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Search of human proteins with 4507831
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4507831 Unc-51-like kinase 1 [Homo sapiens]
(1050 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4507831 Unc-51-like kinase 1 [Homo sapiens] 2107 0.0
gi|217330559 unc-51-like kinase 2 [Homo sapiens] 946 0.0
gi|217330557 unc-51-like kinase 2 [Homo sapiens] 946 0.0
gi|150456432 unc-51-like kinase 3 [Homo sapiens] 199 9e-51
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 164 3e-40
gi|41872374 polo-like kinase 3 [Homo sapiens] 159 2e-38
gi|121114283 polo-like kinase 4 [Homo sapiens] 155 1e-37
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 153 7e-37
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 152 1e-36
gi|156105707 SNF related kinase [Homo sapiens] 152 2e-36
gi|156105705 SNF related kinase [Homo sapiens] 152 2e-36
gi|23943882 serine/threonine kinase 33 [Homo sapiens] 151 4e-36
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 149 1e-35
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 149 1e-35
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 149 1e-35
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 149 1e-35
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 149 2e-35
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 148 2e-35
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 148 3e-35
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 148 3e-35
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 148 3e-35
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 148 3e-35
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens] 145 1e-34
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 144 3e-34
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 144 3e-34
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 144 3e-34
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 144 3e-34
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 144 3e-34
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 144 3e-34
gi|38327572 serine/threonine protein kinase 6 [Homo sapiens] 144 6e-34
>gi|4507831 Unc-51-like kinase 1 [Homo sapiens]
Length = 1050
Score = 2107 bits (5460), Expect = 0.0
Identities = 1050/1050 (100%), Positives = 1050/1050 (100%)
Query: 1 MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLL 60
MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLL
Sbjct: 1 MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLL 60
Query: 61 GKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQ 120
GKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQ
Sbjct: 61 GKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQ 120
Query: 121 QIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT 180
QIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT
Sbjct: 121 QIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT 180
Query: 181 LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLV 240
LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLV
Sbjct: 181 LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLV 240
Query: 241 PTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGS 300
PTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGS
Sbjct: 241 PTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGS 300
Query: 301 GSSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMV 360
GSSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMV
Sbjct: 301 GSSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMV 360
Query: 361 PAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGP 420
PAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGP
Sbjct: 361 PAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGP 420
Query: 421 FSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSP 480
FSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSP
Sbjct: 421 FSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSP 480
Query: 481 PAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSA 540
PAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSA
Sbjct: 481 PAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSA 540
Query: 541 PEHSPRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPLGAVFSPPQASPPQPSHGLQSCR 600
PEHSPRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPLGAVFSPPQASPPQPSHGLQSCR
Sbjct: 541 PEHSPRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPLGAVFSPPQASPPQPSHGLQSCR 600
Query: 601 NLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRT 660
NLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRT
Sbjct: 601 NLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRT 660
Query: 661 LPDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESL 720
LPDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESL
Sbjct: 661 LPDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESL 720
Query: 721 QEKPMEIAPSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSGSTPPQGPRTRMFSAGPTG 780
QEKPMEIAPSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSGSTPPQGPRTRMFSAGPTG
Sbjct: 721 QEKPMEIAPSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSGSTPPQGPRTRMFSAGPTG 780
Query: 781 SASSSARHLVPGPCSEAPAPELPAPGHGCSFADPIAANLEGAVTFEAPDLPEETLMEQEH 840
SASSSARHLVPGPCSEAPAPELPAPGHGCSFADPIAANLEGAVTFEAPDLPEETLMEQEH
Sbjct: 781 SASSSARHLVPGPCSEAPAPELPAPGHGCSFADPIAANLEGAVTFEAPDLPEETLMEQEH 840
Query: 841 TEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGFAEQL 900
TEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGFAEQL
Sbjct: 841 TEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGFAEQL 900
Query: 901 VLYLKVAELLSSGLQSAIDQIRAGKLCLSSTVKQVVRRLNELYKASVVSCQGLSLRLQRF 960
VLYLKVAELLSSGLQSAIDQIRAGKLCLSSTVKQVVRRLNELYKASVVSCQGLSLRLQRF
Sbjct: 901 VLYLKVAELLSSGLQSAIDQIRAGKLCLSSTVKQVVRRLNELYKASVVSCQGLSLRLQRF 960
Query: 961 FLDKQRLLDRIHSITAERLIFSHAVQMVQSAALDEMFQHREGCVPRYHKALLLLEGLQHM 1020
FLDKQRLLDRIHSITAERLIFSHAVQMVQSAALDEMFQHREGCVPRYHKALLLLEGLQHM
Sbjct: 961 FLDKQRLLDRIHSITAERLIFSHAVQMVQSAALDEMFQHREGCVPRYHKALLLLEGLQHM 1020
Query: 1021 LSDQADIENVTKCKLCIERRLSALLTGICA 1050
LSDQADIENVTKCKLCIERRLSALLTGICA
Sbjct: 1021 LSDQADIENVTKCKLCIERRLSALLTGICA 1050
>gi|217330559 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 946 bits (2446), Expect = 0.0
Identities = 565/1079 (52%), Positives = 686/1079 (63%), Gaps = 94/1079 (8%)
