BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|45643138 kelch-like 13 [Homo sapiens] (655 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|45643138 kelch-like 13 [Homo sapiens] 1342 0.0 gi|24308181 kelch-like 9 [Homo sapiens] 1181 0.0 gi|8922854 kelch-like 26 [Homo sapiens] 471 e-132 gi|31542246 kelch-like 36 [Homo sapiens] 420 e-117 gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo... 379 e-105 gi|55741643 kelch-like 14 [Homo sapiens] 356 4e-98 gi|156616301 kelch-like 32 [Homo sapiens] 343 3e-94 gi|24432026 kelch-like [Homo sapiens] 341 1e-93 gi|226442729 kelch-like 15 [Homo sapiens] 311 2e-84 gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 300 3e-81 gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 300 3e-81 gi|40807500 kelch-like 20 [Homo sapiens] 283 5e-76 gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 282 6e-76 gi|23397572 kelch-like 34 [Homo sapiens] 276 4e-74 gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 273 4e-73 gi|55925604 kelch-like 18 [Homo sapiens] 270 2e-72 gi|166235129 kelch-like 3 [Homo sapiens] 268 2e-71 gi|14780904 kelch-like 1 protein [Homo sapiens] 267 3e-71 gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 266 4e-71 gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 266 4e-71 gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 261 1e-69 gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 261 1e-69 gi|38194229 kelch-like 17 [Homo sapiens] 254 2e-67 gi|11056006 kelch-like 12 [Homo sapiens] 248 2e-65 gi|148664209 kelch-like 10 [Homo sapiens] 242 9e-64 gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 234 2e-61 gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 234 2e-61 gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 221 1e-57 gi|40018614 DRE1 protein [Homo sapiens] 221 1e-57 gi|109150407 kelch-like 6 [Homo sapiens] 218 2e-56 >gi|45643138 kelch-like 13 [Homo sapiens] Length = 655 Score = 1342 bits (3473), Expect = 0.0 Identities = 655/655 (100%), Positives = 655/655 (100%) Query: 1 MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQS 60 MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQS Sbjct: 1 MPLKWKTSSPAIWKFPVPVLKTSRSTPLSPAYISLVEEEDQHMKLSLGGSEMGLSSHLQS 60 Query: 61 SKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFK 120 SKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFK Sbjct: 61 SKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFK 120 Query: 121 AMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVL 180 AMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVL Sbjct: 121 AMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVL 180 Query: 181 DFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERL 240 DFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERL Sbjct: 181 DFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERL 240 Query: 241 AFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVD 300 AFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVD Sbjct: 241 AFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVD 300 Query: 301 FMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELR 360 FMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELR Sbjct: 301 FMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELR 360 Query: 361 MYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK 420 MYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK Sbjct: 361 MYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK 420 Query: 421 WMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYG 480 WMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYG Sbjct: 421 WMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYG 480 Query: 481 HAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVI 540 HAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVI Sbjct: 481 HAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVI 540 Query: 541 GGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNR 600 GGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNR Sbjct: 541 GGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNR 600 Query: 601 CMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 655 CMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP Sbjct: 601 CMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP 655 >gi|24308181 kelch-like 9 [Homo sapiens] Length = 617 Score = 1181 bits (3056), Expect = 0.0 Identities = 569/613 (92%), Positives = 594/613 (96%) Query: 43 MKLSLGGSEMGLSSHLQSSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTD 102 MK+SLG EMG+S+HLQ KAG TR FTSNTHSSVVLQGFDQLR+EGLLCDVTL+PGD D Sbjct: 1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGD 60 Query: 103 DAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMD 162 + FPVHR MMASASDYFKAMFTGGMKEQDLMCIKLHGV+KVGL+KIIDFIYTAKLSLNMD Sbjct: 61 EIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMD 120 Query: 163 NLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKN 222 NLQDTLEAASFLQILPVLDFCKVFLISGV+LDNCVEVGRIANTYNL EVDKYVN+F+LKN Sbjct: 121 NLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKN 180 Query: 223 FPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNI 282 FPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKA CRWLRLE+PRMD+AAKLMKNI Sbjct: 181 FPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNI 240 Query: 283 RFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHL 342 RFPLMTPQ+LINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSD+THL Sbjct: 241 RFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHL 300 Query: 343 VTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDT 402 VTLGGVLRQQLVVSKELRMYDE+A EW+SLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDT Sbjct: 301 VTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDT 360 Query: 403 KGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYN 462 KGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKG+LYAVGGR+AAGEL TVECYN Sbjct: 361 KGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYN 420 Query: 463 PRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMT 522 PR NEW+YVAKMSEPHYGHAGTVYGG+MYISGGITHDTFQ ELMCFDPDTDKW+QKAPMT Sbjct: 421 PRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMT 480 Query: 523 TVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGV 582 TVRGLHCMCTVG++LYVIGGNHFRGTSDYDDVLSCEYYSP LDQWTPIAAMLRGQSDVGV Sbjct: 481 TVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGV 540 Query: 583 AVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEET 642 AVFENKIYVVGGYSWNNRCMVEIVQKYDP+KDEWHKVFDLPESLGGIRACTLTVFPPEE Sbjct: 541 AVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEEN 600 Query: 643 TPSPSRESPLSAP 655 SPSRESPLSAP Sbjct: 601 PGSPSRESPLSAP 613 >gi|8922854 kelch-like 26 [Homo sapiens] Length = 615 Score = 471 bits (1211), Expect = e-132 Identities = 249/574 (43%), Positives = 354/574 (61%), Gaps = 8/574 (1%) Query: 69 FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMK 128 F++ +HS+ +LQG LR +G L DV L +AFP H+V++A+ SDYF+AMFTGGM+ Sbjct: 40 FSAPSHSTSLLQGLATLRAQGQLLDVVLTINR--EAFPAHKVVLAACSDYFRAMFTGGMR 97 Query: 129 EQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLI 188 E I+L GVS GLR IIDF Y+A+++L++D +QD L AA FLQ+LPV++ C+ FL Sbjct: 98 EASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLK 157 Query: 189 SGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNS 248 + ++++ C+ +G++A T++L + + V++F ++F + +FL+LP ERL F L SN Sbjct: 158 AAMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNR 217 Query: 249 LKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTC 308 L+ C E++LF+A RWL+ + R A+ ++ +IRFPLM EL++ VQT+D M D C Sbjct: 218 LQSCAEIDLFRAAVRWLQHDPARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLC 277 Query: 309 VNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVL---RQQLVVSKELRMYDEK 365 LLEA NYQ++P+ Q MQS RTA+RSD LVT GG + V SK ++ + Sbjct: 278 RQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPG 337 Query: 366 AHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVA 425 A ++ L M+ +AV+ NF+YV GGQ G+ AVD +R+DP N+W+++ Sbjct: 338 ARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQ 397 Query: 426 SLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTV 485 ++ E R F L+ L G +YA GGRN AG L +VE Y PR NEW Y + +GHAG Sbjct: 398 AMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAA 457 Query: 486 YGGVMYISGGITHDTFQKE-LMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNH 544 GG +YISGG K+ L C+DP D+W KAPM+ R LH M G R+Y +GG Sbjct: 458 SGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRM 517 Query: 545 FRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVE 604 + DVL+ EYY P DQWT ++ M GQS+ G + E KIY+VGGY+W + Sbjct: 518 DHVDRCF-DVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTG 576 Query: 605 IVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFP 638 IVQ Y+ D DEW + PES GI AC + P Sbjct: 577 IVQVYNTDTDEWERDLHFPESFAGI-ACAPVLLP 609 >gi|31542246 kelch-like 36 [Homo sapiens] Length = 616 Score = 420 bits (1079), Expect = e-117 Identities = 221/585 (37%), Positives = 353/585 (60%), Gaps = 13/585 (2%) Query: 66 TRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTG 125 ++++ HSS VLQ ++ RL GL CDV L+ + P HR ++A SDYF +MFT Sbjct: 20 SKVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADE--QRVPAHRNLLAVCSDYFNSMFTI 77 Query: 126 GMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKV 185 GM+E ++L G S +GL+ ++DF+Y +L L+ N+ LE A LQI V+DFC Sbjct: 78 GMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCE 137 Query: 186 FLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLK-LPFERLAFVL 244 +L V+ DN + + +A+ Y+L +D +++ F+L +F L T +FL+ + ++L L Sbjct: 138 YLEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYL 197 Query: 245 SSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTV--DFM 302 SS+ ++ E +L +A +WL + R A ++++NI FPL+ +L++ V+ + Sbjct: 198 SSSEVQRECEHDLLQAALQWLTQQPEREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLL 257 Query: 303 RTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQ-LVVSKELRM 361 + C + EA Y QPVMQ+ RTA+R++ L+ +GG + ++ L +S + Sbjct: 258 PKEANCEGFIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSDDTCY 317 Query: 362 YDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 