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Search of human proteins with 4826776
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4826776 Janus kinase 2 [Homo sapiens]
(1132 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4826776 Janus kinase 2 [Homo sapiens] 2325 0.0
gi|47157315 Janus kinase 3 [Homo sapiens] 1066 0.0
gi|102469034 janus kinase 1 [Homo sapiens] 908 0.0
gi|187608615 tyrosine kinase 2 [Homo sapiens] 756 0.0
gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sap... 189 1e-47
gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sap... 189 1e-47
gi|4503787 fyn-related kinase [Homo sapiens] 180 6e-45
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 177 7e-44
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 177 7e-44
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo... 172 1e-42
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor... 172 1e-42
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo... 172 1e-42
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo... 171 3e-42
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo... 171 3e-42
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 170 8e-42
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 170 8e-42
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 170 8e-42
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 170 8e-42
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 168 2e-41
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 168 3e-41
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 168 3e-41
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 168 3e-41
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 168 3e-41
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 168 3e-41
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 168 3e-41
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 168 3e-41
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 168 3e-41
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 168 3e-41
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 168 3e-41
gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [... 168 3e-41
>gi|4826776 Janus kinase 2 [Homo sapiens]
Length = 1132
Score = 2325 bits (6025), Expect = 0.0
Identities = 1132/1132 (100%), Positives = 1132/1132 (100%)
Query: 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSG 60
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSG
Sbjct: 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSG 60
Query: 61 EYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF 120
EYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF
Sbjct: 61 EYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF 120
Query: 121 PRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG 180
PRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
Sbjct: 121 PRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG 180
Query: 181 MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQF 240
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQF
Sbjct: 181 MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQF 240
Query: 241 SQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR 300
SQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
Sbjct: 241 SQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR 300
Query: 301 GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR 360
GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
Sbjct: 301 GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR 360
Query: 361 EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQT 420
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQT
Sbjct: 361 EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQT 420
Query: 421 GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNC 480
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNC
Sbjct: 421 GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNC 480
Query: 481 YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI 540
YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
Sbjct: 481 YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI 540
Query: 541 RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM 600
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
Sbjct: 541 RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM 600
Query: 601 MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWA 660
MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWA
Sbjct: 601 MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWA 660
Query: 661 MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP 720
MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
Sbjct: 661 MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP 720
Query: 721 PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAEL 780
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAEL
Sbjct: 721 PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAEL 780
Query: 781 ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD 840
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
Sbjct: 781 ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD 840
Query: 841 PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE 900
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
Sbjct: 841 PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE 900
Query: 901 ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI 960
ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI
Sbjct: 901 ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI 960
Query: 961 CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW 1020
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
Sbjct: 961 CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW 1020
Query: 1021 YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE 1080
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
Sbjct: 1021 YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE 1080
Query: 1081 LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 1132
LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
Sbjct: 1081 LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 1132
>gi|47157315 Janus kinase 3 [Homo sapiens]
Length = 1124
Score = 1066 bits (2757), Expect = 0.0
Identities = 547/1091 (50%), Positives = 747/1091 (68%), Gaps = 26/1091 (2%)
Query: 48 GKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDES 107
G L+F G+++AE++C+ A+KA GI PVYH++FAL +E W+PP+H+F ++++
Sbjct: 34 GPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDA 93
Query: 108 TRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIK 167
+ +LYRIRFYFP W+ G + +R G+ + + +LD V+ +LFAQ R D V G +
Sbjct: 94 STQVLLYRIRFYFPNWF--GLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLP 151
Query: 168 VPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRK 227
V ++ + Q ECL +AVLD+ R+A+E Q P + ++SYK LP +R IQ +TR+
Sbjct: 152 VGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRR 211
Query: 228 RIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFAT 287
RIR RR +++ + C+A +L KY+++LE L A E F V PG+ G +
Sbjct: 212 RIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGA-LGGHDGLGL 270
Query: 288 IIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEG-SNESRVVTIHK 346
+ + G+GGI W++G+ ++ LQ +CDFP I+D+SIKQA + G + E R+VT+ +
Sbjct: 271 LRVAGDGGIAWTQGE--------QEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTR 322
Query: 347 QDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISM 406
D + LE E L EALSFV+L+DGY+RLT D+ H+ CKEVAPP +LE + CHGPI++
Sbjct: 323 TDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITL 382
Query: 407 DFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSG 466
DFAI+KLK G++ G YVLR SP+DF+ + LT V+ +YK CLI ++ + L G
Sbjct: 383 DFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVG 442
Query: 467 TKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTL 526
+ SSL++LL + D + T CC P+PK+KSNL+V + PTS +
Sbjct: 443 LSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRG--HSPPTSSLV 500
Query: 527 QRPTH--MNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLD 584
Q + ++QM FHKI + L ++E+LG G+FTKI++G R EV D G+ +TEVLLKV+D
Sbjct: 501 QPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVD-GEARKTEVLLKVMD 559
Query: 585 KAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNC 644
H+N ESF EAAS+MS++S++HLVL +GVC+ GD +VQEFV G++D YL+K +
Sbjct: 560 AKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDST-MVQEFVHLGAIDMYLRKRGHL 618
Query: 645 INILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISI 704
+ WKL+V KQLA+A+++LE+ L HGNV A+ +LL RE G+PPFIKLSDPG+S
Sbjct: 619 VPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREG--ADGSPPFIKLSDPGVSP 676
Query: 705 TVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQ 764
VL ++L +RIPWV PEC+ + L+L DKW FG T+WE+ SG P+SALD +KLQ
Sbjct: 677 AVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQ 736
Query: 765 FYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPN 824
FYEDR QLPAPKW ELA LI CM YEP RPSFRA+IRDLNSL + DYELL+ D P
Sbjct: 737 FYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLS--DPTPG 794
Query: 825 M---RIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAV 881
R G + + +DPT FEERHLK++ QLGKGNFGSVE+CRYDPL DNTG +VAV
Sbjct: 795 ALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAV 854
Query: 882 KKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYL 941
K+LQHS + RDF+REI+ILK+L D IVKY+GV Y GR++L+L+MEYLP G LRD+L
Sbjct: 855 KQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFL 914
Query: 942 QKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVL 1001
Q+H+ R+D +LL Y+SQICKGMEYLG++R +HRDLA RNILVE+E VKI DFGL K+L
Sbjct: 915 QRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLL 974
Query: 1002 PQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEF 1061
P DK+YY V+EPG+SPIFWYAPESL+++ FS SDVWSFGVVLYELFTY +KS SP AEF
Sbjct: 975 PLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEF 1034
Query: 1062 MRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLAL 1121
+RM+G ++ + L+ELL+ RLP P CP E++ +M CW + RPSF L
Sbjct: 1035 LRMMGCERDVPALC-RLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGP 1093
Query: 1122 RVDQIRDNMAG 1132
++D + G
Sbjct: 1094 QLDMLWSGSRG 1104
>gi|102469034 janus kinase 1 [Homo sapiens]
Length = 1154
Score = 908 bits (2347), Expect = 0.0
Identities = 502/1151 (43%), Positives = 704/1151 (61%), Gaps = 105/1151 (9%)
Query: 36 DPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIW 95
