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Search of human proteins with 4507185
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4507185 sepiapterin reductase [Homo sapiens]
(261 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4507185 sepiapterin reductase [Homo sapiens] 509 e-145
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens] 54 2e-07
gi|40254992 carbonic reductase 4 [Homo sapiens] 51 1e-06
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ... 50 3e-06
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap... 49 4e-06
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi... 47 1e-05
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ... 46 3e-05
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens] 45 8e-05
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens] 44 1e-04
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform... 44 1e-04
gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo... 44 1e-04
gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo ... 44 1e-04
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 43 2e-04
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ... 42 5e-04
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 41 0.001
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 41 0.001
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens] 40 0.002
gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Ho... 40 0.003
gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Ho... 40 0.003
gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens] 39 0.005
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 39 0.005
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ... 37 0.023
gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [... 34 0.11
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens] 34 0.15
gi|4502601 carbonyl reductase 3 [Homo sapiens] 33 0.33
gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo... 32 0.43
gi|223646115 short chain dehydrogenase/reductase family 16C, mem... 32 0.56
gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 32 0.56
gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 32 0.56
gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 32 0.56
>gi|4507185 sepiapterin reductase [Homo sapiens]
Length = 261
Score = 509 bits (1312), Expect = e-145
Identities = 261/261 (100%), Positives = 261/261 (100%)
Query: 1 MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSG 60
MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSG
Sbjct: 1 MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSG 60
Query: 61 LRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQV 120
LRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQV
Sbjct: 61 LRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQV 120
Query: 121 NNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDML 180
NNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDML
Sbjct: 121 NNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDML 180
Query: 181 FQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQK 240
FQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQK
Sbjct: 181 FQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQK 240
Query: 241 LLSLLEKDEFKSGAHVDFYDK 261
LLSLLEKDEFKSGAHVDFYDK
Sbjct: 241 LLSLLEKDEFKSGAHVDFYDK 261
>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
Length = 244
Score = 53.5 bits (127), Expect = 2e-07
Identities = 63/240 (26%), Positives = 112/240 (46%), Gaps = 23/240 (9%)
Query: 6 GRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVR 65
GR V L+TGA +G GR + +L + G+ +V +R L L E G+ V
Sbjct: 7 GRRV-LVTGAGKGIGRGT---VQALHATGARVVAVSRTQADLDSLVREC----PGIEPVC 58
Query: 66 VPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWA 125