Query: 9 ETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILK 68
E VG FE+S++DL+GHGAFAVVF+GRHR+K D EVA+K INKKNL+KSQ LLGKEIKILK
Sbjct: 2 EVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILK 61
Query: 69 ELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRL 128
EL+HENIVALYD QE+ NSV+LVMEYCNGGDLADYL A TLSEDTIR+FL QIA AMR+
Sbjct: 62 ELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRI 121
Query: 129 LHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYM 188
LHSKGIIHRDLKPQNILLS R+++ + IR+KIADFGFARYL SNMMAATLCGSPMYM
Sbjct: 122 LHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYM 181
Query: 189 APEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETS 248
APEVIMSQHYD KADLWSIGT++YQCL GK PFQA+SPQDLR+FYEKN++L+P+IPRETS
Sbjct: 182 APEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETS 241
Query: 249 APLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGSGSSSSSSS 308
L LLL LLQRN KDRMDF+ FF HPFL+ P V+KS PVPVP Y S SGSS SS
Sbjct: 242 PYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGP-VKKSCPVPVPMYSGSVSGSSCGSSP 300
Query: 309 TSHLASPPSLGEMQQLQKTLAS--PADTAGFLHSSRDSG--GSKDSSCDTDDFVMVPAQF 364
+ ASPPSL +MQ +Q+ S P +L S+DS SK+SSCDTDDFV+VP
Sbjct: 301 SCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDDFVLVPHNI 360
Query: 365 PGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSS 424
D + P V +AG + C + SP
Sbjct: 361 SSDHSCDMP----------------VGTAGRRASNEFLVCGGQCQPTVSPHSE------- 397
Query: 425 RCGASVPIPVPTQVQNYQRIERNLQSPTQFQT-----PRSSAIRRSGSTSPLGFARASPS 479
+ PIPVPTQ++NYQRIE+NL S T PRS+ +RRS +TSP+GF R
Sbjct: 398 ----TAPIPVPTQIRNYQRIEQNLTSTASSGTNVHGSPRSAVVRRS-NTSPMGFLRPGSC 452
Query: 480 PPAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSS 539
P A+ + R++S G RPY+PSP VGTIPE+ PQG + R S GS
Sbjct: 453 SPVPADTAQTVGRRLSTGSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNS--SGSP 510
Query: 540 APE-HSPRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPL-----GAVFS-PPQASPPQP 592
P+ SP++ G RL SAP L+D++ + KL K +DP+ GA +S PQ S P
Sbjct: 511 VPQAQSPQSLLSGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSPQPSRP-G 569
Query: 593 SHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVV 652
S G ++L SP+ D+ + PLP I+GSPTK F PKT +S NLLAL+ R G
Sbjct: 570 SLGTSPTKHLGSSPRSSDWFFKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVTRHG-- 627
Query: 653 MTPPRNRTLPDLSEVGPFHGQPLGPG---LRPGEDPKGPFGRSFSTSRLTDLLLKAAFGT 709
P D +E L G R + K FGRS ST +L+D K
Sbjct: 628 ---PAEEQSKDGNEPRECAHCLLVQGSERQRAEQQSKAVFGRSVSTGKLSDQQGKTPI-- 682
Query: 710 QAPDPGSTESLQ-EKPMEIAPSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSGSTPPQG 768
GST+SL E+PM+IAP+ GG L P AG +S V+FTVGSPP + P
Sbjct: 683 -CRHQGSTDSLNTERPMDIAPAGACGGVLAP--PAGTAASSKAVLFTVGSPPHSAAAPTC 739
Query: 769 P----RTRMFSAGPTGSASS----SARHLVPGPCSEAPAPELPAPGHGCSFADPIAA--- 817
RTR S GP+ S S S R V P P PG G S AA
Sbjct: 740 THMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSP---------PGPGFGSSPPGAEAAPSL 790
Query: 818 ----------NLEGAVTFEAPDLPEETLMEQEHTEILRGLRFTLLFVQHVLEIAALKGSA 867
+LEG +TFEAP+LPEETLME+EHT+ LR L L+F + VL++ A++G
Sbjct: 791 RYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECVLDLTAMRGGN 850
Query: 868 SE--AAGGPEYQLQESVVADQISLLSREWGFAEQLVLYLKVAELLSSGLQSAIDQIRAGK 925
E + YQ+QESVV DQIS LS++WG EQLVLY+K A+LL++ L A QI++GK
Sbjct: 851 PELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGK 910
Query: 926 LCLSSTVKQVVRRLNELYKASVVSCQGLSLRLQRFFLDKQRLLDRIHSITAERLIFSHAV 985
L S+ VKQVV+ LNE YK + C+ L+ +L RFF DKQR +D I+S+TAE+LI++ AV
Sbjct: 911 LSPSTAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVTAEKLIYNCAV 970
Query: 986 QMVQSAALDEMFQHREGCVPRYHKALLLLEGLQHMLSDQADIENVTKCKLCIERRLSAL 1044
+MVQSAALDEMFQ E V RYHKA LLLEGL +L D ADIENV K K IERRLSAL
Sbjct: 971 EMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDPADIENVHKYKCSIERRLSAL 1029
>gi|217330557 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 946 bits (2446), Expect = 0.0
Identities = 565/1079 (52%), Positives = 686/1079 (63%), Gaps = 94/1079 (8%)
Query: 9 ETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILK 68
E VG FE+S++DL+GHGAFAVVF+GRHR+K D EVA+K INKKNL+KSQ LLGKEIKILK
Sbjct: 2 EVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILK 61
Query: 69 ELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRL 128
EL+HENIVALYD QE+ NSV+LVMEYCNGGDLADYL A TLSEDTIR+FL QIA AMR+
Sbjct: 62 ELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRI 121
Query: 129 LHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYM 188
LHSKGIIHRDLKPQNILLS R+++ + IR+KIADFGFARYL SNMMAATLCGSPMYM
Sbjct: 122 LHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYM 181
Query: 189 APEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETS 248
APEVIMSQHYD KADLWSIGT++YQCL GK PFQA+SPQDLR+FYEKN++L+P+IPRETS
Sbjct: 182 APEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETS 241
Query: 249 APLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGSGSSSSSSS 308
L LLL LLQRN KDRMDF+ FF HPFL+ P V+KS PVPVP Y S SGSS SS
Sbjct: 242 PYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQGP-VKKSCPVPVPMYSGSVSGSSCGSSP 300
Query: 309 TSHLASPPSLGEMQQLQKTLAS--PADTAGFLHSSRDSG--GSKDSSCDTDDFVMVPAQF 364
+ ASPPSL +MQ +Q+ S P +L S+DS SK+SSCDTDDFV+VP
Sbjct: 301 SCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSKDSASTSSKNSSCDTDDFVLVPHNI 360
Query: 365 PGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSS 424
D + P V +AG + C + SP
Sbjct: 361 SSDHSCDMP----------------VGTAGRRASNEFLVCGGQCQPTVSPHSE------- 397
Query: 425 RCGASVPIPVPTQVQNYQRIERNLQSPTQFQT-----PRSSAIRRSGSTSPLGFARASPS 479
+ PIPVPTQ++NYQRIE+NL S T PRS+ +RRS +TSP+GF R
Sbjct: 398 ----TAPIPVPTQIRNYQRIEQNLTSTASSGTNVHGSPRSAVVRRS-NTSPMGFLRPGSC 452
Query: 480 PPAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSS 539
P A+ + R++S G RPY+PSP VGTIPE+ PQG + R S GS
Sbjct: 453 SPVPADTAQTVGRRLSTGSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNS--SGSP 510
Query: 540 APE-HSPRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPL-----GAVFS-PPQASPPQP 592
P+ SP++ G RL SAP L+D++ + KL K +DP+ GA +S PQ S P
Sbjct: 511 VPQAQSPQSLLSGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSPQPSRP-G 569
Query: 593 SHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVV 652
S G ++L SP+ D+ + PLP I+GSPTK F PKT +S NLLAL+ R G
Sbjct: 570 SLGTSPTKHLGSSPRSSDWFFKTPLPTIIGSPTKTTAPFKIPKTQASSNLLALVTRHG-- 627