+P ++V Y S+ + L SGEY AEE+CI A++AC I+P+ HN+FAL E ++W
Sbjct: 33 EPGVEVIFY----LSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLW 88
Query: 96 YPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNR--AYRHGISR---GAE-------AP 143
Y PN +D+ + YR+RFYF W+ + N +RH + G E P
Sbjct: 89 YAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATP 148
Query: 144 LLDDFVMSYLFAQWRHDFVH--GWIKVPVT----HETQEECLGMAVLDMMRIAKENDQTP 197
LLD + YLFAQ ++D V I+ P T H+ + ECLGMAVL + A
Sbjct: 149 LLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQL 208
Query: 198 LAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQ-----CKATARNLKL 252
+ ISYK ++P+ + I+ ++LTR RI F+ F+++F+ + +LK+
Sbjct: 209 PELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKV 268
Query: 253 KYLINLETLQSAFYTEKFEVKEP-----------GSGPSGEEIFATIIITGNGGIQWSR- 300
KYL LETL + E FE S G ++ +++TGN GIQW
Sbjct: 269 KYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHK 328
Query: 301 -------------------GKHKESETLTE--QDLQLYCDFPNIIDVSIKQANQEGSNES 339
KHK+ E + ++ + FP I + IK++
Sbjct: 329 PNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKES-------- 380
Query: 340 RVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSN 399
VV+I+KQD K +E++LSS EALSFVSL+DGY+RLTADAHHYLC +VAPP ++ NIQ+
Sbjct: 381 -VVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNG 439
Query: 400 CHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAV-ERENVIE-----YKHCL 453
CHGPI ++AI+KL++ G++ G+YVLR S DF+ +T E+ ++ +K+
Sbjct: 440 CHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQ 499
Query: 454 ITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFR 513
I + Y+L G+ ++F SL DL++ + + +R+DNI F +CC PKP++ SNLLV
Sbjct: 500 IEVQKGR-YSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVAT 558
Query: 514 TNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGD---Y 570
P P M+Q+ F +I +DL+ E LG+GT T I+ G + D
Sbjct: 559 KKAQEWQPVYP-------MSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGT 611
Query: 571 GQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVK 630
+ + +V+LKVLD +HR+ S +FFEAASMM ++SHKH+V YGVCV ENI+V+EFV+
Sbjct: 612 SEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVE 671
Query: 631 FGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREE-DRKT 689
G LD ++ + + + WK +VAKQLA A+ +LE+ L+HGNVC KN+LL RE D +
Sbjct: 672 GGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSEC 731
Query: 690 GNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSG 749
G PFIKLSDPGI ITVL + ERIPW+ PEC+E+ KNL++A DKWSFGTTLWEIC
Sbjct: 732 G--PFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYN 789
Query: 750 GDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLF 809
G+ PL K +FYE R + P ELA+L+ CM+Y+P+ RP FRAI+RD+N L
Sbjct: 790 GEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLE 849
Query: 810 TPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYD 869
+ ++++E + DPT FE+R LK ++ LG+G+FG VE+CRYD
Sbjct: 850 EQNPDIVSEKKPATEV--------------DPTHFEKRFLKRIRDLGEGHFGKVELCRYD 895
Query: 870 PLQDNTGEVVAVKKLQ-HSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLI 928
P DNTGE VAVK L+ S H+ D ++EIEIL++L H+NIVKYKG+C G +KLI
Sbjct: 896 PEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLI 955
Query: 929 MEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENEN 988
ME+LP GSL++YL K+K +I+ + L+Y QICKGM+YLG+++Y+HRDLA RN+LVE+E+
Sbjct: 956 MEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEH 1015
Query: 989 RVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELF 1048
+VKIGDFGLTK + DKEYY VK+ +SP+FWYAPE L +SKF +ASDVWSFGV L+EL
Sbjct: 1016 QVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELL 1075
Query: 1049 TYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNN 1108
TY + SP A F++MIG GQM V L+ LK RLP P CPDE+Y +M +CW
Sbjct: 1076 TYCDSDSSPMALFLKMIG-PTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEF 1134
Query: 1109 NVNQRPSFRDL 1119
+ R SF++L
Sbjct: 1135 QPSNRTSFQNL 1145
Score = 96.3 bits (238), Expect = 1e-19
Identities = 78/298 (26%), Positives = 132/298 (44%), Gaps = 30/298 (10%)
Query: 529 PTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHR 588
PTH + +IR+ LG+G F K+ GD E + + ++
Sbjct: 867 PTHFEKRFLKRIRD--------LGEGHFGKVELCRYDPEGD--NTGEQVAVKSLKPESGG 916
Query: 589 NYSESFFEAASMMSKLSHKHLVLNYGVCV--CGDENILVQEFVKFGSLDTYLKKNKNCIN 646
N+ + ++ L H+++V G+C G+ L+ EF+ GSL YL KNKN IN
Sbjct: 917 NHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKIN 976
Query: 647 ILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITV 706
+ +L+ A Q+ M +L +H ++ A+N+L+ E K G+ K +
Sbjct: 977 LKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYT 1036
Query: 707 LPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEI---CSGGDKPLSA------- 756
+ KD + W PEC+ K +A+D WSFG TL E+ C P++
Sbjct: 1037 V-KDDRDSPVFWYAPECLMQSK-FYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGP 1094
Query: 757 ----LDSQRKLQFYEDRHQLPAPKWA--ELANLINNCMDYEPDFRPSFRAIIRDLNSL 808
+ R + ++ +LP P E+ L+ C +++P R SF+ +I +L
Sbjct: 1095 THGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL 1152
>gi|187608615 tyrosine kinase 2 [Homo sapiens]
Length = 1187
Score = 756 bits (1952), Expect = 0.0
Identities = 451/1192 (37%), Positives = 647/1192 (54%), Gaps = 139/1192 (11%)
Query: 39 LQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPP 98
L+V L+ + ++TF AEE+CI + GITP N+FAL ++W PP
Sbjct: 28 LKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPP 87
Query: 99 NHVFHIDESTRHNVLYRIRFYFPRWYCSGSNR--AYRHGISRGAEAP---------LLDD 147
NH+ I + +RIRFYF W+ YR G G EA LLD
Sbjct: 88 NHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCG-PPGTEASSDQTAQGMQLLDP 146
Query: 148 FVMSYLFAQWRHDFVHGWIKV------PVTHETQEECLGMAVLDMMRIAKENDQTPLAIY 201
YLF Q +H+FV+ + H + E LGMA L + +A + +
Sbjct: 147 ASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVA 206
Query: 202 NSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETL 261
S+K +P+ R I+ + LTR R+R FRRF++ F + + + + +KYL LE L
Sbjct: 207 KKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERL 266
Query: 262 QSAFYTEKFEV----------------KEPGSGPS--GEEIFA-----TIIITGNGGIQW 298
F TE+ V ++ G P+ G E A +++TG GGIQW
Sbjct: 267 APRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQW 326
Query: 299 ---------------SRGKHKESETL-----------------TEQDLQLYCDFPNIIDV 326
S G++ ++ E +CDF +I V
Sbjct: 327 WPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHV 386
Query: 327 SIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKE 386
+K+ V+IH+QD K LE+ L S ALSFVSL+DGY+RLTAD+ HYLC E
Sbjct: 387 VLKE---------HCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHE 437
Query: 387 VAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENV 446
VAPP ++ +I+ HGP+ F +KL+ + GLY++ S + LT A +
Sbjct: 438 VAPPRLVMSIRDGIHGPLLEPFVQAKLRP---EDGLYLIHWSTSHPYRLILTVAQRSQAP 494
Query: 447 IEYKHCLITKNENEEYN----LSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPK 502
+ + K E+ + L G ++F S+++L Q +R+ + F +CC P+
Sbjct: 495 DGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQ 554
Query: 503 PKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKG 562
P + SNL++ R S R +++Q+ FH++ +++ LGQGT T +++G
Sbjct: 555 PGETSNLIIMRGARASP--------RTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEG 606
Query: 563 VRREVG-------------------DYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSK 603
R G D GQ E V+LKVLD +H + + +F+E AS+MS+
Sbjct: 607 RLRVEGSGDPEEGKMDDEDPLVPGRDRGQ--ELRVVLKVLDPSHHDIALAFYETASLMSQ 664
Query: 604 LSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHF 663
+SH HL +GVCV G ENI+V E+V+ G LD +L++ + + + WK+ VA+QLA A+ +
Sbjct: 665 VSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSY 724
Query: 664 LEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPEC 723
LE L+HGNVC +NILL R G PFIKLSDPG+ + L ++ ERIPW+ PEC
Sbjct: 725 LENKNLVHGNVCGRNILLARL-GLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPEC 783
Query: 724 IENPKN-LNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELAN 782
+ N L+ A DKW FG TL EIC G+ PL + K FY+ +H+LP P +LA
Sbjct: 784 LPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLAT 843
Query: 783 LINNCMDYEPDFRPSFRAIIRDLNSLFTPDY-ELLTENDMLPNMRIGALGFSGAFEDRDP 841
L + C+ YEP RPSFR I+RDL L + ++LT N P DP
Sbjct: 844 LTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPAS--------------DP 889
Query: 842 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHST-EEHLRDFEREIE 900
T F +R+LK ++ LG+G+FG V + YDP D TGE+VAVK L+ +H +++EI+
Sbjct: 890 TVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEID 949
Query: 901 ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI 960
IL++L H++I+KYKG C G ++L+L+MEY+P GSLRDYL +H I +LL + QI
Sbjct: 950 ILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS--IGLAQLLLFAQQI 1007
Query: 961 CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW 1020
C+GM YL + YIHRDLA RN+L++N+ VKIGDFGL K +P+ EYY+V+E G+SP+FW
Sbjct: 1008 CEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFW 1067
Query: 1021 YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE 1080
YAPE L E KF ASDVWSFGV LYEL T+ + S+SPP +F+ +IG QGQM V L E
Sbjct: 1068 YAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIG-IAQGQMTVLRLTE 1126
Query: 1081 LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 1132
LL+ RLPRPD CP E+Y +M CW + RP+F +L + + + G
Sbjct: 1127 LLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQG 1178
>gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sapiens]
Length = 1038
Score = 189 bits (480), Expect = 1e-47
Identities = 112/280 (40%), Positives = 163/280 (58%), Gaps = 23/280 (8%)
Query: 846 ERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQH---STEEHLRDFEREIEIL 902
E+ L+ L++LG G+FG V +D T V AVK L+ S E + DF RE+ +
Sbjct: 123 EKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSV-AVKCLKPDVLSQPEAMDDFIREVNAM 181
Query: 903 KSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICK 962
SL H N+++ GV + +K++ E P GSL D L+KH+ L +Y Q+ +
Sbjct: 182 HSLDHRNLIRLYGVVLTPP---MKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAE 238
Query: 963 GMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYA 1022
GM YL +KR+IHRDLA RN+L+ + VKIGDFGL + LPQ+ ++Y ++E + P W A
Sbjct: 239 GMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCA 298
Query: 1023 PESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELL 1082
PESL FS ASD W FGV L+E+FTY ++ ++ + G+ + H I+
Sbjct: 299 PESLKTRTFSHASDTWMFGVTLWEMFTYGQE------PWIGLNGSQ------ILHKID-- 344
Query: 1083 KNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALR 1122
K RLPRP+ CP +IY +M +CW + RP+F +ALR
