Search of human proteins with 46592956

Search of human proteins with 46592956

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|46592956 ATP-binding cassette sub-family G member 1 isoform
3 [Homo sapiens]
         (677 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3...  1348   0.0  
gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7...  1303   0.0  
gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2...  1303   0.0  
gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5...  1301   0.0  
gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4...  1294   0.0  
gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6...  1286   0.0  
gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo s...   922   0.0  
gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo sa...   922   0.0  
gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo s...   261   1e-69
gi|11967971 ATP-binding cassette sub-family G member 8 [Homo sap...   226   5e-59
gi|11967969 ATP-binding cassette sub-family G member 5 [Homo sap...   209   5e-54
gi|27881501 ATP-binding cassette, sub-family A, member 12 isofor...    91   3e-18
gi|30795238 ATP-binding cassette, sub-family A, member 12 isofor...    91   3e-18
gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo s...    90   6e-18
gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo...    89   1e-17
gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13...    87   7e-17
gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo sa...    86   1e-16
gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo s...    82   1e-15
gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo s...    82   2e-15
gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo ...    82   2e-15
gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo ...    82   2e-15
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B...    81   4e-15
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C...    81   4e-15
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A...    81   4e-15
gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform...    81   4e-15
gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform...    81   4e-15
gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo ...    81   4e-15
gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member ...    80   6e-15
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ...    80   6e-15
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member...    80   6e-15

>gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3
           [Homo sapiens]
          Length = 677

 Score = 1348 bits (3488), Expect = 0.0
 Identities = 677/677 (100%), Positives = 677/677 (100%)

Query: 1   MRISLPRAPERDGGVSASSLLDTVTNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLL 60
           MRISLPRAPERDGGVSASSLLDTVTNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLL
Sbjct: 1   MRISLPRAPERDGGVSASSLLDTVTNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLL 60

Query: 61  NGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFN 120
           NGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFN
Sbjct: 61  NGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFN 120

Query: 121 SGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLL 180
           SGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLL
Sbjct: 121 SGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLL 180

Query: 181 PHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIAL 240
           PHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIAL
Sbjct: 181 PHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIAL 240

Query: 241 ELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYV 300
           ELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYV
Sbjct: 241 ELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYV 300

Query: 301 LSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMC 360
           LSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMC
Sbjct: 301 LSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMC 360

Query: 361 DSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSV 420
           DSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSV
Sbjct: 361 DSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSV 420

Query: 421 LTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEM 480
           LTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEM
Sbjct: 421 LTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEM 480

Query: 481 GVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALG 540
           GVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALG
Sbjct: 481 GVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALG 540

Query: 541 TMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISY 600
           TMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISY
Sbjct: 541 TMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISY 600

Query: 601 VRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFIS 660
           VRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFIS
Sbjct: 601 VRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFIS 660

Query: 661 LRLIAYFVLRYKIRAER 677
           LRLIAYFVLRYKIRAER
Sbjct: 661 LRLIAYFVLRYKIRAER 677


>gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7
           [Homo sapiens]
          Length = 663

 Score = 1303 bits (3372), Expect = 0.0
 Identities = 653/653 (100%), Positives = 653/653 (100%)

Query: 25  TNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRA 84
           TNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRA
Sbjct: 11  TNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRA 70

Query: 85  AVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAG 144
           AVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAG
Sbjct: 71  AVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAG 130

Query: 145 YRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGR 204
           YRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGR
Sbjct: 131 YRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGR 190

Query: 205 REMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCF 264
           REMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCF
Sbjct: 191 REMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCF 250

Query: 265 QVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGL 324
           QVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGL
Sbjct: 251 QVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGL 310

Query: 325 NCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSE 384
           NCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSE
Sbjct: 311 NCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSE 370

Query: 385 EDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIG 444
           EDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIG
Sbjct: 371 EDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIG 430

Query: 445 NEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMA 504
           NEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMA
Sbjct: 431 NEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMA 490

Query: 505 DVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVA 564
           DVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVA
Sbjct: 491 DVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVA 550

Query: 565 TFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDI 624
           TFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDI
Sbjct: 551 TFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDI 610

Query: 625 DETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAER 677
           DETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAER
Sbjct: 611 DETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAER 663


>gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2
           [Homo sapiens]
          Length = 666

 Score = 1303 bits (3372), Expect = 0.0
 Identities = 654/661 (98%), Positives = 656/661 (99%)

Query: 17  ASSLLDTVTNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQR 76
           A+  + T  NASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQR
Sbjct: 6   AAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQR 65

Query: 77  FSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKS 136
           FSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKS
Sbjct: 66  FSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKS 125

Query: 137 TLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLK 196
           TLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLK
Sbjct: 126 TLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLK 185

Query: 197 LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTS 256
           LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTS
Sbjct: 186 LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTS 245

Query: 257 GLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLV 316
           GLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLV
Sbjct: 246 GLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLV 305

Query: 317 PYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNP 376
           PYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNP
Sbjct: 306 PYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNP 365

Query: 377 FLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLI 436
           FLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLI
Sbjct: 366 FLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLI 425

Query: 437 GLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKA 496
           GLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKA
Sbjct: 426 GLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKA 485

Query: 497 YYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGA 556
           YYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGA
Sbjct: 486 YYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGA 545

Query: 557 ASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLD 616
           ASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLD
Sbjct: 546 ASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLD 605

Query: 617 REDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAE 676
           REDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAE
Sbjct: 606 REDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAE 665

Query: 677 R 677
           R
Sbjct: 666 R 666


>gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5
           [Homo sapiens]
          Length = 668

 Score = 1301 bits (3367), Expect = 0.0
 Identities = 652/652 (100%), Positives = 652/652 (100%)

Query: 26  NASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAA 85
           NASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAA
Sbjct: 17  NASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAA 76

Query: 86  VNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGY 145
           VNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGY
Sbjct: 77  VNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGY 136

Query: 146 RETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRR 205
           RETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRR
Sbjct: 137 RETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRR 196

Query: 206 EMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQ 265
           EMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQ
Sbjct: 197 EMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQ 256

Query: 266 VVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLN 325
           VVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLN
Sbjct: 257 VVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLN 316

Query: 326 CPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEE 385
           CPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEE
Sbjct: 317 CPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEE 376

Query: 386 DSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGN 445
           DSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGN
Sbjct: 377 DSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGN 436

Query: 446 EAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMAD 505
           EAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMAD
Sbjct: 437 EAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMAD 496

Query: 506 VPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVAT 565
           VPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVAT
Sbjct: 497 VPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVAT 556

Query: 566 FVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDID 625
           FVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDID
Sbjct: 557 FVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDID 616

Query: 626 ETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAER 677
           ETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAER
Sbjct: 617 ETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAER 668


>gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4
           [Homo sapiens]
          Length = 678

 Score = 1294 bits (3349), Expect = 0.0
 Identities = 654/673 (97%), Positives = 656/673 (97%), Gaps = 12/673 (1%)

Query: 17  ASSLLDTVTNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQR 76
           A+  + T  NASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQR
Sbjct: 6   AAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQR 65

Query: 77  FSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKS 136
           FSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKS
Sbjct: 66  FSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKS 125

Query: 137 TLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLK 196
           TLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLK
Sbjct: 126 TLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLK 185

Query: 197 LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTS 256
           LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTS
Sbjct: 186 LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTS 245

Query: 257 GLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLV 316
           GLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLV
Sbjct: 246 GLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLV 305