V DLG ++ LG++ + LL+NNA + + F++++ + +
Sbjct: 59 V--DLGDWEATERALGSVGPVD--------LLVNNAAVA--LLQPFLEVTKEA-FDRSFE 105
Query: 126 LNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLA 185
+NL +++ ++ V + + G+ +VN+SS C+ + ++YC+ K A DML +V+A
Sbjct: 106 VNLRAVIQVSQIVARGLI-ARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMA 164
Query: 186 LEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLL 245
LE ++ A P M + + T DP K + GK + + +L LL
Sbjct: 165 LELGPHKIRVNAVNP-TVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLL 223
>gi|40254992 carbonic reductase 4 [Homo sapiens]
Length = 237
Score = 50.8 bits (120), Expect = 1e-06
Identities = 56/216 (25%), Positives = 92/216 (42%), Gaps = 21/216 (9%)
Query: 9 VCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPA 68
VC + G SRG GR +A L+A G L + ARN E + +LG + +
Sbjct: 4 VCAVFGGSRGIGRAVAQLMA---RKGYRLAVIARNLEGAKAAAGDLGGDH-----LAFSC 55
Query: 69 DLGAEAGLQQLLGALRELPRPKGLQRL-LLINNAGSLGDVSKGFVDLSDSTQVNNYWALN 127
D+ E +Q L K L R+ L+N AG D G + + + + + N
Sbjct: 56 DVAKEHDVQNTFEELE-----KHLGRVNFLVNAAGINRD---GLLVRTKTEDMVSQLHTN 107
Query: 128 LTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALE 187
L + + ++ G ++VN+ S+ L+ G ++Y A K + LA E
Sbjct: 108 LLGSMLTCKAAMRTMIQQQG--GSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKE 165
Query: 188 --EPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKG 221
+RV APG + TDM + +E + ++ G
Sbjct: 166 VARKKIRVNVVAPGFVHTDMTKDLKEEHLKKNIPLG 201
>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
Length = 278
Score = 49.7 bits (117), Expect = 3e-06
Identities = 60/234 (25%), Positives = 104/234 (44%), Gaps = 19/234 (8%)
Query: 5 LGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVV 64
L V L+T ++ G G +A LA G+ +V+S+R + + Q A L E GL V
Sbjct: 30 LANKVALVTASTDGIGFAIARRLAQ---DGAHVVVSSRKQQNVDQAVATLQGE--GLSVT 84
Query: 65 RVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQV--NN 122
+G ++L+ +L G+ +L++NA V+ F + D T+ +
Sbjct: 85 GTVCHVGKAEDRERLVATAVKLHG--GID--ILVSNAA----VNPFFGSIMDVTEEVWDK 136
Query: 123 YWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQ 182
+N+ + +T +V+ G +VV +SS+ A P G++ Y K A L +
Sbjct: 137 TLDINVKAPALMTKAVVPEMEKRGG--GSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTK 194
Query: 183 VLALE--EPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDC 234
LA+E N+RV APG + T ++ + K ++ G+ DC
Sbjct: 195 TLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDC 248
>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
sapiens]
Length = 300
Score = 48.9 bits (115), Expect = 4e-06
Identities = 58/212 (27%), Positives = 97/212 (45%), Gaps = 18/212 (8%)
Query: 2 EGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGL 61
+G L V ++TG++ G G +A LA G+ +V+S+R + + + A+L E GL
Sbjct: 31 KGVLANRVAVVTGSTSGIGFAIARRLAR---DGAHVVISSRKQQNVDRAMAKLQGE--GL 85
Query: 62 RVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQV- 120
V + +G +QL+ + L G+ L+ +AG V L S Q+
Sbjct: 86 SVAGIVCHVGKAEDREQLVA--KALEHCGGVD--FLVCSAGVNPLVGS---TLGTSEQIW 138
Query: 121 NNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDML 180
+ ++N+ S L S +L + G V+ +SS+ A P +Y K A L
Sbjct: 139 DKILSVNVKSPALLLSQLLPYMENRRG---AVILVSSIAAYNPVVALGVYNVSKTALLGL 195
Query: 181 FQVLALE--EPNVRVLNYAPGPLDTDMQQLAR 210
+ LALE ++RV PG + TD ++ R
Sbjct: 196 TRTLALELAPKDIRVNCVVPGIIKTDFSKVVR 227
>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
sapiens]
Length = 280
Score = 47.4 bits (111), Expect = 1e-05
Identities = 62/236 (26%), Positives = 104/236 (44%), Gaps = 18/236 (7%)
Query: 2 EGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGL 61
+G L V ++TG++ G G +A LA G+ +V+S+R + + + A+L E GL
Sbjct: 31 KGVLANRVAVVTGSTSGIGFAIARRLAR---DGAHVVISSRKQQNVDRAMAKLQGE--GL 85
