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Search of human proteins with 4759050
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3
[Homo sapiens]
(740 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 1491 0.0
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 1209 0.0
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 1194 0.0
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 1191 0.0
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 1172 0.0
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 1152 0.0
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 560 e-159
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 540 e-153
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 538 e-153
gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b... 427 e-119
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 377 e-104
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 365 e-101
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 292 7e-79
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 292 7e-79
gi|4502023 AKT2 kinase [Homo sapiens] 290 3e-78
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 284 2e-76
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 284 2e-76
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 284 2e-76
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 284 2e-76
gi|62241015 AKT1 kinase [Homo sapiens] 284 2e-76
gi|62241013 AKT1 kinase [Homo sapiens] 284 2e-76
gi|62241011 AKT1 kinase [Homo sapiens] 284 2e-76
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 278 1e-74
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 278 1e-74
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 270 5e-72
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 270 5e-72
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 264 3e-70
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 260 3e-69
gi|5453974 protein kinase N2 [Homo sapiens] 257 3e-68
gi|4506067 protein kinase C, alpha [Homo sapiens] 256 5e-68
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 1491 bits (3860), Expect = 0.0
Identities = 740/740 (100%), Positives = 740/740 (100%)
Query: 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGH 60
MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGH
Sbjct: 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGH 60
Query: 61 EKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERD 120
EKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERD
Sbjct: 61 EKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERD 120
Query: 121 ILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180
ILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA
Sbjct: 121 ILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180
Query: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 240
LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV
Sbjct: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 240
Query: 241 NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLR 300
NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLR
Sbjct: 241 NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLR 300
Query: 301 MLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPE 360
MLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPE
Sbjct: 301 MLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPE 360
Query: 361 FTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTD 420
FTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTD
Sbjct: 361 FTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTD 420
Query: 421 GYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLK 480
GYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLK
Sbjct: 421 GYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLK 480
Query: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540
DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL
Sbjct: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540
Query: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD 600
KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD
Sbjct: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD 600
Query: 601 IWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKML 660
IWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKML
Sbjct: 601 IWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKML 660
Query: 661 HVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEP 720
HVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEP
Sbjct: 661 HVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEP 720
Query: 721 VGRSTLAQRRGIKKITSTAL 740
VGRSTLAQRRGIKKITSTAL
Sbjct: 721 VGRSTLAQRRGIKKITSTAL 740
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 1209 bits (3128), Expect = 0.0
Identities = 602/744 (80%), Positives = 664/744 (89%), Gaps = 7/744 (0%)
Query: 1 MPLAQLADPWQKMAVESPS-DSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEG 59
MP+AQL + W+K+ VE ++ E + EP E+ + EE +KEI I+HHVKEG
Sbjct: 1 MPIAQLLELWKKIEVEPMEIETTEEDLNLDVEPTTED--TAEEEEGVVKEIDISHHVKEG 58
Query: 60 HEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMER 119
EKADPSQFELLKVLGQGS+GKVFLV+K+ GSDA QLYAMKVLKKATLKVRDRVR+KMER
Sbjct: 59 FEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMER 118
Query: 120 DILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 179
DIL EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL
Sbjct: 119 DILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 178
Query: 180 ALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEV 239
ALDHLHSLGIIYRDLKPENILLDEEGHIK+TDFGLSKE+IDH+K+AYSFCGT+EYMAPEV
Sbjct: 179 ALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEV 238
Query: 240 VNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLL 299
VNRRGHTQSADWWSFGVLMFEMLTG+LPFQGKDRKETM +ILKAKLGMPQFLS EAQSLL
Sbjct: 239 VNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLL 298
Query: 300 RMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDP 359
R LFKRNP NRLGAG DGVEEIKRH FF TIDWN LYR+EI PPFKPA GRPEDTF+FDP
Sbjct: 299 RALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDP 358
Query: 360 EFTAKTPKDSPGIPPSANAHQLFRGFSFVA--ITSDDESQAMQTVGVHSIVQQLHRNSIQ 417
EFTA+TP DSPG+PPSANAH LFRGFSFVA + + Q + V VH IVQQLH N+I
Sbjct: 359 EFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIH 418
Query: 418 FTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNII 477
FTDGYE+KEDIGVGSYSVCKRC+HKAT+ E+AVKIIDKSKRDP+EEIEILLRYGQHPNII
Sbjct: 419 FTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNII 478
Query: 478 TLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVH 537
TLKDVYDDGK+VY+V ELM+GGELLD+ILRQ++FSEREAS VL TITKT++YLH+QGVVH
Sbjct: 479 TLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVH 538
Query: 538 RDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDA 597
RDLKPSNILY DESG+PESIR+CDFGFAKQLRA NGLLMTPCYTANFVAPEVLKRQGYDA
Sbjct: 539 RDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDA 598
Query: 598 ACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVS 657
ACDIWSLG+LLYTML G+TPFANGPDDTPEEILARIGSGK++LSGG W+S+SD AKD+VS
Sbjct: 599 ACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVS 658
Query: 658 KMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRN-QSP 716
KMLHVDPHQRLTA VL+HPW+V+ + L QL+RQD HLVKGAMAATY ALNR Q+P
Sbjct: 659 KMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQDV-HLVKGAMAATYFALNRTPQAP 717
Query: 717 VLEPVGRSTLAQRRGIKKITSTAL 740
LEPV S LAQRRG+K++TST L
Sbjct: 718 RLEPVLSSNLAQRRGMKRLTSTRL 741
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 1194 bits (3088), Expect = 0.0
Identities = 589/701 (84%), Positives = 642/701 (91%), Gaps = 4/701 (0%)
Query: 43 EEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVL 102
EE +KEI I+HHVKEG EKADPSQFELLKVLGQGS+GKVFLV+K+ GSDA QLYAMKVL
Sbjct: 34 EEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVL 93
Query: 103 KKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKE 162
KKATLKVRDRVR+KMERDIL EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKE
Sbjct: 94 KKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKE 153
Query: 163 VMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHE 222
VMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIK+TDFGLSKE+IDH+
Sbjct: 154 VMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHD 213
Query: 223 KKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILK 282
K+AYSFCGT+EYMAPEVVNRRGHTQSADWWSFGVLMFEMLTG+LPFQGKDRKETM +ILK
Sbjct: 214 KRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILK 273
Query: 283 AKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHP 342
AKLGMPQFLS EAQSLLR LFKRNP NRLGAG DGVEEIKRH FF TIDWN LYR+EI P
Sbjct: 274 AKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKP 333
Query: 343 PFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVA--ITSDDESQAMQ 400
PFKPA GRPEDTF+FDPEFTA+TP DSPG+PPSANAH LFRGFSFVA + + Q +
Sbjct: 334 PFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLH 393
Query: 401 TVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDP 460
V VH IVQQLH N+I FTDGYE+KEDIGVGSYSVCKRC+HKAT+ E+AVKIIDKSKRDP
Sbjct: 394 KVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDP 453
Query: 461 TEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVL 520
+EEIEILLRYGQHPNIITLKDVYDDGK+VY+V ELM+GGELLD+ILRQ++FSEREAS VL
Sbjct: 454 SEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVL 513
Query: 521 FTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCY 580
TITKT++YLH+QGVVHRDLKPSNILY DESG+PESIR+CDFGFAKQLRA NGLLMTPCY
Sbjct: 514 CTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCY 573
Query: 581 TANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSL 640
TANFVAPEVLKRQGYDAACDIWSLG+LLYTML G+TPFANGPDDTPEEILARIGSGK++L
Sbjct: 574 TANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYAL 633
Query: 641 SGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVK 700
SGG W+S+SD AKD+VSKMLHVDPHQRLTA VL+HPW+V+ + L QL+RQD HLVK
Sbjct: 634 SGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQDV-HLVK 692
Query: 701 GAMAATYSALNRN-QSPVLEPVGRSTLAQRRGIKKITSTAL 740
GAMAATY ALNR Q+P LEPV S LAQRRG+K++TST L
Sbjct: 693 GAMAATYFALNRTPQAPRLEPVLSSNLAQRRGMKRLTSTRL 733
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 1191 bits (3081), Expect = 0.0