Query: 317 PYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNP 376
           PYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNP
Sbjct: 306 PYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNP 365

Query: 377 FLWHRPSEE------------DSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHL 424
           FLWHRPSEE            DSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHL
Sbjct: 366 FLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHL 425

Query: 425 RITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFL 484
           RITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFL
Sbjct: 426 RITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFL 485

Query: 485 REHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTS 544
           REHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTS
Sbjct: 486 REHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTS 545

Query: 545 LVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYG 604
           LVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYG
Sbjct: 546 LVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYG 605

Query: 605 FEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLI 664
           FEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLI
Sbjct: 606 FEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLI 665

Query: 665 AYFVLRYKIRAER 677
           AYFVLRYKIRAER
Sbjct: 666 AYFVLRYKIRAER 678


>gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6
           [Homo sapiens]
          Length = 644

 Score = 1286 bits (3329), Expect = 0.0
 Identities = 644/644 (100%), Positives = 644/644 (100%)

Query: 34  MTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDL 93
           MTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDL
Sbjct: 1   MTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDL 60

Query: 94  SYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGA 153
           SYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGA
Sbjct: 61  SYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGA 120

Query: 154 VLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILT 213
           VLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILT
Sbjct: 121 VLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILT 180

Query: 214 ALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGL 273
           ALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGL
Sbjct: 181 ALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGL 240

Query: 274 AQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPA 333
           AQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPA
Sbjct: 241 AQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPA 300

Query: 334 DFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGC 393
           DFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGC
Sbjct: 301 DFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGC 360

Query: 394 HSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSN 453
           HSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSN
Sbjct: 361 HSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSN 420

Query: 454 SGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFP 513
           SGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFP
Sbjct: 421 SGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFP 480

Query: 514 VAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAI 573
           VAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAI
Sbjct: 481 VAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAI 540

Query: 574 PVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKS 633
           PVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKS
Sbjct: 541 PVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKS 600

Query: 634 EAILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAER 677
           EAILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAER
Sbjct: 601 EAILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAER 644


>gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo
           sapiens]
          Length = 646

 Score =  922 bits (2383), Expect = 0.0
 Identities = 459/625 (73%), Positives = 536/625 (85%), Gaps = 4/625 (0%)

Query: 53  EATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLL 112
           +  E  +L  HLKKV+N++TEAQRFS LP+R+AV+IEF +LSYSV EGP WRK+GYKTLL
Sbjct: 26  DGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVDIEFVELSYSVREGPCWRKRGYKTLL 85

Query: 113 KGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCY 172
           K +SGKF   EL+ IMGPSGAGKST MNILAGYRE+GMKG +L+NG PR+LR FRK+SCY
Sbjct: 86  KCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELRTFRKMSCY 145

Query: 173 IMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQ 232
           IMQDDMLLPHLTV EAMMVSA+LKL EK E ++E+V EILTALGL+SC++TRT  LSGGQ
Sbjct: 146 IMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQ 205

Query: 233 RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLF 292
           RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK LAQGGR+IICTIHQPSAKLF
Sbjct: 206 RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLF 265

Query: 293 ELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLV 352
           E+FD+LY+LSQGQC+++G V NL+PYL+ LGL+CPTYHNPADF++EVASGEYGD N  L 
Sbjct: 266 EMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPMLF 325

Query: 353 RAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTF 412
           RAV+ G+C    K+      EV       P E D       H+F+ S LTQFCILFKRTF
Sbjct: 326 RAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDPIE---SHTFATSTLTQFCILFKRTF 382

Query: 413 LSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPT 472
           LSI+RD+VLTHLR  SH+ IG+LIGLLYL IG++A KV +N+G LFFSMLFLMFAALMPT
Sbjct: 383 LSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKVFNNTGCLFFSMLFLMFAALMPT 442

Query: 473 VLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVR 532
           VLTFPLEM VF+REHLNYWYSLKAYYLAKTMADVPFQ++ PV YCSIVYWMT QP++  R
Sbjct: 443 VLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQPAETSR 502

Query: 533 FVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYL 592
           F+LF+AL T T+LVAQSLGLLIGAAS SLQVATFVGPVTAIPVLLFSGFFVSF TIPTYL
Sbjct: 503 FLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYL 562

Query: 593 QWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFI 652
           QW SY+SYVRYGFEGVIL+IYG++R DL C ++E C F++ ++ILR LDVE+AKLY+DF+
Sbjct: 563 QWSSYLSYVRYGFEGVILTIYGMERGDLTC-LEERCPFREPQSILRALDVEDAKLYMDFL 621

Query: 653 VLGIFFISLRLIAYFVLRYKIRAER 677
           VLGIFF++LRL+AY VLRY++++ER
Sbjct: 622 VLGIFFLALRLLAYLVLRYRVKSER 646


>gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo
           sapiens]
          Length = 646

 Score =  922 bits (2383), Expect = 0.0
 Identities = 459/625 (73%), Positives = 536/625 (85%), Gaps = 4/625 (0%)

Query: 53  EATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLL 112
           +  E  +L  HLKKV+N++TEAQRFS LP+R+AV+IEF +LSYSV EGP WRK+GYKTLL
Sbjct: 26  DGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVDIEFVELSYSVREGPCWRKRGYKTLL 85

Query: 113 KGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCY 172
           K +SGKF   EL+ IMGPSGAGKST MNILAGYRE+GMKG +L+NG PR+LR FRK+SCY
Sbjct: 86  KCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELRTFRKMSCY 145

Query: 173 IMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQ 232
           IMQDDMLLPHLTV EAMMVSA+LKL EK E ++E+V EILTALGL+SC++TRT  LSGGQ
Sbjct: 146 IMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQ 205

Query: 233 RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLF 292
           RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK LAQGGR+IICTIHQPSAKLF
Sbjct: 206 RKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLF 265

Query: 293 ELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLV 352
           E+FD+LY+LSQGQC+++G V NL+PYL+ LGL+CPTYHNPADF++EVASGEYGD N  L 
Sbjct: 266 EMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPMLF 325

Query: 353 RAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTF 412
           RAV+ G+C    K+      EV       P E D       H+F+ S LTQFCILFKRTF
Sbjct: 326 RAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDPIE---SHTFATSTLTQFCILFKRTF 382

Query: 413 LSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPT 472
           LSI+RD+VLTHLR  SH+ IG+LIGLLYL IG++A KV +N+G LFFSMLFLMFAALMPT
Sbjct: 383 LSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKVFNNTGCLFFSMLFLMFAALMPT 442

Query: 473 VLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVR 532
           VLTFPLEM VF+REHLNYWYSLKAYYLAKTMADVPFQ++ PV YCSIVYWMT QP++  R
Sbjct: 443 VLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQPAETSR 502

Query: 533 FVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYL 592
           F+LF+AL T T+LVAQSLGLLIGAAS SLQVATFVGPVTAIPVLLFSGFFVSF TIPTYL
Sbjct: 503 FLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYL 562

Query: 593 QWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFI 652
           QW SY+SYVRYGFEGVIL+IYG++R DL C ++E C F++ ++ILR LDVE+AKLY+DF+
Sbjct: 563 QWSSYLSYVRYGFEGVILTIYGMERGDLTC-LEERCPFREPQSILRALDVEDAKLYMDFL 621

