KA + E+ +V + AR+L S + +++L+TRW+ +
Sbjct: 4797 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4856
Query: 3024 QVAVEDRVRQLHEAH 3038
Q +E +RQ E H
Sbjct: 4857 QTRLEAALRQAEEFH 4871
Score = 325 bits (832), Expect = 7e-88
Identities = 536/2814 (19%), Positives = 1113/2814 (39%), Gaps = 346/2814 (12%)
Query: 330 LMESEVNLDRYQTALEE---VLSWL--LSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD 384
+ E L + Q A EE ++ WL ++ T Q D E VK Q ++ + +
Sbjct: 2448 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2507
Query: 385 LTAHQGRVGNILQLGSKLIGTGKLSEDEETEV----QEQMNLLNSRWECLRVASMEKQSN 440
L + V + +L KL T L E+ +T ++ + ++S+W+ L ++++Q
Sbjct: 2508 LKQN---VNKVQELKDKL--TELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2562
Query: 441 LHRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQ 498
L +L + E L WL + E + PL D L Q QQ ++L ++
Sbjct: 2563 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLG--PLSIDPNMLNTQRQQVQILLQEFAT 2620
Query: 499 EQVRVNSLTHMVVVVDESSGDHAT--AALEEQLKVLGDRWANICRWTEDRWVLLQDILLK 556
+ + LT + G+ + ++EQL + +W ++ DR + ++K
Sbjct: 2621 RKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVK 2680
Query: 557 WQRLTEEQCLFSAWLSEKEDAVNKIHT-----TGFKDQNEMLSSLQKLAVLKADLEKKKQ 611
T+ Q L + + D NK+ + T N+ L + QK+ K +++++K+
Sbjct: 2681 ---STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKM---KQEIQQEKK 2734
Query: 612 SMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ-- 669
+ +L +DL + +K + + + L+ + + ++ QK E + A ++
Sbjct: 2735 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2794
Query: 670 ----------------------PSLTQTTVMETVT-------------------TVTTRE 688
P + V+E++ T+ E
Sbjct: 2795 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2854
Query: 689 QILVKHAQEELPPPPPQ---------------KKRQITVDSEIRKRLDV--DITELHSWI 731
+L+K E Q K+R+ + + K L + L WI
Sbjct: 2855 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 2914
Query: 732 TRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV------- 784
+ + L+ +F + EG S K K ++++E + F ++ + +A +L+
Sbjct: 2915 DKCQNNLEEIKFCLDPAEGENSIAKLK--SLQKEMDQHFGMVELLNNTANSLLSVCEIDK 2972
Query: 785 EQMVNEGVNA-DSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 843
E + +E + + +EQL+S+ +FC L + + E+Q QLQ ++
Sbjct: 2973 EVVTDENKSLIQKVDMVTEQLHSK--KFC-LENMTQKFKEFQEVSKESKRQLQCAKEQLD 3029
Query: 844 TAEN---------WLKIQPTTPSEPTAIKSQLKICKDEVNRL----------SGLQPQIE 884
++ +L + T A+K Q+ + K L S + Q+E
Sbjct: 3030 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE 3089
Query: 885 RLKIQSIALKEK-GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPM-RYQE 942
+ + L ++ + FL+ HF+ ++ ++ E D++ P+ R E
Sbjct: 3090 TIAQEHSTLSQQVDEKCSFLETKLQGI-GHFQNTIREMFSQFAEFDDELDSMAPVGRDAE 3148
Query: 943 TMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEM 1002
T+ + ++ KL S + + + +E L + ++ +
Sbjct: 3149 TLQKQKETIKAFLKKLEALMAS-------NDNANKTCKMMLATEETSPDLVGIKRDLEAL 3201
Query: 1003 SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1062
SK+ + R Q+ E++EG K+L E KL+E L+K + H ++
Sbjct: 3202 SKQCNKLLDRA-QAREEQVEGTIKRLE----EFYSKLKEFSILLQKAEEHEES------- 3249
Query: 1063 VDVFLKEEWPALGDSEILKKQLKQCRLLVSD-IQTIQPSLNSVNEGGQK-IKNEAEPEFA 1120
+ P ++E + +QL ++ + I+ +Q VN GQ I++ A+
Sbjct: 3250 -------QGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTST 3302
Query: 1121 SRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD 1180
LE +L ++N +W + ++V R L+ L Q L + WM EE +
Sbjct: 3303 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3362
Query: 1181 FEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLT 1240
++ ++E K + +++ V+++ + A P + + K+L L
Sbjct: 3363 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3422
Query: 1241 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1300
+ ++ L + + + LE + + LE N+WL +E +L E I A ++ E
Sbjct: 3423 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3482
Query: 1301 VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELET-------FNSRWR-ELHE 1352
+ + L +D N + L Q ++ G + L + E + F+ W E+ E
Sbjct: 3483 QIAQHKAL---EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3539
Query: 1353 EAVRRQKLLEQSIQSAQET-EKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK--I 1409
++ R +LL+Q++ +A+ E + L+ DK + D Q+++ +
Sbjct: 3540 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3599
Query: 1410 QSDLTSHEISLEEMKKHNQGKEAAQRVLS-QIDVAQKKLQDVSMKFRLFQKPAN-----F 1463
Q D+ + ++++ + G E ++ ++ + Q KL+ + +++ K +
Sbjct: 3600 QEDILLRKQNVDQALLN--GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3657
Query: 1464 EQRLQESKMI----------LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1513
EQ LQ ++ + LD+V++ L + ET+ ++ E L K K+
Sbjct: 3658 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKA 3717
Query: 1514 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1573
++ + + +++ + L++ V Y + +T++ ++++ + S++
Sbjct: 3718 LLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFD 3777
Query: 1574 KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEA 1633
+ + W+ T+ +L + +++ K EI + K + + + G
Sbjct: 3778 QAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHK 3837
Query: 1634 LKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWII 1692
+ T ++E ++ KL + N+ + E L Q + F + + + W+
Sbjct: 3838 IMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT 3897
Query: 1693 QADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRGDH 1744
+ +++ E E + QQ+E L+ L AE K++ T Q L G
Sbjct: 3898 ETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS 3957
Query: 1745 CRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ--- 1799
++ + + ++ I +K ++ + + QF+ I ++LE LE +++
Sbjct: 3958 ----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4013
Query: 1800 --GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIKQQ 1848
++ + E + ++E+ +V + L QRG+ + R K K Q
Sbjct: 4014 PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 4073
Query: 1849 LLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-D 1904
L + L +R K L++ ++ L+ + D + + L +P D
Sbjct: 4074 KLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4133
Query: 1905 ERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKFAQ 1961
+K+ + +EE++ ++ + + L + A EP + + K E+ S +
Sbjct: 4134 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDS 4193
Query: 1962 FRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCA 2021
+ +I + EE M + Y + V + L +
Sbjct: 4194 LNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSPIG 4240
Query: 2022 KDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLDFQ 2080
D E + +Q E LK K Q ++ ++ + L+ T ++ +Q+ L +L
Sbjct: 4241 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 4300
Query: 2081 WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 2140
W+ + + +RQ + + ++ +F + + WLT E L + Q P + +
Sbjct: 4301 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIEIE 4359
Query: 2141 LKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSD 2197
L + LQ+ + Q+ V +N G ++I+ S+ +AS LQ KL LN RWQ V ++
Sbjct: 4360 LAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQ 4419
Query: 2198 RKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLVEE 2255
RK++L+ F ++ + WL + + +AS PL G + KE+L +
Sbjct: 4420 RKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVCAA 4478
Query: 2256 LPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEIEA 2314
++ K L + G +L P S E D+ N LK+ +W V L E++ ++E
Sbjct: 4479 FEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKLEE 4535
Query: 2315 QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---AV 2368
+ + L+D + WL+ L + ++P+ F + E ++ V
Sbjct: 4536 ALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4588
Query: 2369 QAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDLAP 2425
+ + + E+ G HL + +K +K L + S W K V RL++ R
Sbjct: 4589 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR-------- 4640
Query: 2426 GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLL 2485
SL F+ AW++L +WL
Sbjct: 4641 ----------------------------------SLDDARKRAKQFHEAWSKLMEWLEES 4666
Query: 2486 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI 2545
++ + S+ + D + I + + K + L + + ++LK KTS +
Sbjct: 4667 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4726
Query: 2546 ITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEG 2605
+ D + ++++WD + R+ +L E L S Q+ +A + L + +L +
Sbjct: 4727 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4786
Query: 2606 PYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINAS 2665
+D + I K K+L + ++V A +L+ S DD+ V + + ++
Sbjct: 4787 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELSTR 4845
Query: 2666 WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERLLE 2722
W ++ ++ LE R ++F + L WL EAE T VL D R L
Sbjct: 4846 WETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLI 4905
Query: 2723 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 2782
D KE MK+ ++ + E+ T + + ++ D ++ + + ++
Sbjct: 4906 DQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRARF 4955
Query: 2783 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQKQ 2840
E+ + + L ++ L+ LL WLQ + L+ + I + V+
Sbjct: 4956 EEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKAL 5015
Query: 2841 NDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LYQE 2883
H+ F E+ K+P + +T + I + ++ G ++ LY
Sbjct: 5016 IAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPS 5075
Query: 2884 PRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2937
+ E + V L+ K W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 5076 GSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 5121
Score = 316 bits (809), Expect = 3e-85
Identities = 546/2809 (19%), Positives = 1127/2809 (40%), Gaps = 353/2809 (12%)
Query: 337 LDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 396
L+++ E WL +E L+ ++D+ + + + + D+ +H+G + I
Sbjct: 1868 LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT 1927
Query: 397 QLGSKLIGTGKLSEDEE----------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 446
G++++ K + EVQ +++ R+ L +NL ++
Sbjct: 1928 ISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVD 1987
Query: 447 DLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 504
Q+ + L L E K EP+ D ++L+RQ+++ K LQ + +QV V
Sbjct: 1988 KYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE 2047
Query: 505 SLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRWVLLQDILLKWQRLT 561
L V+ ++ G A + Q K L D R+ ++ + +R LQ L + +
Sbjct: 2048 KLKKTAEVLLDARGSLLPAKNDIQ-KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2106
Query: 562 EEQCLFSAWLSEKEDAVNK-----IHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 616
+ W+ E ++ + +++T +D + K +L+ D+ ++ S+ +
Sbjct: 2107 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQD------IISKNIMLEQDIAGRQSSINAM 2160
Query: 617 YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTT 676
+ + T + S +A + + + + K +++ A++ + T + L +
Sbjct: 2161 NEKVKKFMETT-DPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVE--LFENL 2217
Query: 677 VMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDS-----EIRKRLDVDITELHSWI 731
+ T + T+ Q L + ++P + Q +S E +K L+V LHS +
Sbjct: 2218 SEKLQTFLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHKKHLEV----LHSLL 2270
Query: 732 TR-SEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE 790
S L S + + K N S +KF++++D + +
Sbjct: 2271 KEISSHGLPSDKALVLEKTNNLS--------------KKFKEMEDTIKEKK--------- 2307
Query: 791 GVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK 850
+++ EQL++ F L+ +W++ + E + + E+ K
Sbjct: 2308 ----EAVTSCQEQLDA----FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2359
Query: 851 IQPT----TPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKG--------- 897
+Q TP S + +C + ++ ++ I +K L +G
Sbjct: 2360 LQEKWSLKTPEIQKVNNSGISLC-NLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2418
Query: 898 --QGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQ-S 954
+G + D ++ ++ + ++ + EL T L + QE SA+ W+Q+ +
Sbjct: 2419 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--QKAQEESSAMMQWLQKMN 2476
Query: 955 ETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISR 1012
+T Q TD E ++ ++ + ++ ++ L++ + + L + E+ ++ P + +
Sbjct: 2477 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2536
Query: 1013 KYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 1072
+++ EI+ +W++L+ ++ QKLEE N L + Q LK+W+ E ++ + P
Sbjct: 2537 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2596
Query: 1073 ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA--EPEFASRLETELKEL 1130
D +L Q +Q ++L+ + T +P + GQ I + +P ++ +L +
Sbjct: 2597 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2656
Query: 1131 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1190
+WD + Q+ R + + + K+ Q L + + ++ + + PD +
Sbjct: 2657 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN 2716
Query: 1191 KAVEEMKRAKEEAQQKEAKVKL---LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLC 1247
+ +E ++ K+E QQ++ ++K+ L E +++++ + A+ L ++LE + +++ +
Sbjct: 2717 QQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--LSRQLEGILKSFKDVE 2774
Query: 1248 TRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLEN 1307
+ + L+ A H+ WL+ T + + IS LD LE+
Sbjct: 2775 QKAENHVQHLQSACASSHQFQQMSRDFQAWLD-------TKKEEQNKSHPISAKLDVLES 2827
Query: 1308 LMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1367
L++ +D ++TLT M E E E + + + A++ Q
Sbjct: 2828 LIKDHKD-------FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--------- 2871
Query: 1368 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN 1427
L+ I+ + +KQ+ + K++ SLE+ K+
Sbjct: 2872 -------LNTIKTNWDTFNKQVK-------------ERENKLKE-------SLEKALKY- 2903
Query: 1428 QGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETK 1487
KE + + ID Q L+++ KF L PA E + + K + E+ H +E
Sbjct: 2904 --KEQVETLWPWIDKCQNNLEEI--KFCL--DPAEGENSIAKLKSLQKEMDQHFGMVEL- 2956
Query: 1488 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK-----KQTENPKELDERVT 1542
LN+ N S+ E+ EV V + ++QK +Q + K E +T
Sbjct: 2957 ----------LNNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHSKKFCLENMT 3004
Query: 1543 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1602
+ E+ E K+QL+ C K + + M T++ +++ +
Sbjct: 3005 QKFKEFQEVSK---ESKRQLQ-CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3060
Query: 1603 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL---VEDKLSLLNSNWIAV 1659
+D K +++ + K ++V ++T+ + TL V++K S L + +
Sbjct: 3061 VDL----AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3116
Query: 1660 TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE-DVLKRLKA 1718
+ N + E FD +D + A+TL + E K K+ + L
Sbjct: 3117 G----HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3172
Query: 1719 ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 1778
N + +T + + +L+ + D + + Q ++L R A +++ +K
Sbjct: 3173 NANKTCKMMLATEETSPDLVGIKRD--LEALSKQCNKLLDRAQAREEQVEG-----TIKR 3225
Query: 1779 LEQFNSDIQK---LLEPLEA--EIQQGVNLKEEDFNKDMN----------EDNEGTVKEL 1823
LE+F S +++ LL+ E E Q V ++ E N+ +N E +G +++
Sbjct: 3226 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3285
Query: 1824 LQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQAD 1883
G L Q + ++ + + L +QR + E +++ +
Sbjct: 3286 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3345
Query: 1884 DLLKCLDDIEKKLASLPEPRDERKI--------KEIDRELQKKKEELNAVRRQAEGLSED 1935
LL + D E+ +A+ P E K+ K + R L +K + ++R+ E +
Sbjct: 3346 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI--- 3402
Query: 1936 GAAMAVEPT-QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-ISYVP 1993
A EP ++++ K+ ++S++ LN A+ T + LE IS V
Sbjct: 3403 --ATTAEPADKVKILKQLSLLDSRWEAL--LNKAE------------TRNRQLEGISVVA 3446
Query: 1994 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 2053
+ + +++ L +E+ L + L +Q K ++D + + + H
Sbjct: 3447 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL---HQ 3503
Query: 2054 KKTAALQSATPVERVKLQEALSQLDFQ---WEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 2110
+ R S+LDF + ++ + R +++ + F D
Sbjct: 3504 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEV 3563
Query: 2111 IFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQDGIGQRQTVVRTLNATGEEIIQQ 2168
WL E L K + + +K L+ LQ+ I R+ V G E+++Q
Sbjct: 3564 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3623
Query: 2169 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD- 2227
++ + I+Q+KL ++ R++++ K +D K LE+ + E WL++ +
Sbjct: 3624 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3683
Query: 2228 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2287
+ S + K ++ + + K L +E + +L LNE +L P E L
Sbjct: 3684 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG--L 3741
Query: 2288 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2347
E + + N ++ VS + +K EI+A I + + ++ + L W++ +L
Sbjct: 3742 EKMVAEDNERYRLVSDTITQKVEEIDAAIL-------RSQQFDQAADAELSWITETEKKL 3794
Query: 2348 EIYN-----QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK---EKPATQPVKRKL 2399
Q VQ+T + D+ + L K H + Q +K+KL
Sbjct: 3795 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3854
Query: 2400 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2459
+ + + + ++ E R Q + A +LV Q T E L
Sbjct: 3855 DKVLKNYDTICQINSE-RYLQLERAQ-------------SLVNQFWETYEELWPWLTETQ 3900
Query: 2460 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2519
S++ ++PA A L + ++ Q+ + + E+I + K + + +
Sbjct: 3901 SIISQLPAPA--------------LEYETLRQQQE---EHRQLRELIAEHKPHIDKMNKT 3943
Query: 2520 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2579
PQL EL S E +I ++ + +++E ++ R L+E + ST
Sbjct: 3944 GPQLLEL-----------SPGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQST 3991
Query: 2580 QWLEAKEEAEQVLGQARAKLESWKEGPYT---VDAIQKKITETKQLAKDLRQWQTNVDVA 2636
Q+ ++ +Q+L +E ++ P V+ I+++I+E K ++ D+ + Q +
Sbjct: 3992 QF---HDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 4048
Query: 2637 NDLALKLL-RDYSADDTRKVHMITENINAS---WRSIHKRVSEREAALEETHRLLQQFPL 2692
+++ R D + + ++ W +IH V EREA L + L ++F
Sbjct: 4049 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC 4108
Query: 2693 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD-LQGEIEAHTDVYHNL 2751
D + + + + L+D +++ + E +++ D LQ E+ D+ NL
Sbjct: 4109 DHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEEL----DIVINL 4164
Query: 2752 DENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 2811
L + G D ++++ +D +N W L K + LE + + LQ
Sbjct: 4165 GSE----LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4220
Query: 2812 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 2871
+ W+ + +L+ +PIG D V++Q + + FK E +
Sbjct: 4221 AVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAY------------------Q 4262
Query: 2872 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 2931
Q +E +E+L + L + ++ ++ E+ W+ L + Q K++ L
Sbjct: 4263 QQIE-MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4321
Query: 2932 LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 2991
L + Q A DEL L E + +PVG +++ L K L+ ++ + V V
Sbjct: 4322 LGQFQHALDELLAWLTHTEGLLSEQKPVGG-DPKAIEIELAKHHVLQNDVLAHQSTVEAV 4380
Query: 2992 NDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 3039
N L NL + LE LN RW+ + E R +QL A R
Sbjct: 4381 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4429
Score = 313 bits (803), Expect = 2e-84
Identities = 505/2706 (18%), Positives = 1066/2706 (39%), Gaps = 308/2706 (11%)
Query: 399 GSKLIGTGKLSEDEE-------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN- 450
G+ L G G + EE T +++ M ++ +E L + +K + L+ L LQ
Sbjct: 2402 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2461
Query: 451 -QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 509
++ + WL K + K ++ P D E +K QV+Q+K + +L+Q +V L
Sbjct: 2462 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2521
Query: 510 VVVVDESSGDHATAALEEQ-LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 568
+ + E + D A +Q L + +W + + T DR L++ + +
Sbjct: 2522 LTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLK 2581
Query: 569 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL- 627
WL EKE V+ + D N + + Q++ +L + +K +L + Q +LS
Sbjct: 2582 QWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2640
Query: 628 KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 687
++ S+ + L + WD+L +L I QA+ + T+
Sbjct: 2641 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS-----------------TQ 2683
Query: 688 EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFR 747
Q L++ ++L +D+++ L V T +A+ Q E A
Sbjct: 2684 YQSLLRSLSDKLSD----------LDNKLSSSLAVS--------THPDAMNQQLETAQKM 2725
Query: 748 KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK-QASEQLNS 806
K+ I++EK + + AQAL E + + V + +K + S QL
Sbjct: 2726 KQ-----------EIQQEKKQ--------IKVAQALCEDL-SALVKEEYLKAELSRQLEG 2765
Query: 807 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ-----MTTTAENWLKIQPTTPSEPTA 861
F + + N +++ + A +Q QQ+ + + T E K P + ++
Sbjct: 2766 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS-AKLDV 2824
Query: 862 IKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFS 919
++S +K KD L+ E+ + +++ LK +G L ++
Sbjct: 2825 LESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2884
Query: 920 DVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQ 979
V+ RE +L+ + ++Y+E + + W+ + + L + + E E + +L+
Sbjct: 2885 QVKERENKLKESLEKA--LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE-GENSIAKLK 2941
Query: 980 ALQSSLQEQQSGLYYLSTT------VKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLV 1033
+LQ + + + L+ T V E+ K+ ++ ++ + + + + L
Sbjct: 2942 SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLE 3001
Query: 1034 EHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD 1093
QK +E ++ + +Q K+ ++D+ +LG K L +
Sbjct: 3002 NMTQKFKEFQEVSKESKRQLQCAKE---QLDIH-----DSLGSQAYSNKYLTMLQTQQKS 3053
Query: 1094 IQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQWDHMCQQVYARKEALKGGL 1152
+Q ++ ++ Q + EA + + S + +++ + + + QQV + L+ L
Sbjct: 3054 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3113
Query: 1153 EKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR---------AKEEA 1203
+ Q + EM + ++E + + LQK E +K A +
Sbjct: 3114 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN 3173
Query: 1204 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1263
K K+ L TE + + +K++LE L+ L R + + +E
Sbjct: 3174 ANKTCKMMLATEETSPDLV--------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3225
Query: 1264 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHS----EDNPNQI 1319
E S L++ + L + E ++ + E I++ L+ + + + +
Sbjct: 3226 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3285
Query: 1320 RILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI------QSAQE 1370
L Q L + + +L+ N+RW+ L+++ +R L++++ Q A E
Sbjct: 3286 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3345
Query: 1371 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK 1430
+ S + E L K +A KV AQ+ QE + +Q L + ++E +K+ +
Sbjct: 3346 SLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QEQKLLQRLLDDRKSTVEVIKREGEKI 3402
Query: 1431 EAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI--------LDEVKMHLP 1482
++ + K+L + ++ A R E + L+ + L
Sbjct: 3403 ATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3461
Query: 1483 ALETKSVEQEVVQSQ---LNHCVNLYKSLSEV----KSEVEMVIKTGRQIVQKKQTENPK 1535
+E + V E + +Q L + +K+L + + + G+ + E+
Sbjct: 3462 TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3521
Query: 1536 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1595
+ ++ ++ Y E+ K R + L++ L ++ ++ L WL +L+K S
Sbjct: 3522 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV 3581
Query: 1596 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNS 1654
+ L + + + Q++I +K ++ G E LK G + +++DKL + +
Sbjct: 3582 QDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3641
Query: 1655 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDV 1712
+ +T + + L + + + + W+ ++ + L E++ K ++
Sbjct: 3642 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3701
Query: 1713 L---KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI-- 1767
K LK E + + +DS + ++ L+ R+ +E ++E N R+ +S I
Sbjct: 3702 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3761
Query: 1768 KTGKASIPLKELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED- 1815
K + + +QF+ +KL+ + ++Q + K +
Sbjct: 3762 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3821
Query: 1816 --NEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISH 1873
++ + +L++ G + ++E K + +K K + ++ + + S+R +
Sbjct: 3822 LRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3880
Query: 1874 QWYQYKRQADDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEEL 1922
Q+ ++L L + + ++ LP P + R+++E+ E + +++
Sbjct: 3881 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3940
Query: 1923 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1982
N Q LS G +++ + + +I+ ++ A + + T
Sbjct: 3941 NKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDK 3996
Query: 1983 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 2042
D LE L + +S + ++++ ++ + D E L E+LK + +
Sbjct: 3997 IDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMI 4056
Query: 2043 QSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW 2102
SG D S K +Q+ L Q+ F WE ++ + ++R+ + +E
Sbjct: 4057 ARSGGTDKDISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 4103
Query: 2103 RRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTV 2154
+F D + + + F+R + P + E A+ ++E DG+ + +
Sbjct: 4104 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDI 4160
Query: 2155 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2214
V L G E+I + D I+++ + LN W + K DR +LEE ++Q
Sbjct: 4161 VINL---GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 4217
Query: 2215 DLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV 2273
L W++ A +AS+ + +K+++E++K E +Q +++LN +
Sbjct: 4218 GLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELL 4277
Query: 2274 LVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEE 2331
L EE DK +++ L + L W + + +Q ++E + LGQ + L++L
Sbjct: 4278 LKKVT---EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-- 4332
Query: 2332 QLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQ 2383
L WL+ L Q G E E+A V A Q VE + G
Sbjct: 4333 -----LAWLTHTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGN 4385
Query: 2384 HLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2441
L + + ++ KLE L+ W+ V
Sbjct: 4386 DLIESSAGEEASNLQNKLEVLNQRWQNV-------------------------------- 4413
Query: 2442 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2501
++T K ++ +L F+ +L WL+ ++ + + + + G E
Sbjct: 4414 -----LEKTEQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4464
Query: 2502 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2561
E + E + + L+ Q + + + A T I I ++ +W+ V+
Sbjct: 4465 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVE 4523
Query: 2562 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2621
L R+ +L E L + ++ + ++ L QA L +D + +I E K
Sbjct: 4524 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4583
Query: 2622 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2681
A ++ + + + L D + + ++ + W + +R+ ER +L+
Sbjct: 4584 FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLD 4643
Query: 2682 ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2741
+ + +QF K + WL E+E + + + + D +K + Q ++ Q +
Sbjct: 4644 DARKRAKQFHEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSL 4697
Query: 2742 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSD 2801
A VY + + + +DD + L L + KW + KS+ ++ LE +
Sbjct: 4698 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4757
Query: 2802 QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 2861
+ +LQ L+ WL + +L+ P+ GD V D H+AF++EL +
Sbjct: 4758 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT------ 4811
Query: 2862 LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 2921
++ L + REL E +++ + ++ Q +E++T WE + S
Sbjct: 4812 -------------SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISK 4856
Query: 2922 QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVK 2975
Q +++ L + +E L L +AE + D LID ++ ++K++
Sbjct: 4857 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4916
Query: 2976 ALRGEI 2981
R E+
Sbjct: 4917 EKRAEL 4922
Score = 277 bits (708), Expect = 2e-73
Identities = 491/2725 (18%), Positives = 1089/2725 (39%), Gaps = 258/2725 (9%)
Query: 341 QTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGS 400
Q L+E+L W+ + E +L+ QG++ + ++D + D+ Q + + +
Sbjct: 2106 QDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2165
Query: 401 KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKELND 458
K + T S + +Q +M L++R+ E + + + ++L ++L
Sbjct: 2166 KFMETTDPST--ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2223
Query: 459 WL-TKTEERTRKMEEEPLGPDLEDLKRQVQQ-------HKVLQEDLEQEQVRVNSLTHMV 510
+L TKT+ T E + G D+ +L + +Q+ HK + LE + ++
Sbjct: 2224 FLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHK---KHLEVLHSLLKEISSHG 2277
Query: 511 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 570
+ D++ T L ++ K + D + ++ Q+ L +Q L + +W
Sbjct: 2278 LPSDKALVLEKTNNLSKKFKEMEDT----IKEKKEAVTSCQEQLDAFQVLVKS---LKSW 2330
Query: 571 LSEKEDAVNKIHTT-GFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 629
+ E V + + G +D + L +KL + +SLK + + N
Sbjct: 2331 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQ--------------EKWSLKTPEIQKVNN 2376
Query: 630 KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQ--AVTTTQPSLTQTTVMETVTTVTT- 686
++ L N + V K+ A + AV + + T T +T+
Sbjct: 2377 SGIS------LCNLI----SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2426
Query: 687 -REQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL----QSP 741
++ + H E+L K ++ ++ + + + W+ + Q+P
Sbjct: 2427 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2486
Query: 742 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 801
A E + +++ + E E + K+Q+ L+E+ + A KQ
Sbjct: 2487 --APTDTEAVKTQVEQN-KSFEAELKQNVNKVQELKDKLTELLEENPDTP-EAPRWKQML 2542
Query: 802 EQLNSRWIEFCQLLSERLNWLEYQ-NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 860
+++S+W E QL +R LE NN+ F QL+Q E + + +P
Sbjct: 2543 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2602
Query: 861 AIKSQLKICKDEVNRLSGLQPQIERLKIQSIA-LKEKGQGPMF---LDADFVAFTNHFKQ 916
+ +Q + + + + +PQ E+L L G+ P + A T +
Sbjct: 2603 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2662
Query: 917 VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 976
+ + R + + +YQ + ++ + + KLS T + M Q+L
Sbjct: 2663 LTGQLSDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLE 2720
Query: 977 ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSE-ISRKYQSEFEEIEGRWKKLSSQLVEH 1035
Q ++ +Q+++ + +++S E + + + E I +K + + H
Sbjct: 2721 TAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH 2780
Query: 1036 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1095
Q L+ + Q + + W+ + P ++L+ +K + +
Sbjct: 2781 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2840
Query: 1096 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1155
G+ + + + + L+ +L + T WD +QV R+ LK LEK
Sbjct: 2841 AQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 2900
Query: 1156 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTE 1215
+ ++ + + W+ + + E F P E + ++ ++K ++E Q V+LL
Sbjct: 2901 LKYKEQVETLWPWIDKCQNNLEEIKF-CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNN 2959
Query: 1216 SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKAN 1275
+ NS+++ + +E + E ++L + +L+ K LE + + E +++
Sbjct: 2960 TANSLLSVCE-IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESK 3018
Query: 1276 KWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI---LAQTLT----- 1327
+ L + +L +++ G ++ L L+ + + +Q+ + LAQ L
Sbjct: 3019 RQLQCAKEQLDIHDSL-GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD 3077
Query: 1328 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1387
G D L+ ++ET L ++ + LE +Q + ++ + D
Sbjct: 3078 SKGTSDVLL--QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD 3135
Query: 1388 QLAAYIADKVDAAQMPQEAQKIQSDLTSHE----------------ISLEEMKKHNQGKE 1431
+L + DA + ++ + I++ L E ++ EE G +
Sbjct: 3136 ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3195
Query: 1432 AAQRVLSQ-----IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALET 1486
LS+ +D AQ + + V + ++ F +L+E ++L + + H +
Sbjct: 3196 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE---FYSKLKEFSILLQKAEEHEESQGP 3252
Query: 1487 KSVEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTAL 1544
+E E + QLN K + ++ + + V G+ ++Q ++ + + L+ + +
Sbjct: 3253 VGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDV 3312
Query: 1545 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1604
+ L KV +R QL++ L + + + L W+ T+ + + +
Sbjct: 3313 NARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK 3372
Query: 1605 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRA 1663
+++ K Q+ ++ +K ++ I GE + T + + + +LSLL+S W A+ ++A
Sbjct: 3373 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3432
Query: 1664 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELN 1721
E L + F + ++ + +W+ + L E Q E+ + + KA +
Sbjct: 3433 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3492
Query: 1722 DIRPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL 1776
DI Q+ ++++R D + +V+ ++ F+ + + I+ + S
Sbjct: 3493 DIINHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSR 3544
Query: 1777 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRI 1834
EL Q K+ E E+ +N + +K +D EG K+ + R+
Sbjct: 3545 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRV 3598
Query: 1835 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1894
E + + KQ + Q N L+ L+ + L I + K + D+ K D+ K
Sbjct: 3599 LQE---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3655
Query: 1895 KLASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRW 1952
L + R++ EL K E+ + + + L + A+ A + +L K
Sbjct: 3656 TLEQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEA 3712
Query: 1953 REIESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 2008
+ ++ ++ A + V RE ++ ED V T ++ + A+L
Sbjct: 3713 KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAIL 3771
Query: 2009 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 2068
+Q A D + K+ SL +I+ Q+S ++ + + L+ ++ +
Sbjct: 3772 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3831
Query: 2069 -----KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ------- 2114
K+ A S+ + Q +K++K+ K+ + E++ + + NQ
Sbjct: 3832 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 3891
Query: 2115 ---WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2169
WLTE + + + P E + + ++L++ I + + + +N TG ++++ S
Sbjct: 3892 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 3951
Query: 2170 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADN 2228
SI QEK + + + ++ + + R L+E + ++F +++ + LE +
Sbjct: 3952 PGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4010
Query: 2229 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDK 2286
+ P + +++KE++ + K + ++ Q + + L + G ++ + + ++
Sbjct: 4011 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4070
Query: 2287 LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIR 2344
+++KL Q W + + E+ EA++ D+ +L +K +H L++ + +
Sbjct: 4071 VQDKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQ 4121
Query: 2345 NQLEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVK 2396
+ + P + Q+ E A + Q +++ +++ G L +P VK
Sbjct: 4122 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4181
Query: 2397 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE 2456
+ +++L+S W ++N+ ++ I KLE
Sbjct: 4182 KSIDELNSAWDSLNKAWKD-----------------------------------RIDKLE 4206
Query: 2457 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2516
+ A + + DW+ + + S + DLE + + I + K +
Sbjct: 4207 EA------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4260
Query: 2517 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2576
Q++ ++E L A+ L K + + + + D + ++ WD ++E + NR+ +L L
Sbjct: 4261 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4320
Query: 2577 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2636
Q+ A +E L L K AI+ ++ + L D+ Q+ V+
Sbjct: 4321 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4380
Query: 2637 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2696
N L+ + ++ + E +N W+++ ++ +R+ L+ R + F ++E
Sbjct: 4381 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4440
Query: 2697 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2756
WLT+ E + + L + KE + ++ EA + Y +L + Q
Sbjct: 4441 LQQWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQ 4494
Query: 2757 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2816
++L S + + + ++N+ KW + K ++ LE + + H SLQ+ + W
Sbjct: 4495 QMLARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4553
Query: 2817 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQP 2873
L + L+ + V Q D H+ F E+ + I+ +T ++ F +Q
Sbjct: 4554 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4613
Query: 2874 LEGLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQR 2923
+ ++ L + + R + V + L RK+A++ + W KL +W
Sbjct: 4614 VVLIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLE 4664
Query: 2924 KIDETLERLQELQEATDELDLKLRQ 2948
+ +++L+ E+ D++ +L Q
Sbjct: 4665 ESEKSLDSELEIANDPDKIKTQLAQ 4689
Score = 226 bits (576), Expect = 3e-58
Identities = 345/1758 (19%), Positives = 713/1758 (40%), Gaps = 172/1758 (9%)
Query: 328 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 387
+ L E+ ++ R+Q ALE +LSW++ E+ + Q S + +VVK Q + L
Sbjct: 3328 AQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD 3387
Query: 388 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 447
+ V I + G K+ T + + ++ ++ +Q++LL+SRWE L + + L + +
Sbjct: 3388 RKSTVEVIKREGEKIATTAEPA--DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3445
Query: 448 LQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 505
Q ++ L+ LN+WLT E+R + EP+G L+ Q+ QHK L++D+ + N
Sbjct: 3446 AQQFHETLEPLNEWLTTIEKRL--VNCEPIGTQASKLEEQIAQHKALEDDI----INHNK 3499
Query: 506 LTHMVVVVDES----SGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 561
H V + +S S ++ +L + I + R LLQ L +
Sbjct: 3500 HLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFG 3559
Query: 562 EEQCLFSAWLSEKEDAVNKI-----HTTGFKDQNEMLSSLQKLAVLKAD---------LE 607
E++ WL+E D ++K+ T G Q L LQ+ +L+ LE
Sbjct: 3560 EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLE 3619
Query: 608 KKKQSMGKLYSLKQDLLSTLKNK--------------------------SVTQKTEAWLD 641
KQ+ G + QD L +K + S ++ WLD
Sbjct: 3620 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3679
Query: 642 NF---ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK-HAQE 697
++ V K E+++ + + + +++++ V++ LV A+E
Sbjct: 3680 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRARE 3739
Query: 698 ELPP--PPPQKKRQITVDSEIRKRLDVDITELH------------SWITRSEAVLQSPEF 743
L ++ ++ D+ +K ++D L SWIT +E L S
Sbjct: 3740 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3799
Query: 744 AIFRKEGNFSDLK-EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE 802
++ + L+ +K +E + + + D +S ++ E S+K+ +
Sbjct: 3800 IRLEQDQTSAQLQVQKTFTMEILRHKDI--IDDLVKSGHKIMTACSEE--EKQSMKKKLD 3855
Query: 803 QLNSRWIEFCQLLSERLNWLEYQNNII-AFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 861
++ + CQ+ SER LE +++ F+ ++L T ++ + P E
Sbjct: 3856 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3915
Query: 862 IKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMF-LDADFVAFTNHFKQVFSD 920
++ Q + + ++ +P I+++ L E G F + +VA + Q+ D
Sbjct: 3916 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3975
Query: 921 VQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQA 980
V+ R L ++ + + I +++ +L P + E +++++ E +
Sbjct: 3976 VKKRAVALDEAIS--QSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4033
Query: 981 LQSSLQEQQSGLYYLSTTVKEM---SKKAPSEISRK-YQSEFEEIEGRWKKLSSQLVEHC 1036
+ +++ Q L +EM S +IS K Q + +++ W+ + + + E
Sbjct: 4034 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4093
Query: 1037 QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKE-EWPALGDSEILKKQLKQCRLLVSDIQ 1095
KL + M K +L + + F+++ E P + D ++K+Q + + +I
Sbjct: 4094 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI-DPSVVKQQQEAAETIREEID 4152
Query: 1096 TIQPSLNSV-NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1154
+Q L+ V N G + I EP+ ++ + ELN+ WD + + R + L+ ++
Sbjct: 4153 GLQEELDIVINLGSELIAACGEPD-KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4211
Query: 1155 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1214
V Q L + +W+ A + + +++ +EE+K+ K EA Q++ +++ L
Sbjct: 4212 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4271
Query: 1215 ESVNSVIAQAPPVA-QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEK 1273
++ + + + ++ L L + L R+ + LE + L++
Sbjct: 4272 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4331
Query: 1274 ANKWLNEVEFKLKTTENIPGGAEEISEVLDS---LENLMRHSEDNPNQIRILAQTLTDGG 1330
WL E L + + G + I L L+N + + + L +
Sbjct: 4332 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4391
Query: 1331 VMDELIN--EELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1388
+E N +LE N RW+ + E+ +R++ L+ +++ A+ + +Q+ LT ++
Sbjct: 4392 AGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERH 4451
Query: 1389 LAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEE-----MKKHNQ-----GKEAAQR 1435
L A +P+ A++ + ++ + + EE M+K Q K A
Sbjct: 4452 LLA----SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4507
Query: 1436 VLSQIDVAQKKLQDVSMKF--------RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1487
+ I+ ++K + V K F LQ+ L + + L
Sbjct: 4508 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4567
Query: 1488 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLH 1547
S+ + V Q++ ++ + ++ + KTG + Q ++ + + +++
Sbjct: 4568 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4627
Query: 1548 YNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEV 1607
+ ++ ++ ER + L+ K +++ + + L EWL ++ L + P + +++
Sbjct: 4628 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4687
Query: 1608 AWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1665
A K QK + + + G +L KT L ++D LS L W + ++ E
Sbjct: 4688 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4747
Query: 1666 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK-----KKPQQKEDVLKRLKAEL 1720
N L E F + + W+ + + L E + D K + EL
Sbjct: 4748 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4807
Query: 1721 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS--HRIKTGKASIPLKE 1778
V + + A L+ D V+ Q+ EL+ R+ + K + L++
Sbjct: 4808 GKRTSSVQALKRSARELIEGSRDD-SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4866
Query: 1779 LEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1833
E+F+S + LLE L AE +Q GV +ED + + + ++ +K+L ++ L +
Sbjct: 4867 AEEFHSVVHALLEWL-AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKA 4925
Query: 1834 IT------------------------DERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1869
T R E + +Q Q +AL L + +++ L
Sbjct: 4926 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIA--KQELL 4983
Query: 1870 EISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1929
E W Q+ L D +K++ P++ ++K + E Q EE+ +
Sbjct: 4984 EALLAWLQWAETT------LTDKDKEVI----PQEIEEVKALIAEHQTFMEEMTRKQPDV 5033
Query: 1930 EGLSEDGAAMAVEPTQIQ 1947
+ +++ A +P+ +Q
Sbjct: 5034 DKVTKTYKRRAADPSSLQ 5051
Score = 221 bits (564), Expect = 8e-57
Identities = 112/232 (48%), Positives = 154/232 (66%), Gaps = 5/232 (2%)
Query: 6 SDEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGST 65
+DER+ VQKKTFTKW+N K K H+ +L+ DL+DG L+ LLE L+G LP+EKG
Sbjct: 59 ADERDKVQKKTFTKWINQHLMKVRK-HVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRM 117
Query: 66 RVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMA 125
R H L NV AL L+ V LVNI + DI DGN KLTLGLIW IILH+Q+ ++ ++
Sbjct: 118 RFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDI--HVTG 175
Query: 126 GLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQ 185
+ ++++ LL W +Q+T Y + NFTT W DG NA+IH +RPDL D N+V
Sbjct: 176 ESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV- 234
Query: 186 QSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 237
QS LEHAF +A ++G+ +LLDPEDVD + PD+KS++ Y++SL+ P+
Sbjct: 235 QSNLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK 285
Score = 205 bits (521), Expect = 8e-52
Identities = 284/1564 (18%), Positives = 642/1564 (41%), Gaps = 148/1564 (9%)
Query: 264 LHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA-YTQAAYVTTSDPTRSPFPSQHLEAPE 322
++H H Q +++ + + K +S ++Q Y+ + + S
Sbjct: 3495 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCN 3554
Query: 323 DKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYM 382
K FG E EV L + + + LS L + + + + +++ V+++
Sbjct: 3555 AKIFG----EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE--------- 3601
Query: 383 MDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH 442
D+ + V L G +L+ + + DE +Q+++ + +R++ + S + L
Sbjct: 3602 -DILLRKQNVDQALLNGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLE 3658
Query: 443 RVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQ 500
+ L + + +EL WL K E E + L E+ + + K L+++ + +
Sbjct: 3659 QALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG--EEASQAQMRPKELKKEAKNNK 3716
Query: 501 VRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRL 560
++SL + + E A LE+ + +R+ + + + +L+ Q+
Sbjct: 3717 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3776
Query: 561 TEEQCLFSAWLSEKEDA-------------------VNKIHTTGFKDQNEMLSSLQKLA- 600
+ +W++E E V K T +++ L K
Sbjct: 3777 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3836
Query: 601 -VLKADLEKKKQSMGKLYS--LKQ-DLLSTLKNKSVTQ--KTEAWLDNFARCWDNLVQKL 654
++ A E++KQSM K LK D + + ++ Q + ++ ++ F ++ L L
Sbjct: 3837 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 3896
Query: 655 EKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ--EELPPPPPQ------- 705
++ + ISQ P+L T+ + +++ +H +++ PQ
Sbjct: 3897 TETQSIISQLPA---PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3953
Query: 706 -----KKRQITVDS-------EIRKR---LDVDITELHSWITRSEAVLQSPEFAIFRKE- 749
+++ + D+ +++KR LD I++ + + + +L+S E + R
Sbjct: 3954 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4013
Query: 750 -----GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMV------NEGVNADSIK 798
+KE+++ + + KLQ + + E+M+ ++ ++A +++
Sbjct: 4014 PPSISAEVEKIKEQISENKNVSVD-MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4072
Query: 799 QASEQLNSRWIEFCQLLSER-LNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 857
+Q+ W L+ ER L+ F+ L +++++
Sbjct: 4073 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4132
Query: 858 EPTAIKSQLKICKDEVNRLSGLQPQIE---RLKIQSIALKEKGQGPMF---LDADFVAFT 911
+P+ +K Q + + + GLQ +++ L + IA + P+ +D A+
Sbjct: 4133 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4192
Query: 912 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 971
+ K + E+ +Q ++YQ+ + A+ WV + KL+ TD E +
Sbjct: 4193 SLNKAWKDRIDKLEEAMQAA------VQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 4246
Query: 972 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEFEEIEGRWKKLSS 1030
+Q++ EL+ +S +QQ + L+ + + KK E + Q E++ W L
Sbjct: 4247 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 4306
Query: 1031 QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 1090
+++ KLE + L + Q+ + L W+ + L E+ P GD + ++ +L + +L
Sbjct: 4307 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4366
Query: 1091 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1150
+D+ Q ++ +VN+ G + + E AS L+ +L+ LN +W ++ ++ RK+ L G
Sbjct: 4367 QNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDG 4426
Query: 1151 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKV 1210
L + ++ ++ +W+T E L P+ ++ + + KE
Sbjct: 4427 ALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4486
Query: 1211 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1270
K L + ++A+ P A+ + +++ L ++ + T+LN + LEE E +
Sbjct: 4487 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4546
Query: 1271 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1330
L+ WL + E L + + +D + + QI L +T T
Sbjct: 4547 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4606
Query: 1331 VMDE-----LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI 1385
+ LI L + SRW ++ + V R + L+ + + A++ ++ + E L
Sbjct: 4607 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4666
Query: 1386 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQK 1445
+K L + + ++ + KI++ L H +E +K K + ++ + K
Sbjct: 4667 EKSLDSEL-------EIANDPDKIKTQLAQH----KEFQKSLGAKHSVYDTTNRTGRSLK 4715
Query: 1446 ----------KLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPAL------ 1484
KL D+ + R + K + +L+E+ + + L AL
Sbjct: 4716 EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYR 4775
Query: 1485 -ETKSVEQEVVQSQLNHCVNL-------YKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1536
E + E + V ++ +NL K L + S V+ + ++ R++++ + ++
Sbjct: 4776 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR-DDSSW 4834
Query: 1537 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1596
+ ++ L + + A ++ +LE L+ + + ++ L EWLA + L +
Sbjct: 4835 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4894
Query: 1597 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDKLSLLNSN 1655
L + + K K++E+++ L T +G+ + + T ++ ++++ +
Sbjct: 4895 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4954
Query: 1656 WIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR 1715
+ V + A++ L + + ++ + W+ A+T L + +K+ Q+ + +K
Sbjct: 4955 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5014
Query: 1716 LKAE 1719
L AE
Sbjct: 5015 LIAE 5018
Score = 178 bits (452), Expect = 8e-44
Identities = 527/2759 (19%), Positives = 1063/2759 (38%), Gaps = 415/2759 (15%)
Query: 452 KLKELNDWLTKTEE--------RTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 503
KLK +N L T+ T+ EEE + D +++ + K + ++++++
Sbjct: 1199 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 1258
Query: 504 NSLTHMV----VVVDESSGDHATAALE-----EQLKVLGDRWANICRWTEDRWVLLQDI- 553
++L + + DE + L+ E+ L +RW N+ ++R L+ I
Sbjct: 1259 HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 1318
Query: 554 -LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQS 612
LK+ R T W+ + E KI ++ + + L + +L +++E K+
Sbjct: 1319 KSLKYYRDTYHP--LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1376
Query: 613 MGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 672
M + + +T+K+ + T + D+ + K S A Q +
Sbjct: 1377 MDECQKYAEQYSATVKDYELQTMT------YRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1430
Query: 673 TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWIT 732
T + T+ T+ +K A + L ++K +++ E ++ ++ EL W++
Sbjct: 1431 DLRTRYTALVTLMTQ---YIKFAGDSLKRLEEEEK---SLEEEKKEHVE-KAKELQKWVS 1483
Query: 733 RSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV 792
L+ E K G K+K+++ E + K +L +A ++ Q + + +
Sbjct: 1484 NISKTLKDAE-----KAGKPPFSKQKISS--EEISTKKEQLSEALQTIQLFLAKHGD--- 1533
Query: 793 NADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ 852
K E+ N L +++ L+ N++ F L+QL++ T+ + +K+
Sbjct: 1534 -----KMTDEERNE--------LEKQVKTLQESYNLL-FSESLKQLQESQTSGD--VKV- 1576
Query: 853 PTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN 912
E + + + K+++ + L Q E I G F+ D
Sbjct: 1577 -----EEKIVAERQQEYKEKLQGICDLLTQTENRLI--------GHQEAFMIGDGTVELK 1623
Query: 913 HFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET--KLSIPQLSVTDYEI 970
+ Q++++ELQ Q + A+ V+ +E K + +LS D +
Sbjct: 1624 KY-------QSKQEELQKDM--------QGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1668
Query: 971 MEQRLGE--LQALQSSLQEQQSGLYY---LSTTVKEMSKKAPS-----EISRKYQSEFEE 1020
+EQ+L E ++ Q +L+ +QS ++T +KE ++K + E K ++ +
Sbjct: 1669 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1728
Query: 1021 IEGRWKKLSSQLVEHCQKLEE-----QMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 1075
+ K +H Q +E+ Q + + + E DV +
Sbjct: 1729 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1788
Query: 1076 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD 1135
++ +K Q ++S Q + + S +K PE +L+ +KEL ++
Sbjct: 1789 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYE 1848
Query: 1136 HMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEE 1195
+ + + E+ D +E W+ Q+E+E + + L ++
Sbjct: 1849 TALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR 1908
Query: 1196 MKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ------------EALKKELETLTTNY 1243
K E+ + ++ +T S N V+ A ++ ++++L+ T +
Sbjct: 1909 QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRF 1968
Query: 1244 QWL---CTRLNGKCKTLEEVWACWHE----LLSYLE----KANKWLNE--------VEFK 1284
+ L C L K L + + + + LL+ L+ A+K L+E ++ +
Sbjct: 1969 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 2028
Query: 1285 LKTTENIPG----------------------------GAEEISEVLDSL----ENLMRHS 1312
L+ T+ + G +I + LD + E+L +
Sbjct: 2029 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSV 2088
Query: 1313 EDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEA------------VRRQKL 1360
+ +++I TLT + + ++E L+ + L E+ + + +
Sbjct: 2089 NERNEKLQI---TLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIM 2145
Query: 1361 LEQSIQSAQETEKSLH-LIQESLTFIDKQLAAYIADKVD--AAQMPQEAQKIQSDL---- 1413
LEQ I Q + +++ +++ + D A+ + K+ +A+ + + K + L
Sbjct: 2146 LEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKME 2205
Query: 1414 ---TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 1470
T E+ +K E + L+++DV K + ++S Q +QES
Sbjct: 2206 ELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELS-------------QYMQES 2252
Query: 1471 KMILDEVKMHLPALET--KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK 1528
E K HL L + K + + S + +LS+ E+E IK ++ V
Sbjct: 2253 TSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTS 2312
Query: 1529 KQTENP-------------KELDERVTALKLHY--NELGAKVTERKQQLEKCLKLSRKMR 1573
Q + KE ++V ++ + +LG + + K+ EK + +++
Sbjct: 2313 CQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ 2372
Query: 1574 KEMN---VLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEV 1630
K N L ++A +AV+ + L+ E G AT E L SI +
Sbjct: 2373 KVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE---GTATNTEEFWANKGLTSIKKD 2429
Query: 1631 GEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 1690
+ L++DK++ LN+ + EE ++ QK +T TKW
Sbjct: 2430 MTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT-------ATKW 2482
Query: 1691 IIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLM--------ANRG 1742
Q ++E K Q +++ K +AEL KV +D+ L+ A R
Sbjct: 2483 --QQTPAPTDTEAVKTQVEQN--KSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRW 2538
Query: 1743 DHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVN 1802
++ + ELN I + K ++S L + + + +++ L +E E+ V
Sbjct: 2539 KQMLTEIDSKWQELNQ--LTIDRQQKLEESSNNLTQFQTVEAQLKQWL--VEKELMVSV- 2593
Query: 1803 LKEEDFNKDMNEDNEGTVKELLQR--------------GDNLQQRITDERKREEIKIKQQ 1848
L + +M V+ LLQ G + R ++ I +K+Q
Sbjct: 2594 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGI-VKEQ 2652
Query: 1849 L--LQTKHNALKDLRSQR---RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1903
L + K ++L S R +A+ S Q+ R D L LD+ K +SL
Sbjct: 2653 LAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN--KLSSSLAVST 2710
Query: 1904 DERKIKEIDRELQKKKEELNAVRRQ---AEGLSEDGAAMAVEP-TQIQLSKRWREIESKF 1959
+ + QK K+E+ ++Q A+ L ED +A+ E + +LS R++E
Sbjct: 2711 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELS---RQLEGIL 2767
Query: 1960 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV---EQLLNA 2016
F+ + + V+ L+ + S +++ QA L+ EQ +
Sbjct: 2768 KSFKDVEQKAENHVQH-----------LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2816
Query: 2017 PDLCAKD-FEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALS 2075
P D E L K K+ +L S + ++ L E+ LQ L+
Sbjct: 2817 PISAKLDVLESLIKDH---KDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLN 2873
Query: 2076 QLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQI---PENW 2132
+ W+ NK K+R+ + S+EK ++ ++ W+ + + L + + P
Sbjct: 2874 TIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG 2933
Query: 2133 EHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC 2192
E++ K LK LQ + Q +V LN T ++ + D ++ ++ SL + V
Sbjct: 2934 ENSIAK--LKSLQKEMDQHFGMVELLNNTANSLL-SVCEIDKEVVTDENKSLIQKVDMVT 2990
Query: 2193 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-------DNIAS----------IPLE 2235
+QL +K LE EFQ E L+ A D++ S + +
Sbjct: 2991 EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3050
Query: 2236 PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLK--- 2292
Q LK +++ K L ++L + K ++ VL+ +E L ++
Sbjct: 3051 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSD----VLLQVETIAQEHSTLSQQVDEKC 3106
Query: 2293 ---QTNLQWI----KVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRN 2345
+T LQ I R + + E + ++ + + + E L++Q + +L +
Sbjct: 3107 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEA 3166
Query: 2346 QLEIYNQPNQEGPFDVQETEIA-----------------------VQAKQPDVEEILSKG 2382
+ + N+ + E + QA++ VE + +
Sbjct: 3167 LMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRL 3226
Query: 2383 QHLYKEKPATQPVKRKLED-------LSSEWKAVNRLL-----------QELRAKQPD-- 2422
+ Y + + +K E+ + E + +N+ L + L+ KQ D
Sbjct: 3227 EEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVN 3286
Query: 2423 -LAPGLTTIGASPTQTVTLV--TQPVVTKETAISKLEMPSSLMLEVPAL--ADFNRAWTE 2477
L GL A T T L V + ++K + L+ L F A
Sbjct: 3287 WLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALES 3346
Query: 2478 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 2537
L W+ ++++ +Q+ + + + I +QK + L+ R+ +E + + + T
Sbjct: 3347 LLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAT-T 3405
Query: 2538 SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 2597
+ + I ++ + ++W+ + + R +QL + + Q+ E E + L
Sbjct: 3406 AEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEK 3465
Query: 2598 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHM 2657
+L + + ++++I + K L D+ ++ A + L S +D V
Sbjct: 3466 RLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQS 3525
Query: 2658 ITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRK 2717
+ + I ++ R L++ + F D + + WL E +
Sbjct: 3526 KLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH---------DKL 3576
Query: 2718 ERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDE---NSQKILRSLEGSDDAVLLQRR 2774
+L + L KQ +L+ E N+D+ N ++L+ G D+ +++Q +
Sbjct: 3577 SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTG-DEVLIIQDK 3635
Query: 2775 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDE-LSRQAPIGGD 2833
L+ + ++ ++ K S ++ LE + +RLH + +EL WL + E LS + +
Sbjct: 3636 LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG 3695
Query: 2834 FPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQP---LEGLEKLYQEPRELPPE 2890
A Q Q + K+E K + ++ S E L P EGLEK+ E
Sbjct: 3696 EEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAE-----DN 3749
Query: 2891 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-DLKLRQ 2948
ER + V+ + ++ EE+ + L S + + D L + E ++ L D++L Q
Sbjct: 3750 ERYRLVSDTITQKVEEI----DAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3804
Score = 38.9 bits (89), Expect = 0.095
Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 27/168 (16%)
Query: 2810 LQELLVWLQLKDDELSRQAPIGGDFPAVQKQ----NDVHRAFKR-ELKTKEPVIMSTLET 2864
+Q+LL W+ +L R G D P+V+ +VHRA + E KE I T
Sbjct: 637 VQDLLNWVDEMQVQLDR-TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 695
Query: 2865 VRIFLT-EQPLEGLEKLY--------QEPRELPP----EERAQN-VTRLLRKQAEEVNTE 2910
+ LT + L LE Y + R L RA N + L K+ EEV +
Sbjct: 696 APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYD 755
Query: 2911 WEKLNL-------HSADWQRKIDETLERLQELQEATDELDLKLRQAEV 2951
W + N + A+ R++D+ E ++ +QE ++L L+ A +
Sbjct: 756 WSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 803
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 325 bits (832), Expect = 7e-88
Identities = 545/2835 (19%), Positives = 1126/2835 (39%), Gaps = 316/2835 (11%)
Query: 338 DRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQ 397
++ QT LE L + + E+S ++ +F H+ ++ +L
Sbjct: 2230 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-----------EVLH 2278
Query: 398 LGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKE 455
K I + L D+ V E+ N L+ +++ + EK+ + + +D +K
Sbjct: 2279 SLLKEISSHGLPSDKAL-VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2337
Query: 456 LNDWLTKTEERTRKMEE----EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 511
L W+ +T ++ ++ E LG LED K+ ++ + ++++ SL +++
Sbjct: 2338 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2397
Query: 512 VVDESSGDHATAALEEQLKVLGDR---------WAN------------ICRWTEDRWVLL 550
V + A AA++ VL WAN I ED +LL
Sbjct: 2398 AVTTPA--KAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2455
Query: 551 QDI-------LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS-LQKLAVL 602
+D L K Q+ EE WL + K T E + + +++
Sbjct: 2456 KDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSF 2515
Query: 603 KADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS 662
+A+L KQ++ K+ LK L L+ T + W D+ Q+L + T
Sbjct: 2516 EAEL---KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEI-DSKWQELNQLTIDRQ 2571
Query: 663 QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV 722
Q + + +LTQ +E
Sbjct: 2572 QKLEESSNNLTQFQTVEA------------------------------------------ 2589
Query: 723 DITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 782
+L W+ E ++ S + + +++V + +E A + + + + + Q
Sbjct: 2590 ---QLKQWLVEKELMV-SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2645
Query: 783 LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQN-NIIAFYNQLQQLEQM 841
++ + + +K+ + +W LS+R +W++ + + L+ L
Sbjct: 2646 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2705
Query: 842 TTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQ----SIALKEKG 897
+ +N L + P A+ QL+ + + + QI+ + S +KE+
Sbjct: 2706 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE- 2764
Query: 898 QGPMFLDADFVAFTNHFKQVFSDVQAR-EKELQTIFDTLPPM-RYQETMSAIRTWVQQSE 955
+L A+ + F DV+ + E +Q + ++Q+ + W+ +
Sbjct: 2765 ----YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2820
Query: 956 TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 1015
+ + +++E + + + +L Q + + K Q
Sbjct: 2821 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2880
Query: 1016 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW---- 1071
+ I+ W + Q+ E KL+E + K K + ++TL W+ + L+E
Sbjct: 2881 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2940
Query: 1072 PALGDSEI-----LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE 1126
PA G++ I L+K++ Q +V + SL SV E +++ + E
Sbjct: 2941 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-----------E 2989
Query: 1127 LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD------ 1180
K L + D + +Q++++K L+ +K Q+ E + A+E+ D
Sbjct: 2990 NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA 3049
Query: 1181 FEYKTPDELQKAVEEMKRAKEEAQ-QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETL 1239
+ K LQ + ++ K + K L+ E+ +S + E + +E TL
Sbjct: 3050 YSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL 3109
Query: 1240 TTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEIS 1299
+ C+ L K + + E+ S + + L+ + + E + E I
Sbjct: 3110 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIK 3169
Query: 1300 EVLDSLENLMRHSEDNPNQI--RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRR 1357
L LE LM S DN N+ +LA T ++ I +LE + + +L + A R
Sbjct: 3170 AFLKKLEALMA-SNDNANKTCKMMLATEETSPDLVG--IKRDLEALSKQCNKLLDRAQAR 3226
Query: 1358 QKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMP--QEAQKIQSDLTS 1415
++ +E +I+ +E L +E + K A++ + +Q P E + I L
Sbjct: 3227 EEQVEGTIKRLEEFYSKL---KEFSILLQK------AEEHEESQGPVGMETETINQQLNM 3277
Query: 1416 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 1463
++ +E + QGK+ L Q I A K L DV+ +++ L +K A
Sbjct: 3278 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3337
Query: 1464 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 1509
+LQE+ + + L +L + S E +VV++Q+ L + L
Sbjct: 3338 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3397
Query: 1510 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 1569
+ KS VE++ + G +I + + ++ ++++ L + L K R +QLE ++
Sbjct: 3398 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3457
Query: 1570 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 1629
++ + + L EWL + L + S L+ ++A KA + +I HL
Sbjct: 3458 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3517
Query: 1630 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1688
+G++LK + +++ +V+ KL +I + ++ LL + + + F ++ +
Sbjct: 3518 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3577
Query: 1689 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 1748
W+ + L S+ + L + ++EL ++ + + + N + ++
Sbjct: 3578 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3635
Query: 1749 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 1796
++ + + AI R K T ++ K LEQ ++L L+ +E E
Sbjct: 3636 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3695
Query: 1797 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 1846
+ + LK E+ + K++ ++ N + + L + + R RE ++
Sbjct: 3696 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3755
Query: 1847 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1906
++ + D +Q+ ++ + Q+ + AD L + + EKKL SL + R E+
Sbjct: 3756 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3815
Query: 1907 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1966
+ +LQ +K + R + + D + S+ ++ K N
Sbjct: 3816 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3871
Query: 1967 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 2026
+ I + E + + L ++ TY + L E + +++ A ++E
Sbjct: 3872 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 3926
Query: 2027 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2086
L +Q+E + +++ + + ID ++ K L +P E +QE D + ++ +
Sbjct: 3927 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3985
Query: 2087 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 2144
K R D ++ + +FH I +Q L E+ + + + P + E K K + E
Sbjct: 3986 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 4042
Query: 2145 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 2197
++ + + Q + TL GEE+I +S TD I +Q+KL + W+ + + +
Sbjct: 4043 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4102
Query: 2198 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 2256
R+ +L + + +F D ++ +++ + +PG + + K++ E + + EE+
Sbjct: 4103 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4162
Query: 2257 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 2314
Q L + G ++ + E DK ++ + + N W +++A ++ ++E
Sbjct: 4163 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 4218
Query: 2315 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2371
++ Q + L+ D + L +SPI LE Q +E +++ + +
Sbjct: 4219 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 4274
Query: 2372 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 2431
Q ++E + + + L K K + K ++D E K + L+E
Sbjct: 4275 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 4318
Query: 2432 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 2491
++ ++ KLE +L+ AL F A EL WL+ + ++
Sbjct: 4319 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 4356
Query: 2492 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2551
Q+ + GD + I + K D+ + +E + A +L ++ +EA + +++E
Sbjct: 4357 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4415
Query: 2552 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2611
+ +W V E + R+QQL+ L+ + + E+ +Q L L + K +
Sbjct: 4416 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4475
Query: 2612 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2671
++++ ++ + ++L + N+ W S+
Sbjct: 4476 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4535
Query: 2672 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 2731
+++ER+ LEE L +F L+ F+ WLT+AE T NV A+R +L+ V +
Sbjct: 4536 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4589
Query: 2732 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 2791
+ + E+ +H + LD+ L+ D VL++ L ++ +W ++ ++ +
Sbjct: 4590 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4648
Query: 2792 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 2851
L+ + + K+ H + +L+ WL+ + L + I D ++ Q H+ F++ L
Sbjct: 4649 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4708
Query: 2852 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 2911
K V +T T R L + + L E+ +W
Sbjct: 4709 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4749
Query: 2912 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 2970
+ + S + Q K++E L + +A L L + E QPV GD ID + +
Sbjct: 4750 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4807
Query: 2971 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 3023
++ KA + E+ +V + AR+L S + +++L+TRW+ +
Sbjct: 4808 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4867
Query: 3024 QVAVEDRVRQLHEAH 3038
Q +E +RQ E H
Sbjct: 4868 QTRLEAALRQAEEFH 4882
Score = 325 bits (832), Expect = 7e-88
Identities = 536/2814 (19%), Positives = 1113/2814 (39%), Gaps = 346/2814 (12%)
Query: 330 LMESEVNLDRYQTALEE---VLSWL--LSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD 384
+ E L + Q A EE ++ WL ++ T Q D E VK Q ++ + +
Sbjct: 2459 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2518
Query: 385 LTAHQGRVGNILQLGSKLIGTGKLSEDEETEV----QEQMNLLNSRWECLRVASMEKQSN 440
L + V + +L KL T L E+ +T ++ + ++S+W+ L ++++Q
Sbjct: 2519 LKQN---VNKVQELKDKL--TELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2573
Query: 441 LHRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQ 498
L +L + E L WL + E + PL D L Q QQ ++L ++
Sbjct: 2574 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLG--PLSIDPNMLNTQRQQVQILLQEFAT 2631
Query: 499 EQVRVNSLTHMVVVVDESSGDHAT--AALEEQLKVLGDRWANICRWTEDRWVLLQDILLK 556
+ + LT + G+ + ++EQL + +W ++ DR + ++K
Sbjct: 2632 RKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVK 2691
Query: 557 WQRLTEEQCLFSAWLSEKEDAVNKIHT-----TGFKDQNEMLSSLQKLAVLKADLEKKKQ 611
T+ Q L + + D NK+ + T N+ L + QK+ K +++++K+
Sbjct: 2692 ---STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKM---KQEIQQEKK 2745
Query: 612 SMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ-- 669
+ +L +DL + +K + + + L+ + + ++ QK E + A ++
Sbjct: 2746 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2805
Query: 670 ----------------------PSLTQTTVMETVT-------------------TVTTRE 688
P + V+E++ T+ E
Sbjct: 2806 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2865
Query: 689 QILVKHAQEELPPPPPQ---------------KKRQITVDSEIRKRLDV--DITELHSWI 731
+L+K E Q K+R+ + + K L + L WI
Sbjct: 2866 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 2925
Query: 732 TRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV------- 784
+ + L+ +F + EG S K K ++++E + F ++ + +A +L+
Sbjct: 2926 DKCQNNLEEIKFCLDPAEGENSIAKLK--SLQKEMDQHFGMVELLNNTANSLLSVCEIDK 2983
Query: 785 EQMVNEGVNA-DSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 843
E + +E + + +EQL+S+ +FC L + + E+Q QLQ ++
Sbjct: 2984 EVVTDENKSLIQKVDMVTEQLHSK--KFC-LENMTQKFKEFQEVSKESKRQLQCAKEQLD 3040
Query: 844 TAEN---------WLKIQPTTPSEPTAIKSQLKICKDEVNRL----------SGLQPQIE 884
++ +L + T A+K Q+ + K L S + Q+E
Sbjct: 3041 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE 3100
Query: 885 RLKIQSIALKEK-GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPM-RYQE 942
+ + L ++ + FL+ HF+ ++ ++ E D++ P+ R E
Sbjct: 3101 TIAQEHSTLSQQVDEKCSFLETKLQGI-GHFQNTIREMFSQFAEFDDELDSMAPVGRDAE 3159
Query: 943 TMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEM 1002
T+ + ++ KL S + + + +E L + ++ +
Sbjct: 3160 TLQKQKETIKAFLKKLEALMAS-------NDNANKTCKMMLATEETSPDLVGIKRDLEAL 3212
Query: 1003 SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1062
SK+ + R Q+ E++EG K+L E KL+E L+K + H ++
Sbjct: 3213 SKQCNKLLDRA-QAREEQVEGTIKRLE----EFYSKLKEFSILLQKAEEHEES------- 3260
Query: 1063 VDVFLKEEWPALGDSEILKKQLKQCRLLVSD-IQTIQPSLNSVNEGGQK-IKNEAEPEFA 1120
+ P ++E + +QL ++ + I+ +Q VN GQ I++ A+
Sbjct: 3261 -------QGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTST 3313
Query: 1121 SRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD 1180
LE +L ++N +W + ++V R L+ L Q L + WM EE +
Sbjct: 3314 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3373
Query: 1181 FEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLT 1240
++ ++E K + +++ V+++ + A P + + K+L L
Sbjct: 3374 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3433
Query: 1241 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1300
+ ++ L + + + LE + + LE N+WL +E +L E I A ++ E
Sbjct: 3434 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3493
Query: 1301 VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELET-------FNSRWR-ELHE 1352
+ + L +D N + L Q ++ G + L + E + F+ W E+ E
Sbjct: 3494 QIAQHKAL---EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3550
Query: 1353 EAVRRQKLLEQSIQSAQET-EKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK--I 1409
++ R +LL+Q++ +A+ E + L+ DK + D Q+++ +
Sbjct: 3551 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3610
Query: 1410 QSDLTSHEISLEEMKKHNQGKEAAQRVLS-QIDVAQKKLQDVSMKFRLFQKPAN-----F 1463
Q D+ + ++++ + G E ++ ++ + Q KL+ + +++ K +
Sbjct: 3611 QEDILLRKQNVDQALLN--GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3668
Query: 1464 EQRLQESKMI----------LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1513
EQ LQ ++ + LD+V++ L + ET+ ++ E L K K+
Sbjct: 3669 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKA 3728
Query: 1514 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1573
++ + + +++ + L++ V Y + +T++ ++++ + S++
Sbjct: 3729 LLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFD 3788
Query: 1574 KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEA 1633
+ + W+ T+ +L + +++ K EI + K + + + G
Sbjct: 3789 QAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHK 3848
Query: 1634 LKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWII 1692
+ T ++E ++ KL + N+ + E L Q + F + + + W+
Sbjct: 3849 IMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT 3908
Query: 1693 QADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRGDH 1744
+ +++ E E + QQ+E L+ L AE K++ T Q L G
Sbjct: 3909 ETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS 3968
Query: 1745 CRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ--- 1799
++ + + ++ I +K ++ + + QF+ I ++LE LE +++
Sbjct: 3969 ----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4024
Query: 1800 --GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIKQQ 1848
++ + E + ++E+ +V + L QRG+ + R K K Q
Sbjct: 4025 PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 4084
Query: 1849 LLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-D 1904
L + L +R K L++ ++ L+ + D + + L +P D
Sbjct: 4085 KLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4144
Query: 1905 ERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKFAQ 1961
+K+ + +EE++ ++ + + L + A EP + + K E+ S +
Sbjct: 4145 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDS 4204
Query: 1962 FRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCA 2021
+ +I + EE M + Y + V + L +
Sbjct: 4205 LNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSPIG 4251
Query: 2022 KDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLDFQ 2080
D E + +Q E LK K Q ++ ++ + L+ T ++ +Q+ L +L
Sbjct: 4252 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 4311
Query: 2081 WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 2140
W+ + + +RQ + + ++ +F + + WLT E L + Q P + +
Sbjct: 4312 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIEIE 4370
Query: 2141 LKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSD 2197
L + LQ+ + Q+ V +N G ++I+ S+ +AS LQ KL LN RWQ V ++
Sbjct: 4371 LAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQ 4430
Query: 2198 RKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLVEE 2255
RK++L+ F ++ + WL + + +AS PL G + KE+L +
Sbjct: 4431 RKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVCAA 4489
Query: 2256 LPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEIEA 2314
++ K L + G +L P S E D+ N LK+ +W V L E++ ++E
Sbjct: 4490 FEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKLEE 4546
Query: 2315 QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---AV 2368
+ + L+D + WL+ L + ++P+ F + E ++ V
Sbjct: 4547 ALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4599
Query: 2369 QAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDLAP 2425
+ + + E+ G HL + +K +K L + S W K V RL++ R
Sbjct: 4600 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR-------- 4651
Query: 2426 GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLL 2485
SL F+ AW++L +WL
Sbjct: 4652 ----------------------------------SLDDARKRAKQFHEAWSKLMEWLEES 4677
Query: 2486 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI 2545
++ + S+ + D + I + + K + L + + ++LK KTS +
Sbjct: 4678 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4737
Query: 2546 ITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEG 2605
+ D + ++++WD + R+ +L E L S Q+ +A + L + +L +
Sbjct: 4738 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4797
Query: 2606 PYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINAS 2665
+D + I K K+L + ++V A +L+ S DD+ V + + ++
Sbjct: 4798 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELSTR 4856
Query: 2666 WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERLLE 2722
W ++ ++ LE R ++F + L WL EAE T VL D R L
Sbjct: 4857 WETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLI 4916
Query: 2723 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 2782
D KE MK+ ++ + E+ T + + ++ D ++ + + ++
Sbjct: 4917 DQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRARF 4966
Query: 2783 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQKQ 2840
E+ + + L ++ L+ LL WLQ + L+ + I + V+
Sbjct: 4967 EEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKAL 5026
Query: 2841 NDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LYQE 2883
H+ F E+ K+P + +T + I + ++ G ++ LY
Sbjct: 5027 IAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPS 5086
Query: 2884 PRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2937
+ E + V L+ K W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 5087 GSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 5132
Score = 316 bits (809), Expect = 3e-85
Identities = 546/2809 (19%), Positives = 1127/2809 (40%), Gaps = 353/2809 (12%)
Query: 337 LDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 396
L+++ E WL +E L+ ++D+ + + + + D+ +H+G + I
Sbjct: 1879 LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT 1938
Query: 397 QLGSKLIGTGKLSEDEE----------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 446
G++++ K + EVQ +++ R+ L +NL ++
Sbjct: 1939 ISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVD 1998
Query: 447 DLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 504
Q+ + L L E K EP+ D ++L+RQ+++ K LQ + +QV V
Sbjct: 1999 KYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE 2058
Query: 505 SLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRWVLLQDILLKWQRLT 561
L V+ ++ G A + Q K L D R+ ++ + +R LQ L + +
Sbjct: 2059 KLKKTAEVLLDARGSLLPAKNDIQ-KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2117
Query: 562 EEQCLFSAWLSEKEDAVNK-----IHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 616
+ W+ E ++ + +++T +D + K +L+ D+ ++ S+ +
Sbjct: 2118 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQD------IISKNIMLEQDIAGRQSSINAM 2171
Query: 617 YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTT 676
+ + T + S +A + + + + K +++ A++ + T + L +
Sbjct: 2172 NEKVKKFMETT-DPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVE--LFENL 2228
Query: 677 VMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDS-----EIRKRLDVDITELHSWI 731
+ T + T+ Q L + ++P + Q +S E +K L+V LHS +
Sbjct: 2229 SEKLQTFLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHKKHLEV----LHSLL 2281
Query: 732 TR-SEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE 790
S L S + + K N S +KF++++D + +
Sbjct: 2282 KEISSHGLPSDKALVLEKTNNLS--------------KKFKEMEDTIKEKK--------- 2318
Query: 791 GVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK 850