421 D K+ +W P+ A R H +AV+G F+++ GG + D G A + ++R+DPR +W Sbjct: 318 LDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQW 377 Query: 422 MQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGH 481 ++VAS+N++R F+L++++ L A+GGRN G L +VE Y+P+T+ W+YVA + YGH Sbjct: 378 IKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGH 437 Query: 482 AGTVYGGVMYISGGITHD----TFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERL 537 AGT+Y +YISGG HD ++K L+C+D TD W ++ PMTT RG H MC++G+ + Sbjct: 438 AGTIYKDFVYISGG--HDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSI 495 Query: 538 YVIGGNHFRGTS-DYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYS 596 Y IGG+ S + DVL E YSP +QWT +A +L S+ GVAV+E +IY++GGYS Sbjct: 496 YSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYS 555 Query: 597 WNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEE 641 W N + VQ YD + D+W + DLP+++ G AC + P E Sbjct: 556 WENTAFSKTVQVYDREADKWSRGVDLPKAIAGGSACVCALEPRPE 600 >gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo sapiens] Length = 634 Score = 379 bits (973), Expect = e-105 Identities = 210/613 (34%), Positives = 333/613 (54%), Gaps = 25/613 (4%) Query: 48 GGSEMG-LSSHLQSSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFP 106 GG+ + +SS L + GP +L+G ++R E LCD+ + G +F Sbjct: 39 GGNGLSCISSELTDASYGPN-----------LLEGLSKMRQENFLCDLVI--GTKTKSFD 85 Query: 107 VHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQD 166 VH+ +MAS S+YF + K+ + + L+ +S +GL +I + YT KL+L++ + Sbjct: 86 VHKSVMASCSEYFYNILK---KDPSIQRVDLNDISPLGLATVIAYAYTGKLTLSLYTIGS 142 Query: 167 TLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPAL 226 + AA +LQI ++ C FLI ++++NC+ V IA TY+L F+ NF Sbjct: 143 IISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEF 202 Query: 227 LSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPL 286 + +F+KL FE++ +L + L+ +E+ F+ +WL ++ R+ +AA L+ NIRF Sbjct: 203 AESDQFMKLTFEQINELLIDDDLQLPSEIVAFQIAMKWLEFDQKRVKYAADLLSNIRFGT 262 Query: 287 MTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLG 346 ++ Q+L+NYVQ+V M D C LL++A NY ++PY Q +QS RT IR LVT+G Sbjct: 263 ISAQDLVNYVQSVPRMMQDADCHRLLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVG 322 Query: 347 GVLRQQLVVSKELR--MYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKG 404 G R L R +Y + + W L M A + +AV+ FLYV GG+ D + Sbjct: 323 G--RPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARN 380 Query: 405 --KTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYN 462 K AV R+DPR+N W+ +AS+N+KRT F LS G +YA GGRNA G L ++ECY Sbjct: 381 QAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYV 440 Query: 463 PRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMT 522 P TN+W + HA V G + ++GG + + + + +DP +D W + ++ Sbjct: 441 PSTNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLS 500 Query: 523 TVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGV 582 T RG HC T+ +R+YV+GG+ + DVL+ E YSP QW+ A + G S GV Sbjct: 501 TPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGV 560 Query: 583 AVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEET 642 + + Y+VGG++ + + +Q + P+ +EW + +LPE+ G+ CTL++ P Sbjct: 561 SALHGRAYLVGGWNEGEKKYKKCIQCFSPELNEWTEDDELPEATVGVSCCTLSM--PNNV 618 Query: 643 TPSPSRESPLSAP 655 T S S P Sbjct: 619 TRESRASSVSSVP 631 >gi|55741643 kelch-like 14 [Homo sapiens] Length = 628 Score = 356 bits (913), Expect = 4e-98 Identities = 214/633 (33%), Positives = 327/633 (51%), Gaps = 68/633 (10%) Query: 61 SKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFK 120 S++G +HS +L G + L + L CDVTL F H+ ++AS S YF+ Sbjct: 2 SRSGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTA--QGQQFHCHKAVLASCSQYFR 59 Query: 121 AMFT------GGMKEQD------------------------------------------- 131 ++F+ GG+ QD Sbjct: 60 SLFSSHPPLGGGVGGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSP 119 Query: 132 --LMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLIS 189 + + L G S +GLR +++++YTA ++L++D +++ L + L I V C FL Sbjct: 120 RAINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLND 179 Query: 190 GVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSL 249 +++ N +V +IA + L E K N ++++ + L L FE + +L S Sbjct: 180 QISVQNYKQVCKIAALHGLEETKKLANKYLVE---------DVLLLNFEEMRALLDSLPP 230 Query: 250 KHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTC 308 +EL LF+ + WL + E RM +A LMK +RF L+ EL+ VQ+VDFMRTD C Sbjct: 231 PVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVC 290 Query: 309 VNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLR-QQLVVSKELRMYDEKAH 367 LLL+A NY +MP+ Q QS + IRS+ L+ +GG+ + S ++ YD++ Sbjct: 291 QKLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKK 350 Query: 368 EWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASL 427 WK L M H + + NFL+V+GG+ ++ GK + + V R+DPR+N W+Q+ + Sbjct: 351 TWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPM 410 Query: 428 NEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYG 487 E+R F+ L +LY +GGRN G L +VECYN TNEW YV+ + +P HAG V+ Sbjct: 411 QERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHN 470 Query: 488 GVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRG 547 G +YISGG+ + + L C+DP D W +K M T R +H + + +RLY IGGNH +G Sbjct: 471 GKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKG 530 Query: 548 TSDYDDVLSCEYYSPILDQWTPI-AAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIV 606 S + DV+ E Y P DQW + +L G+S G AV ++ IY+VGGYSW+ Sbjct: 531 FS-HLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSST 589 Query: 607 QKYDPDKDEWHKV-FDLPESLGGIRACTLTVFP 638 Y P+K W ++ D+ E L G AC + P Sbjct: 590 ICYCPEKGTWTELEGDVAEPLAG-PACVTVILP 621 >gi|156616301 kelch-like 32 [Homo sapiens] Length = 620 Score = 343 bits (880), Expect = 3e-94 Identities = 214/586 (36%), Positives = 322/586 (54%), Gaps = 23/586 (3%) Query: 67 RIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGG 126 R+ S +H+ VL +Q R +G+LCD+TL+ + F H+ ++A+ SDYF+AMF+ Sbjct: 17 RLCHSESHNDSVLAALNQQRSDGILCDITLIA--EEQKFHAHKAVLAACSDYFRAMFSLC 74 Query: 127 MKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVF 186 M E + LHGV+ +GL++ ++F YT ++ L +QD L A S LQ+L +L+ C + Sbjct: 75 MVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHY 134 Query: 187 LISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLST--GEFLKLPFERLAFVL 244 LI + N +++ R+A+ +NLT ++K V F++K+ LL + E L LP+ L VL Sbjct: 135 LIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVL 194 Query: 245 SSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRT 304 S+ L +E ++++ RWL + +L++ IRF LM L + ++ Sbjct: 195 KSDRLTSLSEEQIWQLAVRWLE-HNCHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQA 253 Query: 305 DNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDE 364 T L+ EA Y Y QPV Q+ RT R + L +GG R+ V KELR ++ Sbjct: 254 SETATALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKV-KELRYFNP 312 Query: 365 KAHE---------WKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFD 415 E W LAPM R H +AV+G+FL+V GG+ + + AV T R+D Sbjct: 313 VDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYD 372 Query: 416 PRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGE-LPTVECYNPRTNEWTYVAKM 474 PR N W ++A + R F L A++ YLYAVGGRN + LPTVE Y P+ N+WT+V Sbjct: 373 PRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSF 432 Query: 475 SEPHYGHAGTVYGGVMYISGGITHDT-FQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTV 533 HAG V G+++ISGG+T+ +Q LM ++P+ +KWI ++PM R H M V Sbjct: 433 DRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAV 492 Query: 534 GERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPI-AAMLRGQSDVGVAVFENKIYVV 592 +LYV+GGN +D V + Y+ DQWT +L GQ++ GVAV +IY+V Sbjct: 493 QRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLV 552 Query: 593 GGYS-WNNRCMVEIVQKYDPDKDEWHKVF---DLPESLGGIRACTL 634 GGYS W N + +Q D ++ +VF LP + GI AC L Sbjct: 553 GGYSIWTNEPLA-CIQVLDVSREGKEEVFYGPTLPFASNGIAACFL 597 >gi|24432026 kelch-like [Homo sapiens] Length = 634 Score = 341 bits (874), Expect = 1e-93 Identities = 205/596 (34%), Positives = 323/596 (54%), Gaps = 22/596 (3%) Query: 69 FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMK 128 + S HS +L+G LR G+L DV L+ HR+++A++ DYF+ MF GG+K Sbjct: 27 YRSAQHSQALLRGLLALRDSGILFDVVLVVEGRH--IEAHRILLAASCDYFRGMFAGGLK 84 Query: 129 EQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLI 188 E + + +HGVS + +I+ FIYT++L L++ N+Q+TL AA LQI ++ FC FL+ Sbjct: 85 EMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLM 144 Query: 189 SGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNS 248 S V +N ++V R+A ++L+ + + +++++LKNF A T ++ +LP E++ +LSSN Sbjct: 145 SWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNR 204 Query: 249 LKHCTELELFKATCRW-LRLEEPRMDFAA-----KLMKNIRFPLMTPQELINYVQTVDFM 302 L+ E E+++ + LE+ + D + KL++ +RFPLM + L +D Sbjct: 205 LEVSCETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDKLDPS 264 Query: 303 RTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGV-LRQQLVVSKELRM 361 +T + L+ Y +QP +QS +T +RSD +V GG+ V+S + + Sbjct: 265 PLRDTVASALM----YHRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQAKY 320 Query: 362 YDEKAHEWKSLAPMDAPRYQH-GIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK 420 + EWK APR + GIAV+ NF+Y++GG +N +G A +R+DPR+N+ Sbjct: 321 LNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNN--VQGFRAESRCWRYDPRHNR 378 Query: 421 WMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYG 480 W Q+ SL ++ + + Y+YAV GR+ +L VE Y+P TN W YVA + Y Sbjct: 379 WFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYA 438 Query: 481 HAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVI 540 HAG G MYI+ G + + KE C+DP ++ W A R H M T+ +LYVI Sbjct: 439 HAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVI 498 Query: 541 GGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNR 600 GG++ DV YS QW+ + + G + G+AV +N+IYV+GG S N Sbjct: 499 GGSN-NDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRG 557 Query: 601 CMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLT-----VFPPEETTPSPSRESP 651 V YD +KD W + L S+ G+ AC LT + P TP S+ P Sbjct: 558 SRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVLTLPRSLLLEPPRGTPDRSQADP 613 >gi|226442729 kelch-like 15 [Homo sapiens] Length = 604 Score = 311 bits (796), Expect = 2e-84 