Search of human proteins with 5031973

Search of human proteins with 5031973

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5031973 protein disulfide isomerase A6 [Homo sapiens]
         (440 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5031973 protein disulfide isomerase A6 [Homo sapiens]              892   0.0  
gi|4758304 protein disulfide isomerase A4 [Homo sapiens]              161   1e-39
gi|42794771 thioredoxin domain containing 5 isoform 1 precursor ...   145   5e-35
gi|224493972 thioredoxin domain containing 5 isoform 3 [Homo sap...   145   5e-35
gi|24308127 DnaJ (Hsp40) homolog, subfamily C, member 10 [Homo s...   133   4e-31
gi|5803121 protein disulfide isomerase A5 [Homo sapiens]              124   2e-28
gi|21361657 protein disulfide-isomerase A3 precursor [Homo sapiens]   110   3e-24
gi|38505222 thioredoxin domain containing 10 [Homo sapiens]            98   1e-20
gi|20070125 prolyl 4-hydroxylase, beta subunit precursor [Homo s...    98   1e-20
gi|94966757 protein disulfide isomerase A2 [Homo sapiens]              79   6e-15
gi|151101292 thioredoxin domain containing 1 [Homo sapiens]            67   2e-11
gi|145580631 quiescin Q6 sulfhydryl oxidase 2 [Homo sapiens]           64   4e-10
gi|51873067 quiescin Q6 sulfhydryl oxidase 1 isoform b [Homo sap...    62   1e-09
gi|13325075 quiescin Q6 sulfhydryl oxidase 1 isoform a [Homo sap...    62   1e-09
gi|52487191 thioredoxin domain containing 4 (endoplasmic reticul...    61   2e-09
gi|21361403 thioredoxin 2 precursor [Homo sapiens]                     49   1e-05
gi|40254947 thioredoxin-related transmembrane protein 4 [Homo sa...    45   1e-04
gi|237648961 thioredoxin domain containing 16 isoform 2 [Homo sa...    43   6e-04
gi|237648959 thioredoxin domain containing 16 isoform 1 [Homo sa...    43   6e-04
gi|54633317 thioredoxin domain containing 11 [Homo sapiens]            42   0.001
gi|50592994 thioredoxin [Homo sapiens]                                 40   0.004
gi|94421469 disulfide isomerase [Homo sapiens]                         39   0.009
gi|28372543 protein disulfide isomerase-like, testis expressed [...    38   0.016
gi|56687498 DnaJ (Hsp40) homolog, subfamily C, member 16 [Homo s...    36   0.079
gi|95113651 glutaredoxin 3 [Homo sapiens]                              35   0.14 
gi|221136993 thioredoxin domain containing 14 isoform 2 [Homo sa...    34   0.30 
gi|7705726 thioredoxin domain containing 14 isoform 1 [Homo sapi...    34   0.30 
gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo sap...    33   0.39 
gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo sap...    33   0.39 
gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo sapi...    33   0.39 

>gi|5031973 protein disulfide isomerase A6 [Homo sapiens]
          Length = 440

 Score =  892 bits (2306), Expect = 0.0
 Identities = 440/440 (100%), Positives = 440/440 (100%)

Query: 1   MALLVLGLVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQR 60
           MALLVLGLVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQR
Sbjct: 1   MALLVLGLVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQR 60

Query: 61  LTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTG 120
           LTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTG
Sbjct: 61  LTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTG 120

Query: 121 EAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDV 180
           EAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDV
Sbjct: 121 EAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDV 180

Query: 181 WMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTI 240
           WMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTI
Sbjct: 181 WMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTI 240

Query: 241 KIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVA 300
           KIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVA
Sbjct: 241 KIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVA 300

Query: 301 VLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMA 360
           VLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMA
Sbjct: 301 VLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMA 360

Query: 361 AINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTIVEREPWDGRDGELP 420
           AINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTIVEREPWDGRDGELP
Sbjct: 361 AINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTIVEREPWDGRDGELP 420

Query: 421 VEDDIDLSDVELDDLGKDEL 440
           VEDDIDLSDVELDDLGKDEL
Sbjct: 421 VEDDIDLSDVELDDLGKDEL 440


>gi|4758304 protein disulfide isomerase A4 [Homo sapiens]
          Length = 645

 Score =  161 bits (408), Expect = 1e-39
 Identities = 99/259 (38%), Positives = 147/259 (56%), Gaps = 33/259 (12%)

Query: 27  VIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDV---VKVGAVDA 83
           V+ L  +NF+  V   D++ L+EFYAPWCGHC++  PE++K A  LKD    + V  +DA
Sbjct: 64  VLVLNDANFDNFVADKDTV-LLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDA 122

Query: 84  DKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRS 143
                L  ++ V G+PTIKI    K +  DY+G RT E IV    + +R++         
Sbjct: 123 TSASVLASRFDVSGYPTIKIL--KKGQAVDYEGSRTQEEIV----AKVREV--------- 167

Query: 144 GGYSSGKQGRSDSSSKKDV-IELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAA 202
                    + D +   +V + LT ++FD+ V D+ D+ +VEFYAPWCGHCK L PE+  
Sbjct: 168 --------SQPDWTPPPEVTLVLTKENFDEVVNDA-DIILVEFYAPWCGHCKKLAPEYEK 218

Query: 203 AASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIV 262
           AA E+ +++   + LA VDAT    LA R+ + G+PT+KIF+KG  P DY+G R +  IV
Sbjct: 219 AAKELSKRSP-PIPLAKVDATAETDLAKRFDVSGYPTLKIFRKGR-PYDYNGPREKYGIV 276

Query: 263 SRALDLFSDNAPPPELLEI 281
              ++      P  E+L +
Sbjct: 277 DYMIE--QSGPPSKEILTL 293



 Score =  105 bits (261), Expect = 1e-22
 Identities = 53/125 (42%), Positives = 84/125 (67%), Gaps = 4/125 (3%)

Query: 162 VIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVD 221
           V+ L D +FD  V D + V ++EFYAPWCGHCK   PE+   A+ +K++    + +A +D
Sbjct: 64  VLVLNDANFDNFVADKDTV-LLEFYAPWCGHCKQFAPEYEKIANILKDKDP-PIPVAKID 121

Query: 222 ATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFS-DNAPPPELLE 280
           AT   VLASR+ + G+PTIKI +KG++ VDY+G RT+ +IV++  ++   D  PPPE+  
Sbjct: 122 ATSASVLASRFDVSGYPTIKILKKGQA-VDYEGSRTQEEIVAKVREVSQPDWTPPPEVTL 180

Query: 281 IINED 285
           ++ ++
Sbjct: 181 VLTKE 185



 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 45/113 (39%), Positives = 69/113 (61%), Gaps = 4/113 (3%)

Query: 157 SSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVK 216
           ++K  V  +   +FD  V+D +   ++EFYAPWCGHCK LEP + + A + K Q KG V 
Sbjct: 522 NNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQ-KGLV- 579

Query: 217 LAAVDATVNQVLASRYGIRGFPTIKIFQKGE--SPVDYDGGRTRSDIVSRALD 267
           +A +DAT N V + RY + GFPTI     G+  +PV ++GG    + +S+ ++
Sbjct: 580 IAKMDATANDVPSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIE 632



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 29/74 (39%), Positives = 42/74 (56%), Gaps = 3/74 (4%)

Query: 47  LVEFYAPWCGHCQRLTPEWKKAATALKDV--VKVGAVDADKHHSLGGQYGVQGFPTIKIF 104
           L+EFYAPWCGHC++L P +   A   K    + +  +DA  +     +Y V+GFPTI   
Sbjct: 547 LIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIYFA 606

Query: 105 GS-NKNRPEDYQGG 117
            S +K  P  ++GG
Sbjct: 607 PSGDKKNPVKFEGG 620


>gi|42794771 thioredoxin domain containing 5 isoform 1 precursor
           [Homo sapiens]
          Length = 432

 Score =  145 bits (367), Expect = 5e-35
 Identities = 81/237 (34%), Positives = 128/237 (54%), Gaps = 23/237 (9%)