+++ EQL++ F L+ +W++ + E + + E+ K
Sbjct: 2319 ----EAVTSCQEQLDA----FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2370
Query: 851 IQPT----TPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKG--------- 897
+Q TP S + +C + ++ ++ I +K L +G
Sbjct: 2371 LQEKWSLKTPEIQKVNNSGISLC-NLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2429
Query: 898 --QGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQ-S 954
+G + D ++ ++ + ++ + EL T L + QE SA+ W+Q+ +
Sbjct: 2430 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--QKAQEESSAMMQWLQKMN 2487
Query: 955 ETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISR 1012
+T Q TD E ++ ++ + ++ ++ L++ + + L + E+ ++ P + +
Sbjct: 2488 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2547
Query: 1013 KYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 1072
+++ EI+ +W++L+ ++ QKLEE N L + Q LK+W+ E ++ + P
Sbjct: 2548 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2607
Query: 1073 ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA--EPEFASRLETELKEL 1130
D +L Q +Q ++L+ + T +P + GQ I + +P ++ +L +
Sbjct: 2608 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2667
Query: 1131 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1190
+WD + Q+ R + + + K+ Q L + + ++ + + PD +
Sbjct: 2668 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN 2727
Query: 1191 KAVEEMKRAKEEAQQKEAKVKL---LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLC 1247
+ +E ++ K+E QQ++ ++K+ L E +++++ + A+ L ++LE + +++ +
Sbjct: 2728 QQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--LSRQLEGILKSFKDVE 2785
Query: 1248 TRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLEN 1307
+ + L+ A H+ WL+ T + + IS LD LE+
Sbjct: 2786 QKAENHVQHLQSACASSHQFQQMSRDFQAWLD-------TKKEEQNKSHPISAKLDVLES 2838
Query: 1308 LMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1367
L++ +D ++TLT M E E E + + + A++ Q
Sbjct: 2839 LIKDHKD-------FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--------- 2882
Query: 1368 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN 1427
L+ I+ + +KQ+ + K++ SLE+ K+
Sbjct: 2883 -------LNTIKTNWDTFNKQVK-------------ERENKLKE-------SLEKALKY- 2914
Query: 1428 QGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETK 1487
KE + + ID Q L+++ KF L PA E + + K + E+ H +E
Sbjct: 2915 --KEQVETLWPWIDKCQNNLEEI--KFCL--DPAEGENSIAKLKSLQKEMDQHFGMVEL- 2967
Query: 1488 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK-----KQTENPKELDERVT 1542
LN+ N S+ E+ EV V + ++QK +Q + K E +T
Sbjct: 2968 ----------LNNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHSKKFCLENMT 3015
Query: 1543 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1602
+ E+ E K+QL+ C K + + M T++ +++ +
Sbjct: 3016 QKFKEFQEVSK---ESKRQLQ-CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3071
Query: 1603 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL---VEDKLSLLNSNWIAV 1659
+D K +++ + K ++V ++T+ + TL V++K S L + +
Sbjct: 3072 VDL----AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3127
Query: 1660 TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE-DVLKRLKA 1718
+ N + E FD +D + A+TL + E K K+ + L
Sbjct: 3128 G----HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3183
Query: 1719 ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 1778
N + +T + + +L+ + D + + Q ++L R A +++ +K
Sbjct: 3184 NANKTCKMMLATEETSPDLVGIKRD--LEALSKQCNKLLDRAQAREEQVEG-----TIKR 3236
Query: 1779 LEQFNSDIQK---LLEPLEA--EIQQGVNLKEEDFNKDMN----------EDNEGTVKEL 1823
LE+F S +++ LL+ E E Q V ++ E N+ +N E +G +++
Sbjct: 3237 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3296
Query: 1824 LQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQAD 1883
G L Q + ++ + + L +QR + E +++ +
Sbjct: 3297 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3356
Query: 1884 DLLKCLDDIEKKLASLPEPRDERKI--------KEIDRELQKKKEELNAVRRQAEGLSED 1935
LL + D E+ +A+ P E K+ K + R L +K + ++R+ E +
Sbjct: 3357 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI--- 3413
Query: 1936 GAAMAVEPT-QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-ISYVP 1993
A EP ++++ K+ ++S++ LN A+ T + LE IS V
Sbjct: 3414 --ATTAEPADKVKILKQLSLLDSRWEAL--LNKAE------------TRNRQLEGISVVA 3457
Query: 1994 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 2053
+ + +++ L +E+ L + L +Q K ++D + + + H
Sbjct: 3458 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL---HQ 3514
Query: 2054 KKTAALQSATPVERVKLQEALSQLDFQ---WEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 2110
+ R S+LDF + ++ + R +++ + F D
Sbjct: 3515 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEV 3574
Query: 2111 IFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQDGIGQRQTVVRTLNATGEEIIQQ 2168
WL E L K + + +K L+ LQ+ I R+ V G E+++Q
Sbjct: 3575 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3634
Query: 2169 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD- 2227
++ + I+Q+KL ++ R++++ K +D K LE+ + E WL++ +
Sbjct: 3635 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3694
Query: 2228 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2287
+ S + K ++ + + K L +E + +L LNE +L P E L
Sbjct: 3695 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG--L 3752
Query: 2288 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2347
E + + N ++ VS + +K EI+A I + + ++ + L W++ +L
Sbjct: 3753 EKMVAEDNERYRLVSDTITQKVEEIDAAIL-------RSQQFDQAADAELSWITETEKKL 3805
Query: 2348 EIYN-----QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK---EKPATQPVKRKL 2399
Q VQ+T + D+ + L K H + Q +K+KL
Sbjct: 3806 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3865
Query: 2400 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2459
+ + + + ++ E R Q + A +LV Q T E L
Sbjct: 3866 DKVLKNYDTICQINSE-RYLQLERAQ-------------SLVNQFWETYEELWPWLTETQ 3911
Query: 2460 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2519
S++ ++PA A L + ++ Q+ + + E+I + K + + +
Sbjct: 3912 SIISQLPAPA--------------LEYETLRQQQE---EHRQLRELIAEHKPHIDKMNKT 3954
Query: 2520 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2579
PQL EL S E +I ++ + +++E ++ R L+E + ST
Sbjct: 3955 GPQLLEL-----------SPGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQST 4002
Query: 2580 QWLEAKEEAEQVLGQARAKLESWKEGPYT---VDAIQKKITETKQLAKDLRQWQTNVDVA 2636
Q+ ++ +Q+L +E ++ P V+ I+++I+E K ++ D+ + Q +
Sbjct: 4003 QF---HDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 4059
Query: 2637 NDLALKLL-RDYSADDTRKVHMITENINAS---WRSIHKRVSEREAALEETHRLLQQFPL 2692
+++ R D + + ++ W +IH V EREA L + L ++F
Sbjct: 4060 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC 4119
Query: 2693 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD-LQGEIEAHTDVYHNL 2751
D + + + + L+D +++ + E +++ D LQ E+ D+ NL
Sbjct: 4120 DHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEEL----DIVINL 4175
Query: 2752 DENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 2811
L + G D ++++ +D +N W L K + LE + + LQ
Sbjct: 4176 GSE----LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4231
Query: 2812 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 2871
+ W+ + +L+ +PIG D V++Q + + FK E +
Sbjct: 4232 AVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAY------------------Q 4273
Query: 2872 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 2931
Q +E +E+L + L + ++ ++ E+ W+ L + Q K++ L
Sbjct: 4274 QQIE-MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4332
Query: 2932 LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 2991
L + Q A DEL L E + +PVG +++ L K L+ ++ + V V
Sbjct: 4333 LGQFQHALDELLAWLTHTEGLLSEQKPVGG-DPKAIEIELAKHHVLQNDVLAHQSTVEAV 4391
Query: 2992 NDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 3039
N L NL + LE LN RW+ + E R +QL A R
Sbjct: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4440
Score = 313 bits (803), Expect = 2e-84
Identities = 505/2706 (18%), Positives = 1066/2706 (39%), Gaps = 308/2706 (11%)
Query: 399 GSKLIGTGKLSEDEE-------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN- 450
G+ L G G + EE T +++ M ++ +E L + +K + L+ L LQ
Sbjct: 2413 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2472
Query: 451 -QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 509
++ + WL K + K ++ P D E +K QV+Q+K + +L+Q +V L
Sbjct: 2473 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2532
Query: 510 VVVVDESSGDHATAALEEQ-LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 568
+ + E + D A +Q L + +W + + T DR L++ + +
Sbjct: 2533 LTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLK 2592
Query: 569 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL- 627
WL EKE V+ + D N + + Q++ +L + +K +L + Q +LS
Sbjct: 2593 QWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2651
Query: 628 KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 687
++ S+ + L + WD+L +L I QA+ + T+
Sbjct: 2652 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS-----------------TQ 2694
Query: 688 EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFR 747
Q L++ ++L +D+++ L V T +A+ Q E A
Sbjct: 2695 YQSLLRSLSDKLSD----------LDNKLSSSLAVS--------THPDAMNQQLETAQKM 2736
Query: 748 KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK-QASEQLNS 806
K+ I++EK + + AQAL E + + V + +K + S QL
Sbjct: 2737 KQ-----------EIQQEKKQ--------IKVAQALCEDL-SALVKEEYLKAELSRQLEG 2776
Query: 807 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ-----MTTTAENWLKIQPTTPSEPTA 861
F + + N +++ + A +Q QQ+ + + T E K P + ++
Sbjct: 2777 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS-AKLDV 2835
Query: 862 IKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFS 919
++S +K KD L+ E+ + +++ LK +G L ++
Sbjct: 2836 LESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2895
Query: 920 DVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQ 979
V+ RE +L+ + ++Y+E + + W+ + + L + + E E + +L+
Sbjct: 2896 QVKERENKLKESLEKA--LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE-GENSIAKLK 2952
Query: 980 ALQSSLQEQQSGLYYLSTT------VKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLV 1033
+LQ + + + L+ T V E+ K+ ++ ++ + + + + L
Sbjct: 2953 SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLE 3012
Query: 1034 EHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD 1093
QK +E ++ + +Q K+ ++D+ +LG K L +
Sbjct: 3013 NMTQKFKEFQEVSKESKRQLQCAKE---QLDIH-----DSLGSQAYSNKYLTMLQTQQKS 3064
Query: 1094 IQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQWDHMCQQVYARKEALKGGL 1152
+Q ++ ++ Q + EA + + S + +++ + + + QQV + L+ L
Sbjct: 3065 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3124
Query: 1153 EKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR---------AKEEA 1203
+ Q + EM + ++E + + LQK E +K A +
Sbjct: 3125 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN 3184
Query: 1204 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1263
K K+ L TE + + +K++LE L+ L R + + +E
Sbjct: 3185 ANKTCKMMLATEETSPDLV--------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3236
Query: 1264 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHS----EDNPNQI 1319
E S L++ + L + E ++ + E I++ L+ + + + +
Sbjct: 3237 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3296
Query: 1320 RILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI------QSAQE 1370
L Q L + + +L+ N+RW+ L+++ +R L++++ Q A E
Sbjct: 3297 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3356
Query: 1371 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK 1430
+ S + E L K +A KV AQ+ QE + +Q L + ++E +K+ +
Sbjct: 3357 SLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QEQKLLQRLLDDRKSTVEVIKREGEKI 3413
Query: 1431 EAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI--------LDEVKMHLP 1482
++ + K+L + ++ A R E + L+ + L
Sbjct: 3414 ATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3472
Query: 1483 ALETKSVEQEVVQSQ---LNHCVNLYKSLSEV----KSEVEMVIKTGRQIVQKKQTENPK 1535
+E + V E + +Q L + +K+L + + + G+ + E+
Sbjct: 3473 TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3532
Query: 1536 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1595
+ ++ ++ Y E+ K R + L++ L ++ ++ L WL +L+K S
Sbjct: 3533 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV 3592
Query: 1596 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNS 1654
+ L + + + Q++I +K ++ G E LK G + +++DKL + +
Sbjct: 3593 QDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3652
Query: 1655 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDV 1712
+ +T + + L + + + + W+ ++ + L E++ K ++
Sbjct: 3653 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3712
Query: 1713 L---KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI-- 1767
K LK E + + +DS + ++ L+ R+ +E ++E N R+ +S I
Sbjct: 3713 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3772
Query: 1768 KTGKASIPLKELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED- 1815
K + + +QF+ +KL+ + ++Q + K +
Sbjct: 3773 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3832
Query: 1816 --NEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISH 1873
++ + +L++ G + ++E K + +K K + ++ + + S+R +
Sbjct: 3833 LRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3891
Query: 1874 QWYQYKRQADDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEEL 1922
Q+ ++L L + + ++ LP P + R+++E+ E + +++
Sbjct: 3892 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3951
Query: 1923 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1982
N Q LS G +++ + + +I+ ++ A + + T
Sbjct: 3952 NKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDK 4007
Query: 1983 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 2042
D LE L + +S + ++++ ++ + D E L E+LK + +
Sbjct: 4008 IDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMI 4067
Query: 2043 QSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW 2102
SG D S K +Q+ L Q+ F WE ++ + ++R+ + +E
Sbjct: 4068 ARSGGTDKDISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 4114
Query: 2103 RRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTV 2154
+F D + + + F+R + P + E A+ ++E DG+ + +
Sbjct: 4115 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDI 4171
Query: 2155 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2214
V L G E+I + D I+++ + LN W + K DR +LEE ++Q
Sbjct: 4172 VINL---GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 4228
Query: 2215 DLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV 2273
L W++ A +AS+ + +K+++E++K E +Q +++LN +
Sbjct: 4229 GLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELL 4288
Query: 2274 LVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEE 2331
L EE DK +++ L + L W + + +Q ++E + LGQ + L++L
Sbjct: 4289 LKKVT---EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-- 4343
Query: 2332 QLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQ 2383
L WL+ L Q G E E+A V A Q VE + G
Sbjct: 4344 -----LAWLTHTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGN 4396
Query: 2384 HLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2441
L + + ++ KLE L+ W+ V
Sbjct: 4397 DLIESSAGEEASNLQNKLEVLNQRWQNV-------------------------------- 4424
Query: 2442 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2501
++T K ++ +L F+ +L WL+ ++ + + + + G E
Sbjct: 4425 -----LEKTEQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4475
Query: 2502 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2561
E + E + + L+ Q + + + A T I I ++ +W+ V+
Sbjct: 4476 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVE 4534
Query: 2562 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2621
L R+ +L E L + ++ + ++ L QA L +D + +I E K
Sbjct: 4535 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4594
Query: 2622 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2681
A ++ + + + L D + + ++ + W + +R+ ER +L+
Sbjct: 4595 FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLD 4654
Query: 2682 ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2741
+ + +QF K + WL E+E + + + + D +K + Q ++ Q +
Sbjct: 4655 DARKRAKQFHEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSL 4708
Query: 2742 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSD 2801
A VY + + + +DD + L L + KW + KS+ ++ LE +
Sbjct: 4709 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4768
Query: 2802 QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 2861
+ +LQ L+ WL + +L+ P+ GD V D H+AF++EL +
Sbjct: 4769 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT------ 4822
Query: 2862 LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 2921
++ L + REL E +++ + ++ Q +E++T WE + S
Sbjct: 4823 -------------SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISK 4867
Query: 2922 QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVK 2975
Q +++ L + +E L L +AE + D LID ++ ++K++
Sbjct: 4868 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4927
Query: 2976 ALRGEI 2981
R E+
Sbjct: 4928 EKRAEL 4933
Score = 277 bits (708), Expect = 2e-73
Identities = 491/2725 (18%), Positives = 1089/2725 (39%), Gaps = 258/2725 (9%)
Query: 341 QTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGS 400
Q L+E+L W+ + E +L+ QG++ + ++D + D+ Q + + +
Sbjct: 2117 QDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2176
Query: 401 KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKELND 458
K + T S + +Q +M L++R+ E + + + ++L ++L
Sbjct: 2177 KFMETTDPST--ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2234
Query: 459 WL-TKTEERTRKMEEEPLGPDLEDLKRQVQQ-------HKVLQEDLEQEQVRVNSLTHMV 510
+L TKT+ T E + G D+ +L + +Q+ HK + LE + ++
Sbjct: 2235 FLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHK---KHLEVLHSLLKEISSHG 2288
Query: 511 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 570
+ D++ T L ++ K + D + ++ Q+ L +Q L + +W
Sbjct: 2289 LPSDKALVLEKTNNLSKKFKEMEDT----IKEKKEAVTSCQEQLDAFQVLVKS---LKSW 2341
Query: 571 LSEKEDAVNKIHTT-GFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 629
+ E V + + G +D + L +KL + +SLK + + N
Sbjct: 2342 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQ--------------EKWSLKTPEIQKVNN 2387
Query: 630 KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQ--AVTTTQPSLTQTTVMETVTTVTT- 686
++ L N + V K+ A + AV + + T T +T+
Sbjct: 2388 SGIS------LCNLI----SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2437
Query: 687 -REQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL----QSP 741
++ + H E+L K ++ ++ + + + W+ + Q+P
Sbjct: 2438 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2497
Query: 742 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 801
A E + +++ + E E + K+Q+ L+E+ + A KQ
Sbjct: 2498 --APTDTEAVKTQVEQN-KSFEAELKQNVNKVQELKDKLTELLEENPDTP-EAPRWKQML 2553
Query: 802 EQLNSRWIEFCQLLSERLNWLEYQ-NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 860
+++S+W E QL +R LE NN+ F QL+Q E + + +P
Sbjct: 2554 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2613
Query: 861 AIKSQLKICKDEVNRLSGLQPQIERLKIQSIA-LKEKGQGPMF---LDADFVAFTNHFKQ 916
+ +Q + + + + +PQ E+L L G+ P + A T +
Sbjct: 2614 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2673
Query: 917 VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 976
+ + R + + +YQ + ++ + + KLS T + M Q+L
Sbjct: 2674 LTGQLSDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLE 2731
Query: 977 ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSE-ISRKYQSEFEEIEGRWKKLSSQLVEH 1035
Q ++ +Q+++ + +++S E + + + E I +K + + H
Sbjct: 2732 TAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH 2791
Query: 1036 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1095
Q L+ + Q + + W+ + P ++L+ +K + +
Sbjct: 2792 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2851
Query: 1096 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1155
G+ + + + + L+ +L + T WD +QV R+ LK LEK
Sbjct: 2852 AQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 2911
Query: 1156 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTE 1215
+ ++ + + W+ + + E F P E + ++ ++K ++E Q V+LL
Sbjct: 2912 LKYKEQVETLWPWIDKCQNNLEEIKF-CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNN 2970
Query: 1216 SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKAN 1275
+ NS+++ + +E + E ++L + +L+ K LE + + E +++
Sbjct: 2971 TANSLLSVCE-IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESK 3029
Query: 1276 KWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI---LAQTLT----- 1327
+ L + +L +++ G ++ L L+ + + +Q+ + LAQ L
Sbjct: 3030 RQLQCAKEQLDIHDSL-GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD 3088
Query: 1328 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1387
G D L+ ++ET L ++ + LE +Q + ++ + D
Sbjct: 3089 SKGTSDVLL--QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD 3146
Query: 1388 QLAAYIADKVDAAQMPQEAQKIQSDLTSHE----------------ISLEEMKKHNQGKE 1431
+L + DA + ++ + I++ L E ++ EE G +
Sbjct: 3147 ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3206
Query: 1432 AAQRVLSQ-----IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALET 1486
LS+ +D AQ + + V + ++ F +L+E ++L + + H +
Sbjct: 3207 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE---FYSKLKEFSILLQKAEEHEESQGP 3263
Query: 1487 KSVEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTAL 1544
+E E + QLN K + ++ + + V G+ ++Q ++ + + L+ + +
Sbjct: 3264 VGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDV 3323
Query: 1545 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1604
+ L KV +R QL++ L + + + L W+ T+ + + +
Sbjct: 3324 NARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK 3383
Query: 1605 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRA 1663
+++ K Q+ ++ +K ++ I GE + T + + + +LSLL+S W A+ ++A
Sbjct: 3384 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3443
Query: 1664 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELN 1721
E L + F + ++ + +W+ + L E Q E+ + + KA +
Sbjct: 3444 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3503
Query: 1722 DIRPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL 1776
DI Q+ ++++R D + +V+ ++ F+ + + I+ + S
Sbjct: 3504 DIINHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSR 3555
Query: 1777 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRI 1834
EL Q K+ E E+ +N + +K +D EG K+ + R+
Sbjct: 3556 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRV 3609
Query: 1835 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1894
E + + KQ + Q N L+ L+ + L I + K + D+ K D+ K
Sbjct: 3610 LQE---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3666
Query: 1895 KLASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRW 1952
L + R++ EL K E+ + + + L + A+ A + +L K
Sbjct: 3667 TLEQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEA 3723
Query: 1953 REIESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 2008
+ ++ ++ A + V RE ++ ED V T ++ + A+L
Sbjct: 3724 KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAIL 3782
Query: 2009 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 2068
+Q A D + K+ SL +I+ Q+S ++ + + L+ ++ +
Sbjct: 3783 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3842
Query: 2069 -----KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ------- 2114
K+ A S+ + Q +K++K+ K+ + E++ + + NQ
Sbjct: 3843 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 3902
Query: 2115 ---WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2169
WLTE + + + P E + + ++L++ I + + + +N TG ++++ S
Sbjct: 3903 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 3962
Query: 2170 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADN 2228
SI QEK + + + ++ + + R L+E + ++F +++ + LE +
Sbjct: 3963 PGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4021
Query: 2229 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDK 2286
+ P + +++KE++ + K + ++ Q + + L + G ++ + + ++
Sbjct: 4022 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4081
Query: 2287 LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIR 2344
+++KL Q W + + E+ EA++ D+ +L +K +H L++ + +
Sbjct: 4082 VQDKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQ 4132
Query: 2345 NQLEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVK 2396
+ + P + Q+ E A + Q +++ +++ G L +P VK
Sbjct: 4133 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4192
Query: 2397 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE 2456
+ +++L+S W ++N+ ++ I KLE
Sbjct: 4193 KSIDELNSAWDSLNKAWKD-----------------------------------RIDKLE 4217
Query: 2457 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2516
+ A + + DW+ + + S + DLE + + I + K +
Sbjct: 4218 EA------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4271
Query: 2517 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2576
Q++ ++E L A+ L K + + + + D + ++ WD ++E + NR+ +L L
Sbjct: 4272 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4331
Query: 2577 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2636
Q+ A +E L L K AI+ ++ + L D+ Q+ V+
Sbjct: 4332 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4391
Query: 2637 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2696
N L+ + ++ + E +N W+++ ++ +R+ L+ R + F ++E
Sbjct: 4392 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4451
Query: 2697 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2756
WLT+ E + + L + KE + ++ EA + Y +L + Q
Sbjct: 4452 LQQWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQ 4505
Query: 2757 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2816
++L S + + + ++N+ KW + K ++ LE + + H SLQ+ + W
Sbjct: 4506 QMLARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4564
Query: 2817 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQP 2873
L + L+ + V Q D H+ F E+ + I+ +T ++ F +Q
Sbjct: 4565 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4624
Query: 2874 LEGLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQR 2923
+ ++ L + + R + V + L RK+A++ + W KL +W
Sbjct: 4625 VVLIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLE 4675
Query: 2924 KIDETLERLQELQEATDELDLKLRQ 2948
+ +++L+ E+ D++ +L Q
Sbjct: 4676 ESEKSLDSELEIANDPDKIKTQLAQ 4700
Score = 226 bits (576), Expect = 3e-58
Identities = 345/1758 (19%), Positives = 713/1758 (40%), Gaps = 172/1758 (9%)
Query: 328 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 387
+ L E+ ++ R+Q ALE +LSW++ E+ + Q S + +VVK Q + L
Sbjct: 3339 AQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD 3398
Query: 388 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 447
+ V I + G K+ T + + ++ ++ +Q++LL+SRWE L + + L + +
Sbjct: 3399 RKSTVEVIKREGEKIATTAEPA--DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3456
Query: 448 LQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 505
Q ++ L+ LN+WLT E+R + EP+G L+ Q+ QHK L++D+ + N
Sbjct: 3457 AQQFHETLEPLNEWLTTIEKRL--VNCEPIGTQASKLEEQIAQHKALEDDI----INHNK 3510
Query: 506 LTHMVVVVDES----SGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 561
H V + +S S ++ +L + I + R LLQ L +
Sbjct: 3511 HLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFG 3570
Query: 562 EEQCLFSAWLSEKEDAVNKI-----HTTGFKDQNEMLSSLQKLAVLKAD---------LE 607
E++ WL+E D ++K+ T G Q L LQ+ +L+ LE
Sbjct: 3571 EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLE 3630
Query: 608 KKKQSMGKLYSLKQDLLSTLKNK--------------------------SVTQKTEAWLD 641
KQ+ G + QD L +K + S ++ WLD
Sbjct: 3631 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3690
Query: 642 NF---ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK-HAQE 697
++ V K E+++ + + + +++++ V++ LV A+E
Sbjct: 3691 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRARE 3750
Query: 698 ELPP--PPPQKKRQITVDSEIRKRLDVDITELH------------SWITRSEAVLQSPEF 743
L ++ ++ D+ +K ++D L SWIT +E L S
Sbjct: 3751 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3810
Query: 744 AIFRKEGNFSDLK-EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE 802
++ + L+ +K +E + + + D +S ++ E S+K+ +
Sbjct: 3811 IRLEQDQTSAQLQVQKTFTMEILRHKDI--IDDLVKSGHKIMTACSEE--EKQSMKKKLD 3866
Query: 803 QLNSRWIEFCQLLSERLNWLEYQNNII-AFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 861
++ + CQ+ SER LE +++ F+ ++L T ++ + P E
Sbjct: 3867 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3926
Query: 862 IKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMF-LDADFVAFTNHFKQVFSD 920
++ Q + + ++ +P I+++ L E G F + +VA + Q+ D
Sbjct: 3927 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3986
Query: 921 VQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQA 980
V+ R L ++ + + I +++ +L P + E +++++ E +
Sbjct: 3987 VKKRAVALDEAIS--QSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4044
Query: 981 LQSSLQEQQSGLYYLSTTVKEM---SKKAPSEISRK-YQSEFEEIEGRWKKLSSQLVEHC 1036
+ +++ Q L +EM S +IS K Q + +++ W+ + + + E
Sbjct: 4045 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4104
Query: 1037 QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKE-EWPALGDSEILKKQLKQCRLLVSDIQ 1095
KL + M K +L + + F+++ E P + D ++K+Q + + +I
Sbjct: 4105 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI-DPSVVKQQQEAAETIREEID 4163
Query: 1096 TIQPSLNSV-NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1154
+Q L+ V N G + I EP+ ++ + ELN+ WD + + R + L+ ++
Sbjct: 4164 GLQEELDIVINLGSELIAACGEPD-KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4222
Query: 1155 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1214
V Q L + +W+ A + + +++ +EE+K+ K EA Q++ +++ L
Sbjct: 4223 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4282
Query: 1215 ESVNSVIAQAPPVA-QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEK 1273
++ + + + ++ L L + L R+ + LE + L++
Sbjct: 4283 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4342
Query: 1274 ANKWLNEVEFKLKTTENIPGGAEEISEVLDS---LENLMRHSEDNPNQIRILAQTLTDGG 1330
WL E L + + G + I L L+N + + + L +
Sbjct: 4343 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4402
Query: 1331 VMDELIN--EELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1388
+E N +LE N RW+ + E+ +R++ L+ +++ A+ + +Q+ LT ++
Sbjct: 4403 AGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERH 4462
Query: 1389 LAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEE-----MKKHNQ-----GKEAAQR 1435
L A +P+ A++ + ++ + + EE M+K Q K A
Sbjct: 4463 LLA----SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4518
Query: 1436 VLSQIDVAQKKLQDVSMKF--------RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1487
+ I+ ++K + V K F LQ+ L + + L
Sbjct: 4519 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4578
Query: 1488 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLH 1547
S+ + V Q++ ++ + ++ + KTG + Q ++ + + +++
Sbjct: 4579 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4638
Query: 1548 YNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEV 1607
+ ++ ++ ER + L+ K +++ + + L EWL ++ L + P + +++
Sbjct: 4639 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4698
Query: 1608 AWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1665
A K QK + + + G +L KT L ++D LS L W + ++ E
Sbjct: 4699 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4758
Query: 1666 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK-----KKPQQKEDVLKRLKAEL 1720
N L E F + + W+ + + L E + D K + EL
Sbjct: 4759 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4818
Query: 1721 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS--HRIKTGKASIPLKE 1778
V + + A L+ D V+ Q+ EL+ R+ + K + L++
Sbjct: 4819 GKRTSSVQALKRSARELIEGSRDD-SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4877
Query: 1779 LEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1833
E+F+S + LLE L AE +Q GV +ED + + + ++ +K+L ++ L +
Sbjct: 4878 AEEFHSVVHALLEWL-AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKA 4936
Query: 1834 IT------------------------DERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1869
T R E + +Q Q +AL L + +++ L
Sbjct: 4937 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIA--KQELL 4994
Query: 1870 EISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1929
E W Q+ L D +K++ P++ ++K + E Q EE+ +
Sbjct: 4995 EALLAWLQWAETT------LTDKDKEVI----PQEIEEVKALIAEHQTFMEEMTRKQPDV 5044
Query: 1930 EGLSEDGAAMAVEPTQIQ 1947
+ +++ A +P+ +Q
Sbjct: 5045 DKVTKTYKRRAADPSSLQ 5062
Score = 221 bits (564), Expect = 8e-57
Identities = 112/232 (48%), Positives = 154/232 (66%), Gaps = 5/232 (2%)
Query: 6 SDEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGST 65
+DER+ VQKKTFTKW+N K K H+ +L+ DL+DG L+ LLE L+G LP+EKG
Sbjct: 70 ADERDKVQKKTFTKWINQHLMKVRK-HVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRM 128
Query: 66 RVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMA 125
R H L NV AL L+ V LVNI + DI DGN KLTLGLIW IILH+Q+ ++ ++
Sbjct: 129 RFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDI--HVTG 186
Query: 126 GLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQ 185
+ ++++ LL W +Q+T Y + NFTT W DG NA+IH +RPDL D N+V
Sbjct: 187 ESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV- 245
Query: 186 QSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 237
QS LEHAF +A ++G+ +LLDPEDVD + PD+KS++ Y++SL+ P+
Sbjct: 246 QSNLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK 296
Score = 205 bits (521), Expect = 8e-52
Identities = 284/1564 (18%), Positives = 642/1564 (41%), Gaps = 148/1564 (9%)
Query: 264 LHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA-YTQAAYVTTSDPTRSPFPSQHLEAPE 322
++H H Q +++ + + K +S ++Q Y+ + + S
Sbjct: 3506 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCN 3565
Query: 323 DKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYM 382
K FG E EV L + + + LS L + + + + +++ V+++
Sbjct: 3566 AKIFG----EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE--------- 3612
Query: 383 MDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH 442
D+ + V L G +L+ + + DE +Q+++ + +R++ + S + L
Sbjct: 3613 -DILLRKQNVDQALLNGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLE 3669
Query: 443 RVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQ 500
+ L + + +EL WL K E E + L E+ + + K L+++ + +
Sbjct: 3670 QALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG--EEASQAQMRPKELKKEAKNNK 3727
Query: 501 VRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRL 560
++SL + + E A LE+ + +R+ + + + +L+ Q+
Sbjct: 3728 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3787
Query: 561 TEEQCLFSAWLSEKEDA-------------------VNKIHTTGFKDQNEMLSSLQKLA- 600
+ +W++E E V K T +++ L K
Sbjct: 3788 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3847
Query: 601 -VLKADLEKKKQSMGKLYS--LKQ-DLLSTLKNKSVTQ--KTEAWLDNFARCWDNLVQKL 654
++ A E++KQSM K LK D + + ++ Q + ++ ++ F ++ L L
Sbjct: 3848 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 3907
Query: 655 EKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ--EELPPPPPQ------- 705
++ + ISQ P+L T+ + +++ +H +++ PQ
Sbjct: 3908 TETQSIISQLPA---PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3964
Query: 706 -----KKRQITVDS-------EIRKR---LDVDITELHSWITRSEAVLQSPEFAIFRKE- 749
+++ + D+ +++KR LD I++ + + + +L+S E + R
Sbjct: 3965 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4024
Query: 750 -----GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMV------NEGVNADSIK 798
+KE+++ + + KLQ + + E+M+ ++ ++A +++
Sbjct: 4025 PPSISAEVEKIKEQISENKNVSVD-MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4083
Query: 799 QASEQLNSRWIEFCQLLSER-LNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 857
+Q+ W L+ ER L+ F+ L +++++
Sbjct: 4084 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4143
Query: 858 EPTAIKSQLKICKDEVNRLSGLQPQIE---RLKIQSIALKEKGQGPMF---LDADFVAFT 911
+P+ +K Q + + + GLQ +++ L + IA + P+ +D A+
Sbjct: 4144 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4203
Query: 912 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 971
+ K + E+ +Q ++YQ+ + A+ WV + KL+ TD E +
Sbjct: 4204 SLNKAWKDRIDKLEEAMQAA------VQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 4257
Query: 972 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEFEEIEGRWKKLSS 1030
+Q++ EL+ +S +QQ + L+ + + KK E + Q E++ W L
Sbjct: 4258 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 4317
Query: 1031 QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 1090
+++ KLE + L + Q+ + L W+ + L E+ P GD + ++ +L + +L
Sbjct: 4318 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4377
Query: 1091 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1150
+D+ Q ++ +VN+ G + + E AS L+ +L+ LN +W ++ ++ RK+ L G
Sbjct: 4378 QNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDG 4437
Query: 1151 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKV 1210
L + ++ ++ +W+T E L P+ ++ + + KE
Sbjct: 4438 ALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4497
Query: 1211 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1270
K L + ++A+ P A+ + +++ L ++ + T+LN + LEE E +
Sbjct: 4498 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4557
Query: 1271 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1330
L+ WL + E L + + +D + + QI L +T T
Sbjct: 4558 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4617
Query: 1331 VMDE-----LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI 1385
+ LI L + SRW ++ + V R + L+ + + A++ ++ + E L
Sbjct: 4618 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4677
Query: 1386 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQK 1445
+K L + + ++ + KI++ L H +E +K K + ++ + K
Sbjct: 4678 EKSLDSEL-------EIANDPDKIKTQLAQH----KEFQKSLGAKHSVYDTTNRTGRSLK 4726
Query: 1446 ----------KLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPAL------ 1484
KL D+ + R + K + +L+E+ + + L AL
Sbjct: 4727 EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYR 4786
Query: 1485 -ETKSVEQEVVQSQLNHCVNL-------YKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1536
E + E + V ++ +NL K L + S V+ + ++ R++++ + ++
Sbjct: 4787 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR-DDSSW 4845
Query: 1537 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1596
+ ++ L + + A ++ +LE L+ + + ++ L EWLA + L +
Sbjct: 4846 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4905
Query: 1597 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDKLSLLNSN 1655
L + + K K++E+++ L T +G+ + + T ++ ++++ +
Sbjct: 4906 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4965
Query: 1656 WIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR 1715
+ V + A++ L + + ++ + W+ A+T L + +K+ Q+ + +K
Sbjct: 4966 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5025
Query: 1716 LKAE 1719
L AE
Sbjct: 5026 LIAE 5029
Score = 178 bits (452), Expect = 8e-44
Identities = 527/2759 (19%), Positives = 1063/2759 (38%), Gaps = 415/2759 (15%)
Query: 452 KLKELNDWLTKTEE--------RTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 503
KLK +N L T+ T+ EEE + D +++ + K + ++++++
Sbjct: 1210 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 1269
Query: 504 NSLTHMV----VVVDESSGDHATAALE-----EQLKVLGDRWANICRWTEDRWVLLQDI- 553
++L + + DE + L+ E+ L +RW N+ ++R L+ I
Sbjct: 1270 HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 1329
Query: 554 -LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQS 612
LK+ R T W+ + E KI ++ + + L + +L +++E K+
Sbjct: 1330 KSLKYYRDTYHP--LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1387
Query: 613 MGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 672
M + + +T+K+ + T + D+ + K S A Q +
Sbjct: 1388 MDECQKYAEQYSATVKDYELQTMT------YRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1441
Query: 673 TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWIT 732
T + T+ T+ +K A + L ++K +++ E ++ ++ EL W++
Sbjct: 1442 DLRTRYTALVTLMTQ---YIKFAGDSLKRLEEEEK---SLEEEKKEHVE-KAKELQKWVS 1494
Query: 733 RSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV 792
L+ E K G K+K+++ E + K +L +A ++ Q + + +
Sbjct: 1495 NISKTLKDAE-----KAGKPPFSKQKISS--EEISTKKEQLSEALQTIQLFLAKHGD--- 1544
Query: 793 NADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ 852
K E+ N L +++ L+ N++ F L+QL++ T+ + +K+
Sbjct: 1545 -----KMTDEERNE--------LEKQVKTLQESYNLL-FSESLKQLQESQTSGD--VKV- 1587
Query: 853 PTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN 912
E + + + K+++ + L Q E I G F+ D
Sbjct: 1588 -----EEKIVAERQQEYKEKLQGICDLLTQTENRLI--------GHQEAFMIGDGTVELK 1634
Query: 913 HFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET--KLSIPQLSVTDYEI 970
+ Q++++ELQ Q + A+ V+ +E K + +LS D +
Sbjct: 1635 KY-------QSKQEELQKDM--------QGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1679
Query: 971 MEQRLGE--LQALQSSLQEQQSGLYY---LSTTVKEMSKKAPS-----EISRKYQSEFEE 1020
+EQ+L E ++ Q +L+ +QS ++T +KE ++K + E K ++ +
Sbjct: 1680 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1739
Query: 1021 IEGRWKKLSSQLVEHCQKLEE-----QMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 1075
+ K +H Q +E+ Q + + + E DV +
Sbjct: 1740 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1799
Query: 1076 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD 1135
++ +K Q ++S Q + + S +K PE +L+ +KEL ++
Sbjct: 1800 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYE 1859
Query: 1136 HMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEE 1195
+ + + E+ D +E W+ Q+E+E + + L ++
Sbjct: 1860 TALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR 1919
Query: 1196 MKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ------------EALKKELETLTTNY 1243
K E+ + ++ +T S N V+ A ++ ++++L+ T +
Sbjct: 1920 QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRF 1979
Query: 1244 QWL---CTRLNGKCKTLEEVWACWHE----LLSYLE----KANKWLNE--------VEFK 1284
+ L C L K L + + + + LL+ L+ A+K L+E ++ +
Sbjct: 1980 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 2039
Query: 1285 LKTTENIPG----------------------------GAEEISEVLDSL----ENLMRHS 1312
L+ T+ + G +I + LD + E+L +
Sbjct: 2040 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSV 2099
Query: 1313 EDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEA------------VRRQKL 1360
+ +++I TLT + + ++E L+ + L E+ + + +
Sbjct: 2100 NERNEKLQI---TLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIM 2156
Query: 1361 LEQSIQSAQETEKSLH-LIQESLTFIDKQLAAYIADKVD--AAQMPQEAQKIQSDL---- 1413
LEQ I Q + +++ +++ + D A+ + K+ +A+ + + K + L
Sbjct: 2157 LEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKME 2216
Query: 1414 ---TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 1470
T E+ +K E + L+++DV K + ++S Q +QES
Sbjct: 2217 ELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELS-------------QYMQES 2263
Query: 1471 KMILDEVKMHLPALET--KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK 1528
E K HL L + K + + S + +LS+ E+E IK ++ V
Sbjct: 2264 TSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTS 2323
Query: 1529 KQTENP-------------KELDERVTALKLHY--NELGAKVTERKQQLEKCLKLSRKMR 1573
Q + KE ++V ++ + +LG + + K+ EK + +++
Sbjct: 2324 CQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ 2383
Query: 1574 KEMN---VLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEV 1630
K N L ++A +AV+ + L+ E G AT E L SI +
Sbjct: 2384 KVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE---GTATNTEEFWANKGLTSIKKD 2440
Query: 1631 GEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 1690
+ L++DK++ LN+ + EE ++ QK +T TKW
Sbjct: 2441 MTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT-------ATKW 2493
Query: 1691 IIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLM--------ANRG 1742
Q ++E K Q +++ K +AEL KV +D+ L+ A R
Sbjct: 2494 --QQTPAPTDTEAVKTQVEQN--KSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRW 2549
Query: 1743 DHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVN 1802
++ + ELN I + K ++S L + + + +++ L +E E+ V
Sbjct: 2550 KQMLTEIDSKWQELNQ--LTIDRQQKLEESSNNLTQFQTVEAQLKQWL--VEKELMVSV- 2604
Query: 1803 LKEEDFNKDMNEDNEGTVKELLQR--------------GDNLQQRITDERKREEIKIKQQ 1848
L + +M V+ LLQ G + R ++ I +K+Q
Sbjct: 2605 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGI-VKEQ 2663
Query: 1849 L--LQTKHNALKDLRSQR---RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1903
L + K ++L S R +A+ S Q+ R D L LD+ K +SL
Sbjct: 2664 LAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN--KLSSSLAVST 2721
Query: 1904 DERKIKEIDRELQKKKEELNAVRRQ---AEGLSEDGAAMAVEP-TQIQLSKRWREIESKF 1959
+ + QK K+E+ ++Q A+ L ED +A+ E + +LS R++E
Sbjct: 2722 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELS---RQLEGIL 2778
Query: 1960 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV---EQLLNA 2016
F+ + + V+ L+ + S +++ QA L+ EQ +
Sbjct: 2779 KSFKDVEQKAENHVQH-----------LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2827
Query: 2017 PDLCAKD-FEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALS 2075
P D E L K K+ +L S + ++ L E+ LQ L+
Sbjct: 2828 PISAKLDVLESLIKDH---KDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLN 2884
Query: 2076 QLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQI---PENW 2132
+ W+ NK K+R+ + S+EK ++ ++ W+ + + L + + P
Sbjct: 2885 TIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG 2944
Query: 2133 EHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC 2192
E++ K LK LQ + Q +V LN T ++ + D ++ ++ SL + V
Sbjct: 2945 ENSIAK--LKSLQKEMDQHFGMVELLNNTANSLL-SVCEIDKEVVTDENKSLIQKVDMVT 3001
Query: 2193 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-------DNIAS----------IPLE 2235
+QL +K LE EFQ E L+ A D++ S + +
Sbjct: 3002 EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3061
Query: 2236 PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLK--- 2292
Q LK +++ K L ++L + K ++ VL+ +E L ++
Sbjct: 3062 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSD----VLLQVETIAQEHSTLSQQVDEKC 3117
Query: 2293 ---QTNLQWI----KVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRN 2345
+T LQ I R + + E + ++ + + + E L++Q + +L +
Sbjct: 3118 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEA 3177
Query: 2346 QLEIYNQPNQEGPFDVQETEIA-----------------------VQAKQPDVEEILSKG 2382
+ + N+ + E + QA++ VE + +
Sbjct: 3178 LMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRL 3237
Query: 2383 QHLYKEKPATQPVKRKLED-------LSSEWKAVNRLL-----------QELRAKQPD-- 2422
+ Y + + +K E+ + E + +N+ L + L+ KQ D
Sbjct: 3238 EEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVN 3297
Query: 2423 -LAPGLTTIGASPTQTVTLV--TQPVVTKETAISKLEMPSSLMLEVPAL--ADFNRAWTE 2477
L GL A T T L V + ++K + L+ L F A
Sbjct: 3298 WLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALES 3357
Query: 2478 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 2537
L W+ ++++ +Q+ + + + I +QK + L+ R+ +E + + + T
Sbjct: 3358 LLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAT-T 3416
Query: 2538 SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 2597
+ + I ++ + ++W+ + + R +QL + + Q+ E E + L
Sbjct: 3417 AEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEK 3476
Query: 2598 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHM 2657
+L + + ++++I + K L D+ ++ A + L S +D V
Sbjct: 3477 RLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQS 3536
Query: 2658 ITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRK 2717
+ + I ++ R L++ + F D + + WL E +
Sbjct: 3537 KLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH---------DKL 3587
Query: 2718 ERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDE---NSQKILRSLEGSDDAVLLQRR 2774
+L + L KQ +L+ E N+D+ N ++L+ G D+ +++Q +
Sbjct: 3588 SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTG-DEVLIIQDK 3646
Query: 2775 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDE-LSRQAPIGGD 2833
L+ + ++ ++ K S ++ LE + +RLH + +EL WL + E LS + +
Sbjct: 3647 LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG 3706
Query: 2834 FPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQP---LEGLEKLYQEPRELPPE 2890
A Q Q + K+E K + ++ S E L P EGLEK+ E
Sbjct: 3707 EEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAE-----DN 3760
Query: 2891 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-DLKLRQ 2948
ER + V+ + ++ EE+ + L S + + D L + E ++ L D++L Q
Sbjct: 3761 ERYRLVSDTITQKVEEI----DAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3815
Score = 38.9 bits (89), Expect = 0.095
Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 27/168 (16%)
Query: 2810 LQELLVWLQLKDDELSRQAPIGGDFPAVQKQ----NDVHRAFKR-ELKTKEPVIMSTLET 2864
+Q+LL W+ +L R G D P+V+ +VHRA + E KE I T
Sbjct: 648 VQDLLNWVDEMQVQLDR-TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 706
Query: 2865 VRIFLT-EQPLEGLEKLY--------QEPRELPP----EERAQN-VTRLLRKQAEEVNTE 2910
+ LT + L LE Y + R L RA N + L K+ EEV +
Sbjct: 707 APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYD 766
Query: 2911 WEKLNL-------HSADWQRKIDETLERLQELQEATDELDLKLRQAEV 2951
W + N + A+ R++D+ E ++ +QE ++L L+ A +
Sbjct: 767 WSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 814
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 325 bits (832), Expect = 7e-88
Identities = 545/2835 (19%), Positives = 1126/2835 (39%), Gaps = 316/2835 (11%)
Query: 338 DRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQ 397
++ QT LE L + + E+S ++ +F H+ ++ +L
Sbjct: 2368 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-----------EVLH 2416
Query: 398 LGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKE 455
K I + L D+ V E+ N L+ +++ + EK+ + + +D +K
Sbjct: 2417 SLLKEISSHGLPSDKAL-VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2475
Query: 456 LNDWLTKTEERTRKMEE----EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 511
L W+ +T ++ ++ E LG LED K+ ++ + ++++ SL +++
Sbjct: 2476 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2535
Query: 512 VVDESSGDHATAALEEQLKVLGDR---------WAN------------ICRWTEDRWVLL 550
V + A AA++ VL WAN I ED +LL
Sbjct: 2536 AVTTPA--KAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2593
Query: 551 QDI-------LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS-LQKLAVL 602
+D L K Q+ EE WL + K T E + + +++
Sbjct: 2594 KDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSF 2653
Query: 603 KADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS 662
+A+L KQ++ K+ LK L L+ T + W D+ Q+L + T
Sbjct: 2654 EAEL---KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEI-DSKWQELNQLTIDRQ 2709
Query: 663 QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV 722
Q + + +LTQ +E
Sbjct: 2710 QKLEESSNNLTQFQTVEA------------------------------------------ 2727
Query: 723 DITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 782
+L W+ E ++ S + + +++V + +E A + + + + + Q
Sbjct: 2728 ---QLKQWLVEKELMV-SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2783
Query: 783 LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQN-NIIAFYNQLQQLEQM 841
++ + + +K+ + +W LS+R +W++ + + L+ L
Sbjct: 2784 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2843
Query: 842 TTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQ----SIALKEKG 897
+ +N L + P A+ QL+ + + + QI+ + S +KE+
Sbjct: 2844 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE- 2902
Query: 898 QGPMFLDADFVAFTNHFKQVFSDVQAR-EKELQTIFDTLPPM-RYQETMSAIRTWVQQSE 955
+L A+ + F DV+ + E +Q + ++Q+ + W+ +
Sbjct: 2903 ----YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2958
Query: 956 TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 1015
+ + +++E + + + +L Q + + K Q
Sbjct: 2959 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 3018
Query: 1016 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW---- 1071
+ I+ W + Q+ E KL+E + K K + ++TL W+ + L+E
Sbjct: 3019 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 3078
Query: 1072 PALGDSEI-----LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE 1126
PA G++ I L+K++ Q +V + SL SV E +++ + E
Sbjct: 3079 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-----------E 3127
Query: 1127 LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD------ 1180
K L + D + +Q++++K L+ +K Q+ E + A+E+ D
Sbjct: 3128 NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA 3187
Query: 1181 FEYKTPDELQKAVEEMKRAKEEAQ-QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETL 1239
+ K LQ + ++ K + K L+ E+ +S + E + +E TL
Sbjct: 3188 YSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL 3247
Query: 1240 TTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEIS 1299
+ C+ L K + + E+ S + + L+ + + E + E I
Sbjct: 3248 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIK 3307
Query: 1300 EVLDSLENLMRHSEDNPNQI--RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRR 1357
L LE LM S DN N+ +LA T ++ I +LE + + +L + A R
Sbjct: 3308 AFLKKLEALMA-SNDNANKTCKMMLATEETSPDLVG--IKRDLEALSKQCNKLLDRAQAR 3364
Query: 1358 QKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMP--QEAQKIQSDLTS 1415
++ +E +I+ +E L +E + K A++ + +Q P E + I L
Sbjct: 3365 EEQVEGTIKRLEEFYSKL---KEFSILLQK------AEEHEESQGPVGMETETINQQLNM 3415
Query: 1416 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 1463
++ +E + QGK+ L Q I A K L DV+ +++ L +K A
Sbjct: 3416 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3475
Query: 1464 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 1509
+LQE+ + + L +L + S E +VV++Q+ L + L
Sbjct: 3476 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3535
Query: 1510 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 1569
+ KS VE++ + G +I + + ++ ++++ L + L K R +QLE ++
Sbjct: 3536 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3595
Query: 1570 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 1629
++ + + L EWL + L + S L+ ++A KA + +I HL
Sbjct: 3596 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3655
Query: 1630 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1688
+G++LK + +++ +V+ KL +I + ++ LL + + + F ++ +
Sbjct: 3656 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3715
Query: 1689 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 1748
W+ + L S+ + L + ++EL ++ + + + N + ++
Sbjct: 3716 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3773
Query: 1749 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 1796
++ + + AI R K T ++ K LEQ ++L L+ +E E
Sbjct: 3774 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3833
Query: 1797 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 1846
+ + LK E+ + K++ ++ N + + L + + R RE ++
Sbjct: 3834 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3893
Query: 1847 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1906
++ + D +Q+ ++ + Q+ + AD L + + EKKL SL + R E+
Sbjct: 3894 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3953
Query: 1907 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1966
+ +LQ +K + R + + D + S+ ++ K N
Sbjct: 3954 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 4009
Query: 1967 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 2026
+ I + E + + L ++ TY + L E + +++ A ++E
Sbjct: 4010 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 4064
Query: 2027 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2086
L +Q+E + +++ + + ID ++ K L +P E +QE D + ++ +
Sbjct: 4065 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 4123
Query: 2087 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 2144
K R D ++ + +FH I +Q L E+ + + + P + E K K + E
Sbjct: 4124 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 4180
Query: 2145 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 2197
++ + + Q + TL GEE+I +S TD I +Q+KL + W+ + + +
Sbjct: 4181 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4240
Query: 2198 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 2256
R+ +L + + +F D ++ +++ + +PG + + K++ E + + EE+
Sbjct: 4241 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4300
Query: 2257 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 2314
Q L + G ++ + E DK ++ + + N W +++A ++ ++E
Sbjct: 4301 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 4356
Query: 2315 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2371
++ Q + L+ D + L +SPI LE Q +E +++ + +
Sbjct: 4357 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 4412
Query: 2372 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 2431
Q ++E + + + L K K + K ++D E K + L+E
Sbjct: 4413 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 4456
Query: 2432 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 2491
++ ++ KLE +L+ AL F A EL WL+ + ++
Sbjct: 4457 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 4494
Query: 2492 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2551
Q+ + GD + I + K D+ + +E + A +L ++ +EA + +++E
Sbjct: 4495 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4553
Query: 2552 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2611
+ +W V E + R+QQL+ L+ + + E+ +Q L L + K +
Sbjct: 4554 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4613
Query: 2612 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2671
++++ ++ + ++L + N+ W S+
Sbjct: 4614 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4673
Query: 2672 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 2731
+++ER+ LEE L +F L+ F+ WLT+AE T NV A+R +L+ V +
Sbjct: 4674 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4727
Query: 2732 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 2791
+ + E+ +H + LD+ L+ D VL++ L ++ +W ++ ++ +
Sbjct: 4728 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4786
Query: 2792 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 2851
L+ + + K+ H + +L+ WL+ + L + I D ++ Q H+ F++ L
Sbjct: 4787 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4846
Query: 2852 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 2911
K V +T T R L + + L E+ +W
Sbjct: 4847 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4887
Query: 2912 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 2970
+ + S + Q K++E L + +A L L + E QPV GD ID + +
Sbjct: 4888 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4945
Query: 2971 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 3023
++ KA + E+ +V + AR+L S + +++L+TRW+ +
Sbjct: 4946 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 5005
Query: 3024 QVAVEDRVRQLHEAH 3038
Q +E +RQ E H
Sbjct: 5006 QTRLEAALRQAEEFH 5020
Score = 325 bits (832), Expect = 7e-88
Identities = 536/2814 (19%), Positives = 1113/2814 (39%), Gaps = 346/2814 (12%)
Query: 330 LMESEVNLDRYQTALEE---VLSWL--LSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD 384
+ E L + Q A EE ++ WL ++ T Q D E VK Q ++ + +
Sbjct: 2597 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2656
Query: 385 LTAHQGRVGNILQLGSKLIGTGKLSEDEETEV----QEQMNLLNSRWECLRVASMEKQSN 440
L + V + +L KL T L E+ +T ++ + ++S+W+ L ++++Q
Sbjct: 2657 LKQN---VNKVQELKDKL--TELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2711
Query: 441 LHRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQ 498
L +L + E L WL + E + PL D L Q QQ ++L ++
Sbjct: 2712 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLG--PLSIDPNMLNTQRQQVQILLQEFAT 2769
Query: 499 EQVRVNSLTHMVVVVDESSGDHAT--AALEEQLKVLGDRWANICRWTEDRWVLLQDILLK 556
+ + LT + G+ + ++EQL + +W ++ DR + ++K
Sbjct: 2770 RKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVK 2829
Query: 557 WQRLTEEQCLFSAWLSEKEDAVNKIHT-----TGFKDQNEMLSSLQKLAVLKADLEKKKQ 611
T+ Q L + + D NK+ + T N+ L + QK+ K +++++K+
Sbjct: 2830 ---STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKM---KQEIQQEKK 2883
Query: 612 SMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ-- 669
+ +L +DL + +K + + + L+ + + ++ QK E + A ++
Sbjct: 2884 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2943
Query: 670 ----------------------PSLTQTTVMETVT-------------------TVTTRE 688
P + V+E++ T+ E
Sbjct: 2944 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 3003
Query: 689 QILVKHAQEELPPPPPQ---------------KKRQITVDSEIRKRLDV--DITELHSWI 731
+L+K E Q K+R+ + + K L + L WI
Sbjct: 3004 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 3063
Query: 732 TRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV------- 784
+ + L+ +F + EG S K K ++++E + F ++ + +A +L+
Sbjct: 3064 DKCQNNLEEIKFCLDPAEGENSIAKLK--SLQKEMDQHFGMVELLNNTANSLLSVCEIDK 3121
Query: 785 EQMVNEGVNA-DSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 843
E + +E + + +EQL+S+ +FC L + + E+Q QLQ ++
Sbjct: 3122 EVVTDENKSLIQKVDMVTEQLHSK--KFC-LENMTQKFKEFQEVSKESKRQLQCAKEQLD 3178
Query: 844 TAEN---------WLKIQPTTPSEPTAIKSQLKICKDEVNRL----------SGLQPQIE 884
++ +L + T A+K Q+ + K L S + Q+E
Sbjct: 3179 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE 3238
Query: 885 RLKIQSIALKEK-GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPM-RYQE 942
+ + L ++ + FL+ HF+ ++ ++ E D++ P+ R E
Sbjct: 3239 TIAQEHSTLSQQVDEKCSFLETKLQGI-GHFQNTIREMFSQFAEFDDELDSMAPVGRDAE 3297
Query: 943 TMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEM 1002
T+ + ++ KL S + + + +E L + ++ +
Sbjct: 3298 TLQKQKETIKAFLKKLEALMAS-------NDNANKTCKMMLATEETSPDLVGIKRDLEAL 3350
Query: 1003 SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1062
SK+ + R Q+ E++EG K+L E KL+E L+K + H ++
Sbjct: 3351 SKQCNKLLDRA-QAREEQVEGTIKRLE----EFYSKLKEFSILLQKAEEHEES------- 3398
Query: 1063 VDVFLKEEWPALGDSEILKKQLKQCRLLVSD-IQTIQPSLNSVNEGGQK-IKNEAEPEFA 1120
+ P ++E + +QL ++ + I+ +Q VN GQ I++ A+
Sbjct: 3399 -------QGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTST 3451
Query: 1121 SRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD 1180
LE +L ++N +W + ++V R L+ L Q L + WM EE +
Sbjct: 3452 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3511
Query: 1181 FEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLT 1240
++ ++E K + +++ V+++ + A P + + K+L L
Sbjct: 3512 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3571
Query: 1241 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1300
+ ++ L + + + LE + + LE N+WL +E +L E I A ++ E
Sbjct: 3572 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3631
Query: 1301 VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELET-------FNSRWR-ELHE 1352
+ + L +D N + L Q ++ G + L + E + F+ W E+ E
Sbjct: 3632 QIAQHKAL---EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3688
Query: 1353 EAVRRQKLLEQSIQSAQET-EKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK--I 1409
++ R +LL+Q++ +A+ E + L+ DK + D Q+++ +
Sbjct: 3689 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3748
Query: 1410 QSDLTSHEISLEEMKKHNQGKEAAQRVLS-QIDVAQKKLQDVSMKFRLFQKPAN-----F 1463
Q D+ + ++++ + G E ++ ++ + Q KL+ + +++ K +
Sbjct: 3749 QEDILLRKQNVDQALLN--GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3806
Query: 1464 EQRLQESKMI----------LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1513
EQ LQ ++ + LD+V++ L + ET+ ++ E L K K+
Sbjct: 3807 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKA 3866
Query: 1514 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1573
++ + + +++ + L++ V Y + +T++ ++++ + S++
Sbjct: 3867 LLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFD 3926
Query: 1574 KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEA 1633
+ + W+ T+ +L + +++ K EI + K + + + G
Sbjct: 3927 QAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHK 3986
Query: 1634 LKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWII 1692
+ T ++E ++ KL + N+ + E L Q + F + + + W+
Sbjct: 3987 IMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT 4046
Query: 1693 QADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRGDH 1744
+ +++ E E + QQ+E L+ L AE K++ T Q L G
Sbjct: 4047 ETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS 4106
Query: 1745 CRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ--- 1799
++ + + ++ I +K ++ + + QF+ I ++LE LE +++
Sbjct: 4107 ----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4162
Query: 1800 --GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIKQQ 1848
++ + E + ++E+ +V + L QRG+ + R K K Q
Sbjct: 4163 PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 4222
Query: 1849 LLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-D 1904
L + L +R K L++ ++ L+ + D + + L +P D
Sbjct: 4223 KLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4282
Query: 1905 ERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKFAQ 1961
+K+ + +EE++ ++ + + L + A EP + + K E+ S +
Sbjct: 4283 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDS 4342
Query: 1962 FRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCA 2021
+ +I + EE M + Y + V + L +
Sbjct: 4343 LNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSPIG 4389
Query: 2022 KDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLDFQ 2080
D E + +Q E LK K Q ++ ++ + L+ T ++ +Q+ L +L
Sbjct: 4390 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 4449
Query: 2081 WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 2140
W+ + + +RQ + + ++ +F + + WLT E L + Q P + +
Sbjct: 4450 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIEIE 4508
Query: 2141 LKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSD 2197
L + LQ+ + Q+ V +N G ++I+ S+ +AS LQ KL LN RWQ V ++
Sbjct: 4509 LAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQ 4568
Query: 2198 RKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLVEE 2255
RK++L+ F ++ + WL + + +AS PL G + KE+L +
Sbjct: 4569 RKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVCAA 4627
Query: 2256 LPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEIEA 2314
++ K L + G +L P S E D+ N LK+ +W V L E++ ++E
Sbjct: 4628 FEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKLEE 4684
Query: 2315 QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---AV 2368
+ + L+D + WL+ L + ++P+ F + E ++ V
Sbjct: 4685 ALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4737
Query: 2369 QAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDLAP 2425
+ + + E+ G HL + +K +K L + S W K V RL++ R
Sbjct: 4738 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR-------- 4789
Query: 2426 GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLL 2485
SL F+ AW++L +WL
Sbjct: 4790 ----------------------------------SLDDARKRAKQFHEAWSKLMEWLEES 4815
Query: 2486 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI 2545
++ + S+ + D + I + + K + L + + ++LK KTS +
Sbjct: 4816 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4875
Query: 2546 ITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEG 2605
+ D + ++++WD + R+ +L E L S Q+ +A + L + +L +
Sbjct: 4876 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4935
Query: 2606 PYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINAS 2665
+D + I K K+L + ++V A +L+ S DD+ V + + ++
Sbjct: 4936 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELSTR 4994
Query: 2666 WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERLLE 2722
W ++ ++ LE R ++F + L WL EAE T VL D R L
Sbjct: 4995 WETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLI 5054
Query: 2723 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 2782
D KE MK+ ++ + E+ T + + ++ D ++ + + ++
Sbjct: 5055 DQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRARF 5104
Query: 2783 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQKQ 2840
E+ + + L ++ L+ LL WLQ + L+ + I + V+
Sbjct: 5105 EEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKAL 5164
Query: 2841 NDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LYQE 2883
H+ F E+ K+P + +T + I + ++ G ++ LY
Sbjct: 5165 IAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPS 5224
Query: 2884 PRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2937
+ E + V L+ K W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 5225 GSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 5270
Score = 316 bits (809), Expect = 3e-85
Identities = 546/2809 (19%), Positives = 1127/2809 (40%), Gaps = 353/2809 (12%)
Query: 337 LDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 396
L+++ E WL +E L+ ++D+ + + + + D+ +H+G + I
Sbjct: 2017 LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT 2076
Query: 397 QLGSKLIGTGKLSEDEE----------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 446
G++++ K + EVQ +++ R+ L +NL ++
Sbjct: 2077 ISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVD 2136
Query: 447 DLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 504
Q+ + L L E K EP+ D ++L+RQ+++ K LQ + +QV V
Sbjct: 2137 KYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE 2196
Query: 505 SLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRWVLLQDILLKWQRLT 561
L V+ ++ G A + Q K L D R+ ++ + +R LQ L + +
Sbjct: 2197 KLKKTAEVLLDARGSLLPAKNDIQ-KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2255
Query: 562 EEQCLFSAWLSEKEDAVNK-----IHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 616
+ W+ E ++ + +++T +D + K +L+ D+ ++ S+ +
Sbjct: 2256 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQD------IISKNIMLEQDIAGRQSSINAM 2309
Query: 617 YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTT 676
+ + T + S +A + + + + K +++ A++ + T + L +
Sbjct: 2310 NEKVKKFMETT-DPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVE--LFENL 2366
Query: 677 VMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDS-----EIRKRLDVDITELHSWI 731
+ T + T+ Q L + ++P + Q +S E +K L+V LHS +
Sbjct: 2367 SEKLQTFLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHKKHLEV----LHSLL 2419
Query: 732 TR-SEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE 790
S L S + + K N S +KF++++D + +
Sbjct: 2420 KEISSHGLPSDKALVLEKTNNLS--------------KKFKEMEDTIKEKK--------- 2456
Query: 791 GVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK 850
+++ EQL++ F L+ +W++ + E + + E+ K
Sbjct: 2457 ----EAVTSCQEQLDA----FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2508
Query: 851 IQPT----TPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKG--------- 897
+Q TP S + +C + ++ ++ I +K L +G
Sbjct: 2509 LQEKWSLKTPEIQKVNNSGISLC-NLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2567
Query: 898 --QGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQ-S 954
+G + D ++ ++ + ++ + EL T L + QE SA+ W+Q+ +
Sbjct: 2568 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--QKAQEESSAMMQWLQKMN 2625
Query: 955 ETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISR 1012
+T Q TD E ++ ++ + ++ ++ L++ + + L + E+ ++ P + +
Sbjct: 2626 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2685
Query: 1013 KYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 1072
+++ EI+ +W++L+ ++ QKLEE N L + Q LK+W+ E ++ + P
Sbjct: 2686 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2745
Query: 1073 ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA--EPEFASRLETELKEL 1130
D +L Q +Q ++L+ + T +P + GQ I + +P ++ +L +
Sbjct: 2746 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2805
Query: 1131 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1190
+WD + Q+ R + + + K+ Q L + + ++ + + PD +
Sbjct: 2806 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN 2865
Query: 1191 KAVEEMKRAKEEAQQKEAKVKL---LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLC 1247
+ +E ++ K+E QQ++ ++K+ L E +++++ + A+ L ++LE + +++ +
Sbjct: 2866 QQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--LSRQLEGILKSFKDVE 2923
Query: 1248 TRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLEN 1307
+ + L+ A H+ WL+ T + + IS LD LE+
Sbjct: 2924 QKAENHVQHLQSACASSHQFQQMSRDFQAWLD-------TKKEEQNKSHPISAKLDVLES 2976
Query: 1308 LMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1367
L++ +D ++TLT M E E E + + + A++ Q
Sbjct: 2977 LIKDHKD-------FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--------- 3020
Query: 1368 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN 1427
L+ I+ + +KQ+ + K++ SLE+ K+
Sbjct: 3021 -------LNTIKTNWDTFNKQVK-------------ERENKLKE-------SLEKALKY- 3052
Query: 1428 QGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETK 1487
KE + + ID Q L+++ KF L PA E + + K + E+ H +E
Sbjct: 3053 --KEQVETLWPWIDKCQNNLEEI--KFCL--DPAEGENSIAKLKSLQKEMDQHFGMVEL- 3105
Query: 1488 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK-----KQTENPKELDERVT 1542
LN+ N S+ E+ EV V + ++QK +Q + K E +T
Sbjct: 3106 ----------LNNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHSKKFCLENMT 3153
Query: 1543 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1602
+ E+ E K+QL+ C K + + M T++ +++ +
Sbjct: 3154 QKFKEFQEVSK---ESKRQLQ-CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3209
Query: 1603 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL---VEDKLSLLNSNWIAV 1659
+D K +++ + K ++V ++T+ + TL V++K S L + +
Sbjct: 3210 VDL----AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3265
Query: 1660 TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE-DVLKRLKA 1718
+ N + E FD +D + A+TL + E K K+ + L
Sbjct: 3266 G----HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3321
Query: 1719 ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 1778
N + +T + + +L+ + D + + Q ++L R A +++ +K
Sbjct: 3322 NANKTCKMMLATEETSPDLVGIKRD--LEALSKQCNKLLDRAQAREEQVEG-----TIKR 3374
Query: 1779 LEQFNSDIQK---LLEPLEA--EIQQGVNLKEEDFNKDMN----------EDNEGTVKEL 1823
LE+F S +++ LL+ E E Q V ++ E N+ +N E +G +++
Sbjct: 3375 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3434
Query: 1824 LQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQAD 1883
G L Q + ++ + + L +QR + E +++ +
Sbjct: 3435 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3494
Query: 1884 DLLKCLDDIEKKLASLPEPRDERKI--------KEIDRELQKKKEELNAVRRQAEGLSED 1935
LL + D E+ +A+ P E K+ K + R L +K + ++R+ E +
Sbjct: 3495 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI--- 3551
Query: 1936 GAAMAVEPT-QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-ISYVP 1993
A EP ++++ K+ ++S++ LN A+ T + LE IS V
Sbjct: 3552 --ATTAEPADKVKILKQLSLLDSRWEAL--LNKAE------------TRNRQLEGISVVA 3595
Query: 1994 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 2053
+ + +++ L +E+ L + L +Q K ++D + + + H
Sbjct: 3596 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL---HQ 3652
Query: 2054 KKTAALQSATPVERVKLQEALSQLDFQ---WEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 2110
+ R S+LDF + ++ + R +++ + F D
Sbjct: 3653 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEV 3712
Query: 2111 IFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQDGIGQRQTVVRTLNATGEEIIQQ 2168
WL E L K + + +K L+ LQ+ I R+ V G E+++Q
Sbjct: 3713 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3772
Query: 2169 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD- 2227
++ + I+Q+KL ++ R++++ K +D K LE+ + E WL++ +
Sbjct: 3773 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3832
Query: 2228 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2287
+ S + K ++ + + K L +E + +L LNE +L P E L
Sbjct: 3833 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG--L 3890
Query: 2288 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2347
E + + N ++ VS + +K EI+A I + + ++ + L W++ +L
Sbjct: 3891 EKMVAEDNERYRLVSDTITQKVEEIDAAIL-------RSQQFDQAADAELSWITETEKKL 3943
Query: 2348 EIYN-----QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK---EKPATQPVKRKL 2399
Q VQ+T + D+ + L K H + Q +K+KL
Sbjct: 3944 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 4003
Query: 2400 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2459
+ + + + ++ E R Q + A +LV Q T E L
Sbjct: 4004 DKVLKNYDTICQINSE-RYLQLERAQ-------------SLVNQFWETYEELWPWLTETQ 4049
Query: 2460 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2519
S++ ++PA A L + ++ Q+ + + E+I + K + + +
Sbjct: 4050 SIISQLPAPA--------------LEYETLRQQQE---EHRQLRELIAEHKPHIDKMNKT 4092
Query: 2520 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2579
PQL EL S E +I ++ + +++E ++ R L+E + ST
Sbjct: 4093 GPQLLEL-----------SPGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQST 4140
Query: 2580 QWLEAKEEAEQVLGQARAKLESWKEGPYT---VDAIQKKITETKQLAKDLRQWQTNVDVA 2636
Q+ ++ +Q+L +E ++ P V+ I+++I+E K ++ D+ + Q +
Sbjct: 4141 QF---HDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 4197
Query: 2637 NDLALKLL-RDYSADDTRKVHMITENINAS---WRSIHKRVSEREAALEETHRLLQQFPL 2692
+++ R D + + ++ W +IH V EREA L + L ++F
Sbjct: 4198 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC 4257
Query: 2693 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD-LQGEIEAHTDVYHNL 2751
D + + + + L+D +++ + E +++ D LQ E+ D+ NL
Sbjct: 4258 DHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEEL----DIVINL 4313
Query: 2752 DENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 2811
L + G D ++++ +D +N W L K + LE + + LQ
Sbjct: 4314 GSE----LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4369
Query: 2812 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 2871
+ W+ + +L+ +PIG D V++Q + + FK E +
Sbjct: 4370 AVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAY------------------Q 4411
Query: 2872 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 2931
Q +E +E+L + L + ++ ++ E+ W+ L + Q K++ L
Sbjct: 4412 QQIE-MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4470
Query: 2932 LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 2991
L + Q A DEL L E + +PVG +++ L K L+ ++ + V V
Sbjct: 4471 LGQFQHALDELLAWLTHTEGLLSEQKPVGG-DPKAIEIELAKHHVLQNDVLAHQSTVEAV 4529
Query: 2992 NDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 3039
N L NL + LE LN RW+ + E R +QL A R
Sbjct: 4530 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4578
Score = 313 bits (803), Expect = 2e-84
Identities = 505/2706 (18%), Positives = 1066/2706 (39%), Gaps = 308/2706 (11%)
Query: 399 GSKLIGTGKLSEDEE-------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN- 450
G+ L G G + EE T +++ M ++ +E L + +K + L+ L LQ
Sbjct: 2551 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2610
Query: 451 -QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 509
++ + WL K + K ++ P D E +K QV+Q+K + +L+Q +V L
Sbjct: 2611 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2670
Query: 510 VVVVDESSGDHATAALEEQ-LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 568
+ + E + D A +Q L + +W + + T DR L++ + +
Sbjct: 2671 LTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLK 2730
Query: 569 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL- 627
WL EKE V+ + D N + + Q++ +L + +K +L + Q +LS
Sbjct: 2731 QWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2789
Query: 628 KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 687
++ S+ + L + WD+L +L I QA+ + T+
Sbjct: 2790 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS-----------------TQ 2832
Query: 688 EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFR 747
Q L++ ++L +D+++ L V T +A+ Q E A
Sbjct: 2833 YQSLLRSLSDKLSD----------LDNKLSSSLAVS--------THPDAMNQQLETAQKM 2874
Query: 748 KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK-QASEQLNS 806
K+ I++EK + + AQAL E + + V + +K + S QL
Sbjct: 2875 KQ-----------EIQQEKKQ--------IKVAQALCEDL-SALVKEEYLKAELSRQLEG 2914
Query: 807 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ-----MTTTAENWLKIQPTTPSEPTA 861
F + + N +++ + A +Q QQ+ + + T E K P + ++
Sbjct: 2915 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS-AKLDV 2973
Query: 862 IKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFS 919
++S +K KD L+ E+ + +++ LK +G L ++
Sbjct: 2974 LESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 3033
Query: 920 DVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQ 979
V+ RE +L+ + ++Y+E + + W+ + + L + + E E + +L+
Sbjct: 3034 QVKERENKLKESLEKA--LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE-GENSIAKLK 3090
Query: 980 ALQSSLQEQQSGLYYLSTT------VKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLV 1033
+LQ + + + L+ T V E+ K+ ++ ++ + + + + L
Sbjct: 3091 SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLE 3150
Query: 1034 EHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD 1093
QK +E ++ + +Q K+ ++D+ +LG K L +
Sbjct: 3151 NMTQKFKEFQEVSKESKRQLQCAKE---QLDIH-----DSLGSQAYSNKYLTMLQTQQKS 3202
Query: 1094 IQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQWDHMCQQVYARKEALKGGL 1152
+Q ++ ++ Q + EA + + S + +++ + + + QQV + L+ L
Sbjct: 3203 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3262
Query: 1153 EKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR---------AKEEA 1203
+ Q + EM + ++E + + LQK E +K A +
Sbjct: 3263 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN 3322
Query: 1204 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1263
K K+ L TE + + +K++LE L+ L R + + +E
Sbjct: 3323 ANKTCKMMLATEETSPDLV--------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3374
Query: 1264 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHS----EDNPNQI 1319
E S L++ + L + E ++ + E I++ L+ + + + +
Sbjct: 3375 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3434
Query: 1320 RILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI------QSAQE 1370
L Q L + + +L+ N+RW+ L+++ +R L++++ Q A E
Sbjct: 3435 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3494
Query: 1371 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK 1430
+ S + E L K +A KV AQ+ QE + +Q L + ++E +K+ +