Query: 653 VLGIFFISLRLIAYFVLRYKIRAER 677
           VLGIFF++LRL+AY VLRY++++ER
Sbjct: 622 VLGIFFLALRLLAYLVLRYRVKSER 646


>gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo
           sapiens]
          Length = 655

 Score =  261 bits (667), Expect = 1e-69
 Identities = 163/530 (30%), Positives = 293/530 (55%), Gaps = 35/530 (6%)

Query: 104 RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRD 162
           RK   K +L  I+G    G L AI+GP+G GKS+L+++LA  ++ +G+ G VLING PR 
Sbjct: 56  RKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRP 114

Query: 163 LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK--DEGRREMVKEILTALGLLSC 220
              F+  S Y++QDD+++  LTV+E +  SA L+L     +  + E +  ++  LGL   
Sbjct: 115 AN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKV 173

Query: 221 ANTRTGS-----LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQ 275
           A+++ G+     +SGG+RKR +I +EL+ +P ++F DEPT+GLDS++   V+ L+K +++
Sbjct: 174 ADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSK 233

Query: 276 GGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADF 335
            GR+II +IHQP   +F+LFD L +L+ G+ ++ G     + Y    G +C  Y+NPADF
Sbjct: 234 QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADF 293

Query: 336 VMEVASG-------------------EYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNP 376
            +++ +G                   E   Q+  L+  + E   +S   ++    AE++ 
Sbjct: 294 FLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKET--KAELHQ 351

Query: 377 FLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLI 436
                  ++ +   E   S++ S   Q   + KR+F +++ +   +  +I   + +GL+I
Sbjct: 352 LSGGEKKKKITVFKE--ISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVI 409

Query: 437 GLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKA 496
           G +Y G+ N++  + + +G LFF      F+++    L F +E  +F+ E+++ +Y + +
Sbjct: 410 GAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVSS 468

Query: 497 YYLAKTMAD-VPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIG 555
           Y+L K ++D +P +++  + +  IVY+M      A  F +      M +  A S+ L I 
Sbjct: 469 YFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIA 528

Query: 556 AASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGF 605
           A  + + VAT +  +  + +++FSG  V+  TI ++L W+ Y S  RYGF
Sbjct: 529 AGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGF 578


>gi|11967971 ATP-binding cassette sub-family G member 8 [Homo
           sapiens]
          Length = 673

 Score =  226 bits (576), Expect = 5e-59
 Identities = 160/624 (25%), Positives = 290/624 (46%), Gaps = 52/624 (8%)

Query: 88  IEFRDLSYSVP---EGPWWRKKGYKTL--------------LKGISGKFNSGELVAIMGP 130
           +E RDL+Y V    + PW+ +     +              ++ +S K  SG+++AI+G 
Sbjct: 47  LEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELGIQNLSFKVRSGQMLAIIGS 106

Query: 131 SGAGKSTLMNILAGYRETGM--KGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEA 188
           SG G+++L++++ G    G    G + ING P   +  RK   ++ Q + LLP+LTV+E 
Sbjct: 107 SGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRET 166

Query: 189 MMVSAHLKLQE--KDEGRREMVKEILTALGLLSCANTRTGS-----LSGGQRKRLAIALE 241
           +   A ++L        R + V++++  L L  CA+TR G+     LSGG+R+R++I ++
Sbjct: 167 LAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQ 226

Query: 242 LVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVL 301
           L+ NP ++  DEPTSGLDS +   +V  +  LA+G R ++ ++HQP + +F LFD + ++
Sbjct: 227 LLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLM 286

Query: 302 SQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCD 361
           + G  +Y G   ++V Y   +G  CP Y NPADF +++ S    D+ SR           
Sbjct: 287 TSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTS---IDRRSREQELATREKAQ 343

Query: 362 SDHKRDLGGDAEVNPFLWH---RPSEEDSSSMEGCHSFSASCL----------TQFCILF 408
           S     L    +++ FLW    +  +ED+           +CL           QF  L 
Sbjct: 344 SLAALFLEKVRDLDDFLWKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLI 403

Query: 409 KRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAA 468
           +R   +  RD     +       + + IG LY G G+     +  +  LF     + F  
Sbjct: 404 RRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAALLFMIGALIPFNV 463

Query: 469 LMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPS 528
           ++  +     E  +   E  +  Y+   Y+ AK + ++P    + + Y    YW+ +   
Sbjct: 464 ILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRP 523

Query: 529 DAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTI 588
               F+L   L  +     + + L   A   +  +A+F          L  GF ++  ++
Sbjct: 524 GLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSL 583

Query: 589 PTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLY 648
            T   W+S +S++R+ FEG++   +   R      +         + IL  +++++  LY
Sbjct: 584 WTVPAWISKVSFLRWCFEGLMKIQF--SRRTYKMPLGNLTIAVSGDKILSVMELDSYPLY 641

Query: 649 -LDFIVLG-------IFFISLRLI 664
            +  IV+G       ++++SLR I
Sbjct: 642 AIYLIVIGLSGGFMVLYYVSLRFI 665


>gi|11967969 ATP-binding cassette sub-family G member 5 [Homo
           sapiens]
          Length = 651

 Score =  209 bits (533), Expect = 5e-54
 Identities = 160/614 (26%), Positives = 302/614 (49%), Gaps = 45/614 (7%)

Query: 94  SYSVPEG--PWW-----RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGY- 145
           SYSV     PWW     R++  + +LK +S    SG+++ I+G SG+GK+TL++ ++G  
Sbjct: 44  SYSVSHRVRPWWDITSCRQQWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRL 103

Query: 146 -RETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGR 204
            R     G V +NG       F+    Y++Q D LL  LTV+E +  +A L ++  + G 
Sbjct: 104 GRAGTFLGEVYVNGRALRREQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGS 163

Query: 205 -REMVKEILTALGLLSCA-----NTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGL 258
            ++ V+ ++  L L   A     N   G +S G+R+R++IA +L+ +P VM FDEPT+GL
Sbjct: 164 FQKKVEAVMAELSLSHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGL 223

Query: 259 DSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPY 318
           D  +  Q+V L+  LA+  R ++ TIHQP ++LF+LFD++ +LS G+ ++ G    ++ +
Sbjct: 224 DCMTANQIVVLLVELARRNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDF 283

Query: 319 LRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFL 378
             D G  CP + NP DF M++ S +   +   +  + R  M +S +K+           +
Sbjct: 284 FNDCGYPCPEHSNPFDFYMDLTSVDTQSKEREIETSKRVQMIESAYKKSA---------I 334

Query: 379 WHRPSEEDSSSMEGCHSF---------SASCLTQFCILFKRTFLSIMRDSVLTHLRITSH 429
            H+ + ++   M+   +          S    ++  +L +R   +++R+ +    R+  +
Sbjct: 335 CHK-TLKNIERMKHLKTLPMVPFKTKDSPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQN 393

Query: 430 IGIGLLIGLLYLGIGNEAKK--VLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREH 487
           + +GL +    L + +   K  +    G L+  +    +  ++  V  FP+   V  +E 
Sbjct: 394 LIMGLFLLFFVLRVRSNVLKGAIQDRVGLLYQFVGATPYTGMLNAVNLFPVLRAVSDQES 453

Query: 488 LNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVA 547
            +  Y      LA  +  +PF ++  + + S+ YW      +  RF  F+A      L+ 
Sbjct: 454 QDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYFSAALLAPHLIG 513