Query: 29  ELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALK--DVVKVGAVDADKH 86
           EL+ SNF   V Q D    ++F+APWCGHC+ L P W++ A  L+  + VK+G VD  +H
Sbjct: 193 ELSASNFELHVAQGDHF--IKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQH 250

Query: 87  HSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGY 146
           + L     V+G+PT+  F   K + + Y+G R         L +LR+ V+ +L     G 
Sbjct: 251 YELCSGNQVRGYPTLLWFRDGK-KVDQYKGKRD--------LESLREYVESQLQRTETGA 301

Query: 147 SSGKQ-------GRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPE 199
           +                + K  V+ LT+++FD  +  +E +  ++FYAPWCGHCK L P 
Sbjct: 302 TETVTPSEAPVLAAEPEADKGTVLALTENNFDDTI--AEGITFIKFYAPWCGHCKTLAPT 359

Query: 200 WAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGR 256
           W   + +      G VK+A VD T  + + S+Y +RG+PT+ +F+ G+   ++ GGR
Sbjct: 360 WEELSKKEFPGLAG-VKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGR 415



 Score =  109 bits (272), Expect = 6e-24
 Identities = 68/213 (31%), Positives = 103/213 (48%), Gaps = 17/213 (7%)

Query: 48  VEFYAPWCGHCQRLTPEWKKAA---TALKDV-VKVGAVDADKHHSLGGQYGVQGFPTIKI 103
           V F+APWCGHCQRL P W        +++D  V V  VD   H  +    GV+G+PT+K+
Sbjct: 82  VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141

Query: 104 FGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVI 163
           F   +   + YQG R  + + +  L  L +                 +  S    K+ + 
Sbjct: 142 FKPGQEAVK-YQGPRDFQTLENWMLQTLNE--------EPVTPEPEVEPPSAPELKQGLY 192

Query: 164 ELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDAT 223
           EL+  +F+ +V   +    ++F+APWCGHCK L P W   A  ++      VK+  VD T
Sbjct: 193 ELSASNFELHVAQGDH--FIKFFAPWCGHCKALAPTWEQLALGLEHSE--TVKIGKVDCT 248

Query: 224 VNQVLASRYGIRGFPTIKIFQKGESPVDYDGGR 256
            +  L S   +RG+PT+  F+ G+    Y G R
Sbjct: 249 QHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKR 281



 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 34/95 (35%), Positives = 51/95 (53%)

Query: 183 VEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKI 242
           V F+APWCGHC+ L+P W     +       KV +A VD T +  + S  G+RG+PT+K+
Sbjct: 82  VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141

Query: 243 FQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPE 277
           F+ G+  V Y G R    + +  L   ++    PE
Sbjct: 142 FKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPE 176


>gi|224493972 thioredoxin domain containing 5 isoform 3 [Homo
           sapiens]
          Length = 324

 Score =  145 bits (367), Expect = 5e-35
 Identities = 81/237 (34%), Positives = 128/237 (54%), Gaps = 23/237 (9%)

Query: 29  ELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALK--DVVKVGAVDADKH 86
           EL+ SNF   V Q D    ++F+APWCGHC+ L P W++ A  L+  + VK+G VD  +H
Sbjct: 85  ELSASNFELHVAQGDHF--IKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQH 142

Query: 87  HSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGY 146
           + L     V+G+PT+  F   K + + Y+G R         L +LR+ V+ +L     G 
Sbjct: 143 YELCSGNQVRGYPTLLWFRDGK-KVDQYKGKRD--------LESLREYVESQLQRTETGA 193

Query: 147 SSGKQ-------GRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPE 199
           +                + K  V+ LT+++FD  +  +E +  ++FYAPWCGHCK L P 
Sbjct: 194 TETVTPSEAPVLAAEPEADKGTVLALTENNFDDTI--AEGITFIKFYAPWCGHCKTLAPT 251

Query: 200 WAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGR 256
           W   + +      G VK+A VD T  + + S+Y +RG+PT+ +F+ G+   ++ GGR
Sbjct: 252 WEELSKKEFPGLAG-VKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGR 307



 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 53/181 (29%), Positives = 84/181 (46%), Gaps = 13/181 (7%)

Query: 76  VKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLV 135
           V V  VD   H  +    GV+G+PT+K+F   +   + YQG R  + + +  L  L +  
Sbjct: 6   VYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVK-YQGPRDFQTLENWMLQTLNE-- 62

Query: 136 KDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKN 195
                          +  S    K+ + EL+  +F+ +V   +    ++F+APWCGHCK 
Sbjct: 63  ------EPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDH--FIKFFAPWCGHCKA 114

Query: 196 LEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGG 255
           L P W   A  ++      VK+  VD T +  L S   +RG+PT+  F+ G+    Y G 
Sbjct: 115 LAPTWEQLALGLEHSE--TVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGK 172

Query: 256 R 256
           R
Sbjct: 173 R 173



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 22/64 (34%), Positives = 35/64 (54%)

Query: 214 KVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNA 273
           KV +A VD T +  + S  G+RG+PT+K+F+ G+  V Y G R    + +  L   ++  
Sbjct: 5   KVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNEEP 64

Query: 274 PPPE 277
             PE
Sbjct: 65  VTPE 68


>gi|24308127 DnaJ (Hsp40) homolog, subfamily C, member 10 [Homo
           sapiens]
          Length = 793

 Score =  133 bits (334), Expect = 4e-31
 Identities = 73/219 (33%), Positives = 107/219 (48%), Gaps = 29/219 (13%)

Query: 27  VIELTPSNFNREVIQS--DSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDAD 84
           V+ LTP+ FN  V Q   + +W+V+FY+PWC  CQ L PEWK+ A  L  ++ VG++D  
Sbjct: 558 VVSLTPTTFNELVTQRKHNEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGLINVGSIDCQ 617

Query: 85  KHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSG 144
           ++HS   Q  VQ +P I+ F    N+   Y               +     +D    R  
Sbjct: 618 QYHSFCAQENVQRYPEIRFFPPKSNKAYHYH--------------SYNGWNRDAYSLRIW 663

Query: 145 GYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAA 204
           G     Q  +D         LT  +F + VL  ++ W+++FYAPWCG C+N  PE+   A
Sbjct: 664 GLGFLPQVSTD---------LTPQTFSEKVLQGKNHWVIDFYAPWCGPCQNFAPEFELLA 714

Query: 205 SEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIF 243
             +    KGKVK   VD         + GIR +PT+K +
Sbjct: 715 RMI----KGKVKAGKVDCQAYAQTCQKAGIRAYPTVKFY 749



 Score =  102 bits (254), Expect = 7e-22
 Identities = 61/224 (27%), Positives = 103/224 (45%), Gaps = 38/224 (16%)

Query: 22  SSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAV 81
           S +  V  L P NF          WLV+F+APWC  C+ L PE ++A+  L   +K G +
Sbjct: 450 SVNSHVTTLGPQNFPAN---DKEPWLVDFFAPWCPPCRALLPELRRASNLLYGQLKFGTL 506

Query: 82  DADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGG 141
           D   H  L   Y +Q +PT  +F  N++   +Y+G  + E I++         ++D +  
Sbjct: 507 DCTVHEGLCNMYNIQAYPTTVVF--NQSNIHEYEGHHSAEQILE--------FIEDLMN- 555

Query: 142 RSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSE--DVWMVEFYAPWCGHCKNLEPE 199
                               V+ LT  +F++ V   +  +VWMV+FY+PWC  C+ L PE
Sbjct: 556 ------------------PSVVSLTPTTFNELVTQRKHNEVWMVDFYSPWCHPCQVLMPE 597

Query: 200 WAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIF 243
           W   A  +     G + + ++D        ++  ++ +P I+ F
Sbjct: 598 WKRMARTL----TGLINVGSIDCQQYHSFCAQENVQRYPEIRFF 637



 Score = 75.9 bits (185), Expect = 7e-14
 Identities = 34/98 (34%), Positives = 56/98 (57%), Gaps = 3/98 (3%)