Identities = 599/744 (80%), Positives = 654/744 (87%), Gaps = 13/744 (1%)
Query: 1 MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEE-INPQTEEVSIKEIAITHHVKEG 59
MPLAQL +PW M + P D ENGQ GEE + P +E +KEI+ITHHVK G
Sbjct: 1 MPLAQLKEPWPLMELV-PLDP-ENGQT-----SGEEAGLQPSKDEGVLKEISITHHVKAG 53
Query: 60 HEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMER 119
EKADPS FELLKVLGQGSFGKVFLV+K++ D+ LYAMKVLKKATLKVRDRVRTKMER
Sbjct: 54 SEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMER 113
Query: 120 DILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 179
DIL +VNHPF+VKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL
Sbjct: 114 DILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 173
Query: 180 ALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEV 239
LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKE+IDHEKKAYSFCGTVEYMAPEV
Sbjct: 174 GLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEV 233
Query: 240 VNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLL 299
VNR+GH+ SADWWS+GVLMFEMLTG+LPFQGKDRKETMT+ILKAKLGMPQFLS EAQSLL
Sbjct: 234 VNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLL 293
Query: 300 RMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDP 359
R LFKRNPANRLG+GPDG EEIKRH F+STIDWNKLYRREI PPFKPA +P+DTFYFD
Sbjct: 294 RALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDT 353
Query: 360 EFTAKTPKDSPGIPPSANAHQLFRGFSFVA--ITSDDESQAMQTVGVHSIVQQLHRNSIQ 417
EFT++TPKDSPGIPPSA AHQLFRGFSFVA + DD +HS+VQQLH ++
Sbjct: 354 EFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRAPQAPLHSVVQQLHGKNLV 413
Query: 418 FTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNII 477
F+DGY VKE IGVGSYS CKRC+HKATNME+AVK+IDKSKRDP+EEIEILLRYGQHPNII
Sbjct: 414 FSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNII 473
Query: 478 TLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVH 537
TLKDVYDDGK+VY+VTELM+GGELLDKILRQKFFSEREAS VL TI KTVEYLH+QGVVH
Sbjct: 474 TLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVH 533
Query: 538 RDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDA 597
RDLKPSNILYVDESGNPE +RICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYD
Sbjct: 534 RDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDE 593
Query: 598 ACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVS 657
CDIWSLG+LLYTML GYTPFANGP DTPEEIL RIGSGKF+LSGG WN+VS+TAKDLVS
Sbjct: 594 GCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVS 653
Query: 658 KMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQ-SP 716
KMLHVDPHQRLTA VL+HPW+ D+LPQ QL+ QD LVKGAMAATYSALN ++ +P
Sbjct: 654 KMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDL-QLVKGAMAATYSALNSSKPTP 712
Query: 717 VLEPVGRSTLAQRRGIKKITSTAL 740
L+P+ S LAQRR ++K+ ST L
Sbjct: 713 QLKPIESSILAQRR-VRKLPSTTL 735
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 1172 bits (3033), Expect = 0.0
Identities = 580/702 (82%), Positives = 633/702 (90%), Gaps = 5/702 (0%)
Query: 42 TEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKV 101
++E +KEI+ITHHVK G EKADPS FELLKVLGQGSFGKVFLV+K++ D+ LYAMKV
Sbjct: 45 SDEGVLKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKV 104
Query: 102 LKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK 161
LKKATLKVRDRVRTKMERDIL +VNHPF+VKLHYAFQTEGKLYLILDFLRGGDLFTRLSK
Sbjct: 105 LKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK 164
Query: 162 EVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDH 221
EVMFTEEDVKFYLAELAL LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKE+IDH
Sbjct: 165 EVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDH 224
Query: 222 EKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMIL 281
EKKAYSFCGTVEYMAPEVVNR+GH+ SADWWS+GVLMFEMLTG+LPFQGKDRKETMT+IL
Sbjct: 225 EKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLIL 284
Query: 282 KAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIH 341
KAKLGMPQFLS EAQSLLR LFKRNPANRLG+GPDG EEIKRH F+STIDWNKLYRREI
Sbjct: 285 KAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIK 344
Query: 342 PPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVA--ITSDDESQAM 399
PPFKPA +P+DTFYFD EFT++TPKDSPGIPPSA AHQLFRGFSFVA + DD
Sbjct: 345 PPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGKPRA 404
Query: 400 QTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRD 459
+HS+VQQLH ++ F+DGY VKE IGVGSYS CKRC+HKATNME+AVK+IDKSKRD
Sbjct: 405 PQAPLHSVVQQLHGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRD 464
Query: 460 PTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAV 519
P+EEIEILLRYGQHPNIITLKDVYDDGK+VY+VTELM+GGELLDKILRQKFFSEREAS V
Sbjct: 465 PSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFV 524
Query: 520 LFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPC 579
L TI KTVEYLH+QGVVHRDLKPSNILYVDESGNPE +RICDFGFAKQLRAENGLLMTPC
Sbjct: 525 LHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPC 584
Query: 580 YTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFS 639
YTANFVAPEVLKRQGYD CDIWSLG+LLYTML GYTPFANGP DTPEEIL RIGSGKF+
Sbjct: 585 YTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFT 644
Query: 640 LSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLV 699
LSGG WN+VS+TAKDLVSKMLHVDPHQRLTA VL+HPW+ D+LPQ QL+ QD LV
Sbjct: 645 LSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDL-QLV 703
Query: 700 KGAMAATYSALNRNQ-SPVLEPVGRSTLAQRRGIKKITSTAL 740
KGAMAATYSALN ++ +P L+P+ S LAQRR ++K+ ST L
Sbjct: 704 KGAMAATYSALNSSKPTPQLKPIESSILAQRR-VRKLPSTTL 744
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 1152 bits (2981), Expect = 0.0
Identities = 574/746 (76%), Positives = 647/746 (86%), Gaps = 8/746 (1%)
Query: 1 MPLAQLADPWQK-MAVES---PSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHV 56
+P A +PW + M V S S NG +++DEPM E E + +E +KEI ITHHV
Sbjct: 2 LPFAPQDEPWDREMEVFSGGGASSGEVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHHV 61
Query: 57 KEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTK 116
KEG+EKADP+QFELLKVLGQGSFGKVFLV+K +G DA QLYAMKVLKKA+LKVRDRVRTK
Sbjct: 62 KEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTK 121
Query: 117 MERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAE 176
MERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGD+FTRLSKEV+FTEEDVKFYLAE
Sbjct: 122 MERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAE 181
Query: 177 LALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMA 236
LALALDHLH LGI+YRDLKPENILLDE GHIKLTDFGLSKES+D EKKAYSFCGTVEYMA
Sbjct: 182 LALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMA 241
Query: 237 PEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQ 296
PEVVNRRGH+QSADWWS+GVLMFEMLTGTLPFQGKDR ETM MILKAKLGMPQFLS EAQ
Sbjct: 242 PEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQ 301
Query: 297 SLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFY 356
SLLRMLFKRNPANRLG+ +GVEEIKRH FF+ IDW+KLY+RE+ PPFKPA+G+P+DTF
Sbjct: 302 SLLRMLFKRNPANRLGS--EGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFC 359
Query: 357 FDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSI-VQQLHRNS 415
FDPEFTAKTPKDSPG+P SANAHQLF+GFSFVA + +E + + + + Q++ N+
Sbjct: 360 FDPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQINGNA 419
Query: 416 IQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPN 475
QF + YE+KEDIGVGSYSVCKRCIH TNMEFAVKIIDKSKRDP+EEIEIL+RYGQHPN
Sbjct: 420 AQFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPN 479
Query: 476 IITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGV 535
IITLKDV+DDG+YVY+VT+LMKGGELLD+IL+QK FSEREAS +L+ I+KTV+YLH QGV
Sbjct: 480 IITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGV 539
Query: 536 VHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGY 595
VHRDLKPSNILY+DES + +SIRICDFGFAKQLR ENGLL+TPCYTANFVAPEVL +QGY
Sbjct: 540 VHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGY 599
Query: 596 DAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDL 655
DAACDIWSLGVL YTML GYTPFANGP+DTPEEIL RIG+GKFSLSGG W+++SD AKDL
Sbjct: 600 DAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDL 659
Query: 656 VSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSAL-NRNQ 714
+S MLH+DPHQR TA +L+H WI H DQLP Q R D H+VKGAM ATYSAL ++
Sbjct: 660 LSHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTF 719
Query: 715 SPVLEPVGRSTLAQRRGIKKITSTAL 740
PVLEPV S+LAQRR +KK TST L
Sbjct: 720 QPVLEPVAASSLAQRRSMKKRTSTGL 745
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 560 bits (1442), Expect = e-159
Identities = 321/761 (42%), Positives = 455/761 (59%), Gaps = 54/761 (7%)
Query: 14 AVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKV 73
A + +D + G+Q++ T + ++ +T H EK FELLKV
Sbjct: 11 AAGTSADGGDGGEQLL------------TVKHELRTANLTGHA----EKVGIENFELLKV 54
Query: 74 LGQGSFGKVFLVKKISGSDARQLYAMKVLKKATL--KVRDRVRTKMERDILVEVNH-PFI 130
LG G++GKVFLV+KISG D +LYAMKVLKKAT+ K + T+ ER +L + PF+
Sbjct: 55 LGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFL 114
Query: 131 VKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGII 190
V LHYAFQTE KL+LILD++ GG+LFT LS+ FTE +V+ Y+ E+ LAL+HLH LGII
Sbjct: 115 VTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGII 174
Query: 191 YRDLKPENILLDEEGHIKLTDFGLSKESI-DHEKKAYSFCGTVEYMAPEVV--NRRGHTQ 247
YRD+K ENILLD GH+ LTDFGLSKE + D ++AYSFCGT+EYMAP++V GH +
Sbjct: 175 YRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDK 234
Query: 248 SADWWSFGVLMFEMLTGTLPF----QGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLF 303
+ DWWS GVLM+E+LTG PF + + E ILK++ PQ +S A+ L++ L
Sbjct: 235 AVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLL 294
Query: 304 KRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTA 363
++P RLG GP +EIK H FF I+W+ L +++ PFKP D F EFT
Sbjct: 295 MKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTE 354
Query: 364 KTPKDSPGIPPSANAHQLFRGFSFVA-----------ITSDDESQAMQTVGVHSIVQQLH 412
P SP P ++ +LF+G+SFVA I ++ GV ++ +
Sbjct: 355 MDPTYSPAALPQ-SSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAM 413
Query: 413 RNSIQFTDGYEV---KEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE-EIEILL 468
F Y++ + +G GS+S+C++C+HK +N FAVKII K T+ EI L
Sbjct: 414 MKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALK 473
Query: 469 RYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVE 528
