Search of human proteins with 46519151

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
         (616 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ...  1209   0.0  
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ...  1201   0.0  
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...  1138   0.0  
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                   1138   0.0  
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   887   0.0  
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   887   0.0  
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   203   4e-52
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        185   1e-46
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       182   1e-45
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        182   1e-45
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        182   1e-45
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        182   1e-45
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        182   1e-45
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       177   3e-44
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        172   8e-43
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        172   8e-43
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   169   5e-42
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   167   2e-41
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...   167   3e-41
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    159   5e-39
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   154   2e-37
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled...   148   1e-35
gi|67906195 ankyrin repeat and sterile alpha motif domain contai...   148   2e-35
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  146   5e-35
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   143   4e-34
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled...   142   7e-34
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled...   142   7e-34
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   142   7e-34
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho...   140   3e-33
gi|89363047 death-associated protein kinase 1 [Homo sapiens]          127   2e-29

>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
           [Homo sapiens]
          Length = 616

 Score = 1209 bits (3129), Expect = 0.0
 Identities = 616/616 (100%), Positives = 616/616 (100%)

Query: 1   MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
           MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG
Sbjct: 1   MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60

Query: 61  GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
           GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT
Sbjct: 61  GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120

Query: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALT 180
           TSEIFLSSTAEGADLRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALT
Sbjct: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALT 180

Query: 181 RMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYY 240
           RMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYY
Sbjct: 181 RMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYY 240

Query: 241 ELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTY 300
           ELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTY
Sbjct: 241 ELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTY 300

Query: 301 ACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF 360
           ACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF
Sbjct: 301 ACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF 360

Query: 361 KESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 420
           KESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV
Sbjct: 361 KESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 420

Query: 421 NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 480
           NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL
Sbjct: 421 NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 480

Query: 481 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELV 540
           AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELV
Sbjct: 481 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELV 540

Query: 541 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDPAK 600
           KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDPAK
Sbjct: 541 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDPAK 600

Query: 601 HQVRVAFDACKLLRKE 616
           HQVRVAFDACKLLRKE
Sbjct: 601 HQVRVAFDACKLLRKE 616


>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
           [Homo sapiens]
          Length = 627

 Score = 1201 bits (3107), Expect = 0.0
 Identities = 616/627 (98%), Positives = 616/627 (98%), Gaps = 11/627 (1%)

Query: 1   MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
           MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG
Sbjct: 1   MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60

Query: 61  GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
           GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT
Sbjct: 61  GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120

Query: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAA-----------AFADPEVLRRLTSSVS 169
           TSEIFLSSTAEGADLRTVDPETQARLEALLEAA           AFADPEVLRRLTSSVS
Sbjct: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180

Query: 170 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 229
           CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES
Sbjct: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240

Query: 230 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 289
           LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS
Sbjct: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300

Query: 290 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 349
           QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH
Sbjct: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360

Query: 350 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 409
           GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV
Sbjct: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420

Query: 410 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 469
           ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR
Sbjct: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480

Query: 470 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 529
           EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM
Sbjct: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540

Query: 530 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDM 589
           EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDM
Sbjct: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDM 600

Query: 590 KTILEGIDPAKHQVRVAFDACKLLRKE 616
           KTILEGIDPAKHQVRVAFDACKLLRKE
Sbjct: 601 KTILEGIDPAKHQVRVAFDACKLLRKE 627


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
           [Homo sapiens]
          Length = 2542

 Score = 1138 bits (2943), Expect = 0.0
 Identities = 590/619 (95%), Positives = 593/619 (95%), Gaps = 12/619 (1%)

Query: 1   MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
           MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG
Sbjct: 1   MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60

Query: 61  GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
           GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT
Sbjct: 61  GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120

Query: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAA-----------AFADPEVLRRLTSSVS 169
           TSEIFLSSTAEGADLRTVDPETQARLEALLEAA           AFADPEVLRRLTSSVS
Sbjct: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180

Query: 170 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 229
           CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES
Sbjct: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240

Query: 230 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 289
           LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS
Sbjct: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300

Query: 290 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 349
           QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH
Sbjct: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360

Query: 350 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 409
           GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV
Sbjct: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420

Query: 410 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 469
           ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR
Sbjct: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480

Query: 470 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 529
           EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM
Sbjct: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540

Query: 530 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQED 588
           EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL+ + E 
Sbjct: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600

Query: 589 MKTILEGIDPAKHQVRVAF 607
            +T L     A H   V F
Sbjct: 601 GRTPLMKAARAGHLCTVQF 619



 Score =  248 bits (632), Expect = 2e-65
 Identities = 149/364 (40%), Positives = 216/364 (59%), Gaps = 10/364 (2%)

Query: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYELAQVLLAMHANVEDR 256
           L EA S G V   R LLD G  +N H+ E  ES L LAC  G+ ++ + LL   A+ E +
Sbjct: 342 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK 401

Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
            ++   T LM A   G++++ +LLL   A VN  + +  + LT A  GG V++  +L+  
Sbjct: 402 TDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460

Query: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376
           GAN+E+ N+ G+TPLMEAA  GH E+  +LL  GA IN  + E +E+ALTLAC  G  ++
Sbjct: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520

Query: 377 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 436
             FL++AGAD E       T LMEA  +GH+E+ + LL SGA V+    + ++ LT A  
Sbjct: 521 ADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577

Query: 437 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 496
            GH ++A +L++ GA+LE  ++ G TPLM+AAR GH   V  L+++GAN+N  T     T
Sbjct: 578 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 637

Query: 497 ALTLACCGGFSEVADFLIKAGAD----IELGCSTPLMEASQEGHLELVKYLLASGANVHA 552
            ++LAC GG   V + L+  GAD    ++ G ST L+EA++ GH  +V YLL    NV +
Sbjct: 638 VVSLACAGGHLAVVELLLAHGADPTHRLKDG-STMLIEAAKGGHTNVVSYLLDYPNNVLS 696

Query: 553 TTAT 556
              T
Sbjct: 697 VPTT 700



 Score =  204 bits (518), Expect = 3e-52
 Identities = 142/443 (32%), Positives = 227/443 (51%), Gaps = 23/443 (5%)

Query: 91   GASGSDEDEVSEVESFILDQEDLDNPVLKTTS--EIFLSSTAEGADLRTVDPETQARLEA 148
            G++G++  E+ +V     +Q+ +  P +  T   +  L    +G  + T        L+ 
Sbjct: 942  GSNGTNSLELQKVSG---NQQIVGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDD 998

Query: 149  LLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENS------------HNAGQVDTR 196
            L+ A +   P      + +  C   E+ +  T   A  S            H     DT 
Sbjct: 999  LIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDT- 1057

Query: 197  SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
            +L  AC+ G    V  L+     +    ++G + L LA +AG+  + ++LL    ++E +
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117

Query: 257  GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
              +   TPL  A SGG  ++V LLL   A+   ++ +  T L+ A +GG+V+I+K+LLN 
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177

Query: 317  GANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 374
            GA I     ++ G +PLM AA  GHV   ++LLD G+ IN      + +ALTLAC++G  
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237

Query: 375  DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLT 432
            ++V  LL+  A+ EH+     T LMEA   G+ EV R+LLD GA VN P    S ++ LT
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297

Query: 433  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492
            +AA  GH +   LLI RGA+++  N +G TPL  A+  GH ++V LL+  GA+++A  + 
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA-ADN 1356

Query: 493  TQETALTLACCGGFSEVADFLIK 515
             + T L  A   G  +V  +L+K
Sbjct: 1357 RKITPLMSAFRKGHVKVVQYLVK 1379



 Score =  191 bits (486), Expect = 1e-48
 Identities = 118/315 (37%), Positives = 178/315 (56%), Gaps = 10/315 (3%)

Query: 284  DADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVA 343
            D D +++S   +TALT ACAGG  ++V VL+   A IE  ++ G TPL+ AA+AGHV V 
Sbjct: 1046 DIDAHTES-NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104

Query: 344  RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 403
             +LLD G  I   S   K++ L+LAC  G  ++V  LL  GA++EH+    +T L  A  
Sbjct: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164

Query: 404  DGHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLE-EVNDEG 460
             G+V + ++LL++GA++N    S    SPL LAA  GHV    LL++ G+++  ++    
Sbjct: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224

Query: 461  YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI 520
             T L  A  +G  E+V+LLL + AN+  +  +T  T L  A  GG++EV   L+  GAD+
Sbjct: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADV 1283

Query: 521  EL-----GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 575
                      T L  A+ +GH +  + L+  GA++      G+T L  A   GH DV  +
Sbjct: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343

Query: 576  LLQAGADLDKQEDMK 590
            L+QAGAD+D  ++ K
Sbjct: 1344 LVQAGADVDAADNRK 1358



 Score =  168 bits (425), Expect = 2e-41
 Identities = 108/286 (37%), Positives = 146/286 (51%), Gaps = 22/286 (7%)

Query: 148 ALLEAAAFADPEVLRRLTSS-----------------VSCALDEAAAALTRMKAENSHNA 190
           AL+EA      EV R L  S                  +C      AAL   +  N    
Sbjct: 408 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEV 467

Query: 191 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG-ESLLCLACSAGYYELAQVLLAM 249
                  L EA  +G    V  LL +G ++N  TEE  E+ L LAC  G+ E+A  L+  
Sbjct: 468 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA 527

Query: 250 HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDI 309
            A++E     G  TPLM AS  G+L++VK LL   A+V++ +ATG+TALTYAC  G  D+
Sbjct: 528 GADIE----LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 583

Query: 310 VKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLAC 369
             VLL  GA++E  +E G TPLM+AA AGH+   + L+  GA +N  +     + ++LAC
Sbjct: 584 ADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLAC 643

Query: 370 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 415
             GHL +V  LL  GAD  H+  +  T L+EA   GH  V   LLD
Sbjct: 644 AGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689



 Score = 69.7 bits (169), Expect = 7e-12
 Identities = 43/135 (31%), Positives = 63/135 (46%)

Query: 186 NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 245
           N H        +L  AC +G  +    LL  G  +   +E G + L  A  AG+    Q 
Sbjct: 560 NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQF 619

Query: 246 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 305
           L++  ANV       D T +  A +GG+L +V+LLL H AD   +   G+T L  A  GG
Sbjct: 620 LISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGG 679

Query: 306 FVDIVKVLLNEGANI 320
             ++V  LL+   N+
Sbjct: 680 HTNVVSYLLDYPNNV 694


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score = 1138 bits (2943), Expect = 0.0
 Identities = 590/619 (95%), Positives = 593/619 (95%), Gaps = 12/619 (1%)

Query: 1   MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
           MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG
Sbjct: 1   MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60

Query: 61  GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
           GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT
Sbjct: 61  GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120

Query: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAA-----------AFADPEVLRRLTSSVS 169
           TSEIFLSSTAEGADLRTVDPETQARLEALLEAA           AFADPEVLRRLTSSVS
Sbjct: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180

Query: 170 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 229
           CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES
Sbjct: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240

Query: 230 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 289
           LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS
Sbjct: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300

Query: 290 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 349
           QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH
Sbjct: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360

Query: 350 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 409
           GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV
Sbjct: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420

Query: 410 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 469
           ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR
Sbjct: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480

Query: 470 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 529
           EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM
Sbjct: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540

Query: 530 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQED 588
           EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL+ + E 
Sbjct: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600

Query: 589 MKTILEGIDPAKHQVRVAF 607
            +T L     A H   V F
Sbjct: 601 GRTPLMKAARAGHLCTVQF 619



 Score =  248 bits (632), Expect = 2e-65
 Identities = 149/364 (40%), Positives = 216/364 (59%), Gaps = 10/364 (2%)

Query: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYELAQVLLAMHANVEDR 256
           L EA S G V   R LLD G  +N H+ E  ES L LAC  G+ ++ + LL   A+ E +
Sbjct: 342 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK 401

Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
            ++   T LM A   G++++ +LLL   A VN  + +  + LT A  GG V++  +L+  
Sbjct: 402 TDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460

Query: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376
           GAN+E+ N+ G+TPLMEAA  GH E+  +LL  GA IN  + E +E+ALTLAC  G  ++
Sbjct: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520

Query: 377 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 436
             FL++AGAD E       T LMEA  +GH+E+ + LL SGA V+    + ++ LT A  
Sbjct: 521 ADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577

Query: 437 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 496
            GH ++A +L++ GA+LE  ++ G TPLM+AAR GH   V  L+++GAN+N  T     T
Sbjct: 578 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 637

Query: 497 ALTLACCGGFSEVADFLIKAGAD----IELGCSTPLMEASQEGHLELVKYLLASGANVHA 552
            ++LAC GG   V + L+  GAD    ++ G ST L+EA++ GH  +V YLL    NV +
Sbjct: 638 VVSLACAGGHLAVVELLLAHGADPTHRLKDG-STMLIEAAKGGHTNVVSYLLDYPNNVLS 696

Query: 553 TTAT 556
              T
Sbjct: 697 VPTT 700



 Score =  204 bits (518), Expect = 3e-52
 Identities = 142/443 (32%), Positives = 227/443 (51%), Gaps = 23/443 (5%)

Query: 91   GASGSDEDEVSEVESFILDQEDLDNPVLKTTS--EIFLSSTAEGADLRTVDPETQARLEA 148
            G++G++  E+ +V     +Q+ +  P +  T   +  L    +G  + T        L+ 
Sbjct: 942  GSNGTNSLELQKVSG---NQQIVGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDD 998

Query: 149  LLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENS------------HNAGQVDTR 196
            L+ A +   P      + +  C   E+ +  T   A  S            H     DT 
Sbjct: 999  LIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDT- 1057

Query: 197  SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
            +L  AC+ G    V  L+     +    ++G + L LA +AG+  + ++LL    ++E +
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117

Query: 257  GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
              +   TPL  A SGG  ++V LLL   A+   ++ +  T L+ A +GG+V+I+K+LLN 
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177

Query: 317  GANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 374
            GA I     ++ G +PLM AA  GHV   ++LLD G+ IN      + +ALTLAC++G  
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237

Query: 375  DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLT 432
            ++V  LL+  A+ EH+     T LMEA   G+ EV R+LLD GA VN P    S ++ LT
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297

Query: 433  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492
            +AA  GH +   LLI RGA+++  N +G TPL  A+  GH ++V LL+  GA+++A  + 
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA-ADN 1356

Query: 493  TQETALTLACCGGFSEVADFLIK 515
             + T L  A   G  +V  +L+K
Sbjct: 1357 RKITPLMSAFRKGHVKVVQYLVK 1379



 Score =  191 bits (486), Expect = 1e-48
 Identities = 118/315 (37%), Positives = 178/315 (56%), Gaps = 10/315 (3%)

Query: 284  DADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVA 343
            D D +++S   +TALT ACAGG  ++V VL+   A IE  ++ G TPL+ AA+AGHV V 
Sbjct: 1046 DIDAHTES-NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104

Query: 344  RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 403
             +LLD G  I   S   K++ L+LAC  G  ++V  LL  GA++EH+    +T L  A  
Sbjct: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164

Query: 404  DGHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLE-EVNDEG 460
             G+V + ++LL++GA++N    S    SPL LAA  GHV    LL++ G+++  ++    
Sbjct: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224

Query: 461  YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI 520
             T L  A  +G  E+V+LLL + AN+  +  +T  T L  A  GG++EV   L+  GAD+
Sbjct: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADV 1283

Query: 521  EL-----GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 575
                      T L  A+ +GH +  + L+  GA++      G+T L  A   GH DV  +
Sbjct: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343

Query: 576  LLQAGADLDKQEDMK 590
            L+QAGAD+D  ++ K
Sbjct: 1344 LVQAGADVDAADNRK 1358



 Score =  168 bits (425), Expect = 2e-41
 Identities = 108/286 (37%), Positives = 146/286 (51%), Gaps = 22/286 (7%)

Query: 148 ALLEAAAFADPEVLRRLTSS-----------------VSCALDEAAAALTRMKAENSHNA 190
           AL+EA      EV R L  S                  +C      AAL   +  N    
Sbjct: 408 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEV 467

Query: 191 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG-ESLLCLACSAGYYELAQVLLAM 249
                  L EA  +G    V  LL +G ++N  TEE  E+ L LAC  G+ E+A  L+  
Sbjct: 468 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA 527

Query: 250 HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDI 309
            A++E     G  TPLM AS  G+L++VK LL   A+V++ +ATG+TALTYAC  G  D+
Sbjct: 528 GADIE----LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 583

Query: 310 VKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLAC 369
             VLL  GA++E  +E G TPLM+AA AGH+   + L+  GA +N  +     + ++LAC
Sbjct: 584 ADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLAC 643

Query: 370 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 415
             GHL +V  LL  GAD  H+  +  T L+EA   GH  V   LLD
Sbjct: 644 AGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689



 Score = 69.7 bits (169), Expect = 7e-12
 Identities = 43/135 (31%), Positives = 63/135 (46%)

Query: 186 NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 245
           N H        +L  AC +G  +    LL  G  +   +E G + L  A  AG+    Q 
Sbjct: 560 NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQF 619

Query: 246 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 305
           L++  ANV       D T +  A +GG+L +V+LLL H AD   +   G+T L  A  GG
Sbjct: 620 LISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGG 679

Query: 306 FVDIVKVLLNEGANI 320
             ++V  LL+   N+
Sbjct: 680 HTNVVSYLLDYPNNV 694


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
           sapiens]
          Length = 2603

 Score =  887 bits (2293), Expect = 0.0
 Identities = 468/586 (79%), Positives = 505/586 (86%), Gaps = 35/586 (5%)

Query: 42  RTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDE-- 99
           RT R    +  +S   +SGGGG G G GGG               GGG  ++ S+E+E  
Sbjct: 78  RTCRPPSSSESSSDSDNSGGGGGGGGGGGG---------------GGGTSSNNSEEEEDD 122

Query: 100 ------VSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAA 153
                 VSEVESFILDQ+DL+NP+L+T S++ LS TA+GADLRTVDPETQARLEALLEAA
Sbjct: 123 DDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAA 182

Query: 154 -----------AFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEAC 202
                      AFADPEVLRRLTSSVSCALDEAAAALTRM+AE++ NAGQ D RSLAEAC
Sbjct: 183 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 242

Query: 203 SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 262
           S+GDVNAVRKLL EGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG KGDI
Sbjct: 243 SEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDI 302

Query: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
           TPLMAA++GG++ IVKLLL H ADVN+QS+TGNTALTYACAGG+VD+VKVLL  GA+IED
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362

Query: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382
           HNENGHTPLMEA SAGHVEVAR+LL++GAGINTHSNEFKESALTLACYKGHL+MVRFLLE
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422

Query: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 442
           AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482

Query: 443 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 502
           AALLIERGA+LEEVNDEGYTPLMEAAREGHEEMVALLL QGANINAQTEETQETALTLAC
Sbjct: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542

Query: 503 CGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 562
           CGGF EVADFLIKAGADIELGCSTPLMEA+QEGHLELVKYLLA+GANVHATTATGDTALT
Sbjct: 543 CGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALT 602

Query: 563 YACENGHTDVADVLLQAGADLD-KQEDMKTILEGIDPAKHQVRVAF 607
           YACENGHTDVADVLLQAGADL+ + E  +T L     A H   V F
Sbjct: 603 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQF 648



 Score =  246 bits (628), Expect = 4e-65
 Identities = 150/370 (40%), Positives = 219/370 (59%), Gaps = 10/370 (2%)

Query: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYELAQVLLAMHANVEDR 256
           L EA S G V   R LL+ G  +N H+ E  ES L LAC  G+ E+ + LL   A+ E +
Sbjct: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHK 430

Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
            ++   T LM A   G++++ +LLL   A VN  + +  + LT A  GG V++  +L+  
Sbjct: 431 TDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 489

Query: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376
           GA++E+ N+ G+TPLMEAA  GH E+  +LL  GA IN  + E +E+ALTLAC  G L++
Sbjct: 490 GASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEV 549

Query: 377 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 436
             FL++AGAD E       T LMEA  +GH+E+ + LL +GA V+    + ++ LT A  
Sbjct: 550 ADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACE 606

Query: 437 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 496
            GH ++A +L++ GA+LE  ++ G TPLM+AAR GH   V  L+++GAN+N  T     T
Sbjct: 607 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHT 666

Query: 497 ALTLACCGGFSEVADFLIKAGAD----IELGCSTPLMEASQEGHLELVKYLLASGANVHA 552
            L+LAC GG   V + L+  GAD    ++ G ST L+EA++ GH  +V YLL    N+ +
Sbjct: 667 VLSLACAGGHLAVVELLLAHGADPTHRLKDG-STMLIEAAKGGHTSVVCYLLDYPNNLLS 725

Query: 553 TTATGDTALT 562
                 T LT
Sbjct: 726 APPPDVTQLT 735



 Score =  207 bits (526), Expect = 3e-53
 Identities = 127/352 (36%), Positives = 195/352 (55%), Gaps = 35/352 (9%)

Query: 197  SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
            +L  AC+ G    V+ LL+ G S+    ++G + L LA +AG+  + ++LL   A++E +
Sbjct: 1086 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 1145

Query: 257  GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
              +   TPL  A SGG  ++V+LLL   A+   ++ +  T L+ A +GG+V+I+K+LLN 
Sbjct: 1146 SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1205

Query: 317  GANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 374
            GA I     ++ G +PLM AA  GH    ++LLD G+ IN      + +ALTLAC++G  
Sbjct: 1206 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1265

Query: 375  DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLT 432
            ++V  LL+  A+ EH+     T LMEA   G+ EV R+LLD GA VN P    S ++ LT
Sbjct: 1266 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1325

Query: 433  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492
            +AA  GH +   LLI RGA+++  N +G TPL  AA  GH ++V LL+  GA+++A    
Sbjct: 1326 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1385

Query: 493  TQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 544
                                             TPLM A ++GH+++V+YL+
Sbjct: 1386 K-------------------------------ITPLMAAFRKGHVKVVRYLV 1406



 Score =  198 bits (503), Expect = 1e-50
 Identities = 118/314 (37%), Positives = 182/314 (57%), Gaps = 10/314 (3%)

Query: 286  DVNSQSATGN-TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 344
            D+++Q+ + + TALT ACAGG  ++V+ LL  GA+IE  ++ G TPL+ AA+AGHV V  
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133

Query: 345  VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 404
            +LLD+GA I   S   K++ L+LAC  G  ++V  LL  GA++EH+    +T L  A   
Sbjct: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193

Query: 405  GHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLE-EVNDEGY 461
            G+V + ++LL++GA++N    S    SPL LAA  GH     LL++ G+++  ++     
Sbjct: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1253

Query: 462  TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIE 521
            T L  A  +G  E+V+LLL + AN+  +  +T  T L  A  GG++EV   L+  GAD+ 
Sbjct: 1254 TALTLACFQGRTEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADVN 1312

Query: 522  L-----GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 576
                     T L  A+ +GH +  + L+  GA++      G+T L  A   GH DV  +L
Sbjct: 1313 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1372

Query: 577  LQAGADLDKQEDMK 590
            +QAGAD+D  ++ K
Sbjct: 1373 VQAGADVDAADNRK 1386



 Score =  173 bits (439), Expect = 4e-43
 Identities = 118/324 (36%), Positives = 179/324 (55%), Gaps = 9/324 (2%)

Query: 263  TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
            T L  A +GG+ ++V+ LL   A +  +   G T L  A   G V +V++LL+ GA+IE 
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144

Query: 323  HNE-NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 381
             +E    TPL  A S G  EV  +LL  GA    H N    + L+LA   G++++++ LL
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGAN-KEHRNVSDYTPLSLAASGGYVNIIKILL 1203

Query: 382  EAGADQEHKTDEM--HTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGG 438
             AGA+   +T      + LM A M+GH    +LLLD G+ +N   + +  + LTLA   G
Sbjct: 1204 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1263

Query: 439  HVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA-QTEETQETA 497
              E+ +LL++R AN+E     G TPLMEAA  G+ E+  +LL +GA++NA     +++TA
Sbjct: 1264 RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1323

Query: 498  LTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATT 554
            LT+A   G  +  + LI  GA I++     +TPL  A+  GHL++V+ L+ +GA+V A  
Sbjct: 1324 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAAD 1383

Query: 555  ATGDTALTYACENGHTDVADVLLQ 578
                T L  A   GH  V   L++
Sbjct: 1384 NRKITPLMAAFRKGHVKVVRYLVK 1407



 Score =  167 bits (422), Expect = 3e-41
 Identities = 108/286 (37%), Positives = 146/286 (51%), Gaps = 22/286 (7%)

Query: 148 ALLEAAAFADPEVLRRLTSS-----------------VSCALDEAAAALTRMKAENSHNA 190
           AL+EA      EV R L  S                  +C      AAL   +  +    
Sbjct: 437 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEV 496

Query: 191 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG-ESLLCLACSAGYYELAQVLLAM 249
                  L EA  +G    V  LL +G ++N  TEE  E+ L LAC  G+ E+A  L+  
Sbjct: 497 NDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKA 556

Query: 250 HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDI 309
            A++E     G  TPLM A+  G+L++VK LL   A+V++ +ATG+TALTYAC  G  D+
Sbjct: 557 GADIE----LGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDV 612

Query: 310 VKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLAC 369
             VLL  GA++E  +E G TPLM+AA AGHV   + L+  GA +N  +     + L+LAC
Sbjct: 613 ADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLAC 672

Query: 370 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 415
             GHL +V  LL  GAD  H+  +  T L+EA   GH  V   LLD
Sbjct: 673 AGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 44/135 (32%), Positives = 62/135 (45%)

Query: 186 NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 245
           N H        +L  AC +G  +    LL  G  +   +E G + L  A  AG+    Q 
Sbjct: 589 NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQF 648

Query: 246 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 305
           L++  ANV       D T L  A +GG+L +V+LLL H AD   +   G+T L  A  GG
Sbjct: 649 LISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGG 708

Query: 306 FVDIVKVLLNEGANI 320
              +V  LL+   N+
Sbjct: 709 HTSVVCYLLDYPNNL 723


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
           sapiens]
          Length = 2352

 Score =  887 bits (2293), Expect = 0.0
 Identities = 468/586 (79%), Positives = 505/586 (86%), Gaps = 35/586 (5%)

Query: 42  RTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDE-- 99
           RT R    +  +S   +SGGGG G G GGG               GGG  ++ S+E+E  
Sbjct: 78  RTCRPPSSSESSSDSDNSGGGGGGGGGGGG---------------GGGTSSNNSEEEEDD 122

Query: 100 ------VSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAA 153
                 VSEVESFILDQ+DL+NP+L+T S++ LS TA+GADLRTVDPETQARLEALLEAA
Sbjct: 123 DDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAA 182

Query: 154 -----------AFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEAC 202
                      AFADPEVLRRLTSSVSCALDEAAAALTRM+AE++ NAGQ D RSLAEAC
Sbjct: 183 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 242

Query: 203 SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 262
           S+GDVNAVRKLL EGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG KGDI
Sbjct: 243 SEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDI 302

Query: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
           TPLMAA++GG++ IVKLLL H ADVN+QS+TGNTALTYACAGG+VD+VKVLL  GA+IED
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362

Query: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382
           HNENGHTPLMEA SAGHVEVAR+LL++GAGINTHSNEFKESALTLACYKGHL+MVRFLLE
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422

