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Search of human proteins with 13186251
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13186251 fibroblast growth factor receptor 1 isoform 2
precursor [Homo sapiens]
(820 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 1680 0.0
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 1675 0.0
gi|13186249 fibroblast growth factor receptor 1 isoform 9 precur... 1575 0.0
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 1436 0.0
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 1431 0.0
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 1207 0.0
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 1160 0.0
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 1112 0.0
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 1103 0.0
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 1083 0.0
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 1055 0.0
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 1013 0.0
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 1003 0.0
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 952 0.0
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 883 0.0
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 883 0.0
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 856 0.0
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 782 0.0
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 702 0.0
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 634 0.0
gi|13186241 fibroblast growth factor receptor 1 isoform 6 precur... 405 e-112
gi|13186238 fibroblast growth factor receptor 1 isoform 5 precur... 400 e-111
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 334 2e-91
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 328 2e-89
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 328 2e-89
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 321 2e-87
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge... 269 7e-72
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene... 268 2e-71
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like... 250 4e-66
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap... 244 3e-64
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 1680 bits (4351), Expect = 0.0
Identities = 820/820 (100%), Positives = 820/820 (100%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD 60
MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD 60
Query: 61 VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD 120
VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD
Sbjct: 61 VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD 120
Query: 121 ALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSG 180
ALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSG
Sbjct: 121 ALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSG 180
Query: 181 TPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHT 240
TPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHT
Sbjct: 181 TPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHT 240
Query: 241 YQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP 300
YQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP
Sbjct: 241 YQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP 300
Query: 301 DNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEAL 360
DNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEAL
Sbjct: 301 DNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEAL 360
Query: 361 EERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIP 420
EERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIP
Sbjct: 361 EERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIP 420
Query: 421 LRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGK 480
LRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGK
Sbjct: 421 LRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGK 480
Query: 481 PLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHK 540
PLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHK
Sbjct: 481 PLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHK 540
Query: 541 NIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVS 600
NIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVS
Sbjct: 541 NIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVS 600
Query: 601 CAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL 660
CAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL
Sbjct: 601 CAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL 660
Query: 661 PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKP 720
PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKP
Sbjct: 661 PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKP 720
Query: 721 SNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPD 780
SNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPD
Sbjct: 721 SNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPD 780
Query: 781 TRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 820
TRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
Sbjct: 781 TRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 820
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 1675 bits (4338), Expect = 0.0
Identities = 820/822 (99%), Positives = 820/822 (99%), Gaps = 2/822 (0%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD 60
MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD 60
Query: 61 VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD 120
VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD
Sbjct: 61 VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD 120
Query: 121 ALPSSEDDDDDDDSSSEEKETDNTKPN--PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS 178
ALPSSEDDDDDDDSSSEEKETDNTKPN PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS
Sbjct: 121 ALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS 180
Query: 179 SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN 238
SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN
Sbjct: 181 SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN 240
Query: 239 HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 298
HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI
Sbjct: 241 HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 300
Query: 299 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 358
GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE
Sbjct: 301 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 360
Query: 359 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS 418
ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS
Sbjct: 361 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS 420
Query: 419 IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL 478
IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL
Sbjct: 421 IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL 480
Query: 479 GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 538
GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK
Sbjct: 481 GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 540
Query: 539 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 598
HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL
Sbjct: 541 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 600
Query: 599 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 658
VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG
Sbjct: 601 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 660
Query: 659 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMD 718
RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMD
Sbjct: 661 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMD 720
Query: 719 KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSF 778
KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSF
Sbjct: 721 KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSF 780
Query: 779 PDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 820
PDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
Sbjct: 781 PDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 822
>gi|13186249 fibroblast growth factor receptor 1 isoform 9 precursor
[Homo sapiens]
Length = 785
Score = 1575 bits (4078), Expect = 0.0
Identities = 783/822 (95%), Positives = 783/822 (95%), Gaps = 39/822 (4%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD 60
MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDD 60
Query: 61 VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD 120
VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD
Sbjct: 61 VQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSD 120
Query: 121 ALPSSEDDDDDDDSSSEEKETDNTKPN--PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS 178
ALPSSEDDDDDDDSSSEEKETDNTKPN PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS
Sbjct: 121 ALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPS 180
Query: 179 SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN 238
SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN
Sbjct: 181 SGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSIN 240
Query: 239 HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 298
HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI
Sbjct: 241 HTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKI 300
Query: 299 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 358
GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE
Sbjct: 301 GPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE 360
Query: 359 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS 418
ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS
Sbjct: 361 ALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS 420
Query: 419 IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL 478
IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL
Sbjct: 421 IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL 480
Query: 479 GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 538
GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK
Sbjct: 481 GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 540
Query: 539 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 598
HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL
Sbjct: 541 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 600
Query: 599 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 658
VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG
Sbjct: 601 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 660
Query: 659 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMD 718
RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL
Sbjct: 661 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEEL----------- 709
Query: 719 KPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSF 778
FKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSF
Sbjct: 710 --------------------------FKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSF 743
Query: 779 PDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 820
PDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
Sbjct: 744 PDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 785
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 1436 bits (3717), Expect = 0.0
Identities = 701/701 (100%), Positives = 701/701 (100%)
Query: 120 DALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS 179
DALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS
Sbjct: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS 90
Query: 180 GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINH 239
GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINH
Sbjct: 91 GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINH 150
Query: 240 TYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG 299
TYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG
Sbjct: 151 TYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG 210
Query: 300 PDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEA 359
PDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEA
Sbjct: 211 PDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEA 270
Query: 360 LEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSI 419
LEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSI
Sbjct: 271 LEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSI 330
Query: 420 PLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLG 479
PLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLG
Sbjct: 331 PLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLG 390
Query: 480 KPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKH 539
KPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKH
Sbjct: 391 KPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKH 450
Query: 540 KNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLV 599
KNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLV
Sbjct: 451 KNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLV 510
Query: 600 SCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR 659
SCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR
Sbjct: 511 SCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR 570
Query: 660 LPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDK 719
LPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDK
Sbjct: 571 LPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDK 630
Query: 720 PSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFP 779
PSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFP
Sbjct: 631 PSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFP 690
Query: 780 DTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 820
DTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
Sbjct: 691 DTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 731
Score = 101 bits (252), Expect = 2e-21
Identities = 82/303 (27%), Positives = 118/303 (38%), Gaps = 78/303 (25%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQ------------------------------ 30
MWSWKCLLFWAVLVTATLCTARPSPTLPEQ
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
Query: 31 AQPWGAPVEVESFL--VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAESNR-----TRIT 82
A W +P ++E L V ++ +C ++ WL++G + +R R
Sbjct: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 120
Query: 83 GEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETD 142
+ + VP+D G Y C+ + GS + ++V + P
Sbjct: 121 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPH------------------ 162
Query: 143 NTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLK----NGKEFKPD 198
P+ K V V+F C P P ++WLK NG + PD
Sbjct: 163 ----RPILQAGLPANK------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPD 212
Query: 199 H-------RIGGYKVRYATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSP 250
+ + G ++ + +V D G YTC+ N G +H+ L V+E
Sbjct: 213 NLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALE 272
Query: 251 HRP 253
RP
Sbjct: 273 ERP 275
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 1431 bits (3704), Expect = 0.0
Identities = 701/703 (99%), Positives = 701/703 (99%), Gaps = 2/703 (0%)
Query: 120 DALPSSEDDDDDDDSSSEEKETDNTKPN--PVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 177
DALPSSEDDDDDDDSSSEEKETDNTKPN PVAPYWTSPEKMEKKLHAVPAAKTVKFKCP
Sbjct: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 90
Query: 178 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 237
SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI
Sbjct: 91 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 150
Query: 238 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 297
NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK
Sbjct: 151 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 210
Query: 298 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 357
IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL
Sbjct: 211 IGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVL 270
Query: 358 EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK 417
EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK
Sbjct: 271 EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAK 330
Query: 418 SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 477
SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV
Sbjct: 331 SIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLV 390
Query: 478 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 537
LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG
Sbjct: 391 LGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIG 450
Query: 538 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 597
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD
Sbjct: 451 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKD 510
Query: 598 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 657
LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN
Sbjct: 511 LVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTN 570
Query: 658 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRM 717
GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRM
Sbjct: 571 GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRM 630
Query: 718 DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS 777
DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS
Sbjct: 631 DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPS 690
Query: 778 FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 820
FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
Sbjct: 691 FPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR 733
Score = 100 bits (250), Expect = 4e-21
Identities = 82/305 (26%), Positives = 118/305 (38%), Gaps = 80/305 (26%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQ------------------------------ 30
MWSWKCLLFWAVLVTATLCTARPSPTLPEQ
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
Query: 31 --AQPWGAPVEVESFL--VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAESNR-----TR 80
A W +P ++E L V ++ +C ++ WL++G + +R R
Sbjct: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 120
Query: 81 ITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKE 140
+ + VP+D G Y C+ + GS + ++V + P
Sbjct: 121 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPH---------------- 164
Query: 141 TDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLK----NGKEFK 196
P+ K V V+F C P P ++WLK NG +
Sbjct: 165 ------RPILQAGLPANK------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG 212
Query: 197 PDH-------RIGGYKVRYATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVVER 248
PD+ + G ++ + +V D G YTC+ N G +H+ L V+E
Sbjct: 213 PDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEA 272
Query: 249 SPHRP 253
RP
Sbjct: 273 LEERP 277
>gi|221316639 fibroblast growth factor receptor 2 isoform 1
precursor [Homo sapiens]
Length = 821
Score = 1207 bits (3122), Expect = 0.0
Identities = 594/827 (71%), Positives = 685/827 (82%), Gaps = 16/827 (1%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 53
M SW + V+ ATL ARPS +L E +P P + E ++ PG+ L++
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 54 RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 113
RC L+D I+W +DGV L +NRT + GE ++++ + P DSGLYAC S S+T Y
Sbjct: 61 RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY 119
Query: 114 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVK 173
F VNV+DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA TVK
Sbjct: 120 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR---APYWTNTEKMEKRLHAVPAANTVK 176
Query: 174 FKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENE 233
F+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VENE
Sbjct: 177 FRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 234 YGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEV 293
YGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+E
Sbjct: 237 YGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEK 296
Query: 294 NGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAW 353
NGSK GPD LPY+++LK AGVNTTDKE+EVL++RNV+FEDAGEYTCLAGNSIG+S HSAW
Sbjct: 297 NGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAW 356
Query: 354 LTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVH 413
LTVL A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF SQ AVH
Sbjct: 357 LTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVH 416
Query: 414 KLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPRWEL 471
KL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPEDP+WE
Sbjct: 417 KLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEF 476
Query: 472 PRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEME 531
PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL+SEME
Sbjct: 477 PRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEME 536
Query: 532 MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEE 591
MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ + PEE
Sbjct: 537 MMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEE 596
Query: 592 QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDY 651
Q++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++IDY
Sbjct: 597 QMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDY 656
Query: 652 YKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLL 711
YKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEELFKLL
Sbjct: 657 YKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL 716
Query: 712 KEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPL 771
KEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+EYLDLS PL
Sbjct: 717 KEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPL 776
Query: 772 DQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLK 818
+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP++P NG +K
Sbjct: 777 EQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--INGSVK 820
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 1160 bits (3001), Expect = 0.0
Identities = 578/830 (69%), Positives = 673/830 (81%), Gaps = 21/830 (2%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 53
M SW + V+ ATL ARPS +L E +P P + E ++ PG+ L++
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 54 RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 113
RC L+D I+W +DGV L +NRT + GE ++++ + P DSGLYAC S S+T Y
Sbjct: 61 RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY 119
Query: 114 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVK 173
F VNV+DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA TVK
Sbjct: 120 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR---APYWTNTEKMEKRLHAVPAANTVK 176
Query: 174 FKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENE 233
F+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VENE
Sbjct: 177 FRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 234 YGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEV 293
YGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+E
Sbjct: 237 YGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEK 296
Query: 294 NGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAW 353
NGSK GPD LPY+++LK +G+N+++ E VL L NV+ DAGEY C N IG ++ SAW
Sbjct: 297 NGSKYGPDGLPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYICKVSNYIGQANQSAW 354
Query: 354 LTVL---EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQM 410