Query: 548 QSLGL-LIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFE 606
           + L L L+G       V + V  ++   VL+ SGF  +   +P   + +SY ++ +Y  E
Sbjct: 514 EFLTLVLLGIVQNPNIVNSVVALLSIAGVLVGSGFLRNIQEMPIPFKIISYFTFQKYCSE 573

Query: 607 GVILS-IYGLD----REDLHCDIDETCHF-QKSEAILRELDVENAKLYLDFIVLGIFFIS 660
            ++++  YGL+      ++    +  C F Q  + I +      ++  ++F++L  F  +
Sbjct: 574 ILVVNEFYGLNFTCGSSNVSVTTNPMCAFTQGIQFIEKTCPGATSRFTMNFLILYSFIPA 633

Query: 661 LRLIAYFVLRYKIR 674
           L ++   V  +KIR
Sbjct: 634 LVILGIVV--FKIR 645


>gi|27881501 ATP-binding cassette, sub-family A, member 12 isoform b
            [Homo sapiens]
          Length = 2277

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 63/219 (28%), Positives = 112/219 (51%), Gaps = 6/219 (2%)

Query: 89   EFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRET 148
            E +DL+  V      +  G K  +  ++  F  G + +++GP+GAGK+T +++L G    
Sbjct: 1020 EPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGA 1079

Query: 149  GMKGAVLING--LPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGR-R 205
               G + + G  +  DL   RK     MQ D+L  +LT +E +++   +K+    + +  
Sbjct: 1080 SA-GTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLH 1138

Query: 206  EMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQ 265
            E VK  L   GL S  + R G+LSGG +++L+I++ L+    V+  DEP++G+D  S   
Sbjct: 1139 EEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRS 1198

Query: 266  VVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQG 304
            +  ++         I+ T H   A++  L D++  L QG
Sbjct: 1199 IWDVISKNKTARTIILSTHHLDEAEV--LSDRIAFLEQG 1235



 Score = 66.2 bits (160), Expect = 9e-11
 Identities = 53/178 (29%), Positives = 86/178 (48%), Gaps = 7/178 (3%)

Query: 112  LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSC 171
            +  IS    +GE   ++G +GAGK+T+  +L G       G +LI      L      S 
Sbjct: 1955 VNNISIGIPAGECFGLLGVNGAGKTTIFKMLTG-DIIPSSGNILIRNKTGSLGHVDSHSS 2013

Query: 172  ---YIMQDDMLLPHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGS 227
               Y  Q+D L   +TV+E +   A +  + EKD   +E V ++L  L L+   +  T  
Sbjct: 2014 LVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDI--KETVHKLLRRLHLMPFKDRATSM 2071

Query: 228  LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 285
             S G +++L+ AL L+  P ++  DEP+SG+D  S   +  ++    Q   S+I T H
Sbjct: 2072 CSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSH 2129


>gi|30795238 ATP-binding cassette, sub-family A, member 12 isoform a
            [Homo sapiens]
          Length = 2595

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 63/219 (28%), Positives = 112/219 (51%), Gaps = 6/219 (2%)

Query: 89   EFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRET 148
            E +DL+  V      +  G K  +  ++  F  G + +++GP+GAGK+T +++L G    
Sbjct: 1338 EPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGA 1397

Query: 149  GMKGAVLING--LPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGR-R 205
               G + + G  +  DL   RK     MQ D+L  +LT +E +++   +K+    + +  
Sbjct: 1398 SA-GTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLH 1456

Query: 206  EMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQ 265
            E VK  L   GL S  + R G+LSGG +++L+I++ L+    V+  DEP++G+D  S   
Sbjct: 1457 EEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRS 1516

Query: 266  VVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQG 304
            +  ++         I+ T H   A++  L D++  L QG
Sbjct: 1517 IWDVISKNKTARTIILSTHHLDEAEV--LSDRIAFLEQG 1553



 Score = 66.2 bits (160), Expect = 9e-11
 Identities = 53/178 (29%), Positives = 86/178 (48%), Gaps = 7/178 (3%)

Query: 112  LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSC 171
            +  IS    +GE   ++G +GAGK+T+  +L G       G +LI      L      S 
Sbjct: 2273 VNNISIGIPAGECFGLLGVNGAGKTTIFKMLTG-DIIPSSGNILIRNKTGSLGHVDSHSS 2331

Query: 172  ---YIMQDDMLLPHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGS 227
               Y  Q+D L   +TV+E +   A +  + EKD   +E V ++L  L L+   +  T  
Sbjct: 2332 LVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDI--KETVHKLLRRLHLMPFKDRATSM 2389

Query: 228  LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 285
             S G +++L+ AL L+  P ++  DEP+SG+D  S   +  ++    Q   S+I T H
Sbjct: 2390 CSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSH 2447


>gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo
            sapiens]
          Length = 2273

 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 63/194 (32%), Positives = 100/194 (51%), Gaps = 6/194 (3%)

Query: 119  FNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDLRCFRKVSCYIMQD 176
            F   ++ A +G +GAGK+T ++IL G       G VL+ G  +   L   R+      Q 
Sbjct: 953  FYENQITAFLGHNGAGKTTTLSILTGLLPP-TSGTVLVGGRDIETSLDAVRQSLGMCPQH 1011

Query: 177  DMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRL 236
            ++L  HLTV E M+  A LK + ++E + EM + +L   GL    N     LSGG +++L
Sbjct: 1012 NILFHHLTVAEHMLFYAQLKGKSQEEAQLEM-EAMLEDTGLHHKRNEEAQDLSGGMQRKL 1070

Query: 237  AIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFD 296
            ++A+  V +  V+  DEPTSG+D  S   +  L+     G   I+ T H   A L  L D
Sbjct: 1071 SVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADL--LGD 1128

Query: 297  QLYVLSQGQCVYRG 310
            ++ +++QG+    G
Sbjct: 1129 RIAIIAQGRLYCSG 1142



 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 44/165 (26%), Positives = 85/165 (51%), Gaps = 2/165 (1%)

Query: 122  GELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLL 180
            GE   ++G +GAGK+T   +L G    T     V    +  ++    +   Y  Q D + 
Sbjct: 1965 GECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAID 2024

Query: 181  PHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIAL 240
              LT +E + + A L+    +E  + +    + +LGL   A+   G+ SGG +++L+ A+
Sbjct: 2025 ELLTGREHLYLYARLRGVPAEEIEK-VANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAI 2083

Query: 241  ELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 285
             L+  PP++  DEPT+G+D  +   + +++  + + GR+++ T H
Sbjct: 2084 ALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSH 2128


>gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo
           sapiens]
          Length = 1543

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 60/170 (35%), Positives = 92/170 (54%), Gaps = 4/170 (2%)

Query: 105 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLIN---GLPR 161
           K G    L+GI      G++ AI+G +GAGKSTL+NIL+G   +    A + N       
Sbjct: 403 KTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEIT 462

Query: 162 DLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCA 221
           D+   RK   +  Q +     LTV+E + V A +K  +  E  +E VK I+  L + S  
Sbjct: 463 DMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQE-VKRIIMELDMQSIQ 521

Query: 222 NTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 271
           +     LSGGQ+++L + + ++ +P V+  DEPT+GLD  S  +V SL+K
Sbjct: 522 DIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLK 571



 Score = 66.2 bits (160), Expect = 9e-11
 Identities = 51/190 (26%), Positives = 93/190 (48%), Gaps = 9/190 (4%)