Sbjct: 3495 SLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QEQKLLQRLLDDRKSTVEVIKREGEKI 3551
Query: 1431 EAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI--------LDEVKMHLP 1482
++ + K+L + ++ A R E + L+ + L
Sbjct: 3552 ATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3610
Query: 1483 ALETKSVEQEVVQSQ---LNHCVNLYKSLSEV----KSEVEMVIKTGRQIVQKKQTENPK 1535
+E + V E + +Q L + +K+L + + + G+ + E+
Sbjct: 3611 TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3670
Query: 1536 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1595
+ ++ ++ Y E+ K R + L++ L ++ ++ L WL +L+K S
Sbjct: 3671 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV 3730
Query: 1596 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNS 1654
+ L + + + Q++I +K ++ G E LK G + +++DKL + +
Sbjct: 3731 QDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3790
Query: 1655 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDV 1712
+ +T + + L + + + + W+ ++ + L E++ K ++
Sbjct: 3791 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3850
Query: 1713 L---KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI-- 1767
K LK E + + +DS + ++ L+ R+ +E ++E N R+ +S I
Sbjct: 3851 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3910
Query: 1768 KTGKASIPLKELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED- 1815
K + + +QF+ +KL+ + ++Q + K +
Sbjct: 3911 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3970
Query: 1816 --NEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISH 1873
++ + +L++ G + ++E K + +K K + ++ + + S+R +
Sbjct: 3971 LRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQS 4029
Query: 1874 QWYQYKRQADDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEEL 1922
Q+ ++L L + + ++ LP P + R+++E+ E + +++
Sbjct: 4030 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 4089
Query: 1923 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1982
N Q LS G +++ + + +I+ ++ A + + T
Sbjct: 4090 NKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDK 4145
Query: 1983 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 2042
D LE L + +S + ++++ ++ + D E L E+LK + +
Sbjct: 4146 IDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMI 4205
Query: 2043 QSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW 2102
SG D S K +Q+ L Q+ F WE ++ + ++R+ + +E
Sbjct: 4206 ARSGGTDKDISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 4252
Query: 2103 RRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTV 2154
+F D + + + F+R + P + E A+ ++E DG+ + +
Sbjct: 4253 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDI 4309
Query: 2155 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2214
V L G E+I + D I+++ + LN W + K DR +LEE ++Q
Sbjct: 4310 VINL---GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 4366
Query: 2215 DLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV 2273
L W++ A +AS+ + +K+++E++K E +Q +++LN +
Sbjct: 4367 GLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELL 4426
Query: 2274 LVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEE 2331
L EE DK +++ L + L W + + +Q ++E + LGQ + L++L
Sbjct: 4427 LKKVT---EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-- 4481
Query: 2332 QLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQ 2383
L WL+ L Q G E E+A V A Q VE + G
Sbjct: 4482 -----LAWLTHTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGN 4534
Query: 2384 HLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2441
L + + ++ KLE L+ W+ V
Sbjct: 4535 DLIESSAGEEASNLQNKLEVLNQRWQNV-------------------------------- 4562
Query: 2442 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2501
++T K ++ +L F+ +L WL+ ++ + + + + G E
Sbjct: 4563 -----LEKTEQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4613
Query: 2502 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2561
E + E + + L+ Q + + + A T I I ++ +W+ V+
Sbjct: 4614 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVE 4672
Query: 2562 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2621
L R+ +L E L + ++ + ++ L QA L +D + +I E K
Sbjct: 4673 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4732
Query: 2622 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2681
A ++ + + + L D + + ++ + W + +R+ ER +L+
Sbjct: 4733 FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLD 4792
Query: 2682 ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2741
+ + +QF K + WL E+E + + + + D +K + Q ++ Q +
Sbjct: 4793 DARKRAKQFHEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSL 4846
Query: 2742 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSD 2801
A VY + + + +DD + L L + KW + KS+ ++ LE +
Sbjct: 4847 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4906
Query: 2802 QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 2861
+ +LQ L+ WL + +L+ P+ GD V D H+AF++EL +
Sbjct: 4907 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT------ 4960
Query: 2862 LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 2921
++ L + REL E +++ + ++ Q +E++T WE + S
Sbjct: 4961 -------------SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISK 5005
Query: 2922 QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVK 2975
Q +++ L + +E L L +AE + D LID ++ ++K++
Sbjct: 5006 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 5065
Query: 2976 ALRGEI 2981
R E+
Sbjct: 5066 EKRAEL 5071
Score = 277 bits (708), Expect = 2e-73
Identities = 491/2725 (18%), Positives = 1089/2725 (39%), Gaps = 258/2725 (9%)
Query: 341 QTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGS 400
Q L+E+L W+ + E +L+ QG++ + ++D + D+ Q + + +
Sbjct: 2255 QDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2314
Query: 401 KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKELND 458
K + T S + +Q +M L++R+ E + + + ++L ++L
Sbjct: 2315 KFMETTDPST--ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2372
Query: 459 WL-TKTEERTRKMEEEPLGPDLEDLKRQVQQ-------HKVLQEDLEQEQVRVNSLTHMV 510
+L TKT+ T E + G D+ +L + +Q+ HK + LE + ++
Sbjct: 2373 FLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHK---KHLEVLHSLLKEISSHG 2426
Query: 511 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 570
+ D++ T L ++ K + D + ++ Q+ L +Q L + +W
Sbjct: 2427 LPSDKALVLEKTNNLSKKFKEMEDT----IKEKKEAVTSCQEQLDAFQVLVKS---LKSW 2479
Query: 571 LSEKEDAVNKIHTT-GFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 629
+ E V + + G +D + L +KL + +SLK + + N
Sbjct: 2480 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQ--------------EKWSLKTPEIQKVNN 2525
Query: 630 KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQ--AVTTTQPSLTQTTVMETVTTVTT- 686
++ L N + V K+ A + AV + + T T +T+
Sbjct: 2526 SGIS------LCNLI----SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2575
Query: 687 -REQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL----QSP 741
++ + H E+L K ++ ++ + + + W+ + Q+P
Sbjct: 2576 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2635
Query: 742 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 801
A E + +++ + E E + K+Q+ L+E+ + A KQ
Sbjct: 2636 --APTDTEAVKTQVEQN-KSFEAELKQNVNKVQELKDKLTELLEENPDTP-EAPRWKQML 2691
Query: 802 EQLNSRWIEFCQLLSERLNWLEYQ-NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 860
+++S+W E QL +R LE NN+ F QL+Q E + + +P
Sbjct: 2692 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2751
Query: 861 AIKSQLKICKDEVNRLSGLQPQIERLKIQSIA-LKEKGQGPMF---LDADFVAFTNHFKQ 916
+ +Q + + + + +PQ E+L L G+ P + A T +
Sbjct: 2752 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2811
Query: 917 VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 976
+ + R + + +YQ + ++ + + KLS T + M Q+L
Sbjct: 2812 LTGQLSDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLE 2869
Query: 977 ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSE-ISRKYQSEFEEIEGRWKKLSSQLVEH 1035
Q ++ +Q+++ + +++S E + + + E I +K + + H
Sbjct: 2870 TAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH 2929
Query: 1036 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1095
Q L+ + Q + + W+ + P ++L+ +K + +
Sbjct: 2930 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2989
Query: 1096 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1155
G+ + + + + L+ +L + T WD +QV R+ LK LEK
Sbjct: 2990 AQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 3049
Query: 1156 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTE 1215
+ ++ + + W+ + + E F P E + ++ ++K ++E Q V+LL
Sbjct: 3050 LKYKEQVETLWPWIDKCQNNLEEIKF-CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNN 3108
Query: 1216 SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKAN 1275
+ NS+++ + +E + E ++L + +L+ K LE + + E +++
Sbjct: 3109 TANSLLSVCE-IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESK 3167
Query: 1276 KWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI---LAQTLT----- 1327
+ L + +L +++ G ++ L L+ + + +Q+ + LAQ L
Sbjct: 3168 RQLQCAKEQLDIHDSL-GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD 3226
Query: 1328 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1387
G D L+ ++ET L ++ + LE +Q + ++ + D
Sbjct: 3227 SKGTSDVLL--QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD 3284
Query: 1388 QLAAYIADKVDAAQMPQEAQKIQSDLTSHE----------------ISLEEMKKHNQGKE 1431
+L + DA + ++ + I++ L E ++ EE G +
Sbjct: 3285 ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3344
Query: 1432 AAQRVLSQ-----IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALET 1486
LS+ +D AQ + + V + ++ F +L+E ++L + + H +
Sbjct: 3345 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE---FYSKLKEFSILLQKAEEHEESQGP 3401
Query: 1487 KSVEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTAL 1544
+E E + QLN K + ++ + + V G+ ++Q ++ + + L+ + +
Sbjct: 3402 VGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDV 3461
Query: 1545 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1604
+ L KV +R QL++ L + + + L W+ T+ + + +
Sbjct: 3462 NARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK 3521
Query: 1605 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRA 1663
+++ K Q+ ++ +K ++ I GE + T + + + +LSLL+S W A+ ++A
Sbjct: 3522 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3581
Query: 1664 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELN 1721
E L + F + ++ + +W+ + L E Q E+ + + KA +
Sbjct: 3582 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3641
Query: 1722 DIRPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL 1776
DI Q+ ++++R D + +V+ ++ F+ + + I+ + S
Sbjct: 3642 DIINHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSR 3693
Query: 1777 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRI 1834
EL Q K+ E E+ +N + +K +D EG K+ + R+
Sbjct: 3694 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRV 3747
Query: 1835 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1894
E + + KQ + Q N L+ L+ + L I + K + D+ K D+ K
Sbjct: 3748 LQE---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3804
Query: 1895 KLASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRW 1952
L + R++ EL K E+ + + + L + A+ A + +L K
Sbjct: 3805 TLEQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEA 3861
Query: 1953 REIESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 2008
+ ++ ++ A + V RE ++ ED V T ++ + A+L
Sbjct: 3862 KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAIL 3920
Query: 2009 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 2068
+Q A D + K+ SL +I+ Q+S ++ + + L+ ++ +
Sbjct: 3921 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3980
Query: 2069 -----KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ------- 2114
K+ A S+ + Q +K++K+ K+ + E++ + + NQ
Sbjct: 3981 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 4040
Query: 2115 ---WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2169
WLTE + + + P E + + ++L++ I + + + +N TG ++++ S
Sbjct: 4041 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 4100
Query: 2170 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADN 2228
SI QEK + + + ++ + + R L+E + ++F +++ + LE +
Sbjct: 4101 PGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4159
Query: 2229 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDK 2286
+ P + +++KE++ + K + ++ Q + + L + G ++ + + ++
Sbjct: 4160 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4219
Query: 2287 LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIR 2344
+++KL Q W + + E+ EA++ D+ +L +K +H L++ + +
Sbjct: 4220 VQDKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQ 4270
Query: 2345 NQLEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVK 2396
+ + P + Q+ E A + Q +++ +++ G L +P VK
Sbjct: 4271 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4330
Query: 2397 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE 2456
+ +++L+S W ++N+ ++ I KLE
Sbjct: 4331 KSIDELNSAWDSLNKAWKD-----------------------------------RIDKLE 4355
Query: 2457 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2516
+ A + + DW+ + + S + DLE + + I + K +
Sbjct: 4356 EA------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4409
Query: 2517 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2576
Q++ ++E L A+ L K + + + + D + ++ WD ++E + NR+ +L L
Sbjct: 4410 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4469
Query: 2577 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2636
Q+ A +E L L K AI+ ++ + L D+ Q+ V+
Sbjct: 4470 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4529
Query: 2637 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2696
N L+ + ++ + E +N W+++ ++ +R+ L+ R + F ++E
Sbjct: 4530 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4589
Query: 2697 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2756
WLT+ E + + L + KE + ++ EA + Y +L + Q
Sbjct: 4590 LQQWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQ 4643
Query: 2757 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2816
++L S + + + ++N+ KW + K ++ LE + + H SLQ+ + W
Sbjct: 4644 QMLARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4702
Query: 2817 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQP 2873
L + L+ + V Q D H+ F E+ + I+ +T ++ F +Q
Sbjct: 4703 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4762
Query: 2874 LEGLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQR 2923
+ ++ L + + R + V + L RK+A++ + W KL +W
Sbjct: 4763 VVLIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLE 4813
Query: 2924 KIDETLERLQELQEATDELDLKLRQ 2948
+ +++L+ E+ D++ +L Q
Sbjct: 4814 ESEKSLDSELEIANDPDKIKTQLAQ 4838
Score = 226 bits (576), Expect = 3e-58
Identities = 345/1758 (19%), Positives = 713/1758 (40%), Gaps = 172/1758 (9%)
Query: 328 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 387
+ L E+ ++ R+Q ALE +LSW++ E+ + Q S + +VVK Q + L
Sbjct: 3477 AQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD 3536
Query: 388 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 447
+ V I + G K+ T + + ++ ++ +Q++LL+SRWE L + + L + +
Sbjct: 3537 RKSTVEVIKREGEKIATTAEPA--DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3594
Query: 448 LQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 505
Q ++ L+ LN+WLT E+R + EP+G L+ Q+ QHK L++D+ + N
Sbjct: 3595 AQQFHETLEPLNEWLTTIEKRL--VNCEPIGTQASKLEEQIAQHKALEDDI----INHNK 3648
Query: 506 LTHMVVVVDES----SGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 561
H V + +S S ++ +L + I + R LLQ L +
Sbjct: 3649 HLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFG 3708
Query: 562 EEQCLFSAWLSEKEDAVNKI-----HTTGFKDQNEMLSSLQKLAVLKAD---------LE 607
E++ WL+E D ++K+ T G Q L LQ+ +L+ LE
Sbjct: 3709 EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLE 3768
Query: 608 KKKQSMGKLYSLKQDLLSTLKNK--------------------------SVTQKTEAWLD 641
KQ+ G + QD L +K + S ++ WLD
Sbjct: 3769 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3828
Query: 642 NF---ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK-HAQE 697
++ V K E+++ + + + +++++ V++ LV A+E
Sbjct: 3829 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRARE 3888
Query: 698 ELPP--PPPQKKRQITVDSEIRKRLDVDITELH------------SWITRSEAVLQSPEF 743
L ++ ++ D+ +K ++D L SWIT +E L S
Sbjct: 3889 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3948
Query: 744 AIFRKEGNFSDLK-EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE 802
++ + L+ +K +E + + + D +S ++ E S+K+ +
Sbjct: 3949 IRLEQDQTSAQLQVQKTFTMEILRHKDI--IDDLVKSGHKIMTACSEE--EKQSMKKKLD 4004
Query: 803 QLNSRWIEFCQLLSERLNWLEYQNNII-AFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 861
++ + CQ+ SER LE +++ F+ ++L T ++ + P E
Sbjct: 4005 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 4064
Query: 862 IKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMF-LDADFVAFTNHFKQVFSD 920
++ Q + + ++ +P I+++ L E G F + +VA + Q+ D
Sbjct: 4065 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 4124
Query: 921 VQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQA 980
V+ R L ++ + + I +++ +L P + E +++++ E +
Sbjct: 4125 VKKRAVALDEAIS--QSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4182
Query: 981 LQSSLQEQQSGLYYLSTTVKEM---SKKAPSEISRK-YQSEFEEIEGRWKKLSSQLVEHC 1036
+ +++ Q L +EM S +IS K Q + +++ W+ + + + E
Sbjct: 4183 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4242
Query: 1037 QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKE-EWPALGDSEILKKQLKQCRLLVSDIQ 1095
KL + M K +L + + F+++ E P + D ++K+Q + + +I
Sbjct: 4243 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI-DPSVVKQQQEAAETIREEID 4301
Query: 1096 TIQPSLNSV-NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1154
+Q L+ V N G + I EP+ ++ + ELN+ WD + + R + L+ ++
Sbjct: 4302 GLQEELDIVINLGSELIAACGEPD-KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4360
Query: 1155 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1214
V Q L + +W+ A + + +++ +EE+K+ K EA Q++ +++ L
Sbjct: 4361 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4420
Query: 1215 ESVNSVIAQAPPVA-QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEK 1273
++ + + + ++ L L + L R+ + LE + L++
Sbjct: 4421 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4480
Query: 1274 ANKWLNEVEFKLKTTENIPGGAEEISEVLDS---LENLMRHSEDNPNQIRILAQTLTDGG 1330
WL E L + + G + I L L+N + + + L +
Sbjct: 4481 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4540
Query: 1331 VMDELIN--EELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1388
+E N +LE N RW+ + E+ +R++ L+ +++ A+ + +Q+ LT ++
Sbjct: 4541 AGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERH 4600
Query: 1389 LAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEE-----MKKHNQ-----GKEAAQR 1435
L A +P+ A++ + ++ + + EE M+K Q K A
Sbjct: 4601 LLA----SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4656
Query: 1436 VLSQIDVAQKKLQDVSMKF--------RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1487
+ I+ ++K + V K F LQ+ L + + L
Sbjct: 4657 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4716
Query: 1488 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLH 1547
S+ + V Q++ ++ + ++ + KTG + Q ++ + + +++
Sbjct: 4717 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4776
Query: 1548 YNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEV 1607
+ ++ ++ ER + L+ K +++ + + L EWL ++ L + P + +++
Sbjct: 4777 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4836
Query: 1608 AWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1665
A K QK + + + G +L KT L ++D LS L W + ++ E
Sbjct: 4837 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4896
Query: 1666 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK-----KKPQQKEDVLKRLKAEL 1720
N L E F + + W+ + + L E + D K + EL
Sbjct: 4897 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4956
Query: 1721 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS--HRIKTGKASIPLKE 1778
V + + A L+ D V+ Q+ EL+ R+ + K + L++
Sbjct: 4957 GKRTSSVQALKRSARELIEGSRDD-SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 5015
Query: 1779 LEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1833
E+F+S + LLE L AE +Q GV +ED + + + ++ +K+L ++ L +
Sbjct: 5016 AEEFHSVVHALLEWL-AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKA 5074
Query: 1834 IT------------------------DERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1869
T R E + +Q Q +AL L + +++ L
Sbjct: 5075 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIA--KQELL 5132
Query: 1870 EISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1929
E W Q+ L D +K++ P++ ++K + E Q EE+ +
Sbjct: 5133 EALLAWLQWAETT------LTDKDKEVI----PQEIEEVKALIAEHQTFMEEMTRKQPDV 5182
Query: 1930 EGLSEDGAAMAVEPTQIQ 1947
+ +++ A +P+ +Q
Sbjct: 5183 DKVTKTYKRRAADPSSLQ 5200
Score = 221 bits (564), Expect = 8e-57
Identities = 112/232 (48%), Positives = 154/232 (66%), Gaps = 5/232 (2%)
Query: 6 SDEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGST 65
+DER+ VQKKTFTKW+N K K H+ +L+ DL+DG L+ LLE L+G LP+EKG
Sbjct: 208 ADERDKVQKKTFTKWINQHLMKVRK-HVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRM 266
Query: 66 RVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMA 125
R H L NV AL L+ V LVNI + DI DGN KLTLGLIW IILH+Q+ ++ ++
Sbjct: 267 RFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDI--HVTG 324
Query: 126 GLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQ 185
+ ++++ LL W +Q+T Y + NFTT W DG NA+IH +RPDL D N+V
Sbjct: 325 ESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV- 383
Query: 186 QSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 237
QS LEHAF +A ++G+ +LLDPEDVD + PD+KS++ Y++SL+ P+
Sbjct: 384 QSNLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK 434
Score = 205 bits (521), Expect = 8e-52
Identities = 284/1564 (18%), Positives = 642/1564 (41%), Gaps = 148/1564 (9%)
Query: 264 LHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA-YTQAAYVTTSDPTRSPFPSQHLEAPE 322
++H H Q +++ + + K +S ++Q Y+ + + S
Sbjct: 3644 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCN 3703
Query: 323 DKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYM 382
K FG E EV L + + + LS L + + + + +++ V+++
Sbjct: 3704 AKIFG----EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE--------- 3750
Query: 383 MDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH 442
D+ + V L G +L+ + + DE +Q+++ + +R++ + S + L
Sbjct: 3751 -DILLRKQNVDQALLNGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLE 3807
Query: 443 RVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQ 500
+ L + + +EL WL K E E + L E+ + + K L+++ + +
Sbjct: 3808 QALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG--EEASQAQMRPKELKKEAKNNK 3865
Query: 501 VRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRL 560
++SL + + E A LE+ + +R+ + + + +L+ Q+
Sbjct: 3866 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3925
Query: 561 TEEQCLFSAWLSEKEDA-------------------VNKIHTTGFKDQNEMLSSLQKLA- 600
+ +W++E E V K T +++ L K
Sbjct: 3926 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3985
Query: 601 -VLKADLEKKKQSMGKLYS--LKQ-DLLSTLKNKSVTQ--KTEAWLDNFARCWDNLVQKL 654
++ A E++KQSM K LK D + + ++ Q + ++ ++ F ++ L L
Sbjct: 3986 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 4045
Query: 655 EKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ--EELPPPPPQ------- 705
++ + ISQ P+L T+ + +++ +H +++ PQ
Sbjct: 4046 TETQSIISQLPA---PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 4102
Query: 706 -----KKRQITVDS-------EIRKR---LDVDITELHSWITRSEAVLQSPEFAIFRKE- 749
+++ + D+ +++KR LD I++ + + + +L+S E + R
Sbjct: 4103 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4162
Query: 750 -----GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMV------NEGVNADSIK 798
+KE+++ + + KLQ + + E+M+ ++ ++A +++
Sbjct: 4163 PPSISAEVEKIKEQISENKNVSVD-MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4221
Query: 799 QASEQLNSRWIEFCQLLSER-LNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 857
+Q+ W L+ ER L+ F+ L +++++
Sbjct: 4222 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4281
Query: 858 EPTAIKSQLKICKDEVNRLSGLQPQIE---RLKIQSIALKEKGQGPMF---LDADFVAFT 911
+P+ +K Q + + + GLQ +++ L + IA + P+ +D A+
Sbjct: 4282 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4341
Query: 912 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 971
+ K + E+ +Q ++YQ+ + A+ WV + KL+ TD E +
Sbjct: 4342 SLNKAWKDRIDKLEEAMQAA------VQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 4395
Query: 972 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEFEEIEGRWKKLSS 1030
+Q++ EL+ +S +QQ + L+ + + KK E + Q E++ W L
Sbjct: 4396 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 4455
Query: 1031 QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 1090
+++ KLE + L + Q+ + L W+ + L E+ P GD + ++ +L + +L
Sbjct: 4456 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4515
Query: 1091 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1150
+D+ Q ++ +VN+ G + + E AS L+ +L+ LN +W ++ ++ RK+ L G
Sbjct: 4516 QNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDG 4575
Query: 1151 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKV 1210
L + ++ ++ +W+T E L P+ ++ + + KE
Sbjct: 4576 ALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4635
Query: 1211 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1270
K L + ++A+ P A+ + +++ L ++ + T+LN + LEE E +
Sbjct: 4636 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4695
Query: 1271 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1330
L+ WL + E L + + +D + + QI L +T T
Sbjct: 4696 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4755
Query: 1331 VMDE-----LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI 1385
+ LI L + SRW ++ + V R + L+ + + A++ ++ + E L
Sbjct: 4756 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4815
Query: 1386 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQK 1445
+K L + + ++ + KI++ L H +E +K K + ++ + K
Sbjct: 4816 EKSLDSEL-------EIANDPDKIKTQLAQH----KEFQKSLGAKHSVYDTTNRTGRSLK 4864
Query: 1446 ----------KLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPAL------ 1484
KL D+ + R + K + +L+E+ + + L AL
Sbjct: 4865 EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYR 4924
Query: 1485 -ETKSVEQEVVQSQLNHCVNL-------YKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1536
E + E + V ++ +NL K L + S V+ + ++ R++++ + ++
Sbjct: 4925 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR-DDSSW 4983
Query: 1537 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1596
+ ++ L + + A ++ +LE L+ + + ++ L EWLA + L +
Sbjct: 4984 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 5043
Query: 1597 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDKLSLLNSN 1655
L + + K K++E+++ L T +G+ + + T ++ ++++ +
Sbjct: 5044 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 5103
Query: 1656 WIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR 1715
+ V + A++ L + + ++ + W+ A+T L + +K+ Q+ + +K
Sbjct: 5104 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5163
Query: 1716 LKAE 1719
L AE
Sbjct: 5164 LIAE 5167
Score = 178 bits (452), Expect = 8e-44
Identities = 527/2759 (19%), Positives = 1063/2759 (38%), Gaps = 415/2759 (15%)
Query: 452 KLKELNDWLTKTEE--------RTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 503
KLK +N L T+ T+ EEE + D +++ + K + ++++++
Sbjct: 1348 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 1407
Query: 504 NSLTHMV----VVVDESSGDHATAALE-----EQLKVLGDRWANICRWTEDRWVLLQDI- 553
++L + + DE + L+ E+ L +RW N+ ++R L+ I
Sbjct: 1408 HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 1467
Query: 554 -LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQS 612
LK+ R T W+ + E KI ++ + + L + +L +++E K+
Sbjct: 1468 KSLKYYRDTYHP--LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1525
Query: 613 MGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 672
M + + +T+K+ + T + D+ + K S A Q +
Sbjct: 1526 MDECQKYAEQYSATVKDYELQTMT------YRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1579
Query: 673 TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWIT 732
T + T+ T+ +K A + L ++K +++ E ++ ++ EL W++
Sbjct: 1580 DLRTRYTALVTLMTQ---YIKFAGDSLKRLEEEEK---SLEEEKKEHVE-KAKELQKWVS 1632
Query: 733 RSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV 792
L+ E K G K+K+++ E + K +L +A ++ Q + + +
Sbjct: 1633 NISKTLKDAE-----KAGKPPFSKQKISS--EEISTKKEQLSEALQTIQLFLAKHGD--- 1682
Query: 793 NADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ 852
K E+ N L +++ L+ N++ F L+QL++ T+ + +K+
Sbjct: 1683 -----KMTDEERNE--------LEKQVKTLQESYNLL-FSESLKQLQESQTSGD--VKV- 1725
Query: 853 PTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN 912
E + + + K+++ + L Q E I G F+ D
Sbjct: 1726 -----EEKIVAERQQEYKEKLQGICDLLTQTENRLI--------GHQEAFMIGDGTVELK 1772
Query: 913 HFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET--KLSIPQLSVTDYEI 970
+ Q++++ELQ Q + A+ V+ +E K + +LS D +
Sbjct: 1773 KY-------QSKQEELQKDM--------QGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1817
Query: 971 MEQRLGE--LQALQSSLQEQQSGLYY---LSTTVKEMSKKAPS-----EISRKYQSEFEE 1020
+EQ+L E ++ Q +L+ +QS ++T +KE ++K + E K ++ +
Sbjct: 1818 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1877
Query: 1021 IEGRWKKLSSQLVEHCQKLEE-----QMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 1075
+ K +H Q +E+ Q + + + E DV +
Sbjct: 1878 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1937
Query: 1076 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD 1135
++ +K Q ++S Q + + S +K PE +L+ +KEL ++
Sbjct: 1938 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYE 1997
Query: 1136 HMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEE 1195
+ + + E+ D +E W+ Q+E+E + + L ++
Sbjct: 1998 TALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR 2057
Query: 1196 MKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ------------EALKKELETLTTNY 1243
K E+ + ++ +T S N V+ A ++ ++++L+ T +
Sbjct: 2058 QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRF 2117
Query: 1244 QWL---CTRLNGKCKTLEEVWACWHE----LLSYLE----KANKWLNE--------VEFK 1284
+ L C L K L + + + + LL+ L+ A+K L+E ++ +
Sbjct: 2118 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 2177
Query: 1285 LKTTENIPG----------------------------GAEEISEVLDSL----ENLMRHS 1312
L+ T+ + G +I + LD + E+L +
Sbjct: 2178 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSV 2237
Query: 1313 EDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEA------------VRRQKL 1360
+ +++I TLT + + ++E L+ + L E+ + + +
Sbjct: 2238 NERNEKLQI---TLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIM 2294
Query: 1361 LEQSIQSAQETEKSLH-LIQESLTFIDKQLAAYIADKVD--AAQMPQEAQKIQSDL---- 1413
LEQ I Q + +++ +++ + D A+ + K+ +A+ + + K + L
Sbjct: 2295 LEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKME 2354
Query: 1414 ---TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 1470
T E+ +K E + L+++DV K + ++S Q +QES
Sbjct: 2355 ELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELS-------------QYMQES 2401
Query: 1471 KMILDEVKMHLPALET--KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK 1528
E K HL L + K + + S + +LS+ E+E IK ++ V
Sbjct: 2402 TSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTS 2461
Query: 1529 KQTENP-------------KELDERVTALKLHY--NELGAKVTERKQQLEKCLKLSRKMR 1573
Q + KE ++V ++ + +LG + + K+ EK + +++
Sbjct: 2462 CQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ 2521
Query: 1574 KEMN---VLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEV 1630
K N L ++A +AV+ + L+ E G AT E L SI +
Sbjct: 2522 KVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE---GTATNTEEFWANKGLTSIKKD 2578
Query: 1631 GEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 1690
+ L++DK++ LN+ + EE ++ QK +T TKW
Sbjct: 2579 MTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT-------ATKW 2631
Query: 1691 IIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLM--------ANRG 1742
Q ++E K Q +++ K +AEL KV +D+ L+ A R
Sbjct: 2632 --QQTPAPTDTEAVKTQVEQN--KSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRW 2687
Query: 1743 DHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVN 1802
++ + ELN I + K ++S L + + + +++ L +E E+ V
Sbjct: 2688 KQMLTEIDSKWQELNQ--LTIDRQQKLEESSNNLTQFQTVEAQLKQWL--VEKELMVSV- 2742
Query: 1803 LKEEDFNKDMNEDNEGTVKELLQR--------------GDNLQQRITDERKREEIKIKQQ 1848
L + +M V+ LLQ G + R ++ I +K+Q
Sbjct: 2743 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGI-VKEQ 2801
Query: 1849 L--LQTKHNALKDLRSQR---RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1903
L + K ++L S R +A+ S Q+ R D L LD+ K +SL
Sbjct: 2802 LAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN--KLSSSLAVST 2859
Query: 1904 DERKIKEIDRELQKKKEELNAVRRQ---AEGLSEDGAAMAVEP-TQIQLSKRWREIESKF 1959
+ + QK K+E+ ++Q A+ L ED +A+ E + +LS R++E
Sbjct: 2860 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELS---RQLEGIL 2916
Query: 1960 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV---EQLLNA 2016
F+ + + V+ L+ + S +++ QA L+ EQ +
Sbjct: 2917 KSFKDVEQKAENHVQH-----------LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2965
Query: 2017 PDLCAKD-FEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALS 2075
P D E L K K+ +L S + ++ L E+ LQ L+
Sbjct: 2966 PISAKLDVLESLIKDH---KDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLN 3022
Query: 2076 QLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQI---PENW 2132
+ W+ NK K+R+ + S+EK ++ ++ W+ + + L + + P
Sbjct: 3023 TIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG 3082
Query: 2133 EHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC 2192
E++ K LK LQ + Q +V LN T ++ + D ++ ++ SL + V
Sbjct: 3083 ENSIAK--LKSLQKEMDQHFGMVELLNNTANSLL-SVCEIDKEVVTDENKSLIQKVDMVT 3139
Query: 2193 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-------DNIAS----------IPLE 2235
+QL +K LE EFQ E L+ A D++ S + +
Sbjct: 3140 EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3199
Query: 2236 PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLK--- 2292
Q LK +++ K L ++L + K ++ VL+ +E L ++
Sbjct: 3200 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSD----VLLQVETIAQEHSTLSQQVDEKC 3255
Query: 2293 ---QTNLQWI----KVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRN 2345
+T LQ I R + + E + ++ + + + E L++Q + +L +
Sbjct: 3256 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEA 3315
Query: 2346 QLEIYNQPNQEGPFDVQETEIA-----------------------VQAKQPDVEEILSKG 2382
+ + N+ + E + QA++ VE + +
Sbjct: 3316 LMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRL 3375
Query: 2383 QHLYKEKPATQPVKRKLED-------LSSEWKAVNRLL-----------QELRAKQPD-- 2422
+ Y + + +K E+ + E + +N+ L + L+ KQ D
Sbjct: 3376 EEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVN 3435
Query: 2423 -LAPGLTTIGASPTQTVTLV--TQPVVTKETAISKLEMPSSLMLEVPAL--ADFNRAWTE 2477
L GL A T T L V + ++K + L+ L F A
Sbjct: 3436 WLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALES 3495
Query: 2478 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 2537
L W+ ++++ +Q+ + + + I +QK + L+ R+ +E + + + T
Sbjct: 3496 LLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAT-T 3554
Query: 2538 SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 2597
+ + I ++ + ++W+ + + R +QL + + Q+ E E + L
Sbjct: 3555 AEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEK 3614
Query: 2598 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHM 2657
+L + + ++++I + K L D+ ++ A + L S +D V
Sbjct: 3615 RLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQS 3674
Query: 2658 ITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRK 2717
+ + I ++ R L++ + F D + + WL E +
Sbjct: 3675 KLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH---------DKL 3725
Query: 2718 ERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDE---NSQKILRSLEGSDDAVLLQRR 2774
+L + L KQ +L+ E N+D+ N ++L+ G D+ +++Q +
Sbjct: 3726 SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTG-DEVLIIQDK 3784
Query: 2775 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDE-LSRQAPIGGD 2833
L+ + ++ ++ K S ++ LE + +RLH + +EL WL + E LS + +
Sbjct: 3785 LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG 3844
Query: 2834 FPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQP---LEGLEKLYQEPRELPPE 2890
A Q Q + K+E K + ++ S E L P EGLEK+ E
Sbjct: 3845 EEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAE-----DN 3898
Query: 2891 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-DLKLRQ 2948
ER + V+ + ++ EE+ + L S + + D L + E ++ L D++L Q
Sbjct: 3899 ERYRLVSDTITQKVEEI----DAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3953
Score = 38.9 bits (89), Expect = 0.095
Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 27/168 (16%)
Query: 2810 LQELLVWLQLKDDELSRQAPIGGDFPAVQKQ----NDVHRAFKR-ELKTKEPVIMSTLET 2864
+Q+LL W+ +L R G D P+V+ +VHRA + E KE I T
Sbjct: 786 VQDLLNWVDEMQVQLDR-TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 844
Query: 2865 VRIFLT-EQPLEGLEKLY--------QEPRELPP----EERAQN-VTRLLRKQAEEVNTE 2910
+ LT + L LE Y + R L RA N + L K+ EEV +
Sbjct: 845 APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYD 904
Query: 2911 WEKLNL-------HSADWQRKIDETLERLQELQEATDELDLKLRQAEV 2951
W + N + A+ R++D+ E ++ +QE ++L L+ A +
Sbjct: 905 WSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 952
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 325 bits (832), Expect = 7e-88
Identities = 545/2835 (19%), Positives = 1126/2835 (39%), Gaps = 316/2835 (11%)
Query: 338 DRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQ 397
++ QT LE L + + E+S ++ +F H+ ++ +L
Sbjct: 2190 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-----------EVLH 2238
Query: 398 LGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKE 455
K I + L D+ V E+ N L+ +++ + EK+ + + +D +K
Sbjct: 2239 SLLKEISSHGLPSDKAL-VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2297
Query: 456 LNDWLTKTEERTRKMEE----EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 511
L W+ +T ++ ++ E LG LED K+ ++ + ++++ SL +++
Sbjct: 2298 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2357
Query: 512 VVDESSGDHATAALEEQLKVLGDR---------WAN------------ICRWTEDRWVLL 550
V + A AA++ VL WAN I ED +LL
Sbjct: 2358 AVTTPA--KAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2415
Query: 551 QDI-------LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS-LQKLAVL 602
+D L K Q+ EE WL + K T E + + +++
Sbjct: 2416 KDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSF 2475
Query: 603 KADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS 662
+A+L KQ++ K+ LK L L+ T + W D+ Q+L + T
Sbjct: 2476 EAEL---KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEI-DSKWQELNQLTIDRQ 2531
Query: 663 QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV 722
Q + + +LTQ +E
Sbjct: 2532 QKLEESSNNLTQFQTVEA------------------------------------------ 2549
Query: 723 DITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 782
+L W+ E ++ S + + +++V + +E A + + + + + Q
Sbjct: 2550 ---QLKQWLVEKELMV-SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2605
Query: 783 LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQN-NIIAFYNQLQQLEQM 841
++ + + +K+ + +W LS+R +W++ + + L+ L
Sbjct: 2606 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2665
Query: 842 TTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQ----SIALKEKG 897
+ +N L + P A+ QL+ + + + QI+ + S +KE+
Sbjct: 2666 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE- 2724
Query: 898 QGPMFLDADFVAFTNHFKQVFSDVQAR-EKELQTIFDTLPPM-RYQETMSAIRTWVQQSE 955
+L A+ + F DV+ + E +Q + ++Q+ + W+ +
Sbjct: 2725 ----YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2780
Query: 956 TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 1015
+ + +++E + + + +L Q + + K Q
Sbjct: 2781 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2840
Query: 1016 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW---- 1071
+ I+ W + Q+ E KL+E + K K + ++TL W+ + L+E
Sbjct: 2841 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2900
Query: 1072 PALGDSEI-----LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE 1126
PA G++ I L+K++ Q +V + SL SV E +++ + E
Sbjct: 2901 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-----------E 2949
Query: 1127 LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD------ 1180
K L + D + +Q++++K L+ +K Q+ E + A+E+ D
Sbjct: 2950 NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA 3009
Query: 1181 FEYKTPDELQKAVEEMKRAKEEAQ-QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETL 1239
+ K LQ + ++ K + K L+ E+ +S + E + +E TL
Sbjct: 3010 YSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL 3069
Query: 1240 TTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEIS 1299
+ C+ L K + + E+ S + + L+ + + E + E I
Sbjct: 3070 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIK 3129
Query: 1300 EVLDSLENLMRHSEDNPNQI--RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRR 1357
L LE LM S DN N+ +LA T ++ I +LE + + +L + A R
Sbjct: 3130 AFLKKLEALMA-SNDNANKTCKMMLATEETSPDLVG--IKRDLEALSKQCNKLLDRAQAR 3186
Query: 1358 QKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMP--QEAQKIQSDLTS 1415
++ +E +I+ +E L +E + K A++ + +Q P E + I L
Sbjct: 3187 EEQVEGTIKRLEEFYSKL---KEFSILLQK------AEEHEESQGPVGMETETINQQLNM 3237
Query: 1416 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 1463
++ +E + QGK+ L Q I A K L DV+ +++ L +K A
Sbjct: 3238 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3297
Query: 1464 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 1509
+LQE+ + + L +L + S E +VV++Q+ L + L
Sbjct: 3298 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3357
Query: 1510 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 1569
+ KS VE++ + G +I + + ++ ++++ L + L K R +QLE ++
Sbjct: 3358 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3417
Query: 1570 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 1629
++ + + L EWL + L + S L+ ++A KA + +I HL
Sbjct: 3418 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3477
Query: 1630 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1688
+G++LK + +++ +V+ KL +I + ++ LL + + + F ++ +
Sbjct: 3478 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3537
Query: 1689 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 1748
W+ + L S+ + L + ++EL ++ + + + N + ++
Sbjct: 3538 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3595
Query: 1749 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 1796
++ + + AI R K T ++ K LEQ ++L L+ +E E
Sbjct: 3596 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3655
Query: 1797 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 1846
+ + LK E+ + K++ ++ N + + L + + R RE ++
Sbjct: 3656 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3715
Query: 1847 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1906
++ + D +Q+ ++ + Q+ + AD L + + EKKL SL + R E+
Sbjct: 3716 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3775
Query: 1907 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1966
+ +LQ +K + R + + D + S+ ++ K N
Sbjct: 3776 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3831
Query: 1967 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 2026
+ I + E + + L ++ TY + L E + +++ A ++E
Sbjct: 3832 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 3886
Query: 2027 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2086
L +Q+E + +++ + + ID ++ K L +P E +QE D + ++ +
Sbjct: 3887 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3945
Query: 2087 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 2144
K R D ++ + +FH I +Q L E+ + + + P + E K K + E
Sbjct: 3946 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 4002
Query: 2145 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 2197
++ + + Q + TL GEE+I +S TD I +Q+KL + W+ + + +
Sbjct: 4003 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4062
Query: 2198 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 2256
R+ +L + + +F D ++ +++ + +PG + + K++ E + + EE+
Sbjct: 4063 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4122
Query: 2257 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 2314
Q L + G ++ + E DK ++ + + N W +++A ++ ++E
Sbjct: 4123 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 4178
Query: 2315 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2371
++ Q + L+ D + L +SPI LE Q +E +++ + +
Sbjct: 4179 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 4234
Query: 2372 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 2431
Q ++E + + + L K K + K ++D E K + L+E
Sbjct: 4235 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 4278
Query: 2432 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 2491
++ ++ KLE +L+ AL F A EL WL+ + ++
Sbjct: 4279 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 4316
Query: 2492 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2551
Q+ + GD + I + K D+ + +E + A +L ++ +EA + +++E
Sbjct: 4317 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4375
Query: 2552 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2611
+ +W V E + R+QQL+ L+ + + E+ +Q L L + K +
Sbjct: 4376 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4435
Query: 2612 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2671
++++ ++ + ++L + N+ W S+
Sbjct: 4436 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4495
Query: 2672 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 2731
+++ER+ LEE L +F L+ F+ WLT+AE T NV A+R +L+ V +
Sbjct: 4496 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4549
Query: 2732 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 2791
+ + E+ +H + LD+ L+ D VL++ L ++ +W ++ ++ +
Sbjct: 4550 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4608
Query: 2792 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 2851
L+ + + K+ H + +L+ WL+ + L + I D ++ Q H+ F++ L
Sbjct: 4609 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4668
Query: 2852 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 2911
K V +T T R L + + L E+ +W
Sbjct: 4669 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4709
Query: 2912 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 2970
+ + S + Q K++E L + +A L L + E QPV GD ID + +
Sbjct: 4710 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4767
Query: 2971 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 3023
++ KA + E+ +V + AR+L S + +++L+TRW+ +
Sbjct: 4768 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4827
Query: 3024 QVAVEDRVRQLHEAH 3038
Q +E +RQ E H
Sbjct: 4828 QTRLEAALRQAEEFH 4842
Score = 325 bits (832), Expect = 7e-88
Identities = 536/2814 (19%), Positives = 1113/2814 (39%), Gaps = 346/2814 (12%)
Query: 330 LMESEVNLDRYQTALEE---VLSWL--LSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD 384
+ E L + Q A EE ++ WL ++ T Q D E VK Q ++ + +
Sbjct: 2419 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2478
Query: 385 LTAHQGRVGNILQLGSKLIGTGKLSEDEETEV----QEQMNLLNSRWECLRVASMEKQSN 440
L + V + +L KL T L E+ +T ++ + ++S+W+ L ++++Q
Sbjct: 2479 LKQN---VNKVQELKDKL--TELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2533
Query: 441 LHRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQ 498
L +L + E L WL + E + PL D L Q QQ ++L ++
Sbjct: 2534 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLG--PLSIDPNMLNTQRQQVQILLQEFAT 2591
Query: 499 EQVRVNSLTHMVVVVDESSGDHAT--AALEEQLKVLGDRWANICRWTEDRWVLLQDILLK 556
+ + LT + G+ + ++EQL + +W ++ DR + ++K
Sbjct: 2592 RKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVK 2651
Query: 557 WQRLTEEQCLFSAWLSEKEDAVNKIHT-----TGFKDQNEMLSSLQKLAVLKADLEKKKQ 611
T+ Q L + + D NK+ + T N+ L + QK+ K +++++K+
Sbjct: 2652 ---STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKM---KQEIQQEKK 2705
Query: 612 SMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ-- 669
+ +L +DL + +K + + + L+ + + ++ QK E + A ++
Sbjct: 2706 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2765
Query: 670 ----------------------PSLTQTTVMETVT-------------------TVTTRE 688
P + V+E++ T+ E
Sbjct: 2766 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2825
Query: 689 QILVKHAQEELPPPPPQ---------------KKRQITVDSEIRKRLDV--DITELHSWI 731
+L+K E Q K+R+ + + K L + L WI
Sbjct: 2826 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 2885
Query: 732 TRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV------- 784
+ + L+ +F + EG S K K ++++E + F ++ + +A +L+
Sbjct: 2886 DKCQNNLEEIKFCLDPAEGENSIAKLK--SLQKEMDQHFGMVELLNNTANSLLSVCEIDK 2943
Query: 785 EQMVNEGVNA-DSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 843
E + +E + + +EQL+S+ +FC L + + E+Q QLQ ++
Sbjct: 2944 EVVTDENKSLIQKVDMVTEQLHSK--KFC-LENMTQKFKEFQEVSKESKRQLQCAKEQLD 3000
Query: 844 TAEN---------WLKIQPTTPSEPTAIKSQLKICKDEVNRL----------SGLQPQIE 884
++ +L + T A+K Q+ + K L S + Q+E
Sbjct: 3001 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE 3060
Query: 885 RLKIQSIALKEK-GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPM-RYQE 942
+ + L ++ + FL+ HF+ ++ ++ E D++ P+ R E
Sbjct: 3061 TIAQEHSTLSQQVDEKCSFLETKLQGI-GHFQNTIREMFSQFAEFDDELDSMAPVGRDAE 3119
Query: 943 TMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEM 1002
T+ + ++ KL S + + + +E L + ++ +
Sbjct: 3120 TLQKQKETIKAFLKKLEALMAS-------NDNANKTCKMMLATEETSPDLVGIKRDLEAL 3172
Query: 1003 SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1062
SK+ + R Q+ E++EG K+L E KL+E L+K + H ++
Sbjct: 3173 SKQCNKLLDRA-QAREEQVEGTIKRLE----EFYSKLKEFSILLQKAEEHEES------- 3220
Query: 1063 VDVFLKEEWPALGDSEILKKQLKQCRLLVSD-IQTIQPSLNSVNEGGQK-IKNEAEPEFA 1120
+ P ++E + +QL ++ + I+ +Q VN GQ I++ A+
Sbjct: 3221 -------QGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTST 3273
Query: 1121 SRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD 1180
LE +L ++N +W + ++V R L+ L Q L + WM EE +
Sbjct: 3274 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3333
Query: 1181 FEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLT 1240
++ ++E K + +++ V+++ + A P + + K+L L
Sbjct: 3334 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3393
Query: 1241 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1300
+ ++ L + + + LE + + LE N+WL +E +L E I A ++ E
Sbjct: 3394 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3453
Query: 1301 VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELET-------FNSRWR-ELHE 1352
+ + L +D N + L Q ++ G + L + E + F+ W E+ E
Sbjct: 3454 QIAQHKAL---EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3510
Query: 1353 EAVRRQKLLEQSIQSAQET-EKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK--I 1409
++ R +LL+Q++ +A+ E + L+ DK + D Q+++ +
Sbjct: 3511 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3570
Query: 1410 QSDLTSHEISLEEMKKHNQGKEAAQRVLS-QIDVAQKKLQDVSMKFRLFQKPAN-----F 1463
Q D+ + ++++ + G E ++ ++ + Q KL+ + +++ K +
Sbjct: 3571 QEDILLRKQNVDQALLN--GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3628
Query: 1464 EQRLQESKMI----------LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1513
EQ LQ ++ + LD+V++ L + ET+ ++ E L K K+
Sbjct: 3629 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKA 3688
Query: 1514 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1573
++ + + +++ + L++ V Y + +T++ ++++ + S++
Sbjct: 3689 LLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFD 3748
Query: 1574 KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEA 1633
+ + W+ T+ +L + +++ K EI + K + + + G
Sbjct: 3749 QAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHK 3808
Query: 1634 LKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWII 1692
+ T ++E ++ KL + N+ + E L Q + F + + + W+
Sbjct: 3809 IMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT 3868
Query: 1693 QADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRGDH 1744
+ +++ E E + QQ+E L+ L AE K++ T Q L G
Sbjct: 3869 ETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS 3928
Query: 1745 CRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ--- 1799
++ + + ++ I +K ++ + + QF+ I ++LE LE +++
Sbjct: 3929 ----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 3984
Query: 1800 --GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIKQQ 1848
++ + E + ++E+ +V + L QRG+ + R K K Q
Sbjct: 3985 PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 4044
Query: 1849 LLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-D 1904
L + L +R K L++ ++ L+ + D + + L +P D
Sbjct: 4045 KLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4104
Query: 1905 ERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKFAQ 1961
+K+ + +EE++ ++ + + L + A EP + + K E+ S +
Sbjct: 4105 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDS 4164
Query: 1962 FRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCA 2021
+ +I + EE M + Y + V + L +
Sbjct: 4165 LNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSPIG 4211
Query: 2022 KDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLDFQ 2080
D E + +Q E LK K Q ++ ++ + L+ T ++ +Q+ L +L
Sbjct: 4212 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 4271
Query: 2081 WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 2140
W+ + + +RQ + + ++ +F + + WLT E L + Q P + +
Sbjct: 4272 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIEIE 4330
Query: 2141 LKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSD 2197
L + LQ+ + Q+ V +N G ++I+ S+ +AS LQ KL LN RWQ V ++
Sbjct: 4331 LAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQ 4390
Query: 2198 RKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLVEE 2255
RK++L+ F ++ + WL + + +AS PL G + KE+L +
Sbjct: 4391 RKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVCAA 4449
Query: 2256 LPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEIEA 2314
++ K L + G +L P S E D+ N LK+ +W V L E++ ++E
Sbjct: 4450 FEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKLEE 4506
Query: 2315 QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---AV 2368
+ + L+D + WL+ L + ++P+ F + E ++ V
Sbjct: 4507 ALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4559
Query: 2369 QAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDLAP 2425
+ + + E+ G HL + +K +K L + S W K V RL++ R
Sbjct: 4560 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR-------- 4611
Query: 2426 GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLL 2485
SL F+ AW++L +WL
Sbjct: 4612 ----------------------------------SLDDARKRAKQFHEAWSKLMEWLEES 4637
Query: 2486 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI 2545
++ + S+ + D + I + + K + L + + ++LK KTS +
Sbjct: 4638 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4697
Query: 2546 ITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEG 2605
+ D + ++++WD + R+ +L E L S Q+ +A + L + +L +
Sbjct: 4698 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4757
Query: 2606 PYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINAS 2665
+D + I K K+L + ++V A +L+ S DD+ V + + ++
Sbjct: 4758 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELSTR 4816
Query: 2666 WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERLLE 2722
W ++ ++ LE R ++F + L WL EAE T VL D R L
Sbjct: 4817 WETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLI 4876
Query: 2723 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 2782
D KE MK+ ++ + E+ T + + ++ D ++ + + ++
Sbjct: 4877 DQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRARF 4926
Query: 2783 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQKQ 2840
E+ + + L ++ L+ LL WLQ + L+ + I + V+
Sbjct: 4927 EEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKAL 4986
Query: 2841 NDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LYQE 2883
H+ F E+ K+P + +T + I + ++ G ++ LY
Sbjct: 4987 IAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPS 5046
Query: 2884 PRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2937
+ E + V L+ K W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 5047 GSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 5092
Score = 316 bits (809), Expect = 3e-85
Identities = 546/2809 (19%), Positives = 1127/2809 (40%), Gaps = 353/2809 (12%)
Query: 337 LDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 396
L+++ E WL +E L+ ++D+ + + + + D+ +H+G + I
Sbjct: 1839 LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT 1898
Query: 397 QLGSKLIGTGKLSEDEE----------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 446
G++++ K + EVQ +++ R+ L +NL ++
Sbjct: 1899 ISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVD 1958
Query: 447 DLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 504
Q+ + L L E K EP+ D ++L+RQ+++ K LQ + +QV V
Sbjct: 1959 KYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE 2018
Query: 505 SLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRWVLLQDILLKWQRLT 561
L V+ ++ G A + Q K L D R+ ++ + +R LQ L + +
Sbjct: 2019 KLKKTAEVLLDARGSLLPAKNDIQ-KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2077
Query: 562 EEQCLFSAWLSEKEDAVNK-----IHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 616
+ W+ E ++ + +++T +D + K +L+ D+ ++ S+ +
Sbjct: 2078 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQD------IISKNIMLEQDIAGRQSSINAM 2131
Query: 617 YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTT 676
+ + T + S +A + + + + K +++ A++ + T + L +
Sbjct: 2132 NEKVKKFMETT-DPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVE--LFENL 2188
Query: 677 VMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDS-----EIRKRLDVDITELHSWI 731
+ T + T+ Q L + ++P + Q +S E +K L+V LHS +
Sbjct: 2189 SEKLQTFLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHKKHLEV----LHSLL 2241
Query: 732 TR-SEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE 790
S L S + + K N S +KF++++D + +
Sbjct: 2242 KEISSHGLPSDKALVLEKTNNLS--------------KKFKEMEDTIKEKK--------- 2278
Query: 791 GVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK 850
+++ EQL++ F L+ +W++ + E + + E+ K
Sbjct: 2279 ----EAVTSCQEQLDA----FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2330
Query: 851 IQPT----TPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKG--------- 897
+Q TP S + +C + ++ ++ I +K L +G
Sbjct: 2331 LQEKWSLKTPEIQKVNNSGISLC-NLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2389
Query: 898 --QGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQ-S 954
+G + D ++ ++ + ++ + EL T L + QE SA+ W+Q+ +
Sbjct: 2390 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--QKAQEESSAMMQWLQKMN 2447
Query: 955 ETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISR 1012
+T Q TD E ++ ++ + ++ ++ L++ + + L + E+ ++ P + +
Sbjct: 2448 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2507
Query: 1013 KYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 1072
+++ EI+ +W++L+ ++ QKLEE N L + Q LK+W+ E ++ + P
Sbjct: 2508 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2567
Query: 1073 ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA--EPEFASRLETELKEL 1130
D +L Q +Q ++L+ + T +P + GQ I + +P ++ +L +
Sbjct: 2568 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2627
Query: 1131 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1190
+WD + Q+ R + + + K+ Q L + + ++ + + PD +
Sbjct: 2628 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN 2687
Query: 1191 KAVEEMKRAKEEAQQKEAKVKL---LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLC 1247
+ +E ++ K+E QQ++ ++K+ L E +++++ + A+ L ++LE + +++ +
Sbjct: 2688 QQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--LSRQLEGILKSFKDVE 2745
Query: 1248 TRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLEN 1307
+ + L+ A H+ WL+ T + + IS LD LE+
Sbjct: 2746 QKAENHVQHLQSACASSHQFQQMSRDFQAWLD-------TKKEEQNKSHPISAKLDVLES 2798
Query: 1308 LMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1367
L++ +D ++TLT M E E E + + + A++ Q
Sbjct: 2799 LIKDHKD-------FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--------- 2842
Query: 1368 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN 1427
L+ I+ + +KQ+ + K++ SLE+ K+
Sbjct: 2843 -------LNTIKTNWDTFNKQVK-------------ERENKLKE-------SLEKALKY- 2874
Query: 1428 QGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETK 1487
KE + + ID Q L+++ KF L PA E + + K + E+ H +E
Sbjct: 2875 --KEQVETLWPWIDKCQNNLEEI--KFCL--DPAEGENSIAKLKSLQKEMDQHFGMVEL- 2927
Query: 1488 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK-----KQTENPKELDERVT 1542
LN+ N S+ E+ EV V + ++QK +Q + K E +T
Sbjct: 2928 ----------LNNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHSKKFCLENMT 2975
Query: 1543 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1602
+ E+ E K+QL+ C K + + M T++ +++ +
Sbjct: 2976 QKFKEFQEVSK---ESKRQLQ-CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3031
Query: 1603 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL---VEDKLSLLNSNWIAV 1659
+D K +++ + K ++V ++T+ + TL V++K S L + +
Sbjct: 3032 VDL----AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3087
Query: 1660 TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE-DVLKRLKA 1718
+ N + E FD +D + A+TL + E K K+ + L
Sbjct: 3088 G----HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3143
Query: 1719 ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 1778
N + +T + + +L+ + D + + Q ++L R A +++ +K
Sbjct: 3144 NANKTCKMMLATEETSPDLVGIKRD--LEALSKQCNKLLDRAQAREEQVEG-----TIKR 3196
Query: 1779 LEQFNSDIQK---LLEPLEA--EIQQGVNLKEEDFNKDMN----------EDNEGTVKEL 1823
LE+F S +++ LL+ E E Q V ++ E N+ +N E +G +++
Sbjct: 3197 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3256
Query: 1824 LQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQAD 1883
G L Q + ++ + + L +QR + E +++ +
Sbjct: 3257 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3316
Query: 1884 DLLKCLDDIEKKLASLPEPRDERKI--------KEIDRELQKKKEELNAVRRQAEGLSED 1935
LL + D E+ +A+ P E K+ K + R L +K + ++R+ E +
Sbjct: 3317 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI--- 3373
Query: 1936 GAAMAVEPT-QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-ISYVP 1993
A EP ++++ K+ ++S++ LN A+ T + LE IS V
Sbjct: 3374 --ATTAEPADKVKILKQLSLLDSRWEAL--LNKAE------------TRNRQLEGISVVA 3417
Query: 1994 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 2053
+ + +++ L +E+ L + L +Q K ++D + + + H
Sbjct: 3418 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL---HQ 3474
Query: 2054 KKTAALQSATPVERVKLQEALSQLDFQ---WEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 2110
+ R S+LDF + ++ + R +++ + F D
Sbjct: 3475 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEV 3534
Query: 2111 IFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQDGIGQRQTVVRTLNATGEEIIQQ 2168
WL E L K + + +K L+ LQ+ I R+ V G E+++Q
Sbjct: 3535 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3594
Query: 2169 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD- 2227
++ + I+Q+KL ++ R++++ K +D K LE+ + E WL++ +
Sbjct: 3595 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3654
Query: 2228 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2287
+ S + K ++ + + K L +E + +L LNE +L P E L
Sbjct: 3655 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG--L 3712
Query: 2288 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2347
E + + N ++ VS + +K EI+A I + + ++ + L W++ +L
Sbjct: 3713 EKMVAEDNERYRLVSDTITQKVEEIDAAIL-------RSQQFDQAADAELSWITETEKKL 3765
Query: 2348 EIYN-----QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK---EKPATQPVKRKL 2399
Q VQ+T + D+ + L K H + Q +K+KL
Sbjct: 3766 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3825
Query: 2400 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2459
+ + + + ++ E R Q + A +LV Q T E L
Sbjct: 3826 DKVLKNYDTICQINSE-RYLQLERAQ-------------SLVNQFWETYEELWPWLTETQ 3871
Query: 2460 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2519
S++ ++PA A L + ++ Q+ + + E+I + K + + +
Sbjct: 3872 SIISQLPAPA--------------LEYETLRQQQE---EHRQLRELIAEHKPHIDKMNKT 3914
Query: 2520 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2579
PQL EL S E +I ++ + +++E ++ R L+E + ST
Sbjct: 3915 GPQLLEL-----------SPGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQST 3962
Query: 2580 QWLEAKEEAEQVLGQARAKLESWKEGPYT---VDAIQKKITETKQLAKDLRQWQTNVDVA 2636
Q+ ++ +Q+L +E ++ P V+ I+++I+E K ++ D+ + Q +
Sbjct: 3963 QF---HDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 4019
Query: 2637 NDLALKLL-RDYSADDTRKVHMITENINAS---WRSIHKRVSEREAALEETHRLLQQFPL 2692
+++ R D + + ++ W +IH V EREA L + L ++F
Sbjct: 4020 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC 4079
Query: 2693 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD-LQGEIEAHTDVYHNL 2751
D + + + + L+D +++ + E +++ D LQ E+ D+ NL
Sbjct: 4080 DHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEEL----DIVINL 4135
Query: 2752 DENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 2811
L + G D ++++ +D +N W L K + LE + + LQ
Sbjct: 4136 GSE----LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4191
Query: 2812 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 2871
+ W+ + +L+ +PIG D V++Q + + FK E +
Sbjct: 4192 AVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAY------------------Q 4233
Query: 2872 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 2931
Q +E +E+L + L + ++ ++ E+ W+ L + Q K++ L
Sbjct: 4234 QQIE-MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4292
Query: 2932 LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 2991
L + Q A DEL L E + +PVG +++ L K L+ ++ + V V
Sbjct: 4293 LGQFQHALDELLAWLTHTEGLLSEQKPVGG-DPKAIEIELAKHHVLQNDVLAHQSTVEAV 4351
Query: 2992 NDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 3039
N L NL + LE LN RW+ + E R +QL A R
Sbjct: 4352 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4400
Score = 313 bits (803), Expect = 2e-84
Identities = 505/2706 (18%), Positives = 1066/2706 (39%), Gaps = 308/2706 (11%)
Query: 399 GSKLIGTGKLSEDEE-------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN- 450
G+ L G G + EE T +++ M ++ +E L + +K + L+ L LQ
Sbjct: 2373 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2432
Query: 451 -QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 509
++ + WL K + K ++ P D E +K QV+Q+K + +L+Q +V L
Sbjct: 2433 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2492
Query: 510 VVVVDESSGDHATAALEEQ-LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 568
+ + E + D A +Q L + +W + + T DR L++ + +
Sbjct: 2493 LTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLK 2552
Query: 569 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL- 627
WL EKE V+ + D N + + Q++ +L + +K +L + Q +LS
Sbjct: 2553 QWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2611
Query: 628 KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 687
++ S+ + L + WD+L +L I QA+ + T+
Sbjct: 2612 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS-----------------TQ 2654
Query: 688 EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFR 747
Q L++ ++L +D+++ L V T +A+ Q E A
Sbjct: 2655 YQSLLRSLSDKLSD----------LDNKLSSSLAVS--------THPDAMNQQLETAQKM 2696
Query: 748 KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK-QASEQLNS 806
K+ I++EK + + AQAL E + + V + +K + S QL
Sbjct: 2697 KQ-----------EIQQEKKQ--------IKVAQALCEDL-SALVKEEYLKAELSRQLEG 2736
Query: 807 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ-----MTTTAENWLKIQPTTPSEPTA 861
F + + N +++ + A +Q QQ+ + + T E K P + ++
Sbjct: 2737 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS-AKLDV 2795
Query: 862 IKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFS 919
++S +K KD L+ E+ + +++ LK +G L ++
Sbjct: 2796 LESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2855
Query: 920 DVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQ 979
V+ RE +L+ + ++Y+E + + W+ + + L + + E E + +L+
Sbjct: 2856 QVKERENKLKESLEKA--LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE-GENSIAKLK 2912
Query: 980 ALQSSLQEQQSGLYYLSTT------VKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLV 1033
+LQ + + + L+ T V E+ K+ ++ ++ + + + + L
Sbjct: 2913 SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLE 2972
Query: 1034 EHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD 1093
QK +E ++ + +Q K+ ++D+ +LG K L +
Sbjct: 2973 NMTQKFKEFQEVSKESKRQLQCAKE---QLDIH-----DSLGSQAYSNKYLTMLQTQQKS 3024
Query: 1094 IQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQWDHMCQQVYARKEALKGGL 1152
+Q ++ ++ Q + EA + + S + +++ + + + QQV + L+ L
Sbjct: 3025 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3084
Query: 1153 EKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR---------AKEEA 1203
+ Q + EM + ++E + + LQK E +K A +
Sbjct: 3085 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN 3144
Query: 1204 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1263
K K+ L TE + + +K++LE L+ L R + + +E
Sbjct: 3145 ANKTCKMMLATEETSPDLV--------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3196
Query: 1264 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHS----EDNPNQI 1319
E S L++ + L + E ++ + E I++ L+ + + + +
Sbjct: 3197 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3256
Query: 1320 RILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI------QSAQE 1370
L Q L + + +L+ N+RW+ L+++ +R L++++ Q A E
Sbjct: 3257 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3316
Query: 1371 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK 1430
+ S + E L K +A KV AQ+ QE + +Q L + ++E +K+ +
Sbjct: 3317 SLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QEQKLLQRLLDDRKSTVEVIKREGEKI 3373
Query: 1431 EAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI--------LDEVKMHLP 1482
++ + K+L + ++ A R E + L+ + L
Sbjct: 3374 ATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3432
Query: 1483 ALETKSVEQEVVQSQ---LNHCVNLYKSLSEV----KSEVEMVIKTGRQIVQKKQTENPK 1535
+E + V E + +Q L + +K+L + + + G+ + E+
Sbjct: 3433 TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3492
Query: 1536 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1595
+ ++ ++ Y E+ K R + L++ L ++ ++ L WL +L+K S
Sbjct: 3493 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV 3552
Query: 1596 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNS 1654
+ L + + + Q++I +K ++ G E LK G + +++DKL + +
Sbjct: 3553 QDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3612
Query: 1655 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDV 1712
+ +T + + L + + + + W+ ++ + L E++ K ++
Sbjct: 3613 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3672
Query: 1713 L---KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI-- 1767
K LK E + + +DS + ++ L+ R+ +E ++E N R+ +S I
Sbjct: 3673 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3732
Query: 1768 KTGKASIPLKELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED- 1815
K + + +QF+ +KL+ + ++Q + K +
Sbjct: 3733 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3792
Query: 1816 --NEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISH 1873
++ + +L++ G + ++E K + +K K + ++ + + S+R +
Sbjct: 3793 LRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3851
Query: 1874 QWYQYKRQADDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEEL 1922
Q+ ++L L + + ++ LP P + R+++E+ E + +++
Sbjct: 3852 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3911
Query: 1923 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1982
N Q LS G +++ + + +I+ ++ A + + T
Sbjct: 3912 NKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDK 3967
Query: 1983 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 2042
D LE L + +S + ++++ ++ + D E L E+LK + +
Sbjct: 3968 IDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMI 4027
Query: 2043 QSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW 2102
SG D S K +Q+ L Q+ F WE ++ + ++R+ + +E
Sbjct: 4028 ARSGGTDKDISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 4074
Query: 2103 RRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTV 2154
+F D + + + F+R + P + E A+ ++E DG+ + +
Sbjct: 4075 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDI 4131
Query: 2155 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2214
V L G E+I + D I+++ + LN W + K DR +LEE ++Q
Sbjct: 4132 VINL---GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 4188
Query: 2215 DLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV 2273
L W++ A +AS+ + +K+++E++K E +Q +++LN +
Sbjct: 4189 GLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELL 4248
Query: 2274 LVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEE 2331
L EE DK +++ L + L W + + +Q ++E + LGQ + L++L
Sbjct: 4249 LKKVT---EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-- 4303
Query: 2332 QLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQ 2383
L WL+ L Q G E E+A V A Q VE + G
Sbjct: 4304 -----LAWLTHTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGN 4356
Query: 2384 HLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2441
L + + ++ KLE L+ W+ V
Sbjct: 4357 DLIESSAGEEASNLQNKLEVLNQRWQNV-------------------------------- 4384
Query: 2442 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2501
++T K ++ +L F+ +L WL+ ++ + + + + G E
Sbjct: 4385 -----LEKTEQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4435
Query: 2502 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2561
E + E + + L+ Q + + + A T I I ++ +W+ V+
Sbjct: 4436 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVE 4494
Query: 2562 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2621
L R+ +L E L + ++ + ++ L QA L +D + +I E K
Sbjct: 4495 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4554
Query: 2622 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2681
A ++ + + + L D + + ++ + W + +R+ ER +L+
Sbjct: 4555 FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLD 4614
Query: 2682 ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2741
+ + +QF K + WL E+E + + + + D +K + Q ++ Q +
Sbjct: 4615 DARKRAKQFHEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSL 4668
Query: 2742 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSD 2801
A VY + + + +DD + L L + KW + KS+ ++ LE +
Sbjct: 4669 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4728
Query: 2802 QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 2861
+ +LQ L+ WL + +L+ P+ GD V D H+AF++EL +
Sbjct: 4729 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT------ 4782
Query: 2862 LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 2921
++ L + REL E +++ + ++ Q +E++T WE + S
Sbjct: 4783 -------------SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISK 4827
Query: 2922 QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVK 2975
Q +++ L + +E L L +AE + D LID ++ ++K++
Sbjct: 4828 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4887
Query: 2976 ALRGEI 2981
R E+
Sbjct: 4888 EKRAEL 4893
Score = 277 bits (708), Expect = 2e-73
Identities = 491/2725 (18%), Positives = 1089/2725 (39%), Gaps = 258/2725 (9%)
Query: 341 QTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGS 400
Q L+E+L W+ + E +L+ QG++ + ++D + D+ Q + + +
Sbjct: 2077 QDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2136
Query: 401 KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKELND 458
K + T S + +Q +M L++R+ E + + + ++L ++L
Sbjct: 2137 KFMETTDPST--ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2194
Query: 459 WL-TKTEERTRKMEEEPLGPDLEDLKRQVQQ-------HKVLQEDLEQEQVRVNSLTHMV 510
+L TKT+ T E + G D+ +L + +Q+ HK + LE + ++
Sbjct: 2195 FLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHK---KHLEVLHSLLKEISSHG 2248
Query: 511 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 570
+ D++ T L ++ K + D + ++ Q+ L +Q L + +W
Sbjct: 2249 LPSDKALVLEKTNNLSKKFKEMEDT----IKEKKEAVTSCQEQLDAFQVLVKS---LKSW 2301
Query: 571 LSEKEDAVNKIHTT-GFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 629
+ E V + + G +D + L +KL + +SLK + + N
Sbjct: 2302 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQ--------------EKWSLKTPEIQKVNN 2347
Query: 630 KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQ--AVTTTQPSLTQTTVMETVTTVTT- 686
++ L N + V K+ A + AV + + T T +T+
Sbjct: 2348 SGIS------LCNLI----SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2397
Query: 687 -REQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL----QSP 741
++ + H E+L K ++ ++ + + + W+ + Q+P
Sbjct: 2398 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2457
Query: 742 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 801
A E + +++ + E E + K+Q+ L+E+ + A KQ
Sbjct: 2458 --APTDTEAVKTQVEQN-KSFEAELKQNVNKVQELKDKLTELLEENPDTP-EAPRWKQML 2513
Query: 802 EQLNSRWIEFCQLLSERLNWLEYQ-NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 860
+++S+W E QL +R LE NN+ F QL+Q E + + +P
Sbjct: 2514 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2573
Query: 861 AIKSQLKICKDEVNRLSGLQPQIERLKIQSIA-LKEKGQGPMF---LDADFVAFTNHFKQ 916
+ +Q + + + + +PQ E+L L G+ P + A T +
Sbjct: 2574 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2633
Query: 917 VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 976
+ + R + + +YQ + ++ + + KLS T + M Q+L
Sbjct: 2634 LTGQLSDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLE 2691
Query: 977 ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSE-ISRKYQSEFEEIEGRWKKLSSQLVEH 1035
Q ++ +Q+++ + +++S E + + + E I +K + + H
Sbjct: 2692 TAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH 2751
Query: 1036 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1095
Q L+ + Q + + W+ + P ++L+ +K + +
Sbjct: 2752 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2811
Query: 1096 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1155
G+ + + + + L+ +L + T WD +QV R+ LK LEK
Sbjct: 2812 AQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 2871
Query: 1156 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTE 1215
+ ++ + + W+ + + E F P E + ++ ++K ++E Q V+LL
Sbjct: 2872 LKYKEQVETLWPWIDKCQNNLEEIKF-CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNN 2930
Query: 1216 SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKAN 1275
+ NS+++ + +E + E ++L + +L+ K LE + + E +++
Sbjct: 2931 TANSLLSVCE-IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESK 2989
Query: 1276 KWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI---LAQTLT----- 1327
+ L + +L +++ G ++ L L+ + + +Q+ + LAQ L
Sbjct: 2990 RQLQCAKEQLDIHDSL-GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD 3048
Query: 1328 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1387
G D L+ ++ET L ++ + LE +Q + ++ + D
Sbjct: 3049 SKGTSDVLL--QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD 3106
Query: 1388 QLAAYIADKVDAAQMPQEAQKIQSDLTSHE----------------ISLEEMKKHNQGKE 1431
+L + DA + ++ + I++ L E ++ EE G +
Sbjct: 3107 ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3166
Query: 1432 AAQRVLSQ-----IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALET 1486
LS+ +D AQ + + V + ++ F +L+E ++L + + H +
Sbjct: 3167 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE---FYSKLKEFSILLQKAEEHEESQGP 3223
Query: 1487 KSVEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTAL 1544
+E E + QLN K + ++ + + V G+ ++Q ++ + + L+ + +
Sbjct: 3224 VGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDV 3283
Query: 1545 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1604
+ L KV +R QL++ L + + + L W+ T+ + + +
Sbjct: 3284 NARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK 3343
Query: 1605 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRA 1663
+++ K Q+ ++ +K ++ I GE + T + + + +LSLL+S W A+ ++A
Sbjct: 3344 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3403
Query: 1664 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELN 1721
E L + F + ++ + +W+ + L E Q E+ + + KA +
Sbjct: 3404 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3463
Query: 1722 DIRPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL 1776
DI Q+ ++++R D + +V+ ++ F+ + + I+ + S
Sbjct: 3464 DIINHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSR 3515
Query: 1777 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRI 1834
EL Q K+ E E+ +N + +K +D EG K+ + R+
Sbjct: 3516 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRV 3569
Query: 1835 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1894
E + + KQ + Q N L+ L+ + L I + K + D+ K D+ K
Sbjct: 3570 LQE---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3626
Query: 1895 KLASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRW 1952
L + R++ EL K E+ + + + L + A+ A + +L K
Sbjct: 3627 TLEQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEA 3683
Query: 1953 REIESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 2008
+ ++ ++ A + V RE ++ ED V T ++ + A+L
Sbjct: 3684 KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAIL 3742
Query: 2009 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 2068
+Q A D + K+ SL +I+ Q+S ++ + + L+ ++ +
Sbjct: 3743 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3802
