Search of human proteins with 4755125

Search of human proteins with 4755125

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4755125 aquaporin 4 isoform b [Homo sapiens]
         (301 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4755125 aquaporin 4 isoform b [Homo sapiens]                       604   e-173
gi|4502181 aquaporin 4 isoform a [Homo sapiens]                       604   e-173
gi|4502183 aquaporin 5 [Homo sapiens]                                 238   5e-63
gi|6912506 major intrinsic protein of lens fiber [Homo sapiens]       237   1e-62
gi|4502179 aquaporin 2 [Homo sapiens]                                 233   2e-61
gi|37694062 aquaporin 1 [Homo sapiens]                                216   2e-56
gi|86792455 aquaporin 6 [Homo sapiens]                                196   3e-50
gi|45446752 aquaporin 8 [Homo sapiens]                                117   1e-26
gi|157266307 aquaporin 9 [Homo sapiens]                                87   2e-17
gi|4826645 aquaporin 3 [Homo sapiens]                                  83   3e-16
gi|4502187 aquaporin 7 [Homo sapiens]                                  83   3e-16
gi|22538420 aquaporin 10 [Homo sapiens]                                69   5e-12
gi|7019415 Sec61 alpha 1 subunit [Homo sapiens]                        35   0.062
gi|83921614 cytochrome b5 outer mitochondrial membrane precursor...    35   0.062
gi|217330618 Sec61 alpha form 2 isoform b [Homo sapiens]               33   0.24 
gi|217330616 Sec61 alpha form 2 isoform c [Homo sapiens]               33   0.24 
gi|14589847 Sec61 alpha form 2 isoform a [Homo sapiens]                33   0.24 
gi|40538880 aquaporin 12A [Homo sapiens]                               33   0.40 
gi|50593008 transmembrane BAX inhibitor motif containing 1 [Homo...    32   0.69 
gi|156447037 aquaporin 12B [Homo sapiens]                              32   0.69 
gi|112799849 tumor protein p53 binding protein, 2 isoform 1 [Hom...    31   1.5  
gi|4885643 tumor protein p53 binding protein, 2 isoform 2 [Homo ...    31   1.5  
gi|39995086 solute carrier family 24 member 6 [Homo sapiens]           30   2.6  
gi|157694513 leucine-rich repeat-containing G protein-coupled re...    29   4.4  
gi|60460889 Myb protein P42POP [Homo sapiens]                          29   5.8  
gi|121114287 apoptosis-stimulating protein of p53, 1 [Homo sapiens]    29   5.8  
gi|29171306 solute carrier family 13, member 5 isoform a [Homo s...    28   9.9  
gi|209863034 periostin, osteoblast specific factor isoform 4 [Ho...    28   9.9  
gi|209863011 periostin, osteoblast specific factor isoform 3 [Ho...    28   9.9  
gi|209862911 periostin, osteoblast specific factor isoform 2 [Ho...    28   9.9  

>gi|4755125 aquaporin 4 isoform b [Homo sapiens]
          Length = 301

 Score =  604 bits (1557), Expect = e-173
 Identities = 301/301 (100%), Positives = 301/301 (100%)

Query: 1   MVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIA 60
           MVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIA
Sbjct: 1   MVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIA 60

Query: 61  TMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVV 120
           TMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVV
Sbjct: 61  TMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVV 120

Query: 121 GGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHL 180
           GGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHL
Sbjct: 121 GGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHL 180

Query: 181 FAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRF 240
           FAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRF
Sbjct: 181 FAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRF 240

Query: 241 KEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSS 300
           KEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSS
Sbjct: 241 KEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSS 300

Query: 301 V 301
           V
Sbjct: 301 V 301


>gi|4502181 aquaporin 4 isoform a [Homo sapiens]
          Length = 323

 Score =  604 bits (1557), Expect = e-173
 Identities = 301/301 (100%), Positives = 301/301 (100%)

Query: 1   MVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIA 60
           MVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIA
Sbjct: 23  MVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIA 82

Query: 61  TMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVV 120
           TMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVV
Sbjct: 83  TMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVV 142

Query: 121 GGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHL 180
           GGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHL
Sbjct: 143 GGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHL 202

Query: 181 FAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRF 240
           FAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRF
Sbjct: 203 FAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRF 262

Query: 241 KEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSS 300
           KEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSS
Sbjct: 263 KEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSS 322