Query: 104  RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDL 163
            RKK  K  ++ +S     GE++ ++G +GAGKST + ++ G  +    G V++ G    +
Sbjct: 1216 RKK--KIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKP-TAGVVVLQGSRASV 1272

Query: 164  RCFRKVSC----YIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLS 219
            R     S     Y  Q++ L P LT++E + + A +K   K++     +  ++ AL L  
Sbjct: 1273 RQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALS-ISRLVEALKLQE 1331

Query: 220  CANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GR 278
                   +LS G +++L   L ++ NP V+  DEP +G+D     Q+  +++   +   R
Sbjct: 1332 QLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKER 1391

Query: 279  SIICTIHQPS 288
              + T H  S
Sbjct: 1392 GTLLTTHYMS 1401


>gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13
            [Homo sapiens]
          Length = 5058

 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 59/203 (29%), Positives = 108/203 (53%), Gaps = 6/203 (2%)

Query: 106  KGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDL 163
            +G+K +++ +S  F   ++ A++G +GAGK+T++++L G       G ++ING  L  DL
Sbjct: 3852 EGHKAVVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPP-TSGTIIINGKNLQTDL 3910

Query: 164  RCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKL-QEKDEGRREMVKEILTALGLLSCAN 222
               R       Q D+LL +LTV+E +++ A +K  Q   +   + V + L  + L    +
Sbjct: 3911 SRVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQH 3970

Query: 223  TRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIIC 282
             +T +LSGG +++L++ +  +     +  DEPTSG+D  S   +  ++    +G   I  
Sbjct: 3971 KQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTIIFT 4030

Query: 283  TIHQPSAKLFELFDQLYVLSQGQ 305
            T H   A+   L D++ VL  G+
Sbjct: 4031 THHLDEAE--ALSDRVAVLQHGR 4051



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 48/176 (27%), Positives = 83/176 (47%), Gaps = 7/176 (3%)

Query: 112  LKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLIN--GLPRDLRCFRKV 169
            ++ IS     GE   ++G +GAGKST   +L G        A++    G   DL      
Sbjct: 4737 VQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTA 4796

Query: 170  SC---YIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTG 226
                 Y  Q D L   LT  E +     L+   + +   E+  +++  L L + A+    
Sbjct: 4797 GVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPR-QCIPEVAGDLIRRLHLEAHADKPVA 4855

Query: 227  SLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSAS-CFQVVSLMKGLAQGGRSII 281
            + SGG +++L+ AL LV  P ++  DEP+SG+D  S  +   ++MK + +G  +++
Sbjct: 4856 TYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVL 4911


>gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo
            sapiens]
          Length = 2261

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 59/202 (29%), Positives = 102/202 (50%), Gaps = 3/202 (1%)

Query: 105  KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGLPRDL 163
            + G K  + G++  F  G++ + +G +GAGK+T M+IL G +  T     +L   +  ++
Sbjct: 909  RDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEM 968

Query: 164  RCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANT 223
               R+      Q ++L   LTV+E +   A LK   +   + EM +  L      S   +
Sbjct: 969  STIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKS 1028

Query: 224  RTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICT 283
            +T  LSGG +++L++AL  V    V+  DEPT+G+D  S   +  L+    QG   I+ T
Sbjct: 1029 KTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILST 1088

Query: 284  IHQPSAKLFELFDQLYVLSQGQ 305
             H   A +  L D++ ++S G+
Sbjct: 1089 HHMDEADV--LGDRIAIISHGK 1108



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 49/166 (29%), Positives = 86/166 (51%), Gaps = 4/166 (2%)

Query: 122  GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLI-NGLPRDLRCFRKVSCYIMQDDMLL 180
            GE   ++G +GAGKS+   +L G        A L  N +  ++    +   Y  Q D + 
Sbjct: 1939 GECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAIT 1998

Query: 181  PHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIA 239
              LT +E +   A L+ + EK+ G+  + +  +  LGL+       G+ SGG +++L+ A
Sbjct: 1999 ELLTGREHVEFFALLRGVPEKEVGK--VGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTA 2056

Query: 240  LELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 285
            + L+  PPV+F DEPT+G+D  +   + +    + + GRS++ T H
Sbjct: 2057 MALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSH 2102


>gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo
           sapiens]
          Length = 1704

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 60/187 (32%), Positives = 104/187 (55%), Gaps = 8/187 (4%)

Query: 122 GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDLRCFRKVSCYIMQDDML 179
           G++  ++G +GAGK+T +++L G       G   I+G  + +D+   RK      Q D+L
Sbjct: 559 GQITVLLGHNGAGKTTTLSMLTGLFPP-TSGRAYISGYEISQDMVQIRKSLGLCPQHDIL 617

Query: 180 LPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIA 239
             +LTV E +   A LK   + +   E VK++L  +GL    N+R+  LSGG R++L+I 
Sbjct: 618 FDNLTVAEHLYFYAQLKGLSRQKCPEE-VKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIG 676

Query: 240 LELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH-QPSAKLFELFDQL 298
           + L+    V+  DEPTSG+D+ S   +  L++   +  R+I+ T H    A L  L D++
Sbjct: 677 IALIAGSKVLILDEPTSGMDAISRRAIWDLLQ-RQKSDRTIVLTTHFMDEADL--LGDRI 733

Query: 299 YVLSQGQ 305
            ++++G+
Sbjct: 734 AIMAKGE 740



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 56/187 (29%), Positives = 96/187 (51%), Gaps = 7/187 (3%)

Query: 122  GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDLRCFRKVSCYIMQDDML 179
            GE   ++G +GAGK+T   +L G  E+   G   + G  +  D+   R+   Y  Q D L
Sbjct: 1409 GECFGLLGFNGAGKTTTFKMLTG-EESLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDAL 1467

Query: 180  LPHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAI 238
            L H+T +E +++ A L+ + E+  G    V+  L  L L   AN    + SGG +++L+ 
Sbjct: 1468 LDHMTGREMLVMYARLRGIPERHIGA--CVENTLRGLLLEPHANKLVRTYSGGNKRKLST 1525

Query: 239  ALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQL 298
             + L+  P V+F DEP++G+D  +   +   +    + G++II T H    +   L  +L
Sbjct: 1526 GIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHS-MEECEALCTRL 1584

Query: 299  YVLSQGQ 305
             ++ QGQ
Sbjct: 1585 AIMVQGQ 1591


>gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo
           sapiens]
          Length = 1617

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 64/205 (31%), Positives = 104/205 (50%), Gaps = 8/205 (3%)

Query: 105 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLP---- 160
           K G    LKG+      G++ AI+G SGAGKS+L+NIL G      +G+V I        
Sbjct: 490 KSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGL-SVPTEGSVTIYNKNLSEM 548

Query: 161 RDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSC 220
           +DL   RK++    Q ++    LTV+E + + A +K     E  +E V+ IL  L + + 
Sbjct: 549 QDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQE-VQRILLELDMQNI 607

Query: 221 ANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSI 280
            +     LS GQ+++L   + ++ +P ++  DEPT+GLD  S  QV SL++        +
Sbjct: 608 QDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVIL 667

Query: 281 ICTIHQPSAKLFELFDQLYVLSQGQ 305
             T     A +  L D+  ++S G+
Sbjct: 668 FSTQSMDEADI--LADRKVIMSNGR 690



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 56/212 (26%), Positives = 106/212 (50%), Gaps = 8/212 (3%)