Identities = 191/594 (32%), Positives = 309/594 (52%), Gaps = 27/594 (4%) Query: 63 AGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAM 122 AG F S+ H + V GF L EGLL DVTL+ D F H+ ++A+ SDYF+ M Sbjct: 2 AGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVI--EDHQFQAHKALLATQSDYFRIM 59 Query: 123 FTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDF 182 FT M+E+D I L G++ G ++ F+Y + L+M+ + + L+AA ++Q++ V+ F Sbjct: 60 FTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKF 119 Query: 183 CKVFLISGVTLDNCVEVGRIANTY--NLTEVDKYVNSFVLKNFPALLSTGEFLK-LPFER 239 C FL++ + L+NC E+ R+ + + N+ V + +++F+L NF L+S +FL L FE+ Sbjct: 120 CCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEK 179 Query: 240 LAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTV 299 L L ++ L E+EL++A WLR + R +++NIRF LMTP + V+T Sbjct: 180 LMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTS 239 Query: 300 DFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKEL 359 +F R + +A NY + QP++ + IRS G++ +V SK L Sbjct: 240 EFYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKIL 299 Query: 360 RMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYN 419 + +K W L P +A++ NF++++GG+ A VFR+DPR N Sbjct: 300 LL--KKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQN 357 Query: 420 KWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHY 479 W+Q+A ++ R+ F + + ++YAV GR + E Y+ ++W +V Y Sbjct: 358 SWLQMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKY 417 Query: 480 GHAGTVYGGVMYISGGITHDTFQKELMCFDPD---------------TDKWIQKAPMTTV 524 GH GTV ++I+GGIT + K++ FDP T+ W K+ M Sbjct: 418 GHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYA 477 Query: 525 RGLHCMCTVGERLYVIGG--NHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGV 582 R H M + +LYV GG R + + S E Y+P DQWT +A+M G+S GV Sbjct: 478 RCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGV 537 Query: 583 AVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW--HKVFDLPESLGGIRACTL 634 V + +I V+GG +N I+ +DPD+++W + +P L G++ C L Sbjct: 538 TVLDKQIMVLGGLCYNGHYSDSIL-TFDPDENKWKEDEYPRMPCKLDGLQVCNL 590 >gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] Length = 709 Score = 300 bits (768), Expect = 3e-81 Identities = 194/604 (32%), Positives = 302/604 (50%), Gaps = 19/604 (3%) Query: 37 EEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTL 96 E E S LSS F + H+ + + LCDV L Sbjct: 119 ENESDSSSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVIL 178 Query: 97 MPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAK 156 + GD P HR++++S SDYF AMFT ++E IK+ GV L +I + YT + Sbjct: 179 VAGDR--RIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGR 236 Query: 157 LSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVN 216 L L DN++ L A LQ+ V++ C FL+ + NC+ + A+ T++ K + Sbjct: 237 LELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAH 296 Query: 217 SFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLR--LEEPRMDF 274 ++ +++F ++ EF+ LP +A +L+S+ + E + A W+R LE+ R D Sbjct: 297 NYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDL 356 Query: 275 AAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTA 334 +KL+ IR PL+ PQ L + V F R D C L++EA Y ++P +P++QS RT Sbjct: 357 -SKLLAYIRLPLLAPQFLADMENNVLF-RDDIECQKLIMEAMKYHLLPERRPMLQSPRTK 414 Query: 335 IRSDTT-HLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYV 393 R T L +GG+ + S + YD + + W +A M+ R Q G+AV+ + LYV Sbjct: 415 PRKSTVGTLFAVGGMDSTKGATS--IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYV 472 Query: 394 VGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAG 453 VGG+ G ++TV ++P+ W + ++ R ++ L+G +YAVGG + Sbjct: 473 VGGRD-----GLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS 527 Query: 454 ELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTD 513 L TVE ++P+ +W +VA MS P V G +Y GG + K + CFDP T+ Sbjct: 528 YLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTN 587 Query: 514 KWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSC-EYYSPILDQWTPIAA 572 KW A M+ RG + T LY IGG+ ++ + C E Y P D WT +A+ Sbjct: 588 KWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVAS 647 Query: 573 MLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRAC 632 M + VGV + +K+Y VGGY + + + V+ YDP +EW +V P LG AC Sbjct: 648 MSISRDAVGVCLLGDKLYAVGGY--DGQAYLNTVEAYDPQTNEWTQV--APLCLGRAGAC 703 Query: 633 TLTV 636 +TV Sbjct: 704 VVTV 707 >gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] Length = 755 Score = 300 bits (768), Expect = 3e-81 Identities = 194/604 (32%), Positives = 302/604 (50%), Gaps = 19/604 (3%) Query: 37 EEEDQHMKLSLGGSEMGLSSHLQSSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTL 96 E E S LSS F + H+ + + LCDV L Sbjct: 165 ENESDSSSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVIL 224 Query: 97 MPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAK 156 + GD P HR++++S SDYF AMFT ++E IK+ GV L +I + YT + Sbjct: 225 VAGDR--RIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGR 282 Query: 157 LSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVN 216 L L DN++ L A LQ+ V++ C FL+ + NC+ + A+ T++ K + Sbjct: 283 LELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAH 342 Query: 217 SFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLR--LEEPRMDF 274 ++ +++F ++ EF+ LP +A +L+S+ + E + A W+R LE+ R D Sbjct: 343 NYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDL 402 Query: 275 AAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTA 334 +KL+ IR PL+ PQ L + V F R D C L++EA Y ++P +P++QS RT Sbjct: 403 -SKLLAYIRLPLLAPQFLADMENNVLF-RDDIECQKLIMEAMKYHLLPERRPMLQSPRTK 460 Query: 335 IRSDTT-HLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYV 393 R T L +GG+ + S + YD + + W +A M+ R Q G+AV+ + LYV Sbjct: 461 PRKSTVGTLFAVGGMDSTKGATS--IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYV 518 Query: 394 VGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAG 453 VGG+ G ++TV ++P+ W + ++ R ++ L+G +YAVGG + Sbjct: 519 VGGRD-----GLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS 573 Query: 454 ELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTD 513 L TVE ++P+ +W +VA MS P V G +Y GG + K + CFDP T+ Sbjct: 574 YLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTN 633 Query: 514 KWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSC-EYYSPILDQWTPIAA 572 KW A M+ RG + T LY IGG+ ++ + C E Y P D WT +A+ Sbjct: 634 KWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVAS 693 Query: 573 MLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRAC 632 M + VGV + +K+Y VGGY + + + V+ YDP +EW +V P LG AC Sbjct: 694 MSISRDAVGVCLLGDKLYAVGGY--DGQAYLNTVEAYDPQTNEWTQV--APLCLGRAGAC 749 Query: 633 TLTV 636 +TV Sbjct: 750 VVTV 753 >gi|40807500 kelch-like 20 [Homo sapiens] Length = 609 Score = 283 bits (723), Expect = 5e-76 Identities = 176/572 (30%), Positives = 302/572 (52%), Gaps = 24/572 (4%) Query: 52 MGLSSHLQSSKAGPTRI-FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRV 110 +G + L P R+ + S+ H L+ + LR LCDV L+ G HRV Sbjct: 27 LGDPNKLPEGVPQPARMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKK--IYAHRV 84 Query: 111 MMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEA 170 ++++ S YF+AMFTG + E + + + + + +IDF YT+++++ N+Q L A Sbjct: 85 ILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPA 144 Query: 171 ASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTG 230 A LQ+ + + C FL + NC+ + A+T++ E+ + + F NF ++ + Sbjct: 145 ACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESE 204 Query: 231 EFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTP 289 EF+ LP +L ++SS+ L +E ++F A W++ + R ++++++R PL++P Sbjct: 205 EFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSP 264 Query: 290 QELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDT---THLVTLG 346 + L+ V + +++D C +L+ EA NY ++P +P+MQ RT R L +G Sbjct: 265 KFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVG 324 Query: 347 GVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKT 406 G + S E YD + +EW+ +A M R G++V+ + LY VGG G + Sbjct: 325 GWCSGDAISSVE--RYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHD-----GSS 377 Query: 407 AVDTVFRFDPRYNKW-MQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRT 465 +++V R+DP+ N+W VA + RT ++ L G+LYAVGG++ L VE Y+P+ Sbjct: 378 YLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKE 437 Query: 466 NEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVR 525 N+WT VA MS G A V GG +Y GG + + ++P ++W APM T R Sbjct: 438 NKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGT-R 496 Query: 526 GLHCMCTV-GERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAV 584 H C V + +Y +GG D ++ S E Y+P +QW+P+ AM +S VG+AV Sbjct: 497 RKHLGCAVYQDMIYAVGGR-----DDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAV 551 Query: 585 FENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW 616 ++ VGG+ + ++ ++ +DPD + W Sbjct: 552 VNGQLMAVGGF--DGTTYLKTIEVFDPDANTW 581 Score = 94.0 bits (232), Expect = 4e-19 Identities = 58/182 (31%), Positives = 93/182 (51%), Gaps = 16/182 (8%) Query: 443 LYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQ 502 L+AVGG + + +VE Y+P+TNEW VA MS+ G +V ++Y GG ++ Sbjct: 320 LFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYL 379 Query: 503 KELMCFDPDTDKWIQK-APMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSC---- 557 + +DP T++W AP +T R + +G LY +GG D +SC Sbjct: 380 NSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQ---------DGVSCLNIV 430 Query: 558 EYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWH 617 E Y P ++WT +A+M + V VAV +Y VGG + + V++Y+P ++ WH Sbjct: 431 ERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSP--LNTVERYNPQENRWH 488 Query: 618 KV 619 + Sbjct: 489 TI 490 Score = 71.2 bits (173), Expect = 3e-12 Identities = 40/137 (29%), Positives = 68/137 (49%), Gaps = 22/137 (16%) Query: 362 YDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 421 Y+ + + W ++APM R G AV + +Y VGG+ + T + + R++PR N+W Sbjct: 480 YNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDD-----TTELSSAERYNPRTNQW 534 Query: 422 MQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGH 481 V ++ +R+ L+ + G L AVGG + L T+E ++P N W Sbjct: 535 SPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTW------------- 581 Query: 482 AGTVYGGVMY--ISGGI 496 +YGG+ Y + GG+ Sbjct: 582 --RLYGGMNYRRLGGGV 596 Score = 58.5 bits (140), Expect = 2e-08 Identities = 43/152 (28%), Positives = 73/152 (48%), Gaps = 8/152 (5%) Query: 487 GGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFR 546 G V++ GG + +DP T++W A M+ R + + + LY +GG+ Sbjct: 317 GEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHD-- 374 Query: 547 GTSDYDDVLSCEYYSPILDQWTP-IAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEI 605 G+S + V E Y P +QW+ +A ++ VGVAV +Y VGG + + I Sbjct: 375 GSSYLNSV---ERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQ--DGVSCLNI 429 Query: 606 VQKYDPDKDEWHKVFDLPESLGGIRACTLTVF 637 V++YDP +++W +V + G+ L F Sbjct: 430 VERYDPKENKWTRVASMSTRRLGVAVAVLGGF 461 >gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] Length = 694 Score = 282 bits (722), Expect = 6e-76 Identities = 177/532 (33%), Positives = 280/532 (52%), Gaps = 17/532 (3%) Query: 109 RVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTL 168 R++++S SDYF AMFT ++E IK+ GV L +I + YT +L L DN++ L Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233 Query: 169 EAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLS 228 A LQ+ V++ C FL+ + NC+ + A+ T++ K +++ +++F ++ Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293 Query: 229 TGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLR--LEEPRMDFAAKLMKNIRFPL 286 EF+ LP +A +L+S+ + E + A W+R LE+ R D +KL+ IR PL Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDL-SKLLAYIRLPL 352 Query: 287 MTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTT-HLVTL 345 + PQ L + V F R D C L++EA Y ++P +P++QS RT R T L + Sbjct: 353 LAPQFLADMENNVLF-RDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAV 411 Query: 346 GGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGK 405 GG+ + S + YD + + W +A M+ R Q G+AV+ + LYVVGG+ G Sbjct: 412 GGMDSTKGATS--IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD-----GL 464 Query: 406 TAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRT 465 ++TV ++P+ W + ++ R ++ L+G +YAVGG + L TVE ++P+ Sbjct: 465 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQA 524 Query: 466 NEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVR 525 +W +VA MS P V G +Y GG + K + CFDP T+KW A M+ R Sbjct: 525 RQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRR 584 Query: 526 GLHCMCTVGERLYVIGGNHFRGTSDYDDVLSC-EYYSPILDQWTPIAAMLRGQSDVGVAV 584 G + T LY IGG+ ++ + C E Y P D WT +A+M + VGV + Sbjct: 585 GGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCL 644 Query: 585 FENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTV 636 +K+Y VGGY + + + V+ YDP +EW +V P LG AC +TV Sbjct: 645 LGDKLYAVGGY--DGQAYLNTVEAYDPQTNEWTQV--APLCLGRAGACVVTV 692 >gi|23397572 kelch-like 34 [Homo sapiens] Length = 644 Score = 276 bits (706), Expect = 4e-74 Identities = 190/621 (30%), Positives = 288/621 (46%), Gaps = 70/621 (11%) Query: 74 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLM 133 H +L G+ LR EG LCDVTL ++ FP HR ++A +SDYF+A+F +E Sbjct: 11 HGGALLTGYQALRAEGFLCDVTLETEGSE--FPAHRSLLACSSDYFRALFKSHTQESRAR 68 Query: 134 CIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTL 193 I LH S GL++++DFIYTA LSL+MD ++DTLEAAS+LQ+ L C +L + Sbjct: 69 VIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAP 128 Query: 194 DNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGE----FLKLPFERLAFVLSSNSL 249 +NC +A + L ++ + LL+ G L+L L VL + + Sbjct: 129 ENCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDV 188 Query: 250 KHCTELELFKATCRWLRLE--EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNT 307 E L WLR E R+ +L++ +RF L+ P +++ V + + Sbjct: 189 ARVPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLV-PADVLRRVYSGSGLVLPAR 247 Query: 308 CVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVV------------ 355 L+++A NY P QP+MQ ++T+IRS T ++ +GG +++V+ Sbjct: 248 VKGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARG 307 Query: 356 -------------------------SKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNF 390 ++ + +D H W+SL + P H + GNF Sbjct: 308 QVAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNF 367 Query: 391 LYVVGGQSNYDTKGKTAVD-------TVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYL 443 L+V+GG+S + D V R+DPR++ W +V ++ E R F A+ L Sbjct: 368 LFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERL 427 Query: 444 YAVGGRNAAGE-LPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYG-GVMYISGGIT---- 497 AVGG A GE L +VE Y+ R + WT + +GHAG V GV+YISGG Sbjct: 428 LAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGRGE 487 Query: 498 -HDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLS 556 + ++L P+ W +KAPM T R G + V+ G F Y+ Sbjct: 488 GGASSLRDLYVLGPEEQVWSKKAPMGTAR-------FGHHMAVLRGAVFAFLGRYEPFSE 540 Query: 557 CEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEI--VQKYDPDKD 614 E Y P DQWT + + + G+AV E ++GG W + V V YD D D Sbjct: 541 IERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLD 600 Query: 615 EWHKV-FDLPESLGGIRACTL 634 W + LP + G+R L Sbjct: 601 RWEDIGCALPWAWSGLRCAVL 621 >gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] Length = 718 Score = 273 bits (698), Expect = 4e-73 Identities = 175/569 (30%), Positives = 280/569 (49%), Gaps = 17/569 (2%) Query: 74 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLM 133 H+ L+ + E LCDV L+ G P HR+++++ SDYF AMFT + E Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHL--RIPAHRLVLSAVSDYFAAMFTNDVLEAKQE 221 Query: 134 CIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTL 193 +++ GV L ++ + YT L L D ++ L AA LQ+ V+D C FLI + Sbjct: 222 EVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHP 281 Query: 194 DNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCT 253 NC+ + + TE+ + + +++F ++ EFL LP ++ +L S+ + Sbjct: 282 SNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPD 341 Query: 254 ELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL 312 E +F A +W+ + + R L+ IR PL+ PQ L+ ++T D C LL Sbjct: 342 EETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGDLECQKLL 400 Query: 313 LEASNYQMMPYMQPVMQSDRTAIRSDTT-HLVTLGGVLRQQLVVSKELRMYDEKAHEWKS 371 +EA Y ++P + +MQS RT R T L +GG+ + + + YD + + W Sbjct: 401 MEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGM--DAMKGTTTIEKYDLRTNSWLH 458 Query: 372 LAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKR 431 + M+ R Q G+AVI N LYVVGG+ G ++TV F+P W + ++ R Sbjct: 459 IGTMNGRRLQFGVAVIDNKLYVVGGRD-----GLKTLNTVECFNPVGKIWTVMPPMSTHR 513 Query: 432 TFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMY 491 ++ L+G +YAVGG + L TVE ++P +W YVA MS P +Y Sbjct: 514 HGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLY 573 Query: 492 ISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDY 551 GG + K + FDP T+KW APM+ RG + T LYV+GG+ ++ Sbjct: 574 AIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHC 633 Query: 552 DDVLSC-EYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYD 610 + C E Y P D W+ +A + + V V +K+YVVGGY + + V+ YD Sbjct: 634 SRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY--DGHTYLNTVESYD 691 Query: 611 PDKDEWHKVFDLPESLGGIRACTLTVFPP 639 ++EW + ++P ++G AC + V P Sbjct: 692 AQRNEWKE--EVPVNIGRAGACVVVVKLP 718 >gi|55925604 kelch-like 18 [Homo sapiens] Length = 574 Score = 270 bits (691), Expect = 2e-72 Identities = 178/552 (32%), Positives = 279/552 (50%), Gaps = 21/552 (3%) Query: 83 DQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSK 142 +++R +G LCDVTL GD F HR+++A++ YF AMFT M E I + G+ Sbjct: 29 EEIRRQGKLCDVTLKIGD--HKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDP 86 Query: 143 VGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRI 202 L +I+F Y L+++ N+Q L ASFLQ+ + D C FL + NC+ V + Sbjct: 87 SALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQF 146 Query: 203 ANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATC 262 A T + NSF+ ++F + + EFL LP E + ++S + L +E ++F+A Sbjct: 147 AETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAAL 206 Query: 263 RWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMM 321 W+R + E R + +L+ NIR PL PQ L + VQ D +R + C +L+ EA +Y +M Sbjct: 207 AWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLM 266 Query: 322 PYMQPVMQSDRTAIRSDTT--HLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPR 379 P +P + + RT R T+ L+ G L + ++D A+ W+ PM R Sbjct: 267 PERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTAR 326 Query: 380 YQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSAL 439 + G+AV+ LY +GG YD G+ + TV ++P + W +V S+N KR+ L Sbjct: 327 SRVGVAVVNGLLYAIGG---YD--GQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVL 381 Query: 440 KGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHD 499 G +Y GG + L +VE Y+P T++WT V MS TV+ G +Y+SGG HD Sbjct: 382 DGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGG--HD 439 Query: 500 TFQ--KELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSC 557 Q + ++ T W A M R H ++G +++V GG G + Sbjct: 440 GLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGF-----LSIA 494 Query: 558 EYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWH 617 E YS + DQW I M +S V + ++Y VGGY + + + V+ YDP+ D W Sbjct: 495 EMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGY--DGQSNLSSVEMYDPETDCWT 552 Query: 618 KVFDLPESLGGI 629 + + GG+ Sbjct: 553 FMAPMACHEGGV 564 >gi|166235129 kelch-like 3 [Homo sapiens] Length = 587 Score = 268 bits (684), Expect = 2e-71 Identities = 179/576 (31%), Positives = 286/576 (49%), Gaps = 68/576 (11%) Query: 68 IFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGM 127 I + H + ++LR + LLCDV ++ D + HRV++A+ S YF AMFTG M Sbjct: 26 ITVNPAHMGKAFKVMNELRSKQLLCDVMIVAEDVE--IEAHRVVLAACSPYFCAMFTGDM 83 Query: 128 KEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFL 187 E I++ V L K+ID+IYTA++ + +N+Q L AAS LQ++ V C FL Sbjct: 84 SESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFL 143 Query: 188 ISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSN 247 S + NC+ + A+ + T++ + N++ ++FP ++ EFL L +++ ++SS+ Sbjct: 144 QSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSD 203 Query: 248 SLKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDN 306 L +E ++F+A W+ E E R++ AKLM+++R PL+ L+ V+ ++ +N Sbjct: 204 KLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNN 263 Query: 307 