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Search of human proteins with 50086624
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50086624 integrator complex subunit 4 [Homo sapiens]
(963 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50086624 integrator complex subunit 4 [Homo sapiens] 1898 0.0
gi|171184451 centrosome-associated protein 350 [Homo sapiens] 37 0.068
gi|187171277 DNA-directed DNA polymerase gamma [Homo sapiens] 35 0.26
gi|4505937 DNA-directed DNA polymerase gamma [Homo sapiens] 35 0.26
gi|153791502 transmembrane and coiled-coil domains 7 [Homo sapiens] 35 0.26
gi|57863310 stromal antigen 3 [Homo sapiens] 35 0.44
gi|55749708 outer dense fiber of sperm tails 2-like isoform b [H... 34 0.58
gi|55749696 outer dense fiber of sperm tails 2-like isoform a [H... 34 0.58
gi|23943912 phosphoinositide-3-kinase, regulatory subunit 4 [Hom... 34 0.75
gi|21361399 alpha isoform of regulatory subunit A, protein phosp... 34 0.75
gi|54633317 thioredoxin domain containing 11 [Homo sapiens] 33 1.3
gi|76159293 thioesterase superfamily member 4 [Homo sapiens] 32 2.2
gi|194097475 izumo sperm-egg fusion 1 [Homo sapiens] 32 2.2
gi|150456463 gasdermin 1 [Homo sapiens] 32 3.7
gi|56549696 E1A binding protein p400 [Homo sapiens] 32 3.7
gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5 [... 31 4.9
gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4 [... 31 4.9
gi|157694494 MYB binding protein 1a isoform 1 [Homo sapiens] 31 6.4
gi|157694492 MYB binding protein 1a isoform 2 [Homo sapiens] 31 6.4
gi|8393009 chromosome 11 open reading frame2 [Homo sapiens] 31 6.4
gi|90991702 leucine-rich repeat kinase 1 [Homo sapiens] 30 8.3
gi|54607053 GCN1 general control of amino-acid synthesis 1-like ... 30 8.3
gi|109134349 coatomer protein complex, subunit gamma 2 [Homo sap... 30 8.3
gi|22027651 adaptor-related protein complex 1 beta 1 subunit iso... 30 8.3
gi|22027653 adaptor-related protein complex 1 beta 1 subunit iso... 30 8.3
>gi|50086624 integrator complex subunit 4 [Homo sapiens]
Length = 963
Score = 1898 bits (4917), Expect = 0.0
Identities = 963/963 (100%), Positives = 963/963 (100%)
Query: 1 MAAHLKKRVYEEFTKVVQPQEEIATKKLRLTKPSKSAALHIDLCKATSPADALQYLLQFA 60
MAAHLKKRVYEEFTKVVQPQEEIATKKLRLTKPSKSAALHIDLCKATSPADALQYLLQFA
Sbjct: 1 MAAHLKKRVYEEFTKVVQPQEEIATKKLRLTKPSKSAALHIDLCKATSPADALQYLLQFA 60
Query: 61 RKPVEAESVEGVVRILLEHYYKENDPSVRLKIASLLGLLSKTAGFSPDCIMDDAINILQN 120
RKPVEAESVEGVVRILLEHYYKENDPSVRLKIASLLGLLSKTAGFSPDCIMDDAINILQN
Sbjct: 61 RKPVEAESVEGVVRILLEHYYKENDPSVRLKIASLLGLLSKTAGFSPDCIMDDAINILQN 120
Query: 121 EKSHQVLAQLLDTLLAIGTKLPENQAIQMRLVDVACKHLTDTSHGVRNKCLQLLGNLGSL 180
EKSHQVLAQLLDTLLAIGTKLPENQAIQMRLVDVACKHLTDTSHGVRNKCLQLLGNLGSL
Sbjct: 121 EKSHQVLAQLLDTLLAIGTKLPENQAIQMRLVDVACKHLTDTSHGVRNKCLQLLGNLGSL 180
Query: 181 EKSVTKDAEGLAARDVQKIIGDYFSDQDPRVRTAAIKAMLQLHERGLKLHQTIYNQACKL 240
EKSVTKDAEGLAARDVQKIIGDYFSDQDPRVRTAAIKAMLQLHERGLKLHQTIYNQACKL
Sbjct: 181 EKSVTKDAEGLAARDVQKIIGDYFSDQDPRVRTAAIKAMLQLHERGLKLHQTIYNQACKL 240
Query: 241 LSDDYEQVRSAAVQLIWVVSQLYPESIVPIPSSNEEIRLVDDAFGKICHMVSDGSWVVRV 300
LSDDYEQVRSAAVQLIWVVSQLYPESIVPIPSSNEEIRLVDDAFGKICHMVSDGSWVVRV
Sbjct: 241 LSDDYEQVRSAAVQLIWVVSQLYPESIVPIPSSNEEIRLVDDAFGKICHMVSDGSWVVRV 300
