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Search of human proteins with 47419930
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47419930 chondroitin sulfate proteoglycan 4 [Homo sapiens]
(2322 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47419930 chondroitin sulfate proteoglycan 4 [Homo sapiens] 4615 0.0
gi|239756382 PREDICTED: similar to KIAA1920 protein [Homo sapiens] 780 0.0
gi|239757979 PREDICTED: similar to chondroitin sulfate proteogly... 471 e-132
gi|169217335 PREDICTED: similar to chondroitin sulfate proteogly... 471 e-132
gi|239747036 PREDICTED: hypothetical protein XP_002344245 [Homo ... 471 e-132
gi|239747031 PREDICTED: hypothetical protein XP_002344244 [Homo ... 471 e-132
gi|79749430 FRAS1-related extracellular matrix protein 2 precurs... 207 1e-52
gi|169167211 PREDICTED: FRAS1 related extracellular matrix 3 [Ho... 203 2e-51
gi|169166904 PREDICTED: FRAS1 related extracellular matrix 3 [Ho... 203 2e-51
gi|169166334 PREDICTED: FRAS1 related extracellular matrix 3 [Ho... 202 4e-51
gi|122056683 FRAS1 related extracellular matrix 1 [Homo sapiens] 192 2e-48
gi|108773804 Fraser syndrome 1 [Homo sapiens] 172 3e-42
gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens] 79 4e-14
gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens] 75 1e-12
gi|14149613 neurexin 1 isoform alpha1 precursor [Homo sapiens] 72 5e-12
gi|208609951 neurexin 1 isoform alpha2 precursor [Homo sapiens] 67 2e-10
gi|21070969 neurexin 3 isoform 1 precursor [Homo sapiens] 60 2e-08
gi|54873613 agrin [Homo sapiens] 52 9e-06
gi|116284404 cell recognition protein CASPR4 isoform 1 [Homo sap... 51 2e-05
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 50 3e-05
gi|18640734 contactin associated protein-like 5 [Homo sapiens] 49 4e-05
gi|38788416 laminin, alpha 1 precursor [Homo sapiens] 49 7e-05
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 47 3e-04
gi|4505463 contactin associated protein 1 precursor [Homo sapiens] 45 6e-04
gi|33469931 EGF-like, fibronectin type III and laminin G domains... 45 6e-04
gi|33469929 EGF-like, fibronectin type III and laminin G domains... 45 6e-04
gi|4759146 slit homolog 2 [Homo sapiens] 45 8e-04
gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo s... 45 0.001
gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo sa... 45 0.001
gi|38045910 laminin alpha 3 subunit isoform 1 [Homo sapiens] 45 0.001
>gi|47419930 chondroitin sulfate proteoglycan 4 [Homo sapiens]
Length = 2322
Score = 4615 bits (11970), Expect = 0.0
Identities = 2322/2322 (100%), Positives = 2322/2322 (100%)
Query: 1 MQSGPRPPLPAPGLALALTLTMLARLASAASFFGENHLEVPVATALTDIDLQLQFSTSQP 60
MQSGPRPPLPAPGLALALTLTMLARLASAASFFGENHLEVPVATALTDIDLQLQFSTSQP
Sbjct: 1 MQSGPRPPLPAPGLALALTLTMLARLASAASFFGENHLEVPVATALTDIDLQLQFSTSQP 60
Query: 61 EALLLLAAGPADHLLLQLYSGRLQVRLVLGQEELRLQTPAETLLSDSIPHTVVLTVVEGW 120
EALLLLAAGPADHLLLQLYSGRLQVRLVLGQEELRLQTPAETLLSDSIPHTVVLTVVEGW
Sbjct: 61 EALLLLAAGPADHLLLQLYSGRLQVRLVLGQEELRLQTPAETLLSDSIPHTVVLTVVEGW 120
Query: 121 ATLSVDGFLNASSAVPGAPLEVPYGLFVGGTGTLGLPYLRGTSRPLRGCLHAATLNGRSL 180
ATLSVDGFLNASSAVPGAPLEVPYGLFVGGTGTLGLPYLRGTSRPLRGCLHAATLNGRSL
Sbjct: 121 ATLSVDGFLNASSAVPGAPLEVPYGLFVGGTGTLGLPYLRGTSRPLRGCLHAATLNGRSL 180
Query: 181 LRPLTPDVHEGCAEEFSASDDVALGFSGPHSLAAFPAWGTQDEGTLEFTLTTQSRQAPLA 240
LRPLTPDVHEGCAEEFSASDDVALGFSGPHSLAAFPAWGTQDEGTLEFTLTTQSRQAPLA
Sbjct: 181 LRPLTPDVHEGCAEEFSASDDVALGFSGPHSLAAFPAWGTQDEGTLEFTLTTQSRQAPLA 240
Query: 241 FQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLHNSVPVADGQPHEVSVHINAHRLEISV 300
FQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLHNSVPVADGQPHEVSVHINAHRLEISV
Sbjct: 241 FQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLHNSVPVADGQPHEVSVHINAHRLEISV 300
Query: 301 DQYPTHTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLTPEATNASLLGCMEDLSV 360
DQYPTHTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLTPEATNASLLGCMEDLSV
Sbjct: 301 DQYPTHTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLTPEATNASLLGCMEDLSV 360
Query: 361 NGQRRGLREALLTRNMAAGCRLEEEEYEDDAYGHYEAFSTLAPEAWPAMELPEPCVPEPG 420
NGQRRGLREALLTRNMAAGCRLEEEEYEDDAYGHYEAFSTLAPEAWPAMELPEPCVPEPG
Sbjct: 361 NGQRRGLREALLTRNMAAGCRLEEEEYEDDAYGHYEAFSTLAPEAWPAMELPEPCVPEPG 420
Query: 421 LPPVFANFTQLLTISPLVVAEGGTAWLEWRHVQPTLDLMEAELRKSQVLFSVTRGARHGE 480
LPPVFANFTQLLTISPLVVAEGGTAWLEWRHVQPTLDLMEAELRKSQVLFSVTRGARHGE
Sbjct: 421 LPPVFANFTQLLTISPLVVAEGGTAWLEWRHVQPTLDLMEAELRKSQVLFSVTRGARHGE 480
Query: 481 LELDIPGAQARKMFTLLDVVNRKARFIHDGSEDTSDQLVLEVSVTARVPMPSCLRRGQTY 540
LELDIPGAQARKMFTLLDVVNRKARFIHDGSEDTSDQLVLEVSVTARVPMPSCLRRGQTY
Sbjct: 481 LELDIPGAQARKMFTLLDVVNRKARFIHDGSEDTSDQLVLEVSVTARVPMPSCLRRGQTY 540
Query: 541 LLPIQVNPVNDPPHIIFPHGSLMVILEHTQKPLGPEVFQAYDPDSACEGLTFQVLGTSSG 600
LLPIQVNPVNDPPHIIFPHGSLMVILEHTQKPLGPEVFQAYDPDSACEGLTFQVLGTSSG
Sbjct: 541 LLPIQVNPVNDPPHIIFPHGSLMVILEHTQKPLGPEVFQAYDPDSACEGLTFQVLGTSSG 600
Query: 601 LPVERRDQPGEPATEFSCRELEAGSLVYVHRGGPAQDLTFRVSDGLQASPPATLKVVAIR 660
LPVERRDQPGEPATEFSCRELEAGSLVYVHRGGPAQDLTFRVSDGLQASPPATLKVVAIR
Sbjct: 601 LPVERRDQPGEPATEFSCRELEAGSLVYVHRGGPAQDLTFRVSDGLQASPPATLKVVAIR 660
Query: 661 PAIQIHRSTGLRLAQGSAMPILPANLSVETNAVGQDVSVLFRVTGALQFGELQKQGAGGV 720
PAIQIHRSTGLRLAQGSAMPILPANLSVETNAVGQDVSVLFRVTGALQFGELQKQGAGGV
Sbjct: 661 PAIQIHRSTGLRLAQGSAMPILPANLSVETNAVGQDVSVLFRVTGALQFGELQKQGAGGV 720
Query: 721 EGAEWWATQAFHQRDVEQGRVRYLSTDPQHHAYDTVENLALEVQVGQEILSNLSFPVTIQ 780
EGAEWWATQAFHQRDVEQGRVRYLSTDPQHHAYDTVENLALEVQVGQEILSNLSFPVTIQ
Sbjct: 721 EGAEWWATQAFHQRDVEQGRVRYLSTDPQHHAYDTVENLALEVQVGQEILSNLSFPVTIQ 780
Query: 781 RATVWMLRLEPLHTQNTQQETLTTAHLEATLEEAGPSPPTFHYEVVQAPRKGNLQLQGTR 840
RATVWMLRLEPLHTQNTQQETLTTAHLEATLEEAGPSPPTFHYEVVQAPRKGNLQLQGTR
Sbjct: 781 RATVWMLRLEPLHTQNTQQETLTTAHLEATLEEAGPSPPTFHYEVVQAPRKGNLQLQGTR 840
Query: 841 LSDGQGFTQDDIQAGRVTYGATARASEAVEDTFRFRVTAPPYFSPLYTFPIHIGGDPDAP 900
LSDGQGFTQDDIQAGRVTYGATARASEAVEDTFRFRVTAPPYFSPLYTFPIHIGGDPDAP
Sbjct: 841 LSDGQGFTQDDIQAGRVTYGATARASEAVEDTFRFRVTAPPYFSPLYTFPIHIGGDPDAP 900
Query: 901 VLTNVLLVVPEGGEGVLSADHLFVKSLNSASYLYEVMERPRHGRLAWRGTQDKTTMVTSF 960
VLTNVLLVVPEGGEGVLSADHLFVKSLNSASYLYEVMERPRHGRLAWRGTQDKTTMVTSF
Sbjct: 901 VLTNVLLVVPEGGEGVLSADHLFVKSLNSASYLYEVMERPRHGRLAWRGTQDKTTMVTSF 960
Query: 961 TNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGVFRVAIQPVNDHAPV 1020
TNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGVFRVAIQPVNDHAPV
Sbjct: 961 TNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGVFRVAIQPVNDHAPV 1020
Query: 1021 QTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIVAVDEPTRPIYR 1080
QTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIVAVDEPTRPIYR
Sbjct: 1021 QTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIVAVDEPTRPIYR 1080
Query: 1081 FTQEDLRKRRVLFVHSGADRGWIQLQVSDGQHQATALLEVQASEPYLRVANGSSLVVPQG 1140
FTQEDLRKRRVLFVHSGADRGWIQLQVSDGQHQATALLEVQASEPYLRVANGSSLVVPQG
Sbjct: 1081 FTQEDLRKRRVLFVHSGADRGWIQLQVSDGQHQATALLEVQASEPYLRVANGSSLVVPQG 1140
Query: 1141 GQGTIDTAVLHLDTNLDIRSGDEVHYHVTAGPRWGQLVRAGQPATAFSQQDLLDGAVLYS 1200
GQGTIDTAVLHLDTNLDIRSGDEVHYHVTAGPRWGQLVRAGQPATAFSQQDLLDGAVLYS
Sbjct: 1141 GQGTIDTAVLHLDTNLDIRSGDEVHYHVTAGPRWGQLVRAGQPATAFSQQDLLDGAVLYS 1200
Query: 1201 HNGSLSPRDTMAFSVEAGPVHTDATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEIRRD 1260
HNGSLSPRDTMAFSVEAGPVHTDATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEIRRD
Sbjct: 1201 HNGSLSPRDTMAFSVEAGPVHTDATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEIRRD 1260
Query: 1261 QLEAAQEAVPPADIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLY 1320
QLEAAQEAVPPADIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLY
Sbjct: 1261 QLEAAQEAVPPADIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLY 1320
Query: 1321 LHSRPEAWSDAFSLDVASGLGAPLEGVLVELEVLPAAIPLEAQNFSVPEGGSLTLAPPLL 1380
LHSRPEAWSDAFSLDVASGLGAPLEGVLVELEVLPAAIPLEAQNFSVPEGGSLTLAPPLL
Sbjct: 1321 LHSRPEAWSDAFSLDVASGLGAPLEGVLVELEVLPAAIPLEAQNFSVPEGGSLTLAPPLL 1380
Query: 1381 RVSGPYFPTLLGLSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVHDGSETL 1440
RVSGPYFPTLLGLSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVHDGSETL
Sbjct: 1381 RVSGPYFPTLLGLSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVHDGSETL 1440
Query: 1441 TDSFVLMANASEMDRQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEALRST 1500
TDSFVLMANASEMDRQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEALRST
Sbjct: 1441 TDSFVLMANASEMDRQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEALRST 1500
Query: 1501 DGDSGSEDLVYTIEQPSNGRVVLRGAPGTEVRSFTQAQLDGGLVLFSHRGTLDGGFRFRL 1560
DGDSGSEDLVYTIEQPSNGRVVLRGAPGTEVRSFTQAQLDGGLVLFSHRGTLDGGFRFRL
Sbjct: 1501 DGDSGSEDLVYTIEQPSNGRVVLRGAPGTEVRSFTQAQLDGGLVLFSHRGTLDGGFRFRL 1560
Query: 1561 SDGEHTSPGHFFRVTAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASSSAGTDPQLLLY 1620
SDGEHTSPGHFFRVTAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASSSAGTDPQLLLY
Sbjct: 1561 SDGEHTSPGHFFRVTAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASSSAGTDPQLLLY 1620
Query: 1621 RVVRGPQLGRLFHAQQDSTGEALVNFTQAEVYAGNILYEHEMPPEPFWEAHDTLELQLSS 1680
RVVRGPQLGRLFHAQQDSTGEALVNFTQAEVYAGNILYEHEMPPEPFWEAHDTLELQLSS
Sbjct: 1621 RVVRGPQLGRLFHAQQDSTGEALVNFTQAEVYAGNILYEHEMPPEPFWEAHDTLELQLSS 1680
Query: 1681 PPARDVAATLAVAVSFEAACPQRPSHLWKNKGLWVPEGQRARITVAALDASNLLASVPSP 1740
PPARDVAATLAVAVSFEAACPQRPSHLWKNKGLWVPEGQRARITVAALDASNLLASVPSP
Sbjct: 1681 PPARDVAATLAVAVSFEAACPQRPSHLWKNKGLWVPEGQRARITVAALDASNLLASVPSP 1740
Query: 1741 QRSEHDVLFQVTQFPSRGQLLVSEEPLHAGQPHFLQSQLAAGQLVYAHGGGGTQQDGFHF 1800
QRSEHDVLFQVTQFPSRGQLLVSEEPLHAGQPHFLQSQLAAGQLVYAHGGGGTQQDGFHF
Sbjct: 1741 QRSEHDVLFQVTQFPSRGQLLVSEEPLHAGQPHFLQSQLAAGQLVYAHGGGGTQQDGFHF 1800
Query: 1801 RAHLQGPAGASVAGPQTSEAFAITVRDVNERPPQPQASVPLRLTRGSRAPISRAQLSVVD 1860
RAHLQGPAGASVAGPQTSEAFAITVRDVNERPPQPQASVPLRLTRGSRAPISRAQLSVVD
Sbjct: 1801 RAHLQGPAGASVAGPQTSEAFAITVRDVNERPPQPQASVPLRLTRGSRAPISRAQLSVVD 1860
Query: 1861 PDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQADVDSGRLAFVANGSSVAGIFQLS 1920
PDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQADVDSGRLAFVANGSSVAGIFQLS
Sbjct: 1861 PDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQADVDSGRLAFVANGSSVAGIFQLS 1920
Query: 1921 MSDGASPPLPMSLAVDILPSAIEVQLRAPLEVPQALGRSSLSQQQLRVVSDREEPEAAYR 1980
MSDGASPPLPMSLAVDILPSAIEVQLRAPLEVPQALGRSSLSQQQLRVVSDREEPEAAYR
Sbjct: 1921 MSDGASPPLPMSLAVDILPSAIEVQLRAPLEVPQALGRSSLSQQQLRVVSDREEPEAAYR 1980
Query: 1981 LIQGPQYGHLLVGGRPTSAFSQFQIDQGEVVFAFTNFSSSHDHFRVLALARGVNASAVVN 2040
LIQGPQYGHLLVGGRPTSAFSQFQIDQGEVVFAFTNFSSSHDHFRVLALARGVNASAVVN
Sbjct: 1981 LIQGPQYGHLLVGGRPTSAFSQFQIDQGEVVFAFTNFSSSHDHFRVLALARGVNASAVVN 2040
Query: 2041 VTVRALLHVWAGGPWPQGATLRLDPTVLDAGELANRTGSVPRFRLLEGPRHGRVVRVPRA 2100
VTVRALLHVWAGGPWPQGATLRLDPTVLDAGELANRTGSVPRFRLLEGPRHGRVVRVPRA
Sbjct: 2041 VTVRALLHVWAGGPWPQGATLRLDPTVLDAGELANRTGSVPRFRLLEGPRHGRVVRVPRA 2100
Query: 2101 RTEPGGSQLVEQFTQQDLEDGRLGLEVGRPEGRAPGPAGDSLTLELWAQGVPPAVASLDF 2160
RTEPGGSQLVEQFTQQDLEDGRLGLEVGRPEGRAPGPAGDSLTLELWAQGVPPAVASLDF
Sbjct: 2101 RTEPGGSQLVEQFTQQDLEDGRLGLEVGRPEGRAPGPAGDSLTLELWAQGVPPAVASLDF 2160
Query: 2161 ATEPYNAARPYSVALLSVPEAARTEAGKPESSTPTGEPGPMASSPEPAVAKGGFLSFLEA 2220
ATEPYNAARPYSVALLSVPEAARTEAGKPESSTPTGEPGPMASSPEPAVAKGGFLSFLEA
Sbjct: 2161 ATEPYNAARPYSVALLSVPEAARTEAGKPESSTPTGEPGPMASSPEPAVAKGGFLSFLEA 2220
Query: 2221 NMFSVIIPMCLVLLLLALILPLLFYLRKRNKTGKHDVQVLTAKPRNGLAGDTETFRKVEP 2280
NMFSVIIPMCLVLLLLALILPLLFYLRKRNKTGKHDVQVLTAKPRNGLAGDTETFRKVEP
Sbjct: 2221 NMFSVIIPMCLVLLLLALILPLLFYLRKRNKTGKHDVQVLTAKPRNGLAGDTETFRKVEP 2280
Query: 2281 GQAIPLTAVPGQGPPPGGQPDPELLQFCRTPNPALKNGQYWV 2322
GQAIPLTAVPGQGPPPGGQPDPELLQFCRTPNPALKNGQYWV
Sbjct: 2281 GQAIPLTAVPGQGPPPGGQPDPELLQFCRTPNPALKNGQYWV 2322
>gi|239756382 PREDICTED: similar to KIAA1920 protein [Homo sapiens]
Length = 483
Score = 780 bits (2014), Expect = 0.0
Identities = 398/480 (82%), Positives = 415/480 (86%), Gaps = 5/480 (1%)
Query: 492 KMFTLLDVVNRKARFIHDGSEDTSDQLVLEVSVTARVPMPSCLRRGQTYLLPIQVNPVND 551
K LDVVN KA FIHDG EDTSDQLVLEVSV A VPMPSCL RGQT LLPIQVNPVND
Sbjct: 9 KCSPFLDVVNCKACFIHDGPEDTSDQLVLEVSVMAWVPMPSCLWRGQTDLLPIQVNPVND 68
Query: 552 PPHIIFPHGSLMVILEHTQKPLGPEVFQAYDPDSACEGLTFQVLGTSSGLPVERRDQPGE 611
PPHIIFPHGSLMVILEHT KPLGPEV QAYD DS CEGL FQ+LGT SGLPVE RDQPGE
Sbjct: 69 PPHIIFPHGSLMVILEHTHKPLGPEVLQAYDLDSTCEGLAFQLLGTPSGLPVEHRDQPGE 128
Query: 612 PATEFSCRELEAGSLVYVHRGGPAQDLTFRVSDGLQASPPATLKVVAIRPAIQIHRSTGL 671
P TEFSC ELEAGSLVYVH GGP QDLTFRVS+GLQASPPA LKVVA++ AIQIHRSTGL
Sbjct: 129 PVTEFSCWELEAGSLVYVHCGGPTQDLTFRVSNGLQASPPAMLKVVAVQLAIQIHRSTGL 188
Query: 672 RLAQGSAMPILPANLSVETNAVGQDVSVLFRVTGALQFGELQKQGAGGVEGAEWWATQAF 731
LAQGSAMPILP NL VET+AVGQDV+VL RVTG L F ELQKQGAGGVE AEWW TQAF
Sbjct: 189 HLAQGSAMPILPTNLLVETSAVGQDVTVLLRVTGGLPFRELQKQGAGGVEDAEWWVTQAF 248
Query: 732 HQRDVEQGRVRYLSTDPQHHAYDTVENLALEVQVGQEILSNLSFPVTIQRATVWMLRLEP 791
HQ+DV+QG VRYLSTDPQH+ DTVENL L+VQV EILSNLSF VTIQRATVWML+LEP
Sbjct: 249 HQQDVDQGHVRYLSTDPQHYTEDTVENLDLQVQVSWEILSNLSFLVTIQRATVWMLQLEP 308
Query: 792 LHTQNTQQETLTTAHLEATLEEAGPSPPTFHYEVVQAPRKGNLQLQGTRLSDGQGFTQDD 851
LHTQNTQQE LTTAHLEATLEEAGPSPPTFH EVVQAPRKGN QLQGT +SDGQGFTQDD
Sbjct: 309 LHTQNTQQEALTTAHLEATLEEAGPSPPTFHCEVVQAPRKGNFQLQGTMMSDGQGFTQDD 368
Query: 852 IQAGRVTYGATARASEAVEDTFRFRVTAPPYFSPLYTFPIHIGGDPDAPVLTNVLLVVPE 911
+QA VTYGA ARAS AVEDTF F VTAPPYFSPL TF IHIGGDPD PV LVVPE
Sbjct: 369 VQAAEVTYGAMARASVAVEDTFCFHVTAPPYFSPLCTFSIHIGGDPDMPV-----LVVPE 423
Query: 912 GGEGVLSADHLFVKSLNSASYLYEVMERPRHGRLAWRGTQDKTTMVTSFTNEDLLRGRLV 971
GGE VLSAD LF+KSLNSA YLYEVME+PRHGRL WRGTQDK TMVTSFTN DL+ G+LV
Sbjct: 424 GGECVLSADQLFIKSLNSARYLYEVMEQPRHGRLTWRGTQDKITMVTSFTNGDLMHGQLV 483
Score = 90.1 bits (222), Expect = 2e-17
Identities = 123/490 (25%), Positives = 196/490 (40%), Gaps = 47/490 (9%)
Query: 1432 YVHDGSETLTDSFVLMANASEMDR------QSHPVAFTVTVLPVNDQPPILTTNTGLQM- 1484
++HDG E +D VL + + + V PVND P I+ + L +
Sbjct: 23 FIHDGPEDTSDQLVLEVSVMAWVPMPSCLWRGQTDLLPIQVNPVNDPPHIIFPHGSLMVI 82
Query: 1485 WEGATAPIPAEALRSTDGDSGSEDLVYTI-EQPSNGRVVLRGAPGTEVRSFTQAQLDGGL 1543
E P+ E L++ D DS E L + + PS V R PG V F+ +L+ G
Sbjct: 83 LEHTHKPLGPEVLQAYDLDSTCEGLAFQLLGTPSGLPVEHRDQPGEPVTEFSCWELEAGS 142
Query: 1544 VLFSHRGTLDGGFRFRLSDGEHTSPGHFFRVTAQKQVLLSLKGSQTLTVCPGSVQPLSSQ 1603
+++ H G FR+S+G SP +V A Q+ + + S L + GS P+
Sbjct: 143 LVYVHCGGPTQDLTFRVSNGLQASPPAMLKVVA-VQLAIQIHRSTGLHLAQGSAMPILPT 201
Query: 1604 TLRASSSAGTDPQLLLYRVVRGPQLGRL----FHAQQDSTGEALVNFTQAEVYAGNILYE 1659
L +SA +L RV G L +D+ F Q +V G++ Y
Sbjct: 202 NLLVETSAVGQDVTVLLRVTGGLPFRELQKQGAGGVEDAEWWVTQAFHQQDVDQGHVRY- 260
Query: 1660 HEMPPEPFWEAHDTLE-LQLSSPPARDVAATLAVAVSFEAACPQRPSHLW--KNKGLWVP 1716
+ +P DT+E L L + ++ + L+ V+ + A +W + + L
Sbjct: 261 --LSTDPQHYTEDTVENLDLQVQVSWEILSNLSFLVTIQRAT------VWMLQLEPLHTQ 312
Query: 1717 EGQRARITVAALDASNLLASVPSPQRSEHDVLFQVTQFPSRGQLLVSEEPLHAGQPHFLQ 1776
Q+ +T A L+A+ L + PSP +V Q P +G + + GQ F Q
Sbjct: 313 NTQQEALTTAHLEAT-LEEAGPSPPTFH----CEVVQAPRKGNFQLQGTMMSDGQ-GFTQ 366
Query: 1777 SQLAAGQLVYAHGGGGTQQDGFHFRAHLQGPAGASVAGPQTSEAFAITVRDVNERPPQPQ 1836
+ A ++ Y + F H+ P P S ++ + P P
Sbjct: 367 DDVQAAEVTYGAMARASVAVEDTFCFHVTAP-------PYFSPLCTFSIH-IGGDPDMPV 418
Query: 1837 ASVPLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVG--GGLGPVTRF 1894
VP G +S QL + +SA YEV P +G L+ G + VT F
Sbjct: 419 LVVP----EGGECVLSADQLFIKSLNSA--RYLYEVMEQPRHGRLTWRGTQDKITMVTSF 472
Query: 1895 TQADVDSGRL 1904
T D+ G+L
Sbjct: 473 TNGDLMHGQL 482
Score = 64.7 bits (156), Expect = 1e-09
Identities = 108/465 (23%), Positives = 178/465 (38%), Gaps = 44/465 (9%)
Query: 964 DLLRGRLVYQHDDSETTEDDIPF-VATRQGESSGDMAWEEVRGVFRVAIQPVND------ 1016
D++ + + HD E T D + V+ W + + + PVND
Sbjct: 15 DVVNCKACFIHDGPEDTSDQLVLEVSVMAWVPMPSCLWRGQTDLLPIQVNPVNDPPHIIF 74
Query: 1017 -HAPVQTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIVAVDEPT 1075
H + I H G L D G A QL+ T L + D+P
Sbjct: 75 PHGSLMVILEHTHKPLGPEVLQAYD---LDSTCEGLA-FQLLGTPSGL---PVEHRDQPG 127
Query: 1076 RPIYRFTQEDLRKRRVLFVHSGADRGWIQLQVSDG-QHQATALLEVQASEPYLRVANGSS 1134
P+ F+ +L +++VH G + +VS+G Q A+L+V A + +++ +
Sbjct: 128 EPVTEFSCWELEAGSLVYVHCGGPTQDLTFRVSNGLQASPPAMLKVVAVQLAIQIHRSTG 187
Query: 1135 LVVPQGGQGTIDTAVLHLDTNLDIRSGDEVHYHVTAGPRWGQLVRAGQPAT--------- 1185
L + QG I L ++T+ + V VT G + +L + G
Sbjct: 188 LHLAQGSAMPILPTNLLVETSA-VGQDVTVLLRVTGGLPFRELQKQGAGGVEDAEWWVTQ 246
Query: 1186 AFSQQDLLDGAVLYSHNGSLSPRDTMAFSVEAGPVHTDATLQVTIALEGPLAPLKLVRHK 1245
AF QQD+ G V Y S P+ +VE + D +QV+ + L+ L ++
Sbjct: 247 AFHQQDVDQGHVRYL---STDPQHYTEDTVE----NLDLQVQVSWEILSNLSFLVTIQRA 299
Query: 1246 KIYVFQGEAAEIRRDQLEAAQEAVPPADIVFSVKSPPSAGYLVMVS--RGALADEPPSLD 1303
+++ Q E + Q EA A A + + SPP+ V+ + +G + +
Sbjct: 300 TVWMLQLEPLHTQNTQQEALTTAHLEATLEEAGPSPPTFHCEVVQAPRKGNFQLQGTMMS 359
Query: 1304 PVQSFSQEAVDTGRVLY--LHSRPEAWSDAFSLDVASGLGAPLEGVLVELEVLPAAIPLE 1361
Q F+Q+ V V Y + A D F V + P L + P +
Sbjct: 360 DGQGFTQDDVQAAEVTYGAMARASVAVEDTFCFHVTA---PPYFSPLCTFSIHIGGDP-D 415
Query: 1362 AQNFSVPEGGSLTLAPPLLRVSGPYFPTLLGLSLQVLEPPQHGAL 1406
VPEGG L+ L + L +V+E P+HG L
Sbjct: 416 MPVLVVPEGGECVLSADQLFIKSLNSARYL---YEVMEQPRHGRL 457
Score = 38.1 bits (87), Expect = 0.10
Identities = 92/402 (22%), Positives = 142/402 (35%), Gaps = 55/402 (13%)
Query: 1749 FQVTQFPSRGQLLVSEEPLHAGQP--HFLQSQLAAGQLVYAHGGGGTQQDGFHFRAHLQG 1806
FQ+ PS + ++P G+P F +L AG LVY H GG TQ F LQ
Sbjct: 109 FQLLGTPSGLPVEHRDQP---GEPVTEFSCWELEAGSLVYVHCGGPTQDLTFRVSNGLQA 165
Query: 1807 --PAGASVAGPQTSEAFAITVRDVNERPPQPQASVPLRLTRGSRAPISRAQLSVVDPDSA 1864
PA V Q + Q S L L +GS PI L +V+ +
Sbjct: 166 SPPAMLKVVAVQLAI--------------QIHRSTGLHLAQGSAMPILPTNL-LVETSAV 210
Query: 1865 PGEIEYEVQRAPHNGFLSLVGGGLGPVT--------RFTQADVDSGRLAFVANG-----S 1911
++ ++ F L G G V F Q DVD G + +++
Sbjct: 211 GQDVTVLLRVTGGLPFRELQKQGAGGVEDAEWWVTQAFHQQDVDQGHVRYLSTDPQHYTE 270
Query: 1912 SVAGIFQLSMSDGASPPLPMSLAVDILPSAIEVQLRAPLEVPQALGRSSLSQQQLRVVSD 1971
L + +S V I + + + PL Q + +L+ L +
Sbjct: 271 DTVENLDLQVQVSWEILSNLSFLVTIQRATVWMLQLEPLHT-QNTQQEALTTAHLEATLE 329
Query: 1972 REEPEAAY---RLIQGPQYGHLLVGGRPTS---AFSQFQIDQGEVVFAFTNFSSS--HDH 2023
P ++Q P+ G+ + G S F+Q + EV + +S D
Sbjct: 330 EAGPSPPTFHCEVVQAPRKGNFQLQGTMMSDGQGFTQDDVQAAEVTYGAMARASVAVEDT 389
Query: 2024 FRVLALARGVNASAVVNVTVRALLHVWAGGPWPQGATLRLDPTVLDAGELANRTGSVPRF 2083
F V A + +H+ P VL A +L ++ + R+
Sbjct: 390 F-----CFHVTAPPYFSPLCTFSIHIGGDPDMPVLVVPEGGECVLSADQLFIKSLNSARY 444
Query: 2084 --RLLEGPRHGRVVRVPRARTEPGGSQLVEQFTQQDLEDGRL 2123
++E PRHGR+ R +V FT DL G+L
Sbjct: 445 LYEVMEQPRHGRLT----WRGTQDKITMVTSFTNGDLMHGQL 482
Score = 33.5 bits (75), Expect = 2.5
Identities = 77/375 (20%), Positives = 139/375 (37%), Gaps = 39/375 (10%)
Query: 1303 DPVQSFSQEAVDTGRVLYLHSRPEAWSDAFSLDVASGLGAPLEGVLVELEVLPAAIPLEA 1362
+PV FS ++ G ++Y+H F V++GL A +L + V A +
Sbjct: 128 EPVTEFSCWELEAGSLVYVHCGGPTQDLTFR--VSNGLQASPPAMLKVVAVQLAIQIHRS 185
Query: 1363 QNFSVPEGGSLTLAPPLLRVS----GPYFPTLLGLS--LQVLEPPQHGALQKEDGPQART 1416
+ +G ++ + P L V G LL ++ L E + GA ED T
Sbjct: 186 TGLHLAQGSAMPILPTNLLVETSAVGQDVTVLLRVTGGLPFRELQKQGAGGVEDAEWWVT 245
Query: 1417 LSAFSWRMVEEQLIRYVHDGSETLTDSFV------LMANASEMDRQSHPVAFTVTVLPVN 1470
AF + V++ +RY+ + T+ V + + + S V + +
Sbjct: 246 -QAFHQQDVDQGHVRYLSTDPQHYTEDTVENLDLQVQVSWEILSNLSFLVTIQRATVWML 304
Query: 1471 DQPPILTTNTGLQMWEGATAPIPAEALRSTDGDSGSEDLVYTIEQPSNGRVVLRGAPGTE 1530
P+ T NT + A EA G S ++ P G L+G ++
Sbjct: 305 QLEPLHTQNTQQE----ALTTAHLEATLEEAGPSPPTFHCEVVQAPRKGNFQLQGTMMSD 360
Query: 1531 VRSFTQAQLDGGLVLFSHRG----TLDGGFRFRLSDGEHTSPGHFFRV----TAQKQVLL 1582
+ FTQ + V + ++ F F ++ + SP F + VL+
Sbjct: 361 GQGFTQDDVQAAEVTYGAMARASVAVEDTFCFHVTAPPYFSPLCTFSIHIGGDPDMPVLV 420
Query: 1583 SLKGSQTLTVCPGSVQPLSSQTLRASSSAGTDPQLLLYRVVRGPQLGRLFHAQQDSTGEA 1642
+G + C S L ++L ++ LY V+ P+ GRL
Sbjct: 421 VPEGGE----CVLSADQLFIKSLNSAR--------YLYEVMEQPRHGRLTWRGTQDKITM 468
Query: 1643 LVNFTQAEVYAGNIL 1657
+ +FT ++ G ++
Sbjct: 469 VTSFTNGDLMHGQLV 483
>gi|239757979 PREDICTED: similar to chondroitin sulfate proteoglycan
4 [Homo sapiens]
Length = 296
Score = 471 bits (1211), Expect = e-132
Identities = 244/294 (82%), Positives = 257/294 (87%)
Query: 45 ALTDIDLQLQFSTSQPEALLLLAAGPADHLLLQLYSGRLQVRLVLGQEELRLQTPAETLL 104
ALTDIDLQLQFSTSQPEALLLLAAGPADHLLLQLYSG LQVR+VLGQEELRLQ PAE LL
Sbjct: 2 ALTDIDLQLQFSTSQPEALLLLAAGPADHLLLQLYSGHLQVRVVLGQEELRLQIPAEMLL 61
Query: 105 SDSIPHTVVLTVVEGWATLSVDGFLNASSAVPGAPLEVPYGLFVGGTGTLGLPYLRGTSR 164
SDSIP+T VLTV EGW TLSV+GFLNASS V GAPLEVPYGLFVG TG+LGLPYLRGTS
Sbjct: 62 SDSIPYTTVLTVSEGWPTLSVNGFLNASSVVLGAPLEVPYGLFVGNTGSLGLPYLRGTSH 121
Query: 165 PLRGCLHAATLNGRSLLRPLTPDVHEGCAEEFSASDDVALGFSGPHSLAAFPAWGTQDEG 224
PLRGCLHAATLNG SLLRPLTPD+HEGCAEEFS SDDVALGFSGPHSLAAFPAWGTQ++G
Sbjct: 122 PLRGCLHAATLNGHSLLRPLTPDMHEGCAEEFSTSDDVALGFSGPHSLAAFPAWGTQNKG 181
Query: 225 TLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLHNSVPVADGQP 284
TLE LTTQ QAPL FQA G GDFI+VDIFEGHL +VEKGQGTVLL NSV VAD Q
Sbjct: 182 TLELALTTQIWQAPLTFQAAGWHGDFIHVDIFEGHLWFMVEKGQGTVLLLNSVLVADVQT 241
Query: 285 HEVSVHINAHRLEISVDQYPTHTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEH 338
+VS+HIN H+LEIS+DQYPT T NRGVLS LEP SLLLG L AEAS LQEH
Sbjct: 242 LKVSIHINTHQLEISMDQYPTRTLNRGVLSCLEPCDSLLLGELVAEASHPLQEH 295
Score = 34.3 bits (77), Expect = 1.5
Identities = 45/183 (24%), Positives = 78/183 (42%), Gaps = 17/183 (9%)
Query: 226 LEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLH--NSVPVADGQ 283
L+ +T +A L AG D + + ++ GHL+ V GQ + L + ++D
Sbjct: 8 LQLQFSTSQPEALLLLAAGP--ADHLLLQLYSGHLQVRVVLGQEELRLQIPAEMLLSDSI 65
Query: 284 PHEVSVHINAHRLEISVDQYPTHTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLT 343
P+ + ++ +SV+ + + S+ + + LE L +G + +L+
Sbjct: 66 PYTTVLTVSEGWPTLSVNGF-LNASSVVLGAPLEVPYGLFVGNTGSLGLPYLR------- 117
Query: 344 PEATNASLLGCMEDLSVNGQRRGLREALLTRNMAAGCRLEEEEYEDDAYGHYEAFSTLAP 403
T+ L GC+ ++NG LR LT +M GC E +D A G S A
Sbjct: 118 --GTSHPLRGCLHAATLNGHSL-LRP--LTPDMHEGCAEEFSTSDDVALGFSGPHSLAAF 172
Query: 404 EAW 406
AW
Sbjct: 173 PAW 175
>gi|169217335 PREDICTED: similar to chondroitin sulfate proteoglycan
4 [Homo sapiens]
Length = 296
Score = 471 bits (1211), Expect = e-132
Identities = 244/294 (82%), Positives = 257/294 (87%)
Query: 45 ALTDIDLQLQFSTSQPEALLLLAAGPADHLLLQLYSGRLQVRLVLGQEELRLQTPAETLL 104
ALTDIDLQLQFSTSQPEALLLLAAGPADHLLLQLYSG LQVR+VLGQEELRLQ PAE LL
Sbjct: 2 ALTDIDLQLQFSTSQPEALLLLAAGPADHLLLQLYSGHLQVRVVLGQEELRLQIPAEMLL 61
Query: 105 SDSIPHTVVLTVVEGWATLSVDGFLNASSAVPGAPLEVPYGLFVGGTGTLGLPYLRGTSR 164
SDSIP+T VLTV EGW TLSV+GFLNASS V GAPLEVPYGLFVG TG+LGLPYLRGTS
Sbjct: 62 SDSIPYTTVLTVSEGWPTLSVNGFLNASSVVLGAPLEVPYGLFVGNTGSLGLPYLRGTSH 121
Query: 165 PLRGCLHAATLNGRSLLRPLTPDVHEGCAEEFSASDDVALGFSGPHSLAAFPAWGTQDEG 224
PLRGCLHAATLNG SLLRPLTPD+HEGCAEEFS SDDVALGFSGPHSLAAFPAWGTQ++G
Sbjct: 122 PLRGCLHAATLNGHSLLRPLTPDMHEGCAEEFSTSDDVALGFSGPHSLAAFPAWGTQNKG 181
Query: 225 TLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLHNSVPVADGQP 284
TLE LTTQ QAPL FQA G GDFI+VDIFEGHL +VEKGQGTVLL NSV VAD Q
Sbjct: 182 TLELALTTQIWQAPLTFQAAGWHGDFIHVDIFEGHLWFMVEKGQGTVLLLNSVLVADVQT 241
Query: 285 HEVSVHINAHRLEISVDQYPTHTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEH 338
+VS+HIN H+LEIS+DQYPT T NRGVLS LEP SLLLG L AEAS LQEH
Sbjct: 242 LKVSIHINTHQLEISMDQYPTRTLNRGVLSCLEPCDSLLLGELVAEASHPLQEH 295
Score = 34.3 bits (77), Expect = 1.5
Identities = 45/183 (24%), Positives = 78/183 (42%), Gaps = 17/183 (9%)
Query: 226 LEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLH--NSVPVADGQ 283
L+ +T +A L AG D + + ++ GHL+ V GQ + L + ++D
Sbjct: 8 LQLQFSTSQPEALLLLAAGP--ADHLLLQLYSGHLQVRVVLGQEELRLQIPAEMLLSDSI 65
Query: 284 PHEVSVHINAHRLEISVDQYPTHTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLT 343
P+ + ++ +SV+ + + S+ + + LE L +G + +L+
Sbjct: 66 PYTTVLTVSEGWPTLSVNGF-LNASSVVLGAPLEVPYGLFVGNTGSLGLPYLR------- 117
Query: 344 PEATNASLLGCMEDLSVNGQRRGLREALLTRNMAAGCRLEEEEYEDDAYGHYEAFSTLAP 403
T+ L GC+ ++NG LR LT +M GC E +D A G S A
Sbjct: 118 --GTSHPLRGCLHAATLNGHSL-LRP--LTPDMHEGCAEEFSTSDDVALGFSGPHSLAAF 172
Query: 404 EAW 406
AW
Sbjct: 173 PAW 175
>gi|239747036 PREDICTED: hypothetical protein XP_002344245 [Homo
sapiens]
Length = 296
Score = 471 bits (1211), Expect = e-132
Identities = 244/294 (82%), Positives = 257/294 (87%)
Query: 45 ALTDIDLQLQFSTSQPEALLLLAAGPADHLLLQLYSGRLQVRLVLGQEELRLQTPAETLL 104
ALTDIDLQLQFSTSQPEALLLLAAGPADHLLLQLYSG LQVR+VLGQEELRLQ PAE LL
Sbjct: 2 ALTDIDLQLQFSTSQPEALLLLAAGPADHLLLQLYSGHLQVRVVLGQEELRLQIPAEMLL 61
Query: 105 SDSIPHTVVLTVVEGWATLSVDGFLNASSAVPGAPLEVPYGLFVGGTGTLGLPYLRGTSR 164
SDSIP+T VLTV EGW TLSV+GFLNASS V GAPLEVPYGLFVG TG+LGLPYLRGTS
Sbjct: 62 SDSIPYTTVLTVSEGWPTLSVNGFLNASSVVLGAPLEVPYGLFVGNTGSLGLPYLRGTSH 121
Query: 165 PLRGCLHAATLNGRSLLRPLTPDVHEGCAEEFSASDDVALGFSGPHSLAAFPAWGTQDEG 224
PLRGCLHAATLNG SLLRPLTPD+HEGCAEEFS SDDVALGFSGPHSLAAFPAWGTQ++G
Sbjct: 122 PLRGCLHAATLNGHSLLRPLTPDMHEGCAEEFSTSDDVALGFSGPHSLAAFPAWGTQNKG 181
Query: 225 TLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLHNSVPVADGQP 284
TLE LTTQ QAPL FQA G GDFI+VDIFEGHL +VEKGQGTVLL NSV VAD Q
Sbjct: 182 TLELALTTQIWQAPLTFQAAGWHGDFIHVDIFEGHLWFMVEKGQGTVLLLNSVLVADVQT 241
Query: 285 HEVSVHINAHRLEISVDQYPTHTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEH 338
+VS+HIN H+LEIS+DQYPT T NRGVLS LEP SLLLG L AEAS LQEH
Sbjct: 242 LKVSIHINTHQLEISMDQYPTRTLNRGVLSCLEPCDSLLLGELVAEASHPLQEH 295
Score = 34.3 bits (77), Expect = 1.5
Identities = 45/183 (24%), Positives = 78/183 (42%), Gaps = 17/183 (9%)
Query: 226 LEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLH--NSVPVADGQ 283
L+ +T +A L AG D + + ++ GHL+ V GQ + L + ++D
Sbjct: 8 LQLQFSTSQPEALLLLAAGP--ADHLLLQLYSGHLQVRVVLGQEELRLQIPAEMLLSDSI 65
Query: 284 PHEVSVHINAHRLEISVDQYPTHTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLT 343
P+ + ++ +SV+ + + S+ + + LE L +G + +L+
Sbjct: 66 PYTTVLTVSEGWPTLSVNGF-LNASSVVLGAPLEVPYGLFVGNTGSLGLPYLR------- 117
Query: 344 PEATNASLLGCMEDLSVNGQRRGLREALLTRNMAAGCRLEEEEYEDDAYGHYEAFSTLAP 403
T+ L GC+ ++NG LR LT +M GC E +D A G S A
Sbjct: 118 --GTSHPLRGCLHAATLNGHSL-LRP--LTPDMHEGCAEEFSTSDDVALGFSGPHSLAAF 172
Query: 404 EAW 406
AW
Sbjct: 173 PAW 175
>gi|239747031 PREDICTED: hypothetical protein XP_002344244 [Homo
sapiens]
Length = 296
Score = 471 bits (1211), Expect = e-132
Identities = 244/294 (82%), Positives = 257/294 (87%)
Query: 45 ALTDIDLQLQFSTSQPEALLLLAAGPADHLLLQLYSGRLQVRLVLGQEELRLQTPAETLL 104
ALTDIDLQLQFSTSQPEALLLLAAGPADHLLLQLYSG LQVR+VLGQEELRLQ PAE LL
Sbjct: 2 ALTDIDLQLQFSTSQPEALLLLAAGPADHLLLQLYSGHLQVRVVLGQEELRLQIPAEMLL 61
Query: 105 SDSIPHTVVLTVVEGWATLSVDGFLNASSAVPGAPLEVPYGLFVGGTGTLGLPYLRGTSR 164
SDSIP+T VLTV EGW TLSV+GFLNASS V GAPLEVPYGLFVG TG+LGLPYLRGTS
Sbjct: 62 SDSIPYTTVLTVSEGWPTLSVNGFLNASSVVLGAPLEVPYGLFVGNTGSLGLPYLRGTSH 121
Query: 165 PLRGCLHAATLNGRSLLRPLTPDVHEGCAEEFSASDDVALGFSGPHSLAAFPAWGTQDEG 224
PLRGCLHAATLNG SLLRPLTPD+HEGCAEEFS SDDVALGFSGPHSLAAFPAWGTQ++G
Sbjct: 122 PLRGCLHAATLNGHSLLRPLTPDMHEGCAEEFSTSDDVALGFSGPHSLAAFPAWGTQNKG 181
Query: 225 TLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLHNSVPVADGQP 284
TLE LTTQ QAPL FQA G GDFI+VDIFEGHL +VEKGQGTVLL NSV VAD Q
Sbjct: 182 TLELALTTQIWQAPLTFQAAGWHGDFIHVDIFEGHLWFMVEKGQGTVLLLNSVLVADVQT 241
Query: 285 HEVSVHINAHRLEISVDQYPTHTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEH 338
+VS+HIN H+LEIS+DQYPT T NRGVLS LEP SLLLG L AEAS LQEH
Sbjct: 242 LKVSIHINTHQLEISMDQYPTRTLNRGVLSCLEPCDSLLLGELVAEASHPLQEH 295
Score = 34.3 bits (77), Expect = 1.5
Identities = 45/183 (24%), Positives = 78/183 (42%), Gaps = 17/183 (9%)
Query: 226 LEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLH--NSVPVADGQ 283
L+ +T +A L AG D + + ++ GHL+ V GQ + L + ++D
Sbjct: 8 LQLQFSTSQPEALLLLAAGP--ADHLLLQLYSGHLQVRVVLGQEELRLQIPAEMLLSDSI 65
Query: 284 PHEVSVHINAHRLEISVDQYPTHTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLT 343
P+ + ++ +SV+ + + S+ + + LE L +G + +L+
Sbjct: 66 PYTTVLTVSEGWPTLSVNGF-LNASSVVLGAPLEVPYGLFVGNTGSLGLPYLR------- 117
Query: 344 PEATNASLLGCMEDLSVNGQRRGLREALLTRNMAAGCRLEEEEYEDDAYGHYEAFSTLAP 403
T+ L GC+ ++NG LR LT +M GC E +D A G S A
Sbjct: 118 --GTSHPLRGCLHAATLNGHSL-LRP--LTPDMHEGCAEEFSTSDDVALGFSGPHSLAAF 172
Query: 404 EAW 406
AW
Sbjct: 173 PAW 175
>gi|79749430 FRAS1-related extracellular matrix protein 2 precursor
[Homo sapiens]
Length = 3169
Score = 207 bits (527), Expect = 1e-52
Identities = 404/1675 (24%), Positives = 650/1675 (38%), Gaps = 228/1675 (13%)
Query: 410 ELPEPCVPEPGLPPVFANFTQLLTIS---PLVVAE--GGTAWLEWRHVQPTLDLMEAELR 464
+ P V P + V FTQL ++ PLVV E G + L+ R ++ E R
Sbjct: 158 DAPGGAVVLPLVLEVEVVFTQLEVVTRNLPLVVEELLGTSNALDARSLEFAFQPETEECR 217
Query: 465 KSQVLFSVTRGARHGEL--ELDIPGAQAR-----------KMFTLLDVVNRKARFIHDGS 511
+L + R+GEL +PG K F L V R +
Sbjct: 218 VG-ILSGLGALPRYGELLHYPQVPGGAREGGAPETLLMDCKAFQELGVRYRHTAASRSPN 276
Query: 512 EDTSDQLVLEVSVTARVPMPSCLRRGQTYLLPIQVNPVNDPPHIIFPHGSLMVILEHTQK 571
D +V S A V P+ R L+ I+ N P F +M + +
Sbjct: 277 RDWIPMVVELRSRGAPVGSPALKREHFQVLVRIRGGAENTAPKPSFVAMMMMEVDQFVLT 336
Query: 572 PLGPEVFQAYDPDSACEGLTFQVLGTSSGLPVE----RRDQPGEPATEFSCRELEAGSLV 627
L P++ A D +S + L F + TS P + D P + F+ R+L +
Sbjct: 337 ALTPDMLAAEDAESPSDLLIFNL--TSPFQPGQGYLVSTDDRSLPLSSFTQRDLRLLKIA 394
Query: 628 YVHRGGPAQD--------LTFRVSDGLQASPPATLKVVAIRP----AIQIHRSTGLRLAQ 675
Y P++D L V D A+ +V ++P A + R+TGL L +
Sbjct: 395 YQP---PSEDSDQERLFELELEVVDLEGAASDPFAFMVVVKPMNTMAPVVTRNTGLILYE 451
Query: 676 GSAMPILPANLSVETNAVGQDV----SVLFRVTGALQFGELQKQGAGGVEGAEWWATQAF 731
G + P+ S N V D +V V L+ G L GA A ++F
Sbjct: 452 GQSRPLTGPAGSGPQNLVISDEDDLEAVRLEVVAGLRHGHLVILGASSGSSAP----KSF 507
Query: 732 HQRDVEQGRVRYLSTDPQHHAYDTVENLALE-VQVGQEILSNLSFPVTI----------- 779
++ G+V Y D D NL L V G FP+T+
Sbjct: 508 TVAELAAGQVVYQHDDRDGSLSD---NLVLRMVDGGGRHQVQFLFPITLVPVDDQPPVLN 564
Query: 780 --------QRATVWMLRLEPLHTQNTQQETLTTAHLEATLEEAG------PSPPTFHYEV 825
+ TV +L L T ++L LE+ G PP E+
Sbjct: 565 ANTGLTLAEGETVPILPLSLSATDMDSDDSLLLFVLESPFLTTGHLLLRQTHPPHEKQEL 624
Query: 826 VQAPRKGNLQLQGTRLSDGQGFTQDDIQAGRVTYGATARASEA-VEDTFRFRVTA---PP 881
++ + +++ Q Q DI GR+ Y + S V D F FRV PP
Sbjct: 625 LRGLWRKEGAFYERTVTEWQ---QQDITEGRLFYRHSGPHSPGPVTDQFTFRVQDNHDPP 681
Query: 882 YFSPLYTFPIHIGG----DPDAPVLTNVLLVVPEGGEGVLSADHLFVKSLNS--ASYLYE 935
S L F I I P+ + +VV E L L L++ Y
Sbjct: 682 NQSGLQRFVIRIHPVDRLPPELGSGCPLRMVVQESQLTPLRKKWLRYTDLDTDDRELRYT 741
Query: 936 VMERPRH----------GRLAWRGTQDKTTMVTSFTNEDLLRGRLVYQHDDSETTEDDIP 985
V + P G L T + + +VT FT + ++ Y+ E
Sbjct: 742 VTQSPTDTDENHLPAPLGTLVL--TDNPSVVVTHFTQAQINHHKIAYRPPGQELG----- 794
Query: 986 FVATRQGESS---GDMAWEEVRGVFRVAIQPVNDHAPVQTISRIFHVARGGRRLLTTDDV 1042
VATR + D A G F + + PV D+ P + ++ F + G +L+ ++
Sbjct: 795 -VATRVAQFQFQVEDRAGNVAPGTFTLYLHPV-DNQPPEILNTGFTIQEKGHHILSETEL 852
Query: 1043 AFSDADSGFADAQLVLTRKDLLFGSIVAVDEPTRPIYRFTQEDLRKRRVLFVHSGADRGW 1102
+D D+ A LT+ G + + F ED+++ RV + H+G D+
Sbjct: 853 HVNDVDTDVAHISFTLTQAPK-HGHMRVSGQILHVGGLFHLEDIKQGRVSYAHNG-DKSL 910
Query: 1103 IQ---LQVSDGQHQATALLEVQASE-----PYLRVANG---SSLVVPQGGQGTIDTAVLH 1151
L+VSD H L V P L G S L V + G I V+
Sbjct: 911 TDSCSLEVSDRHHVVPITLRVNVRPVDDEVPILSHPTGTLESYLDVLENGATEITANVIK 970
Query: 1152 LDTNLDIRSGDEVH--YHVTAGPRWGQLVRAGQPATAFSQQDLLDGAVLYSHN----GSL 1205
TN + D++ + + P +G+++ G PA F+Q+D+L+G+V+Y+H G L