HPNI+ L +V+ D + ++V EL+ GGEL ++I ++K FSE EAS ++ + V
Sbjct: 474 LCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVS 533
Query: 529 YLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPE 588
++H GVVHRDLKP N+L+ DE+ N E I+I DFGFA+ +N L TPC+T ++ APE
Sbjct: 534 HMHDVGVVHRDLKPENLLFTDENDNLE-IKIIDFGFARLKPPDNQPLKTPCFTLHYAAPE 592
Query: 589 VLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDD----TPEEILARIGSGKFSLSGGY 644
+L + GYD +CD+WSLGV+LYTML+G PF + + EI+ +I G FS G
Sbjct: 593 LLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEA 652
Query: 645 WNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQD----APHLVK 700
W +VS AKDL+ +L VDP++RL + + + W+ QL L D + V
Sbjct: 653 WKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVH 712
Query: 701 GAMAATYSALN--RNQSPVLEPVGRSTLAQRRGIKKITSTA 739
+ AT+ A N + + L+ V ++ LA+RR +KK TST+
Sbjct: 713 TCVKATFHAFNKYKREGFCLQNVDKAPLAKRRKMKK-TSTS 752
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 540 bits (1392), Expect = e-153
Identities = 318/746 (42%), Positives = 442/746 (59%), Gaps = 45/746 (6%)
Query: 33 MGEEEINPQTEEVSIKEIAITHHVKEGHE-KADPSQFELLKVLGQGSFGKVFLVKKISGS 91
MG+E+ +E E+ IT GHE K FELLKVLG G++GKVFLV+K G
Sbjct: 1 MGDED----DDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGH 56
Query: 92 DARQLYAMKVLKKATLKVRDRVR--TKMERDILVEVNH-PFIVKLHYAFQTEGKLYLILD 148
DA +LYAMKVL+KA L R + + T+ ER +L V PF+V LHYAFQT+ KL+LILD
Sbjct: 57 DAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILD 116
Query: 149 FLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIK 208
++ GG++FT L + F E +V+ Y E+ LAL+HLH LGIIYRDLK EN+LLD EGHI
Sbjct: 117 YVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIV 176
Query: 209 LTDFGLSKESIDHEK-KAYSFCGTVEYMAPEVV-NRRGHTQSADWWSFGVLMFEMLTGTL 266
LTDFGLSKE + EK + +SFCGT+EYMAPE++ ++ GH ++ DWWS G+L+FE+LTG
Sbjct: 177 LTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGAS 236
Query: 267 PF----QGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIK 322
PF + + E ILK P + P AQ LL+ L ++P RLGAGP G +E++
Sbjct: 237 PFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVR 296
Query: 323 RHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLF 382
H FF +DW L R+I PF+P D F EFT P SP P ++F
Sbjct: 297 NHPFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIF 356
Query: 383 RGFSFVAIT-SDDESQAMQTVGVH-----------SIVQQLHRNSIQFTDGYEV---KED 427
+G+SFVA + D + A+ T G+ ++ + F YE+ +
Sbjct: 357 QGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPA 416
Query: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQ-HPNIITLKDVYDDG 486
+G GS+SVC+RC + + EFAVKI+ + T+ LR Q HPN++ L +V+ D
Sbjct: 417 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQ 476
Query: 487 KYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQ-GVVHRDLKPSNI 545
+ Y+V EL++GGELL+ I +++ FSE EAS +L ++ V ++H + GVVHRDLKP NI
Sbjct: 477 LHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENI 536
Query: 546 LYVDES-GNPESIRICDFGFAKQLRAENGL-LMTPCYTANFVAPEVLKRQGYDAACDIWS 603
LY D++ G P ++I DFGFA+ G+ + TPC+T + APE+L +QGYD +CD+WS
Sbjct: 537 LYADDTPGAP--VKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWS 594
Query: 604 LGVLLYTMLTGYTPF----ANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKM 659
LGV+LY ML+G PF G EI+ +I G+FSL G W VS+ AK+LV +
Sbjct: 595 LGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGL 654
Query: 660 LHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQD----APHLVKGAMAATYSALNRNQS 715
L VDP +RL + W+ L D + V+ + AT+ A NR +
Sbjct: 655 LTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKR 714
Query: 716 P--VLEPVGRSTLAQRRGIKKITSTA 739
L+ V + LA+RR K ++TA
Sbjct: 715 EGFFLKSVENAPLAKRRKQKLRSATA 740
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 538 bits (1386), Expect = e-153
Identities = 317/740 (42%), Positives = 444/740 (60%), Gaps = 39/740 (5%)
Query: 33 MGEEEINPQTEEVSIKEIAITHHVKEGHE-KADPSQFELLKVLGQGSFGKVFLVKKISGS 91
MG+E+ +E E+ IT GHE K FELLKVLG G++GKVFLV+K G
Sbjct: 1 MGDED----DDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGH 56
Query: 92 DARQLYAMKVLKKATLKVRDRVR--TKMERDILVEVNH-PFIVKLHYAFQTEGKLYLILD 148
DA +LYAMKVL+KA L R + + T+ ER +L V PF+V LHYAFQT+ KL+LILD
Sbjct: 57 DAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILD 116
Query: 149 FLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIK 208
++ GG++FT L + F E +V+ Y E+ LAL+HLH LGIIYRDLK EN+LLD EGHI
Sbjct: 117 YVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIV 176
Query: 209 LTDFGLSKESIDHEK-KAYSFCGTVEYMAPEVV-NRRGHTQSADWWSFGVLMFEMLTGTL 266
LTDFGLSKE + EK + +SFCGT+EYMAPE++ ++ GH ++ DWWS G+L+FE+LTG
Sbjct: 177 LTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGAS 236
Query: 267 PF----QGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIK 322
PF + + E ILK P + P AQ LL+ L ++P RLGAGP G +E++
Sbjct: 237 PFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVR 296
Query: 323 RHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLF 382
H FF +DW L R+I PF+P D F EFT P SP P ++F
Sbjct: 297 NHPFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIF 356
Query: 383 RGFSFVAIT-SDDESQAMQTVGVHSI-------VQQLHRNSIQFTDGYEVKED-IGVGSY 433
+G+SFVA + D + A+ T G+ + + R+++ +++E +G GS+
Sbjct: 357 QGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQQYELDLREPALGQGSF 416
Query: 434 SVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQ-HPNIITLKDVYDDGKYVYVV 492
SVC+RC + + EFAVKI+ + T+ LR Q HPN++ L +V+ D + Y+V
Sbjct: 417 SVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLV 476
Query: 493 TELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQ-GVVHRDLKPSNILYVDES 551
EL++GGELL+ I +++ FSE EAS +L ++ V ++H + GVVHRDLKP NILY D++
Sbjct: 477 LELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDT 536
Query: 552 -GNPESIRICDFGFAKQLRAENGL-LMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLY 609
G P ++I DFGFA+ G+ + TPC+T + APE+L +QGYD +CD+WSLGV+LY
Sbjct: 537 PGAP--VKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILY 594
Query: 610 TMLTGYTPF----ANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPH 665
ML+G PF G EI+ +I G+FSL G W VS+ AK+LV +L VDP
Sbjct: 595 MMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPA 654
Query: 666 QRLTAALVLRHPWIVHWDQLPQYQLNRQD----APHLVKGAMAATYSALNRNQSP--VLE 719
+RL + W+ L D + V+ + AT+ A NR + L+
Sbjct: 655 KRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLK 714
Query: 720 PVGRSTLAQRRGIKKITSTA 739
V + LA+RR K ++TA
Sbjct: 715 SVENAPLAKRRKQKLRSATA 734
>gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b
[Homo sapiens]
Length = 549
Score = 427 bits (1097), Expect = e-119
Identities = 239/554 (43%), Positives = 334/554 (60%), Gaps = 42/554 (7%)
Query: 14 AVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKV 73
A + +D + G+Q++ T + ++ +T H EK FELLKV
Sbjct: 11 AAGTSADGGDGGEQLL------------TVKHELRTANLTGHA----EKVGIENFELLKV 54
Query: 74 LGQGSFGKVFLVKKISGSDARQLYAMKVLKKATL--KVRDRVRTKMERDILVEVNH-PFI 130
LG G++GKVFLV+KISG D +LYAMKVLKKAT+ K + T+ ER +L + PF+
Sbjct: 55 LGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFL 114
Query: 131 VKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGII 190
V LHYAFQTE KL+LILD++ GG+LFT LS+ FTE +V+ Y+ E+ LAL+HLH LGII
Sbjct: 115 VTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGII 174
Query: 191 YRDLKPENILLDEEGHIKLTDFGLSKESI-DHEKKAYSFCGTVEYMAPEVV--NRRGHTQ 247
YRD+K ENILLD GH+ LTDFGLSKE + D ++AYSFCGT+EYMAP++V GH +
Sbjct: 175 YRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDK 234
Query: 248 SADWWSFGVLMFEMLTGTLPF----QGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLF 303
+ DWWS GVLM+E+LTG PF + + E ILK++ PQ +S A+ L++ L
Sbjct: 235 AVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLL 294
Query: 304 KRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTA 363
++P RLG GP +EIK H FF I+W+ L +++ PFKP D F EFT
Sbjct: 295 MKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTE 354
Query: 364 KTPKDSPGIPPSANAHQLFRGFSFVA-----------ITSDDESQAMQTVGVHSIVQQLH 412
P SP P ++ +LF+G+SFVA I ++ GV ++ +
Sbjct: 355 MDPTYSPAALPQ-SSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAM 413
Query: 413 RNSIQFTDGYEV---KEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE-EIEILL 468
F Y++ + +G GS+S+C++C+HK +N FAVKII K T+ EI L
Sbjct: 414 MKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALK 473
Query: 469 RYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVE 528
HPNI+ L +V+ D + ++V EL+ GGEL ++I ++K FSE EAS ++ + V
Sbjct: 474 LCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVS 533
Query: 529 YLHAQGVVHRDLKP 542
++H GVVHRDLKP
Sbjct: 534 HMHDVGVVHRDLKP 547
Score = 115 bits (288), Expect = 1e-25
Identities = 92/335 (27%), Positives = 165/335 (49%), Gaps = 34/335 (10%)
Query: 420 DGYEVKEDIGVGSYS---VCKRCIHKATNMEFAVKIIDKS----KRDPTE----EIEILL 468
+ +E+ + +G G+Y + ++ T +A+K++ K+ K TE E ++L
Sbjct: 47 ENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLE 106
Query: 469 RYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVE 528
Q P ++TL + ++++ + + GGEL + +++ F+E E + I +E
Sbjct: 107 HIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALE 166
Query: 529 YLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRA-ENGLLMTPCYTANFVAP 587
+LH G+++RD+K NIL +D +G+ + + DFG +K+ A E + C T ++AP
Sbjct: 167 HLHKLGIIYRDIKLENIL-LDSNGH---VVLTDFGLSKEFVADETERAYSFCGTIEYMAP 222
Query: 588 EVLK--RQGYDAACDIWSLGVLLYTMLTGYTPF-ANGPDDTPEEILARIGSGKFSLSGGY 644
++++ G+D A D WSLGVL+Y +LTG +PF +G ++ EI RI Y
Sbjct: 223 DIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRI----LKSEPPY 278
Query: 645 WNSVSDTAKDLVSKMLHVDPHQRL-----TAALVLRHPWI--VHWDQLPQYQLNRQDAP- 696
+S AKDL+ ++L DP +RL A + H + ++WD L ++ P
Sbjct: 279 PQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPV 338
Query: 697 ---HLVKGAMAATYSALNRNQSPVLEPVGRSTLAQ 728
L A ++ ++ SP P L Q
Sbjct: 339 IRDELDVSNFAEEFTEMDPTYSPAALPQSSEKLFQ 373
Score = 81.6 bits (200), Expect = 2e-15
Identities = 44/130 (33%), Positives = 75/130 (57%), Gaps = 15/130 (11%)
Query: 72 KVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDI----LVEVNH 127
K LG+GSF + +K + Q +A+K++ K R+ +++I L E H
Sbjct: 430 KPLGEGSFS---ICRKCVHKKSNQAFAVKIISK-------RMEANTQKEITALKLCE-GH 478
Query: 128 PFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSL 187
P IVKLH F + +L+++ L GG+LF R+ K+ F+E + + + +L A+ H+H +