Query: 2069 -----KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ------- 2114
K+ A S+ + Q +K++K+ K+ + E++ + + NQ
Sbjct: 3803 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 3862
Query: 2115 ---WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2169
WLTE + + + P E + + ++L++ I + + + +N TG ++++ S
Sbjct: 3863 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 3922
Query: 2170 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADN 2228
SI QEK + + + ++ + + R L+E + ++F +++ + LE +
Sbjct: 3923 PGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 3981
Query: 2229 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDK 2286
+ P + +++KE++ + K + ++ Q + + L + G ++ + + ++
Sbjct: 3982 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4041
Query: 2287 LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIR 2344
+++KL Q W + + E+ EA++ D+ +L +K +H L++ + +
Sbjct: 4042 VQDKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQ 4092
Query: 2345 NQLEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVK 2396
+ + P + Q+ E A + Q +++ +++ G L +P VK
Sbjct: 4093 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4152
Query: 2397 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE 2456
+ +++L+S W ++N+ ++ I KLE
Sbjct: 4153 KSIDELNSAWDSLNKAWKD-----------------------------------RIDKLE 4177
Query: 2457 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2516
+ A + + DW+ + + S + DLE + + I + K +
Sbjct: 4178 EA------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4231
Query: 2517 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2576
Q++ ++E L A+ L K + + + + D + ++ WD ++E + NR+ +L L
Sbjct: 4232 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4291
Query: 2577 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2636
Q+ A +E L L K AI+ ++ + L D+ Q+ V+
Sbjct: 4292 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4351
Query: 2637 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2696
N L+ + ++ + E +N W+++ ++ +R+ L+ R + F ++E
Sbjct: 4352 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4411
Query: 2697 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2756
WLT+ E + + L + KE + ++ EA + Y +L + Q
Sbjct: 4412 LQQWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQ 4465
Query: 2757 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2816
++L S + + + ++N+ KW + K ++ LE + + H SLQ+ + W
Sbjct: 4466 QMLARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4524
Query: 2817 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQP 2873
L + L+ + V Q D H+ F E+ + I+ +T ++ F +Q
Sbjct: 4525 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4584
Query: 2874 LEGLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQR 2923
+ ++ L + + R + V + L RK+A++ + W KL +W
Sbjct: 4585 VVLIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLE 4635
Query: 2924 KIDETLERLQELQEATDELDLKLRQ 2948
+ +++L+ E+ D++ +L Q
Sbjct: 4636 ESEKSLDSELEIANDPDKIKTQLAQ 4660
Score = 226 bits (576), Expect = 3e-58
Identities = 345/1758 (19%), Positives = 713/1758 (40%), Gaps = 172/1758 (9%)
Query: 328 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 387
+ L E+ ++ R+Q ALE +LSW++ E+ + Q S + +VVK Q + L
Sbjct: 3299 AQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD 3358
Query: 388 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 447
+ V I + G K+ T + + ++ ++ +Q++LL+SRWE L + + L + +
Sbjct: 3359 RKSTVEVIKREGEKIATTAEPA--DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3416
Query: 448 LQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 505
Q ++ L+ LN+WLT E+R + EP+G L+ Q+ QHK L++D+ + N
Sbjct: 3417 AQQFHETLEPLNEWLTTIEKRL--VNCEPIGTQASKLEEQIAQHKALEDDI----INHNK 3470
Query: 506 LTHMVVVVDES----SGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 561
H V + +S S ++ +L + I + R LLQ L +
Sbjct: 3471 HLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFG 3530
Query: 562 EEQCLFSAWLSEKEDAVNKI-----HTTGFKDQNEMLSSLQKLAVLKAD---------LE 607
E++ WL+E D ++K+ T G Q L LQ+ +L+ LE
Sbjct: 3531 EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLE 3590
Query: 608 KKKQSMGKLYSLKQDLLSTLKNK--------------------------SVTQKTEAWLD 641
KQ+ G + QD L +K + S ++ WLD
Sbjct: 3591 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3650
Query: 642 NF---ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK-HAQE 697
++ V K E+++ + + + +++++ V++ LV A+E
Sbjct: 3651 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRARE 3710
Query: 698 ELPP--PPPQKKRQITVDSEIRKRLDVDITELH------------SWITRSEAVLQSPEF 743
L ++ ++ D+ +K ++D L SWIT +E L S
Sbjct: 3711 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3770
Query: 744 AIFRKEGNFSDLK-EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE 802
++ + L+ +K +E + + + D +S ++ E S+K+ +
Sbjct: 3771 IRLEQDQTSAQLQVQKTFTMEILRHKDI--IDDLVKSGHKIMTACSEE--EKQSMKKKLD 3826
Query: 803 QLNSRWIEFCQLLSERLNWLEYQNNII-AFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 861
++ + CQ+ SER LE +++ F+ ++L T ++ + P E
Sbjct: 3827 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3886
Query: 862 IKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMF-LDADFVAFTNHFKQVFSD 920
++ Q + + ++ +P I+++ L E G F + +VA + Q+ D
Sbjct: 3887 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3946
Query: 921 VQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQA 980
V+ R L ++ + + I +++ +L P + E +++++ E +
Sbjct: 3947 VKKRAVALDEAIS--QSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4004
Query: 981 LQSSLQEQQSGLYYLSTTVKEM---SKKAPSEISRK-YQSEFEEIEGRWKKLSSQLVEHC 1036
+ +++ Q L +EM S +IS K Q + +++ W+ + + + E
Sbjct: 4005 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4064
Query: 1037 QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKE-EWPALGDSEILKKQLKQCRLLVSDIQ 1095
KL + M K +L + + F+++ E P + D ++K+Q + + +I
Sbjct: 4065 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI-DPSVVKQQQEAAETIREEID 4123
Query: 1096 TIQPSLNSV-NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1154
+Q L+ V N G + I EP+ ++ + ELN+ WD + + R + L+ ++
Sbjct: 4124 GLQEELDIVINLGSELIAACGEPD-KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4182
Query: 1155 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1214
V Q L + +W+ A + + +++ +EE+K+ K EA Q++ +++ L
Sbjct: 4183 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4242
Query: 1215 ESVNSVIAQAPPVA-QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEK 1273
++ + + + ++ L L + L R+ + LE + L++
Sbjct: 4243 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4302
Query: 1274 ANKWLNEVEFKLKTTENIPGGAEEISEVLDS---LENLMRHSEDNPNQIRILAQTLTDGG 1330
WL E L + + G + I L L+N + + + L +
Sbjct: 4303 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4362
Query: 1331 VMDELIN--EELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1388
+E N +LE N RW+ + E+ +R++ L+ +++ A+ + +Q+ LT ++
Sbjct: 4363 AGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERH 4422
Query: 1389 LAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEE-----MKKHNQ-----GKEAAQR 1435
L A +P+ A++ + ++ + + EE M+K Q K A
Sbjct: 4423 LLA----SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4478
Query: 1436 VLSQIDVAQKKLQDVSMKF--------RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1487
+ I+ ++K + V K F LQ+ L + + L
Sbjct: 4479 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4538
Query: 1488 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLH 1547
S+ + V Q++ ++ + ++ + KTG + Q ++ + + +++
Sbjct: 4539 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4598
Query: 1548 YNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEV 1607
+ ++ ++ ER + L+ K +++ + + L EWL ++ L + P + +++
Sbjct: 4599 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4658
Query: 1608 AWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1665
A K QK + + + G +L KT L ++D LS L W + ++ E
Sbjct: 4659 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4718
Query: 1666 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK-----KKPQQKEDVLKRLKAEL 1720
N L E F + + W+ + + L E + D K + EL
Sbjct: 4719 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4778
Query: 1721 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS--HRIKTGKASIPLKE 1778
V + + A L+ D V+ Q+ EL+ R+ + K + L++
Sbjct: 4779 GKRTSSVQALKRSARELIEGSRDD-SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4837
Query: 1779 LEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1833
E+F+S + LLE L AE +Q GV +ED + + + ++ +K+L ++ L +
Sbjct: 4838 AEEFHSVVHALLEWL-AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKA 4896
Query: 1834 IT------------------------DERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1869
T R E + +Q Q +AL L + +++ L
Sbjct: 4897 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIA--KQELL 4954
Query: 1870 EISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1929
E W Q+ L D +K++ P++ ++K + E Q EE+ +
Sbjct: 4955 EALLAWLQWAETT------LTDKDKEVI----PQEIEEVKALIAEHQTFMEEMTRKQPDV 5004
Query: 1930 EGLSEDGAAMAVEPTQIQ 1947
+ +++ A +P+ +Q
Sbjct: 5005 DKVTKTYKRRAADPSSLQ 5022
Score = 221 bits (563), Expect = 1e-56
Identities = 112/231 (48%), Positives = 153/231 (66%), Gaps = 5/231 (2%)
Query: 7 DEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTR 66
DER+ VQKKTFTKW+N K K H+ +L+ DL+DG L+ LLE L+G LP+EKG R
Sbjct: 31 DERDKVQKKTFTKWINQHLMKVRK-HVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMR 89
Query: 67 VHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAG 126
H L NV AL L+ V LVNI + DI DGN KLTLGLIW IILH+Q+ ++ ++
Sbjct: 90 FHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDI--HVTGE 147
Query: 127 LQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQ 186
+ ++++ LL W +Q+T Y + NFTT W DG NA+IH +RPDL D N+V Q
Sbjct: 148 SEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV-Q 206
Query: 187 SATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 237
S LEHAF +A ++G+ +LLDPEDVD + PD+KS++ Y++SL+ P+
Sbjct: 207 SNLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK 256
Score = 205 bits (521), Expect = 8e-52
Identities = 284/1564 (18%), Positives = 642/1564 (41%), Gaps = 148/1564 (9%)
Query: 264 LHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA-YTQAAYVTTSDPTRSPFPSQHLEAPE 322
++H H Q +++ + + K +S ++Q Y+ + + S
Sbjct: 3466 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCN 3525
Query: 323 DKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYM 382
K FG E EV L + + + LS L + + + + +++ V+++
Sbjct: 3526 AKIFG----EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE--------- 3572
Query: 383 MDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH 442
D+ + V L G +L+ + + DE +Q+++ + +R++ + S + L
Sbjct: 3573 -DILLRKQNVDQALLNGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLE 3629
Query: 443 RVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQ 500
+ L + + +EL WL K E E + L E+ + + K L+++ + +
Sbjct: 3630 QALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG--EEASQAQMRPKELKKEAKNNK 3687
Query: 501 VRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRL 560
++SL + + E A LE+ + +R+ + + + +L+ Q+
Sbjct: 3688 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3747
Query: 561 TEEQCLFSAWLSEKEDA-------------------VNKIHTTGFKDQNEMLSSLQKLA- 600
+ +W++E E V K T +++ L K
Sbjct: 3748 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3807
Query: 601 -VLKADLEKKKQSMGKLYS--LKQ-DLLSTLKNKSVTQ--KTEAWLDNFARCWDNLVQKL 654
++ A E++KQSM K LK D + + ++ Q + ++ ++ F ++ L L
Sbjct: 3808 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 3867
Query: 655 EKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ--EELPPPPPQ------- 705
++ + ISQ P+L T+ + +++ +H +++ PQ
Sbjct: 3868 TETQSIISQLPA---PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3924
Query: 706 -----KKRQITVDS-------EIRKR---LDVDITELHSWITRSEAVLQSPEFAIFRKE- 749
+++ + D+ +++KR LD I++ + + + +L+S E + R
Sbjct: 3925 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 3984
Query: 750 -----GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMV------NEGVNADSIK 798
+KE+++ + + KLQ + + E+M+ ++ ++A +++
Sbjct: 3985 PPSISAEVEKIKEQISENKNVSVD-MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4043
Query: 799 QASEQLNSRWIEFCQLLSER-LNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 857
+Q+ W L+ ER L+ F+ L +++++
Sbjct: 4044 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4103
Query: 858 EPTAIKSQLKICKDEVNRLSGLQPQIE---RLKIQSIALKEKGQGPMF---LDADFVAFT 911
+P+ +K Q + + + GLQ +++ L + IA + P+ +D A+
Sbjct: 4104 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4163
Query: 912 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 971
+ K + E+ +Q ++YQ+ + A+ WV + KL+ TD E +
Sbjct: 4164 SLNKAWKDRIDKLEEAMQAA------VQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 4217
Query: 972 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEFEEIEGRWKKLSS 1030
+Q++ EL+ +S +QQ + L+ + + KK E + Q E++ W L
Sbjct: 4218 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 4277
Query: 1031 QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 1090
+++ KLE + L + Q+ + L W+ + L E+ P GD + ++ +L + +L
Sbjct: 4278 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4337
Query: 1091 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1150
+D+ Q ++ +VN+ G + + E AS L+ +L+ LN +W ++ ++ RK+ L G
Sbjct: 4338 QNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDG 4397
Query: 1151 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKV 1210
L + ++ ++ +W+T E L P+ ++ + + KE
Sbjct: 4398 ALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4457
Query: 1211 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1270
K L + ++A+ P A+ + +++ L ++ + T+LN + LEE E +
Sbjct: 4458 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4517
Query: 1271 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1330
L+ WL + E L + + +D + + QI L +T T
Sbjct: 4518 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4577
Query: 1331 VMDE-----LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI 1385
+ LI L + SRW ++ + V R + L+ + + A++ ++ + E L
Sbjct: 4578 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4637
Query: 1386 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQK 1445
+K L + + ++ + KI++ L H +E +K K + ++ + K
Sbjct: 4638 EKSLDSEL-------EIANDPDKIKTQLAQH----KEFQKSLGAKHSVYDTTNRTGRSLK 4686
Query: 1446 ----------KLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPAL------ 1484
KL D+ + R + K + +L+E+ + + L AL
Sbjct: 4687 EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYR 4746
Query: 1485 -ETKSVEQEVVQSQLNHCVNL-------YKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1536
E + E + V ++ +NL K L + S V+ + ++ R++++ + ++
Sbjct: 4747 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR-DDSSW 4805
Query: 1537 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1596
+ ++ L + + A ++ +LE L+ + + ++ L EWLA + L +
Sbjct: 4806 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4865
Query: 1597 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDKLSLLNSN 1655
L + + K K++E+++ L T +G+ + + T ++ ++++ +
Sbjct: 4866 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4925
Query: 1656 WIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR 1715
+ V + A++ L + + ++ + W+ A+T L + +K+ Q+ + +K
Sbjct: 4926 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 4985
Query: 1716 LKAE 1719
L AE
Sbjct: 4986 LIAE 4989
Score = 178 bits (452), Expect = 8e-44
Identities = 527/2759 (19%), Positives = 1063/2759 (38%), Gaps = 415/2759 (15%)
Query: 452 KLKELNDWLTKTEE--------RTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 503
KLK +N L T+ T+ EEE + D +++ + K + ++++++
Sbjct: 1170 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 1229
Query: 504 NSLTHMV----VVVDESSGDHATAALE-----EQLKVLGDRWANICRWTEDRWVLLQDI- 553
++L + + DE + L+ E+ L +RW N+ ++R L+ I
Sbjct: 1230 HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 1289
Query: 554 -LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQS 612
LK+ R T W+ + E KI ++ + + L + +L +++E K+
Sbjct: 1290 KSLKYYRDTYHP--LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1347
Query: 613 MGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 672
M + + +T+K+ + T + D+ + K S A Q +
Sbjct: 1348 MDECQKYAEQYSATVKDYELQTMT------YRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1401
Query: 673 TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWIT 732
T + T+ T+ +K A + L ++K +++ E ++ ++ EL W++
Sbjct: 1402 DLRTRYTALVTLMTQ---YIKFAGDSLKRLEEEEK---SLEEEKKEHVE-KAKELQKWVS 1454
Query: 733 RSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV 792
L+ E K G K+K+++ E + K +L +A ++ Q + + +
Sbjct: 1455 NISKTLKDAE-----KAGKPPFSKQKISS--EEISTKKEQLSEALQTIQLFLAKHGD--- 1504
Query: 793 NADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ 852
K E+ N L +++ L+ N++ F L+QL++ T+ + +K+
Sbjct: 1505 -----KMTDEERNE--------LEKQVKTLQESYNLL-FSESLKQLQESQTSGD--VKV- 1547
Query: 853 PTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN 912
E + + + K+++ + L Q E I G F+ D
Sbjct: 1548 -----EEKIVAERQQEYKEKLQGICDLLTQTENRLI--------GHQEAFMIGDGTVELK 1594
Query: 913 HFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET--KLSIPQLSVTDYEI 970
+ Q++++ELQ Q + A+ V+ +E K + +LS D +
Sbjct: 1595 KY-------QSKQEELQKDM--------QGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1639
Query: 971 MEQRLGE--LQALQSSLQEQQSGLYY---LSTTVKEMSKKAPS-----EISRKYQSEFEE 1020
+EQ+L E ++ Q +L+ +QS ++T +KE ++K + E K ++ +
Sbjct: 1640 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1699
Query: 1021 IEGRWKKLSSQLVEHCQKLEE-----QMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 1075
+ K +H Q +E+ Q + + + E DV +
Sbjct: 1700 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1759
Query: 1076 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD 1135
++ +K Q ++S Q + + S +K PE +L+ +KEL ++
Sbjct: 1760 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYE 1819
Query: 1136 HMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEE 1195
+ + + E+ D +E W+ Q+E+E + + L ++
Sbjct: 1820 TALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR 1879
Query: 1196 MKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ------------EALKKELETLTTNY 1243
K E+ + ++ +T S N V+ A ++ ++++L+ T +
Sbjct: 1880 QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRF 1939
Query: 1244 QWL---CTRLNGKCKTLEEVWACWHE----LLSYLE----KANKWLNE--------VEFK 1284
+ L C L K L + + + + LL+ L+ A+K L+E ++ +
Sbjct: 1940 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 1999
Query: 1285 LKTTENIPG----------------------------GAEEISEVLDSL----ENLMRHS 1312
L+ T+ + G +I + LD + E+L +
Sbjct: 2000 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSV 2059
Query: 1313 EDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEA------------VRRQKL 1360
+ +++I TLT + + ++E L+ + L E+ + + +
Sbjct: 2060 NERNEKLQI---TLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIM 2116
Query: 1361 LEQSIQSAQETEKSLH-LIQESLTFIDKQLAAYIADKVD--AAQMPQEAQKIQSDL---- 1413
LEQ I Q + +++ +++ + D A+ + K+ +A+ + + K + L
Sbjct: 2117 LEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKME 2176
Query: 1414 ---TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 1470
T E+ +K E + L+++DV K + ++S Q +QES
Sbjct: 2177 ELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELS-------------QYMQES 2223
Query: 1471 KMILDEVKMHLPALET--KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK 1528
E K HL L + K + + S + +LS+ E+E IK ++ V
Sbjct: 2224 TSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTS 2283
Query: 1529 KQTENP-------------KELDERVTALKLHY--NELGAKVTERKQQLEKCLKLSRKMR 1573
Q + KE ++V ++ + +LG + + K+ EK + +++
Sbjct: 2284 CQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ 2343
Query: 1574 KEMN---VLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEV 1630
K N L ++A +AV+ + L+ E G AT E L SI +
Sbjct: 2344 KVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE---GTATNTEEFWANKGLTSIKKD 2400
Query: 1631 GEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 1690
+ L++DK++ LN+ + EE ++ QK +T TKW
Sbjct: 2401 MTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT-------ATKW 2453
Query: 1691 IIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLM--------ANRG 1742
Q ++E K Q +++ K +AEL KV +D+ L+ A R
Sbjct: 2454 --QQTPAPTDTEAVKTQVEQN--KSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRW 2509
Query: 1743 DHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVN 1802
++ + ELN I + K ++S L + + + +++ L +E E+ V
Sbjct: 2510 KQMLTEIDSKWQELNQ--LTIDRQQKLEESSNNLTQFQTVEAQLKQWL--VEKELMVSV- 2564
Query: 1803 LKEEDFNKDMNEDNEGTVKELLQR--------------GDNLQQRITDERKREEIKIKQQ 1848
L + +M V+ LLQ G + R ++ I +K+Q
Sbjct: 2565 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGI-VKEQ 2623
Query: 1849 L--LQTKHNALKDLRSQR---RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1903
L + K ++L S R +A+ S Q+ R D L LD+ K +SL
Sbjct: 2624 LAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN--KLSSSLAVST 2681
Query: 1904 DERKIKEIDRELQKKKEELNAVRRQ---AEGLSEDGAAMAVEP-TQIQLSKRWREIESKF 1959
+ + QK K+E+ ++Q A+ L ED +A+ E + +LS R++E
Sbjct: 2682 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELS---RQLEGIL 2738
Query: 1960 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV---EQLLNA 2016
F+ + + V+ L+ + S +++ QA L+ EQ +
Sbjct: 2739 KSFKDVEQKAENHVQH-----------LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2787
Query: 2017 PDLCAKD-FEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALS 2075
P D E L K K+ +L S + ++ L E+ LQ L+
Sbjct: 2788 PISAKLDVLESLIKDH---KDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLN 2844
Query: 2076 QLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQI---PENW 2132
+ W+ NK K+R+ + S+EK ++ ++ W+ + + L + + P
Sbjct: 2845 TIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG 2904
Query: 2133 EHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC 2192
E++ K LK LQ + Q +V LN T ++ + D ++ ++ SL + V
Sbjct: 2905 ENSIAK--LKSLQKEMDQHFGMVELLNNTANSLL-SVCEIDKEVVTDENKSLIQKVDMVT 2961
Query: 2193 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-------DNIAS----------IPLE 2235
+QL +K LE EFQ E L+ A D++ S + +
Sbjct: 2962 EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3021
Query: 2236 PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLK--- 2292
Q LK +++ K L ++L + K ++ VL+ +E L ++
Sbjct: 3022 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSD----VLLQVETIAQEHSTLSQQVDEKC 3077
Query: 2293 ---QTNLQWI----KVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRN 2345
+T LQ I R + + E + ++ + + + E L++Q + +L +
Sbjct: 3078 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEA 3137
Query: 2346 QLEIYNQPNQEGPFDVQETEIA-----------------------VQAKQPDVEEILSKG 2382
+ + N+ + E + QA++ VE + +
Sbjct: 3138 LMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRL 3197
Query: 2383 QHLYKEKPATQPVKRKLED-------LSSEWKAVNRLL-----------QELRAKQPD-- 2422
+ Y + + +K E+ + E + +N+ L + L+ KQ D
Sbjct: 3198 EEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVN 3257
Query: 2423 -LAPGLTTIGASPTQTVTLV--TQPVVTKETAISKLEMPSSLMLEVPAL--ADFNRAWTE 2477
L GL A T T L V + ++K + L+ L F A
Sbjct: 3258 WLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALES 3317
Query: 2478 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 2537
L W+ ++++ +Q+ + + + I +QK + L+ R+ +E + + + T
Sbjct: 3318 LLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAT-T 3376
Query: 2538 SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 2597
+ + I ++ + ++W+ + + R +QL + + Q+ E E + L
Sbjct: 3377 AEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEK 3436
Query: 2598 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHM 2657
+L + + ++++I + K L D+ ++ A + L S +D V
Sbjct: 3437 RLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQS 3496
Query: 2658 ITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRK 2717
+ + I ++ R L++ + F D + + WL E +
Sbjct: 3497 KLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH---------DKL 3547
Query: 2718 ERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDE---NSQKILRSLEGSDDAVLLQRR 2774
+L + L KQ +L+ E N+D+ N ++L+ G D+ +++Q +
Sbjct: 3548 SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTG-DEVLIIQDK 3606
Query: 2775 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDE-LSRQAPIGGD 2833
L+ + ++ ++ K S ++ LE + +RLH + +EL WL + E LS + +
Sbjct: 3607 LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG 3666
Query: 2834 FPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQP---LEGLEKLYQEPRELPPE 2890
A Q Q + K+E K + ++ S E L P EGLEK+ E
Sbjct: 3667 EEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAE-----DN 3720
Query: 2891 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-DLKLRQ 2948
ER + V+ + ++ EE+ + L S + + D L + E ++ L D++L Q
Sbjct: 3721 ERYRLVSDTITQKVEEI----DAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3775
Score = 38.9 bits (89), Expect = 0.095
Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 27/168 (16%)
Query: 2810 LQELLVWLQLKDDELSRQAPIGGDFPAVQKQ----NDVHRAFKR-ELKTKEPVIMSTLET 2864
+Q+LL W+ +L R G D P+V+ +VHRA + E KE I T
Sbjct: 608 VQDLLNWVDEMQVQLDR-TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 666
Query: 2865 VRIFLT-EQPLEGLEKLY--------QEPRELPP----EERAQN-VTRLLRKQAEEVNTE 2910
+ LT + L LE Y + R L RA N + L K+ EEV +
Sbjct: 667 APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYD 726
Query: 2911 WEKLNL-------HSADWQRKIDETLERLQELQEATDELDLKLRQAEV 2951
W + N + A+ R++D+ E ++ +QE ++L L+ A +
Sbjct: 727 WSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 774
>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
Length = 5171
Score = 325 bits (832), Expect = 7e-88
Identities = 545/2835 (19%), Positives = 1126/2835 (39%), Gaps = 316/2835 (11%)
Query: 338 DRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQ 397
++ QT LE L + + E+S ++ +F H+ ++ +L
Sbjct: 1864 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-----------EVLH 1912
Query: 398 LGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKE 455
K I + L D+ V E+ N L+ +++ + EK+ + + +D +K
Sbjct: 1913 SLLKEISSHGLPSDKAL-VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 1971
Query: 456 LNDWLTKTEERTRKMEE----EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 511
L W+ +T ++ ++ E LG LED K+ ++ + ++++ SL +++
Sbjct: 1972 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2031
Query: 512 VVDESSGDHATAALEEQLKVLGDR---------WAN------------ICRWTEDRWVLL 550
V + A AA++ VL WAN I ED +LL
Sbjct: 2032 AVTTPA--KAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2089
Query: 551 QDI-------LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS-LQKLAVL 602
+D L K Q+ EE WL + K T E + + +++
Sbjct: 2090 KDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSF 2149
Query: 603 KADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS 662
+A+L KQ++ K+ LK L L+ T + W D+ Q+L + T
Sbjct: 2150 EAEL---KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEI-DSKWQELNQLTIDRQ 2205
Query: 663 QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV 722
Q + + +LTQ +E
Sbjct: 2206 QKLEESSNNLTQFQTVEA------------------------------------------ 2223
Query: 723 DITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 782
+L W+ E ++ S + + +++V + +E A + + + + + Q
Sbjct: 2224 ---QLKQWLVEKELMV-SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2279
Query: 783 LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQN-NIIAFYNQLQQLEQM 841
++ + + +K+ + +W LS+R +W++ + + L+ L
Sbjct: 2280 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2339
Query: 842 TTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQ----SIALKEKG 897
+ +N L + P A+ QL+ + + + QI+ + S +KE+
Sbjct: 2340 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE- 2398
Query: 898 QGPMFLDADFVAFTNHFKQVFSDVQAR-EKELQTIFDTLPPM-RYQETMSAIRTWVQQSE 955
+L A+ + F DV+ + E +Q + ++Q+ + W+ +
Sbjct: 2399 ----YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2454
Query: 956 TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 1015
+ + +++E + + + +L Q + + K Q
Sbjct: 2455 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2514
Query: 1016 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW---- 1071
+ I+ W + Q+ E KL+E + K K + ++TL W+ + L+E
Sbjct: 2515 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2574
Query: 1072 PALGDSEI-----LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE 1126
PA G++ I L+K++ Q +V + SL SV E +++ + E
Sbjct: 2575 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-----------E 2623
Query: 1127 LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD------ 1180
K L + D + +Q++++K L+ +K Q+ E + A+E+ D
Sbjct: 2624 NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA 2683
Query: 1181 FEYKTPDELQKAVEEMKRAKEEAQ-QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETL 1239
+ K LQ + ++ K + K L+ E+ +S + E + +E TL
Sbjct: 2684 YSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL 2743
Query: 1240 TTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEIS 1299
+ C+ L K + + E+ S + + L+ + + E + E I
Sbjct: 2744 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIK 2803
Query: 1300 EVLDSLENLMRHSEDNPNQI--RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRR 1357
L LE LM S DN N+ +LA T ++ I +LE + + +L + A R
Sbjct: 2804 AFLKKLEALMA-SNDNANKTCKMMLATEETSPDLVG--IKRDLEALSKQCNKLLDRAQAR 2860
Query: 1358 QKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMP--QEAQKIQSDLTS 1415
++ +E +I+ +E L +E + K A++ + +Q P E + I L
Sbjct: 2861 EEQVEGTIKRLEEFYSKL---KEFSILLQK------AEEHEESQGPVGMETETINQQLNM 2911
Query: 1416 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 1463
++ +E + QGK+ L Q I A K L DV+ +++ L +K A
Sbjct: 2912 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 2971
Query: 1464 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 1509
+LQE+ + + L +L + S E +VV++Q+ L + L
Sbjct: 2972 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3031
Query: 1510 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 1569
+ KS VE++ + G +I + + ++ ++++ L + L K R +QLE ++
Sbjct: 3032 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3091
Query: 1570 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 1629
++ + + L EWL + L + S L+ ++A KA + +I HL
Sbjct: 3092 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3151
Query: 1630 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1688
+G++LK + +++ +V+ KL +I + ++ LL + + + F ++ +
Sbjct: 3152 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3211
Query: 1689 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 1748
W+ + L S+ + L + ++EL ++ + + + N + ++
Sbjct: 3212 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3269
Query: 1749 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 1796
++ + + AI R K T ++ K LEQ ++L L+ +E E
Sbjct: 3270 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3329
Query: 1797 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 1846
+ + LK E+ + K++ ++ N + + L + + R RE ++
Sbjct: 3330 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3389
Query: 1847 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1906
++ + D +Q+ ++ + Q+ + AD L + + EKKL SL + R E+
Sbjct: 3390 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3449
Query: 1907 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1966
+ +LQ +K + R + + D + S+ ++ K N
Sbjct: 3450 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3505
Query: 1967 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 2026
+ I + E + + L ++ TY + L E + +++ A ++E
Sbjct: 3506 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 3560
Query: 2027 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2086
L +Q+E + +++ + + ID ++ K L +P E +QE D + ++ +
Sbjct: 3561 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3619
Query: 2087 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 2144
K R D ++ + +FH I +Q L E+ + + + P + E K K + E
Sbjct: 3620 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 3676
Query: 2145 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 2197
++ + + Q + TL GEE+I +S TD I +Q+KL + W+ + + +
Sbjct: 3677 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 3736
Query: 2198 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 2256
R+ +L + + +F D ++ +++ + +PG + + K++ E + + EE+
Sbjct: 3737 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 3796
Query: 2257 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 2314
Q L + G ++ + E DK ++ + + N W +++A ++ ++E
Sbjct: 3797 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 3852
Query: 2315 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2371
++ Q + L+ D + L +SPI LE Q +E +++ + +
Sbjct: 3853 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 3908
Query: 2372 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 2431
Q ++E + + + L K K + K ++D E K + L+E
Sbjct: 3909 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 3952
Query: 2432 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 2491
++ ++ KLE +L+ AL F A EL WL+ + ++
Sbjct: 3953 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 3990
Query: 2492 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2551
Q+ + GD + I + K D+ + +E + A +L ++ +EA + +++E
Sbjct: 3991 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4049
Query: 2552 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2611
+ +W V E + R+QQL+ L+ + + E+ +Q L L + K +
Sbjct: 4050 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4109
Query: 2612 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2671
++++ ++ + ++L + N+ W S+
Sbjct: 4110 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4169
Query: 2672 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 2731
+++ER+ LEE L +F L+ F+ WLT+AE T NV A+R +L+ V +
Sbjct: 4170 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4223
Query: 2732 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 2791
+ + E+ +H + LD+ L+ D VL++ L ++ +W ++ ++ +
Sbjct: 4224 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4282
Query: 2792 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 2851
L+ + + K+ H + +L+ WL+ + L + I D ++ Q H+ F++ L
Sbjct: 4283 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4342
Query: 2852 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 2911
K V +T T R L + + L E+ +W
Sbjct: 4343 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4383
Query: 2912 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 2970
+ + S + Q K++E L + +A L L + E QPV GD ID + +
Sbjct: 4384 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4441
Query: 2971 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 3023
++ KA + E+ +V + AR+L S + +++L+TRW+ +
Sbjct: 4442 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4501
Query: 3024 QVAVEDRVRQLHEAH 3038
Q +E +RQ E H
Sbjct: 4502 QTRLEAALRQAEEFH 4516
Score = 325 bits (832), Expect = 7e-88
Identities = 536/2814 (19%), Positives = 1113/2814 (39%), Gaps = 346/2814 (12%)
Query: 330 LMESEVNLDRYQTALEE---VLSWL--LSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMD 384
+ E L + Q A EE ++ WL ++ T Q D E VK Q ++ + +
Sbjct: 2093 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2152
Query: 385 LTAHQGRVGNILQLGSKLIGTGKLSEDEETEV----QEQMNLLNSRWECLRVASMEKQSN 440
L + V + +L KL T L E+ +T ++ + ++S+W+ L ++++Q
Sbjct: 2153 LKQN---VNKVQELKDKL--TELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2207
Query: 441 LHRVLMDLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQ 498
L +L + E L WL + E + PL D L Q QQ ++L ++
Sbjct: 2208 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLG--PLSIDPNMLNTQRQQVQILLQEFAT 2265
Query: 499 EQVRVNSLTHMVVVVDESSGDHAT--AALEEQLKVLGDRWANICRWTEDRWVLLQDILLK 556
+ + LT + G+ + ++EQL + +W ++ DR + ++K
Sbjct: 2266 RKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVK 2325
Query: 557 WQRLTEEQCLFSAWLSEKEDAVNKIHT-----TGFKDQNEMLSSLQKLAVLKADLEKKKQ 611
T+ Q L + + D NK+ + T N+ L + QK+ K +++++K+
Sbjct: 2326 ---STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKM---KQEIQQEKK 2379
Query: 612 SMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ-- 669
+ +L +DL + +K + + + L+ + + ++ QK E + A ++
Sbjct: 2380 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2439
Query: 670 ----------------------PSLTQTTVMETVT-------------------TVTTRE 688
P + V+E++ T+ E
Sbjct: 2440 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2499
Query: 689 QILVKHAQEELPPPPPQ---------------KKRQITVDSEIRKRLDV--DITELHSWI 731
+L+K E Q K+R+ + + K L + L WI
Sbjct: 2500 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 2559
Query: 732 TRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV------- 784
+ + L+ +F + EG S K K ++++E + F ++ + +A +L+
Sbjct: 2560 DKCQNNLEEIKFCLDPAEGENSIAKLK--SLQKEMDQHFGMVELLNNTANSLLSVCEIDK 2617
Query: 785 EQMVNEGVNA-DSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 843
E + +E + + +EQL+S+ +FC L + + E+Q QLQ ++
Sbjct: 2618 EVVTDENKSLIQKVDMVTEQLHSK--KFC-LENMTQKFKEFQEVSKESKRQLQCAKEQLD 2674
Query: 844 TAEN---------WLKIQPTTPSEPTAIKSQLKICKDEVNRL----------SGLQPQIE 884
++ +L + T A+K Q+ + K L S + Q+E
Sbjct: 2675 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE 2734
Query: 885 RLKIQSIALKEK-GQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPM-RYQE 942
+ + L ++ + FL+ HF+ ++ ++ E D++ P+ R E
Sbjct: 2735 TIAQEHSTLSQQVDEKCSFLETKLQGI-GHFQNTIREMFSQFAEFDDELDSMAPVGRDAE 2793
Query: 943 TMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEM 1002
T+ + ++ KL S + + + +E L + ++ +
Sbjct: 2794 TLQKQKETIKAFLKKLEALMAS-------NDNANKTCKMMLATEETSPDLVGIKRDLEAL 2846
Query: 1003 SKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1062
SK+ + R Q+ E++EG K+L E KL+E L+K + H ++
Sbjct: 2847 SKQCNKLLDRA-QAREEQVEGTIKRLE----EFYSKLKEFSILLQKAEEHEES------- 2894
Query: 1063 VDVFLKEEWPALGDSEILKKQLKQCRLLVSD-IQTIQPSLNSVNEGGQK-IKNEAEPEFA 1120
+ P ++E + +QL ++ + I+ +Q VN GQ I++ A+
Sbjct: 2895 -------QGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTST 2947
Query: 1121 SRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD 1180
LE +L ++N +W + ++V R L+ L Q L + WM EE +
Sbjct: 2948 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3007
Query: 1181 FEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLT 1240
++ ++E K + +++ V+++ + A P + + K+L L
Sbjct: 3008 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3067
Query: 1241 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1300
+ ++ L + + + LE + + LE N+WL +E +L E I A ++ E
Sbjct: 3068 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3127
Query: 1301 VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELET-------FNSRWR-ELHE 1352
+ + L +D N + L Q ++ G + L + E + F+ W E+ E
Sbjct: 3128 QIAQHKAL---EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3184
Query: 1353 EAVRRQKLLEQSIQSAQET-EKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK--I 1409
++ R +LL+Q++ +A+ E + L+ DK + D Q+++ +
Sbjct: 3185 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVL 3244
Query: 1410 QSDLTSHEISLEEMKKHNQGKEAAQRVLS-QIDVAQKKLQDVSMKFRLFQKPAN-----F 1463
Q D+ + ++++ + G E ++ ++ + Q KL+ + +++ K +
Sbjct: 3245 QEDILLRKQNVDQALLN--GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3302
Query: 1464 EQRLQESKMI----------LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1513
EQ LQ ++ + LD+V++ L + ET+ ++ E L K K+
Sbjct: 3303 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKA 3362
Query: 1514 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1573
++ + + +++ + L++ V Y + +T++ ++++ + S++
Sbjct: 3363 LLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFD 3422
Query: 1574 KEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEA 1633
+ + W+ T+ +L + +++ K EI + K + + + G
Sbjct: 3423 QAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHK 3482
Query: 1634 LKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWII 1692
+ T ++E ++ KL + N+ + E L Q + F + + + W+
Sbjct: 3483 IMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT 3542
Query: 1693 QADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRGDH 1744
+ +++ E E + QQ+E L+ L AE K++ T Q L G
Sbjct: 3543 ETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS 3602
Query: 1745 CRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ--- 1799
++ + + ++ I +K ++ + + QF+ I ++LE LE +++
Sbjct: 3603 ----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 3658
Query: 1800 --GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIKQQ 1848
++ + E + ++E+ +V + L QRG+ + R K K Q
Sbjct: 3659 PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 3718
Query: 1849 LLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR-D 1904
L + L +R K L++ ++ L+ + D + + L +P D
Sbjct: 3719 KLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 3778
Query: 1905 ERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKFAQ 1961
+K+ + +EE++ ++ + + L + A EP + + K E+ S +
Sbjct: 3779 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDS 3838
Query: 1962 FRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCA 2021
+ +I + EE M + Y + V + L +
Sbjct: 3839 LNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSPIG 3885
Query: 2022 KDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLDFQ 2080
D E + +Q E LK K Q ++ ++ + L+ T ++ +Q+ L +L
Sbjct: 3886 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLI 3945
Query: 2081 WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 2140
W+ + + +RQ + + ++ +F + + WLT E L + Q P + +
Sbjct: 3946 WDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIEIE 4004
Query: 2141 LKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSD 2197
L + LQ+ + Q+ V +N G ++I+ S+ +AS LQ KL LN RWQ V ++
Sbjct: 4005 LAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQ 4064
Query: 2198 RKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLVEE 2255
RK++L+ F ++ + WL + + +AS PL G + KE+L +
Sbjct: 4065 RKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVCAA 4123
Query: 2256 LPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEIEA 2314
++ K L + G +L P S E D+ N LK+ +W V L E++ ++E
Sbjct: 4124 FEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKLEE 4180
Query: 2315 QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI---AV 2368
+ + L+D + WL+ L + ++P+ F + E ++ V
Sbjct: 4181 ALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4233
Query: 2369 QAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDLAP 2425
+ + + E+ G HL + +K +K L + S W K V RL++ R
Sbjct: 4234 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR-------- 4285
Query: 2426 GLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLL 2485
SL F+ AW++L +WL
Sbjct: 4286 ----------------------------------SLDDARKRAKQFHEAWSKLMEWLEES 4311
Query: 2486 DQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI 2545
++ + S+ + D + I + + K + L + + ++LK KTS +
Sbjct: 4312 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4371
Query: 2546 ITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEG 2605
+ D + ++++WD + R+ +L E L S Q+ +A + L + +L +
Sbjct: 4372 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4431
Query: 2606 PYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINAS 2665
+D + I K K+L + ++V A +L+ S DD+ V + + ++
Sbjct: 4432 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELSTR 4490
Query: 2666 WRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERLLE 2722
W ++ ++ LE R ++F + L WL EAE T VL D R L
Sbjct: 4491 WETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLI 4550
Query: 2723 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKW 2782
D KE MK+ ++ + E+ T + + ++ D ++ + + ++
Sbjct: 4551 DQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRARF 4600
Query: 2783 SELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQKQ 2840
E+ + + L ++ L+ LL WLQ + L+ + I + V+
Sbjct: 4601 EEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKAL 4660
Query: 2841 NDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LYQE 2883
H+ F E+ K+P + +T + I + ++ G ++ LY
Sbjct: 4661 IAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPS 4720
Query: 2884 PRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2937
+ E + V L+ K W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 4721 GSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 4766
Score = 316 bits (809), Expect = 3e-85
Identities = 546/2809 (19%), Positives = 1127/2809 (40%), Gaps = 353/2809 (12%)
Query: 337 LDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 396
L+++ E WL +E L+ ++D+ + + + + D+ +H+G + I
Sbjct: 1513 LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT 1572
Query: 397 QLGSKLIGTGKLSEDEE----------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 446
G++++ K + EVQ +++ R+ L +NL ++
Sbjct: 1573 ISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVD 1632
Query: 447 DLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 504
Q+ + L L E K EP+ D ++L+RQ+++ K LQ + +QV V
Sbjct: 1633 KYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE 1692
Query: 505 SLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRWVLLQDILLKWQRLT 561
L V+ ++ G A + Q K L D R+ ++ + +R LQ L + +
Sbjct: 1693 KLKKTAEVLLDARGSLLPAKNDIQ-KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 1751
Query: 562 EEQCLFSAWLSEKEDAVNK-----IHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 616
+ W+ E ++ + +++T +D + K +L+ D+ ++ S+ +
Sbjct: 1752 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQD------IISKNIMLEQDIAGRQSSINAM 1805
Query: 617 YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTT 676
+ + T + S +A + + + + K +++ A++ + T + L +
Sbjct: 1806 NEKVKKFMETT-DPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVE--LFENL 1862
Query: 677 VMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDS-----EIRKRLDVDITELHSWI 731
+ T + T+ Q L + ++P + Q +S E +K L+V LHS +
Sbjct: 1863 SEKLQTFLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHKKHLEV----LHSLL 1915
Query: 732 TR-SEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE 790
S L S + + K N S +KF++++D + +
Sbjct: 1916 KEISSHGLPSDKALVLEKTNNLS--------------KKFKEMEDTIKEKK--------- 1952
Query: 791 GVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK 850
+++ EQL++ F L+ +W++ + E + + E+ K
Sbjct: 1953 ----EAVTSCQEQLDA----FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2004
Query: 851 IQPT----TPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKG--------- 897
+Q TP S + +C + ++ ++ I +K L +G
Sbjct: 2005 LQEKWSLKTPEIQKVNNSGISLC-NLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2063
Query: 898 --QGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQ-S 954
+G + D ++ ++ + ++ + EL T L + QE SA+ W+Q+ +
Sbjct: 2064 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--QKAQEESSAMMQWLQKMN 2121
Query: 955 ETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISR 1012
+T Q TD E ++ ++ + ++ ++ L++ + + L + E+ ++ P + +
Sbjct: 2122 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2181
Query: 1013 KYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 1072
+++ EI+ +W++L+ ++ QKLEE N L + Q LK+W+ E ++ + P
Sbjct: 2182 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2241
Query: 1073 ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA--EPEFASRLETELKEL 1130
D +L Q +Q ++L+ + T +P + GQ I + +P ++ +L +
Sbjct: 2242 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2301
Query: 1131 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1190
+WD + Q+ R + + + K+ Q L + + ++ + + PD +
Sbjct: 2302 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN 2361
Query: 1191 KAVEEMKRAKEEAQQKEAKVKL---LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLC 1247
+ +E ++ K+E QQ++ ++K+ L E +++++ + A+ L ++LE + +++ +
Sbjct: 2362 QQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--LSRQLEGILKSFKDVE 2419
Query: 1248 TRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLEN 1307
+ + L+ A H+ WL+ T + + IS LD LE+
Sbjct: 2420 QKAENHVQHLQSACASSHQFQQMSRDFQAWLD-------TKKEEQNKSHPISAKLDVLES 2472
Query: 1308 LMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1367
L++ +D ++TLT M E E E + + + A++ Q
Sbjct: 2473 LIKDHKD-------FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--------- 2516
Query: 1368 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN 1427
L+ I+ + +KQ+ + K++ SLE+ K+
Sbjct: 2517 -------LNTIKTNWDTFNKQVK-------------ERENKLKE-------SLEKALKY- 2548
Query: 1428 QGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETK 1487
KE + + ID Q L+++ KF L PA E + + K + E+ H +E
Sbjct: 2549 --KEQVETLWPWIDKCQNNLEEI--KFCL--DPAEGENSIAKLKSLQKEMDQHFGMVEL- 2601
Query: 1488 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK-----KQTENPKELDERVT 1542
LN+ N S+ E+ EV V + ++QK +Q + K E +T
Sbjct: 2602 ----------LNNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHSKKFCLENMT 2649
Query: 1543 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1602
+ E+ E K+QL+ C K + + M T++ +++ +
Sbjct: 2650 QKFKEFQEVSK---ESKRQLQ-CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 2705
Query: 1603 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL---VEDKLSLLNSNWIAV 1659
+D K +++ + K ++V ++T+ + TL V++K S L + +
Sbjct: 2706 VDL----AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 2761
Query: 1660 TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE-DVLKRLKA 1718
+ N + E FD +D + A+TL + E K K+ + L
Sbjct: 2762 G----HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 2817
Query: 1719 ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 1778
N + +T + + +L+ + D + + Q ++L R A +++ +K
Sbjct: 2818 NANKTCKMMLATEETSPDLVGIKRD--LEALSKQCNKLLDRAQAREEQVEG-----TIKR 2870
Query: 1779 LEQFNSDIQK---LLEPLEA--EIQQGVNLKEEDFNKDMN----------EDNEGTVKEL 1823
LE+F S +++ LL+ E E Q V ++ E N+ +N E +G +++
Sbjct: 2871 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 2930
Query: 1824 LQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQAD 1883
G L Q + ++ + + L +QR + E +++ +
Sbjct: 2931 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 2990
Query: 1884 DLLKCLDDIEKKLASLPEPRDERKI--------KEIDRELQKKKEELNAVRRQAEGLSED 1935
LL + D E+ +A+ P E K+ K + R L +K + ++R+ E +
Sbjct: 2991 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI--- 3047
Query: 1936 GAAMAVEPT-QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-ISYVP 1993
A EP ++++ K+ ++S++ LN A+ T + LE IS V
Sbjct: 3048 --ATTAEPADKVKILKQLSLLDSRWEAL--LNKAE------------TRNRQLEGISVVA 3091
Query: 1994 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 2053
+ + +++ L +E+ L + L +Q K ++D + + + H
Sbjct: 3092 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL---HQ 3148
Query: 2054 KKTAALQSATPVERVKLQEALSQLDFQ---WEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 2110
+ R S+LDF + ++ + R +++ + F D
Sbjct: 3149 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEV 3208
Query: 2111 IFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQDGIGQRQTVVRTLNATGEEIIQQ 2168
WL E L K + + +K L+ LQ+ I R+ V G E+++Q
Sbjct: 3209 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3268
Query: 2169 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD- 2227
++ + I+Q+KL ++ R++++ K +D K LE+ + E WL++ +
Sbjct: 3269 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3328
Query: 2228 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2287
+ S + K ++ + + K L +E + +L LNE +L P E L
Sbjct: 3329 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG--L 3386
Query: 2288 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2347
E + + N ++ VS + +K EI+A I + + ++ + L W++ +L
Sbjct: 3387 EKMVAEDNERYRLVSDTITQKVEEIDAAIL-------RSQQFDQAADAELSWITETEKKL 3439
Query: 2348 EIYN-----QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK---EKPATQPVKRKL 2399
Q VQ+T + D+ + L K H + Q +K+KL
Sbjct: 3440 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3499
Query: 2400 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2459
+ + + + ++ E R Q + A +LV Q T E L
Sbjct: 3500 DKVLKNYDTICQINSE-RYLQLERAQ-------------SLVNQFWETYEELWPWLTETQ 3545
Query: 2460 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2519
S++ ++PA A L + ++ Q+ + + E+I + K + + +
Sbjct: 3546 SIISQLPAPA--------------LEYETLRQQQE---EHRQLRELIAEHKPHIDKMNKT 3588
Query: 2520 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2579
PQL EL S E +I ++ + +++E ++ R L+E + ST
Sbjct: 3589 GPQLLEL-----------SPGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQST 3636
Query: 2580 QWLEAKEEAEQVLGQARAKLESWKEGPYT---VDAIQKKITETKQLAKDLRQWQTNVDVA 2636
Q+ ++ +Q+L +E ++ P V+ I+++I+E K ++ D+ + Q +
Sbjct: 3637 QF---HDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 3693
Query: 2637 NDLALKLL-RDYSADDTRKVHMITENINAS---WRSIHKRVSEREAALEETHRLLQQFPL 2692
+++ R D + + ++ W +IH V EREA L + L ++F
Sbjct: 3694 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC 3753
Query: 2693 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD-LQGEIEAHTDVYHNL 2751
D + + + + L+D +++ + E +++ D LQ E+ D+ NL
Sbjct: 3754 DHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEEL----DIVINL 3809
Query: 2752 DENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 2811
L + G D ++++ +D +N W L K + LE + + LQ
Sbjct: 3810 GSE----LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 3865
Query: 2812 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 2871
+ W+ + +L+ +PIG D V++Q + + FK E +
Sbjct: 3866 AVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAY------------------Q 3907
Query: 2872 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 2931
Q +E +E+L + L + ++ ++ E+ W+ L + Q K++ L
Sbjct: 3908 QQIE-MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 3966
Query: 2932 LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 2991
L + Q A DEL L E + +PVG +++ L K L+ ++ + V V
Sbjct: 3967 LGQFQHALDELLAWLTHTEGLLSEQKPVGG-DPKAIEIELAKHHVLQNDVLAHQSTVEAV 4025
Query: 2992 NDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 3039
N L NL + LE LN RW+ + E R +QL A R
Sbjct: 4026 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4074
Score = 313 bits (803), Expect = 2e-84
Identities = 505/2706 (18%), Positives = 1066/2706 (39%), Gaps = 308/2706 (11%)
Query: 399 GSKLIGTGKLSEDEE-------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN- 450
G+ L G G + EE T +++ M ++ +E L + +K + L+ L LQ
Sbjct: 2047 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2106
Query: 451 -QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 509
++ + WL K + K ++ P D E +K QV+Q+K + +L+Q +V L
Sbjct: 2107 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2166
Query: 510 VVVVDESSGDHATAALEEQ-LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 568
+ + E + D A +Q L + +W + + T DR L++ + +
Sbjct: 2167 LTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLK 2226
Query: 569 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL- 627
WL EKE V+ + D N + + Q++ +L + +K +L + Q +LS
Sbjct: 2227 QWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2285
Query: 628 KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 687
++ S+ + L + WD+L +L I QA+ + T+
Sbjct: 2286 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS-----------------TQ 2328
Query: 688 EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFR 747
Q L++ ++L +D+++ L V T +A+ Q E A
Sbjct: 2329 YQSLLRSLSDKLSD----------LDNKLSSSLAVS--------THPDAMNQQLETAQKM 2370
Query: 748 KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK-QASEQLNS 806
K+ I++EK + + AQAL E + + V + +K + S QL
Sbjct: 2371 KQ-----------EIQQEKKQ--------IKVAQALCEDL-SALVKEEYLKAELSRQLEG 2410
Query: 807 RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ-----MTTTAENWLKIQPTTPSEPTA 861
F + + N +++ + A +Q QQ+ + + T E K P + ++
Sbjct: 2411 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS-AKLDV 2469
Query: 862 IKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFS 919
++S +K KD L+ E+ + +++ LK +G L ++
Sbjct: 2470 LESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2529
Query: 920 DVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQ 979
V+ RE +L+ + ++Y+E + + W+ + + L + + E E + +L+
Sbjct: 2530 QVKERENKLKESLEKA--LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE-GENSIAKLK 2586
Query: 980 ALQSSLQEQQSGLYYLSTT------VKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLV 1033
+LQ + + + L+ T V E+ K+ ++ ++ + + + + L
Sbjct: 2587 SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLE 2646
Query: 1034 EHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD 1093
QK +E ++ + +Q K+ ++D+ +LG K L +
Sbjct: 2647 NMTQKFKEFQEVSKESKRQLQCAKE---QLDIH-----DSLGSQAYSNKYLTMLQTQQKS 2698
Query: 1094 IQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQWDHMCQQVYARKEALKGGL 1152
+Q ++ ++ Q + EA + + S + +++ + + + QQV + L+ L
Sbjct: 2699 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 2758
Query: 1153 EKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR---------AKEEA 1203
+ Q + EM + ++E + + LQK E +K A +
Sbjct: 2759 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN 2818
Query: 1204 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1263
K K+ L TE + + +K++LE L+ L R + + +E
Sbjct: 2819 ANKTCKMMLATEETSPDLV--------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 2870
Query: 1264 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHS----EDNPNQI 1319
E S L++ + L + E ++ + E I++ L+ + + + +
Sbjct: 2871 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 2930
Query: 1320 RILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI------QSAQE 1370
L Q L + + +L+ N+RW+ L+++ +R L++++ Q A E
Sbjct: 2931 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 2990
Query: 1371 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK 1430
+ S + E L K +A KV AQ+ QE + +Q L + ++E +K+ +
Sbjct: 2991 SLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QEQKLLQRLLDDRKSTVEVIKREGEKI 3047
Query: 1431 EAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI--------LDEVKMHLP 1482
++ + K+L + ++ A R E + L+ + L
Sbjct: 3048 ATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3106
Query: 1483 ALETKSVEQEVVQSQ---LNHCVNLYKSLSEV----KSEVEMVIKTGRQIVQKKQTENPK 1535
+E + V E + +Q L + +K+L + + + G+ + E+
Sbjct: 3107 TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3166
Query: 1536 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1595
+ ++ ++ Y E+ K R + L++ L ++ ++ L WL +L+K S
Sbjct: 3167 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV 3226
Query: 1596 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNS 1654
+ L + + + Q++I +K ++ G E LK G + +++DKL + +
Sbjct: 3227 QDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3286
Query: 1655 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDV 1712
+ +T + + L + + + + W+ ++ + L E++ K ++
Sbjct: 3287 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3346
Query: 1713 L---KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI-- 1767
K LK E + + +DS + ++ L+ R+ +E ++E N R+ +S I
Sbjct: 3347 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3406
Query: 1768 KTGKASIPLKELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED- 1815
K + + +QF+ +KL+ + ++Q + K +
Sbjct: 3407 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3466
Query: 1816 --NEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISH 1873
++ + +L++ G + ++E K + +K K + ++ + + S+R +
Sbjct: 3467 LRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3525
Query: 1874 QWYQYKRQADDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEEL 1922
Q+ ++L L + + ++ LP P + R+++E+ E + +++
Sbjct: 3526 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3585
Query: 1923 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1982
N Q LS G +++ + + +I+ ++ A + + T
Sbjct: 3586 NKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDK 3641
Query: 1983 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 2042
D LE L + +S + ++++ ++ + D E L E+LK + +
Sbjct: 3642 IDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMI 3701
Query: 2043 QSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW 2102
SG D S K +Q+ L Q+ F WE ++ + ++R+ + +E
Sbjct: 3702 ARSGGTDKDISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 3748
Query: 2103 RRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTV 2154
+F D + + + F+R + P + E A+ ++E DG+ + +
Sbjct: 3749 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDI 3805
Query: 2155 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2214
V L G E+I + D I+++ + LN W + K DR +LEE ++Q
Sbjct: 3806 VINL---GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 3862
Query: 2215 DLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV 2273
L W++ A +AS+ + +K+++E++K E +Q +++LN +
Sbjct: 3863 GLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELL 3922
Query: 2274 LVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEE 2331
L EE DK +++ L + L W + + +Q ++E + LGQ + L++L
Sbjct: 3923 LKKVT---EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-- 3977
Query: 2332 QLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQ 2383
L WL+ L Q G E E+A V A Q VE + G
Sbjct: 3978 -----LAWLTHTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGN 4030
Query: 2384 HLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2441
L + + ++ KLE L+ W+ V
Sbjct: 4031 DLIESSAGEEASNLQNKLEVLNQRWQNV-------------------------------- 4058
Query: 2442 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2501
++T K ++ +L F+ +L WL+ ++ + + + + G E
Sbjct: 4059 -----LEKTEQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4109
Query: 2502 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2561
E + E + + L+ Q + + + A T I I ++ +W+ V+
Sbjct: 4110 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVE 4168
Query: 2562 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2621
L R+ +L E L + ++ + ++ L QA L +D + +I E K
Sbjct: 4169 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4228
Query: 2622 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2681
A ++ + + + L D + + ++ + W + +R+ ER +L+
Sbjct: 4229 FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLD 4288
Query: 2682 ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2741
+ + +QF K + WL E+E + + + + D +K + Q ++ Q +
Sbjct: 4289 DARKRAKQFHEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSL 4342
Query: 2742 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSD 2801
A VY + + + +DD + L L + KW + KS+ ++ LE +
Sbjct: 4343 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4402
Query: 2802 QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 2861
+ +LQ L+ WL + +L+ P+ GD V D H+AF++EL +
Sbjct: 4403 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT------ 4456
Query: 2862 LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 2921
++ L + REL E +++ + ++ Q +E++T WE + S
Sbjct: 4457 -------------SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISK 4501
Query: 2922 QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVK 2975
Q +++ L + +E L L +AE + D LID ++ ++K++
Sbjct: 4502 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4561
Query: 2976 ALRGEI 2981
R E+
Sbjct: 4562 EKRAEL 4567
Score = 277 bits (708), Expect = 2e-73
Identities = 491/2725 (18%), Positives = 1089/2725 (39%), Gaps = 258/2725 (9%)
Query: 341 QTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGS 400
Q L+E+L W+ + E +L+ QG++ + ++D + D+ Q + + +
Sbjct: 1751 QDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 1810
Query: 401 KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKELND 458
K + T S + +Q +M L++R+ E + + + ++L ++L
Sbjct: 1811 KFMETTDPST--ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 1868
Query: 459 WL-TKTEERTRKMEEEPLGPDLEDLKRQVQQ-------HKVLQEDLEQEQVRVNSLTHMV 510
+L TKT+ T E + G D+ +L + +Q+ HK + LE + ++
Sbjct: 1869 FLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHK---KHLEVLHSLLKEISSHG 1922
Query: 511 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 570
+ D++ T L ++ K + D + ++ Q+ L +Q L + +W
Sbjct: 1923 LPSDKALVLEKTNNLSKKFKEMEDT----IKEKKEAVTSCQEQLDAFQVLVKS---LKSW 1975
Query: 571 LSEKEDAVNKIHTT-GFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 629
+ E V + + G +D + L +KL + +SLK + + N
Sbjct: 1976 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQ--------------EKWSLKTPEIQKVNN 2021
Query: 630 KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQ--AVTTTQPSLTQTTVMETVTTVTT- 686
++ L N + V K+ A + AV + + T T +T+
Sbjct: 2022 SGIS------LCNLI----SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2071
Query: 687 -REQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL----QSP 741
++ + H E+L K ++ ++ + + + W+ + Q+P
Sbjct: 2072 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2131
Query: 742 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 801
A E + +++ + E E + K+Q+ L+E+ + A KQ
Sbjct: 2132 --APTDTEAVKTQVEQN-KSFEAELKQNVNKVQELKDKLTELLEENPDTP-EAPRWKQML 2187
Query: 802 EQLNSRWIEFCQLLSERLNWLEYQ-NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 860
+++S+W E QL +R LE NN+ F QL+Q E + + +P
Sbjct: 2188 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2247
Query: 861 AIKSQLKICKDEVNRLSGLQPQIERLKIQSIA-LKEKGQGPMF---LDADFVAFTNHFKQ 916
+ +Q + + + + +PQ E+L L G+ P + A T +
Sbjct: 2248 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2307
Query: 917 VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 976
+ + R + + +YQ + ++ + + KLS T + M Q+L
Sbjct: 2308 LTGQLSDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLE 2365
Query: 977 ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSE-ISRKYQSEFEEIEGRWKKLSSQLVEH 1035
Q ++ +Q+++ + +++S E + + + E I +K + + H
Sbjct: 2366 TAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH 2425
Query: 1036 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1095
Q L+ + Q + + W+ + P ++L+ +K + +
Sbjct: 2426 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2485
Query: 1096 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1155
G+ + + + + L+ +L + T WD +QV R+ LK LEK
Sbjct: 2486 AQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 2545
Query: 1156 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTE 1215
+ ++ + + W+ + + E F P E + ++ ++K ++E Q V+LL
Sbjct: 2546 LKYKEQVETLWPWIDKCQNNLEEIKF-CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNN 2604
Query: 1216 SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKAN 1275
+ NS+++ + +E + E ++L + +L+ K LE + + E +++
Sbjct: 2605 TANSLLSVCE-IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESK 2663
Query: 1276 KWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI---LAQTLT----- 1327
+ L + +L +++ G ++ L L+ + + +Q+ + LAQ L
Sbjct: 2664 RQLQCAKEQLDIHDSL-GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD 2722
Query: 1328 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1387
G D L+ ++ET L ++ + LE +Q + ++ + D
Sbjct: 2723 SKGTSDVLL--QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD 2780
Query: 1388 QLAAYIADKVDAAQMPQEAQKIQSDLTSHE----------------ISLEEMKKHNQGKE 1431
+L + DA + ++ + I++ L E ++ EE G +
Sbjct: 2781 ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 2840
Query: 1432 AAQRVLSQ-----IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALET 1486
LS+ +D AQ + + V + ++ F +L+E ++L + + H +
Sbjct: 2841 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE---FYSKLKEFSILLQKAEEHEESQGP 2897
Query: 1487 KSVEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTAL 1544
+E E + QLN K + ++ + + V G+ ++Q ++ + + L+ + +
Sbjct: 2898 VGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDV 2957
Query: 1545 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1604
+ L KV +R QL++ L + + + L W+ T+ + + +
Sbjct: 2958 NARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK 3017
Query: 1605 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRA 1663
+++ K Q+ ++ +K ++ I GE + T + + + +LSLL+S W A+ ++A
Sbjct: 3018 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3077
Query: 1664 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELN 1721
E L + F + ++ + +W+ + L E Q E+ + + KA +
Sbjct: 3078 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3137
Query: 1722 DIRPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL 1776
DI Q+ ++++R D + +V+ ++ F+ + + I+ + S
Sbjct: 3138 DIINHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSR 3189
Query: 1777 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRI 1834
EL Q K+ E E+ +N + +K +D EG K+ + R+
Sbjct: 3190 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRV 3243
Query: 1835 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1894
E + + KQ + Q N L+ L+ + L I + K + D+ K D+ K
Sbjct: 3244 LQE---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3300
Query: 1895 KLASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRW 1952
L + R++ EL K E+ + + + L + A+ A + +L K
Sbjct: 3301 TLEQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEA 3357
Query: 1953 REIESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 2008
+ ++ ++ A + V RE ++ ED V T ++ + A+L
Sbjct: 3358 KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAIL 3416
Query: 2009 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 2068
+Q A D + K+ SL +I+ Q+S ++ + + L+ ++ +
Sbjct: 3417 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3476
Query: 2069 -----KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ------- 2114
K+ A S+ + Q +K++K+ K+ + E++ + + NQ
Sbjct: 3477 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 3536
Query: 2115 ---WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2169
WLTE + + + P E + + ++L++ I + + + +N TG ++++ S
Sbjct: 3537 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 3596
Query: 2170 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADN 2228
SI QEK + + + ++ + + R L+E + ++F +++ + LE +
Sbjct: 3597 PGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 3655
Query: 2229 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDK 2286
+ P + +++KE++ + K + ++ Q + + L + G ++ + + ++
Sbjct: 3656 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 3715
Query: 2287 LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIR 2344
+++KL Q W + + E+ EA++ D+ +L +K +H L++ + +
Sbjct: 3716 VQDKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQ 3766
Query: 2345 NQLEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVK 2396
+ + P + Q+ E A + Q +++ +++ G L +P VK
Sbjct: 3767 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 3826
Query: 2397 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE 2456
+ +++L+S W ++N+ ++ I KLE
Sbjct: 3827 KSIDELNSAWDSLNKAWKD-----------------------------------RIDKLE 3851
Query: 2457 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2516
+ A + + DW+ + + S + DLE + + I + K +
Sbjct: 3852 EA------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 3905
Query: 2517 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2576
Q++ ++E L A+ L K + + + + D + ++ WD ++E + NR+ +L L
Sbjct: 3906 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 3965
Query: 2577 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2636
Q+ A +E L L K AI+ ++ + L D+ Q+ V+
Sbjct: 3966 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4025
Query: 2637 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2696
N L+ + ++ + E +N W+++ ++ +R+ L+ R + F ++E
Sbjct: 4026 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4085
Query: 2697 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2756
WLT+ E + + L + KE + ++ EA + Y +L + Q
Sbjct: 4086 LQQWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQ 4139
Query: 2757 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2816
++L S + + + ++N+ KW + K ++ LE + + H SLQ+ + W
Sbjct: 4140 QMLARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4198
Query: 2817 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQP 2873
L + L+ + V Q D H+ F E+ + I+ +T ++ F +Q
Sbjct: 4199 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4258
Query: 2874 LEGLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQR 2923
+ ++ L + + R + V + L RK+A++ + W KL +W
Sbjct: 4259 VVLIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLE 4309
Query: 2924 KIDETLERLQELQEATDELDLKLRQ 2948
+ +++L+ E+ D++ +L Q
Sbjct: 4310 ESEKSLDSELEIANDPDKIKTQLAQ 4334
Score = 226 bits (576), Expect = 3e-58
Identities = 345/1758 (19%), Positives = 713/1758 (40%), Gaps = 172/1758 (9%)
Query: 328 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 387
+ L E+ ++ R+Q ALE +LSW++ E+ + Q S + +VVK Q + L
Sbjct: 2973 AQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD 3032
Query: 388 HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 447
+ V I + G K+ T + + ++ ++ +Q++LL+SRWE L + + L + +
Sbjct: 3033 RKSTVEVIKREGEKIATTAEPA--DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3090
Query: 448 LQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 505
Q ++ L+ LN+WLT E+R + EP+G L+ Q+ QHK L++D+ + N
Sbjct: 3091 AQQFHETLEPLNEWLTTIEKRL--VNCEPIGTQASKLEEQIAQHKALEDDI----INHNK 3144
Query: 506 LTHMVVVVDES----SGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 561
H V + +S S ++ +L + I + R LLQ L +
Sbjct: 3145 HLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFG 3204
Query: 562 EEQCLFSAWLSEKEDAVNKI-----HTTGFKDQNEMLSSLQKLAVLKAD---------LE 607
E++ WL+E D ++K+ T G Q L LQ+ +L+ LE
Sbjct: 3205 EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLE 3264
Query: 608 KKKQSMGKLYSLKQDLLSTLKNK--------------------------SVTQKTEAWLD 641
KQ+ G + QD L +K + S ++ WLD
Sbjct: 3265 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3324
Query: 642 NF---ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK-HAQE 697
++ V K E+++ + + + +++++ V++ LV A+E
Sbjct: 3325 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRARE 3384
Query: 698 ELPP--PPPQKKRQITVDSEIRKRLDVDITELH------------SWITRSEAVLQSPEF 743
L ++ ++ D+ +K ++D L SWIT +E L S
Sbjct: 3385 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3444
Query: 744 AIFRKEGNFSDLK-EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE 802
++ + L+ +K +E + + + D +S ++ E S+K+ +
Sbjct: 3445 IRLEQDQTSAQLQVQKTFTMEILRHKDI--IDDLVKSGHKIMTACSEE--EKQSMKKKLD 3500
Query: 803 QLNSRWIEFCQLLSERLNWLEYQNNII-AFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 861
++ + CQ+ SER LE +++ F+ ++L T ++ + P E
Sbjct: 3501 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3560
Query: 862 IKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMF-LDADFVAFTNHFKQVFSD 920
++ Q + + ++ +P I+++ L E G F + +VA + Q+ D
Sbjct: 3561 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3620
Query: 921 VQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQA 980
V+ R L ++ + + I +++ +L P + E +++++ E +
Sbjct: 3621 VKKRAVALDEAIS--QSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 3678
Query: 981 LQSSLQEQQSGLYYLSTTVKEM---SKKAPSEISRK-YQSEFEEIEGRWKKLSSQLVEHC 1036
+ +++ Q L +EM S +IS K Q + +++ W+ + + + E
Sbjct: 3679 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 3738
Query: 1037 QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKE-EWPALGDSEILKKQLKQCRLLVSDIQ 1095
KL + M K +L + + F+++ E P + D ++K+Q + + +I
Sbjct: 3739 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI-DPSVVKQQQEAAETIREEID 3797
Query: 1096 TIQPSLNSV-NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1154
+Q L+ V N G + I EP+ ++ + ELN+ WD + + R + L+ ++
Sbjct: 3798 GLQEELDIVINLGSELIAACGEPD-KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 3856
Query: 1155 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1214
V Q L + +W+ A + + +++ +EE+K+ K EA Q++ +++ L
Sbjct: 3857 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 3916
Query: 1215 ESVNSVIAQAPPVA-QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEK 1273
++ + + + ++ L L + L R+ + LE + L++
Sbjct: 3917 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 3976
Query: 1274 ANKWLNEVEFKLKTTENIPGGAEEISEVLDS---LENLMRHSEDNPNQIRILAQTLTDGG 1330
WL E L + + G + I L L+N + + + L +
Sbjct: 3977 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4036
Query: 1331 VMDELIN--EELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1388
+E N +LE N RW+ + E+ +R++ L+ +++ A+ + +Q+ LT ++
Sbjct: 4037 AGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERH 4096
Query: 1389 LAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEE-----MKKHNQ-----GKEAAQR 1435
L A +P+ A++ + ++ + + EE M+K Q K A
Sbjct: 4097 LLA----SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4152
Query: 1436 VLSQIDVAQKKLQDVSMKF--------RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1487
+ I+ ++K + V K F LQ+ L + + L
Sbjct: 4153 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4212
Query: 1488 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLH 1547
S+ + V Q++ ++ + ++ + KTG + Q ++ + + +++
Sbjct: 4213 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4272
Query: 1548 YNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEV 1607
+ ++ ++ ER + L+ K +++ + + L EWL ++ L + P + +++
Sbjct: 4273 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4332
Query: 1608 AWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1665
A K QK + + + G +L KT L ++D LS L W + ++ E
Sbjct: 4333 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4392
Query: 1666 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK-----KKPQQKEDVLKRLKAEL 1720
N L E F + + W+ + + L E + D K + EL
Sbjct: 4393 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4452
Query: 1721 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS--HRIKTGKASIPLKE 1778
V + + A L+ D V+ Q+ EL+ R+ + K + L++
Sbjct: 4453 GKRTSSVQALKRSARELIEGSRDD-SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4511
Query: 1779 LEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1833
E+F+S + LLE L AE +Q GV +ED + + + ++ +K+L ++ L +
Sbjct: 4512 AEEFHSVVHALLEWL-AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKA 4570
Query: 1834 IT------------------------DERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1869
T R E + +Q Q +AL L + +++ L
Sbjct: 4571 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIA--KQELL 4628
Query: 1870 EISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1929
E W Q+ L D +K++ P++ ++K + E Q EE+ +
Sbjct: 4629 EALLAWLQWAETT------LTDKDKEVI----PQEIEEVKALIAEHQTFMEEMTRKQPDV 4678
Query: 1930 EGLSEDGAAMAVEPTQIQ 1947
+ +++ A +P+ +Q
Sbjct: 4679 DKVTKTYKRRAADPSSLQ 4696
Score = 205 bits (521), Expect = 8e-52
Identities = 284/1564 (18%), Positives = 642/1564 (41%), Gaps = 148/1564 (9%)
Query: 264 LHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA-YTQAAYVTTSDPTRSPFPSQHLEAPE 322
++H H Q +++ + + K +S ++Q Y+ + + S
Sbjct: 3140 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCN 3199
Query: 323 DKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYM 382
K FG E EV L + + + LS L + + + + +++ V+++
Sbjct: 3200 AKIFG----EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE--------- 3246
Query: 383 MDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH 442
D+ + V L G +L+ + + DE +Q+++ + +R++ + S + L
Sbjct: 3247 -DILLRKQNVDQALLNGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLE 3303
Query: 443 RVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQ 500
+ L + + +EL WL K E E + L E+ + + K L+++ + +
Sbjct: 3304 QALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG--EEASQAQMRPKELKKEAKNNK 3361
Query: 501 VRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRL 560
++SL + + E A LE+ + +R+ + + + +L+ Q+
Sbjct: 3362 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3421
Query: 561 TEEQCLFSAWLSEKEDA-------------------VNKIHTTGFKDQNEMLSSLQKLA- 600
+ +W++E E V K T +++ L K
Sbjct: 3422 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3481
Query: 601 -VLKADLEKKKQSMGKLYS--LKQ-DLLSTLKNKSVTQ--KTEAWLDNFARCWDNLVQKL 654
++ A E++KQSM K LK D + + ++ Q + ++ ++ F ++ L L
Sbjct: 3482 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 3541
Query: 655 EKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ--EELPPPPPQ------- 705
++ + ISQ P+L T+ + +++ +H +++ PQ
Sbjct: 3542 TETQSIISQLPA---PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3598
Query: 706 -----KKRQITVDS-------EIRKR---LDVDITELHSWITRSEAVLQSPEFAIFRKE- 749
+++ + D+ +++KR LD I++ + + + +L+S E + R
Sbjct: 3599 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 3658
Query: 750 -----GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMV------NEGVNADSIK 798
+KE+++ + + KLQ + + E+M+ ++ ++A +++
Sbjct: 3659 PPSISAEVEKIKEQISENKNVSVD-MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 3717
Query: 799 QASEQLNSRWIEFCQLLSER-LNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 857
+Q+ W L+ ER L+ F+ L +++++