Sbjct: 345 KEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTF--VALR 382
Score = 87.4 bits (215), Expect = 7e-17
Identities = 88/330 (26%), Positives = 150/330 (45%), Gaps = 43/330 (13%)
Query: 518 SDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETE 577
S P P + P Q + I +DL E LG G+F VRR D
Sbjct: 102 SPAPGGPAGEGPL---QSLTCLIGEKDLRLLEKLGDGSFGV----VRRGEWDAPSGKTVS 154
Query: 578 VLLKVLDKAHRNYSES---FFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSL 634
V +K L + E+ F + M L H++L+ YGV + +V E GSL
Sbjct: 155 VAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMK-MVTELAPLGSL 213
Query: 635 DTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPF 694
L+K++ + A Q+A M +LE IH ++ A+N+LL +
Sbjct: 214 LDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRD--------L 265
Query: 695 IKLSDPGISITVLPKD----ILQE--RIP--WVPPECIENPKNLNLATDKWSFGTTLWEI 746
+K+ D G+ + LP++ ++QE ++P W PE ++ + + A+D W FG TLWE+
Sbjct: 266 VKIGDFGL-MRALPQNDDHYVMQEHRKVPFAWCAPESLKT-RTFSHASDTWMFGVTLWEM 323
Query: 747 CSGGDKPLSALDSQRKL-QFYEDRHQLPAPKWA--ELANLINNCMDYEPDFRPSFRAI-- 801
+ G +P L+ + L + ++ +LP P+ ++ N++ C ++P+ RP+F A+
Sbjct: 324 FTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRD 383
Query: 802 ---------IRDLNSLFTPDYELLTENDML 822
+R L PD + ND++
Sbjct: 384 FLLEAQPTDMRALQDFEEPDKLHIQMNDVI 413
>gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sapiens]
Length = 1086
Score = 189 bits (480), Expect = 1e-47
Identities = 112/280 (40%), Positives = 163/280 (58%), Gaps = 23/280 (8%)
Query: 846 ERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQH---STEEHLRDFEREIEIL 902
E+ L+ L++LG G+FG V +D T V AVK L+ S E + DF RE+ +
Sbjct: 186 EKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSV-AVKCLKPDVLSQPEAMDDFIREVNAM 244
Query: 903 KSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICK 962
SL H N+++ GV + +K++ E P GSL D L+KH+ L +Y Q+ +
Sbjct: 245 HSLDHRNLIRLYGVVLTPP---MKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAE 301
Query: 963 GMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYA 1022
GM YL +KR+IHRDLA RN+L+ + VKIGDFGL + LPQ+ ++Y ++E + P W A
Sbjct: 302 GMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCA 361
Query: 1023 PESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELL 1082
PESL FS ASD W FGV L+E+FTY ++ ++ + G+ + H I+
Sbjct: 362 PESLKTRTFSHASDTWMFGVTLWEMFTYGQE------PWIGLNGSQ------ILHKID-- 407
Query: 1083 KNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALR 1122
K RLPRP+ CP +IY +M +CW + RP+F +ALR
Sbjct: 408 KEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTF--VALR 445
Score = 87.4 bits (215), Expect = 7e-17
Identities = 88/330 (26%), Positives = 150/330 (45%), Gaps = 43/330 (13%)
Query: 518 SDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETE 577
S P P + P Q + I +DL E LG G+F VRR D
Sbjct: 165 SPAPGGPAGEGPL---QSLTCLIGEKDLRLLEKLGDGSFGV----VRRGEWDAPSGKTVS 217
Query: 578 VLLKVLDKAHRNYSES---FFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSL 634
V +K L + E+ F + M L H++L+ YGV + +V E GSL
Sbjct: 218 VAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMK-MVTELAPLGSL 276
Query: 635 DTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPF 694
L+K++ + A Q+A M +LE IH ++ A+N+LL +
Sbjct: 277 LDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRD--------L 328
Query: 695 IKLSDPGISITVLPKD----ILQE--RIP--WVPPECIENPKNLNLATDKWSFGTTLWEI 746
+K+ D G+ + LP++ ++QE ++P W PE ++ + + A+D W FG TLWE+
Sbjct: 329 VKIGDFGL-MRALPQNDDHYVMQEHRKVPFAWCAPESLKT-RTFSHASDTWMFGVTLWEM 386
Query: 747 CSGGDKPLSALDSQRKL-QFYEDRHQLPAPKWA--ELANLINNCMDYEPDFRPSFRAI-- 801
+ G +P L+ + L + ++ +LP P+ ++ N++ C ++P+ RP+F A+
Sbjct: 387 FTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRD 446
Query: 802 ---------IRDLNSLFTPDYELLTENDML 822
+R L PD + ND++
Sbjct: 447 FLLEAQPTDMRALQDFEEPDKLHIQMNDVI 476
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 180 bits (457), Expect = 6e-45
Identities = 104/295 (35%), Positives = 163/295 (55%), Gaps = 25/295 (8%)
Query: 832 FSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEH 891
F +++ D + + ++ L++LG G FG V ++ L +NT V AVK L+ + +
Sbjct: 217 FDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEV----WEGLWNNTTPV-AVKTLKPGSMDP 271
Query: 892 LRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHI 951
DF RE +I+K+L+H +++ VC + +I E + +GSL++YLQ H+
Sbjct: 272 -NDFLREAQIMKNLRHPKLIQLYAVCTLEDP--IYIITELMRHGSLQEYLQNDTGSKIHL 328
Query: 952 -KLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKE-YYK 1009
+ + +Q+ GM YL ++ YIHRDLA RN+LV N K+ DFGL +V D E Y+
Sbjct: 329 TQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYE 388
Query: 1010 VKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDK 1069
+ + P+ W APE++ +KFS+ SDVWSFG++LYE+ TY G
Sbjct: 389 SRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITY---------------GKMP 433
Query: 1070 QGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVD 1124
M +I++L N RLP+P CP + Y IM ECWN +RP+F L +++
Sbjct: 434 YSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLE 488
Score = 108 bits (269), Expect = 4e-23
Identities = 105/436 (24%), Positives = 187/436 (42%), Gaps = 65/436 (14%)
Query: 402 GPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEE 461
G I A +L + N+TG +++R S ++ L+ + KH I + +
Sbjct: 119 GAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVL----DGAVVKHYRIKRLDEGG 174
Query: 462 YNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCC----PPKPKDKSNLLVFRTNGV 517
+ L+ ++ FS+L + ++ Y T SD + + K C P P D S V +
Sbjct: 175 FFLT-RRRIFSTLNEFVSHY---TKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQW--- 227
Query: 518 SDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETE 577
+I + + LG G F ++++G+ T
Sbjct: 228 ---------------------EIDRNSIQLLKRLGSGQFGEVWEGLWNNT--------TP 258
Query: 578 VLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTY 637
V +K L + ++ F A +M L H L+ Y VC D ++ E ++ GSL Y
Sbjct: 259 VAVKTLKPGSMDPND-FLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEY 317
Query: 638 LKKNKNC-INILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIK 696
L+ + I++ ++++A Q+A M +LE IH ++ A+N+L+ G K
Sbjct: 318 LQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLV--------GEHNIYK 369
Query: 697 LSDPGIS--ITVLPKDILQER------IPWVPPECIENPKNLNLATDKWSFGTTLWEICS 748
++D G++ V +DI + R + W PE I + K ++ +D WSFG L+EI +
Sbjct: 370 VADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNK-FSIKSDVWSFGILLYEIIT 428
Query: 749 GGDKPLSALDSQRKLQFYEDRHQLPAPKWA--ELANLINNCMDYEPDFRPSFRAIIRDLN 806
G P S + + +Q ++LP P + N++ C + EP RP+F + L
Sbjct: 429 YGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLE 488
Query: 807 SLFTPDYELLTENDML 822
F D N+ +
Sbjct: 489 DYFETDSSYSDANNFI 504
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 177 bits (448), Expect = 7e-44
Identities = 101/287 (35%), Positives = 159/287 (55%), Gaps = 25/287 (8%)
Query: 834 GAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLR 893
G + D + E + +LG G +G V Y+ + VAVK L+ T E +
Sbjct: 227 GVSPNYDKWEMERTDITMKHKLGGGQYGEV----YEGVWKKYSLTVAVKTLKEDTME-VE 281
Query: 894 DFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQK-HKERIDHIK 952
+F +E ++K ++H N+V+ GVC +I E++ YG+L DYL++ +++ ++ +
Sbjct: 282 EFLKEAAVMKEIKHPNLVQLLGVC--TREPPFYIITEFMTYGNLLDYLRECNRQEVNAVV 339
Query: 953 LLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKE 1012
LL +QI MEYL K +IHRDLA RN LV + VK+ DFGL++++ D Y
Sbjct: 340 LLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT--YTAHA 397
Query: 1013 PGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQ 1072
+ PI W APESL +KFS+ SDVW+FGV+L+E+ TY G
Sbjct: 398 GAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATY---------------GMSPYPG 442
Query: 1073 MIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 1119
+ + + ELL+ + R+ RP+GCP+++Y +M CW N + RPSF ++
Sbjct: 443 IDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEI 489
Score = 104 bits (259), Expect = 5e-22
Identities = 73/280 (26%), Positives = 136/280 (48%), Gaps = 27/280 (9%)
Query: 539 KIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAA 598
++ D+ LG G + ++++GV ++ + V +K L K E F + A
Sbjct: 236 EMERTDITMKHKLGGGQYGEVYEGVWKK-------YSLTVAVKTL-KEDTMEVEEFLKEA 287
Query: 599 SMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKK-NKNCINILWKLEVAKQL 657
++M ++ H +LV GVC ++ EF+ +G+L YL++ N+ +N + L +A Q+
Sbjct: 288 AVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQI 347
Query: 658 AWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQER-- 715
+ AM +LE+ IH ++ A+N L+ G +K++D G+S ++ D
Sbjct: 348 SSAMEYLEKKNFIHRDLAARNCLV--------GENHLVKVADFGLS-RLMTGDTYTAHAG 398
Query: 716 ----IPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQ 771
I W PE + K ++ +D W+FG LWEI + G P +D + + E ++
Sbjct: 399 AKFPIKWTAPESLAYNK-FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYR 457
Query: 772 LPAPKWA--ELANLINNCMDYEPDFRPSFRAIIRDLNSLF 809
+ P+ ++ L+ C + P RPSF I + ++F
Sbjct: 458 MERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMF 497
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 177 bits (448), Expect = 7e-44
Identities = 101/287 (35%), Positives = 159/287 (55%), Gaps = 25/287 (8%)
Query: 834 GAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLR 893
G + D + E + +LG G +G V Y+ + VAVK L+ T E +
Sbjct: 246 GVSPNYDKWEMERTDITMKHKLGGGQYGEV----YEGVWKKYSLTVAVKTLKEDTME-VE 300
Query: 894 DFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQK-HKERIDHIK 952
+F +E ++K ++H N+V+ GVC +I E++ YG+L DYL++ +++ ++ +
Sbjct: 301 EFLKEAAVMKEIKHPNLVQLLGVC--TREPPFYIITEFMTYGNLLDYLRECNRQEVNAVV 358
Query: 953 LLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKE 1012
LL +QI MEYL K +IHRDLA RN LV + VK+ DFGL++++ D Y
Sbjct: 359 LLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT--YTAHA 416
Query: 1013 PGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQ 1072
+ PI W APESL +KFS+ SDVW+FGV+L+E+ TY G
Sbjct: 417 GAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATY---------------GMSPYPG 461
Query: 1073 MIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 1119
+ + + ELL+ + R+ RP+GCP+++Y +M CW N + RPSF ++
Sbjct: 462 IDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEI 508
Score = 104 bits (259), Expect = 5e-22
Identities = 73/280 (26%), Positives = 136/280 (48%), Gaps = 27/280 (9%)
Query: 539 KIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAA 598
++ D+ LG G + ++++GV ++ + V +K L K E F + A
Sbjct: 255 EMERTDITMKHKLGGGQYGEVYEGVWKK-------YSLTVAVKTL-KEDTMEVEEFLKEA 306
Query: 599 SMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKK-NKNCINILWKLEVAKQL 657