Query: 62 RVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQV- 120
V + +G +QL+ + L G+ L+ +AG V L S Q+
Sbjct: 86 SVAGIVCHVGKAEDREQLVA--KALEHCGGVD--FLVCSAGVNPLVGS---TLGTSEQIW 138
Query: 121 NNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDML 180
+ ++N+ S L S +L + G V+ +SS+ A P +Y K A L
Sbjct: 139 DKILSVNVKSPALLLSQLLPYMENRRG---AVILVSSIAAYNPVVALGVYNVSKTALLGL 195
Query: 181 FQVLALE--EPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDC 234
+ LALE ++RV PG + TD ++ K +L+ G+ DC
Sbjct: 196 TRTLALELAPKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFKEHHQLQRIGESEDC 251
>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
[Homo sapiens]
Length = 266
Score = 46.2 bits (108), Expect = 3e-05
Identities = 67/270 (24%), Positives = 116/270 (42%), Gaps = 37/270 (13%)
Query: 9 VCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPA 68
V L+TGA++G GR A +LL G+ + L N EA Q +A L + + + +
Sbjct: 7 VALVTGAAQGIGRAFAE---ALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQC 63
Query: 69 DLGAEAGLQQLLGALRELPRPKGLQRL-LLINNAGSLGDVSKGFVDLSDSTQVNNYWALN 127
D+ A QQL R++ G RL +L+NNAG +++ +N
Sbjct: 64 DV---ADQQQLRDTFRKVVDHFG--RLDILVNNAG-----------VNNEKNWEKTLQIN 107
Query: 128 LTSMLCLTSSVLKAFP-DSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLAL 186
L S++ T L + G ++N+SSL L P +YCA K + AL
Sbjct: 108 LVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAAL 167
Query: 187 E----EPNVRVLNYAPGPLDTD-MQQLARETSVDP--DMRKGLQELKAKGKLVDCKVSAQ 239
VR+ PG ++T ++ + +E ++ + + ++++ ++D + A
Sbjct: 168 AANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIAN 227
Query: 240 KLLSLLEKDEF---------KSGAHVDFYD 260
L++L+E D G H YD
Sbjct: 228 GLITLIEDDALNGAIMKITTSKGIHFQDYD 257
>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
Length = 312
Score = 44.7 bits (104), Expect = 8e-05
Identities = 53/221 (23%), Positives = 97/221 (43%), Gaps = 18/221 (8%)
Query: 2 EGGLGRAV---CLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAER 58
E G+G + ++TG++ G G++ A LA G +VL +R+ + L Q+ +E+ E+
Sbjct: 42 EAGVGPGLGEWAVVTGSTDGIGKSYAEELAK---HGMKVVLISRSKDKLDQVSSEI-KEK 97
Query: 59 SGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSD-S 117
+ + D +E ++ L GL+ +L+NN G + + F+D+ D
Sbjct: 98 FKVETRTIAVDFASEDIYDKIKTGLA------GLEIGILVNNVGMSYEYPEYFLDVPDLD 151
Query: 118 TQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAAR 177
+ +N+ S+ +T VL + ++NISS + P +Y A K
Sbjct: 152 NVIKKMININILSVCKMTQLVLPGMVERS--KGAILNISSGSGMLPVPLLTIYSATKTFV 209
Query: 178 DMLFQVLALE--EPNVRVLNYAPGPLDTDMQQLARETSVDP 216
D Q L E V V + P + T + ++ + T P
Sbjct: 210 DFFSQCLHEEYRSKGVFVQSVLPYFVATKLAKIRKPTLDKP 250
>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
Length = 309
Score = 44.3 bits (103), Expect = 1e-04
Identities = 50/168 (29%), Positives = 73/168 (43%), Gaps = 13/168 (7%)
Query: 9 VCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPA 68
+ L+TGA G GR LA A L GSVLVL N E + ++ E RV
Sbjct: 42 IVLITGAGSGLGRLLALQFARL---GSVLVLWDINKEG-NEETCKMAREAGATRVHAYTC 97
Query: 69 DLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNL 128
D + G+ ++ +++ +LINNAG + K F+D D ++ +N
Sbjct: 98 DCSQKEGVYRVADQVKKEVGDVS----ILINNAGIV--TGKKFLDCPDELMEKSF-DVNF 150
Query: 129 TSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAA 176
+ L + L A + + +V ISS L G A YCA K A
Sbjct: 151 KAHLWTYKAFLPAMIAND--HGHLVCISSSAGLSGVNGLADYCASKFA 196
>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 2
[Homo sapiens]
Length = 178
Score = 43.9 bits (102), Expect = 1e-04
Identities = 49/168 (29%), Positives = 76/168 (45%), Gaps = 21/168 (12%)
Query: 9 VCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPA 68
V L+TGA++G GR A +LL G+ + L N EA Q +A L + + + +
Sbjct: 7 VALVTGAAQGIGRAFAE---ALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQC 63