Sbjct: 971 -GTNEET---DDLMLTFLLEDPPLYGEILVNGIPAEQFTQRDILEGSVVYTHTSGEIGLL 1026
Query: 1206 SPRDTMAFSVE--------AGPVHTDATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEI 1257
D+ S+ G T+ VTI AP ++ +++ V +G+ + I
Sbjct: 1027 PKADSFNLSLSDMSQEWRIGGNTIQGVTIWVTILPVDSQAP-EIFVGEQLIVMEGDKSVI 1085
Query: 1258 RRDQLEAAQEAVPPADIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGR 1317
+ A DI+ ++ P++GY+ +S +++ + + +F+ + + G
Sbjct: 1086 TSVHISAEDVDSLNDDILCTIVIQPTSGYVENISPAPGSEKSRAGIAISAFNLKDLRQGH 1145
Query: 1318 VLYL---HSRPEAWSDAFSLDVASGLGAPLEGVLVELEVLPA---AIPLEAQNFSVPEGG 1371
+ Y+ H E D F + G+ E + ++P + + F V EG
Sbjct: 1146 INYVQSVHKGVEPVEDRFVFRCSDGINFS-ERQFFPIVIIPTNDEQPEMFMREFMVMEGM 1204
Query: 1372 SLTLAPPLLRVSGPYFPTLLGLSLQVLEPPQHGALQKEDGPQARTLSAFSW-RMVEEQLI 1430
SL + P+L + P L L+ + + P HG + + + +F+ +++E I
Sbjct: 1205 SLVIDTPILNAADADVP-LDDLTFTITQFPTHGHIMNQLINGTVLVESFTLDQIIESSSI 1263
Query: 1431 RYVHDGSETLTDSFVLMANASEMDRQSHPVAFTVT--VLPVNDQPPILTTNTGLQMWEGA 1488
Y HD SET DSFV+ ++ H V TV V+PV+D+ P +T N GL++ G
Sbjct: 1264 IYEHDDSETQEDSFVI-----KLTDGKHSVEKTVLIIVIPVDDETPRMTINNGLEIEIGD 1318
Query: 1489 TAPIPAEALRSTDGDSGSEDLVYTIEQ-PSNGRVVLRGAPG-----TEVRSFTQAQLDGG 1542
T I + L +TD DS + LVY I P +G + R G T +FTQ ++D
Sbjct: 1319 TKIINNKILMATDLDSEDKSLVYIIRYGPGHGLLQRRKPTGAFENITLGMNFTQDEVDRN 1378
Query: 1543 LVLFSHRGT--LDGGFRFRLSDGEHTSPGHFFRVT-----------AQKQVLLSLKGSQT 1589
L+ + H G + +F ++DG + +F V+ K V L G T
Sbjct: 1379 LIQYVHLGQEGIRDLIKFDVTDGINPLIDRYFYVSIGSIDIVFPDVISKGVSLKEGGKVT 1438
Query: 1590 LTVCPGSVQPLSSQTLRASSSAGTDPQLLLYRVVRGPQLGRLFHAQQDSTGEALVNFTQA 1649
LT L ++S + + L++ + R P G L D G ++ +FTQ
Sbjct: 1439 LTT-----------DLLSTSDLNSPDENLVFTITRAPMRGHL--ECTDQPGVSITSFTQL 1485
Query: 1650 EVYAGNILYEHEMPPEPFWEAHDTLELQLSSPPARDVAATLAVAVS-FEAACPQRPSHLW 1708
++ I Y H E D+ E Q++ V T +++S + P H
Sbjct: 1486 QLAGNKIYYIHTADDE---VKMDSFEFQVTD-GRNPVFRTFRISISDVDNKKPVVTIH-- 1539
Query: 1709 KNKGLWVPEGQRARITVAALDASNLLASVPSPQRSEHDVLFQVTQFPSRGQLLVSE-EPL 1767
L V E + IT L +V + + F +TQ P G LL + P+
Sbjct: 1540 ---KLVVSESENKLITPFEL-------TVEDRDTPDKLLKFTITQVPIHGHLLFNNTRPV 1589
Query: 1768 HAGQPHFLQSQLAAGQLVYAHGGGGTQQDGFHFRAHLQGPAGASVAGPQT------SEAF 1821
F + L + Y H G + +D F F G P T +
Sbjct: 1590 MV----FTKQDLNENLISYKHDGTESSEDSFSFTV-TDGTHTDFYVFPDTVFETRRPQVM 1644
Query: 1822 AITVRDVNERPPQ----PQASVPLRLTRGSRA-PISRAQLSVVDPDSAPGEIEYEVQRAP 1876
I V V+ PQ AS L G I+ L V D DS + + V AP
Sbjct: 1645 KIQVLAVDNSVPQIAVNKGASTLRTLATGHLGFMITSKILKVEDRDSLHISLRFIVTEAP 1704
Query: 1877 HNGFLSLVGGGLGPVTRFTQADVDSGRLAFV--ANGSSVAGIFQLSMSDGASPPL 1929
+G+L + G +T+FTQAD+D ++ +V ++ + +F ++ DG L
Sbjct: 1705 QHGYLLNLDKGNHSITQFTQADIDDMKICYVLREGANATSDMFYFAVEDGGGNKL 1759
Score = 103 bits (257), Expect = 2e-21
Identities = 167/720 (23%), Positives = 285/720 (39%), Gaps = 115/720 (15%)
Query: 1375 LAPPLLRVSGPYFPT-LLGLSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYV 1433
L P +L P+ LL +L P G L D ++ LS+F+ R + I Y
Sbjct: 338 LTPDMLAAEDAESPSDLLIFNLTSPFQPGQGYLVSTDD-RSLPLSSFTQRDLRLLKIAYQ 396
Query: 1434 HDGSETLTDS-FVLMANASEMD-RQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAP 1491
++ + F L +++ S P AF V V P+N P++T NTGL ++EG + P
Sbjct: 397 PPSEDSDQERLFELELEVVDLEGAASDPFAFMVVVKPMNTMAPVVTRNTGLILYEGQSRP 456
Query: 1492 IPAEALRSTDGDSGSEDLVYTIEQP------------SNGRVVLRGAPG--TEVRSFTQA 1537
+ A SG ++LV + E +G +V+ GA + +SFT A
Sbjct: 457 LTGPA------GSGPQNLVISDEDDLEAVRLEVVAGLRHGHLVILGASSGSSAPKSFTVA 510
Query: 1538 QLDGGLVLFSHR---GTLDGGFRFRLSDG------EHTSPGHFFRVTAQKQVLLSLKGSQ 1588
+L G V++ H G+L R+ DG + P V Q VL + G
Sbjct: 511 ELAAGQVVYQHDDRDGSLSDNLVLRMVDGGGRHQVQFLFPITLVPVDDQPPVLNANTG-- 568
Query: 1589 TLTVCPGSVQPLSSQTLRASSSAGTDPQLLLYRVVRGPQL--GRLFHAQQDSTGE----- 1641
LT+ G P+ +L A+ +D LLL+ V+ P L G L Q E
Sbjct: 569 -LTLAEGETVPILPLSLSATDM-DSDDSLLLF-VLESPFLTTGHLLLRQTHPPHEKQELL 625
Query: 1642 -------------ALVNFTQAEVYAGNILYEHEMP--PEPFWEAHDTLELQLSSPPARDV 1686
+ + Q ++ G + Y H P P P + PP +
Sbjct: 626 RGLWRKEGAFYERTVTEWQQQDITEGRLFYRHSGPHSPGPVTDQFTFRVQDNHDPPNQSG 685
Query: 1687 AATLAVAV--------SFEAACPQRPSHLWKNKGLWVPEGQRARITVAALDASNLLASVP 1738
+ + + CP R + V E Q + L ++L
Sbjct: 686 LQRFVIRIHPVDRLPPELGSGCPLR---------MVVQESQLTPLRKKWLRYTDL----- 731
Query: 1739 SPQRSEHDVLFQVTQFPSR----------GQLLVSEEPLHAGQPHFLQSQLAAGQLVYAH 1788
+ ++ + VTQ P+ G L++++ P HF Q+Q+ ++ Y
Sbjct: 732 --DTDDRELRYTVTQSPTDTDENHLPAPLGTLVLTDNP-SVVVTHFTQAQINHHKIAYRP 788
Query: 1789 GGG--GTQQDGFHFRAHLQGPAGASVAGPQTSEAFAITVRDVNERPPQPQASVPLRLTRG 1846
G G F+ ++ AG G F + + V+ +PP+ + +
Sbjct: 789 PGQELGVATRVAQFQFQVEDRAGNVAPG-----TFTLYLHPVDNQPPEI-LNTGFTIQEK 842
Query: 1847 SRAPISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQADVDSGRLAF 1906
+S +L V D D+ I + + +AP +G + + G L F D+ GR+++
Sbjct: 843 GHHILSETELHVNDVDTDVAHISFTLTQAPKHGHMRVSGQILHVGGLFHLEDIKQGRVSY 902
Query: 1907 VANGS-SVAGIFQLSMSDGASPPLPMSLAVDILPSAIEVQ--------LRAPLEVPQALG 1957
NG S+ L +SD +P++L V++ P EV L + L+V + G
Sbjct: 903 AHNGDKSLTDSCSLEVSD-RHHVVPITLRVNVRPVDDEVPILSHPTGTLESYLDVLEN-G 960
Query: 1958 RSSLSQQQLRVVSDREEPEAAYRLIQGPQ-YGHLLVGGRPTSAFSQFQIDQGEVVFAFTN 2016
+ ++ ++ ++ + L++ P YG +LV G P F+Q I +G VV+ T+
Sbjct: 961 ATEITANVIKGTNEETDDLMLTFLLEDPPLYGEILVNGIPAEQFTQRDILEGSVVYTHTS 1020
>gi|169167211 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
sapiens]
Length = 2139
Score = 203 bits (516), Expect = 2e-51
Identities = 256/1044 (24%), Positives = 428/1044 (40%), Gaps = 109/1044 (10%)
Query: 950 TQDKTTMVTSFTNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGVFRV 1009
T T++ FT + + ++ YQ + T Q E D A V G F +
Sbjct: 765 TDSPDTLIMHFTQAQVNQHKVAYQPPQKLGIAPRV-VQFTYQVE---DAAGNSVPGTFTL 820
Query: 1010 AIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIV 1069
+QPV D+ P + +R F + GG L+++++ +D D+ +L R G +
Sbjct: 821 FLQPV-DNQPPEVTNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQ-HGHLQ 878
Query: 1070 AVDEPTRPIYRFTQEDLRKRRVLFVHSGADR----GWIQLQVSDGQHQATALLEVQAS-- 1123
P F Q D+ V + H G D+ L+VSDG H + +
Sbjct: 879 YFKRCMVPGESFMQADVINGSVSYQH-GRDQTTTSDTFHLEVSDGVHHIPITIPISVHPN 937
Query: 1124 ----EPYLRVANGS----SLVVPQGGQGTIDTAVLHLDTNLDIRSGD-EVHYHVTAGPRW 1174
P + + + S S+ V + I V+H D+ GD + + V P+
Sbjct: 938 VANRSPRISLRSSSLLDVSIDVLENKATEITMGVIH-GKRKDV--GDLMLSFIVKDSPKL 994
Query: 1175 GQLVRAGQPATAFSQQDLLDGAVLYSHN----GSLSPRDTMAFS--------VEAGPVHT 1222
G ++ G P F+Q+DL++G V Y+H G D + V +
Sbjct: 995 GTILVNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIE 1054
Query: 1223 DATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEIRRDQLEAAQEAVPPADIVFSVKSPP 1282
+QVT+ + P LV I V++GE + L +++ +V S P
Sbjct: 1055 KVQVQVTVLPVDNVGPKVLVGESFI-VYEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQP 1113
Query: 1283 SAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLY---LHSRPEAWSDAFSLDVASG 1339
++GYL ++ + S P+ +FS + + Y +H E D F+ + G
Sbjct: 1114 ASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDG 1173
Query: 1340 LGAPLEGVLVELEVLPA---AIPLEAQNFSVPEGGSLTLAPPLLRVSGPYFPTLLGLSLQ 1396
+ V + +LP L A F V EG SL + LL + P L Q
Sbjct: 1174 INFS-PNVFFPIIILPTNDEQPKLFAHEFKVLEGMSLVIDTQLLNGADADLPPN-ELHFQ 1231
Query: 1397 VLEPPQHGALQKEDGPQARTLSAFSWRMVEE-QLIRYVHDGSETLTDSF-VLMANASEMD 1454
+ P+HG + ++ ++ + +F+ + ++E I Y HD SET DSF V +++
Sbjct: 1232 LTALPRHGRIIQQLATGSQPIHSFTLKEIQEASTIVYEHDDSETKEDSFEVWLSDGKHTT 1291
Query: 1455 RQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEALRSTDGDSGSEDLVYTIE 1514
+ P+ T+ V+D+ P LT N GL++ +G + I L++TD DS + L + +
Sbjct: 1292 HRKVPIVVTL----VDDETPHLTVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLH 1347
Query: 1515 Q-PSNGRVVLRGAPGTEVR-------SFTQAQLDGGLVLFSHRGT--LDGGFRFRLSDGE 1564
P G + P EVR +FTQ +++ GL+ + H G + +F ++DG
Sbjct: 1348 SGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGV 1407
Query: 1565 HTSPGHFFRVT-AQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASSSAGTDPQLLLYRVV 1623
+T H+F VT + S+ +T+ G+ L++ L S +D + +
Sbjct: 1408 NTLTDHYFYVTIGNLDSVFPEVISKRITLIEGARVTLTNNLLTNSDINSSDEH--HFSIT 1465
Query: 1624 RGPQLGRLFHAQQDSTGEALVNFTQAEVYAGNILYEHEMPPEPFWEAHDTLELQLSSPPA 1683
R P LG L D GE + +FTQ ++ + I Y H E + D+ E Q+
Sbjct: 1466 RAPSLGHL--ESSDYAGEPIASFTQLQLASNKISYVHTSNDE---KKMDSFEFQVIG-EL 1519
Query: 1684 RDVAATLAVAVS-FEAACPQRPSHLWKNKGLWVPEGQRARITVAALDA---SNLLASVPS 1739
V T + ++ + P H R+T+ D+ + L +V
Sbjct: 1520 YPVFRTFRIFITDVDNKKPILTIH---------------RLTLQKEDSQLITLLELTVED 1564
Query: 1740 PQRSEHDVLFQVTQFPSRGQLLVS-EEPLHAGQPHFLQSQLAAGQLVYAHGGGGTQQDGF 1798
+ +LF +TQ P G++L + P+ F + L + Y H G T +D F
Sbjct: 1565 SDTPDDLILFTITQVPMHGKILYNGSRPVTT----FTKQDLNKNLISYKHDGSETTEDSF 1620
Query: 1799 HFRAHLQGPAGASVAGPQTS------EAFAITVRDVNERPPQ----PQASVPLRLTRGSR 1848
G P T+ + + +R ++ R PQ A RL G
Sbjct: 1621 SLTV-TDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHM 1679
Query: 1849 A-PISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQADVDSGRLAFV 1907
I+ L D DS ++Y+V R P +GF+ G G FTQAD+D ++++V
Sbjct: 1680 GFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTRVFTQADIDEMKISYV 1739
Query: 1908 ANGSSVAG--IFQLSMSDGASPPL 1929
N S A IF S+ D L
Sbjct: 1740 LNEGSNASKDIFYFSVEDNGGNKL 1763
Score = 178 bits (452), Expect = 5e-44
Identities = 281/1166 (24%), Positives = 483/1166 (41%), Gaps = 161/1166 (13%)
Query: 956 MVTSFTNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGVFRVAIQPVN 1015
+VT + D++ GRL Y+H + + + +A + D + +F + +QPV+
Sbjct: 641 VVTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHV-QDDHDPPNLSKQHIFTIKVQPVD 699
Query: 1016 DHAPV--------QTIS--RIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKD--- 1062
+P T+ ++ H + R + D SD + + + T D
Sbjct: 700 ILSPQLYPGTTLEMTVQEYQLTHFQKNFLRYIDQD----SDDQNLWYTLLTLPTDTDGNH 755
Query: 1063 -LLFGSIVAVDEPTRPIYRFTQEDLRKRRVLF---VHSGADRGWIQL--QVSDGQHQA-- 1114
+ G IV D P I FTQ + + +V + G +Q QV D +
Sbjct: 756 QVRAGEIVLTDSPDTLIMHFTQAQVNQHKVAYQPPQKLGIAPRVVQFTYQVEDAAGNSVP 815
Query: 1115 -TALLEVQASEPYLRVANGSSLVVPQGGQGTIDTAVLHL-DTNLDIRSGDEVHYHVTAGP 1172
T L +Q + + +GG + + LH+ D + DI D++ + + GP
Sbjct: 816 GTFTLFLQPVDNQPPEVTNRGFAILEGGSFNLSSNELHVTDPDTDI---DQIVFILVRGP 872
Query: 1173 RWGQL---VRAGQPATAFSQQDLLDGAVLYSH-NGSLSPRDTMAFSVEAGPVHTDATLQV 1228
+ G L R P +F Q D+++G+V Y H + DT V G H T+ +
Sbjct: 873 QHGHLQYFKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVHHIPITIPI 932
Query: 1229 T----IALEGPLAPLK--LVRHKKIYVFQGEAAEIRRDQLEAAQEAVPPADIVFSVKSPP 1282
+ +A P L+ + I V + +A EI + ++ V + F VK P
Sbjct: 933 SVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLMLSFIVKDSP 992
Query: 1283 SAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLYLHSRPEA----WSDAFSLDVAS 1338
G +++ P + F+QE + GRV Y H+ E DAFSL ++
Sbjct: 993 KLGTILVNGL-----------PTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSK 1041
Query: 1339 GL------GAPLEGVLVELEVLP----AAIPLEAQNFSVPEG--GSLTLAPPLLRVSGPY 1386
+ +E V V++ VLP L ++F V EG SLTL + +
Sbjct: 1042 DSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVLVGESFIVYEGEKNSLTLQHLHVEDVDTH 1101
Query: 1387 FPTLLGLSLQVLEPPQHGALQK-------EDGPQARTLSAFSWRMVEEQLIRYV---HDG 1436
LL V P G L+K + +SAFS R ++ + I YV H G
Sbjct: 1102 QDELL---CTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHKG 1158
Query: 1437 SETLTDSFVLMANASEMDRQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEA 1496
E D F S+ S V F + +LP ND+ P L + ++ EG + I +
Sbjct: 1159 VEPQEDQFTFY--CSDGINFSPNVFFPIIILPTNDEQPKLFAHE-FKVLEGMSLVIDTQL 1215
Query: 1497 LRSTDGDSGSEDLVYTIEQ-PSNGRVVLRGAPGTE-VRSFTQAQL-DGGLVLFSH--RGT 1551
L D D +L + + P +GR++ + A G++ + SFT ++ + +++ H T
Sbjct: 1216 LNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEIQEASTIVYEHDDSET 1275
Query: 1552 LDGGFRFRLSDGEHTSPGHF-FRVTAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASSS 1610
+ F LSDG+HT+ VT L + L V G + ++++ L+A +
Sbjct: 1276 KEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKGHSEIITNRILKA-TD 1334
Query: 1611 AGTDPQLLLYRVVRGPQLGRLFHAQQDSTGEAL------VNFTQAEVYAGNILYEHEMPP 1664
+D + L + + GPQ G L + GE +NFTQ E+ G I Y H
Sbjct: 1335 LDSDDKSLSFVLHSGPQQG-LLQRLRKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQE 1393
Query: 1665 EPFWEAHDTLELQLSSPPARDVAATLAVAV-SFEAACPQRPSHLWKNKGLWVPEGQRARI 1723
D ++ ++ V + + ++ P+ S K + + EG R +
Sbjct: 1394 ----GIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVIS-----KRITLIEGARVTL 1444
Query: 1724 TVAALDASNLLASVPSPQRSEHDVLFQVTQFPSRGQLLVSEEPLHAGQP--HFLQSQLAA 1781
T +NLL + EH F +T+ PS G L S+ +AG+P F Q QLA+
Sbjct: 1445 T------NNLLTNSDINSSDEHH--FSITRAPSLGHLESSD---YAGEPIASFTQLQLAS 1493
Query: 1782 GQLVYAHGGGGTQQ-DGFHFRAHLQGPAGASVAGP--QTSEAFAITVRDVNERPPQPQAS 1838
++ Y H ++ D F F+ V G F I + DV+ + P
Sbjct: 1494 NKISYVHTSNDEKKMDSFEFQ----------VIGELYPVFRTFRIFITDVDNKKPILTIH 1543
Query: 1839 VPLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQAD 1898
L L + I+ +L+V D D+ I + + + P +G ++ G PVT FT+ D
Sbjct: 1544 -RLTLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHG--KILYNGSRPVTTFTKQD 1600
Query: 1899 VDSGRLAFVANGS-SVAGIFQLSMSDGASPP---LPMSLAVDILPSAIEVQLRA-PLEVP 1953
++ +++ +GS + F L+++DG LP + P + VQ+R+ +P
Sbjct: 1601 LNKNLISYKHDGSETTEDSFSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLP 1660
Query: 1954 Q--------ALGRSSLSQQQLRVVS------DREEPE--AAYRLIQGPQYGHLL---VGG 1994
Q AL R + S D++ P Y++ +GP++G ++ +G
Sbjct: 1661 QITTNRGAPALKRLHTGHMGFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGN 1720
Query: 1995 RPTSAFSQFQIDQGEVVFAFTNFSSS 2020
+ T F+Q ID+ ++ + S++
Sbjct: 1721 QSTRVFTQADIDEMKISYVLNEGSNA 1746
Score = 129 bits (323), Expect = 4e-29
Identities = 204/908 (22%), Positives = 368/908 (40%), Gaps = 111/908 (12%)
Query: 825 VVQAPRKGNLQLQGTRLSDGQGFTQDDIQAGRVTYGATARASEAVEDTFRFRVTAPPYFS 884
+V+ P+ G+LQ + G+ F Q D+ G V+Y R DTF V+ +
Sbjct: 868 LVRGPQHGHLQYFKRCMVPGESFMQADVINGSVSY-QHGRDQTTTSDTFHLEVSDGVHHI 926
Query: 885 PLYTFPIHI-----GGDPDAPVLTNVLLVVP------EGGEGVLSADHLFVKSLNSASYL 933
P+ T PI + P + ++ LL V + E + H K +
Sbjct: 927 PI-TIPISVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLMLS 985
Query: 934 YEVMERPRHGRLAWRGTQDKTTMVTSFTNEDLLRGRLVYQHDDSET----TEDDIPFVAT 989
+ V + P+ G + G + FT EDL+ GR+ Y H E D + +
Sbjct: 986 FIVKDSPKLGTILVNGLPTE-----RFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILS 1040
Query: 990 RQGES--SGDMAWEEVRGVFRVAIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDA 1047
+ G+ E+V+ +V + PV++ P + F V G + LT + D
Sbjct: 1041 KDSYQWVVGNSIIEKVQ--VQVTVLPVDNVGPKVLVGESFIVYEGEKNSLTLQHLHVEDV 1098
Query: 1048 DSGFADAQLVLTRKDLLFGSIVAV--------DEPTRPIYRFTQEDLRKRRVLFV---HS 1096
D+ D L G + + + PI F+ D++ R + +V H
Sbjct: 1099 DT-HQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHK 1157
Query: 1097 GAD--RGWIQLQVSDGQHQA------TALLEVQASEPYL-----RVANGSSLVVPQGGQG 1143
G + SDG + + +L +P L +V G SLV
Sbjct: 1158 GVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVLEGMSLV------- 1210
Query: 1144 TIDTAVLH-LDTNLDIRSGDEVHYHVTAGPRWG----QLVRAGQPATAFSQQDLLDGA-V 1197
IDT +L+ D +L +E+H+ +TA PR G QL QP +F+ +++ + + +
Sbjct: 1211 -IDTQLLNGADADL---PPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEIQEASTI 1266
Query: 1198 LYSHNGSLSPRDTMAFSVEAGPVHTDATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEI 1257
+Y H+ S + D+ + G T + + + L P L + + V +G + I
Sbjct: 1267 VYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETP-HLTVNNGLKVEKGHSEII 1325
Query: 1258 RRDQLEAAQEAVPPADIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGR 1317
L+A + F + S P G L + R + +L +F+Q+ ++ G
Sbjct: 1326 TNRILKATDLDSDDKSLSFVLHSGPQQGLLQRL-RKPRGEVRNNLTLGMNFTQDEINRGL 1384
Query: 1318 VLYLHSRPEAWSDAFSLDVASGLGAPLEGVL-VELEVLPAAIP-LEAQNFSVPEGGSLTL 1375
+ Y+H+ E D DV G+ + V + L + P + ++ ++ EG +TL
Sbjct: 1385 ICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVISKRITLIEGARVTL 1444
Query: 1376 APPLLRVSGPYFPTLLGLSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVH- 1434
LL S + + P G L+ D +++F+ + I YVH
Sbjct: 1445 TNNLLTNSD--INSSDEHHFSITRAPSLGHLESSD-YAGEPIASFTQLQLASNKISYVHT 1501
Query: 1435 DGSETLTDSFVLMANASEMDRQSHPV--AFTVTVLPVNDQPPILTTNTGLQMWEGATAPI 1492
E DSF ++ + +PV F + + V+++ PILT + L + + + I
Sbjct: 1502 SNDEKKMDSFEF-----QVIGELYPVFRTFRIFITDVDNKKPILTIHR-LTLQKEDSQLI 1555
Query: 1493 PAEALRSTDGDSGSEDLVYTIEQ-PSNGRVVLRGAPGTEVRSFTQAQLDGGLVLFSHRG- 1550
L D D+ + +++TI Q P +G+++ G+ V +FT+ L+ L+ + H G
Sbjct: 1556 TLLELTVEDSDTPDDLILFTITQVPMHGKILYNGS--RPVTTFTKQDLNKNLISYKHDGS 1613
Query: 1551 -TLDGGFRFRLSDGEHTS----PGHFFRVTAQKQVLLSLKGSQT----LTVCPGSVQ--- 1598
T + F ++DG HT P + + + ++ +T G+
Sbjct: 1614 ETTEDSFSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKR 1673
Query: 1599 --------PLSSQTLRASSSAGTDPQLLLYRVVRGPQLGRLFHAQQDSTGEALVNFTQAE 1650
++S++L+A + +LL Y+V RGP+ G F + ++ FTQA+
Sbjct: 1674 LHTGHMGFLITSKSLKAEDQ-DSPHRLLKYKVTRGPEHG--FIIKTGLGNQSTRVFTQAD 1730
Query: 1651 VYAGNILY 1658
+ I Y
Sbjct: 1731 IDEMKISY 1738
Score = 116 bits (290), Expect = 3e-25
Identities = 213/973 (21%), Positives = 374/973 (38%), Gaps = 117/973 (12%)
Query: 546 VNPVNDPPHIIFPHGSLMVILEHTQKPLGPEVFQAYDPDSACEGLTFQVLGTSSGLPVER 605
+ PV++ P + G ILE L DPD+ + + F ++ ++
Sbjct: 822 LQPVDNQPPEVTNRG--FAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQY 879
Query: 606 RDQPGEPATEFSCRELEAGSLVYVH-RGGPAQDLTFR--VSDGLQASP---PATL--KVV 657
+ P F ++ GS+ Y H R TF VSDG+ P P ++ V
Sbjct: 880 FKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNVA 939
Query: 658 AIRPAIQIHRSTGLRLA----QGSAMPILPANLSVETNAVGQDVSVLFRVTGALQFGELQ 713
P I + S+ L ++ + A I + + VG D+ + F V + + G +
Sbjct: 940 NRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVG-DLMLSFIVKDSPKLGTIL 998
Query: 714 KQGAGGVEGAEWWATQAFHQRDVEQGRVRYLST------DPQHHAYDTV-ENLALEVQVG 766
G T+ F Q D+ GRV Y T QH A+ + + + VG
Sbjct: 999 VNGL---------PTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSKDSYQWVVG 1049
Query: 767 QEILSNLSFPVT---IQRATVWMLRLEPLHTQNTQQETLTTAHLEATLEEAGPSPPTFHY 823
I+ + VT + +L E ++ +LT HL +E+
Sbjct: 1050 NSIIEKVQVQVTVLPVDNVGPKVLVGESFIVYEGEKNSLTLQHLH--VEDVDTHQDELLC 1107
Query: 824 EVVQAPRKGNLQ----LQGTRLSDG----QGFTQDDIQAGRVTY-GATARASEAVEDTFR 874
V P G L+ G+++S F+ DIQ + Y + + E ED F
Sbjct: 1108 TVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQEDQFT 1167
Query: 875 FRVTAPPYFSPLYTFPIHI-GGDPDAPVLTNVLLVVPEGGEGVLSADHL--FVKSLNSAS 931
F + FSP FPI I + + P L V EG V+ L L
Sbjct: 1168 FYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVLEGMSLVIDTQLLNGADADLPPNE 1227
Query: 932 YLYEVMERPRHGRLAWR---GTQDKTTMVTSFTNEDLLR-GRLVYQHDDSETTEDDIPFV 987
+++ PRHGR+ + G+Q + SFT +++ +VY+HDDSET ED V
Sbjct: 1228 LHFQLTALPRHGRIIQQLATGSQP----IHSFTLKEIQEASTIVYEHDDSETKEDSFE-V 1282
Query: 988 ATRQGESSGDMAWEEVRGVFRVAIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDA 1047
G+ + + + V+D P T++ V +G ++T + +D
Sbjct: 1283 WLSDGKHT-------THRKVPIVVTLVDDETPHLTVNNGLKVEKGHSEIITNRILKATDL 1335
Query: 1048 DSGFADAQLVLTRKDLLFGSIVAVDEPTRPI-------YRFTQEDLRKRRVLFVHSGADR 1100
DS VL G + + +P + FTQ+++ + + ++H+G +
Sbjct: 1336 DSDDKSLSFVL-HSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQEG 1394
Query: 1101 --GWIQLQVSDGQHQAT---ALLEVQASEPYLRVANGSSLVVPQGGQGTIDTAVLHLDTN 1155
I+ V+DG + T + + + + + +G + T+ +L TN
Sbjct: 1395 IVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVISKRITLIEGARVTLTNNLL---TN 1451
Query: 1156 LDIRSGDEVHYHVTAGPRWGQLVR---AGQPATAFSQQDLLDGAVLYSHNGSLSPR-DTM 1211
DI S DE H+ +T P G L AG+P +F+Q L + Y H + + D+
Sbjct: 1452 SDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQLQLASNKISYVHTSNDEKKMDSF 1511
Query: 1212 AFSVEAGPVHTDATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEIRRDQLEAAQEAVPP 1271
F V T ++ I P+ + ++ + + ++ I +L P
Sbjct: 1512 EFQVIGELYPVFRTFRIFITDVDNKKPILTIH--RLTLQKEDSQLITLLELTVEDSDTPD 1569
Query: 1272 ADIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLYLHSRPEAWSDA 1331
I+F++ P G ++ PV +F+++ ++ + Y H E D+
Sbjct: 1570 DLILFTITQVPMHGKILY----------NGSRPVTTFTKQDLNKNLISYKHDGSETTEDS 1619
Query: 1332 FSLDVASGLGAPL----EGVLVELEVLPAAIPLEAQNFSVPEGGSLTLAPPLLRVSGPYF 1387
FSL V G + L + + + + + +P+ + AP L R+ +
Sbjct: 1620 FSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHM 1679
Query: 1388 PTLLG---------------LSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRY 1432
L+ L +V P+HG + K G ++ F+ ++E I Y
Sbjct: 1680 GFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIK-TGLGNQSTRVFTQADIDEMKISY 1738
Query: 1433 V-HDGSETLTDSF 1444
V ++GS D F
Sbjct: 1739 VLNEGSNASKDIF 1751
Score = 103 bits (256), Expect = 3e-21
Identities = 157/711 (22%), Positives = 286/711 (40%), Gaps = 112/711 (15%)
Query: 1400 PPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVHDGSETLTDS-FVLMANASEMD-RQS 1457
P Q G + D P +S F+ + + E I Y + + F L + D S
Sbjct: 357 PGQQGYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAAS 416
Query: 1458 HPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPA-EALRSTDGDSGSEDLVYTIEQP 1516
P AF VTV +N P+ + N GL ++EG + P+ + ++ +D D+ E + +
Sbjct: 417 DPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSSTHSIPISDKDNLEEVKMAAVRGL 476
Query: 1517 SNGRVVLRGAPGTEVRSFTQAQLDGGLVLFSHRG--TLDGGFRFRLSDGEHTS----PGH 1570
+G++V+ GAP + FT A L G V++ H G T FR+ DG H P
Sbjct: 477 RHGQLVVFGAPAG-CKYFTPADLAAGRVVYQHDGSNTYSDNIIFRMEDGHHQVDFLFPLT 535
Query: 1571 FFRVTAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASSSAGTDPQL---LLYRVVRG-- 1625
V + ++ + G L++ G V +S L A+ D + L + ++G
Sbjct: 536 ILPVDDEPPMVNTNTG---LSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPLKGNE 592
Query: 1626 --PQ-------------LGRLFHAQQD---STGE--------------ALVNFTQAEVYA 1653
PQ LG L Q + ST + + + Q ++
Sbjct: 593 EEPQWELAPGSSHSGHYLGDLLLQQAELPLSTEDEDWHYMEKEGLYEKVVTEWLQRDIME 652
Query: 1654 GNILYEHEMPPEP----------FWEAHDTLELQ------LSSPPARDVAATLAVAVSFE 1697
G + Y H P P + HD L + P ++ L + E
Sbjct: 653 GRLFYRHLGPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDILSPQLYPGTTLE 712
Query: 1698 AACPQ-RPSHLWKNKGLWVPEGQRARITVAALDASNL---LASVPSPQRSEHDVLFQVTQ 1753
+ + +H KN ++ + D NL L ++P+ H V
Sbjct: 713 MTVQEYQLTHFQKNFLRYIDQDS---------DDQNLWYTLLTLPTDTDGNHQV------ 757
Query: 1754 FPSRGQLLVSEEPLHAGQPHFLQSQLAAGQLVYAHGGG-GTQQDGFHFRAHLQGPAGASV 1812
G++++++ P HF Q+Q+ ++ Y G F ++ AG SV
Sbjct: 758 --RAGEIVLTDSP-DTLIMHFTQAQVNQHKVAYQPPQKLGIAPRVVQFTYQVEDAAGNSV 814
Query: 1813 AGPQTSEAFAITVRDVNERPPQPQASVPLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEV 1872
G F + ++ V+ +PP+ + + G +S +L V DPD+ +I + +
Sbjct: 815 PG-----TFTLFLQPVDNQPPEV-TNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFIL 868
Query: 1873 QRAPHNGFLSLVGGGLGPVTRFTQADVDSGRLAFV--ANGSSVAGIFQLSMSDGASPPLP 1930
R P +G L + P F QADV +G +++ + ++ + F L +SDG +P
Sbjct: 869 VRGPQHGHLQYFKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVH-HIP 927
Query: 1931 MSLAVDILPSA------IEVQLRAPLEVPQALGRSSLSQQQLRVVSDREEPEA----AYR 1980
+++ + + P+ I ++ + L+V + + ++ + V+ + + ++
Sbjct: 928 ITIPISVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLMLSFI 987
Query: 1981 LIQGPQYGHLLVGGRPTSAFSQFQIDQGEVVFAFT----NFSSSHDHFRVL 2027
+ P+ G +LV G PT F+Q + G V +A T F HD F ++
Sbjct: 988 VKDSPKLGTILVNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLI 1038
Score = 102 bits (253), Expect = 6e-21
Identities = 216/981 (22%), Positives = 375/981 (38%), Gaps = 175/981 (17%)
Query: 1242 VRHKKIYVFQGEAAEIRRDQLEAAQEAVPPADIVFSVKSPPSAGYLVMVSRGALADEPPS 1301
V ++ + +G + + ++L IVF + P G+L R
Sbjct: 832 VTNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKR--------C 883
Query: 1302 LDPVQSFSQEAVDTGRVLYLHSRPEAW-SDAFSLDVASGLGAPLEGVLVELEVLPAAIPL 1360
+ P +SF Q V G V Y H R + SD F L+V+ G+ +P IP+
Sbjct: 884 MVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGV-----------HHIPITIPI 932
Query: 1361 EAQNFSVPEGGSLTLAPPLLRVSGPYFPTLLGLSLQVLEPPQ--------HGALQK---- 1408
++L +LL +S+ VLE HG +
Sbjct: 933 SVHPNVANRSPRISLRSS----------SLLDVSIDVLENKATEITMGVIHGKRKDVGDL 982
Query: 1409 ------EDGPQARTLSAFSW---RMVEEQLIR----YVHDGSET----LTDSFVLMANAS 1451
+D P+ T+ R +E LI Y H E D+F L+ +
Sbjct: 983 MLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSKD 1042
Query: 1452 EM-----DRQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEALRSTDGDSGS 1506
+ V VTVLPV++ P + ++EG + + L D D+
Sbjct: 1043 SYQWVVGNSIIEKVQVQVTVLPVDNVGPKVLVGESFIVYEGEKNSLTLQHLHVEDVDTHQ 1102
Query: 1507 EDLVYTI-EQPSNGRVV-LRGAPGTE-------VRSFTQAQLDG---GLVLFSHRGT--L 1552
++L+ T+ QP++G + + APG++ + +F+ + V H+G
Sbjct: 1103 DELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQ 1162
Query: 1553 DGGFRFRLSDGEHTSPGHFFRV----TAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRAS 1608
+ F F SDG + SP FF + T +Q L + V G + +Q L +
Sbjct: 1163 EDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLF---AHEFKVLEGMSLVIDTQLLNGA 1219
Query: 1609 SSAGTDPQLLLYRVVRGPQLGRLFHAQQDSTG-EALVNFTQAEVY-AGNILYEHEMPPEP 1666
A P L +++ P+ GR+ QQ +TG + + +FT E+ A I+YEH+
Sbjct: 1220 D-ADLPPNELHFQLTALPRHGRII--QQLATGSQPIHSFTLKEIQEASTIVYEHDDSETK 1276
Query: 1667 FWEAHDTLELQLSSPPARDVAATLAVAVSFEAACPQRPSHLWKNKGLWVPEGQRARITVA 1726
D+ E+ LS V + P HL N GL V +G IT
Sbjct: 1277 ----EDSFEVWLSDGKHTTHRKVPIVVTLVDDETP----HLTVNNGLKVEKGHSEIITNR 1328
Query: 1727 ALDASNLLASVPSPQRSEHDVLFQVTQFPSRGQLLVSEEP-------LHAGQPHFLQSQL 1779
L A++L + + F + P +G L +P L G +F Q ++
Sbjct: 1329 ILKATDL-------DSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGM-NFTQDEI 1380
Query: 1780 AAGQLVYAHGGGGTQQDGFHFRAHLQGPAGASVAGPQTSEAFAITVRDVNERPPQPQASV 1839
G + Y H G Q+G G + T F +T+ +++ P+ S
Sbjct: 1381 NRGLICYIHTG----QEGIVDIIKFDVTDGVNTL---TDHYFYVTIGNLDSVFPEV-ISK 1432
Query: 1840 PLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQADV 1899
+ L G+R ++ L+ D +S+ E + + RAP G L P+ FTQ +
Sbjct: 1433 RITLIEGARVTLTNNLLTNSDINSSD-EHHFSITRAPSLGHLESSDYAGEPIASFTQLQL 1491
Query: 1900 DSGRLAFV--ANGSSVAGIFQLSMSDGASPPLPMSLAVDILPSAIEVQLRAPLEVPQALG 1957
S ++++V +N F+ + G P+ + + I +V + P+ L
Sbjct: 1492 ASNKISYVHTSNDEKKMDSFEFQVI-GELYPVFRTFRIFI----TDVDNKKPILTIHRLT 1546
Query: 1958 RSSLSQQQLRV----VSDREEPE--AAYRLIQGPQYGHLLV-GGRPTSAFSQFQIDQG-- 2008
Q + + V D + P+ + + Q P +G +L G RP + F++ +++
Sbjct: 1547 LQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLI 1606
Query: 2009 ----------EVVFAFTNFSSSHDHFRVLA-LARGVNASAVVNVTVRALLHVWAGGPWPQ 2057
E F+ T +H F VL A + V+ V +R+L PQ
Sbjct: 1607 SYKHDGSETTEDSFSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSL-----DNRLPQ 1661
Query: 2058 GATLRLDPTV--LDAGELA-------------NRTGSVPRFRLLEGPRHGRVVRVPRART 2102
T R P + L G + + + ++++ GP HG +++
Sbjct: 1662 ITTNRGAPALKRLHTGHMGFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGL--- 1718
Query: 2103 EPGGSQLVEQFTQQDLEDGRL 2123
G+Q FTQ D+++ ++
Sbjct: 1719 ---GNQSTRVFTQADIDEMKI 1736
Score = 101 bits (252), Expect = 7e-21
Identities = 162/699 (23%), Positives = 282/699 (40%), Gaps = 64/699 (9%)
Query: 430 QLLTISPLVVAEGGTAWLEWRHVQPTLDLMEAELRKSQVLFSVTRGARHGELELDIPGAQ 489
++L +V EG L +H L + + + + ++L +VT G LE I A
Sbjct: 1071 KVLVGESFIVYEGEKNSLTLQH----LHVEDVDTHQDELLCTVTSQPASGYLE-KIASAP 1125
Query: 490 ARKM---------FTLLDVVNRKARF---IHDGSEDTSDQLVLEVSVTARVPMPSCLRRG 537
KM F+L D+ R + IH G E DQ S +
Sbjct: 1126 GSKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQEDQFTFYCS--------DGINFS 1177
Query: 538 QTYLLPIQVNPVNDPPHIIFPHGSLMVILEHTQKPLGPEVFQAYDPDSACEGLTFQVLGT 597
PI + P ND +F H +LE + ++ D D L FQ+
Sbjct: 1178 PNVFFPIIILPTNDEQPKLFAHE--FKVLEGMSLVIDTQLLNGADADLPPNELHFQLTAL 1235
Query: 598 SS-GLPVERRDQPGEPATEFSCREL-EAGSLVYVHRGGPAQDLTFRV--SDGLQASPPAT 653
G +++ +P F+ +E+ EA ++VY H ++ +F V SDG +
Sbjct: 1236 PRHGRIIQQLATGSQPIHSFTLKEIQEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKV 1295
Query: 654 LKVVAIRPAIQIHRST--GLRLAQGSAMPILPANLSVETNAVGQDVSVLFRVTGALQFGE 711
VV + H + GL++ +G + I+ + T+ D S+ F + Q G
Sbjct: 1296 PIVVTLVDDETPHLTVNNGLKVEKGHS-EIITNRILKATDLDSDDKSLSFVLHSGPQQGL 1354
Query: 712 LQK-QGAGGVEGAEWWATQAFHQRDVEQGRVRYLSTDPQHHAYDTVENLALEVQVGQEIL 770
LQ+ + G F Q ++ +G + Y+ T + V+ + +V G L
Sbjct: 1355 LQRLRKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQE----GIVDIIKFDVTDGVNTL 1410
Query: 771 SNLSFPVTIQRATVWMLRLEPLHTQNTQQETLTTAHLEATLEEAGPSPPTFHYEVVQAPR 830
++ F VTI + + +T + T + S H+ + +AP
Sbjct: 1411 TDHYFYVTIGNLDSVFPEVISKRITLIEGARVTLTNNLLTNSDINSSDE-HHFSITRAPS 1469
Query: 831 KGNLQLQGTRLSDGQGFTQDDIQAGRVTYGATARASEAVEDTFRFRVTAPPYFSPLY-TF 889
G+L+ FTQ + + +++Y T+ E D+F F+V Y P++ TF
Sbjct: 1470 LGHLESSDYAGEPIASFTQLQLASNKISYVHTSN-DEKKMDSFEFQVIGELY--PVFRTF 1526
Query: 890 PIHIGG-DPDAPVLTNVLLVVPEGGEGVLSADHLFVKSLNSAS--YLYEVMERPRHGRLA 946
I I D P+LT L + + +++ L V+ ++ L+ + + P HG++
Sbjct: 1527 RIFITDVDNKKPILTIHRLTLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKIL 1586
Query: 947 WRGTQDKTTMVTSFTNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESS----GDMAWEE 1002
+ G++ VT+FT +DL + + Y+HD SETTED T + D A
Sbjct: 1587 YNGSRP----VTTFTKQDLNKNLISYKHDGSETTEDSFSLTVTDGTHTDFYVLPDTALAT 1642
Query: 1003 VR-GVFRVAIQPVNDHAPVQTISR------IFHVARGGRRLLTTDDVAFSDADSGFADAQ 1055
+ V RV I+ +++ P T +R H G L+T+ + D DS +
Sbjct: 1643 HKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHMG-FLITSKSLKAEDQDSPHRLLK 1701
Query: 1056 LVLTRKDLLFGSIVAVDEPTRPIYRFTQEDLRKRRVLFV 1094
+TR G I+ + FTQ D+ + ++ +V
Sbjct: 1702 YKVTRGP-EHGFIIKTGLGNQSTRVFTQADIDEMKISYV 1739
Score = 97.4 bits (241), Expect = 1e-19
Identities = 275/1342 (20%), Positives = 484/1342 (36%), Gaps = 205/1342 (15%)
Query: 917 LSADHLFVKSLNS--ASYLYEVMERPRH--GRLAWRG----TQDKTTM-VTSFTNEDLLR 967
L+ D L + + S ++ ++ P H G +G T D + V+ FT ++L
Sbjct: 325 LTPDALAAEDVESDPGDLVFNILNAPTHPPGHPGQQGYVVSTDDPLGLPVSFFTQQELRE 384
Query: 968 GRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRG--------VFRVAIQPVNDHAP 1019
++ YQ P GE + E V G F V ++ +N P
Sbjct: 385 LKIAYQ-----------PPAENSHGERLFQLELEVVDGDGAASDPFAFMVTVKSMNTLVP 433
Query: 1020 VQTISRIFHVARG-GRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIVAVDEPTRPI 1078
V + +R + G R L +T + SD D+ + ++ R L G +V P
Sbjct: 434 VASHNRGLVLFEGQSRPLSSTHSIPISDKDN-LEEVKMAAVR-GLRHGQLVVFGAPAGCK 491
Query: 1079 YRFTQEDLRKRRVLFVHSGADR--GWIQLQVSDGQHQATAL-----LEVQASEPYLRVAN 1131
Y FT DL RV++ H G++ I ++ DG HQ L L V P +
Sbjct: 492 Y-FTPADLAAGRVVYQHDGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVDDEPPMVNTNT 550
Query: 1132 GSSLVVPQGGQ-----------GTIDTAVLHLDTNLDIRSGDEV-------------HYH 1167
G SL Q Q + D+ + + N ++ +E HY
Sbjct: 551 GLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPLKGNEEEPQWELAPGSSHSGHYL 610
Query: 1168 ------------VTAGPRWGQLVRAG---QPATAFSQQDLLDGAVLYSHNGSLSPRDTM- 1211
T W + + G + T + Q+D+++G + Y H G SP+ M
Sbjct: 611 GDLLLQQAELPLSTEDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHLGPHSPQSVMV 670
Query: 1212 --AFSVEAGPVHTDATLQVTIALEGPLAPLKLVRHK-------KIYVFQGEAAEIRRDQL 1262
AF V+ H L + P+ ++ + ++ V + + +++ L
Sbjct: 671 QLAFHVQDD--HDPPNLSKQHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQLTHFQKNFL 728
Query: 1263 EAAQEAVPPADIVFSVKSPPS---AGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVL 1319
+ ++ +++ + P+ + V L D P +L + F+Q V+ +V
Sbjct: 729 RYIDQDSDDQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSPDTL--IMHFTQAQVNQHKVA 786
Query: 1320 Y-----LHSRPEAWSDAFSLDVASGLGAPLEGVLVELEVLPAAIPLEAQNFSVPEGGSLT 1374
Y L P + ++ A+G P L V + + F++ EGGS
Sbjct: 787 YQPPQKLGIAPRVVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPPEVTNRGFAILEGGSFN 846
Query: 1375 LAPPLLRVSGPYFPTLLGLSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVH 1434
L+ L V+ P + + ++ PQHG LQ +F V + Y H
Sbjct: 847 LSSNELHVTDP-DTDIDQIVFILVRGPQHGHLQYFKRCMVPG-ESFMQADVINGSVSYQH 904
Query: 1435 DGSETLT-DSFVLMANASEMDRQSH-PVAFTVTVLP--VNDQPPILTTNTGL-----QMW 1485
+T T D+F L + D H P+ ++V P N P I ++ L +
Sbjct: 905 GRDQTTTSDTFHLEVS----DGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVL 960
Query: 1486 EGATAPIPAEALRSTDGDSGSEDLVYTI-EQPSNGRVVLRGAPGTEVRSFTQAQLDGGLV 1544
E I + D G L + + + P G +++ G P FTQ L G V
Sbjct: 961 ENKATEITMGVIHGKRKDVGDLMLSFIVKDSPKLGTILVNGLP---TERFTQEDLINGRV 1017
Query: 1545 LFSHRGTLDG------GFRFRLS-DGEHTSPGHFFRVTAQKQVLL--------SLKGSQT 1589
++H G F LS D G+ Q QV + + ++
Sbjct: 1018 AYAHTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVLVGES 1077
Query: 1590 LTVCPGSVQPLSSQTLRASSSAGTDPQLLLYRVVRGPQLGRLFH------AQQDSTGEAL 1643
V G L+ Q L T LL V P G L ++ +G +
Sbjct: 1078 FIVYEGEKNSLTLQHLHV-EDVDTHQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPI 1136
Query: 1644 VNFTQAEVYAGNILYEHEM-----PPEPFWEAHDTLELQLSSPPARDVAATLAVAVSFEA 1698
F+ ++ +I Y + P E + + + + S +V + + + +
Sbjct: 1137 SAFSLRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSP----NVFFPIIILPTNDE 1192
Query: 1699 ACPQRPSHLWKNKGLWVPEGQRARITVAALDASNLLASVPSPQRSEHDVLFQVTQFPSRG 1758
P+ +H +K V EG I L+ ++ A +P +++ FQ+T P G
Sbjct: 1193 Q-PKLFAHEFK-----VLEGMSLVIDTQLLNGAD--ADLP-----PNELHFQLTALPRHG 1239
Query: 1759 ----QLLVSEEPLHAGQPHFLQSQLAAGQLVYAHGGGGTQQDGFHFRAHLQGPAGASVAG 1814
QL +P+H+ L+ A +VY H T++D F S
Sbjct: 1240 RIIQQLATGSQPIHS---FTLKEIQEASTIVYEHDDSETKEDSFE--------VWLSDGK 1288
Query: 1815 PQTSEAFAITVRDVNERPPQPQASVPLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQR 1874
T I V V++ P + L++ +G I+ L D DS + + +
Sbjct: 1289 HTTHRKVPIVVTLVDDETPHLTVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHS 1348
Query: 1875 APHNGFLSLVGGGLGPV-------TRFTQADVDSGRLAFVANG-SSVAGIFQLSMSDGAS 1926
P G L + G V FTQ +++ G + ++ G + I + ++DG +
Sbjct: 1349 GPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGVN 1408
Query: 1927 PPLPMSLAVDI--LPSAIEVQLRAPLEVPQALGRSSLSQQQLRVVSDREEPEAAYRLIQG 1984
V I L S + + + + R +L+ L E + + +
Sbjct: 1409 TLTDHYFYVTIGNLDSVFPEVISKRITLIEG-ARVTLTNNLLTNSDINSSDEHHFSITRA 1467
Query: 1985 PQYGHLL---VGGRPTSAFSQFQIDQGEVVFAFT-NFSSSHDHFRVLALARGVNASAVVN 2040
P GHL G P ++F+Q Q+ ++ + T N D F +
Sbjct: 1468 PSLGHLESSDYAGEPIASFTQLQLASNKISYVHTSNDEKKMDSFEFQVIGELYPVFRTFR 1527
Query: 2041 VTVRALLHVWAGGPWPQGATLRLDPTVLDAGELANRTGSVP----RFRLLEGPRHGRVVR 2096
+ + + + + + D ++ EL P F + + P HG+++
Sbjct: 1528 IFITDVDNKKPILTIHRLTLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKILY 1587
Query: 2097 VPRARTEPGGSQLVEQFTQQDL 2118
GS+ V FT+QDL
Sbjct: 1588 --------NGSRPVTTFTKQDL 1601
Score = 90.9 bits (224), Expect = 1e-17
Identities = 242/1106 (21%), Positives = 411/1106 (37%), Gaps = 221/1106 (19%)
Query: 1172 PRWGQLVRA-GQPATAFSQQD---LLDGAVLYSHNGSLSP-RDTMAFSVEA-GPVHTDAT 1225
P++G+LV A G P D L V Y H + SP RD + VE GP DA
Sbjct: 221 PKYGRLVDAVGAPLPRGKGVDCEAFLRAGVRYQHTATSSPNRDYVPMMVELLGPEGQDAG 280
Query: 1226 ---------LQVTIALEG-----PLAPLKLVRHKKIYVFQGEAAEIRRDQLEAAQEAVPP 1271
Q+ + + G P P + + V + D L A P
Sbjct: 281 SAGVLVREHFQLLVRIRGGAENTPPRP-SFMATMMMEVDPLVLTALTPDALAAEDVESDP 339
Query: 1272 ADIVFSVKSPPS--------AGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLYLHS 1323
D+VF++ + P+ GY+V D+P L PV F+Q+ + ++ Y
Sbjct: 340 GDLVFNILNAPTHPPGHPGQQGYVVST------DDPLGL-PVSFFTQQELRELKIAYQPP 392
Query: 1324 RPEAWSDAF---SLDVASGLGAPLE--GVLVELEVLPAAIPLEAQNFSVP--EGGSLTLA 1376
+ + L+V G GA + +V ++ + +P+ + N + EG S L+
Sbjct: 393 AENSHGERLFQLELEVVDGDGAASDPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSRPLS 452
Query: 1377 PP-LLRVSGPYFPTLLGLSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVHD 1435
+ +S L + + + +HG L P F+ + + Y HD
Sbjct: 453 STHSIPISDK--DNLEEVKMAAVRGLRHGQLVVFGAPAG--CKYFTPADLAAGRVVYQHD 508
Query: 1436 GSETLTDSFVLMANASEMDRQSHPV--AFTVTVLPVNDQPPILTTNTGLQMWEGATAPIP 1493
GS T +D+ + M+ H V F +T+LPV+D+PP++ TNTGL + EG I
Sbjct: 509 GSNTYSDNIIF-----RMEDGHHQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQIS 563
Query: 1494 AEALRSTDGDSGSEDLVYTIE-QPSNG---RVVLRGAPGTE------------------- 1530
L +TD DS + + +E QP G APG+
Sbjct: 564 PFVLSATDIDSEDSTIHFVLENQPLKGNEEEPQWELAPGSSHSGHYLGDLLLQQAELPLS 623
Query: 1531 ------------------VRSFTQAQLDGGLVLFSHRG-----TLDGGFRFRLSDGEHTS 1567
V + Q + G + + H G ++ F + D +H
Sbjct: 624 TEDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHVQD-DHDP 682
Query: 1568 PG----HFFRVTAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASS---------SAGTD 1614
P H F + Q +LS + + PG+ ++ Q + + +D
Sbjct: 683 PNLSKQHIFTIKVQPVDILSPQ------LYPGTTLEMTVQEYQLTHFQKNFLRYIDQDSD 736
Query: 1615 PQLLLYRVVRGP-------QLGRLFHAQQDSTGEALVNFTQAEVYAGNILYEHEMPPEPF 1667
Q L Y ++ P Q+ DS +++FTQA+V + Y+ PP+
Sbjct: 737 DQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQVNQHKVAYQ---PPQKL 793
Query: 1668 WEAHDTLEL--QLSSPPARDVAATLAVAVSFEAACPQRPSHLWKNKGLWVPEGQRARITV 1725
A ++ Q+ V T + F +P + N+G + EG
Sbjct: 794 GIAPRVVQFTYQVEDAAGNSVPGTFTL---FLQPVDNQPPEV-TNRGFAILEG------- 842
Query: 1726 AALDASNLLASVPSPQRSEHDVLFQVTQFPSRGQLLVSEEPLHAGQPHFLQSQLAAGQLV 1785
+ + S+ V P ++F + + P G L + + G+ F+Q+ + G +
Sbjct: 843 GSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKRCMVPGE-SFMQADVINGSVS 901
Query: 1786 YAHG-GGGTQQDGFHFRA-----HLQGPAGASVAGPQTSEAFAITVR-----DVNERPPQ 1834
Y HG T D FH H+ SV + + I++R DV+ +
Sbjct: 902 YQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVLE 961
Query: 1835 PQAS-VPLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTR 1893
+A+ + + + G R + LS + DS P G +++ GL P R
Sbjct: 962 NKATEITMGVIHGKRKDVGDLMLSFIVKDS------------PKLG--TILVNGL-PTER 1006
Query: 1894 FTQADVDSGRLAFVANGSSVA-----GIFQLSMSD-------GASPPLPMSLAVDILP-- 1939
FTQ D+ +GR+A+ V F L +S G S + + V +LP
Sbjct: 1007 FTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVD 1066
Query: 1940 SAIEVQLRAPLEVPQALGRSSLSQQQLRVVS-DREEPEAAYRLIQGPQYGHL-------- 1990
+ L + ++SL+ Q L V D + E + P G+L
Sbjct: 1067 NVGPKVLVGESFIVYEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEKIASAPG 1126
Query: 1991 ---LVGGRPTSAFSQFQIDQGEVVFA---FTNFSSSHDHFRVLALARGVNASAVVNVTV- 2043
G P SAFS I + + D F + G+N S V +
Sbjct: 1127 SKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQEDQF-TFYCSDGINFSPNVFFPII 1185
Query: 2044 ---------RALLHVWAGGPWPQGATLRLDPTVLDAGELANRTGSVPRFRLLEGPRHGRV 2094
+ H + +G +L +D +L+ + A+ + F+L PRHGR+
Sbjct: 1186 ILPTNDEQPKLFAHEF---KVLEGMSLVIDTQLLNGAD-ADLPPNELHFQLTALPRHGRI 1241
Query: 2095 VRVPRARTEPGGSQLVEQFTQQDLED 2120
++ GSQ + FT +++++
Sbjct: 1242 IQQLAT-----GSQPIHSFTLKEIQE 1262
Score = 90.1 bits (222), Expect = 2e-17
Identities = 202/865 (23%), Positives = 324/865 (37%), Gaps = 109/865 (12%)
Query: 421 LPPVFANFTQLLTISPLVVAEGGTAWLE---WRHVQPTLDLMEAELRKSQVLFSVTRGAR 477
+P F F Q + P V G A LE + L + + + Q++F + RG +
Sbjct: 814 VPGTFTLFLQPVDNQPPEVTNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQ 873
Query: 478 HGELELDIPGAQARKMFTLLDVVNRKARFIHDGSE-DTSDQLVLEVS-VTARVPMPSCLR 535
HG L+ + F DV+N + H + TSD LEVS +P+
Sbjct: 874 HGHLQYFKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVHHIPI----- 928
Query: 536 RGQTYLLPIQVNP--VNDPPHIIFPHGSLM----VILEHTQKPLGPEVFQAYDPDSACEG 589
+PI V+P N P I SL+ +LE+ + V D
Sbjct: 929 -----TIPISVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLM 983
Query: 590 LTFQV-----LGT--SSGLPVERRDQPGEPATEFSCRELEAGSLVYVHRGGPA----QDL 638
L+F V LGT +GLP ER F+ +L G + Y H G Q
Sbjct: 984 LSFIVKDSPKLGTILVNGLPTER----------FTQEDLINGRVAYAHTAGEVGFQKQHD 1033
Query: 639 TFRV---SDGLQ-----------ASPPATLKVVAIRPAIQIHRSTGLRLAQGSAMPILPA 684
F + D Q L V + P + + S + +G +
Sbjct: 1034 AFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVLVGES--FIVYEGEKNSLTLQ 1091
Query: 685 NLSVETNAVGQDVSVLFRVTGALQFGELQK--QGAGGVEGAEWWATQAFHQRDVEQGRVR 742
+L VE QD +L VT G L+K G AF RD++ +
Sbjct: 1092 HLHVEDVDTHQD-ELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHIN 1150
Query: 743 YLST-----DPQHHAYDTVENLALEVQVGQEILSNLSFPVTIQRATVWMLRLEPLHTQNT 797
Y+ + +PQ + G N+ FP+ I +L +
Sbjct: 1151 YVQSIHKGVEPQE------DQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVL 1204
Query: 798 QQETLTTAHLEATLEEAGPSPPTFHYEVVQAPRKGN-LQLQGTRLSDGQGFTQDDIQ-AG 855
+ +L +A P H+++ PR G +Q T FT +IQ A
Sbjct: 1205 EGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEIQEAS 1264
Query: 856 RVTYGATARASEAVEDTFRFRVTAPPYFSPLYTFPIHIGGDPDAPVLT-NVLLVVPEGGE 914
+ Y SE ED+F ++ + + + D + P LT N L V +G
Sbjct: 1265 TIVY--EHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKGHS 1322
Query: 915 GVLSADHLFVKSLNS--ASYLYEVMERPRHGRLAW----RG-TQDKTTMVTSFTNEDLLR 967
+++ L L+S S + + P+ G L RG ++ T+ +FT +++ R
Sbjct: 1323 EIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEINR 1382
Query: 968 GRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGVFRVAIQPVNDHAPVQTISRIF 1027
G + Y H E D I F T + D F V I ++ P + IS+
Sbjct: 1383 GLICYIHTGQEGIVDIIKFDVTDGVNTLTD-------HYFYVTIGNLDSVFP-EVISKRI 1434
Query: 1028 HVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIVAVDEPTRPIYRFTQEDLR 1087
+ G R LT + + SD +S + +TR L G + + D PI FTQ L
Sbjct: 1435 TLIEGARVTLTNNLLTNSDINSS-DEHHFSITRAPSL-GHLESSDYAGEPIASFTQLQLA 1492
Query: 1088 KRRVLFVHSGADR---GWIQLQVSDGQHQA-----TALLEVQASEPYLRVANGSSLVVPQ 1139
++ +VH+ D + QV + + +V +P L + L + +
Sbjct: 1493 SNKISYVHTSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTI---HRLTLQK 1549
Query: 1140 GGQGTIDTAVLHLDTNLDIRSGDEVHYHVTAGPRWGQLVRAG-QPATAFSQQDLLDGAVL 1198
I +L L D + + +T P G+++ G +P T F++QDL +
Sbjct: 1550 EDSQLI--TLLELTVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLIS 1607
Query: 1199 YSHNGSLSPRDTMAFSVEAGPVHTD 1223
Y H+GS + D+ + +V G HTD
Sbjct: 1608 YKHDGSETTEDSFSLTVTDG-THTD 1631
Score = 43.9 bits (102), Expect = 0.002
Identities = 43/150 (28%), Positives = 64/150 (42%), Gaps = 17/150 (11%)
Query: 437 LVVAEGGTAWLEWRHVQPTLDLMEAELRKSQVLFSVTRGARHGELELDIPGAQAR-KMFT 495
LV+ EG + L H P D E +V + RG RHG+L + GA A K FT
Sbjct: 441 LVLFEGQSRPLSSTHSIPISDKDNLE----EVKMAAVRGLRHGQLV--VFGAPAGCKYFT 494
Query: 496 LLDVVNRKARFIHDGSEDTSDQLVLEVSVTARVPMPSCLRRGQTYLLPIQVNPVNDPPHI 555
D+ + + HDGS SD ++ + +L P+ + PV+D P +
Sbjct: 495 PADLAAGRVVYQHDGSNTYSDNIIFRMEDG---------HHQVDFLFPLTILPVDDEPPM 545
Query: 556 IFPHGSLMVILEHTQKPLGPEVFQAYDPDS 585
+ + L + E + P V A D DS
Sbjct: 546 VNTNTGLS-LTEGQVVQISPFVLSATDIDS 574
Score = 42.7 bits (99), Expect = 0.004
Identities = 61/237 (25%), Positives = 88/237 (37%), Gaps = 45/237 (18%)
Query: 847 FTQDDIQAGRVTYGATARASE----------------AVEDTFRFRVTAPPYFSPLYTFP 890
FTQ +++ ++ Y A S A D F F VT + L
Sbjct: 377 FTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAASDPFAFMVTVKS-MNTLVPVA 435
Query: 891 IHIGGDPDAPVLTNVLLVVPEGGEGVLSADHLFVKSLNSASYLYEV----MERPRHGRLA 946
H G LV+ EG LS+ H ++ L EV + RHG+L
Sbjct: 436 SHNRG-----------LVLFEGQSRPLSSTHSI--PISDKDNLEEVKMAAVRGLRHGQLV 482
Query: 947 WRGTQDKTTMVTSFTNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGV 1006
G FT DL GR+VYQHD S T D+I F G D +
Sbjct: 483 VFGAPAGCKY---FTPADLAAGRVVYQHDGSNTYSDNIIF-RMEDGHHQVDF-------L 531
Query: 1007 FRVAIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDL 1063
F + I PV+D P+ + + G ++ ++ +D DS + VL + L
Sbjct: 532 FPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPL 588
>gi|169166904 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
sapiens]
Length = 2139
Score = 203 bits (516), Expect = 2e-51
Identities = 256/1044 (24%), Positives = 428/1044 (40%), Gaps = 109/1044 (10%)
Query: 950 TQDKTTMVTSFTNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGVFRV 1009
T T++ FT + + ++ YQ + T Q E D A V G F +
Sbjct: 765 TDSPDTLIMHFTQAQVNQHKVAYQPPQKLGIAPRV-VQFTYQVE---DAAGNSVPGTFTL 820
Query: 1010 AIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIV 1069
+QPV D+ P + +R F + GG L+++++ +D D+ +L R G +
Sbjct: 821 FLQPV-DNQPPEVTNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQ-HGHLQ 878
Query: 1070 AVDEPTRPIYRFTQEDLRKRRVLFVHSGADR----GWIQLQVSDGQHQATALLEVQAS-- 1123
P F Q D+ V + H G D+ L+VSDG H + +
Sbjct: 879 YFKRCMVPGESFMQADVINGSVSYQH-GRDQTTTSDTFHLEVSDGVHHIPITIPISVHPN 937
Query: 1124 ----EPYLRVANGS----SLVVPQGGQGTIDTAVLHLDTNLDIRSGD-EVHYHVTAGPRW 1174
P + + + S S+ V + I V+H D+ GD + + V P+
Sbjct: 938 VANRSPRISLRSSSLLDVSIDVLENKATEITMGVIH-GKRKDV--GDLMLSFIVKDSPKL 994
Query: 1175 GQLVRAGQPATAFSQQDLLDGAVLYSHN----GSLSPRDTMAFS--------VEAGPVHT 1222
G ++ G P F+Q+DL++G V Y+H G D + V +
Sbjct: 995 GTILVNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIE 1054
Query: 1223 DATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEIRRDQLEAAQEAVPPADIVFSVKSPP 1282
+QVT+ + P LV I V++GE + L +++ +V S P
Sbjct: 1055 KVQVQVTVLPVDNVGPKVLVGESFI-VYEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQP 1113
Query: 1283 SAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLY---LHSRPEAWSDAFSLDVASG 1339
++GYL ++ + S P+ +FS + + Y +H E D F+ + G
Sbjct: 1114 ASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDG 1173
Query: 1340 LGAPLEGVLVELEVLPA---AIPLEAQNFSVPEGGSLTLAPPLLRVSGPYFPTLLGLSLQ 1396
+ V + +LP L A F V EG SL + LL + P L Q
Sbjct: 1174 INFS-PNVFFPIIILPTNDEQPKLFAHEFKVLEGMSLVIDTQLLNGADADLPPN-ELHFQ 1231
Query: 1397 VLEPPQHGALQKEDGPQARTLSAFSWRMVEE-QLIRYVHDGSETLTDSF-VLMANASEMD 1454
+ P+HG + ++ ++ + +F+ + ++E I Y HD SET DSF V +++
Sbjct: 1232 LTALPRHGRIIQQLATGSQPIHSFTLKEIQEASTIVYEHDDSETKEDSFEVWLSDGKHTT 1291
Query: 1455 RQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEALRSTDGDSGSEDLVYTIE 1514
+ P+ T+ V+D+ P LT N GL++ +G + I L++TD DS + L + +
Sbjct: 1292 HRKVPIVVTL----VDDETPHLTVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLH 1347
Query: 1515 Q-PSNGRVVLRGAPGTEVR-------SFTQAQLDGGLVLFSHRGT--LDGGFRFRLSDGE 1564
P G + P EVR +FTQ +++ GL+ + H G + +F ++DG
Sbjct: 1348 SGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGV 1407
Query: 1565 HTSPGHFFRVT-AQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASSSAGTDPQLLLYRVV 1623
+T H+F VT + S+ +T+ G+ L++ L S +D + +
Sbjct: 1408 NTLTDHYFYVTIGNLDSVFPEVISKRITLIEGARVTLTNNLLTNSDINSSDEH--HFSIT 1465
Query: 1624 RGPQLGRLFHAQQDSTGEALVNFTQAEVYAGNILYEHEMPPEPFWEAHDTLELQLSSPPA 1683
R P LG L D GE + +FTQ ++ + I Y H E + D+ E Q+
Sbjct: 1466 RAPSLGHL--ESSDYAGEPIASFTQLQLASNKISYVHTSNDE---KKMDSFEFQVIG-EL 1519
Query: 1684 RDVAATLAVAVS-FEAACPQRPSHLWKNKGLWVPEGQRARITVAALDA---SNLLASVPS 1739
V T + ++ + P H R+T+ D+ + L +V
Sbjct: 1520 YPVFRTFRIFITDVDNKKPILTIH---------------RLTLQKEDSQLITLLELTVED 1564
Query: 1740 PQRSEHDVLFQVTQFPSRGQLLVS-EEPLHAGQPHFLQSQLAAGQLVYAHGGGGTQQDGF 1798
+ +LF +TQ P G++L + P+ F + L + Y H G T +D F
Sbjct: 1565 SDTPDDLILFTITQVPMHGKILYNGSRPVTT----FTKQDLNKNLISYKHDGSETTEDSF 1620
Query: 1799 HFRAHLQGPAGASVAGPQTS------EAFAITVRDVNERPPQ----PQASVPLRLTRGSR 1848
G P T+ + + +R ++ R PQ A RL G
Sbjct: 1621 SLTV-TDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHM 1679
Query: 1849 A-PISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQADVDSGRLAFV 1907
I+ L D DS ++Y+V R P +GF+ G G FTQAD+D ++++V
Sbjct: 1680 GFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTRVFTQADIDEMKISYV 1739
Query: 1908 ANGSSVAG--IFQLSMSDGASPPL 1929
N S A IF S+ D L
Sbjct: 1740 LNEGSNASKDIFYFSVEDNGGNKL 1763
Score = 178 bits (452), Expect = 5e-44
Identities = 281/1166 (24%), Positives = 483/1166 (41%), Gaps = 161/1166 (13%)
Query: 956 MVTSFTNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGVFRVAIQPVN 1015
+VT + D++ GRL Y+H + + + +A + D + +F + +QPV+
Sbjct: 641 VVTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHV-QDDHDPPNLSKQHIFTIKVQPVD 699
Query: 1016 DHAPV--------QTIS--RIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKD--- 1062
+P T+ ++ H + R + D SD + + + T D
Sbjct: 700 ILSPQLYPGTTLEMTVQEYQLTHFQKNFLRYIDQD----SDDQNLWYTLLTLPTDTDGNH 755
Query: 1063 -LLFGSIVAVDEPTRPIYRFTQEDLRKRRVLF---VHSGADRGWIQL--QVSDGQHQA-- 1114
+ G IV D P I FTQ + + +V + G +Q QV D +
Sbjct: 756 QVRAGEIVLTDSPDTLIMHFTQAQVNQHKVAYQPPQKLGIAPRVVQFTYQVEDAAGNSVP 815
Query: 1115 -TALLEVQASEPYLRVANGSSLVVPQGGQGTIDTAVLHL-DTNLDIRSGDEVHYHVTAGP 1172
T L +Q + + +GG + + LH+ D + DI D++ + + GP
Sbjct: 816 GTFTLFLQPVDNQPPEVTNRGFAILEGGSFNLSSNELHVTDPDTDI---DQIVFILVRGP 872
Query: 1173 RWGQL---VRAGQPATAFSQQDLLDGAVLYSH-NGSLSPRDTMAFSVEAGPVHTDATLQV 1228
+ G L R P +F Q D+++G+V Y H + DT V G H T+ +
Sbjct: 873 QHGHLQYFKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVHHIPITIPI 932
Query: 1229 T----IALEGPLAPLK--LVRHKKIYVFQGEAAEIRRDQLEAAQEAVPPADIVFSVKSPP 1282
+ +A P L+ + I V + +A EI + ++ V + F VK P
Sbjct: 933 SVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLMLSFIVKDSP 992
Query: 1283 SAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLYLHSRPEA----WSDAFSLDVAS 1338
G +++ P + F+QE + GRV Y H+ E DAFSL ++
Sbjct: 993 KLGTILVNGL-----------PTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSK 1041
Query: 1339 GL------GAPLEGVLVELEVLP----AAIPLEAQNFSVPEG--GSLTLAPPLLRVSGPY 1386
+ +E V V++ VLP L ++F V EG SLTL + +
Sbjct: 1042 DSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVLVGESFIVYEGEKNSLTLQHLHVEDVDTH 1101
Query: 1387 FPTLLGLSLQVLEPPQHGALQK-------EDGPQARTLSAFSWRMVEEQLIRYV---HDG 1436
LL V P G L+K + +SAFS R ++ + I YV H G
Sbjct: 1102 QDELL---CTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHKG 1158
Query: 1437 SETLTDSFVLMANASEMDRQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEA 1496
E D F S+ S V F + +LP ND+ P L + ++ EG + I +
Sbjct: 1159 VEPQEDQFTFY--CSDGINFSPNVFFPIIILPTNDEQPKLFAHE-FKVLEGMSLVIDTQL 1215
Query: 1497 LRSTDGDSGSEDLVYTIEQ-PSNGRVVLRGAPGTE-VRSFTQAQL-DGGLVLFSH--RGT 1551
L D D +L + + P +GR++ + A G++ + SFT ++ + +++ H T
Sbjct: 1216 LNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEIQEASTIVYEHDDSET 1275
Query: 1552 LDGGFRFRLSDGEHTSPGHF-FRVTAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASSS 1610
+ F LSDG+HT+ VT L + L V G + ++++ L+A +
Sbjct: 1276 KEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKGHSEIITNRILKA-TD 1334
Query: 1611 AGTDPQLLLYRVVRGPQLGRLFHAQQDSTGEAL------VNFTQAEVYAGNILYEHEMPP 1664
+D + L + + GPQ G L + GE +NFTQ E+ G I Y H
Sbjct: 1335 LDSDDKSLSFVLHSGPQQG-LLQRLRKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQE 1393
Query: 1665 EPFWEAHDTLELQLSSPPARDVAATLAVAV-SFEAACPQRPSHLWKNKGLWVPEGQRARI 1723
D ++ ++ V + + ++ P+ S K + + EG R +
Sbjct: 1394 ----GIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVIS-----KRITLIEGARVTL 1444
Query: 1724 TVAALDASNLLASVPSPQRSEHDVLFQVTQFPSRGQLLVSEEPLHAGQP--HFLQSQLAA 1781
T +NLL + EH F +T+ PS G L S+ +AG+P F Q QLA+
Sbjct: 1445 T------NNLLTNSDINSSDEHH--FSITRAPSLGHLESSD---YAGEPIASFTQLQLAS 1493
Query: 1782 GQLVYAHGGGGTQQ-DGFHFRAHLQGPAGASVAGP--QTSEAFAITVRDVNERPPQPQAS 1838
++ Y H ++ D F F+ V G F I + DV+ + P
Sbjct: 1494 NKISYVHTSNDEKKMDSFEFQ----------VIGELYPVFRTFRIFITDVDNKKPILTIH 1543
Query: 1839 VPLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQAD 1898
L L + I+ +L+V D D+ I + + + P +G ++ G PVT FT+ D
Sbjct: 1544 -RLTLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHG--KILYNGSRPVTTFTKQD 1600
Query: 1899 VDSGRLAFVANGS-SVAGIFQLSMSDGASPP---LPMSLAVDILPSAIEVQLRA-PLEVP 1953
++ +++ +GS + F L+++DG LP + P + VQ+R+ +P
Sbjct: 1601 LNKNLISYKHDGSETTEDSFSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLP 1660
Query: 1954 Q--------ALGRSSLSQQQLRVVS------DREEPE--AAYRLIQGPQYGHLL---VGG 1994
Q AL R + S D++ P Y++ +GP++G ++ +G
Sbjct: 1661 QITTNRGAPALKRLHTGHMGFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGN 1720
Query: 1995 RPTSAFSQFQIDQGEVVFAFTNFSSS 2020
+ T F+Q ID+ ++ + S++
Sbjct: 1721 QSTRVFTQADIDEMKISYVLNEGSNA 1746
Score = 129 bits (323), Expect = 4e-29
Identities = 204/908 (22%), Positives = 368/908 (40%), Gaps = 111/908 (12%)
Query: 825 VVQAPRKGNLQLQGTRLSDGQGFTQDDIQAGRVTYGATARASEAVEDTFRFRVTAPPYFS 884
+V+ P+ G+LQ + G+ F Q D+ G V+Y R DTF V+ +
Sbjct: 868 LVRGPQHGHLQYFKRCMVPGESFMQADVINGSVSY-QHGRDQTTTSDTFHLEVSDGVHHI 926
Query: 885 PLYTFPIHI-----GGDPDAPVLTNVLLVVP------EGGEGVLSADHLFVKSLNSASYL 933
P+ T PI + P + ++ LL V + E + H K +
Sbjct: 927 PI-TIPISVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLMLS 985
Query: 934 YEVMERPRHGRLAWRGTQDKTTMVTSFTNEDLLRGRLVYQHDDSET----TEDDIPFVAT 989
+ V + P+ G + G + FT EDL+ GR+ Y H E D + +
Sbjct: 986 FIVKDSPKLGTILVNGLPTE-----RFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILS 1040
Query: 990 RQGES--SGDMAWEEVRGVFRVAIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDA 1047
+ G+ E+V+ +V + PV++ P + F V G + LT + D
Sbjct: 1041 KDSYQWVVGNSIIEKVQ--VQVTVLPVDNVGPKVLVGESFIVYEGEKNSLTLQHLHVEDV 1098
Query: 1048 DSGFADAQLVLTRKDLLFGSIVAV--------DEPTRPIYRFTQEDLRKRRVLFV---HS 1096
D+ D L G + + + PI F+ D++ R + +V H
Sbjct: 1099 DT-HQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHK 1157
Query: 1097 GAD--RGWIQLQVSDGQHQA------TALLEVQASEPYL-----RVANGSSLVVPQGGQG 1143
G + SDG + + +L +P L +V G SLV
Sbjct: 1158 GVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVLEGMSLV------- 1210
Query: 1144 TIDTAVLH-LDTNLDIRSGDEVHYHVTAGPRWG----QLVRAGQPATAFSQQDLLDGA-V 1197
IDT +L+ D +L +E+H+ +TA PR G QL QP +F+ +++ + + +
Sbjct: 1211 -IDTQLLNGADADL---PPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEIQEASTI 1266
Query: 1198 LYSHNGSLSPRDTMAFSVEAGPVHTDATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEI 1257
+Y H+ S + D+ + G T + + + L P L + + V +G + I
Sbjct: 1267 VYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETP-HLTVNNGLKVEKGHSEII 1325
Query: 1258 RRDQLEAAQEAVPPADIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGR 1317
L+A + F + S P G L + R + +L +F+Q+ ++ G
Sbjct: 1326 TNRILKATDLDSDDKSLSFVLHSGPQQGLLQRL-RKPRGEVRNNLTLGMNFTQDEINRGL 1384
Query: 1318 VLYLHSRPEAWSDAFSLDVASGLGAPLEGVL-VELEVLPAAIP-LEAQNFSVPEGGSLTL 1375
+ Y+H+ E D DV G+ + V + L + P + ++ ++ EG +TL
Sbjct: 1385 ICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVISKRITLIEGARVTL 1444
Query: 1376 APPLLRVSGPYFPTLLGLSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVH- 1434
LL S + + P G L+ D +++F+ + I YVH
Sbjct: 1445 TNNLLTNSD--INSSDEHHFSITRAPSLGHLESSD-YAGEPIASFTQLQLASNKISYVHT 1501
Query: 1435 DGSETLTDSFVLMANASEMDRQSHPV--AFTVTVLPVNDQPPILTTNTGLQMWEGATAPI 1492
E DSF ++ + +PV F + + V+++ PILT + L + + + I
Sbjct: 1502 SNDEKKMDSFEF-----QVIGELYPVFRTFRIFITDVDNKKPILTIHR-LTLQKEDSQLI 1555
Query: 1493 PAEALRSTDGDSGSEDLVYTIEQ-PSNGRVVLRGAPGTEVRSFTQAQLDGGLVLFSHRG- 1550
L D D+ + +++TI Q P +G+++ G+ V +FT+ L+ L+ + H G
Sbjct: 1556 TLLELTVEDSDTPDDLILFTITQVPMHGKILYNGS--RPVTTFTKQDLNKNLISYKHDGS 1613
Query: 1551 -TLDGGFRFRLSDGEHTS----PGHFFRVTAQKQVLLSLKGSQT----LTVCPGSVQ--- 1598
T + F ++DG HT P + + + ++ +T G+
Sbjct: 1614 ETTEDSFSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKR 1673
Query: 1599 --------PLSSQTLRASSSAGTDPQLLLYRVVRGPQLGRLFHAQQDSTGEALVNFTQAE 1650
++S++L+A + +LL Y+V RGP+ G F + ++ FTQA+
Sbjct: 1674 LHTGHMGFLITSKSLKAEDQ-DSPHRLLKYKVTRGPEHG--FIIKTGLGNQSTRVFTQAD 1730
Query: 1651 VYAGNILY 1658
+ I Y
Sbjct: 1731 IDEMKISY 1738
Score = 116 bits (290), Expect = 3e-25
Identities = 213/973 (21%), Positives = 374/973 (38%), Gaps = 117/973 (12%)
Query: 546 VNPVNDPPHIIFPHGSLMVILEHTQKPLGPEVFQAYDPDSACEGLTFQVLGTSSGLPVER 605
+ PV++ P + G ILE L DPD+ + + F ++ ++
Sbjct: 822 LQPVDNQPPEVTNRG--FAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQY 879
Query: 606 RDQPGEPATEFSCRELEAGSLVYVH-RGGPAQDLTFR--VSDGLQASP---PATL--KVV 657
+ P F ++ GS+ Y H R TF VSDG+ P P ++ V
Sbjct: 880 FKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNVA 939
Query: 658 AIRPAIQIHRSTGLRLA----QGSAMPILPANLSVETNAVGQDVSVLFRVTGALQFGELQ 713
P I + S+ L ++ + A I + + VG D+ + F V + + G +
Sbjct: 940 NRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVG-DLMLSFIVKDSPKLGTIL 998
Query: 714 KQGAGGVEGAEWWATQAFHQRDVEQGRVRYLST------DPQHHAYDTV-ENLALEVQVG 766
G T+ F Q D+ GRV Y T QH A+ + + + VG
Sbjct: 999 VNGL---------PTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSKDSYQWVVG 1049
Query: 767 QEILSNLSFPVT---IQRATVWMLRLEPLHTQNTQQETLTTAHLEATLEEAGPSPPTFHY 823
I+ + VT + +L E ++ +LT HL +E+
Sbjct: 1050 NSIIEKVQVQVTVLPVDNVGPKVLVGESFIVYEGEKNSLTLQHLH--VEDVDTHQDELLC 1107
Query: 824 EVVQAPRKGNLQ----LQGTRLSDG----QGFTQDDIQAGRVTY-GATARASEAVEDTFR 874
V P G L+ G+++S F+ DIQ + Y + + E ED F
Sbjct: 1108 TVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQEDQFT 1167
Query: 875 FRVTAPPYFSPLYTFPIHI-GGDPDAPVLTNVLLVVPEGGEGVLSADHL--FVKSLNSAS 931
F + FSP FPI I + + P L V EG V+ L L
Sbjct: 1168 FYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVLEGMSLVIDTQLLNGADADLPPNE 1227
Query: 932 YLYEVMERPRHGRLAWR---GTQDKTTMVTSFTNEDLLR-GRLVYQHDDSETTEDDIPFV 987
+++ PRHGR+ + G+Q + SFT +++ +VY+HDDSET ED V
Sbjct: 1228 LHFQLTALPRHGRIIQQLATGSQP----IHSFTLKEIQEASTIVYEHDDSETKEDSFE-V 1282
Query: 988 ATRQGESSGDMAWEEVRGVFRVAIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDA 1047
G+ + + + V+D P T++ V +G ++T + +D
Sbjct: 1283 WLSDGKHT-------THRKVPIVVTLVDDETPHLTVNNGLKVEKGHSEIITNRILKATDL 1335
Query: 1048 DSGFADAQLVLTRKDLLFGSIVAVDEPTRPI-------YRFTQEDLRKRRVLFVHSGADR 1100
DS VL G + + +P + FTQ+++ + + ++H+G +
Sbjct: 1336 DSDDKSLSFVL-HSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQEG 1394
Query: 1101 --GWIQLQVSDGQHQAT---ALLEVQASEPYLRVANGSSLVVPQGGQGTIDTAVLHLDTN 1155
I+ V+DG + T + + + + + +G + T+ +L TN
Sbjct: 1395 IVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVISKRITLIEGARVTLTNNLL---TN 1451
Query: 1156 LDIRSGDEVHYHVTAGPRWGQLVR---AGQPATAFSQQDLLDGAVLYSHNGSLSPR-DTM 1211
DI S DE H+ +T P G L AG+P +F+Q L + Y H + + D+
Sbjct: 1452 SDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQLQLASNKISYVHTSNDEKKMDSF 1511
Query: 1212 AFSVEAGPVHTDATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEIRRDQLEAAQEAVPP 1271
F V T ++ I P+ + ++ + + ++ I +L P
Sbjct: 1512 EFQVIGELYPVFRTFRIFITDVDNKKPILTIH--RLTLQKEDSQLITLLELTVEDSDTPD 1569
Query: 1272 ADIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLYLHSRPEAWSDA 1331
I+F++ P G ++ PV +F+++ ++ + Y H E D+
Sbjct: 1570 DLILFTITQVPMHGKILY----------NGSRPVTTFTKQDLNKNLISYKHDGSETTEDS 1619
Query: 1332 FSLDVASGLGAPL----EGVLVELEVLPAAIPLEAQNFSVPEGGSLTLAPPLLRVSGPYF 1387
FSL V G + L + + + + + +P+ + AP L R+ +
Sbjct: 1620 FSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHM 1679
Query: 1388 PTLLG---------------LSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRY 1432
L+ L +V P+HG + K G ++ F+ ++E I Y
Sbjct: 1680 GFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIK-TGLGNQSTRVFTQADIDEMKISY 1738
Query: 1433 V-HDGSETLTDSF 1444
V ++GS D F
Sbjct: 1739 VLNEGSNASKDIF 1751
Score = 103 bits (256), Expect = 3e-21
Identities = 157/711 (22%), Positives = 286/711 (40%), Gaps = 112/711 (15%)
Query: 1400 PPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVHDGSETLTDS-FVLMANASEMD-RQS 1457
P Q G + D P +S F+ + + E I Y + + F L + D S
Sbjct: 357 PGQQGYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAAS 416
Query: 1458 HPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPA-EALRSTDGDSGSEDLVYTIEQP 1516
P AF VTV +N P+ + N GL ++EG + P+ + ++ +D D+ E + +
Sbjct: 417 DPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSSTHSIPISDKDNLEEVKMAAVRGL 476
Query: 1517 SNGRVVLRGAPGTEVRSFTQAQLDGGLVLFSHRG--TLDGGFRFRLSDGEHTS----PGH 1570
+G++V+ GAP + FT A L G V++ H G T FR+ DG H P
Sbjct: 477 RHGQLVVFGAPAG-CKYFTPADLAAGRVVYQHDGSNTYSDNIIFRMEDGHHQVDFLFPLT 535
Query: 1571 FFRVTAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASSSAGTDPQL---LLYRVVRG-- 1625
V + ++ + G L++ G V +S L A+ D + L + ++G
Sbjct: 536 ILPVDDEPPMVNTNTG---LSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPLKGNE 592
Query: 1626 --PQ-------------LGRLFHAQQD---STGE--------------ALVNFTQAEVYA 1653
PQ LG L Q + ST + + + Q ++
Sbjct: 593 EEPQWELAPGSSHSGHYLGDLLLQQAELPLSTEDEDWHYMEKEGLYEKVVTEWLQRDIME 652
Query: 1654 GNILYEHEMPPEP----------FWEAHDTLELQ------LSSPPARDVAATLAVAVSFE 1697
G + Y H P P + HD L + P ++ L + E
Sbjct: 653 GRLFYRHLGPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDILSPQLYPGTTLE 712
Query: 1698 AACPQ-RPSHLWKNKGLWVPEGQRARITVAALDASNL---LASVPSPQRSEHDVLFQVTQ 1753
+ + +H KN ++ + D NL L ++P+ H V
Sbjct: 713 MTVQEYQLTHFQKNFLRYIDQDS---------DDQNLWYTLLTLPTDTDGNHQV------ 757
Query: 1754 FPSRGQLLVSEEPLHAGQPHFLQSQLAAGQLVYAHGGG-GTQQDGFHFRAHLQGPAGASV 1812
G++++++ P HF Q+Q+ ++ Y G F ++ AG SV
Sbjct: 758 --RAGEIVLTDSP-DTLIMHFTQAQVNQHKVAYQPPQKLGIAPRVVQFTYQVEDAAGNSV 814
Query: 1813 AGPQTSEAFAITVRDVNERPPQPQASVPLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEV 1872
G F + ++ V+ +PP+ + + G +S +L V DPD+ +I + +
Sbjct: 815 PG-----TFTLFLQPVDNQPPEV-TNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFIL 868
Query: 1873 QRAPHNGFLSLVGGGLGPVTRFTQADVDSGRLAFV--ANGSSVAGIFQLSMSDGASPPLP 1930
R P +G L + P F QADV +G +++ + ++ + F L +SDG +P
Sbjct: 869 VRGPQHGHLQYFKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVH-HIP 927
Query: 1931 MSLAVDILPSA------IEVQLRAPLEVPQALGRSSLSQQQLRVVSDREEPEA----AYR 1980
+++ + + P+ I ++ + L+V + + ++ + V+ + + ++
Sbjct: 928 ITIPISVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLMLSFI 987
Query: 1981 LIQGPQYGHLLVGGRPTSAFSQFQIDQGEVVFAFT----NFSSSHDHFRVL 2027
+ P+ G +LV G PT F+Q + G V +A T F HD F ++
Sbjct: 988 VKDSPKLGTILVNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLI 1038
Score = 102 bits (253), Expect = 6e-21
Identities = 216/981 (22%), Positives = 375/981 (38%), Gaps = 175/981 (17%)
Query: 1242 VRHKKIYVFQGEAAEIRRDQLEAAQEAVPPADIVFSVKSPPSAGYLVMVSRGALADEPPS 1301
V ++ + +G + + ++L IVF + P G+L R
Sbjct: 832 VTNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKR--------C 883
Query: 1302 LDPVQSFSQEAVDTGRVLYLHSRPEAW-SDAFSLDVASGLGAPLEGVLVELEVLPAAIPL 1360
+ P +SF Q V G V Y H R + SD F L+V+ G+ +P IP+
Sbjct: 884 MVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGV-----------HHIPITIPI 932
Query: 1361 EAQNFSVPEGGSLTLAPPLLRVSGPYFPTLLGLSLQVLEPPQ--------HGALQK---- 1408
++L +LL +S+ VLE HG +
Sbjct: 933 SVHPNVANRSPRISLRSS----------SLLDVSIDVLENKATEITMGVIHGKRKDVGDL 982
Query: 1409 ------EDGPQARTLSAFSW---RMVEEQLIR----YVHDGSET----LTDSFVLMANAS 1451
+D P+ T+ R +E LI Y H E D+F L+ +
Sbjct: 983 MLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSKD 1042
Query: 1452 EM-----DRQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEALRSTDGDSGS 1506
+ V VTVLPV++ P + ++EG + + L D D+
Sbjct: 1043 SYQWVVGNSIIEKVQVQVTVLPVDNVGPKVLVGESFIVYEGEKNSLTLQHLHVEDVDTHQ 1102
Query: 1507 EDLVYTI-EQPSNGRVV-LRGAPGTE-------VRSFTQAQLDG---GLVLFSHRGT--L 1552
++L+ T+ QP++G + + APG++ + +F+ + V H+G
Sbjct: 1103 DELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQ 1162
Query: 1553 DGGFRFRLSDGEHTSPGHFFRV----TAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRAS 1608
+ F F SDG + SP FF + T +Q L + V G + +Q L +
Sbjct: 1163 EDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLF---AHEFKVLEGMSLVIDTQLLNGA 1219
Query: 1609 SSAGTDPQLLLYRVVRGPQLGRLFHAQQDSTG-EALVNFTQAEVY-AGNILYEHEMPPEP 1666
A P L +++ P+ GR+ QQ +TG + + +FT E+ A I+YEH+
Sbjct: 1220 D-ADLPPNELHFQLTALPRHGRII--QQLATGSQPIHSFTLKEIQEASTIVYEHDDSETK 1276
Query: 1667 FWEAHDTLELQLSSPPARDVAATLAVAVSFEAACPQRPSHLWKNKGLWVPEGQRARITVA 1726
D+ E+ LS V + P HL N GL V +G IT
Sbjct: 1277 ----EDSFEVWLSDGKHTTHRKVPIVVTLVDDETP----HLTVNNGLKVEKGHSEIITNR 1328