++M ++ H +LV GVC ++ EF+ +G+L YL++ N+ +N + L +A Q+
Sbjct: 307 AVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQI 366
Query: 658 AWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQER-- 715
+ AM +LE+ IH ++ A+N L+ G +K++D G+S ++ D
Sbjct: 367 SSAMEYLEKKNFIHRDLAARNCLV--------GENHLVKVADFGLS-RLMTGDTYTAHAG 417
Query: 716 ----IPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQ 771
I W PE + K ++ +D W+FG LWEI + G P +D + + E ++
Sbjct: 418 AKFPIKWTAPESLAYNK-FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYR 476
Query: 772 LPAPKWA--ELANLINNCMDYEPDFRPSFRAIIRDLNSLF 809
+ P+ ++ L+ C + P RPSF I + ++F
Sbjct: 477 MERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMF 516
>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform 1
[Homo sapiens]
Length = 790
Score = 172 bits (437), Expect = 1e-42
Identities = 107/306 (34%), Positives = 154/306 (50%), Gaps = 33/306 (10%)
Query: 836 FEDRDPTQFEERHLKFLQQLGKGNFGSVEMCR-YDPLQDNTGEVVAVKKLQHSTEEHLRD 894
F D + R + +LG+G FG V + ++ L + +VAVK L+ ++E +D
Sbjct: 491 FSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD 550
Query: 895 FEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHI--- 951
F+RE E+L LQH +IV++ GVC R L ++ EY+ +G L +L+ H +
Sbjct: 551 FQREAELLTMLQHQHIVRFFGVCTEG--RPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGG 608
Query: 952 -----------KLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKV 1000
+LL SQ+ GM YL ++HRDLATRN LV VKIGDFG+++
Sbjct: 609 EDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRD 668
Query: 1001 LPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE 1060
+ +YY+V PI W PES+ KF+ SDVWSFGVVL+E+FTY
Sbjct: 669 I-YSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTY---------- 717
Query: 1061 FMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLA 1120
G Q+ I+ + L RP CP E+Y IM CW QR S +D+
Sbjct: 718 -----GKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVH 772
Query: 1121 LRVDQI 1126
R+ +
Sbjct: 773 ARLQAL 778
Score = 99.4 bits (246), Expect = 2e-20
Identities = 75/305 (24%), Positives = 133/305 (43%), Gaps = 33/305 (10%)
Query: 526 LQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDK 585
++ P + + H I+ D++ LG+G F K+F + + + V +K L +
Sbjct: 485 IENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNL--LPEQDKMLVAVKALKE 542
Query: 586 AHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCI 645
A + + F A +++ L H+H+V +GVC G ++V E+++ G L+ +L+ +
Sbjct: 543 ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDA 602
Query: 646 NIL--------------WKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGN 691
+L L VA Q+A M +L +H ++ +N L+ G
Sbjct: 603 KLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV--------GQ 654
Query: 692 PPFIKLSDPGISITVLPKDILQE------RIPWVPPECIENPKNLNLATDKWSFGTTLWE 745
+K+ D G+S + D + I W+PPE I K +D WSFG LWE
Sbjct: 655 GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRK-FTTESDVWSFGVVLWE 713
Query: 746 ICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWA--ELANLINNCMDYEPDFRPSFRAIIR 803
I + G +P L + + +L P+ E+ ++ C EP R S + +
Sbjct: 714 IFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHA 773
Query: 804 DLNSL 808
L +L
Sbjct: 774 RLQAL 778
>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
[Homo sapiens]
Length = 796
Score = 172 bits (437), Expect = 1e-42
Identities = 107/306 (34%), Positives = 154/306 (50%), Gaps = 33/306 (10%)
Query: 836 FEDRDPTQFEERHLKFLQQLGKGNFGSVEMCR-YDPLQDNTGEVVAVKKLQHSTEEHLRD 894
F D + R + +LG+G FG V + ++ L + +VAVK L+ ++E +D
Sbjct: 497 FSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD 556
Query: 895 FEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHI--- 951
F+RE E+L LQH +IV++ GVC R L ++ EY+ +G L +L+ H +
Sbjct: 557 FQREAELLTMLQHQHIVRFFGVCTEG--RPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGG 614
Query: 952 -----------KLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKV 1000
+LL SQ+ GM YL ++HRDLATRN LV VKIGDFG+++
Sbjct: 615 EDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRD 674
Query: 1001 LPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE 1060
+ +YY+V PI W PES+ KF+ SDVWSFGVVL+E+FTY
Sbjct: 675 I-YSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTY---------- 723
Query: 1061 FMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLA 1120
G Q+ I+ + L RP CP E+Y IM CW QR S +D+
Sbjct: 724 -----GKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVH 778
Query: 1121 LRVDQI 1126
R+ +
Sbjct: 779 ARLQAL 784
Score = 99.4 bits (246), Expect = 2e-20
Identities = 75/305 (24%), Positives = 133/305 (43%), Gaps = 33/305 (10%)
Query: 526 LQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDK 585
++ P + + H I+ D++ LG+G F K+F + + + V +K L +
Sbjct: 491 IENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNL--LPEQDKMLVAVKALKE 548
Query: 586 AHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCI 645
A + + F A +++ L H+H+V +GVC G ++V E+++ G L+ +L+ +
Sbjct: 549 ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDA 608
Query: 646 NIL--------------WKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGN 691
+L L VA Q+A M +L +H ++ +N L+ G
Sbjct: 609 KLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV--------GQ 660
Query: 692 PPFIKLSDPGISITVLPKDILQE------RIPWVPPECIENPKNLNLATDKWSFGTTLWE 745
+K+ D G+S + D + I W+PPE I K +D WSFG LWE
Sbjct: 661 GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRK-FTTESDVWSFGVVLWE 719
Query: 746 ICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWA--ELANLINNCMDYEPDFRPSFRAIIR 803
I + G +P L + + +L P+ E+ ++ C EP R S + +
Sbjct: 720 IFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHA 779
Query: 804 DLNSL 808
L +L
Sbjct: 780 RLQAL 784
>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform 3
[Homo sapiens]
Length = 760
Score = 172 bits (437), Expect = 1e-42
Identities = 107/306 (34%), Positives = 154/306 (50%), Gaps = 33/306 (10%)
Query: 836 FEDRDPTQFEERHLKFLQQLGKGNFGSVEMCR-YDPLQDNTGEVVAVKKLQHSTEEHLRD 894
F D + R + +LG+G FG V + ++ L + +VAVK L+ ++E +D
Sbjct: 461 FSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD 520
Query: 895 FEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHI--- 951
F+RE E+L LQH +IV++ GVC R L ++ EY+ +G L +L+ H +
Sbjct: 521 FQREAELLTMLQHQHIVRFFGVCTEG--RPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGG 578
Query: 952 -----------KLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKV 1000
+LL SQ+ GM YL ++HRDLATRN LV VKIGDFG+++
Sbjct: 579 EDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRD 638
Query: 1001 LPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAE 1060
+ +YY+V PI W PES+ KF+ SDVWSFGVVL+E+FTY
Sbjct: 639 I-YSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTY---------- 687
Query: 1061 FMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLA 1120
G Q+ I+ + L RP CP E+Y IM CW QR S +D+
Sbjct: 688 -----GKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVH 742
Query: 1121 LRVDQI 1126
R+ +
Sbjct: 743 ARLQAL 748
Score = 99.4 bits (246), Expect = 2e-20
Identities = 75/305 (24%), Positives = 133/305 (43%), Gaps = 33/305 (10%)
Query: 526 LQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDK 585
++ P + + H I+ D++ LG+G F K+F + + + V +K L +
Sbjct: 455 IENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNL--LPEQDKMLVAVKALKE 512
Query: 586 AHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCI 645
A + + F A +++ L H+H+V +GVC G ++V E+++ G L+ +L+ +
Sbjct: 513 ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDA 572
Query: 646 NIL--------------WKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGN 691
+L L VA Q+A M +L +H ++ +N L+ G
Sbjct: 573 KLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV--------GQ 624
Query: 692 PPFIKLSDPGISITVLPKDILQE------RIPWVPPECIENPKNLNLATDKWSFGTTLWE 745
+K+ D G+S + D + I W+PPE I K +D WSFG LWE
Sbjct: 625 GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRK-FTTESDVWSFGVVLWE 683
Query: 746 ICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWA--ELANLINNCMDYEPDFRPSFRAIIR 803
I + G +P L + + +L P+ E+ ++ C EP R S + +
Sbjct: 684 IFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHA 743
Query: 804 DLNSL 808
L +L
Sbjct: 744 RLQAL 748
>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-2 precursor [Homo sapiens]
Length = 1292
Score = 171 bits (434), Expect = 3e-42
Identities = 99/277 (35%), Positives = 154/277 (55%), Gaps = 20/277 (7%)
Query: 845 EERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLR-DFEREIEILK 903
+E LK ++ LG G FG+V + P + VA+K L +T +F E I+
Sbjct: 714 KETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMA 773
Query: 904 SLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKG 963
S+ H ++V+ GVC S ++L+ + +P+G L +Y+ +HK+ I LL + QI KG
Sbjct: 774 SMDHPHLVRLLGVCLSP---TIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKG 830
Query: 964 MEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAP 1023
M YL +R +HRDLA RN+LV++ N VKI DFGL ++L D++ Y + G+ PI W A
Sbjct: 831 MMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNA-DGGKMPIKWMAL 889
Query: 1024 ESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLK 1083
E + KF+ SDVWS+GV ++EL T+ G + + +LL+
Sbjct: 890 ECIHYRKFTHQSDVWSYGVTIWELMTF---------------GGKPYDGIPTREIPDLLE 934
Query: 1084 NNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLA 1120
RLP+P C ++YM+M +CW + + RP F++LA
Sbjct: 935 KGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELA 971
Score = 94.0 bits (232), Expect = 7e-19
Identities = 75/295 (25%), Positives = 138/295 (46%), Gaps = 24/295 (8%)
Query: 524 PTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVL 583
P T NQ ++ +L + LG G F ++KG+ G+ ++ V +K+L
Sbjct: 697 PLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKI---PVAIKIL 753
Query: 584 DKAHRNYSE-SFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNK 642
++ + F + A +M+ + H HLV GVC+ LV + + G L Y+ ++K
Sbjct: 754 NETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLEYVHEHK 812
Query: 643 NCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGI 702
+ I L Q+A M +LEE L+H ++ A+N+L+ +P +K++D G+
Sbjct: 813 DNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLV--------KSPNHVKITDFGL 864
Query: 703 SITVLPKDILQER-------IPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLS 755
+ +L D + I W+ ECI K + +D WS+G T+WE+ + G KP
Sbjct: 865 A-RLLEGDEKEYNADGGKMPIKWMALECIHYRKFTH-QSDVWSYGVTIWELMTFGGKPYD 922
Query: 756 ALDSQRKLQFYEDRHQLPAPK--WAELANLINNCMDYEPDFRPSFRAIIRDLNSL 808
+ ++ E +LP P ++ ++ C + D RP F+ + + + +