Sbjct: 3718 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 3777
Query: 858 EPTAIKSQLKICKDEVNRLSGLQPQIE---RLKIQSIALKEKGQGPMF---LDADFVAFT 911
+P+ +K Q + + + GLQ +++ L + IA + P+ +D A+
Sbjct: 3778 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 3837
Query: 912 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 971
+ K + E+ +Q ++YQ+ + A+ WV + KL+ TD E +
Sbjct: 3838 SLNKAWKDRIDKLEEAMQAA------VQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 3891
Query: 972 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEFEEIEGRWKKLSS 1030
+Q++ EL+ +S +QQ + L+ + + KK E + Q E++ W L
Sbjct: 3892 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 3951
Query: 1031 QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 1090
+++ KLE + L + Q+ + L W+ + L E+ P GD + ++ +L + +L
Sbjct: 3952 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4011
Query: 1091 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1150
+D+ Q ++ +VN+ G + + E AS L+ +L+ LN +W ++ ++ RK+ L G
Sbjct: 4012 QNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDG 4071
Query: 1151 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKV 1210
L + ++ ++ +W+T E L P+ ++ + + KE
Sbjct: 4072 ALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4131
Query: 1211 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1270
K L + ++A+ P A+ + +++ L ++ + T+LN + LEE E +
Sbjct: 4132 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4191
Query: 1271 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1330
L+ WL + E L + + +D + + QI L +T T
Sbjct: 4192 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4251
Query: 1331 VMDE-----LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI 1385
+ LI L + SRW ++ + V R + L+ + + A++ ++ + E L
Sbjct: 4252 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4311
Query: 1386 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQK 1445
+K L + + ++ + KI++ L H +E +K K + ++ + K
Sbjct: 4312 EKSLDSEL-------EIANDPDKIKTQLAQH----KEFQKSLGAKHSVYDTTNRTGRSLK 4360
Query: 1446 ----------KLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPAL------ 1484
KL D+ + R + K + +L+E+ + + L AL
Sbjct: 4361 EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYR 4420
Query: 1485 -ETKSVEQEVVQSQLNHCVNL-------YKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1536
E + E + V ++ +NL K L + S V+ + ++ R++++ + ++
Sbjct: 4421 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR-DDSSW 4479
Query: 1537 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1596
+ ++ L + + A ++ +LE L+ + + ++ L EWLA + L +
Sbjct: 4480 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4539
Query: 1597 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDKLSLLNSN 1655
L + + K K++E+++ L T +G+ + + T ++ ++++ +
Sbjct: 4540 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4599
Query: 1656 WIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR 1715
+ V + A++ L + + ++ + W+ A+T L + +K+ Q+ + +K
Sbjct: 4600 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 4659
Query: 1716 LKAE 1719
L AE
Sbjct: 4660 LIAE 4663
Score = 178 bits (452), Expect = 8e-44
Identities = 527/2759 (19%), Positives = 1063/2759 (38%), Gaps = 415/2759 (15%)
Query: 452 KLKELNDWLTKTEE--------RTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 503
KLK +N L T+ T+ EEE + D +++ + K + ++++++
Sbjct: 844 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 903
Query: 504 NSLTHMV----VVVDESSGDHATAALE-----EQLKVLGDRWANICRWTEDRWVLLQDI- 553
++L + + DE + L+ E+ L +RW N+ ++R L+ I
Sbjct: 904 HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 963
Query: 554 -LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQS 612
LK+ R T W+ + E KI ++ + + L + +L +++E K+
Sbjct: 964 KSLKYYRDTYHP--LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1021
Query: 613 MGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 672
M + + +T+K+ + T + D+ + K S A Q +
Sbjct: 1022 MDECQKYAEQYSATVKDYELQTMT------YRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075
Query: 673 TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWIT 732
T + T+ T+ +K A + L ++K +++ E ++ ++ EL W++
Sbjct: 1076 DLRTRYTALVTLMTQ---YIKFAGDSLKRLEEEEK---SLEEEKKEHVE-KAKELQKWVS 1128
Query: 733 RSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV 792
L+ E K G K+K+++ E + K +L +A ++ Q + + +
Sbjct: 1129 NISKTLKDAE-----KAGKPPFSKQKISS--EEISTKKEQLSEALQTIQLFLAKHGD--- 1178
Query: 793 NADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ 852
K E+ N L +++ L+ N++ F L+QL++ T+ + +K+
Sbjct: 1179 -----KMTDEERNE--------LEKQVKTLQESYNLL-FSESLKQLQESQTSGD--VKV- 1221
Query: 853 PTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN 912
E + + + K+++ + L Q E I G F+ D
Sbjct: 1222 -----EEKIVAERQQEYKEKLQGICDLLTQTENRLI--------GHQEAFMIGDGTVELK 1268
Query: 913 HFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET--KLSIPQLSVTDYEI 970
+ Q++++ELQ Q + A+ V+ +E K + +LS D +
Sbjct: 1269 KY-------QSKQEELQKDM--------QGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1313
Query: 971 MEQRLGE--LQALQSSLQEQQSGLYY---LSTTVKEMSKKAPS-----EISRKYQSEFEE 1020
+EQ+L E ++ Q +L+ +QS ++T +KE ++K + E K ++ +
Sbjct: 1314 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1373
Query: 1021 IEGRWKKLSSQLVEHCQKLEE-----QMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 1075
+ K +H Q +E+ Q + + + E DV +
Sbjct: 1374 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1433
Query: 1076 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD 1135
++ +K Q ++S Q + + S +K PE +L+ +KEL ++
Sbjct: 1434 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYE 1493
Query: 1136 HMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEE 1195
+ + + E+ D +E W+ Q+E+E + + L ++
Sbjct: 1494 TALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR 1553
Query: 1196 MKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ------------EALKKELETLTTNY 1243
K E+ + ++ +T S N V+ A ++ ++++L+ T +
Sbjct: 1554 QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRF 1613
Query: 1244 QWL---CTRLNGKCKTLEEVWACWHE----LLSYLE----KANKWLNE--------VEFK 1284
+ L C L K L + + + + LL+ L+ A+K L+E ++ +
Sbjct: 1614 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 1673
Query: 1285 LKTTENIPG----------------------------GAEEISEVLDSL----ENLMRHS 1312
L+ T+ + G +I + LD + E+L +
Sbjct: 1674 LEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSV 1733
Query: 1313 EDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEA------------VRRQKL 1360
+ +++I TLT + + ++E L+ + L E+ + + +
Sbjct: 1734 NERNEKLQI---TLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIM 1790
Query: 1361 LEQSIQSAQETEKSLH-LIQESLTFIDKQLAAYIADKVD--AAQMPQEAQKIQSDL---- 1413
LEQ I Q + +++ +++ + D A+ + K+ +A+ + + K + L
Sbjct: 1791 LEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKME 1850
Query: 1414 ---TSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQES 1470
T E+ +K E + L+++DV K + ++S Q +QES
Sbjct: 1851 ELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELS-------------QYMQES 1897
Query: 1471 KMILDEVKMHLPALET--KSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK 1528
E K HL L + K + + S + +LS+ E+E IK ++ V
Sbjct: 1898 TSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTS 1957
Query: 1529 KQTENP-------------KELDERVTALKLHY--NELGAKVTERKQQLEKCLKLSRKMR 1573
Q + KE ++V ++ + +LG + + K+ EK + +++
Sbjct: 1958 CQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ 2017
Query: 1574 KEMN---VLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEV 1630
K N L ++A +AV+ + L+ E G AT E L SI +
Sbjct: 2018 KVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE---GTATNTEEFWANKGLTSIKKD 2074
Query: 1631 GEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 1690
+ L++DK++ LN+ + EE ++ QK +T TKW
Sbjct: 2075 MTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT-------ATKW 2127
Query: 1691 IIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLM--------ANRG 1742
Q ++E K Q +++ K +AEL KV +D+ L+ A R
Sbjct: 2128 --QQTPAPTDTEAVKTQVEQN--KSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRW 2183
Query: 1743 DHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVN 1802
++ + ELN I + K ++S L + + + +++ L +E E+ V
Sbjct: 2184 KQMLTEIDSKWQELNQ--LTIDRQQKLEESSNNLTQFQTVEAQLKQWL--VEKELMVSV- 2238
Query: 1803 LKEEDFNKDMNEDNEGTVKELLQR--------------GDNLQQRITDERKREEIKIKQQ 1848
L + +M V+ LLQ G + R ++ I +K+Q
Sbjct: 2239 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGI-VKEQ 2297
Query: 1849 L--LQTKHNALKDLRSQR---RKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1903
L + K ++L S R +A+ S Q+ R D L LD+ K +SL
Sbjct: 2298 LAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN--KLSSSLAVST 2355
Query: 1904 DERKIKEIDRELQKKKEELNAVRRQ---AEGLSEDGAAMAVEP-TQIQLSKRWREIESKF 1959
+ + QK K+E+ ++Q A+ L ED +A+ E + +LS R++E
Sbjct: 2356 HPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELS---RQLEGIL 2412
Query: 1960 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV---EQLLNA 2016
F+ + + V+ L+ + S +++ QA L+ EQ +
Sbjct: 2413 KSFKDVEQKAENHVQH-----------LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2461
Query: 2017 PDLCAKD-FEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALS 2075
P D E L K K+ +L S + ++ L E+ LQ L+
Sbjct: 2462 PISAKLDVLESLIKDH---KDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLN 2518
Query: 2076 QLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQI---PENW 2132
+ W+ NK K+R+ + S+EK ++ ++ W+ + + L + + P
Sbjct: 2519 TIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG 2578
Query: 2133 EHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC 2192
E++ K LK LQ + Q +V LN T ++ + D ++ ++ SL + V
Sbjct: 2579 ENSIAK--LKSLQKEMDQHFGMVELLNNTANSLL-SVCEIDKEVVTDENKSLIQKVDMVT 2635
Query: 2193 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-------DNIAS----------IPLE 2235
+QL +K LE EFQ E L+ A D++ S + +
Sbjct: 2636 EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 2695
Query: 2236 PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLK--- 2292
Q LK +++ K L ++L + K ++ VL+ +E L ++
Sbjct: 2696 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSD----VLLQVETIAQEHSTLSQQVDEKC 2751
Query: 2293 ---QTNLQWI----KVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRN 2345
+T LQ I R + + E + ++ + + + E L++Q + +L +
Sbjct: 2752 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEA 2811
Query: 2346 QLEIYNQPNQEGPFDVQETEIA-----------------------VQAKQPDVEEILSKG 2382
+ + N+ + E + QA++ VE + +
Sbjct: 2812 LMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRL 2871
Query: 2383 QHLYKEKPATQPVKRKLED-------LSSEWKAVNRLL-----------QELRAKQPD-- 2422
+ Y + + +K E+ + E + +N+ L + L+ KQ D
Sbjct: 2872 EEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVN 2931
Query: 2423 -LAPGLTTIGASPTQTVTLV--TQPVVTKETAISKLEMPSSLMLEVPAL--ADFNRAWTE 2477
L GL A T T L V + ++K + L+ L F A
Sbjct: 2932 WLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALES 2991
Query: 2478 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKT 2537
L W+ ++++ +Q+ + + + I +QK + L+ R+ +E + + + T
Sbjct: 2992 LLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIAT-T 3050
Query: 2538 SNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARA 2597
+ + I ++ + ++W+ + + R +QL + + Q+ E E + L
Sbjct: 3051 AEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEK 3110
Query: 2598 KLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHM 2657
+L + + ++++I + K L D+ ++ A + L S +D V
Sbjct: 3111 RLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQS 3170
Query: 2658 ITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRK 2717
+ + I ++ R L++ + F D + + WL E +
Sbjct: 3171 KLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH---------DKL 3221
Query: 2718 ERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDE---NSQKILRSLEGSDDAVLLQRR 2774
+L + L KQ +L+ E N+D+ N ++L+ G D+ +++Q +
Sbjct: 3222 SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTG-DEVLIIQDK 3280
Query: 2775 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDE-LSRQAPIGGD 2833
L+ + ++ ++ K S ++ LE + +RLH + +EL WL + E LS + +
Sbjct: 3281 LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG 3340
Query: 2834 FPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQP---LEGLEKLYQEPRELPPE 2890
A Q Q + K+E K + ++ S E L P EGLEK+ E
Sbjct: 3341 EEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAE-----DN 3394
Query: 2891 ERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-DLKLRQ 2948
ER + V+ + ++ EE+ + L S + + D L + E ++ L D++L Q
Sbjct: 3395 ERYRLVSDTITQKVEEI----DAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3449
Score = 38.9 bits (89), Expect = 0.095
Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 27/168 (16%)
Query: 2810 LQELLVWLQLKDDELSRQAPIGGDFPAVQKQ----NDVHRAFKR-ELKTKEPVIMSTLET 2864
+Q+LL W+ +L R G D P+V+ +VHRA + E KE I T
Sbjct: 282 VQDLLNWVDEMQVQLDR-TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 340
Query: 2865 VRIFLT-EQPLEGLEKLY--------QEPRELPP----EERAQN-VTRLLRKQAEEVNTE 2910
+ LT + L LE Y + R L RA N + L K+ EEV +
Sbjct: 341 APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYD 400
Query: 2911 WEKLNL-------HSADWQRKIDETLERLQELQEATDELDLKLRQAEV 2951
W + N + A+ R++D+ E ++ +QE ++L L+ A +
Sbjct: 401 WSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 448
>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
[Homo sapiens]
Length = 8797
Score = 320 bits (821), Expect = 1e-86
Identities = 606/3117 (19%), Positives = 1211/3117 (38%), Gaps = 511/3117 (16%)
Query: 7 DEREDVQKKTFTKWVNAQFSKFGKQHI-ENLFSDLQDGRRLLDLLEGLTGQKLPKEKGST 65
DE+E VQK+TFTKW+N+ +K + ++LF D++DG +LL LLE L+GQKLP E+G
Sbjct: 23 DEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGRR 82
Query: 66 --RVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNI 123
R+HA+ N+ AL+ L+ + LVNI STDI DG + LGL+W IIL++Q++ + N+
Sbjct: 83 MKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTSNL 142
Query: 124 -----------------------------MAGLQQTNSEKILLSWVRQSTRNYPQVNVIN 154
+ Q N++K LL WV+ + + V +
Sbjct: 143 PQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQTGIEVKD 202
Query: 155 FTTSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDV 214
F SW G+A +++IH+ RP+L D +V +S + LE AF IA +LGI +LLDPEDV
Sbjct: 203 FGKSWRSGVAFHSVIHAIRPELVDLETVK-GRSNRENLEDAFTIAETELGIPRLLDPEDV 261
Query: 215 DTTYPDKKSILMYITSLFQVLP--QQVSIEAIQEVEMLPRPPKVT-------KEEHFQLH 265
D PD+KSI+ Y+ + P S + ++ E+LP P +E+
Sbjct: 262 DVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVIFK 321
Query: 266 HQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL------- 318
+ +Q L + S+ + +++S+ + + Y H
Sbjct: 322 EMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLSLD 381
Query: 319 EAPEDKSFG---SSLMESEVNLDRYQTA-LEEVLSWLLSAEDTLQAQGEI----SNDVEV 370
+A +S+ S L + + LD+ A L + +WL AE L+ + +
Sbjct: 382 QALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANT 441
Query: 371 VKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECL 430
++ + H+ + + AH+ I + ++ + + D+ ++ E+ + ++S E L
Sbjct: 442 IQRKLEQHKDLLQNTDAHKRAFHEIYR--TRSVNGIPVPPDQLEDMAERFHFVSSTSE-L 498
Query: 431 RVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHK 490
+ ME +R+L L + K L W+ K R E +++ +Q +
Sbjct: 499 HLMKMEFLELKYRLLSLLVLAESK-LKSWIIKYGRR-------------ESVEQLLQNYV 544
Query: 491 VLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTE 544
E+ EQ +V L + ++ G A E +K + + +W N+
Sbjct: 545 SFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEA--ENVMKFMNETTAQWRNLSVEVR 602
Query: 545 DRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKI-----------------HTTGFK 587
+L++++ W R AWL + E +N+ HT
Sbjct: 603 SVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMND 662
Query: 588 DQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARC- 646
N ++ + ++ + DL KQ + L ++L +K + + + + C
Sbjct: 663 AGNFLIETCDEM--VSRDL---KQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCV 717
Query: 647 ----------WDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ 696
L + LE S + + + + VM+ + T+ L+
Sbjct: 718 VTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKES 777
Query: 697 EELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLK 756
P + K S+++++L + E +S + L P + ++ +F D
Sbjct: 778 -----PQEEGKEMFATMSKLKEQL-TKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSL 831
Query: 757 EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLS 816
K+N I + + + AL +Q E + A ++ + + + S
Sbjct: 832 GKINEI--------ITVLEREAQSSALFKQKHQELL-------ACQENCKKTLTLIEKGS 876
Query: 817 ERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRL 876
+ + +N++ ++Q + Q+ + + T +++ ++ K +
Sbjct: 877 QSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK----KF 932
Query: 877 SGLQPQIER-LKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTL 935
+ ++E+ L+I L+EKG L F+ ++V + A K + D L
Sbjct: 933 EESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRV---LNAFLKACDELTDIL 989
Query: 936 PPMRYQETMSAIR----TWVQ-QSETKLSIPQLSVTDYE------IMEQRLGELQALQSS 984
P Q A+R W Q E + L + D E +E+ EL ++
Sbjct: 990 PEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKI-DVEKNRFLASVEECRTELDR-ETK 1047
Query: 985 LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEI-----------------EGRWKK 1027
L Q+ + S K P + K EE+ K+
Sbjct: 1048 LMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKE 1107
Query: 1028 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLK----EEWPALGDSEILKKQ 1083
L + + +KL E +K + + W++ + LK E E+ K+
Sbjct: 1108 LRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV-KRA 1166
Query: 1084 LKQCRLLVS----DIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQ 1139
+++ R V+ + ++ L + E + + + + + ++L + K L T + +
Sbjct: 1167 VEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEK 1226
Query: 1140 QV------YARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAV 1193
+ KE +K LE+ +S K++ E E + E +
Sbjct: 1227 MLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLF----------------- 1269
Query: 1194 EEMKRAKEEAQQKEAKVKLLTESVNSVIAQA-------PPVAQEALKKELETL------- 1239
E ++ QQK ++ V IAQA P E L+K TL
Sbjct: 1270 -EAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSR 1328
Query: 1240 --------TTNYQWLCTRLNGK--CKTLEEVWACWHELLSY--LEKANKWLNEVEFKLKT 1287
T +W N + + L + + LS+ LE + L + + K
Sbjct: 1329 ERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKR 1388
Query: 1288 TENIPGGAE----EISEVLDSLEN---LMRHSEDNPNQIRILAQTLTDGGVMDELINEEL 1340
TE+I AE E SE+ +N L + ++ Q++ L TL + E++ +
Sbjct: 1389 TESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW 1448
Query: 1341 ETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAA 1400
+ F S + L ++K L S+ + + I+ ++ I+ +L++ + + +A
Sbjct: 1449 DHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQ 1508
Query: 1401 QMPQ-----EAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFR 1455
Q E+ +I++ LT EE+++H Q E +L + QK +++ +
Sbjct: 1509 SFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGT--ILGHLSQQQKFEENLR---K 1563
Query: 1456 LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEV 1515
+ Q + FE +L +K+ A ET V QE ++L ++L + S +
Sbjct: 1564 IQQSVSEFEDKLAV------PIKICSSATETYKVLQE--------HMDLCQALESLSSAI 1609
Query: 1516 EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 1575
+ R++V N + AL+ Y ++ + ER+ LE L +++ KE
Sbjct: 1610 TAFSASARKVV------NRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKE 1663
Query: 1576 MNVLTEWLAATDMELTK-RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL 1634
++ WL + + + + ++ E+ +A Q E+ Q + ++ E+L
Sbjct: 1664 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1723
Query: 1635 KTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQ 1693
+V K + +++ L L+ W + + +N L + FD+ + + WI
Sbjct: 1724 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKL 1783
Query: 1694 ADTLLDESEKKKPQQKEDVLKRLK---AELNDIRPKVDSTRDQAA-----------NLMA 1739
+ L + + + L R K AE+ + ++ S + A +L+
Sbjct: 1784 FLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1843
Query: 1740 NRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLE--AEI 1797
+ + C +L E + R A+SH L E Q ++ + +L L E
Sbjct: 1844 GKAEDCFQLFEEASQVVERRQLALSH----------LAEFLQSHASLSGILRQLRQTVEA 1893
Query: 1798 QQGVNLKEED-FNKDMNE--DNEGTVKELLQRGDNL------QQRITDERKREEIKIKQQ 1848
+N E D KD+N+ N ++ D + +I +R +
Sbjct: 1894 TNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATAD 1953
Query: 1849 LLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL--ASLPEPRDE- 1905
L + +++L ++ +A ++ ++ Q ++LLK ++DIE++ L EP +
Sbjct: 1954 QLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQA 2013
Query: 1906 -----RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQ--IQLSKRWREIESK 1958
R +++ EL + EL ++ +A+ +++ A A E + +L W + +
Sbjct: 2014 LQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRL 2073
Query: 1959 FAQFRRLNFAQIHTVREETMMVMTEDMPLEIS---YVPSTYLTEITHVSQALLEVEQLLN 2015
+ + I +RE + LE + V T + + + A + E N
Sbjct: 2074 IHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKN 2133
Query: 2016 APDLCAKDFE--------------------------DLFKQEESLKNIKDSLQQSSGRID 2049
+ KD + D+ + ++ + L+++ R+
Sbjct: 2134 KMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLR 2193
Query: 2050 IIHSKKTAALQSATPVER------VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWR 2103
+ S L + +E ++ E +S LD + ++ K+ + +
Sbjct: 2194 VSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLD-NHLRAEELLKEFESEVKNKALRLE 2252
Query: 2104 RFHYDIKIFNQWLTEAE-----QFLRKTQIPENWEHAKYKWYLKE--LQDGIGQRQTVVR 2156
H + + E QF+ + + + EHAK + + L+D Q V +
Sbjct: 2253 ELHSKVNDLKELTKNLETPPDLQFI-EADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEK 2311
Query: 2157 TLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC---KQLSDRKKRLEEQKNILSEFQ 2213
+N +I +K + S+ +N E C K++ D +K L+ Q++ +S Q
Sbjct: 2312 FIN----DITTWFTKVEESL-------MNCAQNETCEALKKVKDIQKELQSQQSNISSTQ 2360
Query: 2214 RDLNEFVLWLEEAD----------------------NIASIPLEPGKEQQLKEKLEQV-- 2249
+LN A+ + L+ E+ E +++
Sbjct: 2361 ENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQE 2420
Query: 2250 -------------------KLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENK 2290
K+L +L Q IL +++ G + A ++ E Q +
Sbjct: 2421 WFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSD--GQSKLDA-VTQEGQTLYAHL 2477
Query: 2291 LKQ--TNLQWIKVSRALPEKQGEIEAQIKDLGQLE---KKLEDLEEQLNHLLLWLSPIRN 2345
KQ +++Q ++++A E Q ++ +KD L+ +L E+Q L LW+ +
Sbjct: 2478 SKQIVSSIQ-EQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEE 2536
Query: 2346 QLEIYNQPNQEGPFDVQETEI--------AVQAKQPDVEEILSKGQHLYKE--------- 2388
+ N + ++ E+ + A + ++++ +GQ L +E
Sbjct: 2537 RFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGR 2596
Query: 2389 ---------KPATQPVKRKLEDLS---SEWKAVNRLLQEL----RAKQPDLAPGLTTIGA 2432
+ + K KL E +A+ LQ + +A Q LA +T+G+
Sbjct: 2597 LCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGS 2656
Query: 2433 SPT--QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTD---------W 2481
T + ++ + ++ K KL M ++ AL N+ + W
Sbjct: 2657 KDTLEKRLSQIQDILLMKGEGEVKLNM--AIGKGEQALRSSNKEGQRVIQTQLETLKEVW 2714
Query: 2482 LSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLE----------QRRPQLEELITAAQ 2531
++ + +Q + + N+ + ++ Q +E Q +P L+E
Sbjct: 2715 ADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLD 2774
Query: 2532 NLKNKTSNQEARTIITDRI---------------------ERIQNQWDEVQEHLQNRRQQ 2570
+L++ S E T R+ E ++ Q++++ + + ++
Sbjct: 2775 HLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRK 2834
Query: 2571 LNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQ 2630
+ E++KD +L+A E L A+ +L W + A QKK+++ K+L
Sbjct: 2835 VEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGA 2894
Query: 2631 TNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQF 2690
+ + LA ++ ++ +A +H + + A W+ V + ++ LE L+ Q
Sbjct: 2895 SRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLE---NLVSQM 2951
Query: 2691 PLDLEKF---LAWLTEA-ETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEA 2743
L ++F +A L +A E + +L+ ++ LLE +E+++ W Q ++A
Sbjct: 2952 ALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDA 3008
Score = 215 bits (547), Expect = 7e-55
Identities = 376/2031 (18%), Positives = 818/2031 (40%), Gaps = 220/2031 (10%)
Query: 770 FRKLQDASRSAQALVEQMVNEG------VNADSIKQASEQLNSRWIEFCQLLSERLN--- 820
++ L+ + Q + Q++++G ++ ++ QL W+ +S+ L+
Sbjct: 6732 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 6791
Query: 821 -----WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---E 872
W YQ+ + LQ + E W + T P E ++ L + E
Sbjct: 6792 TILKHWTRYQSESADLIHWLQSAKDRL---EFWTQQSVTVPQELEMVRDHLNAFLEFSKE 6848
Query: 873 VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTI- 931
V+ S L+ + Q + LK+ L ++ + + + +++ A +++L +
Sbjct: 6849 VDAQSSLKSSVLSTGNQLLRLKKVDTAT--LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 6906
Query: 932 FDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD---YEIMEQRLGELQALQSSLQEQ 988
D LP + +S + +W+ E + + ++ + Y+ + + L + + + + +
Sbjct: 6907 MDKLPS---RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCK 6963
Query: 989 QSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGR----WKKLSSQLVEHCQKLEEQMN 1044
Q + +++ +V ++S + E R +++F E G W+ L + E Q LE +
Sbjct: 6964 QLTVDFVNQSVLQISSQ-DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 7022
Query: 1045 KLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV 1104
+ +N++Q LK W + LK++ +GD ++ LK C+ L I+ + + +
Sbjct: 7023 SWSEYENNVQCLKTWFETQEKRLKQQH-RIGDQASVQNALKDCQDLEDLIKAKEKEVEKI 7081
Query: 1105 NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSE 1164
+ G + + + +S + + L+EL W ++ V K LK L++ S + +
Sbjct: 7082 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK 7141
Query: 1165 MHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA 1224
++ ++ +A + + +Q V+ ++ +++ +++E ++ N ++ +
Sbjct: 7142 INSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 7201
Query: 1225 PPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1284
P E L L+ + + L + + ++ + + W Y ++ + + E +
Sbjct: 7202 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 7261
Query: 1285 ----LKTTENIPGGAEEISEVLDSLENLMRHS---EDNPNQIRILAQTL---TDGGVMDE 1334
LK N +E++ + +L++ +D+ + L + L D
Sbjct: 7262 TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 7321
Query: 1335 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI- 1393
+ +++L + + L + ++Q L+ + + KSL ++ + ++ L
Sbjct: 7322 IQSDQL-SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7380
Query: 1394 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1453
+ D + + + ++++ + ++ + N E R L D K++Q+++
Sbjct: 7381 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN---ELGYR-LPLNDKEIKRMQNLNRH 7436
Query: 1454 FRLF-----QKPANFEQRLQESKMILDEVKMHLP---------ALETKSVEQEVVQSQLN 1499
+ L ++ + + L + + L++ + + A+E Q +++ Q
Sbjct: 7437 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRA 7496
Query: 1500 HCVNLYKSLSEVKSEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTER 1558
H L+++ + ++ +I G++++++ Q ++ E + ++T L + + + +R
Sbjct: 7497 H--ELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 7554
Query: 1559 KQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD-SEVAWGKATQKE- 1616
+ ++ ++ ++ R+ L +WL ++ S + +P L + + + KE
Sbjct: 7555 RGIIDSQIRQWQRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 7612
Query: 1617 --IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 1674
+ +Q ++ ++ + L + E ++ +L+ + W + + R EE L
Sbjct: 7613 VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL 7672
Query: 1675 KHMETFDQNVDHITKWIIQADTL--LDESEKKKPQQKEDVLKRLKAE---LNDIRPKVDS 1729
K E ++ + AD+L L +KK Q D + L AE ++ V S
Sbjct: 7673 KDWEKCEKGI---------ADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGS 7723
Query: 1730 TRDQAANLMANRGDHCRKLVEPQISELNHR-------FAAISHRIKTGKASIP--LKELE 1780
D L + + IS LN R + + H++ + I L E
Sbjct: 7724 WTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWA 7783
Query: 1781 QF---NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVK-------ELLQRGDNL 1830
F N ++ + L +E+++ Q ++ E+ + + +D + + +L Q G+ L
Sbjct: 7784 VFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERL 7843
Query: 1831 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1890
+ + E K EI+ K + + L DL + R KK E Q + L L
Sbjct: 7844 A-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 7902
Query: 1891 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAA 1938
IE +LA P D +EI R+L +++E + + + G++ D A
Sbjct: 7903 HIESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 7961
Query: 1939 MAVEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVP 1993
E IQ L +RWR I + RRL EET + +
Sbjct: 7962 TDAECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK---------- 8003
Query: 1994 STYLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRID 2049
+L + + L E+ P + E+L K E + + + L Q ++
Sbjct: 8004 --FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LE 8057
Query: 2050 IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI 2109
+I+ + + L++ + + + +W+ + K R + + F
Sbjct: 8058 LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 8117
Query: 2110 KIFNQWLTEAEQFLRKTQIPENWE---HAKYKWYLKELQDGIGQRQTVVRTLNATGEEII 2166
WLTE + L+ T I E AK K LK Q I + + A GE++I
Sbjct: 8118 DSILVWLTEMD--LQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLI 8174
Query: 2167 QQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA 2226
++S DA+I++E+L L QEV ++ K+L L + + DL++ L LE++
Sbjct: 8175 EKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDS 8232
Query: 2227 DNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQD 2285
++ + L L L L Q + + + P V S P+ +
Sbjct: 8233 AALSDLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDY 8289
Query: 2286 KLENKLKQTNLQWIKVSRALP----EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS 2341
L L+ +SRALP E Q + + ++ L LE Q+ L
Sbjct: 8290 DLSRDLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQL----- 8338
Query: 2342 PIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLED 2401
+ + F +Q+TE +++K P E+ + + + L +
Sbjct: 8339 ---------GKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKGYMKLLGE 8379
Query: 2402 LSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK-LEMPSS 2460
SS +V RL +L+ ++ L PG + ++ TQT ++ + + + A+SK L M +
Sbjct: 8380 CSSSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQN 8438
Query: 2461 LMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRR 2520
L +D N W L D L+Q+ + + + D++ I I K K + ++ R+
Sbjct: 8439 LQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQKAVDHRK 8496
Query: 2521 PQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQ 2580
+ + + + ++E+R + DR+ ++ +WD V L+ R +L+D+
Sbjct: 8497 AIILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----GLLQDALM 8550
Query: 2581 WLEAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLRQWQTNVD 2634
+ E L ++ K +D+ +Q + Q+ +L + Q V
Sbjct: 8551 QCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVA 8610
Query: 2635 VANDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 2681
D++ +LL + D KVH+I + + + + + E E L+
Sbjct: 8611 SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 8661
Score = 195 bits (496), Expect = 6e-49
Identities = 525/2901 (18%), Positives = 1111/2901 (38%), Gaps = 392/2901 (13%)
Query: 329 SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQ--GEISNDVEVVKDQFHTHEGYMMDLT 386
+L + L ++ ++ W+ E+ + GE + K++ H E ++ +L
Sbjct: 2509 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2568
Query: 387 AHQGRVGNILQLGSKLIGTGKLSEDE----ETEVQEQMNLLNSRWECLRVASMEKQSNLH 442
A + + + Q G L G + E + NLL E LR + Q H
Sbjct: 2569 AARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQE--H 2626
Query: 443 RVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPD-LEDLKRQVQQHKVLQEDLEQEQV 501
L + L+ + W+ ++R E D LE Q+Q +++ + E V
Sbjct: 2627 EAL----EEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE---V 2679
Query: 502 RVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 561
++N SS ++ QL+ L + WA+I + L+ ++ +W
Sbjct: 2680 KLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYV 2739
Query: 562 EEQCLFSAWLSEKEDAVNKI--HTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL 619
E + W+ + + G K++ +L LQ + ++ E +++ +L +
Sbjct: 2740 ERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSIL---SEAEDHTRALHRLIAK 2796
Query: 620 KQDLLSTLKNKS----VTQKTEAWLDNFARCWDNLVQKLEK----------STAQISQAV 665
++L +++S ++ + ++ ++K+E+ + + + +
Sbjct: 2797 SRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWL 2856
Query: 666 TTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDIT 725
+ + L + + M ++ T ++ +K + + R ++ E+++
Sbjct: 2857 HSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGC 2916
Query: 726 EL-HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV 784
EL H+ + A + E ++F+ + +L ++ E+E + + +L+ A AL+
Sbjct: 2917 ELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALL 2976
Query: 785 EQMVN-----EGVNADS------------------IKQASEQLNSRWIEFCQLLSERLNW 821
+ EG N D + +E L S+ E C+ + +
Sbjct: 2977 KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY 3036
Query: 822 LEYQNNIIAFYNQL------------QQLEQMTTTA----ENWLKIQPTT-------PSE 858
+ +I YN L Q L+Q A + WL T P
Sbjct: 3037 SGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQN 3096
Query: 859 PTAIKSQLKICKDEVNRLSGLQPQIERLK-----IQSIALKEKGQGPMFLDADFVAFTNH 913
+ + + L+ ++ ++ Q ++ + + ++ KEK +G + A A
Sbjct: 3097 ISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKG---IQAKVTAAKED 3153
Query: 914 FKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQ 973
+K S++ +E L+ + + ++ + I+ W+ S+T+ + + S Y++ +
Sbjct: 3154 WKNFHSNLHQKESALENL--KIQMKDFEVSAEPIQDWL--SKTEKMVHESSNRLYDLPAK 3209
Query: 974 RLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPS-----EISRKYQSEFEEIEGRWKKL 1028
R E Q LQS L+E ++ + + +KA S+ ++ ++ ++ L
Sbjct: 3210 RR-EQQKLQSVLEE----IHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLAL 3264
Query: 1029 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1088
S+ E +L+ + + + I+ L+ WM + L D +L + +
Sbjct: 3265 SNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLE 3324
Query: 1089 LLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEAL 1148
L+S Q + + + G+ + PE ++ +L+ + W + K L
Sbjct: 3325 ALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQL 3384
Query: 1149 KGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE- 1207
+G L K S Q + + WM D ++ + E +R E + K
Sbjct: 3385 EGALSKWTSYQDGVRQFSGWM-----------------DSMEANLNESERQHAELRDKTT 3427
Query: 1208 --AKVKLLTESVNSV--------IAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1257
K KLL E V S + A + EL+ L Y+ + R
Sbjct: 3428 MLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKS 3487
Query: 1258 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1317
E++ E L+ WL + + KL + G A L L+ L H +
Sbjct: 3488 EKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQA 3547
Query: 1318 QIRILAQTLTD--GGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1375
+ + T D + + + LE+ W+ Q L ++ L
Sbjct: 3548 LLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAY-------QHRLSETRTQFNNVVNKL 3600
Query: 1376 HLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQR 1435
L+++ +D+ L A + + QS+ + EI L +MKK ++ A +
Sbjct: 3601 RLMEQKFQQVDEWLKT-------AEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRD 3653
Query: 1436 VLSQIDV-AQKKLQDVSMKFRLFQKPANFEQRLQESKM-ILDEVKMHLPALETKSVEQEV 1493
+ ++ AQ+ L + + R+ + R Q + +L+++K +++ +
Sbjct: 3654 EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3713
Query: 1494 VQSQLNHCVNLYKSLSEVKSEVEMV--------IKT---------------------GRQ 1524
+ S + + +K+ V ++++ V +KT G +
Sbjct: 3714 LSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER 3773
Query: 1525 IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 1584
V+ + + L + + EL + V + LEK L L+++ + LT+W+A
Sbjct: 3774 AVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIA 3833
Query: 1585 ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL 1644
L + ++++ K+ Q+ + + +KS+ E GEAL ++ ++
Sbjct: 3834 EYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELV--QDVT 3891
Query: 1645 VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQ------ADTLL 1698
++DK+ L S++ + S +E + L K E ++ + + KW++Q A LL
Sbjct: 3892 LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLL 3951
Query: 1699 DESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNH 1758
+ S + Q+ K + E+ ++++ + + L+ DH + ++L
Sbjct: 3952 ETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQ-------AKLKQ 4004
Query: 1759 RFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKE-----EDFNKDMN 1813
A K ++I S Q++ + LE E+Q+ V+ ++ + + +
Sbjct: 4005 NVHAHLQGTKDSYSAI--------CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQ 4056
Query: 1814 EDNEGTVKELLQRGDNLQQ----RITDERKREEIKIKQQLLQTKHNAL----KDLR---- 1861
D E + + L R + ++Q R E+ R + + + + ++ KD++
Sbjct: 4057 PDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQ 4116
Query: 1862 --SQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDE----------RKIK 1909
Q+ +A ++ W + K +L L D +++L ++ E ++K
Sbjct: 4117 TIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVK 4176
Query: 1910 EIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQ 1969
+ ++LQ K+ +N + + L++ +E + + LN
Sbjct: 4177 DFVKKLQSKQASVNTIIEKVNKLTK------------------KEESPEHKEINHLNDQW 4218
Query: 1970 IHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV--EQLLNAPD-LCAKDFED 2026
+ R+ + + + L+ T H ++EV E+ D L D E
Sbjct: 4219 LDLCRQSNNLCLQREEDLQ--------RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4270
Query: 2027 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2086
E+LK + +LQ+ I+ + +K ++ ++ ++E S L+ +W ++
Sbjct: 4271 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLED 4330
Query: 2087 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQD 2146
+ K + SV + F + + AE+ Q P E K Q+
Sbjct: 4331 LIK---RKIQVSVTNLEELNVVQSRFQELMEWAEE-----QQPNIAEALKQSPPPDMAQN 4382
Query: 2147 GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQK 2206
+ + L A ++++ +S DA + LG LN R Q + K LSD + +
Sbjct: 4383 LLMDHLAICSELEA--KQMLLKSLIKDADRVMADLG-LNER-QVIQKALSDAQSHVNCLS 4438
Query: 2207 NILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKL---EQVKLLVEELPLR---- 2259
+++ + ++ LN+ + E+ + ++ + QQ + K+ E + LL +++ +
Sbjct: 4439 DLVGQRRKYLNKAL--SEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTC 4496
Query: 2260 ---QGILKQL-NETGGPVLVSAPISPE--EQDKLE--NKLKQTNLQWIKVSRALPEKQGE 2311
Q LK NE G + E EQ+K E KL++ + V + + E
Sbjct: 4497 KSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQE 4556
Query: 2312 IEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2371
+E K+L + ED ++ + WL Q +I P EI + +
Sbjct: 4557 LE---KNLVSRKHFKEDFDKACH----WL----KQADIVTFP-----------EINLMNE 4594
Query: 2372 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQE-----LRAKQPDLAPG 2426
++ L+K Q++ ++ P + + L L + + L E L K L
Sbjct: 4595 SSELHTQLAKYQNILEQSPEYENL---LLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQ 4651
Query: 2427 LTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPA-LADFNRAWTELT--DWLS 2483
I A V + ++ ++ S +E+ + + E+ A ++ T+L + LS
Sbjct: 4652 FNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALS 4711
Query: 2484 LLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRP-QLEELITAAQNLKNKTSNQEA 2542
L D + G E ++E+ K++ + +P ++ L+T LK +T
Sbjct: 4712 LQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTE---- 4767
Query: 2543 RTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESW 2602
R+ +++ QEH + QQL LK KEE +V + E
Sbjct: 4768 -----QRVSLLEDTTSAYQEH-EKMCQQLERQLK------SVKEEQSKVNEETLPAEEKL 4815
Query: 2603 KEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENI 2662
K ++Q K++ L ++D LA + R ++ ++T
Sbjct: 4816 KMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLD---PLAYEKARHQIQSWQGELKLLTS-- 4870
Query: 2663 NASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWL--TEAETTANVLQDATRKERL 2720
+I + V+E E+ + ++ F ++ + L WL +AE + V D L
Sbjct: 4871 -----AIGETVTECESRMVQS----IDFQTEMSRSLDWLRRVKAELSGPVYLDL----NL 4917
Query: 2721 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2780
+ + ++++ +++Q + + H E K + L +D L+ L ++
Sbjct: 4918 QDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTK-AKELISAD----LEHSLAELSE 4972
Query: 2781 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 2840
++++ ++ L Q +R + Q WL+ EL + A G D + ++
Sbjct: 4973 LDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLE-DAQELLQLAGNGLDVESAEEN 5031
Query: 2841 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPL---EGLEKLYQEPRELPPEERAQNVT 2897
H F T++ + E + T PL G E L Q+ L E R+Q ++
Sbjct: 5032 LKSHMEF---FSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASL--ELRSQRMS 5086
Query: 2898 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQ 2957
R Q + + ++ D+Q+ +E +E + + ++ KL + ++K S
Sbjct: 5087 RDSGAQVDLL----QRCTAQWHDYQKAREEVIELMNDTEK-------KLSEFSLLKTSSS 5135
Query: 2958 PVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDL 3016
++ L + KAL + E + + + A QL G S LS ++ +
Sbjct: 5136 -------HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTV 5188
Query: 3017 NTRWKLLQVAVEDRVRQLHEA 3037
RW L+ +D+ + L +A
Sbjct: 5189 WQRWTRLRAVAQDQEKILEDA 5209
Score = 192 bits (489), Expect = 4e-48
Identities = 415/2214 (18%), Positives = 873/2214 (39%), Gaps = 377/2214 (17%)
Query: 413 ETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKM-- 470
E ++++ L ++ L + ++S L++ L L++Q + L D E KM
Sbjct: 6553 EQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLT-LKSQYERALQDLADLLETGQEKMAG 6611
Query: 471 EEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV--VVDESSGDHATAALEEQ 528
+++ + E++++ + +HK + LE + +L ++ V + + H T + +
Sbjct: 6612 DQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFH-TELMAQA 6670
Query: 529 LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKD 588
VL + R V L+ IL W L E+Q S L E ++ + G +
Sbjct: 6671 SAVL--------KRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSV---GLVE 6719
Query: 589 QNE--MLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLK----NKSVTQKTEAWLDN 642
+NE ++ + LK+ L + + + ++ + LL ++ + Q E WL N
Sbjct: 6720 ENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSN 6779
Query: 643 -------------FARCWD-------NLVQKLEKSTAQIS----QAVTTTQP-------- 670
+ W +L+ L+ + ++ Q+VT Q
Sbjct: 6780 TNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHL 6839
Query: 671 -------------SLTQTTVMETVTTVTTREQILVKHAQEELP-------------PPPP 704
S +++V+ T + +++ + EL P
Sbjct: 6840 NAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQ 6899
Query: 705 QKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEG--NFSDLKEKVNAI 762
+K Q+ +D + I+E+ SWI+ E V+Q E I G + +K
Sbjct: 6900 EKLHQLQMDKLPSRHA---ISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGF 6956
Query: 763 EREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE--QLNSRWIEFCQLLSERL- 819
+ + K + ++S + Q V E +D A + +N W L++E++
Sbjct: 6957 KIDINCKQLTVDFVNQSVLQISSQDV-ESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQ 7015
Query: 820 -------NWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDE 872
+W EY+NN+ Q L+ T E LK Q + ++++ LK C+D
Sbjct: 7016 LLEGLLESWSEYENNV-------QCLKTWFETQEKRLK-QQHRIGDQASVQNALKDCQDL 7067
Query: 873 VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIF 932
+ + + ++E+++ +AL + + + + ++ Q ++++ +L+ +
Sbjct: 7068 EDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTLRELGQTWANLDHMVGQLKILL 7125
Query: 933 DTLPPM--RYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS 990
++ ++ I +++ ++ LS +L E ++ ++ LQ LQ L++Q+
Sbjct: 7126 KSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQER 7185
Query: 991 GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQ 1050
L + ++ K+ ++ + +E+ RW L ++ E Q + + ++ +
Sbjct: 7186 SLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYK 7245
Query: 1051 NHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQ----LKQCRLLVSDIQTIQPSLNSVNE 1106
++ + + + + E A + +I + ++ C L+ + T++ SL ++E
Sbjct: 7246 DYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHE 7305
Query: 1107 GGQKIKNEAEPEFASRLETELKELNTQWDHMC---QQVYARKEALKGGLEKTVSLQKDLS 1163
G+++K + + AS ++++ L+ H+C Q + ++ +L+ G+ + K L
Sbjct: 7306 LGEQLKQQVDASAASAIQSDQLSLS---QHLCALEQALCKQQTSLQAGVLDYETFAKSLE 7362
Query: 1164 EMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1222
+ W+ +AEE +D + + +Q+ +EE+K + + L E +
Sbjct: 7363 ALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE-----LG 7417
Query: 1223 QAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN-EV 1281
P+ + +K+ ++ L ++ + ++ + L+ + H+ ++LEK W+ V
Sbjct: 7418 YRLPLNDKEIKR-MQNLNRHWSLISSQTTERFSKLQS-FLLQHQ--TFLEKCETWMEFLV 7473
Query: 1282 EFKLKTTENIPGGAEEISE---VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDEL--I 1336
+ + K I G + + E + + M + + I I Q L + G +D+
Sbjct: 7474 QTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEF 7533
Query: 1337 NEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTF------------ 1384
N +L +++W+ + A +R+ +++ I+ Q + +++ L
Sbjct: 7534 NLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSV 7593
Query: 1385 -IDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAA-QRVLSQIDV 1442
I Q A + D+V + Q+ S + + E + + + G EAA Q L++I
Sbjct: 7594 PIPLQQARTLFDEVQFKEKVFLRQQ-GSYILTVEAGKQLLLSADSGAEAALQAELAEI-- 7650
Query: 1443 AQKKLQDVSMKFRLFQKPANF--------EQRLQESKMILDEVKMHLPALETKSVEQEVV 1494
Q+K + SM+ +K F E+ + +S L K L ++ E +
Sbjct: 7651 -QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS--QSLPDHHEEL 7707
Query: 1495 QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAK 1554
++ C L ++ ++ + + ++ L+ERV L+ + EL +
Sbjct: 7708 HAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQ 7767
Query: 1555 VTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRS--AVEGMPSNLDSEVAWGKA 1612
++ R+QQ+ + L ++ L EWL + ++++ +E M L K
Sbjct: 7768 LSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK------KD 7821
Query: 1613 TQKEIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLL 1671
Q+EI + + + ++GE L K K + +E KL +N W + + L
Sbjct: 7822 YQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLK 7881
Query: 1672 EYQKHMETFDQNVDHITKWIIQADTLL-----------DESEKKKPQQKE---------- 1710
E ++ D+N+ + W+ ++ L +E ++K +Q+E
Sbjct: 7882 ETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHST 7941
Query: 1711 ---DVLKRLKAELND-----IRPKVDSTRDQAANLMANRGDHCRKLVEPQI--------- 1753
VL + L+D + DS + NL + C +E ++
Sbjct: 7942 GVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLW 8001
Query: 1754 ----------------SELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEI 1797
SE F + S I T A LK+ E F + + L LE
Sbjct: 8002 QKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT-VAKEELKKFEAFQRQVHECLTQLEL-- 8058
Query: 1798 QQGVNLKEEDFNKDMNEDNEGTVKELL----QRGDNLQQRITD----------------- 1836
+N + ++ D+ ++K+++ QR DNLQ+R+T
Sbjct: 8059 ---INKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFET 8115
Query: 1837 ---------------------------ERKREEIKIKQQLLQTKHNALKDLRSQRRK--- 1866
+ K +++K QQ + HN ++ + +Q +
Sbjct: 8116 ARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIE 8175
Query: 1867 -----KALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK-- 1919
A I + + +R ++ ++ KKL LP P DE + + + EL+
Sbjct: 8176 KSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAAL 8235
Query: 1920 EELNAVRRQAEGL--SEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREET 1977
+L+ R A+ L + + +++ Q S+R L + + + +
Sbjct: 8236 SDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDL 8295
Query: 1978 MMVMTEDMPLE-----------------ISYVPSTYLTEITHVSQAL----LEVEQLLN- 2015
M+ +P E +S S ++I + +AL +++Q N
Sbjct: 8296 ESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENI 8355
Query: 2016 -------APDL-------------CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKK 2055
P+L C+ + + + E LK ++SL G ++ +HS +
Sbjct: 8356 IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESL---PGFVN-LHSTE 8411
Query: 2056 TAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQW 2115
T Q+A ++R WE + ++ R ++++KW++F+ D+ W
Sbjct: 8412 T---QTAGVIDR-------------WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAW 8455
Query: 2116 LTEAEQFLRKTQIPE-----NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSS 2170
L + E+ L + Q E + K LKELQ + R+ ++ ++N E Q S
Sbjct: 8456 LGDTEEELEQLQRLELSTDIQTIELQIK-KLKELQKAVDHRKAIILSINLCSPEFTQADS 8514
Query: 2171 KTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIA 2230
K ++ LQ++L +N RW VC L + + L++ F + +L LE D
Sbjct: 8515 K-ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRK 8573
Query: 2231 S--IPLEPGKEQQ-LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2287
+ +P++ + + L++ +Q+ + EL Q + L + +LV+A E D L
Sbjct: 8574 NEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA----EGTDCL 8629
Query: 2288 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS 2341
E K K + L E+ IK+L +KL D+ L W S
Sbjct: 8630 EAKEKVH-----VIGNRLKLLLKEVSRHIKEL----EKLLDVSSSQQDLSSWSS 8674
Score = 179 bits (453), Expect = 6e-44
Identities = 534/2830 (18%), Positives = 1094/2830 (38%), Gaps = 372/2830 (13%)
Query: 378 HEGYMMDLTAHQGRVGNILQLGSKLIGTGKL-SEDEETEVQEQMNLLNSRWECLRVASME 436
H+ ++++L Q +G + Q ++ G + EE + +++ + R CL +
Sbjct: 5254 HDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR--CLNMQEKV 5311
Query: 437 KQSNLHRVLMDLQNQKLKE-----LNDWLTKTEERTRK--MEEEPLGPDLEDLKRQVQQH 489
K +N V +L+++++ E + W+ +T+E +E + +L+ L + H
Sbjct: 5312 K-TNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNH 5370
Query: 490 KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 549
+ E + +EQ + L ++ E S A AL+ +++ D+ + + E
Sbjct: 5371 RQNIEKMAEEQ-KEKYLGLYTILPSELSLQLAEVALDLKIR---DQIQDKIKEVEQSKAT 5426
Query: 550 LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK- 608
Q++ + Q+L ++ L K D V + T E+ KL L A ++K
Sbjct: 5427 SQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKF 5486
Query: 609 ----------KKQSMGKLYSLKQDLLSTLKNK-SVTQKTEAWLDNFARCWDNLVQKLEK- 656
+ +GKL L Q + +N+ S + + L+ + + +++ +EK
Sbjct: 5487 LEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKA 5546
Query: 657 -----------STAQISQAVTTTQPSLTQ-----------TTVMETVTTVTTREQILVKH 694
S +Q+ + Q L + T ++ +T+V E++ +
Sbjct: 5547 KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQV 5606
Query: 695 AQ-----EELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKE 749
A+ EEL + + + ++ K+ + ++ +L + + +++A L SPE +
Sbjct: 5607 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5666
Query: 750 GNFSDLKEKVNAIE--REKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 807
S + ++ +E + K + + Q A R + +V + A +++ + +L
Sbjct: 5667 EQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA-ALRLQEEASRLQHT 5725
Query: 808 WIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLK 867
I+ C ++ + ++Y+ + +++ L+Q+ A ++ +P S +++Q+
Sbjct: 5726 AIQQCNIMQAAV--VQYEQ----YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQIS 5779
Query: 868 ICKDEVNRLSGLQPQIERL--KIQSIALKEK--------------GQGPMFLDADFVAFT 911
++ ++ G Q QI L K + + +K K +G LD + +
Sbjct: 5780 RHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTP 5839
Query: 912 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 971
+ V R L L P+ + + + S ++ TD +
Sbjct: 5840 SAHPSVVMMTAGRCHTL------LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV- 5892
Query: 972 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQ 1031
Q + QAL + + + + ST+ + + E S ++ +++ W+ L +
Sbjct: 5893 NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT--AKLGDLQRSWETLKNV 5950
Query: 1032 LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLV 1091
+ E + L E + + +K Q+ +Q++ M +++ L E P G S + Q+ + + L+
Sbjct: 5951 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSES-PEPGRSP--ESQMAEHQALM 6007
Query: 1092 SDIQTIQPSLNSVNEG-GQKIKNE---AEPEFASRLETELKELNTQWDHMCQQVYARKEA 1147
+I +Q +N + +++ +E A+P L++ L L + + + +++
Sbjct: 6008 DEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQL 6067
Query: 1148 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1207
L+ L + Q+ + + +A+E + T L A+ K + Q
Sbjct: 6068 LEEKLNDQLEEQRQEQALQRYRCEADEL---DSWLLSTKATLDTALSPPKEPMDMEAQLM 6124
Query: 1208 AKVKLLTESVNSVIAQAP-PVAQEALKKELETLTTNYQWLCTRLNGKCKTLE----EVWA 1262
+L E V+A + V E L E + T + +L GK + L+ E+
Sbjct: 6125 DCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDE---AEQLAGKLRRLKGSLLELQR 6181
Query: 1263 CWHELLSYLEKANKWLNEVEFKLKTTENIPGGAE---------------------EISEV 1301
H+ ++ + E + L T++ PG E E+ +
Sbjct: 6182 ALHDKQLNMQGTAQEKEESDVDLTATQS-PGVQEWLAQARTTWTQQRQSSLQQQKELEQE 6240
Query: 1302 LDSLENLMRHSEDNPNQIRI---LAQTLTDGGVMDELINEEL----------ETFNSRWR 1348
L ++L+R +I I A+T D G +++++EL + +W
Sbjct: 6241 LAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWE 6300
Query: 1349 ELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK 1408
LH+E +QKLL+ ++ QE Q + ++ L+ K D Q+
Sbjct: 6301 SLHQEFSTKQKLLQNVLEQEQE--------QVLYSRPNRLLSGVPLYKGDVP--TQDKSA 6350
Query: 1409 IQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQ 1468
+ S L + EE+ + G + I + QK VS + E+RL
Sbjct: 6351 VTSLLDGLNQAFEEVSSQSGGAKR-----QSIHLEQKLYDGVSATSTWLD---DVEERLF 6402
Query: 1469 ESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK 1528
+ +L E ET QE+ L K + E+ E++ Q
Sbjct: 6403 VATALLPE------ETETCLFNQEI----------LAKDIKEMSEEMDKNKNLFSQAF-P 6445
Query: 1529 KQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDM 1588
+ +N +++ + L + L + V +R Q+++ L+ + ++ VL LA
Sbjct: 6446 ENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKY 6505
Query: 1589 ELTKRSA--VEGMPSNLDSEVAWGKATQKEIEKQKVHLK---SITEVGEALKTVLGKKET 1643
+ ++ A E + + + KE + + LK +V + L K +
Sbjct: 6506 IILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQD 6565
Query: 1644 LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK 1703
+ ++ + ++ S S + L L +Y++ ++ AD L EK
Sbjct: 6566 MYDELMMIIGSR----RSGLNQNLTLKSQYERALQDL-------------ADLLETGQEK 6608
Query: 1704 KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI-------SEL 1756
QK ++ K E+ + K + M RK++ + +EL
Sbjct: 6609 MAGDQK--IIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTEL 6666
Query: 1757 NHRFAAISHRIKTGKASIPLK-------ELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFN 1809
+ +A+ R K + L+ L++ ++ + LE +E+ I V L EE N
Sbjct: 6667 MAQASAVLKR--AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI-PSVGLVEE--N 6721
Query: 1810 KDMNEDNEGTVKELLQRGDNLQQR---ITDERKREEIKIKQQLLQTKHNALKDLRSQRRK 1866
+D D + L + Q + + D+ KR I I L+++ N L +
Sbjct: 6722 EDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTN 6781
Query: 1867 KALEISHQ-------WYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK 1919
K + H+ W +Y+ ++ DL+ L + +L + + + +EL+ +
Sbjct: 6782 KMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ-----QSVTVPQELEMVR 6836
Query: 1920 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 1979
+ LNA ++ + + + + S Q RL T+R E
Sbjct: 6837 DHLNAFLEFSKEVDAQSSLKS-------------SVLSTGNQLLRLKKVDTATLRSELSR 6883
Query: 1980 VMTEDMPLEISYVPSTYLTEITHVSQ--------ALLEVEQLLNAPDLCAKDFEDLFKQE 2031
+ ++ L ++ +P+ + E H Q A+ EV ++ + + ED K
Sbjct: 6884 IDSQWTDL-LTNIPA--VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNS 6940
Query: 2032 ESLKNIKDSLQQSSG-RIDIIHSKKT------AALQ-SATPVE-----RVKLQEALSQLD 2078
K I + LQ+ G +IDI + T + LQ S+ VE + E L ++
Sbjct: 6941 IGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMN 7000
Query: 2079 FQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYK 2138
W+ + + ++ + +E W + +++ W E+ L+ Q + A +
Sbjct: 7001 KSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLK--QQHRIGDQASVQ 7058
Query: 2139 WYLK---ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQL 2195
LK +L+D I ++ V + G +IQ + +SI+ L L W + +
Sbjct: 7059 NALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMV 7118
Query: 2196 SDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVE 2254
K L+ + S + ++ +L EA +++ L G + ++ +++ ++ L +
Sbjct: 7119 GQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQD 7178
Query: 2255 ELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 2314
+L ++ L++ +L P + L N LK+ N++W L E+ E
Sbjct: 7179 DLEKQERSLQKFGSITNQLLKEC--HPPVTETLTNTLKEVNMRW----NNLLEEIAEQLQ 7232
Query: 2315 QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP-FDVQETEIAVQAKQP 2373
K L QL ++ +D +Q S ++ Q + N+ + D+ + E+A +
Sbjct: 7233 SSKALLQLWQRYKDYSKQC------ASTVQQQEDRTNELLKAATNKDIADDEVATWIQ-- 7284
Query: 2374 DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 2433
D ++L KG K+ L +L + K Q++ A AS
Sbjct: 7285 DCNDLL-KGLGTVKDSLFF------LHELGEQLK------QQVDAS-----------AAS 7320
Query: 2434 PTQTVTL-VTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQ 2492
Q+ L ++Q + E A+ K + +SL V F ++ L W+ +++++ Q
Sbjct: 7321 AIQSDQLSLSQHLCALEQALCKQQ--TSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQ 7378
Query: 2493 RVM-VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2551
DL I E + + K M P L+ L L +++E + R++
Sbjct: 7379 DPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL--PLNDKEIK-----RMQ 7431
Query: 2552 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2611
+ W + R +L L +LE E + L Q KL G Y
Sbjct: 7432 NLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLL 7491
Query: 2612 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2671
Q++ E Q RQ + + + +LL DD + ++ ++ W+ + +
Sbjct: 7492 EQQRAHELFQAEMFSRQQILHSIIID--GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIR 7549
Query: 2672 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVLQDATRKERLLEDSKGV 2727
R +R ++ R Q++ EK WL E + + ++ R L D
Sbjct: 7550 RAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQF 7609
Query: 2728 KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRK 2787
KE K + QG Y E +++L S + +A LQ L + KW
Sbjct: 7610 KE--KVFLRQQGS-------YILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKWKSASM 7659
Query: 2788 KSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAF 2847
+ + L W++ + + L L+ +LS+ P ++H
Sbjct: 7660 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP--------DHHEELHAEQ 7711
Query: 2848 KRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEV 2907
R + + V T + ++ L + L A +++ +L ++ E +
Sbjct: 7712 MRCKELENAVGSWTDDLTQLSLLKDTLSAYIS-------------ADDIS-ILNERVELL 7757
Query: 2908 NTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSL 2967
+WE+L + +++I E L E EL L Q E GD+LI+ +
Sbjct: 7758 QRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQNGDILIEEM 7814
Query: 2968 QDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDLNTRWKLLQVA 3026
+ L+ K + EIA +EN + + +L + + L +N RW+ L
Sbjct: 7815 IEKLK--KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL 7872
Query: 3027 VEDRVRQLHE 3036
+ RV++L E
Sbjct: 7873 IAARVKKLKE 7882
Score = 179 bits (453), Expect = 6e-44
Identities = 528/2863 (18%), Positives = 1102/2863 (38%), Gaps = 393/2863 (13%)
Query: 329 SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAH 388
+L E+ +YQ +L+ + + + + E L E E Q H+ M ++
Sbjct: 5957 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILML 6013
Query: 389 QGRVGNILQ-LGSKLIGTG-KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 446
Q + + L +L+ + E+ +Q + +L R +R+ + K+ L L
Sbjct: 6014 QDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN 6073
Query: 447 DL-----QNQKLK-------ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE 494
D Q Q L+ EL+ WL T+ P P D++ Q+ + +
Sbjct: 6074 DQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP--MDMEAQLMDCQNMLV 6131
Query: 495 DLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDIL 554
++EQ+ V ++ L+ V +E+ A +++ + L + L+ L
Sbjct: 6132 EIEQKVVALSELS----VHNENLLLEGKAHTKDEAEQLAGKLRR-----------LKGSL 6176
Query: 555 LKWQR-LTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEML------------SSLQKLAV 601
L+ QR L ++Q EKE++ + T E L SSLQ+
Sbjct: 6177 LELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE 6236
Query: 602 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT------------------QKTEAWLDNF 643
L+ +L ++K + + S +++L + +K+ A D
Sbjct: 6237 LEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE-DQM 6295
Query: 644 ARCWDNLVQK-------LEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILV---- 692
W++L Q+ L+ Q + V ++P+ + V V T+++ V
Sbjct: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL 6355
Query: 693 ---KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL--------QSP 741
A EE+ KRQ + ++L ++ +W+ E L +
Sbjct: 6356 DGLNQAFEEVSSQSGGAKRQ---SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6412
Query: 742 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 801
E +F +E D+KE +++ K + +QA E N V D++
Sbjct: 6413 ETCLFNQEILAKDIKEMSEEMDKNK----------NLFSQAFPENGDNRDVIEDTLGCLL 6462
Query: 802 EQLN---SRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN-WLKIQPTTPS 857
+L+ S + C + ERL I+ F N L+ L T+ A+N ++ +Q
Sbjct: 6463 GRLSLLDSVVNQRCHQMKERLQ------QILNFQNDLKVL--FTSLADNKYIILQKLANV 6514
Query: 858 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV 917
+ Q++ + + L I LK + L+ + L + + ++
Sbjct: 6515 FEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSK----LQDMYDEL 6570
Query: 918 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 977
+ +R L + +Y+ + + ++ + K++ D +I+ E
Sbjct: 6571 MMIIGSRRSGLNQ--NLTLKSQYERALQDLADLLETGQEKMA------GDQKIIVSSKEE 6622
Query: 978 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1037
+Q L +E GL + + +K S +K E+ + +S +++
Sbjct: 6623 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ----ASAVLKRAH 6678
Query: 1038 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG----DSEILKKQLKQCRLLVSD 1093
K ++ + + +H+ ++ ++ ++ P++G + + L ++ + L S
Sbjct: 6679 KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSS 6738
Query: 1094 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLE 1153
+ QP L V + G+++ S LE++L +L W ++ L+ L+
Sbjct: 6739 LNEYQPKLYQVLDDGKRLLISIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILK 6795
Query: 1154 KTVSLQKDLSEMHEWMTQAEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVK 1211
Q + +++ W+ A++ E+ + P EL+ + + E +++ +A+
Sbjct: 6796 HWTRYQSESADLIHWLQSAKDRLEFWTQQ-SVTVPQELEMVRDHLNAFLEFSKEVDAQSS 6854
Query: 1212 LLTE--SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLS 1269
L + S + + + V L+ EL + + + L T + + L ++
Sbjct: 6855 LKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRH 6914
Query: 1270 YLEKANKWLNEVEFKL-KTTENIPG--GAEEISEVLDSLE------NLMRHSEDNPNQ-- 1318
+ + W++ +E + K +NI G + I E L + N + + D NQ
Sbjct: 6915 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 6974
Query: 1319 IRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLI 1378
++I +Q + E+L N W+ L + +LLE ++S E E ++ +
Sbjct: 6975 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 7034
Query: 1379 QESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV 1436
+ +K+L I D+ ++ Q ++ + + E +E+++++
Sbjct: 7035 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNG--------- 7085
Query: 1437 LSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRLQESKMILD---------------- 1475
+ + Q K +DVS L Q AN + + + K++L
Sbjct: 7086 ---LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKI 7142
Query: 1476 -----EVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1530
E + L + E VQ Q+++ NL L + + ++ Q++++
Sbjct: 7143 NSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 7202
Query: 1531 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR---KEMNVLTEWLAATD 1587
+ L + + + +N L ++ E+ Q + L+L ++ + K+ +
Sbjct: 7203 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 7262
Query: 1588 MELTKRSAVEGMPSNLDSEVA-WGKATQ---KEIEKQKVHLKSITEVGEALKTVLGKK-- 1641
EL K + + + D EVA W + K + K L + E+GE LK +
Sbjct: 7263 NELLKAATNKDIA---DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAA 7319
Query: 1642 ETLVEDKLSLLNSNWIAVTSRAEEWLNL---LLEYQKHMETFDQNVDHITKWIIQADTLL 1698
+ D+LSL + ++ +L +L+Y ETF ++++ + WI++A+ +L
Sbjct: 7320 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY----ETFAKSLEALEAWIVEAEEIL 7375
Query: 1699 D------ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 1752
S+ Q++ + LK + + + P +D + L N + R
Sbjct: 7376 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKR------ 7429
Query: 1753 ISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNK-- 1810
+ LN ++ IS + T + S L Q + ++K +E +Q L E
Sbjct: 7430 MQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQ 7488
Query: 1811 ---DMNEDNEGTVKELLQRGDNLQQRITDERK---------REEIKIKQQLLQTKHNALK 1858
+ +E E+ R L I D ++ R+E +K LL + +
Sbjct: 7489 HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI 7548
Query: 1859 DLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE----KKLASLPEPR-------DERK 1907
QRR QW +Y+ A+ L K L ++ L S+P P DE +
Sbjct: 7549 RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ 7608
Query: 1908 IKEIDRELQKKKEELNAVRRQAEGLSED-GAAMAVEPTQIQLSKRWREIESKFA-QFRRL 1965
KE Q+ L + LS D GA A++ ++ ++W+ + Q ++L
Sbjct: 7609 FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL 7668
Query: 1966 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 2025
F ++ E I+ T +SQ+L + + L+A + K+ E
Sbjct: 7669 AF----------LLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELE 7718
Query: 2026 DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN 2085
+ ++ + D L Q S D + +A SA + L E + L QWE++
Sbjct: 7719 N------AVGSWTDDLTQLSLLKDTL-----SAYISADDISI--LNERVELLQRQWEELC 7765
Query: 2086 KMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ---IPENWEHAKYKWYLK 2142
R+ + + +W F K +WLT+ E + + I E E K K
Sbjct: 7766 HQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK-----K 7820
Query: 2143 ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRL 2202
+ Q+ I Q L GE + + S ++ AS ++ KLG +N RWQ + ++ R K+L
Sbjct: 7821 DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKL 7880
Query: 2203 EEQKNILSEFQRDLNEFVLWLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ 2260
+E + + ++++ WL ++ + P+ + ++++ KL + + L ++
Sbjct: 7881 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 7940
Query: 2261 -GILKQLNETGGPVLV---SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2316
G+ LN VL+ A + E D ++ + + +W + E++ +IE
Sbjct: 7941 TGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE--- 7995
Query: 2317 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2376
+ +L +K D + WL + F I AK+
Sbjct: 7996 -ETWRLWQKFLDDYSRFED---WLK----------SSERTAAFPSSSGVIYTVAKE---- 8037
Query: 2377 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPT 2435
E + +R++ + ++ + +N+ + L R + D A L +
Sbjct: 8038 -----------ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 8086
Query: 2436 QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2495
Q + + V T+I + L + +F A + WL+ +D ++ +
Sbjct: 8087 QRWDNLQKRV----TSILR-----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIE 8135
Query: 2496 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2555
D+ I + KA Q++ ++E++I + L K+ +A II + ++ ++
Sbjct: 8136 HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRR 8194
Query: 2556 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2615
EV ++ ++L + + + E E A + L ++ + Q
Sbjct: 8195 YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 8254
Query: 2616 ITETKQLAKDLR-----------------QWQTNVDVANDLALKLLRDYSADDTRKVHMI 2658
+ LA+ LR +W + D++ DL + R ++D
Sbjct: 8255 SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG---- 8310
Query: 2659 TENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKE 2718
++ + +S +ALE R L + LD +F + + T N+++ T
Sbjct: 8311 -QDDKDFYLRGAVGLSGDHSALESQIRQLGK-ALDDSRF-----QIQQTENIIRSKTPTG 8363
Query: 2719 RLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNM 2778
L+ S K + L GE + D L+ ++ SL G + + + +
Sbjct: 8364 PELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGV 8417
Query: 2779 NFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSR--QAPIGGDFPA 2836
+W L+ ++L+ ++ + +W++ + L + WL ++EL + + + D
Sbjct: 8418 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 8477
Query: 2837 VQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNV 2896
++ Q + ++ + ++ +I+S F E
Sbjct: 8478 IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE--------------------- 8516
Query: 2897 TRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSW 2956
+R L+ + ++N W+++ +W+ + + L + Q E + L L L + K
Sbjct: 8517 SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEI 8576
Query: 2957 QPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL 2998
P+ +L + LQDH +++ ++ E+ + V+ + D++ QL
Sbjct: 8577 VPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL 8619
Score = 176 bits (446), Expect = 4e-43
Identities = 365/2049 (17%), Positives = 798/2049 (38%), Gaps = 282/2049 (13%)
Query: 339 RYQTALEEVLSWLLSAEDTL----QAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 394
RYQ+ +++ WL SA+D L Q + ++E+V+D + + ++ A +
Sbjct: 6799 RYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSS 6858
Query: 395 ILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDL--QNQK 452
+L G++L+ +L + + ++ +++ ++S+W L Q LH++ MD
Sbjct: 6859 VLSTGNQLL---RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA 6915
Query: 453 LKELNDWLTKTEERTRKMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 511
+ E+ W++ E +K E+ + + +Q++K + D+ +Q+ V+ + V+
Sbjct: 6916 ISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVL 6975
Query: 512 VV---DESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 568
+ D S EQL + W + ++ LL+ +L W
Sbjct: 6976 QISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLK 7035
Query: 569 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLK 628
W +E + + H G DQ + ++L+ L+ DL K K+ ++ ++Q+ L+ ++
Sbjct: 7036 TWFETQEKRLKQQHRIG--DQASVQNALKDCQDLE-DLIKAKEK--EVEKIEQNGLALIQ 7090
Query: 629 NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 688
NK +S V +T L QT + + +
Sbjct: 7091 NKK---------------------------EDVSSIVMSTLRELGQT--WANLDHMVGQL 7121
Query: 689 QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRK 748
+IL+K ++ ++ D +++ + E ++R + S E A+ +
Sbjct: 7122 KILLKSVLDQ------WSSHKVAFD-----KINSYLMEARYSLSRFRLLTGSLE-AVQVQ 7169
Query: 749 EGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRW 808
N +L++ + EK E R LQ L+++ +++ +++N RW
Sbjct: 7170 VDNLQNLQD-----DLEKQE--RSLQKFGSITNQLLKEC--HPPVTETLTNTLKEVNMRW 7220
Query: 809 IEFCQLLSERLN--------WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 860
+ ++E+L W Y++ + +QQ E T LK
Sbjct: 7221 NNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT---NELLKAATNKDIADD 7277
Query: 861 AIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEK--GQGPMFLDADFVAFTNHFKQVF 918
+ + ++ C D + L ++ + L LK++ + +D ++ + H +
Sbjct: 7278 EVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALE 7337
Query: 919 SDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLS-VTDYEIMEQRLGE 977
+ ++ LQ L + +++ A+ W+ ++E L S +D +++R+ E
Sbjct: 7338 QALCKQQTSLQA--GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEE 7395
Query: 978 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1037
L+ L L+ E+ + P ++ K + + W +SSQ E
Sbjct: 7396 LKGQMLKFSSMAPDLDRLN----ELGYRLP--LNDKEIKRMQNLNRHWSLISSQTTERFS 7449
Query: 1038 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 1097
KL+ + + + +T +++ + + L E G+ + L +Q + L +++ +
Sbjct: 7450 KLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMFSR 7507
Query: 1098 QPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVS 1157
Q L+S+ GQ++ + + + +L L+ QW + ++ R+ + + +
Sbjct: 7508 QQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQR 7567
Query: 1158 LQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKA---VEEMKRAKEEAQQKEAKVKLLT 1214
++ ++ +W+ E YL P LQ+A +E++ ++ +++ L
Sbjct: 7568 YREMAEKLRKWL--VEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTV 7625
Query: 1215 ESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHE----LLSY 1270
E+ ++ A A+ AL+ EL + ++ RL + K L + W + +
Sbjct: 7626 EAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADS 7685
Query: 1271 LEKANKWLNEVEFKLKTTENIPGGAEEISEV---LDSLENLMRHSEDNPNQIRILAQTLT 1327
LEK FK K ++++P EE+ LEN + D+ Q+ +L TL+
Sbjct: 7686 LEKLR------TFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7739
Query: 1328 DGGVMDE--LINEELETFNSRWREL-HEEAVRRQKLLEQSIQSAQETEKSLH-------- 1376
D+ ++NE +E +W EL H+ ++RRQ++ E+ + A +EK+
Sbjct: 7740 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7799
Query: 1377 ----------LIQESLTFIDKQLAAYIA----DKVDAAQMPQEAQKIQSDLTSHEISLEE 1422
LI+E + + K IA +K+ QM + K SHE E
Sbjct: 7800 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAK-----ASHESKASE 7854
Query: 1423 MK-KHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHL 1481
++ K + + Q +L I KKL++ + + ++ + + L ++ L
Sbjct: 7855 IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ------QLDKNMSSLRTWLAHIESEL 7908
Query: 1482 -PALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK----KQTENPKE 1536
+ S E +Q +LN L + + + + V V+ ++
Sbjct: 7909 AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDS 7968
Query: 1537 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1596
+ + L + + A ER+ ++E+ +L +K + + +WL +++ S+
Sbjct: 7969 IQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSS 8028
Query: 1597 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLL---- 1652
+ + E+ +A Q+++ + L+ I + L +E + SL
Sbjct: 8029 GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL-----ARENRTDSACSLKQMVH 8083
Query: 1653 --NSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE 1710
N W + R L L + E F+ D I W+ + D L E +
Sbjct: 8084 EGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQ 8143
Query: 1711 DVLKRLKA---ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI 1767
+K+LKA E++ K++ Q L+ ++E ++ EL + R+
Sbjct: 8144 AKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRV 8203
Query: 1768 KTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRG 1827
+ + L D L E E++ L + ++ D + D+ + +
Sbjct: 8204 ERYHKKLIRLPLPDDEHD----LSDRELELEDSAALSDLHWH-DRSADSLLSPQPSSNLS 8258
Query: 1828 DNLQQRITDERKREEIKIKQQLLQTK----HNALKDLRSQRRKK---------------- 1867
+L Q + ER + + + ++ +DL S +
Sbjct: 8259 LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 8318
Query: 1868 --ALEISHQWYQYKRQADDLLKCLDD-----------IEKKLASLPEPRDERK------- 1907
A+ +S + Q L K LDD I K + PE K
Sbjct: 8319 RGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLG 8378
Query: 1908 --------IKEIDRELQKKKE------ELNAVRRQAEGLSE-----DGAAMAVEPTQIQL 1948
+K ++ +L++++E L++ Q G+ + A++ E Q
Sbjct: 8379 ECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQN 8438
Query: 1949 SKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 2008
++W++ S +A + EE + ++ +I + + ++ + +A+
Sbjct: 8439 LQKWQQFNSDLNSI----WAWLGDTEEELEQLQRLELSTDIQTI-ELQIKKLKELQKAVD 8493
Query: 2009 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 2068
+ ++ + +LC+ +F +E ++++D L Q +GR
Sbjct: 8494 HRKAIILSINLCSPEFTQADSKES--RDLQDRLSQMNGR--------------------- 8530
Query: 2069 KLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK--- 2125
W++V + ++ +G ++ + + FH ++ + L E R+
Sbjct: 8531 ------------WDRVCSLLEEWRGLLQDALMQCQGFH---EMSHGLLLMLENIDRRKNE 8575
Query: 2126 -TQIPENWEH---AKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKL 2181
I N + + L +++ + + Q V +L +++ + TD +EK+
Sbjct: 8576 IVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKV 8635
Query: 2182 GSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQ 2241
+ R + + K++S K LE+ ++ S Q+DL+ + +E D S+ G+
Sbjct: 8636 HVIGNRLKLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS-ADELDTSGSVSPTSGRSTP 8693
Query: 2242 LKEKLEQVK 2250
++K + K
Sbjct: 8694 NRQKTPRGK 8702
Score = 172 bits (435), Expect = 7e-42
Identities = 533/3032 (17%), Positives = 1167/3032 (38%), Gaps = 426/3032 (14%)
Query: 353 SAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL--------QLGSKLIG 404
S E+ + E+ E + D + E + L HQ + I Q+ G
Sbjct: 1244 SLEELISGSKEVQEQAEKILDTENLFEAQQL-LLHHQQKTKRISAKKRDVQQQIAQAQQG 1302
Query: 405 TGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELN-DWLTKT 463
G L + E++ L S + L S E+Q R+ + L+ + E N + + +
Sbjct: 1303 EGGLPD----RGHEELRKLESTLDGLE-RSRERQER--RIQVTLRKWERFETNKETVVRY 1355
Query: 464 EERTRKMEEEPLG-PDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESS----G 518
+T E L LE L +++Q K + E V+ +L V E+S G
Sbjct: 1356 LFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENL------VKEASEIPLG 1409
Query: 519 DHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAV 578
L++Q K + ++ + E+ ++ + KW S W++EKE +
Sbjct: 1410 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1469
Query: 579 NKIHTTGFKDQNEMLSSLQKLAVLKAD--------LEKKKQSMGKLYSLKQDLLSTLKNK 630
N + T+ +M S K+ + + + LE++ QS + + + K
Sbjct: 1470 NALETSS--SAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLT 1527
Query: 631 SVTQKTEAWLDNFARCWDNLV-------QKLEKSTAQISQAVTTTQPSL----------T 673
+ + E L A+C + + QK E++ +I Q+V+ + L T
Sbjct: 1528 QIRRYGEE-LREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSAT 1586
Query: 674 QT-----------TVMETVTTVTT------REQILVKHAQEELPPPPPQ--------KKR 708
+T +E++++ T R+ + +E Q K+R
Sbjct: 1587 ETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKER 1646
Query: 709 QITVDSEIR--KRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIERE- 765
Q +++ + +RL+ +++ +W+ R EA SPE I + + A++ E
Sbjct: 1647 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEV 1706
Query: 766 --KAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLE 823
+A + KL S ++ + + +K EQL+ RW + Q++++R+N+L+
Sbjct: 1707 VSQASFYSKLLQLKESLFSVASKD-----DVKMMKLHLEQLDERWRDLPQIINKRINFLQ 1761
Query: 824 YQNNIIAFYNQLQQLEQMTTTAENWLKI---QPTTPSEPTAIKSQLKIC--KDEVNRLSG 878
+++A + QQ +++ + W+K+ + T SE + + Q+ + KD +
Sbjct: 1762 ---SVVA---EHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVES 1815
Query: 879 LQPQIERLKIQSIALKEKGQGP--MFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLP 936
+ +++ L+ L G+ L F++ V+ R+ L + + L
Sbjct: 1816 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFL- 1874
Query: 937 PMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLS 996
+ ++S I ++Q T + ++ + +++E+ L + +L+ L +
Sbjct: 1875 --QSHASLSGILRQLRQ--TVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGIL 1930
Query: 997 TTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTL 1056
+ + K SE ++ +++ G +++ + L + + + Q+ + L
Sbjct: 1931 SKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEEL 1990
Query: 1057 KKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAE 1116
K + +++ +E + L+++L+ L ++ + + L + + ++I + +
Sbjct: 1991 LKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIA-QKD 2049
Query: 1117 PEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEY 1176
FA ++ E+ L WD + ++ + G ++ Q S + + + A
Sbjct: 2050 VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVI 2109
Query: 1177 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ---EALK 1233
+ R K ++L+ A + + AK + K+ + T ++++ + +K
Sbjct: 2110 VTRT-TIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVK 2168
Query: 1234 KELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN----EVEFKLKTTE 1289
++E+ + + +L L + W ++LS ++ W N ++ + +
Sbjct: 2169 TDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLD 2228
Query: 1290 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1349
N E + E ++N E+ +++ L + + +L E +
Sbjct: 2229 NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHA 2288
Query: 1350 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAA-----QMPQ 1404
V + L + + QS Q EK ++ I T +++ L ++ A + +
Sbjct: 2289 KEITEVAKGTLKDFTAQSTQ-VEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQK 2347
Query: 1405 EAQKIQSDLTSHEISLEEM--KKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPA- 1461
E Q QS+++S + +L + K H+ E+ R ++ + + + + K + + +
Sbjct: 2348 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2407
Query: 1462 --NFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVI 1519
+F + +QE + K ++ + +V++++L+ N+ S+S+ +S+++ V
Sbjct: 2408 EKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2467
Query: 1520 KTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVL 1579
+ G+ + + + E++T + + + KQ L+ C + L
Sbjct: 2468 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
Query: 1580 TEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 1639
W+ E+ +R E NL + E+ K ++ L + E+L +
Sbjct: 2528 NLWI----HEMEERFNTE----NLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQ 2579
Query: 1640 KKETLVEDK----------LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITK 1689
+ + L E+ LL S+ + E+ + + Q+H E ++ + +
Sbjct: 2580 RGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEH-EALEEALQSMWF 2638
Query: 1690 WIIQADTLLDESEKKKPQQKEDVLKRLKAELNDI-------RPKVDSTRDQAANLMANRG 1742