Query: 653 MTPPRNRTLPDLSEVGPFHGQPLGPG---LRPGEDPKGPFGRSFSTSRLTDLLLKAAFGT 709
P D +E L G R + K FGRS ST +L+D K
Sbjct: 628 ---PAEEQSKDGNEPRECAHCLLVQGSERQRAEQQSKAVFGRSVSTGKLSDQQGKTPI-- 682
Query: 710 QAPDPGSTESLQ-EKPMEIAPSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSGSTPPQG 768
GST+SL E+PM+IAP+ GG L P AG +S V+FTVGSPP + P
Sbjct: 683 -CRHQGSTDSLNTERPMDIAPAGACGGVLAP--PAGTAASSKAVLFTVGSPPHSAAAPTC 739
Query: 769 P----RTRMFSAGPTGSASS----SARHLVPGPCSEAPAPELPAPGHGCSFADPIAA--- 817
RTR S GP+ S S S R V P P PG G S AA
Sbjct: 740 THMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSP---------PGPGFGSSPPGAEAAPSL 790
Query: 818 ----------NLEGAVTFEAPDLPEETLMEQEHTEILRGLRFTLLFVQHVLEIAALKGSA 867
+LEG +TFEAP+LPEETLME+EHT+ LR L L+F + VL++ A++G
Sbjct: 791 RYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECVLDLTAMRGGN 850
Query: 868 SE--AAGGPEYQLQESVVADQISLLSREWGFAEQLVLYLKVAELLSSGLQSAIDQIRAGK 925
E + YQ+QESVV DQIS LS++WG EQLVLY+K A+LL++ L A QI++GK
Sbjct: 851 PELCTSAVSLYQIQESVVVDQISQLSKDWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGK 910
Query: 926 LCLSSTVKQVVRRLNELYKASVVSCQGLSLRLQRFFLDKQRLLDRIHSITAERLIFSHAV 985
L S+ VKQVV+ LNE YK + C+ L+ +L RFF DKQR +D I+S+TAE+LI++ AV
Sbjct: 911 LSPSTAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVTAEKLIYNCAV 970
Query: 986 QMVQSAALDEMFQHREGCVPRYHKALLLLEGLQHMLSDQADIENVTKCKLCIERRLSAL 1044
+MVQSAALDEMFQ E V RYHKA LLLEGL +L D ADIENV K K IERRLSAL
Sbjct: 971 EMVQSAALDEMFQQTEDIVYRYHKAALLLEGLSRILQDPADIENVHKYKCSIERRLSAL 1029
>gi|150456432 unc-51-like kinase 3 [Homo sapiens]
Length = 472
Score = 199 bits (507), Expect = 9e-51
Identities = 115/312 (36%), Positives = 179/312 (57%), Gaps = 16/312 (5%)
Query: 3 PGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTL-LG 61
PG G G F + +G G +A V+K ++ VA+KC+ KK+L K+ L
Sbjct: 4 PGWGPPRLDG---FILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLL 60
Query: 62 KEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQ 121
EI+ILK ++H +IV L DFQ ++++YL+ME+C GGDL+ ++H R L E R+F+QQ
Sbjct: 61 TEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQ 120
Query: 122 IAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATL 181
+A A++ LH + I H DLKPQNILLS + +K+ADFGFA+++ L
Sbjct: 121 LASALQFLHERNISHLDLKPQNILLS-------SLEKPHLKLADFGFAQHMSPWDEKHVL 173
Query: 182 CGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVP 241
GSP+YMAPE++ + YD + DLWS+G I+Y+ L G+ PF + S +L N+ +
Sbjct: 174 RGSPLYMAPEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIEL 233
Query: 242 TIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLD-----ASPSVRKSPPVPVPSYP 296
+ S R LL LL+R+ R+ F +FF HP++D + S+ ++ + V +
Sbjct: 234 PLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPSGESLGRATALVVQAVK 293
Query: 297 SSGSGSSSSSSS 308
G S+++ S
Sbjct: 294 KDQEGDSAAALS 305
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 164 bits (416), Expect = 3e-40
Identities = 173/593 (29%), Positives = 252/593 (42%), Gaps = 113/593 (19%)
Query: 42 EVAVKCINKKNLAKSQTL-LGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDL 100
+VA+K +N++ L++S + + +EI ILK ++H +++ L+D E +YLV+E+ +GG+L
Sbjct: 59 KVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGEL 118
Query: 101 ADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIR 160
DYL L+ R F +QI A+ HS I HRDLKP+N+LL N+IR
Sbjct: 119 FDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLD-------EKNNIR 171
Query: 161 VKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDG-KADLWSIGTIVYQCLTGKA 219
IADFG A + + T CGSP Y PEVI + YDG +AD+WS G I++ L G
Sbjct: 172 --IADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGAL 229
Query: 220 PFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFL- 278
PF +LR EK K V +P + LL +++ + R+ ++ HP+
Sbjct: 230 PF---DDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYL 286
Query: 279 ----DASPSVRKSP--PVPVPSYPSSGSGSSSSSSSTSHLASPPSLGEMQQLQKTLASPA 332
+ P + +P V + S PS+G S +AS + ++L + L S
Sbjct: 287 GGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLES---MASLGCFRDRERLHRELRSEE 343
Query: 333 DT-AGFLHSSRDSGGSKDSSCDTDDFVMVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLVA 391
+ ++ + SC+ D PP + + V
Sbjct: 344 ENQEKMIYYLLLDRKERYPSCEDQDL--------------------PPRNDVDPPRKRVD 383
Query: 392 SAGLESHG-RTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQS 450
S L HG R P S + +G G PVPT+ R L+
Sbjct: 384 SPMLSRHGKRRPERKSMEVLSITDAGGGGS------------PVPTR--------RALEM 423
Query: 451 PTQFQTPRSSAIRRSG-STSPLGFARA-----SPSPPAHAEHGGVLARKMSLGGGRPYTP 504
Q RS + +G S+SPL R+ SP P A E + GGG +P
Sbjct: 424 AQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDE---------ARGGG---SP 471
Query: 505 SPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSAPEHSPRTSGLGCRLHSAPNLSDLH 564
+ + T+P R G Q +P PG P SPR+SG G LHS
Sbjct: 472 TSKTQTLPSRGPRGGGAGEQPPPPSARSTPLPG---PPGSPRSSG-GTPLHS-------- 519
Query: 565 VVRPKLPKPPTDPLGAVFSPPQASPPQPSHG---------LQSCRN-LRGSPK 607
L P P G +P PP P G L S RN GSP+
Sbjct: 520 ----PLHTPRASPTG---TPGTTPPPSPGGGVGGAAWRSRLNSIRNSFLGSPR 565
>gi|41872374 polo-like kinase 3 [Homo sapiens]
Length = 646
Score = 159 bits (401), Expect = 2e-38
Identities = 125/435 (28%), Positives = 199/435 (45%), Gaps = 38/435 (8%)
Query: 2 EPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAK--SQTL 59
+PGR T+ + + L+G G FA ++ E AVK I + +AK +
Sbjct: 48 DPGRLITDPRSGRTYLKGRLLGKGGFARCYEATDTETGSA-YAVKVIPQSRVAKPHQREK 106
Query: 60 LGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFL 119
+ EI++ ++L+H +IV E A+++Y+ +E C+ LA A TL E +R +L
Sbjct: 107 ILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYL 166
Query: 120 QQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQ-SNMMA 178
+QI ++ LH +GI+HRDLK N ++ ++ +K+ DFG A L+
Sbjct: 167 RQILSGLKYLHQRGILHRDLKLGNFFIT---------ENMELKVGDFGLAARLEPPEQRK 217
Query: 179 ATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKT 238
T+CG+P Y+APEV++ Q + +AD+WS+G ++Y L G PF+ + DL+ Y K
Sbjct: 218 KTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETA---DLKETYRCIKQ 274
Query: 239 LVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSP---PVPVPSY 295
+ T+P S P RQLL A+L+ + +DR D+ H F + + P V VP
Sbjct: 275 VHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTPDRLPISSCVTVPDL 334
Query: 296 PSSGSGSSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSS--RDSGGSKDSSCD 353
S + T SL ++ K A D L S R S G +D+ +
Sbjct: 335 TPPNPARSLFAKVTK------SLFGRKKKSKNHAQERDEVSGLVSGLMRTSVGHQDARPE 388