Query: 29  ELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHS 88
           +LTP  F+ +V+Q  + W+++FYAPWCG CQ   PE++  A  +K  VK G VD   +  
Sbjct: 674 DLTPQTFSEKVLQGKNHWVIDFYAPWCGPCQNFAPEFELLARMIKGKVKAGKVDCQAYAQ 733

Query: 89  LGGQYGVQGFPTIKIF---GSNKNRPEDYQGGRTGEAI 123
              + G++ +PT+K +    + +N  E+    R  +AI
Sbjct: 734 TCQKAGIRAYPTVKFYFYERAKRNFQEEQINTRDAKAI 771



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 40/132 (30%), Positives = 70/132 (53%), Gaps = 5/132 (3%)

Query: 135 VKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCK 194
           ++D  GG+   ++  +          ++I L    FD  V +S ++W V FY+P C HC 
Sbjct: 104 LEDNQGGQYESWNYYRYDFGIYDDDPEIITLERREFDAAV-NSGELWFVNFYSPGCSHCH 162

Query: 195 NLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDG 254
           +L P W   A EV     G +++ AV+   +++L    G+  +P++ IF+ G +PV Y G
Sbjct: 163 DLAPTWRDFAKEV----DGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMAPVKYHG 218

Query: 255 GRTRSDIVSRAL 266
            R++  +VS A+
Sbjct: 219 DRSKESLVSFAM 230



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 39/119 (32%), Positives = 60/119 (50%), Gaps = 2/119 (1%)

Query: 19  GLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKV 78
           G+Y    ++I L    F+  V  S  LW V FY+P C HC  L P W+  A  +  ++++
Sbjct: 123 GIYDDDPEIITLERREFDAAV-NSGELWFVNFYSPGCSHCHDLAPTWRDFAKEVDGLLRI 181

Query: 79  GAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKD 137
           GAV+      L    GV  +P++ IF S    P  Y G R+ E++V  A+  +R  V +
Sbjct: 182 GAVNCGDDRMLCRMKGVNSYPSLFIFRSGM-APVKYHGDRSKESLVSFAMQHVRSTVTE 239



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 28/95 (29%), Positives = 53/95 (55%), Gaps = 5/95 (5%)

Query: 176 DSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIR 235
           + ++ W+V+F+APWC  C+ L PE   A++ +     G++K   +D TV++ L + Y I+
Sbjct: 466 NDKEPWLVDFFAPWCPPCRALLPELRRASNLLY----GQLKFGTLDCTVHEGLCNMYNIQ 521

Query: 236 GFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFS 270
            +PT  +F +     +Y+G  +   I+    DL +
Sbjct: 522 AYPTTVVFNQSNIH-EYEGHHSAEQILEFIEDLMN 555


>gi|5803121 protein disulfide isomerase A5 [Homo sapiens]
          Length = 519

 Score =  124 bits (310), Expect = 2e-28
 Identities = 78/227 (34%), Positives = 119/227 (52%), Gaps = 21/227 (9%)

Query: 26  DVIEL-TPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVD-- 82
           DV+ L +  +F R + + +   L+ FYAPWC  C+R+ P ++KAAT L+    +  ++  
Sbjct: 152 DVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKAATQLRGHAVLAGMNVY 211

Query: 83  ADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSAL--RQLVKDRLG 140
           + +  ++  +Y V+GFPTI  F   +   +    G T E IV+   +    +  V +   
Sbjct: 212 SSEFENIKEEYSVRGFPTICYFEKGRFLFQYDNYGSTAEDIVEWLKNPQPPQPQVPETPW 271

Query: 141 GRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEW 200
              GG                V  LTD+ FD+ V +   V +V F+APWCGHCK ++PE+
Sbjct: 272 ADEGG---------------SVYHLTDEDFDQFVKEHSSV-LVMFHAPWCGHCKKMKPEF 315

Query: 201 AAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGE 247
             AA  +  +      LAAVDATVN+ LA R+ I  FPT+K F+ GE
Sbjct: 316 EKAAEALHGEADSSGVLAAVDATVNKALAERFHISEFPTLKYFKNGE 362



 Score =  103 bits (257), Expect = 3e-22
 Identities = 72/237 (30%), Positives = 112/237 (47%), Gaps = 27/237 (11%)

Query: 27  VIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVK----VGAVD 82
           V  LT  +F++ V +  S+ LV F+APWCGHC+++ PE++KAA AL         + AVD
Sbjct: 278 VYHLTDEDFDQFVKEHSSV-LVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVD 336

Query: 83  ADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGR 142
           A  + +L  ++ +  FPT+K F             + GE      L   ++ ++      
Sbjct: 337 ATVNKALAERFHISEFPTLKYF-------------KNGEKYAVPVLRTKKKFLEWMQNPE 383

Query: 143 SGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAA 202
           +            +S    V+ L  D+F +  L  +   +V FYAPWC HCK + P + A
Sbjct: 384 APPPPEPTWEEQQTS----VLHLVGDNF-RETLKKKKHTLVMFYAPWCPHCKKVIPHFTA 438

Query: 203 AASEVKEQTKGKVKLAAVDAT--VNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRT 257
            A   K+    K+  AAVD     NQ L  +  ++G+PT   +  G+    YD  RT
Sbjct: 439 TADAFKDDR--KIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDRT 493



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 41/122 (33%), Positives = 61/122 (50%), Gaps = 13/122 (10%)

Query: 160 KDVIELTDDSFDKNVLDSEDV-WMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLA 218
           KDV+ L  +   + +L  E+   ++ FYAPWC  CK + P +  AA+    Q +G   LA
Sbjct: 151 KDVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKAAT----QLRGHAVLA 206

Query: 219 AVDATVNQV--LASRYGIRGFPTIKIFQKGESPVDYDG-GRTRSDIVSRALDLFSDNAPP 275
            ++   ++   +   Y +RGFPTI  F+KG     YD  G T  DIV      +  N  P
Sbjct: 207 GMNVYSSEFENIKEEYSVRGFPTICYFEKGRFLFQYDNYGSTAEDIVE-----WLKNPQP 261

Query: 276 PE 277
           P+
Sbjct: 262 PQ 263



 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 45/118 (38%), Positives = 60/118 (50%), Gaps = 7/118 (5%)

Query: 27  VIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKV--GAVDA- 83
           V+ L   NF RE ++     LV FYAPWC HC+++ P +   A A KD  K+   AVD  
Sbjct: 399 VLHLVGDNF-RETLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKDDRKIACAAVDCV 457

Query: 84  -DKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLG 140
            DK+  L  Q  V+G+PT   +   K   E Y   RT E      + ALR+   +RLG
Sbjct: 458 KDKNQDLCQQEAVKGYPTFHYYHYGK-FAEKYDSDRT-ELGFTNYIRALREGDHERLG 513


>gi|21361657 protein disulfide-isomerase A3 precursor [Homo sapiens]
          Length = 505

 Score =  110 bits (275), Expect = 3e-24
 Identities = 63/174 (36%), Positives = 93/174 (53%), Gaps = 14/174 (8%)

Query: 157 SSKKDVIELTDDSFDKNVLD--SEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGK 214
           ++  DV+ELTDD+F+  + D  S  + +VEF+APWCGHCK L PE+ AAA+ +K    G 
Sbjct: 22  AAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLK----GI 77

Query: 215 VKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAP 274
           V LA VD T N    ++YG+ G+PT+KIF+ GE    YDG RT   IVS           
Sbjct: 78  VPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHL-----KKQA 132

Query: 275 PPELLEIINEDIAKRTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYK 328
            P  + +  E+  K+   +    +V       D+ +   + +L+    L D Y+
Sbjct: 133 GPASVPLRTEEEFKKFISDKDASIVGFFD---DSFSEAHSEFLKAASNLRDNYR 183



 Score = 95.9 bits (237), Expect = 6e-20
 Identities = 61/175 (34%), Positives = 89/175 (50%), Gaps = 12/175 (6%)