Query: 301 V 301
           V
Sbjct: 323 V 323


>gi|4502183 aquaporin 5 [Homo sapiens]
          Length = 265

 Score =  238 bits (607), Expect = 5e-63
 Identities = 132/263 (50%), Positives = 170/263 (64%), Gaps = 12/263 (4%)

Query: 5   KGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQ 64
           K V + AF KAV AEFLA LIFV   LGS + W      LP  ++ I+L FGL+I T+ Q
Sbjct: 3   KEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSA---LPT-ILQIALAFGLAIGTLAQ 58

Query: 65  CFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLG 124
             G +SGGHINPA+T+A++   +IS+ ++ FY+AAQ +GAI GAGILY V P +  G L 
Sbjct: 59  ALGPVSGGHINPAITLALLVGNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLA 118

Query: 125 VTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAIN 184
           V  ++ N T G  ++VELI+TFQL   IFAS DS+RT   GS AL+IG SV +GHL  I 
Sbjct: 119 VNALNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPVGSPALSIGLSVTLGHLVGIY 178

Query: 185 YTGASMNPARSFGPAVIMGNWE-NHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRFKEA 243
           +TG SMNPARSFGPAV+M  +   HW++WVGPI+GAVLA  LY Y+  P+         +
Sbjct: 179 FTGCSMNPARSFGPAVVMNRFSPAHWVFWVGPIVGAVLAAILYFYLLFPN-------SLS 231

Query: 244 FSKAAQQTKGSYMEVEDNRSQVE 266
            S+     KG+Y   ED   Q E
Sbjct: 232 LSERVAIIKGTYEPDEDWEEQRE 254


>gi|6912506 major intrinsic protein of lens fiber [Homo sapiens]
          Length = 263

 Score =  237 bits (604), Expect = 1e-62
 Identities = 113/255 (44%), Positives = 168/255 (65%), Gaps = 11/255 (4%)

Query: 11  AFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHIS 70
           +FW+A+ AEF A L +V   LGS++ W     P P+ ++ +++ FGL++AT+VQ  GHIS
Sbjct: 8   SFWRAIFAEFFATLFYVFFGLGSSLRWA----PGPLHVLQVAMAFGLALATLVQSVGHIS 63

Query: 71  GGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHG 130
           G H+NPAVT A +   ++S+ ++  Y+AAQ LGA+ GA +LY VTPP+V G L +  +H 
Sbjct: 64  GAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHP 123

Query: 131 NLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASM 190
            ++ G    VE+ +T Q V  IFA+ D +R    GS+ALA+GFS+A+GHLF + YTGA M
Sbjct: 124 AVSVGQATTVEIFLTLQFVLCIFATYDERRNGQLGSVALAVGFSLALGHLFGMYYTGAGM 183

Query: 191 NPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQ 250
           NPARSF PA++ GN+ NHW+YWVGPIIG  L   LY+++  P +       ++ S+    
Sbjct: 184 NPARSFAPAILTGNFTNHWVYWVGPIIGGGLGSLLYDFLLFPRL-------KSISERLSV 236

Query: 251 TKGSYMEVEDNRSQV 265
            KG+  +V + + +V
Sbjct: 237 LKGAKPDVSNGQPEV 251


>gi|4502179 aquaporin 2 [Homo sapiens]
          Length = 271

 Score =  233 bits (593), Expect = 2e-61
 Identities = 114/222 (51%), Positives = 154/222 (69%), Gaps = 4/222 (1%)

Query: 11  AFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHIS 70
           AF +AV AEFLA L+FV   LGS +NW    + LP  ++ I++ FGL I T+VQ  GHIS
Sbjct: 8   AFSRAVFAEFLATLLFVFFGLGSALNW---PQALP-SVLQIAMAFGLGIGTLVQALGHIS 63

Query: 71  GGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHG 130
           G HINPAVTVA +    +S+ ++ FY+AAQ LGA+ GA +L+ +TP  + G L V  +  
Sbjct: 64  GAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNALSN 123

Query: 131 NLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASM 190
           + TAG  + VEL +T QLV  IFAS D +R +  G+ AL+IGFSVA+GHL  I+YTG SM
Sbjct: 124 STTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTGCSM 183

Query: 191 NPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCP 232
           NPARS  PAV+ G +++HW++W+GP++GA+L   LY YV  P
Sbjct: 184 NPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFP 225