Query: 354 TDDFVMVPAQFPGDLVAEAPSAKPPPDSLMCSGS--------SLVASAGLESHGRTPSPS 405
P LV AP P +L SG + V + L + +
Sbjct: 389 AP---AASGPAPVSLVETAPEDSSPRGTLASSGDGFEEGLTVATVVESALCALRNCIAFM 445
Query: 406 PPCSSSPSPSGRAGP 420
PP +P+P + P
Sbjct: 446 PPAEQNPAPLAQPEP 460
>gi|121114283 polo-like kinase 4 [Homo sapiens]
Length = 970
Score = 155 bits (393), Expect = 1e-37
Identities = 104/306 (33%), Positives = 167/306 (54%), Gaps = 25/306 (8%)
Query: 15 EFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTL--LGKEIKILKELKH 72
+F +L+G G+FA V++ LEVA+K I+KK + K+ + + E+KI +LKH
Sbjct: 11 DFKVGNLLGKGSFAGVYRAESIHT-GLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKH 69
Query: 73 ENIVALYDFQEMANSVYLVMEYCNGGDLADYL-HAMRTLSEDTIRLFLQQIAGAMRLLHS 131
+I+ LY++ E +N VYLV+E C+ G++ YL + ++ SE+ R F+ QI M LHS
Sbjct: 70 PSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHS 129
Query: 132 KGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQS-NMMAATLCGSPMYMAP 190
GI+HRDL N+LL+ ++ +KIADFG A L+ + TLCG+P Y++P
Sbjct: 130 HGILHRDLTLSNLLLTR---------NMNIKIADFGLATQLKMPHEKHYTLCGTPNYISP 180
Query: 191 EVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPT--IPRETS 248
E+ + ++D+WS+G + Y L G+ PF + ++ NK ++ +P S
Sbjct: 181 EIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTL-----NKVVLADYEMPSFLS 235
Query: 249 APLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSG----SGSSS 304
+ L+ LL+RN DR+ HPF+ + S + V SG S + +
Sbjct: 236 IEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDSGHATISTAIT 295
Query: 305 SSSSTS 310
+SSSTS
Sbjct: 296 ASSSTS 301
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 153 bits (387), Expect = 7e-37
Identities = 127/442 (28%), Positives = 204/442 (46%), Gaps = 37/442 (8%)
Query: 20 DLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALY 79
+++G GAF+ VF + R L A+KCI KK+ A + L EI +LK++KHENIV L
Sbjct: 27 EVLGSGAFSEVFLVKQRLTGKL-FALKCI-KKSPAFRDSSLENEIAVLKKIKHENIVTLE 84
Query: 80 DFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDL 139
D E YLVM+ +GG+L D + +E L +QQ+ A++ LH GI+HRDL
Sbjct: 85 DIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDL 144
Query: 140 KPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYD 199
KP+N+L P + ++ I DFG ++ Q+ +M +T CG+P Y+APEV+ + Y
Sbjct: 145 KPENLLYLTP------EENSKIMITDFGLSKMEQNGIM-STACGTPGYVAPEVLAQKPYS 197
Query: 200 GKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNK----TLVPTIPRETSAPLRQLL 255
D WSIG I Y L G PF + L +EK K + S + +
Sbjct: 198 KAVDCWSIGVITYILLCGYPPFYEETESKL---FEKIKEGYYEFESPFWDDISESAKDFI 254
Query: 256 LALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGSGSSSSSSSTSHLASP 315
LL+++ +R ++ HP++D + ++ + PS + + S +
Sbjct: 255 CHLLEKDPNERYTCEKALSHPWIDGNTALHRD---IYPSVSLQIQKNFAKSKWRQAFNAA 311
Query: 316 PSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMVPAQFPGDLVA----- 370
+ M++L L SP + ++ S+ S + + + A VA
Sbjct: 312 AVVHHMRKLHMNLHSPGVRPEVENRPPETQASETSRPSSPEITITEAPVLDHSVALPALT 371
Query: 371 -------EAPSAKPPPDSLMC--SGSSLVASAGLESHGRTPSPSP-PCSSSPSPSGRAGP 420
P+A P SL C +GS ++S+ + H + + P C SS G G
Sbjct: 372 QLPCQHGRRPTA-PGGRSLNCLVNGSLHISSSLVPMHQGSLAAGPCGCCSSCLNIGSKG- 429
Query: 421 FSSSRCGASVPIPVPTQVQNYQ 442
SS C + + QN++
Sbjct: 430 -KSSYCSEPTLLKKANKKQNFK 450
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 152 bits (385), Expect = 1e-36
Identities = 94/274 (34%), Positives = 148/274 (54%), Gaps = 16/274 (5%)
Query: 20 DLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTL-LGKEIKILKELKHENIVAL 78
++IG G+F V+KGR + + VA+K I K ++ + L +EI+I++ L+H NIV +
Sbjct: 8 EMIGEGSFGRVYKGRRKYSAQV-VALKFIPKLGRSEKELRNLQREIEIMRGLRHPNIVHM 66
Query: 79 YDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRD 138
D E V +V +Y G +L L L ED ++ Q+ A+ LHS I+HRD
Sbjct: 67 LDSFETDKEVVVVTDYAEG-ELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRILHRD 125
Query: 139 LKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT-LCGSPMYMAPEVIMSQH 197
+KPQNILL+ G +K+ DFGFAR + +N M T + G+P+YM+PE++ +
Sbjct: 126 MKPQNILLAKGGG---------IKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERP 176
Query: 198 YDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLA 257
YD ADLWS+G I+Y+ G PF A+S L K+ P+ S + L
Sbjct: 177 YDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRWPS---TISPCFKNFLQG 233
Query: 258 LLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVP 291
LL ++ + R+ + + +HPF+ ++ P P
Sbjct: 234 LLTKDPRQRLSWPDLLYHPFIAGHVTIITEPAGP 267
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 152 bits (383), Expect = 2e-36
Identities = 95/280 (33%), Positives = 149/280 (53%), Gaps = 20/280 (7%)
Query: 22 IGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQT-LLGKEIKILKELKHENIVALYD 80
+G G FAVV RH + +VAVK I+K L T L +E++ +K ++H NIV LY+
Sbjct: 22 LGRGHFAVVKLARHVFTGE-KVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYE 80
Query: 81 FQEMANSVYLVMEYCNGGDLADYLHAMRT-LSEDTIRLFLQQIAGAMRLLHSKGIIHRDL 139
+ +YL++E +GGD+ DY+ L+ED + + QI A+ H ++HRDL
Sbjct: 81 VIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDL 140
Query: 140 KPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYD 199
KP+N++ G VK+ DFGF+ Q T CGS Y APE+++ YD
Sbjct: 141 KPENVVFFEKQG--------LVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYD 192
Query: 200 GKA-DLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLAL 258
A D+WS+G I++ + G+ PFQ ++ + K T+P S + L+ +
Sbjct: 193 APAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKY---TVPSHVSKECKDLITRM 249
Query: 259 LQRNHKDRMDFDEFFHHPFL---DASPSVRKSPPVPVPSY 295
LQR+ K R +E +HP+L D SP+ + + +P+ SY
Sbjct: 250 LQRDPKRRASLEEIENHPWLQGVDPSPATKYN--IPLVSY 287
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 152 bits (383), Expect = 2e-36
Identities = 95/280 (33%), Positives = 149/280 (53%), Gaps = 20/280 (7%)
Query: 22 IGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQT-LLGKEIKILKELKHENIVALYD 80
+G G FAVV RH + +VAVK I+K L T L +E++ +K ++H NIV LY+
Sbjct: 22 LGRGHFAVVKLARHVFTGE-KVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYE 80
Query: 81 FQEMANSVYLVMEYCNGGDLADYLHAMRT-LSEDTIRLFLQQIAGAMRLLHSKGIIHRDL 139
+ +YL++E +GGD+ DY+ L+ED + + QI A+ H ++HRDL
Sbjct: 81 VIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDL 140
Query: 140 KPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYD 199
KP+N++ G VK+ DFGF+ Q T CGS Y APE+++ YD