Query: 301 QAAKLLGSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPK 360
QAAKLLGSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPK
Sbjct: 301 QAAKLLGSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPK 360
Query: 361 EEVDTGAVNLIESGACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFLVDMF 420
EEVDTGAVNLIESGACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFLVDMF
Sbjct: 361 EEVDTGAVNLIESGACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFLVDMF 420
Query: 421 NDEIEEVRLQSIHTMRKISNNITLREDQLDTVLAVLEDSSRDIREALHELLCCTNVSTKE 480
NDEIEEVRLQSIHTMRKISNNITLREDQLDTVLAVLEDSSRDIREALHELLCCTNVSTKE
Sbjct: 421 NDEIEEVRLQSIHTMRKISNNITLREDQLDTVLAVLEDSSRDIREALHELLCCTNVSTKE 480
Query: 481 GIHLALVELLKNLTKYPTDRDSIWKCLKFLGSRHPTLVLPLVPELLSTHPFFDTAEPDMD 540
GIHLALVELLKNLTKYPTDRDSIWKCLKFLGSRHPTLVLPLVPELLSTHPFFDTAEPDMD
Sbjct: 481 GIHLALVELLKNLTKYPTDRDSIWKCLKFLGSRHPTLVLPLVPELLSTHPFFDTAEPDMD 540
Query: 541 DPAYIAVLVLIFNAAKTCPTMPALFSDHTFRHYAYLRDSLSHLVPALRLPGRKLVSSAVS 600
DPAYIAVLVLIFNAAKTCPTMPALFSDHTFRHYAYLRDSLSHLVPALRLPGRKLVSSAVS
Sbjct: 541 DPAYIAVLVLIFNAAKTCPTMPALFSDHTFRHYAYLRDSLSHLVPALRLPGRKLVSSAVS 600
Query: 601 PSIIPQEDPSQQFLQQSLERVYSLQHLDPQGAQELLEFTIRDLQRLGELQSELAGVADFS 660
PSIIPQEDPSQQFLQQSLERVYSLQHLDPQGAQELLEFTIRDLQRLGELQSELAGVADFS
Sbjct: 601 PSIIPQEDPSQQFLQQSLERVYSLQHLDPQGAQELLEFTIRDLQRLGELQSELAGVADFS 660
Query: 661 ATYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVV 720
ATYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVV
Sbjct: 661 ATYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVV 720
Query: 721 IIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFVDKL 780
IIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFVDKL
Sbjct: 721 IIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFVDKL 780
Query: 781 LDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSG 840
LDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSG
Sbjct: 781 LDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSG 840
Query: 841 LVVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQVYLSH 900
LVVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQVYLSH
Sbjct: 841 LVVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQVYLSH 900
Query: 901 TAWTEACQVEVRLLLAYNSSARIPKCPWMEGGEMSPQVETSIEGTIPFSKPVKVYIMPKP 960
TAWTEACQVEVRLLLAYNSSARIPKCPWMEGGEMSPQVETSIEGTIPFSKPVKVYIMPKP
Sbjct: 901 TAWTEACQVEVRLLLAYNSSARIPKCPWMEGGEMSPQVETSIEGTIPFSKPVKVYIMPKP 960
Query: 961 ARR 963
ARR
Sbjct: 961 ARR 963
>gi|171184451 centrosome-associated protein 350 [Homo sapiens]
Length = 3117
Score = 37.4 bits (85), Expect = 0.068
Identities = 74/310 (23%), Positives = 116/310 (37%), Gaps = 48/310 (15%)
Query: 165 GVRNKCLQLLGNLGSLEKSVTKDAEGLAARDVQKIIGDYFSDQDPRVRTAAIKAMLQLHE 224
G+ ++ L L ++E+SV + DV+++ G + Q+ IKA Q HE
Sbjct: 1324 GLHHRMAAELSYLNAIEESVRQ------LSDVERVRGISLAQQESVSLAQIIKAQQQRHE 1377
Query: 225 RGLKLHQTIYNQACKLLSDDYEQVRSAA-----------VQLIWVVSQLYPESIVPIPS- 272
R L L + Q E+ R+ A VQ V+++ E+ I +
Sbjct: 1378 RDLALLKLKAEQEALESQRQLEETRNKAAQVHAESLQQVVQSQREVTEVLQEATCKIAAQ 1437
Query: 273 SNEEIRLVDDAFGKICHM-------VSDGSWVVRVQAAKLLGSMEQVSSHFLEQ-----T 320
+E RL DA +IC M +SD A L Q F++Q