>gi|37694062 aquaporin 1 [Homo sapiens]
          Length = 269

 Score =  216 bits (550), Expect = 2e-56
 Identities = 109/224 (48%), Positives = 148/224 (66%), Gaps = 3/224 (1%)

Query: 12  FWKAVTAEFLAMLIFVLLSLGSTINWG---GTEKPLPVDMVLISLCFGLSIATMVQCFGH 68
           FW+AV AEFLA  +FV +S+GS + +    G  +    D V +SL FGLSIAT+ Q  GH
Sbjct: 10  FWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATLAQSVGH 69

Query: 69  ISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMV 128
           ISG H+NPAVT+ ++ + +ISI +++ YI AQC+GAI+   IL  +T       LG   +
Sbjct: 70  ISGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLTGNSLGRNDL 129

Query: 129 HGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGA 188
              + +G GL +E+I T QLV  + A+ D +R D+ GS  LAIG SVA+GHL AI+YTG 
Sbjct: 130 ADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGC 189

Query: 189 SMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCP 232
            +NPARSFG AVI  N+ NHWI+WVGP IG  LA  +Y+++  P
Sbjct: 190 GINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFILAP 233


>gi|86792455 aquaporin 6 [Homo sapiens]
          Length = 282

 Score =  196 bits (497), Expect = 3e-50
 Identities = 103/228 (45%), Positives = 148/228 (64%), Gaps = 12/228 (5%)

Query: 13  WKAVT----AEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVL-ISLCFGLSIATMVQCFG 67
           WKA++    AEFLA  ++V   +GS + W     P  +  VL I++ F L  A  VQ   
Sbjct: 20  WKAISRALFAEFLATGLYVFFGVGSVMRW-----PTALPSVLQIAITFNLVTAMAVQVTW 74

Query: 68  HISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTM 127
             SG H NPAVT+A +    IS+ ++V Y+AAQ +GA +GA +LY V P  +   LG+ +
Sbjct: 75  KASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATVGAALLYGVMPGDIRETLGINV 134

Query: 128 VHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTG 187
           V  +++ G  + VEL++T QLV  +FAS DS++T  +GS A  IG SVA+GHL  I++TG
Sbjct: 135 VRNSVSTGQAVAVELLLTLQLVLCVFASTDSRQT--SGSPATMIGISVALGHLIGIHFTG 192

Query: 188 ASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVE 235
            SMNPARSFGPA+I+G +  HW++WVGP++GA+LA  +Y +V  PD +
Sbjct: 193 CSMNPARSFGPAIIIGKFTVHWVFWVGPLMGALLASLIYNFVLFPDTK 240


>gi|45446752 aquaporin 8 [Homo sapiens]
          Length = 261

 Score =  117 bits (294), Expect = 1e-26
 Identities = 74/221 (33%), Positives = 116/221 (52%), Gaps = 13/221 (5%)

Query: 8   WTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFG 67
           W + F +    E L   +F+ +   S I   GT+  L    +   L  GL IAT+    G
Sbjct: 30  WYERFVQPCLVELLGSALFIFIGCLSVIE-NGTDTGLLQPALAHGLALGLVIATL----G 84

Query: 68  HISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPP----SVVGGL 123
           +ISGGH NPAV++A +    +++   + Y  +Q LG ++GA +   V+P     +  G  
Sbjct: 85  NISGGHFNPAVSLAAMLIGGLNLVMLLPYWVSQLLGGMLGAALAKAVSPEERFWNASGAA 144

Query: 124 GVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIA-LAIGFSVAIGHLFA 182
            VT+      AG  L+ E+I+T  L   +     +++T   G +A  +IGF+V +  L  
Sbjct: 145 FVTVQEQGQVAG-ALVAEIILTTLLALAVCMGAINEKTK--GPLAPFSIGFAVTVDILAG 201

Query: 183 INYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAG 223
              +G  MNPAR+FGPAV+  +W  HWIYW+GP++  +L G
Sbjct: 202 GPVSGGCMNPARAFGPAVVANHWNFHWIYWLGPLLAGLLVG 242


>gi|157266307 aquaporin 9 [Homo sapiens]
          Length = 295

 Score = 86.7 bits (213), Expect = 2e-17
 Identities = 77/269 (28%), Positives = 118/269 (43%), Gaps = 49/269 (18%)

