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Search of human proteins with 4505809
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo
sapiens]
(828 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo sa... 1645 0.0
gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 ... 193 5e-49
gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform ... 193 5e-49
gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase... 132 1e-30
gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypept... 124 5e-28
gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapi... 119 2e-26
gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypept... 114 4e-25
gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide... 113 8e-25
gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptid... 112 1e-24
gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptid... 108 3e-23
gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo sa... 104 4e-22
gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo... 100 7e-21
gi|4826730 FK506 binding protein 12-rapamycin associated protein... 54 8e-07
gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens] 48 3e-05
gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens] 48 3e-05
gi|13654237 protein kinase, DNA-activated, catalytic polypeptide... 48 3e-05
gi|157266317 ataxia telangiectasia and Rad3 related protein [Hom... 48 3e-05
gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, pa... 48 3e-05
gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad... 48 3e-05
gi|126032350 protein kinase, DNA-activated, catalytic polypeptid... 48 4e-05
gi|113430845 PREDICTED: similar to protein kinase, DNA-activated... 48 4e-05
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 37 0.057
gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens] 37 0.098
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 35 0.29
gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens] 33 1.1
gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens] 33 1.1
gi|46255064 synaptotagmin-like 2 isoform d [Homo sapiens] 33 1.1
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 33 1.1
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] 32 1.8
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 32 1.8
>gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo
sapiens]
Length = 828
Score = 1645 bits (4259), Expect = 0.0
Identities = 828/828 (100%), Positives = 828/828 (100%)
Query: 1 MRFLEARSLAVAMGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVA 60
MRFLEARSLAVAMGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVA
Sbjct: 1 MRFLEARSLAVAMGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVA 60
Query: 61 QKACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAV 120
QKACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAV
Sbjct: 61 QKACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAV 120
Query: 121 ASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFR 180
ASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFR
Sbjct: 121 ASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFR 180
Query: 181 NEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQ 240
NEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQ
Sbjct: 181 NEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQ 240
Query: 241 RHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSN 300
RHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSN
Sbjct: 241 RHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSN 300
Query: 301 LKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQK 360
LKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQK
Sbjct: 301 LKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQK 360