Sbjct: 1438 QSETARLTTDAARQICEMAELTRTHISDAVVASGAPLAILYDHQRQHLPDFVKQLRTRTE 1497
Query: 321 LDKKLMS-DLRRKR-----TAHERAKELYSSGEFSSGRKWGD------DAPKEEVDTGAV 368
D+K S L + + + H++ Y S SSG K D + +E +
Sbjct: 1498 TDRKSPSVSLSQSKEGTLDSKHQKYSASYDSYSESSGYKNHDRRSSSGSSRQESPSVPSC 1557
Query: 369 NLIESGACGAFVHGLEDEMYE------VRIAAVEALCMLAQSSPSFAEKCLDFLVDMFND 422
E G + DE + +R +V +L S+ E L F M D
Sbjct: 1558 KENEKKLNGEKIESSIDEQVQTAADDSLRSDSVPSLPDEKDSTSIATEYSLKFDESMTED 1617
Query: 423 EIEEVRLQSI 432
EIEE +S+
Sbjct: 1618 EIEEQSFRSL 1627
>gi|187171277 DNA-directed DNA polymerase gamma [Homo sapiens]
Length = 1239
Score = 35.4 bits (80), Expect = 0.26
Identities = 46/155 (29%), Positives = 67/155 (43%), Gaps = 15/155 (9%)
Query: 506 CLKFLGSRHPTLVLPLVPELLSTHP-FFDTAEPDMDDPAYIAVLVLIFNAAKTCPTMPAL 564
CL+ L + T +LP P+ L HP ++ P +DDPA+ L+ + P + AL
Sbjct: 548 CLQKL--KGTTELLPKRPQHLPGHPGWYRKLCPRLDDPAWTPGPSLLSLQMRVTPKLMAL 605
Query: 565 FSDHTFRHYAYLRDSLSHLVPALR-----LP-GRKLVSSAVSPSIIPQEDPSQQFLQQSL 618
D HY+ R +LVP R LP G L S+ V + P + + L
Sbjct: 606 TWDGFPLHYSE-RHGWGYLVPGRRDNLAKLPTGTTLESAGV---VCPYRAIESLYRKHCL 661
Query: 619 ERVYSLQHLDPQGAQELLEFTIRDLQRLGELQSEL 653
E+ Q L PQ A EF + D + + EL
Sbjct: 662 EQ--GKQQLMPQEAGLAEEFLLTDNSAIWQTVEEL 694
>gi|4505937 DNA-directed DNA polymerase gamma [Homo sapiens]
Length = 1239
Score = 35.4 bits (80), Expect = 0.26
Identities = 46/155 (29%), Positives = 67/155 (43%), Gaps = 15/155 (9%)
Query: 506 CLKFLGSRHPTLVLPLVPELLSTHP-FFDTAEPDMDDPAYIAVLVLIFNAAKTCPTMPAL 564
CL+ L + T +LP P+ L HP ++ P +DDPA+ L+ + P + AL
Sbjct: 548 CLQKL--KGTTELLPKRPQHLPGHPGWYRKLCPRLDDPAWTPGPSLLSLQMRVTPKLMAL 605
Query: 565 FSDHTFRHYAYLRDSLSHLVPALR-----LP-GRKLVSSAVSPSIIPQEDPSQQFLQQSL 618
D HY+ R +LVP R LP G L S+ V + P + + L
Sbjct: 606 TWDGFPLHYSE-RHGWGYLVPGRRDNLAKLPTGTTLESAGV---VCPYRAIESLYRKHCL 661
Query: 619 ERVYSLQHLDPQGAQELLEFTIRDLQRLGELQSEL 653
E+ Q L PQ A EF + D + + EL
Sbjct: 662 EQ--GKQQLMPQEAGLAEEFLLTDNSAIWQTVEEL 694
>gi|153791502 transmembrane and coiled-coil domains 7 [Homo sapiens]
Length = 1094
Score = 35.4 bits (80), Expect = 0.26
Identities = 50/236 (21%), Positives = 103/236 (43%), Gaps = 30/236 (12%)
Query: 60 ARKPVEAESVE---GVVRILLEH--YYKENDPSVRLKIASLLGLLSKTAGFSPDCIMDD- 113
A VE++++ G+V ++L K +D +V + LL LL K + PD ++ +
Sbjct: 684 AESTVESQTLSMSMGLVAVMLGGAVQLKSSDFAV---LKQLLPLLEKVSNTYPDPVIQEL 740
Query: 114 AINILQNEKSHQVLAQLLDTLLAIGT--------KLPENQAIQM-RLVDVACKHL----- 159
A+++ +H A ++ A T K+ E Q R DVA HL
Sbjct: 741 AVDLRITISTHGAFATEAVSMAAQSTLNRKDLEGKIEEQQQTSHERPTDVAHSHLEQQQS 800
Query: 160 --TDTSHGVRNKCLQLLGNLGSLEKSVTKDAEGLAARDVQKIIGDYFSDQDPRVRTAAIK 217
T G+++ + + + ++ + + +Q+++ + Q P R AA++
Sbjct: 801 HETAPQTGLQSNAPIIPQGVNEPSTTTSQKSGSVTTEQLQEVLLSAYDPQIP-TRAAALR 859
Query: 218 AML----QLHERGLKLHQTIYNQACKLLSDDYEQVRSAAVQLIWVVSQLYPESIVP 269
+ Q + L++ + + + L + V +A+Q + ++S +YPE I+P
Sbjct: 860 TLSHWIEQREAKALEMQEKLLKIFLENLEHEDTFVYLSAIQGVALLSDVYPEKILP 915
>gi|57863310 stromal antigen 3 [Homo sapiens]
Length = 1225
Score = 34.7 bits (78), Expect = 0.44
Identities = 49/209 (23%), Positives = 91/209 (43%), Gaps = 31/209 (14%)
Query: 302 AAKLLGSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPKE 361
A KL+ S+ +V+ + + + R + +RA E S RK + +E