W+ L +E +D L++ +++ DI K++ + + +
Sbjct: 2639 WVKAIQDRLACAE--STLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSN 2696
Query: 1743 DHCRKLVEPQISELNHRFAAIS----HRIKTGKASIP-----LKELEQFNSDIQKLLEPL 1793
+++++ Q+ L +A I H T ++ I ++ Q ++ + + +
Sbjct: 2697 KEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI 2756
Query: 1794 EAEIQQGVNLKEEDFNKD-------MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIK 1846
E +Q LKE+ D ED+ + L+ + L ++ DE ++
Sbjct: 2757 EHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKD---TA 2813
Query: 1847 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1906
Q+ L+T+ N + + ++ +K EI D L LD
Sbjct: 2814 QEELKTQFNDIMTVAKEKMRKVEEI----------VKDHLMYLD---------------- 2847
Query: 1907 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1966
+ E L KEEL+ + +S D +A TQ +LSK I+S+ RL+
Sbjct: 2848 AVHEFTDWLHSAKEELH----RWSDMSGDSSA-----TQKKLSKIKELIDSREIGASRLS 2898
Query: 1967 FAQ--IHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDF 2024
+ V++ T E M E+ + + + V Q +E L++ L ++F
Sbjct: 2899 RVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEF 2958
Query: 2025 EDLFKQ-EESLKNIKDSLQQSSGRIDIIHSKKT---------------AALQSATP-VER 2067
Q E++L+ L+ + ++ ++ K T ALQ A P E
Sbjct: 2959 SGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTED 3018
Query: 2068 VKLQ-----EALSQLDFQWEKVNKMYKD--------RQGRFDRSVEKWRRFHYDIKIFNQ 2114
+K Q L KV+ + K+ +G ++ +RF + F Q
Sbjct: 3019 LKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQ 3078
Query: 2115 WLTEAEQFLRKT-QIPENWEHAKYKWYLKELQDGIGQRQTVVRTLN---ATGEEIIQQSS 2170
WL A+ K IP+N L+++Q+ + + + LN + GE + +
Sbjct: 3079 WLVNAKITTAKCFDIPQNISEVSTS--LQKIQEFLSESENGQHKLNMMLSKGELLSTLLT 3136
Query: 2171 KTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWL------- 2223
K A +Q K+ + W+ L ++ LE K + +F+ WL
Sbjct: 3137 KEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMV 3196
Query: 2224 -EEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPE 2282
E ++ + +P + ++Q+L+ LE++ +L + +QL E
Sbjct: 3197 HESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWE-----------GQA 3245
Query: 2283 EQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSP 2342
+++ Q + Q++ +S EK ++ + + Q +++L++ W++
Sbjct: 3246 ASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQD-------WMTD 3298
Query: 2343 IRNQLEIYNQP-NQEGPFDVQETEIAV-----QAKQPDVEEILSKGQH-LYKEKPATQPV 2395
+ L+ Y P + + D + ++ Q K+ ++ I+++G+ L P P
Sbjct: 3299 AIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT 3358
Query: 2396 ----------------------KRKLEDLSSEW--------------KAVNRLLQELRAK 2419
K +LE S+W ++ L E +
Sbjct: 3359 IQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQ 3418
Query: 2420 QPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLM-------LEVPALADFN 2472
+L T +G + L+ + V++ + + +E+ + M LE+ L +
Sbjct: 3419 HAELRDKTTMLGKA-----KLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERY 3473
Query: 2473 RAWTELTD-------------------------WLSLLDQVIKSQRVMVGDLEDINEMII 2507
RA E WL + + V+ GD
Sbjct: 3474 RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH------- 3526
Query: 2508 KQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTI------ITDR-IERIQNQWDEV 2560
+ T++DL++ + E Q L N + I DR +E ++ W
Sbjct: 3527 THETTLRDLQELQVHCAE----GQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAY 3582
Query: 2561 QEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETK 2620
Q L R Q N ++ + ++ ++ L A K+ + ++ + K
Sbjct: 3583 QHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMK 3642
Query: 2621 QLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAAL 2680
+ +++ ++ V+ A ++L D S ++R T+ + + ++++ +V E+ L
Sbjct: 3643 KWHEEVTAYRDEVEEVGARAQEIL-DESHVNSRMGCQATQ-LTSRYQALLLQVLEQIKFL 3700
Query: 2681 EETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGE 2740
EE + L++ L + W T N AT+ +++ D+ + + +K + L +
Sbjct: 3701 EEEIQSLEESESSLSSYSDWY--GSTHKNFKNVATKIDKV--DTVMMGKKLKTLEVLLKD 3756
Query: 2741 IEAHTDVYHNLDENSQKILRSLEGSDDAVL---LQRRLDNMNFKWSELRKKSLNIRSHLE 2797
+E + + E ++ ++ LE + L + ++ + S +RK+ + + L
Sbjct: 3757 MEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLH 3816
Query: 2798 AS---SDQWKRLHLSLQELLVWLQLKDD---ELSRQAPIGGDFPAVQKQNDVHRAFKREL 2851
+ SD+ K L + E L + ++ EL + + ++Q+ H + +
Sbjct: 3817 LAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSV 3876
Query: 2852 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 2911
+ K ++ ++ V + + ++ L+ YQ+ + E ++ K E+ N+E
Sbjct: 3877 REKGEALLELVQDVTL---KDKIDQLQSDYQDLCSIGKEHVFSLEAKV--KDHEDYNSEL 3931
Query: 2912 EKLNLHSADWQ-RKIDETLERLQELQEATDELDLKLRQAEVIKG------SWQPVGDLLI 2964
+++ R + L L+ T +L E I G + Q GD LI
Sbjct: 3932 QEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLI 3991
Query: 2965 DSLQDHLEKVKALRGEIAPLKENV-SHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL 3023
DHL+ A LK+NV +H+ + + S +L
Sbjct: 3992 GQCADHLQ---------AKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQK----- 4037
Query: 3024 QVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPK 3083
V+ +D ++Q + + A Q L S Q P RA + +V ++ + Q +
Sbjct: 4038 HVSRQDTLQQC----QAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTY---- 4089
Query: 3084 MTELYQSLADLNNVRFSAYRTAMKLRRLQKAL 3115
+L S+ DL+N S TA +++ ++ +
Sbjct: 4090 -LDLLCSMCDLSNA--SVKTTAKDIQQTEQTI 4118
Score = 172 bits (435), Expect = 7e-42
Identities = 589/3144 (18%), Positives = 1177/3144 (37%), Gaps = 541/3144 (17%)
Query: 272 QQITVSLAQGYERTSSPKP----RFKSYAYTQAAYVTTSDPTRSPF----PSQHL-EAPE 322
+Q S+ Q E P+P +F + Q+ D TR+ S+ L E E
Sbjct: 2746 EQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTE 2805
Query: 323 DKSFGSSLMES-EVNLDRYQTALEEVLSWLLSAEDT----LQAQGEISNDVEVVKDQFHT 377
D+SF + E + + T +E + + L A E ++ + K++ H
Sbjct: 2806 DESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHR 2865
Query: 378 HEGYMMDLTAHQGRVGNILQL-GSKLIGTGKLSEDEETEVQEQMN-------LLNSRWEC 429
D +A Q ++ I +L S+ IG +LS E + + N L+++ +
Sbjct: 2866 WSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQA 2925
Query: 430 LRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQH 489
LR + + ++ + L+N + + E+ + L++ ++Q
Sbjct: 2926 LRADWKQWEDSVFQTQSCLENLVSQ-------------MALSEQEFSGQVAQLEQALEQF 2972
Query: 490 KVLQEDLEQEQVRVNSL-THMVVVVDESSGDHATAAL---EEQLKVLGDRWANICRWTED 545
L + Q+ + T +V G AL E + + L + +CR++ D
Sbjct: 2973 SALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRD 3032
Query: 546 RWVLLQDILLKWQRLTEE-QCLF---SAWLSEKEDAVNKIHTTGFKD------------- 588
L K L +E CL S KE + + F+D
Sbjct: 3033 ----LSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTA 3088
Query: 589 ------QN--EMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL----KNKSVTQKT 636
QN E+ +SLQK+ ++ E + + + S K +LLSTL K K + K
Sbjct: 3089 KCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLS-KGELLSTLLTKEKAKGIQAKV 3147
Query: 637 EAWLDNFARCWDNLVQK---LEKSTAQISQAVTTTQP-----SLTQTTVMETVTTV---- 684
A +++ NL QK LE Q+ + +P S T+ V E+ +
Sbjct: 3148 TAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLP 3207
Query: 685 -TTREQILVKHAQEELPPPPPQKKR---------------------------QITVDSEI 716
REQ ++ EE+ PQ R Q S +
Sbjct: 3208 AKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNL 3267
Query: 717 RK----RLD----------VDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKE-KVNA 761
K RLD + I EL W+T + +L S + + + D + K+ A
Sbjct: 3268 TKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDS--YCHPTSDKSVLDSRTLKLEA 3325
Query: 762 IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFC--------Q 813
+ K EK +++ +++++ EG+ +I+Q + + W Q
Sbjct: 3326 LLSVKQEKEIQMKMIVTRGESVLQNTSPEGI--PTIQQQLQSVKDMWASLLSAGIRCKSQ 3383
Query: 814 LLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEV 873
L W YQ+ + F + +E +E Q + T + + K+ +EV
Sbjct: 3384 LEGALSKWTSYQDGVRQFSGWMDSMEANLNESER----QHAELRDKTTMLGKAKLLNEEV 3439
Query: 874 NRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFD 933
S L +E ++++ + E + L ++ + +Q R KE T +
Sbjct: 3440 LSYSSL---LETIEVKGAGMTEHYVTQLELQ--------DLQERYRAIQERAKEAVTKSE 3488
Query: 934 TLPPMR--YQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSG 991
L + YQ + A W+ Q + KL + D E L +LQ LQ E Q+
Sbjct: 3489 KLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQA- 3547
Query: 992 LYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQN 1051
L++ + PS I + E + W+ +L E + +NKLR ++
Sbjct: 3548 --LLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQ 3605
Query: 1052 HIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 1111
Q + +W+ + + + + QL Q + ++ + + V Q+I
Sbjct: 3606 KFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEI 3665
Query: 1112 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1171
+E+ SR+ + +L +++ + QV + + L+ ++ + LS +W
Sbjct: 3666 LDESHVN--SRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGS 3723
Query: 1172 AEEEY------------LERDFEYKTPDELQKAVEE----MKRAKEEAQQ-----KEAKV 1210
+ + + + KT + L K +E+ +K A+E+ ++ +E +
Sbjct: 3724 THKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEA 3783
Query: 1211 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1270
+ L + ++ + Q + ++KE TL L + KCK L + A + E+L
Sbjct: 3784 ERLRKEIHDHMEQLKELTS-TVRKEHMTLEKGLH-LAKEFSDKCKALTQWIAEYQEILHV 3841
Query: 1271 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1330
E+ L E + +L + SL+ + E + +R + L +
Sbjct: 3842 PEEPKMELYEKKAQLSKYK--------------SLQQTVLSHEPSVKSVREKGEALLEL- 3886
Query: 1331 VMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQE---------- 1380
V D + ++++ S +++L LE ++ ++ L +++
Sbjct: 3887 VQDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLV 3946
Query: 1381 --------SLTFIDKQLAAYIA---------DKVDAAQMP------QEAQKIQSDLTSHE 1417
SL I +QLA + A D+++ QM Q A +Q+ L
Sbjct: 3947 APDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLK--- 4003
Query: 1418 ISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEV 1477
+ + H QG + + + AQ+ Q + + QK + + LQ+ + L V
Sbjct: 4004 ---QNVHAHLQGTKDSYSAICS--TAQRMYQSLEHEL---QKHVSRQDTLQQCQAWLSAV 4055
Query: 1478 KMHL------PALETKSVEQ----EVVQSQLNHCVNLYKSLSE-----VKSEVEMVIKTG 1522
+ L P ++++Q +Q Q ++L S+ + VK+ + + +T
Sbjct: 4056 QPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE 4115
Query: 1523 RQIVQKK-QTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTE 1581
+ I QK Q +N + E + LK +EL + + QQL+ + R E+N+
Sbjct: 4116 QTIEQKLVQAQNLTQGWEEIKHLK---SELWIYLQDADQQLQNMKR--RHSELELNIAQN 4170
Query: 1582 WLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKK 1641
+ S V+ L S+ A S+ + E + + K+
Sbjct: 4171 MV----------SQVKDFVKKLQSKQA-----------------SVNTIIEKVNKLTKKE 4203
Query: 1642 ETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD-------HITKWIIQA 1694
E+ +++ LN W+ + ++ NL L+ ++ ++ D + K+ +
Sbjct: 4204 ESPEHKEINHLNDQWLDLCRQSN---NLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEW 4260
Query: 1695 DTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQIS 1754
D L S+ + + LK+L L + + ++ +DQ ++ + ++LV+ Q S
Sbjct: 4261 DNLA-RSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTS 4319
Query: 1755 ELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEE-------D 1807
L R+ + IK K + + LE+ N + E +E +Q N+ E D
Sbjct: 4320 HLEQRWFQLEDLIKR-KIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPD 4378
Query: 1808 FNKDMNEDNEGTVKELLQRGDNLQQRITDE---------RKREEIKIKQQLLQTKHNALK 1858
+++ D+ EL + L+ I D +R+ I+ Q+ N L
Sbjct: 4379 MAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLS 4438
Query: 1859 DLRSQRRK---KALEISHQWYQYKRQADDLLKCLDD---IEKKLASLPEPRDERKIKEID 1912
DL QRRK KAL Q+ QA ++ + + + LP+ + +
Sbjct: 4439 DLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD-----VSKQV 4493
Query: 1913 RELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHT 1972
+ + + L + + GL G + E T+ + S+ +++ + + + H
Sbjct: 4494 KTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHR 4553
Query: 1973 VREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL-CAKDFEDLFKQE 2031
++E LE + V + E + L+ ++ P++ + +L Q
Sbjct: 4554 LQE-----------LEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQL 4602
Query: 2032 ESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDR 2091
+NI + + + + L S V+ L E L+ L Q+ + + KD+
Sbjct: 4603 AKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDK 4662
Query: 2092 QGRFDRSVEKWRRFHYDIKIFNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQ 2150
+ ++ + + I++ Q L+E E QFLR +++P + + LQDG
Sbjct: 4663 FYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEE----ALSLQDGCRA 4718
Query: 2151 RQTVVRTLNATGEEIIQQSS---KTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKN 2207
V L +E+ Q+ T +K+ L + + +Q R LE+ +
Sbjct: 4719 ILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTS 4778
Query: 2208 ILSEFQRDLNEFVLWLEEAD------NIASIPLEP---------GKEQQLKEKLEQVKLL 2252
E ++ + L+ N ++P E G Q L++V +
Sbjct: 4779 AYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIH 4838
Query: 2253 VEEL-----PLR-QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALP 2306
+E+L PL + Q+ G + + E + E+++ Q+ ++SR+L
Sbjct: 4839 LEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLD 4898
Query: 2307 EKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQ----------- 2355
+ ++A++ L+ L+D++E++ + + +++ L I N +
Sbjct: 4899 WLR-RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKE 4957
Query: 2356 --------------EGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE------------- 2388
E D+QE A++ +Q + EI S+ Q Y+
Sbjct: 4958 LISADLEHSLAELSELDGDIQE---ALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQE 5014
Query: 2389 -----------KPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQT 2437
+ A + +K +E S+E + L+EL + L P + G +
Sbjct: 5015 LLQLAGNGLDVESAEENLKSHMEFFSTE-DQFHSNLEELHSLVATLDPLIKPTGKEDLE- 5072
Query: 2438 VTLVTQPVVTKETAISKLEMPSSLMLEVPALA-----DFNRAWTELTDWLSLLDQVIKSQ 2492
Q V + E ++ S +++ D+ +A E+ + ++ ++ +
Sbjct: 5073 -----QKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEF 5127
Query: 2493 RVM-VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2551
++ + E + + KA + + ++ L A L+ KT N ++ ++ +
Sbjct: 5128 SLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLE-KTGNDASKATLSRSMT 5186
Query: 2552 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2611
+ +W ++ Q++ + L + + + T + ++A +++ Q + KL +
Sbjct: 5187 TVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAE 5246
Query: 2612 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA----DDTRKVHMIT-------- 2659
+ + +L Q Q+ + + L +L+D +A ++ + IT
Sbjct: 5247 LLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLN 5306
Query: 2660 --ENINASWRSIHKRVSEREAA----------LEETHRLLQ----QFPLDLEKFLAWLTE 2703
E + + + + + + +RE ++ET L + LE+ LTE
Sbjct: 5307 MQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE 5366
Query: 2704 AETTANVLQDATRKER-----------------LLEDSKGVKELMKQWQDLQGEIEAHTD 2746
A ++ +++ L E + +K + Q QD E+E
Sbjct: 5367 ATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLK-IRDQIQDKIKEVEQSKA 5425
Query: 2747 VYHNLDENSQKILRSL---------------EGSDDAVLLQRRLDNMNFKWSELRKKSLN 2791
L QK+ + L + D +L LD N K EL
Sbjct: 5426 TSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMEL---DAA 5482
Query: 2792 IRSHLEASSDQWKRLHLSLQELL-VWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 2850
++ LE + K L + +L + Q +R + + +++ N++ +
Sbjct: 5483 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5542
Query: 2851 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2910
++ + + T+ + + L +E +E+ E A +T L+ T
Sbjct: 5543 IEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEA--MTEKLQYLTSVYCT- 5599
Query: 2911 WEKLNLHSADWQRKIDETLE----RLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS 2966
EK++ A+ R+ +E + RLQ LQ+A D+K +AE+ K
Sbjct: 5600 -EKMSQQVAELGRETEELRQMIKIRLQNLQDAAK--DMKKFEAELKK------------- 5643
Query: 2967 LQDHLEKVKALR-----GEIAPLKENVSHVNDLARQLTTL-----GIQLSPYNLSTLEDL 3016
LQ LE+ +A G ++ LKE +SH L ++ +L +QL L ED+
Sbjct: 5644 LQAALEQAQATLTSPEVGRLS-LKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDV 5702
Query: 3017 NTRWKLLQVAV---EDRVRQLHEA 3037
L A+ E+ R H A
Sbjct: 5703 VASLPLCHAALRLQEEASRLQHTA 5726
Score = 167 bits (423), Expect = 2e-40
Identities = 526/3006 (17%), Positives = 1150/3006 (38%), Gaps = 446/3006 (14%)
Query: 346 EVLSWLLSAEDTLQAQGEISNDVE--VVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLI 403
E+ +L A+ LQ +++E + ++ + ++ L + Q V I++
Sbjct: 4141 ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK----- 4195
Query: 404 GTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKT 463
KL++ EE+ +++N LN +W + +QSN + + Q+ ++ +D +
Sbjct: 4196 -VNKLTKKEESPEHKEINHLNDQW-----LDLCRQSNNLCLQREEDLQRTRDYHDCMNVV 4249
Query: 464 E----------ERTRKMEEEPLGPDLEDLKR---QVQQHKVLQEDLE---QEQVRVNSLT 507
E + + + E LE LK+ +Q+ K EDL+ Q+ + +L
Sbjct: 4250 EVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLD 4309
Query: 508 HMVVVVDESSG-DHATAALE--------------EQLKVLGDRWANICRWTEDRWV---- 548
+V +++S + LE E+L V+ R+ + W E++
Sbjct: 4310 DKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAE 4369
Query: 549 -------------LLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 595
LL D L L +Q L + + + + + + + + LS
Sbjct: 4370 ALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSD 4429
Query: 596 LQKLAVLKADLE-KKKQSMGKLYSLK-QDLLSTLKNKSVTQKTEAWL---DNFARCWDNL 650
Q +DL ++++ + K S K Q L++ + S Q+ E + ++ D+
Sbjct: 4430 AQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD- 4488
Query: 651 VQKLEKSTAQISQAVTTTQPSLTQTTVM--ETVTTVTTREQILVKHAQEELPP------- 701
V K K+ ++ T Q +T E + VT +E+ V +EL
Sbjct: 4489 VSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQ 4548
Query: 702 PPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNA 761
+ +++ + RK D + W+ +++ ++ PE + + K
Sbjct: 4549 KCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD-IVTFPEINLMNESSELHTQLAKYQN 4607
Query: 762 IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNW 821
I + E L R+ Q ++ + N SE+LN+ +F +++ +
Sbjct: 4608 ILEQSPEYENLLLTLQRTGQTILPSL-----NEVDHSYLSEKLNALPRQFNVIVALAKDK 4662
Query: 822 LEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE-PT--AIKSQLKI---CKDEVNR 875
I + L ++TT + + L+ Q S+ PT A++ L + C+ ++
Sbjct: 4663 FYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDE 4722
Query: 876 LSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTL 935
++GL ++ L + + GQ P D T + + + E+ + + DT
Sbjct: 4723 VAGLGEAVDELNQKKEGFRSTGQ-PWQPDKMLHLVTLYHRLK----RQTEQRVSLLEDTT 4777
Query: 936 PPMRYQETMSAIRTWVQQSETKLSI---PQLSVTDYEI-MEQRLGELQALQSSLQEQQSG 991
+ E M QQ E +L Q V + + E++L +L SLQ+
Sbjct: 4778 SAYQEHEKMC------QQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIV 4831
Query: 992 LYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQN 1051
L ++ +++++ K + + + +G K L+S + E + E +M + Q
Sbjct: 4832 LKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQT 4891
Query: 1052 HIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 1111
+ W+ V L + + +++++++ ++ ++Q+ +N+++ ++
Sbjct: 4892 EMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEK 4951
Query: 1112 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1171
+A+ ++ LE L EL+ + + + R+ L + + ++W+
Sbjct: 4952 FTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED 5011
Query: 1172 AEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1229
A+E + + ++ +E K+ E +++ ++ L +++ +I P +
Sbjct: 5012 AQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIK---PTGK 5068
Query: 1230 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE-----FK 1284
E L++++ +L Q + + L+ A WH+ E+ + +N+ E F
Sbjct: 5069 EDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFS 5128
Query: 1285 LKTTENIPGGAEEISE------VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINE 1338
L T + E++SE V++S + E+ +Q+ T ++
Sbjct: 5129 LLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLE-----KTGNDASKATLSR 5183
Query: 1339 ELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVD 1398
+ T RW L A ++K+LE ++ + E + + +L A+K
Sbjct: 5184 SMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKAS 5243
Query: 1399 AAQMP-------------QEAQKIQSDLTSHEIS-LEEMKKHNQGKEAAQRVLSQIDVAQ 1444
A++ ++ Q L +S L++ G+E ++ +I Q
Sbjct: 5244 KAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPP--LMQEITAMQ 5301
Query: 1445 KKLQDVSMKFRLFQKPANFEQRLQESKMI----------LDEVKMHL--PALETKSVEQE 1492
+ ++ K + K +Q L++ +M+ + E K +L P +E
Sbjct: 5302 DRCLNMQEKVKTNGKLV--KQELKDREMVETQINSVKCWVQETKEYLGNPTIE------- 5352
Query: 1493 VVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHY---N 1549
+ +QL L + + +E + + ++ T P EL ++ + L +
Sbjct: 5353 -IDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRD 5411
Query: 1550 ELGAKVTERKQQLEKCLKLSRKMRKEMN----VLTEWLAATDMELTKRSAVEGMPSNLDS 1605
++ K+ E +Q +LSR+++K +LT+ A TD + ++ + + LD
Sbjct: 5412 QIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDG 5471
Query: 1606 EVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1665
K +E K + + G+ LGK KL+ L+ I +AE
Sbjct: 5472 ------CNSKLMELDAAVQKFLEQNGQ-----LGKPLAKKIGKLTELHQQTIR---QAEN 5517
Query: 1666 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE--KKKPQQKEDVL--KRLKAELN 1721
L+ L + H+E +++ ++ I KWI +A L + Q +E + + L E
Sbjct: 5518 RLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESK 5577
Query: 1722 DIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKEL 1779
+I ++++ ++ L + +C + + Q++EL + IK ++ K++
Sbjct: 5578 EIDSELEAMTEKLQYLTSV---YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDM 5634
Query: 1780 EQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERK 1839
++F ++++KL LE Q L + + ++ + LL ++L+ ++
Sbjct: 5635 KKFEAELKKLQAALE---QAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV----- 5686
Query: 1840 REEIKIKQQLLQTKHNALKDL-----RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1894
+ +++ Q L+ + + L + +++A + H Q + + E+
Sbjct: 5687 -QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQ 5745
Query: 1895 KLASLPEPRDERKIKEIDRELQKKKEELNAVRR-QAEGLSEDGAAMAVEPTQIQLSKRWR 1953
++ L ++ I+ RE++ K + ++ QA+ + A ++ Q Q++
Sbjct: 5746 EMKHL-----QQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASL-- 5798
Query: 1954 EIESKFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEI--------THVS 2004
+ K + + + TV E E + TED+ E+ PS + + + T +S
Sbjct: 5799 NSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLS 5858
Query: 2005 QALLE-----VEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDI----IHSKK 2055
E +++P C ++I S+ R+ IH
Sbjct: 5859 PVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPST 5918
Query: 2056 TAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQW 2115
+A+ + P L L WE + + ++Q ++E+ +++ ++ +
Sbjct: 5919 SASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTK 5978
Query: 2116 LTEAEQFLRKTQIP------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2169
+ E L ++ P + EH + LQD I + Q ++ EE++ +S
Sbjct: 5979 MEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQ------SSLAEELVSES 6032
Query: 2170 SKTDAS---ILQEKLGSLNLRWQEVCKQLSDRKKRLEE----------QKNILSEFQRDL 2216
+ D + LQ L L R + + S +++ LEE Q+ L ++ +
Sbjct: 6033 CEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEA 6092
Query: 2217 NEFVLWLEEADNIASIPLEPGKE-QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV 2275
+E WL L P KE ++ +L + ++ E+ + L +L+ +L+
Sbjct: 6093 DELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLL 6152
Query: 2276 SAPI-SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLN 2334
+ +E ++L KL++ +++ RAL +KQ ++ ++ + E ++ Q
Sbjct: 6153 EGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE--KEESDVDLTATQSP 6210
Query: 2335 HLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLY-------- 2386
+ WL+ R + Q Q +E E + ++ + + S+G+ +
Sbjct: 6211 GVQEWLAQART---TWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAET 6267
Query: 2387 ----KEKP---------------ATQPVKRKLEDLSSEWKAVNRLLQELRAKQPD----- 2422
EKP A ++ K E L E+ +LLQ + ++ +
Sbjct: 6268 SGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYS 6327
Query: 2423 ----LAPGLTTI-GASPTQTVTLVTQPVVTKETAISKLEMPS------SLMLEVPALADF 2471
L G+ G PTQ + VT + A ++ S S+ LE
Sbjct: 6328 RPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGV 6387
Query: 2472 NRAWTELTDWLSLL-----------DQVIKSQRVMVGDLEDINEMIIKQKATMQD----- 2515
+ T L D L + + +Q ++ D+++++E + K K
Sbjct: 6388 SATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPEN 6447
Query: 2516 ------------------------LEQRRPQLEELITAAQNLKNK-----TSNQEARTII 2546
+ QR Q++E + N +N TS + + II
Sbjct: 6448 GDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYII 6507
Query: 2547 ------------TDRIERIQNQWDEVQE-------------HLQNRRQQLNEMLK----- 2576
++IE IQ D ++E LQ + + E+ K
Sbjct: 6508 LQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMY 6567
Query: 2577 ------------DSTQWLEAKEEAEQVLGQARAKLESWKE---GPYTVDAIQKKITETKQ 2621
Q L K + E+ L LE+ +E G + K+ E +Q
Sbjct: 6568 DELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE--EIQQ 6625
Query: 2622 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2681
L +++ ++ L L R + +K + A ++ KR +R LE
Sbjct: 6626 LLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELE 6685
Query: 2682 ---ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQ 2738
ET L + +L + L + + + ++++ ++RL+ + + +Q L+
Sbjct: 6686 YILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE--NEDRLI-------DRITLYQHLK 6736
Query: 2739 GEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEA 2798
+ + + + ++ +++L S+ SD L+ +L+ + W K LE
Sbjct: 6737 SSLNEYQPKLYQVLDDGKRLLISISCSD----LESQLNQLGECWLSNTNKMSKELHRLET 6792
Query: 2799 SSDQWKRLHLSLQELLVWLQLKDDEL----SRQAPIGGDFPAVQKQNDVHRAFKRELKTK 2854
W R +L+ WLQ D L + + + V+ + F +E+ +
Sbjct: 6793 ILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQ 6852
Query: 2855 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 2914
+ S L T L + ++ T LR + ++++W L
Sbjct: 6853 SSLKSSVLSTGNQLLRLKKVD---------------------TATLRSELSRIDSQWTDL 6891
Query: 2915 NLHSADWQRKIDE-TLERLQELQEATDELD-LKLRQAEVIKGSWQPVGDLLIDSLQDHLE 2972
+ Q K+ + +++L ++ + + L + + K + ++ ++L+
Sbjct: 6892 LTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQ 6951
Query: 2973 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED----LNTRWKLLQVAVE 3028
K K + +I + V VN Q+++ ++ + + + +N W++LQ V
Sbjct: 6952 KYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVT 7011
Query: 3029 DRVRQL 3034
++++ L
Sbjct: 7012 EKIQLL 7017
Score = 159 bits (401), Expect = 6e-38
Identities = 495/2699 (18%), Positives = 1027/2699 (38%), Gaps = 459/2699 (17%)
Query: 413 ETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE 472
E ++ L WE L+ EKQ L+ L + Q + L TK E K+ E
Sbjct: 5930 EPSATAKLGDLQRSWETLKNVISEKQRTLYEAL-ERQQKYQDSLQSISTKMEAIELKLSE 5988
Query: 473 EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV---VVVDESSGDHATA-ALEEQ 528
P + Q+ +H+ L +++ Q +N L + +V + D A AL+
Sbjct: 5989 SP--EPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQST 6046
Query: 529 LKVLGDRWANICRWTEDRWVLLQDIL---LKWQRLTEEQCL---------FSAWLSEKED 576
L VL +R + I + LL++ L L+ QR +EQ L +WL +
Sbjct: 6047 LTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQR--QEQALQRYRCEADELDSWLLSTKA 6104
Query: 577 AVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKT 636
++ + K+ +M + L + ++E+K ++ +L ++LL L+ K+ T+
Sbjct: 6105 TLDTALSPP-KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL--LEGKAHTKDE 6161
Query: 637 EAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMET----VTTVTTREQILV 692
L R +L+ S ++ +A+ Q ++ Q T E V T+ +
Sbjct: 6162 AEQLAGKLR-------RLKGSLLELQRALHDKQLNM-QGTAQEKEESDVDLTATQSPGVQ 6213
Query: 693 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 752
+ + Q++ + E+ + L + L S +R E +L
Sbjct: 6214 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL-------------- 6259
Query: 753 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFC 812
I+ AE DA L +++ EG + A +Q+ +W
Sbjct: 6260 ---------IQHSAAETSG---DAGEKPDVLSQELGMEGEKSS----AEDQMRMKWESLH 6303
Query: 813 QLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK--IQPTTPSEPTAIKSQLKICK 870
Q S + L+ N++ Q+ EQ+ + N L + PT KS +
Sbjct: 6304 QEFSTKQKLLQ---NVLE-----QEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV---- 6351
Query: 871 DEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQT 930
+ L GL E + QS K + + H +Q D
Sbjct: 6352 --TSLLDGLNQAFEEVSSQSGGAKRQ--------------SIHLEQKLYD---------- 6385
Query: 931 IFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS 990
+SA TW+ E +L + + E E L + L ++E
Sbjct: 6386 ------------GVSATSTWLDDVEERLFVATALLP--EETETCLFNQEILAKDIKEMSE 6431
Query: 991 GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIE-------GRWKKLSSQLVEHCQKLEEQM 1043
+ + +K S+ + + IE GR L S + + C +++E++
Sbjct: 6432 EM--------DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERL 6483
Query: 1044 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNS 1103
++ QN ++ L +A+ + ++ + + + +Q++ + ++ +
Sbjct: 6484 QQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPV-AEQIEAIQQAEDGLKEFDAGIIE 6542
Query: 1104 VNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLS 1163
+ G K++ E +P EL +L +D + + +R+ L L ++ L
Sbjct: 6543 LKRRGDKLQVE-QPSM-----QELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 6596
Query: 1164 EMHEWMTQAEEEYL-ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1222
++ + + +E+ ++ + +E+Q+ ++ + KE Q E+ + +LTE++ I
Sbjct: 6597 DLADLLETGQEKMAGDQKIIVSSKEEIQQLLD---KHKEYFQGLESHM-ILTETLFRKII 6652
Query: 1223 QAPPVAQEALKKELE---TLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN 1279
A++KE + L + R + + LE + W L ++ ++ L
Sbjct: 6653 SF------AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLE 6706
Query: 1280 EVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIR-ILAQTLTDG--------- 1329
VE + + G EE + L L +H + + N+ + L Q L DG
Sbjct: 6707 VVESSIPSV----GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISC 6762
Query: 1330 GVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ---ESLTFID 1386
++ +N+ E + S ++ +E R + +L+ + E+ +H +Q + L F
Sbjct: 6763 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 6822
Query: 1387 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKK 1446
+Q + +PQE + ++ L + +E+ + K + +Q+ + KK
Sbjct: 6823 QQ----------SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQL-LRLKK 6871
Query: 1447 LQDVSMKFRLFQKPANFEQRLQESKMILDEV-KMHLPALETK----------SVEQEVVQ 1495
+ +++ L + + + L + +++ ++ + L ++ S+ + V+Q
Sbjct: 6872 VDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQ 6931
Query: 1496 SQLNHCVNL--YKSLSEVKSEV------------------EMVIKTGRQIVQKKQTENPK 1535
++ N YK++ E + + V++ Q V+ K+++
Sbjct: 6932 KDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK-T 6990
Query: 1536 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1595
+ E++ A+ + L VTE+ Q LE L+ + + L W + L ++
Sbjct: 6991 DFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHR 7050
Query: 1596 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE---TLVEDKLSLL 1652
+ G +++ + + + + I+ ++ ++ I + G AL + KKE ++V L L
Sbjct: 7051 I-GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLAL--IQNKKEDVSSIVMSTLREL 7107
Query: 1653 NSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDE-----SEKKKPQ 1707
W + + LL + D I ++++A L + Q
Sbjct: 7108 GQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQ 7167
Query: 1708 QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRF----AAI 1763
+ D L+ L+ +L + L+ + + + E+N R+ I
Sbjct: 7168 VQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEI 7227
Query: 1764 SHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNE------ 1817
+ ++++ KA + L +++ ++ ++ + + L + NKD+ +D
Sbjct: 7228 AEQLQSSKALLQL--WQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQD 7285
Query: 1818 --------GTVKELL----QRGDNLQQRI----TDERKREEIKIKQQLLQTKHNALKDLR 1861
GTVK+ L + G+ L+Q++ + +++ + Q L + K
Sbjct: 7286 CNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQT 7345
Query: 1862 S--------QRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDR 1913
S + K+LE W +A+++L+ D D I+E
Sbjct: 7346 SLQAGVLDYETFAKSLEALEAWIV---EAEEILQGQDPSHSS--------DLSTIQERME 7394
Query: 1914 ELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ----LSKRWREIESKFAQFRRLNFAQ 1969
EL+ + + +++ + L+E G + + +I+ L++ W I S+ + R + Q
Sbjct: 7395 ELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTE--RFSKLQ 7452
Query: 1970 IHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFK 2029
++ +T + E + EI+ Q LLE ++ A +L ++F
Sbjct: 7453 SFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQR---AHELFQ---AEMFS 7506
Query: 2030 QEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 2089
+++ L +I II ++ L+ +R + L+ L QW+ V + +
Sbjct: 7507 RQQILHSI------------IIDGQR--LLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQ 7552
Query: 2090 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF----LRKTQIPENWEHAKYKWYLKELQ 2145
R+G D + +W+R+ + +WL E L IP + + +
Sbjct: 7553 QRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 7612
Query: 2146 DGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQ 2205
+ Q+ + + T+ A G++++ + + LQ +L + +W+ RLEEQ
Sbjct: 7613 VFLRQQGSYILTVEA-GKQLLLSADSGAEAALQAELAEIQEKWKSA-------SMRLEEQ 7664
Query: 2206 KNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQ-VKLLVEELPLRQGILK 2264
K L+ +D W E+ + + LE K + K+KL Q + EEL Q K
Sbjct: 7665 KKKLAFLLKD------W-EKCEKGIADSLE--KLRTFKKKLSQSLPDHHEELHAEQMRCK 7715
Query: 2265 QLNETGG------------PVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEI 2312
+L G +SA IS ++ L +++ QW ++ L ++ +I
Sbjct: 7716 ELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQI 7775
Query: 2313 EAQIKDLGQLEKKLEDLEEQLNHLLLWLSP-----IRNQLEIYNQPNQEGPFDVQETEIA 2367
++ + +K ++L E L + +S I +E + QE QE +I
Sbjct: 7776 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQ 7835
Query: 2368 VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 2427
+Q + E L+K H E A++ ++ KL ++ W+ LL + A+ L
Sbjct: 7836 LQ----QMGERLAKASH---ESKASE-IEYKLGKVNDRWQ---HLLDLIAARVKKL---- 7880
Query: 2428 TTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQ 2487
KET + A+ ++ + L WL+ ++
Sbjct: 7881 --------------------KETLV--------------AVQQLDKNMSSLRTWLAHIES 7906
Query: 2488 VIKSQRVMVG-DLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLK---NKTSNQEAR 2543
+ V + E+I + +Q+ +D+E+ + ++ + L + +
Sbjct: 7907 ELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAEC 7966
Query: 2544 TIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVL--GQARAKLES 2601
I + +W + RR ++ E + ++L+ E L + A S
Sbjct: 7967 DSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPS 8026
Query: 2602 WKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITEN 2661
YTV ++++ + + + + + T +++ N +L R+ D + +
Sbjct: 8027 SSGVIYTV--AKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHE 8084
Query: 2662 INASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLL 2721
N W ++ KRV+ L+ ++F + L WLTE + ++ + +
Sbjct: 8085 GNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECD--- 8141
Query: 2722 EDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFK 2781
V+ +KQ + Q EI + + + ++++ E DA +++ LD
Sbjct: 8142 -----VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPL-DAAIIEEELD----- 8190
Query: 2782 WSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQN 2841
ELR+ + +E R H + L+ L L DDE
Sbjct: 8191 --ELRRYCQEVFGRVE-------RYH----KKLIRLPLPDDE------------------ 8219
Query: 2842 DVHRAFKRELKTKEPVIMSTL----ETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 2897
H REL+ ++ +S L + L+ QP L +P R++
Sbjct: 8220 --HDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL------RSERSG 8271
Query: 2898 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERL--QELQEATDELDLKLRQAEVIKG 2954
R + + EW+ H D R ++ + R E +E D+ D LR A + G
Sbjct: 8272 RDTPASVDSIPLEWD----HDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSG 8326
Score = 142 bits (359), Expect = 5e-33
Identities = 462/2419 (19%), Positives = 930/2419 (38%), Gaps = 354/2419 (14%)
Query: 255 KVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFP 314
+ TKE QLH + +++T + E + ++ + + S +
Sbjct: 3631 RATKE--IQLHQMKKWHEEVT-AYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQ 3687
Query: 315 SQHLEAPEDKSFGSSLMESEV-NLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVK- 372
+ L+ E F +E E+ +L+ +++L W S + + V+ V
Sbjct: 3688 ALLLQVLEQIKF----LEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMM 3743
Query: 373 -DQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEET--EVQEQMNLLNSRWEC 429
+ T E + D+ + + + G + + + E E E+ + M L
Sbjct: 3744 GKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTST 3803
Query: 430 LRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQH 489
+R M + LH L + K K L W+ + +E EE + +L + K Q+ ++
Sbjct: 3804 VRKEHMTLEKGLH--LAKEFSDKCKALTQWIAEYQEILHVPEEPKM--ELYEKKAQLSKY 3859
Query: 490 KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 549
K LQ+ + + V S+ + A LE L
Sbjct: 3860 KSLQQTVLSHEPSVKSVR-----------EKGEALLE----------------------L 3886
Query: 550 LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK- 608
+QD+ LK ++ + Q + S ++ V + KD + S LQ ++EK
Sbjct: 3887 VQDVTLK-DKIDQLQSDYQDLCSIGKEHVFSLEAK-VKDHEDYNSELQ-------EVEKW 3937
Query: 609 KKQSMGKLYSLKQDLLSTLKNKSVTQKT---EAWLDNFARCWDNLVQKLEKSTAQISQAV 665
Q G+L + DLL T +++TQ+ +A ++ A D L K I Q
Sbjct: 3938 LLQMSGRLVA--PDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCA 3995
Query: 666 TTTQPSLTQTT------VMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKR 719
Q L Q ++ + + + Q + + + EL RQ T+
Sbjct: 3996 DHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQK---HVSRQDTLQ------ 4046
Query: 720 LDVDITELHSWITRSEAVLQ-SPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASR 778
+ +W++ + L+ SP+ + R E AI++ K FR LQ+ +R
Sbjct: 4047 ------QCQAWLSAVQPDLEPSPQPPLSRAE-----------AIKQVK--HFRALQEQAR 4087
Query: 779 SAQALVEQMVNEG-----VNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYN 833
+ L+ M + A I+Q + + + ++ L W E ++ +
Sbjct: 4088 TYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQ---GWEEIKHLKSELWI 4144
Query: 834 QLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIAL 893
LQ +Q + + + E ++ + KD V +L Q + + + L
Sbjct: 4145 YLQDADQQLQNMK-----RRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKL 4199
Query: 894 KEKGQGPMFLDADFVAFTNHFKQVFSDV--QAREKELQTIFDTLPPMRYQETMSAIRTWV 951
+K + P + NH + D+ Q+ LQ D Y + M+ + ++
Sbjct: 4200 TKKEESPEHKEI------NHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFL 4253
Query: 952 QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 1011
++ T+ L+ +D E L L+ L +LQE++ + L ++M + +
Sbjct: 4254 EKFTTEWD--NLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDK 4311
Query: 1012 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1071
+ + +E RW +L + Q + +L +Q+ Q L +W E + E
Sbjct: 4312 ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEAL 4371
Query: 1072 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1131
++ + L + S+++ Q L S+ + ++ + ++ L +
Sbjct: 4372 KQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQ 4431
Query: 1132 TQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQK 1191
+ + + V R++ L L + + + + Q E + + R+ PD++ K
Sbjct: 4432 SHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSK 4491
Query: 1192 AVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKE-------LETLTTNYQ 1244
V+ K A +A +K V + AQ + +E ++E L+ L + Y
Sbjct: 4492 QVKTCKSA-------QASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYD 4544
Query: 1245 WLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDS 1304
+ + + + + LE+ +KA WL + + N+ + E+ L
Sbjct: 4545 SVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAK 4604
Query: 1305 LENLMRHSEDNPNQIRILAQT---------LTDGGVMDELINEELETFN-------SRWR 1348
+N++ S + N + L +T D + E +N FN ++
Sbjct: 4605 YQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFY 4664
Query: 1349 ELHEEAVRRQK---LLEQSIQSAQETEKSL---------HLIQESLTFIDKQLA-----A 1391
++ E + R++ L+E + QS E E ++E+L+ D A A
Sbjct: 4665 KVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVA 4724
Query: 1392 YIADKVDAAQMPQE-----AQKIQSDLTSHEISL-------------------EEMKKHN 1427
+ + VD +E Q Q D H ++L ++H
Sbjct: 4725 GLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHE 4784
Query: 1428 QGKEAAQRVLSQIDVAQKKLQDVSM----KFRLFQKPANFEQRLQESKMILDEVKMHL-- 1481
+ + +R L + Q K+ + ++ K +++ A LQ+S ++L V +HL
Sbjct: 4785 KMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAG---SLQDSGIVLKRVTIHLED 4841
Query: 1482 --PALETKSVE--QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK--KQTENPK 1535
P L+ + E + +QS L ++ E +E E ++VQ QTE +
Sbjct: 4842 LAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECE------SRMVQSIDFQTEMSR 4895
Query: 1536 ELD--ERVTA-------LKLHYNELG---AKVTERKQQLEKCLKLSRKM---RKEMNVLT 1580
LD RV A L L+ ++ K+ +++++ L++ + KE
Sbjct: 4896 SLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKA 4955
Query: 1581 EWLAATDME--LTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL 1638
+ L + D+E L + S ++G ++ + +AT EI Q + +V +A L
Sbjct: 4956 KELISADLEHSLAELSELDG---DIQEALRTRQATLTEIYSQ---CQRYYQVFQAANDWL 5009
Query: 1639 GKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL 1698
+ L++ L N + V S AEE L +E+ + F N++ + + D L+
Sbjct: 5010 EDAQELLQ-----LAGNGLDVES-AEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLI 5063
Query: 1699 DESEKKKPQQKEDVLKRLKA-ELNDIRPKVDSTR--DQAANLMANRGDHCRKLVEPQISE 1755
KP KED+ +++ + EL R DS D A D+ +K E I
Sbjct: 5064 ------KPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDY-QKAREEVIEL 5116
Query: 1756 LNHRFAAISH--RIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEE--DFNKD 1811
+N +S +KT + E E+ S+ + L+ + + ++ V L+E+ K
Sbjct: 5117 MNDTEKKLSEFSLLKTSSS----HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKT 5172
Query: 1812 MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEI 1871
N+ ++ T+ + + QR T R R + ++++L+ + + + KKA E+
Sbjct: 5173 GNDASKATLSRSM---TTVWQRWT--RLRAVAQDQEKILEDAVDEWTGF-NNKVKKATEM 5226
Query: 1872 SHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEG 1931
Q Q K K + +L +L E D + EL++++ L +R+Q
Sbjct: 5227 IDQ-LQDKLPGSSAEKA---SKAELLTLLEYHDTFVL-----ELEQQQSALGMLRQQTLS 5277
Query: 1932 LSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISY 1991
+ +DGAA PT + +EI + Q R LN + V+ +V E E+
Sbjct: 5278 MLQDGAA----PTPGEEPPLMQEITA--MQDRCLNMQE--KVKTNGKLVKQELKDREM-- 5327
Query: 1992 VPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDII 2051
T+I V + E ++ L P + + + ++ + L + +Q+ ++
Sbjct: 5328 ----VETQINSVKCWVQETKEYLGNPTI---EIDAQLEELQILLTEATNHRQNIEKMAEE 5380
Query: 2052 HSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI-K 2110
+K L + P E + LQ A LD K+ +D+ ++S + I K
Sbjct: 5381 QKEKYLGLYTILPSE-LSLQLAEVALDL---KIRDQIQDKIKEVEQSKATSQELSRQIQK 5436
Query: 2111 IFNQWLTEAEQFLRKTQIPENWEHAKY-KWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2169
+ T + KT +N AK + L E DG + + L+A ++ ++Q+
Sbjct: 5437 LAKDLTTILTKLKAKT---DNVVQAKTDQKVLGEELDGCNSK---LMELDAAVQKFLEQN 5490
Query: 2170 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNI 2229
+ L +K+G L Q+ +Q +R +L + + L E+ L + W+E+A +
Sbjct: 5491 GQL-GKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVL 5549
Query: 2230 ASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLEN 2289
A + QL+E+ + L+EE L+ + E + S +K+
Sbjct: 5550 AHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEK-----LQYLTSVYCTEKMSQ 5604
Query: 2290 KLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEI 2349
++ + + ++ + + + ++ KD+ + E +L+ L+ L
Sbjct: 5605 QVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALE--------------- 5649
Query: 2350 YNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAV 2409
Q T + + + ++E LS QHL E +E L + +AV
Sbjct: 5650 ----------QAQATLTSPEVGRLSLKEQLSHRQHLLSE----------MESLKPKVQAV 5689
Query: 2410 NRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA 2469
LR + D+ L A+ + L + + TAI + + + +++
Sbjct: 5690 QLCQSALRIPE-DVVASLPLCHAA----LRLQEEASRLQHTAIQQCNIMQAAVVQ---YE 5741
Query: 2470 DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITA 2529
+ + L + + I+ + V +++++ I + + Q ++ + Q+ L +
Sbjct: 5742 QYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5801
Query: 2530 AQNLKNKTSNQEARTIITD 2548
+ L K + +T+
Sbjct: 5802 CKMLTMKAKHATMLLTVTE 5820
Score = 119 bits (298), Expect = 6e-26
Identities = 407/2222 (18%), Positives = 875/2222 (39%), Gaps = 318/2222 (14%)
Query: 945 SAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSK 1004
S +++W+ + + S+ QL +E S EQ Y + EM
Sbjct: 521 SKLKSWIIKYGRRESVEQLLQNYVSFIEN---------SKFFEQYEVTYQILKQTAEMYV 571
Query: 1005 KAPSEI--SRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1062
KA + + E +W+ LS ++ LEE ++ + N + +L+ W+ +
Sbjct: 572 KADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLED 631
Query: 1063 VDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASR 1122
+ L + SE KK R L IQ ++N+ G + + +
Sbjct: 632 AEKMLNQ-------SENAKKDF--FRNLPHWIQ----QHTAMNDAGNFLIETCDEMVSRD 678
Query: 1123 LETELKELNTQWDHMCQQV--YARKEAL----KGGLEKTVSLQKDLSEMHEWMTQAEEEY 1176
L+ +L LN +W + +V YA+ + + K + V+L +E H+ ++ E
Sbjct: 679 LKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLS----EP 734
Query: 1177 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPP-------VAQ 1229
LE F ++ +++++ ++ +A+ K++T++ + + ++P
Sbjct: 735 LEVSFM-----NVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 789
Query: 1230 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE------- 1282
LK++L + Y L LEE+ L K N+ + +E
Sbjct: 790 SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSA 849
Query: 1283 -FKLK-------------TTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD 1328
FK K T I G++ + + + +L N+++H + Q +I +
Sbjct: 850 LFKQKHQELLACQENCKKTLTLIEKGSQSVQKFV-TLSNVLKHFDQTRLQRQIADIHVAF 908
Query: 1329 GGVMDELIN--EELETFNSRWRELHEEAVRRQKLL---EQSIQSAQETEKSLHLIQESLT 1383
++ + + + +ET + ++ E +K+L ++ ++ + E+ L E +
Sbjct: 909 QSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFS 968
Query: 1384 FIDKQ-LAAYI--ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQI 1440
+D++ L A++ D++ QE Q +Q + L + K QG+ + +I
Sbjct: 969 QLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRK----LHKQWKDLQGEAPYHLLHLKI 1024
Query: 1441 DVAQKKL--------QDVSMKFRLFQKPANFEQRLQESKMIL-DEVKMHLPALETKSVEQ 1491
DV + + ++ + +L + + E+ ++E ++ D+ HL + +E+
Sbjct: 1025 DVEKNRFLASVEECRTELDRETKLMPQEGS-EKIIKEHRVFFSDKGPHHLCEKRLQLIEE 1083
Query: 1492 EVVQSQLNHCVN-----LYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 1546
V+ + V + +L E+++ ++ + K E+P + + +
Sbjct: 1084 LCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYR--------KLMEDPDKWKDYTS---- 1131
Query: 1547 HYNELGAKVTERKQQLE--KCLKLSRKMRKEMNVLTEWLAATDMELTKRS-AVEGMPSNL 1603
++E + ++ + QL+ K + E+ E + +TKR + + S L
Sbjct: 1132 RFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNG---VTKRGETLSWLKSRL 1188
Query: 1604 DSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRA 1663
+V +++ E +KQ L ++ +AL T+L + E ++ + + I V +
Sbjct: 1189 --KVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEI-VKNSL 1245
Query: 1664 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDI 1723
EE ++ E Q+ E T+ + +A LL ++K KR+ A+ D+
Sbjct: 1246 EELISGSKEVQEQAEKILD-----TENLFEAQQLLLHHQQKT--------KRISAKKRDV 1292
Query: 1724 RPKVDSTRDQAANLMANRGDHCRKLVEP-----QISELNHRFAAIS----HRIKTGKASI 1774
+ ++ + L + RKL + E R ++ R +T K ++
Sbjct: 1293 QQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETV 1352
Query: 1775 PLKELEQFNSDIQKLL-----EPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1829
++ L Q S ++ L E L +E++Q + + + +N + G
Sbjct: 1353 -VRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQ 1411
Query: 1830 LQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCL 1889
+Q + + K IK+Q+ + + +D+++ K +W + + L +
Sbjct: 1412 NKQLLQQQAK----SIKEQVKKLEDTLEEDIKTMEMVKT-----KWDHFGSNFETLSVWI 1462
Query: 1890 DDIEKKLASLPEPRD--ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ 1947
+ EK+L +L + +I +I +Q+ + +L+++ GL E+ + A Q
Sbjct: 1463 TEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSI----VGLEEEAQSFA----QFV 1514
Query: 1948 LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL 2007
+ I++K Q RR +RE + E L + + + Q++
Sbjct: 1515 TTGESARIKAKLTQIRRYG----EELREHAQCL--EGTILGHLSQQQKFEENLRKIQQSV 1568
Query: 2008 LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-E 2066
E E L P + +K + ++ +L+ S I TA SA V
Sbjct: 1569 SEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAI-------TAFSASARKVVN 1621
Query: 2067 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT 2126
R + + L Q+E + + K+RQ + + W+R ++ F WL E
Sbjct: 1622 RDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSP 1681
Query: 2127 QIPENWEHAKYKWYL---KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGS 2183
++ + + K + L + LQ+ + + + L E + +SK D +++ L
Sbjct: 1682 EMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQ 1741
Query: 2184 LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLW----LEEADNIASIPLEPGKE 2239
L+ RW+++ + ++ R L+ +F L F +W L E + I + +
Sbjct: 1742 LDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV 1801
Query: 2240 --QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQ 2297
+ K+ +V+ EL QG L +L G E+ L+ K +
Sbjct: 1802 ALTRHKDHAAEVESKKGELQSLQGHLAKLGSLG---------RAEDLHLLQGKAEDCFQL 1852
Query: 2298 WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI-RNQLEIYNQPNQE 2356
+ + S+ + +Q + + + + Q L + QL + + + +N+ ++ +
Sbjct: 1853 FEEASQVVERRQLAL-SHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLN- 1910
Query: 2357 GPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQ--PVKRKLEDLSSEWKAVNRLLQ 2414
D + A+++ ++ ILSK Q+ K + Q + + L E + + LL
Sbjct: 1911 ---DALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLG 1967
Query: 2415 ELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRA 2474
+++ LA + + + + + T +L+ P+ L+ L FN+
Sbjct: 1968 TKQSEADALAVLKKAFQDQKEELLKSIED--IEERTDKERLKEPTRQALQ-QRLRVFNQL 2024
Query: 2475 WTELTD------WL-SLLDQVIKSQRVMVGDLE-DINEMIIKQKATMQDLEQRRPQ---L 2523
EL WL Q+ + +++ +IN + + T + + + + Q L
Sbjct: 2025 EDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGL 2084
Query: 2524 EELITAAQNLKNKTSN--QEARTIITDRI---------------ERIQNQWDEVQEHLQN 2566
+L+ QNLK+ S + A ++I R E +N+ + Q+ L N
Sbjct: 2085 IDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDN 2144
Query: 2567 ----RRQQLNEMLK-------------DST--QWLEAKEEAEQVLGQARAKLESWKEGPY 2607
+ L+E+ K +ST +WL+ E+ E+ + + R L W +
Sbjct: 2145 FTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLS 2204
Query: 2608 TVDAIQKKITE-TKQLAKDLRQWQTNVDVANDL-ALKLLRDYSADDTRKVHMITENINAS 2665
T D I+ Q+A+++ +N+D N L A +LL+++ ++ K + E
Sbjct: 2205 TRDEIEGWSNNCVPQMAENI----SNLD--NHLRAEELLKEFESEVKNKALRLEE----- 2253
Query: 2666 WRSIHKRVSEREAALE--ETHRLLQQFPLDLEKFLAWLTE-AETTANVLQD----ATRKE 2718
+H +V++ + + ET LQ DL + L E E L+D +T+ E
Sbjct: 2254 ---LHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVE 2310
Query: 2719 RLLED----------------SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSL 2762
+ + D E +K+ +D+Q E+++ + EN + R
Sbjct: 2311 KFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKY 2370
Query: 2763 EGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDD 2822
S + L R + + K + + ++ L+ S + K S+QE W
Sbjct: 2371 H-SAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE--KHFSESMQEFQEWF----- 2422
Query: 2823 ELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2882
+G A K++ + L+ K + + L++V L+ + Q
Sbjct: 2423 -------LGA--KAAAKESSDRTGDSKVLEAKLHDLQNILDSV-----SDGQSKLDAVTQ 2468
Query: 2883 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 2942
E + L Q V+ +++Q + N E++ ++ + + L ++ +L
Sbjct: 2469 EGQTLYAHLSKQIVSS-IQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2527
Query: 2943 DLKLRQAEVIKGSWQPVGDLL--IDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 3000
+L + + E + + + +G+ I ++ + KV+ GE+ +E++ ++ + L+
Sbjct: 2528 NLWIHEMEE-RFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2586
Query: 3001 LG 3002
G
Sbjct: 2587 EG 2588
Score = 114 bits (286), Expect = 1e-24
Identities = 345/2015 (17%), Positives = 772/2015 (38%), Gaps = 283/2015 (14%)
Query: 340 YQTALEEVLSWLLSAEDTLQAQGEI-SNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQL 398
Y + L+EV WLL L A + ++ +E + Q H+ M ++ + R+ N+
Sbjct: 3927 YNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMK 3986
Query: 399 GSKLIGT------GKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQK 452
G LIG KL ++ +Q + ++ A QS H + + Q
Sbjct: 3987 GDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSA---ICSTAQRMYQSLEHELQKHVSRQD 4043
Query: 453 -LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE------DLEQEQVRVNS 505
L++ WL+ + + PL + +QV+ + LQE DL +++
Sbjct: 4044 TLQQCQAWLSAVQPDLEPSPQPPLSR--AEAIKQVKHFRALQEQARTYLDLLCSMCDLSN 4101
Query: 506 LTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTE--- 562
+ D + Q + L W I + W+ LQD + Q +
Sbjct: 4102 ASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHS 4161
Query: 563 --EQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKK----------- 609
E + +S+ +D V K+ + N ++ + KL + E K
Sbjct: 4162 ELELNIAQNMVSQVKDFVKKLQSKQ-ASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLD 4220
Query: 610 --KQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTT 667
+QS ++DL T E +L+ F WDNL + +STA +A+
Sbjct: 4221 LCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKK 4280
Query: 668 TQPSLTQTTVMETVTTVTTREQILVKHAQ---EELPPPPPQ--KKRQITVDSEIRKRLDV 722
+L + + + ++Q +++H +EL ++R ++ I++++ V
Sbjct: 4281 LALALQERKY--AIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQV 4338
Query: 723 DIT-------------ELHSWITR-----SEAVLQSP-----EFAIFRKEGNFSDLKEKV 759
+T EL W +EA+ QSP + + S+L+ K
Sbjct: 4339 SVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQ 4398
Query: 760 NAIEREKAEKFRKLQDASRSAQALVEQMVNEGVN-----ADSIKQASEQLNSRWIEFCQL 814
++ + R + D + + ++++ +++ + +D + Q + LN +
Sbjct: 4399 MLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN-------KA 4451
Query: 815 LSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVN 874
LSE+ +L + +Q+QQ E+ E+ + P + Q+K CK
Sbjct: 4452 LSEKTQFLMA---VFQATSQIQQHERKIMFREHICLL-------PDDVSKQVKTCKSAQA 4501
Query: 875 RLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDT 934
L Q ++ L Q L ++ +Q S+V + +ELQ+++D+
Sbjct: 4502 SLKTYQNEVTGLWAQGRELMKEVT----------------EQEKSEVLGKLQELQSVYDS 4545
Query: 935 L----------------PPMRYQETMSAIRTWVQQSETKLSIPQLSV-TDYEIMEQRLGE 977
+ ++E W++Q++ ++ P++++ + + +L +
Sbjct: 4546 VLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADI-VTFPEINLMNESSELHTQLAK 4604
Query: 978 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSE-FEEIEGRWKKLSSQLVEHC 1036
Q + E ++ L L T + + +E+ Y SE + ++ + + +
Sbjct: 4605 YQNILEQSPEYENLLLTLQRTGQTILPSL-NEVDHSYLSEKLNALPRQFNVIVALAKDKF 4663
Query: 1037 QKLEEQMNKLRKIQNHIQTLKKWMAEVDV-FLK-EEWPA-LGDSEILKKQLKQCRLLVSD 1093
K++E + ++ + I+ + ++E++ FL+ + P L E L Q CR ++ +
Sbjct: 4664 YKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQ-DGCRAILDE 4722
Query: 1094 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLE 1153
+ + +++ +N+ + ++ +P Q D M V LK E
Sbjct: 4723 VAGLGEAVDELNQKKEGFRSTGQP--------------WQPDKMLHLV-TLYHRLKRQTE 4767
Query: 1154 KTVSLQKDLS---EMHEWMTQAEEEYLE--RDFEYKTPDELQKAVEEMKRAKEEA---QQ 1205
+ VSL +D + + HE M Q E L+ ++ + K +E A E++K A Q
Sbjct: 4768 QRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQD 4827
Query: 1206 KEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWH 1265
+K +T + + P+A E + ++++ + L + + E
Sbjct: 4828 SGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSI 4887
Query: 1266 ELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI---- 1321
+ + + ++ WL V+ +L + ++I E + + H E+ + +RI
Sbjct: 4888 DFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQE---EIRKIQIHQEEVQSSLRIMNAL 4944
Query: 1322 ------------------LAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQ 1363
L +L + +D I E L T + E++ + R ++ +
Sbjct: 4945 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQA 5004
Query: 1364 SIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEM 1423
+ ++ ++ L L L + + ++ + +L S +L+ +
Sbjct: 5005 ANDWLEDAQELLQLAGNGLDV--ESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPL 5062
Query: 1424 KKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPA 1483
K ++ Q+V S +Q+ +D + L Q+ Q+++ +EV +
Sbjct: 5063 IKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAR---EEVIELMND 5119
Query: 1484 LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE------- 1536
E K E ++++ +H + LSE K+ V +V +IV ++ + E
Sbjct: 5120 TEKKLSEFSLLKTSSSH--EAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDAS 5177
Query: 1537 ---LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1593
L +T + + L A ++++ LE + ++ TE + +L
Sbjct: 5178 KATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGS 5237
Query: 1594 SAVEGMPSNLDSEVAWGKATQKEIEKQKVHL-----KSITEVGEALKTVLGKKETLVEDK 1648
SA + + L + + + E+E+Q+ L ++++ + + G++ L+++
Sbjct: 5238 SAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQE- 5296
Query: 1649 LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQ 1708
++ + + + + + L+ + K E + ++ + W+ + L + Q
Sbjct: 5297 ITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQ 5356
Query: 1709 KEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIK 1768
E+ L+ L E + R ++ ++ L SEL+ + A ++ +K
Sbjct: 5357 LEE-LQILLTEATNHRQNIEKMAEEQKEKYLG-------LYTILPSELSLQLAEVALDLK 5408
Query: 1769 T-GKASIPLKELEQFNS--------------DIQKLLEPLEAEIQQGVNLKEEDFNKDMN 1813
+ +KE+EQ + D+ +L L+A+ V K + K +
Sbjct: 5409 IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQ--KVLG 5466
Query: 1814 EDNEGTVKELLQRGDNLQQRITDERKREEIKIKQ--QLLQTKHNALKDLRSQRRKKALEI 1871
E+ +G +L++ +Q+ + + + K+ +L + ++ ++ K
Sbjct: 5467 EELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAA 5526
Query: 1872 SHQWYQYKRQADDLLKCLDDIEKKLA-------SLPEPRDE--------RKIKEIDRELQ 1916
SH +Y + +LK ++ K LA S + R++ + KEID EL+
Sbjct: 5527 SHL-EEYNEMLELILKWIEKA-KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELE 5584
Query: 1917 KKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1976
E+L + + E Q+++ RE E Q+ +R +
Sbjct: 5585 AMTEKLQYLT----------SVYCTEKMSQQVAELGRETEE---------LRQMIKIRLQ 5625
Query: 1977 TMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKN 2036
+ +DM + E+ + AL + + L +P++ ++ + L +
Sbjct: 5626 NLQDAAKDM--------KKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLS 5677
Query: 2037 IKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFD 2096
+SL+ ++ + ++A V + L A +L + ++ +
Sbjct: 5678 EMESLKP---KVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQ 5734
Query: 2097 RSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVR 2156
+V ++ ++ ++K Q + A + + + + ++ELQ I + + + +
Sbjct: 5735 AAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATS--------NIQELQAQISRHEELAQ 5786
Query: 2157 TLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEV 2191
+ E+I +SK ++ K ++ L EV
Sbjct: 5787 KIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEV 5821
Score = 108 bits (269), Expect = 1e-22
Identities = 247/1404 (17%), Positives = 548/1404 (39%), Gaps = 185/1404 (13%)
Query: 318 LEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHT 377
++ ED++ + L+++ N D A +EV +W+ D L+ G + + + F
Sbjct: 7255 VQQQEDRT--NELLKAATNKD---IADDEVATWIQDCNDLLKGLGTVKDSL------FFL 7303
Query: 378 HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEK 437
HE LG +L ++ + +Q L+ L A ++
Sbjct: 7304 HE------------------LGEQL--KQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 7343
Query: 438 QSNLHRVLMDLQN--QKLKELNDWLTKTEE------RTRKMEEEPLGPDLEDLKRQVQQH 489
Q++L ++D + + L+ L W+ + EE + + + +E+LK Q+ +
Sbjct: 7344 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 7403
Query: 490 KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 549
+ DL+ R+N L + + + D+ ++++ L W+ I T +R+
Sbjct: 7404 SSMAPDLD----RLNELGYRLPLNDKEI---------KRMQNLNRHWSLISSQTTERFSK 7450
Query: 550 LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKD-----------QNEMLSSLQK 598
LQ LL+ Q E+ + +L + E + + ++ Q EM S Q
Sbjct: 7451 LQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQI 7510
Query: 599 LAVLKAD----LEKKKQSMGKLYSLKQDLLSTLKNKSV--TQKTEAWLDNFARCWDN--- 649
L + D LE+ + ++LK LLS + Q+ +D+ R W
Sbjct: 7511 LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYRE 7570
Query: 650 LVQKLEKSTAQIS----QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQ 705
+ +KL K ++S + + L Q + V +E++ ++ +
Sbjct: 7571 MAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTL--FDEVQFKEKVFLRQQGSYILTVEAG 7628
Query: 706 KKRQITVDSEIRKRLDVDITELHS-WITRSEAVLQSPEFAIF------RKEGNFSDLKEK 758
K+ ++ DS L ++ E+ W + S + + + F + E +D EK
Sbjct: 7629 KQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 7688
Query: 759 VNAIEREKAEKF--------------RKLQDASRS------AQALVEQMVNEGVNADSIK 798
+ +++ ++ ++L++A S +L++ ++ ++AD I
Sbjct: 7689 LRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDIS 7748
Query: 799 QASEQ---LNSRWIEFCQLLS-------ERLN-WLEYQNNIIAFYNQLQQLEQMTTTAEN 847
+E+ L +W E C LS ERLN W + L Q+E + +
Sbjct: 7749 ILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGD 7808
Query: 848 WLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 907
L I+ + ++ I ++ +L + ++ + +S A + ++
Sbjct: 7809 IL-IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASE--------IEYKL 7859
Query: 908 VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQL-SVT 966
+ ++ + + AR K+L+ + + + MS++RTW+ E++L+ P +
Sbjct: 7860 GKVNDRWQHLLDLIAARVKKLKETLVAVQQL--DKNMSSLRTWLAHIESELAKPIVYDSC 7917
Query: 967 DYEIMEQRLGELQALQSSLQEQQSG----LYYLSTTVKEMSKKAPSEISRKYQSEFEEIE 1022
+ E ++++L E Q LQ +++ +G L + + A Q ++
Sbjct: 7918 NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 7977
Query: 1023 GRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSE---- 1078
RW+ + + +E K+EE +K + + W+ E A S
Sbjct: 7978 RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-----SERTAAFPSSSGVIY 8032
Query: 1079 -ILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHM 1137
+ K++LK+ + L +N+ +++ E + A L+ + E N +WD++
Sbjct: 8033 TVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL 8092
Query: 1138 CQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMK 1197
++V + LK + + + + W+T+ + + + E+ + ++Q ++++K
Sbjct: 8093 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL--TNIEHFSECDVQAKIKQLK 8150
Query: 1198 RAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTR-------- 1249
++E K++ + +I ++ P+ +++EL+ L Q + R
Sbjct: 8151 AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 8210
Query: 1250 -----------LNGKCKTLEEVWAC----WHE-----LLSYLEKANKWLNEVE--FKLKT 1287
L+ + LE+ A WH+ LLS +N L+ + ++
Sbjct: 8211 IRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERS 8270
Query: 1288 TENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRW 1347
+ P + I D +L R E + R L +G + +
Sbjct: 8271 GRDTPASVDSIPLEWDHDYDLSRDLESAMS--RALPSEDEEGQDDKDFYLRGAVGLSGDH 8328
Query: 1348 RELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQ 1407
L + + K L+ S Q+TE + + +D Y+ + + +
Sbjct: 8329 SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVK 8388
Query: 1408 KIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDV--AQKKLQDVSMKFRLFQKPANFEQ 1465
+++ L E SL + + V+ + ++ AQ +++ MK L QK F
Sbjct: 8389 RLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNL-QKWQQFNS 8447
Query: 1466 RLQESKMILDEVKMHLPALE--TKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGR 1523
L L + + L L+ S + + ++ Q+ L K++ K+ + +
Sbjct: 8448 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 8507
Query: 1524 QIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWL 1583
+ Q E+ ++L +R++ + ++ + + + E + L+ L + + + L L
Sbjct: 8508 EFTQADSKES-RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLML 8566
Query: 1584 AATDMELTKRSAVEGMPSNLDSEV 1607
D +++ + + SNLD+E+
Sbjct: 8567 ENID---RRKNEIVPIDSNLDAEI 8587
Score = 65.9 bits (159), Expect = 7e-10
Identities = 74/330 (22%), Positives = 140/330 (42%), Gaps = 32/330 (9%)
Query: 314 PSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKD 373
PS+ E +DK F + V L +ALE + L A D + Q I +++
Sbjct: 8304 PSEDEEGQDDKDF---YLRGAVGLSGDHSALESQIRQLGKALDDSRFQ--IQQTENIIRS 8358
Query: 374 QFHT-------HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNS- 425
+ T ++GYM L + ++ +L KL ++EE + +NL ++
Sbjct: 8359 KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL-------KEEEESLPGFVNLHSTE 8411
Query: 426 --------RWECLRVASMEKQSNLHRVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPL 475
RWE L+ ++ K+ + + L Q N L + WL TEE +++ L
Sbjct: 8412 TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 8471
Query: 476 GPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDR 535
D++ ++ Q+++ K LQ+ ++ + + S+ ++ + + L+++L + R
Sbjct: 8472 STDIQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMNGR 8530
Query: 536 WANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 595
W +C E+ LLQD L++ Q E L + N+I E+L
Sbjct: 8531 WDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 8590
Query: 596 LQK-LAVLKADLEKKKQSMGKLYSLKQDLL 624
K L +K +L + + + L + LL
Sbjct: 8591 HHKQLMQIKHELLESQLRVASLQDMSCQLL 8620
Score = 52.4 bits (124), Expect = 8e-06
Identities = 152/832 (18%), Positives = 314/832 (37%), Gaps = 147/832 (17%)
Query: 2248 QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQD---KLENKLKQTNLQWIKVSRA 2304
Q++ L LP Q + + V P P ++ K++ K+ L+W++ +
Sbjct: 134 QIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAG 193
Query: 2305 LPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQET 2364
KQ IE +KD G+ + ++ + L + N+ N E F + ET
Sbjct: 194 ---KQTGIE--VKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAET 248
Query: 2365 EIA---------VQAKQPDVEEILSKGQHLYKEKPAT-------QPVKRKLEDLSSEWKA 2408
E+ V +PD + I++ K P Q L S +
Sbjct: 249 ELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANS 308
Query: 2409 VNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTK------------------ET 2450
V +E R ++ + T+ +V + K E
Sbjct: 309 VQNFKREDRVIFKEMKVWIEQFERDLTRA-QMVESNLQDKYQSFKHFRVQYEMKRKQIEH 367
Query: 2451 AISKLEMPSSLMLEVPALAD-FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQ 2509
I L L L+ + ++R + L DW LD+ + + +G E+ +++
Sbjct: 368 LIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALRE 427
Query: 2510 KATMQDLEQR-----RPQLEELITAAQNLK--NKTSNQEARTIITDRIERIQNQWDEVQE 2562
+ T+Q + + + +LE+ QN + ++ RT + I +Q +++ E
Sbjct: 428 EITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAE 487
Query: 2563 --HLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESW--KEGPY-TVDAIQKKIT 2617
H + +L+ M ++LE K +L A +KL+SW K G +V+ + +
Sbjct: 488 RFHFVSSTSELHLM---KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYV 544
Query: 2618 ETKQLAKDLRQWQTNVDVANDLALKLLR-DYSADDTRKVHMITENINASWRSIHKRVSER 2676
+ +K Q++ + A ++ D S ++ V A WR++ V
Sbjct: 545 SFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSV 604
Query: 2677 EAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDA---------------------- 2714
+ LEE ++ + AWL +AE N ++A
Sbjct: 605 RSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAG 664
Query: 2715 -----TRKERLLEDSKGVKELMK-QWQDLQGEIEAH-------------TDVYHNLD--- 2752
T E + D K L+ +W++L E++ + TD L
Sbjct: 665 NFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFA 724
Query: 2753 -ENSQKILRSLEGS--------DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQW 2803
E +K+ LE S D +++R+ M+ ++ + K + I E+ ++
Sbjct: 725 TEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITK--ESPQEEG 782
Query: 2804 KRLHLSLQELLVWL-QLKD----------------DELSRQAPIGGDFPAVQKQNDVHRA 2846
K + ++ +L L ++K+ +EL +Q + + ++ K N++
Sbjct: 783 KEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQ--MTSFYDSLGKINEIITV 840
Query: 2847 FKRE------LKTKEPVIMSTLETVRIFLT--EQPLEGLEKLYQEPRELPPEERAQNVTR 2898
+RE K K +++ E + LT E+ + ++K L ++ +
Sbjct: 841 LEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTR---- 896
Query: 2899 LLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 2950
L++Q +++ ++ + + DW++ ++ +++ +E+ EL+ LR A+
Sbjct: 897 -LQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQ 947
Score = 35.4 bits (80), Expect = 1.1
Identities = 32/140 (22%), Positives = 60/140 (42%), Gaps = 9/140 (6%)
Query: 2906 EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 2965
++ WE L ++ QR + E LER Q+ Q++ + K+ E+ G
Sbjct: 5939 DLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES 5998
Query: 2966 SLQDHLEKVKALRGEIAPLKENVSHV-NDLARQLTTLGIQLSPYN----LSTLEDLNTRW 3020
+ +H +AL EI L++ ++ + + LA +L + + P STL L R
Sbjct: 5999 QMAEH----QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 6054
Query: 3021 KLLQVAVEDRVRQLHEAHRD 3040
+++ + + L E D
Sbjct: 6055 STIRMKASGKRQLLEEKLND 6074
>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
[Homo sapiens]
Length = 8749
Score = 313 bits (803), Expect = 2e-84
Identities = 606/3124 (19%), Positives = 1211/3124 (38%), Gaps = 518/3124 (16%)
Query: 7 DEREDVQKKTFTKWVNAQFSKFGKQHI-ENLFSDLQDGRRLLDLLEGLTGQKLPKEKGST 65
DE+E VQK+TFTKW+N+ +K + ++LF D++DG +LL LLE L+GQKLP E+G
Sbjct: 23 DEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGRR 82
Query: 66 --RVHALNNVNKALRVLQNNN-------VDLVNIGSTDIVDGNHKLTLGLIWNIILHWQV 116
R+HA+ N+ AL+ L+ + LVNI STDI DG + LGL+W IIL++Q+
Sbjct: 83 MKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILYFQI 142
Query: 117 KNVMKNI-----------------------------MAGLQQTNSEKILLSWVRQSTRNY 147
+ + N+ + Q N++K LL WV+ +
Sbjct: 143 EELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQ 202
Query: 148 PQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEK 207
+ V +F SW G+A +++IH+ RP+L D +V +S + LE AF IA +LGI +
Sbjct: 203 TGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVK-GRSNRENLEDAFTIAETELGIPR 261
Query: 208 LLDPEDVDTTYPDKKSILMYITSLFQVLP--QQVSIEAIQEVEMLPRPPKVT-------K 258
LLDPEDVD PD+KSI+ Y+ + P S + ++ E+LP P +
Sbjct: 262 LLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKR 321
Query: 259 EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 318
E+ + +Q L + S+ + +++S+ + + Y H
Sbjct: 322 EDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHR 381
Query: 319 -------EAPEDKSFG---SSLMESEVNLDRYQTA-LEEVLSWLLSAEDTLQAQGEI--- 364
+A +S+ S L + + LD+ A L + +WL AE L+ + +
Sbjct: 382 DGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQV 441
Query: 365 -SNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLL 423
++ + H+ + + AH+ I + ++ + + D+ ++ E+ + +
Sbjct: 442 HEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYR--TRSVNGIPVPPDQLEDMAERFHFV 499
Query: 424 NSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLK 483
+S E L + ME +R+L L + K L W+ K R E ++
Sbjct: 500 SSTSE-LHLMKMEFLELKYRLLSLLVLAESK-LKSWIIKYGRR-------------ESVE 544
Query: 484 RQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGD---RWA 537
+ +Q + E+ EQ +V L + ++ G A E +K + + +W
Sbjct: 545 QLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEA--ENVMKFMNETTAQWR 602
Query: 538 NICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKI---------------- 581
N+ +L++++ W R AWL + E +N+
Sbjct: 603 NLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQ 662
Query: 582 -HTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWL 640
HT N ++ + ++ + DL KQ + L ++L +K + + +
Sbjct: 663 QHTAMNDAGNFLIETCDEM--VSRDL---KQQLLLLNGRWRELFMEVKQYAQADEMDRMK 717
Query: 641 DNFARC-----------WDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQ 689
+ C L + LE S + + + + VM+ + T+
Sbjct: 718 KEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTA 777
Query: 690 ILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKE 749
L+ P + K S+++++L + E +S + L P + ++
Sbjct: 778 HLITKES-----PQEEGKEMFATMSKLKEQL-TKVKECYSPLLYESQQLLIPLEELEKQM 831
Query: 750 GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWI 809
+F D K+N I + + + AL +Q E + A ++ + +
Sbjct: 832 TSFYDSLGKINEI--------ITVLEREAQSSALFKQKHQELL-------ACQENCKKTL 876
Query: 810 EFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKIC 869
+ S+ + +N++ ++Q + Q+ + + T +++ ++
Sbjct: 877 TLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLM 936
Query: 870 KDEVNRLSGLQPQIER-LKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKEL 928
K + + ++E+ L+I L+EKG L F+ ++V + A K
Sbjct: 937 K----KFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRV---LNAFLKAC 989
Query: 929 QTIFDTLPPMRYQETMSAIR----TWVQ-QSETKLSIPQLSVTDYE------IMEQRLGE 977
+ D LP Q A+R W Q E + L + D E +E+ E
Sbjct: 990 DELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKI-DVEKNRFLASVEECRTE 1048
Query: 978 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEI---------------- 1021
L ++ L Q+ + S K P + K EE+
Sbjct: 1049 LDR-ETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGT 1107
Query: 1022 -EGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLK----EEWPALGD 1076
K+L + + +KL E +K + + W++ + LK E
Sbjct: 1108 CHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANH 1167
Query: 1077 SEILKKQLKQCRLLVS----DIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNT 1132
E+ K+ +++ R V+ + ++ L + E + + + + + ++L + K L T
Sbjct: 1168 GEV-KRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVT 1226
Query: 1133 QWDHMCQQV------YARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP 1186
+ + + KE +K LE+ +S K++ E E + E +
Sbjct: 1227 LLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLF---------- 1276
Query: 1187 DELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA-------PPVAQEALKKELETL 1239
E ++ QQK ++ V IAQA P E L+K TL
Sbjct: 1277 --------EAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTL 1328
Query: 1240 ---------------TTNYQWLCTRLNGK--CKTLEEVWACWHELLSY--LEKANKWLNE 1280
T +W N + + L + + LS+ LE + L +
Sbjct: 1329 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQ 1388
Query: 1281 VEFKLKTTENIPGGAE----EISEVLDSLEN---LMRHSEDNPNQIRILAQTLTDGGVMD 1333
+ K TE+I AE E SE+ +N L + ++ Q++ L TL +
Sbjct: 1389 TKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTM 1448
Query: 1334 ELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI 1393
E++ + + F S + L ++K L S+ + + I+ ++ I+ +L++ +
Sbjct: 1449 EMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIV 1508
Query: 1394 ADKVDAAQMPQ-----EAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQ 1448
+ +A Q E+ +I++ LT EE+++H Q E +L + QK +
Sbjct: 1509 GLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGT--ILGHLSQQQKFEE 1566
Query: 1449 DVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSL 1508
++ ++ Q + FE +L +K+ A ET V QE ++L ++L
Sbjct: 1567 NLR---KIQQSVSEFEDKLAV------PIKICSSATETYKVLQE--------HMDLCQAL 1609
Query: 1509 SEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKL 1568
+ S + + R++V N + AL+ Y ++ + ER+ LE L
Sbjct: 1610 ESLSSAITAFSASARKVV------NRDSCVQEAAALQQQYEDILRRAKERQTALENLLAH 1663
Query: 1569 SRKMRKEMNVLTEWLAATDMELTK-RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSI 1627
+++ KE++ WL + + + + ++ E+ +A Q E+ Q +
Sbjct: 1664 WQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKL 1723
Query: 1628 TEVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDH 1686
++ E+L +V K + +++ L L+ W + + +N L + FD+ +
Sbjct: 1724 LQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLS 1783
Query: 1687 ITKWIIQADTLLDESEKKKPQQKEDVLKRLK---AELNDIRPKVDSTRDQAA-------- 1735
+ WI + L + + + L R K AE+ + ++ S + A
Sbjct: 1784 FSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRA 1843
Query: 1736 ---NLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEP 1792
+L+ + + C +L E + R A+SH L E Q ++ + +L
Sbjct: 1844 EDLHLLQGKAEDCFQLFEEASQVVERRQLALSH----------LAEFLQSHASLSGILRQ 1893
Query: 1793 LE--AEIQQGVNLKEED-FNKDMNE--DNEGTVKELLQRGDNL------QQRITDERKRE 1841
L E +N E D KD+N+ N ++ D + +I +R
Sbjct: 1894 LRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRT 1953
Query: 1842 EIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL--ASL 1899
+ L + +++L ++ +A ++ ++ Q ++LLK ++DIE++ L
Sbjct: 1954 SCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERL 2013
Query: 1900 PEPRDE------RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQ--IQLSKR 1951
EP + R +++ EL + EL ++ +A+ +++ A A E + +L
Sbjct: 2014 KEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVT 2073
Query: 1952 WREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEIS---YVPSTYLTEITHVSQALL 2008
W + + + + I +RE + LE + V T + + + A
Sbjct: 2074 WDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFS 2133
Query: 2009 EVEQLLNAPDLCAKDFE--------------------------DLFKQEESLKNIKDSLQ 2042
+ E N + KD + D+ + ++ + L+
Sbjct: 2134 KHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLE 2193
Query: 2043 QSSGRIDIIHSKKTAALQSATPVER------VKLQEALSQLDFQWEKVNKMYKDRQGRFD 2096
++ R+ + S L + +E ++ E +S LD + ++ K+ +
Sbjct: 2194 ENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLD-NHLRAEELLKEFESEVK 2252
Query: 2097 RSVEKWRRFHYDIKIFNQWLTEAE-----QFLRKTQIPENWEHAKYKWYLKE--LQDGIG 2149
+ H + + E QF+ + + + EHAK + + L+D
Sbjct: 2253 NKALRLEELHSKVNDLKELTKNLETPPDLQFI-EADLMQKLEHAKEITEVAKGTLKDFTA 2311
Query: 2150 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVC---KQLSDRKKRLEEQK 2206
Q V + +N +I +K + S+ +N E C K++ D +K L+ Q+
Sbjct: 2312 QSTQVEKFIN----DITTWFTKVEESL-------MNCAQNETCEALKKVKDIQKELQSQQ 2360
Query: 2207 NILSEFQRDLNEFVLWLEEAD----------------------NIASIPLEPGKEQQLKE 2244
+ +S Q +LN A+ + L+ E+ E
Sbjct: 2361 SNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSE 2420
Query: 2245 KLEQV---------------------KLLVEELPLRQGILKQLNETGGPVLVSAPISPEE 2283
+++ K+L +L Q IL +++ G + A ++ E
Sbjct: 2421 SMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSD--GQSKLDA-VTQEG 2477
Query: 2284 QDKLENKLKQ--TNLQWIKVSRALPEKQGEIEAQIKDLGQLE---KKLEDLEEQLNHLLL 2338
Q + KQ +++Q ++++A E Q ++ +KD L+ +L E+Q L L
Sbjct: 2478 QTLYAHLSKQIVSSIQ-EQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNL 2536
Query: 2339 WLSPIRNQLEIYNQPNQEGPFDVQETEI--------AVQAKQPDVEEILSKGQHLYKE-- 2388
W+ + + N + ++ E+ + A + ++++ +GQ L +E
Sbjct: 2537 WIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGH 2596
Query: 2389 ----------------KPATQPVKRKLEDLS---SEWKAVNRLLQEL----RAKQPDLAP 2425
+ + K KL E +A+ LQ + +A Q LA
Sbjct: 2597 GAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLAC 2656
Query: 2426 GLTTIGASPT--QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTD--- 2480
+T+G+ T + ++ + ++ K KL M ++ AL N+ +
Sbjct: 2657 AESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNM--AIGKGEQALRSSNKEGQRVIQTQL 2714
Query: 2481 ------WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLE----------QRRPQLE 2524
W ++ + +Q + + N+ + ++ Q +E Q +P L+
Sbjct: 2715 ETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLK 2774
Query: 2525 ELITAAQNLKNKTSNQEARTIITDRI---------------------ERIQNQWDEVQEH 2563
E +L++ S E T R+ E ++ Q++++
Sbjct: 2775 EKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTV 2834
Query: 2564 LQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLA 2623
+ + +++ E++KD +L+A E L A+ +L W + A QKK+++ K+L
Sbjct: 2835 AKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELI 2894
Query: 2624 KDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEET 2683
+ + LA ++ ++ +A +H + + A W+ V + ++ LE
Sbjct: 2895 DSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLE-- 2952
Query: 2684 HRLLQQFPLDLEKF---LAWLTEA-ETTANVLQDATRKERLLEDSKGVKELMKQWQDLQG 2739
L+ Q L ++F +A L +A E + +L+ ++ LLE +E+++ W Q
Sbjct: 2953 -NLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQE 3011
Query: 2740 EIEA 2743
++A
Sbjct: 3012 ILDA 3015
Score = 214 bits (544), Expect = 2e-54
Identities = 375/2040 (18%), Positives = 825/2040 (40%), Gaps = 215/2040 (10%)
Query: 770 FRKLQDASRSAQALVEQMVNEG------VNADSIKQASEQLNSRWIEFCQLLSERLN--- 820
++ L+ + Q + Q++++G ++ ++ QL W+ +S+ L+
Sbjct: 6661 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 6720
Query: 821 -----WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---E 872
W YQ+ + LQ + E W + T P E ++ L + E
Sbjct: 6721 TILKHWTRYQSESADLIHWLQSAKDRL---EFWTQQSVTVPQELEMVRDHLNAFLEFSKE 6777
Query: 873 VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTI- 931
V+ S L+ + Q + LK+ L ++ + + + +++ A +++L +
Sbjct: 6778 VDAQSSLKSSVLSTGNQLLRLKKVDTAT--LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 6835
Query: 932 FDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD---YEIMEQRLGELQALQSSLQEQ 988
D LP + +S + +W+ E + + ++ + Y+ + + L + + + + +
Sbjct: 6836 MDKLPS---RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCK 6892
Query: 989 QSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGR----WKKLSSQLVEHCQKLEEQMN 1044
Q + +++ +V ++S + E R +++F E G W+ L + E Q LE +