Query: 1   MALLVLGLVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDS--LWLVEFYAPWCGHC 58
           M L  L L      L      +++ DV+ELT  NF   +  + S  L LVEF+APWCGHC
Sbjct: 1   MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHC 60

Query: 59  QRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGR 118
           +RL PE++ AAT LK +V +  VD   + +   +YGV G+PT+KIF   +     Y G R
Sbjct: 61  KRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGA-YDGPR 119

Query: 119 TGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSK-KDVIELTDDSFDK 172
           T + IV          +K + G  S    + ++ +   S K   ++   DDSF +
Sbjct: 120 TADGIVSH--------LKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSE 166



 Score = 79.3 bits (194), Expect = 6e-15
 Identities = 49/136 (36%), Positives = 72/136 (52%), Gaps = 7/136 (5%)

Query: 130 ALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPW 189
           AL + ++D   G    Y   K      S+   V  +  ++FD+ V +     ++EFYAPW
Sbjct: 348 ALERFLQDYFDGNLKRYL--KSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPW 405

Query: 190 CGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKI--FQKGE 247
           CGHCKNLEP++     ++ +     + +A +DAT N V  S Y +RGFPTI      K  
Sbjct: 406 CGHCKNLEPKYKELGEKLSKDP--NIVIAKMDATANDV-PSPYEVRGFPTIYFSPANKKL 462

Query: 248 SPVDYDGGRTRSDIVS 263
           +P  Y+GGR  SD +S
Sbjct: 463 NPKKYEGGRELSDFIS 478



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 38/100 (38%), Positives = 56/100 (56%), Gaps = 4/100 (4%)

Query: 22  SSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATAL-KDV-VKVG 79
           S+   V  +   NF+  V   +   L+EFYAPWCGHC+ L P++K+    L KD  + + 
Sbjct: 373 SNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIA 432

Query: 80  AVDADKHHSLGGQYGVQGFPTIKIFGSNKN-RPEDYQGGR 118
            +DA   + +   Y V+GFPTI    +NK   P+ Y+GGR
Sbjct: 433 KMDATA-NDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGR 471


>gi|38505222 thioredoxin domain containing 10 [Homo sapiens]
          Length = 454

 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 48/106 (45%), Positives = 68/106 (64%), Gaps = 4/106 (3%)

Query: 160 KDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAA 219
           K  +E  D+SF +N   ++D+W+V+FYAPWCGHCK LEP W     E+K      VK+  
Sbjct: 25  KGFVEDLDESFKEN--RNDDIWLVDFYAPWCGHCKKLEPIWNEVGLEMK-SIGSPVKVGK 81

Query: 220 VDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRA 265
           +DAT    +AS +G+RG+PTIK+  KG+   +Y G RT+ DI+  A
Sbjct: 82  MDATSYSSIASEFGVRGYPTIKLL-KGDLAYNYRGPRTKDDIIEFA 126



 Score = 85.9 bits (211), Expect = 7e-17
 Identities = 46/128 (35%), Positives = 73/128 (57%), Gaps = 20/128 (15%)

Query: 3   LLVLGLVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLT 62
           ++VL +V C  F+         +D+ E    N N      D +WLV+FYAPWCGHC++L 
Sbjct: 16  VVVLDMVVCKGFV---------EDLDESFKENRN------DDIWLVDFYAPWCGHCKKLE 60

Query: 63  PEWKKAATALKDV---VKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRT 119
           P W +    +K +   VKVG +DA  + S+  ++GV+G+PTIK+     +   +Y+G RT
Sbjct: 61  PIWNEVGLEMKSIGSPVKVGKMDATSYSSIASEFGVRGYPTIKLL--KGDLAYNYRGPRT 118

Query: 120 GEAIVDAA 127
            + I++ A
Sbjct: 119 KDDIIEFA 126


>gi|20070125 prolyl 4-hydroxylase, beta subunit precursor [Homo
           sapiens]
          Length = 508

 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 50/113 (44%), Positives = 72/113 (63%), Gaps = 3/113 (2%)

Query: 153 RSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTK 212
           R+D+  ++D + +   S     L +    +VEFYAPWCGHCK L PE+A AA ++K +  
Sbjct: 16  RADAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAE-G 74

Query: 213 GKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGE--SPVDYDGGRTRSDIVS 263
            +++LA VDAT    LA +YG+RG+PTIK F+ G+  SP +Y  GR   DIV+
Sbjct: 75  SEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVN 127



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 47/105 (44%), Positives = 63/105 (60%), Gaps = 5/105 (4%)

Query: 25  DDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALK---DVVKVGAV 81
           D V+ L  SNF  E + +    LVEFYAPWCGHC+ L PE+ KAA  LK     +++  V
Sbjct: 24  DHVLVLRKSNF-AEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEIRLAKV 82

Query: 82  DADKHHSLGGQYGVQGFPTIKIF-GSNKNRPEDYQGGRTGEAIVD 125
           DA +   L  QYGV+G+PTIK F   +   P++Y  GR  + IV+
Sbjct: 83  DATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVN 127



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 37/101 (36%), Positives = 53/101 (52%), Gaps = 6/101 (5%)

Query: 159 KKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLA 218
           K+ V  L   +F+    D +    VEFYAPWCGHCK L P W       K+     + +A
Sbjct: 366 KQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHE--NIVIA 423

Query: 219 AVDATVNQVLASRYGIRGFPTIKIF--QKGESPVDYDGGRT 257
            +D+T N+V A +  +  FPT+K F      + +DY+G RT
Sbjct: 424 KMDSTANEVEAVK--VHSFPTLKFFPASADRTVIDYNGERT 462



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 40/145 (27%), Positives = 59/145 (40%), Gaps = 19/145 (13%)

Query: 30  LTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSL 89
           L   NF            VEFYAPWCGHC++L P W K     KD   +     D   + 
Sbjct: 372 LVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANE 431

Query: 90  GGQYGVQGFPTIKIFGSNKNRPE-DYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSS 148
                V  FPT+K F ++ +R   DY G RT        L   ++ ++          S 
Sbjct: 432 VEAVKVHSFPTLKFFPASADRTVIDYNGERT--------LDGFKKFLE----------SG 473

Query: 149 GKQGRSDSSSKKDVIELTDDSFDKN 173
           G+ G  D    +D+ E  +   +++
Sbjct: 474 GQDGAGDDDDLEDLEEAEEPDMEED 498


>gi|94966757 protein disulfide isomerase A2 [Homo sapiens]
          Length = 525

 Score = 79.3 bits (194), Expect = 6e-15
 Identities = 39/83 (46%), Positives = 48/83 (57%), Gaps = 4/83 (4%)

Query: 47  LVEFYAPWCGHCQRLTPEWKKAATAL---KDVVKVGAVDADKHHSLGGQYGVQGFPTIKI 103
           LVEFYAPWCGHCQ L PE+ KAA  L     VV +  VD      L  ++GV  +PT+K 
Sbjct: 63  LVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKF 122

Query: 104 F-GSNKNRPEDYQGGRTGEAIVD 125
           F   N+  PE+Y G R  E I +
Sbjct: 123 FRNGNRTHPEEYTGPRDAEGIAE 145



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 41/124 (33%), Positives = 61/124 (49%), Gaps = 3/124 (2%)

Query: 140 GGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPE 199
           G   G  S  ++   +   K+D I +         L      +VEFYAPWCGHC+ L PE
Sbjct: 21  GQEQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPE 80

Query: 200 WAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGE--SPVDYDGGRT 257
           ++ AA+ +  ++   V LA VD    + LA  +G+  +PT+K F+ G    P +Y G R 
Sbjct: 81  YSKAAAVLAAESM-VVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRD 139

Query: 258 RSDI 261
              I
Sbjct: 140 AEGI 143



 Score = 65.5 bits (158), Expect = 9e-11
 Identities = 61/207 (29%), Positives = 92/207 (44%), Gaps = 26/207 (12%)

Query: 81  VDADKHHSLGGQY---GVQGFPTIKIFG---SNKNRPEDYQGGRTGEAIVDAALSALRQL 134
           V AD  H L  QY     +  PT+++     + K  P D      G  +  A+++A    
Sbjct: 315 VAADNEHVL--QYFGLKAEAAPTLRLVNLETTKKYAPVD------GGPVTAASITAFCHA 366