Query: 69 DLGAEAGLQQLLGALRELPRPKGLQRL-LLINNAGSLGDVSKGFVDLSDSTQVNNYWALN 127
D+ A QQL R++ G RL +L+NNAG +++ +N
Sbjct: 64 DV---ADQQQLRDTFRKVVDHFG--RLDILVNNAG-----------VNNEKNWEKTLQIN 107
Query: 128 LTSMLCLTSSVLKAFP-DSPGLNRTVVNISSLCALQPFKGWALYCAGK 174
L S++ T L + G ++N+SSL L P +YCA K
Sbjct: 108 LVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASK 155
>gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo
sapiens]
Length = 313
Score = 43.9 bits (102), Expect = 1e-04
Identities = 70/265 (26%), Positives = 115/265 (43%), Gaps = 32/265 (12%)
Query: 1 MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSG 60
M + VC++TGASRG GR +A L G+ + ++ R+ + LR + E A+ G
Sbjct: 1 MAAPMNGQVCVVTGASRGIGRGIA---LQLCKAGATVYITGRHLDTLRVVAQE--AQSLG 55
Query: 61 LRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGS-----LGDVSKGFVDLS 115
+ V V D E+ ++ L ++ R + + +L+NNA + L +K F +
Sbjct: 56 GQCVPVVCDSSQESEVRSL---FEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETP 112
Query: 116 DS--TQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAG 173
S +NN C P GL +V ISS +LQ + Y G
Sbjct: 113 ASMWDDINNVGLRG--HYFCSVYGARLMVPAGQGL---IVVISSPGSLQ-YMFNVPYGVG 166
Query: 174 KAARDMLFQVLA--LEEPNVRVLNYAPGPLDTDM--QQLARETSV-DPDMRK------GL 222
KAA D L A L V ++ PG + T++ + +A+E + DP +++
Sbjct: 167 KAACDKLAADCAHELRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAFSSA 226
Query: 223 QELKAKGKLVDCKVSAQKLLSLLEK 247
+ + GK V + +LSL K
Sbjct: 227 ETTELSGKCVVALATDPNILSLSGK 251
>gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo
sapiens]
Length = 313
Score = 43.9 bits (102), Expect = 1e-04
Identities = 70/265 (26%), Positives = 115/265 (43%), Gaps = 32/265 (12%)
Query: 1 MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSG 60
M + VC++TGASRG GR +A L G+ + ++ R+ + LR + E A+ G
Sbjct: 1 MAAPMNGQVCVVTGASRGIGRGIA---LQLCKAGATVYITGRHLDTLRVVAQE--AQSLG 55
Query: 61 LRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGS-----LGDVSKGFVDLS 115
+ V V D E+ ++ L ++ R + + +L+NNA + L +K F +
Sbjct: 56 GQCVPVVCDSSQESEVRSL---FEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETP 112
Query: 116 DS--TQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAG 173
S +NN C P GL +V ISS +LQ + Y G
Sbjct: 113 ASMWDDINNVGLRG--HYFCSVYGARLMVPAGQGL---IVVISSPGSLQ-YMFNVPYGVG 166
Query: 174 KAARDMLFQVLA--LEEPNVRVLNYAPGPLDTDM--QQLARETSV-DPDMRK------GL 222
KAA D L A L V ++ PG + T++ + +A+E + DP +++
Sbjct: 167 KAACDKLAADCAHELRRHGVSCVSLWPGIVQTELLKEHMAKEEVLQDPVLKQFKSAFSSA 226
Query: 223 QELKAKGKLVDCKVSAQKLLSLLEK 247
+ + GK V + +LSL K
Sbjct: 227 ETTELSGKCVVALATDPNILSLSGK 251
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 43.1 bits (100), Expect = 2e-04
Identities = 55/212 (25%), Positives = 86/212 (40%), Gaps = 28/212 (13%)
Query: 5 LGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVV 64
L AV ++TGA+ G G+ A + + G+ LVL RN AL +L EL A +
Sbjct: 50 LRNAVVVITGATSGLGKECAKVF---YAAGAKLVLCGRNGGALEELIRELTASHATKVQT 106
Query: 65 RVP-------ADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAG--SLGDVSKGFVDLS 115
P D GA ++ A E+ + G +L+NNAG G + VD+
Sbjct: 107 HKPYLVTFDLTDSGA------IVAAAAEILQCFGYVD-ILVNNAGISYRGTIMDTTVDVD 159
Query: 116 DSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKA 175
NY+ + L S + + +V ISS+ + Y A K
Sbjct: 160 KRVMETNYFGPVALTKALLPSMIKRR-------QGHIVAISSIQGKMSIPFRSAYAASKH 212
Query: 176 ARDMLFQVL--ALEEPNVRVLNYAPGPLDTDM 205
A F L +E+ + V +PG + T++
Sbjct: 213 ATQAFFDCLRAEMEQYEIEVTVISPGYIHTNL 244
>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
sapiens]
Length = 302
Score = 42.0 bits (97), Expect = 5e-04
Identities = 53/206 (25%), Positives = 81/206 (39%), Gaps = 16/206 (7%)
Query: 5 LGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVV 64
L R L+TG RG GR LA A +VL R ++ L++ E+ + G