LTVL +A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF SQ
Sbjct: 355 LTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQP 414
Query: 411 AVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPR 468
AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPEDP+
Sbjct: 415 AVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPK 474
Query: 469 WELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLIS 528
WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL+S
Sbjct: 475 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVS 534
Query: 529 EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHN 588
EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ +
Sbjct: 535 EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRV 594
Query: 589 PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHH 648
PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++
Sbjct: 595 PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINN 654
Query: 649 IDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF 708
IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEELF
Sbjct: 655 IDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF 714
Query: 709 KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLS 768
KLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+EYLDLS
Sbjct: 715 KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLS 774
Query: 769 MPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLK 818
PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP++P NG +K
Sbjct: 775 QPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--INGSVK 821
>gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
Length = 706
Score = 1112 bits (2875), Expect = 0.0
Identities = 536/679 (78%), Positives = 601/679 (88%), Gaps = 5/679 (0%)
Query: 142 DNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRI 201
D T APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRI
Sbjct: 30 DTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRI 89
Query: 202 GGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPA 261
GGYKVR WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPA
Sbjct: 90 GGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPA 149
Query: 262 NKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEM 321
N + +G +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+
Sbjct: 150 NASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEI 209
Query: 322 EVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTG 381
EVL++RNV+FEDAGEYTCLAGNSIG+S HSAWLTVL A + SP YLEI IYC G
Sbjct: 210 EVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIG 269
Query: 382 AFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLL 441
FLI+CMV +VI+ +MK+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS L
Sbjct: 270 VFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPL 329
Query: 442 VR-PSRLSSSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLD 499
VR +RLSS+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+D
Sbjct: 330 VRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGID 389
Query: 500 KDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 559
KDKP VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIV
Sbjct: 390 KDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 449
Query: 560 EYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIH 619
EYASKGNLREYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIH
Sbjct: 450 EYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIH 509
Query: 620 RDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQS 679
RDLAARNVLVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQS
Sbjct: 510 RDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 569
Query: 680 DVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVP 739
DVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVP
Sbjct: 570 DVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVP 629
Query: 740 SQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPL 799
SQRPTFKQLVEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+
Sbjct: 630 SQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPM 688
Query: 800 PEEPCLPRHPAQLANGGLK 818
P EPCLP++P NG +K
Sbjct: 689 PYEPCLPQYPH--INGSVK 705
Score = 51.6 bits (122), Expect = 3e-06
Identities = 62/275 (22%), Positives = 104/275 (37%), Gaps = 59/275 (21%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAP-------VEVESFLVHPGDLL 51
M SW + V+ ATL ARPS +L E +P GAP +E V + +
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
Query: 52 QLRCRLRDD-VQSINWLRDGVQLAESNRTRITGEEVE-------VQDSVPADSGLYACVT 103
+ RC + + ++ WL++G + + +R I G +V ++ VP+D G Y CV
Sbjct: 61 KFRCPAGGNPMPTMRWLKNGKEFKQEHR--IGGYKVRNQHWSLIMESVVPSDKGNYTCVV 118
Query: 104 SSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKL 163
+ GS + ++V + P P+
Sbjct: 119 ENEYGSINHTYHLDVVERSPH----------------------RPILQAGLPANA----- 151
Query: 164 HAVPAAKTVKFKCPSSGTPNPTLRWL----KNGKEFKPDH-------RIGGYKVRYATWS 212
+ V+F C P ++W+ KNG ++ PD + G
Sbjct: 152 -STVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIE 210
Query: 213 II-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVV 246
++ + +V D G YTC+ N G H+ L V+
Sbjct: 211 VLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 245
>gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
Length = 704
Score = 1103 bits (2853), Expect = 0.0
Identities = 534/679 (78%), Positives = 599/679 (88%), Gaps = 7/679 (1%)
Query: 142 DNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRI 201
D T APYWT+ EKMEK+LHAVPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRI
Sbjct: 30 DTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRI 89
Query: 202 GGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPA 261
GGYKVR WS+IM+SVVPSDKGNYTC+VENEYGSINHTY LDVVERSPHRPILQAGLPA
Sbjct: 90 GGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPA 149
Query: 262 NKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEM 321
N + +G +VEF+CKVYSD QPHIQW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+
Sbjct: 150 NASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEI 209
Query: 322 EVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTG 381
EVL++RNV+FEDAGEYTCLAGNSIG+S HSAWLTVL A + SP YLEI IYC G
Sbjct: 210 EVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIG 269
Query: 382 AFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLL 441
FLI+CMV +VI+ +MK+ TKK DF SQ AVHKL K IPLRRQV SA+SS+SMNS L
Sbjct: 270 VFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQV--SAESSSSMNSNTPL 327
Query: 442 VR-PSRLSSSG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLD 499
VR +RLSS+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+D
Sbjct: 328 VRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGID 387
Query: 500 KDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 559
KDKP VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIV
Sbjct: 388 KDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 447
Query: 560 EYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIH 619
EYASKGNLREYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIH
Sbjct: 448 EYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIH 507
Query: 620 RDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQS 679
RDLAARNVLVTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQS
Sbjct: 508 RDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 567
Query: 680 DVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVP 739
DVWSFGVL+WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVP
Sbjct: 568 DVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVP 627
Query: 740 SQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPL 799
SQRPTFKQLVEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+
Sbjct: 628 SQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPM 686
Query: 800 PEEPCLPRHPAQLANGGLK 818
P EPCLP++P NG +K
Sbjct: 687 PYEPCLPQYPH--INGSVK 703
Score = 51.6 bits (122), Expect = 3e-06
Identities = 62/275 (22%), Positives = 104/275 (37%), Gaps = 59/275 (21%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAP-------VEVESFLVHPGDLL 51
M SW + V+ ATL ARPS +L E +P GAP +E V + +
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTV 60
Query: 52 QLRCRLRDD-VQSINWLRDGVQLAESNRTRITGEEVE-------VQDSVPADSGLYACVT 103
+ RC + + ++ WL++G + + +R I G +V ++ VP+D G Y CV
Sbjct: 61 KFRCPAGGNPMPTMRWLKNGKEFKQEHR--IGGYKVRNQHWSLIMESVVPSDKGNYTCVV 118
Query: 104 SSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKL 163
+ GS + ++V + P P+
Sbjct: 119 ENEYGSINHTYHLDVVERSPH----------------------RPILQAGLPANA----- 151
Query: 164 HAVPAAKTVKFKCPSSGTPNPTLRWL----KNGKEFKPDH-------RIGGYKVRYATWS 212
+ V+F C P ++W+ KNG ++ PD + G
Sbjct: 152 -STVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIE 210
Query: 213 II-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVV 246
++ + +V D G YTC+ N G H+ L V+
Sbjct: 211 VLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL 245
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 1083 bits (2802), Expect = 0.0
Identities = 539/774 (69%), Positives = 626/774 (80%), Gaps = 18/774 (2%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 53
M SW + V+ ATL ARPS +L E +P P + E ++ PG+ L++
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 54 RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 113
RC L+D I+W +DGV L +NRT + GE ++++ + P DSGLYAC S S+T Y
Sbjct: 61 RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY 119
Query: 114 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVK 173
F VNV+DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA TVK
Sbjct: 120 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR---APYWTNTEKMEKRLHAVPAANTVK 176
Query: 174 FKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENE 233
F+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VENE
Sbjct: 177 FRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 234 YGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEV 293
YGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+E
Sbjct: 237 YGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEK 296
Query: 294 NGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAW 353
NGSK GPD LPY+++LK +G+N+++ E VL L NV+ DAGEY C N IG ++ SAW
Sbjct: 297 NGSKYGPDGLPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYICKVSNYIGQANQSAW 354
Query: 354 LTVL---EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQM 410
LTVL +A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK DF SQ
Sbjct: 355 LTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQP 414
Query: 411 AVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYELPEDPR 468
AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYELPEDP+
Sbjct: 415 AVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPK 474
Query: 469 WELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLIS 528
WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDLSDL+S
Sbjct: 475 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVS 534
Query: 529 EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHN 588
EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y+ +
Sbjct: 535 EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRV 594
Query: 589 PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHH 648
PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLARDI++
Sbjct: 595 PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINN 654
Query: 649 IDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF 708
IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+PVEELF
Sbjct: 655 IDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF 714