Query: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 442
           AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482

Query: 443 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 502
           AALLIERGA+LEEVNDEGYTPLMEAAREGHEEMVALLL QGANINAQTEETQETALTLAC
Sbjct: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542

Query: 503 CGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 562
           CGGF EVADFLIKAGADIELGCSTPLMEA+QEGHLELVKYLLA+GANVHATTATGDTALT
Sbjct: 543 CGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALT 602

Query: 563 YACENGHTDVADVLLQAGADLD-KQEDMKTILEGIDPAKHQVRVAF 607
           YACENGHTDVADVLLQAGADL+ + E  +T L     A H   V F
Sbjct: 603 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQF 648



 Score =  246 bits (628), Expect = 4e-65
 Identities = 150/370 (40%), Positives = 219/370 (59%), Gaps = 10/370 (2%)

Query: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYELAQVLLAMHANVEDR 256
           L EA S G V   R LL+ G  +N H+ E  ES L LAC  G+ E+ + LL   A+ E +
Sbjct: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHK 430

Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
            ++   T LM A   G++++ +LLL   A VN  + +  + LT A  GG V++  +L+  
Sbjct: 431 TDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 489

Query: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376
           GA++E+ N+ G+TPLMEAA  GH E+  +LL  GA IN  + E +E+ALTLAC  G L++
Sbjct: 490 GASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEV 549

Query: 377 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 436
             FL++AGAD E       T LMEA  +GH+E+ + LL +GA V+    + ++ LT A  
Sbjct: 550 ADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACE 606

Query: 437 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 496
            GH ++A +L++ GA+LE  ++ G TPLM+AAR GH   V  L+++GAN+N  T     T
Sbjct: 607 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHT 666

Query: 497 ALTLACCGGFSEVADFLIKAGAD----IELGCSTPLMEASQEGHLELVKYLLASGANVHA 552
            L+LAC GG   V + L+  GAD    ++ G ST L+EA++ GH  +V YLL    N+ +
Sbjct: 667 VLSLACAGGHLAVVELLLAHGADPTHRLKDG-STMLIEAAKGGHTSVVCYLLDYPNNLLS 725

Query: 553 TTATGDTALT 562
                 T LT
Sbjct: 726 APPPDVTQLT 735



 Score =  207 bits (526), Expect = 3e-53
 Identities = 127/352 (36%), Positives = 195/352 (55%), Gaps = 35/352 (9%)

Query: 197  SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
            +L  AC+ G    V+ LL+ G S+    ++G + L LA +AG+  + ++LL   A++E +
Sbjct: 835  ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 894

Query: 257  GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
              +   TPL  A SGG  ++V+LLL   A+   ++ +  T L+ A +GG+V+I+K+LLN 
Sbjct: 895  SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 954

Query: 317  GANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 374
            GA I     ++ G +PLM AA  GH    ++LLD G+ IN      + +ALTLAC++G  
Sbjct: 955  GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1014

Query: 375  DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLT 432
            ++V  LL+  A+ EH+     T LMEA   G+ EV R+LLD GA VN P    S ++ LT
Sbjct: 1015 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1074

Query: 433  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492
            +AA  GH +   LLI RGA+++  N +G TPL  AA  GH ++V LL+  GA+++A    
Sbjct: 1075 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1134

Query: 493  TQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 544
                                             TPLM A ++GH+++V+YL+
Sbjct: 1135 K-------------------------------ITPLMAAFRKGHVKVVRYLV 1155



 Score =  198 bits (503), Expect = 1e-50
 Identities = 118/314 (37%), Positives = 182/314 (57%), Gaps = 10/314 (3%)

Query: 286  DVNSQSATGN-TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 344
            D+++Q+ + + TALT ACAGG  ++V+ LL  GA+IE  ++ G TPL+ AA+AGHV V  
Sbjct: 823  DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 882

Query: 345  VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 404
            +LLD+GA I   S   K++ L+LAC  G  ++V  LL  GA++EH+    +T L  A   
Sbjct: 883  ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 942

Query: 405  GHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLE-EVNDEGY 461
            G+V + ++LL++GA++N    S    SPL LAA  GH     LL++ G+++  ++     
Sbjct: 943  GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1002

Query: 462  TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIE 521
            T L  A  +G  E+V+LLL + AN+  +  +T  T L  A  GG++EV   L+  GAD+ 
Sbjct: 1003 TALTLACFQGRTEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADVN 1061

Query: 522  L-----GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 576
                     T L  A+ +GH +  + L+  GA++      G+T L  A   GH DV  +L
Sbjct: 1062 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1121

Query: 577  LQAGADLDKQEDMK 590
            +QAGAD+D  ++ K
Sbjct: 1122 VQAGADVDAADNRK 1135



 Score =  173 bits (439), Expect = 4e-43
 Identities = 118/324 (36%), Positives = 179/324 (55%), Gaps = 9/324 (2%)

Query: 263  TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
            T L  A +GG+ ++V+ LL   A +  +   G T L  A   G V +V++LL+ GA+IE 
Sbjct: 834  TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893

Query: 323  HNE-NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 381
             +E    TPL  A S G  EV  +LL  GA    H N    + L+LA   G++++++ LL
Sbjct: 894  QSERTKDTPLSLACSGGRQEVVELLLARGAN-KEHRNVSDYTPLSLAASGGYVNIIKILL 952

Query: 382  EAGADQEHKTDEM--HTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGG 438
             AGA+   +T      + LM A M+GH    +LLLD G+ +N   + +  + LTLA   G
Sbjct: 953  NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1012

Query: 439  HVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA-QTEETQETA 497
              E+ +LL++R AN+E     G TPLMEAA  G+ E+  +LL +GA++NA     +++TA
Sbjct: 1013 RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1072

Query: 498  LTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATT 554
            LT+A   G  +  + LI  GA I++     +TPL  A+  GHL++V+ L+ +GA+V A  
Sbjct: 1073 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAAD 1132

Query: 555  ATGDTALTYACENGHTDVADVLLQ 578
                T L  A   GH  V   L++
Sbjct: 1133 NRKITPLMAAFRKGHVKVVRYLVK 1156



 Score =  167 bits (422), Expect = 3e-41
 Identities = 108/286 (37%), Positives = 146/286 (51%), Gaps = 22/286 (7%)

Query: 148 ALLEAAAFADPEVLRRLTSS-----------------VSCALDEAAAALTRMKAENSHNA 190
           AL+EA      EV R L  S                  +C      AAL   +  +    
Sbjct: 437 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEV 496

Query: 191 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG-ESLLCLACSAGYYELAQVLLAM 249
                  L EA  +G    V  LL +G ++N  TEE  E+ L LAC  G+ E+A  L+  
Sbjct: 497 NDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKA 556

Query: 250 HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDI 309
            A++E     G  TPLM A+  G+L++VK LL   A+V++ +ATG+TALTYAC  G  D+
Sbjct: 557 GADIE----LGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDV 612

Query: 310 VKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLAC 369
             VLL  GA++E  +E G TPLM+AA AGHV   + L+  GA +N  +     + L+LAC
Sbjct: 613 ADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLAC 672

Query: 370 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 415
             GHL +V  LL  GAD  H+  +  T L+EA   GH  V   LLD
Sbjct: 673 AGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 44/135 (32%), Positives = 62/135 (45%)

Query: 186 NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 245
           N H        +L  AC +G  +    LL  G  +   +E G + L  A  AG+    Q 
Sbjct: 589 NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQF 648

Query: 246 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 305
           L++  ANV       D T L  A +GG+L +V+LLL H AD   +   G+T L  A  GG
Sbjct: 649 LISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGG 708

Query: 306 FVDIVKVLLNEGANI 320
              +V  LL+   N+
Sbjct: 709 HTSVVCYLLDYPNNL 723


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  203 bits (516), Expect = 4e-52
 Identities = 146/462 (31%), Positives = 234/462 (50%), Gaps = 20/462 (4%)

Query: 123  EIFLSSTAEGADLRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRM 182
            +I L+    GA++   D E +    AL+ AA     E++  L       LD  A     +
Sbjct: 658  DIVLNLLQHGAEVNKADNEGRT---ALIAAAYMGHREIVEHL-------LDHGA----EV 703

Query: 183  KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 242
              E+      +   +L    S G  + V  L+D G  V+   ++G + L +A   G+ ++
Sbjct: 704  NHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDV 763

Query: 243  AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 302
              +LL   A+V+   N G  TPL+AA+S G+  +V  LL   A V+S  + G T L+ A 
Sbjct: 764  VDLLLEGGADVDHTDNNGR-TPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIAS 822

Query: 303  AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE 362
            A G V++V+ LL+ G +    ++ G TPL  AA  GH  +   L++ GA  N   N+ + 
Sbjct: 823  AQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRI 882

Query: 363  SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 422
              + LA  +GH D V+ LLE  ++ + +  +   AL  A ++GH ++  LL   GA VN 
Sbjct: 883  PFI-LASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNC 941

Query: 423  PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
                    L + A    + +A   +E GAN+E  + EG T L  +  +GH EMV +L+A 
Sbjct: 942  KDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAY 1001

Query: 483  GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLEL 539
             A++NA   E + +AL  A   G  +V   LI+ GA ++  C+   T L  A+QEGH+++
Sbjct: 1002 HADVNAADNE-KRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDV 1060

Query: 540  VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 581
            V+ LL  GA+ +     G TA+  A +NGH+ +  +L + GA
Sbjct: 1061 VQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102



 Score =  196 bits (498), Expect = 5e-50
 Identities = 133/434 (30%), Positives = 211/434 (48%), Gaps = 41/434 (9%)

Query: 189  NAGQVDTRSLAEACS-DGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 247
            +    D+R+   A +  G  + V  LL  G  VN+   EG + L  A   G+ E+ + LL
Sbjct: 638  DCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLL 697

Query: 248  AMHANVEDRGNKG----DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACA 303
               A V      G     +  L   +S G+  +V LL+   A+V+     G T L  A  
Sbjct: 698  DHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAY 757

Query: 304  GGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKES 363
             G VD+V +LL  GA+++  + NG TPL+ AAS GH  V   LL  GA +++  +E + +
Sbjct: 758  EGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR-T 816

Query: 364  ALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP 423
             L++A  +G++++VR LL+ G D+ H+ D   T L  A  +GH  +   L++ GA+ N  
Sbjct: 817  VLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEI 876

Query: 424  ADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG 483
             +    P  LA+  GH +   +L+E  +N+++   +G   L  AA EGH ++V LL + G
Sbjct: 877  DNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHG 936

Query: 484  ANINAQTEETQ--------------------------------ETALTLACCGGFSEVAD 511
            A++N +  + +                                 TAL ++C  G  E+  
Sbjct: 937  ADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQ 996

Query: 512  FLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENG 568
             LI   AD+    +   + L  A+ +GH+++V+ L+  GA V  T   G TAL  A + G
Sbjct: 997  VLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEG 1056

Query: 569  HTDVADVLLQAGAD 582
            H DV  VLL+ GAD
Sbjct: 1057 HIDVVQVLLEHGAD 1070



 Score =  196 bits (497), Expect = 7e-50
 Identities = 155/532 (29%), Positives = 237/532 (44%), Gaps = 81/532 (15%)

Query: 135  LRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVD 194
            L T+ P+ Q  L+ L++A A  + E   R +  V  AL+   +  T +  +N  +  Q D
Sbjct: 486  LSTLIPKEQEVLQLLVKAGAHVNSED-DRTSCIVRQALEREDSIRTLL--DNGASVNQCD 542

Query: 195  TRS---LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 251
            +     LA A   G ++ V  L+  G  +      G + L LA   G+ ++   L+   A
Sbjct: 543  SNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGA 602

Query: 252  NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 311
            N+      G  T L +A+ GG+ ++V  LL     V+   A   TAL  A  GG  DIV 
Sbjct: 603  NINHTDQDG-WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVL 661

Query: 312  VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN----------------- 354
             LL  GA +   +  G T L+ AA  GH E+   LLDHGA +N                 
Sbjct: 662  NLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCV 721

Query: 355  --------------------THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEM 394
                                 H ++   + L +A Y+GH+D+V  LLE GAD +H  +  
Sbjct: 722  PASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNG 781

Query: 395  HTALMEACMDGH---------------------------------VEVARLLLDSGAQVN 421
             T L+ A   GH                                 VEV R LLD G   N
Sbjct: 782  RTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDEN 841

Query: 422  MPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA 481
               D+  +PL +AA  GH  +   LIE+GA   E++++G  P + A++EGH + V +LL 
Sbjct: 842  HRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLE 901

Query: 482  QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLE 538
              +NI+ +  + +  AL +A   G  ++ + L   GAD+   +      L   + E  L 
Sbjct: 902  NKSNIDQRGYDGRN-ALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLT 960

Query: 539  LVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 590
            + +Y L +GANV A+ A G TAL  +C  GH ++  VL+   AD++  ++ K
Sbjct: 961  MAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEK 1012



 Score =  157 bits (397), Expect = 3e-38
 Identities = 109/339 (32%), Positives = 169/339 (49%), Gaps = 12/339 (3%)

Query: 275 DIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 334
           ++++LL+   A VNS+    +  +  A      D ++ LL+ GA++   + NG T L  A
Sbjct: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSNGRTLLANA 552

Query: 335 ASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEM 394
           A +G ++V  +L+  GA +    +    + LTLA  +GH  +V  L+  GA+  H   + 
Sbjct: 553 AYSGSLDVVNLLVSRGADLEIE-DAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611

Query: 395 HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLE 454
            TAL  A   GH EV   LL +G +V+       + L  AA GGH ++   L++ GA + 
Sbjct: 612 WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671

Query: 455 EVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACC----GGFSEVA 510
           + ++EG T L+ AA  GH E+V  LL  GA +N +  + +      A C     G + V 
Sbjct: 672 KADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVV 731

Query: 511 DFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 566
             LI  GA+++  C     TPL+ A+ EGH+++V  LL  GA+V  T   G T L  A  
Sbjct: 732 SLLIDRGAEVD-HCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAAS 790

Query: 567 NGHTDVADVLLQAGADLDKQEDMKTILEGIDPAKHQVRV 605
            GH  V + LL  GA +D  +     +  I  A+  V V
Sbjct: 791 MGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEV 829



 Score =  155 bits (393), Expect = 8e-38
 Identities = 114/364 (31%), Positives = 176/364 (48%), Gaps = 6/364 (1%)

Query: 198  LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257
            L  A S G  + V  LL  G +V+    EG ++L +A + G  E+ + LL    +   R 
Sbjct: 785  LLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRD 844

Query: 258  NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
            + G  TPL  A+  G+  I + L+   A  N     G      A   G  D V++LL   
Sbjct: 845  DAG-WTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENK 903

Query: 318  ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377
            +NI+    +G   L  AA  GH ++  +L  HGA +N    + + +   LA  +  L M 
Sbjct: 904  SNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILAL-ENQLTMA 962

Query: 378  RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 437
             + LE GA+ E    E  TAL  +C  GH+E+ ++L+   A VN   +   S L  AA  
Sbjct: 963  EYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQ 1022

Query: 438  GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 497
            GHV++  LLIE GA ++   ++G T L  AA+EGH ++V +LL  GA+ N   ++   TA
Sbjct: 1023 GHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPN-HADQFGRTA 1081

Query: 498  LTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLAS---GANVHATT 554
            + +A   G S++   L K GA    GCS   +   ++  L+ +   + S    +N   +T
Sbjct: 1082 MRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGST 1141

Query: 555  ATGD 558
              GD
Sbjct: 1142 GGGD 1145


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  185 bits (469), Expect = 1e-46
 Identities = 132/395 (33%), Positives = 200/395 (50%), Gaps = 12/395 (3%)

Query: 194 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 253
           D   L  A   G+ N V+ LLD G  ++  T +G + L     +G+ ++ ++LL   A +
Sbjct: 268 DITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI 327

Query: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
             +   G ++PL  A+ G +L+ V+LLL H+  V+  +    TAL  A   G   + KVL
Sbjct: 328 LSKTKNG-LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386

Query: 314 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACY 370
           L++ AN      NG TPL  A     ++V  +LL HGA I   +    ES LT   +A +
Sbjct: 387 LDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT----ESGLTPIHVAAF 442

Query: 371 KGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 430
            GH+++V  L+  GA          TAL  A   G  EV R L+  GAQV   A   ++P
Sbjct: 443 MGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 502

Query: 431 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 490
           L ++A  G  ++   L+++GA+       GYTPL  +AREGHE++ A LL  GA+++  T
Sbjct: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT 562

Query: 491 EETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASG 547
           ++   T L +A   G  EVA+ L++  A  +       TPL  A+   + ++   LL  G
Sbjct: 563 KK-GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQG 621

Query: 548 ANVHATTATGDTALTYACENGHTDVADVLLQAGAD 582
           A+ HA    G T L  A +    D+A  LL+ GAD
Sbjct: 622 ASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGAD 656



 Score =  181 bits (459), Expect = 2e-45
 Identities = 136/427 (31%), Positives = 216/427 (50%), Gaps = 19/427 (4%)

Query: 168 VSCALDEAAAALTRMKAENS--HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE 225
           V   LD AA  L++ K   S  H A Q D            +N V+ LL     V++ T 
Sbjct: 317 VEMLLDRAAPILSKTKNGLSPLHMATQGD-----------HLNCVQLLLQHNVPVDDVTN 365

Query: 226 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 285
           +  + L +A   G+Y++A+VLL   AN   +   G  TPL  A     + +++LLL H A
Sbjct: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNG-FTPLHIACKKNRIKVMELLLKHGA 424

Query: 286 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 345
            + + + +G T +  A   G V+IV  L++ GA+    N  G T L  AA +G  EV R 
Sbjct: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484

Query: 346 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 405
           L+  GA +   + +  ++ L ++   G  D+V+ LL+ GA     T   +T L  +  +G
Sbjct: 485 LVQDGAQVEAKAKD-DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG 543

Query: 406 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 465
           H +VA  LLD GA +++      +PL +AA  G +E+A LL+++ A+ +     G TPL 
Sbjct: 544 HEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLH 603

Query: 466 EAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS 525
            AA   ++++  LLL QGA+ +A  +    T L +A      ++A  L++ GAD      
Sbjct: 604 VAAHYDNQKVALLLLDQGASPHAAAKNGY-TPLHIAAKKNQMDIATTLLEYGADANAVTR 662

Query: 526 TPLME---ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 582
             +     A+QEGH+++V  LL   ANV+ +  +G T L  A +    +VA+VL+  GA 
Sbjct: 663 QGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAH 722

Query: 583 LDKQEDM 589
           +D Q  M
Sbjct: 723 VDAQTKM 729



 Score =  171 bits (432), Expect = 2e-42
 Identities = 133/426 (31%), Positives = 208/426 (48%), Gaps = 7/426 (1%)

Query: 159 EVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGR 218
           + L  L  +  C   + A  L   KA  +  A    T  L  AC    +  +  LL  G 
Sbjct: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFT-PLHIACKKNRIKVMELLLKHGA 424

Query: 219 SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVK 278
           S+   TE G + + +A   G+  +   L+   A+      +G+    MAA SG   ++V+
Sbjct: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSG-QAEVVR 483

Query: 279 LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAG 338
            L+   A V +++    T L  +   G  DIV+ LL +GA+      +G+TPL  +A  G
Sbjct: 484 YLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG 543

Query: 339 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 398
           H +VA  LLDHGA ++  + +   + L +A   G L++   LL+  A  +       T L
Sbjct: 544 HEDVAAFLLDHGASLSITTKK-GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPL 602

Query: 399 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 458
             A    + +VA LLLD GA  +  A +  +PL +AA    +++A  L+E GA+   V  
Sbjct: 603 HVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTR 662

Query: 459 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 518
           +G   +  AA+EGH +MV+LLL + AN+N  + ++  T L LA       VA+ L+  GA
Sbjct: 663 QGIASVHLAAQEGHVDMVSLLLGRNANVNL-SNKSGLTPLHLAAQEDRVNVAEVLVNQGA 721

Query: 519 DIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 575
            ++       TPL      G++++V +LL   A V+A T  G T L  A + GHT + +V
Sbjct: 722 HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINV 781

Query: 576 LLQAGA 581
           LLQ  A
Sbjct: 782 LLQNNA 787



 Score =  170 bits (431), Expect = 3e-42
 Identities = 124/378 (32%), Positives = 188/378 (49%), Gaps = 12/378 (3%)

Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
           G VN V +L+  G S N     GE+ L +A  +G  E+ + L+   A VE +  K D TP
Sbjct: 444 GHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKA-KDDQTP 502

Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
           L  ++  G  DIV+ LL   A  N+ + +G T L  +   G  D+   LL+ GA++    
Sbjct: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT 562

Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD---MVRFLL 381
           + G TPL  AA  G +EVA +LL   A  +       +S LT      H D   +   LL
Sbjct: 563 KKGFTPLHVAAKYGKLEVANLLLQKSASPDAAG----KSGLTPLHVAAHYDNQKVALLLL 618

Query: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
           + GA         +T L  A     +++A  LL+ GA  N       + + LAA  GHV+
Sbjct: 619 DQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVD 678

Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
           + +LL+ R AN+   N  G TPL  AA+E    +  +L+ QGA+++AQT+    T L + 
Sbjct: 679 MVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGY-TPLHVG 737

Query: 502 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 558
           C  G  ++ +FL++  A +        TPL +A+Q+GH  ++  LL + A+ +  T  G+
Sbjct: 738 CHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGN 797

Query: 559 TALTYACENGHTDVADVL 576
           TAL  A   G+  V D L
Sbjct: 798 TALGIARRLGYISVVDTL 815



 Score =  164 bits (415), Expect = 2e-40
 Identities = 119/391 (30%), Positives = 195/391 (49%), Gaps = 6/391 (1%)

Query: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
           +L  A   G     + LLD+  + N     G + L +AC     ++ ++LL   A+++  
Sbjct: 370 ALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAV 429

Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
              G +TP+  A+  G+++IV  L+ H A  N+ +  G TAL  A   G  ++V+ L+ +
Sbjct: 430 TESG-LTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQD 488

Query: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376
           GA +E   ++  TPL  +A  G  ++ + LL  GA  N  +     + L L+  +GH D+
Sbjct: 489 GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTS-GYTPLHLSAREGHEDV 547

Query: 377 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 436
             FLL+ GA     T +  T L  A   G +EVA LLL   A  +    S  +PL +AA 
Sbjct: 548 AAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAH 607

Query: 437 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 496
             + ++A LL+++GA+       GYTPL  AA++   ++   LL  GA+ NA T +    
Sbjct: 608 YDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGI-A 666

Query: 497 ALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHAT 553
           ++ LA   G  ++   L+   A++ L      TPL  A+QE  + + + L+  GA+V A 
Sbjct: 667 SVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQ 726

Query: 554 TATGDTALTYACENGHTDVADVLLQAGADLD 584
           T  G T L   C  G+  + + LLQ  A ++
Sbjct: 727 TKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN 757



 Score =  155 bits (393), Expect = 8e-38
 Identities = 125/429 (29%), Positives = 203/429 (47%), Gaps = 36/429 (8%)

Query: 187 SHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVL 246
           +H A Q+      E  ++ +    RK     R   + ++   S L  A  AG+ E A   
Sbjct: 2   AHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYL-RAARAGHLEKALDY 60

Query: 247 LAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGF 306
           +    ++ +  N+  +  L  AS  G++++V  LL  +A+V++ +  GNTAL  A   G 
Sbjct: 61  IKNGVDI-NICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQ 119

Query: 307 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 366
            ++VKVL+  GAN+   ++NG TPL  AA   H+EV + LLD+GA   + + E   + L 
Sbjct: 120 AEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS-QSLATEDGFTPLA 178

Query: 367 LACYKGHLDMVRFLLEAGADQEHKTDEMH-----------------------------TA 397
           +A  +GH  +V  LLE     + +   +H                             T 
Sbjct: 179 VALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTP 238

Query: 398 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN 457
           L  A   G++ VA LLL+  A V+  A +  +PL +A+  G+  +  LL++RGA ++   
Sbjct: 239 LHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKT 298

Query: 458 DEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAG 517
            +G TPL   AR GHE++V +LL + A I ++T+    + L +A  G        L++  
Sbjct: 299 RDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGL-SPLHMATQGDHLNCVQLLLQHN 357

Query: 518 A---DIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVAD 574
               D+     T L  A+  GH ++ K LL   AN +A    G T L  AC+     V +
Sbjct: 358 VPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVME 417

Query: 575 VLLQAGADL 583
           +LL+ GA +
Sbjct: 418 LLLKHGASI 426



 Score =  138 bits (347), Expect = 2e-32
 Identities = 107/337 (31%), Positives = 168/337 (49%), Gaps = 16/337 (4%)

Query: 255 DRGNKGDITP-LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
           DR  K D     + A+  G+L+     + +  D+N  +  G  AL  A   G V++V  L
Sbjct: 34  DRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSEL 93

Query: 314 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS-NEFKESALTLACYKG 372
           L   AN++   + G+T L  A+ AG  EV +VL+ +GA +N  S N F  + L +A  + 
Sbjct: 94  LQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGF--TPLYMAAQEN 151

Query: 373 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL--DSGAQVNMPADSFESP 430
           HL++V+FLL+ GA Q   T++  T L  A   GH +V  LLL  D+  +V +PA      
Sbjct: 152 HLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPA------ 205

Query: 431 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 490
           L +AA     + AALL++   N +  +  G+TPL  AA  G+  +  LLL + A ++  T
Sbjct: 206 LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDF-T 264

Query: 491 EETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASG 547
                T L +A   G + +   L+  GA I+       TPL   ++ GH ++V+ LL   
Sbjct: 265 ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324

Query: 548 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
           A + + T  G + L  A +  H +   +LLQ    +D
Sbjct: 325 APILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVD 361



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 37/93 (39%), Positives = 50/93 (53%), Gaps = 6/93 (6%)

Query: 498 LTLACCGGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGANVHAT 553
           L  A  G   +  D+ IK G DI + C+      L  AS+EGH+E+V  LL   ANV A 
Sbjct: 46  LRAARAGHLEKALDY-IKNGVDINI-CNQNGLNALHLASKEGHVEVVSELLQREANVDAA 103

Query: 554 TATGDTALTYACENGHTDVADVLLQAGADLDKQ 586
           T  G+TAL  A   G  +V  VL+  GA+++ Q
Sbjct: 104 TKKGNTALHIASLAGQAEVVKVLVTNGANVNAQ 136


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  182 bits (461), Expect = 1e-45
 Identities = 136/400 (34%), Positives = 201/400 (50%), Gaps = 17/400 (4%)

Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
           G+V  VR LLD G  +   T++  + L  A   G+  ++++LL   A ++ +   G ++P
Sbjct: 283 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 341

Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
           +  A+ G +LD V+LLL +DA+++  +    T L  A   G   + KVLL++GA      
Sbjct: 342 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 401

Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
            NG TPL  A    HV V  +LL  GA I+  +    ES LT   +A + GHL +V+ LL
Sbjct: 402 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 457

Query: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
           + GA       ++ T L  A   GH EVA+ LL + A+VN  A   ++PL  AA  GH  
Sbjct: 458 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 517

Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
           +  LL+E  AN       G+TPL  AAREGH E V  LL + A+    T++   T L +A
Sbjct: 518 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 576

Query: 502 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 558
              G   VA+ L++  A          TPL  A    +L++VK LL  G + H+    G 
Sbjct: 577 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 636

Query: 559 TALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDP 598
           T L  A +    +VA  LLQ G   + +      ++G+ P
Sbjct: 637 TPLHIAAKQNQVEVARSLLQYGGSANAES-----VQGVTP 671



 Score =  178 bits (451), Expect = 1e-44
 Identities = 135/379 (35%), Positives = 196/379 (51%), Gaps = 14/379 (3%)

Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
           G +  V+ LL  G S N    + E+ L +A  AG+ E+A+ LL   A V  +  K D TP
Sbjct: 448 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA-KDDQTP 506

Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
           L  A+  G+ ++VKLLL ++A+ N  +  G+T L  A   G V+ V  LL + A+     
Sbjct: 507 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 566

Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
           + G TPL  AA  G V VA +LL+  A    H N   ++ LT   +A +  +LD+V+ LL
Sbjct: 567 KKGFTPLHVAAKYGKVRVAELLLERDA----HPNAAGKNGLTPLHVAVHHNNLDIVKLLL 622

Query: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
             G          +T L  A     VEVAR LL  G   N  +    +PL LAA  GH E
Sbjct: 623 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 682

Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
           + ALL+ + AN    N  G TPL   A+EGH  +  +L+  G  ++A T     T L +A
Sbjct: 683 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVA 741

Query: 502 CCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATG 557
              G  ++  FL++  AD+    +LG S PL +A+Q+GH ++V  LL +GA+ +  ++ G
Sbjct: 742 SHYGNIKLVKFLLQHQADVNAKTKLGYS-PLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 800

Query: 558 DTALTYACENGHTDVADVL 576
            T L  A   G+  V DVL
Sbjct: 801 TTPLAIAKRLGYISVTDVL 819



 Score =  177 bits (450), Expect = 2e-44
 Identities = 140/427 (32%), Positives = 214/427 (50%), Gaps = 38/427 (8%)

Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
           A  +G V  V +LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG
Sbjct: 85  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 144

Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 318
             TPL  A+   +L++VK LL + A+ N  +  G T L  A   G  ++V  L+N G   
Sbjct: 145 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 203

Query: 319 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 351
                                      N +  ++ G TPL  AA   ++ VA++LL+ GA
Sbjct: 204 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 263

Query: 352 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 410
            +N T  N    + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++
Sbjct: 264 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 321

Query: 411 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 470
            +LLD GA +     +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  
Sbjct: 322 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 381

Query: 471 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 527
           GH  +  +LL +GA  N++      T L +AC      V + L+K GA I+       TP
Sbjct: 382 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 440

Query: 528 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQ 586
           L  AS  GHL +VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A ++ K 
Sbjct: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500

Query: 587 EDMKTIL 593
           +D +T L
Sbjct: 501 KDDQTPL 507



 Score =  173 bits (438), Expect = 5e-43
 Identities = 133/384 (34%), Positives = 193/384 (50%), Gaps = 6/384 (1%)

Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
           AC    V  +  LL  G S++  TE G + L +A   G+  + + LL   A+      K 
Sbjct: 411 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 470

Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
           + TPL  A+  G+ ++ K LL + A VN+++    T L  A   G  ++VK+LL   AN 
Sbjct: 471 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 529

Query: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 380
                 GHTPL  AA  GHVE    LL+  A     + +   + L +A   G + +   L
Sbjct: 530 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 588

Query: 381 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 440
           LE  A          T L  A    ++++ +LLL  G   + PA +  +PL +AA    V
Sbjct: 589 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 648

Query: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
           E+A  L++ G +    + +G TPL  AA+EGH EMVALLL++ AN N   +    T L L
Sbjct: 649 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 707

Query: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557
               G   VAD LIK G  ++       TPL  AS  G+++LVK+LL   A+V+A T  G
Sbjct: 708 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 767

Query: 558 DTALTYACENGHTDVADVLLQAGA 581
            + L  A + GHTD+  +LL+ GA
Sbjct: 768 YSPLHQAAQQGHTDIVTLLLKNGA 791



 Score =  170 bits (431), Expect = 3e-42
 Identities = 132/434 (30%), Positives = 204/434 (47%), Gaps = 43/434 (9%)

Query: 192 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 245
           Q++T++  E      A  +G V     LLD G  +   T+ G S + +A    + +  ++
Sbjct: 297 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 356

Query: 246 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 305
           LL   A ++D      +TPL  A+  G+  + K+LL   A  NS++  G T L  AC   
Sbjct: 357 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 415

Query: 306 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 365
            V ++++LL  GA+I+   E+G TPL  A+  GH+ + + LL  GA  N  SN   E+ L
Sbjct: 416 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 474

Query: 366 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 425
            +A   GH ++ ++LL+  A    K  +  T L  A   GH  + +LLL++ A  N+   
Sbjct: 475 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 534

Query: 426 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 485
           +  +PL +AA  GHVE    L+E+ A+   +  +G+TPL  AA+ G   +  LLL + A+
Sbjct: 535 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 594

Query: 486 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 513
            NA  +                                    T L +A      EVA  L
Sbjct: 595 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 654

Query: 514 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 570
           ++ G           TPL  A+QEGH E+V  LL+  AN +    +G T L    + GH 
Sbjct: 655 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 714

Query: 571 DVADVLLQAGADLD 584
            VADVL++ G  +D
Sbjct: 715 PVADVLIKHGVMVD 728



 Score =  162 bits (409), Expect = 1e-39
 Identities = 123/383 (32%), Positives = 183/383 (47%), Gaps = 6/383 (1%)

Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
           G     + LLD+G   N     G + L +AC   +  + ++LL   A++ D   +  +TP
Sbjct: 382 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-DAVTESGLTP 440

Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
           L  AS  G+L IVK LL   A  N  +    T L  A   G  ++ K LL   A +    
Sbjct: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500

Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 384
           ++  TPL  AA  GH  + ++LL++ A  N  +     + L +A  +GH++ V  LLE  
Sbjct: 501 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKE 559

Query: 385 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 444
           A Q   T +  T L  A   G V VA LLL+  A  N    +  +PL +A    ++++  
Sbjct: 560 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 619

Query: 445 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 504
           LL+ RG +       GYTPL  AA++   E+   LL  G + NA++ +   T L LA   
Sbjct: 620 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQE 678

Query: 505 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561
           G +E+   L+   A+  LG     TPL   +QEGH+ +   L+  G  V ATT  G T L
Sbjct: 679 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 738

Query: 562 TYACENGHTDVADVLLQAGADLD 584
             A   G+  +   LLQ  AD++
Sbjct: 739 HVASHYGNIKLVKFLLQHQADVN 761



 Score =  150 bits (380), Expect = 3e-36
 Identities = 112/359 (31%), Positives = 175/359 (48%), Gaps = 34/359 (9%)

Query: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
           N+  +  L  AS  G++ +V  LL  +  + + +  GNTAL  A   G  ++V+ L+N G
Sbjct: 75  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 134

Query: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377
           AN+   ++ G TPL  AA   H+EV + LL++GA  N  + E   + L +A  +GH ++V
Sbjct: 135 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 193

Query: 378 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 408
             L+  G   + +   +H                             T L  A    ++ 
Sbjct: 194 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 253

Query: 409 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 468
           VA+LLL+ GA VN    +  +PL +A+  G+V +  LL++RGA +E    +  TPL  AA
Sbjct: 254 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 313

Query: 469 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 525
           R GH  +  +LL  GA I A+T+    + + +A  G   +    L++  A   DI L   
Sbjct: 314 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 372

Query: 526 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
           TPL  A+  GH  + K LL  GA  ++    G T L  AC+  H  V ++LL+ GA +D
Sbjct: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 431



 Score =  140 bits (354), Expect = 3e-33
 Identities = 110/336 (32%), Positives = 169/336 (50%), Gaps = 14/336 (4%)

Query: 255 DRGNKGDI-TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
           DR  K D  T  + A+  G LD     L +  D+N+ +  G   L  A   G V +V  L
Sbjct: 38  DRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 97

Query: 314 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 373
           L++   +E   + G+T L  AA AG  EV R L+++GA +N  S +   + L +A  + H
Sbjct: 98  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENH 156

Query: 374 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPL 431
           L++V+FLLE GA+Q   T++  T L  A   GH  V   L++ G   +V +PA      L
Sbjct: 157 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------L 210

Query: 432 TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTE 491
            +AA       AA+L++   N + ++  G+TPL  AA   +  +  LLL +GA++N  T 
Sbjct: 211 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TP 269

Query: 492 ETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGA 548
           +   T L +A   G   +   L+  GA IE       TPL  A++ GH+ + + LL  GA
Sbjct: 270 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 329

Query: 549 NVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
            + A T  G + +  A +  H D   +LLQ  A++D
Sbjct: 330 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 365


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  182 bits (461), Expect = 1e-45
 Identities = 136/400 (34%), Positives = 201/400 (50%), Gaps = 17/400 (4%)

Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
           G+V  VR LLD G  +   T++  + L  A   G+  ++++LL   A ++ +   G ++P
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308

Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
           +  A+ G +LD V+LLL +DA+++  +    T L  A   G   + KVLL++GA      
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
            NG TPL  A    HV V  +LL  GA I+  +    ES LT   +A + GHL +V+ LL
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424

Query: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
           + GA       ++ T L  A   GH EVA+ LL + A+VN  A   ++PL  AA  GH  
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
           +  LL+E  AN       G+TPL  AAREGH E V  LL + A+    T++   T L +A
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543

Query: 502 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 558
              G   VA+ L++  A          TPL  A    +L++VK LL  G + H+    G 
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603

Query: 559 TALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDP 598
           T L  A +    +VA  LLQ G   + +      ++G+ P
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAES-----VQGVTP 638



 Score =  178 bits (451), Expect = 1e-44
 Identities = 135/379 (35%), Positives = 196/379 (51%), Gaps = 14/379 (3%)

Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
           G +  V+ LL  G S N    + E+ L +A  AG+ E+A+ LL   A V  +  K D TP
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA-KDDQTP 473

Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
           L  A+  G+ ++VKLLL ++A+ N  +  G+T L  A   G V+ V  LL + A+     
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533

Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
           + G TPL  AA  G V VA +LL+  A    H N   ++ LT   +A +  +LD+V+ LL
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDA----HPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589

Query: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
             G          +T L  A     VEVAR LL  G   N  +    +PL LAA  GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649

Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
           + ALL+ + AN    N  G TPL   A+EGH  +  +L+  G  ++A T     T L +A
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVA 708

Query: 502 CCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATG 557
              G  ++  FL++  AD+    +LG S PL +A+Q+GH ++V  LL +GA+ +  ++ G
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYS-PLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767

Query: 558 DTALTYACENGHTDVADVL 576
            T L  A   G+  V DVL
Sbjct: 768 TTPLAIAKRLGYISVTDVL 786



 Score =  177 bits (450), Expect = 2e-44
 Identities = 140/427 (32%), Positives = 214/427 (50%), Gaps = 38/427 (8%)

Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
           A  +G V  V +LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111

Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 318
             TPL  A+   +L++VK LL + A+ N  +  G T L  A   G  ++V  L+N G   
Sbjct: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170

Query: 319 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 351
                                      N +  ++ G TPL  AA   ++ VA++LL+ GA
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230

Query: 352 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 410
            +N T  N    + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++
Sbjct: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288

Query: 411 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 470
            +LLD GA +     +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348

Query: 471 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 527
           GH  +  +LL +GA  N++      T L +AC      V + L+K GA I+       TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407

Query: 528 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQ 586
           L  AS  GHL +VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A ++ K 
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 587 EDMKTIL 593
           +D +T L
Sbjct: 468 KDDQTPL 474



 Score =  173 bits (438), Expect = 5e-43
 Identities = 133/384 (34%), Positives = 193/384 (50%), Gaps = 6/384 (1%)

Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
           AC    V  +  LL  G S++  TE G + L +A   G+  + + LL   A+      K 
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437

Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
           + TPL  A+  G+ ++ K LL + A VN+++    T L  A   G  ++VK+LL   AN 
Sbjct: 438 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496

Query: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 380
                 GHTPL  AA  GHVE    LL+  A     + +   + L +A   G + +   L
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 555

Query: 381 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 440
           LE  A          T L  A    ++++ +LLL  G   + PA +  +PL +AA    V
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
           E+A  L++ G +    + +G TPL  AA+EGH EMVALLL++ AN N   +    T L L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 674

Query: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557
               G   VAD LIK G  ++       TPL  AS  G+++LVK+LL   A+V+A T  G
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734

Query: 558 DTALTYACENGHTDVADVLLQAGA 581
            + L  A + GHTD+  +LL+ GA
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGA 758



 Score =  170 bits (431), Expect = 3e-42
 Identities = 132/434 (30%), Positives = 204/434 (47%), Gaps = 43/434 (9%)

Query: 192 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 245
           Q++T++  E      A  +G V     LLD G  +   T+ G S + +A    + +  ++
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 246 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 305
           LL   A ++D      +TPL  A+  G+  + K+LL   A  NS++  G T L  AC   
Sbjct: 324 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382

Query: 306 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 365
            V ++++LL  GA+I+   E+G TPL  A+  GH+ + + LL  GA  N  SN   E+ L
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 441

Query: 366 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 425
            +A   GH ++ ++LL+  A    K  +  T L  A   GH  + +LLL++ A  N+   
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501

Query: 426 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 485
           +  +PL +AA  GHVE    L+E+ A+   +  +G+TPL  AA+ G   +  LLL + A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561

Query: 486 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 513
            NA  +                                    T L +A      EVA  L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621

Query: 514 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 570
           ++ G           TPL  A+QEGH E+V  LL+  AN +    +G T L    + GH 
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681

Query: 571 DVADVLLQAGADLD 584
            VADVL++ G  +D
Sbjct: 682 PVADVLIKHGVMVD 695



 Score =  162 bits (409), Expect = 1e-39
 Identities = 123/383 (32%), Positives = 183/383 (47%), Gaps = 6/383 (1%)

Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
           G     + LLD+G   N     G + L +AC   +  + ++LL   A++ D   +  +TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-DAVTESGLTP 407

Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
           L  AS  G+L IVK LL   A  N  +    T L  A   G  ++ K LL   A +    
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 384
           ++  TPL  AA  GH  + ++LL++ A  N  +     + L +A  +GH++ V  LLE  
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKE 526

Query: 385 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 444
           A Q   T +  T L  A   G V VA LLL+  A  N    +  +PL +A    ++++  
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586

Query: 445 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 504
           LL+ RG +       GYTPL  AA++   E+   LL  G + NA++ +   T L LA   
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQE 645

Query: 505 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561
           G +E+   L+   A+  LG     TPL   +QEGH+ +   L+  G  V ATT  G T L
Sbjct: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 705

Query: 562 TYACENGHTDVADVLLQAGADLD 584
             A   G+  +   LLQ  AD++
Sbjct: 706 HVASHYGNIKLVKFLLQHQADVN 728



 Score =  150 bits (380), Expect = 3e-36
 Identities = 112/359 (31%), Positives = 175/359 (48%), Gaps = 34/359 (9%)

Query: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
           N+  +  L  AS  G++ +V  LL  +  + + +  GNTAL  A   G  ++V+ L+N G
Sbjct: 42  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101

Query: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377
           AN+   ++ G TPL  AA   H+EV + LL++GA  N  + E   + L +A  +GH ++V
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160

Query: 378 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 408
             L+  G   + +   +H                             T L  A    ++ 
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220

Query: 409 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 468
           VA+LLL+ GA VN    +  +PL +A+  G+V +  LL++RGA +E    +  TPL  AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280

Query: 469 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 525
           R GH  +  +LL  GA I A+T+    + + +A  G   +    L++  A   DI L   
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339

Query: 526 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
           TPL  A+  GH  + K LL  GA  ++    G T L  AC+  H  V ++LL+ GA +D
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398



 Score =  138 bits (347), Expect = 2e-32
 Identities = 106/327 (32%), Positives = 165/327 (50%), Gaps = 13/327 (3%)

Query: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
           T  + A+  G LD     L +  D+N+ +  G   L  A   G V +V  LL++   +E 
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382
             + G+T L  AA AG  EV R L+++GA +N  S +   + L +A  + HL++V+FLLE
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132

Query: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 440
            GA+Q   T++  T L  A   GH  V   L++ G   +V +PA      L +AA     
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186

Query: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
             AA+L++   N + ++  G+TPL  AA   +  +  LLL +GA++N  T +   T L +
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245

Query: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557
           A   G   +   L+  GA IE       TPL  A++ GH+ + + LL  GA + A T  G
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 558 DTALTYACENGHTDVADVLLQAGADLD 584
            + +  A +  H D   +LLQ  A++D
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEID 332


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  182 bits (461), Expect = 1e-45
 Identities = 136/400 (34%), Positives = 201/400 (50%), Gaps = 17/400 (4%)

Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
           G+V  VR LLD G  +   T++  + L  A   G+  ++++LL   A ++ +   G ++P
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308

Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
           +  A+ G +LD V+LLL +DA+++  +    T L  A   G   + KVLL++GA      
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
            NG TPL  A    HV V  +LL  GA I+  +    ES LT   +A + GHL +V+ LL
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424

Query: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
           + GA       ++ T L  A   GH EVA+ LL + A+VN  A   ++PL  AA  GH  
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
           +  LL+E  AN       G+TPL  AAREGH E V  LL + A+    T++   T L +A
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543

Query: 502 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 558
              G   VA+ L++  A          TPL  A    +L++VK LL  G + H+    G 
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603

Query: 559 TALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDP 598
           T L  A +    +VA  LLQ G   + +      ++G+ P
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAES-----VQGVTP 638



 Score =  178 bits (451), Expect = 1e-44
 Identities = 135/379 (35%), Positives = 196/379 (51%), Gaps = 14/379 (3%)

Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
           G +  V+ LL  G S N    + E+ L +A  AG+ E+A+ LL   A V  +  K D TP
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA-KDDQTP 473

Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
           L  A+  G+ ++VKLLL ++A+ N  +  G+T L  A   G V+ V  LL + A+     
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533

Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
           + G TPL  AA  G V VA +LL+  A    H N   ++ LT   +A +  +LD+V+ LL
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDA----HPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589

Query: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
             G          +T L  A     VEVAR LL  G   N  +    +PL LAA  GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649

Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
           + ALL+ + AN    N  G TPL   A+EGH  +  +L+  G  ++A T     T L +A
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVA 708

Query: 502 CCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATG 557
              G  ++  FL++  AD+    +LG S PL +A+Q+GH ++V  LL +GA+ +  ++ G
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYS-PLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767

Query: 558 DTALTYACENGHTDVADVL 576
            T L  A   G+  V DVL
Sbjct: 768 TTPLAIAKRLGYISVTDVL 786



 Score =  177 bits (450), Expect = 2e-44
 Identities = 140/427 (32%), Positives = 214/427 (50%), Gaps = 38/427 (8%)

Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
           A  +G V  V +LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111

Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 318
             TPL  A+   +L++VK LL + A+ N  +  G T L  A   G  ++V  L+N G   
Sbjct: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170

Query: 319 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 351
                                      N +  ++ G TPL  AA   ++ VA++LL+ GA
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230

Query: 352 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 410
            +N T  N    + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++
Sbjct: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288

Query: 411 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 470
            +LLD GA +     +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348

Query: 471 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 527
           GH  +  +LL +GA  N++      T L +AC      V + L+K GA I+       TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407

Query: 528 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQ 586
           L  AS  GHL +VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A ++ K 
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 587 EDMKTIL 593
           +D +T L
Sbjct: 468 KDDQTPL 474



 Score =  173 bits (438), Expect = 5e-43
 Identities = 133/384 (34%), Positives = 193/384 (50%), Gaps = 6/384 (1%)

Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
           AC    V  +  LL  G S++  TE G + L +A   G+  + + LL   A+      K 
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437

Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
           + TPL  A+  G+ ++ K LL + A VN+++    T L  A   G  ++VK+LL   AN 
Sbjct: 438 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496

Query: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 380
                 GHTPL  AA  GHVE    LL+  A     + +   + L +A   G + +   L
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 555

Query: 381 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 440
           LE  A          T L  A    ++++ +LLL  G   + PA +  +PL +AA    V
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
           E+A  L++ G +    + +G TPL  AA+EGH EMVALLL++ AN N   +    T L L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 674

Query: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557
               G   VAD LIK G  ++       TPL  AS  G+++LVK+LL   A+V+A T  G
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734

Query: 558 DTALTYACENGHTDVADVLLQAGA 581
            + L  A + GHTD+  +LL+ GA
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGA 758



 Score =  170 bits (431), Expect = 3e-42
 Identities = 132/434 (30%), Positives = 204/434 (47%), Gaps = 43/434 (9%)

Query: 192 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 245
           Q++T++  E      A  +G V     LLD G  +   T+ G S + +A    + +  ++
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 246 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 305
           LL   A ++D      +TPL  A+  G+  + K+LL   A  NS++  G T L  AC   
Sbjct: 324 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382

Query: 306 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 365
            V ++++LL  GA+I+   E+G TPL  A+  GH+ + + LL  GA  N  SN   E+ L
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 441

Query: 366 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 425
            +A   GH ++ ++LL+  A    K  +  T L  A   GH  + +LLL++ A  N+   
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501

Query: 426 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 485
           +  +PL +AA  GHVE    L+E+ A+   +  +G+TPL  AA+ G   +  LLL + A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561

Query: 486 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 513
            NA  +                                    T L +A      EVA  L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621

Query: 514 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 570
           ++ G           TPL  A+QEGH E+V  LL+  AN +    +G T L    + GH 
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681

Query: 571 DVADVLLQAGADLD 584
            VADVL++ G  +D
Sbjct: 682 PVADVLIKHGVMVD 695



 Score =  162 bits (409), Expect = 1e-39
 Identities = 123/383 (32%), Positives = 183/383 (47%), Gaps = 6/383 (1%)

Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
           G     + LLD+G   N     G + L +AC   +  + ++LL   A++ D   +  +TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-DAVTESGLTP 407

Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
           L  AS  G+L IVK LL   A  N  +    T L  A   G  ++ K LL   A +    
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 384
           ++  TPL  AA  GH  + ++LL++ A  N  +     + L +A  +GH++ V  LLE  
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKE 526

Query: 385 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 444
           A Q   T +  T L  A   G V VA LLL+  A  N    +  +PL +A    ++++  
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586

Query: 445 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 504
           LL+ RG +       GYTPL  AA++   E+   LL  G + NA++ +   T L LA   
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQE 645

Query: 505 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561
           G +E+   L+   A+  LG     TPL   +QEGH+ +   L+  G  V ATT  G T L
Sbjct: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 705

Query: 562 TYACENGHTDVADVLLQAGADLD 584
             A   G+  +   LLQ  AD++
Sbjct: 706 HVASHYGNIKLVKFLLQHQADVN 728



 Score =  150 bits (380), Expect = 3e-36
 Identities = 112/359 (31%), Positives = 175/359 (48%), Gaps = 34/359 (9%)

Query: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
           N+  +  L  AS  G++ +V  LL  +  + + +  GNTAL  A   G  ++V+ L+N G
Sbjct: 42  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101

Query: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377
           AN+   ++ G TPL  AA   H+EV + LL++GA  N  + E   + L +A  +GH ++V
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160

Query: 378 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 408
             L+  G   + +   +H                             T L  A    ++ 
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220

Query: 409 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 468
           VA+LLL+ GA VN    +  +PL +A+  G+V +  LL++RGA +E    +  TPL  AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280

Query: 469 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 525
           R GH  +  +LL  GA I A+T+    + + +A  G   +    L++  A   DI L   
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339

Query: 526 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
           TPL  A+  GH  + K LL  GA  ++    G T L  AC+  H  V ++LL+ GA +D
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398



 Score =  138 bits (347), Expect = 2e-32
 Identities = 106/327 (32%), Positives = 165/327 (50%), Gaps = 13/327 (3%)

Query: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
           T  + A+  G LD     L +  D+N+ +  G   L  A   G V +V  LL++   +E 
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382
             + G+T L  AA AG  EV R L+++GA +N  S +   + L +A  + HL++V+FLLE
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132

Query: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 440
            GA+Q   T++  T L  A   GH  V   L++ G   +V +PA      L +AA     
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186

Query: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
             AA+L++   N + ++  G+TPL  AA   +  +  LLL +GA++N  T +   T L +
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245

Query: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557
           A   G   +   L+  GA IE       TPL  A++ GH+ + + LL  GA + A T  G
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 558 DTALTYACENGHTDVADVLLQAGADLD 584
            + +  A +  H D   +LLQ  A++D
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEID 332


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  182 bits (461), Expect = 1e-45
 Identities = 136/400 (34%), Positives = 201/400 (50%), Gaps = 17/400 (4%)

Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
           G+V  VR LLD G  +   T++  + L  A   G+  ++++LL   A ++ +   G ++P
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308

Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
           +  A+ G +LD V+LLL +DA+++  +    T L  A   G   + KVLL++GA      
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
            NG TPL  A    HV V  +LL  GA I+  +    ES LT   +A + GHL +V+ LL
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424

Query: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
           + GA       ++ T L  A   GH EVA+ LL + A+VN  A   ++PL  AA  GH  
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
           +  LL+E  AN       G+TPL  AAREGH E V  LL + A+    T++   T L +A
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543

Query: 502 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 558
              G   VA+ L++  A          TPL  A    +L++VK LL  G + H+    G 
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603

Query: 559 TALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDP 598
           T L  A +    +VA  LLQ G   + +      ++G+ P
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAES-----VQGVTP 638



 Score =  178 bits (451), Expect = 1e-44
 Identities = 135/379 (35%), Positives = 196/379 (51%), Gaps = 14/379 (3%)

Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
           G +  V+ LL  G S N    + E+ L +A  AG+ E+A+ LL   A V  +  K D TP
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA-KDDQTP 473

Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
           L  A+  G+ ++VKLLL ++A+ N  +  G+T L  A   G V+ V  LL + A+     
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533

Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
           + G TPL  AA  G V VA +LL+  A    H N   ++ LT   +A +  +LD+V+ LL
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDA----HPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589

Query: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
             G          +T L  A     VEVAR LL  G   N  +    +PL LAA  GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649

Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
           + ALL+ + AN    N  G TPL   A+EGH  +  +L+  G  ++A T     T L +A
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVA 708

Query: 502 CCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATG 557
              G  ++  FL++  AD+    +LG S PL +A+Q+GH ++V  LL +GA+ +  ++ G
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYS-PLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767

Query: 558 DTALTYACENGHTDVADVL 576
            T L  A   G+  V DVL
Sbjct: 768 TTPLAIAKRLGYISVTDVL 786



 Score =  177 bits (450), Expect = 2e-44
 Identities = 140/427 (32%), Positives = 214/427 (50%), Gaps = 38/427 (8%)

Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
           A  +G V  V +LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111

Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 318
             TPL  A+   +L++VK LL + A+ N  +  G T L  A   G  ++V  L+N G   
Sbjct: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170

Query: 319 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 351
                                      N +  ++ G TPL  AA   ++ VA++LL+ GA
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230

Query: 352 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 410
            +N T  N    + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++
Sbjct: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288

Query: 411 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 470
            +LLD GA +     +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348