Sbjct: 141 KPENVVFFEKQG--------LVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYD 192
Query: 200 GKA-DLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLAL 258
A D+WS+G I++ + G+ PFQ ++ + K T+P S + L+ +
Sbjct: 193 APAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKY---TVPSHVSKECKDLITRM 249
Query: 259 LQRNHKDRMDFDEFFHHPFL---DASPSVRKSPPVPVPSY 295
LQR+ K R +E +HP+L D SP+ + + +P+ SY
Sbjct: 250 LQRDPKRRASLEEIENHPWLQGVDPSPATKYN--IPLVSY 287
>gi|23943882 serine/threonine kinase 33 [Homo sapiens]
Length = 514
Score = 151 bits (381), Expect = 4e-36
Identities = 80/212 (37%), Positives = 124/212 (58%), Gaps = 4/212 (1%)
Query: 21 LIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQT-LLGKEIKILKELKHENIVALY 79
++G G+F +V + +E + + A+K +NK+ S LL +E+ ILK +KHE+I+ L
Sbjct: 121 ILGKGSFGIVIEATDKET-ETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHIIHLE 179
Query: 80 DFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDL 139
E +YLVME C G+L + L SE+ R +Q +A A+ LH+ I+HRDL
Sbjct: 180 QVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDL 239
Query: 140 KPQNILLSNPAGRRANPNSIRVKIADFGFA--RYLQSNMMAATLCGSPMYMAPEVIMSQH 197
K +NI++ + N ++ +K+ DFG A + +S M CG+P+YMAPEVI +
Sbjct: 240 KLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVISAHD 299
Query: 198 YDGKADLWSIGTIVYQCLTGKAPFQASSPQDL 229
Y + D+WSIG ++Y L G+ PF ASS + L
Sbjct: 300 YSQQCDIWSIGVVMYMLLRGEPPFLASSEEKL 331
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 149 bits (377), Expect = 1e-35
Identities = 96/278 (34%), Positives = 145/278 (52%), Gaps = 20/278 (7%)
Query: 11 VGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTL-LGKEIKILKE 69
+G +E R IG G FAVV + H +VA+K I+K L + + +E++I+K
Sbjct: 5 IGYYEIDRT--IGKGNFAVVKRATHLVTK-AKVAIKIIDKTQLDEENLKKIFREVQIMKM 61
Query: 70 LKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLL 129
L H +I+ LY E +YLV EY +GG++ D+L A ++E R +QI A+
Sbjct: 62 LCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFC 121
Query: 130 HSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMA 189
H + I+HRDLK +N+LL AN N +KIADFGF+ + T CGSP Y A
Sbjct: 122 HCRNIVHRDLKAENLLLD------ANLN---IKIADFGFSNLFTPGQLLKTWCGSPPYAA 172
Query: 190 PEVIMSQHYDG-KADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETS 248
PE+ + YDG K D+WS+G ++Y + G PF S+ Q+LR K +P S
Sbjct: 173 PELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFF---MS 229
Query: 249 APLRQLLLALLQRNHKDRMDFDEFFHHPFL---DASPS 283
L+ +L + R+ ++ H ++ DA P+
Sbjct: 230 TECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPN 267
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 149 bits (377), Expect = 1e-35
Identities = 90/239 (37%), Positives = 130/239 (54%), Gaps = 12/239 (5%)
Query: 22 IGHGAFAVVFKGRHREKHDLEVAVKCINKKNL-AKSQTLLGKEIKILKELKHENIVALYD 80
+G G FAVV GRHR EVA+K I+K L A + + +E++I+K L H +I+ LY
Sbjct: 26 LGKGNFAVVKLGRHRITKT-EVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQ 84
Query: 81 FQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLK 140
E + +YLV EY G++ DYL L+E R QI A+ H + I+HRDLK
Sbjct: 85 VMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLK 144
Query: 141 PQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDG 200
+N+LL N++ +KIADFGF + +S + AT CGSP Y APEV Q Y+G
Sbjct: 145 AENLLLD---------NNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEG 195
Query: 201 -KADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLAL 258
+ D+WS+G ++Y + G PF + LR + + +P E L + +L L
Sbjct: 196 PQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVL 254
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 149 bits (377), Expect = 1e-35
Identities = 174/671 (25%), Positives = 269/671 (40%), Gaps = 97/671 (14%)
Query: 11 VGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTL-LGKEIKILKE 69
VG + R IG G FA V RH EVA+K I+K L S L +E++I+K
Sbjct: 56 VGNYRLLRT--IGKGNFAKVKLARHILT-GREVAIKIIDKTQLNPSSLQKLFREVRIMKG 112
Query: 70 LKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLL 129
L H NIV L++ E ++YLVMEY + G++ DYL + + E R +QI A+
Sbjct: 113 LNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYC 172
Query: 130 HSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMA 189
H K I+HRDLK +N+LL A +KIADFGF+ T CGSP Y A
Sbjct: 173 HQKNIVHRDLKAENLLLDAEA---------NIKIADFGFSNEFTLGSKLDTFCGSPPYAA 223
Query: 190 PEVIMSQHYDG-KADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETS 248
PE+ + YDG + D+WS+G I+Y ++G PF + ++LR + K VP S
Sbjct: 224 PELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFY---MS 280
Query: 249 APLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVP--------------- 293
+L L N R ++ +++ + P P
Sbjct: 281 TDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVG 340
Query: 294 -SYPSSGSGSSSSSSSTSHLASPPSL-----------GEMQQLQKTLASPADTAGFLHSS 341
Y S +S + + + L G + +P+DT SS
Sbjct: 341 MGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSS 400
Query: 342 RDSGGSKDSSCDTDDFVMVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLV----------- 390
+ + SK + + + D +P+ P S +G + +
Sbjct: 401 KGTSHSKGQRSSSSTYHR--QRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKAS 458
Query: 391 -ASAGLESHGRTPSPSPPCSSSPSPSGRAGP---FSSSRCGASVPIPVPTQVQNYQRIER 446
++AG S G PS SP SS+ +P+ P S+ ++P + T+ Y ER
Sbjct: 459 CSTAGSGSRGLPPS-SPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTER 517
Query: 447 -NLQSPTQFQTPR--SSAIRRSGSTSPLGFARASPSPP----------AHAEHGGVLARK 493
+ P+ + SS R SP + A PS HGG + +
Sbjct: 518 PGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDR 577
Query: 494 MSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSAPEHSPRTSGLGCR 553
+ GGG G + P S T + + A + GR PRP ++ + TS L R
Sbjct: 578 RAGGGGG--------GGVQNGPPASPTLAHEAAPLPAGR-PRPTTNL--FTKLTSKLTRR 626
Query: 554 LHSAPNLSDLHVVRPKLPKPPTDPLGAVFSPPQASPPQPSHGLQSCRNLRGSPKLPDFLQ 613
+ P+ + ++ + S PQ S + L+ +LR + ++
Sbjct: 627 VTLDPS-----------KRQNSNRCVSGASLPQGSKIRSQTNLRESGDLRSQVAIYLGIK 675
Query: 614 RNPLPPILGSP 624
R P P SP
Sbjct: 676 RKPPPGCSDSP 686
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 149 bits (376), Expect = 1e-35
Identities = 148/579 (25%), Positives = 225/579 (38%), Gaps = 62/579 (10%)
Query: 22 IGHGAFAVVFKGRHREKHDLEVAVKCINKKNL-AKSQTLLGKEIKILKELKHENIVALYD 80
IG G FA V RH EVAVK I+K L + S L +E++I+K L H NIV L++
Sbjct: 59 IGKGNFAKVKLARHILTGK-EVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
Query: 81 FQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLK 140