Query: 709 KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 762
KLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+
Sbjct: 715 KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 768
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 1055 bits (2727), Expect = 0.0
Identities = 512/673 (76%), Positives = 578/673 (85%), Gaps = 5/673 (0%)
Query: 106 PSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHA 165
PS S ++ DA+ S +D+DD D + E N K APYWT+ EKMEK+LHA
Sbjct: 23 PSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKR---APYWTNTEKMEKRLHA 79
Query: 166 VPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGN 225
VPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGN
Sbjct: 80 VPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGN 139
Query: 226 YTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHI 285
YTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHI
Sbjct: 140 YTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHI 199
Query: 286 QWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSI 345
QW+KH+E NGSK GPD LPY+++LK AGVNTTDKE+EVL++RNV+FEDAGEYTCLAGNSI
Sbjct: 200 QWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSI 259
Query: 346 GLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSD 405
G+S HSAWLTVL A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TKK D
Sbjct: 260 GISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPD 319
Query: 406 FHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSEYEL 463
F SQ AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSEYEL
Sbjct: 320 FSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYEL 379
Query: 464 PEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL 523
PEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATEKDL
Sbjct: 380 PEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL 439
Query: 524 SDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCY 583
SDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+EY Y
Sbjct: 440 SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSY 499
Query: 584 NPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLA 643
+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADFGLA
Sbjct: 500 DINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLA 559
Query: 644 RDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVP 703
RDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYPG+P
Sbjct: 560 RDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP 619
Query: 704 VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQE 763
VEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+N+E
Sbjct: 620 VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEE 679
Query: 764 YLDLSMPLDQYSP 776
+S +D + P
Sbjct: 680 EKKVSGAVDCHKP 692
Score = 37.7 bits (86), Expect = 0.044
Identities = 61/301 (20%), Positives = 104/301 (34%), Gaps = 85/301 (28%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPE------------------------------- 29
M SW + V+ ATL ARPS +L E
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
Query: 30 --QAQPWGAPVEVESFL--VHPGDLLQLRCRLRDD-VQSINWLRDGVQLAESNRTRITGE 84
+A W ++E L V + ++ RC + + ++ WL++G + + +R I G
Sbjct: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR--IGGY 118
Query: 85 EVE-------VQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSE 137
+V ++ VP+D G Y CV + GS + ++V + P
Sbjct: 119 KVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPH------------- 165
Query: 138 EKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWL----KNGK 193
P+ + V+F C P ++W+ KNG
Sbjct: 166 ---------RPILQAGLPANA------STVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGS 210
Query: 194 EFKPDH-------RIGGYKVRYATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDV 245
++ PD + G ++ + +V D G YTC+ N G H+ L V
Sbjct: 211 KYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTV 270
Query: 246 V 246
+
Sbjct: 271 L 271
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 1013 bits (2619), Expect = 0.0
Identities = 508/774 (65%), Positives = 608/774 (78%), Gaps = 17/774 (2%)
Query: 33 PWGAPVEVESFLVHPGDLLQLRCRLRDD--VQSINWLRDGVQLAESNRTRITGEEVEVQD 90
P P + E + GD ++L C + W++DG L S R + + ++V +
Sbjct: 39 PGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLN 98
Query: 91 SVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVA 150
+ DSG Y+C + +FSV V+DA PSS DD+D +D E ++T + A
Sbjct: 99 ASHEDSGAYSC-RQRLTQRVLCHFSVRVTDA-PSSGDDEDGED------EAEDTGVDTGA 150
Query: 151 PYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYAT 210
PYWT PE+M+KKL AVPAA TV+F+CP++G P P++ WLKNG+EF+ +HRIGG K+R+
Sbjct: 151 PYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQ 210
Query: 211 WSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSN 270
WS++M+SVVPSD+GNYTC+VEN++GSI TY LDV+ERSPHRPILQAGLPAN+T LGS+
Sbjct: 211 WSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSD 270
Query: 271 VEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVS 330
VEF CKVYSD QPHIQWLKH+EVNGSK+GPD PYV +LKTAG NTTDKE+EVL L NV+
Sbjct: 271 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVT 330
Query: 331 FEDAGEYTCLAGNSIGLSHHSAWLTVLEALEER-PAVMTSPLYLEIIIYCTGAFLISCMV 389
FEDAGEYTCLAGNSIG SHHSAWL VL A EE A +Y I+ Y G FL +V
Sbjct: 331 FEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVV 390
Query: 390 GSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSS 449
+V + +++S KK VHK+++ PL+RQV S +S+ASM+S LVR +RLSS
Sbjct: 391 AAVTLCRLRSPPKKG--LGSPTVHKISR-FPLKRQV--SLESNASMSSNTPLVRIARLSS 445
Query: 450 SGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKV 509
P LA VSE ELP DP+WEL R RL LGKPLGEGCFGQVV+AEAIG+DKD+ + V
Sbjct: 446 GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTV 505
Query: 510 AVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLRE 569
AVKMLK DAT+KDLSDL+SEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE
Sbjct: 506 AVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLRE 565
Query: 570 YLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV 629
+L+ARRPPGL+Y ++ PEEQL+ KDLVSCAYQVARGMEYLAS+KCIHRDLAARNVLV
Sbjct: 566 FLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLV 625
Query: 630 TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLW 689
TEDNVMKIADFGLARD+H++DYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVLLW
Sbjct: 626 TEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLW 685
Query: 690 EIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLV 749
EIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCT++LYM+MR+CWHA PSQRPTFKQLV
Sbjct: 686 EIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLV 745
Query: 750 EDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEP 803
EDLDR++ +TS EYLDLS P +QYSP DT SS+ SSG+DSVF+H+ LP P
Sbjct: 746 EDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSS-SSGDDSVFAHDLLPPAP 798
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 1003 bits (2592), Expect = 0.0
Identities = 492/662 (74%), Positives = 559/662 (84%), Gaps = 10/662 (1%)
Query: 106 PSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHA 165
PS S ++ DA+ S +D+DD D + E N K APYWT+ EKMEK+LHA
Sbjct: 23 PSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSNNKR---APYWTNTEKMEKRLHA 79
Query: 166 VPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGN 225
VPAA TVKF+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGN
Sbjct: 80 VPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGN 139
Query: 226 YTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHI 285
YTC+VENEYGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHI
Sbjct: 140 YTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHI 199
Query: 286 QWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSI 345
QW+KH+E NGSK GPD LPY+++LK +G+N+++ E VL L NV+ DAGEY C N I
Sbjct: 200 QWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYICKVSNYI 257
Query: 346 GLSHHSAWLTVL---EALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTK 402
G ++ SAWLTVL +A + SP YLEI IYC G FLI+CMV +VI+ +MK+ TK
Sbjct: 258 GQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTK 317
Query: 403 KSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPMLAGVSE 460
K DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPMLAGVSE
Sbjct: 318 KPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSE 377
Query: 461 YELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATE 520
YELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK DATE
Sbjct: 378 YELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATE 437
Query: 521 KDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLE 580
KDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARRPPG+E
Sbjct: 438 KDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGME 497
Query: 581 YCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF 640
Y Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVMKIADF
Sbjct: 498 YSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADF 557
Query: 641 GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYP 700
GLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLGGSPYP
Sbjct: 558 GLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYP 617
Query: 701 GVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTS 760
G+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI+ LT+
Sbjct: 618 GIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 677
Query: 761 NQ 762
N+
Sbjct: 678 NE 679
Score = 38.1 bits (87), Expect = 0.033
Identities = 62/302 (20%), Positives = 105/302 (34%), Gaps = 85/302 (28%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPE------------------------------- 29
M SW + V+ ATL ARPS +L E
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEDAISSGDDEDDTDGAEDFVSENSN 60
Query: 30 --QAQPWGAPVEVESFL--VHPGDLLQLRCRLRDD-VQSINWLRDGVQLAESNRTRITGE 84
+A W ++E L V + ++ RC + + ++ WL++G + + +R I G
Sbjct: 61 NKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR--IGGY 118
Query: 85 EVE-------VQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSE 137
+V ++ VP+D G Y CV + GS + ++V + P
Sbjct: 119 KVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPH------------- 165
Query: 138 EKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWL----KNGK 193
P+ + V+F C P ++W+ KNG
Sbjct: 166 ---------RPILQAGLPANA------STVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGS 210
Query: 194 EFKPDH-------RIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVV 246
++ PD + G A + + +V +D G Y C V N G N + L V+
Sbjct: 211 KYGPDGLPYLKVLKHSGINSSNAE-VLALFNVTEADAGEYICKVSNYIGQANQSAWLTVL 269
Query: 247 ER 248
+
Sbjct: 270 PK 271
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 952 bits (2462), Expect = 0.0
Identities = 485/777 (62%), Positives = 592/777 (76%), Gaps = 21/777 (2%)
Query: 33 PWGAPVEVESFLVHPGDLLQLRCRLRDD--VQSINWLRDGVQLAESNRTRITGEEVEVQD 90
P P + E + GD ++L C + W++DG L S R + + ++V +
Sbjct: 39 PGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLN 98
Query: 91 SVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVA 150
+ DSG Y+C + +FSV V+DA PSS DD+D +D E ++T + A
Sbjct: 99 ASHEDSGAYSC-RQRLTQRVLCHFSVRVTDA-PSSGDDEDGED------EAEDTGVDTGA 150
Query: 151 PYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYAT 210
PYWT PE+M+KKL AVPAA TV+F+CP++G P P++ WLKNG+EF+ +HRIGG K+R+
Sbjct: 151 PYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQ 210
Query: 211 WSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSN 270
WS++M+SVVPSD+GNYTC+VEN++GSI TY LDV+ERSPHRPILQAGLPAN+T LGS+
Sbjct: 211 WSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSD 270
Query: 271 VEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVS 330