Sbjct: 923 GIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRM 977
>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-1 precursor [Homo sapiens]
Length = 1308
Score = 171 bits (434), Expect = 3e-42
Identities = 99/277 (35%), Positives = 154/277 (55%), Gaps = 20/277 (7%)
Query: 845 EERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLR-DFEREIEILK 903
+E LK ++ LG G FG+V + P + VA+K L +T +F E I+
Sbjct: 714 KETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMA 773
Query: 904 SLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKG 963
S+ H ++V+ GVC S ++L+ + +P+G L +Y+ +HK+ I LL + QI KG
Sbjct: 774 SMDHPHLVRLLGVCLSP---TIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKG 830
Query: 964 MEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAP 1023
M YL +R +HRDLA RN+LV++ N VKI DFGL ++L D++ Y + G+ PI W A
Sbjct: 831 MMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNA-DGGKMPIKWMAL 889
Query: 1024 ESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLK 1083
E + KF+ SDVWS+GV ++EL T+ G + + +LL+
Sbjct: 890 ECIHYRKFTHQSDVWSYGVTIWELMTF---------------GGKPYDGIPTREIPDLLE 934
Query: 1084 NNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLA 1120
RLP+P C ++YM+M +CW + + RP F++LA
Sbjct: 935 KGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELA 971
Score = 94.0 bits (232), Expect = 7e-19
Identities = 75/295 (25%), Positives = 138/295 (46%), Gaps = 24/295 (8%)
Query: 524 PTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVL 583
P T NQ ++ +L + LG G F ++KG+ G+ ++ V +K+L
Sbjct: 697 PLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKI---PVAIKIL 753
Query: 584 DKAHRNYSE-SFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNK 642
++ + F + A +M+ + H HLV GVC+ LV + + G L Y+ ++K
Sbjct: 754 NETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLEYVHEHK 812
Query: 643 NCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGI 702
+ I L Q+A M +LEE L+H ++ A+N+L+ +P +K++D G+
Sbjct: 813 DNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLV--------KSPNHVKITDFGL 864
Query: 703 SITVLPKDILQER-------IPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLS 755
+ +L D + I W+ ECI K + +D WS+G T+WE+ + G KP
Sbjct: 865 A-RLLEGDEKEYNADGGKMPIKWMALECIHYRKFTH-QSDVWSYGVTIWELMTFGGKPYD 922
Query: 756 ALDSQRKLQFYEDRHQLPAPK--WAELANLINNCMDYEPDFRPSFRAIIRDLNSL 808
+ ++ E +LP P ++ ++ C + D RP F+ + + + +
Sbjct: 923 GIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRM 977
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 170 bits (430), Expect = 8e-42
Identities = 107/292 (36%), Positives = 159/292 (54%), Gaps = 38/292 (13%)
Query: 855 LGKGNFGSV---EMCRYDPLQDNTGEVVAVKKLQH-STEEHLRDFEREIEILKSL-QHDN 909
LG+G FG V E D + N VAVK L+ +TE+ L D E+E++K + +H N
Sbjct: 393 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 452
Query: 910 IVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK---------------ERIDHIKLL 954
I+ G C G L +I+EY G+LR+YLQ + E++ L+
Sbjct: 453 IINLLGACTQDGP--LYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLV 510
Query: 955 QYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPG 1014
Q+ +GMEYL +K+ IHRDLA RN+LV +N +KI DFGL + + +YYK G
Sbjct: 511 SCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI-HHIDYYKKTTNG 569
Query: 1015 ESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMI 1074
P+ W APE+L + ++ SDVWSFGV+L+E+FT +G +
Sbjct: 570 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT---------------LGGSPYPGVP 614
Query: 1075 VFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQI 1126
V L +LLK R+ +P C +E+YM+M +CW+ +QRP+F+ L +D+I
Sbjct: 615 VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 666
Score = 78.2 bits (191), Expect = 4e-14
Identities = 72/325 (22%), Positives = 140/325 (43%), Gaps = 39/325 (12%)
Query: 539 KIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVL--DKAHRNYSESFFE 596
++ + L+ + LG+G F ++ + T+V +K+L D ++ S+ E
Sbjct: 381 ELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISE 440
Query: 597 AASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKN-----CINILWKL 651
M HK+++ G C ++ E+ G+L YL+ + C N
Sbjct: 441 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNP 500
Query: 652 E----------VAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPG 701
E A Q+A M +L IH ++ A+N+L+ + +K++D G
Sbjct: 501 EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN--------VMKIADFG 552
Query: 702 ISITVLPKDILQE----RIP--WVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLS 755
++ + D ++ R+P W+ PE + + + +D WSFG LWEI + G P
Sbjct: 553 LARDIHHIDYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYP 611
Query: 756 ALDSQRKLQFYEDRHQLPAPK--WAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDY 813
+ + + ++ H++ P EL ++ +C P RP+F+ ++ DL+ +
Sbjct: 612 GVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVA--- 668
Query: 814 ELLTENDMLPNMRIGALGFSGAFED 838
LT N ++ + +S +F D
Sbjct: 669 --LTSNQEYLDLSMPLDQYSPSFPD 691
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 170 bits (430), Expect = 8e-42
Identities = 107/292 (36%), Positives = 159/292 (54%), Gaps = 38/292 (13%)
Query: 855 LGKGNFGSV---EMCRYDPLQDNTGEVVAVKKLQH-STEEHLRDFEREIEILKSL-QHDN 909
LG+G FG V E D + N VAVK L+ +TE+ L D E+E++K + +H N
Sbjct: 395 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 454
Query: 910 IVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK---------------ERIDHIKLL 954
I+ G C G L +I+EY G+LR+YLQ + E++ L+
Sbjct: 455 IINLLGACTQDGP--LYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLV 512
Query: 955 QYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPG 1014
Q+ +GMEYL +K+ IHRDLA RN+LV +N +KI DFGL + + +YYK G
Sbjct: 513 SCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI-HHIDYYKKTTNG 571
Query: 1015 ESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMI 1074
P+ W APE+L + ++ SDVWSFGV+L+E+FT +G +
Sbjct: 572 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT---------------LGGSPYPGVP 616
Query: 1075 VFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQI 1126
V L +LLK R+ +P C +E+YM+M +CW+ +QRP+F+ L +D+I
Sbjct: 617 VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 668
Score = 78.2 bits (191), Expect = 4e-14
Identities = 72/325 (22%), Positives = 140/325 (43%), Gaps = 39/325 (12%)
Query: 539 KIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVL--DKAHRNYSESFFE 596
++ + L+ + LG+G F ++ + T+V +K+L D ++ S+ E
Sbjct: 383 ELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISE 442
Query: 597 AASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKN-----CINILWKL 651
M HK+++ G C ++ E+ G+L YL+ + C N
Sbjct: 443 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNP 502
Query: 652 E----------VAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPG 701
E A Q+A M +L IH ++ A+N+L+ + +K++D G
Sbjct: 503 EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN--------VMKIADFG 554
Query: 702 ISITVLPKDILQE----RIP--WVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLS 755
++ + D ++ R+P W+ PE + + + +D WSFG LWEI + G P
Sbjct: 555 LARDIHHIDYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYP 613
Query: 756 ALDSQRKLQFYEDRHQLPAPK--WAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDY 813
+ + + ++ H++ P EL ++ +C P RP+F+ ++ DL+ +
Sbjct: 614 GVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVA--- 670
Query: 814 ELLTENDMLPNMRIGALGFSGAFED 838
LT N ++ + +S +F D
Sbjct: 671 --LTSNQEYLDLSMPLDQYSPSFPD 693
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 170 bits (430), Expect = 8e-42
Identities = 107/292 (36%), Positives = 159/292 (54%), Gaps = 38/292 (13%)
Query: 855 LGKGNFGSV---EMCRYDPLQDNTGEVVAVKKLQH-STEEHLRDFEREIEILKSL-QHDN 909
LG+G FG V E D + N VAVK L+ +TE+ L D E+E++K + +H N
Sbjct: 482 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 541
Query: 910 IVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK---------------ERIDHIKLL 954
I+ G C G L +I+EY G+LR+YLQ + E++ L+
Sbjct: 542 IINLLGACTQDGP--LYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLV 599
Query: 955 QYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPG 1014
Q+ +GMEYL +K+ IHRDLA RN+LV +N +KI DFGL + + +YYK G
Sbjct: 600 SCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI-HHIDYYKKTTNG 658
Query: 1015 ESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMI 1074
P+ W APE+L + ++ SDVWSFGV+L+E+FT +G +
Sbjct: 659 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT---------------LGGSPYPGVP 703
Query: 1075 VFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQI 1126
V L +LLK R+ +P C +E+YM+M +CW+ +QRP+F+ L +D+I
Sbjct: 704 VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 755
Score = 78.2 bits (191), Expect = 4e-14
Identities = 72/325 (22%), Positives = 140/325 (43%), Gaps = 39/325 (12%)
Query: 539 KIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVL--DKAHRNYSESFFE 596
++ + L+ + LG+G F ++ + T+V +K+L D ++ S+ E
Sbjct: 470 ELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISE 529
Query: 597 AASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKN-----CINILWKL 651
M HK+++ G C ++ E+ G+L YL+ + C N
Sbjct: 530 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNP 589
Query: 652 E----------VAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPG 701
E A Q+A M +L IH ++ A+N+L+ + +K++D G
Sbjct: 590 EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN--------VMKIADFG 641
Query: 702 ISITVLPKDILQE----RIP--WVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLS 755
++ + D ++ R+P W+ PE + + + +D WSFG LWEI + G P
Sbjct: 642 LARDIHHIDYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYP 700
Query: 756 ALDSQRKLQFYEDRHQLPAPK--WAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDY 813
+ + + ++ H++ P EL ++ +C P RP+F+ ++ DL+ +
Sbjct: 701 GVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVA--- 757
Query: 814 ELLTENDMLPNMRIGALGFSGAFED 838
LT N ++ + +S +F D
Sbjct: 758 --LTSNQEYLDLSMPLDQYSPSFPD 780
>gi|105990522 fibroblast growth factor receptor 1 isoform 1 precursor
[Homo sapiens]
Length = 822
Score = 170 bits (430), Expect = 8e-42
Identities = 107/292 (36%), Positives = 159/292 (54%), Gaps = 38/292 (13%)
Query: 855 LGKGNFGSV---EMCRYDPLQDNTGEVVAVKKLQH-STEEHLRDFEREIEILKSL-QHDN 909
LG+G FG V E D + N VAVK L+ +TE+ L D E+E++K + +H N
Sbjct: 484 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 543
Query: 910 IVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK---------------ERIDHIKLL 954
I+ G C G L +I+EY G+LR+YLQ + E++ L+
Sbjct: 544 IINLLGACTQDGP--LYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLV 601