E ++YLVMEY +GG++ DYL A + E R +QI A++ H K I+HRDLK
Sbjct: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
Query: 141 PQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDG 200
+N+LL + +KIADFGF+ T CGSP Y APE+ + YDG
Sbjct: 178 AENLLLD---------ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 201 -KADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALL 259
+ D+WS+G I+Y ++G PF + ++LR + K IP S LL L
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY---RIPFYMSTDCENLLKKFL 285
Query: 260 QRNHKDRMDFDEFFHHPFLDASPSVRKSPPV--PVPSYPSSGSGSSSSSSSTSHLASPPS 317
N R ++ +++ + P P+P Y S + S
Sbjct: 286 ILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDS 345
Query: 318 LGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMVPAQFPGDLVAEAPSAKP 377
L Q+ + +A+ G K S + D + KP
Sbjct: 346 L-VGQRYNEVMATYLLL-----------GYKSSELEGDTITL----------------KP 377
Query: 378 PPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQ 437
P + + + S+ PSPS S S + + FS G ++P
Sbjct: 378 RPSADLTNSSA-------------PSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYS 424
Query: 438 VQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPL-GFARASPSPPAHAEHGGVLARKMSL 496
+ N + ++ R ++ SPL G R +P VL+ +
Sbjct: 425 KKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPST--NSVLSTSTNR 482
Query: 497 GGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSAPEHSPRTSGLGCRLHS 556
P +G + G P S ++ P ++ +
Sbjct: 483 SRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNK 542
Query: 557 APNLSDLHVVRPKLPKPPTDPLGAVFSPPQASPPQPSHG 595
A L ++P+P T P + P A S G
Sbjct: 543 ASGLPPTE-SNCEVPRPSTAPQRVPVASPSAHNISSSGG 580
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 149 bits (375), Expect = 2e-35
Identities = 159/579 (27%), Positives = 231/579 (39%), Gaps = 63/579 (10%)
Query: 22 IGHGAFAVVFKGRHREKHDLEVAVKCINKKNL-AKSQTLLGKEIKILKELKHENIVALYD 80
IG G FA V RH EVAVK I+K L + S L +E++I+K L H NIV L++
Sbjct: 26 IGKGNFAKVKLARHILTGK-EVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 84
Query: 81 FQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLK 140
E ++YLVMEY +GG++ DYL A + E R +QI A++ H K I+HRDLK
Sbjct: 85 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 144
Query: 141 PQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDG 200
+N+LL + +KIADFGF+ T CGSP Y APE+ + YDG
Sbjct: 145 AENLLLD---------ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 195
Query: 201 -KADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALL 259
+ D+WS+G I+Y ++G PF + ++LR + K IP S LL L
Sbjct: 196 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY---RIPFYMSTDCENLLKKFL 252
Query: 260 QRNHKDRMDFDEFFHHPFLDASPSVRKSPPV--PVPSYPSSGSGSSSSSSSTSHLASPPS 317
N R ++ +++ + P P+P Y S + S
Sbjct: 253 ILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDS 312
Query: 318 LGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMVPAQFPGDLVAEAPSAKP 377
L + Q + + G+ S + + D A P V + SA P
Sbjct: 313 L--VGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANP 370
Query: 378 PPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPI-PVPT 436
+ ++ S+ + + + P +G +SS A VP P+P
Sbjct: 371 KQRRFSDQAGPAIPTS--NSYSKKTQSNNAENKRPEEDRESGRKASST--AKVPASPLP- 425
Query: 437 QVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSPPAHAEHGGVLARKMSL 496
+ER +PT S SPL RAS A ++G +++
Sbjct: 426 ------GLERKKTTPTPSTNSVLSTSTNRSRNSPL-LERASLG-QASIQNG---KDSLTM 474
Query: 497 GGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSAPEHSPRTSGLGCRLHS 556
G R T S RP R + SA H + SGL
Sbjct: 475 PGSRASTASASAAVSAARP----------------RQHQKSMSASVHPNKASGL------ 512
Query: 557 APNLSDLHVVRPKLPKPPTDPLGAVFSPPQASPPQPSHG 595
P S+ V P+P T P + P A S G
Sbjct: 513 PPTESNCEV-----PRPSTAPQRVPVASPSAHNISSSGG 546
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 148 bits (374), Expect = 2e-35
Identities = 152/531 (28%), Positives = 219/531 (41%), Gaps = 70/531 (13%)
Query: 4 GRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTL-LGK 62
G + VG + + +G G +V G H +VA+K +N++ L++S + + +
Sbjct: 9 GAQHAQYVGPYRLEKT--LGKGQTGLVKLGVHCVTCQ-KVAIKIVNREKLSESVLMKVER 65
Query: 63 EIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQI 122
EI ILK ++H +++ L+D E +YLV+E+ +GG+L DYL L+ R F +QI
Sbjct: 66 EIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQI 125
Query: 123 AGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLC 182
A+ HS I HRDLKP+N+LL N+IR IADFG A + + T C
Sbjct: 126 ISALDFCHSHSICHRDLKPENLLLD-------EKNNIR--IADFGMASLQVGDSLLETSC 176
Query: 183 GSPMYMAPEVIMSQHYDG-KADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVP 241
GSP Y PEVI + YDG KAD+WS G I++ L G PF +LR EK K V
Sbjct: 177 GSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPF---DDDNLRQLLEKVKRGVF 233
Query: 242 TIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGSG 301
+P + LL +++ + R+ + H + + P P+P S
Sbjct: 234 HMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKN-EPEPEQPIPRKVQIRSL 292
Query: 302 SSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMVP 361
S L S SLG + K L L S ++ D P
Sbjct: 293 PSLEDIDPDVLDSMHSLGCFRDRNKLLQD-------LLSEEENQEKMIYFLLLDRKERYP 345
Query: 362 AQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGPF 421
+Q DL PP + + V S L HG+ P ++
Sbjct: 346 SQEDEDL---------PPRNEIDPPRKRVDSPMLNRHGKR-----------RPERKSMEV 385
Query: 422 SSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSG-STSPLGFARASPSP 480
S G S PVP + R ++ Q RS + SG STSPL R +P P
Sbjct: 386 LSVTDGGS---PVPAR--------RAIEMAQHGQRSRSISGASSGLSTSPLSSPRVTPHP 434
Query: 481 PAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGG 531
G P V T E P + P+P + GG
Sbjct: 435 SPR-------------GSPLPTPKGTPVHTPKESPAGTPNPTPPSSPSVGG 472
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 148 bits (373), Expect = 3e-35
Identities = 99/278 (35%), Positives = 141/278 (50%), Gaps = 17/278 (6%)
Query: 22 IGHGAFAVVFKGRHREKHDLEVAVKCINKKNL-AKSQTLLGKEIKILKELKHENIVALYD 80
IG G FA V RH EVAVK I+K L + S L +E++I+K L H NIV L++
Sbjct: 59 IGKGNFAKVKLARHILTGK-EVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
Query: 81 FQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLK 140
E ++YLVMEY +GG++ DYL A + E R +QI A++ H K I+HRDLK
Sbjct: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
Query: 141 PQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDG 200
+N+LL + +KIADFGF+ T CGSP Y APE+ + YDG