Query: 14  KAVTAEFLAMLIFVLLSLG-------STINWGGTEKPLPVDMVLISLCFGLSIATMVQCF 66
           K   +EFL   I ++L  G       S   +GG        ++ I++ F +++A  +   
Sbjct: 24  KETLSEFLGTFILIVLGCGCVAQAILSRGRFGG--------VITINVGFSMAVAMAIYVA 75

Query: 67  GHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGA----GILY---------- 112
           G +SGGHINPAV++AM    ++   K  FY+ AQ LGA +GA    GI Y          
Sbjct: 76  GGVSGGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATVFGIYYDGLMSFAGGK 135

Query: 113 -LVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDV-TGSIALA 170
            L+   +    +  T     L+  +    +++ T  L+  +FA  DS+      G   +A
Sbjct: 136 LLIVGENATAHIFATYPAPYLSLANAFADQVVATMILLIIVFAIFDSRNLGAPRGLEPIA 195

Query: 171 IG-FSVAIGHLFAINYTGASMNPARSFGPAVI--MGNW---------ENHWIYWVGPIIG 218
           IG   + I     +N +G +MNPAR   P +   +  W            WI  VGP++G
Sbjct: 196 IGLLIIVIASSLGLN-SGCAMNPARDLSPRLFTALAGWGFEVFRAGNNFWWIPVVGPLVG 254

Query: 219 AVLAGGLYEYVF-----CPDVEFKRRFKE 242
           AV+ G +Y  V       PD  FK    E
Sbjct: 255 AVIGGLIYVLVIEIHHPEPDSVFKTEQSE 283


>gi|4826645 aquaporin 3 [Homo sapiens]
          Length = 292

 Score = 82.8 bits (203), Expect = 3e-16
 Identities = 72/242 (29%), Positives = 107/242 (44%), Gaps = 38/242 (15%)

Query: 18  AEFLAMLIFVLLSLGST---INWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHI 74
           AE L  LI V+   GS    +   GT        + I+L FG ++   +   G +SG H+
Sbjct: 27  AECLGTLILVMFGCGSVAQVVLSRGTHG----GFLTINLAFGFAVTLGILIAGQVSGAHL 82

Query: 75  NPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILY---------------LVTPPSV 119
           NPAVT AM    +    K   Y  AQ LGA +GAGI++                V+ P+ 
Sbjct: 83  NPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIWHFADNQLFVSGPNG 142

Query: 120 VGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDV-TGSIALAIGFSV-AI 177
             G+  T   G+L   +G   + I T  L+  + A  D     V  G  A  +G  V  I
Sbjct: 143 TAGIFATYPSGHLDMINGFFDQFIGTASLIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVI 202

Query: 178 GHLFAINYTGASMNPARSFGPAVI--MGNWEN-------HWIYW---VGPIIGAVLAGGL 225
           G     N +G ++NPAR FGP +   +  W +       HW +W   V P++G++    +
Sbjct: 203 GTSMGFN-SGYAVNPARDFGPRLFTALAGWGSAVFTTGQHW-WWVPIVSPLLGSIAGVFV 260

Query: 226 YE 227
           Y+
Sbjct: 261 YQ 262


>gi|4502187 aquaporin 7 [Homo sapiens]
          Length = 342

 Score = 82.8 bits (203), Expect = 3e-16
 Identities = 66/236 (27%), Positives = 104/236 (44%), Gaps = 29/236 (12%)

Query: 18  AEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPA 77
           AEF++  + ++  LGS  +    +K      + ++L FG  +   V   G ISG H+N A
Sbjct: 39  AEFMSTYVMMVFGLGSVAHMVLNKKY--GSYLGVNLGFGFGVTMGVHVAGRISGAHMNAA 96

Query: 78  VTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILY---------------LVTPPSVVGG 122
           VT A     ++   K   Y+  Q LG+ + A  +Y               +VT P    G
Sbjct: 97  VTFANCALGRVPWRKFPVYVLGQFLGSFLAAATIYSLFYTAILHFSGGQLMVTGPVATAG 156

Query: 123 LGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTD-VTGSIALAIGFSVAIGHLF 181
           +  T +  ++T   G L E  +T  L   +FA  D +    + G+ AL IG  V I  + 
Sbjct: 157 IFATYLPDHMTLWRGFLNEAWLTGMLQLCLFAITDQENNPALPGTEALVIGILVVIIGVS 216

