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Search of human proteins with 50083293
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50083293 coiled-coil domain containing 123 [Homo sapiens]
(783 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50083293 coiled-coil domain containing 123 [Homo sapiens] 1533 0.0
gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens] 96 1e-19
gi|46593000 GRIP1 associated protein 1 isoform 2 [Homo sapiens] 94 4e-19
gi|28416946 myosin 18A isoform a [Homo sapiens] 93 1e-18
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 91 3e-18
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 91 5e-18
gi|71061468 centromere protein E [Homo sapiens] 91 5e-18
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 89 2e-17
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 89 2e-17
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 88 3e-17
gi|42794779 myosin 18A isoform b [Homo sapiens] 88 3e-17
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 87 5e-17
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 87 6e-17
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 86 2e-16
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 85 2e-16
gi|58530840 desmoplakin isoform I [Homo sapiens] 85 3e-16
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 84 4e-16
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 84 4e-16
gi|148746195 trichohyalin [Homo sapiens] 84 5e-16
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 84 7e-16
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 83 9e-16
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 83 9e-16
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 83 9e-16
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 83 9e-16
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 82 1e-15
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 82 1e-15
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 82 2e-15
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 82 3e-15
gi|9910266 kinesin family member 15 [Homo sapiens] 82 3e-15
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 81 3e-15
>gi|50083293 coiled-coil domain containing 123 [Homo sapiens]
Length = 783
Score = 1533 bits (3968), Expect = 0.0
Identities = 783/783 (100%), Positives = 783/783 (100%)
Query: 1 MLLGFRRGRRSHFKHIIHGLLPAASVAPKAAVPRTPPPRSPNPSPERPRSALAAAILATT 60
MLLGFRRGRRSHFKHIIHGLLPAASVAPKAAVPRTPPPRSPNPSPERPRSALAAAILATT
Sbjct: 1 MLLGFRRGRRSHFKHIIHGLLPAASVAPKAAVPRTPPPRSPNPSPERPRSALAAAILATT 60
Query: 61 LTGRTVAIPQPRQRSRSESDVSSVEQDSFIEPYATTSQLRPRPNWQSEMGRRSSLPSFET 120
LTGRTVAIPQPRQRSRSESDVSSVEQDSFIEPYATTSQLRPRPNWQSEMGRRSSLPSFET
Sbjct: 61 LTGRTVAIPQPRQRSRSESDVSSVEQDSFIEPYATTSQLRPRPNWQSEMGRRSSLPSFET 120
Query: 121 LDYGDEEDIETQLSSSGKELGDVSAREDRGGHSDDLYAVPHRNQVPLLHEVNSEDDENIS 180
LDYGDEEDIETQLSSSGKELGDVSAREDRGGHSDDLYAVPHRNQVPLLHEVNSEDDENIS
Sbjct: 121 LDYGDEEDIETQLSSSGKELGDVSAREDRGGHSDDLYAVPHRNQVPLLHEVNSEDDENIS 180
Query: 181 HQDGFPGSPPAPQRTQQKDGKHPVLNLKDEKPPLCEKPPPSPDITGRARQRYTEITREKF 240
HQDGFPGSPPAPQRTQQKDGKHPVLNLKDEKPPLCEKPPPSPDITGRARQRYTEITREKF
Sbjct: 181 HQDGFPGSPPAPQRTQQKDGKHPVLNLKDEKPPLCEKPPPSPDITGRARQRYTEITREKF 240
Query: 241 EALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPE 300
EALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPE
Sbjct: 241 EALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPE 300
Query: 301 LLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWL 360
LLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWL
Sbjct: 301 LLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWL 360
Query: 361 LDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTS 420
LDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTS
Sbjct: 361 LDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTS 420
Query: 421 EEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQE 480
EEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQE
Sbjct: 421 EEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQE 480
Query: 481 KELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELME 540
KELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELME
Sbjct: 481 KELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELME 540
Query: 541 KLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMS 600
KLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMS
Sbjct: 541 KLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMS 600
Query: 601 AHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQ 660
AHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQ
Sbjct: 601 AHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQ 660
Query: 661 AALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEV 720
AALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEV
Sbjct: 661 AALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEV 720
Query: 721 IWESTFRENRRIRELLQDTLTRTGVQDNPRALVAPSLNGVSQADLLDGCDVCSYDLKSHA 780
IWESTFRENRRIRELLQDTLTRTGVQDNPRALVAPSLNGVSQADLLDGCDVCSYDLKSHA
Sbjct: 721 IWESTFRENRRIRELLQDTLTRTGVQDNPRALVAPSLNGVSQADLLDGCDVCSYDLKSHA 780
Query: 781 PTC 783
PTC
Sbjct: 781 PTC 783
>gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens]
Length = 841
Score = 96.3 bits (238), Expect = 1e-19
Identities = 119/502 (23%), Positives = 218/502 (43%), Gaps = 75/502 (14%)
Query: 238 EKFEALKEEN----MDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASS 293
++ E L EN L++ + L+ +T+ +L +++ +E+E ++LKE +
Sbjct: 66 QEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGAG 125
Query: 294 QEVAAP----ELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEG 349
A P ELL L+ EN L+ V L + KF +S+ + G
Sbjct: 126 VAQAGPLVDGELLRLQA-------ENTALQKNVAALQERYGKEAGKFSAVSEGQ-----G 173
Query: 350 LPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVK----EN 405
P GP P L+P+ LA ++ E + KEE R+ ++Q + E
Sbjct: 174 DPPGGPAPT------VLAPMPLAEVELKWEME------KEEKRLLWEQLQGLESSKQAET 221
Query: 406 EELHQELNKSSAVTS---EEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEV 462
L +EL K S E + +LQT+ + + +++ +E E+QQRK D H+ +L
Sbjct: 222 SRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIE--ELQQRKEAD-HKAQLART 278
Query: 463 SKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKS 522
KL ++L + LAE R+Q + R + H+ A++ SI + +
Sbjct: 279 QKLQQEL-------EAANQSLAELRDQRQGERLE------HAAALRALQDQVSIQS---A 322
Query: 523 QLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQK 582
Q++ E AE L L L+ + + E N L EQ L AEL++ Q
Sbjct: 323 DAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMG 382
Query: 583 KIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIK 642
+ + L Q+++++ + L + E +TQE E+ K K +
Sbjct: 383 QKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQ---------EARKSAEKRKAML 433
Query: 643 SNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQE 702
+ + L+EK + ++ A++L +++ G A+Y +E+R LH+ K ++E
Sbjct: 434 DELAMETLQEKSQHKEELGAVRL--------RHEKEVLGVRARYERELRELHEDKKRQEE 485
Query: 703 VLDQALQQNREMEGELEVIWES 724
L +++ + ELE + ++
Sbjct: 486 ELRGQIREEKARTRELETLQQT 507
Score = 88.2 bits (217), Expect = 3e-17
Identities = 139/610 (22%), Positives = 250/610 (40%), Gaps = 100/610 (16%)
Query: 137 GKELGDVSAREDR-----GGHSDDLYAVPHRNQVPLLHEVNSEDDENISHQ-DGFPGSPP 190
GKE G SA + GG + + A +V L E+ E+ + Q G S
Sbjct: 159 GKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQ 218
Query: 191 APQRTQQKDGKHPVLNLKDEKPPLCEKPPPSPDITGRARQRYTEITREKFEALKEENMDL 250
A Q++ LK ++ C + +R + E+ + K K +
Sbjct: 219 AETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLA-- 276
Query: 251 NNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEA--EKASSQEVAAPELLYLRKQA 308
Q L EL Q++ EL+ + +G E A ++ S Q A E Q
Sbjct: 277 --RTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQE------QV 328
Query: 309 QELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSP 368
+ L+ EN+ L+ ++ L ++ +T+ ++ +E++ GL ++ L
Sbjct: 329 EGLLAENNALRTSLAALE-QIQTAKTQELNMLREQTT---GLAAE------------LQQ 372
Query: 369 LLLAYEDMMKEKDELNATLKEEMRM---FRMRVQEVVKENEELHQELNKSSAVTSEEWRQ 425
YED+M +KD+LN+ L+E +R ++QE+ +E E+L QEL
Sbjct: 373 QQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQ------------ 420
Query: 426 LQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVS-KLTKQLMLLEAKTHGQEKELA 484
+A+ E+ K +L++L ++ + K H+E L V + K+++ + A+ + +EL
Sbjct: 421 ---EARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELH 477
Query: 485 ENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTV 544
E++++ E EL+ Q+ +EE+ E+E L + +
Sbjct: 478 EDKKRQE--------------------------EELRGQI-REEKARTRELETLQQTVEE 510
Query: 545 LQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQY 604
LQAQ S+ K + K E L++ Q Q++ E LK+ E+ +
Sbjct: 511 LQAQVHSMDGAKGWFERRLKEAEESLQQQQ------QEQEEALKQCREQHAAELKGKEEE 564
Query: 605 LANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALK 664
L ++ E +ERD C K + S K V + V I K +K K+Q L+
Sbjct: 565 LQDVRDQLEQAQEERD---CHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLE 621
Query: 665 LGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWES 724
+ +L E+ +D ++ R + L VL + +R G+ I
Sbjct: 622 -RKRADKLQERLQDIL-TNSKSRSGLEEL---------VLSEMNSPSRTQTGDSSSISSF 670
Query: 725 TFRENRRIRE 734
++RE R +E
Sbjct: 671 SYREILREKE 680
Score = 50.8 bits (120), Expect = 5e-06
Identities = 83/384 (21%), Positives = 154/384 (40%), Gaps = 50/384 (13%)
Query: 229 RQRYTEITREKFEALKEENMDLNNM---NQSLTLELNTMKQAMKELQLKLKGMEKEK--- 282
R RY RE E K + +L ++ T EL T++Q ++ELQ ++ M+ K
Sbjct: 466 RARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWF 525
Query: 283 -RKLKEAEKASSQEVAAPE----------LLYLRKQAQELVDENDGLKMTVHRLNVELSR 331
R+LKEAE++ Q+ E L+ + +EL D D L+ + L
Sbjct: 526 ERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKT 585
Query: 332 YQTKFRHLSKEESLNIEG---LPSKGPIPPWLLDIKYLSPLLLAYEDMMKEK-DELNATL 387
+ L +E ++G L KG L D+K L D ++E+ ++
Sbjct: 586 ISS----LKQEVKDTVDGQRILEKKGSAA--LKDLKRQLHLERKRADKLQERLQDILTNS 639
Query: 388 KEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQ 447
K + + + E+ N + SS+++S +R++ + + + L + Q
Sbjct: 640 KSRSGLEELVLSEM---NSPSRTQTGDSSSISSFSYREILREKESSAVPARSLSSSPQAQ 696
Query: 448 QRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGK 507
+ + E EV++L ++L A+T ++ L E + LE+ A E
Sbjct: 697 PPRPAELSDE---EVAELFQRL----AETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAI 749
Query: 508 IAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALE 567
I V S ++ + + + + +L++ +L E NK L+
Sbjct: 750 IETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKP-------------GDENLREMNKKLQ 796
Query: 568 AELERAQKINRKSQKKIEVLKKQV 591
LE N K +EVL +++
Sbjct: 797 NMLEEQLTKNMHLHKDMEVLSQEI 820
Score = 47.8 bits (112), Expect = 4e-05
Identities = 96/512 (18%), Positives = 201/512 (39%), Gaps = 81/512 (15%)
Query: 235 ITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQ 294
++ E+F+ ++ + ++L N L+ EL + L+ K+ ++KE K ++A S +
Sbjct: 5 LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKK 64
Query: 295 EVAAPELLYLRKQAQ-ELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSK 353
LL + Q +L + + ++ L E S+ ++ L +E EG
Sbjct: 65 AQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGA 124
Query: 354 GPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELN 413
G + PL+ ++++ + E A K V E +E
Sbjct: 125 G--------VAQAGPLVDG--ELLRLQAENTALQKN-----------VAALQERYGKEAG 163
Query: 414 KSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLE 473
K SAV+ + A VL L +L+ + K +E L +QL LE
Sbjct: 164 KFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEK---------EEKRLLWEQLQGLE 214
Query: 474 AKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHK-SIVNELKSQLQKEEEKER 532
+ + L E +L ++LK + ++ K ++ N+ ++++++ ++++
Sbjct: 215 SSKQAETSRLQEELAKLS------EKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKE 268
Query: 533 AEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEV----LK 588
A+ + + + LQ + ++ L +Q + LE A + R Q ++ + +
Sbjct: 269 ADHKAQLARTQKLQQELEAANQSLAELRDQRQG--ERLEHAAAL-RALQDQVSIQSADAQ 325
Query: 589 KQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLG 648
+QVE + + LA L + TQE L
Sbjct: 326 EQVEGLLAENNALRTSLAALEQIQTAKTQE----------------------------LN 357
Query: 649 KLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQAL 708
L E+ G + + + L+ Q++D +Q ++ +R ++L+ QE+
Sbjct: 358 MLREQTTGLAAELQQQQAEYED-LMGQKDDL---NSQLQESLRANSRLLEQLQEIG---- 409
Query: 709 QQNREMEGELEVIWESTFRENRRIRELLQDTL 740
Q+ ++ EL+ +S + + EL +TL
Sbjct: 410 QEKEQLTQELQEARKSAEKRKAMLDELAMETL 441
Score = 45.4 bits (106), Expect = 2e-04
Identities = 67/314 (21%), Positives = 124/314 (39%), Gaps = 32/314 (10%)
Query: 460 QEVSKLTKQLMLLEAKTHGQEKELAENREQLEILR----------AKCQELKTHSDGKIA 509
+E ++ QL+ L + EL +N +L LR +K Q+ + S
Sbjct: 8 EEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQE 67
Query: 510 VEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTE-------- 561
VEV S L+++L +EE R + LM + + L +Q + L E L E
Sbjct: 68 VEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGAGVA 127
Query: 562 -QNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERD 620
++ EL R Q N QK + L+++ K G ++ A G +
Sbjct: 128 QAGPLVDGELLRLQAENTALQKNVAALQERYGKEAG------KFSAVSEGQGDPPGGPAP 181
Query: 621 SLMCLAKCLESEKDGVLNKVIKSNI--RLGKLEEKVKGYKKQAALKLGDISHRLLEQQED 678
+++ E E + K K + +L LE + + +L +S +L ++QE
Sbjct: 182 TVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQES 241
Query: 679 F----AGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFR-ENRRIR 733
F K + + ++ + K+ L + ++++ ELE +S ++R
Sbjct: 242 FCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQG 301
Query: 734 ELLQDTLTRTGVQD 747
E L+ +QD
Sbjct: 302 ERLEHAAALRALQD 315
Score = 40.8 bits (94), Expect = 0.005
Identities = 78/384 (20%), Positives = 156/384 (40%), Gaps = 53/384 (13%)
Query: 385 ATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQL 444
A +EE + + ++ E+ N +L EL K+ +L K+
Sbjct: 4 ALSEEEFQRMQAQLLELRTNNYQLSDELRKNGV-------------ELTSLRQKVAYLDK 50
Query: 445 EIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEK-----------ELAENREQLEIL 493
E + + S ++ QEV L + +L+AK H QE+ E ++ Q+E L
Sbjct: 51 EFSKAQKALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQL 110
Query: 494 RAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLL 553
+ Q+LK + G + + EL +LQ E + + L E+ +A K S +
Sbjct: 111 EQENQQLKEGAAGAGVAQAGPLVDGEL-LRLQAENTALQKNVAALQERYG-KEAGKFSAV 168
Query: 554 LEKNSLTEQNKALE-------AELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLA 606
E A AE+E ++ ++ ++ + + +E + E S Q
Sbjct: 169 SEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQ--E 226
Query: 607 NLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEE-KVKGYKKQAA--- 662
L L+E + ++++S L++EK+ + N S ++ +L++ K +K Q A
Sbjct: 227 ELAKLSEKLKKKQESFC----RLQTEKETLFN---DSRNKIEELQQRKEADHKAQLARTQ 279
Query: 663 ---LKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLK----DKQEVLDQALQQNREME 715
+L + L E ++ G+ ++ +R L + D QE ++ L +N +
Sbjct: 280 KLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALR 339
Query: 716 GELEVIWESTFRENRRIRELLQDT 739
L + + + + + L + T
Sbjct: 340 TSLAALEQIQTAKTQELNMLREQT 363
>gi|46593000 GRIP1 associated protein 1 isoform 2 [Homo sapiens]
Length = 625
Score = 94.4 bits (233), Expect = 4e-19
Identities = 119/508 (23%), Positives = 221/508 (43%), Gaps = 76/508 (14%)
Query: 235 ITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQ 294
++ E+F+ ++ + ++L N L+ EL + L+ K+ ++KE K A+KA S+
Sbjct: 5 LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSK---AQKALSK 61
Query: 295 EVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELS-RYQTKFRHLSKEES--------- 344
A E+ + L+ EN+ L+ +H + + T SKE
Sbjct: 62 SKKAQEV-------EVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSA 114
Query: 345 -LNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVK 403
+G P GP P L+P+ LA ++ E + KEE R+ ++Q +
Sbjct: 115 VSEGQGDPPGGPAPT------VLAPMPLAEVELKWEME------KEEKRLLWEQLQGLES 162
Query: 404 ----ENEELHQELNKSSAVTS---EEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQ 456
E L +EL K S E + +LQT+ + + +++ +E E+QQRK D H+
Sbjct: 163 SKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIE--ELQQRKEAD-HK 219
Query: 457 ERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSI 516
+L KL ++L + LAE R+Q + R + H+ A++ SI
Sbjct: 220 AQLARTQKLQQEL-------EAANQSLAELRDQRQGERLE------HAAALRALQDQVSI 266
Query: 517 VNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKI 576
+ + Q++ E AE L L L+ + + E N L EQ L AEL++ Q
Sbjct: 267 QS---ADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAE 323
Query: 577 NRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGV 636
+ + L Q+++++ + L + E +TQE E+ K
Sbjct: 324 YEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQ---------EARKSAE 374
Query: 637 LNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQV 696
K + + + L+EK + ++ A++L +++ G A+Y +E+R LH+
Sbjct: 375 KRKAMLDELAMETLQEKSQHKEELGAVRL--------RHEKEVLGVRARYERELRELHED 426
Query: 697 LKDKQEVLDQALQQNREMEGELEVIWES 724
K ++E L +++ + ELE + ++
Sbjct: 427 KKRQEEELRGQIREEKARTRELETLQQT 454
Score = 81.3 bits (199), Expect = 3e-15
Identities = 133/599 (22%), Positives = 245/599 (40%), Gaps = 105/599 (17%)
Query: 123 YGDEEDIETQLSSS---------GKELGDVSAREDR-----GGHSDDLYAVPHRNQVPLL 168
+ EED Q S+ GKE G SA + GG + + A +V L
Sbjct: 83 HSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELK 142
Query: 169 HEVNSEDDENISHQ-DGFPGSPPAPQRTQQKDGKHPVLNLKDEKPPLCEKPPPSPDITGR 227
E+ E+ + Q G S A Q++ LK ++ C +
Sbjct: 143 WEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFND 202
Query: 228 ARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKE 287
+R + E+ + K K + Q L EL Q++ EL+ + +G E
Sbjct: 203 SRNKIEELQQRKEADHKAQLA----RTQKLQQELEAANQSLAELRDQRQGERLEHAAALR 258
Query: 288 A--EKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESL 345
A ++ S Q A E Q + L+ EN+ L+ ++ L ++ +T+ ++ +E++
Sbjct: 259 ALQDQVSIQSADAQE------QVEGLLAENNALRTSLAALE-QIQTAKTQELNMLREQTT 311
Query: 346 NIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRM---FRMRVQEVV 402
GL ++ L YED+M +KD+LN+ L+E +R ++QE+
Sbjct: 312 ---GLAAE------------LQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIG 356
Query: 403 KENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEV 462
+E E+L QEL +A+ E+ K +L++L ++ + K H+E L V
Sbjct: 357 QEKEQLTQELQ---------------EARKSAEKRKAMLDELAMETLQEKSQHKEELGAV 401
Query: 463 S-KLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELK 521
+ K+++ + A+ + +EL E++++ E EL+
Sbjct: 402 RLRHEKEVLGVRARYERELRELHEDKKRQE--------------------------EELR 435
Query: 522 SQLQKEEEKERAEMEELMEKLTVLQAQKKSL----------LLEKNSLTEQNKALEAELE 571
Q+ +EE+ E+E L + + LQAQ S+ L E E+ + + +LE
Sbjct: 436 GQI-REEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLE 494
Query: 572 RAQKINRKSQKKIEVLKKQVEKAM-GNEMSAHQYLANLVGLAENITQERDSLMCLAKCLE 630
+AQ+ K I LK++V+ + G + + A L L + ER K E
Sbjct: 495 QAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKR---ADKLQE 551
Query: 631 SEKDGVLNKVIKSNIRLGKLEEKVKGYKKQA--ALKLGDISHRLLEQQEDFAGKTAQYR 687
+D + N +S + L E + Q + + S+R + ++++ + A+ R
Sbjct: 552 RLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARVR 610
Score = 46.2 bits (108), Expect = 1e-04
Identities = 81/401 (20%), Positives = 157/401 (39%), Gaps = 61/401 (15%)
Query: 385 ATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQL 444
A +EE + + ++ E+ N +L EL K+ +L K+
Sbjct: 4 ALSEEEFQRMQAQLLELRTNNYQLSDELRKNGV-------------ELTSLRQKVAYLDK 50
Query: 445 EIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQL------EILRAKCQ 498
E + + S ++ QEV L + +L+AK H QE++ L E +
Sbjct: 51 EFSKAQKALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAG 110
Query: 499 ELKTHSDGK---------------------IAVEVHKSIVNELKSQLQKEEEKERAEMEE 537
+ S+G+ + E+ K L QLQ E ++AE
Sbjct: 111 KFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSR 170
Query: 538 LMEKLTVLQAQKKS-------LLLEKNSLTEQNKALEAELERAQKINRKSQ-KKIEVLKK 589
L E+L L + K L EK +L ++ EL++ ++ + K+Q + + L++
Sbjct: 171 LQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQ 230
Query: 590 QVEKAMGNEMSAH---QYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIR 646
++E A N+ A Q + A + +D + + + + +G+L +
Sbjct: 231 ELEAA--NQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTS 288
Query: 647 LGKLEEKVKGYKKQAALKLGD----ISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQE 702
L LE+ ++ K Q L + ++ L +QQ ++ Q L + L+
Sbjct: 289 LAALEQ-IQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSR 347
Query: 703 VLDQAL---QQNREMEGELEVIWESTFRENRRIRELLQDTL 740
+L+Q Q+ ++ EL+ +S + + EL +TL
Sbjct: 348 LLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETL 388
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 92.8 bits (229), Expect = 1e-18
Identities = 133/536 (24%), Positives = 240/536 (44%), Gaps = 58/536 (10%)
Query: 255 QSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPELLYLRKQAQE---L 311
Q LT EL K ++ Q++ +EK++R+ ++E + + E A E L K +E L
Sbjct: 1433 QRLTAELQDTKLHLEGQQVRNHELEKKQRRF-DSELSQAHEEAQREKLQREKLQREKDML 1491
Query: 312 VDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLL 371
+ E LK + +++++ + K L E +I SK + K L L
Sbjct: 1492 LAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQ-DISSQESKDEASLAKVK-KQLRDLEA 1549
Query: 372 AYEDMMKEKDELNAT--------LKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEW 423
+D +E DE T L+ EM M RMR Q KE E +E+ ++ ++
Sbjct: 1550 KVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMR-QTHSKEMESRDEEVEEARQSCQKKL 1608
Query: 424 RQLQTQAKLVLEEN-KLLLEQLEIQQRKAKDSHQ---------ERLQEVSKLTK------ 467
+Q++ Q + E+ K+L E+ E++ + A S Q +RL++ K TK
Sbjct: 1609 KQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADA 1668
Query: 468 QLMLLEAKTHGQEK-ELAENREQLEILRAKCQE-LKTHSDGKIAVE-VH---------KS 515
QLML K K E+A+ + QLE C +K ++ +E +H K+
Sbjct: 1669 QLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKT 1728
Query: 516 IVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQK 575
+ E S+LQ+E+ + + +EE E + L + K+ + + + Q L+A+LE A K
Sbjct: 1729 ALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANK 1788
Query: 576 INRKSQKKIEVLKKQV---EKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESE 632
++ Q+K++ L+ QV E++M ++ + A + L + ER + L
Sbjct: 1789 EKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRL 1848
Query: 633 KDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRH 692
K+ + K+ + + E + K K+ +L D E+ + A K A+ ++
Sbjct: 1849 KEN-MEKLTEERDQRIAAENREKEQNKRLQRQLRDTK----EEMGELARKEAEASRKKHE 1903
Query: 693 LHQVLKDKQEVLDQALQQNREME----GELEVIWESTFR--ENRRIRELLQDTLTR 742
L L + E +Q+LQ + ++ G+L+ E EN + LQD +T+
Sbjct: 1904 LEMDL-ESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTK 1958
Score = 61.2 bits (147), Expect = 3e-09
Identities = 86/440 (19%), Positives = 181/440 (41%), Gaps = 67/440 (15%)
Query: 358 PWLLDIKYLSPLLLAY--EDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKS 415
PW + PL+ E+ ++ KDE E++ R ++++ KE EL ++
Sbjct: 1235 PWWKLFTTVRPLIEVQLSEEQIRNKDE-------EIQQLRSKLEKAEKERNELRLNSDRL 1287
Query: 416 SAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAK 475
+ SE +L T + E LL+ ++ +A+ +E + L KQ+ ++E +
Sbjct: 1288 ESRISELTSEL-TDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEME 1346
Query: 476 TH-------------------GQEKELAENREQLEILRAKCQELKTHSDGKIAVEV-HKS 515
G E L R E+ K + L+ + K+ VE +K
Sbjct: 1347 VMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTK-KRLQQEFEDKLEVEQQNKR 1405
Query: 516 IVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLE-------KNSLTEQNKALEA 568
+ LQ + E+ + +++L +K L A+ + L + L ++ + ++
Sbjct: 1406 QLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDS 1465
Query: 569 ELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLA----NLVGLAENITQERDSLMC 624
EL +A + ++ + + E L+++ + + S Q L ++ G + + L
Sbjct: 1466 ELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQD 1525
Query: 625 LAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDI---------------- 668
++ ES+ + L KV K +L LE KVK +++ + G I
Sbjct: 1526 ISS-QESKDEASLAKVKK---QLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMER 1581
Query: 669 -----SHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWE 723
S + + E+ +++++ + L+++ E + L++ RE+EG+L + +
Sbjct: 1582 MRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSD 1641
Query: 724 STFRENRRIRELLQDTLTRT 743
R + + L+ L RT
Sbjct: 1642 QVNRRDFESEKRLRKDLKRT 1661
Score = 40.4 bits (93), Expect = 0.006
Identities = 78/341 (22%), Positives = 134/341 (39%), Gaps = 65/341 (19%)
Query: 230 QRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKEL------QLKLKGMEKEKR 283
++ + + REK E D +MN+ + + QA ++L Q +L+ KEK+
Sbjct: 1732 EQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQ 1791
Query: 284 KLKEAEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEE 343
+L+E +A +V E Q +VD++ +SR + K R L E
Sbjct: 1792 ELQEKLQALQSQVEFLE--------QSMVDKS------------LVSRQEAKIREL--ET 1829
Query: 344 SLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEM-RMFRMRVQEVV 402
L E +K + L + LKE M ++ R Q +
Sbjct: 1830 RLEFE-------------------------RTQVKRLESLASRLKENMEKLTEERDQRIA 1864
Query: 403 KENEELHQ--ELNKSSAVTSEEWRQL---QTQAKLVLEENKLLLEQLEIQQRKAKDSHQE 457
EN E Q L + T EE +L + +A E ++ LE LE A S Q
Sbjct: 1865 AENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLE----AANQSLQA 1920
Query: 458 RLQEVSKLTKQLM-LLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSI 516
L+ K L +E + E E N Q + + + ++ K D + E+ +
Sbjct: 1921 DLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKRKNKLEGDSDVDSEL-EDR 1979
Query: 517 VNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKN 557
V+ +KS L K + +A ++ K + + KSL +++
Sbjct: 1980 VDGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLAPDRS 2020
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 91.3 bits (225), Expect = 3e-18
Identities = 119/482 (24%), Positives = 219/482 (45%), Gaps = 45/482 (9%)
Query: 167 LLHEVNSEDDENISHQDGFPGSPPAPQRTQQKDGKHPVLNLKDEKPPLCEKPPPSPDITG 226
L+ E+++ D+ D S ++ QK GK +L+L+ L + + T
Sbjct: 851 LMTELSTVKDKLSKVSDSLKNSKSEFEKENQK-GKAAILDLEKTCKELKHQLQVQMENTL 909
Query: 227 RARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQL------KLKGMEK 280
+ ++ + ++ EA + ++LN+M + L NT+KQ KE Q +LK +
Sbjct: 910 KEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSE 969
Query: 281 EKRKLKEAEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLS 340
+K+K EA + + + K Q+L L +++V + Y+ K +
Sbjct: 970 QKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYE-KSQETF 1028
Query: 341 KEESLNIEGLPSKGPIPPWLLDIKYLSPLL-LAYEDMMKEKDELNATLKEEMRMFRMRVQ 399
K+ + G S+ + D+K + L LA ED++ ++++ K +Q
Sbjct: 1029 KQLQSDFYGRESE--LLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNK--------LIQ 1078
Query: 400 EVVKENEELHQELNKSSAVTSEEWRQLQT-QAKLVLEENKLLLEQLEIQQRKAKDSHQER 458
E+ L Q+ K E + LQ Q + L+E +L+ E+ ++ + + QE+
Sbjct: 1079 ELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEK 1138
Query: 459 LQEVSKLTKQLMLLEAKTHGQE--KELAENREQLEILRAKCQELKTHSDG-KIAVEVHKS 515
E++KL ++L K+H E KE+ ++ ++L + EL+ +D K AVE K
Sbjct: 1139 --EITKLNEEL-----KSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKR 1191
Query: 516 IVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKN-----SLTEQNKALEAEL 570
LK Q++KEEE+ + E E KL + ++K + ++K+ LT Q AL L
Sbjct: 1192 NQQILKDQVKKEEEELKKEFIEKEAKLH-SEIKEKEVGMKKHEENEAKLTMQITALNENL 1250
Query: 571 ERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLE 630
+K + SQ+++ L+KQ + G +A L +N ER +L L +CL+
Sbjct: 1251 GTVKKEWQSSQRRVSELEKQTDDLRGE-------IAVLEATVQNNQDERRAL--LERCLK 1301
Query: 631 SE 632
E
Sbjct: 1302 GE 1303
Score = 78.2 bits (191), Expect = 3e-14
Identities = 132/645 (20%), Positives = 267/645 (41%), Gaps = 86/645 (13%)
Query: 194 RTQQKDGKHPVLN--------LKDEKPPLCEKPPPSPDITGRARQRYTEITREK---FEA 242
+ Q +G+ VLN L+++ L EK + +A++ + +E+ A
Sbjct: 552 KIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRA 611
Query: 243 LKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPELL 302
++ + L L +LN K+ + +L +++K K +L + +A+ A
Sbjct: 612 AQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKA----KTELLLSAEAAKTAQRADLQN 667
Query: 303 YLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLS---------KEESLNIEGLPSK 353
+L L D+ L +L+ ++ Q K H S KE+ L++E +
Sbjct: 668 HLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEE 727
Query: 354 --GPIPPWLLD-IKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQ 410
G I D ++ + A +D+ +++ +LN L+ +R E+ K+ E + +
Sbjct: 728 LEGQIKKLEADSLEVKASKEQALQDLQQQR-QLNTDLE-------LRATELSKQLE-MEK 778
Query: 411 ELNKSSAVT----SEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLT 466
E+ S+ + SE ++ + EE ++L + E ++ K H+E +
Sbjct: 779 EIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTV 838
Query: 467 KQLMLLEAKTHGQEKELAENREQLE-----ILRAKCQELKTHSDGKIAVEVHKSIVNELK 521
+L ++ + EL+ +++L + +K + K + GK A+ + ELK
Sbjct: 839 TELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELK 898
Query: 522 SQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQ 581
QLQ + E E +EL + L + L LE NS+ EQ + L++ +K ++ Q
Sbjct: 899 HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQ 958
Query: 582 KKIEVL-------KKQVEKAMGNEMSA--------HQYLANLVGLAENITQERDSLMCLA 626
I L KKQ+E G A ++ L A+ + E++ + L
Sbjct: 959 GNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQ 1018
Query: 627 ----------KCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDI--SHRLLE 674
K L+S+ G ++++ + L +EEK+ ++ I ++L++
Sbjct: 1019 NNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ 1078
Query: 675 Q--------QEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTF 726
+ ++D A K Q ++ + L + K+K + ++ L + E+E I
Sbjct: 1079 ELKTAKATLEQDSAKKEQQLQERCKALQDIQKEK-SLKEKELVNEKSKLAEIEEIKCRQE 1137
Query: 727 RENRRIRE-----LLQDTLTRTGVQDNPRALVAPSLNGVSQADLL 766
+E ++ E L+ T ++D + L+ L +AD L
Sbjct: 1138 KEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSL 1182
Score = 70.9 bits (172), Expect = 4e-12
Identities = 120/615 (19%), Positives = 244/615 (39%), Gaps = 104/615 (16%)
Query: 238 EKFEALKEENMDLNNMNQSLTLELNT----MKQAMKELQLKLKGMEKEKRKLKEAEKASS 293
E LK+E + + + ++TLE +K K+LQ + E +L+
Sbjct: 221 EDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGP 280
Query: 294 QEVAA--PELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLP 351
QEVA EL L+ EL +N L + ++ + TK EES++ + +
Sbjct: 281 QEVAVYVQELQKLKSSVNELTQKNQTLTENL----LKKEQDYTKLEEKHNEESVSKKNI- 335
Query: 352 SKGPIPPWLLDIKYLSPLLLAYEDMM-------KEKDELNATLKEEMRMFRMRVQEVVKE 404
+ + LD + L L A E + EK E LKEE+ + Q + E
Sbjct: 336 -QATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAE 394
Query: 405 NEELHQ--------------ELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQL------ 444
++L Q E+N+ + E RQL + E+ +L E+L
Sbjct: 395 FKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQ 454
Query: 445 -----------------------EIQQR--KAKDSHQER--------------LQEVSKL 465
E+Q + K K HQE+ ++ ++
Sbjct: 455 VADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQV 514
Query: 466 TKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTH---SDGKIAV------------ 510
+Q+ + K E L +++E + +L + ++L +G+ AV
Sbjct: 515 LRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQ 574
Query: 511 EVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAEL 570
E + +LK+Q + ++ + +++ E+ L+A + +L + S+ E N L
Sbjct: 575 EQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESK 634
Query: 571 ERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLE 630
E+ +++ + + K E+L A + + L N + A+N Q++ + +
Sbjct: 635 EKVSQLDIQIKAKTELLL----SAEAAKTAQRADLQNHLDTAQNALQDKQQEL---NKIT 687
Query: 631 SEKDGVLNKVIKSNIRLGKLEEKVKGYKKQ---AALKLGDISHRLLEQQEDFAGKTAQYR 687
++ D V K+ +LE +K YK++ K ++ ++ + + D A
Sbjct: 688 TQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKE 747
Query: 688 QEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDTLTRTGVQD 747
Q ++ L Q + ++ +A + ++++E E E++ ST + ++ E L+ + Q+
Sbjct: 748 QALQDLQQQRQLNTDLELRATELSKQLEMEKEIV-SSTRLDLQKKSEALESIKQKLTKQE 806
Query: 748 NPRALVAPSLNGVSQ 762
+ ++ +SQ
Sbjct: 807 EEKQILKQDFETLSQ 821
Score = 36.2 bits (82), Expect = 0.12
Identities = 69/324 (21%), Positives = 134/324 (41%), Gaps = 66/324 (20%)
Query: 477 HGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQK------EEEK 530
HG E LA R+ + +LR + Q+L+ +++ K ELK +L+K +E K
Sbjct: 72 HGGESNLALKRDDVTLLRQEVQDLQA------SLKEEKWYSEELKKELEKYQGLQQQEAK 125
Query: 531 -------ERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAEL---------ERA- 573
AE++ L ++L Q + ++ K+ ++ L E+ ER+
Sbjct: 126 PDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSL 185
Query: 574 -----QKINR------KSQKKIEVLKKQVEKAMGNEMSA--HQYLANLVGLAENITQER- 619
QK+ R K I+ LK ++ + G E A + L + L +N+T ER
Sbjct: 186 REAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERE 245
Query: 620 ---DSLMCLAKCLESE---KDGVLNKVIKSNIRLGKLE--------EKVKGYKKQAALKL 665
+ L K L+S+ + +++ ++S + G E +K+K + K
Sbjct: 246 RESEKLKDECKKLQSQYASSEATISQ-LRSELAKGPQEVAVYVQELQKLKSSVNELTQKN 304
Query: 666 GDISHRLLEQQEDFAGKTAQYRQE-------MRHLHQVLKDKQEVLDQALQQNREMEGEL 718
++ LL++++D+ ++ +E LHQ D Q+ L L + +
Sbjct: 305 QTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQ-LQSRLSASETSLHRI 363
Query: 719 EVIWESTFRENRRIRELLQDTLTR 742
V ++++E L + T+
Sbjct: 364 HVELSEKGEATQKLKEELSEVETK 387
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 90.5 bits (223), Expect = 5e-18
Identities = 116/556 (20%), Positives = 236/556 (42%), Gaps = 72/556 (12%)
Query: 235 ITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQ 294
I E+ +A E + M L + +++ + +L+ +++ E+ + L+ +K
Sbjct: 891 ILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQA 950
Query: 295 EVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKG 354
+ + +E +DE +G + +L +E + K + + +EE L +E SK
Sbjct: 951 HI---------QDLEEQLDEEEGARQ---KLQLEKVTAEAKIKKM-EEEILLLEDQNSK- 996
Query: 355 PIPPWLLDIKYLSPLLLAYEDMMKEKDELN---ATLKEEMRMFRMRVQEVVKENEELHQE 411
++ + K + + + E++E A ++ + + ++E +K+ E+ QE
Sbjct: 997 ----FIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQE 1052
Query: 412 LNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQ--------------E 457
L K+ E LQ Q + E + +++L++Q K ++ Q
Sbjct: 1053 LEKAKRKLDGETTDLQDQ----IAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNN 1108
Query: 458 RLQEVSKLTKQLMLLE-------AKTHGQEKELAENREQLEILRAKC----------QEL 500
L+ V +L Q+ L+ A + EK+ + E+LE L+ + QEL
Sbjct: 1109 ALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQEL 1168
Query: 501 KTHSDGKIAVEVHKSIVNELKS---QLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKN 557
+T + ++A E+ K++ E K+ Q+Q ++ +EEL E+L + K +L K
Sbjct: 1169 RTKREQEVA-ELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQ 1227
Query: 558 SLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQ 617
L NK L E++ Q++ +S+ K + L QV++ + L A +
Sbjct: 1228 GLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQN 1287
Query: 618 ERDSLMCLAKCLESEKDGV--------LNKVIKSNIRLGKLEEKVKGYKKQAALKLGDIS 669
E D++ L + E+EK G+ L ++ L + E + K +L +
Sbjct: 1288 ELDNVSTLLE--EAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEK 1345
Query: 670 HRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFREN 729
+ L EQQE+ +++ L L D ++ +D L +E + + + +
Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405
Query: 730 RRIRE--LLQDTLTRT 743
+R+ E L D L +T
Sbjct: 1406 QRLEEKALAYDKLEKT 1421
Score = 82.4 bits (202), Expect = 1e-15
Identities = 120/520 (23%), Positives = 223/520 (42%), Gaps = 55/520 (10%)
Query: 241 EALKEEN---MDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVA 297
E LK+E +L + L E ++ + ELQ ++ ++ KL+ A+K + A
Sbjct: 1041 ERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQI-----DELKLQLAKKEEELQGA 1095
Query: 298 APELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIP 357
L + E + +N+ LK+ V L +++ Q F E++ + K +
Sbjct: 1096 ------LARGDDETLHKNNALKV-VRELQAQIAELQEDFE---SEKASRNKAEKQKRDLS 1145
Query: 358 PWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSA 417
+++ L L D + EL ++E+ + ++E K +E Q++ + A
Sbjct: 1146 E---ELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHA 1202
Query: 418 VTSEEWRQLQTQAKLV---LEENK---------LLLEQLEIQQRKAKDSHQERLQEVSKL 465
EE + QAK LE+NK L E +QQ KA+ H+ + KL
Sbjct: 1203 TALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRK-----KL 1257
Query: 466 TKQLMLLEAKTHGQEK---ELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKS 522
Q+ L AK ++ ELAE +L+ L ++ K ++ K + L+S
Sbjct: 1258 DAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKK-GIKFAKDAAS-LES 1315
Query: 523 QLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQK 582
QLQ +E + EE +KL L ++ + L EKNSL EQ + E + +K Q
Sbjct: 1316 QLQDTQELLQ---EETRQKLN-LSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQS 1371
Query: 583 KIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIK 642
++ KK+V+ +G S + L+ AE ++Q + LE K+ + ++
Sbjct: 1372 QLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDD 1431
Query: 643 SNIRL-------GKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQ 695
+ L LE+K K + Q + IS R E+++ + + + L +
Sbjct: 1432 LTVDLDHQRQVASNLEKKQKKF-DQLLAEEKSISARYAEERDRAEAEAREKETKALSLAR 1490
Query: 696 VLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIREL 735
L++ E ++ +QN+++ ++E + S + + EL
Sbjct: 1491 ALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHEL 1530
Score = 77.4 bits (189), Expect = 5e-14
Identities = 126/599 (21%), Positives = 243/599 (40%), Gaps = 116/599 (19%)
Query: 198 KDGKHPVLNLKDEKPPLCEKPPPSPDITGRARQRYTEIT--REKFEALKEENMDLNNMNQ 255
KD L+D + L E+ +++ R RQ E +E+ E +E +L
Sbjct: 1308 KDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVL 1367