Sbjct: 178 AENLLLD---------ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 201 -KADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALL 259
+ D+WS+G I+Y ++G PF + ++LR + K IP S LL L
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY---RIPFYMSTDCENLLKKFL 285
Query: 260 QRNHKDRMDFDEFFHHPFLDASPSVRKSPPV--PVPSY 295
N R ++ +++ + P P+P Y
Sbjct: 286 ILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDY 323
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 148 bits (373), Expect = 3e-35
Identities = 99/278 (35%), Positives = 141/278 (50%), Gaps = 17/278 (6%)
Query: 22 IGHGAFAVVFKGRHREKHDLEVAVKCINKKNL-AKSQTLLGKEIKILKELKHENIVALYD 80
IG G FA V RH EVAVK I+K L + S L +E++I+K L H NIV L++
Sbjct: 59 IGKGNFAKVKLARHILTGK-EVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
Query: 81 FQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLK 140
E ++YLVMEY +GG++ DYL A + E R +QI A++ H K I+HRDLK
Sbjct: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
Query: 141 PQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDG 200
+N+LL + +KIADFGF+ T CGSP Y APE+ + YDG
Sbjct: 178 AENLLLD---------ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 201 -KADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALL 259
+ D+WS+G I+Y ++G PF + ++LR + K IP S LL L
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY---RIPFYMSTDCENLLKKFL 285
Query: 260 QRNHKDRMDFDEFFHHPFLDASPSVRKSPPV--PVPSY 295
N R ++ +++ + P P+P Y
Sbjct: 286 ILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDY 323
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 148 bits (373), Expect = 3e-35
Identities = 99/278 (35%), Positives = 141/278 (50%), Gaps = 17/278 (6%)
Query: 22 IGHGAFAVVFKGRHREKHDLEVAVKCINKKNL-AKSQTLLGKEIKILKELKHENIVALYD 80
IG G FA V RH EVAVK I+K L + S L +E++I+K L H NIV L++
Sbjct: 59 IGKGNFAKVKLARHILTGK-EVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 117
Query: 81 FQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLK 140
E ++YLVMEY +GG++ DYL A + E R +QI A++ H K I+HRDLK
Sbjct: 118 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 177
Query: 141 PQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDG 200
+N+LL + +KIADFGF+ T CGSP Y APE+ + YDG
Sbjct: 178 AENLLLD---------ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 201 -KADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALL 259
+ D+WS+G I+Y ++G PF + ++LR + K IP S LL L
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY---RIPFYMSTDCENLLKKFL 285
Query: 260 QRNHKDRMDFDEFFHHPFLDASPSVRKSPPV--PVPSY 295
N R ++ +++ + P P+P Y
Sbjct: 286 ILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDY 323
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 148 bits (373), Expect = 3e-35
Identities = 98/274 (35%), Positives = 138/274 (50%), Gaps = 15/274 (5%)
Query: 22 IGHGAFAVVFKGRHREKHDLEVAVKCINKKNL-AKSQTLLGKEIKILKELKHENIVALYD 80
IG G FA V RH EVAVK I+K L S L +E++I+K L H NIV L++
Sbjct: 66 IGKGNFAKVKLARH-VLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 124
Query: 81 FQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLK 140
E ++YLVMEY +GG++ DYL A + E R +QI A++ H K I+HRDLK
Sbjct: 125 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLK 184
Query: 141 PQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDG 200
+N+LL + +KIADFGF+ T CGSP Y APE+ + YDG
Sbjct: 185 AENLLLD---------GDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDG 235
Query: 201 -KADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALL 259
+ D+WS+G I+Y ++G PF + ++LR + K IP S LL LL
Sbjct: 236 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKY---RIPFYMSTDCENLLKKLL 292
Query: 260 QRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVP 293
N R ++ +++ + P P
Sbjct: 293 VLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEP 326
>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
Length = 436
Score = 145 bits (367), Expect = 1e-34
Identities = 94/293 (32%), Positives = 150/293 (51%), Gaps = 28/293 (9%)
Query: 22 IGHGAFAVVFKGRHREKHDLEVAVKCINKKNL-AKSQTLLGKEIKILKELKHENIVALYD 80
IG G F+ V G H + +VA+K ++K L K+Q LL +EI +++L H NI+ LY+
Sbjct: 80 IGSGNFSQVKLGIHSLTKE-KVAIKILDKTKLDQKTQRLLSREISSMEKLHHPNIIRLYE 138
Query: 81 FQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLK 140
E + ++LVMEY GG+L + LSE +L QI A++ +H IIHRDLK
Sbjct: 139 VVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHENQIIHRDLK 198
Query: 141 PQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDG 200
+N+ + ++ VK+ DFGF+ + M T CGSP Y APE+ +HY G
Sbjct: 199 AENVFYT---------SNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDEHYIG 249
Query: 201 -KADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVP---TIPRETSAPLRQLLL 256
D+W++G ++Y +TG PF+A + L+ K+++ ++P S P +L+
Sbjct: 250 IYVDIWALGVLLYFMVTGTMPFRAETVAKLK------KSILEGTYSVPPHVSEPCHRLIR 303
Query: 257 ALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGSGSSSSSSST 309
+LQ+ +R D + ++ + P P P P S +ST
Sbjct: 304 GVLQQIPTERYGIDCIMNDEWM-------QGVPYPTPLEPFQLDPKHLSETST 349
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 144 bits (364), Expect = 3e-34
Identities = 91/279 (32%), Positives = 143/279 (51%), Gaps = 18/279 (6%)
Query: 14 FEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHE 73
FEF K+ +G GAF+ V + L AVKCI KK L ++ + EI +L+++KHE
Sbjct: 23 FEF--KETLGTGAFSEVVLAEEKATGKL-FAVKCIPKKALKGKESSIENEIAVLRKIKHE 79
Query: 74 NIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKG 133
NIVAL D E N +YLVM+ +GG+L D + +E ++Q+ A+ LH G
Sbjct: 80 NIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMG 139
Query: 134 IIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVI 193
I+HRDLKP+N+L + ++ I+DFG ++ + +T CG+P Y+APEV+
Sbjct: 140 IVHRDLKPENLLY------YSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVL 193
Query: 194 MSQHYDGKADLWSIGTIVYQCLTGKAPFQASS-----PQDLRLFYEKNKTLVPTIPRETS 248
+ Y D WSIG I Y L G PF + Q L+ YE + I S
Sbjct: 194 AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDI----S 249
Query: 249 APLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKS 287
+ + L++++ R ++ HP++ ++ K+
Sbjct: 250 DSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKN 288
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 144 bits (364), Expect = 3e-34
Identities = 91/279 (32%), Positives = 143/279 (51%), Gaps = 18/279 (6%)
Query: 14 FEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHE 73