Sbjct: 239 AMKLMTSLVKVALQLSVHQDNNQRQYEAERNKGPGQRAPERLES--LLEKRKELQEH-QE 295
Query: 362 EVDTGAVNLIESGACGAFVHGLEDEMYEVRIAAVEAL-CMLAQSSPSF-AEKCLDFLVDM 419
E++ G +N + G FVH D + E+R +E + C + S SF + L ++
Sbjct: 296 EIE-GMMNALFRGV---FVHRYRDVLPEIRAICIEEIGCWMQSYSTSFLTDSYLKYIGWT 351
Query: 420 FNDEIEEVRLQSIHTMRKISNN--ITLREDQL-----DTVLAVLEDSSRDIREALHELLC 472
+D+ EVRL+ + ++ + N +T R + D +++++ D D+
Sbjct: 352 LHDKHREVRLKCVKALKGLYGNRDLTTRLELFTSRFKDRMVSMVMDREYDV--------- 402
Query: 473 CTNVSTKEGIHLALVELLKNLTKYPTDRD 501
E + L L+ +LKN+ TD D
Sbjct: 403 -----AVEAVRL-LILILKNMEGVLTDAD 425
>gi|55749708 outer dense fiber of sperm tails 2-like isoform b [Homo
sapiens]
Length = 513
Score = 34.3 bits (77), Expect = 0.58
Identities = 36/136 (26%), Positives = 61/136 (44%), Gaps = 9/136 (6%)
Query: 384 EDEMYEVRIAAVEALCMLAQSSPSFAEKCLDF--LVDMFNDEIEEVRLQSIHTMRKISNN 441
E++ E ++A E L S+ F EK ++ L +EE R + + K+S+
Sbjct: 383 ENKELEKKLANQEEC--LKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSS- 439
Query: 442 ITLREDQLDTVLAVLEDSSRDIREALHELLCCTNVSTKEGIHLALVELLKNLTKYPTDRD 501
RE L + LE R E ++L+C N S + + L E+ +L K +
Sbjct: 440 ---RESALQIKILDLETELRKKNEEQNQLVCKMN-SKAQHQEVCLKEVQNSLEKSENQNE 495
Query: 502 SIWKCLKFLGSRHPTL 517
SI L+FL + + T+
Sbjct: 496 SIKNYLQFLKTSYVTM 511
>gi|55749696 outer dense fiber of sperm tails 2-like isoform a [Homo
sapiens]
Length = 644
Score = 34.3 bits (77), Expect = 0.58
Identities = 36/136 (26%), Positives = 61/136 (44%), Gaps = 9/136 (6%)
Query: 384 EDEMYEVRIAAVEALCMLAQSSPSFAEKCLDF--LVDMFNDEIEEVRLQSIHTMRKISNN 441
E++ E ++A E L S+ F EK ++ L +EE R + + K+S+
Sbjct: 514 ENKELEKKLANQEEC--LKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSS- 570
Query: 442 ITLREDQLDTVLAVLEDSSRDIREALHELLCCTNVSTKEGIHLALVELLKNLTKYPTDRD 501
RE L + LE R E ++L+C N S + + L E+ +L K +
Sbjct: 571 ---RESALQIKILDLETELRKKNEEQNQLVCKMN-SKAQHQEVCLKEVQNSLEKSENQNE 626
Query: 502 SIWKCLKFLGSRHPTL 517
SI L+FL + + T+
Sbjct: 627 SIKNYLQFLKTSYVTM 642
>gi|23943912 phosphoinositide-3-kinase, regulatory subunit 4 [Homo
sapiens]
Length = 1358
Score = 33.9 bits (76), Expect = 0.75
Identities = 44/190 (23%), Positives = 79/190 (41%), Gaps = 36/190 (18%)
Query: 361 EEVDTGAVNLIESGACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAE----KCLDFL 416
+EV +N+ H +D+ VR+A E + +LA+++ F E K L+
Sbjct: 449 KEVPRNDINIYPEYILPGIAHLAQDDATIVRLAYAENIALLAETALRFLELVQLKNLNME 508
Query: 417 VDMFNDEIEEV---------RLQSIHTMRKISNNITLREDQLDTVLAVLEDSSRDIREAL 467
D N+EI+EV LQ++H M + V+ +L D +++ L
Sbjct: 509 NDPNNEEIDEVTHPNGNYDTELQALHEMVQ------------QKVVTLLSDPENIVKQTL 556
Query: 468 HELLCCTNVSTKEGIHLALVELLKNLTKYPTDR----------DSIWKCLKFLGSRHPTL 517
E T + G A LL ++ + D+ DSI ++G + ++
Sbjct: 557 ME-NGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGVAAYVGWQSSSI 615
Query: 518 VLPLVPELLS 527
+ PL+ + LS
Sbjct: 616 LKPLLQQGLS 625
>gi|21361399 alpha isoform of regulatory subunit A, protein
phosphatase 2 [Homo sapiens]
Length = 589
Score = 33.9 bits (76), Expect = 0.75
Identities = 60/275 (21%), Positives = 101/275 (36%), Gaps = 30/275 (10%)
Query: 205 SDQDPRVRTAAIKAMLQLHERGLKLHQT---IYNQACKLLSDDYEQVRSAAVQLIWVVSQ 261
SD P VR AA + + + L+L I L SD+ + VR AV+ ++Q