Query: 105  KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLR 164
            K+  K   + IS     GE++ ++GP+GAGKS+ + +++G  +    G V + G    L 
Sbjct: 1296 KRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKP-TAGEVELKGCSSVLG 1354

Query: 165  CFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTR 224
                   Y  Q+++L P LT++E + V A +K   K + R  + + +++A  L    N  
Sbjct: 1355 HLG----YCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIAR-LVSAFKLHEQLNVP 1409

Query: 225  TGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GRSIICT 283
               L+ G  ++L   L L+ N PV+  DEP++G+D     Q+   ++ + +   R ++ T
Sbjct: 1410 VQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLT 1469

Query: 284  IHQPSAKLFELFDQLYVLSQGQCVYRGKVCNL 315
             H   A+   L D++ ++  G+    G + +L
Sbjct: 1470 THN-LAEAEALCDRVAIMVSGRLRCIGSIQHL 1500


>gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo
           sapiens]
          Length = 1642

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 64/211 (30%), Positives = 109/211 (51%), Gaps = 9/211 (4%)

Query: 103 WRKKGYKT-LLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPR 161
           +RKKG     L+ +S     G++ A++G SG GKSTLMNIL G        A +      
Sbjct: 487 YRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVS 546

Query: 162 DLRCF---RKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLL 218
           ++      RK+     Q D+    LTV+E + + A +K    +   +E V+++L  L + 
Sbjct: 547 EIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQE-VQKVLLDLDMQ 605

Query: 219 SCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGR 278
           +  + +   LSGGQ+++L++ + ++ NP ++  DEPT+G+D  S   V +L+K       
Sbjct: 606 TIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRV 665

Query: 279 SIICTIHQPSAKLFELFDQLYVLSQG--QCV 307
           ++  T     A +  L D+  V+SQG  +CV
Sbjct: 666 TVFSTHFMDEADI--LADRKAVISQGMLKCV 694



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 49/162 (30%), Positives = 77/162 (47%), Gaps = 13/162 (8%)

Query: 105  KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRD-- 162
            +K  K   K IS     GE++ ++GP+GAGKST++NIL G  E    G V +     +  
Sbjct: 1309 RKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEP-TSGQVFLGDYSSETS 1367

Query: 163  -----LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGL 217
                 L+C      Y  Q + L P  T+QE   +   +K     +  +E++  I  AL L
Sbjct: 1368 EDDDSLKCMG----YCPQINPLWPDTTLQEHFEIYGAVKGMSASD-MKEVISRITHALDL 1422

Query: 218  LSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLD 259
                      L  G +++L  AL ++ NP +   DEP++G+D
Sbjct: 1423 KEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMD 1464


>gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo
           sapiens]
          Length = 1642

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 64/211 (30%), Positives = 109/211 (51%), Gaps = 9/211 (4%)

Query: 103 WRKKGYKT-LLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPR 161
           +RKKG     L+ +S     G++ A++G SG GKSTLMNIL G        A +      
Sbjct: 487 YRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVS 546

Query: 162 DLRCF---RKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLL 218
           ++      RK+     Q D+    LTV+E + + A +K    +   +E V+++L  L + 
Sbjct: 547 EIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQE-VQKVLLDLDMQ 605

Query: 219 SCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGR 278
           +  + +   LSGGQ+++L++ + ++ NP ++  DEPT+G+D  S   V +L+K       
Sbjct: 606 TIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRV 665

Query: 279 SIICTIHQPSAKLFELFDQLYVLSQG--QCV 307
           ++  T     A +  L D+  V+SQG  +CV
Sbjct: 666 TVFSTHFMDEADI--LADRKAVISQGMLKCV 694



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 49/162 (30%), Positives = 77/162 (47%), Gaps = 13/162 (8%)

Query: 105  KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRD-- 162
            +K  K   K IS     GE++ ++GP+GAGKST++NIL G  E    G V +     +  
Sbjct: 1309 RKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEP-TSGQVFLGDYSSETS 1367

Query: 163  -----LRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGL 217
                 L+C      Y  Q + L P  T+QE   +   +K     +  +E++  I  AL L
Sbjct: 1368 EDDDSLKCMG----YCPQINPLWPDTTLQEHFEIYGAVKGMSASD-MKEVISRITHALDL 1422

Query: 218  LSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLD 259
                      L  G +++L  AL ++ NP +   DEP++G+D
Sbjct: 1423 KEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMD 1464


>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
           [Homo sapiens]
          Length = 1286

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 66/232 (28%), Positives = 114/232 (49%), Gaps = 26/232 (11%)

Query: 87  NIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYR 146
           N+EF D+ +S P       +    +LKG++ K  SG+ VA++G SG GKST + ++    
Sbjct: 393 NLEFNDVHFSYPS------RANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLY 446

Query: 147 ETGMKGAVLINGLPRDLRCF-----RKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQE-- 199
           +   +G + I+G  +D+R F     R++   + Q+ +L      +       ++ + E  
Sbjct: 447 DPD-EGTINIDG--QDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIK 503

Query: 200 ---KDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTS 256
              K+    E + ++      L     R   LSGGQ++R+AIA  LV NP ++  DE TS
Sbjct: 504 KAVKEANAYEFIMKLPQKFDTL--VGERGAQLSGGQKQRIAIARALVRNPKILLLDEATS 561

Query: 257 GLDSASCFQVVSLMKGLAQGGRSIICTIHQPS----AKLFELFDQLYVLSQG 304
            LD+ S  +V + +   A+ GR+ I   H+ S    A +   F+   ++ QG
Sbjct: 562 ALDTESEAEVQAAL-DKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQG 612



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 60/248 (24%), Positives = 112/248 (45%), Gaps = 31/248 (12%)

Query: 81   PRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMN 140
            P +   NI F ++ ++ P       +    +L+G+S +   G+ +A++G SG GKST++ 
Sbjct: 1027 PDKFEGNITFNEVVFNYPT------RANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1080

Query: 141  ILAGYRETGMKGAVLIN----------GLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMM 190
            +L  + +  + G V ++              +++  R     + Q+ +L    ++ E + 
Sbjct: 1081 LLERFYDP-LAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFD-CSIAENIA 1138

Query: 191  VSAHLKLQEKDE----GRREMVKEILTALGLLSCANTRTGS----LSGGQRKRLAIALEL 242
               + ++  +DE     +   +   +  L       TR G     LSGGQ++R+AIA  L
Sbjct: 1139 YGDNSRVVSQDEIVSAAKAANIHPFIETLP--HKYETRVGDKGTQLSGGQKQRIAIARAL 1196

Query: 243  VNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLS 302
            +  P ++  DE TS LD+ S  +VV      A+ GR+ I   H+ S    +  D + V  
Sbjct: 1197 IRQPQILLLDEATSALDTES-EKVVQEALDKAREGRTCIVIAHRLST--IQNADLIVVFQ 1253

Query: 303  QGQCVYRG 310
             G+    G
Sbjct: 1254 NGRVKEHG 1261


>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
           [Homo sapiens]
          Length = 1232

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 66/232 (28%), Positives = 114/232 (49%), Gaps = 26/232 (11%)

Query: 87  NIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYR 146
           N+EF D+ +S P       +    +LKG++ K  SG+ VA++G SG GKST + ++    
Sbjct: 393 NLEFNDVHFSYPS------RANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLY 446