Query: 135 VKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCK 194
           V   L G+   Y   ++   D   ++ V  L   +F++   D      V+FYAPWC HCK
Sbjct: 367 V---LNGQVKPYLLSQEIPPDWD-QRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCK 422

Query: 195 NLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDG 254
            + P W A A   K Q    + +A +DAT N++ A  + + GFPT+K F  G      + 
Sbjct: 423 EMAPAWEALAE--KYQDHEDIIIAELDATANELDA--FAVHGFPTLKYFPAGPGRKVIEY 478

Query: 255 GRTRS-DIVSRALD---LFSDNAPPPE 277
             TR  +  S+ LD   +     PP E
Sbjct: 479 KSTRDLETFSKFLDNGGVLPTEEPPEE 505



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 25/81 (30%), Positives = 37/81 (45%)

Query: 30  LTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSL 89
           L   NF +          V+FYAPWC HC+ + P W+  A   +D   +   + D   + 
Sbjct: 393 LVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDATANE 452

Query: 90  GGQYGVQGFPTIKIFGSNKNR 110
              + V GFPT+K F +   R
Sbjct: 453 LDAFAVHGFPTLKYFPAGPGR 473


>gi|151101292 thioredoxin domain containing 1 [Homo sapiens]
          Length = 280

 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 38/105 (36%), Positives = 62/105 (59%), Gaps = 7/105 (6%)

Query: 159 KKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLA 218
           + +V  +TD+++ + +L+ +  WM+EFYAPWC  C+NL+PEW + A   ++    +V +A
Sbjct: 28  RSNVRVITDENW-RELLEGD--WMIEFYAPWCPACQNLQPEWESFAEWGEDL---EVNIA 81

Query: 219 AVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVS 263
            VD T    L+ R+ I   PTI   + GE    Y G RT+ D ++
Sbjct: 82  KVDVTEQPGLSGRFIITALPTIYHCKDGEFR-RYQGPRTKKDFIN 125



 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 34/97 (35%), Positives = 53/97 (54%), Gaps = 6/97 (6%)

Query: 30  LTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDV-VKVGAVDADKHHS 88
           +T  N+ RE+++ D  W++EFYAPWC  CQ L PEW+  A   +D+ V +  VD  +   
Sbjct: 34  ITDENW-RELLEGD--WMIEFYAPWCPACQNLQPEWESFAEWGEDLEVNIAKVDVTEQPG 90

Query: 89  LGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVD 125
           L G++ +   PT  I+         YQG RT +  ++
Sbjct: 91  LSGRFIITALPT--IYHCKDGEFRRYQGPRTKKDFIN 125


>gi|145580631 quiescin Q6 sulfhydryl oxidase 2 [Homo sapiens]
          Length = 698

 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 43/155 (27%), Positives = 72/155 (46%), Gaps = 10/155 (6%)

Query: 20  LYSSSDDVIELTPSNFNR-EVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKD---V 75
           LY + +D + +  S   R     S + WLV+FY+ WCGHC    P W+  A  ++D    
Sbjct: 55  LYRAGEDAVWVLDSGSVRGATANSSAAWLVQFYSSWCGHCIGYAPTWRALAGDVRDWASA 114

Query: 76  VKVGAVDA--DKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQ 133
           ++V A+D   +K+ ++   Y +  +PT + F   K   +++  G   +   D  L  +RQ
Sbjct: 115 IRVAALDCMEEKNQAVCHDYDIHFYPTFRYF---KAFTKEFTTGENFKG-PDRELRTVRQ 170

Query: 134 LVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDD 168
            + D L   + G       R D     DV+ L D+
Sbjct: 171 TMIDFLQNHTEGSRPPACPRLDPIQPSDVLSLLDN 205



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 32/108 (29%), Positives = 51/108 (47%), Gaps = 3/108 (2%)

Query: 139 LGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEP 198
           L   + G  +G   R   + +  V  L   S      +S   W+V+FY+ WCGHC    P
Sbjct: 40  LAAAAVGPGAGGAARLYRAGEDAVWVLDSGSVRGATANSSAAWLVQFYSSWCGHCIGYAP 99

Query: 199 EWAAAASEVKEQTKGKVKLAAVDA--TVNQVLASRYGIRGFPTIKIFQ 244
            W A A +V++     +++AA+D     NQ +   Y I  +PT + F+
Sbjct: 100 TWRALAGDVRDWASA-IRVAALDCMEEKNQAVCHDYDIHFYPTFRYFK 146


>gi|51873067 quiescin Q6 sulfhydryl oxidase 1 isoform b [Homo
           sapiens]
          Length = 604

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 36/95 (37%), Positives = 48/95 (50%), Gaps = 4/95 (4%)

Query: 153 RSDSSSKKDVIELTD-DSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQT 211
           RS   S  D + L   D+    VL S   W VEF+A WCGHC    P W A A +VK   
Sbjct: 32  RSALYSPSDPLTLLQADTVRGAVLGSRSAWAVEFFASWCGHCIAFAPTWKALAEDVK-AW 90

Query: 212 KGKVKLAAVDAT--VNQVLASRYGIRGFPTIKIFQ 244
           +  + LAA+D     N  +   + I GFPT++ F+
Sbjct: 91  RPALYLAALDCAEETNSAVCRDFNIPGFPTVRFFK 125



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 31/92 (33%), Positives = 47/92 (51%), Gaps = 5/92 (5%)

Query: 18  NGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAA---TALKD 74
           + LYS SD +  L        V+ S S W VEF+A WCGHC    P WK  A    A + 
Sbjct: 33  SALYSPSDPLTLLQADTVRGAVLGSRSAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRP 92

Query: 75  VVKVGAVDA--DKHHSLGGQYGVQGFPTIKIF 104
            + + A+D   + + ++   + + GFPT++ F
Sbjct: 93  ALYLAALDCAEETNSAVCRDFNIPGFPTVRFF 124


>gi|13325075 quiescin Q6 sulfhydryl oxidase 1 isoform a [Homo
           sapiens]
          Length = 747

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 36/95 (37%), Positives = 48/95 (50%), Gaps = 4/95 (4%)

Query: 153 RSDSSSKKDVIELTD-DSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQT 211
           RS   S  D + L   D+    VL S   W VEF+A WCGHC    P W A A +VK   
Sbjct: 32  RSALYSPSDPLTLLQADTVRGAVLGSRSAWAVEFFASWCGHCIAFAPTWKALAEDVK-AW 90

Query: 212 KGKVKLAAVDAT--VNQVLASRYGIRGFPTIKIFQ 244
           +  + LAA+D     N  +   + I GFPT++ F+
Sbjct: 91  RPALYLAALDCAEETNSAVCRDFNIPGFPTVRFFK 125



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 31/92 (33%), Positives = 47/92 (51%), Gaps = 5/92 (5%)

Query: 18  NGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAA---TALKD 74
           + LYS SD +  L        V+ S S W VEF+A WCGHC    P WK  A    A + 
Sbjct: 33  SALYSPSDPLTLLQADTVRGAVLGSRSAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRP 92

Query: 75  VVKVGAVDA--DKHHSLGGQYGVQGFPTIKIF 104
            + + A+D   + + ++   + + GFPT++ F
Sbjct: 93  ALYLAALDCAEETNSAVCRDFNIPGFPTVRFF 124


>gi|52487191 thioredoxin domain containing 4 (endoplasmic reticulum)
           [Homo sapiens]
          Length = 406

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 33/122 (27%), Positives = 64/122 (52%), Gaps = 8/122 (6%)

Query: 11  CTFFLAVNGLYSS-SDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAA 69
           C+  L V  +++  + ++  L   N + E++ +  + LV FYA WC   Q L P +++A+
Sbjct: 14  CSLLLLVTWVFTPVTTEITSLDTENID-EILNNADVALVNFYADWCRFSQMLHPIFEEAS 72