Sbjct: 175 SDDTPMVRRAAASKLGEF-AKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQ 233
Query: 262 LYPESIVPIPSSNEEIRLVDDAFGKICHMVSDGSWVVRVQAAKLLGSMEQVSSHFLEQTL 321
L P+ E++ + + D SW VR A +++ + +T
Sbjct: 234 LLPQ---------EDLEAL--VMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTD 282
Query: 322 DKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPKEEVDTGAVNLIESGACGAFVH 381
+L + A RA + EF A E N+I S
Sbjct: 283 LVPAFQNLMKDCEAEVRAAASHKVKEFCENLS----ADCRE------NVIMSQILPCIKE 332
Query: 382 GLEDEMYEVRIAAVEALCMLAQ--SSPSFAEKCLDFLVDMFNDEIEEVRLQSIHTMRKIS 439
+ D V+ A + L+ + E L + DE EVRL I + ++
Sbjct: 333 LVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVN 392
Query: 440 NNITLR---EDQLDTVLAVLEDSSRDIREALHELL 471
I +R + L ++ + ED+ +R A+ E +
Sbjct: 393 EVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYM 427
>gi|54633317 thioredoxin domain containing 11 [Homo sapiens]
Length = 958
Score = 33.1 bits (74), Expect = 1.3
Identities = 30/122 (24%), Positives = 51/122 (41%), Gaps = 2/122 (1%)
Query: 559 PTMPALFSDHTFR--HYAYLRDSLSHLVPALRLPGRKLVSSAVSPSIIPQEDPSQQFLQQ 616
PT L S+ + H ++L + L + R V S +++ + Q+
Sbjct: 784 PTKECLQSEAVLQRGHISHLEREIQKLRAEISSLQRAQVQVESQLSSARRDEHRLRQQQR 843
Query: 617 SLERVYSLQHLDPQGAQELLEFTIRDLQRLGELQSELAGVADFSATYLRCQLLLIKALQE 676
+LE +SL H + Q L E R+LQ L ELA ++ T +L+ ++
Sbjct: 844 ALEEQHSLLHAHSEQLQALYEQKTRELQELARKLQELADASENLLTENTWLKILVATMER 903
Query: 677 KL 678
KL
Sbjct: 904 KL 905
>gi|76159293 thioesterase superfamily member 4 [Homo sapiens]
Length = 240
Score = 32.3 bits (72), Expect = 2.2
Identities = 22/59 (37%), Positives = 34/59 (57%), Gaps = 6/59 (10%)
Query: 268 VPIPSSNEEIRLVDDAFGKICHMVSDGSWVVRVQAAKLLGS--MEQVSSHFLEQTLDKK 324
VP PS N+++RL+ D F K C DGSW R+ + K + ++ +HFL+ L K+
Sbjct: 48 VPNPSWNKDLRLLFDQFMKKC---EDGSW-KRLPSYKRTPTEWIQDFKTHFLDPKLMKE 102
>gi|194097475 izumo sperm-egg fusion 1 [Homo sapiens]
Length = 350
Score = 32.3 bits (72), Expect = 2.2
Identities = 28/94 (29%), Positives = 44/94 (46%), Gaps = 9/94 (9%)
Query: 590 PGRKLVSSAVSPSIIPQE-----DPSQQFLQQSLERVYSLQHLDP---QGAQELLEFTIR 641
P L+ +A++ ++P E DPS +SLE+ Y HLD + E +E ++
Sbjct: 3 PHFTLLCAALAGCLLPAEGCVICDPSVVLALKSLEKDYLPGHLDAKHHKAMMERVENAVK 62
Query: 642 DLQRLGELQSELAGVADFSATYLRCQLLLIKALQ 675
D Q L + GV D AT + L+K L+
Sbjct: 63 DFQELSLNEDAYMGVVD-EATLQKGSWSLLKDLK 95
>gi|150456463 gasdermin 1 [Homo sapiens]
Length = 445
Score = 31.6 bits (70), Expect = 3.7
Identities = 46/164 (28%), Positives = 72/164 (43%), Gaps = 32/164 (19%)
Query: 89 RLKIASLLGLLSKTAGFSPDCIMDDAINILQN--EKSHQVLAQLL--DTLL---AIG--- 138
R+ +SLL LSK G + + D L+ +K H+V + L D LL A+G
Sbjct: 276 RVGQSSLLSSLSKLLGKKKE--LQDLELALEGALDKGHEVTLEALPKDVLLSKEAVGAIL 333
Query: 139 ------TKLPENQ------AIQMRLVDVACKHLTDT--------SHGVRNKCLQLLGNLG 178
T+L E Q +++ +++ V K + T GV +LL +LG
Sbjct: 334 YFVGALTELSEAQQKLLVKSMEKKILPVQLKLVESTMEQNFLLDKEGVFPLQPELLSSLG 393
Query: 179 SLEKSVTKDAEGLAARDVQKIIGDYFSDQDPRVRTAAIKAMLQL 222
E ++T+ GL+ +VQ+ Y D D R A+ A L L
Sbjct: 394 DEELTLTEALVGLSGLEVQRSGPQYMWDPDTLPRLCALYAGLSL 437
>gi|56549696 E1A binding protein p400 [Homo sapiens]
Length = 3122
Score = 31.6 bits (70), Expect = 3.7
Identities = 33/123 (26%), Positives = 54/123 (43%), Gaps = 4/123 (3%)