Query: 1727 ALDASNLLASVPSPQRSEHDVLFQVTQFPSRGQLLVSEEP-------LHAGQPHFLQSQL 1779
L A++L + + F + P +G L +P L G +F Q ++
Sbjct: 1329 ILKATDL-------DSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGM-NFTQDEI 1380
Query: 1780 AAGQLVYAHGGGGTQQDGFHFRAHLQGPAGASVAGPQTSEAFAITVRDVNERPPQPQASV 1839
G + Y H G Q+G G + T F +T+ +++ P+ S
Sbjct: 1381 NRGLICYIHTG----QEGIVDIIKFDVTDGVNTL---TDHYFYVTIGNLDSVFPEV-ISK 1432
Query: 1840 PLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQADV 1899
+ L G+R ++ L+ D +S+ E + + RAP G L P+ FTQ +
Sbjct: 1433 RITLIEGARVTLTNNLLTNSDINSSD-EHHFSITRAPSLGHLESSDYAGEPIASFTQLQL 1491
Query: 1900 DSGRLAFV--ANGSSVAGIFQLSMSDGASPPLPMSLAVDILPSAIEVQLRAPLEVPQALG 1957
S ++++V +N F+ + G P+ + + I +V + P+ L
Sbjct: 1492 ASNKISYVHTSNDEKKMDSFEFQVI-GELYPVFRTFRIFI----TDVDNKKPILTIHRLT 1546
Query: 1958 RSSLSQQQLRV----VSDREEPE--AAYRLIQGPQYGHLLV-GGRPTSAFSQFQIDQG-- 2008
Q + + V D + P+ + + Q P +G +L G RP + F++ +++
Sbjct: 1547 LQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLI 1606
Query: 2009 ----------EVVFAFTNFSSSHDHFRVLA-LARGVNASAVVNVTVRALLHVWAGGPWPQ 2057
E F+ T +H F VL A + V+ V +R+L PQ
Sbjct: 1607 SYKHDGSETTEDSFSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSL-----DNRLPQ 1661
Query: 2058 GATLRLDPTV--LDAGELA-------------NRTGSVPRFRLLEGPRHGRVVRVPRART 2102
T R P + L G + + + ++++ GP HG +++
Sbjct: 1662 ITTNRGAPALKRLHTGHMGFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGL--- 1718
Query: 2103 EPGGSQLVEQFTQQDLEDGRL 2123
G+Q FTQ D+++ ++
Sbjct: 1719 ---GNQSTRVFTQADIDEMKI 1736
Score = 101 bits (252), Expect = 7e-21
Identities = 162/699 (23%), Positives = 282/699 (40%), Gaps = 64/699 (9%)
Query: 430 QLLTISPLVVAEGGTAWLEWRHVQPTLDLMEAELRKSQVLFSVTRGARHGELELDIPGAQ 489
++L +V EG L +H L + + + + ++L +VT G LE I A
Sbjct: 1071 KVLVGESFIVYEGEKNSLTLQH----LHVEDVDTHQDELLCTVTSQPASGYLE-KIASAP 1125
Query: 490 ARKM---------FTLLDVVNRKARF---IHDGSEDTSDQLVLEVSVTARVPMPSCLRRG 537
KM F+L D+ R + IH G E DQ S +
Sbjct: 1126 GSKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQEDQFTFYCS--------DGINFS 1177
Query: 538 QTYLLPIQVNPVNDPPHIIFPHGSLMVILEHTQKPLGPEVFQAYDPDSACEGLTFQVLGT 597
PI + P ND +F H +LE + ++ D D L FQ+
Sbjct: 1178 PNVFFPIIILPTNDEQPKLFAHE--FKVLEGMSLVIDTQLLNGADADLPPNELHFQLTAL 1235
Query: 598 SS-GLPVERRDQPGEPATEFSCREL-EAGSLVYVHRGGPAQDLTFRV--SDGLQASPPAT 653
G +++ +P F+ +E+ EA ++VY H ++ +F V SDG +
Sbjct: 1236 PRHGRIIQQLATGSQPIHSFTLKEIQEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKV 1295
Query: 654 LKVVAIRPAIQIHRST--GLRLAQGSAMPILPANLSVETNAVGQDVSVLFRVTGALQFGE 711
VV + H + GL++ +G + I+ + T+ D S+ F + Q G
Sbjct: 1296 PIVVTLVDDETPHLTVNNGLKVEKGHS-EIITNRILKATDLDSDDKSLSFVLHSGPQQGL 1354
Query: 712 LQK-QGAGGVEGAEWWATQAFHQRDVEQGRVRYLSTDPQHHAYDTVENLALEVQVGQEIL 770
LQ+ + G F Q ++ +G + Y+ T + V+ + +V G L
Sbjct: 1355 LQRLRKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQE----GIVDIIKFDVTDGVNTL 1410
Query: 771 SNLSFPVTIQRATVWMLRLEPLHTQNTQQETLTTAHLEATLEEAGPSPPTFHYEVVQAPR 830
++ F VTI + + +T + T + S H+ + +AP
Sbjct: 1411 TDHYFYVTIGNLDSVFPEVISKRITLIEGARVTLTNNLLTNSDINSSDE-HHFSITRAPS 1469
Query: 831 KGNLQLQGTRLSDGQGFTQDDIQAGRVTYGATARASEAVEDTFRFRVTAPPYFSPLY-TF 889
G+L+ FTQ + + +++Y T+ E D+F F+V Y P++ TF
Sbjct: 1470 LGHLESSDYAGEPIASFTQLQLASNKISYVHTSN-DEKKMDSFEFQVIGELY--PVFRTF 1526
Query: 890 PIHIGG-DPDAPVLTNVLLVVPEGGEGVLSADHLFVKSLNSAS--YLYEVMERPRHGRLA 946
I I D P+LT L + + +++ L V+ ++ L+ + + P HG++
Sbjct: 1527 RIFITDVDNKKPILTIHRLTLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKIL 1586
Query: 947 WRGTQDKTTMVTSFTNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESS----GDMAWEE 1002
+ G++ VT+FT +DL + + Y+HD SETTED T + D A
Sbjct: 1587 YNGSRP----VTTFTKQDLNKNLISYKHDGSETTEDSFSLTVTDGTHTDFYVLPDTALAT 1642
Query: 1003 VR-GVFRVAIQPVNDHAPVQTISR------IFHVARGGRRLLTTDDVAFSDADSGFADAQ 1055
+ V RV I+ +++ P T +R H G L+T+ + D DS +
Sbjct: 1643 HKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHMG-FLITSKSLKAEDQDSPHRLLK 1701
Query: 1056 LVLTRKDLLFGSIVAVDEPTRPIYRFTQEDLRKRRVLFV 1094
+TR G I+ + FTQ D+ + ++ +V
Sbjct: 1702 YKVTRGP-EHGFIIKTGLGNQSTRVFTQADIDEMKISYV 1739
Score = 97.4 bits (241), Expect = 1e-19
Identities = 275/1342 (20%), Positives = 484/1342 (36%), Gaps = 205/1342 (15%)
Query: 917 LSADHLFVKSLNS--ASYLYEVMERPRH--GRLAWRG----TQDKTTM-VTSFTNEDLLR 967
L+ D L + + S ++ ++ P H G +G T D + V+ FT ++L
Sbjct: 325 LTPDALAAEDVESDPGDLVFNILNAPTHPPGHPGQQGYVVSTDDPLGLPVSFFTQQELRE 384
Query: 968 GRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRG--------VFRVAIQPVNDHAP 1019
++ YQ P GE + E V G F V ++ +N P
Sbjct: 385 LKIAYQ-----------PPAENSHGERLFQLELEVVDGDGAASDPFAFMVTVKSMNTLVP 433
Query: 1020 VQTISRIFHVARG-GRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIVAVDEPTRPI 1078
V + +R + G R L +T + SD D+ + ++ R L G +V P
Sbjct: 434 VASHNRGLVLFEGQSRPLSSTHSIPISDKDN-LEEVKMAAVR-GLRHGQLVVFGAPAGCK 491
Query: 1079 YRFTQEDLRKRRVLFVHSGADR--GWIQLQVSDGQHQATAL-----LEVQASEPYLRVAN 1131
Y FT DL RV++ H G++ I ++ DG HQ L L V P +
Sbjct: 492 Y-FTPADLAAGRVVYQHDGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVDDEPPMVNTNT 550
Query: 1132 GSSLVVPQGGQ-----------GTIDTAVLHLDTNLDIRSGDEV-------------HYH 1167
G SL Q Q + D+ + + N ++ +E HY
Sbjct: 551 GLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPLKGNEEEPQWELAPGSSHSGHYL 610
Query: 1168 ------------VTAGPRWGQLVRAG---QPATAFSQQDLLDGAVLYSHNGSLSPRDTM- 1211
T W + + G + T + Q+D+++G + Y H G SP+ M
Sbjct: 611 GDLLLQQAELPLSTEDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHLGPHSPQSVMV 670
Query: 1212 --AFSVEAGPVHTDATLQVTIALEGPLAPLKLVRHK-------KIYVFQGEAAEIRRDQL 1262
AF V+ H L + P+ ++ + ++ V + + +++ L
Sbjct: 671 QLAFHVQDD--HDPPNLSKQHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQLTHFQKNFL 728
Query: 1263 EAAQEAVPPADIVFSVKSPPS---AGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVL 1319
+ ++ +++ + P+ + V L D P +L + F+Q V+ +V
Sbjct: 729 RYIDQDSDDQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSPDTL--IMHFTQAQVNQHKVA 786
Query: 1320 Y-----LHSRPEAWSDAFSLDVASGLGAPLEGVLVELEVLPAAIPLEAQNFSVPEGGSLT 1374
Y L P + ++ A+G P L V + + F++ EGGS
Sbjct: 787 YQPPQKLGIAPRVVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPPEVTNRGFAILEGGSFN 846
Query: 1375 LAPPLLRVSGPYFPTLLGLSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVH 1434
L+ L V+ P + + ++ PQHG LQ +F V + Y H
Sbjct: 847 LSSNELHVTDP-DTDIDQIVFILVRGPQHGHLQYFKRCMVPG-ESFMQADVINGSVSYQH 904
Query: 1435 DGSETLT-DSFVLMANASEMDRQSH-PVAFTVTVLP--VNDQPPILTTNTGL-----QMW 1485
+T T D+F L + D H P+ ++V P N P I ++ L +
Sbjct: 905 GRDQTTTSDTFHLEVS----DGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVL 960
Query: 1486 EGATAPIPAEALRSTDGDSGSEDLVYTI-EQPSNGRVVLRGAPGTEVRSFTQAQLDGGLV 1544
E I + D G L + + + P G +++ G P FTQ L G V
Sbjct: 961 ENKATEITMGVIHGKRKDVGDLMLSFIVKDSPKLGTILVNGLP---TERFTQEDLINGRV 1017
Query: 1545 LFSHRGTLDG------GFRFRLS-DGEHTSPGHFFRVTAQKQVLL--------SLKGSQT 1589
++H G F LS D G+ Q QV + + ++
Sbjct: 1018 AYAHTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVLVGES 1077
Query: 1590 LTVCPGSVQPLSSQTLRASSSAGTDPQLLLYRVVRGPQLGRLFH------AQQDSTGEAL 1643
V G L+ Q L T LL V P G L ++ +G +
Sbjct: 1078 FIVYEGEKNSLTLQHLHV-EDVDTHQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPI 1136
Query: 1644 VNFTQAEVYAGNILYEHEM-----PPEPFWEAHDTLELQLSSPPARDVAATLAVAVSFEA 1698
F+ ++ +I Y + P E + + + + S +V + + + +
Sbjct: 1137 SAFSLRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSP----NVFFPIIILPTNDE 1192
Query: 1699 ACPQRPSHLWKNKGLWVPEGQRARITVAALDASNLLASVPSPQRSEHDVLFQVTQFPSRG 1758
P+ +H +K V EG I L+ ++ A +P +++ FQ+T P G
Sbjct: 1193 Q-PKLFAHEFK-----VLEGMSLVIDTQLLNGAD--ADLP-----PNELHFQLTALPRHG 1239
Query: 1759 ----QLLVSEEPLHAGQPHFLQSQLAAGQLVYAHGGGGTQQDGFHFRAHLQGPAGASVAG 1814
QL +P+H+ L+ A +VY H T++D F S
Sbjct: 1240 RIIQQLATGSQPIHS---FTLKEIQEASTIVYEHDDSETKEDSFE--------VWLSDGK 1288
Query: 1815 PQTSEAFAITVRDVNERPPQPQASVPLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQR 1874
T I V V++ P + L++ +G I+ L D DS + + +
Sbjct: 1289 HTTHRKVPIVVTLVDDETPHLTVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHS 1348
Query: 1875 APHNGFLSLVGGGLGPV-------TRFTQADVDSGRLAFVANG-SSVAGIFQLSMSDGAS 1926
P G L + G V FTQ +++ G + ++ G + I + ++DG +
Sbjct: 1349 GPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGVN 1408
Query: 1927 PPLPMSLAVDI--LPSAIEVQLRAPLEVPQALGRSSLSQQQLRVVSDREEPEAAYRLIQG 1984
V I L S + + + + R +L+ L E + + +
Sbjct: 1409 TLTDHYFYVTIGNLDSVFPEVISKRITLIEG-ARVTLTNNLLTNSDINSSDEHHFSITRA 1467
Query: 1985 PQYGHLL---VGGRPTSAFSQFQIDQGEVVFAFT-NFSSSHDHFRVLALARGVNASAVVN 2040
P GHL G P ++F+Q Q+ ++ + T N D F +
Sbjct: 1468 PSLGHLESSDYAGEPIASFTQLQLASNKISYVHTSNDEKKMDSFEFQVIGELYPVFRTFR 1527
Query: 2041 VTVRALLHVWAGGPWPQGATLRLDPTVLDAGELANRTGSVP----RFRLLEGPRHGRVVR 2096
+ + + + + + D ++ EL P F + + P HG+++
Sbjct: 1528 IFITDVDNKKPILTIHRLTLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKILY 1587
Query: 2097 VPRARTEPGGSQLVEQFTQQDL 2118
GS+ V FT+QDL
Sbjct: 1588 --------NGSRPVTTFTKQDL 1601
Score = 90.9 bits (224), Expect = 1e-17
Identities = 242/1106 (21%), Positives = 411/1106 (37%), Gaps = 221/1106 (19%)
Query: 1172 PRWGQLVRA-GQPATAFSQQD---LLDGAVLYSHNGSLSP-RDTMAFSVEA-GPVHTDAT 1225
P++G+LV A G P D L V Y H + SP RD + VE GP DA
Sbjct: 221 PKYGRLVDAVGAPLPRGKGVDCEAFLRAGVRYQHTATSSPNRDYVPMMVELLGPEGQDAG 280
Query: 1226 ---------LQVTIALEG-----PLAPLKLVRHKKIYVFQGEAAEIRRDQLEAAQEAVPP 1271
Q+ + + G P P + + V + D L A P
Sbjct: 281 SAGVLVREHFQLLVRIRGGAENTPPRP-SFMATMMMEVDPLVLTALTPDALAAEDVESDP 339
Query: 1272 ADIVFSVKSPPS--------AGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLYLHS 1323
D+VF++ + P+ GY+V D+P L PV F+Q+ + ++ Y
Sbjct: 340 GDLVFNILNAPTHPPGHPGQQGYVVST------DDPLGL-PVSFFTQQELRELKIAYQPP 392
Query: 1324 RPEAWSDAF---SLDVASGLGAPLE--GVLVELEVLPAAIPLEAQNFSVP--EGGSLTLA 1376
+ + L+V G GA + +V ++ + +P+ + N + EG S L+
Sbjct: 393 AENSHGERLFQLELEVVDGDGAASDPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSRPLS 452
Query: 1377 PP-LLRVSGPYFPTLLGLSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVHD 1435
+ +S L + + + +HG L P F+ + + Y HD
Sbjct: 453 STHSIPISDK--DNLEEVKMAAVRGLRHGQLVVFGAPAG--CKYFTPADLAAGRVVYQHD 508
Query: 1436 GSETLTDSFVLMANASEMDRQSHPV--AFTVTVLPVNDQPPILTTNTGLQMWEGATAPIP 1493
GS T +D+ + M+ H V F +T+LPV+D+PP++ TNTGL + EG I
Sbjct: 509 GSNTYSDNIIF-----RMEDGHHQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQIS 563
Query: 1494 AEALRSTDGDSGSEDLVYTIE-QPSNG---RVVLRGAPGTE------------------- 1530
L +TD DS + + +E QP G APG+
Sbjct: 564 PFVLSATDIDSEDSTIHFVLENQPLKGNEEEPQWELAPGSSHSGHYLGDLLLQQAELPLS 623
Query: 1531 ------------------VRSFTQAQLDGGLVLFSHRG-----TLDGGFRFRLSDGEHTS 1567
V + Q + G + + H G ++ F + D +H
Sbjct: 624 TEDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHVQD-DHDP 682
Query: 1568 PG----HFFRVTAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASS---------SAGTD 1614
P H F + Q +LS + + PG+ ++ Q + + +D
Sbjct: 683 PNLSKQHIFTIKVQPVDILSPQ------LYPGTTLEMTVQEYQLTHFQKNFLRYIDQDSD 736
Query: 1615 PQLLLYRVVRGP-------QLGRLFHAQQDSTGEALVNFTQAEVYAGNILYEHEMPPEPF 1667
Q L Y ++ P Q+ DS +++FTQA+V + Y+ PP+
Sbjct: 737 DQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQVNQHKVAYQ---PPQKL 793
Query: 1668 WEAHDTLEL--QLSSPPARDVAATLAVAVSFEAACPQRPSHLWKNKGLWVPEGQRARITV 1725
A ++ Q+ V T + F +P + N+G + EG
Sbjct: 794 GIAPRVVQFTYQVEDAAGNSVPGTFTL---FLQPVDNQPPEV-TNRGFAILEG------- 842
Query: 1726 AALDASNLLASVPSPQRSEHDVLFQVTQFPSRGQLLVSEEPLHAGQPHFLQSQLAAGQLV 1785
+ + S+ V P ++F + + P G L + + G+ F+Q+ + G +
Sbjct: 843 GSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKRCMVPGE-SFMQADVINGSVS 901
Query: 1786 YAHG-GGGTQQDGFHFRA-----HLQGPAGASVAGPQTSEAFAITVR-----DVNERPPQ 1834
Y HG T D FH H+ SV + + I++R DV+ +
Sbjct: 902 YQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVLE 961
Query: 1835 PQAS-VPLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTR 1893
+A+ + + + G R + LS + DS P G +++ GL P R
Sbjct: 962 NKATEITMGVIHGKRKDVGDLMLSFIVKDS------------PKLG--TILVNGL-PTER 1006
Query: 1894 FTQADVDSGRLAFVANGSSVA-----GIFQLSMSD-------GASPPLPMSLAVDILP-- 1939
FTQ D+ +GR+A+ V F L +S G S + + V +LP
Sbjct: 1007 FTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVD 1066
Query: 1940 SAIEVQLRAPLEVPQALGRSSLSQQQLRVVS-DREEPEAAYRLIQGPQYGHL-------- 1990
+ L + ++SL+ Q L V D + E + P G+L
Sbjct: 1067 NVGPKVLVGESFIVYEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEKIASAPG 1126
Query: 1991 ---LVGGRPTSAFSQFQIDQGEVVFA---FTNFSSSHDHFRVLALARGVNASAVVNVTV- 2043
G P SAFS I + + D F + G+N S V +
Sbjct: 1127 SKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQEDQF-TFYCSDGINFSPNVFFPII 1185
Query: 2044 ---------RALLHVWAGGPWPQGATLRLDPTVLDAGELANRTGSVPRFRLLEGPRHGRV 2094
+ H + +G +L +D +L+ + A+ + F+L PRHGR+
Sbjct: 1186 ILPTNDEQPKLFAHEF---KVLEGMSLVIDTQLLNGAD-ADLPPNELHFQLTALPRHGRI 1241
Query: 2095 VRVPRARTEPGGSQLVEQFTQQDLED 2120
++ GSQ + FT +++++
Sbjct: 1242 IQQLAT-----GSQPIHSFTLKEIQE 1262
Score = 90.1 bits (222), Expect = 2e-17
Identities = 202/865 (23%), Positives = 324/865 (37%), Gaps = 109/865 (12%)
Query: 421 LPPVFANFTQLLTISPLVVAEGGTAWLE---WRHVQPTLDLMEAELRKSQVLFSVTRGAR 477
+P F F Q + P V G A LE + L + + + Q++F + RG +
Sbjct: 814 VPGTFTLFLQPVDNQPPEVTNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQ 873
Query: 478 HGELELDIPGAQARKMFTLLDVVNRKARFIHDGSE-DTSDQLVLEVS-VTARVPMPSCLR 535
HG L+ + F DV+N + H + TSD LEVS +P+
Sbjct: 874 HGHLQYFKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVHHIPI----- 928
Query: 536 RGQTYLLPIQVNP--VNDPPHIIFPHGSLM----VILEHTQKPLGPEVFQAYDPDSACEG 589
+PI V+P N P I SL+ +LE+ + V D
Sbjct: 929 -----TIPISVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLM 983
Query: 590 LTFQV-----LGT--SSGLPVERRDQPGEPATEFSCRELEAGSLVYVHRGGPA----QDL 638
L+F V LGT +GLP ER F+ +L G + Y H G Q
Sbjct: 984 LSFIVKDSPKLGTILVNGLPTER----------FTQEDLINGRVAYAHTAGEVGFQKQHD 1033
Query: 639 TFRV---SDGLQ-----------ASPPATLKVVAIRPAIQIHRSTGLRLAQGSAMPILPA 684
F + D Q L V + P + + S + +G +
Sbjct: 1034 AFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVLVGES--FIVYEGEKNSLTLQ 1091
Query: 685 NLSVETNAVGQDVSVLFRVTGALQFGELQK--QGAGGVEGAEWWATQAFHQRDVEQGRVR 742
+L VE QD +L VT G L+K G AF RD++ +
Sbjct: 1092 HLHVEDVDTHQD-ELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHIN 1150
Query: 743 YLST-----DPQHHAYDTVENLALEVQVGQEILSNLSFPVTIQRATVWMLRLEPLHTQNT 797
Y+ + +PQ + G N+ FP+ I +L +
Sbjct: 1151 YVQSIHKGVEPQE------DQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVL 1204
Query: 798 QQETLTTAHLEATLEEAGPSPPTFHYEVVQAPRKGN-LQLQGTRLSDGQGFTQDDIQ-AG 855
+ +L +A P H+++ PR G +Q T FT +IQ A
Sbjct: 1205 EGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEIQEAS 1264
Query: 856 RVTYGATARASEAVEDTFRFRVTAPPYFSPLYTFPIHIGGDPDAPVLT-NVLLVVPEGGE 914
+ Y SE ED+F ++ + + + D + P LT N L V +G
Sbjct: 1265 TIVY--EHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKGHS 1322
Query: 915 GVLSADHLFVKSLNS--ASYLYEVMERPRHGRLAW----RG-TQDKTTMVTSFTNEDLLR 967
+++ L L+S S + + P+ G L RG ++ T+ +FT +++ R
Sbjct: 1323 EIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEINR 1382
Query: 968 GRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGVFRVAIQPVNDHAPVQTISRIF 1027
G + Y H E D I F T + D F V I ++ P + IS+
Sbjct: 1383 GLICYIHTGQEGIVDIIKFDVTDGVNTLTD-------HYFYVTIGNLDSVFP-EVISKRI 1434
Query: 1028 HVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIVAVDEPTRPIYRFTQEDLR 1087
+ G R LT + + SD +S + +TR L G + + D PI FTQ L
Sbjct: 1435 TLIEGARVTLTNNLLTNSDINSS-DEHHFSITRAPSL-GHLESSDYAGEPIASFTQLQLA 1492
Query: 1088 KRRVLFVHSGADR---GWIQLQVSDGQHQA-----TALLEVQASEPYLRVANGSSLVVPQ 1139
++ +VH+ D + QV + + +V +P L + L + +
Sbjct: 1493 SNKISYVHTSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTI---HRLTLQK 1549
Query: 1140 GGQGTIDTAVLHLDTNLDIRSGDEVHYHVTAGPRWGQLVRAG-QPATAFSQQDLLDGAVL 1198
I +L L D + + +T P G+++ G +P T F++QDL +
Sbjct: 1550 EDSQLI--TLLELTVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLIS 1607
Query: 1199 YSHNGSLSPRDTMAFSVEAGPVHTD 1223
Y H+GS + D+ + +V G HTD
Sbjct: 1608 YKHDGSETTEDSFSLTVTDG-THTD 1631
Score = 43.9 bits (102), Expect = 0.002
Identities = 43/150 (28%), Positives = 64/150 (42%), Gaps = 17/150 (11%)
Query: 437 LVVAEGGTAWLEWRHVQPTLDLMEAELRKSQVLFSVTRGARHGELELDIPGAQAR-KMFT 495
LV+ EG + L H P D E +V + RG RHG+L + GA A K FT
Sbjct: 441 LVLFEGQSRPLSSTHSIPISDKDNLE----EVKMAAVRGLRHGQLV--VFGAPAGCKYFT 494
Query: 496 LLDVVNRKARFIHDGSEDTSDQLVLEVSVTARVPMPSCLRRGQTYLLPIQVNPVNDPPHI 555
D+ + + HDGS SD ++ + +L P+ + PV+D P +
Sbjct: 495 PADLAAGRVVYQHDGSNTYSDNIIFRMEDG---------HHQVDFLFPLTILPVDDEPPM 545
Query: 556 IFPHGSLMVILEHTQKPLGPEVFQAYDPDS 585
+ + L + E + P V A D DS
Sbjct: 546 VNTNTGLS-LTEGQVVQISPFVLSATDIDS 574
Score = 42.7 bits (99), Expect = 0.004
Identities = 61/237 (25%), Positives = 88/237 (37%), Gaps = 45/237 (18%)
Query: 847 FTQDDIQAGRVTYGATARASE----------------AVEDTFRFRVTAPPYFSPLYTFP 890
FTQ +++ ++ Y A S A D F F VT + L
Sbjct: 377 FTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAASDPFAFMVTVKS-MNTLVPVA 435
Query: 891 IHIGGDPDAPVLTNVLLVVPEGGEGVLSADHLFVKSLNSASYLYEV----MERPRHGRLA 946
H G LV+ EG LS+ H ++ L EV + RHG+L
Sbjct: 436 SHNRG-----------LVLFEGQSRPLSSTHSI--PISDKDNLEEVKMAAVRGLRHGQLV 482
Query: 947 WRGTQDKTTMVTSFTNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGV 1006
G FT DL GR+VYQHD S T D+I F G D +
Sbjct: 483 VFGAPAGCKY---FTPADLAAGRVVYQHDGSNTYSDNIIF-RMEDGHHQVDF-------L 531
Query: 1007 FRVAIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDL 1063
F + I PV+D P+ + + G ++ ++ +D DS + VL + L
Sbjct: 532 FPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPL 588
>gi|169166334 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
sapiens]
Length = 2139
Score = 202 bits (513), Expect = 4e-51
Identities = 254/1044 (24%), Positives = 428/1044 (40%), Gaps = 109/1044 (10%)
Query: 950 TQDKTTMVTSFTNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGVFRV 1009
T T++ FT + + ++ YQ + T Q E D A V G F +
Sbjct: 765 TDSPDTLIMHFTQAQVNQHKVAYQPPQKLGIAPRV-VQFTYQVE---DAAGNSVPGTFTL 820
Query: 1010 AIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIV 1069
+QPV D+ P + +R F + GG L+++++ +D D+ +L R G +
Sbjct: 821 FLQPV-DNQPPEVTNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQ-HGHLQ 878
Query: 1070 AVDEPTRPIYRFTQEDLRKRRVLFVHSGADR----GWIQLQVSDGQHQATALLEVQAS-- 1123
P F Q D+ V + H G D+ L+VSDG H + +
Sbjct: 879 YFKRCMVPGESFMQADVINGSVSYQH-GRDQTTTSDTFHLEVSDGVHHIPITIPISVHPN 937
Query: 1124 ----EPYLRVANGS----SLVVPQGGQGTIDTAVLHLDTNLDIRSGD-EVHYHVTAGPRW 1174
P + + + S S+ V + I V+H D+ GD + + V P+
Sbjct: 938 VANRSPRISLRSSSLLDVSIDVLENKATEITMGVIH-GKRKDV--GDLMLSFIVKDSPKL 994
Query: 1175 GQLVRAGQPATAFSQQDLLDGAVLYSHN----GSLSPRDTMAFS--------VEAGPVHT 1222
G ++ G P F+Q+DL++G V Y+H G D + V +
Sbjct: 995 GTILVNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIE 1054
Query: 1223 DATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEIRRDQLEAAQEAVPPADIVFSVKSPP 1282
+QVT+ + P K+ + V++GE + L +++ +V S P
Sbjct: 1055 KVQVQVTVLPVDNVGP-KVFVGESFIVYEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQP 1113
Query: 1283 SAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLY---LHSRPEAWSDAFSLDVASG 1339
++GYL ++ + S P+ +FS + + Y +H E D F+ + G
Sbjct: 1114 ASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDG 1173
Query: 1340 LGAPLEGVLVELEVLPA---AIPLEAQNFSVPEGGSLTLAPPLLRVSGPYFPTLLGLSLQ 1396
+ V + +LP L A F V EG SL + LL + P L Q
Sbjct: 1174 INFS-PNVFFPIIILPTNDEQPKLFAHEFKVLEGMSLVIDTQLLNGADADLPPN-ELHFQ 1231
Query: 1397 VLEPPQHGALQKEDGPQARTLSAFSWRMVEE-QLIRYVHDGSETLTDSF-VLMANASEMD 1454
+ P+HG + ++ ++ + +F+ + ++E I Y HD SET DSF V +++
Sbjct: 1232 LTALPRHGRIIQQLATGSQPIHSFTLKEIQEASTIVYEHDDSETKEDSFEVWLSDGKHTT 1291
Query: 1455 RQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEALRSTDGDSGSEDLVYTIE 1514
+ P+ T+ V+D+ P LT N GL++ +G + I L++TD DS + L + +
Sbjct: 1292 HRKVPIVVTL----VDDETPHLTVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLH 1347
Query: 1515 Q-PSNGRVVLRGAPGTEVR-------SFTQAQLDGGLVLFSHRGT--LDGGFRFRLSDGE 1564
P G + P EVR +FTQ +++ GL+ + H G + +F ++DG
Sbjct: 1348 SGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGV 1407
Query: 1565 HTSPGHFFRVT-AQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASSSAGTDPQLLLYRVV 1623
+T H+F VT + S+ +T+ G+ L++ L S +D + +
Sbjct: 1408 NTLTDHYFYVTIGNLDSVFPEVISKRITLIEGARVTLTNNLLTNSDINSSDEH--HFSIT 1465
Query: 1624 RGPQLGRLFHAQQDSTGEALVNFTQAEVYAGNILYEHEMPPEPFWEAHDTLELQLSSPPA 1683
R P LG L D GE + +FTQ ++ + I Y H E + D+ E Q+
Sbjct: 1466 RAPSLGHL--ESSDYAGEPIASFTQLQLASNKISYVHTSNDE---KKMDSFEFQVIG-EL 1519
Query: 1684 RDVAATLAVAVS-FEAACPQRPSHLWKNKGLWVPEGQRARITVAALDA---SNLLASVPS 1739
V T + ++ + P H R+T+ D+ + L +V
Sbjct: 1520 YPVFRTFRIFITDVDNKKPILTIH---------------RLTLQKEDSQLITLLELTVED 1564
Query: 1740 PQRSEHDVLFQVTQFPSRGQLLVS-EEPLHAGQPHFLQSQLAAGQLVYAHGGGGTQQDGF 1798
+ +LF +TQ P G++L + P+ F + L + Y H G T +D F
Sbjct: 1565 SDTPDDLILFTITQVPMHGKILYNGSRPVTT----FTKQDLNKNLISYKHDGSETTEDSF 1620
Query: 1799 HFRAHLQGPAGASVAGPQTS------EAFAITVRDVNERPPQ----PQASVPLRLTRGSR 1848
G P T+ + + +R ++ R PQ A RL G
Sbjct: 1621 SLTV-TDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHM 1679
Query: 1849 A-PISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQADVDSGRLAFV 1907
I+ L D DS ++Y+V R P +GF+ G G FTQAD+D ++++V
Sbjct: 1680 GFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTRVFTQADIDEMKISYV 1739
Query: 1908 ANGSSVAG--IFQLSMSDGASPPL 1929
N S A IF S+ D L
Sbjct: 1740 LNEGSNASKDIFYFSVEDNGGNKL 1763
Score = 177 bits (448), Expect = 1e-43
Identities = 280/1166 (24%), Positives = 482/1166 (41%), Gaps = 161/1166 (13%)
Query: 956 MVTSFTNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGVFRVAIQPVN 1015
+VT + D++ GRL Y+H + + + +A + D + +F + +QPV+
Sbjct: 641 VVTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHV-QDDHDPPNLSKQHIFTIKVQPVD 699
Query: 1016 DHAPV--------QTIS--RIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKD--- 1062
+P T+ ++ H + R + D SD + + + T D
Sbjct: 700 ILSPQLYPGTTLEMTVQEYQLTHFQKNFLRYIDQD----SDDQNLWYTLLTLPTDTDGNH 755
Query: 1063 -LLFGSIVAVDEPTRPIYRFTQEDLRKRRVLF---VHSGADRGWIQL--QVSDGQHQA-- 1114
+ G IV D P I FTQ + + +V + G +Q QV D +
Sbjct: 756 QVRAGEIVLTDSPDTLIMHFTQAQVNQHKVAYQPPQKLGIAPRVVQFTYQVEDAAGNSVP 815
Query: 1115 -TALLEVQASEPYLRVANGSSLVVPQGGQGTIDTAVLHL-DTNLDIRSGDEVHYHVTAGP 1172
T L +Q + + +GG + + LH+ D + DI D++ + + GP
Sbjct: 816 GTFTLFLQPVDNQPPEVTNRGFAILEGGSFNLSSNELHVTDPDTDI---DQIVFILVRGP 872
Query: 1173 RWGQL---VRAGQPATAFSQQDLLDGAVLYSH-NGSLSPRDTMAFSVEAGPVHTDATLQV 1228
+ G L R P +F Q D+++G+V Y H + DT V G H T+ +
Sbjct: 873 QHGHLQYFKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVHHIPITIPI 932
Query: 1229 T----IALEGPLAPLK--LVRHKKIYVFQGEAAEIRRDQLEAAQEAVPPADIVFSVKSPP 1282
+ +A P L+ + I V + +A EI + ++ V + F VK P
Sbjct: 933 SVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLMLSFIVKDSP 992
Query: 1283 SAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLYLHSRPEA----WSDAFSLDVAS 1338
G +++ P + F+QE + GRV Y H+ E DAFSL ++
Sbjct: 993 KLGTILVNGL-----------PTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSK 1041
Query: 1339 GL------GAPLEGVLVELEVLP----AAIPLEAQNFSVPEG--GSLTLAPPLLRVSGPY 1386
+ +E V V++ VLP ++F V EG SLTL + +
Sbjct: 1042 DSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVFVGESFIVYEGEKNSLTLQHLHVEDVDTH 1101
Query: 1387 FPTLLGLSLQVLEPPQHGALQK-------EDGPQARTLSAFSWRMVEEQLIRYV---HDG 1436
LL V P G L+K + +SAFS R ++ + I YV H G
Sbjct: 1102 QDELL---CTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHKG 1158
Query: 1437 SETLTDSFVLMANASEMDRQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEA 1496
E D F S+ S V F + +LP ND+ P L + ++ EG + I +
Sbjct: 1159 VEPQEDQFTFY--CSDGINFSPNVFFPIIILPTNDEQPKLFAHE-FKVLEGMSLVIDTQL 1215
Query: 1497 LRSTDGDSGSEDLVYTIEQ-PSNGRVVLRGAPGTE-VRSFTQAQL-DGGLVLFSH--RGT 1551
L D D +L + + P +GR++ + A G++ + SFT ++ + +++ H T
Sbjct: 1216 LNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEIQEASTIVYEHDDSET 1275
Query: 1552 LDGGFRFRLSDGEHTSPGHF-FRVTAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASSS 1610
+ F LSDG+HT+ VT L + L V G + ++++ L+A +
Sbjct: 1276 KEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKGHSEIITNRILKA-TD 1334
Query: 1611 AGTDPQLLLYRVVRGPQLGRLFHAQQDSTGEAL------VNFTQAEVYAGNILYEHEMPP 1664
+D + L + + GPQ G L + GE +NFTQ E+ G I Y H
Sbjct: 1335 LDSDDKSLSFVLHSGPQQG-LLQRLRKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQE 1393
Query: 1665 EPFWEAHDTLELQLSSPPARDVAATLAVAV-SFEAACPQRPSHLWKNKGLWVPEGQRARI 1723
D ++ ++ V + + ++ P+ S K + + EG R +
Sbjct: 1394 ----GIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVIS-----KRITLIEGARVTL 1444
Query: 1724 TVAALDASNLLASVPSPQRSEHDVLFQVTQFPSRGQLLVSEEPLHAGQP--HFLQSQLAA 1781
T +NLL + EH F +T+ PS G L S+ +AG+P F Q QLA+
Sbjct: 1445 T------NNLLTNSDINSSDEHH--FSITRAPSLGHLESSD---YAGEPIASFTQLQLAS 1493
Query: 1782 GQLVYAHGGGGTQQ-DGFHFRAHLQGPAGASVAGP--QTSEAFAITVRDVNERPPQPQAS 1838
++ Y H ++ D F F+ V G F I + DV+ + P
Sbjct: 1494 NKISYVHTSNDEKKMDSFEFQ----------VIGELYPVFRTFRIFITDVDNKKPILTIH 1543
Query: 1839 VPLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQAD 1898
L L + I+ +L+V D D+ I + + + P +G ++ G PVT FT+ D
Sbjct: 1544 -RLTLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHG--KILYNGSRPVTTFTKQD 1600
Query: 1899 VDSGRLAFVANGS-SVAGIFQLSMSDGASPP---LPMSLAVDILPSAIEVQLRA-PLEVP 1953
++ +++ +GS + F L+++DG LP + P + VQ+R+ +P
Sbjct: 1601 LNKNLISYKHDGSETTEDSFSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLP 1660
Query: 1954 Q--------ALGRSSLSQQQLRVVS------DREEPE--AAYRLIQGPQYGHLL---VGG 1994
Q AL R + S D++ P Y++ +GP++G ++ +G
Sbjct: 1661 QITTNRGAPALKRLHTGHMGFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGN 1720
Query: 1995 RPTSAFSQFQIDQGEVVFAFTNFSSS 2020
+ T F+Q ID+ ++ + S++
Sbjct: 1721 QSTRVFTQADIDEMKISYVLNEGSNA 1746
Score = 128 bits (322), Expect = 6e-29
Identities = 204/908 (22%), Positives = 368/908 (40%), Gaps = 111/908 (12%)
Query: 825 VVQAPRKGNLQLQGTRLSDGQGFTQDDIQAGRVTYGATARASEAVEDTFRFRVTAPPYFS 884
+V+ P+ G+LQ + G+ F Q D+ G V+Y R DTF V+ +
Sbjct: 868 LVRGPQHGHLQYFKRCMVPGESFMQADVINGSVSY-QHGRDQTTTSDTFHLEVSDGVHHI 926
Query: 885 PLYTFPIHI-----GGDPDAPVLTNVLLVVP------EGGEGVLSADHLFVKSLNSASYL 933
P+ T PI + P + ++ LL V + E + H K +
Sbjct: 927 PI-TIPISVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLMLS 985
Query: 934 YEVMERPRHGRLAWRGTQDKTTMVTSFTNEDLLRGRLVYQHDDSET----TEDDIPFVAT 989
+ V + P+ G + G + FT EDL+ GR+ Y H E D + +
Sbjct: 986 FIVKDSPKLGTILVNGLPTE-----RFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILS 1040
Query: 990 RQGES--SGDMAWEEVRGVFRVAIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDA 1047
+ G+ E+V+ +V + PV++ P + F V G + LT + D
Sbjct: 1041 KDSYQWVVGNSIIEKVQ--VQVTVLPVDNVGPKVFVGESFIVYEGEKNSLTLQHLHVEDV 1098
Query: 1048 DSGFADAQLVLTRKDLLFGSIVAV--------DEPTRPIYRFTQEDLRKRRVLFV---HS 1096
D+ D L G + + + PI F+ D++ R + +V H
Sbjct: 1099 DT-HQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHK 1157
Query: 1097 GAD--RGWIQLQVSDGQHQA------TALLEVQASEPYL-----RVANGSSLVVPQGGQG 1143
G + SDG + + +L +P L +V G SLV
Sbjct: 1158 GVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVLEGMSLV------- 1210
Query: 1144 TIDTAVLH-LDTNLDIRSGDEVHYHVTAGPRWG----QLVRAGQPATAFSQQDLLDGA-V 1197
IDT +L+ D +L +E+H+ +TA PR G QL QP +F+ +++ + + +
Sbjct: 1211 -IDTQLLNGADADL---PPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEIQEASTI 1266
Query: 1198 LYSHNGSLSPRDTMAFSVEAGPVHTDATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEI 1257
+Y H+ S + D+ + G T + + + L P L + + V +G + I
Sbjct: 1267 VYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETP-HLTVNNGLKVEKGHSEII 1325
Query: 1258 RRDQLEAAQEAVPPADIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGR 1317
L+A + F + S P G L + R + +L +F+Q+ ++ G
Sbjct: 1326 TNRILKATDLDSDDKSLSFVLHSGPQQGLLQRL-RKPRGEVRNNLTLGMNFTQDEINRGL 1384
Query: 1318 VLYLHSRPEAWSDAFSLDVASGLGAPLEGVL-VELEVLPAAIP-LEAQNFSVPEGGSLTL 1375
+ Y+H+ E D DV G+ + V + L + P + ++ ++ EG +TL
Sbjct: 1385 ICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVISKRITLIEGARVTL 1444
Query: 1376 APPLLRVSGPYFPTLLGLSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVH- 1434
LL S + + P G L+ D +++F+ + I YVH
Sbjct: 1445 TNNLLTNSD--INSSDEHHFSITRAPSLGHLESSD-YAGEPIASFTQLQLASNKISYVHT 1501
Query: 1435 DGSETLTDSFVLMANASEMDRQSHPV--AFTVTVLPVNDQPPILTTNTGLQMWEGATAPI 1492
E DSF ++ + +PV F + + V+++ PILT + L + + + I
Sbjct: 1502 SNDEKKMDSFEF-----QVIGELYPVFRTFRIFITDVDNKKPILTIHR-LTLQKEDSQLI 1555
Query: 1493 PAEALRSTDGDSGSEDLVYTIEQ-PSNGRVVLRGAPGTEVRSFTQAQLDGGLVLFSHRG- 1550
L D D+ + +++TI Q P +G+++ G+ V +FT+ L+ L+ + H G
Sbjct: 1556 TLLELTVEDSDTPDDLILFTITQVPMHGKILYNGS--RPVTTFTKQDLNKNLISYKHDGS 1613
Query: 1551 -TLDGGFRFRLSDGEHTS----PGHFFRVTAQKQVLLSLKGSQT----LTVCPGSVQ--- 1598
T + F ++DG HT P + + + ++ +T G+
Sbjct: 1614 ETTEDSFSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKR 1673
Query: 1599 --------PLSSQTLRASSSAGTDPQLLLYRVVRGPQLGRLFHAQQDSTGEALVNFTQAE 1650
++S++L+A + +LL Y+V RGP+ G F + ++ FTQA+
Sbjct: 1674 LHTGHMGFLITSKSLKAEDQ-DSPHRLLKYKVTRGPEHG--FIIKTGLGNQSTRVFTQAD 1730
Query: 1651 VYAGNILY 1658
+ I Y
Sbjct: 1731 IDEMKISY 1738
Score = 114 bits (286), Expect = 9e-25
Identities = 212/973 (21%), Positives = 373/973 (38%), Gaps = 117/973 (12%)
Query: 546 VNPVNDPPHIIFPHGSLMVILEHTQKPLGPEVFQAYDPDSACEGLTFQVLGTSSGLPVER 605
+ PV++ P + G ILE L DPD+ + + F ++ ++
Sbjct: 822 LQPVDNQPPEVTNRG--FAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQY 879
Query: 606 RDQPGEPATEFSCRELEAGSLVYVH-RGGPAQDLTFR--VSDGLQASP---PATL--KVV 657
+ P F ++ GS+ Y H R TF VSDG+ P P ++ V
Sbjct: 880 FKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNVA 939
Query: 658 AIRPAIQIHRSTGLRLA----QGSAMPILPANLSVETNAVGQDVSVLFRVTGALQFGELQ 713
P I + S+ L ++ + A I + + VG D+ + F V + + G +
Sbjct: 940 NRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVG-DLMLSFIVKDSPKLGTIL 998
Query: 714 KQGAGGVEGAEWWATQAFHQRDVEQGRVRYLST------DPQHHAYDTV-ENLALEVQVG 766
G T+ F Q D+ GRV Y T QH A+ + + + VG
Sbjct: 999 VNGL---------PTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSKDSYQWVVG 1049
Query: 767 QEILSNLSFPVT---IQRATVWMLRLEPLHTQNTQQETLTTAHLEATLEEAGPSPPTFHY 823
I+ + VT + + E ++ +LT HL +E+
Sbjct: 1050 NSIIEKVQVQVTVLPVDNVGPKVFVGESFIVYEGEKNSLTLQHLH--VEDVDTHQDELLC 1107
Query: 824 EVVQAPRKGNLQ----LQGTRLSDG----QGFTQDDIQAGRVTY-GATARASEAVEDTFR 874
V P G L+ G+++S F+ DIQ + Y + + E ED F
Sbjct: 1108 TVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQEDQFT 1167
Query: 875 FRVTAPPYFSPLYTFPIHI-GGDPDAPVLTNVLLVVPEGGEGVLSADHL--FVKSLNSAS 931
F + FSP FPI I + + P L V EG V+ L L
Sbjct: 1168 FYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVLEGMSLVIDTQLLNGADADLPPNE 1227
Query: 932 YLYEVMERPRHGRLAWR---GTQDKTTMVTSFTNEDLLR-GRLVYQHDDSETTEDDIPFV 987
+++ PRHGR+ + G+Q + SFT +++ +VY+HDDSET ED V
Sbjct: 1228 LHFQLTALPRHGRIIQQLATGSQP----IHSFTLKEIQEASTIVYEHDDSETKEDSFE-V 1282
Query: 988 ATRQGESSGDMAWEEVRGVFRVAIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDA 1047
G+ + + + V+D P T++ V +G ++T + +D
Sbjct: 1283 WLSDGKHT-------THRKVPIVVTLVDDETPHLTVNNGLKVEKGHSEIITNRILKATDL 1335
Query: 1048 DSGFADAQLVLTRKDLLFGSIVAVDEPTRPI-------YRFTQEDLRKRRVLFVHSGADR 1100