Query: 70  TALKDV------VKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAI 123
             +K+       V    VD D+H  +  +Y +  +PT+K+F +      +Y+G R+ +A+
Sbjct: 73  DVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKAL 132

Query: 124 VD 125
            D
Sbjct: 133 AD 134



 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 29/88 (32%), Positives = 51/88 (57%), Gaps = 3/88 (3%)

Query: 161 DVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQ--TKGKVKLA 218
           ++  L  ++ D+ +L++ DV +V FYA WC   + L P +  A+  +KE+   + +V  A
Sbjct: 30  EITSLDTENIDE-ILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFA 88

Query: 219 AVDATVNQVLASRYGIRGFPTIKIFQKG 246
            VD   +  +A RY I  +PT+K+F+ G
Sbjct: 89  RVDCDQHSDIAQRYRISKYPTLKLFRNG 116


>gi|21361403 thioredoxin 2 precursor [Homo sapiens]
          Length = 166

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 23/68 (33%), Positives = 35/68 (51%)

Query: 34  NFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQY 93
           +F   V+ S++  +V+F+A WCG C+ L P  +K        V +  VD D H  L  +Y
Sbjct: 69  DFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEY 128

Query: 94  GVQGFPTI 101
            V   PT+
Sbjct: 129 EVSAVPTV 136



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 26/78 (33%), Positives = 40/78 (51%), Gaps = 4/78 (5%)

Query: 170 FDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLA 229
           F   V++SE   +V+F+A WCG CK L P       ++  +  GKV +A VD   +  LA
Sbjct: 70  FQDRVVNSETPVVVDFHAQWCGPCKILGPR----LEKMVAKQHGKVVMAKVDIDDHTDLA 125

Query: 230 SRYGIRGFPTIKIFQKGE 247
             Y +   PT+   + G+
Sbjct: 126 IEYEVSAVPTVLAMKNGD 143


>gi|40254947 thioredoxin-related transmembrane protein 4 [Homo
           sapiens]
          Length = 349

 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 32/115 (27%), Positives = 53/115 (46%), Gaps = 6/115 (5%)

Query: 30  LTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDV-VKVGAVDADKHHS 88
           +T SN+    +  +  W+++FYAPWC  CQ+   EW+  A   + + + VG VD  +   
Sbjct: 42  MTASNWT---LVMEGEWMLKFYAPWCPSCQQTDSEWEAFAKNGEILQISVGKVDVIQEPG 98

Query: 89  LGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRS 143
           L G++ V   P    F +       Y+G    E + +  L    Q V+   G +S
Sbjct: 99  LSGRFFVTTLPA--FFHAKDGIFRRYRGPGIFEDLQNYILEKKWQSVEPLTGWKS 151



 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 18/40 (45%), Positives = 25/40 (62%), Gaps = 2/40 (5%)

Query: 178 EDVWMVEFYAPWCGHCKNLEPEWAAAA--SEVKEQTKGKV 215
           E  WM++FYAPWC  C+  + EW A A   E+ + + GKV
Sbjct: 52  EGEWMLKFYAPWCPSCQQTDSEWEAFAKNGEILQISVGKV 91


>gi|237648961 thioredoxin domain containing 16 isoform 2 [Homo
           sapiens]
          Length = 820

 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 27/100 (27%), Positives = 50/100 (50%), Gaps = 4/100 (4%)

Query: 163 IELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDA 222
           +ELT+++F+  V+ S+ +  V FYA W          +   A  VK +    + L  ++ 
Sbjct: 389 VELTEETFNATVMASDSI--VLFYAGWQAVSMAFLQSYIDVA--VKLKGTSTMLLTRINC 444

Query: 223 TVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIV 262
                + ++  +  FP IK+++KGE+PV Y G     D++
Sbjct: 445 ADWSDVCTKQNVTEFPIIKMYKKGENPVSYAGMLGTEDLL 484



 Score = 33.1 bits (74), Expect = 0.51
 Identities = 26/91 (28%), Positives = 39/91 (42%), Gaps = 5/91 (5%)

Query: 28  IELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALK--DVVKVGAVDADK 85
           +ELT   FN  V+ SDS  +V FYA W          +   A  LK    + +  ++   
Sbjct: 389 VELTEETFNATVMASDS--IVLFYAGWQAVSMAFLQSYIDVAVKLKGTSTMLLTRINCAD 446

Query: 86  HHSLGGQYGVQGFPTIKIFGSNKNRPEDYQG 116
              +  +  V  FP IK++   +N P  Y G
Sbjct: 447 WSDVCTKQNVTEFPIIKMYKKGEN-PVSYAG 476


>gi|237648959 thioredoxin domain containing 16 isoform 1 [Homo
           sapiens]
          Length = 825

 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 27/100 (27%), Positives = 50/100 (50%), Gaps = 4/100 (4%)

Query: 163 IELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDA 222
           +ELT+++F+  V+ S+ +  V FYA W          +   A  VK +    + L  ++ 
Sbjct: 394 VELTEETFNATVMASDSI--VLFYAGWQAVSMAFLQSYIDVA--VKLKGTSTMLLTRINC 449

Query: 223 TVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIV 262
                + ++  +  FP IK+++KGE+PV Y G     D++
Sbjct: 450 ADWSDVCTKQNVTEFPIIKMYKKGENPVSYAGMLGTEDLL 489



 Score = 33.1 bits (74), Expect = 0.51
 Identities = 26/91 (28%), Positives = 39/91 (42%), Gaps = 5/91 (5%)

Query: 28  IELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALK--DVVKVGAVDADK 85
           +ELT   FN  V+ SDS  +V FYA W          +   A  LK    + +  ++   
Sbjct: 394 VELTEETFNATVMASDS--IVLFYAGWQAVSMAFLQSYIDVAVKLKGTSTMLLTRINCAD 451

Query: 86  HHSLGGQYGVQGFPTIKIFGSNKNRPEDYQG 116
              +  +  V  FP IK++   +N P  Y G
Sbjct: 452 WSDVCTKQNVTEFPIIKMYKKGEN-PVSYAG 481


>gi|54633317 thioredoxin domain containing 11 [Homo sapiens]
          Length = 958

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 27/92 (29%), Positives = 46/92 (50%), Gaps = 5/92 (5%)

Query: 152 GRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQT 211
           G +   S+  + E+T D+F + VL  +DV ++ +YAPWCG C +L   +   A  +   T
Sbjct: 655 GSAQFPSQHLITEVTTDTFWEVVLQKQDVLLL-YYAPWCGFCPSLNHIFIQLARNLPMDT 713

Query: 212 KGKVKLAAVDATVNQVLASRYGIRGFPTIKIF 243
                +A +D + N  L   + +   PT+  F
Sbjct: 714 ---FTVARIDVSQND-LPWEFMVDRLPTVLFF 741



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 26/89 (29%), Positives = 42/89 (47%), Gaps = 3/89 (3%)

Query: 21  YSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATAL-KDVVKVG 79
           + S   + E+T   F   V+Q   + L+ +YAPWCG C  L   + + A  L  D   V 
Sbjct: 659 FPSQHLITEVTTDTFWEVVLQKQDVLLL-YYAPWCGFCPSLNHIFIQLARNLPMDTFTVA 717

Query: 80  AVDADKHHSLGGQYGVQGFPTIKIFGSNK 108
            +D  + + L  ++ V   PT+  F  N+
Sbjct: 718 RIDVSQ-NDLPWEFMVDRLPTVLFFPCNR 745



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 28/101 (27%), Positives = 45/101 (44%), Gaps = 7/101 (6%)

Query: 157 SSKKDVIELTDDSFD--KNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGK 214
           S +  V++L     D  + V    +V ++ FYAPWCG       E   AAS + +Q    
Sbjct: 102 SLRSPVLDLFQGQLDYAEYVRRDSEVVLLFFYAPWCGQSIAARAEIEQAASRLSDQ---- 157

Query: 215 VKLAAVDATVNQ-VLASRYGIRGFPTIKIFQKGESPVDYDG 254
           V   A++   NQ     +     FP I ++ +   P++Y G
Sbjct: 158 VLFVAINCWWNQGKCRKQKHFFYFPVIYLYHRSFGPIEYKG 198