Query: 361 TQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECEN 420
TQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECEN
Sbjct: 361 TQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECEN 420
Query: 421 FDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQ 480
FDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQ
Sbjct: 421 FDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQ 480
Query: 481 VELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDP 540
VELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDP
Sbjct: 481 VELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDP 540
Query: 541 SAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQ 600
SAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQ
Sbjct: 541 SAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQ 600
Query: 601 ERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLS 660
ERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLS
Sbjct: 601 ERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLS 660
Query: 661 AQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAF 720
AQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAF
Sbjct: 661 AQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAF 720
Query: 721 KLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSST 780
KLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSST
Sbjct: 721 KLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSST 780
Query: 781 IRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM 828
IRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
Sbjct: 781 IRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM 828
>gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1
[Homo sapiens]
Length = 854
Score = 193 bits (491), Expect = 5e-49
Identities = 105/267 (39%), Positives = 166/267 (62%), Gaps = 7/267 (2%)
Query: 563 GHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMI 622
G +W+ + I K GDD RQ++LA Q++ ++I++ + L++ PY+++ + G+I
Sbjct: 591 GQKISWQ--AAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVI 648
Query: 623 EPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVK 682
E + + S Q+ +Q+ + DYF +++G +T AF A+ NF++S A Y L+ +LLQ+K
Sbjct: 649 ECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIK 708
Query: 683 DRHNGNILLDAEGHIIHIDFGFILSSSP-RNLGFETSAFKLTTEFVDVMGG-LDGDMFNY 740
DRHNGNI+LD +GHIIHIDFGF+ SSP NLG+E KLT E V +MGG ++ F +
Sbjct: 709 DRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPD-IKLTDEMVMIMGGKMEATPFKW 767
Query: 741 YKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLL 800
+ + ++G +A R +MD VV +V +M + LPCF G TI+ LK RF +MTE +
Sbjct: 768 FMEMCVRGYLAVRPYMDAVVSLVTLMLD-TGLPCFRG-QTIKLLKHRFSPNMTEREAANF 825
Query: 801 VEQMVDGSMRSITTKLYDGFQYLTNGI 827
+ +++ S ++ YD QY N I
Sbjct: 826 IMKVIQSCFLSNRSRTYDMIQYYQNDI 852
>gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform 2
[Homo sapiens]
Length = 2044
Score = 193 bits (491), Expect = 5e-49
Identities = 105/267 (39%), Positives = 166/267 (62%), Gaps = 7/267 (2%)
Query: 563 GHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMI 622
G +W+ + I K GDD RQ++LA Q++ ++I++ + L++ PY+++ + G+I
Sbjct: 1781 GQKISWQ--AAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVI 1838
Query: 623 EPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVK 682
E + + S Q+ +Q+ + DYF +++G +T AF A+ NF++S A Y L+ +LLQ+K
Sbjct: 1839 ECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIK 1898
Query: 683 DRHNGNILLDAEGHIIHIDFGFILSSSP-RNLGFETSAFKLTTEFVDVMGG-LDGDMFNY 740
DRHNGNI+LD +GHIIHIDFGF+ SSP NLG+E KLT E V +MGG ++ F +
Sbjct: 1899 DRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPD-IKLTDEMVMIMGGKMEATPFKW 1957