Sbjct: 479 PNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDV 538
Query: 188 GIIYRDLKPE 197
G+++RDLKPE
Sbjct: 539 GVVHRDLKPE 548
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 377 bits (969), Expect = e-104
Identities = 195/376 (51%), Positives = 259/376 (68%), Gaps = 8/376 (2%)
Query: 20 DSAENGQQIMDEPMGEEEINPQT---EEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQ 76
D E G Q+ +E M + P E EI+ T V G EK P FELL+VLG+
Sbjct: 42 DELEEGGQL-NESMDHGGVGPYELGMEHCEKFEISETS-VNRGPEKIRPECFELLRVLGK 99
Query: 77 GSFGKVFLVKKISGSDARQLYAMKVLKKATL--KVRDRVRTKMERDILVEVNHPFIVKLH 134
G +GKVF V+K++G++ +++AMKVLKKA + +D TK ER+IL EV HPFIV L
Sbjct: 100 GGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLI 159
Query: 135 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDL 194
YAFQT GKLYLIL++L GG+LF +L +E +F E+ FYLAE+++AL HLH GIIYRDL
Sbjct: 160 YAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDL 219
Query: 195 KPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSF 254
KPENI+L+ +GH+KLTDFGL KESI ++FCGT+EYMAPE++ R GH ++ DWWS
Sbjct: 220 KPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSL 279
Query: 255 GVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAG 314
G LM++MLTG PF G++RK+T+ ILK KL +P +L+ EA+ LL+ L KRN A+RLGAG
Sbjct: 280 GALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAG 339
Query: 315 PDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPP 374
P E++ H FF I+W +L R++ PPFKP ED FD +FT +TP DSP
Sbjct: 340 PGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDST 399
Query: 375 -SANAHQLFRGFSFVA 389
S +A+Q+F GF++VA
Sbjct: 400 LSESANQVFLGFTYVA 415
Score = 120 bits (302), Expect = 3e-27
Identities = 93/324 (28%), Positives = 161/324 (49%), Gaps = 29/324 (8%)
Query: 422 YEVKEDIGVGSYSVC---KRCIHKATNMEFAVKIIDKSK-----RDP--TEEIEILLRYG 471
+E+ +G G Y ++ T FA+K++ K+ +D T+ +L
Sbjct: 91 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 150
Query: 472 QHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLH 531
+HP I+ L + G +Y++ E + GGEL ++ R+ F E A L I+ + +LH
Sbjct: 151 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH 210
Query: 532 AQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 591
+G+++RDLKP NI+ ++ G+ +++ DFG K+ + + T C T ++APE+L
Sbjct: 211 QKGIIYRDLKPENIM-LNHQGH---VKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 266
Query: 592 RQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDT 651
R G++ A D WSLG L+Y MLTG PF + ++ + +I K +L ++
Sbjct: 267 RSGHNRAVDWWSLGALMYDMLTGAPPFTG---ENRKKTIDKILKCKLNLP----PYLTQE 319
Query: 652 AKDLVSKMLHVDPHQRL-----TAALVLRHPWIVH--WDQLPQYQLNRQDAPHLVKGAMA 704
A+DL+ K+L + RL A V HP+ H W++L ++ P L
Sbjct: 320 ARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDV 379
Query: 705 ATYSALNRNQSPVLEPVGRSTLAQ 728
+ + + Q+PV P STL++
Sbjct: 380 SQFDSKFTRQTPVDSP-DDSTLSE 402
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 365 bits (938), Expect = e-101
Identities = 180/350 (51%), Positives = 243/350 (69%), Gaps = 7/350 (2%)
Query: 43 EEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVL 102
EEV + E + V G E+ P FELL+VLG+G +GKVF V+K+ G++ ++YAMKVL
Sbjct: 46 EEVELTETS----VNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVL 101
Query: 103 KKATL--KVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLS 160
+KA + +D T+ ER+IL V HPFIV+L YAFQT GKLYLIL+ L GG+LFT L
Sbjct: 102 RKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLE 161
Query: 161 KEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESID 220
+E +F E+ FYLAE+ LAL HLHS GIIYRDLKPENI+L +GHIKLTDFGL KESI
Sbjct: 162 REGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIH 221
Query: 221 HEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMI 280
++FCGT+EYMAPE++ R GH ++ DWWS G LM++MLTG+ PF ++RK+TM I
Sbjct: 222 EGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKI 281
Query: 281 LKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREI 340
++ KL +P +L+P+A+ L++ KRNP+ R+G GP +++RH FF ++W+ L +
Sbjct: 282 IRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRV 341
Query: 341 HPPFKPATGRPEDTFYFDPEFTAKTPKDSP-GIPPSANAHQLFRGFSFVA 389
PPF+P ED FD FT +TP DSP S +A+Q F GF++VA
Sbjct: 342 DPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVA 391
Score = 138 bits (347), Expect = 2e-32
Identities = 101/316 (31%), Positives = 160/316 (50%), Gaps = 28/316 (8%)
Query: 422 YEVKEDIGVGSYS-VCKRCIHKATNME--FAVKIIDKSK-----RDP--TEEIEILLRYG 471
+E+ +G G Y V + + TN+ +A+K++ K+K +D T +L
Sbjct: 67 FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV 126
Query: 472 QHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLH 531
+HP I+ L + G +Y++ E + GGEL + R+ F E A L IT + +LH
Sbjct: 127 KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLH 186
Query: 532 AQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 591
+QG+++RDLKP NI+ + I++ DFG K+ E + T C T ++APE+L
Sbjct: 187 SQGIIYRDLKPENIMLSSQG----HIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILV 242
Query: 592 RQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDT 651
R G++ A D WSLG L+Y MLTG PF + ++ + +I GK +L ++
Sbjct: 243 RSGHNRAVDWWSLGALMYDMLTGSPPFT---AENRKKTMDKIIRGKLALP----PYLTPD 295
Query: 652 AKDLVSKMLHVDPHQRL-----TAALVLRHPWIVH--WDQLPQYQLNRQDAPHLVKGAMA 704
A+DLV K L +P QR+ AA V RHP+ H WD L ++++ P L
Sbjct: 296 ARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDV 355
Query: 705 ATYSALNRNQSPVLEP 720
+ + Q+PV P
Sbjct: 356 SQFDTRFTRQTPVDSP 371
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 292 bits (748), Expect = 7e-79
Identities = 158/371 (42%), Positives = 229/371 (61%), Gaps = 33/371 (8%)
Query: 6 LADPWQKMAVE----SPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHE 61
+AD Q+ E SP+ +N +GEEE++ T THH +
Sbjct: 105 VADRLQRQEEERMNCSPTSQIDN--------IGEEEMDAST----------THH-----K 141
Query: 62 KADPSQFELLKVLGQGSFGKVFLVK-KISGSDARQLYAMKVLKKATLKVRDRV-RTKMER 119
+ + F+ LK+LG+G+FGKV LV+ K SG + YAMK+LKK + +D V T E
Sbjct: 142 RKTMNDFDYLKLLGKGTFGKVILVREKASG----KYYAMKILKKEVIIAKDEVAHTLTES 197
Query: 120 DILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 179
+L HPF+ L Y+FQT+ +L +++++ GG+LF LS+E +F+E+ +FY AE+
Sbjct: 198 RVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVS 257
Query: 180 ALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEV 239
ALD+LHS I+YRDLK EN++LD++GHIK+TDFGL KE I +FCGT EY+APEV
Sbjct: 258 ALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEV 317
Query: 240 VNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLL 299
+ + ++ DWW GV+M+EM+ G LPF +D ++ +IL + P+ LS +A+SLL
Sbjct: 318 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLL 377
Query: 300 RMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDP 359
L ++P RLG GPD +EI RHSFFS ++W +Y +++ PPFKP DT YFD
Sbjct: 378 SGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDE 437
Query: 360 EFTAKTPKDSP 370
EFTA+T +P
Sbjct: 438 EFTAQTITITP 448
Score = 110 bits (275), Expect = 5e-24
Identities = 81/271 (29%), Positives = 136/271 (50%), Gaps = 24/271 (8%)
Query: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEI------EILLRYGQHPNIITLKD 481
+G G++ KA+ +A+KI+ K +E+ +L+ +HP + +LK
Sbjct: 154 LGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKY 213
Query: 482 VYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLK 541
+ + V E + GGEL + R++ FSE I ++YLH+ +V+RDLK
Sbjct: 214 SFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLK 273
Query: 542 PSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDI 601
N++ +D+ G+ I+I DFG K+ + + T C T ++APEVL+ Y A D
Sbjct: 274 LENLM-LDKDGH---IKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDW 329
Query: 602 WSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLH 661
W LGV++Y M+ G PF N + E++ + KF ++S AK L+S +L
Sbjct: 330 WGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEDIKFP------RTLSSDAKSLLSGLLI 382
Query: 662 VDPHQRL-----TAALVLRHPWI--VHWDQL 685
DP++RL A ++RH + V+W +
Sbjct: 383 KDPNKRLGGGPDDAKEIMRHSFFSGVNWQDV 413
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 292 bits (748), Expect = 7e-79
Identities = 158/371 (42%), Positives = 229/371 (61%), Gaps = 33/371 (8%)
Query: 6 LADPWQKMAVE----SPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHE 61
+AD Q+ E SP+ +N +GEEE++ T THH +
Sbjct: 105 VADRLQRQEEERMNCSPTSQIDN--------IGEEEMDAST----------THH-----K 141
Query: 62 KADPSQFELLKVLGQGSFGKVFLVK-KISGSDARQLYAMKVLKKATLKVRDRV-RTKMER 119
+ + F+ LK+LG+G+FGKV LV+ K SG + YAMK+LKK + +D V T E
Sbjct: 142 RKTMNDFDYLKLLGKGTFGKVILVREKASG----KYYAMKILKKEVIIAKDEVAHTLTES 197
Query: 120 DILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 179
+L HPF+ L Y+FQT+ +L +++++ GG+LF LS+E +F+E+ +FY AE+
Sbjct: 198 RVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVS 257
Query: 180 ALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEV 239
ALD+LHS I+YRDLK EN++LD++GHIK+TDFGL KE I +FCGT EY+APEV
Sbjct: 258 ALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEV 317
Query: 240 VNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLL 299
+ + ++ DWW GV+M+EM+ G LPF +D ++ +IL + P+ LS +A+SLL
Sbjct: 318 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLL 377
Query: 300 RMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDP 359
L ++P RLG GPD +EI RHSFFS ++W +Y +++ PPFKP DT YFD
Sbjct: 378 SGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDE 437
Query: 360 EFTAKTPKDSP 370
EFTA+T +P
Sbjct: 438 EFTAQTITITP 448
Score = 110 bits (275), Expect = 5e-24
Identities = 81/271 (29%), Positives = 136/271 (50%), Gaps = 24/271 (8%)
Query: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEI------EILLRYGQHPNIITLKD 481
+G G++ KA+ +A+KI+ K +E+ +L+ +HP + +LK
Sbjct: 154 LGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKY 213
Query: 482 VYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLK 541
+ + V E + GGEL + R++ FSE I ++YLH+ +V+RDLK
Sbjct: 214 SFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLK 273
Query: 542 PSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDI 601
N++ +D+ G+ I+I DFG K+ + + T C T ++APEVL+ Y A D
Sbjct: 274 LENLM-LDKDGH---IKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDW 329
Query: 602 WSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLH 661
W LGV++Y M+ G PF N + E++ + KF ++S AK L+S +L
Sbjct: 330 WGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEDIKFP------RTLSSDAKSLLSGLLI 382