 Score = 32.7 bits (73), Expect = 0.67
 Identities = 18/46 (39%), Positives = 27/46 (58%), Gaps = 1/46 (2%)

Query: 38  EVIQSDS-LWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVD 82
           E ++ DS + L+ FYAPWCG       E ++AA+ L D V   A++
Sbjct: 119 EYVRRDSEVVLLFFYAPWCGQSIAARAEIEQAASRLSDQVLFVAIN 164


>gi|50592994 thioredoxin [Homo sapiens]
          Length = 105

 Score = 40.0 bits (92), Expect = 0.004
 Identities = 28/97 (28%), Positives = 45/97 (46%), Gaps = 12/97 (12%)

Query: 158 SKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKL 217
           SK    E  D + DK V+       V+F A WCG CK ++P + + + +        V  
Sbjct: 7   SKTAFQEALDAAGDKLVV-------VDFSATWCGPCKMIKPFFHSLSEKY-----SNVIF 54

Query: 218 AAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDG 254
             VD    Q +AS   ++  PT + F+KG+   ++ G
Sbjct: 55  LEVDVDDCQDVASECEVKCMPTFQFFKKGQKVGEFSG 91



 Score = 36.2 bits (82), Expect = 0.061
 Identities = 22/80 (27%), Positives = 37/80 (46%), Gaps = 11/80 (13%)

Query: 43  DSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIK 102
           D L +V+F A WCG C+ + P +   +    +V+ +  VD D    +  +  V+  PT +
Sbjct: 20  DKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFL-EVDVDDCQDVASECEVKCMPTFQ 78

Query: 103 IF----------GSNKNRPE 112
            F          G+NK + E
Sbjct: 79  FFKKGQKVGEFSGANKEKLE 98


>gi|94421469 disulfide isomerase [Homo sapiens]
          Length = 360

 Score = 38.9 bits (89), Expect = 0.009
 Identities = 24/77 (31%), Positives = 32/77 (41%), Gaps = 1/77 (1%)

Query: 47  LVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGS 106
           LV FY PWC     L P +     A    +   A+DA +H SL  ++G    P I +F  
Sbjct: 212 LVLFYTPWCRFSASLAPHFNSLPRAFP-ALHFLALDASQHSSLSTRFGTVAVPNILLFQG 270

Query: 107 NKNRPEDYQGGRTGEAI 123
            K         RT E +
Sbjct: 271 AKPMARFNHTDRTLETL 287



 Score = 37.7 bits (86), Expect = 0.021
 Identities = 23/89 (25%), Positives = 42/89 (47%), Gaps = 6/89 (6%)

Query: 162 VIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVD 221
           ++ ++ D  D    +  D  +V FY PWC    +L P + +       +    +   A+D
Sbjct: 192 ILNMSQDLMDFLNPNGSDCTLVLFYTPWCRFSASLAPHFNSL-----PRAFPALHFLALD 246

Query: 222 ATVNQVLASRYGIRGFPTIKIFQKGESPV 250
           A+ +  L++R+G    P I +FQ G  P+
Sbjct: 247 ASQHSSLSTRFGTVAVPNILLFQ-GAKPM 274


>gi|28372543 protein disulfide isomerase-like, testis expressed
           [Homo sapiens]
          Length = 584

 Score = 38.1 bits (87), Expect = 0.016
 Identities = 29/97 (29%), Positives = 41/97 (42%), Gaps = 5/97 (5%)

Query: 162 VIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVD 221
           V +L   +F+  V D E    V FYAPW   CK L P         K Q    + +A +D
Sbjct: 389 VKQLVGKNFNVVVFDKEKDVFVMFYAPWSKKCKMLFPLLEELGR--KYQNHSTIIIAKID 446

Query: 222 ATVNQVLASRYGIRGFPTIKIFQKG-ESPVDYDGGRT 257
            T N +      +  +P  ++F  G +  V Y G  T
Sbjct: 447 VTANDI--QLMYLDRYPFFRLFPSGSQQAVLYKGEHT 481



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 28/118 (23%), Positives = 49/118 (41%), Gaps = 14/118 (11%)

Query: 27  VIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTP-------EWKKAATALKDVVKVG 79
           V +L   NFN  V   +    V FYAPW   C+ L P       +++  +T +   + V 
Sbjct: 389 VKQLVGKNFNVVVFDKEKDVFVMFYAPWSKKCKMLFPLLEELGRKYQNHSTIIIAKIDVT 448

Query: 80  AVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKD 137
           A D    +       +  +P  ++F S   +   Y+G  T +   D   S ++  ++D
Sbjct: 449 ANDIQLMY-------LDRYPFFRLFPSGSQQAVLYKGEHTLKGFSDFLESHIKTKIED 499



 Score = 33.5 bits (75), Expect = 0.39
 Identities = 20/65 (30%), Positives = 31/65 (47%), Gaps = 1/65 (1%)

Query: 182 MVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIK 241
           MV F+ P     +NL  E   A  E+  + K  +    VD T+ + L   +GI   P +K
Sbjct: 64  MVLFHNPSSKQSRNLAEELGKAV-EIMGKGKNGIGFGKVDITIEKELQQEFGITKAPELK 122

Query: 242 IFQKG 246
           +F +G
Sbjct: 123 LFFEG 127



 Score = 30.0 bits (66), Expect = 4.4
 Identities = 26/102 (25%), Positives = 47/102 (46%), Gaps = 5/102 (4%)

Query: 27  VIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATAL---KDVVKVGAVDA 83
           ++ LTP+   + + Q+  L +V F+ P     + L  E  KA   +   K+ +  G VD 
Sbjct: 45  LLVLTPAGLTQMLNQTRFL-MVLFHNPSSKQSRNLAEELGKAVEIMGKGKNGIGFGKVDI 103

Query: 84  DKHHSLGGQYGVQGFPTIKI-FGSNKNRPEDYQGGRTGEAIV 124
                L  ++G+   P +K+ F  N++ P   +G     A+V
Sbjct: 104 TIEKELQQEFGITKAPELKLFFEGNRSEPISCKGVVESAALV 145


>gi|56687498 DnaJ (Hsp40) homolog, subfamily C, member 16 [Homo
           sapiens]
          Length = 782

 Score = 35.8 bits (81), Expect = 0.079
 Identities = 20/76 (26%), Positives = 34/76 (44%), Gaps = 8/76 (10%)

Query: 27  VIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDV-VKVGAVDADK 85
           V E+ P +F +        +L++  + WC  C  + P WK+    L+++ V +G V A  
Sbjct: 150 VNEVVPDSFKKP-------YLIKITSDWCFSCIHIEPVWKEVIQELEELGVGIGVVHAGY 202

Query: 86  HHSLGGQYGVQGFPTI 101
              L    G    P+I
Sbjct: 203 ERRLAHHLGAHSTPSI 218



 Score = 34.7 bits (78), Expect = 0.18
 Identities = 22/79 (27%), Positives = 35/79 (44%), Gaps = 10/79 (12%)

Query: 162 VIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVD 221
           V E+  DSF K        ++++  + WC  C ++EP W     E++E   G   +  V 
Sbjct: 150 VNEVVPDSFKKP-------YLIKITSDWCFSCIHIEPVWKEVIQELEELGVG---IGVVH 199

Query: 222 ATVNQVLASRYGIRGFPTI 240
           A   + LA   G    P+I
Sbjct: 200 AGYERRLAHHLGAHSTPSI 218


>gi|95113651 glutaredoxin 3 [Homo sapiens]
          Length = 335

 Score = 35.0 bits (79), Expect = 0.14
 Identities = 26/115 (22%), Positives = 47/115 (40%), Gaps = 6/115 (5%)

Query: 175 LDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGI 234
           L ++ + +V F+APW   C  +    A  A E+ +     V    ++A     ++ +Y I
Sbjct: 28  LKAKSLLVVHFWAPWAPQCAQMNEVMAELAKELPQ-----VSFVKLEAEGVPEVSEKYEI 82