Query: 741 YKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLL 800
+ + ++G +A R +MD VV +V +M + LPCF G TI+ LK RF +MTE +
Sbjct: 1958 FMEMCVRGYLAVRPYMDAVVSLVTLMLD-TGLPCFRG-QTIKLLKHRFSPNMTEREAANF 2015
Query: 801 VEQMVDGSMRSITTKLYDGFQYLTNGI 827
+ +++ S ++ YD QY N I
Sbjct: 2016 IMKVIQSCFLSNRSRTYDMIQYYQNDI 2042
>gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase
type 3 alpha [Homo sapiens]
Length = 286
Score = 132 bits (333), Expect = 1e-30
Identities = 62/148 (41%), Positives = 100/148 (67%), Gaps = 2/148 (1%)
Query: 563 GHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMI 622
G +W+ + I K GDD RQ++LA Q++ ++I++ + L++ PY+++ + G+I
Sbjct: 45 GQKISWQ--AAIFKLGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVI 102
Query: 623 EPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVK 682
E + + S Q+ +Q+ + DYF +++G +T AF A+ NF++S A Y L+ +LLQ+K
Sbjct: 103 ECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIK 162
Query: 683 DRHNGNILLDAEGHIIHIDFGFILSSSP 710
DRHNGNI+LD +GHIIHIDFGF+ SSP
Sbjct: 163 DRHNGNIMLDKKGHIIHIDFGFMFESSP 190
>gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypeptide
[Homo sapiens]
Length = 1102
Score = 124 bits (310), Expect = 5e-28
Identities = 81/269 (30%), Positives = 140/269 (52%), Gaps = 14/269 (5%)
Query: 571 LSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVS 630
+ +I K GDDLRQ++L Q+L+ ++SIWE E + L + PY + GMIE V +A +
Sbjct: 828 IGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATT 887
Query: 631 IHQVKKQS-------QLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKD 683
I ++++ + + +L+++L+E S T E F +A FV SCAGYC+ ++L + D
Sbjct: 888 IAKIQQSTVGNTGAFKDEVLNHWLKEK-SPTEEKFQAAVERFVYSCAGYCVATFVLGIGD 946
Query: 684 RHNGNILLDAEGHIIHIDFGFILSSSPRNLGF--ETSAFKLTTEFVDVM---GGLDGDMF 738
RHN NI++ G++ HIDFG IL + LG E F LT +F+ VM G F
Sbjct: 947 RHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHF 1006
Query: 739 NYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQ 798
++ + ++ +A R H + ++ + +M + +P I +++ + EE +
Sbjct: 1007 QKFQDICVKAYLALRHHTNLLIILFSMMLM-TGMPQLTSKEDIEYIRDALTVGKNEEDAK 1065
Query: 799 LLVEQMVDGSMRSITTKLYDGFQYLTNGI 827
++ T ++ F +L GI
Sbjct: 1066 KYFLDQIEVCRDKGWTVQFNWFLHLVLGI 1094
>gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo
sapiens]
Length = 887
Score = 119 bits (297), Expect = 2e-26
Identities = 70/258 (27%), Positives = 137/258 (53%), Gaps = 14/258 (5%)
Query: 573 VIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIH 632
VI K GDDLRQ+ L Q++ + + +E + L + PYK+L S G ++ + +V +
Sbjct: 633 VIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQ-FIQSVPVA 691
Query: 633 QVKKQSQLSLLDYFLQEHGSYTTEAFLSAQ--RNFVQSCAGYCLVCYLLQVKDRHNGNIL 690
+V ++ S+ ++F + S +SA+ +V+SCAGYC++ Y+L V DRH N+L
Sbjct: 692 EVL-DTEGSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLL 750
Query: 691 LDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLI 750
L G + HIDFG+IL P+ L KL E V+ MGG + + ++ +
Sbjct: 751 LTKTGKLFHIDFGYILGRDPKPL---PPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFL 807
Query: 751 AARKHMDKVVQIVEIMQQGSQLP--CFHGSSTIRNLKERFHMSMTEEQ----LQLLVEQM 804
R++ + ++ + +M + +P T++ ++++F + +++E+ +Q L+++
Sbjct: 808 HLRRYSNLILNLFSLMVD-ANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDES 866
Query: 805 VDGSMRSITTKLYDGFQY 822
V ++ +++ QY
Sbjct: 867 VHALFAAVVEQIHKFAQY 884
>gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypeptide
[Homo sapiens]
Length = 1068
Score = 114 bits (285), Expect = 4e-25
Identities = 76/260 (29%), Positives = 134/260 (51%), Gaps = 19/260 (7%)
Query: 573 VIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIH 632
+I K GDDLRQ++L Q+++ +++IW+ + + L + PY L I G+IE V N+ +I
Sbjct: 799 IIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIM 858