Query: 662 VDPHQRL-----TAALVLRHPWI--VHWDQL 685
DP++RL A ++RH + V+W +
Sbjct: 383 KDPNKRLGGGPDDAKEIMRHSFFSGVNWQDV 413
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 290 bits (743), Expect = 3e-78
Identities = 149/350 (42%), Positives = 216/350 (61%), Gaps = 17/350 (4%)
Query: 25 GQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFL 84
G+ MD G + TEE+ + V + K + F+ LK+LG+G+FGKV L
Sbjct: 116 GEDPMDYKCGSPSDSSTTEEMEVA-------VSKARAKVTMNDFDYLKLLGKGTFGKVIL 168
Query: 85 VK-KISGSDARQLYAMKVLKKATLKVRDRV-RTKMERDILVEVNHPFIVKLHYAFQTEGK 142
V+ K +G + YAMK+L+K + +D V T E +L HPF+ L YAFQT +
Sbjct: 169 VREKATG----RYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDR 224
Query: 143 LYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD 202
L ++++ GG+LF LS+E +FTEE +FY AE+ AL++LHS ++YRD+K EN++LD
Sbjct: 225 LCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLD 284
Query: 203 EEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEML 262
++GHIK+TDFGL KE I +FCGT EY+APEV+ + ++ DWW GV+M+EM+
Sbjct: 285 KDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 344
Query: 263 TGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIK 322
G LPF +D + +IL ++ P+ LSPEA+SLL L K++P RLG GP +E+
Sbjct: 345 CGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVM 404
Query: 323 RHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAK----TPKD 368
H FF +I+W + ++++ PPFKP DT YFD EFTA+ TP D
Sbjct: 405 EHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPD 454
Score = 114 bits (285), Expect = 3e-25
Identities = 83/276 (30%), Positives = 138/276 (50%), Gaps = 24/276 (8%)
Query: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEI------EILLRYGQHPNIITLKD 481
+G G++ KAT +A+KI+ K +E+ +L+ +HP + LK
Sbjct: 158 LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKY 217
Query: 482 VYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLK 541
+ + V E GGEL + R++ F+E A I +EYLH++ VV+RD+K
Sbjct: 218 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIK 277
Query: 542 PSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDI 601
N++ +D+ G+ I+I DFG K+ ++ + T C T ++APEVL+ Y A D
Sbjct: 278 LENLM-LDKDGH---IKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDW 333
Query: 602 WSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLH 661
W LGV++Y M+ G PF N + E++ + +F ++S AK L++ +L
Sbjct: 334 WGLGVVMYEMMCGRLPFYNQDHERLFELIL-MEEIRFP------RTLSPEAKSLLAGLLK 386
Query: 662 VDPHQRL-----TAALVLRHPWI--VHWDQLPQYQL 690
DP QRL A V+ H + ++W + Q +L
Sbjct: 387 KDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKL 422
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 284 bits (727), Expect = 2e-76
Identities = 153/339 (45%), Positives = 210/339 (61%), Gaps = 14/339 (4%)
Query: 63 ADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVL-KKATLKVRDRVRTKMERDI 121
A PS F LKV+G+GSFGKV L + + YA+KVL KKA LK ++ ER++
Sbjct: 93 AKPSDFHFLKVIGKGSFGKVLLARHKA---EEVFYAVKVLQKKAILKKKEEKHIMSERNV 149
Query: 122 LVE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180
L++ V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 150 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 209
Query: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 240
L +LHSL I+YRDLKPENILLD +GHI LTDFGL KE+I+H +FCGT EY+APEV+
Sbjct: 210 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 269
Query: 241 NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLR 300
+++ + ++ DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 270 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 329
Query: 301 MLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPE 360
L +++ RLGA D EIK H FFS I+W+ L ++I PPF P P D +FDPE
Sbjct: 330 GLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 388
Query: 361 FTAKTPKDSPGIPPSA--------NAHQLFRGFSFVAIT 391
FT + +S G P + A + F GFS+ T
Sbjct: 389 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 427
Score = 118 bits (296), Expect = 2e-26
Identities = 91/310 (29%), Positives = 146/310 (47%), Gaps = 25/310 (8%)
Query: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKS-------KRDPTEEIEILLRYGQHPNIITLK 480
IG GS+ HKA + +AVK++ K ++ E +LL+ +HP ++ L
Sbjct: 104 IGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLH 163
Query: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540
+ +Y V + + GGEL + R++ F E A I + YLH+ +V+RDL
Sbjct: 164 FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDL 223
Query: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD 600
KP NIL +D G+ I + DFG K+ N T C T ++APEVL +Q YD D
Sbjct: 224 KPENIL-LDSQGH---IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVD 279
Query: 601 IWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKML 660
W LG +LY ML G PF + E+ I + L +++++A+ L+ +L
Sbjct: 280 WWCLGAVLYEMLYGLPPFYS---RNTAEMYDNILNKPLQLK----PNITNSARHLLEGLL 332
Query: 661 HVDPHQRLTA----ALVLRHPW--IVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQ 714
D +RL A + H + +++WD L ++ P+ V G + +
Sbjct: 333 QKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPN-VSGPNDLRHFDPEFTE 391
Query: 715 SPVLEPVGRS 724
PV +G+S
Sbjct: 392 EPVPNSIGKS 401
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 284 bits (727), Expect = 2e-76
Identities = 153/339 (45%), Positives = 210/339 (61%), Gaps = 14/339 (4%)
Query: 63 ADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVL-KKATLKVRDRVRTKMERDI 121
A PS F LKV+G+GSFGKV L + + YA+KVL KKA LK ++ ER++
Sbjct: 107 AKPSDFHFLKVIGKGSFGKVLLARHKA---EEVFYAVKVLQKKAILKKKEEKHIMSERNV 163
Query: 122 LVE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180
L++ V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 164 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 223
Query: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 240
L +LHSL I+YRDLKPENILLD +GHI LTDFGL KE+I+H +FCGT EY+APEV+
Sbjct: 224 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 283
Query: 241 NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLR 300
+++ + ++ DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 284 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 343
Query: 301 MLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPE 360
L +++ RLGA D EIK H FFS I+W+ L ++I PPF P P D +FDPE
Sbjct: 344 GLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 402
Query: 361 FTAKTPKDSPGIPPSA--------NAHQLFRGFSFVAIT 391
FT + +S G P + A + F GFS+ T
Sbjct: 403 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 441
Score = 118 bits (296), Expect = 2e-26
Identities = 91/310 (29%), Positives = 146/310 (47%), Gaps = 25/310 (8%)
Query: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKS-------KRDPTEEIEILLRYGQHPNIITLK 480
IG GS+ HKA + +AVK++ K ++ E +LL+ +HP ++ L
Sbjct: 118 IGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLH 177
Query: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540
+ +Y V + + GGEL + R++ F E A I + YLH+ +V+RDL
Sbjct: 178 FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDL 237
Query: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD 600
KP NIL +D G+ I + DFG K+ N T C T ++APEVL +Q YD D
Sbjct: 238 KPENIL-LDSQGH---IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVD 293
Query: 601 IWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKML 660
W LG +LY ML G PF + E+ I + L +++++A+ L+ +L
Sbjct: 294 WWCLGAVLYEMLYGLPPFYS---RNTAEMYDNILNKPLQLK----PNITNSARHLLEGLL 346
Query: 661 HVDPHQRLTA----ALVLRHPW--IVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQ 714
D +RL A + H + +++WD L ++ P+ V G + +
Sbjct: 347 QKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPN-VSGPNDLRHFDPEFTE 405
Query: 715 SPVLEPVGRS 724
PV +G+S
Sbjct: 406 EPVPNSIGKS 415
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 284 bits (727), Expect = 2e-76
Identities = 153/339 (45%), Positives = 210/339 (61%), Gaps = 14/339 (4%)
Query: 63 ADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVL-KKATLKVRDRVRTKMERDI 121
A PS F LKV+G+GSFGKV L + + YA+KVL KKA LK ++ ER++
Sbjct: 121 AKPSDFHFLKVIGKGSFGKVLLARHKA---EEVFYAVKVLQKKAILKKKEEKHIMSERNV 177
Query: 122 LVE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180
L++ V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 178 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 237
Query: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 240
L +LHSL I+YRDLKPENILLD +GHI LTDFGL KE+I+H +FCGT EY+APEV+
Sbjct: 238 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 297
Query: 241 NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLR 300
+++ + ++ DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 298 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 357
Query: 301 MLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPE 360
L +++ RLGA D EIK H FFS I+W+ L ++I PPF P P D +FDPE
Sbjct: 358 GLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 416
Query: 361 FTAKTPKDSPGIPPSA--------NAHQLFRGFSFVAIT 391
FT + +S G P + A + F GFS+ T
Sbjct: 417 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 455
Score = 118 bits (296), Expect = 2e-26
Identities = 91/310 (29%), Positives = 146/310 (47%), Gaps = 25/310 (8%)
Query: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKS-------KRDPTEEIEILLRYGQHPNIITLK 480
IG GS+ HKA + +AVK++ K ++ E +LL+ +HP ++ L
Sbjct: 132 IGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLH 191
Query: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540
+ +Y V + + GGEL + R++ F E A I + YLH+ +V+RDL
Sbjct: 192 FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDL 251
Query: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD 600
KP NIL +D G+ I + DFG K+ N T C T ++APEVL +Q YD D
Sbjct: 252 KPENIL-LDSQGH---IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVD 307
Query: 601 IWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKML 660
W LG +LY ML G PF + E+ I + L +++++A+ L+ +L
Sbjct: 308 WWCLGAVLYEMLYGLPPFYS---RNTAEMYDNILNKPLQLK----PNITNSARHLLEGLL 360
Query: 661 HVDPHQRLTA----ALVLRHPW--IVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQ 714
D +RL A + H + +++WD L ++ P+ V G + +
Sbjct: 361 QKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPN-VSGPNDLRHFDPEFTE 419
Query: 715 SPVLEPVGRS 724
PV +G+S
Sbjct: 420 EPVPNSIGKS 429
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 284 bits (727), Expect = 2e-76
Identities = 153/339 (45%), Positives = 210/339 (61%), Gaps = 14/339 (4%)