Query: 182 AINYTGASMNPARSFGPAV----------IMGNWEN-HWIYWVGPIIGAVLAGGLY 226
               TG ++NP+R   P +          +  N EN  W+  V P++GA L G +Y
Sbjct: 217 LGMNTGYAINPSRDLPPRIFTFIAGWGKQVFSNGENWWWVPVVAPLLGAYLGGIIY 272


>gi|22538420 aquaporin 10 [Homo sapiens]
          Length = 301

 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 58/244 (23%), Positives = 97/244 (39%), Gaps = 42/244 (17%)

Query: 18  AEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPA 77
           AEFL + + +LL+ G+      T      +   + L   L++   +   G++SG H+NPA
Sbjct: 26  AEFLGVFVLMLLTQGAVAQ-AVTSGETKGNFFTMFLAGSLAVTIAIYVGGNVSGAHLNPA 84

Query: 78  VTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYL---------------VTPPSVVGG 122
            ++AM    ++   K   YI  Q L A   +G  Y+               VT P     
Sbjct: 85  FSLAMCIVGRLPWVKLPIYILVQLLSAFCASGATYVLYHDALQNYTGGNLTVTGPKETAS 144

Query: 123 LGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTD--------VTGSIALAIGFS 174
           +  T     L+  +G L +++ T  L+  + A  D +           V G + LA+G S
Sbjct: 145 IFATYPAPYLSLNNGFLDQVLGTGMLIVGLLAILDRRNKGVPAGLEPVVVGMLILALGLS 204

Query: 175 VAIGHLFAINYTGASMNPARSFGPAVI--MGNWENH---------WIYWVGPIIGAVLAG 223
           +           G  +NPAR  GP +   +  W            W+  V P++GA +  
Sbjct: 205 MGAN-------CGIPLNPARDLGPRLFTYVAGWGPEVFSAGNGWWWVPVVAPLVGATVGT 257

Query: 224 GLYE 227
             Y+
Sbjct: 258 ATYQ 261



 Score = 28.9 bits (63), Expect = 5.8
 Identities = 32/129 (24%), Positives = 49/129 (37%), Gaps = 33/129 (25%)

Query: 97  IAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASC 156
           +A QCL   +G  +L L+T  +V   +      GN                  FT+F   
Sbjct: 20  LARQCLAEFLGVFVLMLLTQGAVAQAVTSGETKGNF-----------------FTMF--- 59

Query: 157 DSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVI-MGNWENHWIYWVGP 215
                 + GS+A+ I   V        N +GA +NPA S    ++    W    IY +  
Sbjct: 60  ------LAGSLAVTIAIYV------GGNVSGAHLNPAFSLAMCIVGRLPWVKLPIYILVQ 107

Query: 216 IIGAVLAGG 224
           ++ A  A G
Sbjct: 108 LLSAFCASG 116


>gi|7019415 Sec61 alpha 1 subunit [Homo sapiens]
          Length = 476

 Score = 35.4 bits (80), Expect = 0.062
 Identities = 32/99 (32%), Positives = 46/99 (46%), Gaps = 4/99 (4%)

Query: 88  ISIAKSVFYIAAQCLG--AIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGL--LVELI 143
           I+I +S+ Y+     G  + +GAGI  L+T    V GL V ++   L  G+GL   + L 
Sbjct: 123 ITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLF 182

Query: 144 ITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFA 182
           I   +  TI     S  T  TG      G  +A+ HL A
Sbjct: 183 IATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLA 221


>gi|83921614 cytochrome b5 outer mitochondrial membrane precursor
           [Homo sapiens]
          Length = 150

 Score = 35.4 bits (80), Expect = 0.062
 Identities = 14/20 (70%), Positives = 15/20 (75%)

Query: 209 WIYWVGPIIGAVLAGGLYEY 228
           W YW+ PIIGAVL G LY Y
Sbjct: 123 WAYWILPIIGAVLLGFLYRY 142


>gi|217330618 Sec61 alpha form 2 isoform b [Homo sapiens]
          Length = 454

 Score = 33.5 bits (75), Expect = 0.24
 Identities = 31/99 (31%), Positives = 45/99 (45%), Gaps = 4/99 (4%)