VEF CKVYSD QPHIQWLKH+EVNGSK+GPD PYV +LK+ + + ++ L L NVS
Sbjct: 271 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVR-LRLANVS 329
Query: 331 FEDAGEYTCLAGNSIGLSHHSAWLTVL--EALEER--PAVMTSPLYLEIIIYCTGAFLIS 386
D GEY C A N IG++ + WL+V A EE A +Y I+ Y G FL
Sbjct: 330 ERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLFI 389
Query: 387 CMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSR 446
+V +V + +++S KK VHK+++ PL+RQV S +S+ASM+S LVR +R
Sbjct: 390 LVVAAVTLCRLRSPPKKG--LGSPTVHKISR-FPLKRQV--SLESNASMSSNTPLVRIAR 444
Query: 447 LSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV 506
LSS P LA VSE ELP DP+WEL R RL LGKPLGEGCFGQVV+AEAIG+DKD+ +
Sbjct: 445 LSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKP 504
Query: 507 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 566
VAVKMLK DAT+KDLSDL+SEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGN
Sbjct: 505 VTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGN 564
Query: 567 LREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARN 626
LRE+L+ARRPPGL+Y ++ PEEQL+ KDLVSCAYQVARGMEYLAS+KCIHRDLAARN
Sbjct: 565 LREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARN 624
Query: 627 VLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGV 686
VLVTEDNVMKIADFGLARD+H++DYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGV
Sbjct: 625 VLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 684
Query: 687 LLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFK 746
LLWEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCT++LYM+MR+CWHA PSQRPTFK
Sbjct: 685 LLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFK 744
Query: 747 QLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEP 803
QLVEDLDR++ +TS EYLDLS P +QYSP DT SS+ SSG+DSVF+H+ LP P
Sbjct: 745 QLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSS-SSGDDSVFAHDLLPPAP 800
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 883 bits (2281), Expect = 0.0
Identities = 451/741 (60%), Positives = 559/741 (75%), Gaps = 22/741 (2%)
Query: 65 NWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPS 124
+W ++G +LA + R R +E+ +P D+G Y C+ S ++ D+L S
Sbjct: 65 HWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARG-SMIVLQNLTLITGDSLTS 123
Query: 125 SEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNP 184
S +DD+D S + ++ P APYWT P++MEKKLHAVPA TVKF+CP++G P P
Sbjct: 124 S--NDDEDPKSHRDPSNRHSYPQQ-APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP 180
Query: 185 TLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLD 244
T+RWLK+G+ F ++RIGG ++R+ WS++M+SVVPSD+G YTC+VEN GSI + Y LD
Sbjct: 181 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD 240
Query: 245 VVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLP 304
V+ERSPHRPILQAGLPAN T +GS+VE +CKVYSD QPHIQWLKHI +NGS G D P
Sbjct: 241 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP 300
Query: 305 YVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP 364
YVQ+LKTA +N++ E+EVL+LRNVS EDAGEYTCLAGNSIGLS+ SAWLTVL EE P
Sbjct: 301 YVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP--EEDP 356
Query: 365 ---AVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQ--MAVHKLAKSI 419
A Y +II+Y +G+ ++ ++ +Y+ G H + V KL++
Sbjct: 357 TWTAAAPEARYTDIILYASGSLALAVLLLLAGLYR---GQALHGRHPRPPATVQKLSR-F 412
Query: 420 PLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLG 479
PL RQ ++ + SS +S LVR RLSSSG +LAG+ +LP DP WE PRDRLVLG
Sbjct: 413 PLARQFSLESGSSGKSSSS--LVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLG 470
Query: 480 KPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKH 539
KPLGEGCFGQVV AEA G+D +P++ + VAVKMLK +A++KDL+DL+SEME+MK+IG+H
Sbjct: 471 KPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRH 530
Query: 540 KNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLV 599
KNIINLLG CTQ+GPLYVIVE A+KGNLRE+L+ARRPPG + + + E LS LV
Sbjct: 531 KNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLV 590
Query: 600 SCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR 659
SCAYQVARGM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR +HHIDYYKKT+NGR
Sbjct: 591 SCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGR 650
Query: 660 LPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDK 719
LPVKWMAPEALFDR+YTHQSDVWSFG+LLWEIFTLGGSPYPG+PVEELF LL+EGHRMD+
Sbjct: 651 LPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDR 710
Query: 720 PSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFP 779
P +C ELY +MR+CWHA PSQRPTFKQLVE LD+++ L ++EYLDL + YSPS
Sbjct: 711 PPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGG 769
Query: 780 DTRSSTCSSGEDSVFSHEPLP 800
D SSTCSS DSVFSH+PLP
Sbjct: 770 DA-SSTCSS-SDSVFSHDPLP 788
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 883 bits (2281), Expect = 0.0
Identities = 451/741 (60%), Positives = 559/741 (75%), Gaps = 22/741 (2%)
Query: 65 NWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPS 124
+W ++G +LA + R R +E+ +P D+G Y C+ S ++ D+L S
Sbjct: 65 HWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARG-SMIVLQNLTLITGDSLTS 123
Query: 125 SEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNP 184
S +DD+D S + ++ P APYWT P++MEKKLHAVPA TVKF+CP++G P P
Sbjct: 124 S--NDDEDPKSHRDPSNRHSYPQQ-APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP 180
Query: 185 TLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLD 244
T+RWLK+G+ F ++RIGG ++R+ WS++M+SVVPSD+G YTC+VEN GSI + Y LD
Sbjct: 181 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD 240
Query: 245 VVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLP 304
V+ERSPHRPILQAGLPAN T +GS+VE +CKVYSD QPHIQWLKHI +NGS G D P
Sbjct: 241 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP 300
Query: 305 YVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP 364
YVQ+LKTA +N++ E+EVL+LRNVS EDAGEYTCLAGNSIGLS+ SAWLTVL EE P
Sbjct: 301 YVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP--EEDP 356
Query: 365 ---AVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQ--MAVHKLAKSI 419
A Y +II+Y +G+ ++ ++ +Y+ G H + V KL++
Sbjct: 357 TWTAAAPEARYTDIILYASGSLALAVLLLLAGLYR---GQALHGRHPRPPATVQKLSR-F 412
Query: 420 PLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLG 479
PL RQ ++ + SS +S LVR RLSSSG +LAG+ +LP DP WE PRDRLVLG
Sbjct: 413 PLARQFSLESGSSGKSSSS--LVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLG 470
Query: 480 KPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKH 539
KPLGEGCFGQVV AEA G+D +P++ + VAVKMLK +A++KDL+DL+SEME+MK+IG+H
Sbjct: 471 KPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRH 530
Query: 540 KNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLV 599
KNIINLLG CTQ+GPLYVIVE A+KGNLRE+L+ARRPPG + + + E LS LV
Sbjct: 531 KNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLV 590
Query: 600 SCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR 659
SCAYQVARGM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR +HHIDYYKKT+NGR
Sbjct: 591 SCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGR 650
Query: 660 LPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDK 719
LPVKWMAPEALFDR+YTHQSDVWSFG+LLWEIFTLGGSPYPG+PVEELF LL+EGHRMD+
Sbjct: 651 LPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDR 710
Query: 720 PSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFP 779
P +C ELY +MR+CWHA PSQRPTFKQLVE LD+++ L ++EYLDL + YSPS
Sbjct: 711 PPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGG 769
Query: 780 DTRSSTCSSGEDSVFSHEPLP 800
D SSTCSS DSVFSH+PLP
Sbjct: 770 DA-SSTCSS-SDSVFSHDPLP 788
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 856 bits (2212), Expect = 0.0
Identities = 438/736 (59%), Positives = 534/736 (72%), Gaps = 52/736 (7%)
Query: 65 NWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPS 124
+W ++G +LA + R R +E+ +P D+G Y C+ S ++ D+L S
Sbjct: 65 HWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARG-SMIVLQNLTLITGDSLTS 123
Query: 125 SEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNP 184
S +DD+D S + ++ P APYWT P++MEKKLHAVPA TVKF+CP++G P P
Sbjct: 124 S--NDDEDPKSHRDPSNRHSYPQQ-APYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTP 180
Query: 185 TLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLD 244
T+RWLK+G+ F ++RIGG ++R+ WS++M+SVVPSD+G YTC+VEN GSI + Y LD
Sbjct: 181 TIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLD 240
Query: 245 VVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLP 304
V+ERSPHRPILQAGLPAN T +GS+VE +CKVYSD QPHIQWLKHI +NGS G D P
Sbjct: 241 VLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFP 300
Query: 305 YVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP 364
YVQ+LKTA +N++ E+EVL+LRNVS EDAGEYTCLAGNSIGLS+ SAWLTVL P
Sbjct: 301 YVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGRIP 358
Query: 365 AVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQ 424
+ L +G KS
Sbjct: 359 HLTCDSL-------------------------TPAGRTKSP------------------T 375
Query: 425 VTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGE 484
+ S +S +S S LVR RLSSSG +LAG+ +LP DP WE PRDRLVLGKPLGE
Sbjct: 376 LQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGE 435
Query: 485 GCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIIN 544
GCFGQVV AEA G+D +P++ + VAVKMLK +A++KDL+DL+SEME+MK+IG+HKNIIN
Sbjct: 436 GCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIIN 495
Query: 545 LLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQ 604
LLG CTQ+GPLYVIVE A+KGNLRE+L+ARRPPG + + + E LS LVSCAYQ
Sbjct: 496 LLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQ 555
Query: 605 VARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKW 664
VARGM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR +HHIDYYKKT+NGRLPVKW
Sbjct: 556 VARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKW 615
Query: 665 MAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT 724
MAPEALFDR+YTHQSDVWSFG+LLWEIFTLGGSPYPG+PVEELF LL+EGHRMD+P +C
Sbjct: 616 MAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCP 675
Query: 725 NELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSS 784
ELY +MR+CWHA PSQRPTFKQLVE LD+++ L ++EYLDL + YSPS D SS
Sbjct: 676 PELYGLMRECWHAAPSQRPTFKQLVEALDKVL-LAVSEEYLDLRLTFGPYSPSGGDA-SS 733
Query: 785 TCSSGEDSVFSHEPLP 800
TCSS DSVFSH+PLP
Sbjct: 734 TCSS-SDSVFSHDPLP 748
Score = 53.1 bits (126), Expect = 1e-06
Identities = 56/234 (23%), Positives = 89/234 (38%), Gaps = 45/234 (19%)
Query: 155 SPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSII 214
S E+ E++L V + V+ C G W K G P R+ G++ R +
Sbjct: 37 SLEQQEQEL-TVALGQPVRLCC---GRAERGGHWYKEGSRLAPAGRVRGWRGR-----LE 87
Query: 215 MDSVVPSDKGNYTCIVENEYGSINH---------TYQLDVVERSPHR-PILQAGLPANK- 263
+ S +P D G Y C+ + + T D + HR P + P
Sbjct: 88 IASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAP 147
Query: 264 -------------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILK 310
V G+ V+F C +P P I+WLK +G +N +
Sbjct: 148 YWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLK----DGQAFHGEN-------R 196
Query: 311 TAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP 364
G+ + ++ + +V D G YTCL N++G ++ L VLE RP
Sbjct: 197 IGGIRLRHQHWSLV-MESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRP 249
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 782 bits (2019), Expect = 0.0
Identities = 409/663 (61%), Positives = 484/663 (73%), Gaps = 54/663 (8%)
Query: 186 LRWLKNGKEFKPDHR---IGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQ 242
+ W K+G P++R IG Y + + P D G Y C S +
Sbjct: 70 ISWTKDGVHLGPNNRTVLIGEY--------LQIKGATPRDSGLYACTASRTVDSETWYFM 121
Query: 243 LDVVE-------------------------RSPHRPILQAGLPANKTVALGSNVEFMCKV 277
++V + R+P+ + V + V+F C
Sbjct: 122 VNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPA 181