Sbjct: 6893 QLTVDFVNQSVLQISSQ-DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 6951
Query: 1045 KLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV 1104
+ +N++Q LK W + LK++ +GD ++ LK C+ L I+ + + +
Sbjct: 6952 SWSEYENNVQCLKTWFETQEKRLKQQH-RIGDQASVQNALKDCQDLEDLIKAKEKEVEKI 7010
Query: 1105 NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSE 1164
+ G + + + +S + + L+EL W ++ V K LK L++ S + +
Sbjct: 7011 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK 7070
Query: 1165 MHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA 1224
++ ++ +A + + +Q V+ ++ +++ +++E ++ N ++ +
Sbjct: 7071 INSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 7130
Query: 1225 PPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1284
P E L L+ + + L + + ++ + + W Y ++ + + E +
Sbjct: 7131 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 7190
Query: 1285 ----LKTTENIPGGAEEISEVLDSLENLMRHS---EDNPNQIRILAQTL---TDGGVMDE 1334
LK N +E++ + +L++ +D+ + L + L D
Sbjct: 7191 TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 7250
Query: 1335 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI- 1393
+ +++L + + L + ++Q L+ + + KSL ++ + ++ L
Sbjct: 7251 IQSDQL-SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7309
Query: 1394 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1453
+ D + + + ++++ + ++ + N E R L D K++Q+++
Sbjct: 7310 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN---ELGYR-LPLNDKEIKRMQNLNRH 7365
Query: 1454 FRLF-----QKPANFEQRLQESKMILDEVKMHLP---------ALETKSVEQEVVQSQLN 1499
+ L ++ + + L + + L++ + + A+E Q +++ Q
Sbjct: 7366 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRA 7425
Query: 1500 HCVNLYKSLSEVKSEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTER 1558
H L+++ + ++ +I G++++++ Q ++ E + ++T L + + + +R
Sbjct: 7426 H--ELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 7483
Query: 1559 KQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD-SEVAWGKATQKE- 1616
+ ++ ++ ++ R+ L +WL ++ S + +P L + + + KE
Sbjct: 7484 RGIIDSQIRQWQRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 7541
Query: 1617 --IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 1674
+ +Q ++ ++ + L + E ++ +L+ + W + + R EE L
Sbjct: 7542 VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL 7601
Query: 1675 KHMETFDQNVDHITKWIIQADTL--LDESEKKKPQQKEDVLKRLKAE---LNDIRPKVDS 1729
K E ++ + AD+L L +KK Q D + L AE ++ V S
Sbjct: 7602 KDWEKCEKGI---------ADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGS 7652
Query: 1730 TRDQAANLMANRGDHCRKLVEPQISELNHR-------FAAISHRIKTGKASIP--LKELE 1780
D L + + IS LN R + + H++ + I L E
Sbjct: 7653 WTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWA 7712
Query: 1781 QF---NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVK-------ELLQRGDNL 1830
F N ++ + L +E+++ Q ++ E+ + + +D + + +L Q G+ L
Sbjct: 7713 VFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERL 7772
Query: 1831 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1890
+ + E K EI+ K + + L DL + R KK E Q + L L
Sbjct: 7773 A-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 7831
Query: 1891 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAA 1938
IE +LA P D +EI R+L +++E + + + G++ D A
Sbjct: 7832 HIESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 7890
Query: 1939 MAVEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVP 1993
E IQ L +RWR I + RRL EET + +
Sbjct: 7891 TDAECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK---------- 7932
Query: 1994 STYLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRID 2049
+L + + L E+ P + E+L K E + + + L Q ++
Sbjct: 7933 --FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LE 7986
Query: 2050 IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI 2109
+I+ + + L++ + + + +W+ + K R + + F
Sbjct: 7987 LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 8046
Query: 2110 KIFNQWLTEAEQFLRKTQIPENWE---HAKYKWYLKELQDGIGQRQTVVRTLNATGEEII 2166
WLTE + L+ T I E AK K LK Q I + + A GE++I
Sbjct: 8047 DSILVWLTEMD--LQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLI 8103
Query: 2167 QQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA 2226
++S DA+I++E+L L QEV ++ K+L L + + DL++ L LE++
Sbjct: 8104 EKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDS 8161
Query: 2227 DNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQD 2285
++ + L L L L Q + + + P V S P+ +
Sbjct: 8162 AALSDLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDY 8218
Query: 2286 KLENKLKQTNLQWIKVSRALP--EKQGEIEAQIKDLGQL-----------EKKLEDLEEQ 2332
L L+ +SRALP +++G+ + G + E ++ E
Sbjct: 8219 DLSRDLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENA 8272
Query: 2333 LNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPAT 2392
+ + S + +Q+ + + F +Q+TE +++K P E+ +
Sbjct: 8273 IKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSY 8322
Query: 2393 QPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAI 2452
+ + L + SS +V RL +L+ ++ L PG + ++ TQT ++ + + + A+
Sbjct: 8323 KGYMKLLGECSSSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQAL 8381
Query: 2453 SK-LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKA 2511
SK L M +L +D N W L D L+Q+ + + + D++ I I K K
Sbjct: 8382 SKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKE 8439
Query: 2512 TMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQL 2571
+ ++ R+ + + + + ++E+R + DR+ ++ +WD V L+ R
Sbjct: 8440 LQKAVDHRKAIILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR--- 8494
Query: 2572 NEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKD 2625
+L+D+ + E L ++ K +D+ +Q + Q+ +
Sbjct: 8495 -GLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHE 8553
Query: 2626 LRQWQTNVDVANDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 2681
L + Q V D++ +LL + D KVH+I + + + + + E E L+
Sbjct: 8554 LLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 8613
Score = 203 bits (517), Expect = 2e-51
Identities = 525/2932 (17%), Positives = 1093/2932 (37%), Gaps = 475/2932 (16%)
Query: 319 EAPEDKSFGS-SLMESEVNLDRYQTALE-----EVLSWLLSAEDTLQAQGEISNDVEVVK 372
E ++K G +++ SE++L + AL+ ++ + E + E+S ++ +
Sbjct: 5308 EEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLA 5367
Query: 373 DQFHTHEGYMMDLTAHQGRVGNILQ-------LGSKLIGTGKLSEDEETEVQEQMNLLNS 425
T LT + + N++Q LG +L G + + VQ+ +
Sbjct: 5368 KDLTTI------LTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQ 5421
Query: 426 RWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQ 485
+ L + K + LH+ + +L +LN + EE LE + +
Sbjct: 5422 LGKPL-AKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEM---------LELILKW 5471
Query: 486 VQQHKVLQEDL----EQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVL--------- 532
+++ KVL Q+R + H ++ + D A+ E+L+ L
Sbjct: 5472 IEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKM 5531
Query: 533 GDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEM 592
+ A + R TE+ +++ L Q ++ F A L + + A+ + T +
Sbjct: 5532 SQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGR 5591
Query: 593 LSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQ 652
LS LK L ++ + ++ SLK + + +S + E + + C L
Sbjct: 5592 LS-------LKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAAL-- 5642
Query: 653 KLEKSTAQISQAVTTTQPSLTQTTVM--ETVTTVTTREQILVKHAQEELPPPP------P 704
+L++ +++ Q Q ++ Q V+ E Q L++ A E+ P
Sbjct: 5643 RLQEEASRL-QHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQ 5701
Query: 705 QKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFA-IFRKEGNFSDLKEKVNAIE 763
+ + QI+ E+ +++ ++ S ++ + + + A + L E ++
Sbjct: 5702 ELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLD 5761
Query: 764 RE-----KAEKFRKLQDASRSAQAL---VEQMVNEGVNADSIKQASEQLNSRWIEFCQLL 815
E A + A R L E+ EG N++ + C+
Sbjct: 5762 GELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA----------CRSP 5811
Query: 816 SERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNR 875
S N N IA+Y L T A KI P+T + + L+ +
Sbjct: 5812 SPVANTDASVNQDIAYYQALSAERLQTDAA----KIHPSTSASQEFYEPGLE--PSATAK 5865
Query: 876 LSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTL 935
L LQ E LK V S+ Q +T+++ L
Sbjct: 5866 LGDLQRSWETLK----------------------------NVISEKQ------RTLYEAL 5891
Query: 936 P-PMRYQETMSAIRTWVQQSETKLS-------IPQLSVTDYEIMEQRLGELQALQSSLQE 987
+YQ+++ +I T ++ E KLS P+ + +++ + + E+ LQ + E
Sbjct: 5892 ERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQAL---MDEILMLQDEINE 5948
Query: 988 QQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLR 1047
QS L V E + P+E QS + R + + Q LEE++N
Sbjct: 5949 LQSSL--AEELVSESCEADPAE-QLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL 6005
Query: 1048 KIQNHIQTLKKWMAEVDVFLKEEW----PALGDSEI--------LKKQLKQCRLLVSDIQ 1095
+ Q Q L+++ E D + W A D+ + ++ QL C+ ++ +I+
Sbjct: 6006 EEQRQEQALQRYRCEADEL--DSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIE 6063
Query: 1096 TIQPSLNSVN--------EGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1147
+L+ ++ EG K+EAE +L +L+ L + + ++ ++
Sbjct: 6064 QKVVALSELSVHNENLLLEGKAHTKDEAE-----QLAGKLRRLKGSLLELQRALHDKQLN 6118
Query: 1148 LKGGLEKTVSLQKDLSE-----MHEWMTQAEEEYLE-RDFEYKTPDELQKAVEEMK---- 1197
++G ++ DL+ + EW+ QA + + R + EL++ + E K
Sbjct: 6119 MQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLR 6178
Query: 1198 ----RAKE-----------------------------EAQQKEAKVKLLTESVNSVIAQA 1224
R +E E E ++++ ES++ +
Sbjct: 6179 SVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTK 6238
Query: 1225 PPVAQEALKKELETL--------------------TTNYQWLCTRLNGKCKTLEEVWA-- 1262
+ Q L++E E + T + + + L+G + EEV +
Sbjct: 6239 QKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQS 6298
Query: 1263 ---------CWHELLSYLEKANKWLNEVEFKL-KTTENIPGGAEEI---SEVLDSLENLM 1309
+L + + WL++VE +L T +P E E+L +++
Sbjct: 6299 GGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEIL--AKDIK 6356
Query: 1310 RHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQ 1369
SE+ + +Q + G ++I + L R L +R +++ +Q
Sbjct: 6357 EMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQIL 6416
Query: 1370 ETEKSLHLIQESLT---FIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKH 1426
+ L ++ SL +I Q A + ++ A Q+ + Q+ + L + + E+K+
Sbjct: 6417 NFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQI-EAIQQAEDGLKEFDAGIIELKRR 6475
Query: 1427 NQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPAN--------FEQRLQESKMILDEVK 1478
+ Q + ++ Q ++ M + N +E+ LQ+ +L+ +
Sbjct: 6476 GDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQ 6535
Query: 1479 MHLPALETKSVE-QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKEL 1537
+ + V +E +Q L+ ++ L E + + +K+T+ EL
Sbjct: 6536 EKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTEL 6595
Query: 1538 DERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVE 1597
+ +A+ ++ G +LE L+ + ++ L+ L + + VE
Sbjct: 6596 MAQASAVLKRAHKRGV-------ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVE 6648
Query: 1598 GMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWI 1657
L + + + + + + L + + G+ L + + +E +L+ L W+
Sbjct: 6649 ENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD--LESQLNQLGECWL 6706
Query: 1658 AVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD---ESEKKKPQQKEDVLK 1714
+ T++ + L+ L KH + + W+ A L+ + PQ+ E V
Sbjct: 6707 SNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRD 6766
Query: 1715 RLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASI 1774
L A L + +VD+ +++++ G+ +L + + L + I + +I
Sbjct: 6767 HLNAFL-EFSKEVDAQSSLKSSVLST-GNQLLRLKKVDTATLRSELSRIDSQWTDLLTNI 6824
Query: 1775 PLKELEQFNSDIQKL-LEPLEAEIQQGVNLKEEDFNKDMNEDN------EGTVKELLQRG 1827
P + + + KL +E+ ++L E KD EDN + E LQ+
Sbjct: 6825 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKD--EDNIKNSIGYKAIHEYLQKY 6882
Query: 1828 D------NLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQ----------------RR 1865
N +Q D + ++I Q +++K + D Q +
Sbjct: 6883 KGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEK 6942
Query: 1866 KKALE-ISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNA 1924
+ LE + W +Y+ L + EK+L D+ ++ ++ Q ++ + A
Sbjct: 6943 IQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKA 7002
Query: 1925 VRRQAEGLSEDGAAMA----------VEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVR 1974
++ E + ++G A+ V T +L + W ++ Q + L + +V
Sbjct: 7003 KEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKIL----LKSVL 7058
Query: 1975 EETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESL 2034
++ S++ ++ L+E L+ L E + Q ++L
Sbjct: 7059 DQW----------------SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNL 7102
Query: 2035 KNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGR 2094
+N++D L++ + S L+ P L L +++ +W + + ++
Sbjct: 7103 QNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQS 7162
Query: 2095 FDRSVEKWRRFHYDIKIFNQWLTEAE----QFLRKTQIPENWEHAKYKWY--LKELQDGI 2148
++ W+R+ K + + E + L+ + + W +L G+
Sbjct: 7163 SKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGL 7222
Query: 2149 GQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRW----QEVCKQLSDRKKRLEE 2204
G + + L+ GE++ QQ + AS +Q SL+ Q +CKQ + + + +
Sbjct: 7223 GTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLD 7282
Query: 2205 QKNILSEFQRDLNEFVLWLEEADNI--ASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGI 2262
+ F + L W+ EA+ I P ++E++E++K + +
Sbjct: 7283 YET----FAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPD 7338
Query: 2263 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 2322
L +LNE G P++ +E +++N N W +S E+ ++++ +
Sbjct: 7339 LDRLNELG----YRLPLNDKEIKRMQN----LNRHWSLISSQTTERFSKLQSFLLQHQTF 7390
Query: 2323 EKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQA----KQPDVEEI 2378
+K E E +L +L + N + + Q QA +Q + I
Sbjct: 7391 LEKCETWME-------FLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSI 7443
Query: 2379 LSKGQHLYKEKPATQ--PVKRKLEDLSSEWKAVNRLLQELRA--------------KQPD 2422
+ GQ L ++ KL LS++W+ V R Q+ R
Sbjct: 7444 IIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEK 7503
Query: 2423 LAPGLTTIGASPTQTVTLVTQPVVTKETAISK--------LEMPSSLMLEVPA------- 2467
L L + P + V P+ T + L S +L V A
Sbjct: 7504 LRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLS 7563
Query: 2468 ------------LADFNRAWTE---------------LTDW-------LSLLDQVIKSQR 2493
LA+ W L DW L+++ ++
Sbjct: 7564 ADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKK 7623
Query: 2494 VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTS---NQEARTIITDRI 2550
+ L D +E + ++ ++LE + +T LK+ S + + +I+ +R+
Sbjct: 7624 KLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERV 7683
Query: 2551 ERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVD 2610
E +Q QW+E+ L RRQQ+ E L + + E +E + L Q +K+ + G ++
Sbjct: 7684 ELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVS--QNGDILIE 7741
Query: 2611 AIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIH 2670
+ +K+ K +++ Q N + +L + ++ +N W+ +
Sbjct: 7742 EMIEKL--KKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLL 7799
Query: 2671 KRVSEREAALEETHRLLQQFPLDLEKFLAWLT--EAETTANVLQDATRKERLLEDSKGVK 2728
++ R L+ET +QQ ++ WL E+E ++ D+ E ++
Sbjct: 7800 DLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEE-------IQ 7852
Query: 2729 ELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG-SDDAVL--LQRRLDNMNFKWSEL 2785
+ + Q+LQ +IE H+ ++ + +L + + DA +Q+ N++ +W +
Sbjct: 7853 RKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNI 7912
Query: 2786 RKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHR 2845
S+ R +E + W++ WL+ + + + G + +++
Sbjct: 7913 CAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFE 7972
Query: 2846 AFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAE 2905
AF+R++ + L LE + ++ R L E R + L++
Sbjct: 7973 AFQRQV-------------------HECLTQLELINKQYRRLARENRTDSACS-LKQMVH 8012
Query: 2906 EVNTEWEKLNLHSADWQRKIDETLERLQELQEATD-------ELDLKLRQAE 2950
E N W+ L R++ + + +E + A D E+DL+L E
Sbjct: 8013 EGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE 8064
Score = 188 bits (477), Expect = 1e-46
Identities = 535/2989 (17%), Positives = 1112/2989 (37%), Gaps = 447/2989 (14%)
Query: 329 SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQ--GEISNDVEVVKDQFHTHEGYMMDLT 386
+L + L ++ ++ W+ E+ + GE + K++ H E ++ +L
Sbjct: 2516 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2575
Query: 387 AHQGRVGNILQLGSKLIGTGKLSEDE----ETEVQEQMNLLNSRWECLRVASMEKQSNLH 442
A + + + Q G L G + E + NLL E LR + Q H
Sbjct: 2576 AARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQE--H 2633
Query: 443 RVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPD-LEDLKRQVQQHKVLQEDLEQEQV 501
L + L+ + W+ ++R E D LE Q+Q +++ + E V
Sbjct: 2634 EAL----EEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE---V 2686
Query: 502 RVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 561
++N SS ++ QL+ L + WA+I + L+ ++ +W
Sbjct: 2687 KLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYV 2746
Query: 562 EEQCLFSAWLSEKEDAVNKI--HTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL 619
E + W+ + + G K++ +L LQ + ++ E +++ +L +
Sbjct: 2747 ERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSIL---SEAEDHTRALHRLIAK 2803
Query: 620 KQDLLSTLKNKS----VTQKTEAWLDNFARCWDNLVQKLEK----------STAQISQAV 665
++L +++S ++ + ++ ++K+E+ + + + +
Sbjct: 2804 SRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWL 2863
Query: 666 TTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDIT 725
+ + L + + M ++ T ++ +K + + R ++ E+++
Sbjct: 2864 HSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGC 2923
Query: 726 EL-HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV 784
EL H+ + A + E ++F+ + +L ++ E+E + + +L+ A AL+
Sbjct: 2924 ELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALL 2983
Query: 785 EQMVN-----EGVNADS------------------IKQASEQLNSRWIEFCQLLSERLNW 821
+ EG N D + +E L S+ E C+ + +
Sbjct: 2984 KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY 3043
Query: 822 LEYQNNIIAFYNQL------------QQLEQMTTTA----ENWLKIQPTT-------PSE 858
+ +I YN L Q L+Q A + WL T P
Sbjct: 3044 SGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQN 3103
Query: 859 PTAIKSQLKICKDEVNRLSGLQPQIERLK-----IQSIALKEKGQGPMFLDADFVAFTNH 913
+ + + L+ ++ ++ Q ++ + + ++ KEK +G + A A
Sbjct: 3104 ISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKG---IQAKVTAAKED 3160
Query: 914 FKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQ 973
+K S++ +E L+ + + ++ + I+ W+ S+T+ + + S Y++ +
Sbjct: 3161 WKNFHSNLHQKESALENL--KIQMKDFEVSAEPIQDWL--SKTEKMVHESSNRLYDLPAK 3216
Query: 974 RLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPS-----EISRKYQSEFEEIEGRWKKL 1028
R E Q LQS L+E ++ + + +KA S+ ++ ++ ++ L
Sbjct: 3217 RR-EQQKLQSVLEE----IHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLAL 3271
Query: 1029 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1088
S+ E +L+ + + + I+ L+ WM + L D +L + +
Sbjct: 3272 SNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLE 3331
Query: 1089 LLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEAL 1148
L+S Q + + + G+ + PE ++ +L+ + W + K L
Sbjct: 3332 ALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQL 3391
Query: 1149 KGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE- 1207
+G L K S Q + + WM D ++ + E +R E + K
Sbjct: 3392 EGALSKWTSYQDGVRQFSGWM-----------------DSMEANLNESERQHAELRDKTT 3434
Query: 1208 --AKVKLLTESVNSV--------IAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1257
K KLL E V S + A + EL+ L Y+ + R
Sbjct: 3435 MLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKS 3494
Query: 1258 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1317
E++ E L+ WL + + KL + G A L L+ L H +
Sbjct: 3495 EKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQA 3554
Query: 1318 QIRILAQTLTD---GGVMD------ELINEELETFNSRWRELHEE---AVRRQKLLEQSI 1365
+ + T D G+ E + ++ + + R E + V + +L+EQ
Sbjct: 3555 LLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKF 3614
Query: 1366 QSAQE-----TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISL 1420
Q E EK H +++ AY + + QE + + +
Sbjct: 3615 QQVDEWLKTAEEKKWH----------EEVTAYRDEVEEVGARAQEI--LDESHVNSRMGC 3662
Query: 1421 EEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANF----EQRLQESKMILDE 1476
+ + ++ + +VL QI ++++Q + +++ + + +D+
Sbjct: 3663 QATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDK 3722
Query: 1477 VKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1536
V + + K++E + + H S +KS E + + + + + KE
Sbjct: 3723 VDTVMMGKKLKTLEVLLKDMEKGH--------SLLKSAREKGERAVKYLEEGEAERLRKE 3774
Query: 1537 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1596
+ + + LK EL + V + LEK L L+++ + LT+W+A L
Sbjct: 3775 IHDHMEQLK----ELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEP 3830
Query: 1597 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNW 1656
+ ++++ K+ Q+ + + +KS+ E GEAL ++ ++ ++DK+ L S++
Sbjct: 3831 KMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELV--QDVTLKDKIDQLQSDY 3888
Query: 1657 IAVTSRAEEWLNLLLEYQKHMETFD--------QNVDHITKWIIQ--------------- 1693
+ S + + + ++ + Q DH+ + Q
Sbjct: 3889 QDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSA 3948
Query: 1694 ----ADTLLD--ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRK 1747
A + E E +K ++D L++ +A L+ ++P ++ + +
Sbjct: 3949 ICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSR---------- 3998
Query: 1748 LVEPQISELNHRFAAISHRIKT------GKASIPLKELEQFNSDIQKLLEPLEAEIQQGV 1801
I ++ H F A+ + +T + ++ DIQ+ + +E ++ Q
Sbjct: 3999 --AEAIKQVKH-FRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQ 4055
Query: 1802 NLKE--EDFNKDMNE------DNEGTVKELLQRGDNLQQRITDERKRE------EIKIKQ 1847
NL + E+ +E D + ++ + +R L+ I + +++ KQ
Sbjct: 4056 NLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ 4115
Query: 1848 QLLQT---KHNAL-KDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1903
+ T K N L K S K+ ++ QW RQ+++L CL E+ L +
Sbjct: 4116 ASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNL--CLQR-EEDLQRTRDYH 4172
Query: 1904 DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIE----SKF 1959
D + E+ E + E N R AE + A++ + L +R IE K
Sbjct: 4173 DCMNVVEVFLE-KFTTEWDNLARSDAESTAVH--LEALKKLALALQERKYAIEDLKDQKQ 4229
Query: 1960 AQFRRLNFAQIHTVREETMMVMTEDMPLE--ISYVPSTYLTEITHVSQALLEVEQLLNAP 2017
LN V+E+T + LE I +T + ++ ++L+
Sbjct: 4230 KMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWA 4289
Query: 2018 DLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKK---TAALQSATPV-------ER 2067
+ + + KQ ++ L + +K+ + ++ A V ER
Sbjct: 4290 EEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNER 4349
Query: 2068 VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ 2127
+Q+ALS ++ + R+ ++++ + +F + Q ++ +Q RK
Sbjct: 4350 QVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQF---LMAVFQATSQIQQHERKIM 4406
Query: 2128 IPENW-----EHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLG 2182
E+ + +K K Q + Q V L A G E++++ ++ + S + KL
Sbjct: 4407 FREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQ 4466
Query: 2183 SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLE-PGKEQQ 2241
L + V ++ S R + LE+ F+ D ++ WL++AD + + + +
Sbjct: 4467 ELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSE 4526
Query: 2242 LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKL----KQTNL- 2296
L +L + + ++E+ P + +L L TG +L S ++ + L KL +Q N+
Sbjct: 4527 LHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPS--LNEVDHSYLSEKLNALPRQFNVI 4584
Query: 2297 ------QWIKVSRAL-------------PEKQGEIEAQ---------------------- 2315
++ KV A+ + E+EAQ
Sbjct: 4585 VALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDG 4644
Query: 2316 -------IKDLGQLEKKLEDLEE------------QLNHLLLWLSPIRNQLEIYNQPNQE 2356
+ LG+ +L +E ++ HL+ ++ Q E ++
Sbjct: 4645 CRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLED 4704
Query: 2357 GPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE---DLSSEWKAVNRLL 2413
QE E Q + ++ + + + +E T P + KL+ L+ + +L
Sbjct: 4705 TTSAYQEHEKMCQQLERQLKSVKEEQSKVNEE---TLPAEEKLKMYHSLAGSLQDSGIVL 4761
Query: 2414 QELRAKQPDLAPGLTTIGASPTQTVTLVTQ---PVVTKETAISKLEMPSSLMLEVPALAD 2470
+ + DLAP L + + Q ++T + E S ++ + D
Sbjct: 4762 KRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSI----D 4817
Query: 2471 FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAA 2530
F + DWL + + + +L+DI E I K + + Q Q I A
Sbjct: 4818 FQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQ-----IHQEEVQSSLRIMNA 4872
Query: 2531 QNLKNKTSNQEARTIITDRIERIQNQWDE----VQEHLQNRRQQLNE----------MLK 2576
+ K K +A+ +I+ +E + E +QE L+ R+ L E + +
Sbjct: 4873 LSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQ 4932
Query: 2577 DSTQWLEAKEEAEQVLG------QARAKLESWKEGPYTVDAIQKKITETKQLAKDLR--- 2627
+ WLE +E Q+ G A L+S E T D + E L L
Sbjct: 4933 AANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLI 4992
Query: 2628 QWQTNVDVANDLALKLLRD--YSADDTRKVHMITENINASWRSIHKRVSEREAALEETHR 2685
+ D+ +A LR S D +V ++ + A W K E + +T +
Sbjct: 4993 KPTGKEDLEQKVASLELRSQRMSRDSGAQVDLL-QRCTAQWHDYQKAREEVIELMNDTEK 5051
Query: 2686 LLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHT 2745
L +F L L+ ++ E +E + + + L + +
Sbjct: 5052 KLSEFSL------------------LKTSSSHE--------AEEKLSEHKALVSVVNSFH 5085
Query: 2746 DVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKR 2805
+ L+E + ++ ++ + A L R + + +W+ LR + + LE + D+W
Sbjct: 5086 EKIVALEEKASQLEKTGNDASKAT-LSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTG 5144
Query: 2806 LHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVI-MSTLET 2864
+ +++ + D+L + + + H F EL+ ++ + M +T
Sbjct: 5145 FNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQT 5204
Query: 2865 VRIFLT-------EQPLEGLEKLYQEPRELPPEERAQNVTRLLR---KQAEEVNTEWEKL 2914
+ + E+P E + R L +E+ + +L++ K E V T+ +
Sbjct: 5205 LSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5264
Query: 2915 NLHSADWQR-------KIDETLERLQ-ELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS 2966
+ + +ID LE LQ L EAT+ + AE K + + +L
Sbjct: 5265 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSE 5324
Query: 2967 LQDHL--------------EKVKALRGEIAPLKENVSHVNDLARQLTTL 3001
L L +K+K + A +E + LA+ LTT+
Sbjct: 5325 LSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTI 5373
Score = 187 bits (475), Expect = 2e-46
Identities = 416/2217 (18%), Positives = 866/2217 (39%), Gaps = 360/2217 (16%)
Query: 413 ETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKM-- 470
E ++++ L ++ L + ++S L++ L L++Q + L D E KM
Sbjct: 6482 EQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLT-LKSQYERALQDLADLLETGQEKMAG 6540
Query: 471 EEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV--VVDESSGDHATAALEEQ 528
+++ + E++++ + +HK + LE + +L ++ V + + H T + +
Sbjct: 6541 DQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFH-TELMAQA 6599
Query: 529 LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKD 588
VL + R V L+ IL W L E+Q S L E ++ + G +
Sbjct: 6600 SAVL--------KRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSV---GLVE 6648
Query: 589 QNE--MLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLK----NKSVTQKTEAWLDN 642
+NE ++ + LK+ L + + + ++ + LL ++ + Q E WL N
Sbjct: 6649 ENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSN 6708
Query: 643 -------------FARCWD-------NLVQKLEKSTAQIS----QAVTTTQP-------- 670
+ W +L+ L+ + ++ Q+VT Q
Sbjct: 6709 TNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHL 6768
Query: 671 -------------SLTQTTVMETVTTVTTREQILVKHAQEELP-------------PPPP 704
S +++V+ T + +++ + EL P
Sbjct: 6769 NAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQ 6828
Query: 705 QKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEG--NFSDLKEKVNAI 762
+K Q+ +D + I+E+ SWI+ E V+Q E I G + +K
Sbjct: 6829 EKLHQLQMDKLPSRHA---ISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGF 6885
Query: 763 EREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE--QLNSRWIEFCQLLSERL- 819
+ + K + ++S + Q V E +D A + +N W L++E++
Sbjct: 6886 KIDINCKQLTVDFVNQSVLQISSQDV-ESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQ 6944
Query: 820 -------NWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDE 872
+W EY+NN+ Q L+ T E LK Q + ++++ LK C+D
Sbjct: 6945 LLEGLLESWSEYENNV-------QCLKTWFETQEKRLK-QQHRIGDQASVQNALKDCQDL 6996
Query: 873 VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIF 932
+ + + ++E+++ +AL + + + + ++ Q ++++ +L+ +
Sbjct: 6997 EDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTLRELGQTWANLDHMVGQLKILL 7054
Query: 933 DTLPPM--RYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS 990
++ ++ I +++ ++ LS +L E ++ ++ LQ LQ L++Q+
Sbjct: 7055 KSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQER 7114
Query: 991 GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQ 1050
L + ++ K+ ++ + +E+ RW L ++ E Q + + ++ +
Sbjct: 7115 SLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYK 7174
Query: 1051 NHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQ----LKQCRLLVSDIQTIQPSLNSVNE 1106
++ + + + + E A + +I + ++ C L+ + T++ SL ++E
Sbjct: 7175 DYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHE 7234
Query: 1107 GGQKIKNEAEPEFASRLETELKELNTQWDHMC---QQVYARKEALKGGLEKTVSLQKDLS 1163
G+++K + + AS ++++ L+ H+C Q + ++ +L+ G+ + K L
Sbjct: 7235 LGEQLKQQVDASAASAIQSDQLSLS---QHLCALEQALCKQQTSLQAGVLDYETFAKSLE 7291
Query: 1164 EMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1222
+ W+ +AEE +D + + +Q+ +EE+K + + L E +
Sbjct: 7292 ALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE-----LG 7346
Query: 1223 QAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN-EV 1281
P+ + +K+ ++ L ++ + ++ + L+ + H+ ++LEK W+ V
Sbjct: 7347 YRLPLNDKEIKR-MQNLNRHWSLISSQTTERFSKLQS-FLLQHQ--TFLEKCETWMEFLV 7402
Query: 1282 EFKLKTTENIPGGAEEISE---VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDEL--I 1336
+ + K I G + + E + + M + + I I Q L + G +D+
Sbjct: 7403 QTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEF 7462
Query: 1337 NEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTF------------ 1384
N +L +++W+ + A +R+ +++ I+ Q + +++ L
Sbjct: 7463 NLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSV 7522
Query: 1385 -IDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAA-QRVLSQIDV 1442
I Q A + D+V + Q+ S + + E + + + G EAA Q L++I
Sbjct: 7523 PIPLQQARTLFDEVQFKEKVFLRQQ-GSYILTVEAGKQLLLSADSGAEAALQAELAEI-- 7579
Query: 1443 AQKKLQDVSMKFRLFQKPANF--------EQRLQESKMILDEVKMHLPALETKSVEQEVV 1494
Q+K + SM+ +K F E+ + +S L K L ++ E +
Sbjct: 7580 -QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS--QSLPDHHEEL 7636
Query: 1495 QSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAK 1554
++ C L ++ ++ + + ++ L+ERV L+ + EL +
Sbjct: 7637 HAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQ 7696
Query: 1555 VTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRS--AVEGMPSNLDSEVAWGKA 1612
++ R+QQ+ + L ++ L EWL + ++++ +E M L K
Sbjct: 7697 LSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK------KD 7750
Query: 1613 TQKEIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLL 1671
Q+EI + + + ++GE L K K + +E KL +N W + + L
Sbjct: 7751 YQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLK 7810
Query: 1672 EYQKHMETFDQNVDHITKWIIQADTLL-----------DESEKKKPQQKE---------- 1710
E ++ D+N+ + W+ ++ L +E ++K +Q+E
Sbjct: 7811 ETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHST 7870
Query: 1711 ---DVLKRLKAELND-----IRPKVDSTRDQAANLMANRGDHCRKLVEPQI--------- 1753
VL + L+D + DS + NL + C +E ++
Sbjct: 7871 GVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLW 7930
Query: 1754 ----------------SELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEI 1797
SE F + S I T A LK+ E F + + L LE
Sbjct: 7931 QKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT-VAKEELKKFEAFQRQVHECLTQLEL-- 7987
Query: 1798 QQGVNLKEEDFNKDMNEDNEGTVKELL----QRGDNLQQRITD----------------- 1836
+N + ++ D+ ++K+++ QR DNLQ+R+T
Sbjct: 7988 ---INKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFET 8044
Query: 1837 ---------------------------ERKREEIKIKQQLLQTKHNALKDLRSQRRK--- 1866
+ K +++K QQ + HN ++ + +Q +
Sbjct: 8045 ARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIE 8104
Query: 1867 -----KALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK-- 1919
A I + + +R ++ ++ KKL LP P DE + + + EL+
Sbjct: 8105 KSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAAL 8164
Query: 1920 EELNAVRRQAEGL--SEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREET 1977
+L+ R A+ L + + +++ Q S+R L + + + +
Sbjct: 8165 SDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDL 8224
Query: 1978 MMVMTEDMPLEISYVPST---YLTEITHVSQALLE------VEQLLNAPDLCAKDFEDLF 2028
M+ +P E YL +S ++ V+ NA + D L
Sbjct: 8225 ESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALE 8284
Query: 2029 KQEESL-KNIKDSLQQSSGRIDIIHSKK--------------------TAALQSATPVER 2067
Q L K + DS Q +II SK ++++ S +E
Sbjct: 8285 SQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEH 8344
Query: 2068 VKLQEALSQLDF---------------QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIF 2112
+E S F +WE + ++ R ++++KW++F+ D+
Sbjct: 8345 KLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSI 8404
Query: 2113 NQWLTEAEQFLRKTQIPE-----NWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQ 2167
WL + E+ L + Q E + K LKELQ + R+ ++ ++N E Q
Sbjct: 8405 WAWLGDTEEELEQLQRLELSTDIQTIELQIK-KLKELQKAVDHRKAIILSINLCSPEFTQ 8463
Query: 2168 QSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD 2227
SK ++ LQ++L +N RW VC L + + L++ F + +L LE D
Sbjct: 8464 ADSK-ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENID 8522
Query: 2228 NIAS--IPLEPGKEQQ-LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQ 2284
+ +P++ + + L++ +Q+ + EL Q + L + +LV+A E
Sbjct: 8523 RRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNA----EGT 8578
Query: 2285 DKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLS 2341
D LE K K + L E+ IK+L +KL D+ L W S
Sbjct: 8579 DCLEAKEKVH-----VIGNRLKLLLKEVSRHIKEL----EKLLDVSSSQQDLSSWSS 8626
Score = 179 bits (455), Expect = 3e-44
Identities = 534/2881 (18%), Positives = 1106/2881 (38%), Gaps = 406/2881 (14%)
Query: 329 SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAH 388
+L E+ +YQ +L+ + + + + E L E E Q H+ M ++
Sbjct: 5886 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILML 5942
Query: 389 QGRVGNILQ-LGSKLIGTG-KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 446
Q + + L +L+ + E+ +Q + +L R +R+ + K+ L L
Sbjct: 5943 QDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN 6002
Query: 447 DL-----QNQKLK-------ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE 494
D Q Q L+ EL+ WL T+ P P D++ Q+ + +
Sbjct: 6003 DQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP--MDMEAQLMDCQNMLV 6060
Query: 495 DLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDIL 554
++EQ+ V ++ L+ V +E+ A +++ + L + L+ L
Sbjct: 6061 EIEQKVVALSELS----VHNENLLLEGKAHTKDEAEQLAGKLRR-----------LKGSL 6105
Query: 555 LKWQR-LTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEML------------SSLQKLAV 601
L+ QR L ++Q EKE++ + T E L SSLQ+
Sbjct: 6106 LELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE 6165
Query: 602 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT------------------QKTEAWLDNF 643
L+ +L ++K + + S +++L + +K+ A D
Sbjct: 6166 LEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE-DQM 6224
Query: 644 ARCWDNLVQK-------LEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILV---- 692
W++L Q+ L+ Q + V ++P+ + V V T+++ V
Sbjct: 6225 RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL 6284
Query: 693 ---KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL--------QSP 741
A EE+ KRQ + ++L ++ +W+ E L +
Sbjct: 6285 DGLNQAFEEVSSQSGGAKRQ---SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6341
Query: 742 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 801
E +F +E D+KE +++ K + +QA E N V D++
Sbjct: 6342 ETCLFNQEILAKDIKEMSEEMDKNK----------NLFSQAFPENGDNRDVIEDTLGCLL 6391
Query: 802 EQLN---SRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN-WLKIQPTTPS 857
+L+ S + C + ERL I+ F N L+ L T+ A+N ++ +Q
Sbjct: 6392 GRLSLLDSVVNQRCHQMKERLQ------QILNFQNDLKVL--FTSLADNKYIILQKLANV 6443
Query: 858 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV 917
+ Q++ + + L I LK + L+ + L + + ++
Sbjct: 6444 FEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSK----LQDMYDEL 6499
Query: 918 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 977
+ +R L + +Y+ + + ++ + K++ D +I+ E
Sbjct: 6500 MMIIGSRRSGLNQ--NLTLKSQYERALQDLADLLETGQEKMA------GDQKIIVSSKEE 6551
Query: 978 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1037
+Q L +E GL + + +K S +K E+ + +S +++
Sbjct: 6552 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ----ASAVLKRAH 6607
Query: 1038 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG----DSEILKKQLKQCRLLVSD 1093
K ++ + + +H+ ++ ++ ++ P++G + + L ++ + L S
Sbjct: 6608 KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSS 6667
Query: 1094 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLE 1153
+ QP L V + G+++ S LE++L +L W ++ L+ L+
Sbjct: 6668 LNEYQPKLYQVLDDGKRLLISIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILK 6724
Query: 1154 KTVSLQKDLSEMHEWMTQAEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVK 1211
Q + +++ W+ A++ E+ + P EL+ + + E +++ +A+
Sbjct: 6725 HWTRYQSESADLIHWLQSAKDRLEFWTQQ-SVTVPQELEMVRDHLNAFLEFSKEVDAQSS 6783
Query: 1212 LLTE--SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLS 1269
L + S + + + V L+ EL + + + L T + + L ++
Sbjct: 6784 LKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRH 6843
Query: 1270 YLEKANKWLNEVEFKL-KTTENIPG--GAEEISEVLDSLE------NLMRHSEDNPNQ-- 1318
+ + W++ +E + K +NI G + I E L + N + + D NQ
Sbjct: 6844 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 6903
Query: 1319 IRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLI 1378
++I +Q + E+L N W+ L + +LLE ++S E E ++ +
Sbjct: 6904 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 6963
Query: 1379 QESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV 1436
+ +K+L I D+ ++ Q ++ + + E +E+++++
Sbjct: 6964 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNG--------- 7014
Query: 1437 LSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRLQESKMILD---------------- 1475
+ + Q K +DVS L Q AN + + + K++L
Sbjct: 7015 ---LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKI 7071
Query: 1476 -----EVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1530
E + L + E VQ Q+++ NL L + + ++ Q++++
Sbjct: 7072 NSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 7131
Query: 1531 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR---KEMNVLTEWLAATD 1587
+ L + + + +N L ++ E+ Q + L+L ++ + K+ +
Sbjct: 7132 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 7191
Query: 1588 MELTKRSAVEGMPSNLDSEVA-WGKATQ---KEIEKQKVHLKSITEVGEALKTVLGKK-- 1641
EL K + + + D EVA W + K + K L + E+GE LK +
Sbjct: 7192 NELLKAATNKDIA---DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAA 7248
Query: 1642 ETLVEDKLSLLNSNWIAVTSRAEEWLNL---LLEYQKHMETFDQNVDHITKWIIQADTLL 1698
+ D+LSL + ++ +L +L+Y ETF ++++ + WI++A+ +L
Sbjct: 7249 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY----ETFAKSLEALEAWIVEAEEIL 7304
Query: 1699 D------ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 1752
S+ Q++ + LK + + + P +D + L N + R
Sbjct: 7305 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKR------ 7358
Query: 1753 ISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNK-- 1810
+ LN ++ IS + T + S L Q + ++K +E +Q L E
Sbjct: 7359 MQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQ 7417
Query: 1811 ---DMNEDNEGTVKELLQRGDNLQQRITDERK---------REEIKIKQQLLQTKHNALK 1858
+ +E E+ R L I D ++ R+E +K LL + +
Sbjct: 7418 HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI 7477
Query: 1859 DLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE----KKLASLPEPR-------DERK 1907
QRR QW +Y+ A+ L K L ++ L S+P P DE +
Sbjct: 7478 RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ 7537
Query: 1908 IKEIDRELQKKKEELNAVRRQAEGLSED-GAAMAVEPTQIQLSKRWREIESKFA-QFRRL 1965
KE Q+ L + LS D GA A++ ++ ++W+ + Q ++L
Sbjct: 7538 FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL 7597
Query: 1966 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 2025
F ++ E I+ T +SQ+L + + L+A + K+ E
Sbjct: 7598 AF----------LLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELE 7647
Query: 2026 DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN 2085
+ ++ + D L Q S D + +A SA + L E + L QWE++
Sbjct: 7648 N------AVGSWTDDLTQLSLLKDTL-----SAYISADDISI--LNERVELLQRQWEELC 7694
Query: 2086 KMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ---IPENWEHAKYKWYLK 2142
R+ + + +W F K +WLT+ E + + I E E K K
Sbjct: 7695 HQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK-----K 7749
Query: 2143 ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRL 2202
+ Q+ I Q L GE + + S ++ AS ++ KLG +N RWQ + ++ R K+L
Sbjct: 7750 DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKL 7809
Query: 2203 EEQKNILSEFQRDLNEFVLWLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ 2260
+E + + ++++ WL ++ + P+ + ++++ KL + + L ++
Sbjct: 7810 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 7869
Query: 2261 -GILKQLNETGGPVLV---SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2316
G+ LN VL+ A + E D ++ + + +W + E++ +IE
Sbjct: 7870 TGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE--- 7924
Query: 2317 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2376
+ +L +K D + WL + F I AK+
Sbjct: 7925 -ETWRLWQKFLDDYSRFED---WLK----------SSERTAAFPSSSGVIYTVAKE---- 7966
Query: 2377 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPT 2435
E + +R++ + ++ + +N+ + L R + D A L +
Sbjct: 7967 -----------ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 8015
Query: 2436 QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2495
Q + + V T+I + L + +F A + WL+ +D ++ +
Sbjct: 8016 QRWDNLQKRV----TSILR-----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIE 8064
Query: 2496 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2555
D+ I + KA Q++ ++E++I + L K+ +A II + ++ ++
Sbjct: 8065 HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRR 8123
Query: 2556 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2615
EV ++ ++L + + + E E A + L ++ + Q
Sbjct: 8124 YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 8183
Query: 2616 ITETKQLAKDLR-----------------QWQTNVDVANDLALKLLR-----DYSADDTR 2653
+ LA+ LR +W + D++ DL + R D D +
Sbjct: 8184 SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDK 8243
Query: 2654 KVH----------MITENINASWRSIH---KRVSEREAALEETHRLLQQFPLDLEKFLAW 2700
+ MI E+ A + K S +ALE R L + LD +F
Sbjct: 8244 DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGK-ALDDSRF--- 8299
Query: 2701 LTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILR 2760
+ + T N+++ T L+ S K + L GE + D L+ ++
Sbjct: 8300 --QIQQTENIIRSKTPTGPELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEE 8351
Query: 2761 SLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLK 2820
SL G + + + + +W L+ ++L+ ++ + +W++ + L + WL
Sbjct: 8352 SLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDT 8411
Query: 2821 DDELSR--QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLE 2878
++EL + + + D ++ Q + ++ + ++ +I+S F E
Sbjct: 8412 EEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE--- 8468
Query: 2879 KLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEA 2938
+R L+ + ++N W+++ +W+ + + L + Q E
Sbjct: 8469 ------------------SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEM 8510
Query: 2939 TDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQ 2997
+ L L L + K P+ +L + LQDH +++ ++ E+ + V+ + D++ Q
Sbjct: 8511 SHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQ 8570
Query: 2998 L 2998
L
Sbjct: 8571 L 8571
Score = 179 bits (453), Expect = 6e-44
Identities = 534/2830 (18%), Positives = 1094/2830 (38%), Gaps = 372/2830 (13%)
Query: 378 HEGYMMDLTAHQGRVGNILQLGSKLIGTGKL-SEDEETEVQEQMNLLNSRWECLRVASME 436
H+ ++++L Q +G + Q ++ G + EE + +++ + R CL +
Sbjct: 5183 HDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR--CLNMQEKV 5240
Query: 437 KQSNLHRVLMDLQNQKLKE-----LNDWLTKTEERTRK--MEEEPLGPDLEDLKRQVQQH 489
K +N V +L+++++ E + W+ +T+E +E + +L+ L + H
Sbjct: 5241 K-TNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNH 5299
Query: 490 KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 549
+ E + +EQ + L ++ E S A AL+ +++ D+ + + E
Sbjct: 5300 RQNIEKMAEEQ-KEKYLGLYTILPSELSLQLAEVALDLKIR---DQIQDKIKEVEQSKAT 5355
Query: 550 LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK- 608
Q++ + Q+L ++ L K D V + T E+ KL L A ++K
Sbjct: 5356 SQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKF 5415
Query: 609 ----------KKQSMGKLYSLKQDLLSTLKNK-SVTQKTEAWLDNFARCWDNLVQKLEK- 656
+ +GKL L Q + +N+ S + + L+ + + +++ +EK
Sbjct: 5416 LEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKA 5475
Query: 657 -----------STAQISQAVTTTQPSLTQ-----------TTVMETVTTVTTREQILVKH 694
S +Q+ + Q L + T ++ +T+V E++ +
Sbjct: 5476 KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQV 5535
Query: 695 AQ-----EELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKE 749
A+ EEL + + + ++ K+ + ++ +L + + +++A L SPE +
Sbjct: 5536 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5595
Query: 750 GNFSDLKEKVNAIE--REKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 807
S + ++ +E + K + + Q A R + +V + A +++ + +L
Sbjct: 5596 EQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA-ALRLQEEASRLQHT 5654
Query: 808 WIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLK 867
I+ C ++ + ++Y+ + +++ L+Q+ A ++ +P S +++Q+
Sbjct: 5655 AIQQCNIMQAAV--VQYEQ----YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQIS 5708
Query: 868 ICKDEVNRLSGLQPQIERL--KIQSIALKEK--------------GQGPMFLDADFVAFT 911
++ ++ G Q QI L K + + +K K +G LD + +
Sbjct: 5709 RHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTP 5768
Query: 912 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 971
+ V R L L P+ + + + S ++ TD +
Sbjct: 5769 SAHPSVVMMTAGRCHTL------LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV- 5821
Query: 972 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQ 1031
Q + QAL + + + + ST+ + + E S ++ +++ W+ L +
Sbjct: 5822 NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT--AKLGDLQRSWETLKNV 5879
Query: 1032 LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLV 1091
+ E + L E + + +K Q+ +Q++ M +++ L E P G S + Q+ + + L+
Sbjct: 5880 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSES-PEPGRSP--ESQMAEHQALM 5936
Query: 1092 SDIQTIQPSLNSVNEG-GQKIKNE---AEPEFASRLETELKELNTQWDHMCQQVYARKEA 1147
+I +Q +N + +++ +E A+P L++ L L + + + +++
Sbjct: 5937 DEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQL 5996
Query: 1148 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1207
L+ L + Q+ + + +A+E + T L A+ K + Q
Sbjct: 5997 LEEKLNDQLEEQRQEQALQRYRCEADEL---DSWLLSTKATLDTALSPPKEPMDMEAQLM 6053
Query: 1208 AKVKLLTESVNSVIAQAP-PVAQEALKKELETLTTNYQWLCTRLNGKCKTLE----EVWA 1262
+L E V+A + V E L E + T + +L GK + L+ E+
Sbjct: 6054 DCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDE---AEQLAGKLRRLKGSLLELQR 6110
Query: 1263 CWHELLSYLEKANKWLNEVEFKLKTTENIPGGAE---------------------EISEV 1301
H+ ++ + E + L T++ PG E E+ +
Sbjct: 6111 ALHDKQLNMQGTAQEKEESDVDLTATQS-PGVQEWLAQARTTWTQQRQSSLQQQKELEQE 6169
Query: 1302 LDSLENLMRHSEDNPNQIRI---LAQTLTDGGVMDELINEEL----------ETFNSRWR 1348
L ++L+R +I I A+T D G +++++EL + +W
Sbjct: 6170 LAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWE 6229
Query: 1349 ELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQK 1408
LH+E +QKLL+ ++ QE Q + ++ L+ K D Q+
Sbjct: 6230 SLHQEFSTKQKLLQNVLEQEQE--------QVLYSRPNRLLSGVPLYKGDVP--TQDKSA 6279
Query: 1409 IQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQ 1468
+ S L + EE+ + G + I + QK VS + E+RL
Sbjct: 6280 VTSLLDGLNQAFEEVSSQSGGAKR-----QSIHLEQKLYDGVSATSTWLD---DVEERLF 6331
Query: 1469 ESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK 1528
+ +L E ET QE+ L K + E+ E++ Q
Sbjct: 6332 VATALLPE------ETETCLFNQEI----------LAKDIKEMSEEMDKNKNLFSQAF-P 6374
Query: 1529 KQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDM 1588
+ +N +++ + L + L + V +R Q+++ L+ + ++ VL LA
Sbjct: 6375 ENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKY 6434
Query: 1589 ELTKRSA--VEGMPSNLDSEVAWGKATQKEIEKQKVHLK---SITEVGEALKTVLGKKET 1643
+ ++ A E + + + KE + + LK +V + L K +
Sbjct: 6435 IILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQD 6494
Query: 1644 LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK 1703
+ ++ + ++ S S + L L +Y++ ++ AD L EK
Sbjct: 6495 MYDELMMIIGSR----RSGLNQNLTLKSQYERALQDL-------------ADLLETGQEK 6537
Query: 1704 KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI-------SEL 1756
QK ++ K E+ + K + M RK++ + +EL
Sbjct: 6538 MAGDQK--IIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTEL 6595
Query: 1757 NHRFAAISHRIKTGKASIPLK-------ELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFN 1809
+ +A+ R K + L+ L++ ++ + LE +E+ I V L EE N
Sbjct: 6596 MAQASAVLKR--AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI-PSVGLVEE--N 6650
Query: 1810 KDMNEDNEGTVKELLQRGDNLQQR---ITDERKREEIKIKQQLLQTKHNALKDLRSQRRK 1866
+D D + L + Q + + D+ KR I I L+++ N L +
Sbjct: 6651 EDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTN 6710
Query: 1867 KALEISHQ-------WYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK 1919
K + H+ W +Y+ ++ DL+ L + +L + + + +EL+ +
Sbjct: 6711 KMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ-----QSVTVPQELEMVR 6765
Query: 1920 EELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMM 1979
+ LNA ++ + + + + S Q RL T+R E
Sbjct: 6766 DHLNAFLEFSKEVDAQSSLKS-------------SVLSTGNQLLRLKKVDTATLRSELSR 6812
Query: 1980 VMTEDMPLEISYVPSTYLTEITHVSQ--------ALLEVEQLLNAPDLCAKDFEDLFKQE 2031
+ ++ L ++ +P+ + E H Q A+ EV ++ + + ED K
Sbjct: 6813 IDSQWTDL-LTNIPA--VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNS 6869
Query: 2032 ESLKNIKDSLQQSSG-RIDIIHSKKT------AALQ-SATPVE-----RVKLQEALSQLD 2078
K I + LQ+ G +IDI + T + LQ S+ VE + E L ++
Sbjct: 6870 IGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMN 6929
Query: 2079 FQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYK 2138
W+ + + ++ + +E W + +++ W E+ L+ Q + A +
Sbjct: 6930 KSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLK--QQHRIGDQASVQ 6987
Query: 2139 WYLK---ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQL 2195
LK +L+D I ++ V + G +IQ + +SI+ L L W + +
Sbjct: 6988 NALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMV 7047
Query: 2196 SDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVE 2254
K L+ + S + ++ +L EA +++ L G + ++ +++ ++ L +
Sbjct: 7048 GQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQD 7107
Query: 2255 ELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEA 2314
+L ++ L++ +L P + L N LK+ N++W L E+ E
Sbjct: 7108 DLEKQERSLQKFGSITNQLLKEC--HPPVTETLTNTLKEVNMRW----NNLLEEIAEQLQ 7161
Query: 2315 QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP-FDVQETEIAVQAKQP 2373
K L QL ++ +D +Q S ++ Q + N+ + D+ + E+A +
Sbjct: 7162 SSKALLQLWQRYKDYSKQC------ASTVQQQEDRTNELLKAATNKDIADDEVATWIQ-- 7213
Query: 2374 DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 2433
D ++L KG K+ L +L + K Q++ A AS
Sbjct: 7214 DCNDLL-KGLGTVKDSLFF------LHELGEQLK------QQVDAS-----------AAS 7249
Query: 2434 PTQTVTL-VTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQ 2492
Q+ L ++Q + E A+ K + +SL V F ++ L W+ +++++ Q
Sbjct: 7250 AIQSDQLSLSQHLCALEQALCKQQ--TSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQ 7307
Query: 2493 RVM-VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2551
DL I E + + K M P L+ L L +++E + R++
Sbjct: 7308 DPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL--PLNDKEIK-----RMQ 7360
Query: 2552 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2611
+ W + R +L L +LE E + L Q KL G Y
Sbjct: 7361 NLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLL 7420
Query: 2612 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2671
Q++ E Q RQ + + + +LL DD + ++ ++ W+ + +
Sbjct: 7421 EQQRAHELFQAEMFSRQQILHSIIID--GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIR 7478
Query: 2672 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVLQDATRKERLLEDSKGV 2727
R +R ++ R Q++ EK WL E + + ++ R L D
Sbjct: 7479 RAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQF 7538
Query: 2728 KELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRK 2787
KE K + QG Y E +++L S + +A LQ L + KW
Sbjct: 7539 KE--KVFLRQQGS-------YILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKWKSASM 7588
Query: 2788 KSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAF 2847
+ + L W++ + + L L+ +LS+ P ++H
Sbjct: 7589 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP--------DHHEELHAEQ 7640
Query: 2848 KRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEV 2907
R + + V T + ++ L + L A +++ +L ++ E +
Sbjct: 7641 MRCKELENAVGSWTDDLTQLSLLKDTLSAYIS-------------ADDIS-ILNERVELL 7686
Query: 2908 NTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSL 2967
+WE+L + +++I E L E EL L Q E GD+LI+ +
Sbjct: 7687 QRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQNGDILIEEM 7743
Query: 2968 QDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDLNTRWKLLQVA 3026
+ L+ K + EIA +EN + + +L + + L +N RW+ L
Sbjct: 7744 IEKLK--KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL 7801
Query: 3027 VEDRVRQLHE 3036
+ RV++L E
Sbjct: 7802 IAARVKKLKE 7811
Score = 178 bits (452), Expect = 8e-44
Identities = 374/2047 (18%), Positives = 795/2047 (38%), Gaps = 255/2047 (12%)
Query: 339 RYQTALEEVLSWLLSAEDTL----QAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 394
RYQ+ +++ WL SA+D L Q + ++E+V+D + + ++ A +
Sbjct: 6728 RYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSS 6787
Query: 395 ILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDL--QNQK 452
+L G++L+ +L + + ++ +++ ++S+W L Q LH++ MD
Sbjct: 6788 VLSTGNQLL---RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA 6844
Query: 453 LKELNDWLTKTEERTRKMEEEPLGP-DLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 511
+ E+ W++ E +K E+ + + +Q++K + D+ +Q+ V+ + V+
Sbjct: 6845 ISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVL 6904
Query: 512 VV---DESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 568
+ D S EQL + W + ++ LL+ +L W
Sbjct: 6905 QISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLK 6964
Query: 569 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLK 628
W +E + + H G DQ + ++L+ L+ ++ K++ + K+ +Q+ L+ ++
Sbjct: 6965 TWFETQEKRLKQQHRIG--DQASVQNALKDCQDLEDLIKAKEKEVEKI---EQNGLALIQ 7019
Query: 629 NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 688
NK +S V +T L QT + + +
Sbjct: 7020 NKK---------------------------EDVSSIVMSTLRELGQTWA--NLDHMVGQL 7050
Query: 689 QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRK 748
+IL+K ++ ++ D +++ + E ++R + S E A+ +
Sbjct: 7051 KILLKSVLDQW------SSHKVAFD-----KINSYLMEARYSLSRFRLLTGSLE-AVQVQ 7098
Query: 749 EGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE--GVNADSIKQASEQLNS 806
N +L++ + ER +KF ++ Q++ E +++ +++N
Sbjct: 7099 VDNLQNLQDDLEKQERS-LQKFG----------SITNQLLKECHPPVTETLTNTLKEVNM 7147
Query: 807 RWIEFCQLLSERLN--------WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE 858
RW + ++E+L W Y++ + +QQ E T LK
Sbjct: 7148 RWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL---LKAATNKDIA 7204
Query: 859 PTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEK--GQGPMFLDADFVAFTNHFKQ 916
+ + ++ C D + L ++ + L LK++ + +D ++ + H
Sbjct: 7205 DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCA 7264
Query: 917 VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLS-VTDYEIMEQRL 975
+ + ++ LQ L + +++ A+ W+ ++E L S +D +++R+
Sbjct: 7265 LEQALCKQQTSLQA--GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERM 7322
Query: 976 GELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEH 1035
EL+ L L+ E+ + P ++ K + + W +SSQ E
Sbjct: 7323 EELKGQMLKFSSMAPDLDRLN----ELGYRLP--LNDKEIKRMQNLNRHWSLISSQTTER 7376
Query: 1036 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1095
KL+ + + + +T +++ + + L E G+ + L +Q + L +++
Sbjct: 7377 FSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMF 7434
Query: 1096 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1155
+ Q L+S+ GQ++ + + + +L L+ QW + ++ R+ + + +
Sbjct: 7435 SRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQW 7494
Query: 1156 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKA---VEEMKRAKEEAQQKEAKVKL 1212
++ ++ +W+ E YL P LQ+A +E++ ++ +++ L
Sbjct: 7495 QRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYIL 7552
Query: 1213 LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLE 1272
E+ ++ A A+ AL+ EL + ++ RL + K L + W + +
Sbjct: 7553 TVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIA 7612
Query: 1273 KANKWLNEVEFKLKTTENIPGGAEEISEV---LDSLENLMRHSEDNPNQIRILAQTLTDG 1329
+ + L FK K ++++P EE+ LEN + D+ Q+ +L TL+
Sbjct: 7613 DSLEKLRT--FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAY 7670
Query: 1330 GVMDEL--INEELETFNSRWREL-HEEAVRRQKLLEQSIQSAQETEKSLHL--------- 1377
D++ +NE +E +W EL H+ ++RRQ++ E+ + A +EK+ L
Sbjct: 7671 ISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMES 7730
Query: 1378 ---------IQESLTFIDKQLAAYIA----DKVDAAQMPQEAQKIQSDLTSHEISLEEMK 1424
I+E + + K IA +K+ QM + K SHE E++
Sbjct: 7731 KVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAK-----ASHESKASEIE 7785
Query: 1425 -KHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPA 1483
K + + Q +L I KKL++ + + K + + L ++ L
Sbjct: 7786 YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDK------NMSSLRTWLAHIESELAK 7839
Query: 1484 -LETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT----ENPKELD 1538
+ S E +Q +LN L + + + + V V+ ++ +
Sbjct: 7840 PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQ 7899
Query: 1539 ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEG 1598
+ L + + A ER+ ++E+ +L +K + + +WL +++ S+
Sbjct: 7900 QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGV 7959
Query: 1599 MPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLL------ 1652
+ + E+ +A Q+++ + L+ I + L +E + SL
Sbjct: 7960 IYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-----RENRTDSACSLKQMVHEG 8014
Query: 1653 NSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDV 1712
N W + R L L + E F+ D I W+ + D L E +
Sbjct: 8015 NQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAK 8074
Query: 1713 LKRLKAELNDI---RPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT 1769
+K+LKA +I K++ Q L+ ++E ++ EL + R++
Sbjct: 8075 IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVER 8134
Query: 1770 GKASI---PLKELEQFNSDIQKLLEPLEA---------------EIQQGVNLK------- 1804
+ PL + E SD + LE A Q NL
Sbjct: 8135 YHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 8194
Query: 1805 ------------------EEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIK 1846
E D + D++ D E + L D Q D R + +
Sbjct: 8195 RSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLS 8254
Query: 1847 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPE----- 1901
++ A L K S + Q L K LDD ++
Sbjct: 8255 DVMIPESPEAYVKLTENAIKNT---SGDHSALESQIRQLGKALDDSRFQIQQTENIIRSK 8311
Query: 1902 ----PRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMA----VEPTQIQLS---K 1950
P + K + L + +++V+R L E+ ++ + T+ Q +
Sbjct: 8312 TPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVID 8371
Query: 1951 RWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEV 2010
RW ++++ A + L Q + D+ +++ T E+ + + LE+
Sbjct: 8372 RWELLQAQ-ALSKELRMKQ----NLQKWQQFNSDLNSIWAWLGDTE-EELEQLQR--LEL 8423
Query: 2011 EQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 2070
+ +L K ++L K + K I S+ S SK++ L
Sbjct: 8424 STDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESR-----------DL 8472
Query: 2071 QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ--- 2127
Q+ LSQ++ +W++V + ++ +G ++ + + FH ++ + L E R+
Sbjct: 8473 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH---EMSHGLLLMLENIDRRKNEIV 8529
Query: 2128 -IPENWEHAKYKWYLKELQD---GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGS 2183
I N + + + K+L + + Q V +L +++ + TD +EK+
Sbjct: 8530 PIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHV 8589
Query: 2184 LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLK 2243
+ R + + K++S K LE+ ++ S Q+DL+ + +E D S+ G+ +
Sbjct: 8590 IGNRLKLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS-ADELDTSGSVSPTSGRSTPNR 8647
Query: 2244 EKLEQVK 2250
+K + K
Sbjct: 8648 QKTPRGK 8654
Score = 167 bits (423), Expect = 2e-40
Identities = 526/3006 (17%), Positives = 1150/3006 (38%), Gaps = 446/3006 (14%)
Query: 346 EVLSWLLSAEDTLQAQGEISNDVE--VVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLI 403
E+ +L A+ LQ +++E + ++ + ++ L + Q V I++
Sbjct: 4070 ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK----- 4124
Query: 404 GTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKT 463
KL++ EE+ +++N LN +W + +QSN + + Q+ ++ +D +
Sbjct: 4125 -VNKLTKKEESPEHKEINHLNDQW-----LDLCRQSNNLCLQREEDLQRTRDYHDCMNVV 4178
Query: 464 E----------ERTRKMEEEPLGPDLEDLKR---QVQQHKVLQEDLE---QEQVRVNSLT 507
E + + + E LE LK+ +Q+ K EDL+ Q+ + +L
Sbjct: 4179 EVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLD 4238
Query: 508 HMVVVVDESSG-DHATAALE--------------EQLKVLGDRWANICRWTEDRWV---- 548
+V +++S + LE E+L V+ R+ + W E++
Sbjct: 4239 DKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAE 4298
Query: 549 -------------LLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 595
LL D L L +Q L + + + + + + + + LS
Sbjct: 4299 ALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSD 4358
Query: 596 LQKLAVLKADLE-KKKQSMGKLYSLK-QDLLSTLKNKSVTQKTEAWL---DNFARCWDNL 650
Q +DL ++++ + K S K Q L++ + S Q+ E + ++ D+
Sbjct: 4359 AQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD- 4417
Query: 651 VQKLEKSTAQISQAVTTTQPSLTQTTVM--ETVTTVTTREQILVKHAQEELPP------- 701
V K K+ ++ T Q +T E + VT +E+ V +EL
Sbjct: 4418 VSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQ 4477
Query: 702 PPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNA 761
+ +++ + RK D + W+ +++ ++ PE + + K
Sbjct: 4478 KCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD-IVTFPEINLMNESSELHTQLAKYQN 4536
Query: 762 IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNW 821
I + E L R+ Q ++ + N SE+LN+ +F +++ +
Sbjct: 4537 ILEQSPEYENLLLTLQRTGQTILPSL-----NEVDHSYLSEKLNALPRQFNVIVALAKDK 4591
Query: 822 LEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE-PT--AIKSQLKI---CKDEVNR 875
I + L ++TT + + L+ Q S+ PT A++ L + C+ ++
Sbjct: 4592 FYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDE 4651
Query: 876 LSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTL 935
++GL ++ L + + GQ P D T + + + E+ + + DT
Sbjct: 4652 VAGLGEAVDELNQKKEGFRSTGQ-PWQPDKMLHLVTLYHRLK----RQTEQRVSLLEDTT 4706
Query: 936 PPMRYQETMSAIRTWVQQSETKLSI---PQLSVTDYEI-MEQRLGELQALQSSLQEQQSG 991
+ E M QQ E +L Q V + + E++L +L SLQ+
Sbjct: 4707 SAYQEHEKMC------QQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIV 4760
Query: 992 LYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQN 1051
L ++ +++++ K + + + +G K L+S + E + E +M + Q
Sbjct: 4761 LKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQT 4820
Query: 1052 HIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 1111
+ W+ V L + + +++++++ ++ ++Q+ +N+++ ++
Sbjct: 4821 EMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEK 4880
Query: 1112 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1171
+A+ ++ LE L EL+ + + + R+ L + + ++W+
Sbjct: 4881 FTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED 4940
Query: 1172 AEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1229
A+E + + ++ +E K+ E +++ ++ L +++ +I P +
Sbjct: 4941 AQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIK---PTGK 4997
Query: 1230 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE-----FK 1284
E L++++ +L Q + + L+ A WH+ E+ + +N+ E F
Sbjct: 4998 EDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFS 5057
Query: 1285 LKTTENIPGGAEEISE------VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINE 1338
L T + E++SE V++S + E+ +Q+ T ++
Sbjct: 5058 LLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLE-----KTGNDASKATLSR 5112
Query: 1339 ELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVD 1398
+ T RW L A ++K+LE ++ + E + + +L A+K
Sbjct: 5113 SMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKAS 5172
Query: 1399 AAQMP-------------QEAQKIQSDLTSHEIS-LEEMKKHNQGKEAAQRVLSQIDVAQ 1444
A++ ++ Q L +S L++ G+E ++ +I Q
Sbjct: 5173 KAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPP--LMQEITAMQ 5230
Query: 1445 KKLQDVSMKFRLFQKPANFEQRLQESKMI----------LDEVKMHL--PALETKSVEQE 1492
+ ++ K + K +Q L++ +M+ + E K +L P +E
Sbjct: 5231 DRCLNMQEKVKTNGKLV--KQELKDREMVETQINSVKCWVQETKEYLGNPTIE------- 5281
Query: 1493 VVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHY---N 1549
+ +QL L + + +E + + ++ T P EL ++ + L +
Sbjct: 5282 -IDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRD 5340
Query: 1550 ELGAKVTERKQQLEKCLKLSRKMRKEMN----VLTEWLAATDMELTKRSAVEGMPSNLDS 1605
++ K+ E +Q +LSR+++K +LT+ A TD + ++ + + LD
Sbjct: 5341 QIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDG 5400
Query: 1606 EVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1665
K +E K + + G+ LGK KL+ L+ I +AE
Sbjct: 5401 ------CNSKLMELDAAVQKFLEQNGQ-----LGKPLAKKIGKLTELHQQTIR---QAEN 5446
Query: 1666 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE--KKKPQQKEDVL--KRLKAELN 1721
L+ L + H+E +++ ++ I KWI +A L + Q +E + + L E
Sbjct: 5447 RLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESK 5506
Query: 1722 DIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKEL 1779
+I ++++ ++ L + +C + + Q++EL + IK ++ K++
Sbjct: 5507 EIDSELEAMTEKLQYLTSV---YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDM 5563
Query: 1780 EQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERK 1839
++F ++++KL LE Q L + + ++ + LL ++L+ ++
Sbjct: 5564 KKFEAELKKLQAALE---QAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV----- 5615
Query: 1840 REEIKIKQQLLQTKHNALKDL-----RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1894
+ +++ Q L+ + + L + +++A + H Q + + E+
Sbjct: 5616 -QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQ 5674
Query: 1895 KLASLPEPRDERKIKEIDRELQKKKEELNAVRR-QAEGLSEDGAAMAVEPTQIQLSKRWR 1953
++ L ++ I+ RE++ K + ++ QA+ + A ++ Q Q++
Sbjct: 5675 EMKHL-----QQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASL-- 5727
Query: 1954 EIESKFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEI--------THVS 2004
+ K + + + TV E E + TED+ E+ PS + + + T +S
Sbjct: 5728 NSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLS 5787
Query: 2005 QALLE-----VEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDI----IHSKK 2055
E +++P C ++I S+ R+ IH
Sbjct: 5788 PVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPST 5847
Query: 2056 TAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQW 2115
+A+ + P L L WE + + ++Q ++E+ +++ ++ +
Sbjct: 5848 SASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTK 5907
Query: 2116 LTEAEQFLRKTQIP------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2169
+ E L ++ P + EH + LQD I + Q ++ EE++ +S
Sbjct: 5908 MEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQ------SSLAEELVSES 5961
Query: 2170 SKTDAS---ILQEKLGSLNLRWQEVCKQLSDRKKRLEE----------QKNILSEFQRDL 2216
+ D + LQ L L R + + S +++ LEE Q+ L ++ +
Sbjct: 5962 CEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEA 6021
Query: 2217 NEFVLWLEEADNIASIPLEPGKE-QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV 2275
+E WL L P KE ++ +L + ++ E+ + L +L+ +L+
Sbjct: 6022 DELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLL 6081
Query: 2276 SAPI-SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLN 2334
+ +E ++L KL++ +++ RAL +KQ ++ ++ + E ++ Q
Sbjct: 6082 EGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE--KEESDVDLTATQSP 6139
Query: 2335 HLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLY-------- 2386
+ WL+ R + Q Q +E E + ++ + + S+G+ +
Sbjct: 6140 GVQEWLAQART---TWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAET 6196
Query: 2387 ----KEKP---------------ATQPVKRKLEDLSSEWKAVNRLLQELRAKQPD----- 2422
EKP A ++ K E L E+ +LLQ + ++ +
Sbjct: 6197 SGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYS 6256
Query: 2423 ----LAPGLTTI-GASPTQTVTLVTQPVVTKETAISKLEMPS------SLMLEVPALADF 2471
L G+ G PTQ + VT + A ++ S S+ LE
Sbjct: 6257 RPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGV 6316
Query: 2472 NRAWTELTDWLSLL-----------DQVIKSQRVMVGDLEDINEMIIKQKATMQD----- 2515
+ T L D L + + +Q ++ D+++++E + K K
Sbjct: 6317 SATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPEN 6376
Query: 2516 ------------------------LEQRRPQLEELITAAQNLKNK-----TSNQEARTII 2546
+ QR Q++E + N +N TS + + II
Sbjct: 6377 GDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYII 6436
Query: 2547 ------------TDRIERIQNQWDEVQE-------------HLQNRRQQLNEMLK----- 2576
++IE IQ D ++E LQ + + E+ K
Sbjct: 6437 LQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMY 6496
Query: 2577 ------------DSTQWLEAKEEAEQVLGQARAKLESWKE---GPYTVDAIQKKITETKQ 2621
Q L K + E+ L LE+ +E G + K+ E +Q
Sbjct: 6497 DELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE--EIQQ 6554
Query: 2622 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2681
L +++ ++ L L R + +K + A ++ KR +R LE
Sbjct: 6555 LLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELE 6614
Query: 2682 ---ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQ 2738
ET L + +L + L + + + ++++ ++RL+ + + +Q L+
Sbjct: 6615 YILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE--NEDRLI-------DRITLYQHLK 6665
Query: 2739 GEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEA 2798
+ + + + ++ +++L S+ SD L+ +L+ + W K LE
Sbjct: 6666 SSLNEYQPKLYQVLDDGKRLLISISCSD----LESQLNQLGECWLSNTNKMSKELHRLET 6721
Query: 2799 SSDQWKRLHLSLQELLVWLQLKDDEL----SRQAPIGGDFPAVQKQNDVHRAFKRELKTK 2854
W R +L+ WLQ D L + + + V+ + F +E+ +
Sbjct: 6722 ILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQ 6781
Query: 2855 EPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKL 2914
+ S L T L + ++ T LR + ++++W L
Sbjct: 6782 SSLKSSVLSTGNQLLRLKKVD---------------------TATLRSELSRIDSQWTDL 6820
Query: 2915 NLHSADWQRKIDE-TLERLQELQEATDELD-LKLRQAEVIKGSWQPVGDLLIDSLQDHLE 2972
+ Q K+ + +++L ++ + + L + + K + ++ ++L+
Sbjct: 6821 LTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQ 6880
Query: 2973 KVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED----LNTRWKLLQVAVE 3028
K K + +I + V VN Q+++ ++ + + + +N W++LQ V
Sbjct: 6881 KYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVT 6940
Query: 3029 DRVRQL 3034
++++ L
Sbjct: 6941 EKIQLL 6946
Score = 165 bits (418), Expect = 7e-40
Identities = 521/2978 (17%), Positives = 1138/2978 (38%), Gaps = 396/2978 (13%)
Query: 353 SAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL--------QLGSKLIG 404
S E+ + E+ E + D + E + L HQ + I Q+ G
Sbjct: 1251 SLEELISGSKEVQEQAEKILDTENLFEAQQL-LLHHQQKTKRISAKKRDVQQQIAQAQQG 1309
Query: 405 TGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELN-DWLTKT 463
G L + E++ L S + L S E+Q R+ + L+ + E N + + +
Sbjct: 1310 EGGLPD----RGHEELRKLESTLDGLE-RSRERQER--RIQVTLRKWERFETNKETVVRY 1362
Query: 464 EERTRKMEEEPLG-PDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESS----G 518
+T E L LE L +++Q K + E V+ +L V E+S G
Sbjct: 1363 LFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENL------VKEASEIPLG 1416
Query: 519 DHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAV 578
L++Q K + ++ + E+ ++ + KW S W++EKE +
Sbjct: 1417 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1476
Query: 579 NKIHTTGFKDQNEMLSSLQKLAVLKAD--------LEKKKQSMGKLYSLKQDLLSTLKNK 630
N + T+ +M S K+ + + + LE++ QS + + + K
Sbjct: 1477 NALETSS--SAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLT 1534
Query: 631 SVTQKTEAWLDNFARCWDNLV-------QKLEKSTAQISQAVTTTQPSL----------T 673
+ + E L A+C + + QK E++ +I Q+V+ + L T
Sbjct: 1535 QIRRYGEE-LREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSAT 1593
Query: 674 QT-----------TVMETVTTVTT------REQILVKHAQEELPPPPPQ--------KKR 708
+T +E++++ T R+ + +E Q K+R
Sbjct: 1594 ETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKER 1653
Query: 709 QITVDSEIR--KRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIERE- 765
Q +++ + +RL+ +++ +W+ R EA SPE I + + A++ E
Sbjct: 1654 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEV 1713
Query: 766 --KAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLE 823
+A + KL S ++ + + +K EQL+ RW + Q++++R+N+L+
Sbjct: 1714 VSQASFYSKLLQLKESLFSVASKD-----DVKMMKLHLEQLDERWRDLPQIINKRINFLQ 1768
Query: 824 YQNNIIAFYNQLQQLEQMTTTAENWLKI---QPTTPSEPTAIKSQLKIC--KDEVNRLSG 878
+++A + QQ +++ + W+K+ + T SE + + Q+ + KD +
Sbjct: 1769 ---SVVA---EHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVES 1822
Query: 879 LQPQIERLKIQSIALKEKGQGP--MFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLP 936
+ +++ L+ L G+ L F++ V+ R+ L + + L
Sbjct: 1823 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFL- 1881
Query: 937 PMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLS 996
+ ++S I ++Q T + ++ + +++E+ L + +L+ L +
Sbjct: 1882 --QSHASLSGILRQLRQ--TVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGIL 1937
Query: 997 TTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTL 1056
+ + K SE ++ +++ G +++ + L + + + Q+ + L
Sbjct: 1938 SKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEEL 1997
Query: 1057 KKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAE 1116
K + +++ +E + L+++L+ L ++ + + L + + ++I + +
Sbjct: 1998 LKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIA-QKD 2056
Query: 1117 PEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEY 1176
FA ++ E+ L WD + ++ + G ++ Q S + + + A
Sbjct: 2057 VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVI 2116
Query: 1177 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ---EALK 1233
+ R K ++L+ A + + AK + K+ + T ++++ + +K
Sbjct: 2117 VTRT-TIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVK 2175
Query: 1234 KELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN----EVEFKLKTTE 1289
++E+ + + +L L + W ++LS ++ W N ++ + +
Sbjct: 2176 TDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLD 2235
Query: 1290 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1349
N E + E ++N E+ +++ L + + +L E +
Sbjct: 2236 NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHA 2295
Query: 1350 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAA-----QMPQ 1404
V + L + + QS Q EK ++ I T +++ L ++ A + +
Sbjct: 2296 KEITEVAKGTLKDFTAQSTQ-VEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQK 2354
Query: 1405 EAQKIQSDLTSHEISLEEM--KKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPA- 1461
E Q QS+++S + +L + K H+ E+ R ++ + + + + K + + +
Sbjct: 2355 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2414
Query: 1462 --NFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVI 1519
+F + +QE + K ++ + +V++++L+ N+ S+S+ +S+++ V
Sbjct: 2415 EKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2474
Query: 1520 KTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVL 1579
+ G+ + + + E++T + + + KQ L+ C + L
Sbjct: 2475 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2534
Query: 1580 TEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 1639
W+ E+ +R E NL + E+ K ++ L + E+L +
Sbjct: 2535 NLWI----HEMEERFNTE----NLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQ 2586
Query: 1640 KKETLVEDK----------LSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITK 1689
+ + L E+ LL S+ + E+ + + Q+H E ++ + +
Sbjct: 2587 RGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEH-EALEEALQSMWF 2645
Query: 1690 WIIQADTLLDESEKKKPQQKEDVLKRLKAELNDI-------RPKVDSTRDQAANLMANRG 1742
W+ L +E +D L++ +++ DI K++ + + +
Sbjct: 2646 WVKAIQDRLACAE--STLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSN 2703
Query: 1743 DHCRKLVEPQISELNHRFAAIS----HRIKTGKASIP-----LKELEQFNSDIQKLLEPL 1793
+++++ Q+ L +A I H T ++ I ++ Q ++ + + +
Sbjct: 2704 KEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI 2763
Query: 1794 EAEIQQGVNLKEEDFNKD-------MNEDNEGTVKELLQRGDNLQQRITDERKREEIKIK 1846
E +Q LKE+ D ED+ + L+ + L ++ DE ++
Sbjct: 2764 EHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKD---TA 2820
Query: 1847 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1906
Q+ L+T+ N + + ++ +K EI D L LD
Sbjct: 2821 QEELKTQFNDIMTVAKEKMRKVEEI----------VKDHLMYLD---------------- 2854
Query: 1907 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1966
+ E L KEEL+ + +S D +A TQ +LSK I+S+ RL+
Sbjct: 2855 AVHEFTDWLHSAKEELH----RWSDMSGDSSA-----TQKKLSKIKELIDSREIGASRLS 2905
Query: 1967 FAQ--IHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDF 2024
+ V++ T E M E+ + + + V Q +E L++ L ++F
Sbjct: 2906 RVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEF 2965
Query: 2025 EDLFKQ-EESLKNIKDSLQQSSGRIDIIHSKKT---------------AALQSATP-VER 2067
Q E++L+ L+ + ++ ++ K T ALQ A P E
Sbjct: 2966 SGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTED 3025
Query: 2068 VKLQ-----EALSQLDFQWEKVNKMYKD--------RQGRFDRSVEKWRRFHYDIKIFNQ 2114
+K Q L KV+ + K+ +G ++ +RF + F Q
Sbjct: 3026 LKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQ 3085
Query: 2115 WLTEAEQFLRKT-QIPENWEHAKYKWYLKELQDGIGQRQTVVRTLN---ATGEEIIQQSS 2170
WL A+ K IP+N L+++Q+ + + + LN + GE + +
Sbjct: 3086 WLVNAKITTAKCFDIPQNISEVSTS--LQKIQEFLSESENGQHKLNMMLSKGELLSTLLT 3143
Query: 2171 KTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWL------- 2223
K A +Q K+ + W+ L ++ LE K + +F+ WL
Sbjct: 3144 KEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMV 3203
Query: 2224 -EEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPE 2282
E ++ + +P + ++Q+L+ LE++ +L + +QL E
Sbjct: 3204 HESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWE-----------GQA 3252
Query: 2283 EQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSP 2342
+++ Q + Q++ +S EK ++ + + Q +++L++ W++
Sbjct: 3253 ASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQD-------WMTD 3305
Query: 2343 IRNQLEIYNQP-NQEGPFDVQETEIAV-----QAKQPDVEEILSKGQH-LYKEKPATQP- 2394
+ L+ Y P + + D + ++ Q K+ ++ I+++G+ L P P
Sbjct: 3306 AIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT 3365
Query: 2395 VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK 2454
++++L+ + W ++ L +R K E A+SK
Sbjct: 3366 IQQQLQSVKDMWASL--LSAGIRCKS--------------------------QLEGALSK 3397
Query: 2455 LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQ 2514
+ + + W+ ++ + +L D M+ K K +
Sbjct: 3398 -------------WTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNE 3444
Query: 2515 DLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEV---QEHLQNRRQQL 2571
++ LE + + Q + +R IQ + E E L Q+
Sbjct: 3445 EVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEY 3504
Query: 2572 NEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQ- 2630
LK WL ++E + + + +Q E + L + +
Sbjct: 3505 QRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTRE 3564
Query: 2631 ----TNVDVANDLALKLLR-DYSADDTRKVHMITE--NINASWRSIHKRVSE-----REA 2678
+ + A D AL+ LR D+ A R T+ N+ R + ++ + + A
Sbjct: 3565 DVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTA 3624
Query: 2679 ALEETHRLLQQFPLDLEKFLA----WLTEAETTANVLQDATRKE--------RLLEDSKG 2726
++ H + + ++E+ A L E+ + + AT+ ++LE K
Sbjct: 3625 EEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKF 3684
Query: 2727 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR 2786
++E ++ ++ + + +++D Y + +N + + ++ D V++ ++L + ++
Sbjct: 3685 LEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKID-KVDTVMMGKKLKTLEVLLKDME 3743
Query: 2787 KKSLNIRSHLEASSDQWKRLHLSLQELL------VWLQLKDDELSRQAPIGGDFPAVQKQ 2840
K ++S E K L E L QLK+ + + + ++K
Sbjct: 3744 KGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKE----LTSTVRKEHMTLEKG 3799
Query: 2841 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 2900
+ + F + K I E + + P E +LY++ +L + Q
Sbjct: 3800 LHLAKEFSDKCKALTQWIAEYQEILHV-----PEEPKMELYEKKAQLSKYKSLQQTVLSH 3854
Query: 2901 RKQAEEVNTEWEKL--NLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQP 2958
+ V + E L + + KID+ Q+L + ++ E + Q
Sbjct: 3855 EPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQM 3914
Query: 2959 VGDLLIDSLQDHLEKVKALRGEIAPLKENV-SHVNDLARQLTTLGIQLSPYNLSTLEDLN 3017