Query: 256 SLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPELLYLRKQAQELVDEN 315
+L +L K+ + + ++ +E+ K+KL + +A SQ + L Y
Sbjct: 1368 ALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY------------ 1415
Query: 316 DGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYED 375
D L+ T +RL EL H ++ + N+E K ++
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDH-QRQVASNLEKKQKK-------------------FDQ 1455
Query: 376 MMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLE 435
++ E+ ++A EE R R + +E E L ++ LE
Sbjct: 1456 LLAEEKSISARYAEE----RDRAEAEAREKETKALSLARA------------------LE 1493
Query: 436 ENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRA 495
E E+ E Q ++ + ++ + + K + LE E+++ E R QLE L
Sbjct: 1494 EALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELE- 1552
Query: 496 KCQELKTHSDGKIAVEVHKSIVN-----ELKSQLQKEEEKERAEMEELMEKLTVLQAQKK 550
EL+ D K+ +EV+ + +L+++ ++ EEK+R ++++ E L+ ++K
Sbjct: 1553 --DELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERK 1610
Query: 551 SLLL---EKNSLTEQNKALEAELERAQKIN-------RKSQKKIEVLKKQVEKAMGN--- 597
L K + K LEA++E A K RK Q +++ ++++E+A +
Sbjct: 1611 QRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDE 1670
Query: 598 --------EMSAHQYLANLVGLAENIT----------QERDSLMCLAKCLESEKDGVLNK 639
E A ++ L E + QERD L S K +L++
Sbjct: 1671 IFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDE 1730
Query: 640 VIKSNIRLGKLEEKVKGYKKQAALKL-----------GDISHRLLEQQEDFAGKTAQYRQ 688
+ R+ +LEE+++ ++Q+ ++L D + L + A K+ RQ
Sbjct: 1731 KRRLEARIAQLEEELE--EEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQ 1788
Query: 689 EMRHLHQVLKDKQEVLDQALQQNREME--------GELEVIWESTFRENRRIRELLQDT 739
++ ++ LK K + L+ A++ + G+LE E +E +L++ T
Sbjct: 1789 QLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRT 1847
Score = 67.4 bits (163), Expect = 5e-11
Identities = 79/367 (21%), Positives = 165/367 (44%), Gaps = 47/367 (12%)
Query: 399 QEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQER 458
+E+ ++EEL + K + V E +++ + + +LEE +L EQL+ + ++ + R
Sbjct: 852 EELQAKDEELLKVKEKQTKVEGE-LEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910
Query: 459 LQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVN 518
++L + LE H E + E E+ +IL+ + ++++ H +E
Sbjct: 911 ----ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQD---LEEQLDEEE 963
Query: 519 ELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEK----NSLTEQNKALEAELERAQ 574
+ +LQ E+ A+++++ E++ +L+ Q + EK + + E + L E E+A+
Sbjct: 964 GARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAK 1023
Query: 575 KINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKD 634
+ K + K EV+ +E+ + E Q L + T + L+ +
Sbjct: 1024 NL-AKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTD----------LQDQIA 1072
Query: 635 GVLNKVIKSNIRLGKLEEKVKG----------YKKQAALKLGDISHRLLEQQEDFAGKTA 684
+ ++ + ++L K EE+++G +K A + ++ ++ E QEDF + A
Sbjct: 1073 ELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKA 1132
Query: 685 -------QYRQEMRHLHQVLKDKQEVLD-----QALQQNREME-GEL-EVIWESTFRENR 730
Q R L + + ++ LD Q L+ RE E EL + + E T
Sbjct: 1133 SRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEA 1192
Query: 731 RIRELLQ 737
+I+++ Q
Sbjct: 1193 QIQDMRQ 1199
Score = 59.3 bits (142), Expect = 1e-08
Identities = 98/486 (20%), Positives = 192/486 (39%), Gaps = 118/486 (24%)
Query: 373 YEDMMKEKDELNATLKEEMRMF------RMRVQEVVKENEELHQELNKSSAVTSEEWRQL 426
++ +++EK+ L L+ E +F R R+ +E EE+ +L E + L
Sbjct: 882 HQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQIL 941
Query: 427 QTQAKLVLEENKLLLEQLEIQQRKAKDSHQERL---QEVSKLTKQLMLLE---------- 473
Q + K + + L EQL+ ++ + E++ ++ K+ ++++LLE
Sbjct: 942 QNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEK 1001
Query: 474 --------------AKTHGQEKELAENREQLEIL--------------RAKCQELKTHSD 505
A+ + K LA+ R + E++ R + ++ K D
Sbjct: 1002 KLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLD 1061
Query: 506 GKIA-----VEVHKSIVNELKSQLQKEEE------------------------KERAEME 536
G+ + ++ ++ELK QL K+EE + +A++
Sbjct: 1062 GETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIA 1121
Query: 537 ELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELE-------RAQKINRKSQKKIEVLKK 589
EL E +A + +K L+E+ +AL+ ELE Q++ K ++++ LKK
Sbjct: 1122 ELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKK 1181
Query: 590 QVEKAMGN-----------------EMS-----AHQYLANLVGLAENITQERDSLMCLAK 627
+E+ N E+S A ++ ANL + + + L C K
Sbjct: 1182 ALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVK 1241
Query: 628 CLESEKDGVLNKVIKSNIRLGKLEEKVKGYKK------QAALKLGDISHRLLEQQEDFAG 681
L+ K +K K + ++ +L KV + + A KL + + E+
Sbjct: 1242 VLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEK 1301
Query: 682 KTAQYRQEMRHLHQVLKDKQEVLDQALQQN-------REMEGELEVIWESTFRENRRIRE 734
K ++ ++ L L+D QE+L + +Q R++E E + E E +
Sbjct: 1302 KGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKN 1361
Query: 735 LLQDTL 740
L + L
Sbjct: 1362 LEKQVL 1367
Score = 59.3 bits (142), Expect = 1e-08
Identities = 80/353 (22%), Positives = 150/353 (42%), Gaps = 45/353 (12%)
Query: 244 KEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPELLY 303
K+ +DL ++ + + +K+L+ M+ +R+L+EA +AS E+ A
Sbjct: 1620 KKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEA-RASRDEIFA----- 1673
Query: 304 LRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDI 363
Q++E + L+ + +L EL+ + RH +E + + + LLD
Sbjct: 1674 ---QSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDE 1730
Query: 364 KYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEW 423
K +A + E+++ N L + FR +V N EL E +S+A S+
Sbjct: 1731 KRRLEARIAQLEEELEEEQSNMELLNDR--FRKTTLQVDTLNAELAAE--RSAAQKSDNA 1786
Query: 424 RQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEV-SKLTKQLMLLEAKTHGQEKE 482
RQ QLE Q ++ K QE V SK + LEAK E++
Sbjct: 1787 RQ-----------------QLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQ 1829
Query: 483 LAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELK--SQLQKEEEKERAEMEELME 540
L + ++ RA +L ++ K+ E+ + +E + Q +++ EK A M++L
Sbjct: 1830 LEQEAKE----RAAANKLVRRTEKKLK-EIFMQVEDERRHADQYKEQMEKANARMKQLKR 1884
Query: 541 KLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEK 593
+L + E + L+ EL+ A + N +++ LK ++ +
Sbjct: 1885 QLEEAEE-------EATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930
Score = 57.8 bits (138), Expect = 4e-08
Identities = 79/358 (22%), Positives = 157/358 (43%), Gaps = 50/358 (13%)
Query: 422 EWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEK 481
+W ++ T+ K +L+ + + ++ +AKD +E L+ K TK LE ++
Sbjct: 833 QWWRVFTKVKPLLQVTR------QEEELQAKD--EELLKVKEKQTKVEGELEEMERKHQQ 884
Query: 482 ELAENR---EQLEI---LRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEE------ 529
L E EQL+ L A+ +E++ K + + I+++L+S++++EEE
Sbjct: 885 LLEEKNILAEQLQAETELFAEAEEMRARLAAK--KQELEEILHDLESRVEEEEERNQILQ 942
Query: 530 ----KERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIE 585
K +A +++L E+L + ++ L LEK + + K +E E+ + N K K+ +
Sbjct: 943 NEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKK 1002
Query: 586 VLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNI 645
+++ ++ + LA A+N+ + R+ + LE L K K+
Sbjct: 1003 LMEDRIAECSSQ-------LAEEEEKAKNLAKIRNKQEVMISDLEER----LKKEEKTRQ 1051
Query: 646 RLGKLEEKVKGYK-------KQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLK 698
L K + K+ G + ++ ++ +L +++E+ G A+ E H + LK
Sbjct: 1052 ELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALK 1111
Query: 699 DKQEVLDQALQQNREMEGE------LEVIWESTFRENRRIRELLQDTLTRTGVQDNPR 750
+E+ Q + + E E E E ++ L+DTL T Q R
Sbjct: 1112 VVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELR 1169
Score = 49.3 bits (116), Expect = 1e-05
Identities = 70/416 (16%), Positives = 168/416 (40%), Gaps = 47/416 (11%)
Query: 234 EITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASS 293
E+ + K AL+++ ++ + L EL + A L++ ++ M+ + + + +
Sbjct: 1529 ELEKSK-RALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQN 1587
Query: 294 QEVAAPELLYLRKQAQELVDENDGLKMTV---HRLNVELSRYQTKFRHLSKEESLNIEGL 350
+E + +R+ EL DE + V ++ ++L + + +K I+ L
Sbjct: 1588 EEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQL 1647
Query: 351 PSKGPIPPWLLDIKYLSPLLLAYEDMMKE----KDELNATLKEEMRMFRMRVQEVVK--- 403
+ L + Y+ ++E +DE+ A KE + + E+++
Sbjct: 1648 -------------RKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQE 1694
Query: 404 --------------ENEELHQELNKSSAVTS---EEWRQLQTQAKLVLEENKLLLEQLEI 446
E +EL E+ S++ S +E R+L+ + + EE LE+ +
Sbjct: 1695 ELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEE----LEEEQS 1750
Query: 447 QQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDG 506
D ++ +V L +L + + + Q + L+AK QEL+
Sbjct: 1751 NMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKS 1810
Query: 507 KIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKAL 566
K + S + QL+++ E+E E + + + + K + ++
Sbjct: 1811 KFKATI--SALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQY 1868
Query: 567 EAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSL 622
+ ++E+A ++ ++++E +++ +A + + L + E +++E +L
Sbjct: 1869 KEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTL 1924
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 90.5 bits (223), Expect = 5e-18
Identities = 126/603 (20%), Positives = 260/603 (43%), Gaps = 105/603 (17%)
Query: 195 TQQKDGKHPVLNLKDEKPPLCEKPPPSPDITGRARQRYTEITREKFEALKEENMDLNNMN 254
TQ + H L++E P L E+ P++ + T+ T + E L E++ ++
Sbjct: 1268 TQDLEKSHT--KLQEEIPVLHEEQELLPNVKEVSE---TQETMNELELLTEQSTTKDSTT 1322
Query: 255 QS-LTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPELLYLRKQAQELVD 313
+ + +E + + +E Q ++K + KE+ LK ++A L
Sbjct: 1323 LARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEA-------------------LEV 1363
Query: 314 ENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAY 373
++D LK + ++ Q+K +E+SLN++ ++ + +++
Sbjct: 1364 KHDQLKEHIRETLAKIQESQSK-----QEQSLNMKEKDNE-------------TTKIVSE 1405
Query: 374 EDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQE---LNKSSAVTSEEWRQLQTQA 430
+ K KD ++ EM R+QE E + + +E L + V E QL+
Sbjct: 1406 MEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENI 1465
Query: 431 KLVLEENKLLLEQLEIQQRKAKDSHQ----------ERLQEVSKLTKQLMLLEAKTHGQE 480
K ++ ++ E+L++ K+ + E+ E+S + KQL + K +
Sbjct: 1466 KEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKI 1525
Query: 481 KELAENREQLEI-----LRAKCQELKTHSDGK----IAVEVHKSIVNELKSQLQKEEEKE 531
+E+ E EQ I ++ K ELK + + A++ +S + EL ++LQ+ +E+
Sbjct: 1526 QEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEI 1585
Query: 532 RAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQK----------INRKSQ 581
+ ++E E V +A L +E++ L E K + A+++ +Q+ +N +
Sbjct: 1586 QIMIKEKEEMKRVQEA----LQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQE 1641
Query: 582 K--KIEVLKKQVEKAMGN-------EMSAHQYLANLVGLAENITQERDSLMCLAKCLESE 632
K +IE LK+Q E N + Q L + ++T+ERD L + + L+ E
Sbjct: 1642 KMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVE 1701
Query: 633 KDGVLNKVIKSNIR-LGKLEE----------------KVKGYKKQAALKLGDISHRLLEQ 675
+D + + ++ R L K EE K++G + ++ ++ L
Sbjct: 1702 RDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHS 1761
Query: 676 QEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIREL 735
+ + + ++E+R H LK++QE +D+ E +L + + N +++E
Sbjct: 1762 NDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEK 1821
Query: 736 LQD 738
+Q+
Sbjct: 1822 IQE 1824
Score = 78.6 bits (192), Expect = 2e-14
Identities = 166/757 (21%), Positives = 311/757 (41%), Gaps = 144/757 (19%)
Query: 78 ESDVSSV--EQDSFIEPYATTSQLRP-RPNWQSEMGRRSSLPSFETLDYGDEEDIETQLS 134
ES+++S+ + D+ + Y QLR + + ++ ++ L FE L+ ++D E QL
Sbjct: 497 ESELNSLRADYDNLVLDY---EQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLI 553
Query: 135 SSGKEL------GDVSAREDRGGHSDDLYAVPHR-NQVPLLHE-VNSEDDENISHQDGFP 186
L +V ++ S + + + +Q+ L E ++S+ ENI +
Sbjct: 554 HEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYS 613
Query: 187 -GSPPAPQRTQQK---------DGKHPVLNLKDEKPPLCEKPPPSPDITGRARQRYTEIT 236
S P++ +Q D K L+ E L EK T + + ++
Sbjct: 614 LESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELAT-TYKQMENDIQLY 672
Query: 237 REKFEALKEENMDLNNMNQSLTLELNTMKQAMK-----------ELQLKLKGMEKEKRKL 285
+ + EA K+ +DL QS E+ + + EL+ K+ ++KE K
Sbjct: 673 QSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKE 732
Query: 286 KEAEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKE-ES 344
E +A +EV L+ E L V RL E+ + ++ E +
Sbjct: 733 VEENEALREEVI-------------LLSELKSLPSEVERLRKEIQDKSEELHIITSEKDK 779
Query: 345 LNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKE 404
L E + + + L +I L + K D+ K F + + V++E
Sbjct: 780 LFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEE 839
Query: 405 NEELHQE--------------LNKSSAVTSEEWRQLQTQAKLV---LEENKLLLEQLEIQ 447
NE ++QE L S + ++LQ + + V L E + L EQLE +
Sbjct: 840 NERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENR 899
Query: 448 QRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEK-ELAENREQLEILRAKCQ-------- 498
+ +E+ KL Q L E KT QEK +L + +E L+I R + +
Sbjct: 900 DSTLQTVEREKTLITEKL--QQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVN 957
Query: 499 -ELKTHSDGKIAVE---VHKSIVNELKSQLQKE-------EEKERAEMEELMEKLT---- 543
+ T + A+E H+ +N LKS++ +E EE +E +K+
Sbjct: 958 MNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDK 1017
Query: 544 --------------------VLQAQKK--SLLLEKNSLTEQNKALEAELERAQKINRKSQ 581
+++ Q+K SL+ EKN L + +++ AE E+ K + K
Sbjct: 1018 KQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQL-KTDLKEN 1076
Query: 582 KKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVI 641
++ + ++ + +G+E+ Q E + QE++ + +K+G L++
Sbjct: 1077 IEMTIENQEELRLLGDELKKQQ---------EIVAQEKNHAI--------KKEGELSRTC 1119
Query: 642 KSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQ 701
RL ++EEK+K +Q L + +LL QE+ + + + E+ +L LK+K+
Sbjct: 1120 D---RLAEVEEKLKEKSQQ----LQEKQQQLLNVQEEMS-EMQKKINEIENLKNELKNKE 1171
Query: 702 EVLDQALQQNREMEGELEVIWE---STFRENRRIREL 735
L+ + E+ +L +E S +E + ++EL
Sbjct: 1172 LTLEHMETERLELAQKLNENYEEVKSITKERKVLKEL 1208
Score = 76.6 bits (187), Expect = 8e-14
Identities = 107/512 (20%), Positives = 231/512 (45%), Gaps = 73/512 (14%)
Query: 241 EALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPE 300
E L+ +M L +++ + + +L K +E KL+E QE+ A E
Sbjct: 1774 EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQE----KIQELKANE 1829
Query: 301 --LLYLRK---QAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGP 355
L+ L+K + Q+ V E + LK + ++ LS+ + + +L+++ N+E + S
Sbjct: 1830 HQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKS--- 1886
Query: 356 IPPWLLDIKYLSPLLLAYEDMMKEKDELNA---TLKEEMRMFRMRVQEVVKENEELHQEL 412
+MKE+D L TLK E + +QE + E+ QEL
Sbjct: 1887 --------------------VMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQEL 1926
Query: 413 NKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLL 472
K++ + S+E ++ + + + E + + ++ K+KD Q+++QE+ K K+L LL
Sbjct: 1927 -KTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQK--KELQLL 1983
Query: 473 EAK-----THGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKE 527
K +H + E+ + ++Q E Q ++ + ++ ++H+S+ E++
Sbjct: 1984 RVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRM-DNFQLTKKLHESL-EEIRI----- 2036
Query: 528 EEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAE----LERAQKINRKSQKK 583
KER E+ + E L + + Q + L E + QN ++ E + Q + ++K
Sbjct: 2037 VAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREK 2096
Query: 584 IEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKS 643
+K+ +++ +EM H N + L L K +E +K+ L+ +K+
Sbjct: 2097 CSRIKELLKRY--SEMDDHYECLNRLSLD------------LEKEIEFQKE--LSMRVKA 2140
Query: 644 NIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEV 703
N+ L L+ K A + HR++++ + + ++E + K + +
Sbjct: 2141 NLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQH--ESINKFEMDF 2198
Query: 704 LDQALQQNREMEGELEVIWESTFRENRRIREL 735
+D+ +++ +E+ +++ + + +R +R+L
Sbjct: 2199 IDE-VEKQKELLIKIQHLQQDCDVPSRELRDL 2229
Score = 75.9 bits (185), Expect = 1e-13
Identities = 121/572 (21%), Positives = 245/572 (42%), Gaps = 82/572 (14%)
Query: 234 EITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASS 293
E+T E E L+ +L + + E N + EL + + + KLKE K+
Sbjct: 1078 EMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKE--KSQQ 1135
Query: 294 QEVAAPELLYLRKQAQEL---VDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGL 350
+ +LL ++++ E+ ++E + LK + + L +T+ L+++ + N E +
Sbjct: 1136 LQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEV 1195
Query: 351 PSKGPIPPWLLDIKYLSPLLLAYED-------MMKEKDELNATLKEEMRMFRMRVQEVVK 403
S + K L L ++E ++E + KEE+++ + ++E +
Sbjct: 1196 KSITK------ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQE 1249
Query: 404 ENEELHQELNKSSAVT------SEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQE 457
+EL + +++ +A + +LQ + ++ EE +LL E+ + QE
Sbjct: 1250 TIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSET------QE 1303
Query: 458 RLQEVSKLTKQ----------------LMLLEAKTHGQE--KELAENREQL----EILRA 495
+ E+ LT+Q L L E QE K L + R+ L E L
Sbjct: 1304 TMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEV 1363
Query: 496 KCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLE 555
K +LK H +A ++ +S + +S KE++ E ++ ME+ + + +E
Sbjct: 1364 KHDQLKEHIRETLA-KIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIE 1422
Query: 556 KNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENI 615
L+++ + E++ K Q+ EVL+ + ++ N +A+++
Sbjct: 1423 MLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEI---------VAKHL 1473
Query: 616 TQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAAL---KLGDISHRL 672
E + + +A C E++ +N++ + L + E ++ +KQ KL + +
Sbjct: 1474 ETEEE--LKVAHCCLKEQEETINEL---RVNLSEKETEISTIQKQLEAINDKLQNKIQEI 1528
Query: 673 LEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQ---------NREMEGELEV-IW 722
E++E F K QE + + K+ ++ D ALQ NR E + E+ I
Sbjct: 1529 YEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIM 1588
Query: 723 ESTFRENRRIRELLQDTLTRTGVQDNPRALVA 754
E +R++E LQ + R +++N + +VA
Sbjct: 1589 IKEKEEMKRVQEALQ--IERDQLKENTKEIVA 1618
Score = 67.0 bits (162), Expect = 6e-11
Identities = 114/549 (20%), Positives = 253/549 (46%), Gaps = 71/549 (12%)
Query: 236 TREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLK-GMEKEKRKLKEAEKASSQ 294
++E+ + + +E ++ + ++L +E + +K+ KE+ K+K EKE + LK +Q
Sbjct: 1581 SQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQ 1640
Query: 295 EVAAPELLYLRKQ-------AQELVDENDGLKMTVHRLNVELSRYQTKFRH--LSKEESL 345
E E+ +L++Q + + EN L +H N+E R TK R S EE+L
Sbjct: 1641 EKMC-EIEHLKEQFETQKLNLENIETENIRLTQILHE-NLEEMRSVTKERDDLRSVEETL 1698
Query: 346 NIEGLPSKGPIPPWLL-DIKYLSPLLLAYEDMMKEK---DELNATLKEEMRMFRMRVQEV 401
+E K + + D++ L + + + + + D+L + E+ +++
Sbjct: 1699 KVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDL 1758
Query: 402 VKENEEL-------HQELNKSSAVTSEEWRQLQTQAKLVLEE-NKLLLEQLEIQQRKAKD 453
N+ L +EL + E+ + +V E+ +KL Q +++ AK
Sbjct: 1759 EHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAK- 1817
Query: 454 SHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVH 513
QE++QE+ QL+ L+ + +K+++E EQL+ + K Q L K+ +E +
Sbjct: 1818 -LQEKIQELKANEHQLITLKKDVNETQKKVSE-MEQLK-KQIKDQSLTL---SKLEIE-N 1870
Query: 514 KSIVNELKSQLQ--KEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELE 571
++ +L L+ K KER + + E L + + Q K L E + ++ ++ EL+
Sbjct: 1871 LNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKA---RDLEIQQELK 1927
Query: 572 RAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLES 631
A+ ++++ ++ ++ L++++ + + + +++ + +D L + L+
Sbjct: 1928 TARMLSKEHKETVDKLREKIS----------EKTIQISDIQKDLDKSKDELQKKIQELQK 1977
Query: 632 EKDGVL---NKVIKSNIRLGKLEEKVKGYKKQ------AALKLGDISHRLLEQQEDFAGK 682
++ +L V S+ ++ ++E+ K ++ Q + ++ +L E E+
Sbjct: 1978 KELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIR-I 2036
Query: 683 TAQYRQEMRHLHQVLKDKQEVLDQAL-------QQNREMEGELEV-------IWESTFRE 728
A+ R E+R + + LK +++ L +QN +++ E + + ES +
Sbjct: 2037 VAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREK 2096
Query: 729 NRRIRELLQ 737
RI+ELL+
Sbjct: 2097 CSRIKELLK 2105
Score = 63.2 bits (152), Expect = 9e-10
Identities = 100/493 (20%), Positives = 196/493 (39%), Gaps = 52/493 (10%)
Query: 236 TREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKA-SSQ 294
T ++F+ K +MD + + E M Q + L KEA+K SS
Sbjct: 815 TDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLS-------------KEAQKFDSSL 861
Query: 295 EVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKG 354
EL Y ++ QE E + +L +L + + + +E++L E L
Sbjct: 862 GALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQT- 920
Query: 355 PIPPWLLDIKYLSPLLLAYEDMMKEKDELNA---TLKEEMRMFRMRVQEVVKENEELHQE 411
L ++K L+ +EKD+L +L+ E + + + V N + ++
Sbjct: 921 -----LEEVKTLT----------QEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQ 965
Query: 412 LNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKL----TK 467
L + + + T + EE L +E + KD Q+++ + K K
Sbjct: 966 LRNALESLKQHQETINTLKSKISEEVSRNLH-MEENTGETKDEFQQKMVGIDKKQDLEAK 1024
Query: 468 QLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKE 527
L A ++ E+ E + ++ L + EL+ + IA + +LK+ L++
Sbjct: 1025 NTQTLTADV--KDNEIIEQQRKIFSLIQEKNELQQMLESVIAEK------EQLKTDLKEN 1076
Query: 528 EEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVL 587
E EEL L+ Q++ + EKN ++ L +R ++ K ++K + L
Sbjct: 1077 IEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQL 1136
Query: 588 KKQVEKAMG--NEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNI 645
+++ ++ + EMS Q N + EN+ E + + +E+E+ + K + N
Sbjct: 1137 QEKQQQLLNVQEEMSEMQKKINEI---ENLKNELKNKELTLEHMETERLELAQK-LNENY 1192
Query: 646 RLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLD 705
K K + K+ L + Q ++E++ H LK+ QE +D
Sbjct: 1193 EEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETID 1252
Query: 706 QALQQNREMEGEL 718
+ + E ++
Sbjct: 1253 ELRRSVSEKTAQI 1265
Score = 53.1 bits (126), Expect = 1e-06
Identities = 102/495 (20%), Positives = 195/495 (39%), Gaps = 62/495 (12%)
Query: 244 KEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPELLY 303
++E MDL + ++LE T QAM++ QL EK+ + + EK +
Sbjct: 349 RKEIMDLKKQLEEVSLE--TRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSS 406
Query: 304 LRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDI 363
L Q + + + ++N K ++ + + NI P+ L I
Sbjct: 407 LTLQQELKAKRKRRVTWCLGKIN--------KMKNSNYADQFNI---PTNITTKTHKLSI 455
Query: 364 KYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSA------ 417
L + E + E D + TL + + + E + ELN A
Sbjct: 456 NLLREI---DESVCSESDVFSNTL-DTLSEIEWNPATKLLNQENIESELNSLRADYDNLV 511
Query: 418 VTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTH 477
+ E+ R + + +L L+E L E ++++ KD + + E+S L + E
Sbjct: 512 LDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQ 571
Query: 478 GQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEE 537
E EL+ ++E+LR K ++K + I + ++I +L L+ E+ ++ +
Sbjct: 572 DLENELS---SKVELLREKEDQIKKLQE-YIDSQKLENIKMDLSYSLESIEDPKQMKQTL 627
Query: 538 LMEKLTVLQAQKKSLLL--EKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAM 595
+ L A+++S L E L E+ K L ++ + + Q ++E KK
Sbjct: 628 FDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLE 687
Query: 596 GNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRL-GKLEEKV 654
SA + L L DG + K + N+ L GK+ +
Sbjct: 688 KELQSAFNEITKLTSLI---------------------DGKVPKDLLCNLELEGKITDLQ 726
Query: 655 KGYKKQA----ALKLGDISHRLLEQQEDFAGKTAQYRQEMR----HLHQVLKDKQEVLDQ 706
K K+ AL+ I LL + + + + R+E++ LH + +K ++ +
Sbjct: 727 KELNKEVEENEALREEVI---LLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSE 783
Query: 707 ALQQNREMEGELEVI 721
+ + ++G LE I
Sbjct: 784 VVHKESRVQGLLEEI 798
Score = 40.8 bits (94), Expect = 0.005
Identities = 78/385 (20%), Positives = 165/385 (42%), Gaps = 44/385 (11%)
Query: 374 EDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLV 433
E ++K + LK+++ + + E ++L Q L + + + +++ +++
Sbjct: 342 EALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRML 401
Query: 434 LEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLML--------LEAKTHGQEKELAE 485
+ + L L+Q +RK + + L +++K+ + KTH L
Sbjct: 402 VTSSSLTLQQELKAKRKRRVTW--CLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLR 459
Query: 486 NREQLEILRAKCQELKTHSDGKIAV-EVHKSIVNELKSQ--LQKEEEKERAEMEELMEKL 542
EI + C E S+ + E+ + +L +Q ++ E RA+ + L+
Sbjct: 460 -----EIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDY 514
Query: 543 TVLQAQKKSL---LLEKNSLTEQNKALEAELERAQKINRKSQ--KKIEVLKKQVEKAMGN 597
L+ +K+ + L EKN L E EA LER K +++ Q +I LK V+ A
Sbjct: 515 EQLRTEKEEMELKLKEKNDLDE----FEA-LERKTKKDQEMQLIHEISNLKNLVKHAEVY 569
Query: 598 EMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGY 657
L++ V E + ++ D + L + ++S+K + N + + L +E+
Sbjct: 570 NQDLENELSSKV---ELLREKEDQIKKLQEYIDSQK--LENIKMDLSYSLESIED----- 619
Query: 658 KKQAALKLGDISHRLLEQQEDFA---GKTAQYRQEMRHLHQVLKDKQ---EVLDQALQQN 711
KQ L D L+ + + A + + +++M+ L K + ++ L+
Sbjct: 620 PKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAK 679
Query: 712 REMEGELEVIWESTFRENRRIRELL 736
++M+ +LE +S F E ++ L+
Sbjct: 680 KKMQVDLEKELQSAFNEITKLTSLI 704
Score = 33.9 bits (76), Expect = 0.60
Identities = 70/397 (17%), Positives = 152/397 (38%), Gaps = 50/397 (12%)
Query: 234 EITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASS 293
+ + +F ++K E + + + +T L +++ G++KE ++ + +
Sbjct: 2245 DFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFN 2304
Query: 294 QEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSK 353
+ A + ++ E + + + + +L + K L K L S
Sbjct: 2305 NRIIA-----IMNESTEFEERSATISKEWEQ---DLKSLKEKNEKLFKNYQTLKTSLASG 2356
Query: 354 GPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELH---- 409
+ P D K A + ++ EL +L E + +++K +EL
Sbjct: 2357 AQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTND 2416
Query: 410 ---------QELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQ 460
E NK T E + LQ + L + K E++E + K E+++
Sbjct: 2417 IIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYK---EEIEDLKMKLVKIDLEKMK 2473
Query: 461 EVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAK--CQELKTHSD------------G 506
+ K++ +A Q++ + RE L + + H+D G
Sbjct: 2474 NAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGG 2533
Query: 507 KIAVEVHKSIVNELKSQ---LQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQN 563
V+ K+++ LKS+ L+KE K + + E+L+++ L + + L E + E+
Sbjct: 2534 SGIVQNTKALI--LKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERT 2591
Query: 564 KALEAELE-------RAQKINRKSQKKIEVLKKQVEK 593
EA + ++ K+ + KK ++ Q ++
Sbjct: 2592 LKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKE 2628
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 88.6 bits (218), Expect = 2e-17
Identities = 139/690 (20%), Positives = 289/690 (41%), Gaps = 94/690 (13%)
Query: 125 DEEDIETQLSSSGKELGDVSAREDRGGHSDDLYAVPHRNQVPLLHEVNSEDDENISHQDG 184
D++ IE +L EL + A+ D + ++++ + ++ L E +E I +
Sbjct: 1076 DKQQIEEKLKKKEFELSQLQAKID----DEQVHSLQFQKKIKELQARIEELEEEIEAEHT 1131
Query: 185 FPGSPPAPQRTQQKDGKHPVLNLKDEKPPLCEKPPPSPDITGRARQRYTEITREKFEALK 244
A Q+ D + + + ++ + + ++ R+ EA
Sbjct: 1132 LR----AKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATL 1187
Query: 245 EENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEA--EKASSQEVAAPELL 302
+ + + + + + + LQ + +EKEK +LK + AS+ E +
Sbjct: 1188 QHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKS 1247
Query: 303 YLRKQAQELVDENDGLK-------MTVHRLNVELSRYQTKFRHLS----KEESLNIEGLP 351
+ + + + D+ +K +H LN++ +R QT+ LS ++ESL +
Sbjct: 1248 NIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTK 1307
Query: 352 SKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATL---KEEMRMFRMRVQEVVKENEEL 408
SK + L ++K E+ K K+ + L + + + R + +E + EL
Sbjct: 1308 SKQALTQQLEELKR------QMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAEL 1361
Query: 409 HQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQ 468
+ L+K+++ ++ + +T A EE LE ++K QE + +
Sbjct: 1362 QRALSKANSEVAQWRTKYETDAIQRTEE-------LEEAKKKLAQRLQEAEENTETANSK 1414
Query: 469 LMLLEAKTHGQEKELAENREQLEILRAKCQEL--KTHSDGKIAVEVHKSIVNELKSQLQK 526
LE + E+ + LE C L K + K+ E K ++E +++L+
Sbjct: 1415 CASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAE-WKQKLDESQAELEA 1473
Query: 527 EEEKERA----------EMEELMEKLTVLQAQKKSLLLEKNSLTEQ----NKALEAELER 572
+++ R+ EE++++L L+ + K+L E + LTEQ K L+ E E+
Sbjct: 1474 AQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQ-EAEK 1532
Query: 573 AQKINRKSQKKIEVLKKQVEKAMGNEMS------------AHQYLANLVGLAENITQERD 620
+K+ + + ++V ++VE ++ +E S + ++ E I Q +
Sbjct: 1533 TKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKR 1592
Query: 621 SLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFA 680
+ A+ L+S VL+ I+S +L++K++G + ++LG + ++ E Q
Sbjct: 1593 NSQRAAEALQS----VLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQ---- 1644
Query: 681 GKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDTL 740
+ +R + LKD Q LD AL+ N +++ +L ++ R N + E L++
Sbjct: 1645 -------KHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIV----ERRNGLLLEELEEMK 1693
Query: 741 TRTGVQDNPRALVAPSLNGVSQADLLDGCD 770
+ R L S+ +LLD D
Sbjct: 1694 VALEQTERTRRL--------SEQELLDASD 1715
Score = 75.9 bits (185), Expect = 1e-13
Identities = 124/560 (22%), Positives = 237/560 (42%), Gaps = 93/560 (16%)
Query: 243 LKEENMDLNNM---NQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAP 299
L+ +N +L++ +SL +L KQA+ + +LK +E+ K K A A + + +
Sbjct: 1284 LQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNA-MAHALQSSRH 1342
Query: 300 ELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRH--LSKEESL------------ 345
+ LR+Q +E + L+ + + N E+++++TK+ + + E L
Sbjct: 1343 DCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1402
Query: 346 ----NIEGLPSK------------GPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKE 389
N E SK G + + D++ + + D++ A K+
Sbjct: 1403 EAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQ 1462
Query: 390 EMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQT---QAKLVLEENKLLLEQLEI 446
++ + ++ KE+ L EL K E QL+T + K + EE L EQ+
Sbjct: 1463 KLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAE 1522
Query: 447 QQRKAKDSHQ-ERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQ------- 498
+ +++ + ++L E K Q+ L E + + +E R QLE+ + K +
Sbjct: 1523 TGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIE 1582
Query: 499 ------ELKTHSDGKIAVEVHKSIVN-ELKSQ-----LQKEEEKERAEME---------- 536
+LK +S A E +S+++ E++S+ L+K+ E + EME
Sbjct: 1583 KDEEIEQLKRNSQR--AAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQM 1640
Query: 537 -ELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAM 595
E + L +Q Q K L + N+ L+ +L ++ N +++E +K +E+
Sbjct: 1641 AETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTE 1700
Query: 596 GNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVK 655
+ Q L + + + + SL+ K LE++ +V S EEK K
Sbjct: 1701 RTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAK 1760
Query: 656 GYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQ------ 709
AA+ + L++++D +A + ++L Q +KD Q LD+A Q
Sbjct: 1761 KAITDAAMMAEE-----LKKEQD---TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGG 1812
Query: 710 ---------QNREMEGELEV 720
+ RE+E EL+V
Sbjct: 1813 KKQIQKLENRVRELENELDV 1832
Score = 67.0 bits (162), Expect = 6e-11
Identities = 101/520 (19%), Positives = 217/520 (41%), Gaps = 53/520 (10%)
Query: 238 EKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVA 297
E+ E +E N +L ++L + +++K+ + +L+L L +EKEK + K S+E+
Sbjct: 928 ERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMT 987
Query: 298 APELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIP 357
A E + K +E + + T+ L VE + + +K E +
Sbjct: 988 ALE-ENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDD--------- 1037
Query: 358 PWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSA 417
L L + + + + L+ +++M + + ++ + +++ ++L K
Sbjct: 1038 --------LEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKK--- 1086
Query: 418 VTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTH 477
+E+ Q QAK+ E+ L Q +I++ +A R++E+ + + L AK
Sbjct: 1087 ---KEFELSQLQAKIDDEQVHSLQFQKKIKELQA------RIEELEEEIEAEHTLRAKIE 1137
Query: 478 GQEKELAENREQLEILRAKCQELKTHSDGKIAV------EVHKSIVNELKSQLQKE---- 527
Q +LA +LE + + +E + +I + E K + ++ LQ E
Sbjct: 1138 KQRSDLA---RELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1194
Query: 528 --EEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIE 585
+K+ + EL E++ LQ K+ L EK+ L + + + +E K ++
Sbjct: 1195 TLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCR 1254
Query: 586 VLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNI 645
++ Q + + Q + +L + + L + EK+ +++++ KS
Sbjct: 1255 TVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVE----EKESLISQLTKSKQ 1310
Query: 646 RLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMR---HLHQVL-KDKQ 701
L + E++K ++ ++H L + D QY +E L + L K
Sbjct: 1311 ALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANS 1370
Query: 702 EVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDTLT 741
EV + + E + E+ + +R++E ++T T
Sbjct: 1371 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTET 1410
Score = 65.9 bits (159), Expect = 1e-10
Identities = 100/517 (19%), Positives = 218/517 (42%), Gaps = 83/517 (16%)
Query: 237 REKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKG-----MEKEKR-------- 283
+E FE KEE + L ++ ++ Q +LQL+++ M+ E+R
Sbjct: 857 KEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSK 916
Query: 284 -----KLKE-AEKASSQEVAAPELLYLRKQAQE----LVDENDGLKMTVHRLNVELSRYQ 333
K+KE E+ +E EL+ ++ ++ L + D L++T+ ++ E +
Sbjct: 917 ILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATE 976
Query: 334 TKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEK---DELNATLKEE 390
K ++LS+E + E + + KEK E + ++
Sbjct: 977 NKVKNLSEEMTALEENI-----------------------SKLTKEKKSLQEAHQQTLDD 1013
Query: 391 MRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLE-QLEIQQR 449
+++ +V ++K N +L Q+ + +E + + LE K LE L++ Q
Sbjct: 1014 LQVEEDKVNGLIKINAKLEQQTDDLEGSLEQE-----KKLRADLERAKRKLEGDLKMSQE 1068
Query: 450 KAKDSHQERLQEVSKLTK---QLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDG 506
D ++ Q KL K +L L+AK ++ + +++++ L+A+ +EL+ +
Sbjct: 1069 SIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEA 1128
Query: 507 KIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKAL 566
+ + L+++++K+ E+EE+ E+L + + E NK
Sbjct: 1129 E----------HTLRAKIEKQRSDLARELEEISERLEEASGATSAQI-------EMNKKR 1171
Query: 567 EAELERAQKINRKSQKKIEVLKKQVEKAMGNEMS-AHQYLANLVGLAENITQERDSLMCL 625
EAE ++ ++ ++ + E + K + ++ + + NL + + + +E+ L
Sbjct: 1172 EAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKME 1231
Query: 626 AKCLESEKDGVLNKVIKSNI-RLGKLEE----KVKGYKKQAALKLGDISHRLLEQQEDFA 680
+ S + + KSNI R + E ++K +Q + D++ + Q
Sbjct: 1232 IDDMASNIEALSKS--KSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNG 1289
Query: 681 GKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGE 717
+ + ++ + Q+ K KQ + Q + R+ME E
Sbjct: 1290 ELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEE 1326
Score = 54.7 bits (130), Expect = 3e-07
Identities = 92/453 (20%), Positives = 194/453 (42%), Gaps = 55/453 (12%)
Query: 230 QRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKE----KRKL 285
Q E +++ +L E + N + + +L T+++ K LQ ++ + ++ + L
Sbjct: 1468 QAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNL 1527
Query: 286 KEAEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESL 345
+EAEK ++++ E L+ +E+ + + + R+ +ELS+ +++ E+
Sbjct: 1528 QEAEK--TKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDE 1585
Query: 346 NIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKEN 405
IE L L L + + D ++ K ++ L E M +Q + +
Sbjct: 1586 EIEQLKRNSQRAAEALQ-SVLDAEIRSRNDALRLKKKMEGDLNE------MEIQ--LGHS 1636
Query: 406 EELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKL 465
E K + + Q L N+ L EQL I +R+ + L+E+ ++
Sbjct: 1637 NRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERR----NGLLLEELEEM 1692
Query: 466 TKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQ 525
L E E+EL + +++++L ++ + S++N K +L+
Sbjct: 1693 KVALEQTERTRRLSEQELLDASDRVQLLHSQ----------------NTSLINT-KKKLE 1735
Query: 526 KEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKA---LEAELERAQKINRKSQK 582
+ + +AE+E +++ + + K + + + E+ K A LER +K ++ K
Sbjct: 1736 ADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 1795
Query: 583 KIEVLKKQVEK-AMGNEMSAHQYLANLVGLAEN---ITQER--DSLMCLAK--------C 628
++ + E+ A+ Q L N V EN + Q+R ++L K
Sbjct: 1796 DLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMT 1855
Query: 629 LESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQA 661
++E+D +++ + KL+ KVK YK+QA
Sbjct: 1856 YQAEEDH--KNILRLQDLVDKLQAKVKSYKRQA 1886
Score = 43.1 bits (100), Expect = 0.001
Identities = 59/242 (24%), Positives = 110/242 (45%), Gaps = 35/242 (14%)
Query: 527 EEEKERAEMEE----LMEKLTVLQAQKK-------SLLLEKNSL-----TEQNKALEAEL 570
E EKE A M+E E+L +A++K SLL EKN L +E ++AE
Sbjct: 848 EAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAE- 906
Query: 571 ERAQKINRKS---QKKIEVLKKQV--EKAMGNEMSAHQYLANLVGLAENITQERDSLMCL 625
ER + + + + K++ L +++ E+ M +E+ A + NL ++ ++ D L
Sbjct: 907 ERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKK--RNLEDKCSSLKRDIDDLELT 964
Query: 626 AKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGK--- 682
+E EK NKV + + LEE + K+ L + + L+ + K
Sbjct: 965 LTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKK-SLQEAHQQTLDDLQVEEDKVNG 1023