DS VL G + + +P + FTQ+++ + + ++H+G +
Sbjct: 1336 DSDDKSLSFVL-HSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQEG 1394
Query: 1101 --GWIQLQVSDGQHQAT---ALLEVQASEPYLRVANGSSLVVPQGGQGTIDTAVLHLDTN 1155
I+ V+DG + T + + + + + +G + T+ +L TN
Sbjct: 1395 IVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVISKRITLIEGARVTLTNNLL---TN 1451
Query: 1156 LDIRSGDEVHYHVTAGPRWGQLVR---AGQPATAFSQQDLLDGAVLYSHNGSLSPR-DTM 1211
DI S DE H+ +T P G L AG+P +F+Q L + Y H + + D+
Sbjct: 1452 SDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQLQLASNKISYVHTSNDEKKMDSF 1511
Query: 1212 AFSVEAGPVHTDATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEIRRDQLEAAQEAVPP 1271
F V T ++ I P+ + ++ + + ++ I +L P
Sbjct: 1512 EFQVIGELYPVFRTFRIFITDVDNKKPILTIH--RLTLQKEDSQLITLLELTVEDSDTPD 1569
Query: 1272 ADIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLYLHSRPEAWSDA 1331
I+F++ P G ++ PV +F+++ ++ + Y H E D+
Sbjct: 1570 DLILFTITQVPMHGKILY----------NGSRPVTTFTKQDLNKNLISYKHDGSETTEDS 1619
Query: 1332 FSLDVASGLGAPL----EGVLVELEVLPAAIPLEAQNFSVPEGGSLTLAPPLLRVSGPYF 1387
FSL V G + L + + + + + +P+ + AP L R+ +
Sbjct: 1620 FSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHM 1679
Query: 1388 PTLLG---------------LSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRY 1432
L+ L +V P+HG + K G ++ F+ ++E I Y
Sbjct: 1680 GFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIK-TGLGNQSTRVFTQADIDEMKISY 1738
Query: 1433 V-HDGSETLTDSF 1444
V ++GS D F
Sbjct: 1739 VLNEGSNASKDIF 1751
Score = 103 bits (256), Expect = 3e-21
Identities = 157/711 (22%), Positives = 286/711 (40%), Gaps = 112/711 (15%)
Query: 1400 PPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVHDGSETLTDS-FVLMANASEMD-RQS 1457
P Q G + D P +S F+ + + E I Y + + F L + D S
Sbjct: 357 PGQQGYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAAS 416
Query: 1458 HPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPA-EALRSTDGDSGSEDLVYTIEQP 1516
P AF VTV +N P+ + N GL ++EG + P+ + ++ +D D+ E + +
Sbjct: 417 DPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSSTHSIPISDKDNLEEVKMAAVRGL 476
Query: 1517 SNGRVVLRGAPGTEVRSFTQAQLDGGLVLFSHRG--TLDGGFRFRLSDGEHTS----PGH 1570
+G++V+ GAP + FT A L G V++ H G T FR+ DG H P
Sbjct: 477 RHGQLVVFGAPAG-CKYFTPADLAAGRVVYQHDGSNTYSDNIIFRMEDGHHQVDFLFPLT 535
Query: 1571 FFRVTAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASSSAGTDPQL---LLYRVVRG-- 1625
V + ++ + G L++ G V +S L A+ D + L + ++G
Sbjct: 536 ILPVDDEPPMVNTNTG---LSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPLKGNE 592
Query: 1626 --PQ-------------LGRLFHAQQD---STGE--------------ALVNFTQAEVYA 1653
PQ LG L Q + ST + + + Q ++
Sbjct: 593 EEPQWELAPGSSHSGHYLGDLLLQQAELPLSTEDEDWHYMEKEGLYEKVVTEWLQRDIME 652
Query: 1654 GNILYEHEMPPEP----------FWEAHDTLELQ------LSSPPARDVAATLAVAVSFE 1697
G + Y H P P + HD L + P ++ L + E
Sbjct: 653 GRLFYRHLGPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDILSPQLYPGTTLE 712
Query: 1698 AACPQ-RPSHLWKNKGLWVPEGQRARITVAALDASNL---LASVPSPQRSEHDVLFQVTQ 1753
+ + +H KN ++ + D NL L ++P+ H V
Sbjct: 713 MTVQEYQLTHFQKNFLRYIDQDS---------DDQNLWYTLLTLPTDTDGNHQV------ 757
Query: 1754 FPSRGQLLVSEEPLHAGQPHFLQSQLAAGQLVYAHGGG-GTQQDGFHFRAHLQGPAGASV 1812
G++++++ P HF Q+Q+ ++ Y G F ++ AG SV
Sbjct: 758 --RAGEIVLTDSP-DTLIMHFTQAQVNQHKVAYQPPQKLGIAPRVVQFTYQVEDAAGNSV 814
Query: 1813 AGPQTSEAFAITVRDVNERPPQPQASVPLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEV 1872
G F + ++ V+ +PP+ + + G +S +L V DPD+ +I + +
Sbjct: 815 PG-----TFTLFLQPVDNQPPEV-TNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFIL 868
Query: 1873 QRAPHNGFLSLVGGGLGPVTRFTQADVDSGRLAFV--ANGSSVAGIFQLSMSDGASPPLP 1930
R P +G L + P F QADV +G +++ + ++ + F L +SDG +P
Sbjct: 869 VRGPQHGHLQYFKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVH-HIP 927
Query: 1931 MSLAVDILPSA------IEVQLRAPLEVPQALGRSSLSQQQLRVVSDREEPEA----AYR 1980
+++ + + P+ I ++ + L+V + + ++ + V+ + + ++
Sbjct: 928 ITIPISVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLMLSFI 987
Query: 1981 LIQGPQYGHLLVGGRPTSAFSQFQIDQGEVVFAFT----NFSSSHDHFRVL 2027
+ P+ G +LV G PT F+Q + G V +A T F HD F ++
Sbjct: 988 VKDSPKLGTILVNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLI 1038
Score = 101 bits (252), Expect = 7e-21
Identities = 216/981 (22%), Positives = 375/981 (38%), Gaps = 175/981 (17%)
Query: 1242 VRHKKIYVFQGEAAEIRRDQLEAAQEAVPPADIVFSVKSPPSAGYLVMVSRGALADEPPS 1301
V ++ + +G + + ++L IVF + P G+L R
Sbjct: 832 VTNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKR--------C 883
Query: 1302 LDPVQSFSQEAVDTGRVLYLHSRPEAW-SDAFSLDVASGLGAPLEGVLVELEVLPAAIPL 1360
+ P +SF Q V G V Y H R + SD F L+V+ G+ +P IP+
Sbjct: 884 MVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGV-----------HHIPITIPI 932
Query: 1361 EAQNFSVPEGGSLTLAPPLLRVSGPYFPTLLGLSLQVLEPPQ--------HGALQK---- 1408
++L +LL +S+ VLE HG +
Sbjct: 933 SVHPNVANRSPRISLRSS----------SLLDVSIDVLENKATEITMGVIHGKRKDVGDL 982
Query: 1409 ------EDGPQARTLSAFSW---RMVEEQLIR----YVHDGSET----LTDSFVLMANAS 1451
+D P+ T+ R +E LI Y H E D+F L+ +
Sbjct: 983 MLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSKD 1042
Query: 1452 EM-----DRQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEALRSTDGDSGS 1506
+ V VTVLPV++ P + ++EG + + L D D+
Sbjct: 1043 SYQWVVGNSIIEKVQVQVTVLPVDNVGPKVFVGESFIVYEGEKNSLTLQHLHVEDVDTHQ 1102
Query: 1507 EDLVYTI-EQPSNGRVV-LRGAPGTE-------VRSFTQAQLDG---GLVLFSHRGT--L 1552
++L+ T+ QP++G + + APG++ + +F+ + V H+G
Sbjct: 1103 DELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQ 1162
Query: 1553 DGGFRFRLSDGEHTSPGHFFRV----TAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRAS 1608
+ F F SDG + SP FF + T +Q L + V G + +Q L +
Sbjct: 1163 EDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLF---AHEFKVLEGMSLVIDTQLLNGA 1219
Query: 1609 SSAGTDPQLLLYRVVRGPQLGRLFHAQQDSTG-EALVNFTQAEVY-AGNILYEHEMPPEP 1666
A P L +++ P+ GR+ QQ +TG + + +FT E+ A I+YEH+
Sbjct: 1220 D-ADLPPNELHFQLTALPRHGRII--QQLATGSQPIHSFTLKEIQEASTIVYEHDDSETK 1276
Query: 1667 FWEAHDTLELQLSSPPARDVAATLAVAVSFEAACPQRPSHLWKNKGLWVPEGQRARITVA 1726
D+ E+ LS V + P HL N GL V +G IT
Sbjct: 1277 ----EDSFEVWLSDGKHTTHRKVPIVVTLVDDETP----HLTVNNGLKVEKGHSEIITNR 1328
Query: 1727 ALDASNLLASVPSPQRSEHDVLFQVTQFPSRGQLLVSEEP-------LHAGQPHFLQSQL 1779
L A++L + + F + P +G L +P L G +F Q ++
Sbjct: 1329 ILKATDL-------DSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGM-NFTQDEI 1380
Query: 1780 AAGQLVYAHGGGGTQQDGFHFRAHLQGPAGASVAGPQTSEAFAITVRDVNERPPQPQASV 1839
G + Y H G Q+G G + T F +T+ +++ P+ S
Sbjct: 1381 NRGLICYIHTG----QEGIVDIIKFDVTDGVNTL---TDHYFYVTIGNLDSVFPEV-ISK 1432
Query: 1840 PLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQADV 1899
+ L G+R ++ L+ D +S+ E + + RAP G L P+ FTQ +
Sbjct: 1433 RITLIEGARVTLTNNLLTNSDINSSD-EHHFSITRAPSLGHLESSDYAGEPIASFTQLQL 1491
Query: 1900 DSGRLAFV--ANGSSVAGIFQLSMSDGASPPLPMSLAVDILPSAIEVQLRAPLEVPQALG 1957
S ++++V +N F+ + G P+ + + I +V + P+ L
Sbjct: 1492 ASNKISYVHTSNDEKKMDSFEFQVI-GELYPVFRTFRIFI----TDVDNKKPILTIHRLT 1546
Query: 1958 RSSLSQQQLRV----VSDREEPE--AAYRLIQGPQYGHLLV-GGRPTSAFSQFQIDQG-- 2008
Q + + V D + P+ + + Q P +G +L G RP + F++ +++
Sbjct: 1547 LQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLI 1606
Query: 2009 ----------EVVFAFTNFSSSHDHFRVLA-LARGVNASAVVNVTVRALLHVWAGGPWPQ 2057
E F+ T +H F VL A + V+ V +R+L PQ
Sbjct: 1607 SYKHDGSETTEDSFSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSL-----DNRLPQ 1661
Query: 2058 GATLRLDPTV--LDAGELA-------------NRTGSVPRFRLLEGPRHGRVVRVPRART 2102
T R P + L G + + + ++++ GP HG +++
Sbjct: 1662 ITTNRGAPALKRLHTGHMGFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGL--- 1718
Query: 2103 EPGGSQLVEQFTQQDLEDGRL 2123
G+Q FTQ D+++ ++
Sbjct: 1719 ---GNQSTRVFTQADIDEMKI 1736
Score = 101 bits (251), Expect = 1e-20
Identities = 161/691 (23%), Positives = 279/691 (40%), Gaps = 64/691 (9%)
Query: 438 VVAEGGTAWLEWRHVQPTLDLMEAELRKSQVLFSVTRGARHGELELDIPGAQARKM---- 493
+V EG L +H L + + + + ++L +VT G LE I A KM
Sbjct: 1079 IVYEGEKNSLTLQH----LHVEDVDTHQDELLCTVTSQPASGYLE-KIASAPGSKMSQSG 1133
Query: 494 -----FTLLDVVNRKARF---IHDGSEDTSDQLVLEVSVTARVPMPSCLRRGQTYLLPIQ 545
F+L D+ R + IH G E DQ S + PI
Sbjct: 1134 SPISAFSLRDIQVRHINYVQSIHKGVEPQEDQFTFYCS--------DGINFSPNVFFPII 1185
Query: 546 VNPVNDPPHIIFPHGSLMVILEHTQKPLGPEVFQAYDPDSACEGLTFQVLGTSS-GLPVE 604
+ P ND +F H +LE + ++ D D L FQ+ G ++
Sbjct: 1186 ILPTNDEQPKLFAHE--FKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQ 1243
Query: 605 RRDQPGEPATEFSCREL-EAGSLVYVHRGGPAQDLTFRV--SDGLQASPPATLKVVAIRP 661
+ +P F+ +E+ EA ++VY H ++ +F V SDG + VV +
Sbjct: 1244 QLATGSQPIHSFTLKEIQEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVD 1303
Query: 662 AIQIHRST--GLRLAQGSAMPILPANLSVETNAVGQDVSVLFRVTGALQFGELQK-QGAG 718
H + GL++ +G + I+ + T+ D S+ F + Q G LQ+ +
Sbjct: 1304 DETPHLTVNNGLKVEKGHS-EIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPR 1362
Query: 719 GVEGAEWWATQAFHQRDVEQGRVRYLSTDPQHHAYDTVENLALEVQVGQEILSNLSFPVT 778
G F Q ++ +G + Y+ T + V+ + +V G L++ F VT
Sbjct: 1363 GEVRNNLTLGMNFTQDEINRGLICYIHTGQE----GIVDIIKFDVTDGVNTLTDHYFYVT 1418
Query: 779 IQRATVWMLRLEPLHTQNTQQETLTTAHLEATLEEAGPSPPTFHYEVVQAPRKGNLQLQG 838
I + + +T + T + S H+ + +AP G+L+
Sbjct: 1419 IGNLDSVFPEVISKRITLIEGARVTLTNNLLTNSDINSSDE-HHFSITRAPSLGHLESSD 1477
Query: 839 TRLSDGQGFTQDDIQAGRVTYGATARASEAVEDTFRFRVTAPPYFSPLY-TFPIHIGG-D 896
FTQ + + +++Y T+ E D+F F+V Y P++ TF I I D
Sbjct: 1478 YAGEPIASFTQLQLASNKISYVHTSN-DEKKMDSFEFQVIGELY--PVFRTFRIFITDVD 1534
Query: 897 PDAPVLTNVLLVVPEGGEGVLSADHLFVKSLNSAS--YLYEVMERPRHGRLAWRGTQDKT 954
P+LT L + + +++ L V+ ++ L+ + + P HG++ + G++
Sbjct: 1535 NKKPILTIHRLTLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKILYNGSRP-- 1592
Query: 955 TMVTSFTNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESS----GDMAWEEVR-GVFRV 1009
VT+FT +DL + + Y+HD SETTED T + D A + V RV
Sbjct: 1593 --VTTFTKQDLNKNLISYKHDGSETTEDSFSLTVTDGTHTDFYVLPDTALATHKPQVMRV 1650
Query: 1010 AIQPVNDHAPVQTISR------IFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDL 1063
I+ +++ P T +R H G L+T+ + D DS + +TR
Sbjct: 1651 QIRSLDNRLPQITTNRGAPALKRLHTGHMG-FLITSKSLKAEDQDSPHRLLKYKVTRGP- 1708
Query: 1064 LFGSIVAVDEPTRPIYRFTQEDLRKRRVLFV 1094
G I+ + FTQ D+ + ++ +V
Sbjct: 1709 EHGFIIKTGLGNQSTRVFTQADIDEMKISYV 1739
Score = 97.1 bits (240), Expect = 2e-19
Identities = 275/1342 (20%), Positives = 484/1342 (36%), Gaps = 205/1342 (15%)
Query: 917 LSADHLFVKSLNS--ASYLYEVMERPRH--GRLAWRG----TQDKTTM-VTSFTNEDLLR 967
L+ D L + + S ++ ++ P H G +G T D + V+ FT ++L
Sbjct: 325 LTPDALAAEDVESDPGDLVFNILNAPTHPPGHPGQQGYVVSTDDPLGLPVSFFTQQELRE 384
Query: 968 GRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRG--------VFRVAIQPVNDHAP 1019
++ YQ P GE + E V G F V ++ +N P
Sbjct: 385 LKIAYQ-----------PPAENSHGERLFQLELEVVDGDGAASDPFAFMVTVKSMNTLVP 433
Query: 1020 VQTISRIFHVARG-GRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIVAVDEPTRPI 1078
V + +R + G R L +T + SD D+ + ++ R L G +V P
Sbjct: 434 VASHNRGLVLFEGQSRPLSSTHSIPISDKDN-LEEVKMAAVR-GLRHGQLVVFGAPAGCK 491
Query: 1079 YRFTQEDLRKRRVLFVHSGADR--GWIQLQVSDGQHQATAL-----LEVQASEPYLRVAN 1131
Y FT DL RV++ H G++ I ++ DG HQ L L V P +
Sbjct: 492 Y-FTPADLAAGRVVYQHDGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVDDEPPMVNTNT 550
Query: 1132 GSSLVVPQGGQ-----------GTIDTAVLHLDTNLDIRSGDEV-------------HYH 1167
G SL Q Q + D+ + + N ++ +E HY
Sbjct: 551 GLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPLKGNEEEPQWELAPGSSHSGHYL 610
Query: 1168 ------------VTAGPRWGQLVRAG---QPATAFSQQDLLDGAVLYSHNGSLSPRDTM- 1211
T W + + G + T + Q+D+++G + Y H G SP+ M
Sbjct: 611 GDLLLQQAELPLSTEDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHLGPHSPQSVMV 670
Query: 1212 --AFSVEAGPVHTDATLQVTIALEGPLAPLKLVRHK-------KIYVFQGEAAEIRRDQL 1262
AF V+ H L + P+ ++ + ++ V + + +++ L
Sbjct: 671 QLAFHVQDD--HDPPNLSKQHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQLTHFQKNFL 728
Query: 1263 EAAQEAVPPADIVFSVKSPPS---AGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVL 1319
+ ++ +++ + P+ + V L D P +L + F+Q V+ +V
Sbjct: 729 RYIDQDSDDQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSPDTL--IMHFTQAQVNQHKVA 786
Query: 1320 Y-----LHSRPEAWSDAFSLDVASGLGAPLEGVLVELEVLPAAIPLEAQNFSVPEGGSLT 1374
Y L P + ++ A+G P L V + + F++ EGGS
Sbjct: 787 YQPPQKLGIAPRVVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPPEVTNRGFAILEGGSFN 846
Query: 1375 LAPPLLRVSGPYFPTLLGLSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVH 1434
L+ L V+ P + + ++ PQHG LQ +F V + Y H
Sbjct: 847 LSSNELHVTDP-DTDIDQIVFILVRGPQHGHLQYFKRCMVPG-ESFMQADVINGSVSYQH 904
Query: 1435 DGSETLT-DSFVLMANASEMDRQSH-PVAFTVTVLP--VNDQPPILTTNTGL-----QMW 1485
+T T D+F L + D H P+ ++V P N P I ++ L +
Sbjct: 905 GRDQTTTSDTFHLEVS----DGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVL 960
Query: 1486 EGATAPIPAEALRSTDGDSGSEDLVYTI-EQPSNGRVVLRGAPGTEVRSFTQAQLDGGLV 1544
E I + D G L + + + P G +++ G P FTQ L G V
Sbjct: 961 ENKATEITMGVIHGKRKDVGDLMLSFIVKDSPKLGTILVNGLP---TERFTQEDLINGRV 1017
Query: 1545 LFSHRGTLDG------GFRFRLS-DGEHTSPGHFFRVTAQKQVLL--------SLKGSQT 1589
++H G F LS D G+ Q QV + + ++
Sbjct: 1018 AYAHTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVFVGES 1077
Query: 1590 LTVCPGSVQPLSSQTLRASSSAGTDPQLLLYRVVRGPQLGRLFH------AQQDSTGEAL 1643
V G L+ Q L T LL V P G L ++ +G +
Sbjct: 1078 FIVYEGEKNSLTLQHLHV-EDVDTHQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPI 1136
Query: 1644 VNFTQAEVYAGNILYEHEM-----PPEPFWEAHDTLELQLSSPPARDVAATLAVAVSFEA 1698
F+ ++ +I Y + P E + + + + S +V + + + +
Sbjct: 1137 SAFSLRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSP----NVFFPIIILPTNDE 1192
Query: 1699 ACPQRPSHLWKNKGLWVPEGQRARITVAALDASNLLASVPSPQRSEHDVLFQVTQFPSRG 1758
P+ +H +K V EG I L+ ++ A +P +++ FQ+T P G
Sbjct: 1193 Q-PKLFAHEFK-----VLEGMSLVIDTQLLNGAD--ADLP-----PNELHFQLTALPRHG 1239
Query: 1759 ----QLLVSEEPLHAGQPHFLQSQLAAGQLVYAHGGGGTQQDGFHFRAHLQGPAGASVAG 1814
QL +P+H+ L+ A +VY H T++D F S
Sbjct: 1240 RIIQQLATGSQPIHS---FTLKEIQEASTIVYEHDDSETKEDSFE--------VWLSDGK 1288
Query: 1815 PQTSEAFAITVRDVNERPPQPQASVPLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQR 1874
T I V V++ P + L++ +G I+ L D DS + + +
Sbjct: 1289 HTTHRKVPIVVTLVDDETPHLTVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHS 1348
Query: 1875 APHNGFLSLVGGGLGPV-------TRFTQADVDSGRLAFVANG-SSVAGIFQLSMSDGAS 1926
P G L + G V FTQ +++ G + ++ G + I + ++DG +
Sbjct: 1349 GPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGVN 1408
Query: 1927 PPLPMSLAVDI--LPSAIEVQLRAPLEVPQALGRSSLSQQQLRVVSDREEPEAAYRLIQG 1984
V I L S + + + + R +L+ L E + + +
Sbjct: 1409 TLTDHYFYVTIGNLDSVFPEVISKRITLIEG-ARVTLTNNLLTNSDINSSDEHHFSITRA 1467
Query: 1985 PQYGHLL---VGGRPTSAFSQFQIDQGEVVFAFT-NFSSSHDHFRVLALARGVNASAVVN 2040
P GHL G P ++F+Q Q+ ++ + T N D F +
Sbjct: 1468 PSLGHLESSDYAGEPIASFTQLQLASNKISYVHTSNDEKKMDSFEFQVIGELYPVFRTFR 1527
Query: 2041 VTVRALLHVWAGGPWPQGATLRLDPTVLDAGELANRTGSVP----RFRLLEGPRHGRVVR 2096
+ + + + + + D ++ EL P F + + P HG+++
Sbjct: 1528 IFITDVDNKKPILTIHRLTLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKILY 1587
Query: 2097 VPRARTEPGGSQLVEQFTQQDL 2118
GS+ V FT+QDL
Sbjct: 1588 --------NGSRPVTTFTKQDL 1601
Score = 90.5 bits (223), Expect = 2e-17
Identities = 243/1107 (21%), Positives = 413/1107 (37%), Gaps = 223/1107 (20%)
Query: 1172 PRWGQLVRA-GQPATAFSQQD---LLDGAVLYSHNGSLSP-RDTMAFSVEA-GPVHTDAT 1225
P++G+LV A G P D L V Y H + SP RD + VE GP DA
Sbjct: 221 PKYGRLVDAVGAPLPRGKGVDCEAFLRAGVRYQHTATSSPNRDYVPMMVELLGPEGQDAG 280
Query: 1226 ---------LQVTIALEG-----PLAPLKLVRHKKIYVFQGEAAEIRRDQLEAAQEAVPP 1271
Q+ + + G P P + + V + D L A P
Sbjct: 281 SAGVLVREHFQLLVRIRGGAENTPPRP-SFMATMMMEVDPLVLTALTPDALAAEDVESDP 339
Query: 1272 ADIVFSVKSPPS--------AGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLYLHS 1323
D+VF++ + P+ GY+V D+P L PV F+Q+ + ++ Y
Sbjct: 340 GDLVFNILNAPTHPPGHPGQQGYVVST------DDPLGL-PVSFFTQQELRELKIAYQPP 392
Query: 1324 RPEAWSDAF---SLDVASGLGAPLE--GVLVELEVLPAAIPLEAQNFSVP--EGGSLTLA 1376
+ + L+V G GA + +V ++ + +P+ + N + EG S L+
Sbjct: 393 AENSHGERLFQLELEVVDGDGAASDPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSRPLS 452
Query: 1377 PP-LLRVSGPYFPTLLGLSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVHD 1435
+ +S L + + + +HG L P F+ + + Y HD
Sbjct: 453 STHSIPISDK--DNLEEVKMAAVRGLRHGQLVVFGAPAG--CKYFTPADLAAGRVVYQHD 508
Query: 1436 GSETLTDSFVLMANASEMDRQSHPV--AFTVTVLPVNDQPPILTTNTGLQMWEGATAPIP 1493
GS T +D+ + M+ H V F +T+LPV+D+PP++ TNTGL + EG I
Sbjct: 509 GSNTYSDNIIF-----RMEDGHHQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQIS 563
Query: 1494 AEALRSTDGDSGSEDLVYTIE-QPSNG---RVVLRGAPGTE------------------- 1530
L +TD DS + + +E QP G APG+
Sbjct: 564 PFVLSATDIDSEDSTIHFVLENQPLKGNEEEPQWELAPGSSHSGHYLGDLLLQQAELPLS 623
Query: 1531 ------------------VRSFTQAQLDGGLVLFSHRG-----TLDGGFRFRLSDGEHTS 1567
V + Q + G + + H G ++ F + D +H
Sbjct: 624 TEDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHVQD-DHDP 682
Query: 1568 PG----HFFRVTAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASS---------SAGTD 1614
P H F + Q +LS + + PG+ ++ Q + + +D
Sbjct: 683 PNLSKQHIFTIKVQPVDILSPQ------LYPGTTLEMTVQEYQLTHFQKNFLRYIDQDSD 736
Query: 1615 PQLLLYRVVRGP-------QLGRLFHAQQDSTGEALVNFTQAEVYAGNILYEHEMPPEPF 1667
Q L Y ++ P Q+ DS +++FTQA+V + Y+ PP+
Sbjct: 737 DQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQVNQHKVAYQ---PPQKL 793
Query: 1668 WEAHDTLEL--QLSSPPARDVAATLAVAVSFEAACPQRPSHLWKNKGLWVPEGQRARITV 1725
A ++ Q+ V T + F +P + N+G + EG
Sbjct: 794 GIAPRVVQFTYQVEDAAGNSVPGTFTL---FLQPVDNQPPEV-TNRGFAILEG------- 842
Query: 1726 AALDASNLLASVPSPQRSEHDVLFQVTQFPSRGQLLVSEEPLHAGQPHFLQSQLAAGQLV 1785
+ + S+ V P ++F + + P G L + + G+ F+Q+ + G +
Sbjct: 843 GSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKRCMVPGE-SFMQADVINGSVS 901
Query: 1786 YAHG-GGGTQQDGFHFRA-----HLQGPAGASVAGPQTSEAFAITVR-----DVNERPPQ 1834
Y HG T D FH H+ SV + + I++R DV+ +
Sbjct: 902 YQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVLE 961
Query: 1835 PQAS-VPLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTR 1893
+A+ + + + G R + LS + DS P G +++ GL P R
Sbjct: 962 NKATEITMGVIHGKRKDVGDLMLSFIVKDS------------PKLG--TILVNGL-PTER 1006
Query: 1894 FTQADVDSGRLAFVANGSSVA-----GIFQLSMSD-------GASPPLPMSLAVDILP-- 1939
FTQ D+ +GR+A+ V F L +S G S + + V +LP
Sbjct: 1007 FTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVD 1066
Query: 1940 -SAIEVQLRAPLEVPQALGRSSLSQQQLRVVS-DREEPEAAYRLIQGPQYGHL------- 1990
+V + V + ++SL+ Q L V D + E + P G+L
Sbjct: 1067 NVGPKVFVGESFIVYEG-EKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEKIASAP 1125
Query: 1991 ----LVGGRPTSAFSQFQIDQGEVVFA---FTNFSSSHDHFRVLALARGVNASAVVNVTV 2043
G P SAFS I + + D F + G+N S V +
Sbjct: 1126 GSKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQEDQF-TFYCSDGINFSPNVFFPI 1184
Query: 2044 ----------RALLHVWAGGPWPQGATLRLDPTVLDAGELANRTGSVPRFRLLEGPRHGR 2093
+ H + +G +L +D +L+ + A+ + F+L PRHGR
Sbjct: 1185 IILPTNDEQPKLFAHEF---KVLEGMSLVIDTQLLNGAD-ADLPPNELHFQLTALPRHGR 1240
Query: 2094 VVRVPRARTEPGGSQLVEQFTQQDLED 2120
+++ GSQ + FT +++++
Sbjct: 1241 IIQQLAT-----GSQPIHSFTLKEIQE 1262
Score = 89.7 bits (221), Expect = 3e-17
Identities = 202/865 (23%), Positives = 324/865 (37%), Gaps = 109/865 (12%)
Query: 421 LPPVFANFTQLLTISPLVVAEGGTAWLE---WRHVQPTLDLMEAELRKSQVLFSVTRGAR 477
+P F F Q + P V G A LE + L + + + Q++F + RG +
Sbjct: 814 VPGTFTLFLQPVDNQPPEVTNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQ 873
Query: 478 HGELELDIPGAQARKMFTLLDVVNRKARFIHDGSE-DTSDQLVLEVS-VTARVPMPSCLR 535
HG L+ + F DV+N + H + TSD LEVS +P+
Sbjct: 874 HGHLQYFKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVHHIPI----- 928
Query: 536 RGQTYLLPIQVNP--VNDPPHIIFPHGSLM----VILEHTQKPLGPEVFQAYDPDSACEG 589
+PI V+P N P I SL+ +LE+ + V D
Sbjct: 929 -----TIPISVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLM 983
Query: 590 LTFQV-----LGT--SSGLPVERRDQPGEPATEFSCRELEAGSLVYVHRGGPA----QDL 638
L+F V LGT +GLP ER F+ +L G + Y H G Q
Sbjct: 984 LSFIVKDSPKLGTILVNGLPTER----------FTQEDLINGRVAYAHTAGEVGFQKQHD 1033
Query: 639 TFRV---SDGLQ-----------ASPPATLKVVAIRPAIQIHRSTGLRLAQGSAMPILPA 684
F + D Q L V + P + + S + +G +
Sbjct: 1034 AFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVFVGES--FIVYEGEKNSLTLQ 1091
Query: 685 NLSVETNAVGQDVSVLFRVTGALQFGELQK--QGAGGVEGAEWWATQAFHQRDVEQGRVR 742
+L VE QD +L VT G L+K G AF RD++ +
Sbjct: 1092 HLHVEDVDTHQD-ELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHIN 1150
Query: 743 YLST-----DPQHHAYDTVENLALEVQVGQEILSNLSFPVTIQRATVWMLRLEPLHTQNT 797
Y+ + +PQ + G N+ FP+ I +L +
Sbjct: 1151 YVQSIHKGVEPQE------DQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVL 1204
Query: 798 QQETLTTAHLEATLEEAGPSPPTFHYEVVQAPRKGN-LQLQGTRLSDGQGFTQDDIQ-AG 855
+ +L +A P H+++ PR G +Q T FT +IQ A
Sbjct: 1205 EGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEIQEAS 1264
Query: 856 RVTYGATARASEAVEDTFRFRVTAPPYFSPLYTFPIHIGGDPDAPVLT-NVLLVVPEGGE 914
+ Y SE ED+F ++ + + + D + P LT N L V +G
Sbjct: 1265 TIVY--EHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKGHS 1322
Query: 915 GVLSADHLFVKSLNS--ASYLYEVMERPRHGRLAW----RG-TQDKTTMVTSFTNEDLLR 967
+++ L L+S S + + P+ G L RG ++ T+ +FT +++ R
Sbjct: 1323 EIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEINR 1382
Query: 968 GRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGVFRVAIQPVNDHAPVQTISRIF 1027
G + Y H E D I F T + D F V I ++ P + IS+
Sbjct: 1383 GLICYIHTGQEGIVDIIKFDVTDGVNTLTD-------HYFYVTIGNLDSVFP-EVISKRI 1434
Query: 1028 HVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIVAVDEPTRPIYRFTQEDLR 1087
+ G R LT + + SD +S + +TR L G + + D PI FTQ L
Sbjct: 1435 TLIEGARVTLTNNLLTNSDINSS-DEHHFSITRAPSL-GHLESSDYAGEPIASFTQLQLA 1492
Query: 1088 KRRVLFVHSGADR---GWIQLQVSDGQHQA-----TALLEVQASEPYLRVANGSSLVVPQ 1139
++ +VH+ D + QV + + +V +P L + L + +
Sbjct: 1493 SNKISYVHTSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTI---HRLTLQK 1549
Query: 1140 GGQGTIDTAVLHLDTNLDIRSGDEVHYHVTAGPRWGQLVRAG-QPATAFSQQDLLDGAVL 1198
I +L L D + + +T P G+++ G +P T F++QDL +
Sbjct: 1550 EDSQLI--TLLELTVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLIS 1607
Query: 1199 YSHNGSLSPRDTMAFSVEAGPVHTD 1223
Y H+GS + D+ + +V G HTD
Sbjct: 1608 YKHDGSETTEDSFSLTVTDG-THTD 1631
Score = 43.9 bits (102), Expect = 0.002
Identities = 43/150 (28%), Positives = 64/150 (42%), Gaps = 17/150 (11%)
Query: 437 LVVAEGGTAWLEWRHVQPTLDLMEAELRKSQVLFSVTRGARHGELELDIPGAQAR-KMFT 495
LV+ EG + L H P D E +V + RG RHG+L + GA A K FT
Sbjct: 441 LVLFEGQSRPLSSTHSIPISDKDNLE----EVKMAAVRGLRHGQLV--VFGAPAGCKYFT 494
Query: 496 LLDVVNRKARFIHDGSEDTSDQLVLEVSVTARVPMPSCLRRGQTYLLPIQVNPVNDPPHI 555
D+ + + HDGS SD ++ + +L P+ + PV+D P +
Sbjct: 495 PADLAAGRVVYQHDGSNTYSDNIIFRMEDG---------HHQVDFLFPLTILPVDDEPPM 545
Query: 556 IFPHGSLMVILEHTQKPLGPEVFQAYDPDS 585
+ + L + E + P V A D DS
Sbjct: 546 VNTNTGLS-LTEGQVVQISPFVLSATDIDS 574
Score = 42.7 bits (99), Expect = 0.004
Identities = 61/237 (25%), Positives = 88/237 (37%), Gaps = 45/237 (18%)
Query: 847 FTQDDIQAGRVTYGATARASE----------------AVEDTFRFRVTAPPYFSPLYTFP 890
FTQ +++ ++ Y A S A D F F VT + L
Sbjct: 377 FTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAASDPFAFMVTVKS-MNTLVPVA 435
Query: 891 IHIGGDPDAPVLTNVLLVVPEGGEGVLSADHLFVKSLNSASYLYEV----MERPRHGRLA 946
H G LV+ EG LS+ H ++ L EV + RHG+L
Sbjct: 436 SHNRG-----------LVLFEGQSRPLSSTHSI--PISDKDNLEEVKMAAVRGLRHGQLV 482
Query: 947 WRGTQDKTTMVTSFTNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGV 1006
G FT DL GR+VYQHD S T D+I F G D +
Sbjct: 483 VFGAPAGCKY---FTPADLAAGRVVYQHDGSNTYSDNIIF-RMEDGHHQVDF-------L 531
Query: 1007 FRVAIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDL 1063
F + I PV+D P+ + + G ++ ++ +D DS + VL + L
Sbjct: 532 FPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPL 588
>gi|122056683 FRAS1 related extracellular matrix 1 [Homo sapiens]
Length = 2179
Score = 192 bits (489), Expect = 2e-48
Identities = 329/1385 (23%), Positives = 555/1385 (40%), Gaps = 188/1385 (13%)
Query: 647 QASPPATLKV---VAIRPAIQIHRSTGLRLAQGSAMPILPANLSVETNAVGQDVSVLFRV 703
+ S P T+ + A A ++ +TGL L +G + I V N D+ + V
Sbjct: 395 ERSAPMTVHISIRTADTNAPRVSWNTGLSLLEGQSRAITWEQFQVVDN---DDIGAVRLV 451
Query: 704 T-GALQFGELQKQGAGGVEGAEWWATQAFHQRDVEQGRVRYLSTDPQHHAYDTVENLALE 762
T G LQ G L +G G F D++ G VRY D T + +
Sbjct: 452 TVGGLQHGWLTLRGGKGF---------LFTVADLQAGVVRYHHDDSD----STKDFVVFR 498
Query: 763 VQVGQEILSNLSFPVTIQRA--------TVWMLRLEPLHTQNTQQETLTTAHLEATLEEA 814
+ G + + FP+ + T ++ LE T Q L + ++A
Sbjct: 499 IFDGHHSIRH-KFPINVLPKDDSPPFLITNVVIELEEGQTILIQGSMLRASDVDA----- 552
Query: 815 GPSPPTFHYEVVQAPRKGNLQLQ---GTRLSDGQGFTQDDIQAGRVTYGATARASEAVED 871
S + + + P+ G + + G GF Q D+ G + Y E ED
Sbjct: 553 --SDDYIFFNITKPPQAGEIMKKPGPGLIGYPVHGFLQRDLFNGIIYYRHFG--GEIFED 608
Query: 872 TFRFRVT---APPYFSPLYTFPIHIGGDPD-----APVLTNVLLVVPEGGEGVLSADHLF 923
+F+F + PP S IHI D AP ++ L VV E ++ L
Sbjct: 609 SFQFVLWDSHEPPNLSVPQVATIHITPVDDQLPKEAPGVSRHL-VVKETEVAYITKKQLH 667
Query: 924 VKSLNSASY----LYEVMERP------RH---GRLAWRGTQDKTTM------VTSFTNED 964
++S SY +Y + P RH G+L + K + SFT
Sbjct: 668 F--IDSESYDRELVYTITTPPFFSFSHRHLDAGKLFMVDSIPKVVKNPTALELRSFTQHA 725
Query: 965 LLRGRLVYQHDDSETTED--DIPFVATRQGESSGDMAWEEVRGV-FRVAIQPVNDHAPVQ 1021
+ ++ Y + D+ F + + G + G+ F + I PV++ P +
Sbjct: 726 VNYMKVAYMPPMQDIGPHCRDVQFTFSVSNQHGGTL-----HGICFNITILPVDNQVP-E 779
Query: 1022 TISRIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIVAVDEPTRPIYRF 1081
+ V GG+ +++T+ + SDAD+ + L L R+ L G + P F
Sbjct: 780 AFTNPLKVTEGGQSIISTEHILISDADTKLDNIDLSL-RELPLHGRVELNGFPLNSGGTF 838
Query: 1082 TQEDLRKRRVLFVHSGAD--RGWIQLQVSDGQHQATALLEVQA-----SEPYLRVANGSS 1134
+ DL +V + H G + + + L+V+DG + A +L V+ P L+
Sbjct: 839 SWGDLHTLKVRYQHDGTEVLQDDLLLEVTDGTNSAEFVLHVEVFPVNDEPPVLKADLMPV 898
Query: 1135 LVVPQGGQGTIDTAVLHLDTNLDIRSGD-EVHYHVTAGPRWGQLVRAGQPATAFSQQDLL 1193
+ +GG+ I + + D+ S + ++ + + P+ G + RAG FSQ+D++
Sbjct: 899 MNCSEGGEVVITSEYIFAT---DVDSDNLKLMFVIAREPQHGVVRRAGVTVDQFSQRDVI 955
Query: 1194 DGAVLYSHNG---SLSP-RDTMAFSV---EAGP-----VHTDATLQVTIALEGPLAPLKL 1241
AV Y H G L P DT+ V EAGP + V + P+ L +
Sbjct: 956 SEAVTYKHTGGEIGLMPCFDTITLVVSDGEAGPFVNGCCYNGPNPSVPLHASFPVYDLNI 1015
Query: 1242 VRH------------KKIYVFQGEAAEIRRDQLEAAQEAVPPADIVFSVKSPPSAGYL-- 1287
+ V +G + + + L A D+ F + SPP GYL
Sbjct: 1016 TVYPVDNQPPSIAIGPVFVVDEGCSTALTVNHLSATDPDTAADDLEFVLVSPPQFGYLEN 1075
Query: 1288 VMVSRG-ALADEPPSLDPVQSFSQEAVDTGRVLYLHSRPEAWSDAFSLDVASGLGAPLEG 1346
++ S G ++ S+D Q A V H R E +D F++ V G LE
Sbjct: 1076 ILPSVGFEKSNIGISIDSFQWKDMNAFHINYVQSRHLRIEPTADQFTVYVTDGKHHSLE- 1134
Query: 1347 VLVELEVLPA---AIPLEAQNFSVPEGGSLTLAPPLLRVSGPYFPTLLGLSLQVLEPPQH 1403
+ + + P A QN +V EG L ++ P L + + P+H
Sbjct: 1135 IPFSIIINPTNDEAPDFVVQNITVCEGQMKELDSSIISAVDLDIPQ-DALLFSITQKPRH 1193
Query: 1404 GAL------------QKEDGPQAR--TLSAFSWRMVEEQL-IRYVHDGSETLTDSFVLMA 1448
G L ++ P + + +FS +++ + + Y+HD SE+L D F +
Sbjct: 1194 GLLIDRGFSKDFSENKQPANPHQKHAPVHSFSMELLKTGMRLTYMHDDSESLADDFTI-- 1251
Query: 1449 NASEMDRQSHPVAFTVT--VLPVNDQPPILTTNTGLQMWEGATAPIPAEALRSTDGDSGS 1506
++ H + T++ V+PVND+ P+L+ + M G T I + L + D DS
Sbjct: 1252 ---QLSDGKHKILKTISVEVIPVNDEKPMLSKKAEIAMNMGETRIISSAILSAIDEDSPR 1308
Query: 1507 EDLVYTIEQ-PSNGRVVLR----GAPGTEVRSFTQAQLDGGLVLFSHRGTLDG----GFR 1557
E + Y E+ P NG++ L+ P + TQ ++D L+ ++H G +D F
Sbjct: 1309 EKIYYVFERLPQNGQLQLKIGRDWVPLSPGMKCTQEEVDLNLLRYTHTGAMDSQNQDSFT 1368
Query: 1558 FRLSDGEHTSPGHFFRVT---AQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASSSAGTD 1614
F L DG + SP ++T +K ++ L ++ L V G L++ TL A GTD
Sbjct: 1369 FYLWDGNNRSPALDCQITIKDMEKGDIVIL--TKPLVVSKGDRGFLTTTTLLAVD--GTD 1424
Query: 1615 -PQLLLYRVVRGPQLGRLFHAQQDSTGEALVNFTQAEVYAGNILYEHEMPPEPFWEAHDT 1673
P+ LLY + P+ G++ + G + NF+Q +V + Y H+ + D
Sbjct: 1425 KPEELLYVITSPPRYGQIEYVHY--PGVPITNFSQMDVVGQTVCYVHK---SKVTVSSDR 1479
Query: 1674 LELQLSSPPARDVAATLAVAVSFEAACPQRPSHLWKNKGLWVPEGQRARITVAALDASNL 1733
+S+ + + + A P + +NKGL + +G V L
Sbjct: 1480 FRFIISNGLRTEHGVFEITLETVDRALPV----VTRNKGLRLAQG-----AVGLLSPD-- 1528
Query: 1734 LASVPSPQRSEHDVLFQVTQFPSRGQLLVSEEPLHAGQPHFLQSQLAAGQLVYAHGGGGT 1793
L + P ++ F + Q P GQL + L Q +F Q + + + Y H GG +
Sbjct: 1529 LLQLTDPDTPAENLTFLLVQLPQHGQLYLWGTGLL--QHNFTQQDVDSKNVAYRHSGGDS 1586
Query: 1794 QQDGFHFRAHLQGPAGASVAGPQTSE--AFAITVRDVNERPPQ-----PQASVPLRLTRG 1846
Q D F F A G V G E F I V +++ P+ + V L
Sbjct: 1587 QTDCFTFMATDGTNQGFIVNGRVWEEPVLFTIQVDQLDKTAPRITLLHSPSQVGLLKNGC 1646
Query: 1847 SRAPISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQADVDSGRLAF 1906
I+ L DPD+ +I +++ + P +G L G +F+Q D++S + +
Sbjct: 1647 YGIYITSRVLKASDPDTEDDQIIFKILQGPKHGHLENTTTGEFIHEKFSQKDLNSKTILY 1706
Query: 1907 VANGS 1911
+ N S
Sbjct: 1707 IINPS 1711
Score = 176 bits (446), Expect = 2e-43
Identities = 303/1286 (23%), Positives = 510/1286 (39%), Gaps = 180/1286 (13%)
Query: 952 DKTTMVTSFTNEDLLRGRLVYQHDDSETTE---DDIPF-VATRQGESSGDMAWEEVRGVF 1007
D T ++SFT +DL ++ YQ +S +E D++ V E S M
Sbjct: 350 DHTRPISSFTWKDLSDMQIAYQPPNSSHSERRHDEVELEVYDFFFERSAPMT-------V 402
Query: 1008 RVAIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGS 1067
++I+ + +AP + + + G R +T + F D+ A ++T L G
Sbjct: 403 HISIRTADTNAPRVSWNTGLSLLEGQSRAITWEQ--FQVVDNDDIGAVRLVTVGGLQHGW 460
Query: 1068 IVAVDEPTRPIYRFTQEDLRKRRVLFVHSGAD--RGWIQLQVSDGQHQATALLEVQA--- 1122
+ + FT DL+ V + H +D + ++ ++ DG H +
Sbjct: 461 LTLRGGKG---FLFTVADLQAGVVRYHHDDSDSTKDFVVFRIFDGHHSIRHKFPINVLPK 517
Query: 1123 --SEPYLRVANGSSLVVPQGGQGTIDTAVLHLDTNLDIRSGDEVHYHVTAGPRWGQLVRA 1180
S P+L + ++ + GQ + + +++D S D + +++T P+ G++++
Sbjct: 518 DDSPPFLIT---NVVIELEEGQTILIQGSMLRASDVDA-SDDYIFFNITKPPQAGEIMKK 573
Query: 1181 ------GQPATAFSQQDLLDGAVLYSHNGSLSPRDTMAFSVEAG------PVHTDATLQV 1228
G P F Q+DL +G + Y H G D+ F + V AT+ +
Sbjct: 574 PGPGLIGYPVHGFLQRDLFNGIIYYRHFGGEIFEDSFQFVLWDSHEPPNLSVPQVATIHI 633
Query: 1229 T-IALEGPLAPLKLVRHKKIYVFQGEAAEIRRDQLEAAQEAVPPADIVFSVKSPP----- 1282
T + + P + RH + V + E A I + QL ++V+++ +PP
Sbjct: 634 TPVDDQLPKEAPGVSRH--LVVKETEVAYITKKQLHFIDSESYDRELVYTITTPPFFSFS 691
Query: 1283 ----SAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLYLHSR----PEAWSDAFSL 1334
AG L MV + P+ ++SF+Q AV+ +V Y+ P F+
Sbjct: 692 HRHLDAGKLFMVDSIPKVVKNPTALELRSFTQHAVNYMKVAYMPPMQDIGPHCRDVQFTF 751
Query: 1335 DVASGLGAPLEGVLVELEVLPA--AIPLEAQN-FSVPEGGSLTLAPPLLRVSGPYFPTLL 1391
V++ G L G+ + +LP +P N V EGG ++ + +S L
Sbjct: 752 SVSNQHGGTLHGICFNITILPVDNQVPEAFTNPLKVTEGGQSIISTEHILISDAD-TKLD 810
Query: 1392 GLSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVHDGSETLTDSFVLMANAS 1451
+ L + E P HG ++ P + FSW + +RY HDG+E L D +L
Sbjct: 811 NIDLSLRELPLHGRVELNGFP-LNSGGTFSWGDLHTLKVRYQHDGTEVLQDDLLLEVTDG 869
Query: 1452 EMDRQSHPVAFTVTVLPVNDQPPILTTNTG--LQMWEGATAPIPAEALRSTDGDSGSEDL 1509
S V V PVND+PP+L + + EG I +E + +TD DS + L
Sbjct: 870 T---NSAEFVLHVEVFPVNDEPPVLKADLMPVMNCSEGGEVVITSEYIFATDVDSDNLKL 926
Query: 1510 VYTIEQPSNGRVVLRGAPGTEVRSFTQAQLDGGLVLFSHRGTLDG------GFRFRLSDG 1563
++ I + VV R G V F+Q + V + H G G +SDG
Sbjct: 927 MFVIAREPQHGVVRRA--GVTVDQFSQRDVISEAVTYKHTGGEIGLMPCFDTITLVVSDG 984
Query: 1564 E---------HTSPGHFFRVTAQKQVLLSLKGSQTLTVCPGSVQPLS------------- 1601
E + P + A V +TV P QP S
Sbjct: 985 EAGPFVNGCCYNGPNPSVPLHASFPVY-----DLNITVYPVDNQPPSIAIGPVFVVDEGC 1039
Query: 1602 SQTLRASSSAGTDPQL----LLYRVVRGPQLGRLFHA------QQDSTGEALVNFTQAEV 1651