FEF K+ +G GAF+ V + L AVKCI KK L ++ + EI +L+++KHE
Sbjct: 23 FEF--KETLGTGAFSEVVLAEEKATGKL-FAVKCIPKKALKGKESSIENEIAVLRKIKHE 79
Query: 74 NIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKG 133
NIVAL D E N +YLVM+ +GG+L D + +E ++Q+ A+ LH G
Sbjct: 80 NIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMG 139
Query: 134 IIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVI 193
I+HRDLKP+N+L + ++ I+DFG ++ + +T CG+P Y+APEV+
Sbjct: 140 IVHRDLKPENLLY------YSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVL 193
Query: 194 MSQHYDGKADLWSIGTIVYQCLTGKAPFQASS-----PQDLRLFYEKNKTLVPTIPRETS 248
+ Y D WSIG I Y L G PF + Q L+ YE + I S
Sbjct: 194 AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDI----S 249
Query: 249 APLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKS 287
+ + L++++ R ++ HP++ ++ K+
Sbjct: 250 DSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKN 288
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 144 bits (364), Expect = 3e-34
Identities = 86/222 (38%), Positives = 123/222 (55%), Gaps = 12/222 (5%)
Query: 22 IGHGAFAVVFKGRHREKHDLEVAVKCINKKNL-AKSQTLLGKEIKILKELKHENIVALYD 80
IG G FA V RH EVA+K I+K L S L +E++I+K L H NIV L++
Sbjct: 62 IGKGNFAKVKLARHILT-GREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
Query: 81 FQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLK 140
E ++YL+MEY +GG++ DYL A + E R +QI A++ H K I+HRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
Query: 141 PQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDG 200
+N+LL + +KIADFGF+ T CGSP Y APE+ + YDG
Sbjct: 181 AENLLLD---------ADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
Query: 201 -KADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVP 241
+ D+WS+G I+Y ++G PF + ++LR + K +P
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP 273
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 144 bits (364), Expect = 3e-34
Identities = 86/222 (38%), Positives = 123/222 (55%), Gaps = 12/222 (5%)
Query: 22 IGHGAFAVVFKGRHREKHDLEVAVKCINKKNL-AKSQTLLGKEIKILKELKHENIVALYD 80
IG G FA V RH EVA+K I+K L S L +E++I+K L H NIV L++
Sbjct: 62 IGKGNFAKVKLARHILT-GREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
Query: 81 FQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLK 140
E ++YL+MEY +GG++ DYL A + E R +QI A++ H K I+HRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
Query: 141 PQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDG 200
+N+LL + +KIADFGF+ T CGSP Y APE+ + YDG
Sbjct: 181 AENLLLD---------ADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
Query: 201 -KADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVP 241
+ D+WS+G I+Y ++G PF + ++LR + K +P
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP 273
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 144 bits (364), Expect = 3e-34
Identities = 86/222 (38%), Positives = 123/222 (55%), Gaps = 12/222 (5%)
Query: 22 IGHGAFAVVFKGRHREKHDLEVAVKCINKKNL-AKSQTLLGKEIKILKELKHENIVALYD 80
IG G FA V RH EVA+K I+K L S L +E++I+K L H NIV L++
Sbjct: 62 IGKGNFAKVKLARHILT-GREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
Query: 81 FQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLK 140
E ++YL+MEY +GG++ DYL A + E R +QI A++ H K I+HRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
Query: 141 PQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDG 200
+N+LL + +KIADFGF+ T CGSP Y APE+ + YDG
Sbjct: 181 AENLLLD---------ADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
Query: 201 -KADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVP 241
+ D+WS+G I+Y ++G PF + ++LR + K +P
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP 273
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 144 bits (364), Expect = 3e-34
Identities = 86/222 (38%), Positives = 123/222 (55%), Gaps = 12/222 (5%)
Query: 22 IGHGAFAVVFKGRHREKHDLEVAVKCINKKNL-AKSQTLLGKEIKILKELKHENIVALYD 80
IG G FA V RH EVA+K I+K L S L +E++I+K L H NIV L++
Sbjct: 62 IGKGNFAKVKLARHILT-GREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 120
Query: 81 FQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLK 140
E ++YL+MEY +GG++ DYL A + E R +QI A++ H K I+HRDLK
Sbjct: 121 VIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLK 180
Query: 141 PQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDG 200
+N+LL + +KIADFGF+ T CGSP Y APE+ + YDG
Sbjct: 181 AENLLLD---------ADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231
Query: 201 -KADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVP 241
+ D+WS+G I+Y ++G PF + ++LR + K +P
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP 273
>gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 144 bits (362), Expect = 6e-34
Identities = 89/272 (32%), Positives = 145/272 (53%), Gaps = 18/272 (6%)
Query: 14 FEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKS--QTLLGKEIKILKELK 71
FE R +G G F V+ R ++ + +A+K + K L K+ + L +E++I L+
Sbjct: 133 FEIGRP--LGKGKFGNVYLAREKQSKFI-LALKVLFKAQLEKAGVEHQLRREVEIQSHLR 189
Query: 72 HENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHS 131
H NI+ LY + A VYL++EY G + L + E ++ ++A A+ HS
Sbjct: 190 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS 249
Query: 132 KGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPE 191
K +IHRD+KP+N+LL + +KIADFG++ + S+ TLCG+ Y+ PE
Sbjct: 250 KRVIHRDIKPENLLLGSAG---------ELKIADFGWSVHAPSS-RRTTLCGTLDYLPPE 299
Query: 192 VIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPL 251
+I + +D K DLWS+G + Y+ L GK PF+A++ Q+ Y++ + T P +
Sbjct: 300 MIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQET---YKRISRVEFTFPDFVTEGA 356
Query: 252 RQLLLALLQRNHKDRMDFDEFFHHPFLDASPS 283
R L+ LL+ N R E HP++ A+ S
Sbjct: 357 RDLISRLLKHNPSQRPMLREVLEHPWITANSS 388
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,146,719
Number of Sequences: 37866
Number of extensions: 3101308
Number of successful extensions: 30326
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 754
Number of HSP's successfully gapped in prelim test: 1372
Number of HSP's that attempted gapping in prelim test: 17681
Number of HSP's gapped (non-prelim): 9016
length of query: 1050
length of database: 18,247,518
effective HSP length: 113
effective length of query: 937
effective length of database: 13,968,660
effective search space: 13088634420
effective search space used: 13088634420
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.