Query: 683 ----TAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTF---RENRRIREL 735
A+ Q+ L L+ ++++ + R++EG+L++ ES + ++I E
Sbjct: 1024 LIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEK 1083
Query: 736 LQ 737
L+
Sbjct: 1084 LK 1085
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 88.6 bits (218), Expect = 2e-17
Identities = 121/556 (21%), Positives = 235/556 (42%), Gaps = 63/556 (11%)
Query: 198 KDGKHPVLNLKDEKPPLCEKPPPSPDITGRARQRYTEIT---REKFEALKEENMDLNNMN 254
K + +L L++E L + P+ D + +E+ E +K E L+
Sbjct: 1683 KSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKF 1742
Query: 255 QSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPELLYLRKQAQELVDE 314
QSL E +++ + +++L+ +++G ++ L+ EK +Q E + +E
Sbjct: 1743 QSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGT---QSIPGETEE 1799
Query: 315 NDGLKMTVHRLNVE-LSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAY 373
D L M+ E + ++ +SK+ S + E I +L I L +
Sbjct: 1800 QDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDE-------INNYLQQIDQLKERIAGL 1852
Query: 374 EDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKL- 432
E+ ++ E + TL+ E ++ E + L +E+ K + + + +L KL
Sbjct: 1853 EEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLK 1912
Query: 433 --VLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQL 490
EE L E+L Q + S Q+V+ + LLE++ +K ++E E+
Sbjct: 1913 ETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEE- 1971
Query: 491 EILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKK 550
K Q +K + K+ E+ K + +++ ++ K A+ EL E L Q + K
Sbjct: 1972 -----KQQLVKEKT--KVESEIRKEYLEKIQGAQKEPGNKSHAK--ELQELLKEKQQEVK 2022
Query: 551 SLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVG 610
L + E+ ALE ++ + + +SQK +E+ K+ + +A+ + A LA+
Sbjct: 2023 QLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASF-- 2080
Query: 611 LAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGK-LEEKVKGYKKQAALKLGDIS 669
K L + +V+ N++L K L+ + K Q K D+
Sbjct: 2081 ----------------KVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLE 2124
Query: 670 HRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREME---GELEVIWESTF 726
RL + +E +HL + K+ QE LD ++ +E GE++V
Sbjct: 2125 RRLEQAEE-------------KHLKE-KKNMQEKLDALRREKVHLEETIGEIQVTLNKKD 2170
Query: 727 RENRRIRELLQDTLTR 742
+E ++++E L T+T+
Sbjct: 2171 KEVQQLQENLDSTVTQ 2186
Score = 72.0 bits (175), Expect = 2e-12
Identities = 111/535 (20%), Positives = 229/535 (42%), Gaps = 45/535 (8%)
Query: 221 SPDITGRARQRYTEITREKFEALKEENMDLNN-MNQSLTLELNTMKQAMKE---LQLKLK 276
SP TG + E+ EK AL++E L + ++LT +K+A ++ L+ +LK
Sbjct: 1148 SPPCTGSSEHWKPEL-EEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELK 1206
Query: 277 GMEKEKRKLKEA--EKASSQEVAAPELLYLRKQAQELVD----ENDGLKMTVHRLNVELS 330
+ + +L+E E++ E +L L+ Q +E +D D + +E
Sbjct: 1207 QQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEP 1266
Query: 331 RYQTKFRHLSKE--ESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLK 388
++ +H ++ ES PS L ++ + +++ EK EL +
Sbjct: 1267 LFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVS 1326
Query: 389 EEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLE--ENKLLLEQLEI 446
+ +EV +L +++NK + E + + +A++ E + KL QL+I
Sbjct: 1327 STTSELTKKSEEVF----QLQEQINKQG-LEIESLKTVSHEAEVHAESLQQKLESSQLQI 1381
Query: 447 QQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQ--EKELAENREQLEILRAKCQELKTHS 504
+ Q +L E+ KL + + GQ EKE A + Q EI+ + H+
Sbjct: 1382 AGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHT 1441
Query: 505 DGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNK 564
++ + H + +L+ +L + ++K EE K + + + +L+ K +L E NK
Sbjct: 1442 QLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKE-NK 1500
Query: 565 ALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMC 624
+L+ EL A+ + K + ++ QV A+N +E+D+++
Sbjct: 1501 SLQEELSLARGTIERLTKSLADVESQVS-------------------AQN--KEKDTVLG 1539
Query: 625 LAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTA 684
L+ E+D ++ ++ +S + L + K A L + +L+++ E
Sbjct: 1540 RLALLQEERDKLITEMDRSLLENQSLSSSCESL-KLALEGLTEDKEKLVKEIESLKSSKI 1598
Query: 685 QYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDT 739
E + H+ L+ + E+L Q+ + ++ + E+ +E + + L+ T
Sbjct: 1599 AESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRST 1653
Score = 71.6 bits (174), Expect = 3e-12
Identities = 97/519 (18%), Positives = 216/519 (41%), Gaps = 70/519 (13%)
Query: 242 ALKEENMD--LNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKL-KEAEKASSQEVAA 298
AL +E D + M++SL LE ++ + + L+L L+G+ ++K KL KE E S ++A
Sbjct: 1542 ALLQEERDKLITEMDRSL-LENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIA- 1599
Query: 299 PELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPP 358
E + +Q K + L KE + ++ +
Sbjct: 1600 -----------------------------ESTEWQEKHKELQKEYEILLQSYENVSNEAE 1630
Query: 359 WLLDIKYLSPLLLAYEDMMKEKDELNATLKE---EMRMFRMRVQEVVKENEELHQELNKS 415
+ + E + +EK EL L+ + ++QE +E EE+ +++ K
Sbjct: 1631 RIQHV---------VEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKF 1681
Query: 416 SAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAK 475
+ ++ +L+ EEN L ++ AK+ + L + + ++L ++ +
Sbjct: 1682 AKSKQQKILELE-------EENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKME 1734
Query: 476 THGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEM 535
K+ + + L + Q+LK +G ++ + + + +Q EE ++
Sbjct: 1735 YETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIP 1794
Query: 536 EELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAM 595
E E+ ++ + + + S N A+ + +IN Q +I+ LK+++
Sbjct: 1795 GETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQ-QIDQLKERIAGLE 1853
Query: 596 GNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEE--- 652
+ ++ ++ + E+++L+ + E + +V K N+ +++E
Sbjct: 1854 EEKQKNKEF-------SQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELS 1906
Query: 653 KVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNR 712
+V K+ A + D+ RL+ Q + G Y Q++ + K E+L+ ++ +
Sbjct: 1907 RVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTD----AQIKNELLESEMKNLK 1962
Query: 713 EMEGELEVIWESTFRENRRIR-ELLQDTLTR-TGVQDNP 749
+ ELE + +E ++ E+ ++ L + G Q P
Sbjct: 1963 KCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEP 2001
Score = 70.9 bits (172), Expect = 4e-12
Identities = 106/519 (20%), Positives = 220/519 (42%), Gaps = 64/519 (12%)
Query: 254 NQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPELL-YLRKQAQELV 312
N L EL + K+++K Q+K K + E+R + EK ++ E L LR++ L
Sbjct: 2098 NLKLKKELQSNKESVKS-QMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLE 2156
Query: 313 DENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDI-----KYLS 367
+ +++T+++ + E+ + Q + + + + S ++D + S
Sbjct: 2157 ETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFS 2216
Query: 368 PLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQ 427
+ + E+ ++ K++ + LK+++R + ++E+ L + + E + Q
Sbjct: 2217 DAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQ 2276
Query: 428 TQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENR 487
+ ENK LL QLE + R S Q L AK + K L +
Sbjct: 2277 KVCDTLQGENKELLSQLE-ETRHLYHSSQNEL--------------AKLESELKSLKDQL 2321
Query: 488 EQLEILRAKCQELKTHSDGKIA-----VEVHKSIVNELKSQLQKEEEKERAEMEELMEK- 541
L KC+E K + +G I ++ K +L++ LQ E EE+ K
Sbjct: 2322 TDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKE 2381
Query: 542 ---LTVLQAQKKSLLLEKNSLTEQNKALEAELER-----------AQKINRKSQKKIEVL 587
+++L +++++ + L +Q+ ELE ++ N+K+ K L
Sbjct: 2382 QKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQL 2441
Query: 588 KKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLES-------EKDGVLNKV 640
+ ++ + L + V ++ +RD ++ + LE EKD ++ +
Sbjct: 2442 METLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEA 2501
Query: 641 IKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDK 700
N KL+E+++G + + D++ + + QYR+++ + +KD
Sbjct: 2502 AAEN---NKLKEEIRGLRSH----MDDLN----SENAKLDAELIQYREDLNQV-ITIKDS 2549
Query: 701 Q--EVLDQALQQNREMEGELEVIWESTFRENRRIRELLQ 737
Q ++L+ LQQN+E+E + + E +E+ E L+
Sbjct: 2550 QQKQLLEVQLQQNKELENKYAKL-EEKLKESEEANEDLR 2587
Score = 69.7 bits (169), Expect = 1e-11
Identities = 107/482 (22%), Positives = 212/482 (43%), Gaps = 43/482 (8%)
Query: 260 ELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQE--VAAPELLYLRKQAQELVDENDG 317
E+N Q + +L+ ++ G+E+EK+K KE + E ++ + + L +E
Sbjct: 1834 EINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTK 1893
Query: 318 LKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMM 377
+ + ++ ELSR TK + ++EE ++E + + L+ + Y +
Sbjct: 1894 MNLLNQQIQEELSRV-TKLKETAEEEKDDLE--------ERLMNQLAELNGSIGNYCQDV 1944
Query: 378 KEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNK-SSAVTSEEWRQLQTQAKLVLEE 436
+ N L+ EM+ + V E+ +E ++L +E K S + E ++Q K +
Sbjct: 1945 TDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNK 2004
Query: 437 N--KLLLEQLEIQQRKAKD------SHQERLQEVSKLTKQLMLLEAKTHGQEKELAENRE 488
+ K L E L+ +Q++ K +QE++ + + K L ++ ++ + EN
Sbjct: 2005 SHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLA 2064
Query: 489 QLEILRAKCQ----ELKTHSDGKIAVEVHKSIVN-ELKSQLQKEEEKERAEMEELMEKLT 543
Q R K Q K D + N +LK +LQ +E +++M++ E L
Sbjct: 2065 QAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLE 2124
Query: 544 --VLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSA 601
+ QA++K L EK ++ E+ AL E ++ + Q + K+V++ N S
Sbjct: 2125 RRLEQAEEKHLK-EKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDST 2183
Query: 602 HQYLANLVGLAENITQERDSLMCLAKCLESE-KDGVLNKVIKSNIRLGKLEEKV-KGYKK 659
LA ++ +RD ++ AK E + D + +K + IRL + V K +
Sbjct: 2184 VTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSK--EEEIRLKEDNCSVLKDQLR 2241
Query: 660 QAALKLGDISHRL--LEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGE 717
Q ++ + ++ + LE + AQ ++ +Q+V D +N+E+ +
Sbjct: 2242 QMSIHMEELKINISRLEHDKQIWESKAQTEVQL---------QQKVCDTLQGENKELLSQ 2292
Query: 718 LE 719
LE
Sbjct: 2293 LE 2294
Score = 65.5 bits (158), Expect = 2e-10
Identities = 92/489 (18%), Positives = 211/489 (43%), Gaps = 30/489 (6%)
Query: 240 FEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAP 299
F AL EE L + + L++ + ++ +K+L++ L E+++R E++ A +
Sbjct: 739 FTALSEERDQLLSQVKELSM-VTELRAQVKQLEMNLAEAERQRRLDYESQTAHDN-LLTE 796
Query: 300 ELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKE----ESLNIEGLPSKGP 355
++ L +A+ + + L+ + + ++ S T R L + ES +EG
Sbjct: 797 QIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRH 856
Query: 356 IPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKS 415
I ++ LS L E + + D+L K ++ + ++E ++ E+ + +
Sbjct: 857 ISS---KVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEK 913
Query: 416 SAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAK 475
+EE L + K + E+ LL + +AK E EVS KQ E
Sbjct: 914 MVQLNEEKFSLGVEIKTLKEQLNLL-----SRAEEAKKEQVEEDNEVSSGLKQ-NYDEMS 967
Query: 476 THGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVN--ELKSQLQKEEEKERA 533
GQ + E + + ++L+ + ++ K ++ +++N EL ++ + EE+
Sbjct: 968 PAGQISK-EELQHEFDLLKKENEQRKR--------KLQAALINRKELLQRVSRLEEELAN 1018
Query: 534 EMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEK 593
+E +++ + + ++ + +K + K + ++ + + +++ + EV + + K
Sbjct: 1019 LKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRK 1078
Query: 594 AMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEK 653
+ +++A + LV Q++ + + L + SE ++ K+I SN +
Sbjct: 1079 DLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASD-GDS 1137
Query: 654 VKGYKKQAALK---LGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQ 710
V K+ + G H E +E + Q + L + L ++ +L +A ++
Sbjct: 1138 VALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEK 1197
Query: 711 NREMEGELE 719
R + EL+
Sbjct: 1198 ERHLREELK 1206
Score = 64.7 bits (156), Expect = 3e-10
Identities = 114/572 (19%), Positives = 245/572 (42%), Gaps = 67/572 (11%)
Query: 223 DITGRARQRYTEITREKF--EALKEENMDLNNMNQSLTLELNTMKQAM--------KELQ 272
++ G RQ+ +I KF E L+ + + L E+N +Q + + +Q
Sbjct: 2337 NLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQ 2396
Query: 273 LKLKGMEKEKRK-LKEAEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSR 331
+ + + ++ K +KE E SQE E + L ++ ++ VD+ + L T+ + E +
Sbjct: 2397 VAIAELRQQHDKEIKELENLLSQE--EEENIVLEEENKKAVDKTNQLMETLKTIKKENIQ 2454
Query: 332 YQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEM 391
+ + K S +++ + L+ ++LS ++L + +++E N LKEE+
Sbjct: 2455 QKAQLDSFVKSMS-SLQNDRDRIVGDYQQLEERHLS-IILEKDQLIQEAAAENNKLKEEI 2512
Query: 392 RMFRMRVQEVVKENEELHQEL-----NKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEI 446
R R + ++ EN +L EL + + +T ++ +Q Q ++ L++NK L +
Sbjct: 2513 RGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQL-LEVQLQQNKELENKYAK 2571
Query: 447 QQRKAKDSH-------------QERLQEVSKLTKQLMLLEAKTHGQEKELAENRE-QLEI 492
+ K K+S QE Q++SK + L + ++ Q L E L
Sbjct: 2572 LEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYH 2631
Query: 493 LRAKCQELKTHSDGKIAVEVHKSIVNELKSQL---QKEEEKERAEMEELMEKLTVLQAQK 549
+ K +E + H + K I EL+ +L QKE K+ E+E+ ++K +
Sbjct: 2632 AQLKVKEEEVHRLSALFSSSQKRIA-ELEEELVCVQKEAAKKVGEIEDKLKK------EL 2684
Query: 550 KSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLV 609
K L + + + + E + + + ++K+ ++ K+ + S + +++L
Sbjct: 2685 KHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQ 2744
Query: 610 GLAENITQERDSL-----MCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALK 664
++ +E D L L + + ++ G+LN+ + + L + + ++ +
Sbjct: 2745 NSRDHANEELDELKRKYDASLKELAQLKEQGLLNR--ERDALLSETAFSMNSTEENSLSH 2802
Query: 665 LGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWE- 723
L ++ +LL + E ++ HL L+D + + ++ E + +W
Sbjct: 2803 LEKLNQQLLSKDE-----------QLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNE 2851
Query: 724 -STFR--ENRRIRELLQDTLTRTGVQDNPRAL 752
FR E + R Q + + VQ +A+
Sbjct: 2852 LEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAM 2883
Score = 52.8 bits (125), Expect = 1e-06
Identities = 124/638 (19%), Positives = 255/638 (39%), Gaps = 125/638 (19%)
Query: 167 LLHEVNSEDDENISHQDGFPGSPPAPQRTQQKDGKHPVLNLKDEKPPLCEKPPPSPDITG 226
+LHE++ +DD + + + +P P+ Q+ D + +D + L ++
Sbjct: 12 VLHELSGDDDTDQNMR-----APLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKD 66
Query: 227 RARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKEL--QLKLKG------- 277
RQ+ ++ ++K EAL+EE +N + L L ++ + ++K +G
Sbjct: 67 IIRQKDVQL-QQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTE 125
Query: 278 --------------------MEKEKRKLKE----------------AEKASSQEVAAPEL 301
+EK K KL+E AE+ + E
Sbjct: 126 PQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEF 185
Query: 302 LYLRKQAQELVDENDGLKMTVHRLNVELS----------RYQTKFRHLSKEESLNIEGLP 351
+ +++Q QE + L+ + + E + R++T+ R L ++E L L
Sbjct: 186 VMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVR-LHEDELLQ---LV 241
Query: 352 SKGPIPPWLLD-IKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQ 410
++ + + ++ L L +E+ + + ++ L++E+ R N+ L Q
Sbjct: 242 TQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQR-------NQILSQ 294
Query: 411 ELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLM 470
+L + A E L+ + EE+K+LLE++E++ + K S +E+ L +Q
Sbjct: 295 QLQQMEA----EHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQF- 349
Query: 471 LLEAKTHGQ-EKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEE 529
+ GQ + EL LE + HK+ + E S + ++
Sbjct: 350 ----EQAGQAQAELESRYSALE-------------------QKHKAEMEEKTSHILSLQK 386
Query: 530 KERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQN----KALEAELERAQK-----INRKS 580
+EL L+ Q LL +KN Q+ + LE +L++ K +NR
Sbjct: 387 TG----QELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLP 442
Query: 581 QKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQ-ERDSLMCLAKCLESEKDGVLNK 639
++ E + + NE + N+ L + + + E + L +E E+ N+
Sbjct: 443 LQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENE 502
Query: 640 VIKSNIRLGKLEEKV-KGYKKQAALKLGDISHRLLEQQED-----FAGKTAQYRQEMRHL 693
+ S I L + + + + ++ + + + DI+++ E+ +Q +E+ L
Sbjct: 503 KLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVL 562
Query: 694 HQVLKDKQE---VLDQALQQNREMEGELEVIWESTFRE 728
+K+ QE L LQ R E + EV+ + ++
Sbjct: 563 LLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQ 600
Score = 45.8 bits (107), Expect = 2e-04
Identities = 67/332 (20%), Positives = 141/332 (42%), Gaps = 43/332 (12%)
Query: 407 ELHQELNKS-SAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKL 465
ELHQE + + T E+ ++ A+ ++ E K ++ Q ++Q ++ ++ QE +
Sbjct: 33 ELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNK 92
Query: 466 TKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQ 525
K+L K H + K + N+ E+ L T + + H E + +++
Sbjct: 93 IKKL-----KLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIE 147
Query: 526 KEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIE 585
K + K ++E E ++ LQAQ + EQ E+E + ++ Q+K E
Sbjct: 148 KIKHK----LQEKEELISTLQAQLTQ------AQAEQPAQSSTEMEEFVMMKQQLQEKEE 197
Query: 586 VLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNI 645
+ +A ++ A Q A+ + +E+D+ + +D +L V ++++
Sbjct: 198 FISTL--QAQLSQTQAEQ-------AAQQVVREKDARF--ETQVRLHEDELLQLVTQADV 246
Query: 646 RLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLD 705
++++K++ + R LE+ E+ AQ ++ + + ++L
Sbjct: 247 ET-EMQQKLR------------VLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILS 293
Query: 706 QALQQNREMEGELEVIWESTFRENRRIRELLQ 737
Q LQQ ME E + + E + LL+
Sbjct: 294 QQLQQ---MEAEHNTLRNTVETEREESKILLE 322
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 88.2 bits (217), Expect = 3e-17
Identities = 111/536 (20%), Positives = 240/536 (44%), Gaps = 62/536 (11%)
Query: 221 SPDITGRARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEK 280
SP+ +A ++ E R + EA L L + L + A+K+L+ + + +
Sbjct: 167 SPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLIS 226
Query: 281 EKRKLKEAEK-ASSQEVAAPELLYLRKQA----QELVDENDGLKMTVHR-------LNVE 328
+L ++ K A E A + +K+A +EL E D L + ++R L +
Sbjct: 227 ---RLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEK 283
Query: 329 LSRYQTKFRHLSKEES---LNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNA 385
++ Q K + + E+S LN++ L K + LLL + + E D L
Sbjct: 284 NAKLQEKLQLVESEKSEIQLNVKELKRK----------LERAKLLLPQQQLQAEADHLG- 332
Query: 386 TLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQT----QAKLVLEENKLLL 441
+E++ ++Q V+ENE L LN+ + WRQ + + K+ +E K+
Sbjct: 333 ---KELQSVSAKLQAQVEENE-LWNRLNQQQE--EKMWRQEEKIQEWEEKIQEQEEKIRE 386
Query: 442 EQLEIQQRKAKDSHQERL--QEVSKLTKQLMLL---EAKTHGQEKELAENREQLEILRAK 496
++ +I++++ K QE + ++ K+ +Q ++ E K QE+ + E E++ L
Sbjct: 387 QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIREL--- 443
Query: 497 CQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERA---EMEELMEKLTVLQAQKKSLL 553
E K H KI + K E + +K +E+E + E++ E+ ++ Q++ +
Sbjct: 444 --EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMW 501
Query: 554 LEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAE 613
++ + EQ K E E + Q+ + ++KI ++ E+ + H+ + E
Sbjct: 502 RQEEKIHEQEKIREEEKRQEQEEMWRQEEKI----REQEEIWRQKEKIHEQEEKIRKQEE 557
Query: 614 NITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAAL------KLGD 667
+ ++ + + + + +++ V + K + K+ E+ + ++Q + K+G+
Sbjct: 558 KMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGE 617
Query: 668 ISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWE 723
++ EQ+E + + R++ + + K +E ++ +Q M+ + E +WE
Sbjct: 618 QEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE 673
Score = 68.2 bits (165), Expect = 3e-11
Identities = 79/407 (19%), Positives = 183/407 (44%), Gaps = 50/407 (12%)
Query: 239 KFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAA 298
K +A EEN N +NQ ++ ++ ++E + K++ E+E++ ++ EK QE
Sbjct: 341 KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQ--EQEEKIREQEEKIREQEEK- 397
Query: 299 PELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPP 358
+R+Q +E++ E + + E + + E+ I L K
Sbjct: 398 -----MRRQ-EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK----- 446
Query: 359 WLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRM-RVQEVVKENEELHQE------ 411
+ + E+ +E++++ K + + +M R +E ++E EE +E
Sbjct: 447 -----MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMW 501
Query: 412 -----LNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLT 466
+++ + EE RQ Q + + + + + EQ EI ++K K QE +++ K
Sbjct: 502 RQEEKIHEQEKIREEEKRQEQEE---MWRQEEKIREQEEIWRQKEKIHEQE--EKIRKQE 556
Query: 467 KQLMLLEAKTHGQEKELAEN-----------REQLEILRAKCQELKTHSDGKIAVEVHKS 515
+++ E K H QE+++ E REQ E +R + ++++ + + +
Sbjct: 557 EKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEE---MTQEQEE 613
Query: 516 IVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQK 575
+ E + ++ ++EEK + + E++ + ++ Q+K + ++ + EQ + ++ + E+ +
Sbjct: 614 KMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE 673
Query: 576 INRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSL 622
K ++ E +++Q EK E + L E + + ++ L
Sbjct: 674 QEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 720
Score = 60.1 bits (144), Expect = 8e-09
Identities = 80/459 (17%), Positives = 203/459 (44%), Gaps = 69/459 (15%)
Query: 126 EEDIETQLSSSGKELGDVSAREDRGGHSDDLYAVPHRNQVPLLHEVNSEDDENISHQDGF 185
++ ++ + GKEL VSA+ L A N+ L + +N + +E + Q+
Sbjct: 321 QQQLQAEADHLGKELQSVSAK---------LQAQVEENE--LWNRLNQQQEEKMWRQE-- 367
Query: 186 PGSPPAPQRTQQKDGKHPVLNLKDEKPPLCEKPPPSPDITGRARQRYTEITREKFEALKE 245
++ Q+ + K +++++ + E+ + + R R E+ EK E ++
Sbjct: 368 -------EKIQEWEEK-----IQEQEEKIREQEEKIREQEEKMR-RQEEMMWEKEEKMRR 414
Query: 246 ENMDLNNMNQSLTLELNTM---KQAMKELQLKLKGMEK---EKRKLKEAEKASSQEVAAP 299
+ + + + + M ++ ++EL+ K+ EK ++ K +E EK QE
Sbjct: 415 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 474
Query: 300 ELLYLRKQAQELVDENDGLKMTVHRL--NVELSRYQTKFRHLSKEESLNIEGLPSKGPIP 357
+ + +Q +++ ++ + ++ ++ E Q K R K +
Sbjct: 475 QEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQE----------E 524
Query: 358 PWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSA 417
W + K + E++ ++K++++ E+ R + +++ ++ E++H + K
Sbjct: 525 MWRQEEK-----IREQEEIWRQKEKIH----EQEEKIRKQEEKMWRQEEKMHDQEEKIRE 575
Query: 418 VTSEEWRQ---LQTQAKLVLEENKLLLEQLEI---QQRKAKDSHQERLQEVSKLTKQLML 471
+ WRQ ++ Q + + E+ + + EQ E+ Q+ K + ++ ++ K+ +Q
Sbjct: 576 QEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQ--- 632
Query: 472 LEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKE 531
E K QE+++ E +++ K +E + ++ + + E + ++ ++EEK
Sbjct: 633 -EEKMRRQEEKIREQEKKIREQEEKIREQEE------MMQEQEEKMWEQEEKMCEQEEKM 685
Query: 532 RAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAEL 570
+ + E++ + + Q+ L ++ + E + LEA +
Sbjct: 686 QEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 724
Score = 54.7 bits (130), Expect = 3e-07
Identities = 61/297 (20%), Positives = 144/297 (48%), Gaps = 33/297 (11%)
Query: 448 QRKAKDSHQERLQ-EVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQEL--KTHS 504
++KA HQE L+ E+ + +L + + L ++ ++ L + ++L + H
Sbjct: 171 EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHD 230
Query: 505 DGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNK 564
K A E+ +++ S + +++K +EEL ++ L + + L E+N
Sbjct: 231 SWKFAGELEQAL-----SAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNA 285
Query: 565 ALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMC 624
L+ +L+ + + Q ++ LK+++E+A ++ Q L A+++ +E S+
Sbjct: 286 KLQEKLQLVESEKSEIQLNVKELKRKLERA---KLLLPQ--QQLQAEADHLGKELQSVSA 340
Query: 625 --LAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGK 682
A+ E+E LN+ + ++ + EEK++ +++ K+ + ++ EQ+E K
Sbjct: 341 KLQAQVEENELWNRLNQ--QQEEKMWRQEEKIQEWEE----KIQEQEEKIREQEE----K 390
Query: 683 TAQYRQEMRHLHQVLKDKQEVL----DQALQQNREMEGELEVIWESTFRENRRIREL 735
+ ++MR +++ +K+E + + ++ +M + E++WE + +IREL
Sbjct: 391 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE----KEEKIREL 443
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 87.8 bits (216), Expect = 3e-17
Identities = 124/502 (24%), Positives = 226/502 (45%), Gaps = 52/502 (10%)
Query: 255 QSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPELLYLRKQAQE---L 311
Q LT EL K ++ Q++ +EK++R+ ++E + + E A E L K +E L
Sbjct: 1433 QRLTAELQDTKLHLEGQQVRNHELEKKQRRF-DSELSQAHEEAQREKLQREKLQREKDML 1491
Query: 312 VDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLL 371
+ E LK + +++++ + K L E +I SK + K L L
Sbjct: 1492 LAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQ-DISSQESKDEASLAKVK-KQLRDLEA 1549
Query: 372 AYEDMMKEKDELNAT--------LKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEW 423
+D +E DE T L+ EM M RMR Q KE E +E+ ++ ++
Sbjct: 1550 KVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMR-QTHSKEMESRDEEVEEARQSCQKKL 1608
Query: 424 RQLQTQAKLVLEEN-KLLLEQLEIQQRKAKDSHQ---------ERLQEVSKLTK------ 467
+Q++ Q + E+ K+L E+ E++ + A S Q +RL++ K TK
Sbjct: 1609 KQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADA 1668
Query: 468 QLMLLEAKTHGQEK-ELAENREQLEILRAKCQE-LKTHSDGKIAVE-VH---------KS 515
QLML K K E+A+ + QLE C +K ++ +E +H K+
Sbjct: 1669 QLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKT 1728
Query: 516 IVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQK 575
+ E S+LQ+E+ + + +EE E + L + K+ + + + Q L+A+LE A K
Sbjct: 1729 ALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANK 1788
Query: 576 INRKSQKKIEVLKKQV---EKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESE 632
++ Q+K++ L+ QV E++M ++ + A + L + ER + L
Sbjct: 1789 EKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRL 1848
Query: 633 KDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRH 692
K+ + K+ + + E + K K+ +L D E+ + A K A+ ++
Sbjct: 1849 KEN-MEKLTEERDQRIAAENREKEQNKRLQRQLRDTK----EEMGELARKEAEASRKKHE 1903
Query: 693 LHQVLKDKQEVLDQALQQNREM 714
L L + E +Q+LQ + ++
Sbjct: 1904 LEMDL-ESLEAANQSLQADLKL 1924
Score = 65.5 bits (158), Expect = 2e-10
Identities = 102/470 (21%), Positives = 218/470 (46%), Gaps = 63/470 (13%)
Query: 238 EKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEK-------RKLKEAEK 290
+K +L+ E D+++ L +K+ +++L+ K+K E+E + L++A+
Sbjct: 1514 QKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKL 1573
Query: 291 ASSQEVAAPELLY---LRKQAQELVDENDGLKMTVHRLNVEL-SRYQTKFRHLSKEESL- 345
E+ + + + +E+ + + + ++ V+L Y+ K + L ++ L
Sbjct: 1574 RLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELE 1633
Query: 346 ----------NIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFR 395
N S+ + D+K + LLA +M + + +A K E+ +
Sbjct: 1634 GKLATLSDQVNRRDFESEKRLRK---DLK-RTKALLADAQLMLDHLKNSAPSKREIAQLK 1689
Query: 396 MRVQE-------VVK-------ENEELHQELN---KSSAVTSEEWRQLQTQAKLVLEENK 438
+++E VK E E+LH +++ K+ E+ +LQ + + +N+
Sbjct: 1690 NQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEI--QNR 1747
Query: 439 LLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQ 498
L +Q ++ + K H+ + + S+ Q+ L+A+ KE E +E+L+ L+++ +
Sbjct: 1748 LEEDQEDMNELMKK--HKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVE 1805
Query: 499 ELKTHSDGKIAVEVHKSIVNELKSQLQ------KEEEKERAEMEELMEKLTVLQAQKKSL 552
L+ K V ++ + EL+++L+ K E + ++E MEKLT + Q+
Sbjct: 1806 FLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQR--- 1862
Query: 553 LLEKNSLTEQNKALEAEL-ERAQKINRKSQKKIEVLKKQVEKAMGNEM--SAHQYLANLV 609
+ +N EQNK L+ +L + +++ ++K+ E +K+ E M E +A+Q L +
Sbjct: 1863 IAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADL 1922
Query: 610 GLAENITQERDSLMCLAKCLES-EKDGVLNKVIKSNIRLGKLEEKVKGYK 658
LA + D + +ES E + ++N S++ +LE++V G K
Sbjct: 1923 KLA--FKRIGDLQAAIEDEMESDENEDLINSEGDSDVD-SELEDRVDGVK 1969
Score = 61.2 bits (147), Expect = 3e-09
Identities = 86/440 (19%), Positives = 181/440 (41%), Gaps = 67/440 (15%)
Query: 358 PWLLDIKYLSPLLLAY--EDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKS 415
PW + PL+ E+ ++ KDE E++ R ++++ KE EL ++
Sbjct: 1235 PWWKLFTTVRPLIEVQLSEEQIRNKDE-------EIQQLRSKLEKAEKERNELRLNSDRL 1287
Query: 416 SAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAK 475
+ SE +L T + E LL+ ++ +A+ +E + L KQ+ ++E +
Sbjct: 1288 ESRISELTSEL-TDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEME 1346
Query: 476 TH-------------------GQEKELAENREQLEILRAKCQELKTHSDGKIAVEV-HKS 515
G E L R E+ K + L+ + K+ VE +K
Sbjct: 1347 VMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTK-KRLQQEFEDKLEVEQQNKR 1405
Query: 516 IVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLE-------KNSLTEQNKALEA 568
+ LQ + E+ + +++L +K L A+ + L + L ++ + ++
Sbjct: 1406 QLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDS 1465
Query: 569 ELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLA----NLVGLAENITQERDSLMC 624
EL +A + ++ + + E L+++ + + S Q L ++ G + + L
Sbjct: 1466 ELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQD 1525
Query: 625 LAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDI---------------- 668
++ ES+ + L KV K +L LE KVK +++ + G I
Sbjct: 1526 ISS-QESKDEASLAKVKK---QLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMER 1581
Query: 669 -----SHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWE 723
S + + E+ +++++ + L+++ E + L++ RE+EG+L + +
Sbjct: 1582 MRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSD 1641
Query: 724 STFRENRRIRELLQDTLTRT 743
R + + L+ L RT
Sbjct: 1642 QVNRRDFESEKRLRKDLKRT 1661
Score = 37.7 bits (86), Expect = 0.041
Identities = 48/230 (20%), Positives = 94/230 (40%), Gaps = 36/230 (15%)
Query: 230 QRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKEL------QLKLKGMEKEKR 283
++ + + REK E D +MN+ + + QA ++L Q +L+ KEK+
Sbjct: 1732 EQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQ 1791
Query: 284 KLKEAEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEE 343
+L+E +A +V E Q +VD K V R ++ +T+ + +
Sbjct: 1792 ELQEKLQALQSQVEFLE--------QSMVD-----KSLVSRQEAKIRELETRL-EFERTQ 1837
Query: 344 SLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVK 403
+E L S+ L E + +E+D+ A E R+Q ++
Sbjct: 1838 VKRLESLASR---------------LKENMEKLTEERDQRIAAENREKEQ-NKRLQRQLR 1881
Query: 404 ENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKD 453
+ +E EL + A S + +L+ + + N+ L L++ ++ D
Sbjct: 1882 DTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGD 1931
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 87.4 bits (215), Expect = 5e-17
Identities = 120/539 (22%), Positives = 240/539 (44%), Gaps = 72/539 (13%)
Query: 230 QRYTEITREKFEALKEEN---MDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKR--- 283
Q + E+ EK +KE + L N S+ EL T K+ ++ + L +K E+E +
Sbjct: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626
Query: 284 ---------KLKEAEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQT 334
KL E ++ + Q++AA + L + ++ G + + LN +L +
Sbjct: 1627 DRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERER 1686
Query: 335 KFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDE--LNATLKEEMR 392
+ H+ +E+ ++E S+ I P + + AY + + + + T +E++
Sbjct: 1687 EV-HILEEKLKSVESSQSETLIVP------RSAKNVAAYTEQEEADSQGCVQKTYEEKIS 1739
Query: 393 MFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAK 452
+ + + E K + + QE K V+S + Q Q +L+ LE E +Q + +
Sbjct: 1740 VLQRNLTEKEKLLQRVGQE--KEETVSSHFEMRCQYQERLIK------LEHAEAKQHEDQ 1791
Query: 453 DSHQERLQEVSKLTKQLMLLEAKTHGQE--KELAENREQLEILRAKCQELKTHSDGKIAV 510
+E+ + K+ L+ A+ +E K + ++ LE + Q KT + ++
Sbjct: 1792 SMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQ--KTLQEKELTC 1849
Query: 511 EVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQA-------QKKSLLLEKN------ 557
++ + + EL S L +++E R EMEEL K LQA K + LLE+N
Sbjct: 1850 QILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSK 1909
Query: 558 ----------SLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLAN 607
++ Q+ LE +L A++ +K K+I L+K + M ++
Sbjct: 1910 SHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDL------RMLRKEHQQE 1963
Query: 608 LVGLAENITQER-DSLMCLAKCLESEKDGVLNKVIKS-NIRLGKLEEKVKGYKKQAALKL 665
L L + QER + + + LE + + L ++++ N +L + E++++ K+ K
Sbjct: 1964 LEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKA 2023
Query: 666 GDISHRLLE-QQEDFAGKTAQYRQEMRHLHQVLKDKQEVLD----QALQQNREMEGELE 719
++ LLE QE+ + ++ L + K +E+LD + + R+++ +LE
Sbjct: 2024 QEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLE 2082
Score = 78.2 bits (191), Expect = 3e-14
Identities = 115/510 (22%), Positives = 231/510 (45%), Gaps = 77/510 (15%)
Query: 244 KEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPELLY 303
KEEN + + +E T + ++ LQ ++K E ++ KE ++ ++ LL
Sbjct: 260 KEENPESDG---EPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCT---LLT 313
Query: 304 LRKQA-QELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLD 362
K+A QE +DE + + L K + L+ + K + L D
Sbjct: 314 SEKEALQEQLDE--------------------RLQELEKIKDLH---MAEKTKLITQLRD 350
Query: 363 IKYLSPLLLAYEDMM--KEKDELNATLK---EEMRMFRMRVQEVVKENEELHQELNKSSA 417
K L L + M+ + K +++ TL+ EE+ R R++++ + EEL ++ KS
Sbjct: 351 AKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSER 410
Query: 418 VTSEEW-RQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERL---QEVSKLTKQLMLLE 473
EE + L T K KL E E + K S +ER+ QE+S++ ++++ +
Sbjct: 411 AAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVM 470
Query: 474 AKTHGQ---------EKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQL 524
K+ + EKELA ++L + + +E + K+A+E +S E
Sbjct: 471 KKSSEEQIAKLQKLHEKELARKEQEL-TKKLQTREREFQEQMKVALEKSQS---EYLKIS 526
Query: 525 QKEEEKERAEMEELMEKLTVLQAQKKSLLLE-KNSLTEQNKALEAELERAQKINRKSQKK 583
Q++E++E +EE L+ QKK++L E +N L + + E R ++ +K
Sbjct: 527 QEKEQQESLALEE-------LELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKS 579
Query: 584 IEVLKKQ-VEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIK 642
++ K Q + A+ E +++ + + E E +SL L +EK VL + +
Sbjct: 580 LQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQ 639
Query: 643 SNIRLGKLEEKVKGYKKQAALK---------LGDISHRLLE----QQEDFAGKTAQYRQE 689
+ + KL EK + +K+ LK + +++ + LE +Q + +++ +
Sbjct: 640 TEME--KLREKCE-QEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEV 696
Query: 690 MRHLHQVLKDKQEVLDQALQQNREMEGELE 719
++ H++ ++ + DQ + +E+E +++
Sbjct: 697 LKARHKLEEELSVLKDQTDKMKQELEAKMD 726
Score = 71.6 bits (174), Expect = 3e-12
Identities = 116/517 (22%), Positives = 215/517 (41%), Gaps = 81/517 (15%)
Query: 245 EENMDLNNMNQSLTLELNTMKQAM-----KELQLKLKGMEKEKRKLKEAEKASSQEVAAP 299
+ N ++ M + EL ++K ++LQ+ + + E KL+E + + +
Sbjct: 600 KHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKD 659
Query: 300 ELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPW 359
+ + + +E+ ++ T+ +L+V+ QT+ LS E S E L ++ +
Sbjct: 660 KEIIFQAHIEEMNEK------TLEKLDVK----QTELESLSSELS---EVLKARHKLEEE 706
Query: 360 LLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVT 419
L +K + K K EL A + E+ + +V ++KE+E Q K+
Sbjct: 707 LSVLK---------DQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQ 757
Query: 420 SEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQ 479
+ L + L+E++ +E LE +++ + LQ+ S ++ TH Q
Sbjct: 758 INQLELLLKERDKHLKEHQAHVENLEADIKRS----EGELQQASAKLDVFQSYQSATHEQ 813
Query: 480 EKELAENREQLEILRAKCQELKTH---------------SDGKIAVEVHKSIVNELKSQL 524
K EQL L+ K +L+T D ++ HK V +L QL
Sbjct: 814 TKAY---EEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQL 870
Query: 525 QKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKK- 583
EK+ +EME+ ++ LT + K L + N EQ K + E E R+ QKK
Sbjct: 871 ----EKQNSEMEQKVKSLTQVYESK---LEDGNKEQEQTKQILVEKENMILQMREGQKKE 923
Query: 584 IEVLKKQVEKAMGNEMSAH----QY---LANLVGLAENITQERDSLMCLAKCLESEKDGV 636
IE+L +K E S H +Y N E + Q+ + K +++
Sbjct: 924 IEIL---TQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAK 980
Query: 637 LNKVIKSN-IRLGKLEEKVKGYKKQAA----LKLGDISHRL-LEQQEDFAGKTAQYRQEM 690
L K +++ + L + E++ + A + D RL Q+E T +R+E+
Sbjct: 981 LKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRREL 1040
Query: 691 --------RHLHQVLKDKQEVLDQALQQNREMEGELE 719
+ L+Q ++ QE+ + LQ+ + EL+
Sbjct: 1041 NDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELK 1077
Score = 68.9 bits (167), Expect = 2e-11
Identities = 142/704 (20%), Positives = 289/704 (41%), Gaps = 139/704 (19%)
Query: 128 DIETQLSSSGKELGDVSAREDRGGHSDDLYAVPHRNQVPLLHEVNSEDDENISHQDGFPG 187
D+ET+ K++ +V A++ D + + ++ + L + NSE ++ +
Sbjct: 830 DLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYE 889
Query: 188 SPPAPQRTQQKDGKHPVLNLKDEKPPLCEKPPPSPDITGRARQRYTEITREKFEALKEEN 247
S +Q+ K ++ ++ + E +++ EI +K A KE++
Sbjct: 890 SKLEDGNKEQEQTKQILVEKENMILQMRE-----------GQKKEIEILTQKLSA-KEDS 937
Query: 248 MDLNN-------MNQSLTLELNTMKQAMKELQ--LKLKGMEKEKRKLKEAEKASSQEVAA 298
+ + N NQ +E +KQ KE+Q LK K +++E + KE E ++ E++
Sbjct: 938 IHILNEEYETKFKNQEKKME--KVKQKAKEMQETLKKKLLDQEAKLKKELEN-TALELSQ 994
Query: 299 PELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPP 358
E + K + + G+ V RL + + E ++ I
Sbjct: 995 KEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDV--------ISI 1046
Query: 359 WLLDI-KYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSA 417
W + + L +E ++EK++ A LK+++ +F +E+ KE L +E K
Sbjct: 1047 WEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDT 1106
Query: 418 VTSEEWRQLQTQA----KLVLEENKLL--LEQLEIQQRKAKDSH---QERLQE------- 461
+E QL+ ++ L +E KL LE+LE+ K+ + QE+L E
Sbjct: 1107 TLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEE 1166
Query: 462 ----VSKLTKQLMLLEAKTHGQEKELAENREQLE-------------------------- 491
VS+LT +L + + + ++ + LE
Sbjct: 1167 DKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEA 1226
Query: 492 ILRAKCQELKTHSDGKI-------------------AVEVHKSIVNELKSQLQKEEEKER 532
+L AK EL S K A+ + V+EL++QL++ E++
Sbjct: 1227 LLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQN 1286