Query: 63 ADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVL-KKATLKVRDRVRTKMERDI 121
A PS F LKV+G+GSFGKV L + + YA+KVL KKA LK ++ ER++
Sbjct: 188 AKPSDFHFLKVIGKGSFGKVLLARHKA---EEVFYAVKVLQKKAILKKKEEKHIMSERNV 244
Query: 122 LVE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180
L++ V HPF+V LH++FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 245 LLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASA 304
Query: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 240
L +LHSL I+YRDLKPENILLD +GHI LTDFGL KE+I+H +FCGT EY+APEV+
Sbjct: 305 LGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL 364
Query: 241 NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLR 300
+++ + ++ DWW G +++EML G PF ++ E IL L + ++ A+ LL
Sbjct: 365 HKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLE 424
Query: 301 MLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPE 360
L +++ RLGA D EIK H FFS I+W+ L ++I PPF P P D +FDPE
Sbjct: 425 GLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE 483
Query: 361 FTAKTPKDSPGIPPSA--------NAHQLFRGFSFVAIT 391
FT + +S G P + A + F GFS+ T
Sbjct: 484 FTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 522
Score = 118 bits (296), Expect = 2e-26
Identities = 91/310 (29%), Positives = 146/310 (47%), Gaps = 25/310 (8%)
Query: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKS-------KRDPTEEIEILLRYGQHPNIITLK 480
IG GS+ HKA + +AVK++ K ++ E +LL+ +HP ++ L
Sbjct: 199 IGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLH 258
Query: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540
+ +Y V + + GGEL + R++ F E A I + YLH+ +V+RDL
Sbjct: 259 FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDL 318
Query: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD 600
KP NIL +D G+ I + DFG K+ N T C T ++APEVL +Q YD D
Sbjct: 319 KPENIL-LDSQGH---IVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVD 374
Query: 601 IWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKML 660
W LG +LY ML G PF + E+ I + L +++++A+ L+ +L
Sbjct: 375 WWCLGAVLYEMLYGLPPFYS---RNTAEMYDNILNKPLQLK----PNITNSARHLLEGLL 427
Query: 661 HVDPHQRLTA----ALVLRHPW--IVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQ 714
D +RL A + H + +++WD L ++ P+ V G + +
Sbjct: 428 QKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPN-VSGPNDLRHFDPEFTE 486
Query: 715 SPVLEPVGRS 724
PV +G+S
Sbjct: 487 EPVPNSIGKS 496
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 284 bits (726), Expect = 2e-76
Identities = 152/363 (41%), Positives = 222/363 (61%), Gaps = 19/363 (5%)
Query: 14 AVESPSDSAENGQQI-MDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLK 72
A+++ +D + ++ MD G N EE+ + H V ++FE LK
Sbjct: 102 AIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTM-------NEFEYLK 154
Query: 73 VLGQGSFGKVFLVK-KISGSDARQLYAMKVLKKATLKVRDRV-RTKMERDILVEVNHPFI 130
+LG+G+FGKV LVK K +G + YAMK+LKK + +D V T E +L HPF+
Sbjct: 155 LLGKGTFGKVILVKEKATG----RYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFL 210
Query: 131 VKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHS-LGI 189
L Y+FQT +L ++++ GG+LF LS+E +F+E+ +FY AE+ ALD+LHS +
Sbjct: 211 TALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNV 270
Query: 190 IYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSA 249
+YRDLK EN++LD++GHIK+TDFGL KE I +FCGT EY+APEV+ + ++
Sbjct: 271 VYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAV 330
Query: 250 DWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPAN 309
DWW GV+M+EM+ G LPF +D ++ +IL ++ P+ L PEA+SLL L K++P
Sbjct: 331 DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQ 390
Query: 310 RLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAK----T 365
RLG G + +EI +H FF+ I W +Y +++ PPFKP DT YFD EFTA+ T
Sbjct: 391 RLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITIT 450
Query: 366 PKD 368
P D
Sbjct: 451 PPD 453
Score = 108 bits (271), Expect = 1e-23
Identities = 82/270 (30%), Positives = 135/270 (50%), Gaps = 21/270 (7%)
Query: 406 SIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEI- 464
S+ + HR ++ + +E + +G G++ KAT +A+KI+ K +E+
Sbjct: 137 SLAKPKHRVTM---NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVA 193
Query: 465 -----EILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAV 519
+L+ +HP + LK + + V E GGEL + R++ FSE A
Sbjct: 194 HTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFY 253
Query: 520 LFTITKTVEYLHAQ-GVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTP 578
I ++YLH++ VV+RDLK N++ +D+ G+ I+I DFG K+ + + T
Sbjct: 254 GAEIVSALDYLHSEKNVVYRDLKLENLM-LDKDGH---IKITDFGLCKEGIKDGATMKTF 309
Query: 579 CYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKF 638
C T ++APEVL+ Y A D W LGV++Y M+ G PF N + E++ + +F
Sbjct: 310 CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEEIRF 368
Query: 639 SLSGGYWNSVSDTAKDLVSKMLHVDPHQRL 668
++ AK L+S +L DP QRL
Sbjct: 369 P------RTLGPEAKSLLSGLLKKDPKQRL 392
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 284 bits (726), Expect = 2e-76
Identities = 152/363 (41%), Positives = 222/363 (61%), Gaps = 19/363 (5%)
Query: 14 AVESPSDSAENGQQI-MDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLK 72
A+++ +D + ++ MD G N EE+ + H V ++FE LK
Sbjct: 102 AIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTM-------NEFEYLK 154
Query: 73 VLGQGSFGKVFLVK-KISGSDARQLYAMKVLKKATLKVRDRV-RTKMERDILVEVNHPFI 130
+LG+G+FGKV LVK K +G + YAMK+LKK + +D V T E +L HPF+
Sbjct: 155 LLGKGTFGKVILVKEKATG----RYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFL 210
Query: 131 VKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHS-LGI 189
L Y+FQT +L ++++ GG+LF LS+E +F+E+ +FY AE+ ALD+LHS +
Sbjct: 211 TALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNV 270
Query: 190 IYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSA 249
+YRDLK EN++LD++GHIK+TDFGL KE I +FCGT EY+APEV+ + ++
Sbjct: 271 VYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAV 330
Query: 250 DWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPAN 309
DWW GV+M+EM+ G LPF +D ++ +IL ++ P+ L PEA+SLL L K++P
Sbjct: 331 DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQ 390
Query: 310 RLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAK----T 365
RLG G + +EI +H FF+ I W +Y +++ PPFKP DT YFD EFTA+ T
Sbjct: 391 RLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITIT 450
Query: 366 PKD 368
P D
Sbjct: 451 PPD 453
Score = 108 bits (271), Expect = 1e-23
Identities = 82/270 (30%), Positives = 135/270 (50%), Gaps = 21/270 (7%)
Query: 406 SIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEI- 464
S+ + HR ++ + +E + +G G++ KAT +A+KI+ K +E+
Sbjct: 137 SLAKPKHRVTM---NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVA 193
Query: 465 -----EILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAV 519
+L+ +HP + LK + + V E GGEL + R++ FSE A
Sbjct: 194 HTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFY 253
Query: 520 LFTITKTVEYLHAQ-GVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTP 578
I ++YLH++ VV+RDLK N++ +D+ G+ I+I DFG K+ + + T
Sbjct: 254 GAEIVSALDYLHSEKNVVYRDLKLENLM-LDKDGH---IKITDFGLCKEGIKDGATMKTF 309
Query: 579 CYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKF 638
C T ++APEVL+ Y A D W LGV++Y M+ G PF N + E++ + +F
Sbjct: 310 CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEEIRF 368
Query: 639 SLSGGYWNSVSDTAKDLVSKMLHVDPHQRL 668
++ AK L+S +L DP QRL
Sbjct: 369 P------RTLGPEAKSLLSGLLKKDPKQRL 392
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 284 bits (726), Expect = 2e-76
Identities = 152/363 (41%), Positives = 222/363 (61%), Gaps = 19/363 (5%)
Query: 14 AVESPSDSAENGQQI-MDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLK 72
A+++ +D + ++ MD G N EE+ + H V ++FE LK
Sbjct: 102 AIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTM-------NEFEYLK 154
Query: 73 VLGQGSFGKVFLVK-KISGSDARQLYAMKVLKKATLKVRDRV-RTKMERDILVEVNHPFI 130
+LG+G+FGKV LVK K +G + YAMK+LKK + +D V T E +L HPF+
Sbjct: 155 LLGKGTFGKVILVKEKATG----RYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFL 210
Query: 131 VKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHS-LGI 189
L Y+FQT +L ++++ GG+LF LS+E +F+E+ +FY AE+ ALD+LHS +
Sbjct: 211 TALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNV 270
Query: 190 IYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSA 249
+YRDLK EN++LD++GHIK+TDFGL KE I +FCGT EY+APEV+ + ++
Sbjct: 271 VYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAV 330
Query: 250 DWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPAN 309
DWW GV+M+EM+ G LPF +D ++ +IL ++ P+ L PEA+SLL L K++P
Sbjct: 331 DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQ 390
Query: 310 RLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAK----T 365
RLG G + +EI +H FF+ I W +Y +++ PPFKP DT YFD EFTA+ T
Sbjct: 391 RLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITIT 450
Query: 366 PKD 368
P D
Sbjct: 451 PPD 453
Score = 108 bits (271), Expect = 1e-23
Identities = 82/270 (30%), Positives = 135/270 (50%), Gaps = 21/270 (7%)
Query: 406 SIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEI- 464
S+ + HR ++ + +E + +G G++ KAT +A+KI+ K +E+
Sbjct: 137 SLAKPKHRVTM---NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVA 193
Query: 465 -----EILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAV 519
+L+ +HP + LK + + V E GGEL + R++ FSE A
Sbjct: 194 HTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFY 253
Query: 520 LFTITKTVEYLHAQ-GVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTP 578
I ++YLH++ VV+RDLK N++ +D+ G+ I+I DFG K+ + + T
Sbjct: 254 GAEIVSALDYLHSEKNVVYRDLKLENLM-LDKDGH---IKITDFGLCKEGIKDGATMKTF 309
Query: 579 CYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKF 638
C T ++APEVL+ Y A D W LGV++Y M+ G PF N + E++ + +F
Sbjct: 310 CGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL-MEEIRF 368
Query: 639 SLSGGYWNSVSDTAKDLVSKMLHVDPHQRL 668
++ AK L+S +L DP QRL
Sbjct: 369 P------RTLGPEAKSLLSGLLKKDPKQRL 392
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 278 bits (711), Expect = 1e-74
Identities = 150/338 (44%), Positives = 207/338 (61%), Gaps = 11/338 (3%)
Query: 63 ADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVL-KKATLKVRDRVRTKMERDI 121
A P+ F+ LKV+G+G++GKV L K+ S YA+KVL KK+ LK +++ ER +
Sbjct: 30 AQPTDFDFLKVIGKGNYGKVLLAKRKSDG---AFYAVKVLQKKSILKKKEQSHIMAERSV 86