Sbjct: 36 LSRENVLITGGGRGIGRQLAREFAE--RGARKIVLWGRTEKCLKETTEEI--RQMGTECH 91
Query: 65 RVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYW 124
D+G + Q A+RE K +L+NNA + K +D D + +
Sbjct: 92 YFICDVGNREEVYQTAKAVRE----KVGDITILVNNAAVVH--GKSLMDSDDDALLKSQ- 144
Query: 125 ALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVL 184
+N T + L + N +V ++S+ AL G YC KA+ + L
Sbjct: 145 HINTLGQFWTTKAFLPRMLELQ--NGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESL 202
Query: 185 A---LEEPNVRVLNYAPGPLDTDMQQ 207
L+ P V P T+M Q
Sbjct: 203 TLGLLDCPGVSATTVLPFHTSTEMFQ 228
>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 40.8 bits (94), Expect = 0.001
Identities = 54/208 (25%), Positives = 95/208 (45%), Gaps = 38/208 (18%)
Query: 11 LLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEA---ELGAERS-----GLR 62
++TGAS+G GR +A LA + G+ +V++AR+ E L+++ + ELGA + +
Sbjct: 38 IVTGASKGIGREMAYHLAKM---GAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTME 94
Query: 63 VVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDL--SDSTQV 120
+ A+AG +L+G L +L++N+ ++ ++L D V
Sbjct: 95 DMTFAEQFVAQAG--KLMGGL----------DMLILNH------ITNTSLNLFHDDIHHV 136
Query: 121 NNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDML 180
+N S + LT + L S N ++V +SSL + A Y A K A D
Sbjct: 137 RKSMEVNFLSYVVLTVAALPMLKQS---NGSIVVVSSLAGKVAYPMVAAYSASKFALDGF 193
Query: 181 FQVL----ALEEPNVRVLNYAPGPLDTD 204
F + ++ NV + G +DT+
Sbjct: 194 FSSIRKEYSVSRVNVSITLCVLGLIDTE 221
>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 40.8 bits (94), Expect = 0.001
Identities = 54/208 (25%), Positives = 95/208 (45%), Gaps = 38/208 (18%)
Query: 11 LLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEA---ELGAERS-----GLR 62
++TGAS+G GR +A LA + G+ +V++AR+ E L+++ + ELGA + +
Sbjct: 38 IVTGASKGIGREMAYHLAKM---GAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTME 94
Query: 63 VVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDL--SDSTQV 120
+ A+AG +L+G L +L++N+ ++ ++L D V
Sbjct: 95 DMTFAEQFVAQAG--KLMGGL----------DMLILNH------ITNTSLNLFHDDIHHV 136
Query: 121 NNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDML 180
+N S + LT + L S N ++V +SSL + A Y A K A D
Sbjct: 137 RKSMEVNFLSYVVLTVAALPMLKQS---NGSIVVVSSLAGKVAYPMVAAYSASKFALDGF 193
Query: 181 FQVL----ALEEPNVRVLNYAPGPLDTD 204
F + ++ NV + G +DT+
Sbjct: 194 FSSIRKEYSVSRVNVSITLCVLGLIDTE 221
>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
Length = 311
Score = 40.0 bits (92), Expect = 0.002
Identities = 54/202 (26%), Positives = 90/202 (44%), Gaps = 23/202 (11%)
Query: 11 LLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADL 70
L++G S G G LA LA +V + R+ LEA G E G + D+
Sbjct: 9 LISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAG-EALGQTLTVAQLDV 67
Query: 71 GAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTS 130
++ + Q L ++ + +L+NNAG +G V G ++ + N + N
Sbjct: 68 CSDESVAQCLSCIQG-------EVDVLVNNAG-MGLV--GPLEGLSLAAMQNVFDTNFFG 117
Query: 131 MLCLTSSVLKAFPDSPGLNRT----VVNISSLCALQPFKGWALYCAGKAARDMLFQVLAL 186
+ L +VL PG+ R +V ISS+ LQ +Y A K A + F+ LA+
Sbjct: 118 AVRLVKAVL------PGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAI 171
Query: 187 E--EPNVRVLNYAPGPLDTDMQ 206
+ + N+ + PGP+ T+ +
Sbjct: 172 QLLQFNIFISLVEPGPVVTEFE 193
>gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Homo
sapiens]
Length = 315
Score = 39.7 bits (91), Expect = 0.003
Identities = 54/181 (29%), Positives = 80/181 (44%), Gaps = 22/181 (12%)
Query: 11 LLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEA---ELGAERSGLRVVRVP 67
LLTGA+ G G LA A L GS LVL+A + L+++ +LGA +V +
Sbjct: 33 LLTGANAGVGEELAYHYARL---GSHLVLTAHTEALLQKVVGNCRKLGAP----KVFYIA 85
Query: 68 ADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNY-WAL 126
AD+ + + ++ L + GL L+L + G+ + S Q + +