TCVNLLLEASNYQMMPYMQPVM-QSDRTAIRSDTT------------------------- 340 TC + L+EA Y ++P Q ++ ++ RT R+ + Sbjct: 264 TCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFE 323 Query: 341 ------------------------HLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMD 376 H+ +GG V + + +YD +W S+A M Sbjct: 324 EDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRV--RTVDVYDGVKDQWTSIASMQ 381 Query: 377 APRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHL 436 R G AV+ + LY VGG +D G T + +V + + N+W VA +N +R+ + Sbjct: 382 ERRSTLGAAVLNDLLYAVGG---FD--GSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGV 436 Query: 437 SALKGYLYAVGGRNAAGE--LPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISG 494 ++G LYAVGG + A L TVE YNP TNEW YVA MS G V G +Y +G Sbjct: 437 GVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATG 496 Query: 495 GITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDV 554 G +K + +DP T+ W Q A M R +C V LYV+GG+ ++ Sbjct: 497 GHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGD-----DGSCNL 551 Query: 555 LSCEYYSPILDQWTPIAA-MLRGQSDVGVAVFENKI 589 S EYY+P+ D+WT + M G+S GVAV + Sbjct: 552 ASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVIHKSL 587 Score = 82.4 bits (202), Expect = 1e-15 Identities = 58/192 (30%), Positives = 92/192 (47%), Gaps = 8/192 (4%) Query: 438 ALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVY-GGVMYISGGI 496 +L + VGG+ A + +VECY+ + W +A++ AG V+ G +Y GG Sbjct: 298 SLPKVMIVVGGQ-APKAIRSVECYDFEEDRWDQIAELPSRRC-RAGVVFMAGHVYAVGGF 355 Query: 497 THDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLS 556 + + +D D+W A M R + + LY +GG F G++ + S Sbjct: 356 NGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGG--FDGSTG---LAS 410 Query: 557 CEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW 616 E YS ++W +A M +S VGV V E K+Y VGGY +R + V++Y+P +EW Sbjct: 411 VEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEW 470 Query: 617 HKVFDLPESLGG 628 V D+ G Sbjct: 471 IYVADMSTRRSG 482 Score = 40.0 bits (92), Expect = 0.007 Identities = 24/81 (29%), Positives = 34/81 (41%), Gaps = 2/81 (2%) Query: 554 VLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDK 613 + S E Y D+W IA + + GV +Y VGG+ N V V YD K Sbjct: 314 IRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGF--NGSLRVRTVDVYDGVK 371 Query: 614 DEWHKVFDLPESLGGIRACTL 634 D+W + + E + A L Sbjct: 372 DQWTSIASMQERRSTLGAAVL 392 >gi|14780904 kelch-like 1 protein [Homo sapiens] Length = 748 Score = 267 bits (682), Expect = 3e-71 Identities = 180/604 (29%), Positives = 297/604 (49%), Gaps = 29/604 (4%) Query: 44 KLSLGGSEMGLSSHLQSSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDD 103 +LS G M S L SS + + + H+ + + + LCDV L+ G+ Sbjct: 166 RLSSTGHSMTPQSDLDSSSS--EEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRK- 222 Query: 104 AFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDN 163 P HR++++S SDYF AMFT + E IK+ G+ L ++ F YT L L D Sbjct: 223 -IPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDT 281 Query: 164 LQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNF 223 +++ L AA LQ+ V++ C FL+ + NC+ + A+ E+ K +S+ ++N Sbjct: 282 IENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENI 341 Query: 224 PALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNI 282 ++ EFL LP E L +L+S+ + E +F A W++ + + R + + L+ I Sbjct: 342 MEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFI 401 Query: 283 RFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTT-H 341 R PL+ PQ L + ++ + D C L+LEA Y ++P + +MQS RT R T Sbjct: 402 RLPLLPPQILAD-LENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGT 460 Query: 342 LVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYD 401 L +GG+ + + + YD + + W M+ R Q G+AVI + L+V+GG+ Sbjct: 461 LYAVGGMDNNKGATT--IEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRD--- 515 Query: 402 TKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECY 461 G ++TV ++P+ W + ++ R ++ L+G +YAVGG + L TVE + Sbjct: 516 --GLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERW 573 Query: 462 NPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPM 521 +P++ +WT+VA MS G +Y GG + + +DP T+KW APM Sbjct: 574 DPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPM 633 Query: 522 TTVRGLHCMCTVGERLYVIGG------NHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLR 575 RG + T LY +GG NH DY E Y P D WT +A + Sbjct: 634 CKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDY-----VERYDPKTDTWTMVAPLSM 688 Query: 576 GQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLT 635 + VGV + +++Y VGGY + + + ++ YDP +EW ++ L ++G AC + Sbjct: 689 PRDAVGVCLLGDRLYAVGGY--DGQTYLNTMESYDPQTNEWTQMASL--NIGRAGACVVV 744 Query: 636 VFPP 639 + P Sbjct: 745 IKQP 748 >gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] Length = 720 Score = 266 bits (680), Expect = 4e-71 Identities = 169/546 (30%), Positives = 268/546 (49%), Gaps = 15/546 (2%) Query: 74 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLM 133 H+ L+ + E LCDV L+ G P HR+++++ SDYF AMFT + E Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHL--RIPAHRLVLSAVSDYFAAMFTNDVLEAKQE 221 Query: 134 CIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTL 193 +++ GV L ++ + YT L L D ++ L AA LQ+ V+D C FLI + Sbjct: 222 EVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHP 281 Query: 194 DNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCT 253 NC+ + + TE+ + + +++F ++ EFL LP ++ +L S+ + Sbjct: 282 SNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPD 341 Query: 254 ELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL 312 E +F A +W+ + + R L+ IR PL+ PQ L+ ++T D C LL Sbjct: 342 EETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGDLECQKLL 400 Query: 313 LEASNYQMMPYMQPVMQSDRTAIRSDTT-HLVTLGGVLRQQLVVSKELRMYDEKAHEWKS 371 +EA Y ++P + +MQS RT R T L +GG+ + + + YD + + W Sbjct: 401 MEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGM--DAMKGTTTIEKYDLRTNSWLH 458 Query: 372 LAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKR 431 + M+ R Q G+AVI N LYVVGG+ G ++TV F+P W + ++ R Sbjct: 459 IGTMNGRRLQFGVAVIDNKLYVVGGRD-----GLKTLNTVECFNPVGKIWTVMPPMSTHR 513 Query: 432 TFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMY 491 ++ L+G +YAVGG + L TVE ++P +W YVA MS P +Y Sbjct: 514 HGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLY 573 Query: 492 ISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDY 551 GG + K + FDP T+KW APM+ RG + T LYV+GG+ ++ Sbjct: 574 AIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHC 633 Query: 552 DDVLSC-EYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYD 610 + C E Y P D W+ +A + + V V +K+YVVGGY + + V+ YD Sbjct: 634 SRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY--DGHTYLNTVESYD 691 Query: 611 PDKDEW 616 ++EW Sbjct: 692 AQRNEW 697 >gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] Length = 571 Score = 266 bits (680), Expect = 4e-71 Identities = 175/551 (31%), Positives = 277/551 (50%), Gaps = 16/551 (2%) Query: 71 SNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQ 130 ++ HS +LQG + LR LCD+ L GD H+V++AS S YFKAMFTG + E+ Sbjct: 14 THLHSEQLLQGLNLLRQHHELCDIILRVGDVK--IHAHKVVLASVSPYFKAMFTGNLSEK 71 Query: 131 DLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISG 190 + ++ + + L+ I+++ YT + ++ D ++ L AA+ LQI VL C FL S Sbjct: 72 ENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQ 131 Query: 191 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLK 250 + NC+ + R A TY ++ ++ +NF A+ T EF +L L ++S++ L Sbjct: 132 LDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLN 191 Query: 251 HCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCV 309 TE +F A W++ + + R + A+L+ ++R PL++ + L + +R D TC Sbjct: 192 VATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCK 251 Query: 310 NLLLEASNYQMMPYMQPVMQSD-RTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHE 368 +LL EA Y MP + Q+ T R L +GG + MY + Sbjct: 252 HLLNEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGG-KSGLFACLDSVEMYFPQNDS 310 Query: 369 WKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTA---VDTVFRFDPRYNKWMQVA 425 W LAP++ PRY+ GI V+ +YV+GG + G T ++V ++P N W + Sbjct: 311 WIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLE 370 Query: 426 SLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTV 485 +NE R+ + L G LYA+GG + L +VE Y P+ +W VA M+ A V Sbjct: 371 RMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAV 430 Query: 486 YGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHF 545 G++Y GG + +DP D W A M R + + ++V+GG++ Sbjct: 431 LDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHN- 488 Query: 546 RGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEI 605 G S + S E Y P +QWT M ++ VG AV +N +YVVGG+S ++ + Sbjct: 489 -GVS---HLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSS--YLNT 542 Query: 606 VQKYDPDKDEW 616 VQKYDP D W Sbjct: 543 VQKYDPISDTW 553 Score = 112 bits (281), Expect = 8e-25 Identities = 60/193 (31%), Positives = 94/193 (48%), Gaps = 13/193 (6%) Query: 342 LVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYD 401 L LGG Q + S E Y K +W+ +APM R AV+ +Y +GG Sbjct: 388 LYALGGYDGQSYLQSVE--KYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY---- 441 Query: 402 TKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECY 461 G +++V R+DP + W VAS+ +KR F + + G+++ VGG N L ++E Y Sbjct: 442 --GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERY 499 Query: 462 NPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPM 521 +P N+WT M EP G V +Y+ GG + ++ + +DP +D W+ A M Sbjct: 500 DPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGM 559 Query: 522 TTVRGLHCMCTVG 534 ++C C G Sbjct: 560 -----IYCRCNFG 567 Score = 85.1 bits (209), Expect = 2e-16 Identities = 56/191 (29%), Positives = 87/191 (45%), Gaps = 17/191 (8%) Query: 443 LYAVGGRNAAGE-LPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDT- 500 L AVGG++ L +VE Y P+ + W +A ++ P Y V +Y+ GGI + Sbjct: 285 LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVR 344 Query: 501 -------FQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDD 553 + + C++PDT+ W M R + + LY +GG + G S Sbjct: 345 PGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGG--YDGQSYLQS 402 Query: 554 VLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDK 613 V E Y P + +W P+A M +S AV + IY +GGY + V++YDP K Sbjct: 403 V---EKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYG---PAHMNSVERYDPSK 456 Query: 614 DEWHKVFDLPE 624 D W V + + Sbjct: 457 DSWEMVASMAD 467 Score = 55.5 bits (132), Expect = 2e-07 Identities = 31/81 (38%), Positives = 44/81 (54%), Gaps = 5/81 (6%) Query: 359 LRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRY 418 + YD ++W PM PR G AVI N+LYVVGG S G + ++TV ++DP Sbjct: 496 IERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHS-----GSSYLNTVQKYDPIS 550 Query: 419 NKWMQVASLNEKRTFFHLSAL 439 + W+ A + R F L+AL Sbjct: 551 DTWLDSAGMIYCRCNFGLTAL 571 >gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] Length = 597 Score = 261 bits (668), Expect = 1e-69 Identities = 167/553 (30%), Positives = 286/553 (51%), Gaps = 30/553 (5%) Query: 74 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLM 133 H + ++LR + LLCDVT++ D + HRV++A+ S YF AMFTG M E Sbjct: 42 HMKKAFKVMNELRSQNLLCDVTIVAEDME--ISAHRVVLAACSPYFHAMFTGEMSESRAK 99 Query: 134 CIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTL 193 +++ V LR +ID++YTA++ + +N+Q L AA LQ+ V C FL S + Sbjct: 100 RVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 159 Query: 194 DNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCT 253 NC+ + A+ + T++ N++ ++F ++ + EFL L E++ ++SS+ L + Sbjct: 160 VNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISS 219 Query: 254 ELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL 312 E ++F+A W+ + + R +F A+LM+++R PL+ + L+ V+ ++ + C + L Sbjct: 220 EEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYL 279 Query: 313 LEASNYQMMPYMQPV-MQSDRTAIRSDTT---HLVTLGGVLRQQLVVSKELRMYDEKAHE 368 +EA Y ++P Q + M+S RT +R+ +V +GG Q + + YD K Sbjct: 280 IEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG---QAPKAIRSVECYDFKEER 336 Query: 369 WKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLN 428 W +A + + R + G+ + ++ VGG G V TV +DP ++W VA++ Sbjct: 337 WHQVAELPSRRCRAGMVYMAGLVFAVGG-----FNGSLRVRTVDSYDPVKDQWTSVANMR 391 Query: 429 EKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGG 488 ++R+ + L G LYAVGG + + L +VE YN ++NEW +VA M+ V GG Sbjct: 392 DRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGG 451 Query: 489 VMYISGGITHDTFQ--KELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFR 546 ++Y GG + Q + C++ T++W A M+T R + + LY +GG Sbjct: 452 LLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG---- 507 Query: 547 GTSDYDDVL---SCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV 603 +D L S E Y P + W +A M + + GV +YVVGG + C + Sbjct: 508 ----HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGD--DGSCNL 561 Query: 604 EIVQKYDPDKDEW 616 V+ Y+P D+W Sbjct: 562 ASVEYYNPTTDKW 574 Score = 79.7 bits (195), Expect = 8e-15 Identities = 44/122 (36%), Positives = 61/122 (50%), Gaps = 5/122 (4%) Query: 362 YDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 421 Y+ +EW +A M R G+ V+ N LY VGG G +V +DP N W Sbjct: 473 YNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD-----GPLVRKSVEVYDPTTNAW 527 Query: 422 MQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGH 481 QVA +N R + A+ G LY VGG + + L +VE YNP T++WT V+ + Sbjct: 528 RQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSY 587 Query: 482 AG 483 AG Sbjct: 588 AG 589 Score = 74.3 bits (181), Expect = 3e-13 Identities = 53/187 (28%), Positives = 84/187 (44%), Gaps = 7/187 (3%) Query: 443 LYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVY-GGVMYISGGITHDTF 501 L V G A + +VECY+ + W VA++ AG VY G+++ GG Sbjct: 312 LMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRC-RAGMVYMAGLVFAVGGFNGSLR 370 Query: 502 QKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYS 561 + + +DP D+W A M R + LY +GG F G++ V E Y+ Sbjct: 371 VRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGG--FDGSTGLSSV---EAYN 425 Query: 562 PILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFD 621 ++W +A M +S VGV V +Y VGGY +R + V+ Y+ +EW + + Sbjct: 426 IKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAE 485 Query: 622 LPESLGG 628 + G Sbjct: 486 MSTRRSG 492 Score = 38.1 bits (87), Expect = 0.026 Identities = 21/81 (25%), Positives = 36/81 (44%), Gaps = 2/81 (2%) Query: 554 VLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDK 613 + S E Y ++W +A + + G+ ++ VGG+ N V V YDP K Sbjct: 324 IRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGF--NGSLRVRTVDSYDPVK 381 Query: 614 DEWHKVFDLPESLGGIRACTL 634 D+W V ++ + + A L Sbjct: 382 DQWTSVANMRDRRSTLGAAVL 402 >gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] Length = 593 Score = 261 bits (668), Expect = 1e-69 Identities = 167/553 (30%), Positives = 286/553 (51%), Gaps = 30/553 (5%) Query: 74 HSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLM 133 H + ++LR + LLCDVT++ D + HRV++A+ S YF AMFTG M E Sbjct: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDME--ISAHRVVLAACSPYFHAMFTGEMSESRAK 95 Query: 134 CIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTL 193 +++ V LR +ID++YTA++ + +N+Q L AA LQ+ V C FL S + Sbjct: 96 RVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 155 Query: 194 DNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCT 253 NC+ + A+ + T++ N++ ++F ++ + EFL L E++ ++SS+ L + Sbjct: 156 VNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISS 215 Query: 254 ELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL 312 E ++F+A W+ + + R +F A+LM+++R PL+ + L+ V+ ++ + C + L Sbjct: 216 EEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYL 275 Query: 313 LEASNYQMMPYMQPV-MQSDRTAIRSDTT---HLVTLGGVLRQQLVVSKELRMYDEKAHE 368 +EA Y ++P Q + M+S RT +R+ +V +GG Q + + YD K Sbjct: 276 IEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG---QAPKAIRSVECYDFKEER 332 Query: 369 WKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLN 428 W +A + + R + G+ + ++ VGG G V TV +DP ++W VA++ Sbjct: 333 WHQVAELPSRRCRAGMVYMAGLVFAVGG-----FNGSLRVRTVDSYDPVKDQWTSVANMR 387 Query: 429 EKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGG 488 ++R+ + L G LYAVGG + + L +VE YN ++NEW +VA M+ V GG Sbjct: 388 DRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGG 447 Query: 489 VMYISGGITHDTFQ--KELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFR 546 ++Y GG + Q + C++ T++W A M+T R + + LY +GG Sbjct: 448 LLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG---- 503 Query: 547 GTSDYDDVL---SCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV 603 +D L S E Y P + W +A M + + GV +YVVGG + C + Sbjct: 504 ----HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGD--DGSCNL 557 Query: 604 EIVQKYDPDKDEW 616 V+ Y+P D+W Sbjct: 558 ASVEYYNPTTDKW 570 Score = 79.7 bits (195), Expect = 8e-15 Identities = 44/122 (36%), Positives = 61/122 (50%), Gaps = 5/122 (4%) Query: 362 YDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 421 Y+ +EW +A M R G+ V+ N LY VGG G +V +DP N W Sbjct: 469 YNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD-----GPLVRKSVEVYDPTTNAW 523 Query: 422 MQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGH 481 QVA +N R + A+ G LY VGG + + L +VE YNP T++WT V+ + Sbjct: 524 RQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSY 583 Query: 482 AG 483 AG Sbjct: 584 AG 585 Score = 74.3 bits (181), Expect = 3e-13 Identities = 53/187 (28%), Positives = 84/187 (44%), Gaps = 7/187 (3%) Query: 443 LYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVY-GGVMYISGGITHDTF 501 L V G A + +VECY+ + W VA++ AG VY G+++ GG Sbjct: 308 LMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRC-RAGMVYMAGLVFAVGGFNGSLR 366 Query: 502 QKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYS 561 + + +DP D+W A M R + LY +GG F G++ V E Y+ Sbjct: 367 VRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGG--FDGSTGLSSV---EAYN 421 Query: 562 PILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFD 621 ++W +A M +S VGV V +Y VGGY +R + V+ Y+ +EW + + Sbjct: 422 IKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAE 481 Query: 622 LPESLGG 628 + G Sbjct: 482 MSTRRSG 488 Score = 38.1 bits (87), Expect = 0.026 Identities = 21/81 (25%), Positives = 36/81 (44%), Gaps = 2/81 (2%) Query: 554 VLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDK 613 + S E Y ++W +A + + G+ ++ VGG+ N V V YDP K Sbjct: 320 IRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGF--NGSLRVRTVDSYDPVK 377 Query: 614 DEWHKVFDLPESLGGIRACTL 634 D+W V ++ + + A L Sbjct: 378 DQWTSVANMRDRRSTLGAAVL 398 >gi|38194229 kelch-like 17 [Homo sapiens] Length = 642 Score = 254 bits (649), Expect = 2e-67 Identities = 180/598 (30%), Positives = 290/598 (48%), Gaps = 25/598 (4%) Query: 61 SKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFK 120 S+ G + S H ++R GLLCD+ L + H+V++AS S YF Sbjct: 61 SREGHSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKE--IRAHKVVLASCSPYFH 118 Query: 121 AMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVL 180 AMFT M E + LH + L +++ F YTA++ + N+Q L AAS LQ+ V Sbjct: 119 AMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVR 178 Query: 181 DFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERL 240 D C FL+S + NC+ + A+ ++ +++ K + +VL++F + T EF+ LP +++ Sbjct: 179 DACCKFLLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQV 238 Query: 241 AFVLSSNSLKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTV 299 ++SS+SL +E E+++A W++ + + R +LMK +R PL++ L+ +V Sbjct: 239 LELVSSDSLNVPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAE 298 Query: 300 DFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIR---SDTTHLVTLGGVLRQQLVVS 356 +R C +LL+EA + ++P + V+ + RT R L +GG + Sbjct: 299 SLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGG--GSLFAIH 356 Query: 357 KELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDP 416 + YD + W +A M R + G+A +GN LY VGG YD G + + TV +DP Sbjct: 357 GDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGG---YD--GTSDLATVESYDP 411 Query: 417 RYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMS- 475 N W S+ +R+ ++AL G LY+ GG + A L + E Y+P T WT VA MS Sbjct: 412 VTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMST 471 Query: 476 EPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGE 535 Y T+ G +Y GG + + ++P + W A M + R + + Sbjct: 472 RRRYVRVATLDGN-LYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEG 530 Query: 536 RLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGY 595 LYV GGN GTS + V E YSP W +A M +S + + +Y VGG Sbjct: 531 ALYVAGGND--GTSCLNSV---ERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGN 585 Query: 596 SWNNRCMVEIVQKYDPDKDEW---HKVFDLPESLGGIRACTLTVFPPEETTPSPSRES 650 ++ + ++KY+P ++W +F S+G L PP T S S S Sbjct: 586 DGSS--SLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLELLNFPPPSSPTLSVSSTS 641 >gi|11056006 kelch-like 12 [Homo sapiens] Length = 568 Score = 248 bits (632), Expect = 2e-65 Identities = 156/567 (27%), Positives = 271/567 (47%), Gaps = 16/567 (2%) Query: 71 SNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQ 130 +NTH+ +L + LR LCDVTL D FP HR+++A+ SDYF AMFT + E+ Sbjct: 12 TNTHAKSILNSMNSLRKSNTLCDVTLRVEQKD--FPAHRIVLAACSDYFCAMFTSELSEK 69 Query: 131 DLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISG 190 + + G++ + ++DF+YT + + ++N+Q+ L AA LQ+ V C FL S Sbjct: 70 GKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQ 129 Query: 191 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLK 250 + NC+ + A T+N ++ + F K+FP ++ EF+ L + ++ + ++ Sbjct: 130 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQ 189 Query: 251 HCTELELFKATCRWLR-LEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCV 309 +E +F+A W++ ++ R + L++ +R PL+TP+ + + + F+R C Sbjct: 190 VDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCR 249 Query: 310 NLLLEASNYQMMPYMQPVMQSDRTAIRSDTTH-LVTLGGVLRQQLVVSKELRMYDEKAHE 368 +L+ EA + + P ++ MQ RT R L+ +GG QQ + + YD K E Sbjct: 250 DLVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPID-VVEKYDPKTQE 308 Query: 369 WKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGK-TAVDTVFRFDPRYNKWMQVASL 427 W L + R + + +YV+GG YD + + ++V+ + W VA + Sbjct: 309 WSFLPSITRKRRYVASVSLHDRIYVIGG---YDGRSRLSSVECLDYTADEDGVWYSVAPM 365 Query: 428 NEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYG 487 N +R + L +Y GG + + ++E Y+P ++W+ + M G V Sbjct: 366 NVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVAS 425 Query: 488 GVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRG 547 GV+Y GG + +DP T W PM T R + + + +YV+GG F G Sbjct: 426 GVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGG--FDG 483 Query: 548 TSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQ 607 T+ V E Y+ D WT + +M + VG V ++Y + GY N+ ++ ++ Sbjct: 484 TAHLSSV---EAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNS--LLSSIE 538 Query: 608 KYDPDKDEWHKVFDLPESLGGIRACTL 634 YDP D W V + C L Sbjct: 539 CYDPIIDSWEVVTSMGTQRCDAGVCVL 565 Score = 93.6 bits (231), Expect = 5e-19 Identities = 53/178 (29%), Positives = 81/178 (45%), Gaps = 5/178 (2%) Query: 359 LRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRY 418 + YD +W L M R G+ V +Y +GG YD G +++V ++DP Sbjct: 396 MERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGG---YD--GLNILNSVEKYDPHT 450 Query: 419 NKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPH 478 W V + KR+ ++ L ++Y VGG + L +VE YN RT+ WT V M+ P Sbjct: 451 GHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPR 510 Query: 479 YGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGER 536 TV G +Y G ++ + C+DP D W M T R +C + E+ Sbjct: 511 CYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVLREK 568 >gi|148664209 kelch-like 10 [Homo sapiens] Length = 608 Score = 242 bits (617), Expect = 9e-64 Identities = 157/567 (27%), Positives = 274/567 (48%), Gaps = 23/567 (4%) Query: 75 SSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMC 134 S++ + F++LRLEG LCDV + + F H+ ++ S S YF+A+FT G + Sbjct: 22 SAMACEIFNELRLEGKLCDVVIKVNGFE--FSAHKNILCSCSSYFRALFTSGWNNTEKKV 79 Query: 135 IKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLD 194 + G+S ++ II++ YT + + DN++ L AA I+ ++ C FL S + LD Sbjct: 80 YNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLD 139 Query: 195 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLS-TGEFLKLPFERLAFVLSSNSLKHCT 253 NC+ + + + Y E+ + F+L NF ++ + EFL+L L ++ + L Sbjct: 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQ 199 Query: 254 ELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLL 312 E +F+A +W+ + + R + L+ +R LM + +N V+ D+++ C ++ Sbjct: 200 EDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVI 259 Query: 313 LEASNYQMMPYMQPVMQSD----RTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHE 368 + A M SD T R L +GG + + YD +A Sbjct: 260 INALKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGS--PTNAIEAYDARADR 317 Query: 369 WKSLA-PMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASL 427 W ++ ++PR HG A + ++Y++GG + D ++V RFDP W QVA + Sbjct: 318 WVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDY-----FNSVKRFDPVKKTWHQVAPM 372 Query: 428 NEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYG 487 + +R + ++ L ++YA+GG + L T E Y P TN+WT +A M E + T Sbjct: 373 HSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLY 432 Query: 488 GVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRG 547 G +YI GG + ++ ++++W APM + R + GE +Y +GG F G Sbjct: 433 GKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGG--FDG 490 Query: 548 TSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQ 607 + + S E YSP+ + W I M +S+ G+ V ++ ++VVGG+ N V+ Sbjct: 491 A---NRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGF--NGFTTTFNVE 545 Query: 608 KYDPDKDEWHKVFDLPESLGGIRACTL 634 YD DEW+ D+ + C + Sbjct: 546 CYDEKTDEWYDAHDMSIYRSALSCCVV 572 >gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] Length = 624 Score = 234 bits (596), Expect = 2e-61 Identities = 155/574 (27%), Positives = 260/574 (45%), Gaps = 18/574 (3%) Query: 60 SSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDA---FPVHRVMMASAS 116 S T +T H+ ++LRL LCDVTL D F H+V++AS+S Sbjct: 45 SQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSS 104 Query: 117 DYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQI 176 FKAMFT G++EQ + + + G+ + ++I+F YTA +S+ + + A QI Sbjct: 105 PVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQI 164 Query: 177 LPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLP 236 V+ C FL+ + N + + A E+ + ++ +F + EF L Sbjct: 165 DSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLS 224 Query: 237 FERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINY 295 +L ++S + L E E+F A W++ + E R + L++ +R +TP L Sbjct: 225 HCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQ 284 Query: 296 VQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVV 355 +Q + +++D+ C + L++ ++ + +P A + + T GG RQ L Sbjct: 285 LQKCEILQSDSRCKDYLVKI--FEELTLHKPTQVMPCRAPKVGRL-IYTAGGYFRQSL-- 339 Query: 356 SKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFD 415 L Y+ W LA + PR V+G LY VGG++N G T + ++ Sbjct: 340 -SYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNN-SPDGNTDSSALDCYN 397 Query: 416 PRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMS 475 P N+W A ++ R + + G++YAVGG + +VE Y P +EW VA M Sbjct: 398 PMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPML 457 Query: 476 EPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGE 535 G V ++Y GG C+ P+ ++W M T+R +C + Sbjct: 458 TRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHN 517 Query: 536 RLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGY 595 +Y G G D + S E Y + WT +A M +S +G+ V + +IYV+GGY Sbjct: 518 CIYAAG-----GYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGY 572 Query: 596 SWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGI 629 + ++ V+ YDPD D W +V + G+ Sbjct: 573 --DGHTFLDSVECYDPDTDTWSEVTRMTSGRSGV 604 Score = 100 bits (248), Expect = 6e-21 Identities = 62/196 (31%), Positives = 94/196 (47%), Gaps = 12/196 (6%) Query: 443 LYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITH---- 498 +Y GG L +E YNP W +A + P G AG V GG++Y GG + Sbjct: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386 Query: 499 DTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCE 558 +T L C++P T++W APM+ R + + +Y +GG+H G ++ V E Sbjct: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSH--GCIHHNSV---E 441 Query: 559 YYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHK 618 Y P D+W +A ML + VGVAV +Y VGG+ NR + + Y P+++EW Sbjct: 442 RYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR--LNSAECYYPERNEWRM 499 Query: 619 VFDLPESLGGIRACTL 634 + + G C L Sbjct: 500 ITAMNTIRSGAGVCVL 515 >gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] Length = 624 Score = 234 bits (596), Expect = 2e-61 Identities = 155/574 (27%), Positives = 260/574 (45%), Gaps = 18/574 (3%) Query: 60 SSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDA---FPVHRVMMASAS 116 S T +T H+ ++LRL LCDVTL D F H+V++AS+S Sbjct: 45 SQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSS 104 Query: 117 DYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQI 176 FKAMFT G++EQ + + + G+ + ++I+F YTA +S+ + + A QI Sbjct: 105 PVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQI 164 Query: 177 LPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLP 236 V+ C FL+ + N + + A E+ + ++ +F + EF L Sbjct: 165 DSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLS 224 Query: 237 FERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINY 295 +L ++S + L E E+F A W++ + E R + L++ +R +TP L Sbjct: 225 HCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQ 284 Query: 296 VQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVV 355 +Q + +++D+ C + L++ ++ + +P A + + T GG RQ L Sbjct: 285 LQKCEILQSDSRCKDYLVKI--FEELTLHKPTQVMPCRAPKVGRL-IYTAGGYFRQSL-- 339 Query: 356 SKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFD 415 L Y+ W LA + PR V+G LY VGG++N G T + ++ Sbjct: 340 -SYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNN-SPDGNTDSSALDCYN 397 Query: 416 PRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMS 475 P N+W A ++ R + + G++YAVGG + +VE Y P +EW VA M Sbjct: 398 PMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPML 457 Query: 476 EPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGE 535 G V ++Y GG C+ P+ ++W M T+R +C + Sbjct: 458 TRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHN 517 Query: 536 RLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGY 595 +Y G G D + S E Y + WT +A M +S +G+ V + +IYV+GGY Sbjct: 518 CIYAAG-----GYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGY 572 Query: 596 SWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGI 629 + ++ V+ YDPD D W +V + G+ Sbjct: 573 --DGHTFLDSVECYDPDTDTWSEVTRMTSGRSGV 604 Score = 100 bits (248), Expect = 6e-21 Identities = 62/196 (31%), Positives = 94/196 (47%), Gaps = 12/196 (6%) Query: 443 LYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITH---- 498 +Y GG L +E YNP W +A + P G AG V GG++Y GG + Sbjct: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386 Query: 499 DTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCE 558 +T L C++P T++W APM+ R + + +Y +GG+H G ++ V E Sbjct: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSH--GCIHHNSV---E 441 Query: 559 YYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHK 618 Y P D+W +A ML + VGVAV +Y VGG+ NR + + Y P+++EW Sbjct: 442 RYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR--LNSAECYYPERNEWRM 499 Query: 619 VFDLPESLGGIRACTL 634 + + G C L Sbjct: 500 ITAMNTIRSGAGVCVL 515 >gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] Length = 505 Score = 221 bits (564), Expect = 1e-57 Identities = 145/500 (29%), Positives = 254/500 (50%), Gaps = 28/500 (5%) Query: 127 MKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVF 186 M E +++ V LR +ID++YTA++ + +N+Q L AA LQ+ V C F Sbjct: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60 Query: 187 LISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSS 246 L S + NC+ + A+ + T++ N++ ++F ++ + EFL L E++ ++SS Sbjct: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120 Query: 247 NSLKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTD 305 + L +E ++F+A W+ + + R +F A+LM+++R PL+ + L+ V+ ++ Sbjct: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180 Query: 306 NTCVNLLLEASNYQMMPYMQPV-MQSDRTAIRSDTT---HLVTLGGVLRQQLVVSKELRM 361 + C + L+EA Y ++P Q + M+S RT +R+ +V +GG Q + + Sbjct: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG---QAPKAIRSVEC 237 Query: 362 YDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 421 YD K W +A + + R + G+ + ++ VGG G V TV +DP ++W Sbjct: 238 YDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGG-----FNGSLRVRTVDSYDPVKDQW 292 Query: 422 MQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGH 481 VA++ ++R+ + L G LYAVGG + + L +VE YN ++NEW +VA M+ Sbjct: 293 TSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSV 352 Query: 482 AGTVYGGVMYISGGITHDTFQ--KELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYV 539 V GG++Y GG + Q + C++ T++W A M+T R + + LY Sbjct: 353 GVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYA 412 Query: 540 IGGNHFRGTSDYDDVL---SCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYS 596 +GG +D L S E Y P + W +A M + + GV +YVVGG Sbjct: 413 VGG--------HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGD- 463 Query: 597 WNNRCMVEIVQKYDPDKDEW 616 + C + V+ Y+P D+W Sbjct: 464 -DGSCNLASVEYYNPTTDKW 482 Score = 74.3 bits (181), Expect = 3e-13 Identities = 53/187 (28%), Positives = 84/187 (44%), Gaps = 7/187 (3%) Query: 443 LYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVY-GGVMYISGGITHDTF 501 L V G A + +VECY+ + W VA++ AG VY G+++ GG Sbjct: 220 LMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRC-RAGMVYMAGLVFAVGGFNGSLR 278 Query: 502 QKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYS 561 + + +DP D+W A M R + LY +GG F G++ V E Y+ Sbjct: 279 VRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGG--FDGSTGLSSV---EAYN 333 Query: 562 PILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFD 621 ++W +A M +S VGV V +Y VGGY +R + V+ Y+ +EW + + Sbjct: 334 IKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAE 393 Query: 622 LPESLGG 628 + G Sbjct: 394 MSTRRSG 400 Score = 38.1 bits (87), Expect = 0.026 Identities = 21/81 (25%), Positives = 36/81 (44%), Gaps = 2/81 (2%) Query: 554 VLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDK 613 + S E Y ++W +A + + G+ ++ VGG+ N V V YDP K Sbjct: 232 IRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGF--NGSLRVRTVDSYDPVK 289 Query: 614 DEWHKVFDLPESLGGIRACTL 634 D+W V ++ + + A L Sbjct: 290 DQWTSVANMRDRRSTLGAAVL 310 >gi|40018614 DRE1 protein [Homo sapiens] Length = 600 Score = 221 bits (564), Expect = 1e-57 Identities = 151/548 (27%), Positives = 262/548 (47%), Gaps = 30/548 (5%) Query: 70 TSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKE 129 + ++H+ +LQ F++ R L DV + + FP HR ++++ S YF+AMF +E Sbjct: 44 SGSSHAENILQIFNEFRDSRLFTDVIICVEGKE--FPCHRAVLSACSSYFRAMFCNDHRE 101 Query: 130 QDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLIS 189 M ++++G+ + + ++YT K+ + +N+Q E +S QI + D C FL Sbjct: 102 SREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEE 161 Query: 190 GVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSL 249 + NC+ + R A+T++L + +F L+ F + EFL+L + L + S+ L Sbjct: 162 QLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDEL 221 Query: 250 KHCTELELFKATCRWL-RLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTC 308 E +F+A RW+ R + R +L+ ++R PL+ P + V+ ++ C Sbjct: 222 VIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPEC 281 Query: 309 VNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTH---LVTLGGVLRQQLVVSKELRMYDEK 365 LL EA Y + + M S RT R T + +V +GG R YD Sbjct: 282 YQLLHEARRYHI---LGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPV 338 Query: 366 AHEWKSLAPM-DAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQV 424 EWKSLA + + + ++ + + N + V GG+ N V+ ++ + N W++V Sbjct: 339 TGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRIN--------SRDVWIYNSQLNIWIRV 390 Query: 425 ASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGT 484 ASLN+ R ++ L G +Y VGG + L +VECY+ +N WT VA + E A T Sbjct: 391 ASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVT 450 Query: 485 VYGGVMYISGGITHD-TFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGN 543 G +++ GG D T ++ +DP+T+ W+ +A + + ++ +YV GG Sbjct: 451 SCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG- 509 Query: 544 HFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV 603 + C Y P+ D W + Q + G++V KIY++GG N Sbjct: 510 -------LTKAIYC--YDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEA-T 559 Query: 604 EIVQKYDP 611 + + YDP Sbjct: 560 DTILCYDP 567 Score = 74.3 bits (181), Expect = 3e-13 Identities = 50/177 (28%), Positives = 83/177 (46%), Gaps = 12/177 (6%) Query: 443 LYAVGGRNAAG--ELPTVECYNPRTNEWTYVAKMSE-PHYGHAGTVYGGVMYISGGITHD 499 + VGG G LP ECY+P T EW +AK+ E +A + +SGG + Sbjct: 315 IVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINS 374 Query: 500 TFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEY 559 +++ ++ + WI+ A + R H M + ++YV+GG + + S E Sbjct: 375 ---RDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGY-----DGQNRLSSVEC 426 Query: 560 YSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW 616 Y ++WT +A + S V K++V+GG +N C + VQ YDP+ + W Sbjct: 427 YDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCS-DKVQSYDPETNSW 482 Score = 53.1 bits (126), Expect = 8e-07 Identities = 33/123 (26%), Positives = 56/123 (45%), Gaps = 11/123 (8%) Query: 356 SKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFD 415 S +++ YD + + W A + + + N +YV GG + ++ +D Sbjct: 469 SDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTK----------AIYCYD 518 Query: 416 PRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELP-TVECYNPRTNEWTYVAKM 474 P + WM V + ++ +S G +Y +GGR GE T+ CY+P T+ T VA M Sbjct: 519 PVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAM 578 Query: 475 SEP 477 P Sbjct: 579 PRP 581 >gi|109150407 kelch-like 6 [Homo sapiens] Length = 621 Score = 218 bits (554), Expect = 2e-56 Identities = 156/561 (27%), Positives = 269/561 (47%), Gaps = 29/561 (5%) Query: 76 SVVLQ-GFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQDLMC 134 S++LQ G + LR+E L DV L + F HRV++A+AS+YF+AMF +KE+ Sbjct: 55 SLILQNGLETLRMENALTDVILCVDIQE--FSCHRVVLAAASNYFRAMFCNDLKEKYEKR 112 Query: 135 IKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVTLD 194 I + GV + ++D+ YT+K + N+Q LEAA+ Q L ++D C FL + + Sbjct: 113 IIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPE 172 Query: 195 NCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTE 254 NCV + R+A+T++L + K V S++++NF +L++ EFL LP + L +L S+ L E Sbjct: 173 NCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEE 232 Query: 255 LELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCVNLLL 313 ++F+ W+R + R+ +++N+R PL+ P + V+ +R LL Sbjct: 233 AQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQ 292 Query: 314 EASNYQMMPYMQPVMQSDRTAIRS---DTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWK 370 EA Y + + S+RT R + + +GG + + V+ E+ D Sbjct: 293 EARMYHL---SGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVA-EVTCLDPLRRSRL 348 Query: 371 SLAPMDAPRYQHGIAVIG----NFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVAS 426 +A + P +H + F V Y + GK V++++ NKW+Q+ Sbjct: 349 EVAKL--PLTEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEY 406 Query: 427 LNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVY 486 LN R + L G +Y +GG + + VE Y+P N W+ A + A T + Sbjct: 407 LNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSH 466 Query: 487 GGVMYISGGITHDTFQKE-LMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHF 545 +Y+ GG + + C+DP T+KW KA M + +R+YV+GG Sbjct: 467 KKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG--- 523 Query: 546 RGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEI 605 + + YSP+ D W + + ++ G+A N++Y+ GG N ++ Sbjct: 524 -------AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNE-VIAT 575 Query: 606 VQKYDPDKDEWHKVFDLPESL 626 V +DP+ + + LP + Sbjct: 576 VLCWDPEAQKLTEECVLPRGV 596 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.321 0.136 0.416 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 25,305,294 Number of Sequences: 37866 Number of extensions: 1120311 Number of successful extensions: 4019 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 141 Number of HSP's successfully gapped in prelim test: 63 Number of HSP's that attempted gapping in prelim test: 2392 Number of HSP's gapped (non-prelim): 446 length of query: 655 length of database: 18,247,518 effective HSP length: 109 effective length of query: 546 effective length of database: 14,120,124 effective search space: 7709587704 effective search space used: 7709587704 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.