Query: 278 YSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEY 337
+P P ++WLK NG + ++ + G ++ ++ + +V D G Y
Sbjct: 182 GGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI-MESVVPSDKGNY 229
Query: 338 TCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKM 397
TC+ N G +H+ L V+ E+ + SP YLEI IYC G FLI+CMV +VI+ +M
Sbjct: 230 TCVVENEYGSINHTYHLDVVAPGREKE-ITASPDYLEIAIYCIGVFLIACMVVTVILCRM 288
Query: 398 KSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSSSG-TPML 455
K+ TKK DF SQ AVHKL K IPLRRQVTVSA+SS+SMNS LVR +RLSS+ TPML
Sbjct: 289 KNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPML 348
Query: 456 AGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK 515
AGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP VAVKMLK
Sbjct: 349 AGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK 408
Query: 516 SDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR 575
DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYL+ARR
Sbjct: 409 DDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR 468
Query: 576 PPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVM 635
PPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVLVTE+NVM
Sbjct: 469 PPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVM 528
Query: 636 KIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLG 695
KIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+WEIFTLG
Sbjct: 529 KIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLG 588
Query: 696 GSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 755
GSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI
Sbjct: 589 GSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 648
Query: 756 VALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANG 815
+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP++P NG
Sbjct: 649 LTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQYPH--ING 705
Query: 816 GLK 818
+K
Sbjct: 706 SVK 708
Score = 272 bits (696), Expect = 8e-73
Identities = 138/253 (54%), Positives = 173/253 (68%), Gaps = 11/253 (4%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 53
M SW + V+ ATL ARPS +L E +P P + E ++ PG+ L++
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 54 RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 113
RC L+D I+W +DGV L +NRT + GE ++++ + P DSGLYAC S S+T Y
Sbjct: 61 RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY 119
Query: 114 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVK 173
F VNV+DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA TVK
Sbjct: 120 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR---APYWTNTEKMEKRLHAVPAANTVK 176
Query: 174 FKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENE 233
F+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VENE
Sbjct: 177 FRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 234 YGSINHTYQLDVV 246
YGSINHTY LDVV
Sbjct: 237 YGSINHTYHLDVV 249
>gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
Length = 705
Score = 702 bits (1813), Expect = 0.0
Identities = 380/670 (56%), Positives = 457/670 (68%), Gaps = 72/670 (10%)
Query: 186 LRWLKNGKEFKPDHR---IGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQ 242
+ W K+G P++R IG Y + + P D G Y C S +
Sbjct: 70 ISWTKDGVHLGPNNRTVLIGEY--------LQIKGATPRDSGLYACTASRTVDSETWYFM 121
Query: 243 LDVVE-------------------------RSPHRPILQAGLPANKTVALGSNVEFMCKV 277
++V + R+P+ + V + V+F C
Sbjct: 122 VNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPA 181
Query: 278 YSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEY 337
+P P ++WLK NG + ++ + G ++ ++ + +V D G Y
Sbjct: 182 GGNPMPTMRWLK----NGKEFKQEH-------RIGGYKVRNQHWSLI-MESVVPSDKGNY 229
Query: 338 TCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSV----- 392
TC+ N G +H+ L V+E RP ++ + L G C V S
Sbjct: 230 TCVVENEYGSINHTYHLDVVERSPHRP-ILQAGLPANASTVVGGDVEFVCKVYSDAQPHI 288
Query: 393 --IVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVR-PSRLSS 449
I + K+G+K +P + + VSA+SS+SMNS LVR +RLSS
Sbjct: 289 QWIKHVEKNGSKYGP-----------DGLPYLKVLKVSAESSSSMNSNTPLVRITTRLSS 337
Query: 450 SG-TPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTK 508
+ TPMLAGVSEYELPEDP+WE PRD+L LGKPLGEGCFGQVV+AEA+G+DKDKP
Sbjct: 338 TADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVT 397
Query: 509 VAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR 568
VAVKMLK DATEKDLSDL+SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR
Sbjct: 398 VAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR 457
Query: 569 EYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVL 628
EYL+ARRPPG+EY Y+ + PEEQ++ KDLVSC YQ+ARGMEYLAS+KCIHRDLAARNVL
Sbjct: 458 EYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVL 517
Query: 629 VTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLL 688
VTE+NVMKIADFGLARDI++IDYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL+
Sbjct: 518 VTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLM 577
Query: 689 WEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQL 748
WEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCTNELYMMMRDCWHAVPSQRPTFKQL
Sbjct: 578 WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQL 637
Query: 749 VEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRH 808
VEDLDRI+ LT+N+EYLDLS PL+QYSPS+PDTRSS CSSG+DSVFS +P+P EPCLP++
Sbjct: 638 VEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSS-CSSGDDSVFSPDPMPYEPCLPQY 696
Query: 809 PAQLANGGLK 818
P NG +K
Sbjct: 697 PH--INGSVK 704
Score = 379 bits (973), Expect = e-105
Identities = 185/324 (57%), Positives = 233/324 (71%), Gaps = 11/324 (3%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQA--QPWGAPVEV-----ESFLVHPGDLLQL 53
M SW + V+ ATL ARPS +L E +P P + E ++ PG+ L++
Sbjct: 1 MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV 60
Query: 54 RCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTY 113
RC L+D I+W +DGV L +NRT + GE ++++ + P DSGLYAC S S+T Y
Sbjct: 61 RCLLKD-AAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWY 119
Query: 114 FSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVK 173
F VNV+DA+ S +D+DD D + E N K APYWT+ EKMEK+LHAVPAA TVK
Sbjct: 120 FMVNVTDAISSGDDEDDTDGAEDFVSENSNNKR---APYWTNTEKMEKRLHAVPAANTVK 176
Query: 174 FKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENE 233
F+CP+ G P PT+RWLKNGKEFK +HRIGGYKVR WS+IM+SVVPSDKGNYTC+VENE
Sbjct: 177 FRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE 236
Query: 234 YGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEV 293
YGSINHTY LDVVERSPHRPILQAGLPAN + +G +VEF+CKVYSD QPHIQW+KH+E
Sbjct: 237 YGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEK 296
Query: 294 NGSKIGPDNLPYVQILKTAGVNTT 317
NGSK GPD LPY+++LK + +++
Sbjct: 297 NGSKYGPDGLPYLKVLKVSAESSS 320
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 634 bits (1636), Expect = 0.0
Identities = 333/547 (60%), Positives = 395/547 (72%), Gaps = 34/547 (6%)
Query: 265 VALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVL 324
V + V F C +P P I WLK NG + ++ + G+ ++ ++
Sbjct: 166 VPAANTVRFRCPAAGNPTPSISWLK----NGREFRGEH-------RIGGIKLRHQQWSLV 214
Query: 325 HLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP-------AVMTSPLYLEIII 377
+ +V D G YTC+ N G + L VLE RP A T+ L ++
Sbjct: 215 -MESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEF 273
Query: 378 YCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS-IPLRRQVTVSADSSASMN 436
+C VY + H ++ K+ P + VS +S+ASM+
Sbjct: 274 HCK-------------VYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMS 320
Query: 437 SGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAI 496
S LVR +RLSS P LA VSE ELP DP+WEL R RL LGKPLGEGCFGQVV+AEAI
Sbjct: 321 SNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAI 380
Query: 497 GLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLY 556
G+DKD+ + VAVKMLK DAT+KDLSDL+SEMEMMKMIGKHKNIINLLGACTQ GPLY
Sbjct: 381 GIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLY 440
Query: 557 VIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKK 616
V+VEYA+KGNLRE+L+ARRPPGL+Y ++ PEEQL+ KDLVSCAYQVARGMEYLAS+K
Sbjct: 441 VLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQK 500
Query: 617 CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYT 676
CIHRDLAARNVLVTEDNVMKIADFGLARD+H++DYYKKTTNGRLPVKWMAPEALFDR+YT
Sbjct: 501 CIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYT 560
Query: 677 HQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH 736
HQSDVWSFGVLLWEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCT++LYM+MR+CWH
Sbjct: 561 HQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWH 620
Query: 737 AVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSH 796
A PSQRPTFKQLVEDLDR++ +TS EYLDLS P +QYSP DT SS+ SSG+DSVF+H
Sbjct: 621 AAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSS-SSGDDSVFAH 679
Query: 797 EPLPEEP 803
+ LP P
Sbjct: 680 DLLPPAP 686
Score = 304 bits (779), Expect = 2e-82
Identities = 149/282 (52%), Positives = 198/282 (70%), Gaps = 10/282 (3%)
Query: 33 PWGAPVEVESFLVHPGDLLQLRCRLRDD--VQSINWLRDGVQLAESNRTRITGEEVEVQD 90
P P + E + GD ++L C + W++DG L S R + + ++V +
Sbjct: 39 PGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLN 98
Query: 91 SVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVA 150
+ DSG Y+C + +FSV V+DA PSS DD+D +D E ++T + A
Sbjct: 99 ASHEDSGAYSC-RQRLTQRVLCHFSVRVTDA-PSSGDDEDGED------EAEDTGVDTGA 150
Query: 151 PYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYAT 210
PYWT PE+M+KKL AVPAA TV+F+CP++G P P++ WLKNG+EF+ +HRIGG K+R+
Sbjct: 151 PYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQ 210
Query: 211 WSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSN 270
WS++M+SVVPSD+GNYTC+VEN++GSI TY LDV+ERSPHRPILQAGLPAN+T LGS+
Sbjct: 211 WSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSD 270
Query: 271 VEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTA 312
VEF CKVYSD QPHIQWLKH+EVNGSK+GPD PYV +LK +
Sbjct: 271 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVS 312
>gi|13186241 fibroblast growth factor receptor 1 isoform 6 precursor
[Homo sapiens]
Length = 300
Score = 405 bits (1040), Expect = e-112
Identities = 191/191 (100%), Positives = 191/191 (100%)
Query: 120 DALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS 179
DALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS
Sbjct: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSS 90
Query: 180 GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINH 239
GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINH
Sbjct: 91 GTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINH 150
Query: 240 TYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG 299
TYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG
Sbjct: 151 TYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG 210
Query: 300 PDNLPYVQILK 310
PDNLPYVQILK
Sbjct: 211 PDNLPYVQILK 221
Score = 86.7 bits (213), Expect = 8e-17
Identities = 67/241 (27%), Positives = 94/241 (39%), Gaps = 70/241 (29%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQ------------------------------ 30
MWSWKCLLFWAVLVTATLCTARPSPTLPEQ
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNPV 60
Query: 31 AQPWGAPVEVESFL--VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAESNR-----TRIT 82
A W +P ++E L V ++ +C ++ WL++G + +R R
Sbjct: 61 APYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA 120
Query: 83 GEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETD 142
+ + VP+D G Y C+ + GS + ++V + P
Sbjct: 121 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPH------------------ 162
Query: 143 NTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLK----NGKEFKPD 198
P+ K V V+F C P P ++WLK NG + PD