S L + + TDP L + +V PQ G L + ++ + G ++ +F ++
Sbjct: 1040 STALTVNHLSATDPDTAADDLEFVLVSPPQFGYLENILPSVGFEKSNIGISIDSFQWKDM 1099
Query: 1652 YAGNILY--EHEMPPEPFWEAHDTLELQLSSPPARDVAATLAVAVSFEAACPQRPSHLWK 1709
A +I Y + EP D + ++ + ++ ++ + P + +
Sbjct: 1100 NAFHINYVQSRHLRIEP---TADQFTVYVTDGKHHSLEIPFSIIIN--PTNDEAPDFVVQ 1154
Query: 1710 NKGLWVPEGQRARITVAALDASNLLASVPSPQRSEHDVLFQVTQFPSRGQLL-------- 1761
N + V EGQ + + + A +L +P + +LF +TQ P G L+
Sbjct: 1155 N--ITVCEGQMKELDSSIISAVDL--DIP-----QDALLFSITQKPRHGLLIDRGFSKDF 1205
Query: 1762 -VSEEPLHAGQPH-----FLQSQLAAG-QLVYAHGGGGTQQDGFHFRAHLQGPAGASVAG 1814
+++P + Q H F L G +L Y H + D F + S
Sbjct: 1206 SENKQPANPHQKHAPVHSFSMELLKTGMRLTYMHDDSESLADDFTIQL--------SDGK 1257
Query: 1815 PQTSEAFAITVRDVNERPPQPQASVPLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQR 1874
+ + ++ V VN+ P + + G IS A LS +D DS +I Y +R
Sbjct: 1258 HKILKTISVEVIPVNDEKPMLSKKAEIAMNMGETRIISSAILSAIDEDSPREKIYYVFER 1317
Query: 1875 APHNGFLSLVGG----GLGPVTRFTQADVDSGRLAFVANG---SSVAGIFQLSMSDG--A 1925
P NG L L G L P + TQ +VD L + G S F + DG
Sbjct: 1318 LPQNGQLQLKIGRDWVPLSPGMKCTQEEVDLNLLRYTHTGAMDSQNQDSFTFYLWDGNNR 1377
Query: 1926 SPPLPMSLAVDILPSAIEVQLRAPLEVPQALGRSSLSQQQLRVVSDREEP-EAAYRLIQG 1984
SP L + + + V L PL V + R L+ L V ++P E Y +
Sbjct: 1378 SPALDCQITIKDMEKGDIVILTKPLVVSKG-DRGFLTTTTLLAVDGTDKPEELLYVITSP 1436
Query: 1985 PQYG---HLLVGGRPTSAFSQFQIDQGEVVFAF-TNFSSSHDHFRVLALARGVNAS-AVV 2039
P+YG ++ G P + FSQ + V + + + S D FR + ++ G+ V
Sbjct: 1437 PRYGQIEYVHYPGVPITNFSQMDVVGQTVCYVHKSKVTVSSDRFRFI-ISNGLRTEHGVF 1495
Query: 2040 NVTV----RALLHVW--AGGPWPQGATLRLDPTVLDAGELANRTGSVPRFRLLEGPRHGR 2093
+T+ RAL V G QGA L P +L + ++ F L++ P+HG+
Sbjct: 1496 EITLETVDRALPVVTRNKGLRLAQGAVGLLSPDLLQLTDPDTPAENL-TFLLVQLPQHGQ 1554
Query: 2094 VVRVPRARTEPGGSQLVEQFTQQDLE 2119
+ G L FTQQD++
Sbjct: 1555 LYLW-------GTGLLQHNFTQQDVD 1573
Score = 148 bits (374), Expect = 5e-35
Identities = 302/1338 (22%), Positives = 531/1338 (39%), Gaps = 197/1338 (14%)
Query: 475 GARHGELELDIPGAQARKMFTLLDVVNRKARFIHDGSEDTSDQLVLEVSVTARVPMPSCL 534
G +HG L L G + +FT+ D+ R+ HD S+ T D +V +
Sbjct: 455 GLQHGWLTLR--GGKGF-LFTVADLQAGVVRYHHDDSDSTKDFVVFRIFDG--------- 502
Query: 535 RRGQTYLLPIQVNPVNDPPHIIFPHGSLMVILEHTQKPL-GPEVFQAYDPDSACEGLTFQ 593
+ PI V P +D P + + +++ LE Q L + +A D D++ + + F
Sbjct: 503 HHSIRHKFPINVLPKDDSPPFLITN--VVIELEEGQTILIQGSMLRASDVDASDDYIFFN 560
Query: 594 VLGTSSGLPVERRDQPG---EPATEFSCRELEAGSLVYVHRGGPAQDLTFRVSDGLQASP 650
+ + ++ PG P F R+L G + Y H GG + +F+ P
Sbjct: 561 ITKPPQAGEIMKKPGPGLIGYPVHGFLQRDLFNGIIYYRHFGGEIFEDSFQFVLWDSHEP 620
Query: 651 P-------ATLKVVAI-------RPAIQIHRSTGLRLAQGSAMPILPANLSVETNAVGQD 696
P AT+ + + P + H L + + I L ++ D
Sbjct: 621 PNLSVPQVATIHITPVDDQLPKEAPGVSRH----LVVKETEVAYITKKQLHF-IDSESYD 675
Query: 697 VSVLFRVTGALQFGELQKQGAGG-----------VEGAEWWATQAFHQRDVEQGRVRYLS 745
+++ +T F + G V+ ++F Q V +V Y+
Sbjct: 676 RELVYTITTPPFFSFSHRHLDAGKLFMVDSIPKVVKNPTALELRSFTQHAVNYMKVAYMP 735
Query: 746 T--DPQHHAYDTVENLALEVQVGQEILSNLSFPVTIQRAT--VWMLRLEPLHTQNTQQET 801
D H D ++ Q G L + F +TI V PL Q
Sbjct: 736 PMQDIGPHCRDVQFTFSVSNQHGGT-LHGICFNITILPVDNQVPEAFTNPLKVTEGGQSI 794
Query: 802 LTTAHLEATLEEAGPSPPTFHYEVVQAPRKGNLQLQGTRLSDGQGFTQDDIQAGRVTYGA 861
++T H+ + +A + + P G ++L G L+ G F+ D+ +V Y
Sbjct: 795 ISTEHI--LISDADTKLDNIDLSLRELPLHGRVELNGFPLNSGGTFSWGDLHTLKVRYQH 852
Query: 862 TARASEAVEDTFRFRVT----APPYFSPLYTFPIHIGGDPDAPVLTNVLLVV---PEGGE 914
+E ++D VT + + + FP++ + PVL L+ V EGGE
Sbjct: 853 DG--TEVLQDDLLLEVTDGTNSAEFVLHVEVFPVN----DEPPVLKADLMPVMNCSEGGE 906
Query: 915 GVLSADHLFVKSLNSASY--LYEVMERPRHGRLAWRGTQDKTTMVTSFTNEDLLRGRLVY 972
V++++++F ++S + ++ + P+HG + G V F+ D++ + Y
Sbjct: 907 VVITSEYIFATDVDSDNLKLMFVIAREPQHGVVRRAGVT-----VDQFSQRDVISEAVTY 961
Query: 973 QHDDSET----TEDDIPFVATRQGES---------SGDMAWEEVRGVF-----RVAIQPV 1014
+H E D I V + GE+ +G + F + + PV
Sbjct: 962 KHTGGEIGLMPCFDTITLVVS-DGEAGPFVNGCCYNGPNPSVPLHASFPVYDLNITVYPV 1020
Query: 1015 NDHAPVQTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIVAVDEP 1074
++ P I +F V G LT + ++ +D D+ D + VL FG + +
Sbjct: 1021 DNQPPSIAIGPVFVVDEGCSTALTVNHLSATDPDTAADDLEFVLVSPPQ-FGYLENILPS 1079
Query: 1075 TR--------PIYRFTQEDLRKRRVLFVHSGADR-----GWIQLQVSDGQHQATALLEVQ 1121
I F +D+ + +V S R + V+DG+H + LE+
Sbjct: 1080 VGFEKSNIGISIDSFQWKDMNAFHINYVQSRHLRIEPTADQFTVYVTDGKHHS---LEI- 1135
Query: 1122 ASEPYLRVANGSS----------LVVPQGGQGTIDTAVLHLDTNLDIRSGDEVHYHVTAG 1171
P+ + N ++ + V +G +D++++ +LDI D + + +T
Sbjct: 1136 ---PFSIIINPTNDEAPDFVVQNITVCEGQMKELDSSIISA-VDLDIPQ-DALLFSITQK 1190
Query: 1172 PRWGQLVRAG---------QPAT---------AFSQQDLLDGAVL-YSHNGSLSPRDTMA 1212
PR G L+ G QPA +FS + L G L Y H+ S S D
Sbjct: 1191 PRHGLLIDRGFSKDFSENKQPANPHQKHAPVHSFSMELLKTGMRLTYMHDDSESLADDFT 1250
Query: 1213 FSVEAGPVHTDATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEIRRDQLEAAQEAVPPA 1272
+ G T+ V + P+ L + +I + GE I L A E P
Sbjct: 1251 IQLSDGKHKILKTISVEVIPVNDEKPM-LSKKAEIAMNMGETRIISSAILSAIDEDSPRE 1309
Query: 1273 DIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLYLHS--RPEAWSD 1330
I + + P G L + + + L P +QE VD + Y H+ D
Sbjct: 1310 KIYYVFERLPQNGQLQL----KIGRDWVPLSPGMKCTQEEVDLNLLRYTHTGAMDSQNQD 1365
Query: 1331 AFSLDVASG--LGAPLEGVLVELEVLPAAIPLEAQNFSVPEG--GSLTLAPPLLRVSGPY 1386
+F+ + G L+ + ++ I + + V +G G LT LL V G
Sbjct: 1366 SFTFYLWDGNNRSPALDCQITIKDMEKGDIVILTKPLVVSKGDRGFLTTTT-LLAVDGTD 1424
Query: 1387 FPTLLGLSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVHDGSETLTDSFVL 1446
P L + PP++G ++ P ++ FS V Q + YVH T++
Sbjct: 1425 KPE--ELLYVITSPPRYGQIEYVHYPGV-PITNFSQMDVVGQTVCYVHKSKVTVSSDRFR 1481
Query: 1447 MANASEMDRQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEALRSTDGDSGS 1506
++ + R H V F +T+ V+ P++T N GL++ +GA + + L+ TD D+ +
Sbjct: 1482 FIISNGL-RTEHGV-FEITLETVDRALPVVTRNKGLRLAQGAVGLLSPDLLQLTDPDTPA 1539
Query: 1507 EDLVYTIEQ-PSNGRVVLRGAPGTEVRSFTQAQLDGGLVLFSHRG--TLDGGFRFRLSDG 1563
E+L + + Q P +G++ L G G +FTQ +D V + H G + F F +DG
Sbjct: 1540 ENLTFLLVQLPQHGQLYLWGT-GLLQHNFTQQDVDSKNVAYRHSGGDSQTDCFTFMATDG 1598
Query: 1564 EHTSPGHFFRVTA-QKQVLLSLKGSQ--------TLTVCPGSVQPL---------SSQTL 1605
T+ G ++ VL +++ Q TL P V L +S+ L
Sbjct: 1599 --TNQGFIVNGRVWEEPVLFTIQVDQLDKTAPRITLLHSPSQVGLLKNGCYGIYITSRVL 1656
Query: 1606 RASSSAGTDPQLLLYRVVRGPQLGRLFHAQQDSTGEAL-VNFTQAEVYAGNILYEHEMPP 1664
+AS D Q +++++++GP+ G H + +TGE + F+Q ++ + ILY
Sbjct: 1657 KASDPDTEDDQ-IIFKILQGPKHG---HLENTTTGEFIHEKFSQKDLNSKTILY----II 1708
Query: 1665 EPFWEAH-DTLELQLSSP 1681
P E + DT+E Q+ P
Sbjct: 1709 NPSLEVNSDTVEFQIMDP 1726
Score = 134 bits (338), Expect = 8e-31
Identities = 312/1307 (23%), Positives = 488/1307 (37%), Gaps = 227/1307 (17%)
Query: 832 GNLQLQGTRLSDGQGF--TQDDIQAGRVTYGATARASEAVEDTFRFRVTAPPYFSPLYTF 889
G LQ L G+GF T D+QAG V Y S++ +D FR+ + S + F
Sbjct: 454 GGLQHGWLTLRGGKGFLFTVADLQAGVVRYHHDD--SDSTKDFVVFRIF-DGHHSIRHKF 510
Query: 890 PIHIGGDPDAP--VLTNVLLVVPEGGEGVLSADHLFVKSLNSAS-YLY----------EV 936
PI++ D+P ++TNV++ + EG ++ L ++++ Y++ E+
Sbjct: 511 PINVLPKDDSPPFLITNVVIELEEGQTILIQGSMLRASDVDASDDYIFFNITKPPQAGEI 570
Query: 937 MERPRHGRLAWRGTQDKTTMVTSFTNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSG 996
M++P G + + V F DL G + Y+H E ED FV E
Sbjct: 571 MKKPGPGLIGYP--------VHGFLQRDLFNGIIYYRHFGGEIFEDSFQFVLWDSHEPPN 622
Query: 997 DMAWEEVRGVFRVAIQPVNDHAPVQT--ISRIFHVARGGRRLLTTDDVAFSDADSGFADA 1054
V V + I PV+D P + +SR V +T + F D++S D
Sbjct: 623 ----LSVPQVATIHITPVDDQLPKEAPGVSRHLVVKETEVAYITKKQLHFIDSES--YDR 676
Query: 1055 QLVLT----------RKDLLFGSIVAVDE-------PTRPIYR-FTQEDLRKRRVLFVHS 1096
+LV T + L G + VD PT R FTQ + +V ++
Sbjct: 677 ELVYTITTPPFFSFSHRHLDAGKLFMVDSIPKVVKNPTALELRSFTQHAVNYMKVAYMPP 736
Query: 1097 GADRGW----IQLQVS-DGQHQAT--------ALLEVQASEPYLRVANGSSLVVPQGGQG 1143
D G +Q S QH T +L V P A + L V +GGQ
Sbjct: 737 MQDIGPHCRDVQFTFSVSNQHGGTLHGICFNITILPVDNQVPE---AFTNPLKVTEGGQS 793
Query: 1144 TIDTA---VLHLDTNLDIRSGDEVHYHVTAGPRWGQLVRAGQPATA---FSQQDLLDGAV 1197
I T + DT LD + + P G++ G P + FS DL V
Sbjct: 794 IISTEHILISDADTKLD-----NIDLSLRELPLHGRVELNGFPLNSGGTFSWGDLHTLKV 848
Query: 1198 LYSHNGSLSPRDTMAFSVEAGPVHTDATLQVTIALEGPLAP-LKLVRHKKIYVFQGEAAE 1256
Y H+G+ +D + V G + L V + P LK + +G
Sbjct: 849 RYQHDGTEVLQDDLLLEVTDGTNSAEFVLHVEVFPVNDEPPVLKADLMPVMNCSEGGEVV 908
Query: 1257 IRRDQLEAAQEAVPPADIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTG 1316
I + + A ++F + P G +V R + V FSQ V +
Sbjct: 909 ITSEYIFATDVDSDNLKLMFVIAREPQHG---VVRRAGVT--------VDQFSQRDVISE 957
Query: 1317 RVLYLHSRPEAWS----DAFSLDVASGLGAP---------------LEGVLVELEVLPAA 1357
V Y H+ E D +L V+ G P L ++
Sbjct: 958 AVTYKHTGGEIGLMPCFDTITLVVSDGEAGPFVNGCCYNGPNPSVPLHASFPVYDLNITV 1017
Query: 1358 IPLEAQN--------FSVPEGGSLTLAPPLLRVSGPYFPTLLGLSLQVLEPPQHGALQK- 1408
P++ Q F V EG S L L + P L ++ PPQ G L+
Sbjct: 1018 YPVDNQPPSIAIGPVFVVDEGCSTALTVNHLSATDPD-TAADDLEFVLVSPPQFGYLENI 1076
Query: 1409 ------EDGPQARTLSAFSWRMVEEQLIRYV---HDGSETLTDSFVLMANASEMDRQSHP 1459
E ++ +F W+ + I YV H E D F + + S
Sbjct: 1077 LPSVGFEKSNIGISIDSFQWKDMNAFHINYVQSRHLRIEPTADQFTVYVTDGK--HHSLE 1134
Query: 1460 VAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEALRSTDGDSGSEDLVYTIEQ-PSN 1518
+ F++ + P ND+ P + + EG + + + + D D + L+++I Q P +
Sbjct: 1135 IPFSIIINPTNDEAPDFVVQN-ITVCEGQMKELDSSIISAVDLDIPQDALLFSITQKPRH 1193
Query: 1519 GRVVLRG---------------APGTEVRSFTQAQLDGGLVL-FSHRGT--LDGGFRFRL 1560
G ++ RG V SF+ L G+ L + H + L F +L
Sbjct: 1194 GLLIDRGFSKDFSENKQPANPHQKHAPVHSFSMELLKTGMRLTYMHDDSESLADDFTIQL 1253
Query: 1561 SDGEH----TSPGHFFRVTAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASSSAGTDPQ 1616
SDG+H T V +K +LS K + + G + +SS L A P+
Sbjct: 1254 SDGKHKILKTISVEVIPVNDEKP-MLSKKAEIAMNM--GETRIISSAILSAIDE--DSPR 1308
Query: 1617 LLLYRVV-RGPQLGRLFHAQQDSTGEALVNF------TQAEVYAGNILYEHEMPPEPFWE 1669
+Y V R PQ G+L Q G V TQ EV + Y H + +
Sbjct: 1309 EKIYYVFERLPQNGQL----QLKIGRDWVPLSPGMKCTQEEVDLNLLRYTHTGAMDS--Q 1362
Query: 1670 AHDTLELQL----SSPPARDVAATLAVAVSFEAACPQRPSHLWKNKGLWVPEGQRARITV 1725
D+ L + PA D T+ + +P L V +G R +T
Sbjct: 1363 NQDSFTFYLWDGNNRSPALDCQITIKDMEKGDIVILTKP--------LVVSKGDRGFLTT 1414
Query: 1726 AALDASNLLASVPSPQRSEHDVLFQVTQFPSRGQLLVSEEPLHAGQP--HFLQSQLAAGQ 1783
L A V + E ++L+ +T P GQ+ P G P +F Q +
Sbjct: 1415 TTLLA------VDGTDKPE-ELLYVITSPPRYGQIEYVHYP---GVPITNFSQMDVVGQT 1464
Query: 1784 LVYAHGGGGT-QQDGFHFRAHLQGPAGASVAGPQTSEA-FAITVRDVNERPPQPQASVPL 1841
+ Y H T D F F G +T F IT+ V+ P + L
Sbjct: 1465 VCYVHKSKVTVSSDRFRFIIS---------NGLRTEHGVFEITLETVDRALPVVTRNKGL 1515
Query: 1842 RLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQADVDS 1901
RL +G+ +S L + DPD+ + + + + P +G L L G GL FTQ DVDS
Sbjct: 1516 RLAQGAVGLLSPDLLQLTDPDTPAENLTFLLVQLPQHGQLYLWGTGLLQ-HNFTQQDVDS 1574
Query: 1902 GRLAFV-ANGSSVAGIFQLSMSDGASPPLPMSLAVDILPSAIEVQL-----RAP----LE 1951
+A+ + G S F +DG + ++ V P +Q+ AP L
Sbjct: 1575 KNVAYRHSGGDSQTDCFTFMATDGTNQGFIVNGRVWEEPVLFTIQVDQLDKTAPRITLLH 1634
Query: 1952 VPQALGRSSLSQQQLRVVS--------DREEPEAAYRLIQGPQYGHL 1990
P +G + + S D E+ + ++++QGP++GHL
Sbjct: 1635 SPSQVGLLKNGCYGIYITSRVLKASDPDTEDDQIIFKILQGPKHGHL 1681
Score = 97.8 bits (242), Expect = 1e-19
Identities = 326/1497 (21%), Positives = 534/1497 (35%), Gaps = 226/1497 (15%)
Query: 801 TLTTAHLEATLEEAGPSPPTFHYEVVQAPRKGNLQLQGTRLSDGQGFTQDDIQAGRVTYG 860
+LTT+ L+ EE P + + +AP +G + FT D+ ++ Y
Sbjct: 314 SLTTSVLDC--EEDETPKPLLVFNITKAPLQGYVTHLLDHTRPISSFTWKDLSDMQIAYQ 371
Query: 861 A-TARASEAVEDTFRFRVTAPPYFSPLYTFPIHIG---GDPDAP-VLTNVLLVVPEGGEG 915
+ SE D V +F +HI D +AP V N L + EG
Sbjct: 372 PPNSSHSERRHDEVELEVY-DFFFERSAPMTVHISIRTADTNAPRVSWNTGLSLLEGQSR 430
Query: 916 VLSADHLFVKSLNSASYLYEV-MERPRHGRLAWRGTQDKTTMVTSFTNEDLLRGRLVYQH 974
++ + V + + V + +HG L RG + FT DL G + Y H
Sbjct: 431 AITWEQFQVVDNDDIGAVRLVTVGGLQHGWLTLRGGKGFL-----FTVADLQAGVVRYHH 485
Query: 975 DDSETTEDDIPFVATRQGESSGDMAWEEVRGVFRVAIQPVNDHAPVQTISRIFHVARGGR 1034
DDS++T+D FV R + +R F + + P +D P + + + G
Sbjct: 486 DDSDSTKD---FVVFRIFDGH-----HSIRHKFPINVLPKDDSPPFLITNVVIELEEGQT 537
Query: 1035 RLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIVAVDEP---TRPIYRFTQEDLRKRRV 1091
L+ + SD D+ D K G I+ P P++ F Q DL +
Sbjct: 538 ILIQGSMLRASDVDAS-DDYIFFNITKPPQAGEIMKKPGPGLIGYPVHGFLQRDLFNGII 596
Query: 1092 LFVHSGAD--RGWIQLQVSDGQH-------QATALLEVQASEPYLRVANGSS--LVVPQG 1140
+ H G + Q + D Q + + + A G S LVV +
Sbjct: 597 YYRHFGGEIFEDSFQFVLWDSHEPPNLSVPQVATIHITPVDDQLPKEAPGVSRHLVVKET 656
Query: 1141 GQGTIDTAVLHLDTNLDIRSGDE--------------VHYHVTAGPRW--GQLVRAGQPA 1184
I LH +D S D H H+ AG + + + +
Sbjct: 657 EVAYITKKQLHF---IDSESYDRELVYTITTPPFFSFSHRHLDAGKLFMVDSIPKVVKNP 713
Query: 1185 TAFSQQDLLDGAVLYSHNGSLSP--------RD---TMAFSVEAGPVHTDATLQVTIALE 1233
TA + AV Y + P RD T + S + G +TI
Sbjct: 714 TALELRSFTQHAVNYMKVAYMPPMQDIGPHCRDVQFTFSVSNQHGGTLHGICFNITILPV 773
Query: 1234 GPLAPLKLVRHKKIYVFQGEAAEIRRDQLEAAQEAVPPADIVFSVKSPPSAGYLVMVSRG 1293
P K V +G + I + + + +I S++ P G R
Sbjct: 774 DNQVPEAFTNPLK--VTEGGQSIISTEHILISDADTKLDNIDLSLRELPLHG------RV 825
Query: 1294 ALADEPPSLDPVQSFSQEAVDTGRVLYLHSRPEAWSDAFSLDVASGLGAPLEGVLVELEV 1353
L P L+ +FS + T +V Y H E D L+V G + ++ +EV
Sbjct: 826 ELNGFP--LNSGGTFSWGDLHTLKVRYQHDGTEVLQDDLLLEVTDGTNS--AEFVLHVEV 881
Query: 1354 LPA--------AIPLEAQNFSVPEGGSLTLAPPLLRVSGPYFPTLLGLSLQVLEPPQHGA 1405
P A + N S EGG + + + + L L + PQHG
Sbjct: 882 FPVNDEPPVLKADLMPVMNCS--EGGEVVITSEYIFATDVDSDN-LKLMFVIAREPQHGV 938
Query: 1406 LQKEDGPQARTLSAFSWRMVEEQLIRYVHDGSE----TLTDSFVLMANASEMD------- 1454
+++ T+ FS R V + + Y H G E D+ L+ + E
Sbjct: 939 VRR----AGVTVDQFSQRDVISEAVTYKHTGGEIGLMPCFDTITLVVSDGEAGPFVNGCC 994
Query: 1455 ----------RQSHPV-AFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEALRSTDGD 1503
S PV +TV PV++QPP + + EG + + L +TD D
Sbjct: 995 YNGPNPSVPLHASFPVYDLNITVYPVDNQPPSIAIGPVFVVDEGCSTALTVNHLSATDPD 1054
Query: 1504 SGSEDLVYTIEQPSNGRVVLRGAP---------GTEVRSFTQAQLDGGLVLFSHRGTL-- 1552
+ ++DL + + P + P G + SF ++ + + L
Sbjct: 1055 TAADDLEFVLVSPPQFGYLENILPSVGFEKSNIGISIDSFQWKDMNAFHINYVQSRHLRI 1114
Query: 1553 ---DGGFRFRLSDGEHTSPGHFFRV-------TAQKQVLLSLKGSQTLTVCPGSVQPLSS 1602
F ++DG+H S F + A V+ Q +TVC G ++ L S
Sbjct: 1115 EPTADQFTVYVTDGKHHSLEIPFSIIINPTNDEAPDFVV------QNITVCEGQMKELDS 1168
Query: 1603 QTLRASSSAGTDPQLLLYRVVRGPQLGRLF---HAQQDSTGEALVNFTQAEVYAGNILYE 1659
+ A LL+ + + P+ G L ++ S + N Q + E
Sbjct: 1169 SIISA-VDLDIPQDALLFSITQKPRHGLLIDRGFSKDFSENKQPANPHQKHAPVHSFSME 1227
Query: 1660 HEMPPEPFWEAHDTLE-------LQLSSPPARDVAATLAVAVSFEAACPQRPSHLWKNKG 1712
HD E +QLS + + T++V V ++P L K
Sbjct: 1228 LLKTGMRLTYMHDDSESLADDFTIQLSDGKHK-ILKTISVEVI--PVNDEKPM-LSKKAE 1283
Query: 1713 LWVPEGQRARITVAALDASNLLASVPSPQRSEHDVLFQVTQFPSRGQLLV----SEEPLH 1768
+ + G+ I+ A L A SP+ + + + P GQL + PL
Sbjct: 1284 IAMNMGETRIISSAILSA----IDEDSPREK---IYYVFERLPQNGQLQLKIGRDWVPLS 1336
Query: 1769 AGQPHFLQSQLAAGQLVYAHGGGGTQQDGFHFRAHLQGPAGASVAGPQTSEAF--AITVR 1826
G Q ++ L Y H G Q+ F +L G S A IT++
Sbjct: 1337 PGM-KCTQEEVDLNLLRYTHTGAMDSQNQDSFTFYLWD-------GNNRSPALDCQITIK 1388
Query: 1827 DVNERPPQPQASVPLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGG 1886
D+ E+ + PL +++G R ++ L VD P E+ Y + P G + V
Sbjct: 1389 DM-EKGDIVILTKPLVVSKGDRGFLTTTTLLAVDGTDKPEELLYVITSPPRYGQIEYVHY 1447
Query: 1887 GLGPVTRFTQADVDSGRLAFVANGSSVAGI--FQLSMSDGASPPLPM-SLAVDILPSAIE 1943
P+T F+Q DV + +V F+ +S+G + + ++ + A+
Sbjct: 1448 PGVPITNFSQMDVVGQTVCYVHKSKVTVSSDRFRFIISNGLRTEHGVFEITLETVDRALP 1507
Query: 1944 VQLRAPLEVPQALGRSSLSQQQLRVVSDREEP--EAAYRLIQGPQYGHLLVGGRP--TSA 1999
V R + A G L L ++D + P + L+Q PQ+G L + G
Sbjct: 1508 VVTRNK-GLRLAQGAVGLLSPDLLQLTDPDTPAENLTFLLVQLPQHGQLYLWGTGLLQHN 1566
Query: 2000 FSQFQIDQGEVVFAFTNFSSSHDHFRVLALARGVNASAVVNVTV---------------- 2043
F+Q +D V + + S D F +A G N +VN V
Sbjct: 1567 FTQQDVDSKNVAYRHSGGDSQTDCFTFMA-TDGTNQGFIVNGRVWEEPVLFTIQVDQLDK 1625
Query: 2044 ----RALLHVWAG-GPWPQGA-TLRLDPTVLDAGELANRTGSVPRFRLLEGPRHGRVVRV 2097
LLH + G G + + VL A + + F++L+GP+HG +
Sbjct: 1626 TAPRITLLHSPSQVGLLKNGCYGIYITSRVLKASDPDTEDDQI-IFKILQGPKHGHL--- 1681
Query: 2098 PRARTEPGGSQLVEQFTQQDLEDGRL------GLEVGRP--EGRAPGPAGDSLTLEL 2146
G + E+F+Q+DL + LEV E + P G+S T ++
Sbjct: 1682 ---ENTTTGEFIHEKFSQKDLNSKTILYIINPSLEVNSDTVEFQIMDPTGNSATPQI 1735
Score = 89.0 bits (219), Expect = 5e-17
Identities = 194/867 (22%), Positives = 333/867 (38%), Gaps = 111/867 (12%)
Query: 440 AEGGTAWLEWRHVQPTLDLMEAELRKSQVLFSVTRGARHGELELDIPGAQARKMFTLLDV 499
+EGG + ++ T + + +++F + R +HG + F+ DV
Sbjct: 902 SEGGEVVITSEYIFAT----DVDSDNLKLMFVIAREPQHGVVRR---AGVTVDQFSQRDV 954
Query: 500 VNRKARFIHDGSE----DTSDQLVLEVSVTARVPMPS-CLRRGQT-----------YLLP 543
++ + H G E D + L VS P + C G Y L
Sbjct: 955 ISEAVTYKHTGGEIGLMPCFDTITLVVSDGEAGPFVNGCCYNGPNPSVPLHASFPVYDLN 1014
Query: 544 IQVNPV-NDPPHIIFPHGSLMVILEHTQKPLGPEVFQAYDPDSACEGLTFQVLGTSSGLP 602
I V PV N PP I G + V+ E L A DPD+A + L F ++
Sbjct: 1015 ITVYPVDNQPPSIAI--GPVFVVDEGCSTALTVNHLSATDPDTAADDLEFVLVSPPQFGY 1072
Query: 603 VER--------RDQPGEPATEFSCRELEAGSLVYVH----RGGPAQD-LTFRVSDGLQAS 649
+E + G F +++ A + YV R P D T V+DG S
Sbjct: 1073 LENILPSVGFEKSNIGISIDSFQWKDMNAFHINYVQSRHLRIEPTADQFTVYVTDGKHHS 1132
Query: 650 PPATLKVVAIRPAIQIHRS---TGLRLAQGSAMPILPANLSVETNAVGQDVSVLFRVTGA 706
++ I P + + +G + + +S + QD ++LF +T
Sbjct: 1133 LEIPFSII-INPTNDEAPDFVVQNITVCEGQMKELDSSIISAVDLDIPQD-ALLFSITQK 1190
Query: 707 LQFGELQKQGAGGVEGAEWWATQAFHQRD--VEQGRVRYLSTDPQ-HHAYDTVENLA--- 760
+ G L +G + +E HQ+ V + L T + + +D E+LA
Sbjct: 1191 PRHGLLIDRGFSK-DFSENKQPANPHQKHAPVHSFSMELLKTGMRLTYMHDDSESLADDF 1249
Query: 761 -LEVQVGQ-EILSNLSFPVTIQRATVWMLRLEPLHTQNTQQETLTTAHLEATLEEAGPSP 818
+++ G+ +IL +S V ML + N + + ++ + + ++E P
Sbjct: 1250 TIQLSDGKHKILKTISVEVIPVNDEKPMLSKKAEIAMNMGETRIISSAILSAIDEDSPRE 1309
Query: 819 PTFHYEVVQAPRKGNLQLQGTR----LSDGQGFTQDDIQAGRVTYGATARASEAVEDTFR 874
+ Y + P+ G LQL+ R LS G TQ+++ + Y T +D+F
Sbjct: 1310 KIY-YVFERLPQNGQLQLKIGRDWVPLSPGMKCTQEEVDLNLLRYTHTGAMDSQNQDSFT 1368
Query: 875 FRVTAPPYFSPLYTFPIHIGG--DPDAPVLTNVLLVVPEGGEGVLSADHLFVKSLNSA-- 930
F + SP I I D +LT L VV +G G L+ L
Sbjct: 1369 FYLWDGNNRSPALDCQITIKDMEKGDIVILTKPL-VVSKGDRGFLTTTTLLAVDGTDKPE 1427
Query: 931 SYLYEVMERPRHGRLAWRGTQDKTTMVTSFTNEDLLRGRLVYQHDDSETTEDD-IPFVAT 989
LY + PR+G++ + +T+F+ D++ + Y H T D F+ +
Sbjct: 1428 ELLYVITSPPRYGQIEY--VHYPGVPITNFSQMDVVGQTVCYVHKSKVTVSSDRFRFIIS 1485
Query: 990 RQGESSGDMAWEEVRGVFRVAIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDADS 1049
+ GVF + ++ V+ PV T ++ +A+G LL+ D + +D D+
Sbjct: 1486 NGLRTE--------HGVFEITLETVDRALPVVTRNKGLRLAQGAVGLLSPDLLQLTDPDT 1537
Query: 1050 -----GFADAQLVLTRKDLLFGSIVAVDEPTRPIYRFTQEDLRKRRVLFVHSGAD--RGW 1102
F QL + L+G+ + + FTQ+D+ + V + HSG D
Sbjct: 1538 PAENLTFLLVQLPQHGQLYLWGTGLLQ-------HNFTQQDVDSKNVAYRHSGGDSQTDC 1590
Query: 1103 IQLQVSDGQHQA----------TALLEVQASE-----PYLRVANGSSLV--VPQGGQGTI 1145
+DG +Q L +Q + P + + + S V + G G
Sbjct: 1591 FTFMATDGTNQGFIVNGRVWEEPVLFTIQVDQLDKTAPRITLLHSPSQVGLLKNGCYGIY 1650
Query: 1146 DTAVLHLDTNLDIRSGDEVHYHVTAGPRWGQLVRAGQPA---TAFSQQDLLDGAVLYSHN 1202
T+ + ++ D D++ + + GP+ G L FSQ+DL +LY N
Sbjct: 1651 ITSRVLKASDPDTED-DQIIFKILQGPKHGHLENTTTGEFIHEKFSQKDLNSKTILYIIN 1709
Query: 1203 GSLSPR-DTMAFSVEAGPVHTDATLQV 1228
SL DT+ F + P AT Q+
Sbjct: 1710 PSLEVNSDTVEFQI-MDPTGNSATPQI 1735
Score = 79.7 bits (195), Expect = 3e-14
Identities = 213/1014 (21%), Positives = 384/1014 (37%), Gaps = 153/1014 (15%)
Query: 435 SPLVVAEGGTAWLEWRHVQPTLDLMEAELRKSQVLFSVTRGARHGELELDIPGAQARKMF 494
+PL V EGG + + H+ + +A+ + + S+ HG +EL+ + F
Sbjct: 783 NPLKVTEGGQSIISTEHIL----ISDADTKLDNIDLSLRELPLHGRVELNGFPLNSGGTF 838
Query: 495 TLLDVVNRKARFIHDGSEDTSDQLVLEVSVTARVPMPSCLRRGQTYLLPIQVNPVNDPPH 554
+ D+ K R+ HDG+E D L+LEV+ ++L ++V PVND P
Sbjct: 839 SWGDLHTLKVRYQHDGTEVLQDDLLLEVTDGT---------NSAEFVLHVEVFPVNDEPP 889
Query: 555 IIFPHGSLMVIL---EHTQKPLGPEVFQAYDPDSACEGLTFQVLGTSSGLPVERRDQPGE 611
++ LM ++ E + + E A D DS L F V+ V RR G
Sbjct: 890 VL--KADLMPVMNCSEGGEVVITSEYIFATDVDSDNLKLMF-VIAREPQHGVVRR--AGV 944
Query: 612 PATEFSCRELEAGSLVYVHRGG-----PAQD-LTFRVSDG-------------------L 646
+FS R++ + ++ Y H GG P D +T VSDG L
Sbjct: 945 TVDQFSQRDVISEAVTYKHTGGEIGLMPCFDTITLVVSDGEAGPFVNGCCYNGPNPSVPL 1004
Query: 647 QASPPATLKVVAIRPAIQIHRSTGLR----LAQGSAMPILPANLSVETNAVGQDVSVLFR 702
AS P + + P S + + +G + + +LS D + F
Sbjct: 1005 HASFPVYDLNITVYPVDNQPPSIAIGPVFVVDEGCSTALTVNHLSATDPDTAAD-DLEFV 1063
Query: 703 VTGALQFGEL---------QKQGAG-GVEGAEWWATQAFHQRDVEQGRVRYLSTDPQHHA 752
+ QFG L +K G ++ +W AFH V+ +R T Q
Sbjct: 1064 LVSPPQFGYLENILPSVGFEKSNIGISIDSFQWKDMNAFHINYVQSRHLRIEPTADQFTV 1123
Query: 753 YDTVENLALEVQVGQEILSNLSFPVTIQRATVWMLRLEPLHTQNTQQETLTTAHLEATLE 812
Y T + +++ I+ N P + + + Q + ++ + ++ +
Sbjct: 1124 YVT-DGKHHSLEIPFSIIIN---PTNDEAPDFVVQNITVCEGQMKELDSSIISAVDLDIP 1179
Query: 813 EAGPSPPTFHYEVVQAPRKGNLQLQG---------------TRLSDGQGFTQDDIQAG-R 856
+ + + Q PR G L +G + + F+ + ++ G R
Sbjct: 1180 Q-----DALLFSITQKPRHGLLIDRGFSKDFSENKQPANPHQKHAPVHSFSMELLKTGMR 1234
Query: 857 VTYGATARASEAVEDTFRFRVTAPPYFSPLYTFPIH-IGGDPDAPVLTNVLLVVPEGGEG 915
+TY SE++ D F +++ + L T + I + + P+L+ + GE
Sbjct: 1235 LTY--MHDDSESLADDFTIQLSDGKH-KILKTISVEVIPVNDEKPMLSKKAEIAMNMGET 1291
Query: 916 --VLSADHLFVKSLNSASYLYEVMER-PRHGRLAWRGTQDKTTMVTSF--TNEDLLRGRL 970
+ SA + + +Y V ER P++G+L + +D + T E++ L
Sbjct: 1292 RIISSAILSAIDEDSPREKIYYVFERLPQNGQLQLKIGRDWVPLSPGMKCTQEEVDLNLL 1351
Query: 971 VYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGVFRVAIQPVNDHAPVQTISRIFHVA 1030
Y H + +++ F ++ A + ++ I+ + + + +++ V+
Sbjct: 1352 RYTHTGAMDSQNQDSFTFYLWDGNNRSPALD-----CQITIKDM-EKGDIVILTKPLVVS 1405
Query: 1031 RGGRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIVAVDEPTRPIYRFTQEDLRKRR 1090
+G R LTT + D + V+T +G I V P PI F+Q D+ +
Sbjct: 1406 KGDRGFLTTTTLLAVDGTDKPEELLYVITSPP-RYGQIEYVHYPGVPITNFSQMDVVGQT 1464
Query: 1091 VLFVHS-----GADRGWIQLQVSDGQHQATALLEV---QASEPYLRVANGSSLVVPQGGQ 1142
V +VH +DR + +S+G + E+ V L + QG
Sbjct: 1465 VCYVHKSKVTVSSDR--FRFIISNGLRTEHGVFEITLETVDRALPVVTRNKGLRLAQGAV 1522
Query: 1143 GTIDTAVLHLDTNLDIRSGDEVHYHVTAGPRWGQLVRAGQPATA--FSQQDLLDGAVLYS 1200
G + +L L T+ D + + + + P+ GQL G F+QQD+ V Y
Sbjct: 1523 GLLSPDLLQL-TDPD-TPAENLTFLLVQLPQHGQLYLWGTGLLQHNFTQQDVDSKNVAYR 1580
Query: 1201 HNGSLSPRDTMAFSVEAG--------------PV-------HTDATLQVTIALEGPLAPL 1239
H+G S D F G PV D T L P + +
Sbjct: 1581 HSGGDSQTDCFTFMATDGTNQGFIVNGRVWEEPVLFTIQVDQLDKTAPRITLLHSP-SQV 1639
Query: 1240 KLVRHKKIYVFQGEAAEIRRDQLEAAQEAVPPADIVFSVKSPPSAGYLVMVSRGALADEP 1299
L+++ ++ I L+A+ I+F + P G+L + G E
Sbjct: 1640 GLLKNGCYGIY------ITSRVLKASDPDTEDDQIIFKILQGPKHGHLENTTTGEFIHE- 1692
Query: 1300 PSLDPVQSFSQEAVDTGRVLY-LHSRPEAWSDAFSLDVASGLGAPLEGVLVELE 1352
FSQ+ +++ +LY ++ E SD + G ++EL+
Sbjct: 1693 -------KFSQKDLNSKTILYIINPSLEVNSDTVEFQIMDPTGNSATPQILELK 1739
>gi|108773804 Fraser syndrome 1 [Homo sapiens]
Length = 4011
Score = 172 bits (437), Expect = 3e-42
Identities = 295/1326 (22%), Positives = 523/1326 (39%), Gaps = 161/1326 (12%)
Query: 823 YEVVQAPRKGNLQL----QGTRLSDGQGFTQDDIQAGRVTYGATARASEAVEDTFRF-RV 877
+ VV P G L L + +L F+ D+ +V + + E + + F ++
Sbjct: 1139 FHVVSTPTNGQLVLSRNGKEVQLDKAGRFSWKDVNEKKVRF---VHSKEKLRKGYLFLKI 1195
Query: 878 TAPPYFSPLYTFPIHIGGDPDAPVLTNVLLVVPEGGEGVLSADHLFVKSL-NSASYLYEV 936
+ +FS I VL N +L + G ++ L ++ N + E+
Sbjct: 1196 SDQQFFSEPQLINIQAFSTQAPYVLRNEVLHISRGERATITTQMLDIRDDDNPQDVVIEI 1255
Query: 937 MERPRHGRLAWRGTQDKTTMVTSFTNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSG 996
++ P HG+L + Q T + F ++L RG L Y HD S++T D + + G S
Sbjct: 1256 IDPPLHGQLL-QTLQSPATPIYQFQLDELSRGLLHYAHDGSDSTSD-VAVLQANDGHSFH 1313
Query: 997 DMAWEEVRGVFRVAIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQL 1056
++ +F+V P ND + + V GG L T+ + ++A A+ +
Sbjct: 1314 NI-------LFQVKTVPQNDRGLQLVANSMVWVPEGGM-LQITNRILQAEAPGASAEEII 1365
Query: 1057 VLTRKDL-LFGSIVAV-----DEPT------------RPIYRFTQEDLRKRRVLFVHSGA 1098
+D FG +V + D P P FTQ+D+ + V + HSGA
Sbjct: 1366 YKITQDYPQFGEVVLLVNMPADSPADEGQHLPDGRTATPTSTFTQQDINEGIVWYRHSGA 1425
Query: 1099 --DRGWIQLQVSDGQHQAT---------ALLEVQASEPYLRVANGSSLVVPQGGQGTIDT 1147
+ +VS + T A+L P + + + + G I
Sbjct: 1426 PAQSDSFRFEVSSASNAQTRLESHMFNIAILPQTPEAPKVSLEASLHMTAREDGLTVIQP 1485
Query: 1148 AVLHLDTNLDIRSGDEVHYHVTAG--PRWGQLVRAGQPATA---FSQQDLLDGAVLYSHN 1202
L N + SG ++ Y++T P G + P + F+Q+D+ G V+Y
Sbjct: 1486 HSLSF-INSEKPSG-KIVYNITLPLHPNQGIIEHRDHPHSPIRYFTQEDINQGKVMYRPP 1543
Query: 1203 GSLSP-RDTMAFSVEAGPV------------HTDATLQVTIAL--EGPLAPLKLVRHKKI 1247
+ ++ MAFS P HT + +TI L P+ V ++
Sbjct: 1544 PAAPHLQELMAFSFAGLPESVKFHFTVSDGEHTSPEMVLTIHLLPSDQQLPVFQVTAPRL 1603
Query: 1248 YVFQGEAAEIRRDQLEAAQEAVPPADIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQS 1307
V G + + Q+ P ++ F ++ PP G L+ + A+ + +
Sbjct: 1604 AVSPGGSTSVGL-QVVVRDAETAPKELFFELRRPPQHGVLLKHT----AEFRRPMATGDT 1658
Query: 1308 FSQEAVDTGRVLYLHSRPEAWSDAFSLDVASGLGAPLEGVLVELEVLPAAIPLEAQNFSV 1367
F+ E V+ + Y+H D+ + V GL + V VE+ + P A S+
Sbjct: 1659 FTYEDVEKNALQYIHDGSSTREDSMEISVTDGLTVTMLEVRVEVSLSEDRGPRLAAGSSL 1718
Query: 1368 P-----EGGSLTLAPPLLRVSGPYFPTLLGLSLQVLEPPQHGALQKEDGPQARTLSA--- 1419
+ ++ L V + + L L P +G L + G + LS
Sbjct: 1719 SITVASKSTAIITRSHLAYVDDSSPDPEIWIQLNYL--PSYGTLLRISGSEVEELSEVSN 1776
Query: 1420 FSWRMVEEQLIRY---VHDGSETLTDSFVLMANASEMDRQSHPVAFTVTVLPVNDQPPIL 1476
F+ + + IRY +TDSF + + + + + FT+ + P + PP++
Sbjct: 1777 FTMEDINNKKIRYSAVFETDGHLVTDSFYFSVSDMDHNHLDNQI-FTIMITPAENPPPVI 1835
Query: 1477 TTNTGLQMWEGATAPIPAEALRSTDGDSGSE-DLVYTIEQ-PSNGRVVLRGAP---GTEV 1531
+ + EG AP+ +TD D + D + + P G + G G E
Sbjct: 1836 AFADLITVDEGGRAPLSFHHFFATDDDDNLQRDAIIKLSALPKYGCIENTGTGDRFGPET 1895
Query: 1532 RSFTQAQ------LDGGLVLF-----SHRGTLDGGFRFRLSDGEHTSPGHFFRVTAQKQV 1580
S +A L+ + F S T D F F +SDG S H +T +++
Sbjct: 1896 ASDLEASFPIQDVLENYIYYFQSVHESIEPTHDI-FSFYVSDGTSRSEIHSINITIERKN 1954
Query: 1581 LLSLKGSQTLTVCPGSVQPLSSQTLRASSSAG-----TDPQLLLYRVVRGPQLGRLFHAQ 1635
+T+ P VQ LSS + ++SS T L++ + + P G + Q
Sbjct: 1955 ----DEPPRMTLQPLRVQ-LSSGVVISNSSLSLQDLDTPDNELIFVLTKKPDHGHVLWRQ 2009
Query: 1636 QDS----TGEALVN---FTQAEVYAGNILYEHEMPPEPFWEAHDTLELQLSSPPARDVAA 1688
S G LV FT ++ AG + Y +P E +L L R
Sbjct: 2010 TASEPLENGRVLVQGSTFTYQDILAGLVGYVPSVPGMVVDEFQFSLTDGLHVDTGR---- 2065
Query: 1689 TLAVAVSFEAACPQRPSHLWKNKGLWVPEGQRARITVAALDASNLLASVPSPQRSEHDVL 1748
+ + E P HL N+GL + G ARIT L +++ +H V+
Sbjct: 2066 ---MKIYTELPASDTP-HLAINQGLQLSAGSVARITEQHLKVTDI-------DSDDHQVM 2114
Query: 1749 FQVTQFPSRGQLLVSE----EPLHAGQP--HFLQSQLAAGQLVYAHGGGGTQQDGFHFRA 1802
+ + + P G+L + + E + P F Q+ ++ GQ Y+HG G F F+
Sbjct: 2115 YIMKEDPGAGRLQMMKHGNLEQISIKGPIRSFTQADISQGQPEYSHGTG-EPGGSFAFKF 2173
Query: 1803 HLQGPAGASVAGPQTSEAFAITVRDVNERPPQPQASVPLRLTRGSRAPISRAQLSVVDPD 1862
+ G + ++F+I++ + ++ PP + L L S I+ QLS D D
Sbjct: 2174 DVVDGEGNRLI----DKSFSISILE-DKSPPVITTNKGLVLDENSVKKITTLQLSATDQD 2228
Query: 1863 SAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQADVDSGRLAFV--ANGSSVAGIFQLS 1920
S P E+ Y + R P G L ++ FTQAD+ S + +V + + F +
Sbjct: 2229 SGPTELIYRITRQPQLGHLEHAASPGIQISSFTQADLTSRNVQYVHSSEAEKHSDAFSFT 2288
Query: 1921 MSDGASP-PLPMSLAVDILPSAIEVQLRAPLEVPQALGRSSLSQQQLRVV-SDREEPEAA 1978
+SDG S + + + ++ V + V + + R ++++ +L+ V +D E
Sbjct: 2289 LSDGVSEVTQTFHITLHPVDDSLPVVQNLGMRVQEGM-RKTITEFELKAVDADTEAESVT 2347
Query: 1979 YRLIQGPQYGHL--LVGGRP---TSAFSQFQIDQGEVVFAFTNFSSSHDHFRVLALARGV 2033
+ ++Q P++G + G+ TS F+ I Q V ++ +S D F ++ G
Sbjct: 2348 FTIVQPPRHGTIERTSNGQHFHLTSTFTMKDIYQNRVSYSHDGSNSLKDRF-TFTVSDGT 2406
Query: 2034 NASAVV 2039
N ++
Sbjct: 2407 NPFFII 2412
Score = 171 bits (432), Expect = 1e-41
Identities = 286/1247 (22%), Positives = 498/1247 (39%), Gaps = 190/1247 (15%)
Query: 430 QLLTISPLVVAEGGTAWLEWRHVQPTLDLMEAELRKSQVLFSVTRG-ARHGELEL----- 483
QL+ S + V EGG + R +Q AE ++++ +T+ + GE+ L
Sbjct: 1330 QLVANSMVWVPEGGMLQITNRILQAEAPGASAE----EIIYKITQDYPQFGEVVLLVNMP 1385
Query: 484 -DIPGAQARKM-----------FTLLDVVNRKARFIHDGSEDTSDQLVLEVSVTARVPMP 531
D P + + + FT D+ + H G+ SD EVS +
Sbjct: 1386 ADSPADEGQHLPDGRTATPTSTFTQQDINEGIVWYRHSGAPAQSDSFRFEVSSASNAQT- 1444
Query: 532 SCLRRGQTYLLPIQVNPVNDPP---------HIIFPHGSLMVILEHT------QKPLGPE 576
R ++++ I + P H+ L VI H+ +KP G
Sbjct: 1445 ----RLESHMFNIAILPQTPEAPKVSLEASLHMTAREDGLTVIQPHSLSFINSEKPSGKI 1500
Query: 577 VFQAYDPDSACEGLTFQVLGTSSGLPVERRDQPGEPATEFSCRELEAGSLVYVHRGGPA- 635
V+ P +G+ +E RD P P F+ ++ G ++Y R PA
Sbjct: 1501 VYNITLPLHPNQGI------------IEHRDHPHSPIRYFTQEDINQGKVMY--RPPPAA 1546
Query: 636 ---QDLT--------------FRVSDGLQASPPATLKVVAIRPAIQ---IHRSTGLRLAQ 675
Q+L F VSDG SP L + + P+ Q + + T RLA
Sbjct: 1547 PHLQELMAFSFAGLPESVKFHFTVSDGEHTSPEMVL-TIHLLPSDQQLPVFQVTAPRLAV 1605
Query: 676 GSAMPILPANLSVETNAVGQDVSVLFRVTGALQFGELQKQGAGGVEGAEWWAT-QAFHQR 734
V +A + F + Q G L K A E AT F
Sbjct: 1606 SPGGSTSVGLQVVVRDAETAPKELFFELRRPPQHGVLLKHTA---EFRRPMATGDTFTYE 1662
Query: 735 DVEQGRVRYLSTDPQHHAYDTVENLALEVQVGQEI-LSNLSFPVTIQRATVWMLRLEP-- 791
DVE+ ++Y+ H T E+ ++E+ V + ++ L V + + RL
Sbjct: 1663 DVEKNALQYI-----HDGSSTRED-SMEISVTDGLTVTMLEVRVEVSLSEDRGPRLAAGS 1716
Query: 792 ---LHTQNTQQETLTTAHLEATLEEAGPSPPTFHYEVVQAPRKGNL-QLQGTR---LSDG 844
+ + +T +HL A ++++ P P + ++ P G L ++ G+ LS+
Sbjct: 1717 SLSITVASKSTAIITRSHL-AYVDDSSPDPEIW-IQLNYLPSYGTLLRISGSEVEELSEV 1774
Query: 845 QGFTQDDIQAGRVTYGATARAS-EAVEDTFRFRVTAPPYF---SPLYTFPIHIGGDPDAP 900
FT +DI ++ Y A V D+F F V+ + + ++T I +P
Sbjct: 1775 SNFTMEDINNKKIRYSAVFETDGHLVTDSFYFSVSDMDHNHLDNQIFTIMITPAENPPPV 1834
Query: 901 VLTNVLLVVPEGGEGVLSADHLFVKSLNS---ASYLYEVMERPRHGRLAWRGTQDK---- 953
+ L+ V EGG LS H F + + ++ P++G + GT D+
Sbjct: 1835 IAFADLITVDEGGRAPLSFHHFFATDDDDNLQRDAIIKLSALPKYGCIENTGTGDRFGPE 1894
Query: 954 --TTMVTSFTNEDLLRGRLVY---QHDDSETTEDDIPFVATRQGESSGDMAWEEVRGVFR 1008
+ + SF +D+L + Y H+ E T D F S + E+ +
Sbjct: 1895 TASDLEASFPIQDVLENYIYYFQSVHESIEPTHDIFSFYV------SDGTSRSEIHSI-N 1947
Query: 1009 VAIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSI 1068
+ I+ ND P T+ + V +++ ++ D D+ + VLT+K G +
Sbjct: 1948 ITIERKNDEPPRMTLQPL-RVQLSSGVVISNSSLSLQDLDTPDNELIFVLTKKPD-HGHV 2005
Query: 1069 VAVDEPTRPIYR---------FTQEDLRKRRVLFVHS--GADRGWIQLQVSDGQHQATAL 1117
+ + P+ FT +D+ V +V S G Q ++DG H T
Sbjct: 2006 LWRQTASEPLENGRVLVQGSTFTYQDILAGLVGYVPSVPGMVVDEFQFSLTDGLHVDTGR 2065
Query: 1118 LEVQASEPYLRVANGSSLVVPQGGQGTIDTAVLHLDTNL---DIRSGD-EVHYHVTAGPR 1173
+++ P ++ L + QG Q + + + +L DI S D +V Y + P
Sbjct: 2066 MKIYTELP---ASDTPHLAINQGLQLSAGSVARITEQHLKVTDIDSDDHQVMYIMKEDPG 2122
Query: 1174 WG--QLVRAGQ--------PATAFSQQDLLDGAVLYSHNGSLSPRDTMAFSVEA----GP 1219
G Q+++ G P +F+Q D+ G YSH G+ P + AF + G
Sbjct: 2123 AGRLQMMKHGNLEQISIKGPIRSFTQADISQGQPEYSH-GTGEPGGSFAFKFDVVDGEGN 2181
Query: 1220 VHTDATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEIRRDQLEAAQEAVPPADIVFSVK 1279
D + ++I LE P+ + +K + + + +I QL A + P ++++ +
Sbjct: 2182 RLIDKSFSISI-LEDKSPPV-ITTNKGLVLDENSVKKITTLQLSATDQDSGPTELIYRIT 2239
Query: 1280 SPPSAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLYLHS-RPEAWSDAFSLDVAS 1338
P G+L + + + SF+Q + + V Y+HS E SDAFS ++
Sbjct: 2240 RQPQLGHLEHAASPGIQ--------ISSFTQADLTSRNVQYVHSSEAEKHSDAFSFTLSD 2291
Query: 1339 GLGAPLEGVLVELEVLPAAIPLEAQNFS--VPEGGSLTLAPPLLRVSGPYFPTLLGLSLQ 1396
G+ + + L + ++P+ QN V EG T+ L+ ++
Sbjct: 2292 GVSEVTQTFHITLHPVDDSLPV-VQNLGMRVQEGMRKTITEFELKAVDADTEAE-SVTFT 2349
Query: 1397 VLEPPQHGALQK-EDGPQARTLSAFSWRMVEEQLIRYVHDGSETLTDSFV---------- 1445
+++PP+HG +++ +G S F+ + + + + Y HDGS +L D F
Sbjct: 2350 IVQPPRHGTIERTSNGQHFHLTSTFTMKDIYQNRVSYSHDGSNSLKDRFTFTVSDGTNPF 2409