Sbjct: 86 ADMASPEAPESVVQF--ALDKLGGLDYLVLNHIGGAPAGTR------ARSPQATRWLMQV 137
Query: 127 NLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLAL 186
N S + LTS L + DS G ++V +SSL P Y A K A D F L
Sbjct: 138 NFVSYVQLTSRALPSLTDSKG---SLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRR 194
Query: 187 E 187
E
Sbjct: 195 E 195
>gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Homo
sapiens]
Length = 286
Score = 39.7 bits (91), Expect = 0.003
Identities = 54/181 (29%), Positives = 80/181 (44%), Gaps = 22/181 (12%)
Query: 11 LLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEA---ELGAERSGLRVVRVP 67
LLTGA+ G G LA A L GS LVL+A + L+++ +LGA +V +
Sbjct: 33 LLTGANAGVGEELAYHYARL---GSHLVLTAHTEALLQKVVGNCRKLGAP----KVFYIA 85
Query: 68 ADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNY-WAL 126
AD+ + + ++ L + GL L+L + G+ + S Q + +
Sbjct: 86 ADMASPEAPESVVQF--ALDKLGGLDYLVLNHIGGAPAGTR------ARSPQATRWLMQV 137
Query: 127 NLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLAL 186
N S + LTS L + DS G ++V +SSL P Y A K A D F L
Sbjct: 138 NFVSYVQLTSRALPSLTDSKG---SLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRR 194
Query: 187 E 187
E
Sbjct: 195 E 195
>gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]
Length = 387
Score = 38.9 bits (89), Expect = 0.005
Identities = 51/197 (25%), Positives = 82/197 (41%), Gaps = 15/197 (7%)
Query: 11 LLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADL 70
L+TG G G L L L VL+ N +L S L++ D+
Sbjct: 86 LVTGGDCGLGHALCKYLDELGFTVFAGVLN-ENGPGAEELRRTCSPRLSVLQM-----DI 139
Query: 71 GAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTS 130
++ + + + +GL + INNAG LG + G +L T A+N
Sbjct: 140 TKPVQIKDAYSKVAAMLQDRGLWAV--INNAGVLGFPTDG--ELLLMTDYKQCMAVNFFG 195
Query: 131 MLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALE--E 188
+ +T + L S G +VN+SS+ P + A Y + KAA M V+ LE +
Sbjct: 196 TVEVTKTFLPLLRKSKG---RLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSK 252
Query: 189 PNVRVLNYAPGPLDTDM 205
++V + PG T++
Sbjct: 253 WGIKVASIQPGGFLTNI 269
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 38.9 bits (89), Expect = 0.005
Identities = 57/206 (27%), Positives = 87/206 (42%), Gaps = 25/206 (12%)
Query: 9 VCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLR---VVR 65
V +TGAS G G LA L+ L G LVLSAR L +++ E L+ ++
Sbjct: 52 VVWVTGASSGIGEELAYQLSKL---GVSLVLSARRVHELERVKRRC-LENGNLKEKDILV 107
Query: 66 VPADLGAEAGLQQLL--GALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQV-NN 122
+P DL + G + L+E R +L+NN G +S+ + + S V
Sbjct: 108 LPLDL-TDTGSHEAATKAVLQEFGRID-----ILVNNGG----MSQRSLCMDTSLDVYRK 157
Query: 123 YWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQ 182
LN + LT VL + +V ++S+ + YCA K A F
Sbjct: 158 LIELNYLGTVSLTKCVLPHMIERK--QGKIVTVNSILGIISVPLSIGYCASKHALRGFFN 215
Query: 183 VLALE---EPNVRVLNYAPGPLDTDM 205
L E P + V N PGP+ +++
Sbjct: 216 GLRTELATYPGIIVSNICPGPVQSNI 241
>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
[Homo sapiens]
Length = 232
Score = 36.6 bits (83), Expect = 0.023
Identities = 52/193 (26%), Positives = 87/193 (45%), Gaps = 19/193 (9%)
Query: 5 LGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVV 64
L V L+T ++ G G +A LA + +V+S+R + + Q A L E GL V
Sbjct: 30 LTNKVALVTASTDGIGFAIARRLAQ---DRAHVVVSSRKQQNVDQAVATLQGE--GLSVT 84
Query: 65 RVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQV--NN 122
+G ++L+ +L G+ +L++NA V+ F L D T+ +
Sbjct: 85 GTVCHVGKAEDRERLVAMAVKLHG--GID--ILVSNAA----VNPFFGSLMDVTEEVWDK 136
Query: 123 YWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQ 182
+N+ + +T +V+ G +VV +SS+ A P G++ Y K A L
Sbjct: 137 TLDINVKAPALMTKAVVPEMEKRGG--GSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNN 194
Query: 183 VLALE--EPNVRV 193
LA+E N+RV
Sbjct: 195 TLAIELAPRNIRV 207
>gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
[Homo sapiens]
Length = 261
Score = 34.3 bits (77), Expect = 0.11
Identities = 48/202 (23%), Positives = 81/202 (40%), Gaps = 13/202 (6%)
Query: 9 VCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPA 68
V ++TG + G G A L + +L L EA A++ G V PA
Sbjct: 12 VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQ--------AKKLGNNCVFAPA 63
Query: 69 DLGAEAGLQQLLGALR-ELPRPKGLQRLLLINNAGSLGDVSKGFVD-LSDSTQVNNYWAL 126
D+ +E +Q L + + R I A ++ KG L D +V + +
Sbjct: 64 DVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLM 123
Query: 127 NLTSMLCLTSSVL-KAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLA 185
+++ L + + + PD G ++N +S+ A + G A Y A K + +A
Sbjct: 124 GTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIA 183
Query: 186 --LEEPNVRVLNYAPGPLDTDM 205
L +RV+ APG T +
Sbjct: 184 RDLAPIGIRVMTIAPGLFGTPL 205
>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
Length = 261
Score = 33.9 bits (76), Expect = 0.15
Identities = 63/256 (24%), Positives = 101/256 (39%), Gaps = 24/256 (9%)
Query: 1 MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSG 60
++ L A+ L+TGA G GR ++ LA G+ + + A ++ LG S
Sbjct: 5 LQNRLRSALALVTGAGSGIGRAVSVRLAG---EGATVAACDLDRAAAQETVRLLGGPGSK 61
Query: 61 LRVVR-----VPADLGAEAGLQQLLGALRE-LPRPKGLQRLLLINNAGSLGDVSKGFVDL 114
R AD+ + LL ++ RP + +++ AG D +
Sbjct: 62 EGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSV----VVSCAGITQDEFLLHMSE 117
Query: 115 SDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGK 174
D +V A+NL +T + +A S G +++NISS+ G Y A K
Sbjct: 118 DDWDKVI---AVNLKGTFLVTQAAAQALV-SNGCRGSIINISSIVGKVGNVGQTNYAASK 173
Query: 175 AARDMLFQVLALE--EPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLV 232
A L Q A E +R + PG + T M Q + VD + E+ G L
Sbjct: 174 AGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDK-----ITEMIPMGHLG 228
Query: 233 DCKVSAQKLLSLLEKD 248
D + A + L +D
Sbjct: 229 DPEDVADVVAFLASED 244
>gi|4502601 carbonyl reductase 3 [Homo sapiens]
Length = 277
Score = 32.7 bits (73), Expect = 0.33
Identities = 49/161 (30%), Positives = 71/161 (44%), Gaps = 23/161 (14%)
Query: 9 VCLLTGASRGFGRTLAPLLASLLSPGSVLVLS--ARNDEALRQLEAELGAERSGLRVVRV 66
V L+TGA+RG G +A L S VL AR A++QL+AE GL
Sbjct: 7 VALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAE------GLS---- 56
Query: 67 PADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSL--GDVSKGFVDLSDSTQVNNYW 124
P + Q + ALR+ R + +L+NNA D F ++ T N++
Sbjct: 57 PRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFF 116
Query: 125 ALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFK 165
A T +C + +L + VVNISSL L+ F+
Sbjct: 117 A---TRNMC--NELLPIMKP----HGRVVNISSLQCLRAFE 148
>gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo
sapiens]
Length = 336
Score = 32.3 bits (72), Expect = 0.43
Identities = 60/217 (27%), Positives = 88/217 (40%), Gaps = 31/217 (14%)
Query: 11 LLTGASRGFGRTLAPLLASLLSPGSVLVLS----ARNDEALRQLEAEL----------GA 56
L+TGA+ G GR A A LL G+ +++ AR +EA QL EL G
Sbjct: 47 LITGANSGLGRATA---AELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGV 103
Query: 57 ERSGLRVVRVPADLGAEAGLQQLL-GALRELPRPKGLQRLLLINNAGSLG----DVSKGF 111
G +VR DL + ++ L+E PR +LINNAG GF
Sbjct: 104 SGVGELIVR-ELDLASLRSVRAFCQEMLQEEPRLD-----VLINNAGIFQCPYMKTEDGF 157
Query: 112 VDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNR-TVVNISSLCALQPFKGWALY 170
+ ++ NL L +S+ + S L + +N L + Q + Y
Sbjct: 158 EMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCY 217
Query: 171 CAGKAARDMLFQVLA--LEEPNVRVLNYAPGPLDTDM 205
K A + + LA LE NV V PG + T++
Sbjct: 218 SRSKLANILFTRELARRLEGTNVTVNVLHPGIVRTNL 254
>gi|223646115 short chain dehydrogenase/reductase family 16C, member
6 [Homo sapiens]
Length = 323
Score = 32.0 bits (71), Expect = 0.56