Query: 955 QYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPG 1014
Q+ +GMEYL +K+ IHRDLA RN+LV +N +KI DFGL + + +YYK G
Sbjct: 602 SCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI-HHIDYYKKTTNG 660
Query: 1015 ESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMI 1074
P+ W APE+L + ++ SDVWSFGV+L+E+FT +G +
Sbjct: 661 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT---------------LGGSPYPGVP 705
Query: 1075 VFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQI 1126
V L +LLK R+ +P C +E+YM+M +CW+ +QRP+F+ L +D+I
Sbjct: 706 VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 757
Score = 78.2 bits (191), Expect = 4e-14
Identities = 72/325 (22%), Positives = 140/325 (43%), Gaps = 39/325 (12%)
Query: 539 KIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVL--DKAHRNYSESFFE 596
++ + L+ + LG+G F ++ + T+V +K+L D ++ S+ E
Sbjct: 472 ELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISE 531
Query: 597 AASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKN-----CINILWKL 651
M HK+++ G C ++ E+ G+L YL+ + C N
Sbjct: 532 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNP 591
Query: 652 E----------VAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPG 701
E A Q+A M +L IH ++ A+N+L+ + +K++D G
Sbjct: 592 EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN--------VMKIADFG 643
Query: 702 ISITVLPKDILQE----RIP--WVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLS 755
++ + D ++ R+P W+ PE + + + +D WSFG LWEI + G P
Sbjct: 644 LARDIHHIDYYKKTTNGRLPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYP 702
Query: 756 ALDSQRKLQFYEDRHQLPAPK--WAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDY 813
+ + + ++ H++ P EL ++ +C P RP+F+ ++ DL+ +
Sbjct: 703 GVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVA--- 759
Query: 814 ELLTENDMLPNMRIGALGFSGAFED 838
LT N ++ + +S +F D
Sbjct: 760 --LTSNQEYLDLSMPLDQYSPSFPD 782
>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform b
precursor [Homo sapiens]
Length = 825
Score = 168 bits (426), Expect = 2e-41
Identities = 104/293 (35%), Positives = 152/293 (51%), Gaps = 38/293 (12%)
Query: 845 EERHLKFLQQLGKGNFGSV---EMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEI 901
+ R + ++LG+G FG V E P +D +VAVK L+ T +DF+RE E+
Sbjct: 534 KRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKM--LVAVKALKDPTLAARKDFQREAEL 591
Query: 902 LKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKH---------------KE 946
L +LQH++IVK+ GVC L ++ EY+ +G L +L+ H K
Sbjct: 592 LTNLQHEHIVKFYGVCGDGDP--LIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKG 649
Query: 947 RIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKE 1006
+ ++L SQI GM YL ++ ++HRDLATRN LV VKIGDFG+++ + +
Sbjct: 650 ELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDV-YSTD 708
Query: 1007 YYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIG 1066
YY+V PI W PES+ KF+ SDVWSFGV+L+E+FTY G
Sbjct: 709 YYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTY---------------G 753
Query: 1067 NDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 1119
Q+ +IE + L RP CP E+Y +M CW QR + +++
Sbjct: 754 KQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEI 806
Score = 99.4 bits (246), Expect = 2e-20
Identities = 82/312 (26%), Positives = 138/312 (44%), Gaps = 44/312 (14%)
Query: 531 HMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNY 590
H I+ D++ LG+G F K+F + + L T+ + V KA ++
Sbjct: 524 HKPDTYVQHIKRRDIVLKRELGEGAFGKVF------LAECYNLSPTKDKMLVAVKALKDP 577
Query: 591 S----ESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKN----- 641
+ + F A +++ L H+H+V YGVC GD I+V E++K G L+ +L+ +
Sbjct: 578 TLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAM 637
Query: 642 ----------KNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGN 691
K + + L +A Q+A M +L +H ++ +N L+ G
Sbjct: 638 ILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLV--------GA 689
Query: 692 PPFIKLSDPGISITVLPKDILQE------RIPWVPPECIENPKNLNLATDKWSFGTTLWE 745
+K+ D G+S V D + I W+PPE I K +D WSFG LWE
Sbjct: 690 NLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRK-FTTESDVWSFGVILWE 748
Query: 746 ICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWA--ELANLINNCMDYEPDFRPSFRAIIR 803
I + G +P L + ++ L P+ E+ +++ C EP R + + I +
Sbjct: 749 IFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYK 808
Query: 804 DLNSL--FTPDY 813
L++L TP Y
Sbjct: 809 ILHALGKATPIY 820
>gi|222144244 fibroblast growth factor receptor 2 isoform 9 precursor
[Homo sapiens]
Length = 680
Score = 168 bits (425), Expect = 3e-41
Identities = 106/304 (34%), Positives = 163/304 (53%), Gaps = 38/304 (12%)
Query: 843 QFEERHLKFLQQLGKGNFGSVEMCR---YDPLQDNTGEVVAVKKLQH-STEEHLRDFERE 898
+F L + LG+G FG V M D + VAVK L+ +TE+ L D E
Sbjct: 387 EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSE 446
Query: 899 IEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK------------ 945
+E++K + +H NI+ G C G L +I+EY G+LR+YL+ +
Sbjct: 447 MEMMKMIGKHKNIINLLGACTQDGP--LYVIVEYASKGNLREYLRARRPPGMEYSYDINR 504
Query: 946 ---ERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLP 1002
E++ L+ T Q+ +GMEYL +++ IHRDLA RN+LV N +KI DFGL + +
Sbjct: 505 VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI- 563
Query: 1003 QDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFM 1062
+ +YYK G P+ W APE+L + ++ SDVWSFGV+++E+FT
Sbjct: 564 NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT------------- 610
Query: 1063 RMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALR 1122
+G + V L +LLK R+ +P C +E+YM+M +CW+ +QRP+F+ L
Sbjct: 611 --LGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 668
Query: 1123 VDQI 1126
+D+I
Sbjct: 669 LDRI 672
Score = 73.9 bits (180), Expect = 8e-13
Identities = 66/304 (21%), Positives = 128/304 (42%), Gaps = 39/304 (12%)
Query: 543 EDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVL--DKAHRNYSESFFEAASM 600
+ L + LG+G F ++ + V +K+L D ++ S+ E M
Sbjct: 391 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 450
Query: 601 MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNK---------------NCI 645
HK+++ G C ++ E+ G+L YL+ + +
Sbjct: 451 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 510
Query: 646 NILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISIT 705
+ QLA M +L IH ++ A+N+L+ +K++D G++
Sbjct: 511 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN--------VMKIADFGLARD 562
Query: 706 VLPKDILQE----RIP--WVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDS 759
+ D ++ R+P W+ PE + + + +D WSFG +WEI + G P +
Sbjct: 563 INNIDYYKKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV 621
Query: 760 QRKLQFYEDRHQL--PAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLT 817
+ + ++ H++ PA EL ++ +C P RP+F+ ++ DL+ + T LT
Sbjct: 622 EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILT-----LT 676
Query: 818 ENDM 821
N++
Sbjct: 677 TNEI 680
>gi|222144231 fibroblast growth factor receptor 2 isoform 3 precursor
[Homo sapiens]
Length = 769
Score = 168 bits (425), Expect = 3e-41
Identities = 106/304 (34%), Positives = 163/304 (53%), Gaps = 38/304 (12%)
Query: 843 QFEERHLKFLQQLGKGNFGSVEMCR---YDPLQDNTGEVVAVKKLQH-STEEHLRDFERE 898
+F L + LG+G FG V M D + VAVK L+ +TE+ L D E
Sbjct: 476 EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSE 535
Query: 899 IEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK------------ 945
+E++K + +H NI+ G C G L +I+EY G+LR+YL+ +
Sbjct: 536 MEMMKMIGKHKNIINLLGACTQDGP--LYVIVEYASKGNLREYLRARRPPGMEYSYDINR 593
Query: 946 ---ERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLP 1002
E++ L+ T Q+ +GMEYL +++ IHRDLA RN+LV N +KI DFGL + +
Sbjct: 594 VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI- 652
Query: 1003 QDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFM 1062
+ +YYK G P+ W APE+L + ++ SDVWSFGV+++E+FT
Sbjct: 653 NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT------------- 699
Query: 1063 RMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALR 1122
+G + V L +LLK R+ +P C +E+YM+M +CW+ +QRP+F+ L
Sbjct: 700 --LGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 757
Query: 1123 VDQI 1126
+D+I
Sbjct: 758 LDRI 761
Score = 73.9 bits (180), Expect = 8e-13
Identities = 66/304 (21%), Positives = 128/304 (42%), Gaps = 39/304 (12%)
Query: 543 EDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVL--DKAHRNYSESFFEAASM 600
+ L + LG+G F ++ + V +K+L D ++ S+ E M
Sbjct: 480 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 539
Query: 601 MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNK---------------NCI 645
HK+++ G C ++ E+ G+L YL+ + +
Sbjct: 540 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 599
Query: 646 NILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISIT 705
+ QLA M +L IH ++ A+N+L+ +K++D G++
Sbjct: 600 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN--------VMKIADFGLARD 651
Query: 706 VLPKDILQE----RIP--WVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDS 759
+ D ++ R+P W+ PE + + + +D WSFG +WEI + G P +
Sbjct: 652 INNIDYYKKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV 710
Query: 760 QRKLQFYEDRHQL--PAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLT 817
+ + ++ H++ PA EL ++ +C P RP+F+ ++ DL+ + T LT
Sbjct: 711 EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILT-----LT 765
Query: 818 ENDM 821
N++
Sbjct: 766 TNEI 769
>gi|222144241 fibroblast growth factor receptor 2 isoform 8 precursor
[Homo sapiens]
Length = 704
Score = 168 bits (425), Expect = 3e-41
Identities = 106/304 (34%), Positives = 163/304 (53%), Gaps = 38/304 (12%)
Query: 843 QFEERHLKFLQQLGKGNFGSVEMCR---YDPLQDNTGEVVAVKKLQH-STEEHLRDFERE 898
+F L + LG+G FG V M D + VAVK L+ +TE+ L D E
Sbjct: 358 EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSE 417
Query: 899 IEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK------------ 945
+E++K + +H NI+ G C G L +I+EY G+LR+YL+ +
Sbjct: 418 MEMMKMIGKHKNIINLLGACTQDGP--LYVIVEYASKGNLREYLRARRPPGMEYSYDINR 475
Query: 946 ---ERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLP 1002
E++ L+ T Q+ +GMEYL +++ IHRDLA RN+LV N +KI DFGL + +
Sbjct: 476 VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI- 534
Query: 1003 QDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFM 1062
+ +YYK G P+ W APE+L + ++ SDVWSFGV+++E+FT
Sbjct: 535 NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT------------- 581
Query: 1063 RMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALR 1122
+G + V L +LLK R+ +P C +E+YM+M +CW+ +QRP+F+ L
Sbjct: 582 --LGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 639