Query: 533 A---EMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKK 589
++ +L + Q KS+ + SL + +AL+ E Q+ + + I LKK
Sbjct: 1287 TLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKK 1346
Query: 590 QVEKAMGNEMSAHQYLANLVGL-AENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLG 648
++ + + N V L E + +++ + L+K L LN ++++I L
Sbjct: 1347 ELSENI-----------NAVTLMKEELKEKKVEISSLSKQLTD-----LNVQLQNSISLS 1390
Query: 649 KLEEKVKGYKKQ--------------AALKLGDISHR---LLEQQEDFAGKTAQYRQEMR 691
+ E + +KQ + K+ +S LEQ +D++ K ++++++ +
Sbjct: 1391 EKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQ 1450
Query: 692 H---LHQ-VLKDKQEVLDQALQQNREMEGELEVIWESTFRENRR 731
HQ +K+ Q L+ ++ E + ++ ++ E ++N+R
Sbjct: 1451 SRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKR 1494
Score = 68.6 bits (166), Expect = 2e-11
Identities = 110/517 (21%), Positives = 225/517 (43%), Gaps = 75/517 (14%)
Query: 229 RQRYTEITREKFEALKEENMDLNN-MNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKE 287
R +Y+E+ ++ L+ E L ++QS L + + +ELQ M+++ +K +
Sbjct: 154 RGKYSELVTA-YQMLQREKKKLQGILSQSQDKSLRRIAELREELQ-----MDQQAKKHLQ 207
Query: 288 AEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNI 347
E +S E + L+ Q L M V L L + + + +KEE+
Sbjct: 208 EEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLK-PLPQLEPQAEVFTKEENPES 266
Query: 348 EGLPSKGPIPPWLLDIKYLSPL---LLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKE 404
+G P+ +K L L + E+++K E + KE+ + + + ++
Sbjct: 267 DG----EPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQ 322
Query: 405 NEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSK 464
+E QEL K + E +L TQ L + K L+EQLE Q++ +++
Sbjct: 323 LDERLQELEKIKDLHMAEKTKLITQ----LRDAKNLIEQLE----------QDKGMVIAE 368
Query: 465 LTKQLM-LLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQ 523
+Q+ LE K E+E+A+ R +++ + + +EL+
Sbjct: 369 TKRQMHETLEMK----EEEIAQLRSRIKQMTTQGEELR---------------------- 402
Query: 524 LQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALE--AELERA---QKINR 578
+++E+ ERA EEL + L+ Q +++ K + EQ K +E +E ER Q+++R
Sbjct: 403 -EQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSR 461
Query: 579 KSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLN 638
Q+ ++V+KK E+ + H+ L + +T++ L + + + L
Sbjct: 462 VKQEVVDVMKKSSEEQIAKLQKLHE--KELARKEQELTKK---LQTREREFQEQMKVALE 516
Query: 639 KVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLK 698
K +++ + +E+ Q +L L ++ + + K +QE +
Sbjct: 517 KSQSEYLKISQEKEQ------QESLALEELELQKKAILTESENKLRDLQQEAETYRTRIL 570
Query: 699 DKQEVLDQALQQNREMEGELEVIWESTFRENRRIREL 735
+ + L+++LQ+N+ +L V E+ +N+ +E+
Sbjct: 571 ELESSLEKSLQENKNQSKDLAVHLEA--EKNKHNKEI 605
Score = 66.2 bits (160), Expect = 1e-10
Identities = 126/569 (22%), Positives = 241/569 (42%), Gaps = 82/569 (14%)
Query: 243 LKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPELL 302
L EE LN Q T +L + +K ++ ++ + EK L++ + +Q+ AA E
Sbjct: 1281 LTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQK--EGGNQQQAASEKE 1338
Query: 303 YLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKE-ESLNIEGLPSKGPIPPWLL 361
Q ++ + EN V + EL + + LSK+ LN++ L
Sbjct: 1339 SCITQLKKELSENIN---AVTLMKEELKEKKVEISSLSKQLTDLNVQ-----------LQ 1384
Query: 362 DIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSE 421
+ LS A + K+ DE L ++++ +V + KE ++++ S SE
Sbjct: 1385 NSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSE 1444
Query: 422 EWR-------------------QLQTQAKLVLEENK---LLLEQLEIQQRKAKDSHQERL 459
W+ QL+ ++K E+++ LL E+L+ Q ++ E
Sbjct: 1445 -WKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEME 1503
Query: 460 QEVSKLTKQLMLLEAKTHGQE---KELAENREQLEILRAKCQELKTHSDGKIAVEVHKSI 516
+ SK+ K+ LE + Q EL ++ Q I E+ + + + +E HK +
Sbjct: 1504 DDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIE-HKEL 1562
Query: 517 VNELKSQLQKEEEKERAEMEELMEKLTVLQAQ-----------KKSL---LLEKNSLTEQ 562
V +L+ + EEK+ ++E EK+ L+ Q KK L L S E+
Sbjct: 1563 VQKLQHFQELGEEKDN-RVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEE 1621
Query: 563 NKALEAELE-----RAQKINRKSQKKIEVLKKQV-----EKAMGNEMSAHQYLANLVGLA 612
KALE LE + ++ RK+++KI +KKQ+ EK + +L+ L
Sbjct: 1622 LKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKL 1681
Query: 613 ENITQERDSLMCLAKCLESEKDG--VLNKVIKSNIRLGKLEEK------VKGYKKQAALK 664
+ +E L K +ES + ++ + K+ + EE K Y+++ ++
Sbjct: 1682 QEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVL 1741
Query: 665 LGDIS--HRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIW 722
+++ +LL++ +T EMR +Q K E + +++ M G L+
Sbjct: 1742 QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQ--- 1798
Query: 723 ESTFRENRRIRELLQDTLTRTGVQDNPRA 751
E +N++ ++ + + G ++N +A
Sbjct: 1799 EELEEKNKKYSLIVAQHVEKEGGKNNIQA 1827
Score = 57.4 bits (137), Expect = 5e-08
Identities = 111/539 (20%), Positives = 216/539 (40%), Gaps = 69/539 (12%)
Query: 235 ITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQL--KLKGMEKEKRKLKEAEKAS 292
+ +E+ + LKE + N+ + ++QA +L + + E+ K E + A
Sbjct: 764 LLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQ 823
Query: 293 SQEVAAP---ELLYLRKQAQELVDENDGL--KMTVHRLNVELSRYQTKFRHLSKEESLNI 347
Q+ E + L KQ E+ + + ++ H++ V Q + L K+ S
Sbjct: 824 LQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQV-----QDLMQQLEKQNSEME 878
Query: 348 EGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEE 407
+ + S + Y S L ED KE+++ L E+ M + KE E
Sbjct: 879 QKVKSLTQV--------YESKL----EDGNKEQEQTKQILVEKENMILQMREGQKKEIEI 926
Query: 408 LHQELNK---SSAVTSEEWR-QLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVS 463
L Q+L+ S + +EE+ + + Q K + + + E E ++K D + +E+
Sbjct: 927 LTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELE 986
Query: 464 KLTKQLMLLEAKTHGQEKELAE----------------NREQLEILRA----------KC 497
+L E + + + E+A+ +EQ+E L
Sbjct: 987 NTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISI 1046
Query: 498 QELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKER---AEMEELMEKLTVLQAQKKSLLL 554
E K + + E+H+ + E + ++ + ++K E EE+ +++T L+ +
Sbjct: 1047 WEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDT 1106
Query: 555 EKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAEN 614
N L EQ K A + + K + +E L+ + K++ + L L LAE
Sbjct: 1107 TLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEE 1166
Query: 615 ITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDI----SH 670
++ L K + E + + KSN L + K ++ A++L DI +
Sbjct: 1167 DKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQL-DICCKKTE 1225
Query: 671 RLLEQQED-----FAGKTAQYRQEMRHL-HQVLKDKQEVLDQALQQNREMEGELEVIWE 723
LLE + + + KT + H H+ K K+ +L + + E+E +L + E
Sbjct: 1226 ALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVS-ELEAQLRQLTE 1283
Score = 53.9 bits (128), Expect = 6e-07
Identities = 92/503 (18%), Positives = 209/503 (41%), Gaps = 78/503 (15%)
Query: 243 LKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPELL 302
+KE + + ++L ++N ++ +KE LK + L+ K S E+
Sbjct: 740 IKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGEL------ 793
Query: 303 YLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLD 362
+QA +D + H + Y+ + L +++ L++E +L
Sbjct: 794 ---QQASAKLDVFQSYQSATHE---QTKAYEEQLAQL-QQKLLDLE--------TERILL 838
Query: 363 IKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTS-- 420
K ++ + +D+ E D +++ M Q++ K+N E+ Q++ + V
Sbjct: 839 TKQVAEVEAQKKDVCTELDAHKIQVQDLM-------QQLEKQNSEMEQKVKSLTQVYESK 891
Query: 421 -EEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTH-- 477
E+ + Q Q K +L E + ++ Q+ Q+K E+ LT++L E H
Sbjct: 892 LEDGNKEQEQTKQILVEKENMILQMREGQKK----------EIEILTQKLSAKEDSIHIL 941
Query: 478 --GQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEM 535
E + +++E ++ K +E++ LK +L +E K + E+
Sbjct: 942 NEEYETKFKNQEKKMEKVKQKAKEMQ----------------ETLKKKLLDQEAKLKKEL 985
Query: 536 EELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAM 595
E +L+ + Q + +LE + + N A ++ + N+K Q IE L + + +
Sbjct: 986 ENTALELSQKEKQFNAKMLE---MAQANSAGISDAVSRLETNQKEQ--IESLTEVHRREL 1040
Query: 596 GNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVK 655
+ +S + + + Q+ + L + + EK+ + ++ + + G +E++
Sbjct: 1041 NDVISIWE---------KKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMN 1091
Query: 656 ---GYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNR 712
+ K+ +K + L EQ + + Q+ L L+ + L+++L++N
Sbjct: 1092 KEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENT 1151
Query: 713 EMEGELEVIWESTFRENRRIREL 735
++ +L + + R++ EL
Sbjct: 1152 FLQEQLVELKMLAEEDKRKVSEL 1174
Score = 42.4 bits (98), Expect = 0.002
Identities = 69/339 (20%), Positives = 143/339 (42%), Gaps = 38/339 (11%)
Query: 415 SSAVTSEEWRQLQTQAK-LVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLE 473
SS + + + ++A+ LV + L EQL + R+ + S + S+L +L+
Sbjct: 109 SSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQ 168
Query: 474 AK--------THGQEKEL---AENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKS 522
+ + Q+K L AE RE+L++ + + L+ D + + V + +
Sbjct: 169 REKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQV 228
Query: 523 QLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQK 582
L K+ + ++++ L L+ Q + E+N ++ +E + S K
Sbjct: 229 SLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVE---------DGTSVK 279
Query: 583 KIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIK 642
+E L+++V++ NL+ + Q L L SEK+ + ++ +
Sbjct: 280 TLETLQQRVKRQ-----------ENLLKRCKETIQSHKEQCTL---LTSEKEALQEQLDE 325
Query: 643 SNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQE 702
L K+++ K + +L D + L+EQ E G + R +H+ L+ K+E
Sbjct: 326 RLQELEKIKDLHMAEKTKLITQLRDAKN-LIEQLEQDKGMVIA--ETKRQMHETLEMKEE 382
Query: 703 VLDQALQQNREMEGELEVIWESTFRENRRIRELLQDTLT 741
+ Q + ++M + E + E + R E L+ L+
Sbjct: 383 EIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALS 421
Score = 38.5 bits (88), Expect = 0.024
Identities = 109/546 (19%), Positives = 203/546 (37%), Gaps = 136/546 (24%)
Query: 174 EDDENISHQDGFPGSPPAPQRTQQKDGKHPVLNLKDEKPPL--------CEKPPPSPDIT 225
E +E I + S A T++K+ +H L++K ++ L E ++
Sbjct: 1582 EAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELK 1641
Query: 226 GRARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKE----LQLKLKGMEKE 281
+A Q+ I ++ ++E+ +S ELNT Q + L+ KLK +E
Sbjct: 1642 RKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESS 1701
Query: 282 K----------------------------------------RKLKEAEK-----ASSQEV 296
+ R L E EK +E
Sbjct: 1702 QSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEE 1761
Query: 297 AAPELLYLRKQAQELVDENDGLKMTVHR-------LNVELSRYQTKF-----RHLSKEES 344
+R Q QE + + + + H L EL K+ +H+ KE
Sbjct: 1762 TVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGG 1821
Query: 345 LNIEGLPSKGPIPPWLLDI-KYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVK 403
N + +K + D+ K L L + + ++ EL++ L + + R+ ++E+
Sbjct: 1822 KN--NIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTS 1879
Query: 404 ENEELH--QELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQ------LEIQQRKAKDSH 455
+ E+L Q+++ + T + ++K L + KLL LE + A+
Sbjct: 1880 KYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREK 1939
Query: 456 QERLQEVSKLTKQLMLLEA----------KTHGQEKE--LAENREQLEI----------- 492
Q+ +E+ +L K L +L K + QE+E + + +E LE+
Sbjct: 1940 QKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMR 1999
Query: 493 -----LRAKCQELKTHSDGKI---------AVEVHKSIVNELKSQL-QKEEEKER----- 532
L K QEL+ I +E H+ N+L ++ +K+++ +R
Sbjct: 2000 EFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRY 2059
Query: 533 -----AEMEELMEKLTVLQAQ--------KKSLLLEKNSLTEQNKALEAELERAQKINRK 579
A EE+ K+ LQ Q ++ L E+N + +E + + AQK
Sbjct: 2060 EEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLI 2119
Query: 580 SQKKIE 585
S K++
Sbjct: 2120 SDSKLK 2125
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 87.0 bits (214), Expect = 6e-17
Identities = 122/509 (23%), Positives = 231/509 (45%), Gaps = 72/509 (14%)
Query: 229 RQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEA 288
+++ E + + E + E+ L + + L+ E +++ + KL + KR L A
Sbjct: 1757 QKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLA---QTKRVLAAA 1813
Query: 289 EKASSQEVAAPELLYL--RKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLN 346
E+ S E + E L L RK QEL D+ + K+++H ++S Q + + K E++N
Sbjct: 1814 EENSKMEQSNLEKLELNVRKLQQEL-DQLNRDKLSLHN---DISAMQQQLQE--KREAVN 1867
Query: 347 IEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENE 406
+ L +++ L LA +D++ + L E+ R+ Q+ + E
Sbjct: 1868 --------SLQEELANVQ--DHLNLAKQDLLHTTKHQDVLLSEQTRL-----QKDISEWA 1912
Query: 407 ELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLT 466
++ K ++ + LQ + +EENKL L Q E+ ++ + +ER E SKL
Sbjct: 1913 NRFEDCQKEEETKQQQLQVLQNE----IEENKLKLVQQEMMFQRLQ---KERESEESKLE 1965
Query: 467 KQLMLLEAKTHGQEKELAENREQLEILRAKC----QELKTHSDGKIAVEVHKSIVNELKS 522
+ L+ + H EKEL + + +L+ + +K + ++T + + E + +++ K
Sbjct: 1966 TSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKR 2025
Query: 523 QLQKEEEKERAEMEELMEKLTVLQAQKKSL-----LLEKNSLTEQNKALE--AELERAQK 575
QL + E+ ++ E +L LQ + S+ LL LTE+ KA + A L+ A K
Sbjct: 2026 QLSEREQ----QLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALK 2081
Query: 576 INRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDG 635
I R +K + +KQ + EM+ + L ER A+ L E
Sbjct: 2082 IQRSQLEKNLLEQKQENSCIQKEMAT-------IELVAQDNHER------ARRLMKE--- 2125
Query: 636 VLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQ 695
LN++ L K K +++ +++ D L + +D + R +++L+Q
Sbjct: 2126 -LNQMQYEYTELKKQMANQKDLERRQ-MEISDAMRTLKSEVKD------EIRTSLKNLNQ 2177
Query: 696 VLKDKQEVLDQALQQNREMEGELEVIWES 724
L + L+ L++N +EGELE + E+
Sbjct: 2178 FLPELPADLEAILERNENLEGELESLKEN 2206
Score = 70.9 bits (172), Expect = 4e-12
Identities = 119/605 (19%), Positives = 260/605 (42%), Gaps = 71/605 (11%)
Query: 159 VPHRNQVPLLHEVNSEDDENISHQDGFPGSPPAPQRTQQKDGKHPVLNLKDEKPPLCEKP 218
+PH Q + H + E E G P Q Q+ + + ++ + L +K
Sbjct: 233 LPHYLQFTIFHLRSLESLE---------GQPVTTQDRQEAFERFSLEEVERLERDLEKKM 283
Query: 219 PPSPDITGRARQRYTEITREKF--EALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLK 276
+ ++ + + EI + ++LKEE M + L +LNT + +K+ ++L
Sbjct: 284 IETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELT 343
Query: 277 GMEKEKRKLKEAEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKF 336
+++ +L++ + L Y + E +D+ + + + + + T+
Sbjct: 344 RACQKQYELEQELAFYKIDAKFEPLNYYPSEYAE-IDKAPDESPYIGKSRYKRNMFATES 402
Query: 337 RHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRM 396
+ +++ I+ + + ++++ +PL ED KEK ++ +
Sbjct: 403 YIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLED--KEK---------KISAAQT 451
Query: 397 RVQEVVKENEELHQELNKSSAVTSEEWRQLQT--QAKLVLEENK-LLLEQLEIQQRKAKD 453
R+ E+ E E+ Q++ +++ EE++QL+ Q K + E K LL +QL
Sbjct: 452 RLSELHDEIEKAEQQILRAT----EEFKQLEEAIQLKKISEAGKDLLYKQLS-------- 499
Query: 454 SHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVH 513
RLQ V+KL ++ + LE + Q++E+A +++++ L+ L + ++
Sbjct: 500 ---GRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQ 556
Query: 514 KSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTE----QNKALEAE 569
KS + + K+ ++ + ++E++ ++ + K L + LTE N+AL+ +
Sbjct: 557 KSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDL---EEQLTEGQIAANEALKKD 613
Query: 570 LERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCL 629
LE + Q+ + +K Q +A L+ + QERD L +A
Sbjct: 614 LE---GVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDA 670
Query: 630 E------SEKDGVLNKVIKSNIRLGKLEEKVKGYKK--QAALKLGDISHRLLEQQEDFAG 681
E +E + L + + N L + + + Y+ +A L L D L+++ +
Sbjct: 671 ENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVT 730
Query: 682 KTAQYRQ-----EMRHLHQVLKD---KQEVLDQALQQNREMEGELEVIWESTFRENRRIR 733
+ Q Q E+ Q LK+ K + ++ Q+N E+ +L+ + + +N ++
Sbjct: 731 RLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQD----DNNLLK 786
Query: 734 ELLQD 738
+ L+D
Sbjct: 787 QQLKD 791
Score = 68.2 bits (165), Expect = 3e-11
Identities = 84/388 (21%), Positives = 172/388 (44%), Gaps = 71/388 (18%)
Query: 388 KEEMRMFRMRVQEVVKENEELHQELN------KSSAVTSEEWR---QLQTQAKLVLEEN- 437
K E R R ++ KE EELH ++ KS EE Q + Q K ++ N
Sbjct: 1339 KREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNV 1398
Query: 438 KLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKC 497
+ L+ +LEI+ K+ H++ + E+ + K L+ ++ ++ LAE +L + K
Sbjct: 1399 ESLMTELEIE--KSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKT 1456
Query: 498 QE------------LKTHSDG-KIAVEVHKSIVNELKSQLQ--------KEEEKERAEME 536
+ L+T SD ++ ++ VN +K+ Q K+ E+ + + E
Sbjct: 1457 KNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQE 1516
Query: 537 ELMEKLTVLQAQKKS----LLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVE 592
E+++++ + A K S L +K LTE+ + L+ ++E A+ R ++VLK+
Sbjct: 1517 EILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAE---RNEDHHLQVLKE--- 1570
Query: 593 KAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGV---------LNKVIKS 643
+E+ A L L +T ++ + L + L +K+ + ++
Sbjct: 1571 ----SEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQE 1626
Query: 644 NIRLGKLE--------EKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQ 695
+RLG+ E +VK ++ + + G+++ ++ E++ + +E +L
Sbjct: 1627 ALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQV 1686
Query: 696 VLK-------DKQEVLDQALQQNREMEG 716
VL+ + + +LD +N E++G
Sbjct: 1687 VLRQMSKHKTELKNILDMLQLENHELQG 1714
Score = 65.1 bits (157), Expect = 2e-10
Identities = 115/552 (20%), Positives = 238/552 (43%), Gaps = 85/552 (15%)
Query: 201 KHPVLNLKDEKPPLCEKPPPSPDITGRARQRYTEITREKFEALKEENMDLNNMNQSLTLE 260
K+ V D K L + + ++ RA++ + + + L+ D ++ Q +
Sbjct: 1457 KNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKAD-QQLRSLQADAKDLEQHKIKQ 1515
Query: 261 LNTMKQAMKELQLK---LKGMEKEKRKLKEAEKASSQEVAAPEL-----LYLRKQAQELV 312
+K+ K + K + + K+K KL E + +++ E L + K+++ L+
Sbjct: 1516 EEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLL 1575
Query: 313 D----ENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEG--LPSKGPIPPWLL----- 361
E + LK V E++ + H KEE ++G + +K + L
Sbjct: 1576 QAKRAELEKLKSQVTSQQQEMAVLDRQLGH-KKEELHLLQGSMVQAKADLQEALRLGETE 1634
Query: 362 ---DIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAV 418
++ + E++ +K ELN + E + QE+ KE E L L + S
Sbjct: 1635 VTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMS-- 1692
Query: 419 TSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHG 478
+ +T+ K +L+ L LE E+Q K + H +R+ E+ K Q+ +LE
Sbjct: 1693 ------KHKTELKNILD--MLQLENHELQGLKLQ--HDQRVSELEK--TQVAVLE----- 1735
Query: 479 QEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERA----- 533
EK EN +Q+ K +E K ++ K ++++ + RA
Sbjct: 1736 -EKLELENLQQIS------------QQQKGEIEWQKQLLERDKREIERMTAESRALQSCV 1782
Query: 534 -----EMEELMEKLTVLQ---AQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIE 585
E E+L EK + + AQ K +L + E +K ++ LE+ + RK Q++++
Sbjct: 1783 ECLSKEKEDLQEKCDIWEKKLAQTKRVLA---AAEENSKMEQSNLEKLELNVRKLQQELD 1839
Query: 586 VLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNI 645
L + + ++ N++SA Q + + ++R+++ L + L + +D LN + +
Sbjct: 1840 QLNRD-KLSLHNDISAMQ---------QQLQEKREAVNSLQEELANVQDH-LNLAKQDLL 1888
Query: 646 RLGKLEEKVKGYKKQAALKLGDISHRL--LEQQEDFAGKTAQYRQEMRHLHQVLKDKQEV 703
K ++ + + + + + ++R +++E+ + Q Q +++ +QE+
Sbjct: 1889 HTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEM 1948
Query: 704 LDQALQQNREME 715
+ Q LQ+ RE E
Sbjct: 1949 MFQRLQKERESE 1960
Score = 54.7 bits (130), Expect = 3e-07
Identities = 80/397 (20%), Positives = 159/397 (40%), Gaps = 58/397 (14%)
Query: 237 REKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKE--AEKASSQ 294
+++ + L + + L+N ++ +L ++A+ LQ +L ++ K+ Q
Sbjct: 1835 QQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQ 1894
Query: 295 EVAAPELLYLRKQAQELVDENDG--------------LKMTVHRLNVELSRYQTKFRHLS 340
+V E L+K E + + L+ + ++L + + F+ L
Sbjct: 1895 DVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQ 1954
Query: 341 KE--------ESLNIEGLPSKGPIPPWLLDIK-----YLSPLLLAYEDMMKEKDE----- 382
KE E+ + + + L D K LS +L A E + ++E
Sbjct: 1955 KERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCE 2014
Query: 383 -LNATLKEEMRMFRMRVQEVVKENEEL---HQELNKSSAVTSEEWRQLQTQAKLVLEENK 438
L TL + R R Q++V+++ EL +E + A S Q T+ K ++
Sbjct: 2015 SLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA 2074
Query: 439 LLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQ 498
L E L+IQ+ + + + E+ QE S + K++ +E +N E+ L +
Sbjct: 2075 SLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQ-------DNHERARRLMKELN 2127
Query: 499 ELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNS 558
+++ ELK Q+ +++ ER +ME T+ K + +
Sbjct: 2128 QMQYE-------------YTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKN 2174
Query: 559 LTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAM 595
L + L A+LE + N + ++E LK+ + M
Sbjct: 2175 LNQFLPELPADLEAILERNENLEGELESLKENLPFTM 2211
Score = 50.1 bits (118), Expect = 8e-06
Identities = 94/456 (20%), Positives = 190/456 (41%), Gaps = 64/456 (14%)
Query: 223 DITGRARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMK-ELQLKLKGMEKE 281
DI + Q+ E + +E ++ ++ + LT +A+K +L+ + G+++
Sbjct: 565 DIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEY 624
Query: 282 KRKLK-EAEKASSQ-EVAAPELLYLRKQAQELVDENDGLK---MTVHRLNVELSRYQTKF 336
+K +A +A ++ E L ++ E+ E D L+ M + EL+ ++
Sbjct: 625 LGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESA- 683
Query: 337 RHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRM 396
L ++ +N ++G + + +++ L A + +KE+ E T ++ +
Sbjct: 684 --LQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELE-KVTRLTQLEQSAL 740
Query: 397 RVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKL--VLEENKLLLEQLEIQQRKAKD- 453
+ E+ KE + L L K+ +E + AKL + ++N LL +QL+ Q
Sbjct: 741 QA-ELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHV 799
Query: 454 -----SHQERLQEVSKLTKQLMLL--EAKTHGQE----KELAE--------------NRE 488
+E V +L ++L L E H K LA+ R+
Sbjct: 800 VDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERD 859
Query: 489 QLEILRAKCQELKTHSDGKIAV---EVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVL 545
+ ++ K QE K+A E ++ L++++ ++ + A ++++ ++ L
Sbjct: 860 EAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYL 919
Query: 546 QAQKKSL----------LLEKNSLTEQNKALEAELERAQKI-NRKSQKKIEVLKKQVEK- 593
Q KS+ L E + E+ A ELE+ +K+ + KSQ+++ L K+++K
Sbjct: 920 QENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKL 979
Query: 594 ----------AMGNEMSAHQYLANLVGLAENITQER 619
A A L +L G I QER
Sbjct: 980 KKAVATSDKLATAELTIAKDQLKSLHGTVMKINQER 1015
Score = 47.0 bits (110), Expect = 7e-05
Identities = 83/411 (20%), Positives = 157/411 (38%), Gaps = 63/411 (15%)
Query: 241 EALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLK--------------GMEKEKRKLK 286
E ++EN +L+ + L + N +KQ +K+ Q L +++ +RKLK
Sbjct: 762 EEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLK 821
Query: 287 ----EAEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKE 342
E S +V L L+KQ E+ + R E Q + R L +E
Sbjct: 822 LGTGEMNIHSPSDVLGKSLADLQKQFSEI----------LARSKWERDEAQVRERKLQEE 871
Query: 343 ESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDE-LNATLKEEMRMFRMRVQEV 401
+L E L + E+ + + L A + + R R+Q++
Sbjct: 872 MALQQEKLAT-------------------GQEEFRQACERALEARMNFDKRQHEARIQQM 912
Query: 402 VKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQE 461
E L + L + QLQ EE + +L QL ++K K + ++
Sbjct: 913 ENEIHYLQENLKSMEEIQGLTDLQLQEAD----EEKERILAQLRELEKKKKLEDAKSQEQ 968
Query: 462 VSKLTKQLMLLEAKTHGQEK----ELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIV 517
V L K+L L+ +K EL ++QL+ L ++ ++ S
Sbjct: 969 VFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFS-- 1026
Query: 518 NELKSQLQKEEEKERAEME-ELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKI 576
+ Q + RAE E EL++ L + ++ L +EK + + E+E+ +
Sbjct: 1027 ---RKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNET 1083
Query: 577 NRKSQKKIEVLKKQVE-KAMGNEMSAHQYLANLVGLAENITQERDSLMCLA 626
+ + +I L+ ++ N+ L + L ++ + D + +A
Sbjct: 1084 MERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMA 1134
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 85.5 bits (210), Expect = 2e-16
Identities = 104/508 (20%), Positives = 228/508 (44%), Gaps = 42/508 (8%)
Query: 241 EALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPE 300
E LKE+N L Q + E + ++ +KEL+ KL E+ K L + + + + E
Sbjct: 217 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKL---ERAKLLLPQQQLQAEADHLGKE 273
Query: 301 LLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGL-PSKGPIPPW 359
L + + Q V+EN+ + ++ R + K + ++ E + + I
Sbjct: 274 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 333
Query: 360 LLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVT 419
++ ++ E+ M+ ++E+ +E+MR R +E++ E EE + +
Sbjct: 334 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR----RQEEMMWEKEEKMRRQEEMMWEK 389
Query: 420 SEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQE------------------ 461
E+ R+L+ + + E + + EQ E +Q + K QE+ QE
Sbjct: 390 EEKIRELEEK----MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 445
Query: 462 VSKLTKQLMLLEAKTHGQEK--ELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNE 519
+ + K++ E K H QEK E + +EQ E+ R QE K H +I + K ++E
Sbjct: 446 IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWR---QEEKIHEQEEIWRQKEK--MHE 500
Query: 520 LKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKAL--EAELERAQKI- 576
+ +++K+EEK + E++ E+ ++ Q++ + ++ + EQ + E ++ +KI
Sbjct: 501 QEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIW 560
Query: 577 -NRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDG 635
K Q++ + + +Q EK E + + E ++ + + + + +++
Sbjct: 561 EEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEK 620
Query: 636 VLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQ 695
+ + K + K+ E+ + ++Q K+G+ ++ EQ+E + ++ + +
Sbjct: 621 IQEQEEKIREQEEKIREQEEMTQEQEE-KMGEQEEKMCEQEEKMQEQEETMWRQEEKIRE 679
Query: 696 VLKDKQEVLDQALQQNREMEGELEVIWE 723
K +E ++ +Q M+ + E +WE
Sbjct: 680 QEKKIREQEEKIREQEEMMQEQEEKMWE 707
Score = 76.3 bits (186), Expect = 1e-13
Identities = 123/573 (21%), Positives = 249/573 (43%), Gaps = 86/573 (15%)
Query: 221 SPDITGRARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEK 280
SP+ +A ++ E R + EA L L + L + A+K+L+ + + +
Sbjct: 106 SPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLIS 165
Query: 281 EKRKLKEAEK-ASSQEVAAPELLYLRKQA----QELVDENDGLKMTVHR-------LNVE 328
+L ++ K A E A + +K+A +EL E D L + ++R L +
Sbjct: 166 ---RLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEK 222
Query: 329 LSRYQTKFRHLSKEES---LNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNA 385
++ Q K + + E+S LN++ L K + LLL + + E D L
Sbjct: 223 NAKLQEKLQLVESEKSEIQLNVKELKRK----------LERAKLLLPQQQLQAEADHLG- 271
Query: 386 TLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTS-------EEWRQ-LQTQAKLVLEEN 437
+E++ ++Q V+ENE L LN+ +EW + +Q Q + + E+
Sbjct: 272 ---KELQSVSAKLQAQVEENE-LWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE 327
Query: 438 KLLLEQLEIQQRKA-----KDSHQERLQEV-----SKLTKQLMLL---EAKTHGQEKELA 484
+ + EQ E +R+ K+ R +E+ K+ +Q ++ E K QE+ +
Sbjct: 328 EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMW 387
Query: 485 ENREQLEILRAKC--------QELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEME 536
E E++ L K QE K + KI + + E ++++ ++EEK R + E
Sbjct: 388 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR---QEQEAKMWRQEEKIREQEE 444
Query: 537 ELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKI---EVLKKQVEK 593
++ E Q+K + ++ + EQ K E E + Q+ + ++KI E + +Q EK
Sbjct: 445 KIRE-------QEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEK 497
Query: 594 AMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEK 653
E + + E I ++ + + + EK + I+ + + EEK
Sbjct: 498 MHEQEEKIRKQEEKVWRQEEKIREQEEKIR-----EQEEKMWRQEEKIREQEEMWREEEK 552
Query: 654 V----KGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQ 709
+ K ++++ + D R E+ + K + +++R + ++++E + + +
Sbjct: 553 MHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEE 612
Query: 710 QNREMEGELEVIWESTFRENRRIRELLQDTLTR 742
+ RE E +++ E + +IRE Q+ +T+
Sbjct: 613 KIREQEEKIQEQEEKIREQEEKIRE--QEEMTQ 643
Score = 70.5 bits (171), Expect = 6e-12
Identities = 97/501 (19%), Positives = 224/501 (44%), Gaps = 58/501 (11%)
Query: 126 EEDIETQLSSSGKELGDVSAREDRGGHSDDLYAVPHRNQVPLL---HEVNSEDDENISHQ 182
++ ++ + GKEL VSA+ ++L+ ++ Q + E E +E I Q
Sbjct: 260 QQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQ 319
Query: 183 DGFPGSPPAPQRTQQKDGKHPVLNLKDEKPPLCEKPPPSPDITGRARQRYTEITREKFEA 242
+ R Q++ + ++ ++ + EK +R E+ EK E
Sbjct: 320 E-------EKIREQEEKIREQEEKMRRQEEMMWEKE--------EKMRRQEEMMWEKEEK 364
Query: 243 LKEENMDLNNMNQSLTLELNTM---KQAMKELQLKLKGMEK---EKRKLKEAEKASSQEV 296
++ + + + + + M ++ ++EL+ K+ EK ++ K +E EK QE
Sbjct: 365 MRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 424
Query: 297 AAPELLYLRKQAQELVDENDGLKMTVHRL--NVELSRYQTKFRHLSK----------EES 344
+ + +Q +++ ++ + ++ ++ E Q K R K EE
Sbjct: 425 RQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK 484
Query: 345 LNI--EGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVV 402
++ E K + I+ + E+ ++E++E +E+M R +E +
Sbjct: 485 IHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKM----WRQEEKI 540
Query: 403 KENEELHQE---LNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEI--QQRKAKDSHQE 457
+E EE+ +E +++ + EE RQ Q + K+ +E K+ ++ ++ Q+ K ++ ++
Sbjct: 541 REQEEMWREEEKMHEQEKIWEEEKRQEQ-EDKMWRQEEKIREQEEKVWRQEEKIREQEEK 599
Query: 458 RLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIV 517
R ++ K+ KQ E K QE+++ E E++ + QE K ++ E + +
Sbjct: 600 RQEQEEKMWKQ----EEKIREQEEKIQEQEEKI-----REQEEKIREQEEMTQEQEEKM- 649
Query: 518 NELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKIN 577
E + ++ ++EEK + + E + + ++ Q+K + ++ + EQ + ++ + E+ +
Sbjct: 650 GEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQE 709
Query: 578 RKSQKKIEVLKKQVEKAMGNE 598
K ++ E +++Q EK E
Sbjct: 710 EKMCEQEEKMQEQEEKMRRQE 730
Score = 43.1 bits (100), Expect = 0.001
Identities = 49/277 (17%), Positives = 130/277 (46%), Gaps = 29/277 (10%)
Query: 234 EITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASS 293
EI R+K E + E+ + + + + +++ ++++ + + M +++ K++E E+
Sbjct: 490 EIWRQK-EKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWR 548
Query: 294 QE--VAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLP 351
+E + E ++ ++ QE D+ + + ++ R + K R ++ E +
Sbjct: 549 EEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKM- 607
Query: 352 SKGPIPPWLLD--IKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELH 409
W + I+ + E+ ++E++E ++E+ M + + +++ ++ E++
Sbjct: 608 -------WKQEEKIREQEEKIQEQEEKIREQEE---KIREQEEMTQEQEEKMGEQEEKMC 657
Query: 410 QELNKSSAVTSEEWRQ---LQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLT 466
++ K WRQ ++ Q K + E+ + + EQ E+ Q + ++ ++ K+
Sbjct: 658 EQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQ----EQEEKMWEQEEKMC 713
Query: 467 KQLMLLEAKTHGQEKELAENREQL--EILRAKCQELK 501
+Q E K QE+++ E++ + +R + QE K
Sbjct: 714 EQ----EEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 746
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 85.1 bits (209), Expect = 2e-16
Identities = 118/525 (22%), Positives = 226/525 (43%), Gaps = 87/525 (16%)
Query: 126 EEDIETQLSSSGKELGDVSAREDRGGHSDDLYAVPHRNQVPLLHEVNSEDDENIS-HQDG 184
+ D+ET + +++ D+ +D + ++++ R+QV + + EN + HQ
Sbjct: 542 QSDMETLKADKARQIKDLEQEKDHLNRA--MWSLRERSQVSSEARMKDVEKENKALHQTV 599
Query: 185 FPGSPPAPQRTQQKDGKHPVLNLKDEKPPLCEKPPPS----PDITGRARQRYT--EITRE 238
+ Q +K H L EK EK + GR ++ T E E
Sbjct: 600 TEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATE 659
Query: 239 KFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEK------AS 292
K EAL+ E+ L N++L L+T++ + L+L+G+E++ ++L +AE
Sbjct: 660 KVEALEHESQGLQLENRTLRKSLDTLQN----VSLQLEGLERDNKQL-DAENLELRRLVE 714
Query: 293 SQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNV---ELSRYQTKFRHLSKEESLNIEG 349
+ + +L + ++ Q+L E + L+ V L + R + ++ +S E +
Sbjct: 715 TMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQS 774
Query: 350 LPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELH 409
L S L ++ E+ L L E +R+ +++ K+ + L
Sbjct: 775 LESSS---------HKTQTLESELGELEAERQALRRDL-EALRLANAQLEGAEKDRKALE 824
Query: 410 QELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQL 469
QE+ QL+ KL+ +E K L +Q+E++ DS T +L
Sbjct: 825 QEV-----------AQLEKDKKLLEKEAKRLWQQVELKDAVLDDS-----------TAKL 862
Query: 470 MLLEAKTHGQEKELAENREQLEILRAKCQEL-KTHSDGKIAVEVHKSIVNELKSQLQKEE 528
+E ++ +KELA R+ K +EL K + D V VH + L+ L E+
Sbjct: 863 SAVEKESRALDKELARCRDAA----GKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEK 918
Query: 529 EKER---AEMEELMEKLTVLQAQKKSLLLEKNS--------LTEQNKA------------ 565
K + +E+++L ++L + ++ LL E +S L +N++
Sbjct: 919 LKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEK 978
Query: 566 ---LEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLAN 607
LEA++E +NR+ + ++++LKK+ E N+ Q+L N
Sbjct: 979 IVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQ-GEGQHLQN 1022
Score = 69.7 bits (169), Expect = 1e-11
Identities = 113/549 (20%), Positives = 245/549 (44%), Gaps = 76/549 (13%)
Query: 243 LKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLK------EAEKASSQEV 296
L++EN L+ + L +L KQ+ ++L+ + + +EK +L+ +A+KA +
Sbjct: 499 LEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKADKARQIKD 558
Query: 297 AAPE-------LLYLRKQAQ--------ELVDENDGLKMTVHRLNVELSRYQTKFRHL-- 339
E + LR+++Q ++ EN L TV N +LS+ + + R L
Sbjct: 559 LEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHR 618
Query: 340 ----SKEESLNIEGL--------PSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATL 387
+KE+ E L G + + ++ + + A E + N TL
Sbjct: 619 DLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTL 678
Query: 388 KEEMRMFR---MRVQEVVKENEELHQE------LNKSSAVTSEEWRQLQTQ------AKL 432
++ + + ++++ + ++N++L E L ++ TS + Q++ + K
Sbjct: 679 RKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKE 738
Query: 433 VLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEI 492
L +N LL+ L + + + S+Q E +L + L KT E EL E + +
Sbjct: 739 ELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQA 798
Query: 493 LRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSL 552
LR + L+ + E + + + +QL+K+++ E + L +++ + A
Sbjct: 799 LRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDS 858
Query: 553 LLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLA 612
+ +++ ++++AL+ EL R R + K++ L+K + + +++ H A
Sbjct: 859 TAKLSAVEKESRALDKELARC----RDAAGKLKELEKD-NRDLTKQVTVH---------A 904
Query: 613 ENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRL 672
+T R+ L+ L K + L+K+ + ++G E + + D +++
Sbjct: 905 RTLTTLREDLV-LEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGS----DTKYKI 959
Query: 673 LEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWE--STFRENR 730
LE + + A KT +E + VL + Q +++ NR++E EL+++ + T R+N+
Sbjct: 960 LEGRNESALKTTLAMKEEK---IVLLEAQ--MEEKASLNRQLESELQMLKKECETLRQNQ 1014
Query: 731 RIRELLQDT 739
+ LQ++
Sbjct: 1015 GEGQHLQNS 1023
Score = 65.1 bits (157), Expect = 2e-10
Identities = 107/476 (22%), Positives = 191/476 (40%), Gaps = 74/476 (15%)
Query: 278 MEKEKRKLKEA---EKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQT 334
M++EK L EA EKAS EL L+K+ + L +N G E Q
Sbjct: 974 MKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETL-RQNQG----------EGQHLQN 1022
Query: 335 KFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMF 394
F+H + + + + +G + GP K + LL +D E + NA L+ E ++
Sbjct: 1023 SFKHPAGKTAASHQGKEAWGP------GHKEATMELLRVKDRAIELERNNAALQAEKQLL 1076
Query: 395 RMRVQEVVKENEELHQE---LNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKA 451
+ ++Q + +N + L K SA E LQTQ + EN L Q
Sbjct: 1077 KEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQS------- 1129
Query: 452 KDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVE 511
+ LT Q LL+ +E E + Q E L A + L ++
Sbjct: 1130 -----------AALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEAL---------LQ 1169
Query: 512 VHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKAL---EA 568
H+ L E++ AE E L+ + + L+ ++L LE L E++ + +A
Sbjct: 1170 DHE--------HLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKA 1221
Query: 569 ELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKC 628
ELE +K+ ++ ++ ++ AMG L + L + E + L K
Sbjct: 1222 ELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKE 1281
Query: 629 LESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGK-TAQYR 687
L++ + ++ + R +L+E+ + DIS L+ + +
Sbjct: 1282 LKTSLNNAQLELNRWQARFDELKEQHQTM---------DISLTKLDNHCELLSRLKGNLE 1332
Query: 688 QEMRHL---HQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDTL 740
+E HL Q+L + ++L + +N+E E + + RR +E L++ +
Sbjct: 1333 EENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKI 1388
Score = 57.0 bits (136), Expect = 7e-08
Identities = 80/359 (22%), Positives = 156/359 (43%), Gaps = 31/359 (8%)
Query: 254 NQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEA-EKASSQEVA-APELLYLRKQAQEL 311
++ T+EL +K EL+ ++ EK+ LKE + +Q V + ++L L+KQ+ L
Sbjct: 1045 HKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFL 1104
Query: 312 VDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLL 371
+ N L+ +L VE S ++ L+ + +L +K L + L
Sbjct: 1105 QEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQ--RQQEQLTA 1162
Query: 372 AYEDMMKEKDELNATLKEEMRMFRMRVQE-----VVKENEEL-HQELNKSSAVTSEEWRQ 425
AYE ++++ + L + + + +++ + N EL H+EL + + +
Sbjct: 1163 AYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAE 1222
Query: 426 LQTQAKLVLEENKLLLEQLEIQQRKAKDSHQER--LQEVSKLTKQLMLLEAKTHGQEKEL 483