Query: 588 RLPGRKLVSSAVSPSIIPQEDP--SQQFLQQSLERVYSLQHLDPQGAQELLEFTIRDLQR 645
R PG +V+SA + P ++ SQ Q +L +L++ Q EL + + +R
Sbjct: 704 RTPG--VVASAPTKPQSPAQNATSSQDSSQDTLTEQITLENQVHQRIAELRKAGLWSQRR 761
Query: 646 LGELQSELAGVADFSATYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETY 705
L +LQ + + Q + QE+ W VAA L ++ + KQ+ EE
Sbjct: 762 LPKLQEAPRPKSHWDYLLEEMQWMATDFAQERRWKVAAAKKLVRTVVRHHEEKQLREERG 821
Query: 706 KME 708
K E
Sbjct: 822 KKE 824
>gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5
[Homo sapiens]
Length = 558
Score = 31.2 bits (69), Expect = 4.9
Identities = 54/262 (20%), Positives = 105/262 (40%), Gaps = 42/262 (16%)
Query: 53 LQYLLQFARKPVEAESVEGVVRILLEHYYKENDPSVRLKIASLLGLLSKTAGFSPDCIMD 112
LQ L Q + E G++++ ++ S + K+A+++ ++K C+
Sbjct: 31 LQALAQNNTETSEKIQASGILQLFASLLTPQS--SCKAKVANIIAEVAKNEFMRIPCVDA 88
Query: 113 DAIN---ILQNEKSHQVLAQLLDTLLAIGTKLPENQAIQMRLVD-------VACKHLTDT 162
I+ L N K +V LL T A+G ++ ++Q +L++ V +
Sbjct: 89 GLISPLVQLLNSKDQEV---LLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLLGIHCQ 145
Query: 163 SHGVRNKCLQLLGNLGSLEKSVTKDAEGLAARDVQKIIGD---------YFSDQDPRVRT 213
+ + CL GNL LE S + A A ++ K+ F P
Sbjct: 146 NAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAEN 205
Query: 214 AAIKAMLQLHERGLK--LHQTIYNQACKLLSDDYEQVRSAAVQLIWVV------------ 259
AIK LQL E GL L + + + DD ++++ + ++ ++
Sbjct: 206 DAIK--LQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEG 263
Query: 260 --SQLYPESIVPIPSSNEEIRL 279
++ + IPS+N +++L
Sbjct: 264 GKGSVFQRVLSWIPSNNHQLQL 285
>gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4
[Homo sapiens]
Length = 559
Score = 31.2 bits (69), Expect = 4.9
Identities = 54/262 (20%), Positives = 105/262 (40%), Gaps = 42/262 (16%)
Query: 53 LQYLLQFARKPVEAESVEGVVRILLEHYYKENDPSVRLKIASLLGLLSKTAGFSPDCIMD 112
LQ L Q + E G++++ ++ S + K+A+++ ++K C+
Sbjct: 32 LQALAQNNTETSEKIQASGILQLFASLLTPQS--SCKAKVANIIAEVAKNEFMRIPCVDA 89
Query: 113 DAIN---ILQNEKSHQVLAQLLDTLLAIGTKLPENQAIQMRLVD-------VACKHLTDT 162
I+ L N K +V LL T A+G ++ ++Q +L++ V +
Sbjct: 90 GLISPLVQLLNSKDQEV---LLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLLGIHCQ 146
Query: 163 SHGVRNKCLQLLGNLGSLEKSVTKDAEGLAARDVQKIIGD---------YFSDQDPRVRT 213
+ + CL GNL LE S + A A ++ K+ F P
Sbjct: 147 NAALTEMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAEN 206
Query: 214 AAIKAMLQLHERGLK--LHQTIYNQACKLLSDDYEQVRSAAVQLIWVV------------ 259
AIK LQL E GL L + + + DD ++++ + ++ ++
Sbjct: 207 DAIK--LQLVEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEG 264
Query: 260 --SQLYPESIVPIPSSNEEIRL 279
++ + IPS+N +++L
Sbjct: 265 GKGSVFQRVLSWIPSNNHQLQL 286
>gi|157694494 MYB binding protein 1a isoform 1 [Homo sapiens]
Length = 1332
Score = 30.8 bits (68), Expect = 6.4
Identities = 43/140 (30%), Positives = 60/140 (42%), Gaps = 21/140 (15%)
Query: 28 LRLTKPSKSAALHIDLCKATSPADALQYLLQFARKPVEAESVEGVVRILLEHYYKENDPS 87
L L S AL L K SP +L F+R PV +S ++ IL++H
Sbjct: 971 LNLVTRVYSTALSSFLTKRNSPLTVPMFLSLFSRHPVLCQS---LLPILVQHI----TGP 1023
Query: 88 VRLKIASLLGLLSKTAGFSP--DCIMDDAINILQNEKSHQVLAQLLDTLLAIG---TKLP 142
VR + + L LL KT C D L QVLA++ + L +G TK
Sbjct: 1024 VRPRHQACL-LLQKTLSMREVRSCFEDPEWKQLMG----QVLAKVTENLRVLGEAQTKAQ 1078
Query: 143 ENQAI-QMRLVDV---ACKH 158