Query: 1446 -LMANASEMDRQSHPVAFTVTVLPVNDQPPILTTNTGLQMWE----GATAPIPAEALRST 1500
++ + + P F V +LPV+D P + TN GLQ E AT I + L +
Sbjct: 2410 FIIEEGGKEIMTAAPQPFRVDILPVDDGTPRIVTNLGLQWLEYMDGKATNLITKKELLTM 2469
Query: 1501 DGDSGSEDLVYTIEQ-PSNGRVVLRGAPGTEVRSFTQAQLDGGLVLF 1546
D D+ LVY I P +G V + PG +FTQ ++ GL+ +
Sbjct: 2470 DPDTEDAQLVYEITTGPKHGFVENKLQPGRAAATFTQEDVNLGLIRY 2516
Score = 156 bits (395), Expect = 2e-37
Identities = 334/1495 (22%), Positives = 571/1495 (38%), Gaps = 217/1495 (14%)
Query: 555 IIFPHGSLMVILEHTQKPLGPEVFQAYDPDSACEGLTFQVLGTSSG----LPVERRDQPG 610
+I P GS+ KPL + D + E L F V+ T + L ++
Sbjct: 1110 LILPIGSI--------KPLDFSLLNVQDQEGRVEDLLFHVVSTPTNGQLVLSRNGKEVQL 1161
Query: 611 EPATEFSCRELEAGSLVYVHRGGPAQD--LTFRVSDGLQASPPATLKVVAIRP-AIQIHR 667
+ A FS +++ + +VH + L ++SD S P + + A A + R
Sbjct: 1162 DKAGRFSWKDVNEKKVRFVHSKEKLRKGYLFLKISDQQFFSEPQLINIQAFSTQAPYVLR 1221
Query: 668 STGLRLAQGSAMPILPANLSVETNAVGQDVSVLFRVTGALQFGELQKQGAGGVEGAEWWA 727
+ L +++G I L + + QDV + + G+L +
Sbjct: 1222 NEVLHISRGERATITTQMLDIRDDDNPQDVVI--EIIDPPLHGQLLQ------------- 1266
Query: 728 TQAFHQRDVEQGRVRYLSTDPQHHAYD----TVENLALEVQVGQEILSNLSFPVT----- 778
T + Q ++ LS H+A+D T + L+ G N+ F V
Sbjct: 1267 TLQSPATPIYQFQLDELSRGLLHYAHDGSDSTSDVAVLQANDGHSF-HNILFQVKTVPQN 1325
Query: 779 ------IQRATVWMLRLEPLHTQNTQQETLTTAHLEATLEEAGPSPPTFHYEVVQA-PRK 831
+ + VW+ L +T L+A E G S Y++ Q P+
Sbjct: 1326 DRGLQLVANSMVWVPEGGMLQ--------ITNRILQA--EAPGASAEEIIYKITQDYPQF 1375
Query: 832 GNLQL-----------QGTRLSDGQG------FTQDDIQAGRVTYGATARASEAVEDTFR 874
G + L +G L DG+ FTQ DI G V Y + +++ D+FR
Sbjct: 1376 GEVVLLVNMPADSPADEGQHLPDGRTATPTSTFTQQDINEGIVWYRHSGAPAQS--DSFR 1433
Query: 875 FRVTAPPYF-----SPLYTFPIHIGGDPDAPVLT---NVLLVVPEGGEGVLSADHL-FVK 925
F V++ S ++ I + P+AP ++ ++ + E G V+ L F+
Sbjct: 1434 FEVSSASNAQTRLESHMFNIAI-LPQTPEAPKVSLEASLHMTAREDGLTVIQPHSLSFIN 1492
Query: 926 SLNSASYLYEVMERPRHGRLAWRGTQDKT-TMVTSFTNEDLLRGRLVYQHDDSETTEDDI 984
S + + + P H +D + + FT ED+ +G+++Y+ + ++
Sbjct: 1493 SEKPSGKIVYNITLPLHPNQGIIEHRDHPHSPIRYFTQEDINQGKVMYRPPPAAPHLQEL 1552
Query: 985 ---------PFVATRQGESSGDMAWEEVRGVFRVAIQPVNDHAPV-QTISRIFHVARGGR 1034
V S G+ E+ V + + P + PV Q + V+ GG
Sbjct: 1553 MAFSFAGLPESVKFHFTVSDGEHTSPEM--VLTIHLLPSDQQLPVFQVTAPRLAVSPGGS 1610
Query: 1035 RLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIVAVDEPTRPIYR---FTQEDLRKRRV 1091
+ V DA++ + L R + E RP+ FT ED+ K +
Sbjct: 1611 TSVGLQ-VVVRDAETAPKELFFELRRPPQHGVLLKHTAEFRRPMATGDTFTYEDVEKNAL 1669
Query: 1092 LFVHSGADRGWIQLQVSDGQHQATALLEVQ-----ASEPYLRVANGSSLVVPQGGQGTID 1146
++H G+ +++S +LEV+ + + R+A GSSL + + T
Sbjct: 1670 QYIHDGSSTREDSMEISVTDGLTVTMLEVRVEVSLSEDRGPRLAAGSSLSITVASKSTAI 1729
Query: 1147 TAVLHLDTNLDIRSGDEVHYHVTAGPRWGQLVRAG-------QPATAFSQQDLLDGAVLY 1199
HL D E+ + P +G L+R + F+ +D+ + + Y
Sbjct: 1730 ITRSHLAYVDDSSPDPEIWIQLNYLPSYGTLLRISGSEVEELSEVSNFTMEDINNKKIRY 1789
Query: 1200 SH----NGSLSPRDTMAFSV-EAGPVHTDATLQVTIALEGPLAPLKLVRHKKIYVFQGEA 1254
S +G L D+ FSV + H D + + P + I V +G
Sbjct: 1790 SAVFETDGHLVT-DSFYFSVSDMDHNHLDNQIFTIMITPAENPPPVIAFADLITVDEGGR 1848
Query: 1255 AEIRRDQLEAAQEAVP-PADIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQSFSQEAV 1313
A + A + D + + + P G + G + D SF + V
Sbjct: 1849 APLSFHHFFATDDDDNLQRDAIIKLSALPKYGCIENTGTGDRFGPETASDLEASFPIQDV 1908
Query: 1314 DTGRVLY---LHSRPEAWSDAFSLDVASGLGAPLEGVLVELEVLPAAIPLEAQNFSVPEG 1370
+ Y +H E D FS V+ G E+ I +E +N P
Sbjct: 1909 LENYIYYFQSVHESIEPTHDIFSFYVSDGTSRS--------EIHSINITIERKNDEPPR- 1959
Query: 1371 GSLTLAPPLLRVSGPYFPTLLGLSLQVLEPPQ------------HGAL--------QKED 1410
+TL P +++S + LSLQ L+ P HG + E+
Sbjct: 1960 --MTLQPLRVQLSSGVVISNSSLSLQDLDTPDNELIFVLTKKPDHGHVLWRQTASEPLEN 2017
Query: 1411 GPQARTLSAFSWRMVEEQLIRYVHDGSETLTDSFVL-MANASEMDRQSHPVAFTVTVLPV 1469
G S F+++ + L+ YV + D F + + +D + T LP
Sbjct: 2018 GRVLVQGSTFTYQDILAGLVGYVPSVPGMVVDEFQFSLTDGLHVDTGRMKI---YTELPA 2074
Query: 1470 NDQPPILTTNTGLQMWEGATAPIPAEALRSTDGDSGSEDLVYTI-EQPSNGRVVLRGAPG 1528
+D P L N GLQ+ G+ A I + L+ TD DS ++Y + E P GR+ +
Sbjct: 2075 SDTPH-LAINQGLQLSAGSVARITEQHLKVTDIDSDDHQVMYIMKEDPGAGRLQMMKHGN 2133
Query: 1529 TE-------VRSFTQAQLDGGLVLFSHRGTLDGG---FRFRLSDGEHT---SPGHFFRVT 1575
E +RSFTQA + G +SH GG F+F + DGE +
Sbjct: 2134 LEQISIKGPIRSFTQADISQGQPEYSHGTGEPGGSFAFKFDVVDGEGNRLIDKSFSISIL 2193
Query: 1576 AQKQ--VLLSLKGSQTLTVCPGSVQPLSSQTLRASSSAGTDPQLLLYRVVRGPQLGRLFH 1633
K V+ + KG L + SV+ +++ L A+ + P L+YR+ R PQLG L H
Sbjct: 2194 EDKSPPVITTNKG---LVLDENSVKKITTLQLSATDQ-DSGPTELIYRITRQPQLGHLEH 2249
Query: 1634 AQQDSTGEALVNFTQAEVYAGNILYEHEMPPEPFWEAHDTLELQLSSPPARDVAATLAVA 1693
A S G + +FTQA++ + N+ Y H E + D LS + T
Sbjct: 2250 AA--SPGIQISSFTQADLTSRNVQYVHSSEAE---KHSDAFSFTLSDGVSE---VTQTFH 2301
Query: 1694 VSFEAACPQRPSHLWKNKGLWVPEGQRARITVAALDASNLLASVPSPQRSEHDVLFQVTQ 1753
++ P + +N G+ V EG R IT L A + S V F + Q
Sbjct: 2302 ITLHPVDDSLP--VVQNLGMRVQEGMRKTITEFELKAVDADTEAES-------VTFTIVQ 2352
Query: 1754 FPSRGQLLVSEEPLHAGQPH-FLQSQLAAGQLVYAHGGGGTQQDGFHFRAH--------- 1803
P G + + H F + ++ Y+H G + +D F F
Sbjct: 2353 PPRHGTIERTSNGQHFHLTSTFTMKDIYQNRVSYSHDGSNSLKDRFTFTVSDGTNPFFII 2412
Query: 1804 LQGPAGASVAGPQTSEAFAITVRDVNERPPQPQASVPLR----LTRGSRAPISRAQLSVV 1859
+G A PQ F + + V++ P+ ++ L+ + + I++ +L +
Sbjct: 2413 EEGGKEIMTAAPQP---FRVDILPVDDGTPRIVTNLGLQWLEYMDGKATNLITKKELLTM 2469
Query: 1860 DPDSAPGEIEYEVQRAPHNGFL-SLVGGGLGPVTRFTQADVDSGRLAFVANGSSV 1913
DPD+ ++ YE+ P +GF+ + + G T FTQ DV+ G + +V + +
Sbjct: 2470 DPDTEDAQLVYEITTGPKHGFVENKLQPGRAAAT-FTQEDVNLGLIRYVLHKEKI 2523
Score = 152 bits (385), Expect = 3e-36
Identities = 282/1305 (21%), Positives = 501/1305 (38%), Gaps = 139/1305 (10%)
Query: 456 LDLMEAELRKSQVLFSVTRGARHGELELDIPGAQARK----MFTLLDVVNRKARFIHDGS 511
L++ + E R +LF V +G+L L G + + F+ DV +K RF+H
Sbjct: 1125 LNVQDQEGRVEDLLFHVVSTPTNGQLVLSRNGKEVQLDKAGRFSWKDVNEKKVRFVHSKE 1184
Query: 512 EDTSDQLVLEVSVTARVPMPSCLRRGQTYLLPIQVNPVNDPPHIIFPHGSLMVILEHTQK 571
+ L L++S P L+ IQ P+++ ++ I +
Sbjct: 1185 KLRKGYLFLKISDQQFFSEPQ--------LINIQAFS-TQAPYVL--RNEVLHISRGERA 1233
Query: 572 PLGPEVFQAYDPDSACEGLTFQVLGTSSGLPVERRDQPGEPATEFSCRELEAGSLVYVHR 631
+ ++ D D+ + + + G ++ P P +F EL G L Y H
Sbjct: 1234 TITTQMLDIRDDDNPQDVVIEIIDPPLHGQLLQTLQSPATPIYQFQLDELSRGLLHYAHD 1293
Query: 632 GGPAQDLTFRVSDGLQASPPATLKVVAIRPAIQIHRSTGLRLAQGSAMPILPANLSVETN 691
G D T V+ LQA+ + + + GL+L S + + + TN
Sbjct: 1294 G---SDSTSDVA-VLQANDGHSFHNILFQVKTVPQNDRGLQLVANSMVWVPEGGMLQITN 1349
Query: 692 AVGQDVS-------VLFRVTGAL-QFGEL-----------QKQGAGGVEGAEWWATQAFH 732
+ Q + +++++T QFGE+ +G +G T F
Sbjct: 1350 RILQAEAPGASAEEIIYKITQDYPQFGEVVLLVNMPADSPADEGQHLPDGRTATPTSTFT 1409
Query: 733 QRDVEQGRVRYLSTDPQHHAYDTVENLALEVQVGQEILSNLSFPVTI--QRATVWMLRLE 790
Q+D+ +G V Y + + D+ Q L + F + I Q + LE
Sbjct: 1410 QQDINEGIVWYRHSGAPAQS-DSFRFEVSSASNAQTRLESHMFNIAILPQTPEAPKVSLE 1468
Query: 791 PLHTQNTQQETLTT--AHLEATLEEAGPSPP-TFHYEVVQAPRKGNLQLQGTRLSDGQGF 847
+++ LT H + + PS ++ + P +G ++ + S + F
Sbjct: 1469 ASLHMTAREDGLTVIQPHSLSFINSEKPSGKIVYNITLPLHPNQGIIEHRDHPHSPIRYF 1528
Query: 848 TQDDIQAGRVTYGATARASEAVE------------DTFRFRVTAPPYFSPLYTFPIH-IG 894
TQ+DI G+V Y A E F F V+ + SP IH +
Sbjct: 1529 TQEDINQGKVMYRPPPAAPHLQELMAFSFAGLPESVKFHFTVSDGEHTSPEMVLTIHLLP 1588
Query: 895 GDPDAPV--LTNVLLVVPEGGEGVLSADHLFVKSLNSA--SYLYEVMERPRHGRLAWRGT 950
D PV +T L V GG + + V+ +A +E+ P+HG L
Sbjct: 1589 SDQQLPVFQVTAPRLAVSPGGSTSVGL-QVVVRDAETAPKELFFELRRPPQHGVLLKHTA 1647
Query: 951 QDKTTMVT--SFTNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGVFR 1008
+ + M T +FT ED+ + L Y HD S T ED + T + EV R
Sbjct: 1648 EFRRPMATGDTFTYEDVEKNALQYIHDGSSTREDSMEISVT----DGLTVTMLEV----R 1699
Query: 1009 VAIQPVNDHAP--VQTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFG 1066
V + D P S VA ++T +A+ D S + + L +G
Sbjct: 1700 VEVSLSEDRGPRLAAGSSLSITVASKSTAIITRSHLAYVDDSSPDPEIWIQLNYLP-SYG 1758
Query: 1067 SIVAVD----EPTRPIYRFTQEDLRKRRVLFV-------HSGADRGWIQLQVSDGQH--- 1112
+++ + E + FT ED+ +++ + H D + + D H
Sbjct: 1759 TLLRISGSEVEELSEVSNFTMEDINNKKIRYSAVFETDGHLVTDSFYFSVSDMDHNHLDN 1818
Query: 1113 QATALLEVQASEPYLRVANGSSLVVPQGGQGTIDTAVLHLDTNLDIRSGDEVHYHVTAGP 1172
Q ++ A P +A + V +GG+ + + D D + ++A P
Sbjct: 1819 QIFTIMITPAENPPPVIAFADLITVDEGGRAPLSFHHFFATDDDDNLQRDAI-IKLSALP 1877
Query: 1173 RWGQLVRAGQ-----PATA------FSQQDLLDGAVLY--SHNGSLSP-RDTMAFSVEAG 1218
++G + G P TA F QD+L+ + Y S + S+ P D +F V G
Sbjct: 1878 KYGCIENTGTGDRFGPETASDLEASFPIQDVLENYIYYFQSVHESIEPTHDIFSFYVSDG 1937
Query: 1219 PVHTDA-TLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEIRRDQLEAAQEAVPPADIVFS 1277
++ ++ +TI + P ++ ++ + G I L P +++F
Sbjct: 1938 TSRSEIHSINITIERKNDEPPRMTLQPLRVQLSSG--VVISNSSLSLQDLDTPDNELIFV 1995
Query: 1278 VKSPPSAGYLVMVSRGALADEPPSLDPV----QSFSQEAVDTGRVLYLHSRPEAWSDAFS 1333
+ P G+++ A EP V +F+ + + G V Y+ S P D F
Sbjct: 1996 LTKKPDHGHVLW---RQTASEPLENGRVLVQGSTFTYQDILAGLVGYVPSVPGMVVDEFQ 2052
Query: 1334 LDVASGLGAPLEGVLVELEVLPAAIPLEAQNFSVPEGGSLTLAPPLLRVSGPYFPT--LL 1391
+ GL + + E LPA+ + + ++ +G L+ A + R++ + +
Sbjct: 2053 FSLTDGLHVDTGRMKIYTE-LPAS---DTPHLAINQGLQLS-AGSVARITEQHLKVTDID 2107
Query: 1392 GLSLQVL----EPPQHGALQKEDGPQARTLS------AFSWRMVEEQLIRYVHDGSETLT 1441
QV+ E P G LQ +S +F+ + + Y H G+
Sbjct: 2108 SDDHQVMYIMKEDPGAGRLQMMKHGNLEQISIKGPIRSFTQADISQGQPEYSH-GTGEPG 2166
Query: 1442 DSFVLMANASEMD-RQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEALRST 1500
SF + + + + +F++++L + PP++TTN GL + E + I L +T
Sbjct: 2167 GSFAFKFDVVDGEGNRLIDKSFSISILE-DKSPPVITTNKGLVLDENSVKKITTLQLSAT 2225
Query: 1501 DGDSGSEDLVYTI-EQPSNGRVVLRGAPGTEVRSFTQAQLDGGLVLFSHRGTLD---GGF 1556
D DSG +L+Y I QP G + +PG ++ SFTQA L V + H + F
Sbjct: 2226 DQDSGPTELIYRITRQPQLGHLEHAASPGIQISSFTQADLTSRNVQYVHSSEAEKHSDAF 2285
Query: 1557 RFRLSDGEHTSPGHFFRVTAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASSSAGTDPQ 1616
F LSDG F L + + + V G + ++ L+A A T+ +
Sbjct: 2286 SFTLSDGVSEVTQTFHITLHPVDDSLPVVQNLGMRVQEGMRKTITEFELKA-VDADTEAE 2344
Query: 1617 LLLYRVVRGPQLGRLFHAQQDSTGEALVNFTQAEVYAGNILYEHE 1661
+ + +V+ P+ G + FT ++Y + Y H+
Sbjct: 2345 SVTFTIVQPPRHGTIERTSNGQHFHLTSTFTMKDIYQNRVSYSHD 2389
>gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens]
Length = 1642
Score = 79.3 bits (194), Expect = 4e-14
Identities = 94/358 (26%), Positives = 138/358 (38%), Gaps = 45/358 (12%)
Query: 50 DLQLQFSTSQPEALLLLAAGPADHLLLQLYSGRLQVRLVLGQEELR-LQTPAETLLSDSI 108
++ L F T Q L+L AD++ L L SG + + + LG L P +D+
Sbjct: 289 EITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNA 348
Query: 109 PHTVVLT--------VVEGWATLSVDGFLNASSAVPG--APLEVPYGLFVGGT-GTLGLP 157
H V +T + T+SVDG L + L ++GG+ T LP
Sbjct: 349 WHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLP 408
Query: 158 YLRGTSRPLRGCLHAATLNGRSLLRPLTPDVHEGCAE-------EFSASDDVALG---FS 207
S GCL L+ EG + F D AL F
Sbjct: 409 G-SPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFE 467
Query: 208 GPHSLAAFPAWGTQDEGTLEFTLTTQSRQAPLAFQAGGR------------RGDFIYVDI 255
P + A P W + G++ T L F G R R D+ +++
Sbjct: 468 SPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMEL 527
Query: 256 FEGHLRAVVEKGQGTVLLH-NSVPVADGQPHEVSVHINAHRLEISVDQYPTHTSNRGVLS 314
+GHL +++ G G + L +S V DG+ V + + ISV+ T G
Sbjct: 528 LDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSE 587
Query: 315 YLEPRGSLLLGGLDAEASRHLQEHRLGLTPEATNASL----LGCMEDLSVNGQRRGLR 368
L+ L LGGL E R L L PE A+L +GC+ DL ++G+ R LR
Sbjct: 588 ILDLESELYLGGL-PEGGR----VDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLR 640
Score = 52.8 bits (125), Expect = 4e-06
Identities = 76/347 (21%), Positives = 134/347 (38%), Gaps = 56/347 (16%)
Query: 36 NHLEVPVATALTDIDLQLQFSTSQPEALLLLAAGPA-DHLLLQLYSGRLQVRLVLGQEEL 94
++L + A + L QF T+ P+ LLL +G D ++++L G + LG
Sbjct: 887 SYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPS 946
Query: 95 RLQTPAETLLSDSIPHTVVLTVVEGWA-TLSVDGFLNASSAVPGAPLEVPYGLFVGGTGT 153
++ ++ ++D+ H VV++ G TL +D + L++ L++GG
Sbjct: 947 LMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSK 1006
Query: 154 ---LGLPYLRGTSRPLRGCLHAATLNGRSLLRPLTPD-------VHEG-------CAEEF 196
LP L + +GCL + LNGR L L D V G C EE
Sbjct: 1007 NMFSNLPKLVASRDGFQGCLASVDLNGR--LPDLIADALHRIGQVERGCDGPSTTCTEES 1064
Query: 197 SASDDVAL----GFSGPHSLAAFPAWGTQDEGT--------------------------- 225
A+ V L GF+ ++ ++ D GT
Sbjct: 1065 CANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRMDR 1124
Query: 226 LEFTLTTQSRQAPLA-FQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLHN-SVPVADGQ 283
L +T R A L + GD++ + I +G + + G + + + V+DG+
Sbjct: 1125 LAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGK 1184
Query: 284 PHEVSVHINAHRLEISVDQYPTHTSNRG--VLSYLEPRGSLLLGGLD 328
H V + + VD +P + L+ + ++ +GG D
Sbjct: 1185 YHVVRFTRSGGNATLQVDSWPVNERYPAGRQLTIFNSQAAIKIGGRD 1231
Score = 50.1 bits (118), Expect = 3e-05
Identities = 85/369 (23%), Positives = 146/369 (39%), Gaps = 61/369 (16%)
Query: 25 RLASAASFFGENHLEVPVATAL-TDI-DLQLQFSTSQPEALLLLAAG--PADHLLLQLYS 80
R A+ S+ G ++++ + A+ T+ D+ L+F + + L++ AD L L+L
Sbjct: 697 REATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDG 756
Query: 81 GRLQVRLVLGQEELRLQTPAETLLSDSIPHTVVLTVVEGWATLSVDGFLNASSAVPGAPL 140
G++++ + LG+ L A L+D+ HTV + LSVD + + GA +
Sbjct: 757 GQMKLTVNLGKGPETLF--AGHKLNDNEWHTVRVVRRGKSLQLSVDN-VTVEGQMAGAHM 813
Query: 141 EVPY------------------GLFVGGTGTL---GLPYLRGTSRPLRGCLHAATLNGRS 179
+ + F+G L G PY+ + G + LN R
Sbjct: 814 RLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYM---DQCKDGDITYCELNARF 870
Query: 180 LLRPLTPDVHEGCAEEFSASDDVALGFSGPHSLAAFPAWGTQDEGTLEFTLTTQSRQAPL 239
LR + D + F S A L F T + L
Sbjct: 871 GLRAIVAD---------------PVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLL 915
Query: 240 AFQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLL--HNSVPVADGQPHEVSVHI---NAH 294
F +G DFI +++ +G++ V + G G L+ ++ PV D Q H V V N H
Sbjct: 916 LFNSGNGN-DFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVH 974
Query: 295 RLEISVDQYPTHTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLTPEATNASLLGC 354
L+I H++ L+ +G L +GGL +L + A+ GC
Sbjct: 975 TLKIDSRTVTQHSNG---ARNLDLKGELYIGGLSKNMFSNLPK------LVASRDGFQGC 1025
Query: 355 MEDLSVNGQ 363
+ + +NG+
Sbjct: 1026 LASVDLNGR 1034
Score = 41.2 bits (95), Expect = 0.012
Identities = 33/122 (27%), Positives = 51/122 (41%), Gaps = 2/122 (1%)
Query: 208 GPHSLAAFPAW-GTQDEGTLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLR-AVVE 265
GP A + W G G L F+L T + +A L + G DF+ + + +G LR
Sbjct: 34 GPGQWARYARWAGAASSGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTL 93
Query: 266 KGQGTVLLHNSVPVADGQPHEVSVHINAHRLEISVDQYPTHTSNRGVLSYLEPRGSLLLG 325
L PVAD + H V + +A R ++VD R ++ L +G
Sbjct: 94 SCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVG 153
Query: 326 GL 327
G+
Sbjct: 154 GI 155
>gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens]
Length = 1712
Score = 74.7 bits (182), Expect = 1e-12
Identities = 94/365 (25%), Positives = 138/365 (37%), Gaps = 52/365 (14%)
Query: 50 DLQLQFSTSQPEALLLLAAGPADHLLLQLYSGRLQVRLVLGQEELR-LQTPAETLLSDSI 108
++ L F T Q L+L AD++ L L SG + + + LG L P +D+
Sbjct: 313 EITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNA 372
Query: 109 PHTVVLT---------------VVEGWATLSVDGFLNASSAVPG--APLEVPYGLFVGGT 151
H V +T + T+SVDG L + L ++GG+
Sbjct: 373 WHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGS 432
Query: 152 -GTLGLPYLRGTSRPLRGCLHAATLNGRSLLRPLTPDVHEGCAE-------EFSASDDVA 203
T LP S GCL L+ EG + F D A
Sbjct: 433 PNTADLPG-SPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAA 491
Query: 204 LG---FSGPHSLAAFPAWGTQDEGTLEFTLTTQSRQAPLAFQAGGR------------RG 248
L F P + A P W + G++ T L F G R R
Sbjct: 492 LDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRA 551
Query: 249 DFIYVDIFEGHLRAVVEKGQGTVLLH-NSVPVADGQPHEVSVHINAHRLEISVDQYPTHT 307
D+ +++ +GHL +++ G G + L +S V DG+ V + + ISV+ T
Sbjct: 552 DYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPF 611
Query: 308 SNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLTPEATNASL----LGCMEDLSVNGQ 363
G L+ L LGGL E R L L PE A+L +GC+ DL ++G+
Sbjct: 612 LATGDSEILDLESELYLGGL-PEGGR----VDLPLPPEVWTAALRAGYVGCVRDLFIDGR 666
Query: 364 RRGLR 368
R LR
Sbjct: 667 SRDLR 671
Score = 52.0 bits (123), Expect = 7e-06
Identities = 72/323 (22%), Positives = 125/323 (38%), Gaps = 54/323 (16%)
Query: 36 NHLEVPVATALTDIDLQLQFSTSQPEALLLLAAGPA-DHLLLQLYSGRLQVRLVLGQEEL 94
++L + A + L QF T+ P+ LLL +G D ++++L G + LG
Sbjct: 927 SYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPS 986
Query: 95 RLQTPAETLLSDSIPHTVVLTVVEGWA-TLSVDGFLNASSAVPGAPLEVPYGLFVGGTGT 153
++ ++ ++D+ H VV++ G TL +D + L++ L++GG
Sbjct: 987 LMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSK 1046
Query: 154 ---LGLPYLRGTSRPLRGCLHAATLNGRSLLRPLTPD-------VHEG-------CAEEF 196
LP L + +GCL + LNGR L L D V G C EE
Sbjct: 1047 NMFSNLPKLVASRDGFQGCLASVDLNGR--LPDLIADALHRIGQVERGCDGPSTTCTEES 1104
Query: 197 SASDDVAL----GFSGPHSLAAFPAWGTQDEGT--------------------------- 225
A+ V L GF+ ++ ++ D GT
Sbjct: 1105 CANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRMDR 1164
Query: 226 LEFTLTTQSRQAPLA-FQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLHN-SVPVADGQ 283
L +T R A L + GD++ + I +G + + G + + + V+DG+
Sbjct: 1165 LAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGK 1224
Query: 284 PHEVSVHINAHRLEISVDQYPTH 306
H V + + VD +P +
Sbjct: 1225 YHVVRFTRSGGNATLQVDSWPVN 1247
Score = 47.4 bits (111), Expect = 2e-04
Identities = 88/378 (23%), Positives = 148/378 (39%), Gaps = 70/378 (18%)
Query: 25 RLASAASFFGENHLEVPVATAL-TDI-DLQLQFSTSQPEALLLLAAG--PADHLLLQLYS 80
R A+ S+ G ++++ + A+ T+ D+ L+F + + L++ AD L L+L
Sbjct: 728 REATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDG 787
Query: 81 GRLQVRLVLGQEELRL----QTPAETL-----LSDSIPHTVVLTVVEGWATLSVDGFLNA 131
G Q++L + + LR+ ETL L+D+ HTV + LSVD +
Sbjct: 788 G--QMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDN-VTV 844
Query: 132 SSAVPGAPLEVPY------------------GLFVGGTGTL---GLPYLRGTSRPLRGCL 170
+ GA + + + F+G L G PY+ + G +
Sbjct: 845 EGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYM---DQCKDGDI 901
Query: 171 HAATLNGRSLLRPLTPDVHEGCAEEFSASDDVALGFSGPHSLAAFPAWGTQDEGTLEFTL 230
LN R LR + D + F S A L F
Sbjct: 902 TYCELNARFGLRAIVAD---------------PVTFKSRSSYLALATLQAYASMHLFFQF 946
Query: 231 TTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLL--HNSVPVADGQPHEVS 288
T + L F +G DFI +++ +G++ V + G G L+ ++ PV D Q H V
Sbjct: 947 KTTAPDGLLLFNSGNGN-DFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVV 1005
Query: 289 VHI---NAHRLEISVDQYPTHTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLTPE 345
V N H L+I H++ L+ +G L +GGL +L +
Sbjct: 1006 VSRDPGNVHTLKIDSRTVTQHSNG---ARNLDLKGELYIGGLSKNMFSNLPK------LV 1056
Query: 346 ATNASLLGCMEDLSVNGQ 363
A+ GC+ + +NG+
Sbjct: 1057 ASRDGFQGCLASVDLNGR 1074
Score = 41.2 bits (95), Expect = 0.012
Identities = 33/122 (27%), Positives = 51/122 (41%), Gaps = 2/122 (1%)
Query: 208 GPHSLAAFPAW-GTQDEGTLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLR-AVVE 265
GP A + W G G L F+L T + +A L + G DF+ + + +G LR
Sbjct: 34 GPGQWARYARWAGAASSGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTL 93
Query: 266 KGQGTVLLHNSVPVADGQPHEVSVHINAHRLEISVDQYPTHTSNRGVLSYLEPRGSLLLG 325
L PVAD + H V + +A R ++VD R ++ L +G
Sbjct: 94 SCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVG 153
Query: 326 GL 327
G+
Sbjct: 154 GI 155
>gi|14149613 neurexin 1 isoform alpha1 precursor [Homo sapiens]
Length = 1477
Score = 72.4 bits (176), Expect = 5e-12
Identities = 85/363 (23%), Positives = 137/363 (37%), Gaps = 54/363 (14%)
Query: 50 DLQLQFSTSQPEALLLLAAGPADHLLLQLYSGRLQVRLVLGQEELR-LQTPAETLLSDSI 108
++ L F T Q L+L AD++ L L +G + + + LG L P +D+
Sbjct: 307 EITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNA 366
Query: 109 PHTVVLT--------VVEGWATLSVDGFLNASSAVPG--APLEVPYGLFVGGT-GTLGLP 157
H V +T + T+SVDG L + L +VGG+ T LP
Sbjct: 367 WHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLP 426
Query: 158 YLRGTSRPLRGCLHAATLNGRSLLRPLTPDVHEGC------------AEEFSASDDVALG 205
S GCL + L+ +G E + D +
Sbjct: 427 G-SPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPIT-- 483
Query: 206 FSGPHSLAAFPAWGTQDEGTLEFTLTTQSRQAPLAFQAGGRRG------------DFIYV 253
F P S + P W + G++ F T + F G R DF +
Sbjct: 484 FETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAI 543
Query: 254 DIFEGHLRAVVEKGQGTVLLHNSV-PVADGQPHEVSVHINAHRLEISVDQYPTHTSNRGV 312
++ +GHL +++ G GT+ + + V DG+ + V + ISV+ T + G
Sbjct: 544 EMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGE 603
Query: 313 LSYLEPRGSLLLGGLDAEASRHLQEHRLGLT------PEATNASLLGCMEDLSVNGQRRG 366
L+ L LGG L E++ GL N +GC+ DL ++GQ +
Sbjct: 604 SEILDLDDELYLGG--------LPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKD 655
Query: 367 LRE 369
+R+
Sbjct: 656 IRQ 658
Score = 48.1 bits (113), Expect = 1e-04
Identities = 90/391 (23%), Positives = 154/391 (39%), Gaps = 37/391 (9%)
Query: 25 RLASAASFFGENHLEV--PVATALTDIDLQLQFSTSQPEALLLLAAG--PADHLLLQLYS 80
R A+ S+ G +++ PV D+ L+F + + +L+ AD L L+L +
Sbjct: 714 REATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDA 773
Query: 81 GRLQVRLVLGQEELRLQTPA----ETL-----LSDSIPHTVVLTVVEGWATLSVDGFLNA 131
GR V+L + + +R+ + ETL L+D+ HTV + L+VD
Sbjct: 774 GR--VKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAM 831
Query: 132 SSAVPGAPLEVPYGLFVGGTGTLGLPYLRGTSRPLRGCLHAATLNGRSLLRPLTPDVHEG 191
+ + G + + G T YL G L + T NG + + +
Sbjct: 832 TGQMAGDHTRLEFHNIETGIIT-ERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDY 890
Query: 192 CA--EEFSASDDVA--LGFSGPHSLAAFPAWGTQDEGTLEFTLTTQSRQAPLAFQAGGRR 247
C F + +A + F S A L F T S + + +G
Sbjct: 891 CELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGN 950
Query: 248 GDFIYVDIFEGHLRAVVEKGQGTVLLHNS--VPVADGQPHEVSVHINAHRLE-ISVDQYP 304
DFI V++ +G+L V + G G L+ S P+ D Q H V + + L + +D
Sbjct: 951 -DFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKI 1009
Query: 305 THTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLTPEATNA--SLLGCMEDLSVNG 362
T G + L+ + L +GG+ E + L P+ +A GC+ + +NG
Sbjct: 1010 TTQITAGARN-LDLKSDLYIGGVAKETYKSL--------PKLVHAKEGFQGCLASVDLNG 1060
Query: 363 QRRGLREALLTRN--MAAGCRLEEEEYEDDA 391
+ L L N + GC ++D+
Sbjct: 1061 RLPDLISDALFCNGQIERGCEGPSTTCQEDS 1091
>gi|208609951 neurexin 1 isoform alpha2 precursor [Homo sapiens]
Length = 1547
Score = 67.4 bits (163), Expect = 2e-10
Identities = 85/370 (22%), Positives = 137/370 (37%), Gaps = 61/370 (16%)
Query: 50 DLQLQFSTSQPEALLLLAAGPADHLLLQLYSGRLQVRLVLGQEELR-LQTPAETLLSDSI 108
++ L F T Q L+L AD++ L L +G + + + LG L P +D+
Sbjct: 340 EITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNA 399
Query: 109 PHTVVLT---------------VVEGWATLSVDGFLNASSAVPG--APLEVPYGLFVGGT 151
H V +T + T+SVDG L + L +VGG+
Sbjct: 400 WHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGS 459
Query: 152 -GTLGLPYLRGTSRPLRGCLHAATLNGRSLLRPLTPDVHEGC------------AEEFSA 198
T LP S GCL + L+ +G E +
Sbjct: 460 PSTADLPG-SPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVAT 518
Query: 199 SDDVALGFSGPHSLAAFPAWGTQDEGTLEFTLTTQSRQAPLAFQAGGRRG---------- 248
D + F P S + P W + G++ F T + F G R
Sbjct: 519 LDPIT--FETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMI 576
Query: 249 --DFIYVDIFEGHLRAVVEKGQGTVLLHNSV-PVADGQPHEVSVHINAHRLEISVDQYPT 305
DF +++ +GHL +++ G GT+ + + V DG+ + V + ISV+ T
Sbjct: 577 KVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRT 636
Query: 306 HTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLT------PEATNASLLGCMEDLS 359
+ G L+ L LGG L E++ GL N +GC+ DL
Sbjct: 637 PYTAPGESEILDLDDELYLGG--------LPENKAGLVFPTEVWTALLNYGYVGCIRDLF 688
Query: 360 VNGQRRGLRE 369
++GQ + +R+
Sbjct: 689 IDGQSKDIRQ 698
Score = 48.1 bits (113), Expect = 1e-04
Identities = 90/391 (23%), Positives = 154/391 (39%), Gaps = 37/391 (9%)
Query: 25 RLASAASFFGENHLEV--PVATALTDIDLQLQFSTSQPEALLLLAAG--PADHLLLQLYS 80
R A+ S+ G +++ PV D+ L+F + + +L+ AD L L+L +
Sbjct: 754 REATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDA 813
Query: 81 GRLQVRLVLGQEELRLQTPA----ETL-----LSDSIPHTVVLTVVEGWATLSVDGFLNA 131
GR V+L + + +R+ + ETL L+D+ HTV + L+VD
Sbjct: 814 GR--VKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAM 871
Query: 132 SSAVPGAPLEVPYGLFVGGTGTLGLPYLRGTSRPLRGCLHAATLNGRSLLRPLTPDVHEG 191
+ + G + + G T YL G L + T NG + + +
Sbjct: 872 TGQMAGDHTRLEFHNIETGIIT-ERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDY 930
Query: 192 CA--EEFSASDDVA--LGFSGPHSLAAFPAWGTQDEGTLEFTLTTQSRQAPLAFQAGGRR 247
C F + +A + F S A L F T S + + +G
Sbjct: 931 CELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGN 990
Query: 248 GDFIYVDIFEGHLRAVVEKGQGTVLLHNS--VPVADGQPHEVSVHINAHRLE-ISVDQYP 304
DFI V++ +G+L V + G G L+ S P+ D Q H V + + L + +D
Sbjct: 991 -DFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKI 1049
Query: 305 THTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLTPEATNA--SLLGCMEDLSVNG 362
T G + L+ + L +GG+ E + L P+ +A GC+ + +NG
Sbjct: 1050 TTQITAGARN-LDLKSDLYIGGVAKETYKSL--------PKLVHAKEGFQGCLASVDLNG 1100
Query: 363 QRRGLREALLTRN--MAAGCRLEEEEYEDDA 391
+ L L N + GC ++D+
Sbjct: 1101 RLPDLISDALFCNGQIERGCEGPSTTCQEDS 1131
>gi|21070969 neurexin 3 isoform 1 precursor [Homo sapiens]
Length = 1061
Score = 60.5 bits (145), Expect = 2e-08
Identities = 46/193 (23%), Positives = 82/193 (42%), Gaps = 27/193 (13%)
Query: 204 LGFSGPHSLAAFPAWGTQDEGTLEFTLTTQSRQAPLAFQAG------------GRRGDFI 251
+ F P + + P W T+ G++ F T + F G + DF
Sbjct: 76 INFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFF 135
Query: 252 YVDIFEGHLRAVVEKGQGTVLLHNSVPVA-DGQPHEVSVHINAHRLEISVDQYPTHTSNR 310
V++ +G+L +++ G GT+ + + A DG+ + V + + ISV+ T +
Sbjct: 136 AVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFTAS 195
Query: 311 GVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLT------PEATNASLLGCMEDLSVNGQR 364
G L+ G + LGG L E+R GL N +GC+ DL ++G+
Sbjct: 196 GESEILDLEGDMYLGG--------LPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRS 247
Query: 365 RGLREALLTRNMA 377
+ +R+ +N A
Sbjct: 248 KNIRQLAEMQNAA 260
Score = 50.1 bits (118), Expect = 3e-05
Identities = 78/347 (22%), Positives = 138/347 (39%), Gaps = 56/347 (16%)
Query: 36 NHLEVPVATALTDIDLQLQFSTSQPEALLLLAAGPA-DHLLLQLYSGRLQVRLVLGQEEL 94
++L + A T + L QF T+ P+ +L +G D + ++L G + LG
Sbjct: 507 SYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPN 566
Query: 95 RLQTPAETLLSDSIPHTVVLTVVEGWA-TLSVDGFLNASSAVPGAP-LEVPYGLFVGGTG 152
++ ++ L+D+ H VV+T +L VD + + + GA L++ L++ G
Sbjct: 567 VIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDTKV-VTQVINGAKNLDLKGDLYMAGLA 625
Query: 153 T---LGLPYLRGTSRPLRGCLHAATLNGRSLLRPLTPDVHEG-------------CAEEF 196
LP L + +GCL + LNGR L + +H C E+
Sbjct: 626 QGMYSNLPKLVASRDGFQGCLASVDLNGR-LPDLINDALHRSGQIERGCEGPSTTCQEDS 684
Query: 197 SASDDVAL----GFSGPHSLAAFPAWGTQDEGT----------LEFTL------TTQSRQ 236
A+ V + GF+ S+ ++ D G + +T +T+S +
Sbjct: 685 CANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPANDRPSTRSDR 744
Query: 237 APLAFQAGGRRGDFIYVDIFEG---HLRAVVEKGQ-------GTV---LLHNSVPVADGQ 283
+ F + G + +D G L+ +E+G+ GTV + PV DG+
Sbjct: 745 LAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGK 804
Query: 284 PHEVSVHINAHRLEISVDQYPT--HTSNRGVLSYLEPRGSLLLGGLD 328
H V N + VD +P H L+ + + +GG D
Sbjct: 805 YHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKD 851
Score = 36.6 bits (83), Expect = 0.29
Identities = 45/188 (23%), Positives = 80/188 (42%), Gaps = 20/188 (10%)
Query: 211 SLAAFPAWGTQDEGTLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQGT 270
SLA A+ + L F T S + F +G DFI V++ +G++ V + G G
Sbjct: 510 SLATLQAYTSMH---LFFQFKTTSPDGFILFNSGDGN-DFIAVELVKGYIHYVFDLGNGP 565
Query: 271 VLL--HNSVPVADGQPHEVSV---HINAHRLEISVDQYPTHTSNRGVLSYLEPRGSLLLG 325
++ ++ P+ D Q H V + + N H L++ + T N L+ +G L +
Sbjct: 566 NVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDT-KVVTQVINGA--KNLDLKGDLYMA 622
Query: 326 GLDAEASRHLQEHRLGLTPEATNASLLGCMEDLSVNGQRRGLREALLTRN--MAAGCRLE 383
GL +L + A+ GC+ + +NG+ L L R+ + GC
Sbjct: 623 GLAQGMYSNLPK------LVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGP 676
Query: 384 EEEYEDDA 391
++D+
Sbjct: 677 STTCQEDS 684
>gi|54873613 agrin [Homo sapiens]
Length = 2045
Score = 51.6 bits (122), Expect = 9e-06
Identities = 95/413 (23%), Positives = 144/413 (34%), Gaps = 70/413 (16%)
Query: 30 ASFFGENHLEVP-VATALTDID----LQLQFSTSQPEALLLLAA----GPADHLLLQLYS 80
A F G +HLE+ + T D+ L++ F P LLL G D + L L
Sbjct: 1638 ADFNGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRD 1697
Query: 81 GRLQVRLVLGQEELRLQTPAETLLSDSIPHTVVLTVVEGWATLSVDGFLNASSAVPGAPL 140
RL+ R LG+ +++ L ++ +G + + S VP L
Sbjct: 1698 RRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPVPHTVL 1757
Query: 141 EVPYGLFVGGTGTLG-LPYLRGTSRPLRGCLHAATLNGRSLL----------------RP 183
+ L+VGG L S G + +L GR LL P
Sbjct: 1758 NLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHP 1817
Query: 184 LTPDVHEGCAEEFSASDDVAL-------GFSGPHSLAAFPAWGTQDEGTLEF-------- 228
T C S A GFSGPH D TL F
Sbjct: 1818 CTRASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEY 1877
Query: 229 ------------------TLTTQSRQAPLAFQAGG-RRGDFIYVDIFEGHLRAVVEKGQG 269
+L T++ Q + + R D++ + I +GHL+ G
Sbjct: 1878 LNAVTESEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQ 1937
Query: 270 TVLLHNSVPVADGQPHEVSVHINAHRLEISV-DQYPTHTSNRGVLSYLEPRGSLLLGGLD 328
V+L ++VPV + V H + V ++ P S+ + L+ G+L LGG
Sbjct: 1938 PVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGG-- 1995
Query: 329 AEASRHLQEHRLG-LTPEATNASLLGCMEDLSVNGQRRGLREALLTRNMAAGC 380
L E +G P+A +GC+ D+ V L E +T+ C
Sbjct: 1996 ------LPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRPC 2042
Score = 47.8 bits (112), Expect = 1e-04
Identities = 43/172 (25%), Positives = 67/172 (38%), Gaps = 9/172 (5%)
Query: 211 SLAAFPAWGTQDEGTLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQGT 270
S AFP L Q L + R DF+ + + +G ++ + G G
Sbjct: 1381 SFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSGP 1440
Query: 271 VLLHNSVPVADGQPHEVSVHINAHRLEISVD-QYPTHTSNRGVLSYLEPRGSLLLGGLDA 329
+L ++VPV GQ H + + + R +SVD + P + L L +GG+
Sbjct: 1441 AVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPE 1500
Query: 330 EASRHLQEHRLGLTPEATNASLLGCMEDLSVNGQR--RGLREALLTRNMAAG 379
+ + + L A L GC+ L VN QR G+ TR G
Sbjct: 1501 D------QAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGVG 1546
Score = 40.8 bits (94), Expect = 0.016
Identities = 48/167 (28%), Positives = 66/167 (39%), Gaps = 21/167 (12%)
Query: 27 ASAASFFGENHLEVPVATALTDIDLQLQFSTSQPEALLLL--AAGPADHLLLQLYSGRLQ 84
A +F G + L P A + L L+F +P+ LLL A D L L L GR+Q
Sbjct: 1372 APVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQ 1431
Query: 85 VRLVLGQEELRLQTPAETLLSDSIP------HTVVLTVVEGWATLSVDGFLNASSAVPGA 138
+R G +L+ ++P H + L+ TLSVDG P
Sbjct: 1432 LRFDTGS--------GPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSG 1483
Query: 139 P--LEVPYGLFVGGT-GTLGLPYLRGT--SRPLRGCLHAATLNGRSL 180
L + LFVGG L T LRGC+ +N + L
Sbjct: 1484 TDGLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLLDVNNQRL 1530
>gi|116284404 cell recognition protein CASPR4 isoform 1 [Homo
sapiens]
Length = 1308
Score = 50.8 bits (120), Expect = 2e-05
Identities = 70/330 (21%), Positives = 129/330 (39%), Gaps = 30/330 (9%)
Query: 51 LQLQFSTSQPEALLLLAAGP-ADHLLLQLYSGRLQVRLVLGQEELR-----LQTPAETLL 104