Query: 633 QVKKQSQLS--------LLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDR 684
Q++ + L L +L++ E + +A F +SCAGYC+ ++L + DR
Sbjct: 859 QIQCKGGLKGALQFNSHTLHQWLKDKNK--GEIYDAAIDLFTRSCAGYCVATFILGIGDR 916
Query: 685 HNGNILLDAEGHIIHIDFGFILSSSPRNLGF--ETSAFKLTTEFVDVMGGLDGDM----- 737
HN NI++ +G + HIDFG L + G+ E F LT +F+ V+ +
Sbjct: 917 HNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTRE 976
Query: 738 FNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTE-EQ 796
F ++ + + +A R+H + + + +M GS +P I +++ + TE E
Sbjct: 977 FERFQEMCYKAYLAIRQHANLFINLFSMM-LGSGMPELQSFDDIAYIRKTLALDKTEQEA 1035
Query: 797 LQLLVEQMVDGSMRSITTKL 816
L+ ++QM D TTK+
Sbjct: 1036 LEYFMKQMNDAHHGGWTTKM 1055
>gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide
[Homo sapiens]
Length = 1634
Score = 113 bits (282), Expect = 8e-25
Identities = 73/257 (28%), Positives = 128/257 (49%), Gaps = 14/257 (5%)
Query: 571 LSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVS 630
+ VI KCGDDLRQ++L Q+++ + IW QE + + + ++ GM+E + NA +
Sbjct: 1078 IRVIFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAET 1137
Query: 631 IHQVKKQSQLS-------LLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKD 683
+ +++ + ++ L D+ LQ+H E + A NF+ SCAG C+ Y+L + D
Sbjct: 1138 LRKIQVEHGVTGSFKDRPLADW-LQKHNPGEDE-YEKAVENFIYSCAGCCVATYVLGICD 1195
Query: 684 RHNGNILLDAEGHIIHIDFGFILSSSPR--NLGFETSAFKLTTEFVDVMGGLD--GDMFN 739
RHN NI+L GH+ HIDFG L + N+ + + F T++ V+ G D F+
Sbjct: 1196 RHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFH 1255
Query: 740 YYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQL 799
+ L Q RKH + ++ +M +P ++ + + TE
Sbjct: 1256 DFVDLCCQAYNLIRKHTHLFLNLLGLM-LSCGIPELSDLEDLKYVYDALRPQDTEANATT 1314
Query: 800 LVEQMVDGSMRSITTKL 816
++++ S+ S+ TKL
Sbjct: 1315 YFTRLIESSLGSVATKL 1331
>gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptide
[Homo sapiens]
Length = 1445
Score = 112 bits (280), Expect = 1e-24
Identities = 65/211 (30%), Positives = 111/211 (52%), Gaps = 11/211 (5%)
Query: 566 PNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPV 625
P + +S+I K GDDLRQ++L Q+++ + +IW QE + + + Y+ L D G+++ V
Sbjct: 911 PMGKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMV 970
Query: 626 VNAVSIHQVKKQSQL------SLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLL 679
+AV++ ++ + S L + + + +H + + A RNF SCAG+C+V ++L
Sbjct: 971 PDAVTLAKIHRHSGLIGPLKENTIKKWFSQHNHLKAD-YEKALRNFFYSCAGWCVVTFIL 1029
Query: 680 QVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETS----AFKLTTEFVDVMGGLDG 735
V DRHN NI+L GH+ HIDFG L + G + F E+ GG +
Sbjct: 1030 GVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNP 1089
Query: 736 DMFNYYKMLMLQGLIAARKHMDKVVQIVEIM 766
F + L + RKH ++ ++E+M
Sbjct: 1090 QHFQDFVELCCRAYNIIRKHSQLLLNLLEMM 1120
>gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptide
[Homo sapiens]
Length = 1686
Score = 108 bits (269), Expect = 3e-23
Identities = 71/255 (27%), Positives = 133/255 (52%), Gaps = 12/255 (4%)
Query: 571 LSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVS 630
++V+ K G+DLRQ++LA Q++K + IW +E + L + +K L D GM+E V + +
Sbjct: 1133 INVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDT 1192
Query: 631 IHQVKKQSQLS------LLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDR 684
+ +++ + ++ L +L+++ + E + A NF+ SCAG C+ Y+L + DR
Sbjct: 1193 LRKIQVEYGVTGSFKDKPLAEWLRKYNP-SEEEYEKASENFIYSCAGCCVATYVLGICDR 1251
Query: 685 HNGNILLDAEGHIIHIDFGFILSSSPRNLGF--ETSAFKLTTEFVDVMGGLDGD--MFNY 740
HN NI+L + GH+ HIDFG L + F + + F LT++ V+ G + F
Sbjct: 1252 HNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRFQL 1311
Query: 741 YKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLL 800
+ L Q RK + + ++ +M S LP ++ +++ T+ + +