QA+ + L++V CKH
Sbjct: 1079 HQQALSSLELLNVLFRTCKH 1098
>gi|157694492 MYB binding protein 1a isoform 2 [Homo sapiens]
Length = 1328
Score = 30.8 bits (68), Expect = 6.4
Identities = 43/140 (30%), Positives = 60/140 (42%), Gaps = 21/140 (15%)
Query: 28 LRLTKPSKSAALHIDLCKATSPADALQYLLQFARKPVEAESVEGVVRILLEHYYKENDPS 87
L L S AL L K SP +L F+R PV +S ++ IL++H
Sbjct: 971 LNLVTRVYSTALSSFLTKRNSPLTVPMFLSLFSRHPVLCQS---LLPILVQHI----TGP 1023
Query: 88 VRLKIASLLGLLSKTAGFSP--DCIMDDAINILQNEKSHQVLAQLLDTLLAIG---TKLP 142
VR + + L LL KT C D L QVLA++ + L +G TK
Sbjct: 1024 VRPRHQACL-LLQKTLSMREVRSCFEDPEWKQLMG----QVLAKVTENLRVLGEAQTKAQ 1078
Query: 143 ENQAI-QMRLVDV---ACKH 158
QA+ + L++V CKH
Sbjct: 1079 HQQALSSLELLNVLFRTCKH 1098
>gi|8393009 chromosome 11 open reading frame2 [Homo sapiens]
Length = 782
Score = 30.8 bits (68), Expect = 6.4
Identities = 46/185 (24%), Positives = 76/185 (41%), Gaps = 28/185 (15%)
Query: 331 RKRTAHERAKELY--SSGEFSSGRKWGDDAPKEEVDTGAVNLIESGACGAFVHGLEDEMY 388
R+R AH K Y S GE ++GR G D P + D + + E+Y
Sbjct: 29 RRRKAHGMLKLYYGLSEGE-AAGRPAGPD-PLDPTDLNGAHF-------------DPEVY 73
Query: 389 EVRIAAVEALCMLAQSSPSFAEKCLDFLVDMFNDEIEEVR--LQSIHTMRKISNNITLRE 446
++ L L S + DM E + + T+RK+ N+ E
Sbjct: 74 LDKLRRECPLAQLMDSETDMVRQIRALDSDMQTLVYENYNKFISATDTIRKMKNDFRKME 133
Query: 447 DQLD---TVLAVLEDSSRDIREALHELLCCTNVSTKEGIHLALVELLKNLTKYPTDRDSI 503
D++D T +AV+ D S I L + ++ G+H AL+ L+ L + P+ +
Sbjct: 134 DEMDRLATNMAVITDFSARISATLQDR--HERITKLAGVH-ALLRKLQFLFELPS---RL 187
Query: 504 WKCLK 508
KC++
Sbjct: 188 TKCVE 192
>gi|90991702 leucine-rich repeat kinase 1 [Homo sapiens]
Length = 2015
Score = 30.4 bits (67), Expect = 8.3
Identities = 48/219 (21%), Positives = 90/219 (41%), Gaps = 33/219 (15%)
Query: 16 VVQPQEEIATKKLRLTKPSKSAALHIDLCKATS-------PADALQYLLQFARKPVEAES 68
VV ++ K R+ + + A + LC++ S P ++L + + K +E +
Sbjct: 754 VVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATGFPDITFKHLHEISCKSLEGQ- 812
Query: 69 VEGVVRILLEHYYKENDPSVRLKIASLLGLLSKTAGFS-PDCIM--------DDAINILQ 119
EG+ +++ D + L G L + S + ++ DD + L
Sbjct: 813 -EGLRQLIFHVTCSMKDVGSTIGCQRLAGRLIPRSYLSLQEAVLAEQQRRSRDDDVQYLT 871
Query: 120 NEKSHQVLAQLLDTLLAIGTKLPENQAIQMRLVDVACKHLTDTSHGVRN----------K 169
+ + Q++ Q D + L AI + H DTSHG+RN +
Sbjct: 872 DRQLEQLVEQTPDNDIKDYEDL--QSAISFLIETGTLLHFPDTSHGLRNLYFLDPIWLSE 929
Query: 170 CLQLLGNLGSLEKSVTKDAEGLAARDVQK-IIGDYFSDQ 207
CLQ + N+ +SV K+ + A D++ ++G F+ Q
Sbjct: 930 CLQRIFNIKG-SRSVAKNGV-IRAEDLRMLLVGTGFTQQ 966
>gi|54607053 GCN1 general control of amino-acid synthesis 1-like 1
[Homo sapiens]
Length = 2671
Score = 30.4 bits (67), Expect = 8.3
Identities = 28/113 (24%), Positives = 50/113 (44%), Gaps = 10/113 (8%)
Query: 383 LEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFLV----DMFNDEIEEVRLQSIHTMRKI 438
LE+E + + +VE L +A +P CL +V ++ D +V+ +R+I
Sbjct: 1506 LEEESWRTKAGSVELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQKAGQQALRQI 1565
Query: 439 SNNITLREDQL----DTVLAVLEDSSRDIREALHELLCCTNVSTKEGIHLALV 487
+ +R ++ +L L D SR ++ L LL V + LAL+
Sbjct: 1566 GS--VIRNPEILAIAPVLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSLALI 1616
>gi|109134349 coatomer protein complex, subunit gamma 2 [Homo
sapiens]
Length = 871