Query: 122 LVE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180
L++ V HPF+V L Y+FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 87 LLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASA 146
Query: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 240
+ +LHSL IIYRDLKPENILLD +GH+ LTDFGL KE ++ E +FCGT EY+APEV+
Sbjct: 147 IGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVL 206
Query: 241 NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLR 300
+ + ++ DWW G +++EML G PF +D + IL L +P + A LL+
Sbjct: 207 RKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQ 266
Query: 301 MLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPE 360
L ++ RLG+ D + EIK H FFS I+W+ LY + + PPF P P D +FDPE
Sbjct: 267 SLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPE 325
Query: 361 FTAKTPKDSPGIPP-----SANAHQLFRGFSFVAITSD 393
FT + S G P S+ A F GFS+ D
Sbjct: 326 FTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPEDDD 363
Score = 114 bits (286), Expect = 2e-25
Identities = 83/284 (29%), Positives = 137/284 (48%), Gaps = 24/284 (8%)
Query: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKS----KRDPTE---EIEILLRYGQHPNIITLK 480
IG G+Y K+ +AVK++ K K++ + E +LL+ +HP ++ L+
Sbjct: 41 IGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLR 100
Query: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540
+ + +Y V + + GGEL + R++ F E A + + YLH+ +++RDL
Sbjct: 101 YSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDL 160
Query: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD 600
KP NIL +D G+ + + DFG K+ T C T ++APEVL+++ YD A D
Sbjct: 161 KPENIL-LDCQGH---VVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVD 216
Query: 601 IWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKML 660
W LG +LY ML G PF + ++ I + GG + A DL+ +L
Sbjct: 217 WWCLGAVLYEMLHGLPPFYS---QDVSQMYENILHQPLQIPGGR----TVAACDLLQSLL 269
Query: 661 HVDPHQRLTAAL----VLRHPWI--VHWDQLPQYQLNRQDAPHL 698
H D QRL + + H + ++WD L +L P++
Sbjct: 270 HKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNV 313
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 278 bits (711), Expect = 1e-74
Identities = 150/338 (44%), Positives = 207/338 (61%), Gaps = 11/338 (3%)
Query: 63 ADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVL-KKATLKVRDRVRTKMERDI 121
A P+ F+ LKV+G+G++GKV L K+ S YA+KVL KK+ LK +++ ER +
Sbjct: 90 AQPTDFDFLKVIGKGNYGKVLLAKRKSDG---AFYAVKVLQKKSILKKKEQSHIMAERSV 146
Query: 122 LVE-VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180
L++ V HPF+V L Y+FQT KLY +LD++ GG+LF L +E F E +FY AE+A A
Sbjct: 147 LLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASA 206
Query: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV 240
+ +LHSL IIYRDLKPENILLD +GH+ LTDFGL KE ++ E +FCGT EY+APEV+
Sbjct: 207 IGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVL 266
Query: 241 NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLR 300
+ + ++ DWW G +++EML G PF +D + IL L +P + A LL+
Sbjct: 267 RKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQ 326
Query: 301 MLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPE 360
L ++ RLG+ D + EIK H FFS I+W+ LY + + PPF P P D +FDPE
Sbjct: 327 SLLHKDQRQRLGSKADFL-EIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPE 385
Query: 361 FTAKTPKDSPGIPP-----SANAHQLFRGFSFVAITSD 393
FT + S G P S+ A F GFS+ D
Sbjct: 386 FTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPEDDD 423
Score = 114 bits (286), Expect = 2e-25
Identities = 83/284 (29%), Positives = 137/284 (48%), Gaps = 24/284 (8%)
Query: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKS----KRDPTE---EIEILLRYGQHPNIITLK 480
IG G+Y K+ +AVK++ K K++ + E +LL+ +HP ++ L+
Sbjct: 101 IGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLR 160
Query: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540
+ + +Y V + + GGEL + R++ F E A + + YLH+ +++RDL
Sbjct: 161 YSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDL 220
Query: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD 600
KP NIL +D G+ + + DFG K+ T C T ++APEVL+++ YD A D
Sbjct: 221 KPENIL-LDCQGH---VVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVD 276
Query: 601 IWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKML 660
W LG +LY ML G PF + ++ I + GG + A DL+ +L
Sbjct: 277 WWCLGAVLYEMLHGLPPFYS---QDVSQMYENILHQPLQIPGGR----TVAACDLLQSLL 329
Query: 661 HVDPHQRLTAAL----VLRHPWI--VHWDQLPQYQLNRQDAPHL 698
H D QRL + + H + ++WD L +L P++
Sbjct: 330 HKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNV 373
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 270 bits (689), Expect = 5e-72
Identities = 156/380 (41%), Positives = 219/380 (57%), Gaps = 20/380 (5%)
Query: 29 MDEPMGEEEINPQTEEVSIKEIAITHHV----KEGHEKADPSQFELLKVLGQGSFGKVFL 84
MD P + + + +E S +++ T G+ A P+ F+ LKV+G+GSFGKV L
Sbjct: 119 MDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLL 178
Query: 85 VK-KISGSDARQLYAMKVL-KKATLKVRDRVRTKMERDILVE-VNHPFIVKLHYAFQTEG 141
K K+ G + YA+KVL KK L +++ ER++L++ V HPF+V LHY+FQT
Sbjct: 179 AKRKLDG----KFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTE 234
Query: 142 KLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILL 201
KLY +LDF+ GG+LF L +E F E +FY AE+A AL +LHS+ I+YRDLKPENILL
Sbjct: 235 KLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILL 294
Query: 202 DEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEM 261
D GH+ LTDFGL KE I +FCGT EY+APEV+ ++ + + DWW G +++EM
Sbjct: 295 DSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEM 354
Query: 262 LTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEI 321
L G PF +D E IL L + +S A S+L L +++ NRLGA D + EI
Sbjct: 355 LYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFL-EI 413
Query: 322 KRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPS------ 375
+ H FF ++ W L +++I PPF P P+D FD FT +T S +
Sbjct: 414 QNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNA 473
Query: 376 --ANAHQLFRGFSFVAITSD 393
A F GFS+ + D
Sbjct: 474 SVLEADDAFVGFSYAPPSED 493
Score = 108 bits (270), Expect = 2e-23
Identities = 85/277 (30%), Positives = 132/277 (47%), Gaps = 26/277 (9%)
Query: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKS-------KRDPTEEIEILLRYGQHPNIITLK 480
IG GS+ K +AVK++ K ++ E +LL+ +HP ++ L
Sbjct: 168 IGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLH 227
Query: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540
+ + +Y V + + GGEL + R++ F E A I + YLH+ +V+RDL
Sbjct: 228 YSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDL 287
Query: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD 600
KP NIL +D G+ + + DFG K+ A + T C T ++APEV+++Q YD D
Sbjct: 288 KPENIL-LDSVGH---VVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVD 343
Query: 601 IWSLGVLLYTMLTGYTPF-ANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKM 659
W LG +LY ML G PF + + IL + SL G VS TA ++ ++
Sbjct: 344 WWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHK----PLSLRPG----VSLTAWSILEEL 395
Query: 660 LHVDPHQRLTA----ALVLRHPWI--VHWDQLPQYQL 690
L D RL A + HP+ + W L Q ++
Sbjct: 396 LEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKI 432
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 270 bits (689), Expect = 5e-72
Identities = 156/380 (41%), Positives = 219/380 (57%), Gaps = 20/380 (5%)
Query: 29 MDEPMGEEEINPQTEEVSIKEIAITHHV----KEGHEKADPSQFELLKVLGQGSFGKVFL 84
MD P + + + +E S +++ T G+ A P+ F+ LKV+G+GSFGKV L
Sbjct: 119 MDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLL 178
Query: 85 VK-KISGSDARQLYAMKVL-KKATLKVRDRVRTKMERDILVE-VNHPFIVKLHYAFQTEG 141
K K+ G + YA+KVL KK L +++ ER++L++ V HPF+V LHY+FQT
Sbjct: 179 AKRKLDG----KFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTE 234
Query: 142 KLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILL 201
KLY +LDF+ GG+LF L +E F E +FY AE+A AL +LHS+ I+YRDLKPENILL
Sbjct: 235 KLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILL 294
Query: 202 DEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEM 261
D GH+ LTDFGL KE I +FCGT EY+APEV+ ++ + + DWW G +++EM
Sbjct: 295 DSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEM 354
Query: 262 LTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEI 321
L G PF +D E IL L + +S A S+L L +++ NRLGA D + EI
Sbjct: 355 LYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFL-EI 413
Query: 322 KRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPS------ 375
+ H FF ++ W L +++I PPF P P+D FD FT +T S +
Sbjct: 414 QNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNA 473
Query: 376 --ANAHQLFRGFSFVAITSD 393
A F GFS+ + D
Sbjct: 474 SVLEADDAFVGFSYAPPSED 493
Score = 108 bits (270), Expect = 2e-23
Identities = 85/277 (30%), Positives = 132/277 (47%), Gaps = 26/277 (9%)
Query: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKS-------KRDPTEEIEILLRYGQHPNIITLK 480
IG GS+ K +AVK++ K ++ E +LL+ +HP ++ L
Sbjct: 168 IGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLH 227
Query: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540
+ + +Y V + + GGEL + R++ F E A I + YLH+ +V+RDL
Sbjct: 228 YSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDL 287
Query: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD 600
KP NIL +D G+ + + DFG K+ A + T C T ++APEV+++Q YD D
Sbjct: 288 KPENIL-LDSVGH---VVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVD 343
Query: 601 IWSLGVLLYTMLTGYTPF-ANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKM 659
W LG +LY ML G PF + + IL + SL G VS TA ++ ++
Sbjct: 344 WWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHK----PLSLRPG----VSLTAWSILEEL 395
Query: 660 LHVDPHQRLTA----ALVLRHPWI--VHWDQLPQYQL 690
L D RL A + HP+ + W L Q ++
Sbjct: 396 LEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKI 432
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 264 bits (674), Expect = 3e-70
Identities = 142/329 (43%), Positives = 202/329 (61%), Gaps = 13/329 (3%)
Query: 66 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKM--ERDILV 123
+ F L VLG+GSFGKV L ++ G+D +LYA+K+LKK + D V M +R + +
Sbjct: 340 TDFNFLMVLGKGSFGKVMLSER-KGTD--ELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396
Query: 124 EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDH 183
PF+ +LH FQT +LY +++++ GGDL + + F E FY AE+A+ L
Sbjct: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456