Sbjct: 1312 FVDLCCQAYNLIRKQTNLFLNLLSLMIP-SGLPELTSIQDLKYVRDALQPQTTDAEATIF 1370
Query: 801 VEQMVDGSMRSITTK 815
++++ S+ SI TK
Sbjct: 1371 FTRLIESSLGSIATK 1385
>gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo
sapiens]
Length = 1070
Score = 104 bits (259), Expect = 4e-22
Identities = 79/262 (30%), Positives = 130/262 (49%), Gaps = 20/262 (7%)
Query: 571 LSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVS 630
+ VI K GDDLRQ++L Q+L+ + +W++ + L + PY L SG+IE V + +
Sbjct: 800 VGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSET 859
Query: 631 IHQVKKQSQL----------SLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQ 680
I ++ S +LL++ L+E+ S + A F SCAGYC+ Y+L
Sbjct: 860 IADIQLNSSNVAAAAAFNKDALLNW-LKEYNS--GDDLDRAIEEFTLSCAGYCVASYVLG 916
Query: 681 VKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGF--ETSAFKLTTEFVDVM-GGLDG-- 735
+ DRH+ NI++ G + HIDFG IL + G E F LT +F+ V+ G G
Sbjct: 917 IGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNT 976
Query: 736 DMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEE 795
+ F ++ + R+H + + + +M LP I+ LK+ + +EE
Sbjct: 977 EKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAG-LPELTSVKDIQYLKDSLALGKSEE 1035
Query: 796 QLQLLVEQMVDGSMR-SITTKL 816
+ +Q D ++R S TTK+
Sbjct: 1036 EALKQFKQKFDEALRESWTTKV 1057
>gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo
sapiens]
Length = 1044
Score = 100 bits (248), Expect = 7e-21
Identities = 69/238 (28%), Positives = 118/238 (49%), Gaps = 13/238 (5%)
Query: 571 LSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVS 630
+ +I K GDDLRQ++L Q+++ + +W+QE + L + PY L +G+IE V+ + +
Sbjct: 774 VGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDT 833
Query: 631 IHQVK-KQSQLSLLDYFLQE------HGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKD 683
I ++ +S ++ F ++ EA A F SCAGYC+ Y+L + D
Sbjct: 834 IANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGD 893
Query: 684 RHNGNILLDAEGHIIHIDFGFILSSSPRNLGF--ETSAFKLTTEFVDVM---GGLDGDMF 738
RH+ NI++ G + HIDFG L + G E F LT +FV V+ + + F
Sbjct: 894 RHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKF 953
Query: 739 NYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQ 796
++ + R+H + + +M + + LP S I+ LK+ + TEE+
Sbjct: 954 ERFRGYCERAYTILRRHGLLFLHLFALM-RAAGLPELSCSKDIQYLKDSLALGKTEEE 1010
>gi|4826730 FK506 binding protein 12-rapamycin associated protein 1
[Homo sapiens]
Length = 2549
Score = 53.5 bits (127), Expect = 8e-07
Identities = 61/239 (25%), Positives = 107/239 (44%), Gaps = 52/239 (21%)
Query: 574 IVKCGDDLRQELLAFQVLKQLQSIWEQE----RVPLWIKPYKILVISADSGMIEPVVNAV 629
++K +DLRQ+ Q+ + ++ + R L I+ Y ++ +S +SG+I V +
Sbjct: 2185 LLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCD 2244
Query: 630 SIHQV------KKQSQLSLL---------DY----FLQ-----EHG-------------- 651
++H + KK+ L++ DY +Q EH
Sbjct: 2245 TLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLW 2304
Query: 652 --SYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLD-AEGHIIHIDFGFILSS 708
S ++E + + N+ +S A +V Y+L + DRH N++LD G I+HIDFG
Sbjct: 2305 LKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEV 2364
Query: 709 SPRNLGF-ETSAFKLTTEFVDVM--GGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVE 764
+ F E F+LT + M GLDG+ Y++ + R+H D V+ ++E
Sbjct: 2365 AMTREKFPEKIPFRLTRMLTNAMEVTGLDGN----YRITCHTVMEVLREHKDSVMAVLE 2419
>gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens]
Length = 1708
Score = 48.1 bits (113), Expect = 3e-05
Identities = 59/242 (24%), Positives = 100/242 (41%), Gaps = 53/242 (21%)
Query: 574 IVKCGDDLRQELLAFQVLKQ----LQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAV 629
+VK DDLRQ+ + QV + LQ E + L I YK++ +S SG++E V
Sbjct: 1367 LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTV 1426