Query: 147 ETGMKGAVLINGLPRDLRCF-----RKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQE-- 199
           +   +G + I+G  +D+R F     R++   + Q+ +L      +       ++ + E  
Sbjct: 447 DPD-EGTINIDG--QDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIK 503

Query: 200 ---KDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTS 256
              K+    E + ++      L     R   LSGGQ++R+AIA  LV NP ++  DE TS
Sbjct: 504 KAVKEANAYEFIMKLPQKFDTL--VGERGAQLSGGQKQRIAIARALVRNPKILLLDEATS 561

Query: 257 GLDSASCFQVVSLMKGLAQGGRSIICTIHQPS----AKLFELFDQLYVLSQG 304
            LD+ S  +V + +   A+ GR+ I   H+ S    A +   F+   ++ QG
Sbjct: 562 ALDTESEAEVQAAL-DKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQG 612



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 62/240 (25%), Positives = 114/240 (47%), Gaps = 22/240 (9%)

Query: 81   PRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMN 140
            P +   NI F ++ ++ P       +    +L+G+S +   G+ +A++G SG GKST++ 
Sbjct: 980  PDKFEGNITFNEVVFNYPT------RANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1033

Query: 141  ILAGYRETGMKGAVLINGLP-RDLRC-FRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQ 198
            +L  + +  + G VL++G   + L   + +    I+  + +L   ++ E +    + ++ 
Sbjct: 1034 LLERFYDP-LAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVV 1092

Query: 199  EKDE----GRREMVKEILTALGLLSCANTRTGS----LSGGQRKRLAIALELVNNPPVMF 250
             +DE     +   +   +  L       TR G     LSGGQ++R+AIA  L+  P ++ 
Sbjct: 1093 SQDEIVSAAKAANIHPFIETLP--HKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILL 1150

Query: 251  FDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRG 310
             DE TS LD+ S  +VV      A+ GR+ I   H+ S    +  D + V   G+    G
Sbjct: 1151 LDEATSALDTES-EKVVQEALDKAREGRTCIVIAHRLST--IQNADLIVVFQNGRVKEHG 1207


>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
           [Homo sapiens]
          Length = 1279

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 66/232 (28%), Positives = 114/232 (49%), Gaps = 26/232 (11%)

Query: 87  NIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYR 146
           N+EF D+ +S P       +    +LKG++ K  SG+ VA++G SG GKST + ++    
Sbjct: 393 NLEFNDVHFSYPS------RANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLY 446

Query: 147 ETGMKGAVLINGLPRDLRCF-----RKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQE-- 199
           +   +G + I+G  +D+R F     R++   + Q+ +L      +       ++ + E  
Sbjct: 447 DPD-EGTINIDG--QDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIK 503

Query: 200 ---KDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTS 256
              K+    E + ++      L     R   LSGGQ++R+AIA  LV NP ++  DE TS
Sbjct: 504 KAVKEANAYEFIMKLPQKFDTL--VGERGAQLSGGQKQRIAIARALVRNPKILLLDEATS 561

Query: 257 GLDSASCFQVVSLMKGLAQGGRSIICTIHQPS----AKLFELFDQLYVLSQG 304
            LD+ S  +V + +   A+ GR+ I   H+ S    A +   F+   ++ QG
Sbjct: 562 ALDTESEAEVQAAL-DKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQG 612



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 62/240 (25%), Positives = 114/240 (47%), Gaps = 22/240 (9%)

Query: 81   PRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMN 140
            P +   NI F ++ ++ P       +    +L+G+S +   G+ +A++G SG GKST++ 
Sbjct: 1027 PDKFEGNITFNEVVFNYPT------RANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1080

Query: 141  ILAGYRETGMKGAVLINGLP-RDLRC-FRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQ 198
            +L  + +  + G VL++G   + L   + +    I+  + +L   ++ E +    + ++ 
Sbjct: 1081 LLERFYDP-LAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVV 1139

Query: 199  EKDE----GRREMVKEILTALGLLSCANTRTGS----LSGGQRKRLAIALELVNNPPVMF 250
             +DE     +   +   +  L       TR G     LSGGQ++R+AIA  L+  P ++ 
Sbjct: 1140 SQDEIVSAAKAANIHPFIETLP--HKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILL 1197

Query: 251  FDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRG 310
             DE TS LD+ S  +VV      A+ GR+ I   H+ S    +  D + V   G+    G
Sbjct: 1198 LDEATSALDTES-EKVVQEALDKAREGRTCIVIAHRLST--IQNADLIVVFQNGRVKEHG 1254


>gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform a
            [Homo sapiens]
          Length = 2436

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 54/167 (32%), Positives = 90/167 (53%), Gaps = 6/167 (3%)

Query: 122  GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDLRCFRKVSCYIMQDDML 179
            GE   ++G +GAGK++   +L G   T   G   +NG  + ++L   ++   Y  Q D L
Sbjct: 2081 GECFGLLGVNGAGKTSTFKMLTGDEST-TGGEAFVNGHSVLKELLQVQQSLGYCPQCDAL 2139

Query: 180  LPHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAI 238
               LT +E + +   L+ +  KDE R  +VK  L  L L   A+   G+ SGG +++L+ 
Sbjct: 2140 FDELTAREHLQLYTRLRGISWKDEAR--VVKWALEKLELTKYADKPAGTYSGGNKRKLST 2197

Query: 239  ALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 285
            A+ L+  P  +F DEPT+G+D  +   + +L+  L + GRS++ T H
Sbjct: 2198 AIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSH 2244



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 57/202 (28%), Positives = 103/202 (50%), Gaps = 4/202 (1%)

Query: 105  KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGLPRDL 163
            K   K  L  +S      ++V+ +G +GAGK+T M+IL G +  T     +  + +  ++
Sbjct: 1001 KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEM 1060

Query: 164  RCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANT 223
               RK      Q ++L   LTV+E +   + LK   ++E RREM K ++  L L +  ++
Sbjct: 1061 DEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDK-MIEDLELSNKRHS 1119

Query: 224  RTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICT 283
               +LSGG +++L++A+  V     +  DEPT+G+D  +   +  L+     G   ++ T
Sbjct: 1120 LVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLST 1179

Query: 284  IHQPSAKLFELFDQLYVLSQGQ 305
             H   A L  L D++ ++S G+
Sbjct: 1180 HHMDEADL--LGDRIAIISHGK 1199


>gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform b
            [Homo sapiens]
          Length = 2466

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 54/167 (32%), Positives = 90/167 (53%), Gaps = 6/167 (3%)

Query: 122  GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDLRCFRKVSCYIMQDDML 179
            GE   ++G +GAGK++   +L G   T   G   +NG  + ++L   ++   Y  Q D L
Sbjct: 2111 GECFGLLGVNGAGKTSTFKMLTGDEST-TGGEAFVNGHSVLKELLQVQQSLGYCPQCDAL 2169

Query: 180  LPHLTVQEAMMVSAHLK-LQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAI 238
               LT +E + +   L+ +  KDE R  +VK  L  L L   A+   G+ SGG +++L+ 
Sbjct: 2170 FDELTAREHLQLYTRLRGISWKDEAR--VVKWALEKLELTKYADKPAGTYSGGNKRKLST 2227

Query: 239  ALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 285
            A+ L+  P  +F DEPT+G+D  +   + +L+  L + GRS++ T H
Sbjct: 2228 AIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSH 2274



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 57/202 (28%), Positives = 103/202 (50%), Gaps = 4/202 (1%)