Query: 471 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 527
           GH  +  +LL +GA  N++      T L +AC      V + L+K GA I+       TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407

Query: 528 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQ 586
           L  AS  GHL +VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A ++ K 
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 587 EDMKTIL 593
           +D +T L
Sbjct: 468 KDDQTPL 474



 Score =  173 bits (438), Expect = 5e-43
 Identities = 133/384 (34%), Positives = 193/384 (50%), Gaps = 6/384 (1%)

Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
           AC    V  +  LL  G S++  TE G + L +A   G+  + + LL   A+      K 
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437

Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
           + TPL  A+  G+ ++ K LL + A VN+++    T L  A   G  ++VK+LL   AN 
Sbjct: 438 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496

Query: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 380
                 GHTPL  AA  GHVE    LL+  A     + +   + L +A   G + +   L
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 555

Query: 381 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 440
           LE  A          T L  A    ++++ +LLL  G   + PA +  +PL +AA    V
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
           E+A  L++ G +    + +G TPL  AA+EGH EMVALLL++ AN N   +    T L L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 674

Query: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557
               G   VAD LIK G  ++       TPL  AS  G+++LVK+LL   A+V+A T  G
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734

Query: 558 DTALTYACENGHTDVADVLLQAGA 581
            + L  A + GHTD+  +LL+ GA
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGA 758



 Score =  170 bits (431), Expect = 3e-42
 Identities = 132/434 (30%), Positives = 204/434 (47%), Gaps = 43/434 (9%)

Query: 192 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 245
           Q++T++  E      A  +G V     LLD G  +   T+ G S + +A    + +  ++
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 246 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 305
           LL   A ++D      +TPL  A+  G+  + K+LL   A  NS++  G T L  AC   
Sbjct: 324 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382

Query: 306 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 365
            V ++++LL  GA+I+   E+G TPL  A+  GH+ + + LL  GA  N  SN   E+ L
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 441

Query: 366 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 425
            +A   GH ++ ++LL+  A    K  +  T L  A   GH  + +LLL++ A  N+   
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501

Query: 426 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 485
           +  +PL +AA  GHVE    L+E+ A+   +  +G+TPL  AA+ G   +  LLL + A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561

Query: 486 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 513
            NA  +                                    T L +A      EVA  L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621

Query: 514 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 570
           ++ G           TPL  A+QEGH E+V  LL+  AN +    +G T L    + GH 
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681

Query: 571 DVADVLLQAGADLD 584
            VADVL++ G  +D
Sbjct: 682 PVADVLIKHGVMVD 695



 Score =  162 bits (409), Expect = 1e-39
 Identities = 123/383 (32%), Positives = 183/383 (47%), Gaps = 6/383 (1%)

Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
           G     + LLD+G   N     G + L +AC   +  + ++LL   A++ D   +  +TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-DAVTESGLTP 407

Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
           L  AS  G+L IVK LL   A  N  +    T L  A   G  ++ K LL   A +    
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 384
           ++  TPL  AA  GH  + ++LL++ A  N  +     + L +A  +GH++ V  LLE  
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKE 526

Query: 385 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 444
           A Q   T +  T L  A   G V VA LLL+  A  N    +  +PL +A    ++++  
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586

Query: 445 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 504
           LL+ RG +       GYTPL  AA++   E+   LL  G + NA++ +   T L LA   
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQE 645

Query: 505 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561
           G +E+   L+   A+  LG     TPL   +QEGH+ +   L+  G  V ATT  G T L
Sbjct: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 705

Query: 562 TYACENGHTDVADVLLQAGADLD 584
             A   G+  +   LLQ  AD++
Sbjct: 706 HVASHYGNIKLVKFLLQHQADVN 728



 Score =  150 bits (380), Expect = 3e-36
 Identities = 112/359 (31%), Positives = 175/359 (48%), Gaps = 34/359 (9%)

Query: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
           N+  +  L  AS  G++ +V  LL  +  + + +  GNTAL  A   G  ++V+ L+N G
Sbjct: 42  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101

Query: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377
           AN+   ++ G TPL  AA   H+EV + LL++GA  N  + E   + L +A  +GH ++V
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160

Query: 378 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 408
             L+  G   + +   +H                             T L  A    ++ 
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220

Query: 409 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 468
           VA+LLL+ GA VN    +  +PL +A+  G+V +  LL++RGA +E    +  TPL  AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280

Query: 469 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 525
           R GH  +  +LL  GA I A+T+    + + +A  G   +    L++  A   DI L   
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339

Query: 526 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
           TPL  A+  GH  + K LL  GA  ++    G T L  AC+  H  V ++LL+ GA +D
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398



 Score =  138 bits (347), Expect = 2e-32
 Identities = 106/327 (32%), Positives = 165/327 (50%), Gaps = 13/327 (3%)

Query: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
           T  + A+  G LD     L +  D+N+ +  G   L  A   G V +V  LL++   +E 
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382
             + G+T L  AA AG  EV R L+++GA +N  S +   + L +A  + HL++V+FLLE
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132

Query: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 440
            GA+Q   T++  T L  A   GH  V   L++ G   +V +PA      L +AA     
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186

Query: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
             AA+L++   N + ++  G+TPL  AA   +  +  LLL +GA++N  T +   T L +
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245

Query: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557
           A   G   +   L+  GA IE       TPL  A++ GH+ + + LL  GA + A T  G
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 558 DTALTYACENGHTDVADVLLQAGADLD 584
            + +  A +  H D   +LLQ  A++D
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEID 332


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  182 bits (461), Expect = 1e-45
 Identities = 136/400 (34%), Positives = 201/400 (50%), Gaps = 17/400 (4%)

Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
           G+V  VR LLD G  +   T++  + L  A   G+  ++++LL   A ++ +   G ++P
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308

Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
           +  A+ G +LD V+LLL +DA+++  +    T L  A   G   + KVLL++GA      
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
            NG TPL  A    HV V  +LL  GA I+  +    ES LT   +A + GHL +V+ LL
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424

Query: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
           + GA       ++ T L  A   GH EVA+ LL + A+VN  A   ++PL  AA  GH  
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
           +  LL+E  AN       G+TPL  AAREGH E V  LL + A+    T++   T L +A
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543

Query: 502 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 558
              G   VA+ L++  A          TPL  A    +L++VK LL  G + H+    G 
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603

Query: 559 TALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDP 598
           T L  A +    +VA  LLQ G   + +      ++G+ P
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAES-----VQGVTP 638



 Score =  178 bits (451), Expect = 1e-44
 Identities = 135/379 (35%), Positives = 196/379 (51%), Gaps = 14/379 (3%)

Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
           G +  V+ LL  G S N    + E+ L +A  AG+ E+A+ LL   A V  +  K D TP
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA-KDDQTP 473

Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
           L  A+  G+ ++VKLLL ++A+ N  +  G+T L  A   G V+ V  LL + A+     
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533

Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
           + G TPL  AA  G V VA +LL+  A    H N   ++ LT   +A +  +LD+V+ LL
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDA----HPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589

Query: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
             G          +T L  A     VEVAR LL  G   N  +    +PL LAA  GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649

Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
           + ALL+ + AN    N  G TPL   A+EGH  +  +L+  G  ++A T     T L +A
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVA 708

Query: 502 CCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATG 557
              G  ++  FL++  AD+    +LG S PL +A+Q+GH ++V  LL +GA+ +  ++ G
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYS-PLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767

Query: 558 DTALTYACENGHTDVADVL 576
            T L  A   G+  V DVL
Sbjct: 768 TTPLAIAKRLGYISVTDVL 786



 Score =  177 bits (450), Expect = 2e-44
 Identities = 140/427 (32%), Positives = 214/427 (50%), Gaps = 38/427 (8%)

Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
           A  +G V  V +LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111

Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 318
             TPL  A+   +L++VK LL + A+ N  +  G T L  A   G  ++V  L+N G   
Sbjct: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170

Query: 319 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 351
                                      N +  ++ G TPL  AA   ++ VA++LL+ GA
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230

Query: 352 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 410
            +N T  N    + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++
Sbjct: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288

Query: 411 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 470
            +LLD GA +     +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348

Query: 471 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 527
           GH  +  +LL +GA  N++      T L +AC      V + L+K GA I+       TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407

Query: 528 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQ 586
           L  AS  GHL +VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A ++ K 
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 587 EDMKTIL 593
           +D +T L
Sbjct: 468 KDDQTPL 474



 Score =  173 bits (438), Expect = 5e-43
 Identities = 133/384 (34%), Positives = 193/384 (50%), Gaps = 6/384 (1%)

Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
           AC    V  +  LL  G S++  TE G + L +A   G+  + + LL   A+      K 
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437

Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
           + TPL  A+  G+ ++ K LL + A VN+++    T L  A   G  ++VK+LL   AN 
Sbjct: 438 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496

Query: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 380
                 GHTPL  AA  GHVE    LL+  A     + +   + L +A   G + +   L
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 555

Query: 381 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 440
           LE  A          T L  A    ++++ +LLL  G   + PA +  +PL +AA    V
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
           E+A  L++ G +    + +G TPL  AA+EGH EMVALLL++ AN N   +    T L L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 674

Query: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557
               G   VAD LIK G  ++       TPL  AS  G+++LVK+LL   A+V+A T  G
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734

Query: 558 DTALTYACENGHTDVADVLLQAGA 581
            + L  A + GHTD+  +LL+ GA
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGA 758



 Score =  170 bits (431), Expect = 3e-42
 Identities = 132/434 (30%), Positives = 204/434 (47%), Gaps = 43/434 (9%)

Query: 192 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 245
           Q++T++  E      A  +G V     LLD G  +   T+ G S + +A    + +  ++
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 246 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 305
           LL   A ++D      +TPL  A+  G+  + K+LL   A  NS++  G T L  AC   
Sbjct: 324 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382

Query: 306 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 365
            V ++++LL  GA+I+   E+G TPL  A+  GH+ + + LL  GA  N  SN   E+ L
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 441

Query: 366 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 425
            +A   GH ++ ++LL+  A    K  +  T L  A   GH  + +LLL++ A  N+   
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501

Query: 426 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 485
           +  +PL +AA  GHVE    L+E+ A+   +  +G+TPL  AA+ G   +  LLL + A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561

Query: 486 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 513
            NA  +                                    T L +A      EVA  L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621

Query: 514 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 570
           ++ G           TPL  A+QEGH E+V  LL+  AN +    +G T L    + GH 
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681

Query: 571 DVADVLLQAGADLD 584
            VADVL++ G  +D
Sbjct: 682 PVADVLIKHGVMVD 695



 Score =  162 bits (409), Expect = 1e-39
 Identities = 123/383 (32%), Positives = 183/383 (47%), Gaps = 6/383 (1%)

Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
           G     + LLD+G   N     G + L +AC   +  + ++LL   A++ D   +  +TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-DAVTESGLTP 407

Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
           L  AS  G+L IVK LL   A  N  +    T L  A   G  ++ K LL   A +    
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 384
           ++  TPL  AA  GH  + ++LL++ A  N  +     + L +A  +GH++ V  LLE  
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKE 526

Query: 385 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 444
           A Q   T +  T L  A   G V VA LLL+  A  N    +  +PL +A    ++++  
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586

Query: 445 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 504
           LL+ RG +       GYTPL  AA++   E+   LL  G + NA++ +   T L LA   
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQE 645

Query: 505 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561
           G +E+   L+   A+  LG     TPL   +QEGH+ +   L+  G  V ATT  G T L
Sbjct: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 705

Query: 562 TYACENGHTDVADVLLQAGADLD 584
             A   G+  +   LLQ  AD++
Sbjct: 706 HVASHYGNIKLVKFLLQHQADVN 728



 Score =  150 bits (380), Expect = 3e-36
 Identities = 112/359 (31%), Positives = 175/359 (48%), Gaps = 34/359 (9%)

Query: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
           N+  +  L  AS  G++ +V  LL  +  + + +  GNTAL  A   G  ++V+ L+N G
Sbjct: 42  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101

Query: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377
           AN+   ++ G TPL  AA   H+EV + LL++GA  N  + E   + L +A  +GH ++V
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160

Query: 378 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 408
             L+  G   + +   +H                             T L  A    ++ 
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220

Query: 409 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 468
           VA+LLL+ GA VN    +  +PL +A+  G+V +  LL++RGA +E    +  TPL  AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280

Query: 469 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 525
           R GH  +  +LL  GA I A+T+    + + +A  G   +    L++  A   DI L   
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339

Query: 526 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
           TPL  A+  GH  + K LL  GA  ++    G T L  AC+  H  V ++LL+ GA +D
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398



 Score =  138 bits (347), Expect = 2e-32
 Identities = 106/327 (32%), Positives = 165/327 (50%), Gaps = 13/327 (3%)

Query: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
           T  + A+  G LD     L +  D+N+ +  G   L  A   G V +V  LL++   +E 
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382
             + G+T L  AA AG  EV R L+++GA +N  S +   + L +A  + HL++V+FLLE
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132

Query: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 440
            GA+Q   T++  T L  A   GH  V   L++ G   +V +PA      L +AA     
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186

Query: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
             AA+L++   N + ++  G+TPL  AA   +  +  LLL +GA++N  T +   T L +
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245

Query: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557
           A   G   +   L+  GA IE       TPL  A++ GH+ + + LL  GA + A T  G
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 558 DTALTYACENGHTDVADVLLQAGADLD 584
            + +  A +  H D   +LLQ  A++D
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEID 332


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  177 bits (448), Expect = 3e-44
 Identities = 142/424 (33%), Positives = 212/424 (50%), Gaps = 45/424 (10%)

Query: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
           +L  A   G     + LLD+  + N     G + L +AC     ++ ++L+   A+++  
Sbjct: 347 ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 406

Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
              G +TP+  A+  G+L+IV LLL + A  +  +  G TAL  A   G V++V+ LL  
Sbjct: 407 TESG-LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 465

Query: 317 GANIEDH---------------------------------NENGHTPLMEAASAGHVEVA 343
           GA ++                                     NG+TPL  +A  G V+VA
Sbjct: 466 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 525

Query: 344 RVLLDHGAGINTHSNEFKE--SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEA 401
            VLL+ GA    HS   K+  + L +A   G LD+ + LL+  A  +       T L  A
Sbjct: 526 SVLLEAGA---AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 582

Query: 402 CMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGY 461
               + +VA LLL+ GA  +  A +  +PL +AA    +++A+ L+  GA    V  +G 
Sbjct: 583 AHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV 642

Query: 462 TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD-- 519
           TPL  A++EGH +MV LLL +GANI+  T ++  T+L LA       VAD L K GAD  
Sbjct: 643 TPLHLASQEGHTDMVTLLLDKGANIHMST-KSGLTSLHLAAQEDKVNVADILTKHGADQD 701

Query: 520 --IELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLL 577
              +LG  TPL+ A   G++++V +LL  GANV+A T  G T L  A + GHT + +VLL
Sbjct: 702 AHTKLG-YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 760

Query: 578 QAGA 581
           Q GA
Sbjct: 761 QHGA 764



 Score =  173 bits (438), Expect = 5e-43
 Identities = 135/416 (32%), Positives = 204/416 (49%), Gaps = 24/416 (5%)

Query: 179 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 238
           +T M  ++  NA      S   A   G+++ V + L  G  +N   + G + L LA   G
Sbjct: 1   MTTMLQKSDSNA------SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEG 54

Query: 239 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 298
           +  L Q LL   ++V+    KG+ T L  AS  G  ++VK+L+   A++N+QS  G T L
Sbjct: 55  HVGLVQELLGRGSSVDSATKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 113

Query: 299 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 358
             A     +D+VK LL  GAN     E+G TPL  A   GH +   +LL+     N    
Sbjct: 114 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKG 168

Query: 359 EFKESALTLACYKGHLDMVRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVA 410
           + +  AL +A  K        LL  +  AD + K      T+   T L  A   G+V VA
Sbjct: 169 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 228

Query: 411 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 470
            LLL+ GA V+  A +  +PL +A+  G+  +  LL++RG  ++    +G TPL  AAR 
Sbjct: 229 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 288

Query: 471 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTP 527
           GH+++V LLL +GA + A+T+    + L +A  G   E    L++  A   D+ L   T 
Sbjct: 289 GHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 347

Query: 528 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583
           L  A+  GH  + K LL   AN +A    G T L  AC+     V ++L++ GA +
Sbjct: 348 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI 403



 Score =  169 bits (429), Expect = 5e-42
 Identities = 141/438 (32%), Positives = 210/438 (47%), Gaps = 45/438 (10%)

Query: 188 HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 247
           +   Q    +L  A  +G V  V++LL  G SV+  T++G + L +A  AG  E+ +VL+
Sbjct: 37  NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 96

Query: 248 AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV 307
              AN+  +   G  TPL  A+   ++D+VK LL + A+ ++ +  G T L  A   G  
Sbjct: 97  KEGANINAQSQNG-FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 155

Query: 308 DIVKVLLNEGANIE------------------------DHN-------------ENGHTP 330
             V +LL      +                        DHN             E+G TP
Sbjct: 156 QAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 215

Query: 331 LMEAASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 389
           L  AA  G+V VA +LL+ GA ++ T  N    + L +A  +G+ +MV+ LL+ G   + 
Sbjct: 216 LHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDA 273

Query: 390 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 449
           KT +  T L  A   GH +V  LLL+ GA +     +  SPL +AA G HVE    L++ 
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 333

Query: 450 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 509
            A +++V  +  T L  AA  GH  +  LLL + AN NA+      T L +AC     +V
Sbjct: 334 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 392

Query: 510 ADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 566
            + L+K GA I+       TP+  A+  GHL +V  LL +GA+   T   G+TAL  A  
Sbjct: 393 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 452

Query: 567 NGHTDVADVLLQAGADLD 584
            G  +V   LL+ GA +D
Sbjct: 453 AGQVEVVRCLLRNGALVD 470



 Score =  168 bits (425), Expect = 2e-41
 Identities = 128/388 (32%), Positives = 196/388 (50%), Gaps = 12/388 (3%)

Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
           A   G+ N V+ LLD G  ++  T +G + L  A  +G+ ++ ++LL   A +  R   G
Sbjct: 252 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 311

Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
            ++PL  A+ G +++ VK LL H A V+  +    TAL  A   G   + K+LL++ AN 
Sbjct: 312 -LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 370

Query: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMV 377
                NG TPL  A     ++V  +L+ +GA I        ES LT   +A + GHL++V
Sbjct: 371 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQA----ITESGLTPIHVAAFMGHLNIV 426

Query: 378 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 437
             LL+ GA  +       TAL  A   G VEV R LL +GA V+  A   ++PL +A+  
Sbjct: 427 LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 486

Query: 438 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 497
           G  E+  LL++  A+ +     GYTPL  +AREG  ++ ++LL  GA  +  T++   T 
Sbjct: 487 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK-GFTP 545

Query: 498 LTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATT 554
           L +A   G  +VA  L++  A  +       TPL  A+   + ++   LL  GA+ HAT 
Sbjct: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605

Query: 555 ATGDTALTYACENGHTDVADVLLQAGAD 582
             G T L  A +     +A  LL  GA+
Sbjct: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAE 633



 Score =  141 bits (355), Expect = 2e-33
 Identities = 126/413 (30%), Positives = 186/413 (45%), Gaps = 11/413 (2%)

Query: 189 NAGQVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 242
           N   VD R+  E      A   G    V+ LL      +  T  G + L ++   G  ++
Sbjct: 465 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 524

Query: 243 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 302
           A VLL   A       K   TPL  A+  G LD+ KLLL   A  +S    G T L  A 
Sbjct: 525 ASVLLEAGA-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 583

Query: 303 AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE 362
                 +  +LL +GA+     +NG+TPL  AA    +++A  LL++GA  N  + +   
Sbjct: 584 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ-GV 642

Query: 363 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 422
           + L LA  +GH DMV  LL+ GA+    T    T+L  A  +  V VA +L   GA  + 
Sbjct: 643 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 702

Query: 423 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
                 +PL +A   G+V++   L+++GAN+      GYTPL +AA++GH  ++ +LL  
Sbjct: 703 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 762

Query: 483 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKY 542
           GA  NA T     TAL +A   G+  V D L K   +     +T + E  +    E +  
Sbjct: 763 GAKPNA-TTANGNTALAIAKRLGYISVVDTL-KVVTEEVTTTTTTITEKHKLNVPETMTE 820

Query: 543 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEG 595
           +L         T TGD    Y       ++ D  L +   LD    ++  LEG
Sbjct: 821 VLDVSDEEGDDTMTGDGG-EYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEG 872



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 64/228 (28%), Positives = 95/228 (41%), Gaps = 16/228 (7%)

Query: 183 KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 242
           K  N H + +    SL  A  +  VN    L   G   + HT+ G + L +AC  G  ++
Sbjct: 663 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 722

Query: 243 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 302
              LL   ANV  +  K   TPL  A+  G+  I+ +LL H A  N+ +A GNTAL  A 
Sbjct: 723 VNFLLKQGANVNAK-TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 781

Query: 303 AGGF---VDIVKVLLNEGAN-----IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN 354
             G+   VD +KV+  E         E H  N    + E       E    +   G G  
Sbjct: 782 RLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDG-GEY 840

Query: 355 THSNEFKE---SALTLACYKGHLDMVRFLLEAGAD---QEHKTDEMHT 396
               + KE    +L  + +   ++ +R+ LE G     +   +D  HT
Sbjct: 841 LRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHT 888



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 35/102 (34%), Positives = 56/102 (54%), Gaps = 6/102 (5%)

Query: 489 QTEETQETALTLACCGGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLL 544
           Q  ++  + L  A  G   +V ++L K G DI   C+      L  A++EGH+ LV+ LL
Sbjct: 6   QKSDSNASFLRAARAGNLDKVVEYL-KGGIDINT-CNQNGLNALHLAAKEGHVGLVQELL 63

Query: 545 ASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQ 586
             G++V + T  G+TAL  A   G  +V  VL++ GA+++ Q
Sbjct: 64  GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQ 105


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  172 bits (436), Expect = 8e-43
 Identities = 131/398 (32%), Positives = 197/398 (49%), Gaps = 18/398 (4%)

Query: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
           S   A   G+++ V + L  G  +N   + G + L LA   G+  L Q LL   ++V+  
Sbjct: 34  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93

Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
             KG+ T L  AS  G  ++VK+L+   A++N+QS  G T L  A     +D+VK LL  
Sbjct: 94  TKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152

Query: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376
           GAN     E+G TPL  A   GH +   +LL+     N    + +  AL +A  K     
Sbjct: 153 GANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKS 207

Query: 377 VRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 428
              LL  +  AD + K      T+   T L  A   G+V VA LLL+ GA V+  A +  
Sbjct: 208 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 267

Query: 429 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 488
           +PL +A+  G+  +  LL++RG  ++    +G TPL  AAR GH+++V LLL +GA + A
Sbjct: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327

Query: 489 QTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTPLMEASQEGHLELVKYLLA 545
           +T+    + L +A  G   E    L++  A   D+ L   T L  A+  GH  + K LL 
Sbjct: 328 RTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386

Query: 546 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583
             AN +A    G T L  AC+     V ++L++ GA +
Sbjct: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI 424



 Score =  169 bits (429), Expect = 5e-42
 Identities = 141/438 (32%), Positives = 210/438 (47%), Gaps = 45/438 (10%)

Query: 188 HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 247
           +   Q    +L  A  +G V  V++LL  G SV+  T++G + L +A  AG  E+ +VL+
Sbjct: 58  NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 117

Query: 248 AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV 307
              AN+  +   G  TPL  A+   ++D+VK LL + A+ ++ +  G T L  A   G  
Sbjct: 118 KEGANINAQSQNG-FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176

Query: 308 DIVKVLLNEGANIE------------------------DHN-------------ENGHTP 330
             V +LL      +                        DHN             E+G TP
Sbjct: 177 QAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 236

Query: 331 LMEAASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 389
           L  AA  G+V VA +LL+ GA ++ T  N    + L +A  +G+ +MV+ LL+ G   + 
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDA 294

Query: 390 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 449
           KT +  T L  A   GH +V  LLL+ GA +     +  SPL +AA G HVE    L++ 
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354

Query: 450 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 509
            A +++V  +  T L  AA  GH  +  LLL + AN NA+      T L +AC     +V
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 413

Query: 510 ADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 566
            + L+K GA I+       TP+  A+  GHL +V  LL +GA+   T   G+TAL  A  
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473

Query: 567 NGHTDVADVLLQAGADLD 584
            G  +V   LL+ GA +D
Sbjct: 474 AGQVEVVRCLLRNGALVD 491



 Score =  168 bits (425), Expect = 2e-41
 Identities = 128/388 (32%), Positives = 196/388 (50%), Gaps = 12/388 (3%)

Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
           A   G+ N V+ LLD G  ++  T +G + L  A  +G+ ++ ++LL   A +  R   G
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332

Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
            ++PL  A+ G +++ VK LL H A V+  +    TAL  A   G   + K+LL++ AN 
Sbjct: 333 -LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391

Query: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMV 377
                NG TPL  A     ++V  +L+ +GA I        ES LT   +A + GHL++V
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQA----ITESGLTPIHVAAFMGHLNIV 447

Query: 378 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 437
             LL+ GA  +       TAL  A   G VEV R LL +GA V+  A   ++PL +A+  
Sbjct: 448 LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 507

Query: 438 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 497
           G  E+  LL++  A+ +     GYTPL  +AREG  ++ ++LL  GA  +  T++   T 
Sbjct: 508 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK-GFTP 566

Query: 498 LTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATT 554
           L +A   G  +VA  L++  A  +       TPL  A+   + ++   LL  GA+ HAT 
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626

Query: 555 ATGDTALTYACENGHTDVADVLLQAGAD 582
             G T L  A +     +A  LL  GA+
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAE 654



 Score =  141 bits (355), Expect = 2e-33
 Identities = 126/413 (30%), Positives = 186/413 (45%), Gaps = 11/413 (2%)

Query: 189 NAGQVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 242
           N   VD R+  E      A   G    V+ LL      +  T  G + L ++   G  ++
Sbjct: 486 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 545

Query: 243 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 302
           A VLL   A       K   TPL  A+  G LD+ KLLL   A  +S    G T L  A 
Sbjct: 546 ASVLLEAGA-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 604

Query: 303 AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE 362
                 +  +LL +GA+     +NG+TPL  AA    +++A  LL++GA  N  + +   
Sbjct: 605 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ-GV 663

Query: 363 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 422
           + L LA  +GH DMV  LL+ GA+    T    T+L  A  +  V VA +L   GA  + 
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723

Query: 423 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
                 +PL +A   G+V++   L+++GAN+      GYTPL +AA++GH  ++ +LL  
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783

Query: 483 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKY 542
           GA  NA T     TAL +A   G+  V D L K   +     +T + E  +    E +  
Sbjct: 784 GAKPNA-TTANGNTALAIAKRLGYISVVDTL-KVVTEEVTTTTTTITEKHKLNVPETMTE 841

Query: 543 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEG 595
           +L         T TGD    Y       ++ D  L +   LD    ++  LEG
Sbjct: 842 VLDVSDEEGDDTMTGDGG-EYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEG 893



 Score =  125 bits (314), Expect = 1e-28
 Identities = 91/297 (30%), Positives = 143/297 (48%), Gaps = 40/297 (13%)