Score = 30.4 bits (67), Expect = 8.3
Identities = 45/238 (18%), Positives = 96/238 (40%), Gaps = 16/238 (6%)
Query: 27 KLRLTKPSKSAALHIDLCKATSPADALQYLLQFARKPVEAESVEGVVRIL--LEHYYKEN 84
K+ + PS A ++DL + ++ L ++ S V R++ + + E
Sbjct: 313 KVAMKHPSAVTACNLDLENLITDSNRSIATLAITTL-LKTGSESSVDRLMKQISSFVSEI 371
Query: 85 DPSVRLKIASLLGLLSKTAGFSPDCIMDDAINILQNEKSHQVLAQLLDTLLAIGTKLPEN 144
++ + + L + +M N+L+++ + ++D +++I + PE+
Sbjct: 372 SDEFKVVVVQAISALCQKYPRKHSVMMTFLSNMLRDDGGFEYKRAIVDCIISIVEENPES 431
Query: 145 QAIQMRLVDVACKHLTDTSHGV-RNKCLQLLGNLGSLEKSVTKDAEGLAARDVQKIIGDY 203
+ + + C+ + D H V K L LLG G +K + R V
Sbjct: 432 KEAGLAHL---CEFIEDCEHTVLATKILHLLGKEGPRTPVPSKYIRFIFNRVVL------ 482
Query: 204 FSDQDPRVRTAAIKAMLQLHERGLKLHQTIYNQACKLLSDDYEQVRSAAVQLIWVVSQ 261
++ VR AA+ A+ + + L +I + + D ++VR A + V+ Q
Sbjct: 483 ---ENEAVRAAAVSALAKFGAQNESLLPSILVLLQRCMMDTDDEVRDRATFYLNVLQQ 537
>gi|22027651 adaptor-related protein complex 1 beta 1 subunit
isoform a [Homo sapiens]
Length = 949
Score = 30.4 bits (67), Expect = 8.3
Identities = 43/185 (23%), Positives = 76/185 (41%), Gaps = 16/185 (8%)
Query: 84 NDPSVRLKIASLLGLLSKTAGFSPDCIMDDAINILQNEKSHQVLAQLLDTLLAIGTKLPE 143
+D + K A + S T G + D +N +Q + L +L+ L K
Sbjct: 24 SDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLE--LKKLVYLYLMNYAKSQP 81
Query: 144 NQAIQMRLVDVACKHLTDTSHGVRNKCLQLLGNLGSLEKSVTKDAEGLAARDVQKIIGDY 203
+ AI V+ K D + +R ++ +G + V K E L ++K +
Sbjct: 82 DMAIMA--VNTFVKDCEDPNPLIRALAVRTMGCI-----RVDKITEYLC-EPLRKCL--- 130
Query: 204 FSDQDPRVRTAAIKAMLQLHERGLKL--HQTIYNQACKLLSDDYEQVRSAAVQLIWVVSQ 261
D+DP VR A + +LH+ +L Q + L+SD V + AV + +++
Sbjct: 131 -KDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAE 189
Query: 262 LYPES 266
+P S
Sbjct: 190 SHPSS 194
>gi|22027653 adaptor-related protein complex 1 beta 1 subunit
isoform b [Homo sapiens]
Length = 942
Score = 30.4 bits (67), Expect = 8.3
Identities = 43/185 (23%), Positives = 76/185 (41%), Gaps = 16/185 (8%)
Query: 84 NDPSVRLKIASLLGLLSKTAGFSPDCIMDDAINILQNEKSHQVLAQLLDTLLAIGTKLPE 143
+D + K A + S T G + D +N +Q + L +L+ L K
Sbjct: 24 SDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLE--LKKLVYLYLMNYAKSQP 81
Query: 144 NQAIQMRLVDVACKHLTDTSHGVRNKCLQLLGNLGSLEKSVTKDAEGLAARDVQKIIGDY 203
+ AI V+ K D + +R ++ +G + V K E L ++K +
Sbjct: 82 DMAIMA--VNTFVKDCEDPNPLIRALAVRTMGCI-----RVDKITEYLC-EPLRKCL--- 130
Query: 204 FSDQDPRVRTAAIKAMLQLHERGLKL--HQTIYNQACKLLSDDYEQVRSAAVQLIWVVSQ 261
D+DP VR A + +LH+ +L Q + L+SD V + AV + +++
Sbjct: 131 -KDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAE 189
Query: 262 LYPES 266
+P S
Sbjct: 190 SHPSS 194
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,056,382
Number of Sequences: 37866
Number of extensions: 1547393
Number of successful extensions: 4114
Number of sequences better than 10.0: 25
Number of HSP's better than 10.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 4094
Number of HSP's gapped (non-prelim): 46
length of query: 963
length of database: 18,247,518
effective HSP length: 112
effective length of query: 851
effective length of database: 14,006,526
effective search space: 11919553626
effective search space used: 11919553626
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.