Query: 1123 VDQI 1126
+D+I
Sbjct: 640 LDRI 643
Score = 73.6 bits (179), Expect = 1e-12
Identities = 63/293 (21%), Positives = 123/293 (41%), Gaps = 34/293 (11%)
Query: 543 EDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVL--DKAHRNYSESFFEAASM 600
+ L + LG+G F ++ + V +K+L D ++ S+ E M
Sbjct: 362 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 421
Query: 601 MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNK---------------NCI 645
HK+++ G C ++ E+ G+L YL+ + +
Sbjct: 422 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 481
Query: 646 NILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISIT 705
+ QLA M +L IH ++ A+N+L+ +K++D G++
Sbjct: 482 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN--------VMKIADFGLARD 533
Query: 706 VLPKDILQE----RIP--WVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDS 759
+ D ++ R+P W+ PE + + + +D WSFG +WEI + G P +
Sbjct: 534 INNIDYYKKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV 592
Query: 760 QRKLQFYEDRHQL--PAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT 810
+ + ++ H++ PA EL ++ +C P RP+F+ ++ DL+ + T
Sbjct: 593 EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILT 645
>gi|222144239 fibroblast growth factor receptor 2 isoform 7 precursor
[Homo sapiens]
Length = 705
Score = 168 bits (425), Expect = 3e-41
Identities = 106/304 (34%), Positives = 163/304 (53%), Gaps = 38/304 (12%)
Query: 843 QFEERHLKFLQQLGKGNFGSVEMCR---YDPLQDNTGEVVAVKKLQH-STEEHLRDFERE 898
+F L + LG+G FG V M D + VAVK L+ +TE+ L D E
Sbjct: 359 EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSE 418
Query: 899 IEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK------------ 945
+E++K + +H NI+ G C G L +I+EY G+LR+YL+ +
Sbjct: 419 MEMMKMIGKHKNIINLLGACTQDGP--LYVIVEYASKGNLREYLRARRPPGMEYSYDINR 476
Query: 946 ---ERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLP 1002
E++ L+ T Q+ +GMEYL +++ IHRDLA RN+LV N +KI DFGL + +
Sbjct: 477 VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI- 535
Query: 1003 QDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFM 1062
+ +YYK G P+ W APE+L + ++ SDVWSFGV+++E+FT
Sbjct: 536 NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT------------- 582
Query: 1063 RMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALR 1122
+G + V L +LLK R+ +P C +E+YM+M +CW+ +QRP+F+ L
Sbjct: 583 --LGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 640
Query: 1123 VDQI 1126
+D+I
Sbjct: 641 LDRI 644
Score = 73.6 bits (179), Expect = 1e-12
Identities = 63/293 (21%), Positives = 123/293 (41%), Gaps = 34/293 (11%)
Query: 543 EDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVL--DKAHRNYSESFFEAASM 600
+ L + LG+G F ++ + V +K+L D ++ S+ E M
Sbjct: 363 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 422
Query: 601 MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNK---------------NCI 645
HK+++ G C ++ E+ G+L YL+ + +
Sbjct: 423 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 482
Query: 646 NILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISIT 705
+ QLA M +L IH ++ A+N+L+ +K++D G++
Sbjct: 483 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN--------VMKIADFGLARD 534
Query: 706 VLPKDILQE----RIP--WVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDS 759
+ D ++ R+P W+ PE + + + +D WSFG +WEI + G P +
Sbjct: 535 INNIDYYKKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV 593
Query: 760 QRKLQFYEDRHQL--PAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT 810
+ + ++ H++ PA EL ++ +C P RP+F+ ++ DL+ + T
Sbjct: 594 EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILT 646
>gi|222144237 fibroblast growth factor receptor 2 isoform 6 precursor
[Homo sapiens]
Length = 706
Score = 168 bits (425), Expect = 3e-41
Identities = 106/304 (34%), Positives = 163/304 (53%), Gaps = 38/304 (12%)
Query: 843 QFEERHLKFLQQLGKGNFGSVEMCR---YDPLQDNTGEVVAVKKLQH-STEEHLRDFERE 898
+F L + LG+G FG V M D + VAVK L+ +TE+ L D E
Sbjct: 360 EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSE 419
Query: 899 IEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK------------ 945
+E++K + +H NI+ G C G L +I+EY G+LR+YL+ +
Sbjct: 420 MEMMKMIGKHKNIINLLGACTQDGP--LYVIVEYASKGNLREYLRARRPPGMEYSYDINR 477
Query: 946 ---ERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLP 1002
E++ L+ T Q+ +GMEYL +++ IHRDLA RN+LV N +KI DFGL + +
Sbjct: 478 VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI- 536
Query: 1003 QDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFM 1062
+ +YYK G P+ W APE+L + ++ SDVWSFGV+++E+FT
Sbjct: 537 NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT------------- 583
Query: 1063 RMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALR 1122
+G + V L +LLK R+ +P C +E+YM+M +CW+ +QRP+F+ L
Sbjct: 584 --LGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 641
Query: 1123 VDQI 1126
+D+I
Sbjct: 642 LDRI 645
Score = 73.6 bits (179), Expect = 1e-12
Identities = 63/293 (21%), Positives = 123/293 (41%), Gaps = 34/293 (11%)
Query: 543 EDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVL--DKAHRNYSESFFEAASM 600
+ L + LG+G F ++ + V +K+L D ++ S+ E M
Sbjct: 364 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 423
Query: 601 MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNK---------------NCI 645
HK+++ G C ++ E+ G+L YL+ + +
Sbjct: 424 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 483
Query: 646 NILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISIT 705
+ QLA M +L IH ++ A+N+L+ +K++D G++
Sbjct: 484 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN--------VMKIADFGLARD 535
Query: 706 VLPKDILQE----RIP--WVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDS 759
+ D ++ R+P W+ PE + + + +D WSFG +WEI + G P +
Sbjct: 536 INNIDYYKKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV 594
Query: 760 QRKLQFYEDRHQL--PAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT 810
+ + ++ H++ PA EL ++ +C P RP+F+ ++ DL+ + T
Sbjct: 595 EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILT 647
>gi|222144235 fibroblast growth factor receptor 2 isoform 5 precursor
[Homo sapiens]
Length = 707
Score = 168 bits (425), Expect = 3e-41
Identities = 106/304 (34%), Positives = 163/304 (53%), Gaps = 38/304 (12%)
Query: 843 QFEERHLKFLQQLGKGNFGSVEMCR---YDPLQDNTGEVVAVKKLQH-STEEHLRDFERE 898
+F L + LG+G FG V M D + VAVK L+ +TE+ L D E
Sbjct: 386 EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSE 445
Query: 899 IEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK------------ 945
+E++K + +H NI+ G C G L +I+EY G+LR+YL+ +
Sbjct: 446 MEMMKMIGKHKNIINLLGACTQDGP--LYVIVEYASKGNLREYLRARRPPGMEYSYDINR 503
Query: 946 ---ERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLP 1002
E++ L+ T Q+ +GMEYL +++ IHRDLA RN+LV N +KI DFGL + +
Sbjct: 504 VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI- 562
Query: 1003 QDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFM 1062
+ +YYK G P+ W APE+L + ++ SDVWSFGV+++E+FT
Sbjct: 563 NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT------------- 609
Query: 1063 RMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALR 1122
+G + V L +LLK R+ +P C +E+YM+M +CW+ +QRP+F+ L
Sbjct: 610 --LGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 667
Query: 1123 VDQI 1126
+D+I
Sbjct: 668 LDRI 671
Score = 73.6 bits (179), Expect = 1e-12
Identities = 63/293 (21%), Positives = 123/293 (41%), Gaps = 34/293 (11%)
Query: 543 EDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVL--DKAHRNYSESFFEAASM 600
+ L + LG+G F ++ + V +K+L D ++ S+ E M
Sbjct: 390 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 449
Query: 601 MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNK---------------NCI 645
HK+++ G C ++ E+ G+L YL+ + +
Sbjct: 450 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 509
Query: 646 NILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISIT 705
+ QLA M +L IH ++ A+N+L+ +K++D G++
Sbjct: 510 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN--------VMKIADFGLARD 561
Query: 706 VLPKDILQE----RIP--WVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDS 759
+ D ++ R+P W+ PE + + + +D WSFG +WEI + G P +
Sbjct: 562 INNIDYYKKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV 620
Query: 760 QRKLQFYEDRHQL--PAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT 810
+ + ++ H++ PA EL ++ +C P RP+F+ ++ DL+ + T
Sbjct: 621 EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILT 673
>gi|222144233 fibroblast growth factor receptor 2 isoform 4 precursor
[Homo sapiens]
Length = 709
Score = 168 bits (425), Expect = 3e-41
Identities = 106/304 (34%), Positives = 163/304 (53%), Gaps = 38/304 (12%)
Query: 843 QFEERHLKFLQQLGKGNFGSVEMCR---YDPLQDNTGEVVAVKKLQH-STEEHLRDFERE 898
+F L + LG+G FG V M D + VAVK L+ +TE+ L D E
Sbjct: 363 EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSE 422
Query: 899 IEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK------------ 945
+E++K + +H NI+ G C G L +I+EY G+LR+YL+ +
Sbjct: 423 MEMMKMIGKHKNIINLLGACTQDGP--LYVIVEYASKGNLREYLRARRPPGMEYSYDINR 480
Query: 946 ---ERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLP 1002
E++ L+ T Q+ +GMEYL +++ IHRDLA RN+LV N +KI DFGL + +
Sbjct: 481 VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI- 539
Query: 1003 QDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFM 1062
+ +YYK G P+ W APE+L + ++ SDVWSFGV+++E+FT
Sbjct: 540 NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT------------- 586
Query: 1063 RMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALR 1122
+G + V L +LLK R+ +P C +E+YM+M +CW+ +QRP+F+ L
Sbjct: 587 --LGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 644
Query: 1123 VDQI 1126
+D+I
Sbjct: 645 LDRI 648
Score = 73.6 bits (179), Expect = 1e-12
Identities = 63/293 (21%), Positives = 123/293 (41%), Gaps = 34/293 (11%)
Query: 543 EDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVL--DKAHRNYSESFFEAASM 600
+ L + LG+G F ++ + V +K+L D ++ S+ E M
Sbjct: 367 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 426
Query: 601 MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNK---------------NCI 645
HK+++ G C ++ E+ G+L YL+ + +
Sbjct: 427 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 486
Query: 646 NILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISIT 705
+ QLA M +L IH ++ A+N+L+ +K++D G++
Sbjct: 487 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN--------VMKIADFGLARD 538
Query: 706 VLPKDILQE----RIP--WVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDS 759
+ D ++ R+P W+ PE + + + +D WSFG +WEI + G P +