Query: 235 RGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKR 289
              PT  +F K    +D   G    ++  +     S  +  P   E + ED+  R
Sbjct: 83  SSVPTF-LFFKNSQKIDRLDGAHAPELTKKVQRHASSGSFLPSANEHLKEDLNLR 136



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 20/82 (24%), Positives = 37/82 (45%), Gaps = 2/82 (2%)

Query: 40  IQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFP 99
           +++ SL +V F+APW   C ++     + A  L  V  V  ++A+    +  +Y +   P
Sbjct: 28  LKAKSLLVVHFWAPWAPQCAQMNEVMAELAKELPQVSFV-KLEAEGVPEVSEKYEISSVP 86

Query: 100 TIKIFGSNKNRPEDYQGGRTGE 121
           T  +F  N  + +   G    E
Sbjct: 87  TF-LFFKNSQKIDRLDGAHAPE 107


>gi|221136993 thioredoxin domain containing 14 isoform 2 [Homo
           sapiens]
          Length = 258

 Score = 33.9 bits (76), Expect = 0.30
 Identities = 24/87 (27%), Positives = 38/87 (43%), Gaps = 11/87 (12%)

Query: 46  WLVEFYAPWCGHCQRLTPEWKKAATALK---DVVKVGAVDADKHHSLGGQYGV------Q 96
           W+VEF+A W   CQ   P +  A  +LK     +  G VD  ++  +  +Y V      +
Sbjct: 120 WIVEFFANWSNDCQSFAPIY--ADLSLKYNCTGLNFGKVDVGRYTDVSTRYKVSTSPLTK 177

Query: 97  GFPTIKIFGSNKNRPEDYQGGRTGEAI 123
             PT+ +F   K      Q  + G A+
Sbjct: 178 QLPTLILFQGGKEAMRRPQIDKKGRAV 204



 Score = 32.3 bits (72), Expect = 0.88
 Identities = 21/78 (26%), Positives = 37/78 (47%), Gaps = 9/78 (11%)

Query: 176 DSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGI- 234
           D    W+VEF+A W   C++  P +A  +  +K    G +    VD      +++RY + 
Sbjct: 115 DKRVTWIVEFFANWSNDCQSFAPIYADLS--LKYNCTG-LNFGKVDVGRYTDVSTRYKVS 171

Query: 235 -----RGFPTIKIFQKGE 247
                +  PT+ +FQ G+
Sbjct: 172 TSPLTKQLPTLILFQGGK 189


>gi|7705726 thioredoxin domain containing 14 isoform 1 [Homo
           sapiens]
          Length = 296

 Score = 33.9 bits (76), Expect = 0.30
 Identities = 24/87 (27%), Positives = 38/87 (43%), Gaps = 11/87 (12%)

Query: 46  WLVEFYAPWCGHCQRLTPEWKKAATALK---DVVKVGAVDADKHHSLGGQYGV------Q 96
           W+VEF+A W   CQ   P +  A  +LK     +  G VD  ++  +  +Y V      +
Sbjct: 158 WIVEFFANWSNDCQSFAPIY--ADLSLKYNCTGLNFGKVDVGRYTDVSTRYKVSTSPLTK 215

Query: 97  GFPTIKIFGSNKNRPEDYQGGRTGEAI 123
             PT+ +F   K      Q  + G A+
Sbjct: 216 QLPTLILFQGGKEAMRRPQIDKKGRAV 242



 Score = 32.3 bits (72), Expect = 0.88
 Identities = 21/78 (26%), Positives = 37/78 (47%), Gaps = 9/78 (11%)

Query: 176 DSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGI- 234
           D    W+VEF+A W   C++  P +A  +  +K    G +    VD      +++RY + 
Sbjct: 153 DKRVTWIVEFFANWSNDCQSFAPIYADLS--LKYNCTG-LNFGKVDVGRYTDVSTRYKVS 209

Query: 235 -----RGFPTIKIFQKGE 247
                +  PT+ +FQ G+
Sbjct: 210 TSPLTKQLPTLILFQGGK 227


>gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo
           sapiens]
          Length = 486

 Score = 33.5 bits (75), Expect = 0.39
 Identities = 18/62 (29%), Positives = 31/62 (50%), Gaps = 1/62 (1%)

Query: 43  DSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIK 102
           + L  V+F A WCG C+ + P +   +   +DVV +  VDAD    +  +  +   PT +
Sbjct: 401 ERLVAVDFSATWCGPCRTIRPFFHALSVKHEDVVFL-EVDADNCEEVVRECAIMCVPTFQ 459

Query: 103 IF 104
            +
Sbjct: 460 FY 461



 Score = 32.7 bits (73), Expect = 0.67
 Identities = 23/84 (27%), Positives = 42/84 (50%), Gaps = 6/84 (7%)

Query: 165 LTDDSFDKNVLDS-EDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDAT 223
           L+ + F+ ++ ++ E +  V+F A WCG C+ + P + A +  VK +    V    VDA 
Sbjct: 387 LSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFHALS--VKHE---DVVFLEVDAD 441

Query: 224 VNQVLASRYGIRGFPTIKIFQKGE 247
             + +     I   PT + ++K E
Sbjct: 442 NCEEVVRECAIMCVPTFQFYKKEE 465


>gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo
           sapiens]
          Length = 553

 Score = 33.5 bits (75), Expect = 0.39
 Identities = 18/62 (29%), Positives = 31/62 (50%), Gaps = 1/62 (1%)

Query: 43  DSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIK 102
           + L  V+F A WCG C+ + P +   +   +DVV +  VDAD    +  +  +   PT +
Sbjct: 468 ERLVAVDFSATWCGPCRTIRPFFHALSVKHEDVVFL-EVDADNCEEVVRECAIMCVPTFQ 526

Query: 103 IF 104
            +
Sbjct: 527 FY 528



 Score = 32.7 bits (73), Expect = 0.67
 Identities = 23/84 (27%), Positives = 42/84 (50%), Gaps = 6/84 (7%)

Query: 165 LTDDSFDKNVLDS-EDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDAT 223
           L+ + F+ ++ ++ E +  V+F A WCG C+ + P + A +  VK +    V    VDA 
Sbjct: 454 LSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFHALS--VKHE---DVVFLEVDAD 508

Query: 224 VNQVLASRYGIRGFPTIKIFQKGE 247
             + +     I   PT + ++K E
Sbjct: 509 NCEEVVRECAIMCVPTFQFYKKEE 532


>gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo
           sapiens]
          Length = 486

 Score = 33.5 bits (75), Expect = 0.39
 Identities = 18/62 (29%), Positives = 31/62 (50%), Gaps = 1/62 (1%)

Query: 43  DSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIK 102
           + L  V+F A WCG C+ + P +   +   +DVV +  VDAD    +  +  +   PT +
Sbjct: 401 ERLVAVDFSATWCGPCRTIRPFFHALSVKHEDVVFL-EVDADNCEEVVRECAIMCVPTFQ 459

Query: 103 IF 104
            +
Sbjct: 460 FY 461



 Score = 32.7 bits (73), Expect = 0.67
 Identities = 23/84 (27%), Positives = 42/84 (50%), Gaps = 6/84 (7%)

Query: 165 LTDDSFDKNVLDS-EDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDAT 223
           L+ + F+ ++ ++ E +  V+F A WCG C+ + P + A +  VK +    V    VDA 
Sbjct: 387 LSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFHALS--VKHE---DVVFLEVDAD 441

Query: 224 VNQVLASRYGIRGFPTIKIFQKGE 247
             + +     I   PT + ++K E
Sbjct: 442 NCEEVVRECAIMCVPTFQFYKKEE 465


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.136    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,879,603
Number of Sequences: 37866
Number of extensions: 752073
Number of successful extensions: 1912
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 1762
Number of HSP's gapped (non-prelim): 102
length of query: 440
length of database: 18,247,518
effective HSP length: 105
effective length of query: 335
effective length of database: 14,271,588
effective search space: 4780981980
effective search space used: 4780981980
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.