Query: 105  KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGLPRDL 163
            K   K  L  +S      ++V+ +G +GAGK+T M+IL G +  T     +  + +  ++
Sbjct: 1031 KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEM 1090

Query: 164  RCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANT 223
               RK      Q ++L   LTV+E +   + LK   ++E RREM K ++  L L +  ++
Sbjct: 1091 DEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDK-MIEDLELSNKRHS 1149

Query: 224  RTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICT 283
               +LSGG +++L++A+  V     +  DEPT+G+D  +   +  L+     G   ++ T
Sbjct: 1150 LVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLST 1209

Query: 284  IHQPSAKLFELFDQLYVLSQGQ 305
             H   A L  L D++ ++S G+
Sbjct: 1210 HHMDEADL--LGDRIAIISHGK 1229


>gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo
            sapiens]
          Length = 2146

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 65/227 (28%), Positives = 111/227 (48%), Gaps = 13/227 (5%)

Query: 81   PRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMN 140
            P   +  +  R L    P  P       +  L+G+S  F  G + A +G +GAGK+T ++
Sbjct: 800  PPGLSPGVSVRSLEKRFPGSP-------QPALRGLSLDFYQGHITAFLGHNGAGKTTTLS 852

Query: 141  ILAG-YRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLK-LQ 198
            IL+G +  +G    +L + +   +   R       Q ++L   LTV E +     LK L 
Sbjct: 853  ILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLS 912

Query: 199  EKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGL 258
                G  +    +L  +GL+S  + +T  LSGG +++L++A+  V    V+  DEPT+G+
Sbjct: 913  AAVVGPEQ--DRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGV 970

Query: 259  DSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQ 305
            D AS   +  L+    +G   I+ T H   A+L  L D++ V++ G+
Sbjct: 971  DPASRRGIWELLLKYREGRTLILSTHHLDEAEL--LGDRVAVVAGGR 1015



 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 49/165 (29%), Positives = 85/165 (51%), Gaps = 2/165 (1%)

Query: 122  GELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLI-NGLPRDLRCFRKVSCYIMQDDMLL 180
            GE   ++G +GAGK++   ++ G        AVL  + + R+         Y  Q D + 
Sbjct: 1820 GECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIF 1879

Query: 181  PHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIAL 240
              LT +E + + A L+   + +   +     L  LGL   A+   G+ SGG +++LA AL
Sbjct: 1880 ELLTGREHLELLARLRGVPEAQVA-QTAGSGLARLGLSWYADRPAGTYSGGNKRKLATAL 1938

Query: 241  ELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 285
             LV +P V+F DEPT+G+D ++   + + +  + + GRS++ T H
Sbjct: 1939 ALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSH 1983


>gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member 9
           isoform 2 [Homo sapiens]
          Length = 723

 Score = 80.1 bits (196), Expect = 6e-15
 Identities = 69/263 (26%), Positives = 122/263 (46%), Gaps = 42/263 (15%)

Query: 67  VDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVA 126
           +D   T     S  P      ++F +++++      +R + +  +L+ +S   + G++ A
Sbjct: 440 IDRQPTMVHDGSLAPDHLEGRVDFENVTFT------YRTRPHTQVLQNVSFSLSPGKVTA 493

Query: 127 IMGPSGAGKSTLMNILAGYRETGMKGAVLINGLP---RDLRCFRKVSCYIMQDDML---- 179
           ++GPSG+GKS+ +NIL  +      G VL++G P    D +   +V   + Q+ +L    
Sbjct: 494 LVGPSGSGKSSCVNILENFYPLE-GGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARS 552

Query: 180 --------LP----HLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGS 227
                   LP     + V+ A   +AH  + E  +G      E             +   
Sbjct: 553 ITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGE-------------KGAQ 599

Query: 228 LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQP 287
           LSGGQ++R+A+A  LV NPPV+  DE TS LD+ S + +   + G  Q   +++   H+ 
Sbjct: 600 LSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQ-KHTVLIIAHRL 658

Query: 288 SAKLFELFDQLYVLSQGQCVYRG 310
           S    E    + VL +G+ V +G
Sbjct: 659 ST--VEHAHLIVVLDKGRVVQQG 679


>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
           isoform 1 [Homo sapiens]
          Length = 766

 Score = 80.1 bits (196), Expect = 6e-15
 Identities = 69/263 (26%), Positives = 122/263 (46%), Gaps = 42/263 (15%)

Query: 67  VDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVA 126
           +D   T     S  P      ++F +++++      +R + +  +L+ +S   + G++ A
Sbjct: 483 IDRQPTMVHDGSLAPDHLEGRVDFENVTFT------YRTRPHTQVLQNVSFSLSPGKVTA 536

Query: 127 IMGPSGAGKSTLMNILAGYRETGMKGAVLINGLP---RDLRCFRKVSCYIMQDDML---- 179
           ++GPSG+GKS+ +NIL  +      G VL++G P    D +   +V   + Q+ +L    
Sbjct: 537 LVGPSGSGKSSCVNILENFYPLE-GGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARS 595

Query: 180 --------LP----HLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGS 227
                   LP     + V+ A   +AH  + E  +G      E             +   
Sbjct: 596 ITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGE-------------KGAQ 642

Query: 228 LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQP 287
           LSGGQ++R+A+A  LV NPPV+  DE TS LD+ S + +   + G  Q   +++   H+ 
Sbjct: 643 LSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQ-KHTVLIIAHRL 701

Query: 288 SAKLFELFDQLYVLSQGQCVYRG 310
           S    E    + VL +G+ V +G
Sbjct: 702 ST--VEHAHLIVVLDKGRVVQQG 722


>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
           isoform 1 [Homo sapiens]
          Length = 766

 Score = 80.1 bits (196), Expect = 6e-15
 Identities = 69/263 (26%), Positives = 122/263 (46%), Gaps = 42/263 (15%)

Query: 67  VDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVA 126
           +D   T     S  P      ++F +++++      +R + +  +L+ +S   + G++ A
Sbjct: 483 IDRQPTMVHDGSLAPDHLEGRVDFENVTFT------YRTRPHTQVLQNVSFSLSPGKVTA 536

Query: 127 IMGPSGAGKSTLMNILAGYRETGMKGAVLINGLP---RDLRCFRKVSCYIMQDDML---- 179
           ++GPSG+GKS+ +NIL  +      G VL++G P    D +   +V   + Q+ +L    
Sbjct: 537 LVGPSGSGKSSCVNILENFYPLE-GGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARS 595

Query: 180 --------LP----HLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGS 227
                   LP     + V+ A   +AH  + E  +G      E             +   
Sbjct: 596 ITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGE-------------KGAQ 642

Query: 228 LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQP 287
           LSGGQ++R+A+A  LV NPPV+  DE TS LD+ S + +   + G  Q   +++   H+ 
Sbjct: 643 LSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQ-KHTVLIIAHRL 701

Query: 288 SAKLFELFDQLYVLSQGQCVYRG 310
           S    E    + VL +G+ V +G
Sbjct: 702 ST--VEHAHLIVVLDKGRVVQQG 722


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.138    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,606,271
Number of Sequences: 37866
Number of extensions: 1013981
Number of successful extensions: 2534
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 2255
Number of HSP's gapped (non-prelim): 177
length of query: 677
length of database: 18,247,518
effective HSP length: 109
effective length of query: 568
effective length of database: 14,120,124
effective search space: 8020230432
effective search space used: 8020230432
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.