GD LI DHL+ A LK+NV +H+ + + S +L
Sbjct: 3915 KGDTLIGQCADHLQ---------AKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQ 3965
Query: 3018 TRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTT 3077
V+ +D ++Q + + A Q L S Q P RA + +V ++ + Q
Sbjct: 3966 K-----HVSRQDTLQQC----QAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQAR 4016
Query: 3078 CWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKAL 3115
+ +L S+ DL+N S TA +++ ++ +
Sbjct: 4017 TY-----LDLLCSMCDLSNA--SVKTTAKDIQQTEQTI 4047
Score = 157 bits (398), Expect = 1e-37
Identities = 494/2694 (18%), Positives = 1025/2694 (38%), Gaps = 459/2694 (17%)
Query: 413 ETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE 472
E ++ L WE L+ EKQ L+ L + Q + L TK E K+ E
Sbjct: 5859 EPSATAKLGDLQRSWETLKNVISEKQRTLYEAL-ERQQKYQDSLQSISTKMEAIELKLSE 5917
Query: 473 EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV---VVVDESSGDHATA-ALEEQ 528
P + Q+ +H+ L +++ Q +N L + +V + D A AL+
Sbjct: 5918 SP--EPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQST 5975
Query: 529 LKVLGDRWANICRWTEDRWVLLQDIL---LKWQRLTEEQCL---------FSAWLSEKED 576
L VL +R + I + LL++ L L+ QR +EQ L +WL +
Sbjct: 5976 LTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQR--QEQALQRYRCEADELDSWLLSTKA 6033
Query: 577 AVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKT 636
++ + K+ +M + L + ++E+K ++ +L ++LL L+ K+ T+
Sbjct: 6034 TLDTALSPP-KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL--LEGKAHTKDE 6090
Query: 637 EAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMET----VTTVTTREQILV 692
L R +L+ S ++ +A+ Q ++ Q T E V T+ +
Sbjct: 6091 AEQLAGKLR-------RLKGSLLELQRALHDKQLNM-QGTAQEKEESDVDLTATQSPGVQ 6142
Query: 693 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 752
+ + Q++ + E+ + L + L S +R E +L
Sbjct: 6143 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL-------------- 6188
Query: 753 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFC 812
I+ AE DA L +++ EG + A +Q+ +W
Sbjct: 6189 ---------IQHSAAETSG---DAGEKPDVLSQELGMEGEKSS----AEDQMRMKWESLH 6232
Query: 813 QLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK--IQPTTPSEPTAIKSQLKICK 870
Q S + L+ N++ Q+ EQ+ + N L + PT KS +
Sbjct: 6233 QEFSTKQKLLQ---NVLE-----QEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV---- 6280
Query: 871 DEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQT 930
+ L GL E + QS K + + H +Q D
Sbjct: 6281 --TSLLDGLNQAFEEVSSQSGGAKRQ--------------SIHLEQKLYD---------- 6314
Query: 931 IFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS 990
+SA TW+ E +L + + E E L + L ++E
Sbjct: 6315 ------------GVSATSTWLDDVEERLFVATALLP--EETETCLFNQEILAKDIKEMSE 6360
Query: 991 GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIE-------GRWKKLSSQLVEHCQKLEEQM 1043
+ + +K S+ + + IE GR L S + + C +++E++
Sbjct: 6361 EM--------DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERL 6412
Query: 1044 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNS 1103
++ QN ++ L +A+ + ++ + + + +Q++ + ++ +
Sbjct: 6413 QQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPV-AEQIEAIQQAEDGLKEFDAGIIE 6471
Query: 1104 VNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLS 1163
+ G K++ E +P EL +L +D + + +R+ L L ++ L
Sbjct: 6472 LKRRGDKLQVE-QPSM-----QELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 6525
Query: 1164 EMHEWMTQAEEEYL-ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1222
++ + + +E+ ++ + +E+Q+ ++ + KE Q E+ + +LTE++ I
Sbjct: 6526 DLADLLETGQEKMAGDQKIIVSSKEEIQQLLD---KHKEYFQGLESHM-ILTETLFRKII 6581
Query: 1223 QAPPVAQEALKKELE---TLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN 1279
A++KE + L + R + + LE + W L ++ ++ L
Sbjct: 6582 SF------AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLE 6635
Query: 1280 EVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIR-ILAQTLTDG--------- 1329
VE + + G EE + L L +H + + N+ + L Q L DG
Sbjct: 6636 VVESSIPSV----GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISC 6691
Query: 1330 GVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ---ESLTFID 1386
++ +N+ E + S ++ +E R + +L+ + E+ +H +Q + L F
Sbjct: 6692 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 6751
Query: 1387 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKK 1446
+Q + +PQE + ++ L + +E+ + K + +Q+ + KK
Sbjct: 6752 QQ----------SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQL-LRLKK 6800
Query: 1447 LQDVSMKFRLFQKPANFEQRLQESKMILDEV-KMHLPALETK----------SVEQEVVQ 1495
+ +++ L + + + L + +++ ++ + L ++ S+ + V+Q
Sbjct: 6801 VDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQ 6860
Query: 1496 SQLNHCVNL--YKSLSEVKSEV------------------EMVIKTGRQIVQKKQTENPK 1535
++ N YK++ E + + V++ Q V+ K+++
Sbjct: 6861 KDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK-T 6919
Query: 1536 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1595
+ E++ A+ + L VTE+ Q LE L+ + + L W + L ++
Sbjct: 6920 DFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHR 6979
Query: 1596 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE---TLVEDKLSLL 1652
+ G +++ + + + + I+ ++ ++ I + G AL + KKE ++V L L
Sbjct: 6980 I-GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLAL--IQNKKEDVSSIVMSTLREL 7036
Query: 1653 NSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDE-----SEKKKPQ 1707
W + + LL + D I ++++A L + Q
Sbjct: 7037 GQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQ 7096
Query: 1708 QKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRF----AAI 1763
+ D L+ L+ +L + L+ + + + E+N R+ I
Sbjct: 7097 VQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEI 7156
Query: 1764 SHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNE------ 1817
+ ++++ KA + L +++ ++ ++ + + L + NKD+ +D
Sbjct: 7157 AEQLQSSKALLQL--WQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQD 7214
Query: 1818 --------GTVKELL----QRGDNLQQRI----TDERKREEIKIKQQLLQTKHNALKDLR 1861
GTVK+ L + G+ L+Q++ + +++ + Q L + K
Sbjct: 7215 CNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQT 7274
Query: 1862 S--------QRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDR 1913
S + K+LE W +A+++L+ D D I+E
Sbjct: 7275 SLQAGVLDYETFAKSLEALEAWIV---EAEEILQGQDPSHSS--------DLSTIQERME 7323
Query: 1914 ELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ----LSKRWREIESKFAQFRRLNFAQ 1969
EL+ + + +++ + L+E G + + +I+ L++ W I S+ + R + Q
Sbjct: 7324 ELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTE--RFSKLQ 7381
Query: 1970 IHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFK 2029
++ +T + E + EI+ Q LLE ++ A +L ++F
Sbjct: 7382 SFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQR---AHELFQ---AEMFS 7435
Query: 2030 QEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 2089
+++ L +I II ++ L+ +R + L+ L QW+ V + +
Sbjct: 7436 RQQILHSI------------IIDGQR--LLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQ 7481
Query: 2090 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF----LRKTQIPENWEHAKYKWYLKELQ 2145
R+G D + +W+R+ + +WL E L IP + + +
Sbjct: 7482 QRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 7541
Query: 2146 DGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQ 2205
+ Q+ + + T+ A G++++ + + LQ +L + +W+ RLEEQ
Sbjct: 7542 VFLRQQGSYILTVEA-GKQLLLSADSGAEAALQAELAEIQEKWKSA-------SMRLEEQ 7593
Query: 2206 KNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQ-VKLLVEELPLRQGILK 2264
K L+ +D W E+ + + LE K + K+KL Q + EEL Q K
Sbjct: 7594 KKKLAFLLKD------W-EKCEKGIADSLE--KLRTFKKKLSQSLPDHHEELHAEQMRCK 7644
Query: 2265 QLNETGG------------PVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEI 2312
+L G +SA IS ++ L +++ QW ++ L ++ +I
Sbjct: 7645 ELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQI 7704
Query: 2313 EAQIKDLGQLEKKLEDLEEQLNHLLLWLSP-----IRNQLEIYNQPNQEGPFDVQETEIA 2367
++ + +K ++L E L + +S I +E + QE QE +I
Sbjct: 7705 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQ 7764
Query: 2368 VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGL 2427
+Q + E L+K H E A++ ++ KL ++ W+ LL + A+ L
Sbjct: 7765 LQ----QMGERLAKASH---ESKASE-IEYKLGKVNDRWQ---HLLDLIAARVKKL---- 7809
Query: 2428 TTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQ 2487
KET + A+ ++ + L WL+ ++
Sbjct: 7810 --------------------KETLV--------------AVQQLDKNMSSLRTWLAHIES 7835
Query: 2488 VIKSQRVMVG-DLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLK---NKTSNQEAR 2543
+ V + E+I + +Q+ +D+E+ + ++ + L + +
Sbjct: 7836 ELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAEC 7895
Query: 2544 TIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVL--GQARAKLES 2601
I + +W + RR ++ E + ++L+ E L + A S
Sbjct: 7896 DSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPS 7955
Query: 2602 WKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITEN 2661
YTV ++++ + + + + + T +++ N +L R+ D + +
Sbjct: 7956 SSGVIYTV--AKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHE 8013
Query: 2662 INASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLL 2721
N W ++ KRV+ L+ ++F + L WLTE + ++ + +
Sbjct: 8014 GNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECD--- 8070
Query: 2722 EDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFK 2781
V+ +KQ + Q EI + + + ++++ E DA +++ LD
Sbjct: 8071 -----VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPL-DAAIIEEELD----- 8119
Query: 2782 WSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQN 2841
ELR+ + +E R H + L+ L L DDE
Sbjct: 8120 --ELRRYCQEVFGRVE-------RYH----KKLIRLPLPDDE------------------ 8148
Query: 2842 DVHRAFKRELKTKEPVIMSTL----ETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVT 2897
H REL+ ++ +S L + L+ QP L +P R++
Sbjct: 8149 --HDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL------RSERSG 8200
Query: 2898 RLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERL--QELQEATDELDLKLRQA 2949
R + + EW+ H D R ++ + R E +E D+ D LR A
Sbjct: 8201 RDTPASVDSIPLEWD----HDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGA 8250
Score = 154 bits (388), Expect = 2e-36
Identities = 569/3082 (18%), Positives = 1166/3082 (37%), Gaps = 495/3082 (16%)
Query: 272 QQITVSLAQGYERTSSPKP----RFKSYAYTQAAYVTTSDPTRSPF----PSQHL-EAPE 322
+Q S+ Q E P+P +F + Q+ D TR+ S+ L E E
Sbjct: 2753 EQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTE 2812
Query: 323 DKSFGSSLMES-EVNLDRYQTALEEVLSWLLSAEDT----LQAQGEISNDVEVVKDQFHT 377
D+SF + E + + T +E + + L A E ++ + K++ H
Sbjct: 2813 DESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHR 2872
Query: 378 HEGYMMDLTAHQGRVGNILQL-GSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASME 436
D +A Q ++ I +L S+ IG +LS E + + N S E +
Sbjct: 2873 WSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTE--- 2929
Query: 437 KQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDL 496
M K+ D + +T+ + + + ++ QV Q L++ L
Sbjct: 2930 ---------MQALRADWKQWEDSVFQTQSCLENLVSQ-MALSEQEFSGQVAQ---LEQAL 2976
Query: 497 EQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLK 556
EQ + + + +++ + D + + + D TED LK
Sbjct: 2977 EQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTED---------LK 3027
Query: 557 WQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 616
Q E C FS LS V+ + K+ N + L K K++ +
Sbjct: 3028 SQ--LNELCRFSRDLSTYSGKVSGL----IKEYNCLC-----LQASKGCQNKEQILQQRF 3076
Query: 617 YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWD--NLVQKLEKSTAQISQAVTTTQPSLTQ 674
+D L N +T A+C+D + ++ S +I + ++ ++ +
Sbjct: 3077 RKAFRDFQQWLVNAKITT---------AKCFDIPQNISEVSTSLQKIQEFLSESENGQHK 3127
Query: 675 TTVM----ETVTTVTTRE-----QILVKHAQEE---LPPPPPQKKRQITVDSEIRKRLDV 722
+M E ++T+ T+E Q V A+E+ QK+ + K +V
Sbjct: 3128 LNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEV 3187
Query: 723 DITELHSWITRSEAVLQSPEFAIF------RKEGNFSDLKEKVNAIE------REKAEKF 770
+ W++++E ++ ++ R++ + E+++ E +EKA++
Sbjct: 3188 SAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL 3247
Query: 771 RKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIA 830
+ Q AS+S + V Q L+S+++ L E+++ L+ I+A
Sbjct: 3248 WEGQAASKSFRHRVSQ-----------------LSSQYLALSNLTKEKVSRLD---RIVA 3287
Query: 831 FYNQ----LQQLEQMTTTAENWLKIQPTTPSEPTAIKSQ-LKI-CKDEVNRLSGLQPQIE 884
+NQ +++L+ T A + L S+ + + S+ LK+ V + +Q ++
Sbjct: 3288 EHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMI 3347
Query: 885 RLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETM 944
+ +S+ +G + + + + + S + +L+ YQ+ +
Sbjct: 3348 VTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTS--YQDGV 3405
Query: 945 SAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSK 1004
W+ E L+ + + LG+ + L + S L + M++
Sbjct: 3406 RQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE 3465
Query: 1005 KAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVD 1064
+++ E ++++ R++ + + E K E+ + ++ Q ++ + W+ +
Sbjct: 3466 HYVTQL------ELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQ 3519
Query: 1065 VFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLE 1124
L + GD+ + L+ + L Q LNSV + + P+ R
Sbjct: 3520 EKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRA- 3578
Query: 1125 TELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYK 1184
L+ L W ++ + + K +++ ++ EW+ AEE+
Sbjct: 3579 --LESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK--------- 3627
Query: 1185 TPDELQKAVEEMKRAKEEAQQKEAKVK-LLTES-VNSVIAQAPPVAQEALKKELETLTTN 1242
K EE+ ++E ++ A+ + +L ES VNS + + LT+
Sbjct: 3628 ------KWHEEVTAYRDEVEEVGARAQEILDESHVNS-----------RMGCQATQLTSR 3670
Query: 1243 YQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEV- 1301
YQ L ++ + K LEE E S L + W K +N+ +++ V
Sbjct: 3671 YQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTH---KNFKNVATKIDKVDTVM 3727
Query: 1302 ----LDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRR 1357
L +LE L++ E + L ++ + G EE E R +E+H+ +
Sbjct: 3728 MGKKLKTLEVLLKDMEKGHS----LLKSAREKGERAVKYLEEGEAERLR-KEIHDHMEQL 3782
Query: 1358 QKLLEQSIQSAQETEKSLHLIQESLTFIDK--QLAAYIADKVDAAQMPQEAQ-------- 1407
++L + EK LHL +E F DK L +IA+ + +P+E +
Sbjct: 3783 KELTSTVRKEHMTLEKGLHLAKE---FSDKCKALTQWIAEYQEILHVPEEPKMELYEKKA 3839
Query: 1408 ------KIQSDLTSHEISLEEMKKHNQGK-EAAQRVL--SQIDVAQKKLQDV-SMKFRLF 1457
+Q + SHE S++ +++ + E Q V +ID Q QD+ S+ +
Sbjct: 3840 QLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMM 3899
Query: 1458 QKPANFEQRLQESKM----ILDEVKMHLPALETKSVEQEVVQSQLNHCV------NLYKS 1507
++ A FE RL +M ++ + HL A ++V + ++ ++ +Y+S
Sbjct: 3900 EEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQS 3959
Query: 1508 LS-EVKSEVE-----MVIKTGRQIVQKKQTENPKELDERVTALKL--HYNEL-------- 1551
L E++ V + VQ +P+ R A+K H+ L
Sbjct: 3960 LEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYL 4019
Query: 1552 ------------GAKVTERK-QQLEKCLKLSRKMRKEMNVLTEW-------------LAA 1585
K T + QQ E+ ++ +K+ + N+ W L
Sbjct: 4020 DLLCSMCDLSNASVKTTAKDIQQTEQTIE--QKLVQAQNLTQGWEEIKHLKSELWIYLQD 4077
Query: 1586 TDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLK--SITEVGEALKTVLGKKET 1643
D +L ++ S L+ +A +Q + +K+ K S+ + E + + K+E+
Sbjct: 4078 ADQQLQN---MKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEES 4134
Query: 1644 LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD-------HITKWIIQADT 1696
+++ LN W+ + ++ NL L+ ++ ++ D + K+ + D
Sbjct: 4135 PEHKEINHLNDQWLDLCRQSN---NLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDN 4191
Query: 1697 LLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISEL 1756
L S+ + + LK+L L + + ++ +DQ ++ + ++LV+ Q S L
Sbjct: 4192 LA-RSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHL 4250
Query: 1757 NHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEE-------DFN 1809
R+ + IK K + + LE+ N + E +E +Q N+ E D
Sbjct: 4251 EQRWFQLEDLIKR-KIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMA 4309
Query: 1810 KDMNEDNEGTVKELLQRGDNLQQRITDE---------RKREEIKIKQQLLQTKHNALKDL 1860
+++ D+ EL + L+ I D +R+ I+ Q+ N L DL
Sbjct: 4310 QNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDL 4369
Query: 1861 RSQRRK---KALEISHQWYQYKRQADDLLKCLDD---IEKKLASLPEPRDERKIKEIDRE 1914
QRRK KAL Q+ QA ++ + + + LP+ + + +
Sbjct: 4370 VGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD-----VSKQVKT 4424
Query: 1915 LQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVR 1974
+ + L + + GL G + E T+ + S+ +++ + + + H ++
Sbjct: 4425 CKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQ 4484
Query: 1975 EETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL-CAKDFEDLFKQEES 2033
E LE + V + E + L+ ++ P++ + +L Q
Sbjct: 4485 E-----------LEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAK 4533
Query: 2034 LKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQG 2093
+NI + + + + L S V+ L E L+ L Q+ + + KD+
Sbjct: 4534 YQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFY 4593
Query: 2094 RFDRSVEKWRRFHYDIKIFNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQ 2152
+ ++ + + I++ Q L+E E QFLR +++P + + LQDG
Sbjct: 4594 KVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEE----ALSLQDGCRAIL 4649
Query: 2153 TVVRTLNATGEEIIQQSS---KTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 2209
V L +E+ Q+ T +K+ L + + +Q R LE+ +
Sbjct: 4650 DEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAY 4709
Query: 2210 SEFQRDLNEFVLWLEEAD------NIASIPLEP---------GKEQQLKEKLEQVKLLVE 2254
E ++ + L+ N ++P E G Q L++V + +E
Sbjct: 4710 QEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLE 4769
Query: 2255 EL-----PLR-QGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEK 2308
+L PL + Q+ G + + E + E+++ Q+ ++SR+L
Sbjct: 4770 DLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWL 4829
Query: 2309 QGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQ------------- 2355
+ ++A++ L+ L+D++E++ + + +++ L I N +
Sbjct: 4830 R-RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELI 4888
Query: 2356 ------------EGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE--------------- 2388
E D+QE A++ +Q + EI S+ Q Y+
Sbjct: 4889 SADLEHSLAELSELDGDIQE---ALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELL 4945
Query: 2389 ---------KPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVT 2439
+ A + +K +E S+E + L+EL + L P + G +
Sbjct: 4946 QLAGNGLDVESAEENLKSHMEFFSTE-DQFHSNLEELHSLVATLDPLIKPTGKEDLE--- 5001
Query: 2440 LVTQPVVTKETAISKLEMPSSLMLEVPALA-----DFNRAWTELTDWLSLLDQVIKSQRV 2494
Q V + E ++ S +++ D+ +A E+ + ++ ++ + +
Sbjct: 5002 ---QKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5058
Query: 2495 M-VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERI 2553
+ + E + + KA + + ++ L A L+ KT N ++ ++ + +
Sbjct: 5059 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLE-KTGNDASKATLSRSMTTV 5117
Query: 2554 QNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQ 2613
+W ++ Q++ + L + + + T + ++A +++ Q + KL + +
Sbjct: 5118 WQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELL 5177
Query: 2614 KKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA----DDTRKVHMIT---------- 2659
+ +L Q Q+ + + L +L+D +A ++ + IT
Sbjct: 5178 TLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQ 5237
Query: 2660 ENINASWRSIHKRVSEREAA----------LEETHRLLQ----QFPLDLEKFLAWLTEAE 2705
E + + + + + + +RE ++ET L + LE+ LTEA
Sbjct: 5238 EKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEAT 5297
Query: 2706 TTANVLQDATRKER-----------------LLEDSKGVKELMKQWQDLQGEIEAHTDVY 2748
++ +++ L E + +K + Q QD E+E
Sbjct: 5298 NHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLK-IRDQIQDKIKEVEQSKATS 5356
Query: 2749 HNLDENSQKILRSL---------------EGSDDAVLLQRRLDNMNFKWSELRKKSLNIR 2793
L QK+ + L + D +L LD N K EL ++
Sbjct: 5357 QELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMEL---DAAVQ 5413
Query: 2794 SHLEASSDQWKRLHLSLQELL-VWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELK 2852
LE + K L + +L + Q +R + + +++ N++ + ++
Sbjct: 5414 KFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIE 5473
Query: 2853 TKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWE 2912
+ + T+ + + L +E +E+ E A +T L+ T E
Sbjct: 5474 KAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEA--MTEKLQYLTSVYCT--E 5529
Query: 2913 KLNLHSADWQRKIDETLE----RLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQ 2968
K++ A+ R+ +E + RLQ LQ+A D+K +AE+ K LQ
Sbjct: 5530 KMSQQVAELGRETEELRQMIKIRLQNLQDAAK--DMKKFEAELKK-------------LQ 5574
Query: 2969 DHLEKVKALR-----GEIAPLKENVSHVNDLARQLTTL-----GIQLSPYNLSTLEDLNT 3018
LE+ +A G ++ LKE +SH L ++ +L +QL L ED+
Sbjct: 5575 AALEQAQATLTSPEVGRLS-LKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVA 5633
Query: 3019 RWKLLQVAV---EDRVRQLHEA 3037
L A+ E+ R H A
Sbjct: 5634 SLPLCHAALRLQEEASRLQHTA 5655
Score = 135 bits (341), Expect = 6e-31
Identities = 427/2267 (18%), Positives = 881/2267 (38%), Gaps = 317/2267 (13%)
Query: 419 QMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQK--LKELNDWLTKTEERTRKMEEEPLG 476
Q L SR++ L + +E+ L + L+ + L +DW T + + + +
Sbjct: 3663 QATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDK 3722
Query: 477 PDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM----VVVVDESSGDHATAALEEQLKVL 532
D + ++++ +VL +D+E+ + S V ++E + + + ++ L
Sbjct: 3723 VDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQL 3782
Query: 533 GDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVN-----KIHTTGFK 587
+ + + + + L+ L + +++ + W++E ++ ++ K+ K
Sbjct: 3783 KELTSTVRK----EHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKK 3838
Query: 588 DQNEMLSSLQKLAVLKADLEKKKQSMGK-LYSLKQDLLSTLKNKSVTQKTE--------- 637
Q SLQ+ + K + G+ L L QD+ TLK+K +++
Sbjct: 3839 AQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDV--TLKDKIDQLQSDYQDLCSIGK 3896
Query: 638 AWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTT------VMETVTTVTTREQIL 691
A ++ A D L K I Q Q L Q ++ + + + Q +
Sbjct: 3897 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 3956
Query: 692 VKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQ-SPEFAIFRKEG 750
+ + EL RQ T+ + +W++ + L+ SP+ + R E
Sbjct: 3957 YQSLEHELQK---HVSRQDTLQ------------QCQAWLSAVQPDLEPSPQPPLSRAE- 4000
Query: 751 NFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEG-----VNADSIKQASEQLN 805
AI++ K FR LQ+ +R+ L+ M + A I+Q + +
Sbjct: 4001 ----------AIKQVK--HFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIE 4048
Query: 806 SRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQ 865
+ ++ L W E ++ + LQ +Q + + + E ++
Sbjct: 4049 QKLVQAQNLTQ---GWEEIKHLKSELWIYLQDADQQLQNMK-----RRHSELELNIAQNM 4100
Query: 866 LKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDV--QA 923
+ KD V +L Q + + + L +K + P + NH + D+ Q+
Sbjct: 4101 VSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEI------NHLNDQWLDLCRQS 4154
Query: 924 REKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQS 983
LQ D Y + M+ + ++++ T+ L+ +D E L L+ L
Sbjct: 4155 NNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWD--NLARSDAESTAVHLEALKKLAL 4212
Query: 984 SLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQM 1043
+LQE++ + L ++M + + + + +E RW +L + Q +
Sbjct: 4213 ALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNL 4272
Query: 1044 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNS 1103
+L +Q+ Q L +W E + E ++ + L + S+++ Q L S
Sbjct: 4273 EELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKS 4332
Query: 1104 VNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLS 1163
+ + ++ + ++ L + + + + V R++ L L + +
Sbjct: 4333 LIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVF 4392
Query: 1164 EMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQ 1223
+ + Q E + + R+ PD++ K V+ K A +A +K V + AQ
Sbjct: 4393 QATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSA-------QASLKTYQNEVTGLWAQ 4445
Query: 1224 APPVAQEALKKE-------LETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANK 1276
+ +E ++E L+ L + Y + + + + + LE+ +KA
Sbjct: 4446 GRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACH 4505
Query: 1277 WLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQT---------LT 1327
WL + + N+ + E+ L +N++ S + N + L +T
Sbjct: 4506 WLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEV 4565
Query: 1328 DGGVMDELINEELETFN-------SRWRELHEEAVRRQK---LLEQSIQSAQETEKSL-- 1375
D + E +N FN ++ ++ E + R++ L+E + QS E E
Sbjct: 4566 DHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLR 4625
Query: 1376 -------HLIQESLTFIDKQLA-----AYIADKVDAAQMPQE-----AQKIQSDLTSHEI 1418
++E+L+ D A A + + VD +E Q Q D H +
Sbjct: 4626 MSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLV 4685
Query: 1419 SL-------------------EEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSM----KFR 1455
+L ++H + + +R L + Q K+ + ++ K +
Sbjct: 4686 TLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK 4745
Query: 1456 LFQKPANFEQRLQESKMILDEVKMHL----PALETKSVE--QEVVQSQLNHCVNLYKSLS 1509
++ A LQ+S ++L V +HL P L+ + E + +QS L ++
Sbjct: 4746 MYHSLAG---SLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIG 4802
Query: 1510 EVKSEVEMVIKTGRQIVQK--KQTENPKELD--ERVTA-------LKLHYNELG---AKV 1555
E +E E ++VQ QTE + LD RV A L L+ ++ K+
Sbjct: 4803 ETVTECE------SRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKI 4856
Query: 1556 TERKQQLEKCLKLSRKM---RKEMNVLTEWLAATDME--LTKRSAVEGMPSNLDSEVAWG 1610
+++++ L++ + KE + L + D+E L + S ++G ++ +
Sbjct: 4857 QIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDG---DIQEALRTR 4913
Query: 1611 KATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLL 1670
+AT EI Q + +V +A L + L++ L N + V S AEE L
Sbjct: 4914 QATLTEIYSQ---CQRYYQVFQAANDWLEDAQELLQ-----LAGNGLDVES-AEENLKSH 4964
Query: 1671 LEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKA-ELNDIRPKVDS 1729
+E+ + F N++ + + D L+ KP KED+ +++ + EL R DS
Sbjct: 4965 MEFFSTEDQFHSNLEELHSLVATLDPLI------KPTGKEDLEQKVASLELRSQRMSRDS 5018
Query: 1730 TR--DQAANLMANRGDHCRKLVEPQISELNHRFAAISH--RIKTGKASIPLKELEQFNSD 1785
D A D+ +K E I +N +S +KT + E E+ S+
Sbjct: 5019 GAQVDLLQRCTAQWHDY-QKAREEVIELMNDTEKKLSEFSLLKTSSS----HEAEEKLSE 5073
Query: 1786 IQKLLEPLEAEIQQGVNLKEE--DFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI 1843
+ L+ + + ++ V L+E+ K N+ ++ T+ + + QR T R R
Sbjct: 5074 HKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSM---TTVWQRWT--RLRAVA 5128
Query: 1844 KIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1903
+ ++++L+ + + + KKA E+ Q Q K K + +L +L E
Sbjct: 5129 QDQEKILEDAVDEWTGF-NNKVKKATEMIDQ-LQDKLPGSSAEKA---SKAELLTLLEYH 5183
Query: 1904 DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFR 1963
D + EL++++ L +R+Q + +DGAA PT + +EI + Q R
Sbjct: 5184 DTFVL-----ELEQQQSALGMLRQQTLSMLQDGAA----PTPGEEPPLMQEITA--MQDR 5232
Query: 1964 RLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKD 2023
LN + V+ +V E E+ T+I V + E ++ L P + +
Sbjct: 5233 CLNMQE--KVKTNGKLVKQELKDREM------VETQINSVKCWVQETKEYLGNPTI---E 5281
Query: 2024 FEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEK 2083
+ ++ + L + +Q+ ++ +K L + P E + LQ A LD K
Sbjct: 5282 IDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSE-LSLQLAEVALDL---K 5337
Query: 2084 VNKMYKDRQGRFDRSVEKWRRFHYDI-KIFNQWLTEAEQFLRKTQIPENWEHAKY-KWYL 2141
+ +D+ ++S + I K+ T + KT +N AK + L
Sbjct: 5338 IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKT---DNVVQAKTDQKVL 5394
Query: 2142 KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKR 2201
E DG + + L+A ++ ++Q+ + L +K+G L Q+ +Q +R +
Sbjct: 5395 GEELDGCNSK---LMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTIRQAENRLSK 5450
Query: 2202 LEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQG 2261
L + + L E+ L + W+E+A +A + QL+E+ + L+EE
Sbjct: 5451 LNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS 5510
Query: 2262 ILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQ 2321
L+ + E + S +K+ ++ + + ++ + + + ++ KD+ +
Sbjct: 5511 ELEAMTEK-----LQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKK 5565
Query: 2322 LEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSK 2381
E +L+ L+ L Q T + + + ++E LS
Sbjct: 5566 FEAELKKLQAALE-------------------------QAQATLTSPEVGRLSLKEQLSH 5600
Query: 2382 GQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2441
QHL E +E L + +AV LR + D+ L A+ + L
Sbjct: 5601 RQHLLSE----------MESLKPKVQAVQLCQSALRIPE-DVVASLPLCHAA----LRLQ 5645
Query: 2442 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2501
+ + TAI + + + +++ + + L + + I+ + V ++++
Sbjct: 5646 EEASRLQHTAIQQCNIMQAAVVQ---YEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQE 5702
Query: 2502 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITD 2548
+ I + + Q ++ + Q+ L + + L K + +T+
Sbjct: 5703 LQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE 5749
Score = 129 bits (323), Expect = 7e-29
Identities = 269/1454 (18%), Positives = 572/1454 (39%), Gaps = 260/1454 (17%)
Query: 315 SQHLEAPEDK--SFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEI-SNDVEVV 371
SQHL A E +SL ++ + + +LE + +W++ AE+ LQ Q S+D+ +
Sbjct: 7259 SQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTI 7318
Query: 372 KDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLR 431
+++ +G M+ ++ + + +LG +L K E++ NL N W +
Sbjct: 7319 QERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK-------EIKRMQNL-NRHWSLIS 7370
Query: 432 VASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 491
+ E+ S L L+ Q L++ W+ + +K+ E G + + L Q + H++
Sbjct: 7371 SQTTERFSKLQSFLLQHQTF-LEKCETWMEFLVQTEQKLAVEISG-NYQHLLEQQRAHEL 7428
Query: 492 LQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ----LKVLGDRWANICRWTEDRW 547
Q ++ Q + H +++ + + ++ L +L ++W + R + R
Sbjct: 7429 FQAEMFSRQ----QILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 7484
Query: 548 VLLQDILLKWQRLTEEQCLFSAWLSEKE---------------------DAVNKIHTTGF 586
++ + +WQR E WL E D V
Sbjct: 7485 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 7544
Query: 587 KDQNEMLSSLQ--KLAVLKADLEKKKQSMGKLYSLKQDLLS-TLKNKSVTQKTEAWLDNF 643
+ Q + +++ K +L AD + +L +++ S +++ + +K L ++
Sbjct: 7545 RQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDW 7604
Query: 644 ARCWDNLVQKLEK------------------------STAQISQAVTTTQPSLTQTTVM- 678
+C + LEK ++ AV + LTQ +++
Sbjct: 7605 EKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLK 7664
Query: 679 ETVTTVTTREQI--------LVKHAQEELPPPPPQKKRQI-------TVDSEIRKRLDVD 723
+T++ + + I L++ EEL +++QI V SE K L
Sbjct: 7665 DTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW 7724
Query: 724 ITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQAL 783
+T++ S ++++ +L +K D +E++ AI +E K + Q R A+A
Sbjct: 7725 LTQMESKVSQNGDILIEEMIEKLKK-----DYQEEI-AIAQE--NKIQLQQMGERLAKAS 7776
Query: 784 VEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 843
E +E I+ ++N RW L++ R+ L + ++A +QQL++ +
Sbjct: 7777 HESKASE------IEYKLGKVNDRWQHLLDLIAARVKKL--KETLVA----VQQLDKNMS 7824
Query: 844 TAENWLKIQPTTPSEPTAIKS-QLKICKDEVNRLSGLQPQIER--------LKIQSIALK 894
+ WL + ++P S + + ++N LQ IE+ L + + L
Sbjct: 7825 SLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 7884
Query: 895 EKGQGPMFLDADFV-AFTNHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWV 951
+ + D + T + + + ++ A E + + + ++ + S W+
Sbjct: 7885 DCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 7944
Query: 952 QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 1011
+ SE + P S Y + ++ L + +A Q + E + L ++ + ++++ ++ +
Sbjct: 7945 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 8004
Query: 1012 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1071
+ E RW L ++ ++L+ + + + + ++ W+ E+D+ L
Sbjct: 8005 CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL-TNI 8063
Query: 1072 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1131
+ ++ K +KQ + +I + + G+++ ++EP A+ +E EL EL
Sbjct: 8064 EHFSECDVQAK-IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 8122
Query: 1132 TQWDHMCQQVYARKEALKGGL-------------EKTVSLQKD--LSEMHEWMTQAEEEY 1176
CQ+V+ R E L ++ + L+ LS++H W ++ +
Sbjct: 8123 ----RYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLH-WHDRSADSL 8177
Query: 1177 ----------------------------------LERDFEYKTPDELQKAVEEMKRAKEE 1202
LE D +Y +L+ A+ +++E
Sbjct: 8178 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 8237
Query: 1203 AQQKEAKVKLL-TESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1261
Q + L ++ V+ P + EA K E N +G LE
Sbjct: 8238 EGQDDKDFYLRGAVGLSDVMI---PESPEAYVKLTENAIKN-------TSGDHSALE--- 8284
Query: 1262 ACWHELLSYLEKANKWLNEVEFKLKTTENI-----PGGAE-------------EISEVLD 1303
S + + K L++ F+++ TENI P G E E S +D
Sbjct: 8285 -------SQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID 8337
Query: 1304 S---LENLMRHSEDN-PNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQK 1359
S LE+ ++ E++ P + + + GV+D RW L +A+ ++
Sbjct: 8338 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVID------------RWELLQAQALSKEL 8385
Query: 1360 LLEQSIQSAQ--------------ETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQE 1405
++Q++Q Q +TE+ L +Q D Q K+ Q +
Sbjct: 8386 RMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVD 8445
Query: 1406 AQK---IQSDLTSHEISLEEMKKH-------NQGKEAAQRVLSQIDVAQKKLQDVSMKFR 1455
+K + +L S E + + K+ +Q RV S ++ + LQD M+ +
Sbjct: 8446 HRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQ 8505
Query: 1456 LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEV 1515
F + ++ + E+ +D K + +++ +++ E++Q + + L E + V
Sbjct: 8506 GFHEMSHGLLLMLEN---IDRRKNEIVPIDS-NLDAEILQDHHKQLMQIKHELLESQLRV 8561
Query: 1516 EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 1575
+ Q++ + + E E+V + L +V+ ++LEK L +S +
Sbjct: 8562 ASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQD- 8620
Query: 1576 MNVLTEWLAATDME 1589
L+ W +A +++
Sbjct: 8621 ---LSSWSSADELD 8631
Score = 119 bits (298), Expect = 6e-26
Identities = 407/2222 (18%), Positives = 875/2222 (39%), Gaps = 318/2222 (14%)
Query: 945 SAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSK 1004
S +++W+ + + S+ QL +E S EQ Y + EM
Sbjct: 528 SKLKSWIIKYGRRESVEQLLQNYVSFIEN---------SKFFEQYEVTYQILKQTAEMYV 578
Query: 1005 KAPSEI--SRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1062
KA + + E +W+ LS ++ LEE ++ + N + +L+ W+ +
Sbjct: 579 KADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLED 638
Query: 1063 VDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASR 1122
+ L + SE KK R L IQ ++N+ G + + +
Sbjct: 639 AEKMLNQ-------SENAKKDF--FRNLPHWIQ----QHTAMNDAGNFLIETCDEMVSRD 685
Query: 1123 LETELKELNTQWDHMCQQV--YARKEAL----KGGLEKTVSLQKDLSEMHEWMTQAEEEY 1176
L+ +L LN +W + +V YA+ + + K + V+L +E H+ ++ E
Sbjct: 686 LKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLS----EP 741
Query: 1177 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPP-------VAQ 1229
LE F ++ +++++ ++ +A+ K++T++ + + ++P
Sbjct: 742 LEVSFM-----NVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 796
Query: 1230 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE------- 1282
LK++L + Y L LEE+ L K N+ + +E
Sbjct: 797 SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSA 856
Query: 1283 -FKLK-------------TTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD 1328
FK K T I G++ + + + +L N+++H + Q +I +
Sbjct: 857 LFKQKHQELLACQENCKKTLTLIEKGSQSVQKFV-TLSNVLKHFDQTRLQRQIADIHVAF 915
Query: 1329 GGVMDELIN--EELETFNSRWRELHEEAVRRQKLL---EQSIQSAQETEKSLHLIQESLT 1383
++ + + + +ET + ++ E +K+L ++ ++ + E+ L E +
Sbjct: 916 QSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFS 975
Query: 1384 FIDKQ-LAAYI--ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQI 1440
+D++ L A++ D++ QE Q +Q + L + K QG+ + +I
Sbjct: 976 QLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRK----LHKQWKDLQGEAPYHLLHLKI 1031
Query: 1441 DVAQKKL--------QDVSMKFRLFQKPANFEQRLQESKMIL-DEVKMHLPALETKSVEQ 1491
DV + + ++ + +L + + E+ ++E ++ D+ HL + +E+
Sbjct: 1032 DVEKNRFLASVEECRTELDRETKLMPQEGS-EKIIKEHRVFFSDKGPHHLCEKRLQLIEE 1090
Query: 1492 EVVQSQLNHCVN-----LYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 1546
V+ + V + +L E+++ ++ + K E+P + + +
Sbjct: 1091 LCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYR--------KLMEDPDKWKDYTS---- 1138
Query: 1547 HYNELGAKVTERKQQLE--KCLKLSRKMRKEMNVLTEWLAATDMELTKRS-AVEGMPSNL 1603
++E + ++ + QL+ K + E+ E + +TKR + + S L
Sbjct: 1139 RFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNG---VTKRGETLSWLKSRL 1195
Query: 1604 DSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRA 1663
+V +++ E +KQ L ++ +AL T+L + E ++ + + I V +
Sbjct: 1196 --KVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEI-VKNSL 1252
Query: 1664 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDI 1723
EE ++ E Q+ E T+ + +A LL ++K KR+ A+ D+
Sbjct: 1253 EELISGSKEVQEQAEKILD-----TENLFEAQQLLLHHQQKT--------KRISAKKRDV 1299
Query: 1724 RPKVDSTRDQAANLMANRGDHCRKLVEP-----QISELNHRFAAIS----HRIKTGKASI 1774
+ ++ + L + RKL + E R ++ R +T K ++
Sbjct: 1300 QQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETV 1359
Query: 1775 PLKELEQFNSDIQKLL-----EPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1829
++ L Q S ++ L E L +E++Q + + + +N + G
Sbjct: 1360 -VRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQ 1418
Query: 1830 LQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCL 1889
+Q + + K IK+Q+ + + +D+++ K +W + + L +
Sbjct: 1419 NKQLLQQQAK----SIKEQVKKLEDTLEEDIKTMEMVKT-----KWDHFGSNFETLSVWI 1469
Query: 1890 DDIEKKLASLPEPRD--ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ 1947
+ EK+L +L + +I +I +Q+ + +L+++ GL E+ + A Q
Sbjct: 1470 TEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSI----VGLEEEAQSFA----QFV 1521
Query: 1948 LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL 2007
+ I++K Q RR +RE + E L + + + Q++
Sbjct: 1522 TTGESARIKAKLTQIRRYG----EELREHAQCL--EGTILGHLSQQQKFEENLRKIQQSV 1575
Query: 2008 LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-E 2066
E E L P + +K + ++ +L+ S I TA SA V
Sbjct: 1576 SEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAI-------TAFSASARKVVN 1628
Query: 2067 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT 2126
R + + L Q+E + + K+RQ + + W+R ++ F WL E
Sbjct: 1629 RDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSP 1688
Query: 2127 QIPENWEHAKYKWYL---KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGS 2183
++ + + K + L + LQ+ + + + L E + +SK D +++ L
Sbjct: 1689 EMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQ 1748
Query: 2184 LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLW----LEEADNIASIPLEPGKE 2239
L+ RW+++ + ++ R L+ +F L F +W L E + I + +
Sbjct: 1749 LDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV 1808
Query: 2240 --QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQ 2297
+ K+ +V+ EL QG L +L G E+ L+ K +
Sbjct: 1809 ALTRHKDHAAEVESKKGELQSLQGHLAKLGSLG---------RAEDLHLLQGKAEDCFQL 1859
Query: 2298 WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI-RNQLEIYNQPNQE 2356
+ + S+ + +Q + + + + Q L + QL + + + +N+ ++ +
Sbjct: 1860 FEEASQVVERRQLAL-SHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLN- 1917
Query: 2357 GPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQ--PVKRKLEDLSSEWKAVNRLLQ 2414
D + A+++ ++ ILSK Q+ K + Q + + L E + + LL
Sbjct: 1918 ---DALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLG 1974
Query: 2415 ELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRA 2474
+++ LA + + + + + T +L+ P+ L+ L FN+
Sbjct: 1975 TKQSEADALAVLKKAFQDQKEELLKSIED--IEERTDKERLKEPTRQALQ-QRLRVFNQL 2031
Query: 2475 WTELTD------WL-SLLDQVIKSQRVMVGDLE-DINEMIIKQKATMQDLEQRRPQ---L 2523
EL WL Q+ + +++ +IN + + T + + + + Q L
Sbjct: 2032 EDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGL 2091
Query: 2524 EELITAAQNLKNKTSN--QEARTIITDRI---------------ERIQNQWDEVQEHLQN 2566
+L+ QNLK+ S + A ++I R E +N+ + Q+ L N
Sbjct: 2092 IDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDN 2151
Query: 2567 ----RRQQLNEMLK-------------DST--QWLEAKEEAEQVLGQARAKLESWKEGPY 2607
+ L+E+ K +ST +WL+ E+ E+ + + R L W +
Sbjct: 2152 FTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLS 2211
Query: 2608 TVDAIQKKITE-TKQLAKDLRQWQTNVDVANDL-ALKLLRDYSADDTRKVHMITENINAS 2665
T D I+ Q+A+++ +N+D N L A +LL+++ ++ K + E
Sbjct: 2212 TRDEIEGWSNNCVPQMAENI----SNLD--NHLRAEELLKEFESEVKNKALRLEE----- 2260
Query: 2666 WRSIHKRVSEREAALE--ETHRLLQQFPLDLEKFLAWLTE-AETTANVLQD----ATRKE 2718
+H +V++ + + ET LQ DL + L E E L+D +T+ E
Sbjct: 2261 ---LHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVE 2317
Query: 2719 RLLED----------------SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSL 2762
+ + D E +K+ +D+Q E+++ + EN + R
Sbjct: 2318 KFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKY 2377
Query: 2763 EGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDD 2822
S + L R + + K + + ++ L+ S + K S+QE W
Sbjct: 2378 H-SAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE--KHFSESMQEFQEWF----- 2429
Query: 2823 ELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2882
+G A K++ + L+ K + + L++V L+ + Q
Sbjct: 2430 -------LGA--KAAAKESSDRTGDSKVLEAKLHDLQNILDSV-----SDGQSKLDAVTQ 2475
Query: 2883 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 2942
E + L Q V+ +++Q + N E++ ++ + + L ++ +L
Sbjct: 2476 EGQTLYAHLSKQIVSS-IQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2534
Query: 2943 DLKLRQAEVIKGSWQPVGDLL--IDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 3000
+L + + E + + + +G+ I ++ + KV+ GE+ +E++ ++ + L+
Sbjct: 2535 NLWIHEMEE-RFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2593
Query: 3001 LG 3002
G
Sbjct: 2594 EG 2595
Score = 102 bits (255), Expect = 5e-21
Identities = 349/2049 (17%), Positives = 781/2049 (38%), Gaps = 297/2049 (14%)
Query: 318 LEAPEDKSFGSSLMESEVNLDRYQTALEEVLSW---LLSAEDTLQAQGEISNDVEV---- 370
L PE+ L E + L +Y++ + VLS + S + +A E+ DV +
Sbjct: 3824 LHVPEEPKM--ELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKI 3881
Query: 371 ------VKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGT------GKLSEDEETEVQE 418
+D + M ++ + R+ N+ G LIG KL ++ +Q
Sbjct: 3882 DQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQG 3941
Query: 419 QMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQK-LKELNDWLTKTEERTRKMEEEPLGP 477
+ ++ A QS H + + Q L++ WL+ + + PL
Sbjct: 3942 TKDSYSA---ICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSR 3998
Query: 478 DLEDLKRQVQQHKVLQE------DLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 531
+ +QV+ + LQE DL +++ + D + Q +
Sbjct: 3999 --AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQN 4056
Query: 532 LGDRWANICRWTEDRWVLLQDILLKWQRLTE-----EQCLFSAWLSEKEDAVNKIHTTGF 586
L W I + W+ LQD + Q + E + +S+ +D V K+ +
Sbjct: 4057 LTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ- 4115
Query: 587 KDQNEMLSSLQKLAVLKADLEKK-------------KQSMGKLYSLKQDLLSTLKNKSVT 633
N ++ + KL + E K +QS ++DL T
Sbjct: 4116 ASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCM 4175
Query: 634 QKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK 693
E +L+ F WDNL + +STA +A+ +L + + + ++Q +++
Sbjct: 4176 NVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKY--AIEDLKDQKQKMIE 4233
Query: 694 HAQ---EELPPPPPQ--KKRQITVDSEIRKRLDVDIT-------------ELHSWITR-- 733
H +EL ++R ++ I++++ V +T EL W
Sbjct: 4234 HLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQ 4293
Query: 734 ---SEAVLQSP-----EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVE 785
+EA+ QSP + + S+L+ K ++ + R + D + + +++
Sbjct: 4294 PNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQ 4353
Query: 786 QMVNEGVN-----ADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ 840
+ +++ + +D + Q + LN + LSE+ +L + +Q+QQ E+
Sbjct: 4354 KALSDAQSHVNCLSDLVGQRRKYLN-------KALSEKTQFLMA---VFQATSQIQQHER 4403
Query: 841 MTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGP 900
E+ + P + Q+K CK L Q ++ L Q L ++
Sbjct: 4404 KIMFREHICLL-------PDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVT-- 4454
Query: 901 MFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTL----------------PPMRYQETM 944
+Q S+V + +ELQ+++D++ ++E
Sbjct: 4455 --------------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDF 4500
Query: 945 SAIRTWVQQSETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMS 1003
W++Q++ ++ P++++ + + +L + Q + E ++ L L T + +
Sbjct: 4501 DKACHWLKQADI-VTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTIL 4559
Query: 1004 KKAPSEISRKYQSE-FEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1062
+E+ Y SE + ++ + + + K++E + ++ + I+ + ++E
Sbjct: 4560 PSL-NEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSE 4618
Query: 1063 VDV-FLK-EEWPA-LGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEF 1119
++ FL+ + P L E L Q CR ++ ++ + +++ +N+ + ++ +P
Sbjct: 4619 LEAQFLRMSKVPTDLAVEEALSLQ-DGCRAILDEVAGLGEAVDELNQKKEGFRSTGQP-- 4675
Query: 1120 ASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLS---EMHEWMTQAEEEY 1176
Q D M V LK E+ VSL +D + + HE M Q E
Sbjct: 4676 ------------WQPDKMLHLV-TLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQ 4722
Query: 1177 LE--RDFEYKTPDELQKAVEEMKRAKEEA---QQKEAKVKLLTESVNSVIAQAPPVAQEA 1231
L+ ++ + K +E A E++K A Q +K +T + + P+A E
Sbjct: 4723 LKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK 4782
Query: 1232 LKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENI 1291
+ ++++ + L + + E + + + ++ WL V+ +L +
Sbjct: 4783 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYL 4842
Query: 1292 PGGAEEISEVLDSLENLMRHSEDNPNQIRI----------------------LAQTLTDG 1329
++I E + + H E+ + +RI L +L +
Sbjct: 4843 DLNLQDIQE---EIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAEL 4899
Query: 1330 GVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQL 1389
+D I E L T + E++ + R ++ + + ++ ++ L L L +
Sbjct: 4900 SELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDV--ESA 4957
Query: 1390 AAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQD 1449
+ ++ + +L S +L+ + K ++ Q+V S +Q+ +D
Sbjct: 4958 EENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5017
Query: 1450 VSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLS 1509
+ L Q+ Q+++ +EV + E K E ++++ +H + LS
Sbjct: 5018 SGAQVDLLQRCTAQWHDYQKAR---EEVIELMNDTEKKLSEFSLLKTSSSH--EAEEKLS 5072
Query: 1510 EVKSEVEMVIKTGRQIVQKKQTENPKE----------LDERVTALKLHYNELGAKVTERK 1559
E K+ V +V +IV ++ + E L +T + + L A +++
Sbjct: 5073 EHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQE 5132
Query: 1560 QQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1619
+ LE + ++ TE + +L SA + + L + + + E+E+
Sbjct: 5133 KILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQ 5192
Query: 1620 QKVHL-----KSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 1674
Q+ L ++++ + + G++ L+++ ++ + + + + + L+ +
Sbjct: 5193 QQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQE-ITAMQDRCLNMQEKVKTNGKLVKQEL 5251
Query: 1675 KHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQA 1734
K E + ++ + W+ + L + Q E+ L+ L E + R ++ ++
Sbjct: 5252 KDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEE-LQILLTEATNHRQNIEKMAEEQ 5310
Query: 1735 ANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT-GKASIPLKELEQFNS--------- 1784
L SEL+ + A ++ +K + +KE+EQ +
Sbjct: 5311 KEKYLG-------LYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQI 5363
Query: 1785 -----DIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERK 1839
D+ +L L+A+ V K + K + E+ +G +L++ +Q+ + +
Sbjct: 5364 QKLAKDLTTILTKLKAKTDNVVQAKTDQ--KVLGEELDGCNSKLMELDAAVQKFLEQNGQ 5421
Query: 1840 REEIKIKQ--QLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLA 1897
+ K+ +L + ++ ++ K SH +Y + +LK ++ K LA
Sbjct: 5422 LGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHL-EEYNEMLELILKWIEKA-KVLA 5479
Query: 1898 -------SLPEPRDE--------RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVE 1942
S + R++ + KEID EL+ E+L + + E
Sbjct: 5480 HGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLT----------SVYCTE 5529
Query: 1943 PTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITH 2002
Q+++ RE E Q+ +R + + +DM + E+
Sbjct: 5530 KMSQQVAELGRETEE---------LRQMIKIRLQNLQDAAKDM--------KKFEAELKK 5572
Query: 2003 VSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSA 2062
+ AL + + L +P++ ++ + L + +SL+ ++ + ++A
Sbjct: 5573 LQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKP---KVQAVQLCQSALRIPE 5629
Query: 2063 TPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQF 2122
V + L A +L + ++ + +V ++ ++ ++K Q + A +
Sbjct: 5630 DVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHRE 5689
Query: 2123 LRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLG 2182
+ + + ++ELQ I + + + + + E+I +SK ++ K
Sbjct: 5690 IEDKPVATS--------NIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHA 5741
Query: 2183 SLNLRWQEV 2191
++ L EV
Sbjct: 5742 TMLLTVTEV 5750
Score = 52.4 bits (124), Expect = 8e-06
Identities = 152/832 (18%), Positives = 314/832 (37%), Gaps = 147/832 (17%)
Query: 2248 QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQD---KLENKLKQTNLQWIKVSRA 2304
Q++ L LP Q + + V P P ++ K++ K+ L+W++ +
Sbjct: 141 QIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAG 200
Query: 2305 LPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQET 2364
KQ IE +KD G+ + ++ + L + N+ N E F + ET
Sbjct: 201 ---KQTGIE--VKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAET 255
Query: 2365 EIA---------VQAKQPDVEEILSKGQHLYKEKPAT-------QPVKRKLEDLSSEWKA 2408
E+ V +PD + I++ K P Q L S +
Sbjct: 256 ELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANS 315
Query: 2409 VNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTK------------------ET 2450
V +E R ++ + T+ +V + K E
Sbjct: 316 VQNFKREDRVIFKEMKVWIEQFERDLTRA-QMVESNLQDKYQSFKHFRVQYEMKRKQIEH 374
Query: 2451 AISKLEMPSSLMLEVPALAD-FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQ 2509
I L L L+ + ++R + L DW LD+ + + +G E+ +++
Sbjct: 375 LIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALRE 434
Query: 2510 KATMQDLEQR-----RPQLEELITAAQNLK--NKTSNQEARTIITDRIERIQNQWDEVQE 2562
+ T+Q + + + +LE+ QN + ++ RT + I +Q +++ E
Sbjct: 435 EITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAE 494
Query: 2563 --HLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESW--KEGPY-TVDAIQKKIT 2617
H + +L+ M ++LE K +L A +KL+SW K G +V+ + +
Sbjct: 495 RFHFVSSTSELHLM---KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYV 551
Query: 2618 ETKQLAKDLRQWQTNVDVANDLALKLLR-DYSADDTRKVHMITENINASWRSIHKRVSER 2676
+ +K Q++ + A ++ D S ++ V A WR++ V
Sbjct: 552 SFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSV 611
Query: 2677 EAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDA---------------------- 2714
+ LEE ++ + AWL +AE N ++A
Sbjct: 612 RSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAG 671
Query: 2715 -----TRKERLLEDSKGVKELMK-QWQDLQGEIEAH-------------TDVYHNLD--- 2752
T E + D K L+ +W++L E++ + TD L
Sbjct: 672 NFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFA 731
Query: 2753 -ENSQKILRSLEGS--------DDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQW 2803
E +K+ LE S D +++R+ M+ ++ + K + I E+ ++
Sbjct: 732 TEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITK--ESPQEEG 789
Query: 2804 KRLHLSLQELLVWL-QLKD----------------DELSRQAPIGGDFPAVQKQNDVHRA 2846
K + ++ +L L ++K+ +EL +Q + + ++ K N++
Sbjct: 790 KEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQ--MTSFYDSLGKINEIITV 847
Query: 2847 FKRE------LKTKEPVIMSTLETVRIFLT--EQPLEGLEKLYQEPRELPPEERAQNVTR 2898
+RE K K +++ E + LT E+ + ++K L ++ +
Sbjct: 848 LEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTR---- 903
Query: 2899 LLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAE 2950
L++Q +++ ++ + + DW++ ++ +++ +E+ EL+ LR A+
Sbjct: 904 -LQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQ 954
Score = 35.4 bits (80), Expect = 1.1
Identities = 32/140 (22%), Positives = 60/140 (42%), Gaps = 9/140 (6%)
Query: 2906 EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 2965
++ WE L ++ QR + E LER Q+ Q++ + K+ E+ G
Sbjct: 5868 DLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES 5927
Query: 2966 SLQDHLEKVKALRGEIAPLKENVSHV-NDLARQLTTLGIQLSPYN----LSTLEDLNTRW 3020
+ +H +AL EI L++ ++ + + LA +L + + P STL L R
Sbjct: 5928 QMAEH----QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 5983
Query: 3021 KLLQVAVEDRVRQLHEAHRD 3040
+++ + + L E D
Sbjct: 5984 STIRMKASGKRQLLEEKLND 6003
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 301 bits (772), Expect = 6e-81
Identities = 429/2052 (20%), Positives = 850/2052 (41%), Gaps = 278/2052 (13%)
Query: 6 SDEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKE-KGS 64
+DERE VQKKTFTKWVN+ ++ + + +L+SDL+DGR LL LLE L+G+ LPK KG
Sbjct: 52 ADEREAVQKKTFTKWVNSHLARVTCR-VGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGR 110
Query: 65 TRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIM 124
R+H L NV+KAL+ L+ V L N+GS DIVDGNH+LTLGL+W IIL +Q++++
Sbjct: 111 MRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETE 170
Query: 125 AGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVC 184
++ +++ LL W + T YP VNV NFTTSW DGLA NA++H HRPDL D+ S+
Sbjct: 171 DNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLK- 229
Query: 185 QQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVS---- 240
+ +A L++AFN+A +LG+ KLLDPEDV+ PD+KSI+ Y+ + + + +
Sbjct: 230 KCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVE 289
Query: 241 -------IEAIQEVEMLPRPPKVTKEEHFQLHHQMHYS---QQITVSLA------QGYE- 283
++ E E L + E Q Q + +Q+ SL+ Q +
Sbjct: 290 GKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNS 349
Query: 284 -RTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQT 342
RT P+F + T R+ +Q + P + S + ++ L++ +
Sbjct: 350 YRTVEKPPKFTEKGNLEVLLFTIQSKLRA--NNQKVYTPREGRLISDINKAWERLEKAEH 407
Query: 343 ALEEVL-------------------------SWLLSAEDTLQAQGEISNDVEVVKDQFHT 377
E L +W LS L +Q ++ V+
Sbjct: 408 ERELALRTELIRQEKLEQLAARFDRKAAMRETW-LSENQRLVSQDNFGLELAAVEAAVRK 466
Query: 378 HEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEK 437
HE D+ A+ GRV + + ++L + D + Q N+ W+ LR +
Sbjct: 467 HEAIETDIVAYSGRVQAVDAVAAEL--AAERYHDIKRIAARQHNVAR-LWDFLRQMVAAR 523
Query: 438 QSNLHRVLMDLQNQK----LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQ 493
+ R+L++L+ QK L L DW+ EE +++ + LG L ++ +Q H++++
Sbjct: 524 R---ERLLLNLELQKVFQDLLYLMDWM---EEMKGRLQSQDLGRHLAGVEDLLQLHELVE 577
Query: 494 EDLEQEQVRVNSLTHMVVVVDESSGDHATA---ALEEQLKVLGDRWANICRWTEDRWVLL 550
D+ + RV +++ + ++ + E++ L + +C R L
Sbjct: 578 ADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARL 637
Query: 551 QDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKK 610
++ W R E AW+ E++ + T +D L L K L+ ++ +
Sbjct: 638 EESRRLW-RFLWEVGEAEAWVREQQHLLASADTG--RDLTGALRLLNKHTALRGEMSGR- 693
Query: 611 QSMGKL-YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ 669
+G L +L+Q + + A W+ L E+ +++QA + Q
Sbjct: 694 --LGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQ 751
Query: 670 PSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHS 729
D ++ +
Sbjct: 752 --------------------------------------------------FQADANDMEA 761
Query: 730 WITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVN 789
W+ + ++ SPE E + L + A+E E+ R DA R A + ++
Sbjct: 762 WLVDALRLVSSPELG--HDEFSTQALARQHRALE-EEIRSHRPTLDALREQAAALPPTLS 818
Query: 790 EGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWL 849
++ L + E ER LE + ++ E WL
Sbjct: 819 ---RTPEVQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWL 875
Query: 850 K--IQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADF 907
P + ++ + + + E+N L+ + + Q + G+ + +
Sbjct: 876 NGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQ 935
Query: 908 VAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD 967
+ NH Q F + +K T L Y + + W+++ +TK+ +
Sbjct: 936 L---NHRWQQFRRLADGKKAALT--SALSIQNYHLECTETQAWMRE-KTKV------IES 983
Query: 968 YEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKA-------PSEISRKYQSEFEE 1020
+ + L + ALQ L + L ++ V E++++A P++ + + E
Sbjct: 984 TQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQ-AVAINARLRE 1042
Query: 1021 IEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTL---KKWMAEVDVFL-KEEWPA-LG 1075
++ W+ L + + ++ EE + + R++Q+ +++L + W+ + EE PA L
Sbjct: 1043 VQTGWEDLRATM----RRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLP 1098
Query: 1076 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI-KNEAEPEFASRLETELKELNTQW 1134
++E L L Q L +++ Q + + G+++ +++A+P+ L L+ L T W
Sbjct: 1099 EAEAL---LAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQ-CLFLRQRLEALGTGW 1154
Query: 1135 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMH--EWMTQAEEEYLERDFEYKTPDELQKA 1192
+ + + E+ +G L + Q L + E + ++E L + P LQ A
Sbjct: 1155 EELGRM----WESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHT---EMPGTLQAA 1207
Query: 1193 VEEMKRAKEEAQQKEA---KVKLLTESVNSVIAQAPPVAQEALKKELETLTTNY------ 1243
+K+ ++ +A ++ L E+ ++++ + + ++++ +++ +
Sbjct: 1208 DAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEG-NIHADKIREKADSIERRHKKNQDA 1266
Query: 1244 -QWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVL 1302
Q RL + + C HEL ++++ K L + N+ ++ +
Sbjct: 1267 AQQFLGRLRDNREQQHFLQDC-HELKLWIDE--KMLTAQDVSYDEARNLHTKWQKHQAFM 1323
Query: 1303 DSLENLMRHSEDNPNQIRILAQTLT-DGGVMDELINEELETFNSRWRELHEEAVRRQKLL 1361
L ++D +++ + LT + + L++E+L + RW EL + + L
Sbjct: 1324 AEL----AANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSL 1379
Query: 1362 ------EQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTS 1415
E QS E L +Q L D Y D + ++ Q ++ ++
Sbjct: 1380 FDANRAELFAQSCCALESWLESLQAQLHSDD-----YGKDLTSVNILLKKQQMLEWEMAV 1434
Query: 1416 HEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFE-QRLQESKMIL 1474
E +E ++ Q K AQ +V ++ + V KFR +P +RLQ S+
Sbjct: 1435 REKEVEAIQA--QAKALAQEDQGAGEV-ERTSRAVEEKFRALCQPMRERCRRLQASR--- 1488
Query: 1475 DEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS--EVEMVIKTGRQIVQKKQTE 1532
++ + H + VE E++ + + + S+ K V++++K + + ++ Q
Sbjct: 1489 EQHQFH------RDVEDEIL--WVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGH 1540
Query: 1533 NPKELDER--------------VTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNV 1578
P+ D R + L+ + LG ++ R ++LE L+ +++ ++
Sbjct: 1541 EPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALR-AQQFYRDAAE 1599
Query: 1579 LTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVL 1638
W+ ++ + + + S Q E++K +V +++ + + + +
Sbjct: 1600 AEAWMGEQELHMMGQEKAKDELS-----------AQAEVKKHQVLEQALADYAQTIHQLA 1648
Query: 1639 GKKETLVE------DKLSLLNSNWIAVTSRAEEWLNLLLE-YQKHME--TFDQNVDHITK 1689
+ +++ ++S+ + + + +E E Q+H+ + +D + +
Sbjct: 1649 ASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQ 1708
Query: 1690 WIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMAN----RGDHC 1745
WI + + + E + + +L+ E + + R +AN +AN G
Sbjct: 1709 WIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAA 1768
Query: 1746 RKLVEPQISELNHRFAAISHRIKT-GKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLK 1804
R V LN +A + + T G+ EL++F ++ L ++ + QQ +
Sbjct: 1769 RATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGT 1828
Query: 1805 EEDFNK---------DMNEDNEG---TVKELLQRGDNLQQRITDERKREEIKIKQQLLQT 1852
D N D + V+++ G LQ+ + K EEI Q +
Sbjct: 1829 GRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGD-KAEEIGRHMQAVAE 1887
Query: 1853 KHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEID 1912
L+ + RR+ L+ + + +++ + +L+ +D++ ++ + PRD +
Sbjct: 1888 AWAQLQGSSAARRQLLLDTTDK-FRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVI 1946
Query: 1913 RELQKKKEELNA 1924
+ Q K E+ A
Sbjct: 1947 KNQQGIKAEIEA 1958
Score = 107 bits (267), Expect = 2e-22
Identities = 272/1350 (20%), Positives = 535/1350 (39%), Gaps = 183/1350 (13%)
Query: 350 WLLSAEDTLQ--AQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGK 407
W+ E L A E D+EVV+ +F T E M L A V +I + +L+
Sbjct: 867 WVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAE---QLLKANP 923
Query: 408 LSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLK--ELNDWLTKTEE 465
+D QEQ LN RW+ R + K++ L L +QN L+ E W+ E
Sbjct: 924 PGKDRIVNTQEQ---LNHRWQQFRRLADGKKAALTSAL-SIQNYHLECTETQAWM---RE 976
Query: 466 RTRKMEE-EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATA- 523
+T+ +E + LG DL + ++ + DLE RV LT + ++G A A
Sbjct: 977 KTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANAL--AAGHPAQAV 1034
Query: 524 ALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHT 583
A+ +L+ + W ++ R L + + Q F AWL + AV
Sbjct: 1035 AINARLREVQTGWEDLRATMRRREESLGE-ARRLQDFLRSLDDFQAWLGRTQTAVASEEG 1093
Query: 584 TGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKS---VTQKTEAWL 640
+ E L L + A L+ ++E+ + +L +L +++ + + Q+ EA
Sbjct: 1094 PATLPEAEAL--LAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEA-- 1149
Query: 641 DNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELP 700
W+ L + E +++QA Q L E V ++++E +L + E+P
Sbjct: 1150 --LGTGWEELGRMWESRQGRLAQA-HGFQGFLRDARQAEGV--LSSQEYVL---SHTEMP 1201
Query: 701 PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF--SDLKEK 758
I + +D + +H + ++ EGN ++EK
Sbjct: 1202 GTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLV---------SEGNIHADKIREK 1252
Query: 759 VNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSER 818
++IER + +K QDA AQ + ++ + ++ E WI+ L ++
Sbjct: 1253 ADSIER----RHKKNQDA---AQQFLGRLRDNREQQHFLQDCHEL--KLWIDEKMLTAQD 1303
Query: 819 LNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSG 878
+++ E N+ + + Q ++WL E T K +LK E +L
Sbjct: 1304 VSYDE-ARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSE--KLRD 1360
Query: 879 LQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPM 938
L + + L+ + QA+ + L FD
Sbjct: 1361 LHRRWDELE-------------------------------TTTQAKARSL---FDANRAE 1386
Query: 939 RYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTT 998
+ ++ A+ +W++ + QL DY +L ++ L++QQ + ++
Sbjct: 1387 LFAQSCCALESWLESLQA-----QLHSDDYG------KDLTSVNILLKKQQMLEWEMAVR 1435
Query: 999 VKEMSK-KAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLK 1057
KE+ +A ++ + E+E + + + CQ + E+ +L+ + Q +
Sbjct: 1436 EKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHR 1495
Query: 1058 KWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEP 1117
E+ +++ E P E K L +LL+ QT+Q + ++
Sbjct: 1496 DVEDEI-LWVTERLPMASSME-HGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRA 1553
Query: 1118 EFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYL 1177
A+ EL EL W + ++ R + L+ L + +D +E WM + E +
Sbjct: 1554 LGAAAAGPELAELQEMWKRLGHELELRGKRLEDAL-RAQQFYRDAAEAEAWMGEQELHMM 1612
Query: 1178 ERDFEYKTPDELQKAVEEMK-RAKEEAQQKEAKV--KLLTESVNSVIAQAPPVAQEALKK 1234
++ K DEL E K + E+A A+ +L S + + + P + ++++
Sbjct: 1613 GQE---KAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQ 1669
Query: 1235 -ELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPG 1293
+++ L + L + + E + C +L L+ +W+ E E + + +
Sbjct: 1670 AQVDKLYAGLKELAGERRERLQ--EHLRLC--QLRRELDDLEQWIQEREV-VAASHELGQ 1724
Query: 1294 GAEEISEVLDSLENLMRHS----EDNPNQIRILAQTLTDGG-VMDELINEELETFNSRWR 1348
E ++ + D R + ++ + LA L GG + E ++ N W
Sbjct: 1725 DYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWA 1784
Query: 1349 ELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI---DKQLAAYIADKVDAAQMPQ- 1404
+L E R ++L +A E ++ LH +++L + +QL ++AA+ Q
Sbjct: 1785 DLLELLDTRGQVL----AAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQR 1840
Query: 1405 --------------EAQKIQSDLTSHEI-------SLEEMKKHNQGKEAAQRVLSQIDVA 1443
+ Q++Q D H + EE+ +H Q A L A
Sbjct: 1841 RHCAYEHDIQALSPQVQQVQDD--GHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAA 1898
Query: 1444 QKK-LQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCV 1502
+++ L D + KFR F + ++E + +DEV + + A E ++V + L
Sbjct: 1899 RRQLLLDTTDKFRFF-------KAVRELMLWMDEVNLQMDAQER---PRDVSSADL---- 1944
Query: 1503 NLYKSLSEVKSEVE-------MVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKV 1555
+ K+ +K+E+E I G++++ + +E+ E+++ L+ E K
Sbjct: 1945 -VIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYA-AEEISEKLSQLQARRQETAEKW 2002
Query: 1556 TERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQK 1615
E+ L+ L++ ++ + WL + + L + + + ++S + +A QK
Sbjct: 2003 QEKMDWLQLVLEV-LVFGRDAGMAEAWLCSQE-PLVRSAELGCTVDEVESLIKRHEAFQK 2060
Query: 1616 EI---EKQKVHLKSITEVGEALKTVLGKKE 1642
E++ L+ +T + E K K+E
Sbjct: 2061 SAVAWEERFCALEKLTALEEREKERKRKRE 2090
Score = 100 bits (250), Expect = 2e-20
Identities = 188/992 (18%), Positives = 386/992 (38%), Gaps = 116/992 (11%)
Query: 2064 PVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFL 2123
P + + E +++L+ +E + ++ R+ R + S WR F +++ W+ E + L
Sbjct: 606 PCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWR-FLWEVGEAEAWVREQQHLL 664
Query: 2124 RKTQIPENWEHA-----KYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQ 2178
+ A K+ E+ +G + + G++++ + AS
Sbjct: 665 ASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQ----GQQLVAEGHP-GASQAS 719
Query: 2179 EKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGK 2238
+ L +W+ + +R +RL + + L +FQ D N+ WL +A + S P
Sbjct: 720 ARAAELQAQWERLEALAEERAQRLAQAAS-LYQFQADANDMEAWLVDALRLVSSPELGHD 778
Query: 2239 EQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDK---LENKLKQTN 2295
E + Q + L EE+ + L L E + + +PE Q + LE ++
Sbjct: 779 EFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQ 838
Query: 2296 LQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIR-NQLEIYNQPN 2354
+ + +RAL E + + + G +E+ E+ LN L L P R LE+ Q
Sbjct: 839 ARAGERARAL-EAALALYTMLSEAGACGLWVEEKEQWLNGLAL---PERLEDLEVVQQR- 893
Query: 2355 QEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQ 2414
F+ E E+ A Q +++ Q L P + E L+ W+ RL
Sbjct: 894 ----FETLEPEMNTLAAQITAVNDIAE-QLLKANPPGKDRIVNTQEQLNHRWQQFRRL-- 946
Query: 2415 ELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRA 2474
A G K + S+L ++ +++
Sbjct: 947 ---------ADG--------------------------KKAALTSALSIQ-----NYHLE 966
Query: 2475 WTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLK 2534
TE W+ +VI+S + + DL + + K T +DLE ++ EL A L
Sbjct: 967 CTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANAL- 1025
Query: 2535 NKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQ 2594
+ I R+ +Q W++++ ++ R + L E + +L + ++ + LG+
Sbjct: 1026 -AAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGE-ARRLQDFLRSLDDFQAWLGR 1083
Query: 2595 ARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRK 2654
+ + S +EGP T+ + + + L ++ + Q+ L ++ RD +
Sbjct: 1084 TQTAVAS-EEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLF 1142
Query: 2655 VHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDA 2714
+ E + W + + R+ L + H + FL +AE + +
Sbjct: 1143 LRQRLEALGTGWEELGRMWESRQGRLAQAH--------GFQGFLRDARQAEGVLSSQEYV 1194
Query: 2715 TRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRR 2774
+ + +K+ +D ++A+ + H L E ++++ EG+ A ++ +
Sbjct: 1195 LSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVS--EGNIHADKIREK 1252
Query: 2775 LDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDF 2834
D++ + + + + L + +Q L EL +W+ K L+ Q +
Sbjct: 1253 ADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQ-DCHELKLWIDEK--MLTAQDVSYDEA 1309
Query: 2835 PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQ 2894
+ + H+AF EL + + L+K+ +E REL E+
Sbjct: 1310 RNLHTKWQKHQAFMAELAANK-------------------DWLDKVDKEGRELTLEK--P 1348
Query: 2895 NVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKG 2954
+ L+ ++ +++ W++L + R + + R + ++ L+ L +
Sbjct: 1349 ELKALVSEKLRDLHRRWDELETTTQAKARSLFDA-NRAELFAQSCCALESWLESLQAQLH 1407
Query: 2955 SWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLE 3014
S DL S+ L+K + L E+A ++ V + A+ L Q + T
Sbjct: 1408 SDDYGKDL--TSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQED-QGAGEVERTSR 1464
Query: 3015 DLNTRWKLLQVAVEDRVRQL------HEAHRD 3040
+ +++ L + +R R+L H+ HRD
Sbjct: 1465 AVEEKFRALCQPMRERCRRLQASREQHQFHRD 1496
Score = 90.9 bits (224), Expect = 2e-17
Identities = 226/1265 (17%), Positives = 480/1265 (37%), Gaps = 171/1265 (13%)
Query: 1853 KHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEID 1912
+H R+ R +ALE + Y +A +++ E+ L L P ++ +
Sbjct: 832 RHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQ 891
Query: 1913 RELQKKKEELNAVRRQAEGLSEDGAAMA---------VEPTQIQLSKRWREIESKFAQFR 1963
+ + + E+N + Q +++ + + TQ QL+ RW+ QFR
Sbjct: 892 QRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQ-------QFR 944
Query: 1964 RLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKD 2023
RL + +T + ++ Y E T + E +++ + D
Sbjct: 945 RL--------ADGKKAALTSALSIQ------NYHLECTETQAWMREKTKVIESTQGLGND 990
Query: 2024 FEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEK 2083
+ + L + L+ + R+ + +++ AL + P + V + L ++ WE
Sbjct: 991 LAGVLALQRKLAGTERDLEAIAARVGEL-TREANALAAGHPAQAVAINARLREVQTGWED 1049
Query: 2084 VNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKE 2143
+ + R+ + + + F + F WL + + + P A+
Sbjct: 1050 LRATMRRREESLGEA-RRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHA 1108
Query: 2144 -LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRL 2202
L+ + + Q+ L A GEE+ + + L+++L +L W+E+ + R+ RL
Sbjct: 1109 ALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRL 1168
Query: 2203 EEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGI 2262
Q + F RD + L + + S PG Q +++++ + +
Sbjct: 1169 -AQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGER 1227
Query: 2263 LKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQL 2322
+ L E G ++ I DK+ K + K A + G +++D +
Sbjct: 1228 IHGLLEAGRQLVSEGNI---HADKIREKADSIERRHKKNQDAAQQFLG----RLRDNREQ 1280
Query: 2323 EKKLEDLEEQLNHLLLWLSP--IRNQLEIYNQP-NQEGPFDVQETEIAVQAKQPD-VEEI 2378
+ L+D E L LW+ + Q Y++ N + + +A A D ++++
Sbjct: 1281 QHFLQDCHE----LKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKV 1336
Query: 2379 LSKGQHLYKEKPATQP-VKRKLEDLSSEWK---------------------------AVN 2410
+G+ L EKP + V KL DL W A+
Sbjct: 1337 DKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALE 1396
Query: 2411 RLLQELRAK--QPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPAL 2468
L+ L+A+ D LT++ + L Q ++ E A+ + E+ ++ + AL
Sbjct: 1397 SWLESLQAQLHSDDYGKDLTSV------NILLKKQQMLEWEMAVREKEV-EAIQAQAKAL 1449
Query: 2469 ADFNRAWTELTDWLSLLD-----------------QVIKSQRVMVGDLEDINEMIIKQKA 2511
A ++ E+ ++ Q + Q D+ED + ++
Sbjct: 1450 AQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLP 1509
Query: 2512 TMQDLEQRR--PQLEELITAAQNLKNKTSNQEARTIITDRIER---------------IQ 2554
+E + P ++ L+ Q L+ + E R I D ER +Q
Sbjct: 1510 MASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPR--IADLRERQRALGAAAAGPELAELQ 1567
Query: 2555 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 2614
W + L+ R ++L + L+ + Q+ EAE +G+ + ++ + A Q
Sbjct: 1568 EMWKRLGHELELRGKRLEDALR-AQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSA-QA 1625
Query: 2615 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 2674
++ + + L + L + + + ++ D+ ++ ++ + ++ + + +
Sbjct: 1626 EVKKHQVLEQALADYAQTIHQLAASSQDMI-DHEHPESTRISIRQAQVDKLYAGLKELAG 1684
Query: 2675 EREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQW 2734
ER L+E H L Q +L+ W+ E E A L +D + V L ++
Sbjct: 1685 ERRERLQE-HLRLCQLRRELDDLEQWIQEREVVA-------ASHELGQDYEHVTMLRDKF 1736
Query: 2735 QDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDA-VLLQRRLDNMNFKWSELRKKSLNIR 2793
++ + T +D + + G A + D++N W++L + L+ R
Sbjct: 1737 REFSR--DTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADL-LELLDTR 1793
Query: 2794 SHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKT 2853
+ A++ + +R ++ L +Q K +L G D A + H A++ +++
Sbjct: 1794 GQVLAAAYELQRFLHGARQALARVQHKQQQLPDGT--GRDLNAAEALQRRHCAYEHDIQA 1851
Query: 2854 KEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEK 2913
P + + L+K Y ++A+ + R ++ AE W +
Sbjct: 1852 LSPQVQQ---------VQDDGHRLQKAY-------AGDKAEEIGRHMQAVAE----AWAQ 1891
Query: 2914 LNLHSADWQRKIDETLER------LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSL 2967
L SA ++ + +T ++ ++EL DE++L++ E + DL+I +
Sbjct: 1892 LQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQE--RPRDVSSADLVIKNQ 1949
Query: 2968 QDHLEKVKALRGEIAPL----KENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL 3023
Q +++A + KE ++ + A +++ QL T E + L
Sbjct: 1950 QGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWL 2009
Query: 3024 QVAVE 3028
Q+ +E
Sbjct: 2010 QLVLE 2014
Score = 82.0 bits (201), Expect = 1e-14
Identities = 316/1669 (18%), Positives = 623/1669 (37%), Gaps = 262/1669 (15%)
Query: 1434 QRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEV 1493
+++ + + Q +LQ + +R +KP F ++ +++L ++ L A K
Sbjct: 331 RQLANSLSGVQNQLQSFN-SYRTVEKPPKFTEK-GNLEVLLFTIQSKLRANNQKVYTPR- 387
Query: 1494 VQSQLNHCVN-LYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELG 1552
+ +L +N ++ L + + E E+ ++T +++++++ E +L
Sbjct: 388 -EGRLISDINKAWERLEKAEHERELALRT--ELIRQEKLE-----------------QLA 427
Query: 1553 AKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKA 1612
A+ + E L ++++ + N E LAA + + K A+E V A
Sbjct: 428 ARFDRKAAMRETWLSENQRLVSQDNFGLE-LAAVEAAVRKHEAIETDIVAYSGRVQAVDA 486
Query: 1613 TQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLE 1672
E+ ++ H +K + ++ + L + V +R E L L LE
Sbjct: 487 VAAELAAERYH---------DIKRIAARQHNVAR----LWDFLRQMVAARRERLL-LNLE 532
Query: 1673 YQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK-EDVLKRLKAELNDIRPKVDSTR 1731
QK Q++ ++ W+ + L + + ED+L+ + DI + + R
Sbjct: 533 LQKVF----QDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVR 588
Query: 1732 DQAANLM--ANRGDHCR----KLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSD 1785
+A+ + N G R +LV ++++L + A+ +A LE+
Sbjct: 589 AVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRA-----RLEESRRL 643
Query: 1786 IQKLLEPLEAEI---QQGVNLKEEDFNKDMN----------------EDNEGTVKELLQR 1826
+ L E EAE +Q L D +D+ G +K L++
Sbjct: 644 WRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQ 703
Query: 1827 GDNLQQRITDERKREEIKIKQQLLQTKH-NALKDLRSQRRKKALEISHQWYQYKRQADDL 1885
G L + + + Q + AL + R+QR +A + YQ++ A+D+
Sbjct: 704 GQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASL----YQFQADANDM 759
Query: 1886 LKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQ 1945
L D + ++S DE + + R+ + +EE+ + R + L E AA+ PT
Sbjct: 760 EAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAAL--PPT- 816
Query: 1946 IQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQ 2005
R E++ + R ++ ++ E LE + T L+E
Sbjct: 817 ---LSRTPEVQGRVPTLER-HYEELQARAGERARA------LEAALALYTMLSEAGACGL 866
Query: 2006 ALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV 2065
+ E EQ LN L + EDL ++ + ++ + + +I ++ L+ A P
Sbjct: 867 WVEEKEQWLNGLAL-PERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLK-ANPP 924
Query: 2066 ERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK 2125
+ ++ QL+ +W++ ++ ++ S + +H + W+ E + +
Sbjct: 925 GKDRIVNTQEQLNHRWQQFRRLADGKKAAL-TSALSIQNYHLECTETQAWMREKTKVIES 983
Query: 2126 TQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSS------KTDASILQE 2179
TQ N + LQ + + + + A E+ ++++ A +
Sbjct: 984 TQGLGNDLAG-----VLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINA 1038
Query: 2180 KLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE 2239
+L + W+++ + R++ L E + L +F R L++F WL + P
Sbjct: 1039 RLREVQTGWEDLRATMRRREESLGEARR-LQDFLRSLDDFQAWLGRTQTAVASEEGPATL 1097
Query: 2240 QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDK----LENKLKQTN 2295
+ + L Q L E+ Q +L G ++ ++ D L +L+
Sbjct: 1098 PEAEALLAQHAALRGEVERAQSEYSRLRALG------EEVTRDQADPQCLFLRQRLEALG 1151
Query: 2296 LQWIKVSRALPEKQGEI------EAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEI 2349
W ++ R +QG + + ++D Q E L E L+H ++
Sbjct: 1152 TGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSH---------TEMPG 1202
Query: 2350 YNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKE-KPATQPVKRKLEDLSSEWK- 2407
Q +++ + A + +L G+ L E ++ K + + K
Sbjct: 1203 TLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKK 1262
Query: 2408 ---AVNRLLQELR--AKQPDLAPGLTTIGASPTQTVTLVTQPVVTKE--TAISKLEMPSS 2460
A + L LR +Q + + + L Q V E +K + +
Sbjct: 1263 NQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKM-LTAQDVSYDEARNLHTKWQKHQA 1321
Query: 2461 LMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRR 2520
M E+ A N+ W LD+V K R + + ++ ++ ++ ++DL +R
Sbjct: 1322 FMAELAA----NKDW---------LDKVDKEGRELTLEKPELKALVSEK---LRDLHRRW 1365
Query: 2521 PQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQ 2580
+LE T+ +AR++ NR + +
Sbjct: 1366 DELE-----------TTTQAKARSLFD-----------------ANRAELFAQSCCALES 1397
Query: 2581 WLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLA 2640
WLE+ QA+ + + + +V+ + KK + + +R+ + A A
Sbjct: 1398 WLESL--------QAQLHSDDYGKDLTSVNILLKK-QQMLEWEMAVREKEVEAIQAQAKA 1448
Query: 2641 LKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAW 2700
L + + R + E A + + +R +A+ E+ QF D+E + W
Sbjct: 1449 LAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQ-----HQFHRDVEDEILW 1503
Query: 2701 LTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILR 2760
+TE A+ ++ +D V+ LMK+ Q LQ EI+ H +L E Q+ L
Sbjct: 1504 VTERLPMASSMEHG-------KDLPSVQLLMKKNQTLQKEIQGHEPRIADLRER-QRALG 1555
Query: 2761 SLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLE------ASSDQW---KRLHLSLQ 2811
+ + LQ + + ELR K L + A ++ W + LH+ Q
Sbjct: 1556 AAAAGPELAELQEMWKRLGHE-LELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQ 1614
Query: 2812 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVI-MSTLETVRIFLT 2870
E DELS QA + Q D + + + + +I E+ RI +
Sbjct: 1615 E------KAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIR 1668
Query: 2871 EQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLE 2930
+ ++KLY +EL E R E+L H
Sbjct: 1669 QAQ---VDKLYAGLKELAGERR-------------------ERLQEHL------------ 1694
Query: 2931 RLQELQEATDELDLKLRQAEVIKGSWQPVGDL-LIDSLQDHLEKVKALRGEIAPLKENVS 2989
RL +L+ D+L+ +++ EV+ S + D + L+D + I +E V
Sbjct: 1695 RLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIG--QERVD 1752
Query: 2990 HVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAH 3038
N LA L G + LN W L ++ R + L A+
Sbjct: 1753 SANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAY 1801
Score = 41.6 bits (96), Expect = 0.015
Identities = 96/537 (17%), Positives = 204/537 (37%), Gaps = 60/537 (11%)
Query: 2514 QDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNE 2573
+D+ +P + +IT + S +A + RI ++ + E + ++ +E
Sbjct: 257 EDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASE 316
Query: 2574 MLKDSTQWLEAK------EEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLR 2627
+L QW+E + L + +L+S+ Y K TE L L
Sbjct: 317 LL----QWIEQTIVTLNDRQLANSLSGVQNQLQSFNS--YRTVEKPPKFTEKGNLEVLLF 370
Query: 2628 QWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAAL------- 2680
Q+ + N + Y+ + R + +IN +W + K ERE AL
Sbjct: 371 TIQSKLRANNQ------KVYTPREGRLI----SDINKAWERLEKAEHERELALRTELIRQ 420
Query: 2681 EETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGE 2740
E+ +L +F WL+E Q ++ + V+ +++ + ++ +
Sbjct: 421 EKLEQLAARFDRKAAMRETWLSEN-------QRLVSQDNFGLELAAVEAAVRKHEAIETD 473
Query: 2741 IEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASS 2800
I A++ +D + ++ + E D + R N+ W LR+ R L +
Sbjct: 474 IVAYSGRVQAVDAVAAEL--AAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNL 531
Query: 2801 DQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMS 2860
+ +++ L L+ W++ L Q +G V+ +H + ++ + + +
Sbjct: 532 -ELQKVFQDLLYLMDWMEEMKGRLQSQ-DLGRHLAGVEDLLQLHELVEADIAVQAERVRA 589
Query: 2861 TLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSAD 2920
+ F P +E +L+ ++ ++ +E L +A
Sbjct: 590 VSASALRFCN-----------------PGKEYRPCDPQLVSERVAKLEQSYEALCELAAA 632
Query: 2921 WQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGE 2980
+ +++E+ RL E + +R+ + + S DL L K ALRGE
Sbjct: 633 RRARLEES-RRLWRFLWEVGEAEAWVREQQHLLASADTGRDL--TGALRLLNKHTALRGE 689
Query: 2981 IAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEA 3037
++ + + +QL G + + +L +W+ L+ E+R ++L +A
Sbjct: 690 MSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQA 746
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 134,523,769
Number of Sequences: 37866
Number of extensions: 6160121
Number of successful extensions: 42310
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 184
Number of HSP's successfully gapped in prelim test: 1071
Number of HSP's that attempted gapping in prelim test: 23179
Number of HSP's gapped (non-prelim): 11017
length of query: 3681
length of database: 18,247,518
effective HSP length: 122
effective length of query: 3559
effective length of database: 13,627,866
effective search space: 48501575094
effective search space used: 48501575094
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 72 (32.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.