Query: 326 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGA 385
           + +   + AA AG+++     L  G  INT  N+   +AL LA  +GH+ +V+ LL  G+
Sbjct: 30  DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 88

Query: 386 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 445
             +  T + +TAL  A + G  EV ++L+  GA +N  + +  +PL +AA   H+++   
Sbjct: 89  SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148

Query: 446 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ---------GANINAQTEETQET 496
           L+E GAN     ++G+TPL  A ++GH + VA+LL             +I A+ ++T+  
Sbjct: 149 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 208

Query: 497 ALTL---------------------------ACCGGFSEVADFLIKAGADIELGCS---T 526
           AL L                           A   G   VA  L+  GA ++       T
Sbjct: 209 ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 268

Query: 527 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583
           PL  AS+ G+  +VK LL  G  + A T  G T L  A  +GH  V ++LL+ GA L
Sbjct: 269 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 58/189 (30%), Positives = 89/189 (47%), Gaps = 31/189 (16%)

Query: 390 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 449
           K  + + + + A   G+++     L  G  +N    +  + L LAA  GHV L   L+ R
Sbjct: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 450 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 509
           G++++    +G T L  A+  G  E+V +L+ +GANINAQ++             GF   
Sbjct: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQ------------NGF--- 131

Query: 510 ADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGH 569
                           TPL  A+QE H+++VKYLL +GAN    T  G T L  A + GH
Sbjct: 132 ----------------TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGH 175

Query: 570 TDVADVLLQ 578
                +LL+
Sbjct: 176 NQAVAILLE 184



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 64/228 (28%), Positives = 95/228 (41%), Gaps = 16/228 (7%)

Query: 183 KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 242
           K  N H + +    SL  A  +  VN    L   G   + HT+ G + L +AC  G  ++
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 743

Query: 243 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 302
              LL   ANV  +  K   TPL  A+  G+  I+ +LL H A  N+ +A GNTAL  A 
Sbjct: 744 VNFLLKQGANVNAK-TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802

Query: 303 AGGF---VDIVKVLLNEGAN-----IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN 354
             G+   VD +KV+  E         E H  N    + E       E    +   G G  
Sbjct: 803 RLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDG-GEY 861

Query: 355 THSNEFKE---SALTLACYKGHLDMVRFLLEAGAD---QEHKTDEMHT 396
               + KE    +L  + +   ++ +R+ LE G     +   +D  HT
Sbjct: 862 LRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHT 909


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  172 bits (436), Expect = 8e-43
 Identities = 131/398 (32%), Positives = 197/398 (49%), Gaps = 18/398 (4%)

Query: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
           S   A   G+++ V + L  G  +N   + G + L LA   G+  L Q LL   ++V+  
Sbjct: 34  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93

Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
             KG+ T L  AS  G  ++VK+L+   A++N+QS  G T L  A     +D+VK LL  
Sbjct: 94  TKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152

Query: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376
           GAN     E+G TPL  A   GH +   +LL+     N    + +  AL +A  K     
Sbjct: 153 GANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKS 207

Query: 377 VRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 428
              LL  +  AD + K      T+   T L  A   G+V VA LLL+ GA V+  A +  
Sbjct: 208 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 267

Query: 429 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 488
           +PL +A+  G+  +  LL++RG  ++    +G TPL  AAR GH+++V LLL +GA + A
Sbjct: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327

Query: 489 QTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTPLMEASQEGHLELVKYLLA 545
           +T+    + L +A  G   E    L++  A   D+ L   T L  A+  GH  + K LL 
Sbjct: 328 RTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386

Query: 546 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583
             AN +A    G T L  AC+     V ++L++ GA +
Sbjct: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI 424



 Score =  169 bits (429), Expect = 5e-42
 Identities = 141/438 (32%), Positives = 210/438 (47%), Gaps = 45/438 (10%)

Query: 188 HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 247
           +   Q    +L  A  +G V  V++LL  G SV+  T++G + L +A  AG  E+ +VL+
Sbjct: 58  NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 117

Query: 248 AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV 307
              AN+  +   G  TPL  A+   ++D+VK LL + A+ ++ +  G T L  A   G  
Sbjct: 118 KEGANINAQSQNG-FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176

Query: 308 DIVKVLLNEGANIE------------------------DHN-------------ENGHTP 330
             V +LL      +                        DHN             E+G TP
Sbjct: 177 QAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 236

Query: 331 LMEAASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 389
           L  AA  G+V VA +LL+ GA ++ T  N    + L +A  +G+ +MV+ LL+ G   + 
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDA 294

Query: 390 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 449
           KT +  T L  A   GH +V  LLL+ GA +     +  SPL +AA G HVE    L++ 
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354

Query: 450 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 509
            A +++V  +  T L  AA  GH  +  LLL + AN NA+      T L +AC     +V
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 413

Query: 510 ADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 566
            + L+K GA I+       TP+  A+  GHL +V  LL +GA+   T   G+TAL  A  
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473

Query: 567 NGHTDVADVLLQAGADLD 584
            G  +V   LL+ GA +D
Sbjct: 474 AGQVEVVRCLLRNGALVD 491



 Score =  168 bits (425), Expect = 2e-41
 Identities = 128/388 (32%), Positives = 196/388 (50%), Gaps = 12/388 (3%)

Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
           A   G+ N V+ LLD G  ++  T +G + L  A  +G+ ++ ++LL   A +  R   G
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332

Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
            ++PL  A+ G +++ VK LL H A V+  +    TAL  A   G   + K+LL++ AN 
Sbjct: 333 -LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391

Query: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMV 377
                NG TPL  A     ++V  +L+ +GA I        ES LT   +A + GHL++V
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQA----ITESGLTPIHVAAFMGHLNIV 447

Query: 378 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 437
             LL+ GA  +       TAL  A   G VEV R LL +GA V+  A   ++PL +A+  
Sbjct: 448 LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 507

Query: 438 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 497
           G  E+  LL++  A+ +     GYTPL  +AREG  ++ ++LL  GA  +  T++   T 
Sbjct: 508 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK-GFTP 566

Query: 498 LTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATT 554
           L +A   G  +VA  L++  A  +       TPL  A+   + ++   LL  GA+ HAT 
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626

Query: 555 ATGDTALTYACENGHTDVADVLLQAGAD 582
             G T L  A +     +A  LL  GA+
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAE 654



 Score =  141 bits (355), Expect = 2e-33
 Identities = 126/413 (30%), Positives = 186/413 (45%), Gaps = 11/413 (2%)

Query: 189 NAGQVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 242
           N   VD R+  E      A   G    V+ LL      +  T  G + L ++   G  ++
Sbjct: 486 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 545

Query: 243 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 302
           A VLL   A       K   TPL  A+  G LD+ KLLL   A  +S    G T L  A 
Sbjct: 546 ASVLLEAGA-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 604

Query: 303 AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE 362
                 +  +LL +GA+     +NG+TPL  AA    +++A  LL++GA  N  + +   
Sbjct: 605 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ-GV 663

Query: 363 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 422
           + L LA  +GH DMV  LL+ GA+    T    T+L  A  +  V VA +L   GA  + 
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723

Query: 423 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
                 +PL +A   G+V++   L+++GAN+      GYTPL +AA++GH  ++ +LL  
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783

Query: 483 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKY 542
           GA  NA T     TAL +A   G+  V D L K   +     +T + E  +    E +  
Sbjct: 784 GAKPNA-TTANGNTALAIAKRLGYISVVDTL-KVVTEEVTTTTTTITEKHKLNVPETMTE 841

Query: 543 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEG 595
           +L         T TGD    Y       ++ D  L +   LD    ++  LEG
Sbjct: 842 VLDVSDEEGDDTMTGDGG-EYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEG 893



 Score =  125 bits (314), Expect = 1e-28
 Identities = 91/297 (30%), Positives = 143/297 (48%), Gaps = 40/297 (13%)

Query: 326 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGA 385
           + +   + AA AG+++     L  G  INT  N+   +AL LA  +GH+ +V+ LL  G+
Sbjct: 30  DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 88

Query: 386 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 445
             +  T + +TAL  A + G  EV ++L+  GA +N  + +  +PL +AA   H+++   
Sbjct: 89  SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148

Query: 446 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ---------GANINAQTEETQET 496
           L+E GAN     ++G+TPL  A ++GH + VA+LL             +I A+ ++T+  
Sbjct: 149 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 208

Query: 497 ALTL---------------------------ACCGGFSEVADFLIKAGADIELGCS---T 526
           AL L                           A   G   VA  L+  GA ++       T
Sbjct: 209 ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 268

Query: 527 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583
           PL  AS+ G+  +VK LL  G  + A T  G T L  A  +GH  V ++LL+ GA L
Sbjct: 269 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 58/189 (30%), Positives = 89/189 (47%), Gaps = 31/189 (16%)

Query: 390 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 449
           K  + + + + A   G+++     L  G  +N    +  + L LAA  GHV L   L+ R
Sbjct: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 450 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 509
           G++++    +G T L  A+  G  E+V +L+ +GANINAQ++             GF   
Sbjct: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQ------------NGF--- 131

Query: 510 ADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGH 569
                           TPL  A+QE H+++VKYLL +GAN    T  G T L  A + GH
Sbjct: 132 ----------------TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGH 175

Query: 570 TDVADVLLQ 578
                +LL+
Sbjct: 176 NQAVAILLE 184



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 64/228 (28%), Positives = 95/228 (41%), Gaps = 16/228 (7%)

Query: 183 KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 242
           K  N H + +    SL  A  +  VN    L   G   + HT+ G + L +AC  G  ++
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 743

Query: 243 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 302
              LL   ANV  +  K   TPL  A+  G+  I+ +LL H A  N+ +A GNTAL  A 
Sbjct: 744 VNFLLKQGANVNAK-TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802

Query: 303 AGGF---VDIVKVLLNEGAN-----IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN 354
             G+   VD +KV+  E         E H  N    + E       E    +   G G  
Sbjct: 803 RLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDG-GEY 861

Query: 355 THSNEFKE---SALTLACYKGHLDMVRFLLEAGAD---QEHKTDEMHT 396
               + KE    +L  + +   ++ +R+ LE G     +   +D  HT
Sbjct: 862 LRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHT 909


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  169 bits (429), Expect = 5e-42
 Identities = 125/399 (31%), Positives = 202/399 (50%), Gaps = 7/399 (1%)

Query: 194 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 253
           D  SL +A  +GD + VR L+ +   VN    E  + L  A   G  E+ ++L+   A V
Sbjct: 8   DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67

Query: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
             + +K  +TPL  A +    + V++LL H ADVN++     T L  A A   V   + L
Sbjct: 68  NAKDSKW-LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126

Query: 314 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 373
           +   +N+   +  G T L  AA +GH E+ ++LL  GA IN    + +  A+  A Y GH
Sbjct: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR-AIHWAAYMGH 185

Query: 374 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 433
           +++V+ L+  GA+   K  + +T L  A   G + V + LLD G  +N P     +PL +
Sbjct: 186 IEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245

Query: 434 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM-VALLLAQGANINAQTEE 492
           A   G   +   LI+ GA + + N++G+TPL  AA   H  + + LL+  GA++N ++++
Sbjct: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305

Query: 493 TQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGAN 549
            +      A  G FS  +  +I++GA I+      +TPL  A++ GH  L+  L+ SGA+
Sbjct: 306 GKTPLHMTALHGRFSR-SQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD 364

Query: 550 VHATTATGDTALTYACENGHTDVADVLLQAGADLDKQED 588
                  G   L  A  +G +D    LL +G D+D  +D
Sbjct: 365 TAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDD 403



 Score =  156 bits (394), Expect = 6e-38
 Identities = 122/395 (30%), Positives = 201/395 (50%), Gaps = 17/395 (4%)

Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM--HANVEDRGN 258
           +CS+    AV+ LL     VN   +  ++ L +A +    + A+ L+ +  + NV DR  
Sbjct: 84  SCSE---EAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAG 140

Query: 259 KGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA 318
           +   T L  A+  G+ ++VKLLL   A++N+       A+ +A   G +++VK+L++ GA
Sbjct: 141 R---TALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA 197

Query: 319 NIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVR 378
            +   ++  +TPL  AAS+G + V + LLD G  +N   N +  + L +ACY G   +V 
Sbjct: 198 EVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN-EPNAYGNTPLHVACYNGQDVVVN 256

Query: 379 FLLEAGADQEHKTDEMHTALMEACMDGHVEVA-RLLLDSGAQVNMPADSFESPLTLAACG 437
            L++ GA    K ++  T L  A    H  +   LL+ +GA VNM +   ++PL + A  
Sbjct: 257 ELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALH 316

Query: 438 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 497
           G    +  +I+ GA ++  +  G TPL  AAR GHE ++  L+  GA+  A+        
Sbjct: 317 GRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD-TAKRGIHGMFP 375

Query: 498 LTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATT 554
           L LA   GFS+    L+ +G DI+       T L  A+  G+LE +  LL +GA+ +   
Sbjct: 376 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD 435

Query: 555 ATGDTALTYACENGHTDVADVLLQAGA---DLDKQ 586
             G + L YA  N +      L+ +GA   DLD++
Sbjct: 436 KFGRSPLHYAAANCNYQCLFALVGSGASVNDLDER 470



 Score =  136 bits (343), Expect = 5e-32
 Identities = 109/352 (30%), Positives = 175/352 (49%), Gaps = 17/352 (4%)

Query: 253 VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 312
           + D  N+  I+PL  A+  G+   +++L+    D++ ++++G T L  A   G V+ V V
Sbjct: 542 LSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDV 601

Query: 313 LLNEGANI--EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK--ESALTLA 368
           L+N+GA+I  +D+     TP+  AA+ GH E  R+L+ +    N    +    ++ L L+
Sbjct: 602 LINQGASILVKDYILK-RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS 660

Query: 369 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 428
              GH D V  LL  GA+ + K     TAL    + GH E    LL  GA+  +      
Sbjct: 661 VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720

Query: 429 SPLTLAACGGHVELAALLIERGANLEE----VNDEGYTPLMEAAREGHEEMVALLLAQGA 484
           +P+ L+A  GH+ +   L++  A+++      ++ GYT L  A   GHE  V LLL Q  
Sbjct: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ-- 778

Query: 485 NINAQTEETQETALTLACCGGFSEVADFLIKA-GADIELGCS----TPLMEASQEGHLEL 539
            +  +TE    + L  A        A+ LI   GA I         TPL  A+   H+E 
Sbjct: 779 EVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVEC 838

Query: 540 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLL-QAGADLDKQEDMK 590
           ++ LL+  A V++  +TG T L  A ENG T+  ++L+  A A+L  Q++ K
Sbjct: 839 LQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSK 890



 Score =  132 bits (331), Expect = 1e-30
 Identities = 117/399 (29%), Positives = 181/399 (45%), Gaps = 27/399 (6%)

Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
           G  +  + ++  G  ++   + G + L +A   G+  L   L+   A+   RG  G + P
Sbjct: 317 GRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHG-MFP 375

Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
           L  A+  G+ D  + LL    D+++    G T L  A AGG ++ + +LLN GA+    +
Sbjct: 376 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD 435

Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM----VRFL 380
           + G +PL  AA+  + +    L+  GA +N    +  E   T   Y    D     + +L
Sbjct: 436 KFGRSPLHYAAANCNYQCLFALVGSGASVN----DLDERGCTPLHYAATSDTDGKCLEYL 491

Query: 381 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD----------SGAQVNMPADSFE-- 428
           L   A+   +  + + A+  +   GH    +L+            SG  +   +D+    
Sbjct: 492 LRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATI 551

Query: 429 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 488
           SPL LAA  GH +   +L++   +L+  N  G TPL  AA +GH E V +L+ QGA+I  
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611

Query: 489 QTEETQETALTLACCGGFSEVADFLI-----KAGADIELG-CSTPLMEASQEGHLELVKY 542
           +    + T +  A   G SE    LI     +   DI+ G   TPLM +   GH + V  
Sbjct: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671

Query: 543 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 581
           LL  GANV A    G TAL      GH +  D LLQ GA
Sbjct: 672 LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGA 710



 Score =  131 bits (330), Expect = 2e-30
 Identities = 109/378 (28%), Positives = 178/378 (47%), Gaps = 8/378 (2%)

Query: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
           +L  A   G    V+ LL  G ++N   ++    +  A   G+ E+ ++L++  A V  +
Sbjct: 143 ALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK 202

Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
             K   TPL AA+S G + +VK LL    D+N  +A GNT L  AC  G   +V  L++ 
Sbjct: 203 DKKS-YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDC 261

Query: 317 GANIEDHNENGHTPLMEAASAGHVEVA-RVLLDHGAGINTHSNEFKESALTLACYKGHLD 375
           GA +   NE G TPL  AA++ H  +   +L+ +GA +N  S + K + L +    G   
Sbjct: 262 GAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGK-TPLHMTALHGRFS 320

Query: 376 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 435
             + ++++GA  + +    +T L  A   GH  +   L+ SGA           PL LAA
Sbjct: 321 RSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAA 380

Query: 436 CGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQE 495
             G  +    L+  G +++  +D G T L  AA  G+ E + LLL  GA+ N + ++   
Sbjct: 381 LSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFN-KKDKFGR 439

Query: 496 TALTLACCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVH 551
           + L  A      +    L+ +GA +    E GC+     A+ +   + ++YLL + AN  
Sbjct: 440 SPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPG 499

Query: 552 ATTATGDTALTYACENGH 569
                G  A+ Y+   GH
Sbjct: 500 IRDKQGYNAVHYSAAYGH 517



 Score =  130 bits (326), Expect = 5e-30
 Identities = 124/421 (29%), Positives = 190/421 (45%), Gaps = 24/421 (5%)

Query: 171 ALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRS--VNEHTEEGE 228
           AL+    +L  +   NS     +D      A   G V  V  L+++G S  V ++  +  
Sbjct: 565 ALEVLVQSLLDLDVRNSSGRTPLDL-----AAFKGHVECVDVLINQGASILVKDYILK-R 618

Query: 229 SLLCLACSAGYYELAQVLL--AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDAD 286
           + +  A + G+ E  ++L+  A   N  D  +    TPLM +   G+ D V  LL   A+
Sbjct: 619 TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGAN 678

Query: 287 VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVL 346
           V+++   G TAL      G  + V  LL  GA     +  G TP+  +A+ GH+ V   L
Sbjct: 679 VDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGAL 738

Query: 347 LDHGAGINTH---SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 403
           L   A ++ +   ++    +AL  ACY GH   V  LLE    Q+ + +   + L  A +
Sbjct: 739 LQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAF-SPLHCAVI 797

Query: 404 DGHVEVARLLLDS-GAQVNMPADS-FESPLTLAACGGHVELAALLIERGANLEEVNDEGY 461
           + +   A +L+D+ GA +    DS   +PL  AA   HVE   LL+   A +  V+  G 
Sbjct: 798 NDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGK 857

Query: 462 TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIE 521
           TPLM AA  G    V +L++  +      + ++ TAL LAC  G    A  +++   D  
Sbjct: 858 TPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRN 917

Query: 522 L------GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 575
           L         TPL  A++ G   +V+ LL  GA+V A    G T       N   DVAD 
Sbjct: 918 LINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPN--KDVADC 975

Query: 576 L 576
           L
Sbjct: 976 L 976



 Score =  129 bits (325), Expect = 6e-30
 Identities = 119/403 (29%), Positives = 179/403 (44%), Gaps = 20/403 (4%)

Query: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257
           L  A S G ++ V+ LLD G  +NE    G + L +AC  G   +   L+   A V  + 
Sbjct: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKN 269

Query: 258 NKGDITPL--MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 315
            KG  TPL   AAS+ G L  ++LL+ + ADVN +S  G T L      G     + ++ 
Sbjct: 270 EKG-FTPLHFAAASTHGAL-CLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQ 327

Query: 316 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 375
            GA I+  ++NG+TPL  AA  GH  +   L+  GA             L LA   G  D
Sbjct: 328 SGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD-TAKRGIHGMFPLHLAALSGFSD 386

Query: 376 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 435
             R LL +G D +   D   T L  A   G++E   LLL++GA  N       SPL  AA
Sbjct: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446

Query: 436 CGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHE-EMVALLLAQGANINAQTEETQ 494
              + +    L+  GA++ ++++ G TPL  AA    + + +  LL   AN   + ++  
Sbjct: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGY 506

Query: 495 ETALTLACCG--------GFSEVADFLIKAGADIELGCS------TPLMEASQEGHLELV 540
                 A  G              D L++      L  S      +PL  A+  GH + +
Sbjct: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQAL 566

Query: 541 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583
           + L+ S  ++    ++G T L  A   GH +  DVL+  GA +
Sbjct: 567 EVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI 609


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  167 bits (424), Expect = 2e-41
 Identities = 135/461 (29%), Positives = 225/461 (48%), Gaps = 30/461 (6%)

Query: 134 DLRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQV 193
           D+ T+D E +  L     AA   D E++  L  S +           R+ A+++     +
Sbjct: 8   DVNTLDSEKRTPLHV---AAFLGDAEIIELLILSGA-----------RVNAKDN-----M 48

Query: 194 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM--HA 251
               L  A +     AV+ L+     VN   +  ++ L +A +    + A+V++ +    
Sbjct: 49  WLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSV 108

Query: 252 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 311
           NV DRG +   T L  A+  G++++V LLL   A++N+       AL +A   G +D+V 
Sbjct: 109 NVSDRGGR---TALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVA 165

Query: 312 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 371
           +L+N GA +   ++ G+TPL  AAS G + V + LL+ G  I+   N +  +AL +ACY 
Sbjct: 166 LLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYN 224

Query: 372 GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA-RLLLDSGAQVNMPADSFESP 430
           G   +V  L++ GA+     +   T L  A    H  +   LL+++GA VN+ +   +SP
Sbjct: 225 GQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSP 284

Query: 431 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 490
           L + A  G    +  LI+ G  ++ V+ +G TPL  AAR GHE ++  L   GA+  A+ 
Sbjct: 285 LHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD-TAKC 343

Query: 491 EETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASG 547
                  L LA     S+    L+ +G +I+       T L  A+  G++E +K L +SG
Sbjct: 344 GIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSG 403

Query: 548 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQED 588
           A+ H     G T L YA  N H    + L+  GA++++ +D
Sbjct: 404 ADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDD 444



 Score =  127 bits (319), Expect = 3e-29
 Identities = 123/420 (29%), Positives = 177/420 (42%), Gaps = 37/420 (8%)

Query: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257
           L  A S+G +N V+ LL+ G  ++E    G + L +AC  G   +   L+   ANV    
Sbjct: 185 LHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 244

Query: 258 NKGDITPL--MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 315
           N G  TPL   AAS+ G L  ++LL+ + ADVN QS  G + L      G     + L+ 
Sbjct: 245 NNG-FTPLHFAAASTHGAL-CLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQ 302

Query: 316 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 375
            G  I+  +++G+TPL  AA  GH  +   L   GA             L LA    H D
Sbjct: 303 NGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD-TAKCGIHSMFPLHLAALNAHSD 361

Query: 376 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 435
             R LL +G + +       T L  A   G+VE  +LL  SGA  +       +PL  AA
Sbjct: 362 CCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAA 421

Query: 436 CGGHVELAALLIERGANLEEVNDEGYTPL------------------------MEAAREG 471
              H      L+  GAN+ E +D G T L                        +E ARE 
Sbjct: 422 ANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERAREL 481

Query: 472 HEEMVAL----LLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS-- 525
            E+   L    LL   AN + + +E   +    A  G    +   L +  +  E   S  
Sbjct: 482 KEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGA 541

Query: 526 --TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583
             +PL  A+  GH + ++ LL S  ++      G TAL  A   GHT+  + L+  GA +
Sbjct: 542 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601



 Score =  122 bits (305), Expect = 1e-27
 Identities = 114/397 (28%), Positives = 180/397 (45%), Gaps = 20/397 (5%)

Query: 213 LLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM-HANVEDRGNKGDITPLMAASSG 271
           LL    + +   +EG + +  A + G+ +  ++LL   ++  E+  +    +PL  A+  
Sbjct: 493 LLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYN 552

Query: 272 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI-EDHNENGHTP 330
           G+   +++LL    D++ +   G TAL  A   G  + V+ L+N GA+I    N    TP
Sbjct: 553 GHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTP 612

Query: 331 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESA----LTLACYKGHLDMVRFLLEAGAD 386
           L  +   GH    R+LL+     N  + + K++     L LA   GH+D V  LLE  A+
Sbjct: 613 LHASVINGHTLCLRLLLE--IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670

Query: 387 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 446
            +       TAL    M GH E  ++LL+    +        +PL  AA  GH    + L
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSEL 730

Query: 447 IERGANLEEV---NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACC 503
           ++   + E+    +++GYTPL  A   G+E  + +LL Q      +      T L  A  
Sbjct: 731 LQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ--KCFRKFIGNPFTPLHCAII 788

Query: 504 GGFSEVADFLIKAGADIELGCS-----TPLMEASQEGHLELVKYLLASGANVHATTATGD 558
                 A  L+ A     + C      TPL  A+   H+E ++ LL   A V+A   +G 
Sbjct: 789 NDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGK 848

Query: 559 TALTYACENGHTDVADVLL-QAGADLD-KQEDMKTIL 593
           TAL  A ENG     D+L+  A ADL  K +D+ T L
Sbjct: 849 TALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPL 885



 Score =  114 bits (285), Expect = 3e-25
 Identities = 91/310 (29%), Positives = 147/310 (47%), Gaps = 7/310 (2%)

Query: 280 LLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAG 338
           +L+H   DVN+  +   T L  A   G  +I+++L+  GA +   +    TPL  A ++ 
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 339 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 398
             E  +VL+ H A +N     + ++ L +A     +     ++   +          TAL
Sbjct: 61  SEEAVQVLIKHSADVNARDKNW-QTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119

Query: 399 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 458
             A ++GHVE+  LLL  GA +N         L  AA  GH+++ ALLI  GA +   + 
Sbjct: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179

Query: 459 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 518
           +GYTPL  AA  G   +V  LL  G  I+ +      TAL +AC  G   V + LI  GA
Sbjct: 180 KGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQDAVVNELIDYGA 238

Query: 519 DIELGCS---TPLMEASQEGHLEL-VKYLLASGANVHATTATGDTALTYACENGHTDVAD 574
           ++    +   TPL  A+   H  L ++ L+ +GA+V+  +  G + L     +G    + 
Sbjct: 239 NVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQ 298

Query: 575 VLLQAGADLD 584
            L+Q G ++D
Sbjct: 299 TLIQNGGEID 308



 Score =  107 bits (268), Expect = 2e-23
 Identities = 78/244 (31%), Positives = 125/244 (51%), Gaps = 5/244 (2%)

Query: 345 VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 404
           +L+     +NT  +E K + L +A + G  +++  L+ +GA    K +   T L  A   
Sbjct: 1   MLIHKTEDVNTLDSE-KRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVAS 59

Query: 405 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPL 464
              E  ++L+   A VN    ++++PL +AA    V+ A ++I   +++   +  G T L
Sbjct: 60  RSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119

Query: 465 MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI---E 521
             AA  GH EMV LLLA+GANINA  ++    AL  A   G  +V   LI  GA++   +
Sbjct: 120 HHAALNGHVEMVNLLLAKGANINA-FDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKD 178