L+ + K++ E + L ++ ++ + R L V+ L QL + H KEL
Sbjct: 1223 LEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKEL 1282
Query: 484 AE--NREQLEILR--AKCQELKT-HSDGKIAV---EVHKSIVNELKSQLQKEE------- 528
N QLE+ R A+ ELK H I++ + H +++ LK L++E
Sbjct: 1283 KTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQI 1342
Query: 529 ----EKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKK 583
++ + +E+ ME ++K + + N+L + LE ++ K KK
Sbjct: 1343 QLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFYDPPPKK 1401
Score = 55.1 bits (131), Expect = 3e-07
Identities = 95/423 (22%), Positives = 182/423 (43%), Gaps = 102/423 (24%)
Query: 377 MKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEE 436
+++K E + E+ + +Q+V +EN +L + +S+ +E L+ +A V
Sbjct: 270 LEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADA-RSARAYRDELDSLREKANRV--- 325
Query: 437 NKLLLEQLEIQQRKAK------DSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQL 490
E+LE++ + K D ++ R++E+ + ++L+E K A EQL
Sbjct: 326 -----ERLELELTRCKEKLHDVDFYKARMEELRE--DNIILIETK--------AMLEEQL 370
Query: 491 EILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQ---- 546
RA+ K H K +++ KS +++L +L ++ +K+R +EEL+E+ VL+
Sbjct: 371 TAARARGD--KVHELEKENLQL-KSKLHDL--ELDRDTDKKR--IEELLEENMVLEIAQK 423
Query: 547 ------------------------AQKKSLLLEKN--------SLTEQNKALEAELE--- 571
A +KS + E N L ++N++L++ ++
Sbjct: 424 QSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLR 483
Query: 572 --------------RAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQ 617
+K N + KKIE L+ Q+E+ + L+ E +
Sbjct: 484 DASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQS 543
Query: 618 ERDSLMC----LAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLL 673
+ ++L K LE EKD + N + L E+ + +A +K + ++ L
Sbjct: 544 DMETLKADKARQIKDLEQEKDHL-------NRAMWSLRERSQ-VSSEARMKDVEKENKAL 595
Query: 674 EQQEDFA-GKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRI 732
Q A GK +Q E R LH+ L+ +E ++A ++E EL+ + E R R++
Sbjct: 596 HQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERA----EKLERELQRLQEENGRLARKV 651
Query: 733 REL 735
L
Sbjct: 652 TSL 654
Score = 36.2 bits (82), Expect = 0.12
Identities = 50/265 (18%), Positives = 106/265 (40%), Gaps = 42/265 (15%)
Query: 239 KFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAA 298
++EAL ++ L ++++L LE + + ++ LK K +E+ K+ E+ + Q+
Sbjct: 1184 EYEALIRQHSCLKTLHRNLELEHKELGERHGDM-LKRKAELEEREKVLTTEREALQQEQR 1242
Query: 299 PELL--------------------YLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRH 338
L L+ + +EL LK +++ +EL+R+Q +F
Sbjct: 1243 TNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDE 1302
Query: 339 LSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRV 398
L ++ +DI L ++ + L L+EE ++
Sbjct: 1303 LKEQHQ---------------TMDIS-----LTKLDNHCELLSRLKGNLEEENHHLLSQI 1342
Query: 399 QEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQER 458
Q + ++N+ L ++ ++ EE +Q + L +K LE+ + Q K D ++
Sbjct: 1343 QLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLN-ALRRHKEKLEEKIMDQYKFYDPPPKK 1401
Query: 459 LQEVSKLTKQLMLLEAKTHGQEKEL 483
+ L++ K G + L
Sbjct: 1402 KNHWIGAKALVKLIKPKKEGSRERL 1426
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 84.7 bits (208), Expect = 3e-16
Identities = 97/530 (18%), Positives = 223/530 (42%), Gaps = 56/530 (10%)
Query: 233 TEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEA--EK 290
+E+++ K ++ ++L + Q T E KQ++ + ++ KE +LK+ ++
Sbjct: 1438 SEVSQRK----QQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKE 1493
Query: 291 ASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNV---ELSRYQTKFRHLSKEESLNI 347
+ ++ E L++ +L N T+++L V EL+R + + +S+E ++
Sbjct: 1494 TNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKD 1553
Query: 348 EGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEE 407
+ + +++ +KE ++EE+ + E + ++
Sbjct: 1554 QDITR--------------------FQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKK 1593
Query: 408 LHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTK 467
L +EL E+ ++ T LE+ ++ ++ E R+ +D L+E + +
Sbjct: 1594 LEEELEGMRRSLKEQAIKI-TNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQE 1652
Query: 468 QLMLLEAKTHGQEKELAENREQLEILRAKCQEL--------KTHSDGKIAVEVHKSIVNE 519
+L L ++ ++L + +E ++ + + ++ ++ KI +E +S+
Sbjct: 1653 ELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTEN 1712
Query: 520 L-KSQLQKEEEKE--RAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKI 576
L K L EEE R E ++L + + K + +LE S + + EL Q +
Sbjct: 1713 LTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLEL---QGL 1769
Query: 577 NRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGV 636
Q++ E L++++EK + A + + QER+SL+ K LE +K
Sbjct: 1770 INDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDK--- 1826
Query: 637 LNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQV 696
RL +LE+++ K + + RL +++ Q++ + +
Sbjct: 1827 --------ARLQRLEDELNRAKSTLEAET-RVKQRLECEKQQIQNDLNQWKTQYSRKEEA 1877
Query: 697 LKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDTLTRTGVQ 746
++ + +++ ++ + E+E + R R R L+D+ T Q
Sbjct: 1878 IRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQ 1927
Score = 81.6 bits (200), Expect = 3e-15
Identities = 118/553 (21%), Positives = 219/553 (39%), Gaps = 71/553 (12%)
Query: 231 RYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEK 290
R E E + N +++N+ E+N K +KE+ ++ + K
Sbjct: 1184 RKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKN--------- 1234
Query: 291 ASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGL 350
LR Q L EN LK + RLN + + T+ R ++E +L +
Sbjct: 1235 -------------LRNQLDRLSRENRDLKDEIVRLNDSILQ-ATEQRRRAEENALQQKAC 1280
Query: 351 PSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLK------EEMRMFRMRVQEVVKE 404
S+ L+I+ + ED + K L K +E+ + QE K
Sbjct: 1281 GSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKR 1340
Query: 405 NEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSK 464
E EL+K EE L+ Q + + K + QL +Q K +D+ R Q +
Sbjct: 1341 RWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQ--KEEDTSGYRAQ-IDN 1397
Query: 465 LTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQL 524
LT++ L + + L + E L + Q+ K + G + + + EL+
Sbjct: 1398 LTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQK--ATGSEVSQRKQQLEVELRQVT 1455
Query: 525 QKEEEKERAEMEELMEKLTVLQAQKKSL-----LLEKNSLTEQNKALEAELERAQKINRK 579
Q E+ + L + +Q + K + L++K T K LE E R Q++
Sbjct: 1456 QMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKE--TNDRKCLEDENARLQRVQYD 1513
Query: 580 SQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQER--------------DSLMCL 625
QK + + K E Q L L E ++QER L
Sbjct: 1514 LQKANSSATETINKLKVQE----QELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQ 1569
Query: 626 AKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYK---KQAALKLGDISHRLLEQQEDFAGK 682
+ +E E + + + + + KLEE+++G + K+ A+K+ +++ +L +Q K
Sbjct: 1570 KQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQL--EQASIVKK 1627
Query: 683 TAQ--YRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIREL-LQDT 739
++ RQ+ L L++KQ ++ R + E+E + +E +++ L++
Sbjct: 1628 RSEDDLRQQRDVLDGHLREKQRTQEEL----RRLSSEVEALRRQLLQEQESVKQAHLRNE 1683
Query: 740 LTRTGVQDNPRAL 752
+ ++D R+L
Sbjct: 1684 HFQKAIEDKSRSL 1696
Score = 64.7 bits (156), Expect = 3e-10
Identities = 115/573 (20%), Positives = 248/573 (43%), Gaps = 75/573 (13%)
Query: 234 EITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASS 293
E+ E+ ++ N + N N+ L L + + + KL +E+ KR+ + K++
Sbjct: 1035 EVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAK 1094
Query: 294 QEV-----AAPEL-LYLRKQAQELVDENDGLKMTVHRLNVELSRY-QTKFRHLSKEESLN 346
Q + EL + + E+ DE K R + + + Y Q + ++E+L
Sbjct: 1095 QNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLG 1154
Query: 347 IEGLPSKGPIPPWLLDIKYLSPLL-------LAYEDMM----------------KEKDEL 383
+ L S+ I +I+ L LL YE+ + K + E+
Sbjct: 1155 WQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEI 1214
Query: 384 N---ATLKE-------EMRMFRMRVQEVVKENEELHQE---LNKSSAVTSEEWRQLQTQA 430
N T+KE + + R ++ + +EN +L E LN S +E+ R+ + A
Sbjct: 1215 NITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENA 1274
Query: 431 --------KLVLEENKLLLEQLEIQQRKAKDS--HQERLQEVSKL----TKQLMLLEAKT 476
+++ ++ L +E ++ Q++++D+ H++ L+E +K K++ L+A+
Sbjct: 1275 LQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEF 1334
Query: 477 HGQEKELAENREQLEILRAKCQE--LKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAE 534
+ K E +L +R E + + + + + K+ +++L Q +++ RA+
Sbjct: 1335 QEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQ 1394
Query: 535 MEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRK-SQKK--IEVLKKQV 591
++ L + L + K L TE + +E ++++ + + SQ+K +EV +QV
Sbjct: 1395 IDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQV 1454
Query: 592 EKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIK-SNIRLGKL 650
+ E + +Y +L A+ I + + L + ++ E + K ++ N RL ++
Sbjct: 1455 TQMRTEE--SVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETND--RKCLEDENARLQRV 1510
Query: 651 EEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYR---QEMRHLHQVLKDKQEVLDQA 707
+ ++ A + ++L Q+++ Y QE Q + Q L +
Sbjct: 1511 QYDLQKANSSAT----ETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKEL 1566
Query: 708 LQQNREMEGELEVIWESTFRENRRIRELLQDTL 740
Q +++E EL + + T E+ R+ L++ L
Sbjct: 1567 QLQKQKVEEELNRL-KRTASEDSCKRKKLEEEL 1598
Score = 44.3 bits (103), Expect = 4e-04
Identities = 103/534 (19%), Positives = 211/534 (39%), Gaps = 97/534 (18%)
Query: 247 NMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPELLYLRK 306
++DL + +T + ++ K++ +L +EK+ +K+ A + LY K
Sbjct: 850 DLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQ---IKQLRNYRDNYQAFCKWLYDAK 906
Query: 307 QAQELVDE-NDGLKMTVHR-------LNVELSRYQTKFRHLSKEESL------------- 345
+ Q+ ++ G TV R L+ E+S + K + K L
Sbjct: 907 RRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLA 966
Query: 346 -------NIEGLPSK--------GPIPPWLLDI---------------KYLSPLLLAYED 375
+ +P K G I D+ ++LS +L + ED
Sbjct: 967 SYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLED 1026
Query: 376 MMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLV-L 434
+K K+ L+EE+R+ R E +N+ L Q L K A S Q +AKL L
Sbjct: 1027 -LKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECS------QFKAKLASL 1079
Query: 435 EENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILR 494
EE L Q E+ + AK + + ++ +L +++ L + +++ ++ +
Sbjct: 1080 EE---LKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFD--- 1133
Query: 495 AKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEE----LMEKLTVLQAQKK 550
Q+ + + A + K + K + +K +++ E+E L E+ T + +
Sbjct: 1134 ---QQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYEN 1190
Query: 551 SLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVG 610
L +N E+ L + E I + + K+I + K+ K + N++ +
Sbjct: 1191 ELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLD--RLSRENRD 1248
Query: 611 LAENITQERDS-LMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDIS 669
L + I + DS L + +E++ + K S I K ++ ++
Sbjct: 1249 LKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEI------------ELK 1296
Query: 670 HRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWE 723
+ ++ ED A+++Q + + ++DK + +++ E + E + WE
Sbjct: 1297 QVMQQRSED----NARHKQSLEEAAKTIQDKNKEIERL---KAEFQEEAKRRWE 1343
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 84.3 bits (207), Expect = 4e-16
Identities = 124/599 (20%), Positives = 252/599 (42%), Gaps = 94/599 (15%)
Query: 217 KPPPSPDITGRARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLK 276
KP + R Q+ E+ + K L +N L + + L+ +K+ L +++K
Sbjct: 670 KPEEHEQVKSRLEQKSGELGK-KITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMK 728
Query: 277 GME---KEKRKLKEAEKASSQEVAAPELLYLRK------QAQELVDENDGLKMTVHRLN- 326
K +K++ A ++ L +K + ++L+ END L V RL
Sbjct: 729 NHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLET 788
Query: 327 -------------------VELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLS 367
VEL + ++ + E+ I L S+ ++ +Y+
Sbjct: 789 VFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVP 848
Query: 368 PLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNK---SSAVTSEEWR 424
+K +E+ TL + + + +V K+ E+++QE K + +
Sbjct: 849 ---------VKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLE 899
Query: 425 QLQTQAK---LVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEK 481
Q Q K + L E++ + L RK +DS+ E L K ++++ L A+ Q+K
Sbjct: 900 NTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKK 959
Query: 482 ELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQK------EEEKERAEM 535
EL +E +++ A + A E K + ++L Q QK E +K + E
Sbjct: 960 ELDTIQECIKVKYAPIVSFEECERKFKATE--KELKDQLSEQTQKYSVSEEEVKKNKQEN 1017
Query: 536 EELMEKLTVLQ--AQKKSLLLEKN---------SLTEQNKALEAELERAQKINRKSQKKI 584
++L +++ LQ + K++L+EK+ E NK L+ ++ ++ +K +
Sbjct: 1018 DKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLV 1077
Query: 585 EVLKKQVEKAMG-NEMSAHQYL---------ANLVGLAENITQERDSLMCLAKCLESEKD 634
E KQ + + + Q++ +L G EN+ +E L + +C E E+
Sbjct: 1078 EENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEE---LKSMQRCYEKEQQ 1134
Query: 635 GV------LNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGK---TAQ 685
V L S++ L + + + ++K+ +G I L E++E+ K ++
Sbjct: 1135 TVTKLHQLLENQKNSSVPLAEHLQIKEAFEKE----VGIIKASLREKEEESQNKMEEVSK 1190
Query: 686 YRQEMRHLHQVLK--DKQEVLDQALQQ--NREMEGELEVIWESTFRENRRIRELLQDTL 740
+ E+++ Q LK + +EV+D + + ++E ++ + E NR+ E+ ++ L
Sbjct: 1191 LQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVL 1249
Score = 54.3 bits (129), Expect = 4e-07
Identities = 109/544 (20%), Positives = 227/544 (41%), Gaps = 70/544 (12%)
Query: 226 GRARQRYTEITREKFEALKEE-NMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRK 284
G+ +Q T F ALKE + + N LT EL K +K+L++K +G E K
Sbjct: 498 GKVKQMQTH-----FLALKEHLTSEAASGNHRLTEEL---KDQLKDLKVKYEGASAEVGK 549
Query: 285 LKEAEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVE-------LSRYQTKFR 337
L+ K + V ++ +L++EN L+ + +E ++ + + +
Sbjct: 550 LRNQIKQNEMIVEE-----FKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAK 604
Query: 338 HLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMR 397
LS + +L+I + ++ + L+ E ++ LK E+ + +
Sbjct: 605 ELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAK 664
Query: 398 VQEVVK--ENEELHQELNKSSAVTSEEWRQ-------LQTQAKLVLEENKLLLEQ---LE 445
+ + VK E+E++ L + S ++ + LQ + + V +NKLL EQ L
Sbjct: 665 LAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLT 724
Query: 446 IQQRK----------AKDSHQERLQEVS-KLTKQLMLLEAKTHGQEKELAEN---REQLE 491
I+ + K SH + +++ KL K EK L EN + +
Sbjct: 725 IEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVS 784
Query: 492 ILRAKCQELKTHSDGKIAVEVH----KSIVNELKSQLQKEEEK------ERAEMEELMEK 541
L + H IA++ + K ++ELK + +++EK E ++++M
Sbjct: 785 RLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSN 844
Query: 542 LTV-LQAQKKSLLLEKNSLTEQNKALEAELERAQKINR---KSQKKIEVLKKQVEKAMGN 597
V ++ ++ + ++L + N+ L ++ + IN+ K + K E+LK+ +E
Sbjct: 845 QYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLEN---- 900
Query: 598 EMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGY 657
+ +Q A + LAE+ + + K +S + +L K + L ++K
Sbjct: 901 --TQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAE-ILANYRKGQEEIVTLHAEIKAQ 957
Query: 658 KKQ--AALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREME 715
KK+ + + + + E+ K +E++ K V ++ +++N++
Sbjct: 958 KKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQEN 1017
Query: 716 GELE 719
+L+
Sbjct: 1018 DKLK 1021
Score = 50.8 bits (120), Expect = 5e-06
Identities = 114/608 (18%), Positives = 233/608 (38%), Gaps = 114/608 (18%)
Query: 199 DGKHP-VLNLKDEKPPLCEKP-PPSPDITGRARQRYTEIT-------REKFEALKEENMD 249
DG+ P VL + +P +C+ D+ R +Q T + R+ E L + D
Sbjct: 153 DGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGAD 212
Query: 250 LNNMN----------------QSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASS 293
++ ++ LTL + K +L KG ++R L +
Sbjct: 213 ISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELWKKGPSLQQRNLTHMQ---- 268
Query: 294 QEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLS---KEESLNIEGL 350
EV + Q+L EN+ LK + ++ E K L EE + + L
Sbjct: 269 DEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDL 328
Query: 351 PSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRM-----------RVQ 399
S+ + L LL A E +E LK + F R +
Sbjct: 329 ESER---------EKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKE 379
Query: 400 EVVKENEELHQELNKSSAVTSEEWRQ---------LQTQAKLVLEENKLLLEQLEIQQRK 450
+++ + +++ ++ ++ Q L ++ EN++L ++LE +
Sbjct: 380 DMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTF 439
Query: 451 AKDSHQERLQEVSKLT---------------------KQLMLLEAKTHGQEKELAENREQ 489
+ + Q+RL+ ++L +Q+ LE +K + E+ +
Sbjct: 440 CESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGK 499
Query: 490 LEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQK---EEEKERAEMEELMEKLTVLQ 546
++ ++ LK H + A H+ + ELK QL+ + E AE+ +L ++ +
Sbjct: 500 VKQMQTHFLALKEHLTSEAASGNHR-LTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNE 558
Query: 547 AQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLA 606
+ ++ L E+NK L+ EL + K +K+ ++ Q + E+SA
Sbjct: 559 MIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAK-----ELSAK---- 609
Query: 607 NLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLG 666
LA +I E+ M +S +N+ K + + + EK +Q +L
Sbjct: 610 ----LALSIPAEKFENM------KSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELE 659
Query: 667 DISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTF 726
++ +L + K ++ Q L Q + + + + +N+ ++ E+E + +
Sbjct: 660 NVKAKLAQHV-----KPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKV----Y 710
Query: 727 RENRRIRE 734
+N+ ++E
Sbjct: 711 LDNKLLKE 718
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 84.3 bits (207), Expect = 4e-16
Identities = 124/599 (20%), Positives = 252/599 (42%), Gaps = 94/599 (15%)
Query: 217 KPPPSPDITGRARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLK 276
KP + R Q+ E+ + K L +N L + + L+ +K+ L +++K
Sbjct: 683 KPEEHEQVKSRLEQKSGELGK-KITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMK 741
Query: 277 GME---KEKRKLKEAEKASSQEVAAPELLYLRK------QAQELVDENDGLKMTVHRLN- 326
K +K++ A ++ L +K + ++L+ END L V RL
Sbjct: 742 NHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLET 801
Query: 327 -------------------VELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLS 367
VEL + ++ + E+ I L S+ ++ +Y+
Sbjct: 802 VFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVP 861
Query: 368 PLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNK---SSAVTSEEWR 424
+K +E+ TL + + + +V K+ E+++QE K + +
Sbjct: 862 ---------VKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLE 912
Query: 425 QLQTQAK---LVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEK 481
Q Q K + L E++ + L RK +DS+ E L K ++++ L A+ Q+K
Sbjct: 913 NTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKK 972
Query: 482 ELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQK------EEEKERAEM 535
EL +E +++ A + A E K + ++L Q QK E +K + E
Sbjct: 973 ELDTIQECIKVKYAPIVSFEECERKFKATE--KELKDQLSEQTQKYSVSEEEVKKNKQEN 1030
Query: 536 EELMEKLTVLQ--AQKKSLLLEKN---------SLTEQNKALEAELERAQKINRKSQKKI 584
++L +++ LQ + K++L+EK+ E NK L+ ++ ++ +K +
Sbjct: 1031 DKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLV 1090
Query: 585 EVLKKQVEKAMG-NEMSAHQYL---------ANLVGLAENITQERDSLMCLAKCLESEKD 634
E KQ + + + Q++ +L G EN+ +E L + +C E E+
Sbjct: 1091 EENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEE---LKSMQRCYEKEQQ 1147
Query: 635 GV------LNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGK---TAQ 685
V L S++ L + + + ++K+ +G I L E++E+ K ++
Sbjct: 1148 TVTKLHQLLENQKNSSVPLAEHLQIKEAFEKE----VGIIKASLREKEEESQNKMEEVSK 1203
Query: 686 YRQEMRHLHQVLK--DKQEVLDQALQQ--NREMEGELEVIWESTFRENRRIRELLQDTL 740
+ E+++ Q LK + +EV+D + + ++E ++ + E NR+ E+ ++ L
Sbjct: 1204 LQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVL 1262
Score = 54.3 bits (129), Expect = 4e-07
Identities = 109/544 (20%), Positives = 227/544 (41%), Gaps = 70/544 (12%)
Query: 226 GRARQRYTEITREKFEALKEE-NMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRK 284
G+ +Q T F ALKE + + N LT EL K +K+L++K +G E K
Sbjct: 511 GKVKQMQTH-----FLALKEHLTSEAASGNHRLTEEL---KDQLKDLKVKYEGASAEVGK 562
Query: 285 LKEAEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVE-------LSRYQTKFR 337
L+ K + V ++ +L++EN L+ + +E ++ + + +
Sbjct: 563 LRNQIKQNEMIVEE-----FKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAK 617
Query: 338 HLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMR 397
LS + +L+I + ++ + L+ E ++ LK E+ + +
Sbjct: 618 ELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAK 677
Query: 398 VQEVVK--ENEELHQELNKSSAVTSEEWRQ-------LQTQAKLVLEENKLLLEQ---LE 445
+ + VK E+E++ L + S ++ + LQ + + V +NKLL EQ L
Sbjct: 678 LAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLT 737
Query: 446 IQQRK----------AKDSHQERLQEVS-KLTKQLMLLEAKTHGQEKELAEN---REQLE 491
I+ + K SH + +++ KL K EK L EN + +
Sbjct: 738 IEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVS 797
Query: 492 ILRAKCQELKTHSDGKIAVEVH----KSIVNELKSQLQKEEEK------ERAEMEELMEK 541
L + H IA++ + K ++ELK + +++EK E ++++M
Sbjct: 798 RLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSN 857
Query: 542 LTV-LQAQKKSLLLEKNSLTEQNKALEAELERAQKINR---KSQKKIEVLKKQVEKAMGN 597
V ++ ++ + ++L + N+ L ++ + IN+ K + K E+LK+ +E
Sbjct: 858 QYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLEN---- 913
Query: 598 EMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGY 657
+ +Q A + LAE+ + + K +S + +L K + L ++K
Sbjct: 914 --TQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAE-ILANYRKGQEEIVTLHAEIKAQ 970
Query: 658 KKQ--AALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREME 715
KK+ + + + + E+ K +E++ K V ++ +++N++
Sbjct: 971 KKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQEN 1030
Query: 716 GELE 719
+L+
Sbjct: 1031 DKLK 1034
Score = 50.8 bits (120), Expect = 5e-06
Identities = 114/608 (18%), Positives = 233/608 (38%), Gaps = 114/608 (18%)
Query: 199 DGKHP-VLNLKDEKPPLCEKP-PPSPDITGRARQRYTEIT-------REKFEALKEENMD 249
DG+ P VL + +P +C+ D+ R +Q T + R+ E L + D
Sbjct: 166 DGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGAD 225
Query: 250 LNNMN----------------QSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASS 293
++ ++ LTL + K +L KG ++R L +
Sbjct: 226 ISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELWKKGPSLQQRNLTHMQ---- 281
Query: 294 QEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLS---KEESLNIEGL 350
EV + Q+L EN+ LK + ++ E K L EE + + L
Sbjct: 282 DEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDL 341
Query: 351 PSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRM-----------RVQ 399
S+ + L LL A E +E LK + F R +
Sbjct: 342 ESER---------EKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKE 392
Query: 400 EVVKENEELHQELNKSSAVTSEEWRQ---------LQTQAKLVLEENKLLLEQLEIQQRK 450
+++ + +++ ++ ++ Q L ++ EN++L ++LE +
Sbjct: 393 DMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTF 452
Query: 451 AKDSHQERLQEVSKLT---------------------KQLMLLEAKTHGQEKELAENREQ 489
+ + Q+RL+ ++L +Q+ LE +K + E+ +
Sbjct: 453 CESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGK 512
Query: 490 LEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQK---EEEKERAEMEELMEKLTVLQ 546
++ ++ LK H + A H+ + ELK QL+ + E AE+ +L ++ +
Sbjct: 513 VKQMQTHFLALKEHLTSEAASGNHR-LTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNE 571
Query: 547 AQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLA 606
+ ++ L E+NK L+ EL + K +K+ ++ Q + E+SA
Sbjct: 572 MIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAK-----ELSAK---- 622
Query: 607 NLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLG 666
LA +I E+ M +S +N+ K + + + EK +Q +L
Sbjct: 623 ----LALSIPAEKFENM------KSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELE 672
Query: 667 DISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTF 726
++ +L + K ++ Q L Q + + + + +N+ ++ E+E + +
Sbjct: 673 NVKAKLAQHV-----KPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKV----Y 723
Query: 727 RENRRIRE 734
+N+ ++E
Sbjct: 724 LDNKLLKE 731
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 84.0 bits (206), Expect = 5e-16
Identities = 105/478 (21%), Positives = 208/478 (43%), Gaps = 42/478 (8%)
Query: 260 ELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASS-QEVAAPELLYLRKQAQELVDENDGL 318
+L ++ +E + + EKE+R+ + E+ Q + E L R++AQ+L +E DGL
Sbjct: 797 QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGL 856
Query: 319 KMTVHRLNVELSRYQTKFR-HLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMM 377
+ R + R K+R L +E L +K P ++ LL E+ +
Sbjct: 857 QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK---PALQEQLRKEQQLLQEEEEEL 913
Query: 378 KEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEEN 437
+ ++ +E+ R +R Q +E + L +E K E RQ + KL +E
Sbjct: 914 QREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRR--RQERERQYRKDKKLQQKEE 971
Query: 438 KLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKC 497
+LL E+ E ++R+ ++ +E+ + +QL+ +E+ R++ E K
Sbjct: 972 QLLGEEPEKRRRQEREKKYREEEELQQEEEQLL--------REEREKRRRQEWERQYRKK 1023
Query: 498 QELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQ--KKSLLLE 555
EL+ + + E K + E + Q ++EEE ++ E + L E+ + Q ++ E
Sbjct: 1024 DELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKE 1083
Query: 556 KNSLTEQNKALEAELERAQKINRKSQ-KKIEVLKKQVEKAMGNEMS--AHQYLANLVGLA 612
+ E+ + L E E+ ++ R+ Q ++ E L+++ E+ + E Q L
Sbjct: 1084 EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREE 1143
Query: 613 ENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRL 672
E + QE + L ++ + +E + Y+++ L+ +
Sbjct: 1144 EEVQQEEEQL------------------LREEPEKRRRQELERQYREEEELQQEEEQLLR 1185
Query: 673 LEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENR 730
EQ++ + QYR+E Q K KQ D+ Q +++ + E E+ R+N+
Sbjct: 1186 EEQEKRRQERERQYREEEELQRQ--KRKQRYRDE--DQRSDLKWQWEPEKENAVRDNK 1239
Score = 69.7 bits (169), Expect = 1e-11
Identities = 131/706 (18%), Positives = 276/706 (39%), Gaps = 96/706 (13%)
Query: 100 RPRPNWQSEMGRRS------SLPSFETLDYGDEEDIETQLSSSGKELGDVSAREDRGGHS 153
R R WQ RR+ S ET ++ DEE + + + G ++ R
Sbjct: 175 RQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQ 234
Query: 154 DDLYAVPHRNQVPLLHEVNSEDDENISHQDGFPGSPPAPQRTQQKDGKHPVLNLKDEKPP 213
D ++ + V +++E + ++ P + Q+++ + L ++ +
Sbjct: 235 DRVFQEEEEKEWRKRETVLRKEEEKLQEEE-----PQRQRELQEEEEQLRKLERQELRRE 289
Query: 214 LCEKPPPSPDITG--RARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKEL 271
E+ + + R++ E RE+ E +E+ + +L ++ +E
Sbjct: 290 RQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQ 349
Query: 272 QLKLKGMEKEKR----KLKEAEKASSQEVAAPELLYLRKQA---------------QELV 312
QL+ + E+E+R + ++ E+ Q++ + L +Q Q+L
Sbjct: 350 QLR-REQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 408
Query: 313 DENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIP--PWLLDIKYLSPLL 370
E + R +L R Q + RH K E E + WL +
Sbjct: 409 REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETER-- 466
Query: 371 LAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQA 430
+ + K +L +EE R ++++E +E E + + EE R+ + +
Sbjct: 467 ---HEQERRKQQLKRDQEEERRERWLKLEE--EERREQQERREQQLRREQEERREQRLKR 521
Query: 431 KLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQL 490
+ EE + L ++L +Q+ ++ + R Q + + ++ + E + ++E E R+QL
Sbjct: 522 Q---EEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL 578
Query: 491 --EILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQ 548
+ Q LK + ++ + + V L+ + ++E+ +R E EE +
Sbjct: 579 LKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEE----------E 628
Query: 549 KKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANL 608
++ LL+ EQ + + +L R Q+ R+ + K E ++++E+ + E + L
Sbjct: 629 RRQQLLKSE---EQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQEL 685
Query: 609 VGLAENITQER--DSLMCLAKCLESEKDGVLNKVI------KSNIRLGKLEEKVKGYKKQ 660
+ +ER + LESE D +KV + R + EEK + + +
Sbjct: 686 AEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESE 745
Query: 661 AALKLGDISHRLLEQQEDFAGKTAQYR----------------------------QEMRH 692
+ + +HR +++E T Q++ +E +
Sbjct: 746 LQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQ 805
Query: 693 LHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQD 738
Q ++E +Q +Q RE E EL+ + E + R + LQ+
Sbjct: 806 REQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE 851
Score = 63.5 bits (153), Expect = 7e-10
Identities = 84/395 (21%), Positives = 174/395 (44%), Gaps = 36/395 (9%)
Query: 227 RARQRYTEITRE--KFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKR- 283
R +QR + R+ + E L++E + Q + +Q ++ + + K ME E++
Sbjct: 1545 RGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQL 1604
Query: 284 KLKEAEKASSQE----VAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRH- 338
+ +E ++ QE E L ++ Q+L + K + + + RH
Sbjct: 1605 RRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHD 1664
Query: 339 ----LSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMF 394
+EE L EG + + D K+ E ++ ++ L+EE ++
Sbjct: 1665 RDRKFREEEQLLQEG--EEQQLRRQERDRKFREE-----EQQLRRQERERKFLQEEQQLR 1717
Query: 395 RMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDS 454
R ++ +E E+L QE + E +R++ + +L E + +QL Q+R K
Sbjct: 1718 RQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREE---QQLRRQERDRKFR 1774
Query: 455 HQERLQEVSKLTKQLMLLEA-KTHGQEKELAENREQLEILRAKCQELKTHS-DGKIAVEV 512
+E+L++ + +QL E+ + +E++L + RE+ Q+L+ DGK E
Sbjct: 1775 EEEQLRQ-EREEQQLRSQESDRKFREEEQLRQEREE--------QQLRPQQRDGKYRWEE 1825
Query: 513 HKSIVNELKSQLQKEEEKE-RAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELE 571
+ + E + +L++E +++ RAE + ++ + + Q+ E+ E+ + L E
Sbjct: 1826 EQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHI 1885
Query: 572 RAQKINRKSQKKIEVLKKQVEKAMGN--EMSAHQY 604
R Q+ + +++ +K Q K G E HQ+
Sbjct: 1886 RRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQF 1920
Score = 60.5 bits (145), Expect = 6e-09
Identities = 92/481 (19%), Positives = 208/481 (43%), Gaps = 50/481 (10%)
Query: 265 KQAMKELQLKLKGMEKEK-RKLKEAEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVH 323
+ A+++ ++ KG E E+ R+L++++ Q + +L +L + QE E
Sbjct: 1232 ENAVRDNKVYCKGRENEQFRQLEDSQLRDRQ--SQQDLQHLLGEQQERDREQ-------- 1281
Query: 324 RLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDEL 383
E R+Q + RH +EE L E + K L L + + + E
Sbjct: 1282 ----ERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQL---LREEREEKRRRQET 1334
Query: 384 NATLKEEMRMFRMRVQEVVK---------ENEELHQELNKSSAVTSEEWRQLQTQAKLVL 434
+ +EE ++ + R ++ ++ E E HQE + + R+ + + K +
Sbjct: 1335 DRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLK 1394
Query: 435 EENKLLLEQLEIQQRKAKD-SHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEIL 493
EE +L ++ E Q R+ +D +E Q++S+ + + K +E+++ + + L
Sbjct: 1395 EEQQLRCQEREQQLRQDRDRKFREEEQQLSRQER-----DRKFREEEQQVRRQERERKFL 1449
Query: 494 RAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLL 553
+ Q+L+ K E + ++ E + Q +E++R +EE + L+ Q++
Sbjct: 1450 EEE-QQLRQERHRKFREE--EQLLQEREEQQLHRQERDRKFLEEEQQ----LRRQERDRK 1502
Query: 554 LEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAE 613
+ L Q + LE Q+++R+ +++ + ++Q + Q E
Sbjct: 1503 FREQELRSQEPERKF-LEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEE 1561
Query: 614 NITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLL 673
+ QER+ + E+D K ++ + E++ K + + L+ + +L
Sbjct: 1562 QLRQEREE----QQLSRQERD---RKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLR 1614
Query: 674 EQQEDFAGKTAQYRQEM--RHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRR 731
++++ + Q QE + LH+ +D++ + ++ + +E E +L + FRE +
Sbjct: 1615 QERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQ 1674
Query: 732 I 732
+
Sbjct: 1675 L 1675
Score = 60.5 bits (145), Expect = 6e-09
Identities = 118/567 (20%), Positives = 231/567 (40%), Gaps = 78/567 (13%)
Query: 193 QRTQQKDGKHPVLNLKDEKPPLCEKPPPSPDITGRARQRYTEITREKFEALKE-ENMDLN 251
+R +QK+ K ++EK L E+ R RQ RE+ + L+E E L
Sbjct: 1300 EREEQKEAKRRDRKSQEEKQLLREEREEK-----RRRQETDRKFREEEQLLQEREEQPLR 1354
Query: 252 NMNQSLTL---ELNTMKQAMK--ELQLKLKGMEKEKRKLKEAEKASSQE----VAAPELL 302
+ EL +Q K E + +L+ E+E++ LKE ++ QE +
Sbjct: 1355 RQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDR 1414
Query: 303 YLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLD 362
R++ Q+L + K V + KF L +E+ L E
Sbjct: 1415 KFREEEQQLSRQERDRKFREEEQQVRRQERERKF--LEEEQQLRQERHRK---------- 1462
Query: 363 IKYLSPLLLAYEDMMKEKDELNAT-LKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSE 421
+ LL E+ + E + L+EE ++ R +E E QE + +
Sbjct: 1463 FREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQ 1522
Query: 422 EWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDS---HQERLQ---EVSKLTKQ-----LM 470
+ + Q Q K + EE +L ++ Q+R+ +D +E+L+ E +L++Q
Sbjct: 1523 QLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFR 1582
Query: 471 LLEAKTHGQEKE--LAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEE 528
L E K QE+E E+ +QL + Q+L+ D K + + ++ E + Q +
Sbjct: 1583 LEEQKVRRQEQERKFMEDEQQLRRQEGQ-QQLRQERDRKFRED--EQLLQEREEQQLHRQ 1639
Query: 529 EKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLK 588
E++R +EE E Q +++ L +++ + + L E E Q ++ +K +
Sbjct: 1640 ERDRKFLEE--EPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE 1697
Query: 589 KQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLG 648
+Q+ + QER+ K L+ E+ + + ++ R
Sbjct: 1698 QQLRR-----------------------QERER-----KFLQEEQQ-LRRQELERKFRE- 1727
Query: 649 KLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQAL 708
EE+++ +Q L+ + ++LE+++ + Q + + +++Q ++
Sbjct: 1728 --EEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREE 1785
Query: 709 QQNREMEGELEVIWESTFRENRRIREL 735
QQ R E + + E R+ R ++L
Sbjct: 1786 QQLRSQESDRKFREEEQLRQEREEQQL 1812
Score = 60.1 bits (144), Expect = 8e-09
Identities = 125/592 (21%), Positives = 242/592 (40%), Gaps = 92/592 (15%)
Query: 227 RARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLK-----GMEKE 281
R RQ RE+ E L++E L + +Q K+ +L+ K G E E
Sbjct: 921 RRRQEQERQYREE-EQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPE 979
Query: 282 KRKLKEAEKA--SSQEVAAPELLYLRKQAQEL-----------VDENDGLKMTVHRLNVE 328
KR+ +E EK +E+ E LR++ ++ DE + + R E
Sbjct: 980 KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREERE 1039
Query: 329 LSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAY---EDMMKEKDELNA 385
R Q + R +EE L E G + + L Y E++ +E+++L
Sbjct: 1040 KRRLQERERQYREEEELQQEEEQLLGEER----ETRRRQELERQYRKEEELQQEEEQL-- 1093
Query: 386 TLKEEMRMFRMRVQE-VVKENEELHQELN------KSSAVTSEEWRQLQTQAKLVLEENK 438
L+EE R + +E +E EEL QE + E RQ + + ++ EE +
Sbjct: 1094 -LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQ 1152
Query: 439 LLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQ 498
LL E+ E ++R+ + +E+ + +QL+ E + QE+E + RE+ E+ R K +
Sbjct: 1153 LLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERE-RQYREEEELQRQKRK 1211
Query: 499 ELKTHSDGKIAVEVH----------------KSIVNELKSQLQKEEEKERAEMEELMEKL 542
+ D + ++ K NE QL+ + ++R ++L L
Sbjct: 1212 QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLL 1271
Query: 543 TVLQAQKKSLLLEKNSLTEQNKALEAELER-----AQKINRKSQKKIEVLKKQVEKAMGN 597
Q + + + +++ E +LER A++ +RKSQ++ ++L+++ E+
Sbjct: 1272 GEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRR 1331
Query: 598 EMSAHQYLANLVGLAENITQ-----ERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEE 652
+ + ++ L E Q ERD + E+ K ++ RL + E
Sbjct: 1332 QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQG---RKFLEEEQRLRRQER 1388
Query: 653 KVKGYKKQAALKLGDISHRLL----------EQQEDFAGKTAQYRQEMRHLHQ------V 696
+ K K++ L+ + +L EQQ + ++R+E + + +
Sbjct: 1389 ERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKF 1448
Query: 697 LKDKQEVL----------DQALQQNREMEGELEVIWESTFRENRRIRELLQD 738
L+++Q++ +Q LQ+ E + + E +++R +D
Sbjct: 1449 LEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERD 1500
Score = 58.9 bits (141), Expect = 2e-08
Identities = 115/585 (19%), Positives = 248/585 (42%), Gaps = 63/585 (10%)
Query: 174 EDDENISHQDGFPGSPPAPQRTQQKDGKHPVLNLKDEKPPLCEKPPPSPDITGRARQRYT 233
ED +D P +R Q++ + L +E+ E+ + R RQR
Sbjct: 117 EDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQER------LEQRDRQRRD 170
Query: 234 EIT---REKFEALKE---ENMDLNNMNQSLTLELNTMKQAMKE--LQLKLKGMEKEKRKL 285
E R++++ +E E L + T E +Q + L+L+ KG E+++++
Sbjct: 171 EELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQR 230
Query: 286 KEAEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESL 345
+E + QE E RK+ L E + L+ + EL + + R L ++E L
Sbjct: 231 RERQDRVFQEEEEKEW---RKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQE-L 286
Query: 346 NIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKEN 405
E + L E ++ K E ++E R + +E +E
Sbjct: 287 RRERQEEEQ------------QQQRLRREQQLRRKQEEERREQQEERREQQERREQQEER 334
Query: 406 EELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKL 465
E Q+L + E+ QL+ + + E +L EQ E ++R+ + +++L+ +L
Sbjct: 335 RE--QQLRREQEERREQ--QLRREQEEERREQQLRREQEE-ERREQQLRREQQLRREQQL 389
Query: 466 TKQLMLLEAKTHGQEKELAENRE-QLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQL 524
++ L + +E++L ++ + E + Q+L+ + + + H+ E + +
Sbjct: 390 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKR 449
Query: 525 QKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKI 584
++EE ++ + EE E+ + +++ ++ E+ LE E R Q+ R+ Q +