Sbjct: 539 INNIDYYKKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV 597
Query: 760 QRKLQFYEDRHQL--PAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT 810
+ + ++ H++ PA EL ++ +C P RP+F+ ++ DL+ + T
Sbjct: 598 EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILT 650
>gi|221316639 fibroblast growth factor receptor 2 isoform 1 precursor
[Homo sapiens]
Length = 821
Score = 168 bits (425), Expect = 3e-41
Identities = 106/304 (34%), Positives = 163/304 (53%), Gaps = 38/304 (12%)
Query: 843 QFEERHLKFLQQLGKGNFGSVEMCR---YDPLQDNTGEVVAVKKLQH-STEEHLRDFERE 898
+F L + LG+G FG V M D + VAVK L+ +TE+ L D E
Sbjct: 475 EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSE 534
Query: 899 IEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK------------ 945
+E++K + +H NI+ G C G L +I+EY G+LR+YL+ +
Sbjct: 535 MEMMKMIGKHKNIINLLGACTQDGP--LYVIVEYASKGNLREYLRARRPPGMEYSYDINR 592
Query: 946 ---ERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLP 1002
E++ L+ T Q+ +GMEYL +++ IHRDLA RN+LV N +KI DFGL + +
Sbjct: 593 VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI- 651
Query: 1003 QDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFM 1062
+ +YYK G P+ W APE+L + ++ SDVWSFGV+++E+FT
Sbjct: 652 NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT------------- 698
Query: 1063 RMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALR 1122
+G + V L +LLK R+ +P C +E+YM+M +CW+ +QRP+F+ L
Sbjct: 699 --LGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 756
Query: 1123 VDQI 1126
+D+I
Sbjct: 757 LDRI 760
Score = 73.6 bits (179), Expect = 1e-12
Identities = 63/293 (21%), Positives = 123/293 (41%), Gaps = 34/293 (11%)
Query: 543 EDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVL--DKAHRNYSESFFEAASM 600
+ L + LG+G F ++ + V +K+L D ++ S+ E M
Sbjct: 479 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 538
Query: 601 MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNK---------------NCI 645
HK+++ G C ++ E+ G+L YL+ + +
Sbjct: 539 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 598
Query: 646 NILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISIT 705
+ QLA M +L IH ++ A+N+L+ +K++D G++
Sbjct: 599 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN--------VMKIADFGLARD 650
Query: 706 VLPKDILQE----RIP--WVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDS 759
+ D ++ R+P W+ PE + + + +D WSFG +WEI + G P +
Sbjct: 651 INNIDYYKKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV 709
Query: 760 QRKLQFYEDRHQL--PAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT 810
+ + ++ H++ PA EL ++ +C P RP+F+ ++ DL+ + T
Sbjct: 710 EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILT 762
>gi|221316638 fibroblast growth factor receptor 2 isoform 2 precursor
[Homo sapiens]
Length = 822
Score = 168 bits (425), Expect = 3e-41
Identities = 106/304 (34%), Positives = 163/304 (53%), Gaps = 38/304 (12%)
Query: 843 QFEERHLKFLQQLGKGNFGSVEMCR---YDPLQDNTGEVVAVKKLQH-STEEHLRDFERE 898
+F L + LG+G FG V M D + VAVK L+ +TE+ L D E
Sbjct: 476 EFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSE 535
Query: 899 IEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK------------ 945
+E++K + +H NI+ G C G L +I+EY G+LR+YL+ +
Sbjct: 536 MEMMKMIGKHKNIINLLGACTQDGP--LYVIVEYASKGNLREYLRARRPPGMEYSYDINR 593
Query: 946 ---ERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLP 1002
E++ L+ T Q+ +GMEYL +++ IHRDLA RN+LV N +KI DFGL + +
Sbjct: 594 VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI- 652
Query: 1003 QDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFM 1062
+ +YYK G P+ W APE+L + ++ SDVWSFGV+++E+FT
Sbjct: 653 NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT------------- 699
Query: 1063 RMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALR 1122
+G + V L +LLK R+ +P C +E+YM+M +CW+ +QRP+F+ L
Sbjct: 700 --LGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 757
Query: 1123 VDQI 1126
+D+I
Sbjct: 758 LDRI 761
Score = 73.6 bits (179), Expect = 1e-12
Identities = 63/293 (21%), Positives = 123/293 (41%), Gaps = 34/293 (11%)
Query: 543 EDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVL--DKAHRNYSESFFEAASM 600
+ L + LG+G F ++ + V +K+L D ++ S+ E M
Sbjct: 480 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 539
Query: 601 MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNK---------------NCI 645
HK+++ G C ++ E+ G+L YL+ + +
Sbjct: 540 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 599
Query: 646 NILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISIT 705
+ QLA M +L IH ++ A+N+L+ +K++D G++
Sbjct: 600 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN--------VMKIADFGLARD 651
Query: 706 VLPKDILQE----RIP--WVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDS 759
+ D ++ R+P W+ PE + + + +D WSFG +WEI + G P +
Sbjct: 652 INNIDYYKKTTNGRLPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPV 710
Query: 760 QRKLQFYEDRHQL--PAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFT 810
+ + ++ H++ PA EL ++ +C P RP+F+ ++ DL+ + T
Sbjct: 711 EELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILT 763
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
sapiens]
Length = 1070
Score = 168 bits (425), Expect = 3e-41
Identities = 99/314 (31%), Positives = 160/314 (50%), Gaps = 27/314 (8%)
Query: 816 LTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNT 875
+ E L ++ G + D F L+ + LGK FG V + + L++
Sbjct: 763 IQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGV 822
Query: 876 GE-VVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPY 934
E +V VK LQ E+ DF RE+E+ L H N+V+ G+C A + ++EY+
Sbjct: 823 AETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYM--VLEYVDL 880
Query: 935 GSLRDYLQKHKERIDHIKL--------LQYTSQICKGMEYLGTKRYIHRDLATRNILVEN 986
G L+ +L+ K + + +K + +Q+ GME+L R++H+DLA RN LV
Sbjct: 881 GDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSA 940
Query: 987 ENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYE 1046
+ +VK+ GL+K + + EYY ++ P+ W +PE++ E FS SDVW+FGV+++E
Sbjct: 941 QRQVKVSALGLSKDV-YNSEYYHFRQ-AWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWE 998
Query: 1047 LFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECW 1106
+FT+ E GQ L +L RLP+P+GCP ++Y +M CW
Sbjct: 999 VFTHGEMPHG--------------GQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCW 1044
Query: 1107 NNNVNQRPSFRDLA 1120
+ RPSF ++A
Sbjct: 1045 ALSPKDRPSFSEIA 1058
Score = 85.1 bits (209), Expect = 3e-16
Identities = 69/268 (25%), Positives = 119/268 (44%), Gaps = 27/268 (10%)
Query: 550 SLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHL 609
+LG+ F ++F + + G + ET VL+K L F M KL+H ++
Sbjct: 801 TLGKSEFGEVF--LAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANV 858
Query: 610 VLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKN--------CINILWKLEVAKQLAWAM 661
V G+C + + +V E+V G L +L+ +K+ ++ K+ + Q+A M
Sbjct: 859 VRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGM 918
Query: 662 HFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP- 720
L N +H ++ A+N L+ + +K+S G+S V + R WVP
Sbjct: 919 EHLSNNRFVHKDLAARNCLVSAQRQ--------VKVSALGLSKDVYNSEYYHFRQAWVPL 970
Query: 721 ----PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSA-LDSQRKLQFYEDRHQLPAP 775
PE I + + +D W+FG +WE+ + G+ P D + + +LP P
Sbjct: 971 RWMSPEAILE-GDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQP 1029
Query: 776 KW--AELANLINNCMDYEPDFRPSFRAI 801
+ ++L L+ C P RPSF I
Sbjct: 1030 EGCPSKLYRLMQRCWALSPKDRPSFSEI 1057
>gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [Homo
sapiens]
Length = 1014
Score = 168 bits (425), Expect = 3e-41
Identities = 99/314 (31%), Positives = 160/314 (50%), Gaps = 27/314 (8%)
Query: 816 LTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNT 875
+ E L ++ G + D F L+ + LGK FG V + + L++
Sbjct: 707 IQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGV 766
Query: 876 GE-VVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPY 934
E +V VK LQ E+ DF RE+E+ L H N+V+ G+C A + ++EY+
Sbjct: 767 AETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYM--VLEYVDL 824
Query: 935 GSLRDYLQKHKERIDHIKL--------LQYTSQICKGMEYLGTKRYIHRDLATRNILVEN 986
G L+ +L+ K + + +K + +Q+ GME+L R++H+DLA RN LV
Sbjct: 825 GDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSA 884
Query: 987 ENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYE 1046
+ +VK+ GL+K + + EYY ++ P+ W +PE++ E FS SDVW+FGV+++E
Sbjct: 885 QRQVKVSALGLSKDV-YNSEYYHFRQ-AWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWE 942
Query: 1047 LFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECW 1106
+FT+ E GQ L +L RLP+P+GCP ++Y +M CW
Sbjct: 943 VFTHGEMPHG--------------GQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCW 988
Query: 1107 NNNVNQRPSFRDLA 1120
+ RPSF ++A
Sbjct: 989 ALSPKDRPSFSEIA 1002
Score = 85.1 bits (209), Expect = 3e-16
Identities = 69/268 (25%), Positives = 119/268 (44%), Gaps = 27/268 (10%)
Query: 550 SLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHL 609
+LG+ F ++F + + G + ET VL+K L F M KL+H ++
Sbjct: 745 TLGKSEFGEVF--LAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANV 802
Query: 610 VLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKN--------CINILWKLEVAKQLAWAM 661
V G+C + + +V E+V G L +L+ +K+ ++ K+ + Q+A M
Sbjct: 803 VRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGM 862
Query: 662 HFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP- 720
L N +H ++ A+N L+ + +K+S G+S V + R WVP
Sbjct: 863 EHLSNNRFVHKDLAARNCLVSAQRQ--------VKVSALGLSKDVYNSEYYHFRQAWVPL 914
Query: 721 ----PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSA-LDSQRKLQFYEDRHQLPAP 775
PE I + + +D W+FG +WE+ + G+ P D + + +LP P
Sbjct: 915 RWMSPEAILE-GDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQP 973
Query: 776 KW--AELANLINNCMDYEPDFRPSFRAI 801
+ ++L L+ C P RPSF I
Sbjct: 974 EGCPSKLYRLMQRCWALSPKDRPSFSEI 1001
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,016,615
Number of Sequences: 37866
Number of extensions: 2004569
Number of successful extensions: 7586
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 607
Number of HSP's successfully gapped in prelim test: 200
Number of HSP's that attempted gapping in prelim test: 4112
Number of HSP's gapped (non-prelim): 1612
length of query: 1132
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1019
effective length of database: 13,968,660
effective search space: 14234064540
effective search space used: 14234064540
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.