Query: 522 LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 581
               TPL  A+  G + +VK+LL  G  +      G+TAL  AC NG   V + L+  GA
Sbjct: 179 KKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGA 238

Query: 582 DLDK 585
           ++++
Sbjct: 239 NVNQ 242



 Score =  104 bits (259), Expect = 3e-22
 Identities = 105/409 (25%), Positives = 175/409 (42%), Gaps = 47/409 (11%)

Query: 179 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 238
           L +    + H   +     L  A ++   + +  L+  G +VNE  + G + L  A ++ 
Sbjct: 398 LLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASD 457

Query: 239 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 298
                 +L   H N E+     ++    A         ++ LL +DA+ + +   G  ++
Sbjct: 458 MDRNKTILGNAHDNSEELERARELKEKEATL------CLEFLLQNDANPSIRDKEGYNSI 511

Query: 299 TYACAGGFVDIVKVLLNEGANIEDHNENGHT--PLMEAASAGHVEVARVLLDHGAGINTH 356
            YA A G    +++LL    +  + +++G T  PL  AA  GH +   VLL     ++  
Sbjct: 512 HYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIR 571

Query: 357 SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD-EMHTALMEACMDGHVEVARLLL- 414
            +E   +AL LA +KGH + V  L+  GA    K +    T L  + ++GH    RLLL 
Sbjct: 572 -DEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLE 630

Query: 415 --DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGH 472
             D+   V++     ++PL LA   GH++  +LL+E+ AN++ V+  G T L      GH
Sbjct: 631 IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGH 690

Query: 473 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEAS 532
           EE V +LL Q  +I  +    +                               TPL  A+
Sbjct: 691 EECVQMLLEQEVSILCKDSRGR-------------------------------TPLHYAA 719

Query: 533 QEGHLELVKYLL---ASGANVHATTATGDTALTYACENGHTDVADVLLQ 578
             GH   +  LL    S  +       G T L +AC NG+ +  +VLL+
Sbjct: 720 ARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 107/388 (27%), Positives = 169/388 (43%), Gaps = 33/388 (8%)

Query: 152 AAAFADPEVLRRLTSSVSCALDEAAAALTR----MKAENSHN-AGQVDTRSLAE------ 200
           AAA+   + L  L    +   +E+ +  T+    + A N H+ A +V  +SL +      
Sbjct: 514 AAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDE 573

Query: 201 --------ACSDGDVNAVRKLLDEGRSVN-EHTEEGESLLCLACSAGYYELAQVLLAMHA 251
                   A   G    V  L++ G S+  +      + L  +   G+    ++LL +  
Sbjct: 574 KGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIAD 633

Query: 252 N---VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVD 308
           N   V+ +  KG  TPLM A + G++D V LLL  +A+V++    G TAL      G  +
Sbjct: 634 NPEAVDVKDAKGQ-TPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEE 692

Query: 309 IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE----SA 364
            V++LL +  +I   +  G TPL  AA+ GH      LL     ++     FK+    + 
Sbjct: 693 CVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQ--MALSEEDCCFKDNQGYTP 750

Query: 365 LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS--GAQVNM 422
           L  ACY G+ + +  LLE    ++       T L  A ++ H   A LLL +   + V+ 
Sbjct: 751 LHWACYNGNENCIEVLLEQKCFRKF-IGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSC 809

Query: 423 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
             D   +PL  AA   HVE   LL+   A +  V++ G T LM AA  G    V +L+  
Sbjct: 810 RDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNS 869

Query: 483 GANINAQTEETQETALTLACCGGFSEVA 510
                   ++   T L LAC  G  + A
Sbjct: 870 AQADLTVKDKDLNTPLHLACSKGHEKCA 897



 Score = 79.7 bits (195), Expect = 7e-15
 Identities = 77/275 (28%), Positives = 121/275 (44%), Gaps = 9/275 (3%)

Query: 212 KLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSG 271
           ++ D   +V+    +G++ L LA + G+ +   +LL   ANV+     G  T L      
Sbjct: 630 EIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILG-CTALHRGIMT 688

Query: 272 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED---HNENGH 328
           G+ + V++LL  +  +  + + G T L YA A G    +  LL    + ED    +  G+
Sbjct: 689 GHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGY 748

Query: 329 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA--GAD 386
           TPL  A   G+     VLL+         N F  + L  A    H +    LL A   + 
Sbjct: 749 TPLHWACYNGNENCIEVLLEQKCFRKFIGNPF--TPLHCAIINDHGNCASLLLGAIDSSI 806

Query: 387 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 446
              + D+  T L  A    HVE  +LLL   A VN   +S ++ L +AA  G      +L
Sbjct: 807 VSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL 866

Query: 447 IERG-ANLEEVNDEGYTPLMEAAREGHEEMVALLL 480
           +    A+L   + +  TPL  A  +GHE+   L+L
Sbjct: 867 VNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 87/316 (27%), Positives = 137/316 (43%), Gaps = 50/316 (15%)

Query: 146 LEALLE--AAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRS------ 197
           +EAL+   A+ F    V +R  + +  ++        R+  E + N   VD +       
Sbjct: 591 VEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 648

Query: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257
           L  A + G ++AV  LL++  +V+     G + L      G+ E  Q+LL    ++  + 
Sbjct: 649 LMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKD 708

Query: 258 NKGDITPLMAASSGGYLDIVKLLL---LHDADVNSQSATGNTALTYACAGGFVDIVKVLL 314
           ++G  TPL  A++ G+   +  LL   L + D   +   G T L +AC  G  + ++VLL
Sbjct: 709 SRGR-TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLL 767

Query: 315 NEG---------------ANIEDH-------------------NENGHTPLMEAASAGHV 340
            +                A I DH                   ++ G TPL  AA A HV
Sbjct: 768 EQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHV 827

Query: 341 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE-AGADQEHKTDEMHTALM 399
           E  ++LL H A +N   N  K +AL +A   G    V  L+  A AD   K  +++T L 
Sbjct: 828 ECLQLLLRHSAPVNAVDNSGK-TALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLH 886

Query: 400 EACMDGHVEVARLLLD 415
            AC  GH + A L+LD
Sbjct: 887 LACSKGHEKCALLILD 902



 Score = 34.3 bits (77), Expect = 0.35
 Identities = 29/94 (30%), Positives = 45/94 (47%), Gaps = 4/94 (4%)

Query: 225 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSG--GYLDIVKLLLL 282
           ++G + L  A  A + E  Q+LL   A V    N G    +MAA +G  G +DI  L+  
Sbjct: 812 DKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDI--LVNS 869

Query: 283 HDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
             AD+  +    NT L  AC+ G      ++L++
Sbjct: 870 AQADLTVKDKDLNTPLHLACSKGHEKCALLILDK 903


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score =  167 bits (422), Expect = 3e-41
 Identities = 120/394 (30%), Positives = 210/394 (53%), Gaps = 12/394 (3%)

Query: 195 TRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL--AMHAN 252
           ++S+     + ++ A++ LL++ + V+E  E G++ L +A   G  E+ + L+    + N
Sbjct: 6   SQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCN 65

Query: 253 VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 312
           +ED  N    T L++AS  G++ IV+ LL    ++  +   G TAL +AC  G  D+V++
Sbjct: 66  LEDLDNW---TALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVEL 122

Query: 313 LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 372
           LL+ GAN          P++ AA  GH ++  +LL +GA +N  S+++  + L  A  KG
Sbjct: 123 LLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNC-SDKYGTTPLVWAARKG 181

Query: 373 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 432
           HL+ V+ LL  GAD + +     TAL+ A   G+ +  + +L     VN+      + L 
Sbjct: 182 HLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALM 241

Query: 433 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492
           +A+  GH E+   L++ G  +   +  G T L+ A R GH E+V  LL + A+I+ + ++
Sbjct: 242 IASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQD 301

Query: 493 TQETALTLACCGGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGA 548
             +TAL  A   G + +   +++   D E+ C+    TPL++A++  ++E+V+ LL  GA
Sbjct: 302 -NKTALYWAVEKGNATMVRDILQCNPDTEI-CTKDGETPLIKATKMRNIEVVELLLDKGA 359

Query: 549 NVHATTATGDTALTYACENGHTDVADVLLQAGAD 582
            V A    GDT L  A       +A++LL+   D
Sbjct: 360 KVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKD 393



 Score =  166 bits (421), Expect = 4e-41
 Identities = 107/291 (36%), Positives = 163/291 (56%), Gaps = 6/291 (2%)

Query: 307 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 366
           +  +K LL +  ++++ NE G TPLM AA  G++E+ + L+ +GA  N    +   +AL 
Sbjct: 18  IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLD-NWTALI 76

Query: 367 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 426
            A  +GH+ +V  LL+ G + EH+     TALM AC  G  +V  LLL  GA  ++    
Sbjct: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136

Query: 427 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 486
              P+  AA  GH ++  LL++ GA +   +  G TPL+ AAR+GH E V  LLA GA++
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196

Query: 487 NAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYL 543
           + Q      TAL +A  GG+++    ++K   ++ L     +T LM AS+EGH E+V+ L
Sbjct: 197 D-QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255

Query: 544 LASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQEDMKTIL 593
           L +G  V+    +GDT L  A   GH ++   LLQ  AD+D + +D KT L
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTAL 306



 Score =  139 bits (349), Expect = 1e-32
 Identities = 97/311 (31%), Positives = 154/311 (49%), Gaps = 5/311 (1%)

Query: 277 VKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAAS 336
           +K LL    DV+ ++  G T L  A   G ++IVK L+  GAN    + +  T L+ A+ 
Sbjct: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80

Query: 337 AGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHT 396
            GHV +   LL  G  +  H +    +AL  ACYKG  D+V  LL  GA+          
Sbjct: 81  EGHVHIVEELLKCGVNLE-HRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVY 139

Query: 397 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEV 456
            ++ A   GH ++  LLL +GA+VN       +PL  AA  GH+E    L+  GA++++ 
Sbjct: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199

Query: 457 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA 516
                T L+ A + G+ + V  +L +  N+N  T++   TAL +A   G +E+   L+ A
Sbjct: 200 GANSMTALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASKEGHTEIVQDLLDA 258

Query: 517 GADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVA 573
           G  + +      T L+ A + GH+E+V+ LL   A++        TAL +A E G+  + 
Sbjct: 259 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 318

Query: 574 DVLLQAGADLD 584
             +LQ   D +
Sbjct: 319 RDILQCNPDTE 329



 Score = 36.2 bits (82), Expect = 0.091
 Identities = 30/96 (31%), Positives = 43/96 (44%), Gaps = 1/96 (1%)

Query: 191 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 250
           GQ +  +L  A   G+   VR +L         T++GE+ L  A      E+ ++LL   
Sbjct: 299 GQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKG 358

Query: 251 ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDAD 286
           A V     KGD TPL  A  G    + +LLL +  D
Sbjct: 359 AKVSAVDKKGD-TPLHIAIRGRSRKLAELLLRNPKD 393


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  159 bits (403), Expect = 5e-39
 Identities = 136/434 (31%), Positives = 213/434 (49%), Gaps = 15/434 (3%)

Query: 126 LSSTAEGADLRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAE 185
           LS    G       PE  +R  +  +  +    + L  ++S  S      + +L+  +  
Sbjct: 336 LSQLDSGVSQAVEGPEELSRSSSESKLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREP 395

Query: 186 NSHNAGQVDT--RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELA 243
           ++ + G  D   + L +A   GD + + K+L + + V+   + G SLL LA  AG  E A
Sbjct: 396 STSDLGTTDVQKKKLVDAIVSGDTSKLMKIL-QPQDVDLALDSGASLLHLAVEAGQEECA 454

Query: 244 QVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACA 303
           + LL  +AN      +G  TPL  A       +V+LLL     VN++     TAL +A  
Sbjct: 455 KWLLLNNANPNLSNRRGS-TPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQ 513

Query: 304 GGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKES 363
            G     ++LL + A++ + +  G TP+  A   G   + R+LL  G  ++      K++
Sbjct: 514 NGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQG---KDA 570

Query: 364 ALTL--ACYKGHLDMVRFLL-EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 420
            L L  A ++GHL +V+ L  + G     +T +  T L  A   GH  VAR+L+D  + V
Sbjct: 571 WLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDV 630

Query: 421 NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 480
           N+ +   ++PL +AA  GH   A LL+ RGA  E +  +GYT L  AAR GH   V LL+
Sbjct: 631 NVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLV 690

Query: 481 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA-DI--ELGCSTPLMEASQEGHL 537
            + A++ A+    Q TAL LA   G SEV + L+ A   D+  E G S  L  A+Q  H 
Sbjct: 691 EEKADVLARGPLNQ-TALHLAAAHGHSEVVEELVSADVIDLFDEQGLSA-LHLAAQGRHA 748

Query: 538 ELVKYLLASGANVH 551
           + V+ LL  GA+++
Sbjct: 749 QTVETLLRHGAHIN 762



 Score =  110 bits (275), Expect = 4e-24
 Identities = 88/263 (33%), Positives = 132/263 (50%), Gaps = 6/263 (2%)

Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
           A  +GD ++ R LL++  SVNE   EG + + +AC  G   + ++LL    +V  +G K 
Sbjct: 511 AAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQG-KD 569

Query: 261 DITPLMAASSGGYLDIVKLLLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 319
              PL  A+  G+L IVKLL       VN+Q+  G T L  A   G   + ++L++  ++
Sbjct: 570 AWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSD 629

Query: 320 IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRF 379
           +   +    TPL  AA  GH   AR+LL  GAG    +++   +AL LA   GHL  V+ 
Sbjct: 630 VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSD-GYTALHLAARNGHLATVKL 688

Query: 380 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 439
           L+E  AD   +     TAL  A   GH EV   L+ S   +++  +   S L LAA G H
Sbjct: 689 LVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV-SADVIDLFDEQGLSALHLAAQGRH 747

Query: 440 VELAALLIERGA--NLEEVNDEG 460
            +    L+  GA  NL+ +  +G
Sbjct: 748 AQTVETLLRHGAHINLQSLKFQG 770



 Score =  106 bits (264), Expect = 7e-23
 Identities = 87/264 (32%), Positives = 127/264 (48%), Gaps = 8/264 (3%)

Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 384
           ++G + L  A  AG  E A+ LL + A  N  SN    + L +A  +    +V  LL   
Sbjct: 436 DSGASLLHLAVEAGQEECAKWLLLNNANPNL-SNRRGSTPLHMAVERRVRGVVELLLARK 494

Query: 385 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 444
                K ++  TAL  A  +G     RLLL+  A VN       +P+ +A   G   +  
Sbjct: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554

Query: 445 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ-GANINAQTEETQETALTLACC 503
           +L+ RG ++     + + PL  AA +GH  +V LL  Q G ++NAQT + + T L LA  
Sbjct: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGR-TPLHLAAQ 613

Query: 504 GGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGANVHATTATGDT 559
            G   VA  LI   +D+ + CS    TPL  A++ GH    + LL  GA   A T+ G T
Sbjct: 614 RGHYRVARILIDLCSDVNV-CSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYT 672

Query: 560 ALTYACENGHTDVADVLLQAGADL 583
           AL  A  NGH     +L++  AD+
Sbjct: 673 ALHLAARNGHLATVKLLVEEKADV 696



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 54/196 (27%), Positives = 79/196 (40%), Gaps = 32/196 (16%)

Query: 391 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 450
           TD     L++A + G       +L     V++  DS  S L LA   G  E A  L+   
Sbjct: 403 TDVQKKKLVDAIVSGDTSKLMKILQP-QDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461

Query: 451 ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVA 510
           AN    N  G TPL  A       +V LLLA+  ++NA+ E+ Q TAL  A         
Sbjct: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDED-QWTALHFA--------- 511

Query: 511 DFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 570
                                +Q G     + LL   A+V+     G T +  AC++G  
Sbjct: 512 ---------------------AQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550

Query: 571 DVADVLLQAGADLDKQ 586
           ++  +LL+ G D+  Q
Sbjct: 551 NIVRILLRRGVDVSLQ 566



 Score = 32.7 bits (73), Expect = 1.0
 Identities = 31/107 (28%), Positives = 46/107 (42%), Gaps = 3/107 (2%)

Query: 490 TEETQETALTLACCGG-FSEVADFLIKAGADIELGCSTPLMEASQE-GHLELVKYLLASG 547
           T + Q+  L  A   G  S++   L     D+ L     L+  + E G  E  K+LL + 
Sbjct: 402 TTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461

Query: 548 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQEDMKTIL 593
           AN + +   G T L  A E     V ++LL     ++ K ED  T L
Sbjct: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTAL 508


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  154 bits (389), Expect = 2e-37
 Identities = 123/353 (34%), Positives = 167/353 (47%), Gaps = 6/353 (1%)

Query: 238 GYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTA 297
           G  E  ++LLA   +V+ +   G  TPL+ A+     D+  LLL H AD N     G   
Sbjct: 373 GSVEQVRLLLAHEVDVDCQTASG-YTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAP 431

Query: 298 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 357
           L +A   G     ++LL+ GA ++     G TPL  AA      VAR+L+   A  N H 
Sbjct: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE 491

Query: 358 NEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 417
            E K + L +A Y GH+ +V+ L   GA+ + +   + T L  A   G V   + LL SG
Sbjct: 492 AEGK-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550

Query: 418 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 477
           A  +    S   PL  AA  G   +  +L+  GA+LE    +G+TPL  AA +GH E++ 
Sbjct: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610

Query: 478 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD---IELGCSTPLMEASQE 534
           LL    AN+ A       T L LA   G   V   L++ GAD    E    TPL  A Q 
Sbjct: 611 LLAESHANMGA-LGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQR 669

Query: 535 GHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQE 587
                V  LL   ANVHA    G T    A   G+T +  VL++AGA LD Q+
Sbjct: 670 STFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQD 722



 Score =  131 bits (330), Expect = 2e-30
 Identities = 110/365 (30%), Positives = 173/365 (47%), Gaps = 6/365 (1%)

Query: 203 SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 262
           + G V  VR LL     V+  T  G + L +A      +L  +LLA H    +R ++   
Sbjct: 371 AQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLA-HGADANRVDEDGW 429

Query: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
            PL  A+  G     +LLL H A V++Q   G T L  A    F ++ ++L++  A+   
Sbjct: 430 APLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNL 489

Query: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382
           H   G TPL  AA  GHV + ++L   GA ++      + + L LA  +G +  ++ LL+
Sbjct: 490 HEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLR-TPLHLAVERGKVRAIQHLLK 548

Query: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 442
           +GA  +      +  L  A   G   + ++LL  GA + +P     +PL LAA  GH+E+
Sbjct: 549 SGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEI 608

Query: 443 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 502
             LL E  AN+  +    +TPL  AAR G E +V+ LL  GA+ NA  E++  T L LA 
Sbjct: 609 IHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNA-AEQSGWTPLHLAV 667

Query: 503 CGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDT 559
                     L++  A++        TP   A+ +G+  ++K L+ +GA +        T
Sbjct: 668 QRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCT 727

Query: 560 ALTYA 564
            L  A
Sbjct: 728 PLQLA 732



 Score =  118 bits (295), Expect = 2e-26
 Identities = 106/355 (29%), Positives = 165/355 (46%), Gaps = 24/355 (6%)

Query: 138 VDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRS 197
           VD +T +    LL AA    P++         CAL  A  A          +A +VD   
Sbjct: 388 VDCQTASGYTPLLIAAQDQQPDL---------CALLLAHGA----------DANRVDEDG 428

Query: 198 LAE---ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVE 254
            A    A  +GD    R LLD G  V+    EG + L LA    +  +A++L++  A+  
Sbjct: 429 WAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPN 488

Query: 255 DRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 314
               +G  TPL  A+  G++ +VKLL    A++++Q     T L  A   G V  ++ LL
Sbjct: 489 LHEAEGK-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLL 547

Query: 315 NEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 374
             GA  +  +++G+ PL  AA+ G   + ++LL +GA +   +++   + L LA YKGHL
Sbjct: 548 KSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ-GWTPLHLAAYKGHL 606

Query: 375 DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLA 434
           +++  L E+ A+         T L  A   G   V   LL  GA  N    S  +PL LA
Sbjct: 607 EIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLA 666

Query: 435 ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ 489
                      L+E  AN+   N  G+TP   AA +G+  ++ +L+  GA ++ Q
Sbjct: 667 VQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721



 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 78/268 (29%), Positives = 124/268 (46%), Gaps = 8/268 (2%)

Query: 324 NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN----EFKESALTLACYKGHLDMVRF 379
           NE+    LM++ S  +++ A  L D    +         E K + L     +G ++ VR 
Sbjct: 321 NEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRL 380

Query: 380 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 439
           LL    D + +T   +T L+ A  D   ++  LLL  GA  N   +   +PL  AA  G 
Sbjct: 381 LLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGD 440

Query: 440 VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALT 499
              A LL++ GA ++    EG+TPL  AA+   E +  LL+++ A+ N   E   +T L 
Sbjct: 441 DGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH-EAEGKTPLH 499

Query: 500 LACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTAT 556
           +A   G   +   L   GA+++       TPL  A + G +  +++LL SGA   A   +
Sbjct: 500 VAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQS 559

Query: 557 GDTALTYACENGHTDVADVLLQAGADLD 584
           G   L  A   G   +  +LL+ GA L+
Sbjct: 560 GYGPLHTAAARGKYLICKMLLRYGASLE 587



 Score = 38.9 bits (89), Expect = 0.014
 Identities = 22/63 (34%), Positives = 35/63 (55%)

Query: 526 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDK 585
           TPL     +G +E V+ LLA   +V   TA+G T L  A ++   D+  +LL  GAD ++
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423

Query: 586 QED 588
            ++
Sbjct: 424 VDE 426


>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 2 [Homo sapiens]
          Length = 1990

 Score =  148 bits (374), Expect = 1e-35
 Identities = 117/364 (32%), Positives = 181/364 (49%), Gaps = 23/364 (6%)

Query: 241  ELAQVLLAMHANVEDRGNKGDITPLMAASSG-GYLDIVKLLLLHDADVNSQSATGNTALT 299
            +++++L+   AN+  R    +  P++   S  GY ++V LLL   A+V++ S +G T L 
Sbjct: 864  KVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLG 923

Query: 300  YACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLD-------HGAG 352
            YA A G++ IV +L  + A ++  ++NG   L+ AA  GH+EV + L+           G
Sbjct: 924  YAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQG 983

Query: 353  INTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEM----------HTALMEAC 402
            +   S+  ++ AL  A   G+ ++V +LL+     E + +             TAL  A 
Sbjct: 984  VFKKSHAIQQ-ALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAA 1042

Query: 403  MDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYT 462
              G +EV RLLL+ GA V  P      PL      GH ++  LL+  GA++   + +G T
Sbjct: 1043 GRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRT 1102

Query: 463  PLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---D 519
            PLM AA EGH   V  LLAQGA+I A  ++   TAL+ AC  G   V   L+  GA    
Sbjct: 1103 PLMMAASEGHLGTVDFLLAQGASI-ALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDH 1161

Query: 520  IELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA 579
             +    TPL  A+  G  E+V++L+  GA +     +G   L  A    +T V   LL+ 
Sbjct: 1162 ADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKK 1221

Query: 580  GADL 583
            GA +
Sbjct: 1222 GAKI 1225



 Score =  144 bits (364), Expect = 2e-34
 Identities = 116/370 (31%), Positives = 171/370 (46%), Gaps = 23/370 (6%)

Query: 206  DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 263
            ++   R L+  G ++N  TE      +LC+    GY E+  +LL   ANV D  ++  +T
Sbjct: 862  NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANV-DASSESGLT 920

Query: 264  PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL-------NE 316
            PL  A++ GYL IV LL    A V+     G  AL +A   G +++VK L+        +
Sbjct: 921  PLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQ 980

Query: 317  GANIEDHNENGHTPLMEAASAGHVEVARVLLD---------HGAGINTHSNEFKESALTL 367
               +   +      L+ AAS G+ E+   LLD           A IN+  + + E+ALT 
Sbjct: 981  QQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTA 1040

Query: 368  ACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 427
            A  +G L++ R LLE GA            L      GH ++  LLL  GA VNM     
Sbjct: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQG 1100

Query: 428  ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 487
             +PL +AA  GH+     L+ +GA++  ++ EG T L  A  +GH  +V  L+  GA  +
Sbjct: 1101 RTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD 1160

Query: 488  AQTEETQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLL 544
               ++   T L LA   G +EV  FL+  GA IE        PL  A    +  +V  LL
Sbjct: 1161 -HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLL 1219

Query: 545  ASGANVHATT 554
              GA +   T
Sbjct: 1220 KKGAKIGPAT 1229



 Score =  140 bits (352), Expect = 4e-33
 Identities = 109/334 (32%), Positives = 172/334 (51%), Gaps = 26/334 (7%)

Query: 274  LDIVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPL 331
            + + +LL+L  A++N ++   N A  L      G+ ++V +LL  GAN++  +E+G TPL
Sbjct: 863  IKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPL 922

Query: 332  MEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE-----AGAD 386
              AA+AG++ +  +L    A ++ H ++  + AL  A  +GHL++V+FL++     AG  
Sbjct: 923  GYAAAAGYLSIVVLLCKKRAKVD-HLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981

Query: 387  QE--HKTDEMHTALMEACMDGHVEVARLLLD---------SGAQVNMPADSF--ESPLTL 433
            Q    K+  +  AL+ A   G+ E+   LLD           AQ+N   DS   E+ LT 
Sbjct: 982  QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINS-FDSLWGETALTA 1040

Query: 434  AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 493
            AA  G +E+  LL+E+GA + + N  G  PL    R+GH ++V LLL  GA++N   ++ 
Sbjct: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVN-MADKQ 1099

Query: 494  QETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANV 550
              T L +A   G     DFL+  GA I L      T L  A  +GHL +V+ L+ +GA  
Sbjct: 1100 GRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAAT 1159

Query: 551  HATTATGDTALTYACENGHTDVADVLLQAGADLD 584
                  G T L  A   G  +V   L+  GA ++
Sbjct: 1160 DHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1193



 Score =  132 bits (333), Expect = 7e-31
 Identities = 107/364 (29%), Positives = 155/364 (42%), Gaps = 52/364 (14%)

Query: 205  GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 263
            G    V  LL+ G +V+  +E G + L  A +AGY  +  +L    A V+     G    
Sbjct: 896  GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955

Query: 264  --------------------------------------PLMAASSGGYLDIVKLLL---- 281
                                                   L+AA+S GY +IV  LL    
Sbjct: 956  VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE 1015

Query: 282  -----LHDADVNS-QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAA 335
                 +  A +NS  S  G TALT A   G +++ ++LL +GA +   N  G  PL    
Sbjct: 1016 KDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTV 1075

Query: 336  SAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 395
              GH ++  +LL HGA +N    + + + L +A  +GHL  V FLL  GA       E  
Sbjct: 1076 RQGHWQIVDLLLTHGADVNMADKQGR-TPLMMAASEGHLGTVDFLLAQGASIALMDKEGL 1134

Query: 396  TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE 455
            TAL  AC+ GH+ V R L+D+GA  +    +  +PL LAA  G  E+   L++ GA +E 
Sbjct: 1135 TALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEH 1194