Sbjct: 450 EQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRR 509
Query: 585 EVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSN 644
E +++ ++ E E + Q S L + E ++ +L + +
Sbjct: 510 EQEERREQRLKRQEEE------------ERLQQRLRSEQQLRREQEERREQLLKREEEKR 557
Query: 645 IRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLK------ 698
+ + E+++K +++ +LL+++E+ + + QE R L Q LK
Sbjct: 558 LEQERREQRLKREQEER-------RDQLLKREEERRQQRLKREQEER-LEQRLKREEVER 609
Query: 699 -DKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDTLTR 742
+++E +Q L++ E + + +S +E RR ++L ++ R
Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQER 654
Score = 52.8 bits (125), Expect = 1e-06
Identities = 73/363 (20%), Positives = 159/363 (43%), Gaps = 44/363 (12%)
Query: 388 KEEMRMFRMRVQEVVKE-NEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQL-- 444
+E+ R F R +++ +E + Q+ + +E Q + Q +L + + E+L
Sbjct: 116 EEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWR 175
Query: 445 ---EIQQRKAKDSHQERLQEVS----------KLTKQLMLLEAKTHGQEKELAENREQLE 491
E Q+R+ + + +E+LQ + ++ LLE + G+E++ + RE+ +
Sbjct: 176 QRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQD 235
Query: 492 ILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKS 551
+ + +E + ++++ + + +LQ+EE + + E++E E+L L+ Q+
Sbjct: 236 RVFQEEEEKEWRK--------RETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELR 287
Query: 552 LLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGL 611
++ +Q E +L R Q+ R+ Q+ E ++Q E+ E Q L
Sbjct: 288 RERQEEEQQQQRLRREQQLRRKQEEERREQQ--EERREQQERREQQEERREQQL------ 339
Query: 612 AENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHR 671
+ER + E ++ L + + R +L + + ++Q +
Sbjct: 340 -RREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQ----------Q 388
Query: 672 LLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRR 731
L +Q+ + + Q++R Q+ +++Q +Q L++ +E E E E RE R
Sbjct: 389 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERH-EQKHEQERREQRL 447
Query: 732 IRE 734
RE
Sbjct: 448 KRE 450
Score = 51.6 bits (122), Expect = 3e-06
Identities = 113/561 (20%), Positives = 234/561 (41%), Gaps = 78/561 (13%)
Query: 227 RARQRYTEITRE-KFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKR-- 283
R Q++ + RE + + +EE D + E +Q ++ QLK + E+E+R
Sbjct: 433 RHEQKHEQERREQRLKREQEERRDWLKREE----ETERHEQERRKQQLK-RDQEEERRER 487
Query: 284 --KLKEAEKASSQEVAAPELLY----LRKQAQELVDENDGLKMTVHRLNVELSRYQTKFR 337
KL+E E+ QE +L R+Q + +E + L+ + R +L R Q + R
Sbjct: 488 WLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRL-RSEQQLRREQEERR 546
Query: 338 H--LSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFR 395
L +EE +E + + + + + ++K ++E + + R
Sbjct: 547 EQLLKREEEKRLEQERREQRLKREQEERR---------DQLLKREEERRQQRLKREQEER 597
Query: 396 MRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENK-LLLEQLEIQQRKAKDS 454
+ + +E E L QE + + EE + + Q L EE + +QL +Q++ ++
Sbjct: 598 LEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ 657
Query: 455 HQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQ------ELKTHSDGKI 508
+R +E +L ++L E + +E+ELAE ++ R K + +L++ +D +
Sbjct: 658 RLKREEEEERLEQRLKR-EHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQ 716
Query: 509 AVEVHKSIVNELKSQLQKEEEKERAEMEELM---EKLTVLQAQKKSLLLEKNSLTEQNKA 565
+ + E + + Q++EEK R EL E+ Q Q++ ++ T Q +A
Sbjct: 717 SKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEE---QRRDFTWQWQA 773
Query: 566 ----------------LEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLV 609
L + ER + + Q++ L ++ EK +
Sbjct: 774 EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQF 833
Query: 610 GLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKG------------- 656
E Q R+ A+ L+ E+DG+ + + + ++K +
Sbjct: 834 LEEEEQLQRRER----AQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTL 889
Query: 657 YKKQAALKLGDISHRLLEQQED---FAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNRE 713
Y K A + +LL+++E+ + + RQE ++ + Q+ +Q L++ RE
Sbjct: 890 YAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREERE 949
Query: 714 MEGELEVIWESTFRENRRIRE 734
E E +R+++++++
Sbjct: 950 KRRRQE--RERQYRKDKKLQQ 968
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 83.6 bits (205), Expect = 7e-16
Identities = 116/556 (20%), Positives = 244/556 (43%), Gaps = 61/556 (10%)
Query: 221 SPDITGRARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEK 280
SP+ +A ++ E R + EA L L + L + A+K+L+ + + +
Sbjct: 106 SPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLIS 165
Query: 281 EKRKLKEAEK-ASSQEVAAPELLYLRKQA----QELVDENDGLKMTVHR-------LNVE 328
+L ++ K A E A + +K+A +EL E D L + ++R L +
Sbjct: 166 ---RLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEK 222
Query: 329 LSRYQTKFRHLSKEES---LNIEGLPSKGPIPPWLL--------------DIKYLSPLLL 371
++ Q K + + E+S LN++ L K LL +++ +S L
Sbjct: 223 NAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQ 282
Query: 372 AYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAK 431
A + + + LN +E+M ++QE ++ +E +++ + E+ +++ Q +
Sbjct: 283 AQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEE 342
Query: 432 LVLEENKLLLEQLEIQQRKAKDSHQERLQEVS-KLTKQLMLLEAKTHGQEK--ELAENRE 488
++ E+ + + Q E+ K+ RL+E+ + +++ LE K H QEK E E R+
Sbjct: 343 MMWEKEEKMRRQEEMMWE--KEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ 400
Query: 489 QLEILR--AKCQELKT---HSDGKIAVEVHKSIVNELKSQLQKE---------EEKERAE 534
+ E +R K QE + + KI + K E K Q+E EE++R E
Sbjct: 401 EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQE 460
Query: 535 MEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKA 594
EE+ + ++ Q++ + +K + EQ K + E E+ + K + E +++Q EK
Sbjct: 461 QEEMWRQEEKIREQEE-IWRQKEKMHEQEKIRKQE-EKVWRQEEKMHDQEEKIREQEEKM 518
Query: 595 MGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKV 654
E + + E I ++ + + + EK G + ++ ++ + EEK+
Sbjct: 519 WRQEEKIREQEEKIREQEEKIREQEEMMQ-----EQEEKMGEQEEKMQEQEKMRRQEEKI 573
Query: 655 KGYK---KQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQN 711
+ + ++ K+ + ++ EQ+E + +++ + + + E ++ +Q
Sbjct: 574 REQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE 633
Query: 712 REMEGELEVIWESTFR 727
+M + E +WE R
Sbjct: 634 EKMRRQEEKMWEQEVR 649
Score = 74.7 bits (182), Expect = 3e-13
Identities = 96/459 (20%), Positives = 206/459 (44%), Gaps = 53/459 (11%)
Query: 241 EALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPE 300
E LKE+N L Q + E + ++ +KEL+ KL E+ K L + + + + E
Sbjct: 217 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKL---ERAKLLLPQQQLQAEADHLGKE 273
Query: 301 LLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGL-PSKGPIPPW 359
L + + Q V+EN+ + ++ R + K + ++ E + + I
Sbjct: 274 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 333
Query: 360 LLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMF----------------RMRVQEVVK 403
++ ++ E+ M+ ++E+ +E+MR +M QE ++
Sbjct: 334 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIR 393
Query: 404 ENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQE-RLQEV 462
E EE QE K + +E RQ Q +AK+ +E K+ ++ +I++++ K QE ++ E
Sbjct: 394 EQEEKRQEEEK---IREQEKRQEQ-EAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ 449
Query: 463 SKLTKQLMLLEAKTHGQEKELAENREQLEILRAK-----------------CQELKTHS- 504
K+ ++ E + +++E + REQ EI R K QE K H
Sbjct: 450 EKIREEEKRQEQEEMWRQEE--KIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQ 507
Query: 505 DGKIAVEVHKSIVNELKSQLQ----KEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLT 560
+ KI + K E K + Q +E+E++ E EE+M++ +++ + E+ +
Sbjct: 508 EEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMR 567
Query: 561 EQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERD 620
Q + + + E+ ++ K +++ E + +Q EK E + + E + ++ +
Sbjct: 568 RQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE 627
Query: 621 SLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKK 659
+ + + +++ K+ + +RL + EEK++ +++
Sbjct: 628 KMQEQEEKMRRQEE----KMWEQEVRLRQQEEKMQEHQE 662
Score = 67.8 bits (164), Expect = 4e-11
Identities = 90/460 (19%), Positives = 206/460 (44%), Gaps = 66/460 (14%)
Query: 126 EEDIETQLSSSGKELGDVSAREDRGGHSDDLYAVPHRNQVPLLHEVNSEDDENISHQDGF 185
++ ++ + GKEL VSA+ L A N+ L + +N + +E + Q+
Sbjct: 260 QQQLQAEADHLGKELQSVSAK---------LQAQVEENE--LWNRLNQQQEEKMWRQE-- 306
Query: 186 PGSPPAPQRTQQKDGKHPVLNLKDEKPPLCEKPPPSPDITGRARQRYTEITREKFEALK- 244
++ Q+ + K +++++ + E+ + + R R E+ EK E ++
Sbjct: 307 -------EKIQEWEEK-----IQEQEEKIREQEEKIREQEEKMR-RQEEMMWEKEEKMRR 353
Query: 245 EENMDLNNMNQSLTLE--LNTMKQAMKELQLKLKGMEK---EKRKLKEAEKASSQEVAAP 299
+E M + LE + ++ ++EL+ K+ EK ++ K +E EK QE
Sbjct: 354 QEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 413
Query: 300 ELLYLRKQAQELVDENDGLKMTVHRL--NVELSRYQTKFRHLSKEESLNIEGLPSKGPIP 357
+ + +Q +++ ++ + ++ ++ E Q K R K +
Sbjct: 414 QEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQE----------E 463
Query: 358 PWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSA 417
W + K + E++ ++K++++ E R + ++V ++ E++H + K
Sbjct: 464 MWRQEEK-----IREQEEIWRQKEKMH-----EQEKIRKQEEKVWRQEEKMHDQEEKIRE 513
Query: 418 VTSEEWRQ---LQTQAKLVLEENKLLLEQLEIQQRKAKD--SHQERLQEVSKLTKQLMLL 472
+ WRQ ++ Q + + E+ + + EQ E+ Q + + +E++QE K+ +Q
Sbjct: 514 QEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQ---- 569
Query: 473 EAKTHGQEKELAENREQLEILRAKC--QELKTHSDGKIAVEVHKSIVNELKSQLQKEEEK 530
E K QE+++ E +E++ K QE K ++ E + + E + ++ ++EEK
Sbjct: 570 EEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMW-EQEEKMCEQEEK 628
Query: 531 ERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAEL 570
+ + E++ + + Q+ L ++ + E + LEA +
Sbjct: 629 MQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 668
Score = 56.2 bits (134), Expect = 1e-07
Identities = 60/293 (20%), Positives = 142/293 (48%), Gaps = 25/293 (8%)
Query: 448 QRKAKDSHQERLQ-EVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQEL--KTHS 504
++KA HQE L+ E+ + +L + + L ++ ++ L + ++L + H
Sbjct: 110 EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHD 169
Query: 505 DGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNK 564
K A E+ +++ S + +++K +EEL ++ L + + L E+N
Sbjct: 170 SWKFAGELEQAL-----SAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNA 224
Query: 565 ALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMC 624
L+ +L+ + + Q ++ LK+++E+A ++ Q L A+++ +E S+
Sbjct: 225 KLQEKLQLVESEKSEIQLNVKELKRKLERA---KLLLPQ--QQLQAEADHLGKELQSVSA 279
Query: 625 --LAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGK 682
A+ E+E LN+ + ++ + EEK++ +++ K+ + ++ EQ+E K
Sbjct: 280 KLQAQVEENELWNRLNQ--QQEEKMWRQEEKIQEWEE----KIQEQEEKIREQEE----K 329
Query: 683 TAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIREL 735
+ ++MR +++ +K+E + + + E E ++ + E + + +IREL
Sbjct: 330 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIREL 382
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 83.2 bits (204), Expect = 9e-16
Identities = 103/418 (24%), Positives = 195/418 (46%), Gaps = 58/418 (13%)
Query: 362 DIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSE 421
D+K ++ +++A++ M + A K + ++ M+V ++ N + +L +
Sbjct: 783 DLK-ITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKV---IQRNCAAYLKLR------NW 832
Query: 422 EWRQLQTQAKLVLE----ENKLLLEQLEIQ-----QRKAKDSHQERLQEVSKLTKQLMLL 472
+W +L T+ K +L+ E ++ ++ E+Q Q+KA++ +E Q+ S+LT++ LL
Sbjct: 833 QWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL 892
Query: 473 EAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELK--SQLQKEEEK 530
+ + + + AE E L AK QEL+ +I E+ + E QLQ E +K
Sbjct: 893 QEQLQAETELYAEAEEMRVRLAAKKQELE-----EILHEMEARLEEEEDRGQQLQAERKK 947
Query: 531 ERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQ 590
+M +L E+L +A ++ L LEK + + K LE E+ N K K+ ++L+++
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1007
Query: 591 VEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKL 650
+ N LA A+N+T+ ++ + + SE + L K KS L KL
Sbjct: 1008 ISDLTTN-------LAEEEEKAKNLTKLKNK----HESMISELEVRLKKEEKSRQELEKL 1056
Query: 651 EEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQ 710
+ K++G ++ D+ ++ E + A K + + + L + K + AL++
Sbjct: 1057 KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK----NNALKK 1112
Query: 711 NREMEGELEVIWESTFRE-------NRRIREL----------LQDTLTRTGVQDNPRA 751
RE+EG + + E E ++ R+L L+DTL T Q RA
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1170
Score = 80.5 bits (197), Expect = 6e-15
Identities = 115/526 (21%), Positives = 237/526 (45%), Gaps = 62/526 (11%)
Query: 257 LTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPELLYLRKQAQ-ELVDEN 315
+T + M+ ELQ + +K + +LKE E+ SQ LL + QA+ EL E
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 316 DGLKMTVHRLNVELSRYQTKFR-HLSKEESLNIEGLPSKGPIPPWLLDIK-YLSPLLLAY 373
+ +++ + EL + L +EE + + + +LD++ L A
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966
Query: 374 EDMMKEKDELNATLK---EEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQA 430
+ + EK A +K +E+ + + ++ KE + L + ++ + +EE + +
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 431 KLVLEENKLLLEQLEIQQRKAKDSHQE------RLQ-EVSKLTKQLMLLEAKTHGQEKEL 483
KL +++ ++ +LE++ +K + S QE +L+ + S +Q+ L+A+ + +L
Sbjct: 1027 KLK-NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1085
Query: 484 AENREQLEILRA--------------KCQELKTH-SDGKIAVEVHKSIVNELKSQ---LQ 525
A+ E+L+ A K +EL+ H SD + ++ ++ N+ + Q L
Sbjct: 1086 AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1145
Query: 526 KEEEKERAEMEELMEKLTVLQA----QKKSLLLEKNSLTEQNKALEAELERAQKINRKSQ 581
+E E + E+E+ ++ Q +++ + + K +L E+ ++ EA++ Q++ +K
Sbjct: 1146 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV---QEMRQKHA 1202
Query: 582 KKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVI 641
+ +E L +Q+E+ + ANL + + +E L + L K V +K
Sbjct: 1203 QAVEELTEQLEQFKRAK-------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255
Query: 642 KSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAG-------KTAQYRQEMRHLH 694
K ++ +L+ K ++ A +L D H+L + E G K + +++ L
Sbjct: 1256 KLEAQVQELQSKCSDGERARA-ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1314
Query: 695 QVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDTL 740
L+D QE+L + +Q + +L + E R LQD L
Sbjct: 1315 SQLQDTQELLQEETRQKLNVSTKLRQLEEE--------RNSLQDQL 1352
Score = 78.2 bits (191), Expect = 3e-14
Identities = 122/589 (20%), Positives = 247/589 (41%), Gaps = 95/589 (16%)
Query: 166 PLLHEVNSEDDENISHQDGFPGSPPAPQRTQQK----DGKHPVLNLKDEKPPLCEKPPPS 221
PLL +V +++E + +D + Q+ + + + KH L +EK L E+
Sbjct: 843 PLL-QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHS--QLTEEKNLLQEQLQAE 899
Query: 222 PDITGRA----------RQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKEL 271
++ A +Q EI E L+EE + Q L E M Q M +L
Sbjct: 900 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE----DRGQQLQAERKKMAQQMLDL 955
Query: 272 QLKLKGMEKEKRKLKEAEKASSQ---EVAAPELLYLRKQAQELVDENDGLKMTVHRLNVE 328
+ +L+ E ++KL + EK +++ + E+L + Q +L E L+ + L
Sbjct: 956 EEQLEEEEAARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 329 LSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLK 388
L+ + K ++L+K ++ + E + S+ L L E +E ++L L+
Sbjct: 1015 LAEEEEKAKNLTKLKNKH-ESMISE------------LEVRLKKEEKSRQELEKLKRKLE 1061
Query: 389 EEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQ 448
+ F ++ ++ + EL +L K ++ + QA L ++++ + +++
Sbjct: 1062 GDASDFHEQIADLQAQIAELKMQLAK---------KEEELQAALARLDDEIAQKNNALKK 1112
Query: 449 RKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKC----------Q 498
+ + H +S L + L A + EK+ + E+LE L+ + Q
Sbjct: 1113 IRELEGH------ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1166
Query: 499 ELKTHSDGKIAVEVHKSIVNELKS---QLQKEEEKERAEMEELMEKLTVLQAQKKSLLLE 555
EL+ + ++ V + K++ E +S Q+Q+ +K +EEL E+L + K +L
Sbjct: 1167 ELRAKREQEVTV-LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 556 KNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENI 615
K +L ++N L EL + ++ + K + L+ QV++ + A L +
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285
Query: 616 TQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQ 675
E +S+ G+LN+ I+L K + +S +L +
Sbjct: 1286 QNEVESV-----------TGMLNEAEGKAIKLAK--------------DVASLSSQLQDT 1320
Query: 676 QEDFAGKTAQ---YRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVI 721
QE +T Q ++R L + Q+ LD+ ++ + +E + +
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369
Score = 75.1 bits (183), Expect = 2e-13
Identities = 104/501 (20%), Positives = 215/501 (42%), Gaps = 47/501 (9%)
Query: 254 NQSLTLELN-TMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPEL----LYLRKQA 308
+Q L E N + K A + + + + EKE + L A A EL L+ +
Sbjct: 1454 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1513
Query: 309 QELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSP 368
++LV D + VH L +T+ + K + +E L++ +
Sbjct: 1514 EDLVSSKDDVGKNVHELEKSKRALETQMEEM-KTQLEELEDELQATEDAKLRLEVN-MQA 1571
Query: 369 LLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSE---EWRQ 425
L +E ++ +DE N +E+ R + ++ E E E+ ++ ++A + + +
Sbjct: 1572 LKGQFERDLQARDEQN---EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628
Query: 426 LQTQAKLVLEENKLLLEQLEIQQRKAKD----------SHQERLQEVSKLTKQLMLLEAK 475
L+ QA ++ + ++QL Q + KD S E + K+ LEA
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1688
Query: 476 THGQEKELA---ENREQLEILRAK-CQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKE 531
+++LA R+Q ++ + + +EL + G+ A++ K + +QL++E E+E
Sbjct: 1689 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1748
Query: 532 RAEMEELMEKLTVLQAQKKSL---LLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLK 588
+ ME + +++ Q + L L + S ++N++ +LER N++ + K+ ++
Sbjct: 1749 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ---NKELRSKLHEME 1805
Query: 589 KQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLG 648
V+ + ++A + A + L E + QE K L+ +KD L +++
Sbjct: 1806 GAVKSKFKSTIAALE--AKIAQLEEQVEQEAREKQAATKSLK-QKDKKLKEILLQVEDER 1862
Query: 649 KLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQAL 708
K+ E+ K ++ ++ + +L E +E E + ++ + Q LD+A
Sbjct: 1863 KMAEQYKEQAEKGNARVKQLKRQLEEAEE-----------ESQRINANRRKLQRELDEAT 1911
Query: 709 QQNREMEGELEVIWESTFREN 729
+ N M E+ + R N
Sbjct: 1912 ESNEAMGREVNALKSKLRRGN 1932
Score = 54.7 bits (130), Expect = 3e-07
Identities = 83/422 (19%), Positives = 175/422 (41%), Gaps = 51/422 (12%)
Query: 227 RARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMK-QAMKELQLKLKGMEKEKRKL 285
RA + E + + E L++E + L + + +K Q ++LQ + + E+++R+L
Sbjct: 1535 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1594
Query: 286 KE----------------AEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVEL 329
+ A A++++ +L L QA + + + +L ++
Sbjct: 1595 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1654
Query: 330 SRYQTKFRHL-SKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMK----EKDEL- 383
+Q + + + + ++ D+ L L A E K EK+EL
Sbjct: 1655 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1714
Query: 384 ---------NATLKEEMRMFRMRVQEVVKENEE-------LHQELNKSSAVTSEEWRQLQ 427
L++E R R+ ++ +E EE + + K++ + +L
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774
Query: 428 TQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEV-SKLTKQLMLLEAKTHGQEKELA-E 485
T+ + ++N+ +QLE Q ++ + E V SK + LEAK E+++ E
Sbjct: 1775 TE-RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833
Query: 486 NREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERA---EMEELMEKL 542
RE+ ++ Q+ K + + VE + + + K Q +K + + ++EE E+
Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1893
Query: 543 TVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQ------VEKAMG 596
+ A ++ L E + TE N+A+ E+ + R+ + V ++ +E A G
Sbjct: 1894 QRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADG 1953
Query: 597 NE 598
+E
Sbjct: 1954 SE 1955
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 83.2 bits (204), Expect = 9e-16
Identities = 103/418 (24%), Positives = 195/418 (46%), Gaps = 58/418 (13%)
Query: 362 DIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSE 421
D+K ++ +++A++ M + A K + ++ M+V ++ N + +L +
Sbjct: 790 DLK-ITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKV---IQRNCAAYLKLR------NW 839
Query: 422 EWRQLQTQAKLVLE----ENKLLLEQLEIQ-----QRKAKDSHQERLQEVSKLTKQLMLL 472
+W +L T+ K +L+ E ++ ++ E+Q Q+KA++ +E Q+ S+LT++ LL
Sbjct: 840 QWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL 899
Query: 473 EAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELK--SQLQKEEEK 530
+ + + + AE E L AK QEL+ +I E+ + E QLQ E +K
Sbjct: 900 QEQLQAETELYAEAEEMRVRLAAKKQELE-----EILHEMEARLEEEEDRGQQLQAERKK 954
Query: 531 ERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQ 590
+M +L E+L +A ++ L LEK + + K LE E+ N K K+ ++L+++
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014
Query: 591 VEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKL 650
+ N LA A+N+T+ ++ + + SE + L K KS L KL
Sbjct: 1015 ISDLTTN-------LAEEEEKAKNLTKLKNK----HESMISELEVRLKKEEKSRQELEKL 1063
Query: 651 EEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQ 710
+ K++G ++ D+ ++ E + A K + + + L + K + AL++
Sbjct: 1064 KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK----NNALKK 1119
Query: 711 NREMEGELEVIWESTFRE-------NRRIREL----------LQDTLTRTGVQDNPRA 751
RE+EG + + E E ++ R+L L+DTL T Q RA
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1177
Score = 80.5 bits (197), Expect = 6e-15
Identities = 115/526 (21%), Positives = 237/526 (45%), Gaps = 62/526 (11%)
Query: 257 LTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPELLYLRKQAQ-ELVDEN 315
+T + M+ ELQ + +K + +LKE E+ SQ LL + QA+ EL E
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 316 DGLKMTVHRLNVELSRYQTKFR-HLSKEESLNIEGLPSKGPIPPWLLDIK-YLSPLLLAY 373
+ +++ + EL + L +EE + + + +LD++ L A
Sbjct: 914 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973
Query: 374 EDMMKEKDELNATLK---EEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQA 430
+ + EK A +K +E+ + + ++ KE + L + ++ + +EE + +
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 431 KLVLEENKLLLEQLEIQQRKAKDSHQE------RLQ-EVSKLTKQLMLLEAKTHGQEKEL 483
KL +++ ++ +LE++ +K + S QE +L+ + S +Q+ L+A+ + +L
Sbjct: 1034 KLK-NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1092
Query: 484 AENREQLEILRA--------------KCQELKTH-SDGKIAVEVHKSIVNELKSQ---LQ 525
A+ E+L+ A K +EL+ H SD + ++ ++ N+ + Q L
Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1152
Query: 526 KEEEKERAEMEELMEKLTVLQA----QKKSLLLEKNSLTEQNKALEAELERAQKINRKSQ 581
+E E + E+E+ ++ Q +++ + + K +L E+ ++ EA++ Q++ +K
Sbjct: 1153 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV---QEMRQKHA 1209
Query: 582 KKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVI 641
+ +E L +Q+E+ + ANL + + +E L + L K V +K
Sbjct: 1210 QAVEELTEQLEQFKRAK-------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262
Query: 642 KSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAG-------KTAQYRQEMRHLH 694
K ++ +L+ K ++ A +L D H+L + E G K + +++ L
Sbjct: 1263 KLEAQVQELQSKCSDGERARA-ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1321
Query: 695 QVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDTL 740
L+D QE+L + +Q + +L + E R LQD L
Sbjct: 1322 SQLQDTQELLQEETRQKLNVSTKLRQLEEE--------RNSLQDQL 1359
Score = 78.2 bits (191), Expect = 3e-14
Identities = 122/589 (20%), Positives = 247/589 (41%), Gaps = 95/589 (16%)
Query: 166 PLLHEVNSEDDENISHQDGFPGSPPAPQRTQQK----DGKHPVLNLKDEKPPLCEKPPPS 221
PLL +V +++E + +D + Q+ + + + KH L +EK L E+
Sbjct: 850 PLL-QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHS--QLTEEKNLLQEQLQAE 906
Query: 222 PDITGRA----------RQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKEL 271
++ A +Q EI E L+EE + Q L E M Q M +L
Sbjct: 907 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE----DRGQQLQAERKKMAQQMLDL 962
Query: 272 QLKLKGMEKEKRKLKEAEKASSQ---EVAAPELLYLRKQAQELVDENDGLKMTVHRLNVE 328
+ +L+ E ++KL + EK +++ + E+L + Q +L E L+ + L
Sbjct: 963 EEQLEEEEAARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 329 LSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLK 388
L+ + K ++L+K ++ + E + S+ L L E +E ++L L+
Sbjct: 1022 LAEEEEKAKNLTKLKNKH-ESMISE------------LEVRLKKEEKSRQELEKLKRKLE 1068
Query: 389 EEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQ 448
+ F ++ ++ + EL +L K ++ + QA L ++++ + +++
Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQLAK---------KEEELQAALARLDDEIAQKNNALKK 1119
Query: 449 RKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKC----------Q 498
+ + H +S L + L A + EK+ + E+LE L+ + Q
Sbjct: 1120 IRELEGH------ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1173
Query: 499 ELKTHSDGKIAVEVHKSIVNELKS---QLQKEEEKERAEMEELMEKLTVLQAQKKSLLLE 555
EL+ + ++ V + K++ E +S Q+Q+ +K +EEL E+L + K +L
Sbjct: 1174 ELRAKREQEVTV-LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 556 KNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENI 615
K +L ++N L EL + ++ + K + L+ QV++ + A L +
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292
Query: 616 TQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQ 675
E +S+ G+LN+ I+L K + +S +L +
Sbjct: 1293 QNEVESV-----------TGMLNEAEGKAIKLAK--------------DVASLSSQLQDT 1327
Query: 676 QEDFAGKTAQ---YRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVI 721
QE +T Q ++R L + Q+ LD+ ++ + +E + +
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376
Score = 75.1 bits (183), Expect = 2e-13
Identities = 104/501 (20%), Positives = 215/501 (42%), Gaps = 47/501 (9%)
Query: 254 NQSLTLELN-TMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPEL----LYLRKQA 308
+Q L E N + K A + + + + EKE + L A A EL L+ +
Sbjct: 1461 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1520
Query: 309 QELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSP 368
++LV D + VH L +T+ + K + +E L++ +
Sbjct: 1521 EDLVSSKDDVGKNVHELEKSKRALETQMEEM-KTQLEELEDELQATEDAKLRLEVN-MQA 1578
Query: 369 LLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSE---EWRQ 425
L +E ++ +DE N +E+ R + ++ E E E+ ++ ++A + + +
Sbjct: 1579 LKGQFERDLQARDEQN---EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635
Query: 426 LQTQAKLVLEENKLLLEQLEIQQRKAKD----------SHQERLQEVSKLTKQLMLLEAK 475
L+ QA ++ + ++QL Q + KD S E + K+ LEA
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1695
Query: 476 THGQEKELA---ENREQLEILRAK-CQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKE 531
+++LA R+Q ++ + + +EL + G+ A++ K + +QL++E E+E
Sbjct: 1696 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1755
Query: 532 RAEMEELMEKLTVLQAQKKSL---LLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLK 588
+ ME + +++ Q + L L + S ++N++ +LER N++ + K+ ++
Sbjct: 1756 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ---NKELRSKLHEME 1812
Query: 589 KQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLG 648
V+ + ++A + A + L E + QE K L+ +KD L +++
Sbjct: 1813 GAVKSKFKSTIAALE--AKIAQLEEQVEQEAREKQAATKSLK-QKDKKLKEILLQVEDER 1869
Query: 649 KLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQAL 708
K+ E+ K ++ ++ + +L E +E E + ++ + Q LD+A
Sbjct: 1870 KMAEQYKEQAEKGNARVKQLKRQLEEAEE-----------ESQRINANRRKLQRELDEAT 1918
Query: 709 QQNREMEGELEVIWESTFREN 729
+ N M E+ + R N
Sbjct: 1919 ESNEAMGREVNALKSKLRRGN 1939
Score = 54.7 bits (130), Expect = 3e-07
Identities = 83/422 (19%), Positives = 175/422 (41%), Gaps = 51/422 (12%)
Query: 227 RARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMK-QAMKELQLKLKGMEKEKRKL 285
RA + E + + E L++E + L + + +K Q ++LQ + + E+++R+L
Sbjct: 1542 RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1601
Query: 286 KE----------------AEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVEL 329
+ A A++++ +L L QA + + + +L ++
Sbjct: 1602 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1661
Query: 330 SRYQTKFRHL-SKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMK----EKDEL- 383
+Q + + + + ++ D+ L L A E K EK+EL
Sbjct: 1662 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1721
Query: 384 ---------NATLKEEMRMFRMRVQEVVKENEE-------LHQELNKSSAVTSEEWRQLQ 427
L++E R R+ ++ +E EE + + K++ + +L
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781
Query: 428 TQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEV-SKLTKQLMLLEAKTHGQEKELA-E 485
T+ + ++N+ +QLE Q ++ + E V SK + LEAK E+++ E
Sbjct: 1782 TE-RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840
Query: 486 NREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERA---EMEELMEKL 542
RE+ ++ Q+ K + + VE + + + K Q +K + + ++EE E+
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900
Query: 543 TVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQ------VEKAMG 596
+ A ++ L E + TE N+A+ E+ + R+ + V ++ +E A G
Sbjct: 1901 QRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADG 1960
Query: 597 NE 598
+E
Sbjct: 1961 SE 1962
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 83.2 bits (204), Expect = 9e-16
Identities = 103/418 (24%), Positives = 195/418 (46%), Gaps = 58/418 (13%)
Query: 362 DIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSE 421
D+K ++ +++A++ M + A K + ++ M+V ++ N + +L +
Sbjct: 790 DLK-ITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKV---IQRNCAAYLKLR------NW 839
Query: 422 EWRQLQTQAKLVLE----ENKLLLEQLEIQ-----QRKAKDSHQERLQEVSKLTKQLMLL 472
+W +L T+ K +L+ E ++ ++ E+Q Q+KA++ +E Q+ S+LT++ LL
Sbjct: 840 QWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL 899
Query: 473 EAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELK--SQLQKEEEK 530
+ + + + AE E L AK QEL+ +I E+ + E QLQ E +K
Sbjct: 900 QEQLQAETELYAEAEEMRVRLAAKKQELE-----EILHEMEARLEEEEDRGQQLQAERKK 954
Query: 531 ERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQ 590
+M +L E+L +A ++ L LEK + + K LE E+ N K K+ ++L+++
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014
Query: 591 VEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKL 650
+ N LA A+N+T+ ++ + + SE + L K KS L KL
Sbjct: 1015 ISDLTTN-------LAEEEEKAKNLTKLKNK----HESMISELEVRLKKEEKSRQELEKL 1063
Query: 651 EEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQ 710
+ K++G ++ D+ ++ E + A K + + + L + K + AL++
Sbjct: 1064 KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK----NNALKK 1119
Query: 711 NREMEGELEVIWESTFRE-------NRRIREL----------LQDTLTRTGVQDNPRA 751
RE+EG + + E E ++ R+L L+DTL T Q RA
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1177
Score = 80.5 bits (197), Expect = 6e-15
Identities = 115/526 (21%), Positives = 237/526 (45%), Gaps = 62/526 (11%)
Query: 257 LTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPELLYLRKQAQ-ELVDEN 315
+T + M+ ELQ + +K + +LKE E+ SQ LL + QA+ EL E
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 316 DGLKMTVHRLNVELSRYQTKFR-HLSKEESLNIEGLPSKGPIPPWLLDIK-YLSPLLLAY 373
+ +++ + EL + L +EE + + + +LD++ L A
Sbjct: 914 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973
Query: 374 EDMMKEKDELNATLK---EEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQA 430
+ + EK A +K +E+ + + ++ KE + L + ++ + +EE + +
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 431 KLVLEENKLLLEQLEIQQRKAKDSHQE------RLQ-EVSKLTKQLMLLEAKTHGQEKEL 483
KL +++ ++ +LE++ +K + S QE +L+ + S +Q+ L+A+ + +L
Sbjct: 1034 KLK-NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1092
Query: 484 AENREQLEILRA--------------KCQELKTH-SDGKIAVEVHKSIVNELKSQ---LQ 525
A+ E+L+ A K +EL+ H SD + ++ ++ N+ + Q L
Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1152
Query: 526 KEEEKERAEMEELMEKLTVLQA----QKKSLLLEKNSLTEQNKALEAELERAQKINRKSQ 581
+E E + E+E+ ++ Q +++ + + K +L E+ ++ EA++ Q++ +K
Sbjct: 1153 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV---QEMRQKHA 1209
Query: 582 KKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVI 641
+ +E L +Q+E+ + ANL + + +E L + L K V +K
Sbjct: 1210 QAVEELTEQLEQFKRAK-------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262
Query: 642 KSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAG-------KTAQYRQEMRHLH 694
K ++ +L+ K ++ A +L D H+L + E G K + +++ L
Sbjct: 1263 KLEAQVQELQSKCSDGERARA-ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1321
Query: 695 QVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDTL 740
L+D QE+L + +Q + +L + E R LQD L
Sbjct: 1322 SQLQDTQELLQEETRQKLNVSTKLRQLEEE--------RNSLQDQL 1359
Score = 78.2 bits (191), Expect = 3e-14
Identities = 122/589 (20%), Positives = 247/589 (41%), Gaps = 95/589 (16%)
Query: 166 PLLHEVNSEDDENISHQDGFPGSPPAPQRTQQK----DGKHPVLNLKDEKPPLCEKPPPS 221
PLL +V +++E + +D + Q+ + + + KH L +EK L E+
Sbjct: 850 PLL-QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHS--QLTEEKNLLQEQLQAE 906
Query: 222 PDITGRA----------RQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKEL 271
++ A +Q EI E L+EE + Q L E M Q M +L
Sbjct: 907 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE----DRGQQLQAERKKMAQQMLDL 962
Query: 272 QLKLKGMEKEKRKLKEAEKASSQ---EVAAPELLYLRKQAQELVDENDGLKMTVHRLNVE 328
+ +L+ E ++KL + EK +++ + E+L + Q +L E L+ + L
Sbjct: 963 EEQLEEEEAARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 329 LSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLK 388
L+ + K ++L+K ++ + E + S+ L L E +E ++L L+
Sbjct: 1022 LAEEEEKAKNLTKLKNKH-ESMISE------------LEVRLKKEEKSRQELEKLKRKLE 1068
Query: 389 EEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQ 448
+ F ++ ++ + EL +L K ++ + QA L ++++ + +++
Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQLAK---------KEEELQAALARLDDEIAQKNNALKK 1119
Query: 449 RKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKC----------Q 498
+ + H +S L + L A + EK+ + E+LE L+ + Q
Sbjct: 1120 IRELEGH------ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1173
Query: 499 ELKTHSDGKIAVEVHKSIVNELKS---QLQKEEEKERAEMEELMEKLTVLQAQKKSLLLE 555
EL+ + ++ V + K++ E +S Q+Q+ +K +EEL E+L + K +L
Sbjct: 1174 ELRAKREQEVTV-LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 556 KNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENI 615
K +L ++N L EL + ++ + K + L+ QV++ + A L +
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292
Query: 616 TQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQ 675
E +S+ G+LN+ I+L K + +S +L +
Sbjct: 1293 QNEVESV-----------TGMLNEAEGKAIKLAK--------------DVASLSSQLQDT 1327
Query: 676 QEDFAGKTAQ---YRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVI 721
QE +T Q ++R L + Q+ LD+ ++ + +E + +
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376
Score = 74.3 bits (181), Expect = 4e-13
Identities = 102/493 (20%), Positives = 213/493 (43%), Gaps = 47/493 (9%)
Query: 254 NQSLTLELN-TMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPEL----LYLRKQA 308
+Q L E N + K A + + + + EKE + L A A EL L+ +
Sbjct: 1461 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1520
Query: 309 QELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSP 368
++LV D + VH L +T+ + K + +E L++ +
Sbjct: 1521 EDLVSSKDDVGKNVHELEKSKRALETQMEEM-KTQLEELEDELQATEDAKLRLEVN-MQA 1578
Query: 369 LLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSE---EWRQ 425
L +E ++ +DE N +E+ R + ++ E E E+ ++ ++A + + +
Sbjct: 1579 LKGQFERDLQARDEQN---EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635
Query: 426 LQTQAKLVLEENKLLLEQLEIQQRKAKD----------SHQERLQEVSKLTKQLMLLEAK 475
L+ QA ++ + ++QL Q + KD S E + K+ LEA
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1695
Query: 476 THGQEKELA---ENREQLEILRAK-CQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKE 531
+++LA R+Q ++ + + +EL + G+ A++ K + +QL++E E+E
Sbjct: 1696 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1755
Query: 532 RAEMEELMEKLTVLQAQKKSL---LLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLK 588
+ ME + +++ Q + L L + S ++N++ +LER N++ + K+ ++
Sbjct: 1756 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ---NKELRSKLHEME 1812
Query: 589 KQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLG 648
V+ + ++A + A + L E + QE K L+ +KD L +++
Sbjct: 1813 GAVKSKFKSTIAALE--AKIAQLEEQVEQEAREKQAATKSLK-QKDKKLKEILLQVEDER 1869
Query: 649 KLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQAL 708
K+ E+ K ++ ++ + +L E +E E + ++ + Q LD+A
Sbjct: 1870 KMAEQYKEQAEKGNARVKQLKRQLEEAEE-----------ESQRINANRRKLQRELDEAT 1918
Query: 709 QQNREMEGELEVI 721
+ N M E+ +
Sbjct: 1919 ESNEAMGREVNAL 1931
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 83.2 bits (204), Expect = 9e-16
Identities = 103/418 (24%), Positives = 195/418 (46%), Gaps = 58/418 (13%)
Query: 362 DIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSE 421
D+K ++ +++A++ M + A K + ++ M+V ++ N + +L +
Sbjct: 783 DLK-ITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKV---IQRNCAAYLKLR------NW 832
Query: 422 EWRQLQTQAKLVLE----ENKLLLEQLEIQ-----QRKAKDSHQERLQEVSKLTKQLMLL 472
+W +L T+ K +L+ E ++ ++ E+Q Q+KA++ +E Q+ S+LT++ LL
Sbjct: 833 QWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL 892
Query: 473 EAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELK--SQLQKEEEK 530
+ + + + AE E L AK QEL+ +I E+ + E QLQ E +K
Sbjct: 893 QEQLQAETELYAEAEEMRVRLAAKKQELE-----EILHEMEARLEEEEDRGQQLQAERKK 947
Query: 531 ERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQ 590
+M +L E+L +A ++ L LEK + + K LE E+ N K K+ ++L+++
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1007
Query: 591 VEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKL 650
+ N LA A+N+T+ ++ + + SE + L K KS L KL
Sbjct: 1008 ISDLTTN-------LAEEEEKAKNLTKLKNK----HESMISELEVRLKKEEKSRQELEKL 1056
Query: 651 EEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQ 710
+ K++G ++ D+ ++ E + A K + + + L + K + AL++
Sbjct: 1057 KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK----NNALKK 1112
Query: 711 NREMEGELEVIWESTFRE-------NRRIREL----------LQDTLTRTGVQDNPRA 751
RE+EG + + E E ++ R+L L+DTL T Q RA
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA 1170