Query: 88  ISIAKSVFYIAAQCLG--AIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGL--LVELI 143
           I+I +++ Y+     G  A +GAGI  L+     V GL V ++   L  G+GL   + L 
Sbjct: 101 ITIGQAIVYVMTGMYGDPAEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGISLF 160

Query: 144 ITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFA 182
           I   +  TI     S  T  TG      G  +A+ HL A
Sbjct: 161 IATNICETIVWKAFSPTTINTGRGTEFEGAVIALFHLLA 199


>gi|217330616 Sec61 alpha form 2 isoform c [Homo sapiens]
          Length = 437

 Score = 33.5 bits (75), Expect = 0.24
 Identities = 31/99 (31%), Positives = 45/99 (45%), Gaps = 4/99 (4%)

Query: 88  ISIAKSVFYIAAQCLG--AIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGL--LVELI 143
           I+I +++ Y+     G  A +GAGI  L+     V GL V ++   L  G+GL   + L 
Sbjct: 123 ITIGQAIVYVMTGMYGDPAEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGISLF 182

Query: 144 ITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFA 182
           I   +  TI     S  T  TG      G  +A+ HL A
Sbjct: 183 IATNICETIVWKAFSPTTINTGRGTEFEGAVIALFHLLA 221


>gi|14589847 Sec61 alpha form 2 isoform a [Homo sapiens]
          Length = 476

 Score = 33.5 bits (75), Expect = 0.24
 Identities = 31/99 (31%), Positives = 45/99 (45%), Gaps = 4/99 (4%)

Query: 88  ISIAKSVFYIAAQCLG--AIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGL--LVELI 143
           I+I +++ Y+     G  A +GAGI  L+     V GL V ++   L  G+GL   + L 
Sbjct: 123 ITIGQAIVYVMTGMYGDPAEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGISLF 182

Query: 144 ITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFA 182
           I   +  TI     S  T  TG      G  +A+ HL A
Sbjct: 183 IATNICETIVWKAFSPTTINTGRGTEFEGAVIALFHLLA 221


>gi|40538880 aquaporin 12A [Homo sapiens]
          Length = 295

 Score = 32.7 bits (73), Expect = 0.40
 Identities = 46/189 (24%), Positives = 75/189 (39%), Gaps = 18/189 (9%)

Query: 49  VLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGA 108
           +L++L F L +A  V     + G   NP V++      + S+  ++  +AAQ LG     
Sbjct: 59  LLLTLLFLLFLAHGVT----LDGASANPTVSLQEFLMAEQSLPGTLLKLAAQGLGMQAAC 114

Query: 109 GILYL-----VTPPSVVGGLGVTMVHGNLTAG--HGLLVELIITFQLVFTIFASCDSKRT 161
            ++ L     ++   ++  L        L     HG LVE    F    T+     S   
Sbjct: 115 TLMRLCWAWELSDLHLLQSLMAQSCSSALRTSVPHGALVEAACAFCFHLTLLHLRHSPPA 174

Query: 162 DVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNW---ENHWIYWVGPIIG 218
               ++AL     V +    A  +T A  NPA +             E   +YW+GP+ G
Sbjct: 175 YSGPAVALL----VTVTAYTAGPFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPLTG 230

Query: 219 AVLAGGLYE 227
            VLA  L++
Sbjct: 231 MVLAVLLHQ 239


>gi|50593008 transmembrane BAX inhibitor motif containing 1 [Homo
           sapiens]
          Length = 311

 Score = 32.0 bits (71), Expect = 0.69
 Identities = 24/82 (29%), Positives = 41/82 (50%), Gaps = 9/82 (10%)

Query: 39  GTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIA 98
           G  +  P +++L++L F  ++  M    G IS  +   AV +AM+ T  +SI+ ++F   
Sbjct: 156 GPRRRFPWNIILLTL-FTFAMGFMT---GTISSMYQTKAVIIAMIITAVVSISVTIFCFQ 211

Query: 99  AQ-----CLGAIIGAGILYLVT 115
            +     C G     GI+ LVT
Sbjct: 212 TKVDFTSCTGLFCVLGIVLLVT 233


>gi|156447037 aquaporin 12B [Homo sapiens]
          Length = 307

 Score = 32.0 bits (71), Expect = 0.69
 Identities = 54/224 (24%), Positives = 85/224 (37%), Gaps = 22/224 (9%)