Query: 456  VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT--EETQETALTLACCGGFSEVADFL 513
            V+  G  PL  A    +  +V  LL +GA I   T    T +  + +       E  D  
Sbjct: 1195 VDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMF 1254

Query: 514  IKAG 517
             K G
Sbjct: 1255 YKKG 1258



 Score = 36.6 bits (83), Expect = 0.070
 Identities = 34/120 (28%), Positives = 54/120 (45%), Gaps = 9/120 (7%)

Query: 197  SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
            +L+ AC  G ++ VR L+D G + +   + G + L LA   G  E+ Q L+   A +E  
Sbjct: 1136 ALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHV 1195

Query: 257  GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
               G + PL  A       +V  LL   A +           T+A A    DI+ +LL++
Sbjct: 1196 DYSG-MRPLDRAVGCRNTSVVVTLLKKGAKIG--------PATWAMATSKPDIMIILLSK 1246


>gi|67906195 ankyrin repeat and sterile alpha motif domain
           containing 6 [Homo sapiens]
          Length = 871

 Score =  148 bits (373), Expect = 2e-35
 Identities = 144/446 (32%), Positives = 198/446 (44%), Gaps = 61/446 (13%)

Query: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257
           L  AC  GD    R+LL+ G +  E  E G      A  AG            A V   G
Sbjct: 13  LLRACDQGDTETARRLLEPGAA--EPAERGAEPEAGAEPAG------------AEVAGPG 58

Query: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
                    AA++G     V         V+     GNTAL +A AGG   +V+ LL  G
Sbjct: 59  ---------AAAAGAVGAPVP--------VDCSDEAGNTALQFAAAGGHEPLVRFLLRRG 101

Query: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377
           A++   N  G + LM+AA  GHV VA +LLDHGA +N   N    S LT+A   GHL +V
Sbjct: 102 ASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNA-QNRLGASVLTVASRGGHLGVV 160

Query: 378 RFLLEAGA--DQEHKTDEM------------HTALMEACMDGHVEVARLLLDSGAQVNMP 423
           + LLEAGA  D  H + E              TALM A   GH  V RLL++ GA  N  
Sbjct: 161 KLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHA 220

Query: 424 ADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
           A +   SPL LAA  G + +A  L+E+GAN + ++    T    A    H ++V  L   
Sbjct: 221 ARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPL 280

Query: 483 GANINAQTEETQETALTLAC-CGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLE 538
                   EE +   +  A   G F  V +   +  + + L     +TPLM A+  G L 
Sbjct: 281 TTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLA 340

Query: 539 LVKYLLASGANVHATTAT-GDTALTYACENGHTDVADVLLQAGADLDKQE-------DMK 590
           LV+ L+   A+V    +  G TAL  A  +G+ ++   LL  GAD+  +        D+ 
Sbjct: 341 LVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLV 400

Query: 591 TILEGIDPAKHQVRVAFDACKLLRKE 616
            +L   DP    VR+    C  + K+
Sbjct: 401 MLLN--DPDTELVRLLASVCMQVNKD 424


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  146 bits (369), Expect = 5e-35
 Identities = 115/391 (29%), Positives = 191/391 (48%), Gaps = 7/391 (1%)

Query: 194 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 253
           D   L +A    DV  VR LL +  ++N   +E  + L  A   G   + Q+LL   ANV
Sbjct: 8   DQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANV 67

Query: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
             +     +TPL  A++     ++ LLL H ADVN++     T L  A A       + L
Sbjct: 68  NAKDTLW-LTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL 126

Query: 314 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 373
               +++   + +G + L  A  +GH+E   +LL+ GA +N    + ++  L  A + GH
Sbjct: 127 APLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQP-LHWAAFLGH 185

Query: 374 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 433
           L++++ L+  GAD   K  + +  L  A   G +EV + LL  GA+++ P     + L +
Sbjct: 186 LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHI 245

Query: 434 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM-VALLLAQGANINAQTEE 492
           A   G   +A  L+  GAN+ + ND+G+TPL  AA   +  + + LL+  GA++N Q++E
Sbjct: 246 ACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKE 305

Query: 493 TQETALTLACCGGFSEVADFLIKAGADIELG---CSTPLMEASQEGHLELVKYLLASGAN 549
            +      A  G F+  +  LI+ G++I+      +TPL  A++ GH  L+  L+ +GA+
Sbjct: 306 GKSPLHMAAIHGRFTR-SQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD 364

Query: 550 VHATTATGDTALTYACENGHTDVADVLLQAG 580
                      L  A   G +D    LL +G
Sbjct: 365 TARRGIHDMFPLHLAVLFGFSDCCRKLLSSG 395



 Score =  128 bits (321), Expect = 2e-29
 Identities = 132/484 (27%), Positives = 213/484 (44%), Gaps = 25/484 (5%)

Query: 130 AEGADLRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHN 189
           + GADLR  D   +  L       ++     L    + V+ A  +  + L    A +++ 
Sbjct: 444 SSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYR 503

Query: 190 AGQVDTRSLAEACSDGDVNAVRK---------LLDEGRSVNEHTEEGESLLCLACSAGYY 240
             +  T S  +A  D  +   R+         LLD G   +    +G + +  A + G  
Sbjct: 504 RAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNR 563

Query: 241 ELAQVLLAMHAN-VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALT 299
           +  ++LL M  N +ED  +   ++PL  A+  G+ + +K L     +++ +   G TAL 
Sbjct: 564 QNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALF 623

Query: 300 YACAGGFVDIVKVLLNEGAN-IEDHNENGHTPLMEAASAGHVEVARVLLDHG--AGINTH 356
            A   G  + V+VL   GA+ +    +   TPL  AA++GH +   +L+D G  A I   
Sbjct: 624 LATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDV 683

Query: 357 SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS 416
            + + ++ L LA   GH+D V  LLE G+  +       TAL    + G  +    LLD 
Sbjct: 684 MDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDH 743

Query: 417 GAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE----VNDEGYTPLMEAAREGH 472
            A V        +P+ LA+  GH  +   L++   + +     V+  GY+P+  A+  GH
Sbjct: 744 DAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGH 803

Query: 473 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA-GADI----ELGCSTP 527
           E+ + LLL       +  E    T L  A         + L+ A GA I    +    TP
Sbjct: 804 EDCLELLLEHSPF--SYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTP 861

Query: 528 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG-ADLDKQ 586
           L  A+   ++  ++ LL   A V+AT  TG TAL  A ENG T   + LL  G ADL   
Sbjct: 862 LHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVL 921

Query: 587 EDMK 590
           ++ K
Sbjct: 922 DENK 925



 Score =  119 bits (298), Expect = 8e-27
 Identities = 141/563 (25%), Positives = 215/563 (38%), Gaps = 108/563 (19%)

Query: 123 EIFLSSTAEGADLRTVDPETQARLEA-------------LLEAAAFADPEVLRRLTSSVS 169
           E+     A GADL   D +    L               L   A   +P         ++
Sbjct: 187 EVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 246

Query: 170 CALDEAAAALTRMKAENSHNAGQVDTRSLAE----ACSDGDVNAVRKLLDEGRSVNEHTE 225
           C L + A A+  + A    N  Q + +        A S      +  L++ G  VN  ++
Sbjct: 247 CYLGQDAVAIELVNA--GANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSK 304

Query: 226 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL---- 281
           EG+S L +A   G +  +Q+L+   + + D  +K   TPL  A+  G+  ++  L+    
Sbjct: 305 EGKSPLHMAAIHGRFTRSQILIQNGSEI-DCADKFGNTPLHVAARYGHELLISTLMTNGA 363

Query: 282 ------LHDA-----------------------------------------DVNSQSATG 294
                 +HD                                          D+N+    G
Sbjct: 364 DTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLG 423

Query: 295 NTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN 354
            T L  A +GG V+ + +LL+ GA++   ++ G TPL  AA+ G  + A  L+  GAG+N
Sbjct: 424 RTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVN 483

Query: 355 ----------------------------THSNEFKESALTLACYKGHLDMVRFLLEAGAD 386
                                       +H  E ++  L  +  K     + FLL+ GAD
Sbjct: 484 EADCKGCSPLHYAAASDTYRRAEPHTPSSHDAE-EDEPLKESRRKEAFFCLEFLLDNGAD 542

Query: 387 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF--ESPLTLAACGGHVELAA 444
              +  + +TA+  A   G+ +   LLL+         +S    SPL LAA  GH E   
Sbjct: 543 PSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALK 602

Query: 445 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 504
            L E   NL+  + +G T L  A   G  E V +L A GA+   +  + + T L  A   
Sbjct: 603 TLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAAS 662

Query: 505 GFSEVADFLIKAG--ADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGD 558
           G ++    LI +G  ADI    +    TPLM A   GH++ V  LL  G+   A    G 
Sbjct: 663 GHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGR 722

Query: 559 TALTYACENGHTDVADVLLQAGA 581
           TAL      G  D    LL   A
Sbjct: 723 TALHRGAVTGCEDCLAALLDHDA 745



 Score =  110 bits (274), Expect = 5e-24
 Identities = 88/264 (33%), Positives = 127/264 (48%), Gaps = 9/264 (3%)

Query: 330 PLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 389
           PL++A  +  VE  R LL     IN    E + + L  A Y G + +++ LL +GA+   
Sbjct: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQE-RRTPLHAAAYVGDVPILQLLLMSGANVNA 69

Query: 390 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 449
           K     T L  A    + +V  LLL   A VN     +++PL +AA     + A  L   
Sbjct: 70  KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129

Query: 450 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 509
            ++L   +  G + L  A   GH E V LLL +GA++N   ++ +   L  A   G  EV
Sbjct: 130 LSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNV-CDKKERQPLHWAAFLGHLEV 188

Query: 510 ADFLIKAGADIELGCSTP-----LMEASQEGHLELVKYLLASGANVHATTATGDTALTYA 564
              L+  GAD  LGC        L  A+  G +E+VKYLL  GA +    A G+TAL  A
Sbjct: 189 LKLLVARGAD--LGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 246

Query: 565 CENGHTDVADVLLQAGADLDKQED 588
           C  G   VA  L+ AGA++++  D
Sbjct: 247 CYLGQDAVAIELVNAGANVNQPND 270



 Score =  105 bits (262), Expect = 1e-22
 Identities = 116/423 (27%), Positives = 172/423 (40%), Gaps = 50/423 (11%)

Query: 201  ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA------------ 248
            A  +G   A++ L +   +++    +G + L LA   G  E  +VL A            
Sbjct: 592  AAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKR 651

Query: 249  ----MHANVE-----------DRGNKGDIT---------PLMAASSGGYLDIVKLLLLHD 284
                +HA              D G + DIT         PLM A   G++D V LLL   
Sbjct: 652  KWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKG 711

Query: 285  ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 344
            +  ++    G TAL      G  D +  LL+  A +   +  G TP+  A++ GH  V R
Sbjct: 712  STADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLR 771

Query: 345  VLLDHGAG---INTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEA 401
             LL        ++   +    S +  A Y GH D +  LLE  +   +      T L  A
Sbjct: 772  TLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE-HSPFSYLEGNPFTPLHCA 830

Query: 402  CMDGHVEVARLLLDS-GAQ-VNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE 459
             ++       +LL + GA+ VN       +PL  AA   +V    +L++  A +   +  
Sbjct: 831  VINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHT 890

Query: 460  GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD 519
            G T LM AA  G    V  LL +G       +E + TAL LAC  G  + A  ++    D
Sbjct: 891  GRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQD 950

Query: 520  IELGCST------PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVA 573
            + L  +T      PL  A++ G   +V+ LL+ GA V A    G T       N   DVA
Sbjct: 951  LGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPN--KDVA 1008

Query: 574  DVL 576
            D L
Sbjct: 1009 DCL 1011



 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 77/291 (26%), Positives = 111/291 (38%), Gaps = 41/291 (14%)

Query: 198  LAEACSDGDVNAVRKLLDEGRSVNEHTE----EGESLLCLACSAGYYELAQVLLAMHANV 253
            LA AC  G    +R LL    S +         G S +  A   G+ +  ++LL      
Sbjct: 760  LASAC--GHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFS 817

Query: 254  EDRGNKGDITPLMAASSGGYLDIVKLLL--LHDADVNSQSATGNTALTYACAGGFVDIVK 311
               GN    TPL  A         ++LL  L    VNS+ A G T L  A     V  ++
Sbjct: 818  YLEGNP--FTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLR 875

Query: 312  VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 371
            +LL   A +   +  G T LM AA  G       LL  G    T  +E K +AL LAC K
Sbjct: 876  MLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSK 935

Query: 372  GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 431
            GH      +L    D                                 +N    + + PL
Sbjct: 936  GHEKCALMILAETQDL------------------------------GLINATNSALQMPL 965

Query: 432  TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA-REGHEEMVALLLA 481
             +AA  G   +   L+  GA +  V++EG+TP +  A  +   + +AL+L+
Sbjct: 966  HIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILS 1016



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 55/177 (31%), Positives = 82/177 (46%), Gaps = 4/177 (2%)

Query: 253  VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 312
            V  R  KG  TPL AA+    +  +++LL H A+VN+   TG TAL  A   G    V+ 
Sbjct: 851  VNSRDAKGR-TPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEF 909

Query: 313  LLNEG-ANIEDHNENGHTPLMEAASAGHVEVARVLL--DHGAGINTHSNEFKESALTLAC 369
            LL  G A++   +EN +T L  A S GH + A ++L      G+   +N   +  L +A 
Sbjct: 910  LLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAA 969

Query: 370  YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 426
              G   +V+ LL  GA      +E HT  +    +  V     L+ S  +   P D+
Sbjct: 970  RNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILSTMKPFPPKDA 1026



 Score = 35.4 bits (80), Expect = 0.16
 Identities = 33/127 (25%), Positives = 52/127 (40%), Gaps = 31/127 (24%)

Query: 463 PLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL 522
           PL++A      E V  LL+Q  NIN   +E +                            
Sbjct: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERR---------------------------- 42

Query: 523 GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 582
              TPL  A+  G + +++ LL SGANV+A      T L  A  + +  V  +LL   AD
Sbjct: 43  ---TPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSAD 99

Query: 583 LDKQEDM 589
           ++ ++ +
Sbjct: 100 VNARDKL 106


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score =  143 bits (361), Expect = 4e-34
 Identities = 139/437 (31%), Positives = 199/437 (45%), Gaps = 54/437 (12%)

Query: 196 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG--ESLLCLACSAGYYELAQVLLAMHANV 253
           R L EAC +GDV+ V++L+D   +VN     G   S L  A   G  ++ + LL M ANV
Sbjct: 184 RELLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANV 242

Query: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
             R + G + PL  A S G+ ++V LLL   AD N++     T L  A   G +D+  VL
Sbjct: 243 HAR-DDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301

Query: 314 LNEGANIEDHNENGHT--------------------PLMEAASAGHVEVARVLLDHGAGI 353
           L  GA+    N +G +                     L+EAA +G+ E    LL     +
Sbjct: 302 LQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLT-PLNV 360

Query: 354 NTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 412
           N H+++ ++S  L LA     + +V+ LL+ GAD   K       L  AC  GH EV  L
Sbjct: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420

Query: 413 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN-------DEGYTP-- 463
           LL  GA VN       +PL  AA    VE+ +LL+  GA+   VN       D   TP  
Sbjct: 421 LLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL 480

Query: 464 ------------LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG---GFSE 508
                       L++AARE     V   LA    IN +  ++ ETAL  A         +
Sbjct: 481 RERLTYEFKGHSLLQAAREADLAKVKKTLALEI-INFKQPQSHETALHCAVASLHPKRKQ 539

Query: 509 VADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 565
           V + L++ GA++        TPL  A++  H ++++ L   GA ++A    G TAL  A 
Sbjct: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAA 599

Query: 566 ENGHTDVADVLLQAGAD 582
             GH     +LL  G+D
Sbjct: 600 LAGHLQTCRLLLSYGSD 616



 Score =  132 bits (331), Expect = 1e-30
 Identities = 139/494 (28%), Positives = 205/494 (41%), Gaps = 84/494 (17%)

Query: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSA------GYYELAQVLLAMHA 251
           L EA   G ++    LL  G   N    +G+S L LA  +      G Y+  ++L A  +
Sbjct: 286 LHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARS 345

Query: 252 NVEDR----------------GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGN 295
             E++                G K   TPL  A+    + IV+LLL H ADV+++   G 
Sbjct: 346 GNEEKLMALLTPLNVNCHASDGRKS--TPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGL 403

Query: 296 TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG--- 352
             L  AC+ G  ++ ++LL  GA +   +    TPL EAAS   VEV  +LL HGA    
Sbjct: 404 VPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTL 463

Query: 353 INTHSN-----------------EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 395
           +N H                   EFK  +L  A  +  L  V+  L        +     
Sbjct: 464 VNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHE 523

Query: 396 TALMEACMDGHV---EVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAN 452
           TAL  A    H    +V  LLL  GA VN     F +PL +AA   H ++  +L + GA 
Sbjct: 524 TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK 583

Query: 453 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA------------------------ 488
           +  ++  G T L  AA  GH +   LLL+ G++ +                         
Sbjct: 584 MNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSEST 643

Query: 489 --QTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTPLMEASQEGHLELVKYL 543
             +T +     L  +  G    V            D+E   STPL  A+    + +V+YL
Sbjct: 644 PIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYL 703

Query: 544 LASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK--TILEGIDPAKH 601
           L  GA+VHA    G   L  AC  GH +VA++L++ GA ++  +  K   + E     K+
Sbjct: 704 LHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKY 763

Query: 602 QVRVAFDACKLLRK 615
           ++      CKLL K
Sbjct: 764 EI------CKLLLK 771



 Score =  131 bits (329), Expect = 2e-30
 Identities = 129/441 (29%), Positives = 199/441 (45%), Gaps = 59/441 (13%)

Query: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV---LLAMHANV 253
           SL +A  + D+  V+K L       +  +  E+ L  A ++ + +  QV   LL   ANV
Sbjct: 492 SLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANV 551

Query: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
            ++ NK  +TPL  A+   + D++++L  H A +N+    G TAL  A   G +   ++L
Sbjct: 552 NEK-NKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLL 610

Query: 314 LNEGANIEDHNENGHTP--------------------------LMEAASAGHVEVARVLL 347
           L+ G++    +  G T                           L+EA+ AG +E  + L 
Sbjct: 611 LSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLC 670

Query: 348 DHGAGINTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGH 406
                +N    E + S  L  A     + +V +LL  GAD   K       L  AC  GH
Sbjct: 671 S-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGH 729

Query: 407 VEVARLLLDSGAQVNMPADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 465
            EVA LL+  GA VN+ AD ++ +PL  AA  G  E+  LL++ GA+  + N +G TPL 
Sbjct: 730 YEVAELLVRHGASVNV-ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPL- 787

Query: 466 EAAREGHEEMVALLLAQGA--------------------NINAQ-TEETQETALTLACCG 504
           +  +EG  ++  LL    A                    NIN + T+    T L LA   
Sbjct: 788 DLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGY 847

Query: 505 GFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561
              EVA++L++ GAD+   + G   PL  A+  GH+++   L+     V+AT     T L
Sbjct: 848 NNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 907

Query: 562 TYACENGHTDVADVLLQAGAD 582
             A + G T +  +LL  GAD
Sbjct: 908 HEAAQKGRTQLCALLLAHGAD 928



 Score =  112 bits (279), Expect = 1e-24
 Identities = 104/314 (33%), Positives = 153/314 (48%), Gaps = 25/314 (7%)

Query: 209 AVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG-DITPLMA 267
           AV+++L E   +   T + +  L  A  AG  E  + L +   NV  R  +G   TPL  
Sbjct: 634 AVQQILSESTPIR--TSDVDYRLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHF 690

Query: 268 ASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG 327
           A+    + +V+ LL H ADV+++   G   L  AC+ G  ++ ++L+  GA++   +   
Sbjct: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750

Query: 328 HTPLMEAASAGHVEVARVLLDHGAGI-------NTHSNEFKE------------SALTLA 368
            TPL EAA+ G  E+ ++LL HGA         NT  +  KE            +AL  A
Sbjct: 751 FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDA 810

Query: 369 CYKGHLDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSF 427
             KG L  V+ L          T   + T L  A    ++EVA  LL+ GA VN      
Sbjct: 811 AKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGG 870

Query: 428 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 487
             PL  AA  GHV++AALLI+    +   +   +TPL EAA++G  ++ ALLLA GA+  
Sbjct: 871 LIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPT 930

Query: 488 AQTEETQETALTLA 501
            + +E Q T L LA
Sbjct: 931 MKNQEGQ-TPLDLA 943



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 34/114 (29%), Positives = 52/114 (45%), Gaps = 5/114 (4%)

Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
           A    ++     LL+ G  VN   + G   L  A S G+ ++A +L+  +  V +  +K 
Sbjct: 844 AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCV-NATDKW 902

Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 314
             TPL  A+  G   +  LLL H AD   ++  G T L  A A    D ++ LL
Sbjct: 903 AFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA----DDIRALL 952


>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 2 [Homo sapiens]
          Length = 1390

 Score =  142 bits (359), Expect = 7e-34
 Identities = 119/363 (32%), Positives = 182/363 (50%), Gaps = 26/363 (7%)

Query: 241  ELAQVLLAMHANVEDRGNKGDITPLMAASSG-GYLDIVKLLLLHDADVNSQSATGNTALT 299
            +++++L+   ANV  R    +  P++   S  G+ ++V LLL   A ++  S  G TAL 
Sbjct: 906  KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 965

Query: 300  YACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLL---------DHG 350
            YA A G + +V +L  +G  ++  ++ G   L+ +A  GH ++ + LL           G
Sbjct: 966  YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1025

Query: 351  AGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK-----TDEM--HTALMEACM 403
                +H+    + ALT A   GH  +V+ LL  G ++EH+     TD +   TAL  A  
Sbjct: 1026 TLRKSHA---LQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTLWGETALTAAAG 1080

Query: 404  DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 463
             G +EV  LLL  GA V+        PL  AA  GH ++  LL+ERG ++   + +G TP
Sbjct: 1081 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1140

Query: 464  LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL- 522
            LM AA EGH   V  LL++GA +++  +E   +AL+ AC  G   V  +L++ GA I+  
Sbjct: 1141 LMVAACEGHLSTVEFLLSKGAALSSLDKEGL-SALSWACLKGHRAVVQYLVEEGAAIDQT 1199

Query: 523  --GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 580
                 TPL  A+  G  E V YL+  GA +     +G   L  A    +T V   LL+ G
Sbjct: 1200 DKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKG 1259

Query: 581  ADL 583
            A L
Sbjct: 1260 AKL 1262



 Score =  131 bits (330), Expect = 2e-30
 Identities = 117/389 (30%), Positives = 177/389 (45%), Gaps = 26/389 (6%)

Query: 206  DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 263
            +V   R L+  G +VN  TE      +LC+    G+ E+  +LL   A ++     G +T
Sbjct: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG-MT 962

Query: 264  PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL----NEGAN 319
             L  A++ G++ +V LL      V+     G  AL ++   G  DI++ LL    + G  
Sbjct: 963  ALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1022

Query: 320  IEDHNENGHT---PLMEAASAGHVEVARVLL----DHGAGINTHSNEFKESALTLACYKG 372
                    H     L  AAS GH  V + LL    +H   +N     + E+ALT A  +G
Sbjct: 1023 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1082

Query: 373  HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 432
             L++   LL  GA            L  A   GH ++ RLLL+ G  VN+      +PL 
Sbjct: 1083 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1142

Query: 433  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492
            +AAC GH+     L+ +GA L  ++ EG + L  A  +GH  +V  L+ +GA I+ QT++
Sbjct: 1143 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID-QTDK 1201

Query: 493  TQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGAN 549
               T L LA   G +E   +L++ GA IE        PL  A    +  +V  LL  GA 
Sbjct: 1202 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1261

Query: 550  VHATTATGDTALTYACENGHTDVADVLLQ 578
            +      G+ A  +A      D+  +LLQ
Sbjct: 1262 L------GNAA--WAMATSKPDILIILLQ 1282



 Score =  129 bits (323), Expect = 1e-29
 Identities = 96/326 (29%), Positives = 146/326 (44%), Gaps = 45/326 (13%)

Query: 205  GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 263
            G    V  LL+ G  ++  +E G + LC A +AG+ +L  +L      V+    KG    
Sbjct: 938  GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997

Query: 264  --------------------------------------PLMAASSGGYLDIVKLLL---- 281
                                                   L AA+S G+  +V+ LL    
Sbjct: 998  VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1057

Query: 282  LHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 340
             H+ +VN + +  G TALT A   G +++ ++LL  GA +   N  G  PL  AA  GH 
Sbjct: 1058 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1117

Query: 341  EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 400
            ++ R+LL+ G  +N    + +   +  AC +GHL  V FLL  GA       E  +AL  
Sbjct: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAAC-EGHLSTVEFLLSKGAALSSLDKEGLSALSW 1176

Query: 401  ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 460
            AC+ GH  V + L++ GA ++    +  +PL LAA  G  E    L+E+GA +E V+  G
Sbjct: 1177 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1236

Query: 461  YTPLMEAAREGHEEMVALLLAQGANI 486
              PL  A    +  +V  LL +GA +
Sbjct: 1237 MRPLDRAIGCRNTSVVVALLRKGAKL 1262



 Score =  128 bits (321), Expect = 2e-29
 Identities = 98/326 (30%), Positives = 160/326 (49%), Gaps = 46/326 (14%)

Query: 276  IVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLME 333
            + +LL+L  A+VN ++   N A  L      G  ++V +LL  GA ++  +ENG T L  
Sbjct: 907  VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 966

Query: 334  AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA----GADQE- 388
            AA+AGH+++  +L   G  ++ H ++  + AL  +  +GH D++++LL      G  Q  
Sbjct: 967  AAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1025

Query: 389  --HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGGHVE 441
               K+  +  AL  A   GH  V + LL    +  +  +       E+ LT AA  G +E
Sbjct: 1026 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1085

Query: 442  LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
            +  LL+  GA +   N  G  PL  AAR+GH ++V LLL +G ++N   ++ +       
Sbjct: 1086 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR------- 1138

Query: 502  CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561
                                    TPLM A+ EGHL  V++LL+ GA + +    G +AL
Sbjct: 1139 ------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL 1174

Query: 562  TYACENGHTDVADVLLQAGADLDKQE 587
            ++AC  GH  V   L++ GA +D+ +
Sbjct: 1175 SWACLKGHRAVVQYLVEEGAAIDQTD 1200



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 42/162 (25%), Positives = 70/162 (43%), Gaps = 4/162 (2%)

Query: 162  RRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRS---LAEACSDGDVNAVRKLLDEGR 218
            RR    + CA  +    + R+  E   +    D +    L  A  +G ++ V  LL +G 
Sbjct: 1102 RRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGA 1161

Query: 219  SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVK 278
            +++   +EG S L  AC  G+  + Q L+   A + D+ +K   TPL  A+  G  + V 
Sbjct: 1162 ALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAI-DQTDKNGRTPLDLAAFYGDAETVL 1220

Query: 279  LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
             L+   A +     +G   L  A       +V  LL +GA +
Sbjct: 1221 YLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1262


>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 1 [Homo sapiens]
          Length = 1861