Query: 184 LHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRR 243
L S GIIYRDLK +N++LD EGHIK+ DFG+ KE+I +FCGT +Y+APE++ +
Sbjct: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516
Query: 244 GHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLF 303
+ +S DWW+FGVL++EML G PF+G+D E I++ + P+ +S EA ++ + L
Sbjct: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLM 576
Query: 304 KRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTA 363
++P RLG GP+G +IK H+FF IDW KL R+EI PP+KP DT FD EFT
Sbjct: 577 TKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTR 636
Query: 364 K----TPKDSPGIPPSANAHQ-LFRGFSF 387
+ TP D I N Q F GFS+
Sbjct: 637 QPVELTPTDKLFI---MNLDQNEFAGFSY 662
Score = 96.3 bits (238), Expect = 9e-20
Identities = 65/220 (29%), Positives = 109/220 (49%), Gaps = 12/220 (5%)
Query: 412 HRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIE------ 465
+R+ ++ TD + +G GS+ K T+ +AVKI+ K +++E
Sbjct: 333 NRDRMKLTD-FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 391
Query: 466 -ILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTIT 524
+L G+ P + L + +Y V E + GG+L+ I + F E A I
Sbjct: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451
Query: 525 KTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANF 584
+ +L ++G+++RDLK N++ +D G+ I+I DFG K+ + T C T ++
Sbjct: 452 IGLFFLQSKGIIYRDLKLDNVM-LDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDY 507
Query: 585 VAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDD 624
+APE++ Q Y + D W+ GVLLY ML G PF +D
Sbjct: 508 IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDED 547
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 260 bits (665), Expect = 3e-69
Identities = 140/328 (42%), Positives = 201/328 (61%), Gaps = 10/328 (3%)
Query: 66 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKM--ERDILV 123
+ F L VLG+GSFGKV L ++ G+D +LYA+K+LKK + D V M +R + +
Sbjct: 340 TDFNFLMVLGKGSFGKVMLSER-KGTD--ELYAVKILKKDVVIQDDDVECTMVEKRVLAL 396
Query: 124 EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDH 183
PF+ +LH FQT +LY +++++ GGDL + + F E FY AE+A+ L
Sbjct: 397 PGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 456
Query: 184 LHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRR 243
L S GIIYRDLK +N++LD EGHIK+ DFG+ KE+I +FCGT +Y+APE++ +
Sbjct: 457 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQ 516
Query: 244 GHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLF 303
+ +S DWW+FGVL++EML G PF+G+D E I++ + P+ +S EA ++ + L
Sbjct: 517 PYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLM 576
Query: 304 KRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKP-ATGRPEDTF--YFDPE 360
++P RLG GP+G +IK H+FF IDW KL R+EI PP+KP A GR + F +F
Sbjct: 577 TKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGRNAENFDRFFTRH 636
Query: 361 FTAKTPKDSPGIPPSANAHQLFRGFSFV 388
TP D I + F GFSFV
Sbjct: 637 PPVLTPPDQEVIRNIDQSE--FEGFSFV 662
Score = 97.8 bits (242), Expect = 3e-20
Identities = 85/323 (26%), Positives = 146/323 (45%), Gaps = 27/323 (8%)
Query: 412 HRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIE------ 465
+R+ ++ TD + +G GS+ K T+ +AVKI+ K +++E
Sbjct: 333 NRDRMKLTD-FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEK 391
Query: 466 -ILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTIT 524
+L G+ P + L + +Y V E + GG+L+ I + F E A I
Sbjct: 392 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIA 451
Query: 525 KTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANF 584
+ +L ++G+++RDLK N++ +D G+ I+I DFG K+ + T C T ++
Sbjct: 452 IGLFFLQSKGIIYRDLKLDNVM-LDSEGH---IKIADFGMCKENIWDGVTTKTFCGTPDY 507
Query: 585 VAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGY 644
+APE++ Q Y + D W+ GVLLY ML G PF G D+ +E+ I + Y
Sbjct: 508 IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPF-EGEDE--DELFQSI----MEHNVAY 560
Query: 645 WNSVSDTAKDLVSKMLHVDPHQRLTAAL-----VLRHPWI--VHWDQLPQYQLNRQDAPH 697
S+S A + ++ P +RL + H + + W++L + ++ P
Sbjct: 561 PKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPK 620
Query: 698 LVKGAMAATYSALNRNQSPVLEP 720
G A + PVL P
Sbjct: 621 AC-GRNAENFDRFFTRHPPVLTP 642
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 257 bits (656), Expect = 3e-68
Identities = 146/404 (36%), Positives = 220/404 (54%), Gaps = 23/404 (5%)
Query: 3 LAQLADPWQKMAVESPSDSAENGQQIMDE-----PMGEEEINPQTEEVSIKEIAITHHVK 57
L ++ + + ++ P +E I ++ P + E P T + ++ I
Sbjct: 584 LGEIDESSELRVLDIPGQDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQE--L 641
Query: 58 EGHEKADPSQFEL-----LKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDR 112
E QF L VLG+G FGKV L + + +++A+K LKK + RD
Sbjct: 642 EDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEY---KNTNEMFAIKALKKGDIVARDE 698
Query: 113 VRTKM-ERDILVEVN---HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEE 168
V + M E+ I VN HPF+V L FQT+ + ++++ GGDL + +V F+E
Sbjct: 699 VDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDV-FSEP 757
Query: 169 DVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSF 228
FY A + L L +LH I+YRDLK +N+LLD EG +K+ DFGL KE + + + +F
Sbjct: 758 RAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTF 817
Query: 229 CGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMP 288
CGT E++APEV+ +T++ DWW GVL++EML G PF G D +E I+ ++ P
Sbjct: 818 CGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYP 877
Query: 289 QFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPAT 348
+FLS EA S++R L +RNP RLGA E++K+H FF IDW+ L +++ PPF P
Sbjct: 878 RFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTI 937
Query: 349 GRPEDTFYFDPEFTAKTPKDSPGIPP---SANAHQLFRGFSFVA 389
ED FD EFT++ P +P P S ++FR F ++A
Sbjct: 938 RGREDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDFDYIA 981
Score = 110 bits (275), Expect = 5e-24
Identities = 91/345 (26%), Positives = 152/345 (44%), Gaps = 29/345 (8%)
Query: 393 DDESQAMQTVGVHSIVQQLHRNSIQFT-DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVK 451
D ++ G+ + + + QF + +G G + +K TN FA+K
Sbjct: 627 DTPQSGLEYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIK 686
Query: 452 IIDKSKRDPTEEIEILL---------RYGQHPNIITLKDVYDDGKYVYVVTELMKGGELL 502
+ K +E++ L+ +HP ++ L + ++V V E GG+L+
Sbjct: 687 ALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLM 746
Query: 503 DKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDF 562
I FSE A + ++YLH +V+RDLK N+L +D G ++I DF
Sbjct: 747 MHI-HTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLL-LDTEG---FVKIADF 801
Query: 563 GFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGP 622
G K+ T C T F+APEVL Y A D W LGVL+Y ML G +PF P
Sbjct: 802 GLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPF---P 858
Query: 623 DDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAAL-----VLRHP 677
D EE+ I + + Y +S A ++ ++L +P +RL A+ V +HP
Sbjct: 859 GDDEEEVFDSIVNDEVR----YPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHP 914
Query: 678 W--IVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEP 720
+ ++ W L ++ P + + + +++P+L P
Sbjct: 915 FFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEFTSEAPILTP 959
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 256 bits (654), Expect = 5e-68
Identities = 138/329 (41%), Positives = 199/329 (60%), Gaps = 12/329 (3%)
Query: 66 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVR-TKMERDILVE 124
+ F L VLG+GSFGKV L + +LYA+K+LKK + D V T +E+ +L
Sbjct: 337 TDFNFLMVLGKGSFGKVMLADR---KGTEELYAIKILKKDVVIQDDDVECTMVEKRVLAL 393
Query: 125 VNHP-FIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDH 183
++ P F+ +LH FQT +LY +++++ GGDL + + F E FY AE+++ L
Sbjct: 394 LDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFF 453
Query: 184 LHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRR 243
LH GIIYRDLK +N++LD EGHIK+ DFG+ KE + +FCGT +Y+APE++ +
Sbjct: 454 LHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQ 513
Query: 244 GHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLF 303
+ +S DWW++GVL++EML G PF G+D E I++ + P+ LS EA S+ + L
Sbjct: 514 PYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLM 573
Query: 304 KRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKP-ATGRPEDTF--YFDPE 360
++PA RLG GP+G +++ H+FF IDW KL REI PPFKP G+ + F +F
Sbjct: 574 TKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRG 633
Query: 361 FTAKTPKDSPGIPPSANAHQL-FRGFSFV 388
TP D I AN Q F GFS+V
Sbjct: 634 QPVLTPPDQLVI---ANIDQSDFEGFSYV 659
Score = 102 bits (254), Expect = 1e-21
Identities = 85/314 (27%), Positives = 142/314 (45%), Gaps = 26/314 (8%)
Query: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIE-------ILLRYGQHPNIITLK 480
+G GS+ K T +A+KI+ K +++E +L + P + L
Sbjct: 345 LGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLH 404
Query: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540
+ +Y V E + GG+L+ I + F E +A I+ + +LH +G+++RDL
Sbjct: 405 SCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDL 464
Query: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD 600
K N++ +D G+ I+I DFG K+ + T C T +++APE++ Q Y + D
Sbjct: 465 KLDNVM-LDSEGH---IKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVD 520
Query: 601 IWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKML 660
W+ GVLLY ML G PF +G D+ +E+ I S Y S+S A + ++
Sbjct: 521 WWAYGVLLYEMLAGQPPF-DGEDE--DELFQSIMEHNVS----YPKSLSKEAVSICKGLM 573
Query: 661 HVDPHQRLTAAL-----VLRHPWI--VHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRN 713
P +RL V H + + W++L ++ P V G A +
Sbjct: 574 TKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPK-VCGKGAENFDKFFTR 632
Query: 714 QSPVLEPVGRSTLA 727
PVL P + +A
Sbjct: 633 GQPVLTPPDQLVIA 646
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,133,354
Number of Sequences: 37866
Number of extensions: 1300192
Number of successful extensions: 7699
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 742
Number of HSP's successfully gapped in prelim test: 78
Number of HSP's that attempted gapping in prelim test: 2877
Number of HSP's gapped (non-prelim): 1888
length of query: 740
length of database: 18,247,518
effective HSP length: 110
effective length of query: 630
effective length of database: 14,082,258
effective search space: 8871822540
effective search space used: 8871822540
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.