Score = 80.5 bits (197), Expect = 6e-15
Identities = 115/526 (21%), Positives = 237/526 (45%), Gaps = 62/526 (11%)
Query: 257 LTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPELLYLRKQAQ-ELVDEN 315
+T + M+ ELQ + +K + +LKE E+ SQ LL + QA+ EL E
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 316 DGLKMTVHRLNVELSRYQTKFR-HLSKEESLNIEGLPSKGPIPPWLLDIK-YLSPLLLAY 373
+ +++ + EL + L +EE + + + +LD++ L A
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966
Query: 374 EDMMKEKDELNATLK---EEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQA 430
+ + EK A +K +E+ + + ++ KE + L + ++ + +EE + +
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 431 KLVLEENKLLLEQLEIQQRKAKDSHQE------RLQ-EVSKLTKQLMLLEAKTHGQEKEL 483
KL +++ ++ +LE++ +K + S QE +L+ + S +Q+ L+A+ + +L
Sbjct: 1027 KLK-NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1085
Query: 484 AENREQLEILRA--------------KCQELKTH-SDGKIAVEVHKSIVNELKSQ---LQ 525
A+ E+L+ A K +EL+ H SD + ++ ++ N+ + Q L
Sbjct: 1086 AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1145
Query: 526 KEEEKERAEMEELMEKLTVLQA----QKKSLLLEKNSLTEQNKALEAELERAQKINRKSQ 581
+E E + E+E+ ++ Q +++ + + K +L E+ ++ EA++ Q++ +K
Sbjct: 1146 EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV---QEMRQKHA 1202
Query: 582 KKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVI 641
+ +E L +Q+E+ + ANL + + +E L + L K V +K
Sbjct: 1203 QAVEELTEQLEQFKRAK-------ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255
Query: 642 KSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAG-------KTAQYRQEMRHLH 694
K ++ +L+ K ++ A +L D H+L + E G K + +++ L
Sbjct: 1256 KLEAQVQELQSKCSDGERARA-ELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1314
Query: 695 QVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDTL 740
L+D QE+L + +Q + +L + E R LQD L
Sbjct: 1315 SQLQDTQELLQEETRQKLNVSTKLRQLEEE--------RNSLQDQL 1352
Score = 78.2 bits (191), Expect = 3e-14
Identities = 122/589 (20%), Positives = 247/589 (41%), Gaps = 95/589 (16%)
Query: 166 PLLHEVNSEDDENISHQDGFPGSPPAPQRTQQK----DGKHPVLNLKDEKPPLCEKPPPS 221
PLL +V +++E + +D + Q+ + + + KH L +EK L E+
Sbjct: 843 PLL-QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHS--QLTEEKNLLQEQLQAE 899
Query: 222 PDITGRA----------RQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKEL 271
++ A +Q EI E L+EE + Q L E M Q M +L
Sbjct: 900 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE----DRGQQLQAERKKMAQQMLDL 955
Query: 272 QLKLKGMEKEKRKLKEAEKASSQ---EVAAPELLYLRKQAQELVDENDGLKMTVHRLNVE 328
+ +L+ E ++KL + EK +++ + E+L + Q +L E L+ + L
Sbjct: 956 EEQLEEEEAARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 329 LSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLK 388
L+ + K ++L+K ++ + E + S+ L L E +E ++L L+
Sbjct: 1015 LAEEEEKAKNLTKLKNKH-ESMISE------------LEVRLKKEEKSRQELEKLKRKLE 1061
Query: 389 EEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQ 448
+ F ++ ++ + EL +L K ++ + QA L ++++ + +++
Sbjct: 1062 GDASDFHEQIADLQAQIAELKMQLAK---------KEEELQAALARLDDEIAQKNNALKK 1112
Query: 449 RKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKC----------Q 498
+ + H +S L + L A + EK+ + E+LE L+ + Q
Sbjct: 1113 IRELEGH------ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1166
Query: 499 ELKTHSDGKIAVEVHKSIVNELKS---QLQKEEEKERAEMEELMEKLTVLQAQKKSLLLE 555
EL+ + ++ V + K++ E +S Q+Q+ +K +EEL E+L + K +L
Sbjct: 1167 ELRAKREQEVTV-LKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 556 KNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENI 615
K +L ++N L EL + ++ + K + L+ QV++ + A L +
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285
Query: 616 TQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQ 675
E +S+ G+LN+ I+L K + +S +L +
Sbjct: 1286 QNEVESV-----------TGMLNEAEGKAIKLAK--------------DVASLSSQLQDT 1320
Query: 676 QEDFAGKTAQ---YRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVI 721
QE +T Q ++R L + Q+ LD+ ++ + +E + +
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369
Score = 74.3 bits (181), Expect = 4e-13
Identities = 102/493 (20%), Positives = 213/493 (43%), Gaps = 47/493 (9%)
Query: 254 NQSLTLELN-TMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPEL----LYLRKQA 308
+Q L E N + K A + + + + EKE + L A A EL L+ +
Sbjct: 1454 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1513
Query: 309 QELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSP 368
++LV D + VH L +T+ + K + +E L++ +
Sbjct: 1514 EDLVSSKDDVGKNVHELEKSKRALETQMEEM-KTQLEELEDELQATEDAKLRLEVN-MQA 1571
Query: 369 LLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSE---EWRQ 425
L +E ++ +DE N +E+ R + ++ E E E+ ++ ++A + + +
Sbjct: 1572 LKGQFERDLQARDEQN---EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628
Query: 426 LQTQAKLVLEENKLLLEQLEIQQRKAKD----------SHQERLQEVSKLTKQLMLLEAK 475
L+ QA ++ + ++QL Q + KD S E + K+ LEA
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1688
Query: 476 THGQEKELA---ENREQLEILRAK-CQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKE 531
+++LA R+Q ++ + + +EL + G+ A++ K + +QL++E E+E
Sbjct: 1689 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1748
Query: 532 RAEMEELMEKLTVLQAQKKSL---LLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLK 588
+ ME + +++ Q + L L + S ++N++ +LER N++ + K+ ++
Sbjct: 1749 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ---NKELRSKLHEME 1805
Query: 589 KQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLG 648
V+ + ++A + A + L E + QE K L+ +KD L +++
Sbjct: 1806 GAVKSKFKSTIAALE--AKIAQLEEQVEQEAREKQAATKSLK-QKDKKLKEILLQVEDER 1862
Query: 649 KLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQAL 708
K+ E+ K ++ ++ + +L E +E E + ++ + Q LD+A
Sbjct: 1863 KMAEQYKEQAEKGNARVKQLKRQLEEAEE-----------ESQRINANRRKLQRELDEAT 1911
Query: 709 QQNREMEGELEVI 721
+ N M E+ +
Sbjct: 1912 ESNEAMGREVNAL 1924
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 82.4 bits (202), Expect = 1e-15
Identities = 121/558 (21%), Positives = 224/558 (40%), Gaps = 100/558 (17%)
Query: 223 DITGRARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEK 282
DI + Q+ E + +K + L+ E DL NQ T+++ ++EL++ K +E+ +
Sbjct: 762 DIENQRLQKTLENSNKKIQQLESELQDLEMENQ-------TLQKNLEELKISSKRLEQLE 814
Query: 283 RKLKEAEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKE 342
++ K E+ +SQ L K ++L EN L+ + L K +L KE
Sbjct: 815 KENKSLEQETSQ---------LEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865
Query: 343 ESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVV 402
K LS + Y++ EL KE ++ + ++ +V
Sbjct: 866 N--------------------KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLV 905
Query: 403 KENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQR-KAKDSHQERLQE 461
E+L E K+ + ++ + K+ L + +LL ++ R K +S E
Sbjct: 906 TLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLE---- 961
Query: 462 VSKLTKQLMLLEAKTHGQEKELAEN-------REQLEILRAKCQELKTHSDGKIAVEVHK 514
S L K L + E K E L E+ R++L+ ++ + LK D + V+
Sbjct: 962 -STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSP 1020
Query: 515 SIVNE---------------LK------------SQLQKEEEKERAEMEELMEKLTVLQA 547
I E LK + LQ E++ + ++++L + LQA
Sbjct: 1021 PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQA 1080
Query: 548 QKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLAN 607
Q +L + SL EQN L+ + N K Q + L Q M ++
Sbjct: 1081 QILALQRQTVSLQEQNTTLQTQ-------NAKLQVENSTLNSQSTSLMNQNAQLLIQQSS 1133
Query: 608 LVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGD 667
L E++ +ER+ L L + +IK + +L L E+ + K G
Sbjct: 1134 LENENESVIKEREDLKSL-----------YDSLIKDHEKLELLHERQASEYESLISKHGT 1182
Query: 668 I--SHRLLEQQ----EDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVI 721
+ +H+ LE + ED + + + ++ L ++LK +QE + + + + E + +
Sbjct: 1183 LKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKL 1242
Query: 722 WESTFRENRRIRELLQDT 739
R N +LL++T
Sbjct: 1243 CGENDRLNHTYSQLLKET 1260
Score = 79.3 bits (194), Expect = 1e-14
Identities = 120/527 (22%), Positives = 242/527 (45%), Gaps = 81/527 (15%)
Query: 234 EITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKE---LQLKLKGMEKEKRKLKEAEK 290
++ R+K E L EENM TLE+ KQ+M E L +L+ + + + +K
Sbjct: 399 DMDRKKIEELMEENM---------TLEM-AQKQSMDESLHLGWELEQISRTSELSEAPQK 448
Query: 291 ASSQEV---AAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRY---QTKFRHLSKE-E 343
+ EV + LL L + Q L + L+ TV + S+ + + + LSK+ E
Sbjct: 449 SLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE 508
Query: 344 SLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVK 403
L E + K L + + LS +D+MKEK +L T++ +++ + +
Sbjct: 509 ILENEIVQEKQS----LQNCQNLS------KDLMKEKAQLEKTIETLRENSERQIKILEQ 558
Query: 404 ENEELHQ---ELNKSSAVTSE-EWRQLQTQAKLV---LEENKLLLEQLEIQQRKAK---D 453
ENE L+Q L + S +++E + ++ + K++ ++E L ++E ++R+ K +
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618
Query: 454 SHQERLQEVSKLTKQLMLLEAKTHGQEKELAENR---EQLEILRAKCQELKTHSDG-KIA 509
++E+ + +L +L LE + +K++ + E++E L + EL+ + K
Sbjct: 619 HYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKT 678
Query: 510 VEVHKSIVNELK------SQLQKEEEKERAEMEEL---MEKLTVLQAQKKSLLLEKNSLT 560
++ K++ +L+ SQL +E + R +E L K+ LQ + K L EK L
Sbjct: 679 LDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLK 738
Query: 561 EQNKALEAELERAQKI----------NRKSQKKIEVLKKQVEKAMGN----EMSAHQYLA 606
+ + L+A ++ +++ N++ QK +E K++++ EM
Sbjct: 739 KGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQK 798
Query: 607 NLVGL------AENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQ 660
NL L E + +E SL LE +K ++ K N RL + E ++
Sbjct: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKDK----KQLEKENKRLRQQAEIKDTTLEE 854
Query: 661 AALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQA 707
+K+G++ ++ + + + Y++ L ++ K+ +E++ +A
Sbjct: 855 NNVKIGNLE----KENKTLSKEIGIYKESCVRLKELEKENKELVKRA 897
Score = 78.6 bits (192), Expect = 2e-14
Identities = 124/563 (22%), Positives = 236/563 (41%), Gaps = 81/563 (14%)
Query: 234 EITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASS 293
E + + + L++EN LN SL +++ + ++K +EKE + L E+ K +S
Sbjct: 547 ENSERQIKILEQENEHLNQTVSSLR------QRSQISAEARVKDIEKENKILHESIKETS 600
Query: 294 QEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSK 353
+++ E + +++ E + K R + + HL KE L
Sbjct: 601 SKLSKIEF-----EKRQIKKELEHYKEKGERAE----ELENELHHLEKENEL-------- 643
Query: 354 GPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFR---MRVQEVVKENEELHQ 410
+ + ++K + A E E + N LK+ + F+ +++ + KEN +L +
Sbjct: 644 --LQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDE 701
Query: 411 ELNK------SSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQ---- 460
E + S S + QLQ + K + E + L + LE+ KA ERL+
Sbjct: 702 ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL--KASFKKTERLEVSYQ 759
Query: 461 ----EVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSI 516
E +L K L K E EL + + + L+ +ELK S +E
Sbjct: 760 GLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKS 819
Query: 517 VNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNS-----LTEQNKALEAELE 571
+ + SQL+K++++ E + L + QA+ K LE+N+ L ++NK L E+
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQ-----QAEIKDTTLEENNVKIGNLEKENKTLSKEI- 873
Query: 572 RAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLES 631
I ++S +++ L+K+ ++ + A + LV L E++ E+ + LE
Sbjct: 874 ---GIYKESCVRLKELEKENKELV---KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927
Query: 632 ----------EKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAG 681
K+ +L+ ++ R LE K++ K++ +I + E
Sbjct: 928 LTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSL----EIKEEKIAALEARLE 983
Query: 682 KTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDTLT 741
++ Y Q++R + +K E L Q + R ++ + E +N+ RE + T
Sbjct: 984 ESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE----DNKWERESQETTRE 1039
Query: 742 RTGVQDNPRALVAPSLNGVSQAD 764
V+D R + N QA+
Sbjct: 1040 LLKVKD--RLIEVERNNATLQAE 1060
Score = 68.2 bits (165), Expect = 3e-11
Identities = 118/494 (23%), Positives = 202/494 (40%), Gaps = 92/494 (18%)
Query: 293 SQEVAAPELLYLRKQAQELVDEND---------------------------------GLK 319
SQE P L + + L+DE D G+K
Sbjct: 182 SQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMK 241
Query: 320 MTVHR--LNVELSRYQTKFRHLSKE-ESLNIEGLPSKGPIPPWLLDIKYLSP----LLLA 372
T R L+VEL+ + K R L +E E + L K + +++K L LL
Sbjct: 242 RTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSD 301
Query: 373 YEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQ-ELNKSSAVTSEEWRQLQTQAK 431
+DEL+A ++ +R+ ++ EV + E LH E K+ +L+ +
Sbjct: 302 ARSARMYRDELDALREKAVRVDKLE-SEVSRYKERLHDIEFYKARV------EELKEDNQ 354
Query: 432 LVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLE 491
++LE +L +QLE + ++ H+ L K+ + L+AK H E E +R+++E
Sbjct: 355 VLLETKTMLEDQLEGTRARSDKLHE--------LEKENLQLKAKLHDMEMERDMDRKKIE 406
Query: 492 ILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKS 551
L + L+ + +H E+E++ + +A +KS
Sbjct: 407 ELMEENMTLEMAQKQSMDESLHLG-----------------WELEQISRTSELSEAPQKS 449
Query: 552 LLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEM------SAHQYL 605
L E N LT ++ L+ E+E N+ K +E L+ V+ GN +Q L
Sbjct: 450 LGHEVNELT-SSRLLKLEME-----NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRL 503
Query: 606 ANLVGLAEN-ITQERDSLM-C--LAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQA 661
+ V + EN I QE+ SL C L+K L EK L K I++ +R E ++K +++
Sbjct: 504 SKKVEILENEIVQEKQSLQNCQNLSKDLMKEK-AQLEKTIET-LRENS-ERQIKILEQEN 560
Query: 662 ALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVI 721
+S Q + +E + LH+ +K+ L + + R+++ ELE
Sbjct: 561 EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY 620
Query: 722 WESTFRENRRIREL 735
E R EL
Sbjct: 621 KEKGERAEELENEL 634
Score = 52.4 bits (124), Expect = 2e-06
Identities = 109/479 (22%), Positives = 200/479 (41%), Gaps = 71/479 (14%)
Query: 237 REKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKAS---- 292
RE + K + +NN + LT EL + KE L + ++ KL E++ S
Sbjct: 908 REDLVSEKLKTQQMNNDLEKLTHELEKIG-LNKERLLHDEQSTDDRYKLLESKLESTLKK 966
Query: 293 SQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPS 352
S E+ ++ L + +E + N L+ L Y+ + EE + P
Sbjct: 967 SLEIKEEKIAALEARLEESTNYNQQLRQ---ELKTVKKNYEA-LKQRQDEERMVQSSPPI 1022
Query: 353 KGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQE- 411
G W + + + LL +D + E + NATL+ E + + +++++ +N L +
Sbjct: 1023 SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI 1082
Query: 412 --LNKSSAVTSEEWRQLQTQ-AKLVLEENKLLLE---------QLEIQQRKAKDSHQERL 459
L + + E+ LQTQ AKL +E + L + QL IQQ ++ ++ +
Sbjct: 1083 LALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVI 1142
Query: 460 QEVSKLTKQLMLLEAKTHGQEKELAENRE--QLEILRAKCQELKT-HSDGKIAVEVHKSI 516
+E L K L K H ++ EL R+ + E L +K LK+ H + ++ +
Sbjct: 1143 KEREDL-KSLYDSLIKDH-EKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDR 1200
Query: 517 VNEL---KSQLQKEEEKERAEME-------------------------------ELMEKL 542
N+L K QL+ E+ + E E +L+++
Sbjct: 1201 YNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET 1260
Query: 543 TVLQAQKKSL-LLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSA 601
VLQ K+L L NS EQ + LEAE + ++ ++ L Q E + +
Sbjct: 1261 EVLQTDHKNLKSLLNNSKLEQTR-LEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL 1319
Query: 602 HQYLANLVGLAENITQERDSLMCLAKCLES------EKDGVLNKVIKSNIRLGKLEEKV 654
+ +L+ + + + +L L + +ES E+ ++K+ + + KLEEK+
Sbjct: 1320 EEENRHLLDQIQTLMLQNRTL--LEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1376
Score = 48.1 bits (113), Expect = 3e-05
Identities = 76/364 (20%), Positives = 160/364 (43%), Gaps = 71/364 (19%)
Query: 442 EQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKEL----AEN----------- 486
+ L ++ AK + QE+ + T+QL+ + + E EL EN
Sbjct: 247 QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR 306
Query: 487 --REQLEILRAKC-------QELKTHSDGKIAVEVHKSIVNEL----------KSQLQKE 527
R++L+ LR K E+ + + +E +K+ V EL K+ L+ +
Sbjct: 307 MYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQ 366
Query: 528 EEKERA---EMEELMEKLTVLQAQKKSLLLEKN-------SLTEQNKALEAELERA---- 573
E RA ++ EL ++ L+A+ + +E++ L E+N LE +++
Sbjct: 367 LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDES 426
Query: 574 -------QKINRKSQKKIEVLKKQVEKAMGNEMS--AHQYLANLVGLAENITQERDSLMC 624
++I+R S+ L + +K++G+E++ L L +++T+ + L
Sbjct: 427 LHLGWELEQISRTSE-----LSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRT 481
Query: 625 LAKCLESEKDGVLNKVIKSNIRLGKLEEKVKG---YKKQAALKLGDISHRLLEQQEDFAG 681
+E +L K+ K N RL K E ++ +KQ+ ++S L++++
Sbjct: 482 TVDSVEGNASKIL-KMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540
Query: 682 KTAQYRQEMRHLHQVLKDKQEVLDQ---ALQQNREMEGELEVIWESTFRENRRIRELLQD 738
R+ ++L+ + E L+Q +L+Q ++ E V + +EN+ + E +++
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARV--KDIEKENKILHESIKE 598
Query: 739 TLTR 742
T ++
Sbjct: 599 TSSK 602
Score = 42.0 bits (97), Expect = 0.002
Identities = 62/295 (21%), Positives = 121/295 (41%), Gaps = 53/295 (17%)
Query: 228 ARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGME-------K 280
A QR T +E+ L+ +N L N +L + ++ +L ++ +E K
Sbjct: 1084 ALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIK 1143
Query: 281 EKRKLKEAEKASSQEVAAPELLYLRKQAQ--ELVDENDGLKMTVHRLNVELSRYQTKFRH 338
E+ LK + ++ ELL+ R+ ++ L+ ++ LK L VE + ++
Sbjct: 1144 EREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ 1203
Query: 339 LSKEESLNIEGLPS--KGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNAT----LKE--- 389
L K++ +E L K LL+ K + Y+ + E D LN T LKE
Sbjct: 1204 LLKQKG-QLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEV 1262
Query: 390 -------------EMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWR------------ 424
++ + R++ + +E +Q+L+ +S + +
Sbjct: 1263 LQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEE 1322
Query: 425 ------QLQT---QAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLM 470
Q+QT Q + +LE+N + ++QR+ D E ++ KL +++M
Sbjct: 1323 NRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIM 1377
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 82.4 bits (202), Expect = 1e-15
Identities = 94/520 (18%), Positives = 234/520 (45%), Gaps = 52/520 (10%)
Query: 241 EALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPE 300
EA+ EE ++ + + ++ ++Q +++LQ ++KG + E +LKE E + ++ +
Sbjct: 1018 EAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEK 1077
Query: 301 LLYLRKQAQELVDENDGLKMTVH------RLNVELSRYQTKFRHLSKEESLNIEGLPSKG 354
+++ +EL ++N L + + R EL++ T ++ KE +E
Sbjct: 1078 ETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILE------ 1131
Query: 355 PIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELH-QELN 413
++ + + L E + EK+ + L+ ++ F+ +Q+ VK ++L+ +EL
Sbjct: 1132 ---TQKVECSHSAKL----EQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELK 1184
Query: 414 KSSAVTS-----EEWRQL----QTQAKLVLEENKLLLEQLEIQQRKA---KDSHQERLQE 461
+T ++ + L + + + +E + L E+L + K Q + ++
Sbjct: 1185 LKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEED 1244
Query: 462 VSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQEL-KTHSDGKIAVEVHKSIVNEL 520
+ L ++L + + +KE++ R++ ++LR K EL K + +++ + + +L
Sbjct: 1245 YADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQL 1304
Query: 521 KSQLQKEEEKERAEM-----EELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQK 575
K QL ++ +E + ++L K +++ + +L ++ + EQ++ LEA+LE ++
Sbjct: 1305 KEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVER 1364
Query: 576 INRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDG 635
+ + +K E K H+ +++G N+ E E + +
Sbjct: 1365 LATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQE-------SEQKYNA 1417
Query: 636 VLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQ 695
K ++ + L ++ + + + K + R +QQ + TAQ ++ L +
Sbjct: 1418 DRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQK 1477
Query: 696 VLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIREL 735
+++ +++ +E +L+ + S +++ I +L
Sbjct: 1478 WREERDQLV-------AALEIQLKALISSNVQKDNEIEQL 1510
Score = 57.4 bits (137), Expect = 5e-08
Identities = 87/383 (22%), Positives = 171/383 (44%), Gaps = 57/383 (14%)
Query: 389 EEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQ 448
E +R F + ++ +K +E ELNK + Q +L L E K L E+QQ
Sbjct: 845 EGLRAFLLTIENELKNEKEEKAELNKQI---------VHFQQELSLSEKKNLTLSKEVQQ 895
Query: 449 RKA------------KDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAK 496
++ K +QE+ +++ KL+ ++ E T + + N Q++++ K
Sbjct: 896 IQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEI---ETAT----RSITNNVSQIKLMHTK 948
Query: 497 CQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEK 556
EL+T + + +L S +E+ +++ L V + K+ + E
Sbjct: 949 IDELRTLDSVSQISNIDLLNLRDL-SNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEP 1007
Query: 557 NSLTEQNKALEAELERAQKINRKSQKK---IEVLKKQVEKAMGNEMSAHQYLANLVGLAE 613
N + ++EA E ++I + S KK IE L++Q+EK E+ ++ N + E
Sbjct: 1008 NRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQA-EVKGYKDENNRLKEKE 1066
Query: 614 -----NITQERDSLMCLAKCLESEK----DGVLNKVIKSNIRLGKLEEKVKGYKKQAALK 664
++ +E+++L+ K EK D + V++ L +L + V YK K
Sbjct: 1067 HKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYK----AK 1122
Query: 665 LGDISHRLLEQQEDFAGKTAQYRQEMRH-------LHQVLKDKQEVLDQALQQNREME-G 716
+ ++ +LE Q+ +A+ Q++ L + LK+ QE L +++ +++
Sbjct: 1123 IKEL-ETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVK 1181
Query: 717 ELEVIWESTFREN--RRIRELLQ 737
EL++ E T N + ++ LLQ
Sbjct: 1182 ELKLKEEITQLTNNLQDMKHLLQ 1204
Score = 53.5 bits (127), Expect = 7e-07
Identities = 72/374 (19%), Positives = 150/374 (40%), Gaps = 73/374 (19%)
Query: 227 RARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGME---KEKR 283
R + + E ++ + K+ N+ + + +T N ++ LQLK + E +E
Sbjct: 1159 RNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETE 1218
Query: 284 KLKEAEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEE 343
KLKE ASS L +L R + + L ++
Sbjct: 1219 KLKEELSASSAR--------------------------TQNLKADLQRKEEDYADLKEK- 1251
Query: 344 SLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVK 403
L D K +K+ + + +++E ++ R+++ E+ K
Sbjct: 1252 ----------------LTDAK----------KQIKQVQKEVSVMRDEDKLLRIKINELEK 1285
Query: 404 ENEELHQELNKSSAVTSEEWRQLQTQ-AKLVLEENKLLLEQLEIQQRKAKDSHQERLQEV 462
+ + QEL+ + QL Q + +++ + + L ++++ +D ++
Sbjct: 1286 KKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQE 1345
Query: 463 SKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSI-----V 517
+Q +LEAK E+ E LE + KC +L+T ++ + E + +
Sbjct: 1346 QTQVEQDQVLEAKLEEVERLATE----LEKWKEKCNDLETKNNQRSNKEHENNTDVLGKL 1401
Query: 518 NELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKIN 577
L+ +LQ+ E+K A+ ++ +E+ +L Q K +N ++ K + ER
Sbjct: 1402 TNLQDELQESEQKYNADRKKWLEEKMMLITQAKE---AENIRNKEMKKYAEDRERF---- 1454
Query: 578 RKSQKKIEVLKKQV 591
K Q ++E+L Q+
Sbjct: 1455 FKQQNEMEILTAQL 1468
Score = 46.2 bits (108), Expect = 1e-04
Identities = 85/405 (20%), Positives = 158/405 (39%), Gaps = 72/405 (17%)
Query: 379 EKDELNATLKEEMRMFRMRVQ----EVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVL 434
E +E A L+ + + + E++K EEL + N+S ++ E L+T K ++
Sbjct: 665 ETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQE----LETSNKKII 720
Query: 435 EENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQL-MLLEAKTHGQEKELAENREQLEIL 493
+N+ + E + I +K ++ + E L + + L N +++
Sbjct: 721 TQNQRIKELINIIDQK-----EDTINEFQNLKSHMENTFKCNDKADTSSLIINN---KLI 772
Query: 494 RAKCQELKTHSDGKIAVEVHKSIVNELK-----------------SQLQKEEEKERAEME 536
+ E+ S KI E + NEL+ ++ QK+ E+ R +
Sbjct: 773 CNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIA 832
Query: 537 ELMEKLTVLQAQKKS----LLLEKNSL---TEQNKALEAELERAQKINRKSQKKIEVLKK 589
E+ E + VLQ + LL +N L E+ L ++ Q+ S+KK L K
Sbjct: 833 EI-EDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSK 891
Query: 590 QVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGK 649
+V++ N A +A L ++ + +M L+ +E+ + N V + + K
Sbjct: 892 EVQQIQSNYDIA---IAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTK 948
Query: 650 LEE-----KVKGYKKQAALKLGDISH-----RLLEQQEDFAGKTAQYRQEMRHLHQVLKD 699
++E V L L D+S+ L Q D G + V K
Sbjct: 949 IDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGND----------YLVSKQ 998
Query: 700 KQEVLDQALQQNREMEGELEVIWE-------STFRENRRIRELLQ 737
+E Q + +E IWE ++ +++ +I EL Q
Sbjct: 999 VKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQ 1043
Score = 45.1 bits (105), Expect = 3e-04
Identities = 69/379 (18%), Positives = 156/379 (41%), Gaps = 62/379 (16%)
Query: 238 EKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVA 297
E + LKE+ D + + E++ M+ K L++K+ +EK+K + +
Sbjct: 1243 EDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQ---------- 1292
Query: 298 APELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIP 357
EL ++ Q+L ++ + ++ + +Y+ + L+ +E +
Sbjct: 1293 --ELDMKQRTIQQLKEQ-----LNNQKVEEAIQQYERACKDLNVKEKI------------ 1333
Query: 358 PWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVK---ENEELHQELNK 414
EDM +E T E+ ++ +++EV + E E+ ++ N
Sbjct: 1334 ---------------IEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCND 1378
Query: 415 SSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEA 474
++ + VL + L ++L+ ++K ++ L+E L Q E
Sbjct: 1379 LETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAEN 1438
Query: 475 KTHGQEKELAENRE-------QLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQK- 526
+ + K+ AE+RE ++EIL A+ E SD + E +V L+ QL+
Sbjct: 1439 IRNKEMKKYAEDRERFFKQQNEMEILTAQLTE--KDSDLQKWREERDQLVAALEIQLKAL 1496
Query: 527 -----EEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQ 581
+++ E +++ ++ + + ++ Q + ++ S + +K L + +I+R
Sbjct: 1497 ISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKI 1556
Query: 582 KKIEVLKKQVEKAMGNEMS 600
+ V+ E + N+ S
Sbjct: 1557 EDGSVVLDSCEVSTENDQS 1575
Score = 41.6 bits (96), Expect = 0.003
Identities = 69/364 (18%), Positives = 153/364 (42%), Gaps = 37/364 (10%)
Query: 400 EVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERL 459
E + E+E+L +EL + + E + L LEENK + E +RK D ++
Sbjct: 527 EDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEE--KRKLLDLIEDLK 584
Query: 460 QEV-----SKLTKQLMLLEAKTHGQEKELAENREQL-EILRAKCQELKTHSDGKIAVEVH 513
+++ KLT + + E T + A+ E L + + L+ +++ ++A+
Sbjct: 585 KKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAI--- 641
Query: 514 KSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERA 573
K + K + +E A + K+ +A L L+ N + + + EL +
Sbjct: 642 ------FKDLVGKCDTREEAAKDICATKVETEEA-TACLELKFNQIKAELAKTKGELIKT 694
Query: 574 QKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLE--- 630
++ +K + + + L +++E + ++ +Q + L+ + + + L +E
Sbjct: 695 KEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTF 754
Query: 631 --SEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGK-----T 683
++K + +I + + + E K K + + ++ L+Q E A K +
Sbjct: 755 KCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVS 814
Query: 684 AQYRQEMRHLHQVLKDKQEVLD-QALQQNRE--------MEGELEVIWESTFRENRRIRE 734
+ ++ + +V + E+ D + LQ+N E +E EL+ E N++I
Sbjct: 815 SAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVH 874
Query: 735 LLQD 738
Q+
Sbjct: 875 FQQE 878
Score = 33.1 bits (74), Expect = 1.0
Identities = 43/229 (18%), Positives = 99/229 (43%), Gaps = 33/229 (14%)
Query: 371 LAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQA 430
+++E+ K D + K+ + + ++ K EE+ QE + A ++++ Q
Sbjct: 568 ISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQE 627
Query: 431 KLVLEEN--------KLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKE 482
+ +LEEN K L+ + + ++ AKD ++ E + T L E
Sbjct: 628 REILEENAERRLAIFKDLVGKCDTREEAAKDICATKV-ETEEATACL------------E 674
Query: 483 LAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKL 542
L N+ + E+ + K + +KT + K S++ EL++ K+ + ++EL+
Sbjct: 675 LKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETS-NKKIITQNQRIKELI--- 730
Query: 543 TVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQV 591
+++ +K + + L++ +E K N K+ ++ ++
Sbjct: 731 --------NIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKL 771
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 82.0 bits (201), Expect = 2e-15
Identities = 120/559 (21%), Positives = 225/559 (40%), Gaps = 101/559 (18%)
Query: 223 DITGRARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEK 282
DI + Q+ E + +K + L+ E DL NQ T+++ ++EL++ K +E+ +
Sbjct: 762 DIENQRLQKTLENSNKKIQQLESELQDLEMENQ-------TLQKNLEELKISSKRLEQLE 814
Query: 283 RKLKEAEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKE 342
++ K E+ +SQ L K ++L EN L+ + L K +L KE
Sbjct: 815 KENKSLEQETSQ---------LEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE 865
Query: 343 ESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVV 402
K LS + Y++ EL KE ++ + ++ +V
Sbjct: 866 N--------------------KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLV 905
Query: 403 KENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEV 462
E+L E K+ + ++ + K+ L + +LL ++ + DS + L+
Sbjct: 906 TLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDE-----QSTDDSRYKLLESK 960
Query: 463 --SKLTKQLMLLEAKTHGQEKELAEN-------REQLEILRAKCQELKTHSDGKIAVEVH 513
S L K L + E K E L E+ R++L+ ++ + LK D + V+
Sbjct: 961 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS 1020
Query: 514 KSIVNE---------------LK------------SQLQKEEEKERAEMEELMEKLTVLQ 546
I E LK + LQ E++ + ++++L + LQ
Sbjct: 1021 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ 1080
Query: 547 AQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLA 606
AQ +L + SL EQN L+ + N K Q + L Q M +
Sbjct: 1081 AQILALQRQTVSLQEQNTTLQTQ-------NAKLQVENSTLNSQSTSLMNQNAQLLIQQS 1133
Query: 607 NLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLG 666
+L E++ +ER+ L L + +IK + +L L E+ + K G
Sbjct: 1134 SLENENESVIKEREDLKSL-----------YDSLIKDHEKLELLHERQASEYESLISKHG 1182
Query: 667 DI--SHRLLEQQ----EDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEV 720
+ +H+ LE + ED + + + ++ L ++LK +QE + + + + E +
Sbjct: 1183 TLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKK 1242
Query: 721 IWESTFRENRRIRELLQDT 739
+ R N +LL++T
Sbjct: 1243 LCGENDRLNHTYSQLLKET 1261
Score = 79.3 bits (194), Expect = 1e-14
Identities = 120/527 (22%), Positives = 242/527 (45%), Gaps = 81/527 (15%)
Query: 234 EITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKE---LQLKLKGMEKEKRKLKEAEK 290
++ R+K E L EENM TLE+ KQ+M E L +L+ + + + +K
Sbjct: 399 DMDRKKIEELMEENM---------TLEM-AQKQSMDESLHLGWELEQISRTSELSEAPQK 448
Query: 291 ASSQEV---AAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRY---QTKFRHLSKE-E 343
+ EV + LL L + Q L + L+ TV + S+ + + + LSK+ E
Sbjct: 449 SLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE 508
Query: 344 SLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVK 403
L E + K L + + LS +D+MKEK +L T++ +++ + +
Sbjct: 509 ILENEIVQEKQS----LQNCQNLS------KDLMKEKAQLEKTIETLRENSERQIKILEQ 558
Query: 404 ENEELHQ---ELNKSSAVTSE-EWRQLQTQAKLV---LEENKLLLEQLEIQQRKAK---D 453
ENE L+Q L + S +++E + ++ + K++ ++E L ++E ++R+ K +
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618
Query: 454 SHQERLQEVSKLTKQLMLLEAKTHGQEKELAENR---EQLEILRAKCQELKTHSDG-KIA 509
++E+ + +L +L LE + +K++ + E++E L + EL+ + K
Sbjct: 619 HYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKT 678
Query: 510 VEVHKSIVNELK------SQLQKEEEKERAEMEEL---MEKLTVLQAQKKSLLLEKNSLT 560
++ K++ +L+ SQL +E + R +E L K+ LQ + K L EK L
Sbjct: 679 LDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLK 738
Query: 561 EQNKALEAELERAQKI----------NRKSQKKIEVLKKQVEKAMGN----EMSAHQYLA 606
+ + L+A ++ +++ N++ QK +E K++++ EM
Sbjct: 739 KGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQK 798
Query: 607 NLVGL------AENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQ 660
NL L E + +E SL LE +K ++ K N RL + E ++
Sbjct: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKDK----KQLEKENKRLRQQAEIKDTTLEE 854
Query: 661 AALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQA 707
+K+G++ ++ + + + Y++ L ++ K+ +E++ +A
Sbjct: 855 NNVKIGNLE----KENKTLSKEIGIYKESCVRLKELEKENKELVKRA 897
Score = 75.9 bits (185), Expect = 1e-13
Identities = 128/565 (22%), Positives = 236/565 (41%), Gaps = 84/565 (14%)
Query: 234 EITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASS 293
E + + + L++EN LN SL +++ + ++K +EKE + L E+ K +S
Sbjct: 547 ENSERQIKILEQENEHLNQTVSSLR------QRSQISAEARVKDIEKENKILHESIKETS 600
Query: 294 QEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSK 353
+++ E + +++ E + K R + + HL KE L
Sbjct: 601 SKLSKIEF-----EKRQIKKELEHYKEKGERAE----ELENELHHLEKENEL-------- 643
Query: 354 GPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFR---MRVQEVVKENEELHQ 410
+ + ++K + A E E + N LK+ + F+ +++ + KEN +L +
Sbjct: 644 --LQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDE 701
Query: 411 ELNK------SSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQ---- 460
E + S S + QLQ + K + E + L + LE+ KA ERL+
Sbjct: 702 ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL--KASFKKTERLEVSYQ 759
Query: 461 ----EVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSI 516
E +L K L K E EL + + + L+ +ELK S +E
Sbjct: 760 GLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKS 819
Query: 517 VNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNS-----LTEQNKALEAELE 571
+ + SQL+K++++ E + L + QA+ K LE+N+ L ++NK L E+
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQ-----QAEIKDTTLEENNVKIGNLEKENKTLSKEI- 873
Query: 572 RAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLES 631
I ++S +++ L+K+ ++ + A + LV L E++ E+ + LE
Sbjct: 874 ---GIYKESCVRLKELEKENKELV---KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927
Query: 632 -----EKDGVLNK-------VIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDF 679
EK G LNK + R LE K++ K++ +I + E
Sbjct: 928 LTHELEKIG-LNKERLLHDEQSTDDSRYKLLESKLESTLKKSL----EIKEEKIAALEAR 982
Query: 680 AGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIRELLQDT 739
++ Y Q++R + +K E L Q + R ++ + E +N+ RE + T
Sbjct: 983 LEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE----DNKWERESQETT 1038
Query: 740 LTRTGVQDNPRALVAPSLNGVSQAD 764
V+D R + N QA+
Sbjct: 1039 RELLKVKD--RLIEVERNNATLQAE 1061
Score = 68.2 bits (165), Expect = 3e-11
Identities = 118/494 (23%), Positives = 202/494 (40%), Gaps = 92/494 (18%)
Query: 293 SQEVAAPELLYLRKQAQELVDEND---------------------------------GLK 319
SQE P L + + L+DE D G+K
Sbjct: 182 SQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMK 241
Query: 320 MTVHR--LNVELSRYQTKFRHLSKE-ESLNIEGLPSKGPIPPWLLDIKYLSP----LLLA 372
T R L+VEL+ + K R L +E E + L K + +++K L LL
Sbjct: 242 RTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSD 301
Query: 373 YEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQ-ELNKSSAVTSEEWRQLQTQAK 431
+DEL+A ++ +R+ ++ EV + E LH E K+ +L+ +
Sbjct: 302 ARSARMYRDELDALREKAVRVDKLE-SEVSRYKERLHDIEFYKARV------EELKEDNQ 354
Query: 432 LVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLE 491
++LE +L +QLE + ++ H+ L K+ + L+AK H E E +R+++E
Sbjct: 355 VLLETKTMLEDQLEGTRARSDKLHE--------LEKENLQLKAKLHDMEMERDMDRKKIE 406
Query: 492 ILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKS 551
L + L+ + +H E+E++ + +A +KS
Sbjct: 407 ELMEENMTLEMAQKQSMDESLHLG-----------------WELEQISRTSELSEAPQKS 449
Query: 552 LLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEM------SAHQYL 605
L E N LT ++ L+ E+E N+ K +E L+ V+ GN +Q L
Sbjct: 450 LGHEVNELT-SSRLLKLEME-----NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRL 503
Query: 606 ANLVGLAEN-ITQERDSLM-C--LAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQA 661
+ V + EN I QE+ SL C L+K L EK L K I++ +R E ++K +++
Sbjct: 504 SKKVEILENEIVQEKQSLQNCQNLSKDLMKEK-AQLEKTIET-LRENS-ERQIKILEQEN 560
Query: 662 ALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVI 721
+S Q + +E + LH+ +K+ L + + R+++ ELE
Sbjct: 561 EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY 620
Query: 722 WESTFRENRRIREL 735
E R EL
Sbjct: 621 KEKGERAEELENEL 634
Score = 53.9 bits (128), Expect = 6e-07
Identities = 107/479 (22%), Positives = 199/479 (41%), Gaps = 70/479 (14%)
Query: 237 REKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKAS---- 292
RE + K + +NN + LT EL + + L + + + KL E++ S
Sbjct: 908 REDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKK 967
Query: 293 SQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPS 352
S E+ ++ L + +E + N L+ L Y+ + EE + P
Sbjct: 968 SLEIKEEKIAALEARLEESTNYNQQLRQ---ELKTVKKNYEA-LKQRQDEERMVQSSPPI 1023
Query: 353 KGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQE- 411
G W + + + LL +D + E + NATL+ E + + +++++ +N L +
Sbjct: 1024 SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI 1083
Query: 412 --LNKSSAVTSEEWRQLQTQ-AKLVLEENKLLLE---------QLEIQQRKAKDSHQERL 459
L + + E+ LQTQ AKL +E + L + QL IQQ ++ ++ +
Sbjct: 1084 LALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVI 1143
Query: 460 QEVSKLTKQLMLLEAKTHGQEKELAENRE--QLEILRAKCQELKT-HSDGKIAVEVHKSI 516
+E L K L K H ++ EL R+ + E L +K LK+ H + ++ +
Sbjct: 1144 KEREDL-KSLYDSLIKDH-EKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDR 1201
Query: 517 VNEL---KSQLQKEEEKERAEME-------------------------------ELMEKL 542
N+L K QL+ E+ + E E +L+++
Sbjct: 1202 YNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET 1261
Query: 543 TVLQAQKKSL-LLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSA 601
VLQ K+L L NS EQ + LEAE + ++ ++ L Q E + +
Sbjct: 1262 EVLQTDHKNLKSLLNNSKLEQTR-LEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL 1320
Query: 602 HQYLANLVGLAENITQERDSLMCLAKCLES------EKDGVLNKVIKSNIRLGKLEEKV 654
+ +L+ + + + +L L + +ES E+ ++K+ + + KLEEK+