 Score =  142 bits (359), Expect = 7e-34
 Identities = 119/363 (32%), Positives = 182/363 (50%), Gaps = 26/363 (7%)

Query: 241  ELAQVLLAMHANVEDRGNKGDITPLMAASSG-GYLDIVKLLLLHDADVNSQSATGNTALT 299
            +++++L+   ANV  R    +  P++   S  G+ ++V LLL   A ++  S  G TAL 
Sbjct: 914  KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 973

Query: 300  YACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLL---------DHG 350
            YA A G + +V +L  +G  ++  ++ G   L+ +A  GH ++ + LL           G
Sbjct: 974  YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1033

Query: 351  AGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK-----TDEM--HTALMEACM 403
                +H+    + ALT A   GH  +V+ LL  G ++EH+     TD +   TAL  A  
Sbjct: 1034 TLRKSHA---LQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTLWGETALTAAAG 1088

Query: 404  DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 463
             G +EV  LLL  GA V+        PL  AA  GH ++  LL+ERG ++   + +G TP
Sbjct: 1089 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1148

Query: 464  LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL- 522
            LM AA EGH   V  LL++GA +++  +E   +AL+ AC  G   V  +L++ GA I+  
Sbjct: 1149 LMVAACEGHLSTVEFLLSKGAALSSLDKEGL-SALSWACLKGHRAVVQYLVEEGAAIDQT 1207

Query: 523  --GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 580
                 TPL  A+  G  E V YL+  GA +     +G   L  A    +T V   LL+ G
Sbjct: 1208 DKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKG 1267

Query: 581  ADL 583
            A L
Sbjct: 1268 AKL 1270



 Score =  131 bits (330), Expect = 2e-30
 Identities = 117/389 (30%), Positives = 177/389 (45%), Gaps = 26/389 (6%)

Query: 206  DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 263
            +V   R L+  G +VN  TE      +LC+    G+ E+  +LL   A ++     G +T
Sbjct: 912  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG-MT 970

Query: 264  PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL----NEGAN 319
             L  A++ G++ +V LL      V+     G  AL ++   G  DI++ LL    + G  
Sbjct: 971  ALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1030

Query: 320  IEDHNENGHT---PLMEAASAGHVEVARVLL----DHGAGINTHSNEFKESALTLACYKG 372
                    H     L  AAS GH  V + LL    +H   +N     + E+ALT A  +G
Sbjct: 1031 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1090

Query: 373  HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 432
             L++   LL  GA            L  A   GH ++ RLLL+ G  VN+      +PL 
Sbjct: 1091 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1150

Query: 433  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492
            +AAC GH+     L+ +GA L  ++ EG + L  A  +GH  +V  L+ +GA I+ QT++
Sbjct: 1151 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID-QTDK 1209

Query: 493  TQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGAN 549
               T L LA   G +E   +L++ GA IE        PL  A    +  +V  LL  GA 
Sbjct: 1210 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1269

Query: 550  VHATTATGDTALTYACENGHTDVADVLLQ 578
            +      G+ A  +A      D+  +LLQ
Sbjct: 1270 L------GNAA--WAMATSKPDILIILLQ 1290



 Score =  129 bits (323), Expect = 1e-29
 Identities = 96/326 (29%), Positives = 146/326 (44%), Gaps = 45/326 (13%)

Query: 205  GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 263
            G    V  LL+ G  ++  +E G + LC A +AG+ +L  +L      V+    KG    
Sbjct: 946  GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005

Query: 264  --------------------------------------PLMAASSGGYLDIVKLLL---- 281
                                                   L AA+S G+  +V+ LL    
Sbjct: 1006 VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1065

Query: 282  LHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 340
             H+ +VN + +  G TALT A   G +++ ++LL  GA +   N  G  PL  AA  GH 
Sbjct: 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1125

Query: 341  EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 400
            ++ R+LL+ G  +N    + +   +  AC +GHL  V FLL  GA       E  +AL  
Sbjct: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAAC-EGHLSTVEFLLSKGAALSSLDKEGLSALSW 1184

Query: 401  ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 460
            AC+ GH  V + L++ GA ++    +  +PL LAA  G  E    L+E+GA +E V+  G
Sbjct: 1185 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1244

Query: 461  YTPLMEAAREGHEEMVALLLAQGANI 486
              PL  A    +  +V  LL +GA +
Sbjct: 1245 MRPLDRAIGCRNTSVVVALLRKGAKL 1270



 Score =  128 bits (321), Expect = 2e-29
 Identities = 98/326 (30%), Positives = 160/326 (49%), Gaps = 46/326 (14%)

Query: 276  IVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLME 333
            + +LL+L  A+VN ++   N A  L      G  ++V +LL  GA ++  +ENG T L  
Sbjct: 915  VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 974

Query: 334  AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA----GADQE- 388
            AA+AGH+++  +L   G  ++ H ++  + AL  +  +GH D++++LL      G  Q  
Sbjct: 975  AAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1033

Query: 389  --HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGGHVE 441
               K+  +  AL  A   GH  V + LL    +  +  +       E+ LT AA  G +E
Sbjct: 1034 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1093

Query: 442  LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
            +  LL+  GA +   N  G  PL  AAR+GH ++V LLL +G ++N   ++ +       
Sbjct: 1094 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR------- 1146

Query: 502  CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561
                                    TPLM A+ EGHL  V++LL+ GA + +    G +AL
Sbjct: 1147 ------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL 1182

Query: 562  TYACENGHTDVADVLLQAGADLDKQE 587
            ++AC  GH  V   L++ GA +D+ +
Sbjct: 1183 SWACLKGHRAVVQYLVEEGAAIDQTD 1208



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 42/162 (25%), Positives = 70/162 (43%), Gaps = 4/162 (2%)

Query: 162  RRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRS---LAEACSDGDVNAVRKLLDEGR 218
            RR    + CA  +    + R+  E   +    D +    L  A  +G ++ V  LL +G 
Sbjct: 1110 RRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGA 1169

Query: 219  SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVK 278
            +++   +EG S L  AC  G+  + Q L+   A + D+ +K   TPL  A+  G  + V 
Sbjct: 1170 ALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAI-DQTDKNGRTPLDLAAFYGDAETVL 1228

Query: 279  LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
             L+   A +     +G   L  A       +V  LL +GA +
Sbjct: 1229 YLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1270


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  142 bits (359), Expect = 7e-34
 Identities = 129/440 (29%), Positives = 205/440 (46%), Gaps = 57/440 (12%)

Query: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY---YELAQVLLAMHANV 253
           SL +A  + DV  ++K L       +H +  E+ L  A ++ Y    ++ ++LL   AN+
Sbjct: 334 SLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANI 393

Query: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
            ++  K  +TPL  AS   + D+V++++ H+A VN+    G T+L  A   G +   ++L
Sbjct: 394 NEK-TKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452

Query: 314 LNEGAN-----------IEDHNENGHTPLMEAASAGHVEVARVLLDHGAG---------- 352
           L+ G +           ++  NEN    L E  S G+ E  R LL+              
Sbjct: 453 LSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLC 512

Query: 353 ----INTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 407
               +N    E ++S  L  A     + +V +LL+ GAD   K       L  AC  GH 
Sbjct: 513 TVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHY 572

Query: 408 EVARLLLDSGAQVNMPADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLME 466
           EVA LL+  GA VN+ AD ++ +PL  AA  G  E+  LL++ GA+  + N +G TPL +
Sbjct: 573 EVAELLVKHGAVVNV-ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL-D 630

Query: 467 AAREGHEEMVALLLAQGA--------------------NINAQ-TEETQETALTLACCGG 505
             ++G  ++  LL    A                    N+N + T+    T L LA    
Sbjct: 631 LVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYN 690

Query: 506 FSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 562
             EVA++L++ GAD+   + G   PL  A+  GH+++   L+   A V+AT     T L 
Sbjct: 691 NLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLH 750

Query: 563 YACENGHTDVADVLLQAGAD 582
            A + G T +  +LL  GAD
Sbjct: 751 EAAQKGRTQLCALLLAHGAD 770



 Score =  139 bits (351), Expect = 6e-33
 Identities = 133/437 (30%), Positives = 198/437 (45%), Gaps = 54/437 (12%)

Query: 196 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY--YELAQVLLAMHANV 253
           R L EAC +GDV  V++L+     VN     G     L  +AG+   ++ + LL   ANV
Sbjct: 26  RELFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANV 84

Query: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
           + R + G + PL  A S G+ ++V LLL H AD N++     T L  A   G +D+  VL
Sbjct: 85  QAR-DDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVL 143

Query: 314 LNEGANIEDHNENGHT--------------------PLMEAASAGHVEVARVLLDHGAGI 353
           L  GA     N +G T                     L+E+A +G+ E    LL     +
Sbjct: 144 LQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLT-PLNV 202

Query: 354 NTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 412
           N H+++ ++S  L LA     + +V+ LL+ GAD   K       L  AC  GH EV  L
Sbjct: 203 NCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTEL 262

Query: 413 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN-------DEGYTP-- 463
           L+  GA VN       +PL  AA    VE+ +LL+  GA+   +N       D   TP  
Sbjct: 263 LVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQL 322

Query: 464 ------------LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGF---SE 508
                       L++AARE     +   L+    +N +  +T ETAL  A    +    +
Sbjct: 323 KERLAYEFKGHSLLQAAREADVTRIKKHLSL-EMVNFKHPQTHETALHCAAASPYPKRKQ 381

Query: 509 VADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 565
           + + L++ GA+I        TPL  AS++ H ++V+ ++   A V+A    G T+L  A 
Sbjct: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441

Query: 566 ENGHTDVADVLLQAGAD 582
             GH     +LL  G D
Sbjct: 442 YCGHLQTCRLLLSYGCD 458



 Score =  120 bits (301), Expect = 4e-27
 Identities = 106/302 (35%), Positives = 147/302 (48%), Gaps = 19/302 (6%)

Query: 196 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV--LLAMHANV 253
           R L EA   GDV  V+KL    +SVN    EG     L  +AGY  ++ V  LL   A+V
Sbjct: 494 RQLLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552

Query: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
             + +KG + PL  A S G+ ++ +LL+ H A VN       T L  A A G  +I K+L
Sbjct: 553 HAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLL 611

Query: 314 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 373
           L  GA+    N +G+TPL +    G  ++  +L               ++AL  A  KG 
Sbjct: 612 LQHGADPTKKNRDGNTPL-DLVKDGDTDIQDLLRG-------------DAALLDAAKKGC 657

Query: 374 LDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 432
           L  V+ L          T   H T L  A    ++EVA  LL  GA VN        PL 
Sbjct: 658 LARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLH 717

Query: 433 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492
            AA  GHV++AALLI+  A +   +   +TPL EAA++G  ++ ALLLA GA+   + +E
Sbjct: 718 NAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQE 777

Query: 493 TQ 494
            Q
Sbjct: 778 GQ 779



 Score =  119 bits (298), Expect = 8e-27
 Identities = 126/455 (27%), Positives = 199/455 (43%), Gaps = 49/455 (10%)

Query: 191 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY--YELAQVLLA 248
           G+     L E+   G+   +  LL    +VN H  +G     L  +AGY   ++ Q+LL 
Sbjct: 174 GEYKKDELLESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQ 232

Query: 249 MHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVD 308
             A+V  + +KGD+ PL  A S G+ ++ +LL+ H A VN+      T L  A +   V+
Sbjct: 233 HGADVHAK-DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVE 291

Query: 309 IVKVLLNEGAN---IEDHNEN-------------------GHTPLMEAASAGHVEVARVL 346
           +  +LL+ GA+   +  HN++                   GH+ L  A  A    + + L
Sbjct: 292 VCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHL 351

Query: 347 LDHGAGINTHSNEFKESALTLAC---YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 403
                 +N    +  E+AL  A    Y     +   LL  GA+   KT E  T L  A  
Sbjct: 352 SLEM--VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASE 409

Query: 404 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 463
             H +V  +++   A+VN   +  ++ L  AA  GH++   LL+  G +   ++ +G+T 
Sbjct: 410 KAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTA 469

Query: 464 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DI 520
           L         E V  LL +G ++     E     L  A  G    V            DI
Sbjct: 470 LQMG-----NENVQQLLQEGISLG--NSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDI 522

Query: 521 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 580
           E   STPL  A+    + +V+YLL  GA+VHA    G   L  AC  GH +VA++L++ G
Sbjct: 523 EGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHG 582

Query: 581 ADLDKQEDMK--TILEGIDPAKHQVRVAFDACKLL 613
           A ++  +  K   + E     K+++      CKLL
Sbjct: 583 AVVNVADLWKFTPLHEAAAKGKYEI------CKLL 611



 Score =  100 bits (250), Expect = 3e-21
 Identities = 152/594 (25%), Positives = 221/594 (37%), Gaps = 131/594 (22%)

Query: 113 LDNPVLKTTSEIFLSSTAEGAD--LRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSC 170
           L    +K   ++ +     GA+  +R  D  T   L      A          L  S   
Sbjct: 128 LHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARS 187

Query: 171 ALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESL 230
             +E   AL      N H +    +  L  A     V  V+ LL  G  V  H ++   L
Sbjct: 188 GNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADV--HAKDKGDL 245

Query: 231 LCL--ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLH----- 283
           + L  ACS G+YE+ + LL  H    +  +    TPL  A+S   +++  LLL +     
Sbjct: 246 VPLHNACSYGHYEVTE-LLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPT 304

Query: 284 ------------------------------------DADVN-------------SQSATG 294
                                               +ADV                  T 
Sbjct: 305 LLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTH 364

Query: 295 NTALTYACAGGFV---DIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 351
            TAL  A A  +     I ++LL +GANI +  +   TPL  A+   H +V  V++ H A
Sbjct: 365 ETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEA 424

Query: 352 GINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVAR 411
            +N   N   +++L  A Y GHL   R LL  G D    + +  TAL      G+  V +
Sbjct: 425 KVNALDN-LGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQM----GNENVQQ 479

Query: 412 LLLDSGAQVNMPADSFESPLTLAACGGHVE-LAALLIERGANLEEVNDEGYTPLMEAARE 470
           LL +  +  N  AD     L  AA  G VE +  L   +  N  ++     TPL  AA  
Sbjct: 480 LLQEGISLGNSEADR---QLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGY 536

Query: 471 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTP 527
               +V  LL  GA+++A+ ++     L  AC  G  EVA+ L+K GA +   +L   TP
Sbjct: 537 NRVSVVEYLLQHGADVHAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTP 595

Query: 528 LMEASQEGHLELVKYLLASGA-----NVHATTAT---------------GDTALTYACEN 567
           L EA+ +G  E+ K LL  GA     N    T                 GD AL  A + 
Sbjct: 596 LHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKK 655

Query: 568 G----------------------------------HTDVADVLLQAGADLDKQE 587
           G                                  + +VA+ LLQ GAD++ Q+
Sbjct: 656 GCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQD 709



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 91/321 (28%), Positives = 133/321 (41%), Gaps = 26/321 (8%)

Query: 147 EALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGD 206
           + L E  +  + E  R+L  +      E    L  +++ N  +     +  L  A     
Sbjct: 479 QLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNR 538

Query: 207 VNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLM 266
           V+ V  LL  G  V+   + G   L  ACS G+YE+A+ LL  H  V +  +    TPL 
Sbjct: 539 VSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAE-LLVKHGAVVNVADLWKFTPLH 597

Query: 267 AASSGGYLDIVKLLLLHDADVNSQSATGNT--------------------ALTYACAGGF 306
            A++ G  +I KLLL H AD   ++  GNT                    AL  A   G 
Sbjct: 598 EAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGC 657

Query: 307 VDIVKVLLN-EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 365
           +  VK L + +  N  D      TPL  AA   ++EVA  LL HGA +N           
Sbjct: 658 LARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLH 717

Query: 366 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 425
             A Y GH+D+   L++  A          T L EA   G  ++  LLL  GA   +   
Sbjct: 718 NAASY-GHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQ 776

Query: 426 SFESPLTLAACGGHVELAALL 446
             ++PL L +     +++ALL
Sbjct: 777 EGQTPLDLVSAD---DVSALL 794



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 64/215 (29%), Positives = 95/215 (44%), Gaps = 26/215 (12%)

Query: 398 LMEACMDGHVE-VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEV 456
           L EAC +G VE V RL+          A    +PL  AA  G  ++   L++ GAN++  
Sbjct: 28  LFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR 87

Query: 457 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA 516
           +D G  PL  A   GH E+V LLL  GA+ NA+ +    T L  A   G  +V   L++ 
Sbjct: 88  DDGGLIPLHNACSFGHAEVVNLLLRHGADPNAR-DNWNYTPLHEAAIKGKIDVCIVLLQH 146

Query: 517 GAD---------IELGCSTP--------------LMEASQEGHLELVKYLLAS-GANVHA 552
           GA+           L  + P              L+E+++ G+ E +  LL     N HA
Sbjct: 147 GAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHA 206

Query: 553 TTATGDTALTYACENGHTDVADVLLQAGADLDKQE 587
           +     T L  A       +  +LLQ GAD+  ++
Sbjct: 207 SDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKD 241



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 27/64 (42%), Positives = 40/64 (62%)

Query: 525 STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
           STPL  A+  G  ++V+YLL +GANV A    G   L  AC  GH +V ++LL+ GAD +
Sbjct: 59  STPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPN 118

Query: 585 KQED 588
            +++
Sbjct: 119 ARDN 122



 Score = 37.7 bits (86), Expect = 0.031
 Identities = 28/88 (31%), Positives = 40/88 (45%), Gaps = 5/88 (5%)

Query: 502 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLA-SGANVHATTATGDTA 560
           C GG +  A     A A+     +  L EA + G +E VK L+     N   T     T 
Sbjct: 6   CAGGGAACAS----AAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTP 61

Query: 561 LTYACENGHTDVADVLLQAGADLDKQED 588
           L +A   G  DV + LLQ GA++  ++D
Sbjct: 62  LHFAAGFGRKDVVEYLLQNGANVQARDD 89


>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
           sapiens]
          Length = 587

 Score =  140 bits (353), Expect = 3e-33
 Identities = 105/371 (28%), Positives = 174/371 (46%), Gaps = 10/371 (2%)

Query: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257
           L +A  DGD  A++ ++ EG+++ E  +EG   L  A   G     +VL   +    D+ 
Sbjct: 61  LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120

Query: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
              + T +  A+  G+LD +  LL   A+ +  + +  T L  AC     + VK+L+   
Sbjct: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180

Query: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377
           A+       G T L E+ S   +EV ++L+  GA + +  N +  + L +A   G L+ +
Sbjct: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVES-KNAYGITPLFVAAQSGQLEAL 239

Query: 378 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 437
           RFL + GAD   +  +  +AL EAC + H EV   LL  GA  N        PL +A+  
Sbjct: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299

Query: 438 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT------- 490
           G+  +  +L+    +   +   G +PL  AA   H+E++  LL+   ++N          
Sbjct: 300 GNYRIVQMLLP-VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358

Query: 491 -EETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGAN 549
            E+ + +AL  A         + L++ GAD      +PL+ A + G L  ++ LL  GAN
Sbjct: 359 YEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGAN 418

Query: 550 VHATTATGDTA 560
           + A  AT  TA
Sbjct: 419 IDAYIATHPTA 429



 Score =  103 bits (258), Expect = 4e-22
 Identities = 92/329 (27%), Positives = 148/329 (44%), Gaps = 45/329 (13%)

Query: 298 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 357
           L  A   G  + +K ++ EG N+ + N+ G  PL EAA  G V   +VL     G     
Sbjct: 61  LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120

Query: 358 NEFKESALTLACYKGHLDMVRFLLEAGADQE---------------------------HK 390
              +E+A+ LA  +GHLD +  LL+AGA+ +                           H 
Sbjct: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180

Query: 391 TDEMH------TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 444
            D  H      TAL E+     +EV ++L+  GA+V        +PL +AA  G +E   
Sbjct: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALR 240

Query: 445 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 504
            L + GA++     +  + L EA +  HEE+V  LL+QGA+ N +T +     L +A   
Sbjct: 241 FLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADAN-KTNKDGLLPLHIASKK 299

Query: 505 GFSEVADFLIKAGADIELGCS--TPLMEASQEGHLELVKYLLASGANVHATTA------- 555
           G   +   L+   +   +  S  +PL  A++  H E+++ LL++  +V+   A       
Sbjct: 300 GNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLY 359

Query: 556 --TGDTALTYACENGHTDVADVLLQAGAD 582
                +AL +A  N +    ++LLQ GAD
Sbjct: 360 EDRRSSALYFAVVNNNVYATELLLQHGAD 388



 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 63/225 (28%), Positives = 105/225 (46%), Gaps = 5/225 (2%)

Query: 365 LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS-GAQVNMP 423
           L  A   G  + ++ +++ G +      E    L EA   G V   ++L  +    ++  
Sbjct: 61  LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120

Query: 424 ADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG 483
               E+ + LA C GH++    L++ GA  +  N    TPL +A    + E V +L+   
Sbjct: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180

Query: 484 ANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELV 540
           A+ N +      TAL  +      EV   L+  GA +E   +   TPL  A+Q G LE +
Sbjct: 181 ADTNHRCNRGW-TALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239

Query: 541 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDK 585
           ++L   GA+++   +   +AL  AC+N H +V + LL  GAD +K
Sbjct: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANK 284



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 52/167 (31%), Positives = 78/167 (46%), Gaps = 7/167 (4%)

Query: 423 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
           PAD    PL  A   G  E    +I+ G NL E N EG+ PL EAA  G    + +L   
Sbjct: 57  PAD----PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRA 112

Query: 483 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLEL 539
                 Q    +ETA+ LA C G  +    L++AGA+ ++      TPL +A +  + E 
Sbjct: 113 YPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEA 172

Query: 540 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQ 586
           VK L+   A+ +     G TAL  +      +V  +L+  GA ++ +
Sbjct: 173 VKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESK 219


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score =  127 bits (320), Expect = 2e-29
 Identities = 89/304 (29%), Positives = 149/304 (49%), Gaps = 5/304 (1%)

Query: 282 LHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVE 341
           L + DVN  +  G   L  A   G + I+++L+  G+ I+  ++ G   +  AA  GHV+
Sbjct: 367 LSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVD 426

Query: 342 VARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEA 401
             + L ++   ++   ++  E AL +A   GH D+ + L   G++   +  E  T L  A
Sbjct: 427 TLKFLSENKCPLDV-KDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCA 485

Query: 402 CMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGY 461
              G+  VA+ L ++G  VN+     E+PL  A+  G+ ++   L E GA+L   + +G+
Sbjct: 486 AWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGH 545

Query: 462 TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIE 521
             L  A R    E++  LL+QG  ++ Q +    T L +AC  G   +   L +A  +++
Sbjct: 546 IALHLAVRRCQMEVIKTLLSQGCFVDYQ-DRHGNTPLHVACKDGNMPIVVALCEANCNLD 604

Query: 522 LGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 578
           +      TPL  A+  G L++V+YL   GA+V A T  G TA   A    H  VA +L +
Sbjct: 605 ISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLAR 664

Query: 579 AGAD 582
              D
Sbjct: 665 LRKD 668



 Score =  117 bits (292), Expect = 4e-26
 Identities = 82/269 (30%), Positives = 135/269 (50%), Gaps = 5/269 (1%)

Query: 319 NIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVR 378
           ++   N++G  PL+ AA  G++++ ++L+  G+ I+   ++   +A+  A   GH+D ++
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQ-DKGGSNAVYWAARHGHVDTLK 429

Query: 379 FLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG 438
           FL E     + K      AL  A   GH +VA+LL   G+  N+     E+PL  AA  G
Sbjct: 430 FLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHG 489

Query: 439 HVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETAL 498
           +  +A  L E G N+   N EG TPL+ A+  G+ ++V  L   GA++NA  ++    AL
Sbjct: 490 YYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNA-CDKDGHIAL 548

Query: 499 TLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTA 555
            LA      EV   L+  G  ++      +TPL  A ++G++ +V  L  +  N+  +  
Sbjct: 549 HLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNK 608

Query: 556 TGDTALTYACENGHTDVADVLLQAGADLD 584
            G T L  A  NG  DV   L   GA ++
Sbjct: 609 YGRTPLHLAANNGILDVVRYLCLMGASVE 637



 Score =  116 bits (290), Expect = 7e-26
 Identities = 94/330 (28%), Positives = 154/330 (46%), Gaps = 5/330 (1%)

Query: 196 RSLAEACSDGDVNAVRKLLDE--GRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 253
           +++  A +D +V  ++ LL       VN+  + G   L +A   G  ++ Q+L+   + +
Sbjct: 346 KAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRI 405

Query: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
            D  +KG    +  A+  G++D +K L  +   ++ +  +G  AL  A   G  D+ ++L
Sbjct: 406 -DVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLL 464

Query: 314 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 373
            + G+N    ++   TPL  AA  G+  VA+ L + G  +N  + E  E+ L  A  +G+
Sbjct: 465 CSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNRE-GETPLLTASARGY 523

Query: 374 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 433
            D+V  L E GAD      + H AL  A     +EV + LL  G  V+       +PL +
Sbjct: 524 HDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHV 583

Query: 434 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 493
           A   G++ +   L E   NL+  N  G TPL  AA  G  ++V  L   GA++ A T + 
Sbjct: 584 ACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTD- 642

Query: 494 QETALTLACCGGFSEVADFLIKAGADIELG 523
            +TA  LA       VA  L +   D   G
Sbjct: 643 GKTAEDLARSEQHEHVAGLLARLRKDTHRG 672



 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 59/193 (30%), Positives = 98/193 (50%), Gaps = 4/193 (2%)

Query: 398 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN 457
           L+ A   G++++ +LL+  G+++++      + +  AA  GHV+    L E    L+  +
Sbjct: 383 LLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKD 442

Query: 458 DEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAG 517
             G   L  AAR GH ++  LL + G+N N Q +E +ET L  A   G+  VA  L +AG
Sbjct: 443 KSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKE-EETPLHCAAWHGYYSVAKALCEAG 501

Query: 518 ADIELGC---STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVAD 574
            ++ +      TPL+ AS  G+ ++V+ L   GA+++A    G  AL  A      +V  
Sbjct: 502 CNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIK 561

Query: 575 VLLQAGADLDKQE 587
            LL  G  +D Q+
Sbjct: 562 TLLSQGCFVDYQD 574



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 31/110 (28%), Positives = 55/110 (50%), Gaps = 7/110 (6%)

Query: 485 NINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVK 541
           ++N   +      L  A CG   ++   LIK G+ I++   G S  +  A++ GH++ +K
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNI-QILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLK 429

Query: 542 YLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD---LDKQED 588
           +L  +   +     +G+ AL  A   GH DVA +L   G++    DK+E+
Sbjct: 430 FLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEE 479


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.130    0.366 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,440,681
Number of Sequences: 37866
Number of extensions: 1166941
Number of successful extensions: 18546
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 499
Number of HSP's successfully gapped in prelim test: 257
Number of HSP's that attempted gapping in prelim test: 6985
Number of HSP's gapped (non-prelim): 4647
length of query: 616
length of database: 18,247,518
effective HSP length: 108
effective length of query: 508
effective length of database: 14,157,990
effective search space: 7192258920
effective search space used: 7192258920
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.