Sbjct: 163 ----RPILQAGLPANK------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPD 212
Query: 199 H 199
+
Sbjct: 213 N 213
Score = 43.1 bits (100), Expect = 0.001
Identities = 31/106 (29%), Positives = 46/106 (43%), Gaps = 18/106 (16%)
Query: 259 LPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTD 318
+PA KTV +F C P P ++WLK NG + PD+ + G
Sbjct: 77 VPAAKTV------KFKCPSSGTPNPTLRWLK----NGKEFKPDH-------RIGGYKVRY 119
Query: 319 KEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP 364
++ + +V D G YTC+ N G +H+ L V+E RP
Sbjct: 120 ATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRP 164
>gi|13186238 fibroblast growth factor receptor 1 isoform 5 precursor
[Homo sapiens]
Length = 302
Score = 400 bits (1027), Expect = e-111
Identities = 191/193 (98%), Positives = 191/193 (98%), Gaps = 2/193 (1%)
Query: 120 DALPSSEDDDDDDDSSSEEKETDNTKPN--PVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 177
DALPSSEDDDDDDDSSSEEKETDNTKPN PVAPYWTSPEKMEKKLHAVPAAKTVKFKCP
Sbjct: 31 DALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP 90
Query: 178 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 237
SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI
Sbjct: 91 SSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSI 150
Query: 238 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 297
NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK
Sbjct: 151 NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSK 210
Query: 298 IGPDNLPYVQILK 310
IGPDNLPYVQILK
Sbjct: 211 IGPDNLPYVQILK 223
Score = 85.9 bits (211), Expect = 1e-16
Identities = 67/243 (27%), Positives = 94/243 (38%), Gaps = 72/243 (29%)
Query: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQ------------------------------ 30
MWSWKCLLFWAVLVTATLCTARPSPTLPEQ
Sbjct: 1 MWSWKCLLFWAVLVTATLCTARPSPTLPEQDALPSSEDDDDDDDSSSEEKETDNTKPNRM 60
Query: 31 --AQPWGAPVEVESFL--VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAESNR-----TR 80
A W +P ++E L V ++ +C ++ WL++G + +R R
Sbjct: 61 PVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR 120
Query: 81 ITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKE 140
+ + VP+D G Y C+ + GS + ++V + P
Sbjct: 121 YATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPH---------------- 164
Query: 141 TDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLK----NGKEFK 196
P+ K V V+F C P P ++WLK NG +
Sbjct: 165 ------RPILQAGLPANK------TVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIG 212
Query: 197 PDH 199
PD+
Sbjct: 213 PDN 215
Score = 43.1 bits (100), Expect = 0.001
Identities = 31/106 (29%), Positives = 46/106 (43%), Gaps = 18/106 (16%)
Query: 259 LPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTD 318
+PA KTV +F C P P ++WLK NG + PD+ + G
Sbjct: 79 VPAAKTV------KFKCPSSGTPNPTLRWLK----NGKEFKPDH-------RIGGYKVRY 121
Query: 319 KEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP 364
++ + +V D G YTC+ N G +H+ L V+E RP
Sbjct: 122 ATWSII-MDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRP 166
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 334 bits (857), Expect = 2e-91
Identities = 239/652 (36%), Positives = 328/652 (50%), Gaps = 142/652 (21%)
Query: 222 DKGNYTCIVENEYGSINHTY--QLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYS 279
D+G+Y C+ ++ H QL V+ER P + L N+T ++G ++E C
Sbjct: 636 DQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIGESIEVSCTASG 692
Query: 280 DPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTC 339
+P P I W K E +++ +G+ D L +R V ED G YTC
Sbjct: 693 NPPPQIMWFKDNET--------------LVEDSGIVLKDGNRN-LTIRRVRKEDEGLYTC 737
Query: 340 LAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKS 399
A + +G + A+ ++E +E+ LEIII G +I+ ++V ++
Sbjct: 738 QACSVLGCAKVEAFF-IIEGAQEKTN-------LEIIIL-VGTAVIAMFFWLLLVIILR- 787
Query: 400 GTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVL--LVRPSRLSSSGTPMLAG 457
TV + + +G L ++ P L
Sbjct: 788 --------------------------TVKRANGGELKTGYLSIVMDPDELP--------- 812
Query: 458 VSEY--ELPEDP-RWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML 514
+ E+ LP D +WE PRDRL LGKPLG G FGQV+ A+A G+DK R VAVKML
Sbjct: 813 LDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRT--VAVKML 870
Query: 515 KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDG-PLYVIVEYASKGNLREYLQ- 572
K AT + L+SE++++ IG H N++NLLGACT+ G PL VIVE+ GNL YL+
Sbjct: 871 KEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRS 930
Query: 573 ------------ARRPPGLEYC---------------------------------YNPSH 587
AR G +Y
Sbjct: 931 KRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEE 990
Query: 588 NPEEQ----LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLA 643
PE+ L+ + L+ ++QVA+GME+LAS+KCIHRDLAARN+L++E NV+KI DFGLA
Sbjct: 991 APEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLA 1050
Query: 644 RDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVP 703
RDI+ Y + + RLP+KWMAPE +FDR+YT QSDVWSFGVLLWEIF+LG SPYPGV
Sbjct: 1051 RDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVK 1110
Query: 704 VEELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 762
++E F + LKEG RM P T E+Y M DCWH PSQRPTF +LVE L ++ + Q
Sbjct: 1111 IDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQ 1170
Query: 763 EYLD-LSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLP------EEPCLPR 807
+ D + +P+ S T S EDS S P EE C P+
Sbjct: 1171 DGKDYIVLPI-----------SETLSMEEDSGLSLPTSPVSCMEEEEVCDPK 1211
Score = 45.1 bits (105), Expect = 3e-04
Identities = 35/143 (24%), Positives = 58/143 (40%), Gaps = 8/143 (5%)
Query: 151 PYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYAT 210
P+ ME + A + V+ G P P ++W KNG + +H I V
Sbjct: 328 PFVAFGSGMESLVEAT-VGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHV---- 382
Query: 211 WSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSN 270
+ + V D GNYT I+ N ++ + +V P + ++ + + G+
Sbjct: 383 --LTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTT 440
Query: 271 VEFMCKVYSDPQP-HIQWLKHIE 292
C VY+ P P HI W +E
Sbjct: 441 QTLTCTVYAIPPPHHIHWYWQLE 463
Score = 37.4 bits (85), Expect = 0.057
Identities = 36/142 (25%), Positives = 55/142 (38%), Gaps = 24/142 (16%)
Query: 212 SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQ--AGLPANKTVALGS 269
++ +D V SD+G YTC + + ++ + V E+ P + +G+ + +G
Sbjct: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
Query: 270 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 329
V K P P I+W K NG + N T K VL + V
Sbjct: 347 RVRIPAKYLGYPPPEIKWYK----NGIPLES--------------NHTIKAGHVLTIMEV 388
Query: 330 SFEDAGEYTCLAGNSIGLSHHS 351
S D G YT + N I S
Sbjct: 389 SERDTGNYTVILTNPISKEKQS 410
Score = 35.8 bits (81), Expect = 0.17
Identities = 68/329 (20%), Positives = 120/329 (36%), Gaps = 61/329 (18%)
Query: 64 INWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALP 123
I W ++G+ L ESN T G + + + D+G Y + ++P + V++ +P
Sbjct: 362 IKWYKNGIPL-ESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVP 420
Query: 124 SSEDDDD-DDDSSSEEKETDNT---------KPNPVAPYWTSPEKMEKKLHAVPAAKTVK 173
+ S + T T P+ + YW ++E++ P+
Sbjct: 421 PQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYW----QLEEECANEPS----- 471
Query: 174 FKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYA-------TWSIIMDSVVPSDKGNY 226
+ S P P W ++ ++F+ ++I K ++A T S ++ + Y
Sbjct: 472 -QAVSVTNPYPCEEW-RSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAA-NVSALY 528
Query: 227 TCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQ 286
C N+ G V R P + P + +V C ++
Sbjct: 529 KCEAVNKVGRGERVISFHVT-RGPEITLQPDMQPTEQ-----ESVSLWCTADRSTFENLT 582
Query: 287 WLKHIEVNGSKIGPDNLP-YVQILKTAGVNTTD--------------KEMEVLHLRNVSF 331
W K +GP LP +V L T D ++ ++ L+N S
Sbjct: 583 WYK--------LGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASL 634
Query: 332 EDAGEYTCLAGNSIGLSHHSA--WLTVLE 358
+D G+Y CLA + H LTVLE
Sbjct: 635 QDQGDYVCLAQDRKTKKRHCVVRQLTVLE 663
Score = 32.7 bits (73), Expect = 1.4
Identities = 15/59 (25%), Positives = 29/59 (49%), Gaps = 3/59 (5%)
Query: 170 KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTC 228
++++ C +SG P P + W K+ + D G ++ ++ + V D+G YTC
Sbjct: 682 ESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNLTIRRVRKEDEGLYTC 737
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 328 bits (840), Expect = 2e-89
Identities = 181/396 (45%), Positives = 248/396 (62%), Gaps = 30/396 (7%)
Query: 382 AFLISCMVGSVIVYKMKSGTKKSDFHS-QMAVHKLAKSIPLRRQVTVSADSSASMNSGVL 440
+F++S ++ + ++ K S +M + A++ P VS SS +
Sbjct: 645 SFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFP------VSYSSSGAR----- 693
Query: 441 LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK 500
RPS S V +++ EDP+WE PR LVLGK LGEG FG+VV A A L K
Sbjct: 694 --RPSLDSMENQ---VSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-K 747
Query: 501 DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 560
+ T VAVKMLK +A+ +L DL+SE ++K + H ++I L GAC+QDGPL +IVE
Sbjct: 748 GRAGYTT-VAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVE 805
Query: 561 YASKGNLREYLQARRPPGLEYCYNPS--------HNPEEQLSSKDLVSCAYQVARGMEYL 612
YA G+LR +L+ R G Y + H E L+ DL+S A+Q+++GM+YL
Sbjct: 806 YAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL 865
Query: 613 ASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFD 672
A K +HRDLAARN+LV E MKI+DFGL+RD++ D Y K + GR+PVKWMA E+LFD
Sbjct: 866 AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFD 925
Query: 673 RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMR 732
IYT QSDVWSFGVLLWEI TLGG+PYPG+P E LF LLK GHRM++P NC+ E+Y +M
Sbjct: 926 HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLML 985
Query: 733 DCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLS 768
CW P +RP F + +DL+++ + ++YLDL+
Sbjct: 986 QCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLA 1019
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 328 bits (840), Expect = 2e-89
Identities = 181/396 (45%), Positives = 248/396 (62%), Gaps = 30/396 (7%)
Query: 382 AFLISCMVGSVIVYKMKSGTKKSDFHS-QMAVHKLAKSIPLRRQVTVSADSSASMNSGVL 440
+F++S ++ + ++ K S +M + A++ P VS SS +
Sbjct: 645 SFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFP------VSYSSSGAR----- 693
Query: 441 LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK 500
RPS S V +++ EDP+WE PR LVLGK LGEG FG+VV A A L K
Sbjct: 694 --RPSLDSMENQ---VSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-K 747
Query: 501 DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 560
+ T VAVKMLK +A+ +L DL+SE ++K + H ++I L GAC+QDGPL +IVE
Sbjct: 748 GRAGYTT-VAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVE 805
Query: 561 YASKGNLREYLQARRPPGLEYCYNPS--------HNPEEQLSSKDLVSCAYQVARGMEYL 612
YA G+LR +L+ R G Y + H E L+ DL+S A+Q+++GM+YL
Sbjct: 806 YAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL 865
Query: 613 ASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFD 672
A K +HRDLAARN+LV E MKI+DFGL+RD++ D Y K + GR+PVKWMA E+LFD
Sbjct: 866 AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFD 925
Query: 673 RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMR 732
IYT QSDVWSFGVLLWEI TLGG+PYPG+P E LF LLK GHRM++P NC+ E+Y +M
Sbjct: 926 HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLML 985
Query: 733 DCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLS 768
CW P +RP F + +DL+++ + ++YLDL+
Sbjct: 986 QCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLA 1019
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
sapiens]
Length = 1338
Score = 321 bits (822), Expect = 2e-87
Identities = 219/613 (35%), Positives = 307/613 (50%), Gaps = 118/613 (19%)
Query: 210 TWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS 269