Query: 14  KAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGH 73
           +AV A  L      + +L     W G   P     +L++L F L +A  V     + G  
Sbjct: 40  EAVGAVQLGACFLEMRTLVELGPWAGDFGP----DLLLTLLFLLFLAHGVT----LDGAS 91

Query: 74  INPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYL-----VTPPSVVGGLGVTMV 128
            NP V++      + S+  ++  +AAQ LG      +  L     ++   ++  L     
Sbjct: 92  ANPTVSLQEFLMAEESLPGTLLKLAAQGLGMQAACTLTRLCWAWELSDLHLLQSLMAQSC 151

Query: 129 HGNLTAG--HGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYT 186
              L     HG LVE    F    T+     S       ++AL     V +    A  +T
Sbjct: 152 SSALRTSVPHGALVEAACAFCFHLTLLHLRHSPPAYSGPAVALL----VTVTAYTAGPFT 207

Query: 187 GASMNPARSFGPAVIMGNW---ENHWIYWVGPIIGAVLAGGLYE 227
            A  NPA +             E   +YW+GP+ G VLA  L++
Sbjct: 208 SAFFNPALAASVTFACSGHTLLEYVQVYWLGPLTGMVLAVLLHQ 251


>gi|112799849 tumor protein p53 binding protein, 2 isoform 1 [Homo
           sapiens]
          Length = 1134

 Score = 30.8 bits (68), Expect = 1.5
 Identities = 13/37 (35%), Positives = 22/37 (59%)

Query: 110 ILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITF 146
           I+Y V  PS+    G+T +H  + AGH  +V+ ++ F
Sbjct: 951 IIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQF 987


>gi|4885643 tumor protein p53 binding protein, 2 isoform 2 [Homo
           sapiens]
          Length = 1005

 Score = 30.8 bits (68), Expect = 1.5
 Identities = 13/37 (35%), Positives = 22/37 (59%)

Query: 110 ILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITF 146
           I+Y V  PS+    G+T +H  + AGH  +V+ ++ F
Sbjct: 822 IIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQF 858


>gi|39995086 solute carrier family 24 member 6 [Homo sapiens]
          Length = 584

 Score = 30.0 bits (66), Expect = 2.6
 Identities = 24/84 (28%), Positives = 40/84 (47%), Gaps = 9/84 (10%)

Query: 90  IAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLV 149
           +A S  + A   LGA+ GAG+L      +VV G G+T++H  + A      +++     V
Sbjct: 159 VAFSDPHTAGLALGALFGAGVLV----TTVVAG-GITILHPFMAASRPFFRDIVFYMVAV 213

Query: 150 FTIFASCDSKRTDVTGSIALAIGF 173
           F  F      R     ++A A+G+
Sbjct: 214 FLTFLMLFRGRV----TLAWALGY 233


>gi|157694513 leucine-rich repeat-containing G protein-coupled
           receptor 4 [Homo sapiens]
          Length = 951

 Score = 29.3 bits (64), Expect = 4.4
 Identities = 29/90 (32%), Positives = 39/90 (43%), Gaps = 13/90 (14%)

Query: 123 LGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFA 182
           LG  M+   LT     LV L     ++ T FASC S       S  L IG  +++ +LF 
Sbjct: 536 LGSWMIR--LTVWFIFLVALFFNLLVILTTFASCTS-----LPSSKLFIGL-ISVSNLFM 587

Query: 183 INYTGASMNPARSFGPAVIMGNWENHWIYW 212
             YTG       +F  AV  G +    I+W
Sbjct: 588 GIYTG-----ILTFLDAVSWGRFAEFGIWW 612


>gi|60460889 Myb protein P42POP [Homo sapiens]
          Length = 399

 Score = 28.9 bits (63), Expect = 5.8
 Identities = 18/43 (41%), Positives = 24/43 (55%), Gaps = 1/43 (2%)

Query: 235 EFKRRFKEAFSKAAQQTKGSYMEVEDNRS-QVETDDLILKPGV 276
           +FKRR KE  ++    T+G+    ED  S + ET   IL PGV
Sbjct: 82  DFKRRTKEKLARVPHSTQGAGPAAEDAFSAEEETIFAILGPGV 124


>gi|121114287 apoptosis-stimulating protein of p53, 1 [Homo sapiens]
          Length = 1090