+ L+F T Q + +LL GP DH+ LQL RL + + G+ +L + +LL
Sbjct: 208 ISLKFKTMQSDGILLHREGPNGDHITLQLRRARLFLLINSGEAKLPSTSTLVNLTLGSLL 267
Query: 105 SDSIPHTVVLTVVEGWATLSVDGFLNASSA-----VPGAPLEVPYGLFVGGTGTLGLPYL 159
D H+V++ + +VD + A + E+ +G ++ P+
Sbjct: 268 DDQHWHSVLIQRLGKQVNFTVDEHRHHFHARGEFNLMNLDYEISFGGIPAPGKSVSFPH- 326
Query: 160 RGTSRPLRGCLHAATLNGRSLL---RPLTPDVHEGCAEEFSASD--DVALGFSGPHSLAA 214
R GCL NG ++ + P + FS S + + F S A
Sbjct: 327 ----RNFHGCLENLYYNGVDIIDLAKQQKPQIIAMGNVSFSCSQPQSMPVTFLSSRSYLA 382
Query: 215 FPAWGTQDEGTLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRA-VVEKGQGTVLL 273
P + ++E + F T ++ L F I + + +G L++ + + G+ +
Sbjct: 383 LPDFSGEEEVSATFQFRTWNKAGLLLFSELQLISGGILLFLSDGKLKSNLYQPGKLPSDI 442
Query: 274 HNSVPVADGQPHEVSVHINAHRLEISVDQYPTHTSNRGVLSYLEPRGSLLLGGLDAEASR 333
V + DGQ H VS+ + L ++VD + + G+ GG
Sbjct: 443 TAGVELNDGQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGG------- 495
Query: 334 HLQEHRLGLTPEATNASLLGCMEDLSVNGQ 363
+ G ++ GCM +S++G+
Sbjct: 496 -CPDKSFGSKCKSPLGGFQGCMRLISISGK 524
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 50.1 bits (118), Expect = 3e-05
Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 11/148 (7%)
Query: 220 TQDEGTLEFTLTTQSRQ-APLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLH-NSV 277
T++E LE LT + R + A R D+ ++I G L+ + G G ++ S+
Sbjct: 3845 TENENKLEMKLTMRLRTYSTHAVVMYARGTDYSILEIHHGRLQYKFDCGSGPGIVSVQSI 3904
Query: 278 PVADGQPHEVSVHINAHRLEISVDQYPTHTSNR-GVLSYLEPRGSLLLGG-LDAEASRHL 335
V DGQ H V++ +N + + +DQ T + G L L + GG + + +RH
Sbjct: 3905 QVNDGQWHAVALEVNGNYARLVLDQVHTASGTAPGTLKTLNLDNYVFFGGHIRQQGTRH- 3963
Query: 336 QEHRLGLTPEATNASLLGCMEDLSVNGQ 363
G +P+ N GCM+ + +NGQ
Sbjct: 3964 -----GRSPQVGN-GFRGCMDSIYLNGQ 3985
Score = 40.0 bits (92), Expect = 0.027
Identities = 45/171 (26%), Positives = 73/171 (42%), Gaps = 19/171 (11%)
Query: 48 DIDLQLQFSTSQPEALLLLAAGPADHLLLQLYSGRLQVRLVLGQEELRLQTPAETLLSDS 107
++ L ++ T A+++ A G D+ +L+++ GRLQ + G + + ++D
Sbjct: 3852 EMKLTMRLRTYSTHAVVMYARG-TDYSILEIHHGRLQYKFDCGSGP-GIVSVQSIQVNDG 3909
Query: 108 IPHTVVLTVVEGWATLSVDGFLNASSAVPGA--PLEVPYGLFVGG-TGTLGLPYLRG--T 162
H V L V +A L +D AS PG L + +F GG G + R
Sbjct: 3910 QWHAVALEVNGNYARLVLDQVHTASGTAPGTLKTLNLDNYVFFGGHIRQQGTRHGRSPQV 3969
Query: 163 SRPLRGCLHAATLNGRSLLRPLTP----------DVHEGCAEEFSASDDVA 203
RGC+ + LNG+ L P DV GC +A++D A
Sbjct: 3970 GNGFRGCMDSIYLNGQELPLNSKPRSYAHIEESVDVSPGCF--LTATEDCA 4018
>gi|18640734 contactin associated protein-like 5 [Homo sapiens]
Length = 1306
Score = 49.3 bits (116), Expect = 4e-05
Identities = 65/273 (23%), Positives = 116/273 (42%), Gaps = 19/273 (6%)
Query: 44 TALTDIDLQLQFSTSQPEALLLLAAGP-ADHLLLQLYSGRLQVRLVLGQEELRLQT--PA 100
+ L D+ + L+F + Q + +L G DH+ L+L GRL + L LG + RL + P+
Sbjct: 199 STLKDV-ISLKFKSMQGDGVLFHGEGQRGDHITLELQKGRLALHLNLGDSKARLSSSLPS 257
Query: 101 ET---LLSDSIPHTVVLTVVEGWATLSVDGFL-NASSAVPGAPLEVPYGLFVGGTGTLGL 156
T LL D H+V++ V +VD + + L++ Y L GG G
Sbjct: 258 ATLGSLLDDQHWHSVLIERVGKQVNFTVDKHTQHFRTKGETDALDIDYELSFGGIPVPGK 317
Query: 157 PYLRGT--SRPLRGCLHAATLNGRSLLRPLTPDVHEGCAEE--FSASDDVALGFSGPHSL 212
P GT + GC+ NG +++ H+ FS S+ + + +S
Sbjct: 318 P---GTFLKKNFHGCIENLYYNGVNIIDLAKRRKHQIYTGNVTFSCSEPQIVPITFVNSS 374
Query: 213 AAF---PAWGTQDEGTLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQG 269
++ P D ++ F T ++ L + + + G LR V++K
Sbjct: 375 GSYLLLPGTPQIDGLSVSFQFRTWNKDGLLLSTELSEGSGTLLLSLEGGILRLVIQKMTE 434
Query: 270 TVL-LHNSVPVADGQPHEVSVHINAHRLEISVD 301
V + + DG H VS++ +R+ +++D
Sbjct: 435 RVAEILTGSNLNDGLWHSVSINARRNRITLTLD 467
Score = 38.1 bits (87), Expect = 0.10
Identities = 31/129 (24%), Positives = 51/129 (39%), Gaps = 17/129 (13%)
Query: 241 FQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLHNSVPVA-------DGQPHEVSVHINA 293
F G+RGD I +++ +G L + G L +S+P A D H V +
Sbjct: 219 FHGEGQRGDHITLELQKGRLALHLNLGDSKARLSSSLPSATLGSLLDDQHWHSVLIERVG 278
Query: 294 HRLEISVDQYPTHTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLTPEATNASLLG 353
++ +VD++ H +G L+ L GG+ G + G
Sbjct: 279 KQVNFTVDKHTQHFRTKGETDALDIDYELSFGGIPVP----------GKPGTFLKKNFHG 328
Query: 354 CMEDLSVNG 362
C+E+L NG
Sbjct: 329 CIENLYYNG 337
Score = 37.4 bits (85), Expect = 0.17
Identities = 43/184 (23%), Positives = 65/184 (35%), Gaps = 25/184 (13%)
Query: 203 ALGFSGPHSLAAFPAWGTQDEGTLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFE-GHLR 261
A+ F S FP + + + F T + G + DFI ++I +
Sbjct: 792 AVSFYTEASYLHFPTFHAEFSADISFFFKTTALSGVFLENLGIK--DFIRLEISSPSEIT 849
Query: 262 AVVEKGQGTVLLHNSVP--VADGQPHEVSVHINAHRLEISVDQYPTHTSNRGVLSY--LE 317
++ G G V L P + D Q H V N + VD P T + L+
Sbjct: 850 FAIDVGNGPVELVVQSPSLLNDNQWHYVRAERNLKETSLQVDNLPRSTRETSEEGHFRLQ 909
Query: 318 PRGSLLLGGLDAEASRHLQEHRLGLTPEATNASLLGCMEDLSVNGQRRGLRE-ALLTRNM 376
L +GG + LGC+ L +NGQ+ L E A +T +
Sbjct: 910 LNSQLFVGGTSSRQK-----------------GFLGCIRSLHLNGQKMDLEERAKVTSGV 952
Query: 377 AAGC 380
GC
Sbjct: 953 RPGC 956
>gi|38788416 laminin, alpha 1 precursor [Homo sapiens]
Length = 3075
Score = 48.5 bits (114), Expect = 7e-05
Identities = 82/333 (24%), Positives = 145/333 (43%), Gaps = 32/333 (9%)
Query: 51 LQLQFSTSQPEALL--LLAAGPADHLLLQLYSGRLQVRLVLGQEELRLQTPAETLLSDSI 108
L L T +P+ LL L ++ +D L +++ GR+ LG RL+ P + + D+
Sbjct: 2142 LTLNVKTQEPDNLLFYLGSSTASDFLAVEMRRGRVAFLWDLGSGSTRLEFP-DFPIDDNR 2200
Query: 109 PHTVVLTVVEGWATLSVDGFLN------ASSAVPGAP--LEVPYG--LFVGGTG--TLGL 156
H++ + +LSV + +S PG L+V +FVGG G
Sbjct: 2201 WHSIHVARFGNIGSLSVKEMSSNQKSPTKTSKSPGTANVLDVNNSTLMFVGGLGGQIKKS 2260
Query: 157 PYLRGTSRPLRGCLHAATLNGRSLLRPLTPDVHEGCAEEFSAS--DDVALGFSGP-HSLA 213
P ++ T +GCL A LNG+S+ + C F +S +D + F G +S+
Sbjct: 2261 PAVKVTH--FKGCLGEAFLNGKSIGLWNYIEREGKCRGCFGSSQNEDPSFHFDGSGYSVV 2318
Query: 214 --AFPAWGTQDEGTLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQGTV 271
+ PA TQ + T S L + DF+ +++F G ++ + + G G +
Sbjct: 2319 EKSLPATVTQ----IIMLFNTFSPNGLLLYLGSYGTKDFLSIELFRGRVKVMTDLGSGPI 2374
Query: 272 LLHNSVPVADGQPHEVSVHINAHRLEISV-DQYPTHTSNRGVLSYLEPRGSLLLGGLDAE 330
L +G ++++ N + ++V D Y +TSN+ P S L LD +
Sbjct: 2375 TLLTDRRYNNGTWYKIAFQRNRKQGVLAVIDAY--NTSNKETKQGETPGASSDLNRLDKD 2432
Query: 331 A--SRHLQEHRLGLTPEATNASLLGCMEDLSVN 361
L R+ + T S +GC+++L ++
Sbjct: 2433 PIYVGGLPRSRV-VRRGVTTKSFVGCIKNLEIS 2464
Score = 48.1 bits (113), Expect = 1e-04
Identities = 105/422 (24%), Positives = 160/422 (37%), Gaps = 76/422 (18%)
Query: 32 FFGENHLEVPVATALTDIDLQLQFSTSQPEALLLLAA--GPADHLLLQLYSGRLQVRLVL 89
F G + V + T + + F+T P LLL G D L ++L+ GR++V L
Sbjct: 2310 FDGSGYSVVEKSLPATVTQIIMLFNTFSPNGLLLYLGSYGTKDFLSIELFRGRVKVMTDL 2369
Query: 90 GQEELRLQTPAE-------TLLSDSIPHTVVLTVVEGWATLSVDGFLNASSAVPGAPLEV 142
G + L T + VL V++ + T + + PGA ++
Sbjct: 2370 GSGPITLLTDRRYNNGTWYKIAFQRNRKQGVLAVIDAYNTSNKE---TKQGETPGASSDL 2426
Query: 143 PY----GLFVGGTGTLGLPYLRGTSRPLRGCLHAATLNGRS--LLRPLTPDVHEGCAEEF 196
++VGG + T++ GC+ ++ + LLR + V +GC E
Sbjct: 2427 NRLDKDPIYVGGLPRSRVVRRGVTTKSFVGCIKNLEISRSTFDLLRN-SYGVRKGCLLEP 2485
Query: 197 SASDDVALGFS---GPHSLAAFPAWGTQDEGTLEFTLTTQSRQAPLAFQAGG--RRGD-- 249
S G P SL+ W L TT S LA G +RGD
Sbjct: 2486 IRSVSFLKGGYIELPPKSLSPESEW-------LVTFATTNSSGIILAALGGDVEKRGDRE 2538
Query: 250 -----FIYVDIFEGHLRAVVEKGQGT----VLLHNSVPV-ADGQPHEVSVHINAHRLEIS 299
F V + G++ V G GT LLH +DGQ H +S+ N + +
Sbjct: 2539 EAHVPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAPTGTCSDGQAHSISLVRNRRIITVQ 2598
Query: 300 VDQYPTHTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLTPEATNASLL------- 352
+D+ N V + LG L + ++ +G PE SLL
Sbjct: 2599 LDE------NNPV--------EMKLGTLVESRTINVSNLYVGGIPEGEGTSLLTMRRSFH 2644
Query: 353 GCMEDLSVNGQRRGLREALLTRNMAAGCRLEEEEYEDDAYGHYEAFSTLAPEAWPAMELP 412
GC+++L N + LL N A G E+ + D E LAP+A + LP
Sbjct: 2645 GCIKNLIFNLE-------LLDFNSAVG----HEQVDLDTCWLSER-PKLAPDAEDSKLLP 2692
Query: 413 EP 414
EP
Sbjct: 2693 EP 2694
Score = 47.4 bits (111), Expect = 2e-04
Identities = 65/272 (23%), Positives = 112/272 (41%), Gaps = 33/272 (12%)
Query: 49 IDLQLQFSTSQPEALLLLAA--GPADHLLLQLYSGRLQVRLVLGQEELRLQTPAETLLSD 106
+ ++L T L+ A AD+ +LQL+ GRL LG+ ++ PA LLSD
Sbjct: 2737 LSVELSIRTFASSGLIYYMAHQNQADYAVLQLHGGRLHFMFDLGKGRTKVSHPA--LLSD 2794
Query: 107 SIPHTVVLTVVEGWATLSVDGFLNASSAV--PGAPLEVPYGLFVGGTGTLGLP------Y 158
HTV V+ ++VDG + V G L+V GLF G GLP
Sbjct: 2795 GKWHTVKTDYVKRKGFITVDGRESPMVTVVGDGTMLDVE-GLFYLG----GLPSQYQARK 2849
Query: 159 LRGTSRPLRGCLHAATLNGRSLLRPLTPDVHEGCAEEFSASDDVALGFSGPH----SLAA 214
+ + + C+ T+N + L + + F+ + A+ G + AA
Sbjct: 2850 IGNITHSIPACIGDVTVNSKQLDK-------DSPVSAFTVNRCYAVAQEGTYFDGSGYAA 2902
Query: 215 FPAWGTQDEGTLEFTLTTQ-SRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLL 273
G + + + TL + S Q + + D I +++ +G + V G G +
Sbjct: 2903 LVKEGYKVQSDVNITLEFRTSSQNGVLLGISTAKVDAIGLELVDGKVLFHVNNGAGRITA 2962
Query: 274 ----HNSVPVADGQPHEVSVHINAHRLEISVD 301
+ + DG+ H + + + HR+ + VD
Sbjct: 2963 AYEPKTATVLCDGKWHTLQANKSKHRITLIVD 2994
Score = 39.3 bits (90), Expect = 0.045
Identities = 48/216 (22%), Positives = 84/216 (38%), Gaps = 23/216 (10%)
Query: 193 AEEFSASDDVALGFSGPHSLAAFPAWGTQDEGTLEFTLTTQSRQAPLAFQAGGRRGDFIY 252
A + +AS VA+ A P + + TL + TQ L + DF+
Sbjct: 2109 ARKQAASIKVAVSADRDCIRAYQPQISSTNYNTLTLNVKTQEPDNLLFYLGSSTASDFLA 2168
Query: 253 VDIFEGHLRAVVEKGQGTVLLH-NSVPVADGQPHEVSVHINAHRLEISVDQY------PT 305
V++ G + + + G G+ L P+ D + H + V + +SV + PT
Sbjct: 2169 VEMRRGRVAFLWDLGSGSTRLEFPDFPIDDNRWHSIHVARFGNIGSLSVKEMSSNQKSPT 2228
Query: 306 HTS-NRGVLSYLEPRGSLLL--GGLDAEASRHLQEHRLGLTPEATNASLLGCMEDLSVNG 362
TS + G + L+ S L+ GGL + + +P GC+ + +NG
Sbjct: 2229 KTSKSPGTANVLDVNNSTLMFVGGLGGQIKK---------SPAVKVTHFKGCLGEAFLNG 2279
Query: 363 QRRGLREALLTRNMAAGC----RLEEEEYEDDAYGH 394
+ GL + GC + E+ + D G+
Sbjct: 2280 KSIGLWNYIEREGKCRGCFGSSQNEDPSFHFDGSGY 2315
Score = 34.7 bits (78), Expect = 1.1
Identities = 31/156 (19%), Positives = 69/156 (44%), Gaps = 9/156 (5%)
Query: 210 HSLAAFPAWGTQDEGTLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQG 269
H + F + + ++E ++ T + + + A + D+ + + G L + + G+G
Sbjct: 2723 HFILPFNQSAVRKKLSVELSIRTFASSGLIYYMAHQNQADYAVLQLHGGRLHFMFDLGKG 2782
Query: 270 TVLLHNSVPVADGQPHEVSVHINAHRLEISVD-QYPTHTSNRGVLSYLEPRGSLLLGGLD 328
+ + ++DG+ H V + I+VD + + G + L+ G LGGL
Sbjct: 2783 RTKVSHPALLSDGKWHTVKTDYVKRKGFITVDGRESPMVTVVGDGTMLDVEGLFYLGGLP 2842
Query: 329 AEASRHLQEHRLGLTPEATNASLLGCMEDLSVNGQR 364
++ Q ++G S+ C+ D++VN ++
Sbjct: 2843 SQ----YQARKIG----NITHSIPACIGDVTVNSKQ 2870
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 46.6 bits (109), Expect = 3e-04
Identities = 54/173 (31%), Positives = 77/173 (44%), Gaps = 18/173 (10%)
Query: 207 SGPHSLAAFPAW-GTQDEGTLEFTLTTQSRQAPLAFQAGGRRG---DFIYVDIFEGHLRA 262
SG S A PA T E L+ + L F +GG+ G DF+ + + GHL
Sbjct: 3933 SGAGSYLALPALTNTHHELRLDVEFKPLAPDGVLLF-SGGKSGPVEDFVSLAMVGGHLEF 3991
Query: 263 VVEKGQGTVLLHNSVPVADGQPHEVSVHINAHRLEISVD-QYPTHTSNRGVLSYLEPRGS 321
E G G +L ++ P+A G+ H VS + V+ P S+ G L
Sbjct: 3992 RYELGSGLAVLRSAEPLALGRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTL 4051
Query: 322 LLLGGLDAEASRHLQEHRLGLTPEATN--ASLLGCMEDLSVNGQRRGLREALL 372
L LGG+ E + L+P ATN A GC+ ++SVNG+R L + L
Sbjct: 4052 LYLGGV---------EPSVPLSP-ATNMSAHFRGCVGEVSVNGKRLDLTYSFL 4094
Score = 43.9 bits (102), Expect = 0.002
Identities = 54/225 (24%), Positives = 88/225 (39%), Gaps = 37/225 (16%)
Query: 169 CLHAATLNG-RSLLRP--LTPDVHEGCAEEFSASDDVALGFSGPHSLAAFPAWGTQDEG- 224
CLH T G R L P P +G + SD G G + + A+ D+G
Sbjct: 4153 CLHGGTCQGTRCLCLPGFSGPRCQQGSGHGIAESDWHLEGSGGNDAPGQYGAY-FHDDGF 4211
Query: 225 -----------------TLEFTLTTQSRQAPLAFQA-----GGRRGDFIYVDIFEGHLRA 262
T+E + T + L +Q G+ DFI + + +GHL
Sbjct: 4212 LAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVF 4271
Query: 263 VVEKGQGTVLLHNSVPVADGQPHEVSVHINAHRLEISVD-QYPTHTSNRGVLSYLEPRGS 321
+ G G L + P+ DG+ H V+ R I VD + + G + +GS
Sbjct: 4272 RYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQVDGEELVSGRSPGPNVAVNAKGS 4331
Query: 322 LLLGGLDAEASRHLQEHRLGLTPEATNASLLGCMEDLSVNGQRRG 366
+ +GG A+ LT ++ + GC+++L ++ R G
Sbjct: 4332 VYIGGAPDVAT---------LTGGRFSSGITGCVKNLVLHSARPG 4367
Score = 35.0 bits (79), Expect = 0.86
Identities = 31/137 (22%), Positives = 58/137 (42%), Gaps = 12/137 (8%)
Query: 246 RRGDFIYVDIFEGHLRAVVEKGQGTVLLHNSVPVADGQPHEVSVHINAHRLEISV-DQYP 304
R+ DFI + G + G G + + P+A G H V++ + + + V D P
Sbjct: 3719 RQPDFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAP 3778
Query: 305 THTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLTPEA-TNASLLGCMEDLSVNGQ 363
+ +++G L+ L LGG G P+A ++ +GC+ +L + G+
Sbjct: 3779 VNGTSQGKFQGLDLNEELYLGGYP----------DYGAIPKAGLSSGFIGCVRELRIQGE 3828
Query: 364 RRGLREALLTRNMAAGC 380
+ LT + + C
Sbjct: 3829 EIVFHDLNLTAHGISHC 3845
>gi|4505463 contactin associated protein 1 precursor [Homo sapiens]
Length = 1384
Score = 45.4 bits (106), Expect = 6e-04
Identities = 75/339 (22%), Positives = 122/339 (35%), Gaps = 31/339 (9%)
Query: 42 VATALTDIDLQLQFSTSQPEALLLLAAGP-ADHLLLQLYSGRLQVRLVLGQEELRLQTPA 100
V+ +L D+ F T + + LLL A G D++ L+L L + + LG ++ +
Sbjct: 191 VSRSLWDV-FAFSFKTEEKDGLLLHAEGAQGDYVTLELEGAHLLLHMSLGSSPIQPRPGH 249
Query: 101 ETL-----LSDSIPHTVVLTVVEGWATLSVDGFLNASSAVPGAP-LEVPYGLFVGG---T 151
T+ L+D H V + ++DG++ L + +F+GG
Sbjct: 250 TTVSAGGVLNDQHWHYVRVDRFGRDVNFTLDGYVQRFILNGDFERLNLDTEMFIGGLVGA 309
Query: 152 GTLGLPYLRGTSRPLRGCLHAATLNGRSLLRPLTPDVHEGCAEE----FSASDDVA--LG 205
L Y RGC+ N R + L H E F D V +
Sbjct: 310 ARKNLAYRHN----FRGCIENVIFN-RVNIADLAVRRHSRITFEGKVAFRCLDPVPHPIN 364
Query: 206 FSGPHSLAAFPAWGTQDEGTLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLR-AVV 264
F GPH+ P + + + F T L F G + + + EG + ++
Sbjct: 365 FGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLFSRLGDGLGHVELTLSEGQVNVSIA 424
Query: 265 EKGQGTVLLHNSVPVADGQPHEVSVHINAHRLEISVDQYPTHTSNRGVLSYLEPRGSLLL 324
+ G+ + + DG HEV+ + IS+D + S
Sbjct: 425 QSGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFF 484
Query: 325 GGLDAEASRHLQEHRLGLTPEATNASLLGCMEDLSVNGQ 363
GG ASR + + GCME L V+GQ
Sbjct: 485 GGCPKPASR--------WDCHSNQTAFHGCMELLKVDGQ 515
Score = 38.9 bits (89), Expect = 0.059
Identities = 35/136 (25%), Positives = 51/136 (37%), Gaps = 15/136 (11%)
Query: 205 GFSGP-HSLAAFPAWGTQDEGTLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAV 263
G+ GP + L +P G G + +F +YV F AV
Sbjct: 1051 GYHGPGYRLPDYPRPGRPVPGYRGPVYNVTGEEVSFSFSTSSAPAVLLYVSSFVRDYMAV 1110
Query: 264 VEKGQGTVLLHNSV------------PVADGQPHEVSVHINAHRLEISVDQYPTHTSNRG 311
+ K GT+ L + PV DGQPH +++ L I VD +P
Sbjct: 1111 LIKDDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSINITRVYRNLFIQVDYFPLTEQKFS 1170
Query: 312 VL--SYLEPRGSLLLG 325
+L S L+ +L LG
Sbjct: 1171 LLVDSQLDSPKALYLG 1186
>gi|33469931 EGF-like, fibronectin type III and laminin G domains
isoform 2 [Homo sapiens]
Length = 775
Score = 45.4 bits (106), Expect = 6e-04
Identities = 73/326 (22%), Positives = 118/326 (36%), Gaps = 58/326 (17%)
Query: 32 FFGENHLEV-PVATALTDIDLQLQFSTSQPEALLLLAA----GPADHLLLQLYSGRLQVR 86
FFG +++ P+ + + L+F + LLL G D + L + LQ R
Sbjct: 157 FFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFR 216
Query: 87 LVLGQEELRLQTPAETLLSDSIPHTVVL--TVVEGWATLSVDGFLNASSAVPGAPLEVPY 144
G + + ET + HTV+L + G L+ + S + +
Sbjct: 217 FNCGTGVAIIVS--ETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRT 274
Query: 145 GLFVGGT-GTLGLPYLRGTSRPLRGCLHAATLNGRSL-LRPL------------------ 184
L++GG L GT+R +GC+ + +NGR + +RP
Sbjct: 275 PLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGI 334
Query: 185 ---TPDVHEGCAEEFSASDDVAL---GFSGPH-----------------SLAAFPAWGTQ 221
+H G A + L GF G H S AA P W +
Sbjct: 335 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATP-WPLE 393
Query: 222 DEGTLEF-----TLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLHNS 276
+ L F T S L + DF+ +++ GH+ + G GT +L +
Sbjct: 394 PQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSE 453
Query: 277 VPVADGQPHEVSVHINAHRLEISVDQ 302
P+ G HE+ V A + VD+
Sbjct: 454 DPLTLGNWHELRVSRTAKNGILQVDK 479
Score = 34.3 bits (77), Expect = 1.5
Identities = 35/145 (24%), Positives = 61/145 (42%), Gaps = 9/145 (6%)
Query: 225 TLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLHNSVPVADGQP 284
TLEF + + RGDF+ + I L+ G G ++ + + G
Sbjct: 178 TLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGW 237
Query: 285 HEVSVHINAHRLEISVDQ-YPTHTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLT 343
H V ++ + + ++ P ++G S + R L LGG A ++ L +
Sbjct: 238 HTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGG--APSAYWL------VR 289
Query: 344 PEATNASLLGCMEDLSVNGQRRGLR 368
TN GC++ L+VNG+R +R
Sbjct: 290 ATGTNRGFQGCVQSLAVNGRRIDMR 314
Score = 33.9 bits (76), Expect = 1.9
Identities = 66/345 (19%), Positives = 118/345 (34%), Gaps = 48/345 (13%)
Query: 46 LTDIDLQLQFSTSQPEALLLLA--AGPADHLLLQLYSGRLQVRLVLGQEELRLQTPAETL 103
L+ ++ ++ F + +LL + G D L + L G ++ R G L++
Sbjct: 398 LSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLT 457
Query: 104 LSDSIPHTVVLTVVEGWATLSVDGFLNASSAVPGAPLEVPYGLFVGGTGTLG-LPYLRGT 162
L + V T G + + + ++ +F+GG + G
Sbjct: 458 LGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGV 517
Query: 163 SRPLRGCLHAATLNGRSLL------------RPLTPDVHEGCAEEFSASD-------DVA 203
+P G + LN R++ P V CA S D
Sbjct: 518 LKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCP 577
Query: 204 LGFSGPHSLAAF-----------PAWGTQDEGTLEFTLTTQSRQAPLAFQAGGRRG---- 248
LGF G H A ++ T D + ++ + F+ + G
Sbjct: 578 LGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLW 637
Query: 249 ----------DFIYVDIFEGHLRAVVEKGQGTVLLHNSVPVADGQPHEVSVHINAHRLEI 298
DFI + + +G L G G + + DG+ H V + +I
Sbjct: 638 RGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKI 697
Query: 299 SVDQYPTHT-SNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGL 342
+VD Y T + G++ L G+L +GG+ A +++ GL
Sbjct: 698 TVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGL 742
>gi|33469929 EGF-like, fibronectin type III and laminin G domains
isoform 1 [Homo sapiens]
Length = 1009
Score = 45.4 bits (106), Expect = 6e-04
Identities = 73/326 (22%), Positives = 118/326 (36%), Gaps = 58/326 (17%)
Query: 32 FFGENHLEV-PVATALTDIDLQLQFSTSQPEALLLLAA----GPADHLLLQLYSGRLQVR 86
FFG +++ P+ + + L+F + LLL G D + L + LQ R
Sbjct: 391 FFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFR 450
Query: 87 LVLGQEELRLQTPAETLLSDSIPHTVVL--TVVEGWATLSVDGFLNASSAVPGAPLEVPY 144
G + + ET + HTV+L + G L+ + S + +
Sbjct: 451 FNCGTGVAIIVS--ETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRT 508
Query: 145 GLFVGGT-GTLGLPYLRGTSRPLRGCLHAATLNGRSL-LRPL------------------ 184
L++GG L GT+R +GC+ + +NGR + +RP
Sbjct: 509 PLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGI 568
Query: 185 ---TPDVHEGCAEEFSASDDVAL---GFSGPH-----------------SLAAFPAWGTQ 221
+H G A + L GF G H S AA P W +
Sbjct: 569 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATP-WPLE 627
Query: 222 DEGTLEF-----TLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLHNS 276
+ L F T S L + DF+ +++ GH+ + G GT +L +
Sbjct: 628 PQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSE 687
Query: 277 VPVADGQPHEVSVHINAHRLEISVDQ 302
P+ G HE+ V A + VD+
Sbjct: 688 DPLTLGNWHELRVSRTAKNGILQVDK 713
Score = 34.3 bits (77), Expect = 1.5
Identities = 35/145 (24%), Positives = 61/145 (42%), Gaps = 9/145 (6%)
Query: 225 TLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLHNSVPVADGQP 284
TLEF + + RGDF+ + I L+ G G ++ + + G
Sbjct: 412 TLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGW 471
Query: 285 HEVSVHINAHRLEISVDQ-YPTHTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLT 343
H V ++ + + ++ P ++G S + R L LGG A ++ L +
Sbjct: 472 HTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGG--APSAYWL------VR 523
Query: 344 PEATNASLLGCMEDLSVNGQRRGLR 368
TN GC++ L+VNG+R +R
Sbjct: 524 ATGTNRGFQGCVQSLAVNGRRIDMR 548
Score = 33.9 bits (76), Expect = 1.9
Identities = 66/345 (19%), Positives = 118/345 (34%), Gaps = 48/345 (13%)
Query: 46 LTDIDLQLQFSTSQPEALLLLA--AGPADHLLLQLYSGRLQVRLVLGQEELRLQTPAETL 103
L+ ++ ++ F + +LL + G D L + L G ++ R G L++
Sbjct: 632 LSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLT 691
Query: 104 LSDSIPHTVVLTVVEGWATLSVDGFLNASSAVPGAPLEVPYGLFVGGTGTLG-LPYLRGT 162
L + V T G + + + ++ +F+GG + G
Sbjct: 692 LGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGV 751
Query: 163 SRPLRGCLHAATLNGRSLL------------RPLTPDVHEGCAEEFSASD-------DVA 203
+P G + LN R++ P V CA S D
Sbjct: 752 LKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCP 811
Query: 204 LGFSGPHSLAAF-----------PAWGTQDEGTLEFTLTTQSRQAPLAFQAGGRRG---- 248
LGF G H A ++ T D + ++ + F+ + G
Sbjct: 812 LGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLW 871
Query: 249 ----------DFIYVDIFEGHLRAVVEKGQGTVLLHNSVPVADGQPHEVSVHINAHRLEI 298
DFI + + +G L G G + + DG+ H V + +I
Sbjct: 872 RGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKI 931
Query: 299 SVDQYPTHT-SNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGL 342
+VD Y T + G++ L G+L +GG+ A +++ GL
Sbjct: 932 TVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGL 976
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 45.1 bits (105), Expect = 8e-04
Identities = 30/103 (29%), Positives = 50/103 (48%), Gaps = 2/103 (1%)
Query: 25 RLASAASFFGENHLEVPVATALTDIDLQLQFSTSQPEALLLLAAGPADHLLLQLYSGRLQ 84
+L S E++L++P A ++ LQ +T + +LL G DH+ ++LY GR++
Sbjct: 1158 KLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYK-GDKDHIAVELYRGRVR 1216
Query: 85 VRLVLGQEELRLQTPAETLLSDSIPHTVVLTVVEGWATLSVDG 127
G ET ++D H V L ++ +LSVDG
Sbjct: 1217 ASYDTGSHPASAIYSVET-INDGNFHIVELLALDQSLSLSVDG 1258
Score = 39.7 bits (91), Expect = 0.035
Identities = 39/184 (21%), Positives = 75/184 (40%), Gaps = 15/184 (8%)
Query: 202 VALGFSGPHSLAAFPAWGTQDEGTLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLR 261
V++ F S P+ + + + + T L ++ D I V+++ G +R
Sbjct: 1160 VSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYKGDK---DHIAVELYRGRVR 1216
Query: 262 AVVEKGQGTVLLHNSVP-VADGQPHEVSVHINAHRLEISVD----QYPTHTSNRGVLSYL 316
A + G SV + DG H V + L +SVD + T+ S + L++
Sbjct: 1217 ASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGNPKIITNLSKQSTLNFD 1276
Query: 317 EPRGSLLLGGLDAEASRHLQEHRLGLTPEATNASLLGCMEDLSVNGQRRGLREALLTRNM 376
P L +GG+ +++ L P S GC+ +L +N + + ++ + +
Sbjct: 1277 SP---LYVGGMPGKSN----VASLRQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGI 1329
Query: 377 AAGC 380
GC
Sbjct: 1330 LPGC 1333
>gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo
sapiens]
Length = 3118
Score = 44.7 bits (104), Expect = 0.001
Identities = 78/345 (22%), Positives = 117/345 (33%), Gaps = 70/345 (20%)
Query: 50 DLQLQFSTSQPEALLLLAAG--PAD-----------HLLLQLYSGRLQVRLVLGQEELR- 95
++ L FST ++LL +G PA + ++ L GRL+V L G +R
Sbjct: 2545 EINLSFSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYVILLNRGRLEVHLSTGARTMRK 2604
Query: 96 -LQTPAETLLSDSIPHTVVLTVVEGWATLSVDGFLN-ASSAVPGAPLEVPYGLFVGGTGT 153
+ P L D H+V + G T+ VD + P+EV LFVGG
Sbjct: 2605 IVIRPEPNLFHDGREHSVHVERTRGIFTVQVDENRRYMQNLTVEQPIEVKK-LFVGGAPP 2663
Query: 154 LGLPYLRGTSRPLRGCLHAATLN-----------------GRSLLRPLTPD--------- 187
P P GC+ +N GR + L D
Sbjct: 2664 EFQPSPLRNIPPFEGCIWNLVINSVPMDFARPVSFKNADIGRCAHQKLREDEDGAAPAEI 2723
Query: 188 -------------------VHEGCAEEFSAS---DDVALGFS-GPHSLAAFPAWGTQDEG 224
H CA E + G S H AF ++
Sbjct: 2724 VIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQFGLSRNSHIAIAFDDTKVKNRL 2783
Query: 225 TLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLHNSVP--VADG 282
T+E + T++ L + A DF V + G + G G H +P + DG
Sbjct: 2784 TIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDLGSGDT--HTMIPTKINDG 2841
Query: 283 QPHEVSVHINAHRLEISVDQYPTHTSNRGVLSYLEPRGSLLLGGL 327
Q H++ + + + VD T + L+ G L +GGL
Sbjct: 2842 QWHKIKIMRSKQEGILYVDGASNRTISPKKADILDVVGMLYVGGL 2886
Score = 36.2 bits (82), Expect = 0.38
Identities = 79/330 (23%), Positives = 127/330 (38%), Gaps = 41/330 (12%)
Query: 49 IDLQLQFSTSQPEALLLLAA--GPADHLLLQLYSGRLQVRLVLGQEELRLQTPAETLLSD 106
+ ++L+ T LL A AD +QL +G LG + P T ++D
Sbjct: 2783 LTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDLGSGDTHTMIP--TKIND 2840
Query: 107 SIPHTVVLTVVEGWATLSVDGFLNASSAVPGAP-LEVPYGLFVGGTGTLGLPYLRGTSR- 164
H + + + L VDG N + + A L+V L+VGG LP T R
Sbjct: 2841 GQWHKIKIMRSKQEGILYVDGASNRTISPKKADILDVVGMLYVGG-----LPINYTTRRI 2895
Query: 165 -----PLRGC---LHAATLNGRSLLRPLTPDVHEGCAEEFSASDDVALGFSGPHSLAAFP 216
+ GC LH A + L T H G A+ F G A
Sbjct: 2896 GPVTYSIDGCVRNLHMA--EAPADLEQPTSSFHVGTC---FANAQRGTYFDGTGFAKAVG 2950
Query: 217 AWGTQDEGTLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQG--TVLLH 274
+ + +EF T + L ++ D + +++ + L V+ G G T +
Sbjct: 2951 GFKVGLDLLVEFEFRTTTTTGVL-LGISSQKMDGMGIEMIDEKLMFHVDNGAGRFTAVYD 3009
Query: 275 NSVP--VADGQPHEVSVHINAHRLEISVD--QYPTHTSNRGVLSYLEPRGSLLLGGLDAE 330
VP + DGQ H+V+ + HR+E++VD Q + N S + + +GG +
Sbjct: 3010 AGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTS-ADTNDPVFVGGFPDD 3068
Query: 331 ASRHLQEHRLGLTPEATNASLLGCMEDLSV 360
+ GLT T+ GC+ L +
Sbjct: 3069 LK------QFGLT---TSIPFRGCIRSLKL 3089
Score = 34.3 bits (77), Expect = 1.5
Identities = 42/200 (21%), Positives = 78/200 (39%), Gaps = 11/200 (5%)
Query: 190 EGCAEEFSASD-DVALGFSGP-HSLAAFPAWGTQDEGTLEFTLTTQSRQAPLAFQAGGRR 247
+GC D + + F G ++L + P + T+ F T S A L + A
Sbjct: 2326 KGCTVSPQVEDSEGTIQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDL 2385
Query: 248 GDFIYVDIFEGHLRAVVEKGQGTVLLHNSVPVADGQPHEVSVHINAHRLEISVDQYPTHT 307
DF+ V++ +GH++ + G G + ++ DG+ ++ + IS+ T+
Sbjct: 2386 RDFMSVELTDGHIKVSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQ 2445
Query: 308 SNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRL----GLTPEATNASLLGCMEDLSVNGQ 363
+ S GLD +A + L L PE GC++D+ ++
Sbjct: 2446 EEN-----IATSSSGNNFGLDLKADDKIYFGGLPTLRNLRPEVNLKKYSGCLKDIEISRT 2500
Query: 364 RRGLREALLTRNMAAGCRLE 383
+ + + GC LE
Sbjct: 2501 PYNILSSPDYVGVTKGCSLE 2520
>gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo
sapiens]
Length = 3122
Score = 44.7 bits (104), Expect = 0.001
Identities = 78/345 (22%), Positives = 117/345 (33%), Gaps = 70/345 (20%)
Query: 50 DLQLQFSTSQPEALLLLAAG--PAD-----------HLLLQLYSGRLQVRLVLGQEELR- 95
++ L FST ++LL +G PA + ++ L GRL+V L G +R
Sbjct: 2549 EINLSFSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYVILLNRGRLEVHLSTGARTMRK 2608
Query: 96 -LQTPAETLLSDSIPHTVVLTVVEGWATLSVDGFLN-ASSAVPGAPLEVPYGLFVGGTGT 153
+ P L D H+V + G T+ VD + P+EV LFVGG
Sbjct: 2609 IVIRPEPNLFHDGREHSVHVERTRGIFTVQVDENRRYMQNLTVEQPIEVKK-LFVGGAPP 2667
Query: 154 LGLPYLRGTSRPLRGCLHAATLN-----------------GRSLLRPLTPD--------- 187
P P GC+ +N GR + L D
Sbjct: 2668 EFQPSPLRNIPPFEGCIWNLVINSVPMDFARPVSFKNADIGRCAHQKLREDEDGAAPAEI 2727
Query: 188 -------------------VHEGCAEEFSAS---DDVALGFS-GPHSLAAFPAWGTQDEG 224
H CA E + G S H AF ++
Sbjct: 2728 VIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQFGLSRNSHIAIAFDDTKVKNRL 2787
Query: 225 TLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLHNSVP--VADG 282
T+E + T++ L + A DF V + G + G G H +P + DG
Sbjct: 2788 TIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDLGSGDT--HTMIPTKINDG 2845
Query: 283 QPHEVSVHINAHRLEISVDQYPTHTSNRGVLSYLEPRGSLLLGGL 327
Q H++ + + + VD T + L+ G L +GGL
Sbjct: 2846 QWHKIKIMRSKQEGILYVDGASNRTISPKKADILDVVGMLYVGGL 2890
Score = 36.2 bits (82), Expect = 0.38
Identities = 79/330 (23%), Positives = 127/330 (38%), Gaps = 41/330 (12%)
Query: 49 IDLQLQFSTSQPEALLLLAA--GPADHLLLQLYSGRLQVRLVLGQEELRLQTPAETLLSD 106
+ ++L+ T LL A AD +QL +G LG + P T ++D
Sbjct: 2787 LTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDLGSGDTHTMIP--TKIND 2844
Query: 107 SIPHTVVLTVVEGWATLSVDGFLNASSAVPGAP-LEVPYGLFVGGTGTLGLPYLRGTSR- 164
H + + + L VDG N + + A L+V L+VGG LP T R
Sbjct: 2845 GQWHKIKIMRSKQEGILYVDGASNRTISPKKADILDVVGMLYVGG-----LPINYTTRRI 2899
Query: 165 -----PLRGC---LHAATLNGRSLLRPLTPDVHEGCAEEFSASDDVALGFSGPHSLAAFP 216
+ GC LH A + L T H G A+ F G A
Sbjct: 2900 GPVTYSIDGCVRNLHMA--EAPADLEQPTSSFHVGTC---FANAQRGTYFDGTGFAKAVG 2954
Query: 217 AWGTQDEGTLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQG--TVLLH 274
+ + +EF T + L ++ D + +++ + L V+ G G T +
Sbjct: 2955 GFKVGLDLLVEFEFRTTTTTGVL-LGISSQKMDGMGIEMIDEKLMFHVDNGAGRFTAVYD 3013
Query: 275 NSVP--VADGQPHEVSVHINAHRLEISVD--QYPTHTSNRGVLSYLEPRGSLLLGGLDAE 330
VP + DGQ H+V+ + HR+E++VD Q + N S + + +GG +
Sbjct: 3014 AGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTS-ADTNDPVFVGGFPDD 3072
Query: 331 ASRHLQEHRLGLTPEATNASLLGCMEDLSV 360
+ GLT T+ GC+ L +
Sbjct: 3073 LK------QFGLT---TSIPFRGCIRSLKL 3093
Score = 35.4 bits (80), Expect = 0.66
Identities = 41/204 (20%), Positives = 79/204 (38%), Gaps = 15/204 (7%)
Query: 190 EGCAEEFSASD-DVALGFSGP-HSLAAFPAWGTQDEGTLEFTLTTQSRQAPLAFQAGGRR 247
+GC D + + F G ++L + P + T+ F T S A L + A
Sbjct: 2326 KGCTVSPQVEDSEGTIQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDL 2385
Query: 248 GDFIYVDIFEGHLRAVVEKGQGTVLLHNSVPVADGQPHEVSVHINAHRLEISV------- 300
DF+ V++ +GH++ + G G + ++ DG+ ++ + IS+
Sbjct: 2386 RDFMSVELTDGHIKVSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQ 2445
Query: 301 -DQYPTHTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLTPEATNASLLGCMEDLS 359
+ T +S L+ + GGL L+ + PE GC++D+
Sbjct: 2446 EENIATSSSGNNFGLDLKADDKIYFGGLPT-----LRNLSMKARPEVNLKKYSGCLKDIE 2500
Query: 360 VNGQRRGLREALLTRNMAAGCRLE 383
++ + + + GC LE
Sbjct: 2501 ISRTPYNILSSPDYVGVTKGCSLE 2524
>gi|38045910 laminin alpha 3 subunit isoform 1 [Homo sapiens]
Length = 3333
Score = 44.7 bits (104), Expect = 0.001
Identities = 76/324 (23%), Positives = 130/324 (40%), Gaps = 23/324 (7%)
Query: 53 LQFSTSQPEALLLLAAGPADHLLLQLYSGRLQVRLVLGQEELRLQTPAETLLSDSIPHTV 112
+ T+ L+ + L L GRL LG + +L+ ++ +D HTV
Sbjct: 3014 VDMQTTSSRGLVFHTGTKNSFMALYLSKGRLV--FALGTDGKKLRIKSKEKCNDGKWHTV 3071
Query: 113 VLTVVEGWATLSVDGFLNASSAVPG-APLEVPYGLFVGGTGTLGLPYLRGTSRPLRGCLH 171
V L VDG ++PG + + + +++G + G P T+ + GCL
Sbjct: 3072 VFGHDGEKGRLVVDGLRAREGSLPGNSTISIRAPVYLGSPPS-GKPKSLPTNSFV-GCLK 3129
Query: 172 AATLNGRSLLRPLTPDVHEGCAEEFSASDDVALGFS--GPHSLAAFPAWGTQDEGTLEFT 229
L+ + L TP G + + + FS G H + A E L F+
Sbjct: 3130 NFQLDSKPLY---TPSSSFGVSSCLGGPLEKGIYFSEEGGHVVLAHSVL-LGPEFKLVFS 3185
Query: 230 LTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQG--TVLLHNSVPVADGQPHEV 287
+ +S L G + G + V + G + A ++ G G + + + DGQ H V
Sbjct: 3186 IRPRSLTGIL-IHIGSQPGKHLCVYLEAGKVTASMDSGAGGTSTSVTPKQSLCDGQWHSV 3244
Query: 288 SVHINAHRLEISVDQYPTHTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLTPEAT 347
+V I H L + +D ++T+ + + L LGG A +L R+ +
Sbjct: 3245 AVTIKQHILHLELDTDSSYTAGQIPFPPASTQEPLHLGG----APANLTTLRIPVW---- 3296
Query: 348 NASLLGCMEDLSVNGQRRGLREAL 371
S GC+ ++ VN + EAL
Sbjct: 3297 -KSFFGCLRNIHVNHIPVPVTEAL 3319
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 97,007,397
Number of Sequences: 37866
Number of extensions: 4894951
Number of successful extensions: 16505
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 71
Number of HSP's that attempted gapping in prelim test: 15586
Number of HSP's gapped (non-prelim): 465
length of query: 2322
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2203
effective length of database: 13,741,464
effective search space: 30272445192
effective search space used: 30272445192
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.