Sbjct: 1321 EEENRHLLDQIQTLMLQNRTL--LEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1377
Score = 48.1 bits (113), Expect = 3e-05
Identities = 76/364 (20%), Positives = 160/364 (43%), Gaps = 71/364 (19%)
Query: 442 EQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKEL----AEN----------- 486
+ L ++ AK + QE+ + T+QL+ + + E EL EN
Sbjct: 247 QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR 306
Query: 487 --REQLEILRAKC-------QELKTHSDGKIAVEVHKSIVNEL----------KSQLQKE 527
R++L+ LR K E+ + + +E +K+ V EL K+ L+ +
Sbjct: 307 MYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQ 366
Query: 528 EEKERA---EMEELMEKLTVLQAQKKSLLLEKN-------SLTEQNKALEAELERA---- 573
E RA ++ EL ++ L+A+ + +E++ L E+N LE +++
Sbjct: 367 LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDES 426
Query: 574 -------QKINRKSQKKIEVLKKQVEKAMGNEMS--AHQYLANLVGLAENITQERDSLMC 624
++I+R S+ L + +K++G+E++ L L +++T+ + L
Sbjct: 427 LHLGWELEQISRTSE-----LSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRT 481
Query: 625 LAKCLESEKDGVLNKVIKSNIRLGKLEEKVKG---YKKQAALKLGDISHRLLEQQEDFAG 681
+E +L K+ K N RL K E ++ +KQ+ ++S L++++
Sbjct: 482 TVDSVEGNASKIL-KMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540
Query: 682 KTAQYRQEMRHLHQVLKDKQEVLDQ---ALQQNREMEGELEVIWESTFRENRRIRELLQD 738
R+ ++L+ + E L+Q +L+Q ++ E V + +EN+ + E +++
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARV--KDIEKENKILHESIKE 598
Query: 739 TLTR 742
T ++
Sbjct: 599 TSSK 602
Score = 42.0 bits (97), Expect = 0.002
Identities = 62/295 (21%), Positives = 121/295 (41%), Gaps = 53/295 (17%)
Query: 228 ARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGME-------K 280
A QR T +E+ L+ +N L N +L + ++ +L ++ +E K
Sbjct: 1085 ALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIK 1144
Query: 281 EKRKLKEAEKASSQEVAAPELLYLRKQAQ--ELVDENDGLKMTVHRLNVELSRYQTKFRH 338
E+ LK + ++ ELL+ R+ ++ L+ ++ LK L VE + ++
Sbjct: 1145 EREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ 1204
Query: 339 LSKEESLNIEGLPS--KGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNAT----LKE--- 389
L K++ +E L K LL+ K + Y+ + E D LN T LKE
Sbjct: 1205 LLKQKG-QLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEV 1263
Query: 390 -------------EMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWR------------ 424
++ + R++ + +E +Q+L+ +S + +
Sbjct: 1264 LQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEE 1323
Query: 425 ------QLQT---QAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLM 470
Q+QT Q + +LE+N + ++QR+ D E ++ KL +++M
Sbjct: 1324 NRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIM 1378
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 81.6 bits (200), Expect = 3e-15
Identities = 118/546 (21%), Positives = 226/546 (41%), Gaps = 48/546 (8%)
Query: 196 QQKDGKHPVLNLKDEKPPLCEKPPPSPDITGRARQRYTEITREKFEALKEENMDLNNMNQ 255
QQ+ + +LN K PL P R + +T E LK+ DL
Sbjct: 255 QQRIDRLALLNEKQAASPL------EPKELEELRDKNESLTMRLHETLKQ-CQDLKTEKS 307
Query: 256 SLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPELLYLRKQAQELVDEN 315
+ ++N + + +L KL+ ++L++A ++E + +L KQAQ L E
Sbjct: 308 QMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQ-LEKEL 366
Query: 316 DGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLP-SKGPIPPWLLDIKYLSPLLLAYE 374
L + Q K L + S + P KG + L D+ L L
Sbjct: 367 SAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEV---LGDVLQLETL----- 418
Query: 375 DMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVL 434
K E ATL + RV+ + E + +L EE +QL + L
Sbjct: 419 -----KQEA-ATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLI-TDL 471
Query: 435 EENKLLLEQLEIQQRKAKDSHQERL-QEVSKLTKQLMLLEAKTHGQEKELAENREQLEIL 493
+ + L Q + + +A +H RL +V+ LT +L L A Q++ELA ++Q +
Sbjct: 472 QSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEK 531
Query: 494 RAK----CQELKTHSDG-KIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQ 548
+A+ Q+ + S G + VE S + + + QL++ EK+ A ++ ++L +
Sbjct: 532 QAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEE 591
Query: 549 KKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANL 608
+++ L E+++ +Q +ALE E K+E+L++Q++ A SA +
Sbjct: 592 REASLRERDAALKQLEALEKE----------KAAKLEILQQQLQVANEARDSAQTSVTQA 641
Query: 609 VGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDI 668
++++ + L + E+ +V + ++L + E++ K++ A + +
Sbjct: 642 QREKAELSRKVEELQACVETARQEQHEAQAQVAELELQL-RSEQQKATEKERVAQEKDQL 700
Query: 669 SHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRE 728
+L +E +E R L+++Q + E++ E + E RE
Sbjct: 701 QEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCIS-------ELKAETRSLVEQHKRE 753
Query: 729 NRRIRE 734
+ + E
Sbjct: 754 RKELEE 759
Score = 72.0 bits (175), Expect = 2e-12
Identities = 107/459 (23%), Positives = 197/459 (42%), Gaps = 52/459 (11%)
Query: 242 ALKEENMDLNNMNQSLTLELNTMKQAMKELQLKL-----------KGMEKEKRKLKEAEK 290
+L E LN Q EL +KQ KE Q +L +G+ + +L + K
Sbjct: 502 SLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLK 561
Query: 291 ASSQ---EVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNI 347
Q EVA + + AQ+L + + ++ + L + + L KE++ +
Sbjct: 562 QKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEA----LEKEKAAKL 617
Query: 348 EGLPSKGPIPPWLLDIKYLSPLLLAYE--DMMKEKDELNA---TLKEEMRMFRMRVQEVV 402
E L + + D S E ++ ++ +EL A T ++E + +V E+
Sbjct: 618 EILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELE 677
Query: 403 KENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEV 462
+ Q+ + V E+ QLQ Q + + E K+ LE ++R+A D+ +E+ + +
Sbjct: 678 LQLRSEQQKATEKERVAQEK-DQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCI 736
Query: 463 SKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKS 522
S+L + L + + KEL E R + L A+ Q+L E H
Sbjct: 737 SELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLG---------EAH--------- 778
Query: 523 QLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQK 582
Q E E R E+ E M +++ + L+ E + E+ + +++ E AQ Q+
Sbjct: 779 --QAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYE--DSQQEEAQ-YGAMFQE 833
Query: 583 KIEVLKKQVEKAMGNEMSAHQYLANLVGLAE-NITQERDSLMCLAKCLESEKDGVLNKVI 641
++ LK++ EKA A + +A + +E I+++++ L L L V K +
Sbjct: 834 QLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEV 893
Query: 642 KSN---IRLGKLEEKVKGYKKQAALKLGDISHRLLEQQE 677
++ L L+EK+ K+ A +L + + EQQE
Sbjct: 894 RAQKLADDLSTLQEKMAATSKEVA-RLETLVRKAGEQQE 931
Score = 72.0 bits (175), Expect = 2e-12
Identities = 93/401 (23%), Positives = 174/401 (43%), Gaps = 44/401 (10%)
Query: 226 GRARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKL 285
G+ + + E +K +AL ++ + Q+L EL K ++LQ + EK R+
Sbjct: 1326 GQELKAWQEKFFQKEQALSTLQLE-HTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREE 1384
Query: 286 KEAEKASSQEVAAPELLYLRKQAQELVDENDGL---KMTVHRLNVELSRYQTKFRHLSKE 342
E K ++ + A ELL +++ EL+ + + T +L E + Y + L K
Sbjct: 1385 LEQSKQAAGGLRA-ELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKA 1443
Query: 343 ESLNIE---GLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQ 399
L E GL + + L+++ L A E ++E + A + + + Q
Sbjct: 1444 HGLLAEENRGLGERANLGRQFLEVE----LDQAREKYVQELAAVRADAETRLAEVQREAQ 1499
Query: 400 EVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQR---------- 449
+E E + + + EE ++ Q + + + + +EQLE+ QR
Sbjct: 1500 STARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQ----VEQLEVFQREQTKQVEELS 1555
Query: 450 -KAKDSHQERLQEVSKL----------TKQLMLLEAKTHGQEKELAENREQLEILRAKCQ 498
K DS Q + KL ++ L+A+ + + +L++ + E + + +
Sbjct: 1556 KKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQME 1615
Query: 499 ELKTHSDGKIAVEVHKSIVNELKS--QLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEK 556
+ KTH D K + ++ + +L+S QLQKE ++ RAE E L +L + K
Sbjct: 1616 KAKTHYDAK--KQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTC 1673
Query: 557 NSLTEQNKALEAELERAQKINR---KSQKKIEVLKKQVEKA 594
LT Q ++LEA++ A + R K Q + LK + +A
Sbjct: 1674 RHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQA 1714
Score = 70.5 bits (171), Expect = 6e-12
Identities = 124/571 (21%), Positives = 226/571 (39%), Gaps = 77/571 (13%)
Query: 233 TEITREKFEALKEENMDLNNMNQSL---------TLELNTMKQAMKELQLKLKGMEKEKR 283
TE T K EAL+ E L Q +LE +A ++ L+ + E++
Sbjct: 1115 TEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEK 1174
Query: 284 KLKEAEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEE 343
+ S+ A EL R + Q+ D K V R E R + L +E
Sbjct: 1175 AQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEV 1234
Query: 344 S-LNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDEL------------------N 384
S LN + L +G + K L L++A + ++ +E +
Sbjct: 1235 SILNRQVLEKEG-------ESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERS 1287
Query: 385 ATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQT-QAKLVLEENKLLLEQ 443
+ L+EE++ R ++ +E L QEL + E ++L+ Q K +E L Q
Sbjct: 1288 SALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQ 1347
Query: 444 LEIQQRKAKDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQ------LEILRAKC 497
LE +A S L L +QL +A + +E E +Q E+LRA+
Sbjct: 1348 LEHTSTQALVS---ELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQ- 1403
Query: 498 QELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKN 557
+EL G++ K E +Q + E+ AE +++K L A++ L E+
Sbjct: 1404 REL-----GELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERA 1458
Query: 558 SLTEQNKALEAELERAQ-------------------KINRKSQKKIEVLKKQVEKAMGNE 598
+L Q LE EL++A+ ++ R++Q L+ K G +
Sbjct: 1459 NLGRQ--FLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAK 1516
Query: 599 MSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYK 658
+ + + +T + + L + + + + K+ S+ ++K+K +
Sbjct: 1517 VKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQ 1576
Query: 659 KQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGEL 718
Q + + RL Q + + +Q Q H ++ + D QQN+E++ +L
Sbjct: 1577 AQGGESQQE-AQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQL 1635
Query: 719 EVIWESTFRENRRIR---ELLQDTLTRTGVQ 746
+ E +EN+ +R E L L + G++
Sbjct: 1636 RSL-EQLQKENKELRAEAERLGHELQQAGLK 1665
Score = 63.5 bits (153), Expect = 7e-10
Identities = 108/561 (19%), Positives = 223/561 (39%), Gaps = 74/561 (13%)
Query: 234 EITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKL---KGMEKEKRKLKEAEK 290
E R +AL+E+ ++ + + K+ KEL+ + KG+E ++L EA +
Sbjct: 720 EEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQ 779
Query: 291 ASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEES-----L 345
A ++ LR++ E + + +L E++ ++ ++ +EE+
Sbjct: 780 AETE--------VLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMF 831
Query: 346 NIEGLPSKGPIPPWLLDIKYLSPLLLAYED--------MMKEKDELNATLKEEMRMFRMR 397
+ + K +++ + E E EL+A L ++ + +
Sbjct: 832 QEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEK 891
Query: 398 VQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQE 457
K ++L L + A TS+E +L+T + E+ + +L + +A D E
Sbjct: 892 EVRAQKLADDL-STLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPE 950
Query: 458 RLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRA-------KCQELKTHSDGKIA- 509
L+E + +Q +A E+E + +LE LRA + QE + + ++A
Sbjct: 951 WLEE--QQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVAR 1008
Query: 510 -----------VEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNS 558
+ + K+ EL+ +LQ ++R E L E L +K+ E
Sbjct: 1009 LTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAK 1068
Query: 559 LTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSA-------------HQYL 605
L A ELE ++ + Q K ++ KK+ E A G+ +
Sbjct: 1069 LRGLEAAQIKELEELRQTVK--QLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALR 1126
Query: 606 ANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVK---------- 655
A + L + ++++ L + LE+E+ + G+LEEK +
Sbjct: 1127 AEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALA 1186
Query: 656 -GYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREM 714
++ AA + H + ++++ + A+ RQE + ++ +E + +Q E
Sbjct: 1187 SAQRELAAFRTKVQDHS--KAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEK 1244
Query: 715 EGELEVIWESTFRENRRIREL 735
EGE + + E+ + ++L
Sbjct: 1245 EGESKELKRLVMAESEKSQKL 1265
Score = 45.8 bits (107), Expect = 2e-04
Identities = 78/394 (19%), Positives = 153/394 (38%), Gaps = 54/394 (13%)
Query: 369 LLLAYEDMMKEK-----DELNATLKEEMRM---FRMRVQEVVKENEELHQELNKS----- 415
+LL Y M K ++ ++ E+ + F + ++ + NE+L L K+
Sbjct: 100 MLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLNEDLENFLQKAPVPST 159
Query: 416 -SAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQ--EVSKLTKQLMLL 472
S+ EE QAK + LE+Q+ + S L S + L
Sbjct: 160 CSSTFPEELSPPSHQAKREIRF-------LELQKVASSSSGNNFLSGSPASPMGDILQTP 212
Query: 473 EAKTHGQEKELAE---NREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEE 529
+ + +K+LA+ NR++LE+ A+ ++L T D +IA+ + L ++ Q
Sbjct: 213 QFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASP 272
Query: 530 KERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKK 589
E E+EEL +K L + L + L + ++ ++ + + N K+
Sbjct: 273 LEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFAS 332
Query: 590 QVEKAMG--NEMSAHQYLANLVGLAENITQERDSLMCL--AKCLESEKDGVLNKVIKSNI 645
+++ NE++ A L + E++ L KCLE + + + K+ +
Sbjct: 333 HLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEE 392
Query: 646 RLGKLEEKVKGYK-------------KQAALKLGDISHRLL-----------EQQEDFAG 681
L +L++ K KQ A L + +L +Q+
Sbjct: 393 HLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLA 452
Query: 682 KTAQYRQEMRHLHQVLKDKQEVLDQALQQNREME 715
+ + +E + L ++ D Q + Q E+E
Sbjct: 453 ERGHFEEEKQQLSSLITDLQSSISNLSQAKEELE 486
>gi|9910266 kinesin family member 15 [Homo sapiens]
Length = 1388
Score = 81.6 bits (200), Expect = 3e-15
Identities = 111/514 (21%), Positives = 211/514 (41%), Gaps = 45/514 (8%)
Query: 234 EITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEA----- 288
E+ + FEA+ EE + +L +L+ + +LQ + +E +++E
Sbjct: 706 EMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSER 765
Query: 289 -EKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNV-------ELSRYQTKFRHLS 340
+ QE +L L KQ QE +ND LK VH L V ELS + ++
Sbjct: 766 IDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFK 825
Query: 341 KEESLNIEGLPSKGPIPPWLLDIKYL--SPLLLAYEDMMKEKDELNATLKEEMRMFRMRV 398
+ L + LD L LL + + D L +K E+ +
Sbjct: 826 TNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNL 885
Query: 399 QEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEE-----NKLLLEQLE-IQQRKAK 452
Q KENE L +LN + E ++ + L EE +K +L+ LE ++Q K K
Sbjct: 886 QNFKKENETLKSDLNNLMELLEAE-KERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQK 944
Query: 453 DSH--QERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAV 510
++ ++++ +V KL + L+ E EK +++ + L + QEL+T +V
Sbjct: 945 ETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRT------SV 998
Query: 511 EVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAEL 570
++ LK +L+ K + + + E +++ Q+ +L K +L + + + E
Sbjct: 999 CEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLRLRILSEDIER 1058
Query: 571 ERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLE 630
+ + + +++ +L + +K G SA E +T++ + L L
Sbjct: 1059 DMLCEDLAHATEQLNMLTEASKKHSGLLQSAQ----------EELTKKEALIQELQHKLN 1108
Query: 631 SEKDGVLNKVIKSNIRLGKLEEKVKG-----YKKQAALKLGDISHRLLEQQEDFAGKTAQ 685
+K+ V K + N ++ +LE + + +LLE QE
Sbjct: 1109 QKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRA 1168
Query: 686 YRQEMRHLHQVLKDKQEVLDQALQQNREMEGELE 719
+ + HL L + +EV + + + +E E+E
Sbjct: 1169 SKTSLEHLVTKLNEDREVKNAEILRMKEQLREME 1202
Score = 54.7 bits (130), Expect = 3e-07
Identities = 112/493 (22%), Positives = 187/493 (37%), Gaps = 97/493 (19%)
Query: 238 EKFEALKEENMDLN--------NMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAE 289
E EA KE N L+ N ++ + L ++Q ++ K + + +KL+E+
Sbjct: 904 ELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESL 963
Query: 290 KASSQEVAAPE---------LLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRH-- 338
A+ + +++ E + L Q QEL T+ L EL K+
Sbjct: 964 LATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSAL 1023
Query: 339 LSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRV 398
+ +EES L K + +LD+K L + ED+ E+D L L M
Sbjct: 1024 VDREES---RVLIKKQEVD--ILDLKETLRLRILSEDI--ERDMLCEDLAHATEQLNMLT 1076
Query: 399 QEVVKEN---EELHQELNKSSAVTSEEWRQLQTQAKLVLEENK----LLLEQLEIQQRKA 451
+ K + + +EL K A+ E +L Q K +E+ K + QLE A
Sbjct: 1077 EASKKHSGLLQSAQEELTKKEALIQELQHKLN-QKKEEVEQKKNEYNFKMRQLEHVMDSA 1135
Query: 452 KDSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQ---LEILRAKCQELKTHSDGKI 508
+ Q T LLE QE+E+ + R LE L K E +
Sbjct: 1136 AEDPQSPKTPPHFQTHLAKLLET----QEQEIEDGRASKTSLEHLVTKLNEDR------- 1184
Query: 509 AVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLL--------------- 553
EV + + +K QL +E E R E ++L+EK +LQ Q +
Sbjct: 1185 --EVKNAEILRMKEQL-REMENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQ 1241
Query: 554 ------------LEKNSLTEQNKALEAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSA 601
L K+ + E+ ++A+LE Q + + + +VE+ E A
Sbjct: 1242 LKNEQEESIKERLAKSKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKA 1301
Query: 602 HQ-------YLANLVGLAENITQERDSLMCLAKCLESEKDGVLN------------KVIK 642
Q L + E +QE + L +CL E ++ ++ K
Sbjct: 1302 FQEKEQLRSKLEEMYEERERTSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKK 1361
Query: 643 SNIRLGKLEEKVK 655
N+RL + EK++
Sbjct: 1362 ENVRLAEETEKLR 1374
Score = 53.5 bits (127), Expect = 7e-07
Identities = 103/518 (19%), Positives = 208/518 (40%), Gaps = 87/518 (16%)
Query: 213 PLCEKPPPSPDITGRARQRYTEITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQ 272
P +K P T + + + +I E + K+E + + + LEL + Q++++
Sbjct: 569 PKAQKEPCLFANTEKLKAQLLQIQTELNNS-KQEYEEFKELTRKRQLELESELQSLQKAN 627
Query: 273 LKLKGMEKEKRKLKEAEKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRY 332
L L+ L EA KA ++ E+ L K +H +++
Sbjct: 628 LNLE-------NLLEATKACKRQ----EVSQLNK---------------IHAETLKIITT 661
Query: 333 QTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMR 392
TK L P+P ++ L ++ + D LN + EM
Sbjct: 662 PTKAYQLHSR------------PVPKLSPEMGSFGSLYTQNSSIL-DNDILNEPVPPEM- 707
Query: 393 MFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAK 452
NE+ + +++ E+ L QAKL EE+K L++QQ K
Sbjct: 708 ------------NEQAFEAISEELRTVQEQMSAL--QAKLDEEEHK----NLKLQQHVDK 749
Query: 453 -DSHQERLQEVSK-----LTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDG 506
+ H ++QE+ TKQ L ++ + EK+L E + + + L+++ +L
Sbjct: 750 LEHHSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDL------ 803
Query: 507 KIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKAL 566
++ + ++ +K + + + E +L E+ +Q Q +L LE L E L
Sbjct: 804 RVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACL 863
Query: 567 EAELERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCLA 626
+ + Q+I + +I+ L + ++ + L NL+ L E +ER++ + L
Sbjct: 864 QDSYDNLQEI---MKFEIDQLSRNLQNFKKENETLKSDLNNLMELLE-AEKERNNKLSLQ 919
Query: 627 KCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRL---------LEQQE 677
E +K+ +++K + + ++K +Q K+ + L LE+
Sbjct: 920 --FEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSR 977
Query: 678 DFAGK-TAQYRQEMRHLHQVLKDKQEVLDQALQQNREM 714
D K A +++ L + +K E +D Q+ +++
Sbjct: 978 DSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDI 1015
Score = 47.8 bits (112), Expect = 4e-05
Identities = 74/308 (24%), Positives = 134/308 (43%), Gaps = 55/308 (17%)
Query: 411 ELNKSSAVTSEEWR----QLQTQAKLVLEENKLLLE-----QLEIQQRKAKDSHQERLQE 461
+L K+ AV +E+ + QLQ + K + E+ L + + + K K ++ E QE
Sbjct: 361 KLIKNKAVVNEDTQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQE 420
Query: 462 VSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELK 521
ML K+ ++K L E QLE L K + K K+ V+ + + L+
Sbjct: 421 A-------MLFFKKSEQEKKSLIEKVTQLEDLTLKKE--KFIQSNKMIVKFREDQIIRLE 471
Query: 522 SQLQKE-------EEKERAEMEELMEKLTVLQAQKK------SLLLEKNSLTEQNKALEA 568
+L KE EE++R + EL ++ L+ Q + +E +SL E+N+ L
Sbjct: 472 -KLHKESRGGFLPEEQDRL-LSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRL 529
Query: 569 --ELERAQKINRKSQKKIEVLKKQV---EKAMGNEM--------------SAHQYLANLV 609
++RAQ+++ ++ K+E ++ EK+ N+ + + A L+
Sbjct: 530 LEPVKRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLL 589
Query: 610 GLA---ENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLG 666
+ N QE + L + + E + L + K+N+ L L E K K+Q +L
Sbjct: 590 QIQTELNNSKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQLN 649
Query: 667 DISHRLLE 674
I L+
Sbjct: 650 KIHAETLK 657
Score = 45.1 bits (105), Expect = 3e-04
Identities = 80/394 (20%), Positives = 165/394 (41%), Gaps = 76/394 (19%)
Query: 235 ITREKFEAL-KEENMDLNNMNQSLTLEL-----------NTMKQAMKELQLKLKGMEKEK 282
+ RE+ L K++ +D+ ++ ++L L + + A ++L + + +K
Sbjct: 1024 VDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHS 1083
Query: 283 RKLKEA-EKASSQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSK 341
L+ A E+ + +E EL + Q +E V++ + Y K R L
Sbjct: 1084 GLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKK-------------NEYNFKMRQLEH 1130
Query: 342 EESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEV 401
E P PP +L+ LL E +++ +L E + ++
Sbjct: 1131 VMDSAAED-PQSPKTPPHFQT--HLAKLLETQEQEIEDGRASKTSL--EHLVTKLNEDRE 1185
Query: 402 VKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQ----- 456
VK E L + E L+ +++ ++E+N LL QL+ +R+ ++S Q
Sbjct: 1186 VKNAEILRMKEQL------REMENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDN 1239
Query: 457 ------------ERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHS 504
ERL + SK+ ++++ ++A +E + A +++E LR + +T +
Sbjct: 1240 QQLKNEQEESIKERLAK-SKIVEEMLKMKADL--EEVQSALYNKEMECLRMTDEVERTQT 1296
Query: 505 DGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNK 564
L+S+ +E+E+ R+++EE+ E+ + + L + L E+N
Sbjct: 1297 ---------------LESKAFQEKEQLRSKLEEMYEERERTSQEMEMLRKQVECLAEEN- 1340
Query: 565 ALEAELERAQKINRKSQKKIEVLKKQVEKAMGNE 598
+L Q +++K Q + + K+ V A E
Sbjct: 1341 ---GKLVGHQNLHQKIQYVVRLKKENVRLAEETE 1371
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 81.3 bits (199), Expect = 3e-15
Identities = 112/529 (21%), Positives = 238/529 (44%), Gaps = 60/529 (11%)
Query: 230 QRYTEITREKFEALKEENMDLNN-------MNQSLTLELNTMKQAMKELQLKLKGMEKEK 282
Q+ +I + E+N+ L + M Q T+ ++ +L+ ++ +E+E
Sbjct: 887 QKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQEL 946
Query: 283 RKLKE--AEKASSQEV----AAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKF 336
+K +E AEK E AA E R++ EL +K+ + + ELS+ + +
Sbjct: 947 QKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEI 1006
Query: 337 RHLSKE---ESLNIEGLP-----SKGPIPPWLLDIKYLSPLLLAYEDMMKEKDELNATLK 388
HL ++ +++++ L +K + +K L L + E + E + L+
Sbjct: 1007 MHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLE 1066
Query: 389 EEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQT------QAKLVLEENKLLLE 442
E++ ++ +++ +EL L K+ E++ ++ + K+ +E+ K L
Sbjct: 1067 TELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELL 1126
Query: 443 QL---------EIQQRKAKDSHQERL--QEVSKLTKQLMLLEAKTHGQEKELAENREQLE 491
++ E++QR A+ +H + + ++ ++++ LE E EL E +Q+E
Sbjct: 1127 EMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIE 1186
Query: 492 ILRAKCQELKTHSDGKIAVEV-HKSIVNELKSQLQKEEEKERAEMEELM---EKLTVLQA 547
L K Q K K + + ++ +++LK ++++ +++ + EME +M E+ Q
Sbjct: 1187 SLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMK-EMESVMKEQEQYIATQY 1245
Query: 548 QKKSLLLEKNSLT-EQNKALEAELERAQKINRKSQKKIEVLKKQVE--KAMGNEMSAH-Q 603
++ L ++ LT EQ + EL A+ ++Q++IE L ++E K + E AH
Sbjct: 1246 KEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGN 1305
Query: 604 YLANLVGLAENITQERDSLMC-----LAKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYK 658
+LA +G ++ ++ M L+ +ES K+ ++I K + K
Sbjct: 1306 HLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQK 1365
Query: 659 KQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQA 707
+L EQ E + + + + +LHQ ++D+ EV++ A
Sbjct: 1366 SSV--------QQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAA 1406
Score = 80.1 bits (196), Expect = 7e-15
Identities = 131/553 (23%), Positives = 243/553 (43%), Gaps = 79/553 (14%)
Query: 234 EITREKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLK-EAEKAS 292
EI +EK LKEEN NN + L + A+K ++ + E + LK E+E +
Sbjct: 417 EILKEKLRQLKEEN---NNGKEKLRI------MAVKNSEVMAQLTESRQSILKLESELEN 467
Query: 293 SQEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPS 352
E+ + L++EN LK+ V N L Q + S+ E ++E + S
Sbjct: 468 KDEILRDKF--------SLMNENRELKVRVAAQNERLDLCQQEIES-SRVELRSLEKIIS 518
Query: 353 KGPIPPWLLDIK-YLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENE--ELH 409
+ P+ L K YLS ++ KE + ++ + +R++ +KE E +LH
Sbjct: 519 QLPLKRELFGFKSYLSKYQMS-SFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLH 577
Query: 410 QELN----KSSAVTSEEWRQLQTQAKLVLEENKL----LLEQLEIQQRKAKDSHQERLQE 461
L S +T + ++ + L E KL + E ++ Q + + E+ ++
Sbjct: 578 ANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQ 637
Query: 462 -----VSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSI 516
+ +L +L+ +EA+ + +A Q ++++ + E K + K+ E+ K
Sbjct: 638 RLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLE-KASNSSKLESEMTKKC 696
Query: 517 VNELKSQLQKEEE--------KERAEME-ELMEKLTVLQAQKKSLLLEKNSLTEQNKALE 567
L + Q EE+ + AE+E ELMEK +K LE N TE K
Sbjct: 697 SQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEK------NEKIRSLETNINTEHEKICL 750
Query: 568 AELERAQKI----NRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLM 623
A E+A+KI +++ +K+IE L+ Q+EK + + + L ++I ++ L
Sbjct: 751 A-FEKAKKIHLEQHKEMEKQIERLEAQLEK---KDQQFKEQEKTMSMLQQDIICKQHHLE 806
Query: 624 CLAKCLESEK--------------DGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDIS 669
L + L K + N+V + I++ +L+ ++ K++ L L
Sbjct: 807 SLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHL---- 862
Query: 670 HRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFREN 729
++L +E F + + +E+ L + LK K L + +QN ++ L+ + +E
Sbjct: 863 NQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQET 922
Query: 730 RRIRELLQDTLTR 742
R E L+DT T+
Sbjct: 923 IRNGE-LEDTQTK 934
Score = 70.1 bits (170), Expect = 8e-12
Identities = 108/538 (20%), Positives = 226/538 (42%), Gaps = 72/538 (13%)
Query: 247 NMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAAPELLYLRK 306
N+ N ++QSL + N +++ K L+ + ++ ++ E+ K +Q + K
Sbjct: 579 NLTANQLSQSL-ITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQY---EK 634
Query: 307 QAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPP-------- 358
+ Q LV + L+ + ++ E S + H + + L E L K
Sbjct: 635 ERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTK 694
Query: 359 ---WLLDI-KYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNK 414
LL + K L ++AY + + EL L E+ R + E+E++ K
Sbjct: 695 KCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEK 754
Query: 415 SSAVTSEEWRQLQTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQEVSKLTKQLMLLEA 474
+ + E+ ++++ Q +E+LE Q K +E+ + +S L + ++ +
Sbjct: 755 AKKIHLEQHKEMEKQ-----------IERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQH 803
Query: 475 KTHGQEKELAENREQLEILRAKCQELKTHSDGKIAVEVHKSIVNELKSQL---------- 524
++ L E++ +++ K E +++ E K V +L S L
Sbjct: 804 HLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIK--VRQLDSALEICKEELVLH 861
Query: 525 --QKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSL---TEQNKALEAELERAQKI--- 576
Q E KE+ E ++L +K + +K L ++ +SL +EQN L+ L++ Q++
Sbjct: 862 LNQLEGNKEKFE-KQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQ 920
Query: 577 -----------NRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVGLAENITQERDSLMCL 625
K +K++ L+++++K S+ + L + E+ E D
Sbjct: 921 ETIRNGELEDTQTKLEKQVSKLEQELQK---QRESSAEKLRKMEEKCESAAHEADLKRQK 977
Query: 626 AKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQA---ALKLGDISHRLLEQQEDFAGK 682
L V ++ + L K+E+++ K+ A+ L + L + + + K
Sbjct: 978 VIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKK 1037
Query: 683 TAQYRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVI---WESTFRENRRIRELLQ 737
T ++ L ++ + L +ALQ+ +E EL+ +ST R+ + +R++LQ
Sbjct: 1038 T----NAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQ 1091
Score = 66.6 bits (161), Expect = 8e-11
Identities = 104/530 (19%), Positives = 236/530 (44%), Gaps = 60/530 (11%)
Query: 238 EKFEALKEENMDLNNMNQSLTL--------ELNTMKQAMKELQLKLKGMEKEKRKLKEAE 289
EK E ++ ++N ++ + L L K+ K+++ +EK+ ++ KE E
Sbjct: 729 EKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQE 788
Query: 290 KASS---QEVAAPELLYLRKQAQELVDENDGLKMTVHRLNVELSRYQTKFRHLSKEESLN 346
K S Q++ + + + L+ E+ G + + N++ ++ EE++
Sbjct: 789 KTMSMLQQDIICKQ--HHLESLDRLLTESKG---EMKKENMKKDEALKALQNQVSEETIK 843
Query: 347 IEGLPSKGPI--PPWLLDIKYLSPLLLAYEDMMKEKDELNATLKEEMRMFRMRVQEVVKE 404
+ L S I +L + L +E +K+K E L++E+++ +QE ++
Sbjct: 844 VRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQ 903
Query: 405 NEELHQELNKSSAVTSEEWRQL----QTQAKLVLEENKLLLEQLEIQQRKAKDSHQERLQ 460
N L L + + +E + TQ KL + +KL E + +K ++S E+L+
Sbjct: 904 NVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKL-----EQELQKQRESSAEKLR 958
Query: 461 EVSK----------LTKQLMLLEAKTHGQEK-ELAENREQLEILRAKCQELKTHSDGKIA 509
++ + L +Q ++ T Q K E+ + +E+L + + LK + K
Sbjct: 959 KMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKA- 1017
Query: 510 VEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQNKALEAE 569
+H S ++ + Q + E EK+ ++EL EKL + S E ++ + LE E
Sbjct: 1018 --MHLSQLDMILDQTKTELEKKTNAVKEL-EKL------QHSTETELTEALQKREVLETE 1068
Query: 570 LERAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQYLANLVG-LAE---NITQERDSLMCL 625
L+ A + + ++++ L+ ++KA + + + +L L E I ++ L+ +
Sbjct: 1069 LQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEM 1128
Query: 626 AKCLESEKDGVLNKVIKSNIRLGKLEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQ 685
+ L+ E++ L + L + +G +Q +KL + + ++ +
Sbjct: 1129 DQALK-ERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIES 1187
Query: 686 YRQEMRHLHQVLKDKQEVLDQALQQNREMEGELEVIWESTFRENRRIREL 735
++++ + L++K+ ++ Q Q+ +++ E+E R +R++E+
Sbjct: 1188 LNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIE-------RTQQRMKEM 1230
Score = 62.8 bits (151), Expect = 1e-09
Identities = 95/401 (23%), Positives = 186/401 (46%), Gaps = 49/401 (12%)
Query: 223 DITGRARQRYTEIT--REKFEALKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEK 280
++TG ARQ E+ +E+ +++E M L ++ + L+ + + + + +L EK
Sbjct: 980 ELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTEL---EK 1036
Query: 281 EKRKLKEAEKAS-SQEVAAPELLYLRKQAQ-ELVDENDGLKMTVHRLNVELSRYQTKFRH 338
+ +KE EK S E E L R+ + EL + + LK T+ +L EL K +
Sbjct: 1037 KTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQ-ELRDVLQKAQL 1095
Query: 339 LSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAYEDMMKEKD-----------ELNATL 387
+E+ I+ L ++ + ++I+ LL + +KE++ L+ T+
Sbjct: 1096 SLEEKYTTIKDLTAE--LRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTI 1153
Query: 388 KE---EMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLVLEENKLLLEQL 444
+E EM ++++ ++++E +E NK +++ + + Q + +E +L +
Sbjct: 1154 REHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLRE--KEFIMLQNEQ 1211
Query: 445 EIQQRKAK-DSHQERLQEVSKLTKQLMLLEAKTHGQEKELAENREQLEILRAKCQELKTH 503
EI Q K + + Q+R++E+ + K+ E Q KE + ++L + R + Q T
Sbjct: 1212 EISQLKKEIERTQQRMKEMESVMKEQ---EQYIATQYKEAIDLGQELRLTREQVQNSHT- 1267
Query: 504 SDGKIAVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVLQAQKKSLLLEKNSLTEQN 563
++A H+ + Q Q+E E+ +E+E++ + A L E + +
Sbjct: 1268 ---ELAEARHQQV------QAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGA----S 1314
Query: 564 KALEAELE-RAQKINRKSQKKIEVLKKQVEKAMGNEMSAHQ 603
K EA LE R Q +K ++E LK+ A EM +HQ
Sbjct: 1315 KVREAHLEARMQAEIKKLSAEVESLKE----AYHMEMISHQ 1351
Score = 56.6 bits (135), Expect = 9e-08
Identities = 87/360 (24%), Positives = 153/360 (42%), Gaps = 53/360 (14%)
Query: 313 DENDGLKMTVHRLNVELSRYQTKFRHLSKE-----ESLNIEGLPSKGPIPPWLLDIKYLS 367
+E + L V L EL + + L +E S N + P+ +LD++
Sbjct: 131 NEEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPSH 190
Query: 368 PLLL---AYEDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWR 424
P LL YE++ K K+ V +E + L ++LNK
Sbjct: 191 PGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLR-------- 242
Query: 425 QLQTQAKLVLEENKLLLE----QLEIQQRKAK----DSHQERLQEVSKLTKQLMLLEAKT 476
Q A LV + + L+ + E+ Q +AK +S Q++ V L +Q++ LEA+
Sbjct: 243 --QQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEV 300
Query: 477 HGQEKELAENREQLE----ILRAKCQELKTHSDGKIAVEVHKSIVNELKSQLQKEEEKER 532
Q+K L E +LE ++ K Q L+ + I ++V +L Q ++ + ER
Sbjct: 301 SAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKV------DLLEQTKQGKRAER 354
Query: 533 AEMEELM---EKLTVLQAQKKSLLLEKNSLTEQNKALEAELERAQKINRKSQKK------ 583
E L E Q KK + + + + + LE L +K N++ Q++
Sbjct: 355 QRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKS 414
Query: 584 -IEVLKKQV-----EKAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVL 637
+E+LK+++ E G E + N +A+ +T+ R S++ L LE+ KD +L
Sbjct: 415 ELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQ-LTESRQSILKLESELEN-KDEIL 472
Score = 50.8 bits (120), Expect = 5e-06
Identities = 103/519 (19%), Positives = 210/519 (40%), Gaps = 49/519 (9%)
Query: 256 SLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKASSQEVAA--PELLYLRKQAQELVD 313
+L E++ + ++E + KL+ +K + +++ + S +E +LL KQ +
Sbjct: 295 NLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAER 354
Query: 314 ENDGLKMTVHRLNVELSRYQTKFRHLSKEESLNIEGLPSKGPIPPWLLDIKYLSPLLLAY 373
+ + L+ +Y+ K K E + E + + + K L Y
Sbjct: 355 QRNEALYNAEELSKAFQQYKKKVAE--KLEKVQAEEEILERNLTNCEKENKRLQERCGLY 412
Query: 374 EDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLV 433
+ ++ E LKEE + +++ + +N E+ +L +S + +L+ + +++
Sbjct: 413 KSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEIL 472
Query: 434 LEENKLLLEQLEIQQRKAKDSHQERL----QEVSKLTKQLMLLEAKTHGQ---EKELAEN 486
++ L+ E E++ R A + ERL QE+ +L LE K Q ++EL
Sbjct: 473 RDKFSLMNENRELKVRVA--AQNERLDLCQQEIESSRVELRSLE-KIISQLPLKRELFGF 529
Query: 487 REQLEILRAKCQELKTHSDGKI-AVEVHKSIVNELKSQLQKEEEKERAEMEELMEKLTVL 545
+ L + + D I E +K +++EL+ +L +E AE+++L LT
Sbjct: 530 KSYLS--KYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKE----AEIQKLHANLTAN 583
Query: 546 QAQKKSLLLEKNSLTEQNKALEAE---LERAQKINRKSQKKIEVLKKQVEKAMGNEMSAH 602
Q + + + + + +LE E L Q + + KQ EK ++
Sbjct: 584 QLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGI 643
Query: 603 QYL--------ANLVGLAENITQERDSLMCLAKCL------ESEKDGVLNKVIKSNIRLG 648
+ L A L N+ + + L S+ + + K + L
Sbjct: 644 EELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLE 703
Query: 649 K-LEEKVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQA 707
K LEEK+ Y AA K ++ L+E+ E E + + +++
Sbjct: 704 KQLEEKIVAYSSIAA-KNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKI---H 759
Query: 708 LQQNREMEGELEVI------WESTFRENRRIRELLQDTL 740
L+Q++EME ++E + + F+E + +LQ +
Sbjct: 760 LEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDI 798
Score = 38.9 bits (89), Expect = 0.019
Identities = 49/263 (18%), Positives = 120/263 (45%), Gaps = 13/263 (4%)
Query: 480 EKELAENREQLEILRAK--CQELKTHSDGKIAVEVHKSIV-NELKSQLQKEEEKERAEME 536
++E+ RE+L LR + C + HS +H + + K + + +++ A +
Sbjct: 228 DQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVP 287
Query: 537 ELMEKLTVLQAQ---KKSLLLEKNSLTEQNKALEAELERAQKINRKSQKKIEV-LKKQVE 592
L E++ L+A+ + +L E + EQ++ + E E++ + +++ K++V L +Q +
Sbjct: 288 ILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTK 347
Query: 593 KAMGNEMSAHQYLANLVGLAENITQERDSLMCLAKCLESEKDGVLNKVIKSNIRLGKLEE 652
+ E ++ L N L++ Q + + + +++E++ + + +L+E
Sbjct: 348 QGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQE 407
Query: 653 KVKGYKKQAALKLGDISHRLLEQQEDFAGKTAQYRQEMRHLHQVLKDKQEVLDQALQQNR 712
+ YK + + + +L + +E+ + R +V+ E L+
Sbjct: 408 RCGLYKSELEI----LKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLES 463
Query: 713 EMEGELEVIWE--STFRENRRIR 733
E+E + E++ + S ENR ++
Sbjct: 464 ELENKDEILRDKFSLMNENRELK 486
Score = 32.3 bits (72), Expect = 1.7
Identities = 59/252 (23%), Positives = 103/252 (40%), Gaps = 44/252 (17%)
Query: 234 EITREKFEA-LKEENMDLNNMNQSLTLELNTMKQAMKELQLKLKGMEKEKRKLKEAEKAS 292
E T EK E LKE N + ++N +L K+ ++E + + E+E +LK+ + +
Sbjct: 1168 EGTLEKSELELKECNKQIESLND----KLQNAKEQLREKEFIMLQNEQEISQLKKEIERT 1223
Query: 293 SQEVAAPELL------YLRKQAQELVDENDGLKMT---VHRLNVELS--RYQT------- 334
Q + E + Y+ Q +E +D L++T V + EL+ R+Q
Sbjct: 1224 QQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREI 1283
Query: 335 --------KFRHLSKE---------ESLNIEGLPSKGPIPPWLLDIKYLSP----LLLAY 373
+ LSKE E L + +IK LS L AY
Sbjct: 1284 ERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAY 1343
Query: 374 EDMMKEKDELNATLKEEMRMFRMRVQEVVKENEELHQELNKSSAVTSEEWRQLQTQAKLV 433
M E +A K + VQ++ ++ E+ EL ++ S +Q+Q + +++
Sbjct: 1344 HMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVI 1403
Query: 434 LEENKLLLEQLE 445
N+ LL + E
Sbjct: 1404 EAANEALLTKGE 1415
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.128 0.347
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,229,686
Number of Sequences: 37866
Number of extensions: 1568709
Number of successful extensions: 21410
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 398
Number of HSP's successfully gapped in prelim test: 1283
Number of HSP's that attempted gapping in prelim test: 11365
Number of HSP's gapped (non-prelim): 6066
length of query: 783
length of database: 18,247,518
effective HSP length: 110
effective length of query: 673
effective length of database: 14,082,258
effective search space: 9477359634
effective search space used: 9477359634
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.