Identities = 46/210 (21%), Positives = 83/210 (39%), Gaps = 27/210 (12%)
Query: 9 VCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPA 68
+ L TGA G GR LA A G++LVL N E + L E+ G +V
Sbjct: 38 IVLTTGAGSGLGRQLAIYFARF---GAILVLWDVNQEGNME-TCRLAKEKGGKKVFPYTC 93
Query: 69 DLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDS--------TQV 120
D + ++ +R+ + +L+NNA + K F+D+ D +
Sbjct: 94 DCSNRQEVYRVADQVRK----EFGDVTILVNNADLV--TGKPFLDIPDHMVEKSFLVNAI 147
Query: 121 NNYWALN--LTSMLCLTSSVLKAFPDSPGLNRTVVNISSLC---ALQPFKGWALYCAGKA 175
++W L +++ L G VV I+ L + P+ + + A
Sbjct: 148 THFWTCKAFLPAVIKANHGHLVCISSIAG----VVGINGLSDEYFVSPYYSASKFAAFGF 203
Query: 176 ARDMLFQVLALEEPNVRVLNYAPGPLDTDM 205
A + F++ +++ V+ P ++T M
Sbjct: 204 AESLFFELTMIKKTEVKSTIVCPHFINTGM 233
>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 32.0 bits (71), Expect = 0.56
Identities = 46/175 (26%), Positives = 82/175 (46%), Gaps = 20/175 (11%)
Query: 5 LGRAVCLLTGASRGFGRTLAPLLAS---LLSPGSVLVLSARNDEALRQLEAELGAERSGL 61
+G L+TG GFG +LA L S L+ G ++ + + +++L++ L ++R L
Sbjct: 53 VGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAG--CLMKDKGHDGVKELDS-LNSDR--L 107
Query: 62 RVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAG--SLGDVSKGFVDLSDSTQ 119
R V++ ++ + +++++ +R + L+NNAG + G+V F L Q
Sbjct: 108 RTVQL--NVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVE--FTSLETYKQ 163
Query: 120 VNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGK 174
V +NL + +T S L + G VVNISS+ + YC K
Sbjct: 164 VAE---VNLWGTVRMTKSFLPLIRRAKG---RVVNISSMLGRMANPARSPYCITK 212
>gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 32.0 bits (71), Expect = 0.56
Identities = 46/175 (26%), Positives = 82/175 (46%), Gaps = 20/175 (11%)
Query: 5 LGRAVCLLTGASRGFGRTLAPLLAS---LLSPGSVLVLSARNDEALRQLEAELGAERSGL 61
+G L+TG GFG +LA L S L+ G ++ + + +++L++ L ++R L
Sbjct: 53 VGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAG--CLMKDKGHDGVKELDS-LNSDR--L 107
Query: 62 RVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAG--SLGDVSKGFVDLSDSTQ 119
R V++ ++ + +++++ +R + L+NNAG + G+V F L Q
Sbjct: 108 RTVQL--NVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVE--FTSLETYKQ 163
Query: 120 VNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGK 174
V +NL + +T S L + G VVNISS+ + YC K
Sbjct: 164 VAE---VNLWGTVRMTKSFLPLIRRAKG---RVVNISSMLGRMANPARSPYCITK 212
>gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 32.0 bits (71), Expect = 0.56
Identities = 46/175 (26%), Positives = 82/175 (46%), Gaps = 20/175 (11%)
Query: 5 LGRAVCLLTGASRGFGRTLAPLLAS---LLSPGSVLVLSARNDEALRQLEAELGAERSGL 61
+G L+TG GFG +LA L S L+ G ++ + + +++L++ L ++R L
Sbjct: 53 VGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAG--CLMKDKGHDGVKELDS-LNSDR--L 107
Query: 62 RVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAG--SLGDVSKGFVDLSDSTQ 119
R V++ ++ + +++++ +R + L+NNAG + G+V F L Q
Sbjct: 108 RTVQL--NVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVE--FTSLETYKQ 163
Query: 120 VNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGK 174
V +NL + +T S L + G VVNISS+ + YC K
Sbjct: 164 VAE---VNLWGTVRMTKSFLPLIRRAKG---RVVNISSMLGRMANPARSPYCITK 212
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,343,162
Number of Sequences: 37866
Number of extensions: 381927
Number of successful extensions: 1063
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 49
Number of HSP's that attempted gapping in prelim test: 1048
Number of HSP's gapped (non-prelim): 70
length of query: 261
length of database: 18,247,518
effective HSP length: 100
effective length of query: 161
effective length of database: 14,460,918
effective search space: 2328207798
effective search space used: 2328207798
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.