T ++ + +V D G Y C N Y + ++ R P L L ++ TVA+ S
Sbjct: 618 TLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISS 676
Query: 270 NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 329
+ C P+P I W K N KI + I+ G +T L + V
Sbjct: 677 STTLDCHANGVPEPQITWFK----NNHKIQQEP----GIILGPGSST-------LFIERV 721
Query: 330 SFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV 389
+ ED G Y C A N G SA+LTV ++ + + + C A L ++
Sbjct: 722 TEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLEL-----ITLTCTCVAATLFWLLL 776
Query: 390 GSVIVYKMKSGTK--KSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRL 447
++ + KMK + K+D+ +++ +PL Q
Sbjct: 777 -TLFIRKMKRSSSEIKTDY---LSIIMDPDEVPLDEQCE--------------------- 811
Query: 448 SSSGTPMLAGVSEYELPEDP-RWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV 506
LP D +WE R+RL LGK LG G FG+VV A A G+ K R
Sbjct: 812 --------------RLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRT 857
Query: 507 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKG 565
VAVKMLK AT + L++E++++ IG H N++NLLGACT Q GPL VIVEY G
Sbjct: 858 --VAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYG 915
Query: 566 NLREYLQARRP--------------------PGLEYCYNPSHNP---------------- 589
NL YL+++R PGLE P +
Sbjct: 916 NLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDK 975
Query: 590 ---------------EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV 634
+E ++ +DL+S ++QVARGME+L+S+KCIHRDLAARN+L++E+NV
Sbjct: 976 SLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNV 1035
Query: 635 MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTL 694
+KI DFGLARDI+ Y + + RLP+KWMAPE++FD+IY+ +SDVWS+GVLLWEIF+L
Sbjct: 1036 VKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSL 1095
Query: 695 GGSPYPGVPVEELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD 753
GGSPYPGV ++E F L+EG RM P T E+Y +M DCWH P +RP F +LVE L
Sbjct: 1096 GGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLG 1155
Query: 754 RIVALTSNQEYLD 766
++ Q+ D
Sbjct: 1156 DLLQANVQQDGKD 1168
Score = 47.4 bits (111), Expect = 5e-05
Identities = 35/143 (24%), Positives = 59/143 (41%), Gaps = 14/143 (9%)
Query: 154 TSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYAT--W 211
T + ++ L V ++ + P+P + WLK+G RY T +
Sbjct: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEK------SARYLTRGY 388
Query: 212 SIIMDSVVPSDKGNYTCIVE----NEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL 267
S+I+ V D GNYT ++ N + ++ T ++V + + + + P L
Sbjct: 389 SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPL 446
Query: 268 GSNVEFMCKVYSDPQPHIQWLKH 290
GS C Y PQP I+W H
Sbjct: 447 GSRQILTCTAYGIPQPTIKWFWH 469
Score = 40.8 bits (94), Expect = 0.005
Identities = 20/82 (24%), Positives = 38/82 (46%), Gaps = 3/82 (3%)
Query: 164 HAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDK 223
H V + + C ++G P P + W KN + + + G + + ++ ++ V D+
Sbjct: 670 HTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQE---PGIILGPGSSTLFIERVTEEDE 726
Query: 224 GNYTCIVENEYGSINHTYQLDV 245
G Y C N+ GS+ + L V
Sbjct: 727 GVYHCKATNQKGSVESSAYLTV 748
Score = 35.0 bits (79), Expect = 0.28
Identities = 38/134 (28%), Positives = 59/134 (44%), Gaps = 29/134 (21%)
Query: 213 IIMDSVVPSDKGNYTCIVEN--EYGSIN---HTY-QLDVVERSPHRPILQAGLPANKTVA 266
+ +D + DKG YTC V + + S+N H Y + + + + +L+ TVA
Sbjct: 296 LTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLE-------TVA 348
Query: 267 LGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHL 326
+ KV + P P + WLK D LP + K+A T L +
Sbjct: 349 GKRSYRLSMKVKAFPSPEVVWLK-----------DGLPATE--KSARYLTRGYS---LII 392
Query: 327 RNVSFEDAGEYTCL 340
++V+ EDAG YT L
Sbjct: 393 KDVTEEDAGNYTIL 406
>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 2 precursor [Homo sapiens]
Length = 972
Score = 269 bits (688), Expect = 7e-72
Identities = 212/688 (30%), Positives = 321/688 (46%), Gaps = 156/688 (22%)
Query: 212 SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL--GS 269
++ + S +D G + C N +GS N T L+VV++ + N TV + G
Sbjct: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
Query: 270 NVEFMCKVYSDPQP-HIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRN 328
NV+ + + + P+P H QW+ K ++ P + + + + LHL
Sbjct: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKW--EDYP------KSENESNIRYVSELHLTR 381
Query: 329 VSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCM 388
+ + G YT L N S +A + + +P ++T + ++ C A
Sbjct: 382 LKGTEGGTYTFLVSN----SDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPE-- 435
Query: 389 VGSVIVYKMKSGTKKSDFHSQMA--VHKLAKSIPLRRQVTV--SADSSASMNSGVL---- 440
I + GT++ S + V L S P ++ V S DSSA ++G +
Sbjct: 436 --PTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKA 493
Query: 441 -----------------LVRPSRLSSSGTPMLAG-------------VSEYELPEDPRWE 470
+ P L TP+L G + Y+ + P +E
Sbjct: 494 YNDVGKTSAYFNFAFKEQIHPHTLF---TPLLIGFVIVAGMMCIIVMILTYKYLQKPMYE 550
Query: 471 ---------------------LPRD--------RLVLGKPLGEGCFGQVVLAEAIGLDKD 501
LP D RL GK LG G FG+VV A A GL K
Sbjct: 551 VQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKS 610
Query: 502 KPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 561
+ VAVKMLK A + L+SE++++ +G H NI+NLLGACT GP VI EY
Sbjct: 611 --DAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEY 668
Query: 562 ASKGNLREYLQARR--------------------------------------PPGLEYC- 582
G+L +L+ +R PG+ Y
Sbjct: 669 CCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVV 728
Query: 583 -------------------YNPSHNPEEQLS--SKDLVSCAYQVARGMEYLASKKCIHRD 621
P+ +++L+ +DL+S +YQVA+GM +LASK CIHRD
Sbjct: 729 PTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRD 788
Query: 622 LAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV 681
LAARN+L+T + KI DFGLARDI + Y N RLPVKWMAPE++F+ +YT +SDV
Sbjct: 789 LAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDV 848
Query: 682 WSFGVLLWEIFTLGGSPYPGVPVE-ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPS 740
WS+G+ LWE+F+LG SPYPG+PV+ + +K++KEG RM P + E+Y +M+ CW A P
Sbjct: 849 WSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPL 908
Query: 741 QRPTFKQLVEDLDRIVALTSNQEYLDLS 768
+RPTFKQ+V+ +++ ++ ++N Y +L+
Sbjct: 909 KRPTFKQIVQLIEKQISESTNHIYSNLA 936
>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 1 precursor [Homo sapiens]
Length = 976
Score = 268 bits (684), Expect = 2e-71
Identities = 150/370 (40%), Positives = 209/370 (56%), Gaps = 67/370 (18%)
Query: 462 ELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK 521
+LP D +WE PR+RL GK LG G FG+VV A A GL K + VAVKMLK A
Sbjct: 575 QLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKS--DAAMTVAVKMLKPSAHLT 632
Query: 522 DLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIV---------------------- 559
+ L+SE++++ +G H NI+NLLGACT GP VI
Sbjct: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692
Query: 560 ------------------EYASKGNLREYLQARRPPGLEYCYNPS--------------- 586
E + + EY+ + PG+ Y
Sbjct: 693 KQEDHAEAALYKNLLHSKESSCSDSTNEYMDMK--PGVSYVVPTKADKRRSVRIGSYIER 750
Query: 587 -------HNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIAD 639
+ E L +DL+S +YQVA+GM +LASK CIHRDLAARN+L+T + KI D
Sbjct: 751 DVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICD 810
Query: 640 FGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 699
FGLARDI + Y N RLPVKWMAPE++F+ +YT +SDVWS+G+ LWE+F+LG SPY
Sbjct: 811 FGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPY 870
Query: 700 PGVPVE-ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVAL 758
PG+PV+ + +K++KEG RM P + E+Y +M+ CW A P +RPTFKQ+V+ +++ ++
Sbjct: 871 PGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISE 930
Query: 759 TSNQEYLDLS 768
++N Y +L+
Sbjct: 931 STNHIYSNLA 940
Score = 37.0 bits (84), Expect = 0.074
Identities = 39/174 (22%), Positives = 73/174 (41%), Gaps = 19/174 (10%)
Query: 212 SIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVAL--GS 269
++ + S +D G + C N +GS N T L+VV++ + N TV + G
Sbjct: 274 TLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKG----FINIFPMINTTVFVNDGE 329
Query: 270 NVEFMCKVYSDPQP-HIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRN 328
NV+ + + + P+P H QW+ K ++ P + + + + LHL
Sbjct: 330 NVDLIVEYEAFPKPEHQQWIYMNRTFTDKW--EDYP------KSENESNIRYVSELHLTR 381
Query: 329 VSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGA 382
+ + G YT L N S +A + + +P ++T + ++ C A
Sbjct: 382 LKGTEGGTYTFLVSN----SDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAA 431
>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
domains 1 [Homo sapiens]
Length = 1138
Score = 250 bits (638), Expect = 4e-66
Identities = 137/288 (47%), Positives = 185/288 (64%), Gaps = 10/288 (3%)
Query: 482 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 541
+GEG FGQV+ A I D K N A+KMLK A+E D D E+E++ +G H N
Sbjct: 845 IGEGNFGQVIRA-MIKKDGLKMN----AAIKMLKEYASENDHRDFAGELEVLCKLGHHPN 899
Query: 542 IINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSC 601
IINLLGAC G LY+ +EYA GNL ++L+ R + + H LSS+ L+
Sbjct: 900 IINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRF 959
Query: 602 AYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLP 661
A A GM+YL+ K+ IHRDLAARNVLV E+ KIADFGL+R + Y K T GRLP
Sbjct: 960 ASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRG---EEVYVKKTMGRLP 1016
Query: 662 VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPS 721
V+WMA E+L +YT +SDVWSFGVLLWEI +LGG+PY G+ EL++ L +G+RM++P
Sbjct: 1017 VRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPR 1076
Query: 722 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSM 769
NC +E+Y +MR CW P +RP F Q+ L R+ L + + Y+++S+
Sbjct: 1077 NCDDEVYELMRQCWRDRPYERPPFAQIALQLGRM--LEARKAYVNMSL 1122
Score = 32.3 bits (72), Expect = 1.8
Identities = 17/37 (45%), Positives = 20/37 (54%)
Query: 82 TGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNV 118
T E EV V ADSG + C S+ G D+ F VNV
Sbjct: 407 TTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNV 443
>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
Length = 1124
Score = 244 bits (622), Expect = 3e-64
Identities = 128/275 (46%), Positives = 180/275 (65%), Gaps = 8/275 (2%)
Query: 482 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 541
+GEG FGQV+ A K A+K +K A++ D D E+E++ +G H N
Sbjct: 830 IGEGNFGQVLKARI-----KKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
Query: 542 IINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSC 601
IINLLGAC G LY+ +EYA GNL ++L+ R + + +++ LSS+ L+
Sbjct: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
Query: 602 AYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLP 661
A VARGM+YL+ K+ IHRDLAARN+LV E+ V KIADFGL+R + Y K T GRLP
Sbjct: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVYVKKTMGRLP 1001
Query: 662 VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPS 721
V+WMA E+L +YT SDVWS+GVLLWEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
Query: 722 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 756
NC +E+Y +MR CW P +RP+F Q++ L+R++
Sbjct: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRML 1096
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,963,590
Number of Sequences: 37866
Number of extensions: 1754542
Number of successful extensions: 15441
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 702
Number of HSP's successfully gapped in prelim test: 427
Number of HSP's that attempted gapping in prelim test: 7956
Number of HSP's gapped (non-prelim): 4082
length of query: 820
length of database: 18,247,518
effective HSP length: 111
effective length of query: 709
effective length of database: 14,044,392
effective search space: 9957473928
effective search space used: 9957473928
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.