 Score = 28.9 bits (63), Expect = 5.8
 Identities = 13/37 (35%), Positives = 21/37 (56%)

Query: 110 ILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITF 146
           I+Y V  PS     G+T +H  + AGH  +V+ ++ F
Sbjct: 907 IIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDF 943


>gi|29171306 solute carrier family 13, member 5 isoform a [Homo
           sapiens]
          Length = 568

 Score = 28.1 bits (61), Expect = 9.9
 Identities = 34/158 (21%), Positives = 62/158 (39%), Gaps = 22/158 (13%)

Query: 13  WKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDM------------VLISLCFGLSIA 60
           WK VT E +   I +LL  G  +  G     L V M              I+L   L +A
Sbjct: 399 WK-VTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVA 457

Query: 61  TMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVV 120
              +C  +++       + + +  +   SI  +  YI   C  +   A +L + TPP+  
Sbjct: 458 VFTECTSNVA----TTTLFLPIFASMSRSIGLNPLYIMLPCTLSASFAFMLPVATPPN-- 511

Query: 121 GGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS 158
               +   +G+L     +   +I+    VF +F + ++
Sbjct: 512 ---AIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNT 546


>gi|209863034 periostin, osteoblast specific factor isoform 4 [Homo
           sapiens]
          Length = 751

 Score = 28.1 bits (61), Expect = 9.9
 Identities = 22/83 (26%), Positives = 39/83 (46%), Gaps = 9/83 (10%)

Query: 228 YVFCPDVEFKRRFKEAFSKAAQQTKGSYM---EVED----NRSQVETDDLILKPGVVHVI 280
           Y   P V   + F+   +   + T+GS +   EV D    N  + +  D++   GV+HV+
Sbjct: 565 YHLTPGVFIGKGFEPGVTNILKTTQGSKIFLKEVNDTLLVNELKSKESDIMTTNGVIHVV 624

Query: 281 D--VDRGEEKKGKDQSGEVLSSV 301
           D  +   +   G DQ  E+L+ +
Sbjct: 625 DKLLYPADTPVGNDQLLEILNKL 647


>gi|209863011 periostin, osteoblast specific factor isoform 3 [Homo
           sapiens]
          Length = 781

 Score = 28.1 bits (61), Expect = 9.9
 Identities = 22/83 (26%), Positives = 39/83 (46%), Gaps = 9/83 (10%)

Query: 228 YVFCPDVEFKRRFKEAFSKAAQQTKGSYM---EVED----NRSQVETDDLILKPGVVHVI 280
           Y   P V   + F+   +   + T+GS +   EV D    N  + +  D++   GV+HV+
Sbjct: 565 YHLTPGVFIGKGFEPGVTNILKTTQGSKIFLKEVNDTLLVNELKSKESDIMTTNGVIHVV 624

Query: 281 D--VDRGEEKKGKDQSGEVLSSV 301
           D  +   +   G DQ  E+L+ +
Sbjct: 625 DKLLYPADTPVGNDQLLEILNKL 647


>gi|209862911 periostin, osteoblast specific factor isoform 2 [Homo
           sapiens]
          Length = 779

 Score = 28.1 bits (61), Expect = 9.9
 Identities = 22/83 (26%), Positives = 39/83 (46%), Gaps = 9/83 (10%)

Query: 228 YVFCPDVEFKRRFKEAFSKAAQQTKGSYM---EVED----NRSQVETDDLILKPGVVHVI 280
           Y   P V   + F+   +   + T+GS +   EV D    N  + +  D++   GV+HV+
Sbjct: 565 YHLTPGVFIGKGFEPGVTNILKTTQGSKIFLKEVNDTLLVNELKSKESDIMTTNGVIHVV 624

Query: 281 D--VDRGEEKKGKDQSGEVLSSV 301
           D  +   +   G DQ  E+L+ +
Sbjct: 625 DKLLYPADTPVGNDQLLEILNKL 647


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.427 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,659,003
Number of Sequences: 37866
Number of extensions: 433803
Number of successful extensions: 1192
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 1151
Number of HSP's gapped (non-prelim): 39
length of query: 301
length of database: 18,247,518
effective HSP length: 102
effective length of query: 199
effective length of database: 14,385,186
effective search space: 2862652014
effective search space used: 2862652014
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.