Query: 630 SIHQ-----------------------------VKKQSQLSLLDYFLQEHGSYTT----- 655
I + V+K+S + F+ ++
Sbjct: 1427 PIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYF 1486
Query: 656 --EAFLSA------QRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAE-GHIIHIDFGFIL 706
E FL + + +S A +V Y+L + DRH NIL++ + ++HID G
Sbjct: 1487 CMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAF 1546
Query: 707 SSSPRNLGFETSAFKLTTEFVDVMG--GLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVE 764
ET F+LT + VD MG G++G ++ + + R + ++ IVE
Sbjct: 1547 EQGKILPTPETVPFRLTRDIVDGMGITGVEG----VFRRCCEKTMEVMRNSQETLLTIVE 1602
Query: 765 IM 766
++
Sbjct: 1603 VL 1604
>gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens]
Length = 3056
Score = 48.1 bits (113), Expect = 3e-05
Identities = 59/242 (24%), Positives = 100/242 (41%), Gaps = 53/242 (21%)
Query: 574 IVKCGDDLRQELLAFQVLKQ----LQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAV 629
+VK DDLRQ+ + QV + LQ E + L I YK++ +S SG++E V
Sbjct: 2715 LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTV 2774
Query: 630 SIHQ-----------------------------VKKQSQLSLLDYFLQEHGSYTT----- 655
I + V+K+S + F+ ++
Sbjct: 2775 PIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYF 2834
Query: 656 --EAFLSA------QRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAE-GHIIHIDFGFIL 706
E FL + + +S A +V Y+L + DRH NIL++ + ++HID G
Sbjct: 2835 CMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAF 2894
Query: 707 SSSPRNLGFETSAFKLTTEFVDVMG--GLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVE 764
ET F+LT + VD MG G++G ++ + + R + ++ IVE
Sbjct: 2895 EQGKILPTPETVPFRLTRDIVDGMGITGVEG----VFRRCCEKTMEVMRNSQETLLTIVE 2950
Query: 765 IM 766
++
Sbjct: 2951 VL 2952
>gi|13654237 protein kinase, DNA-activated, catalytic polypeptide
isoform 1 [Homo sapiens]
Length = 4128
Score = 48.1 bits (113), Expect = 3e-05
Identities = 53/221 (23%), Positives = 92/221 (41%), Gaps = 64/221 (28%)
Query: 574 IVKCGDDLRQELLAFQVLKQLQSIWEQERV----PLWIKPYKILVISADSGMIEPVVNAV 629
+VK G+DLRQ+ Q+ + + I Q+ L ++ Y ++ +++ G+IE + N V
Sbjct: 3751 LVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTV 3810
Query: 630 SI--------HQVKKQSQLS---------------------LLDYFLQEHGSYTT----- 655
++ Q +K + LS + Y L G+ T
Sbjct: 3811 TLKDLLLNTMSQEEKAAYLSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTS 3870
Query: 656 ------------------------EAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILL 691
EAFL+ + +F S A C+ ++L + DRH N ++
Sbjct: 3871 FRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMV 3930
Query: 692 DAE-GHIIHIDFGFILSSSPRNLGF-ETSAFKLTTEFVDVM 730
E G +I IDFG S+ + L E F+LT +F+++M
Sbjct: 3931 AMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLM 3971
>gi|157266317 ataxia telangiectasia and Rad3 related protein [Homo
sapiens]
Length = 2644
Score = 48.1 bits (113), Expect = 3e-05
Identities = 67/283 (23%), Positives = 120/283 (42%), Gaps = 55/283 (19%)
Query: 573 VIVKCGDDLRQE--LLAFQVL--KQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNA 628
++ K DDLR++ L+ F L K L+ E R L I+ Y ++ ++ + G+IE V N
Sbjct: 2324 MMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNT 2383
Query: 629 VSIHQV----------------------KKQSQLS-----LLDYFLQEHGSYTTEAFL-- 659
+ + K + LS ++ L H E FL
Sbjct: 2384 AGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRT 2443
Query: 660 --------SAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDA-EGHIIHIDFGFILSSSP 710
S++ + +S A +V Y+L + DRH NIL D+ G +H+DF + +
Sbjct: 2444 FPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGE 2503
Query: 711 RNLGFETSAFKLTTEFVDVMG--GLDGDMFNYYKMLM---------LQGLIAARKHMDKV 759
E F+LT V+ MG G +G ++ M L ++ H D +
Sbjct: 2504 TFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLH-DPL 2562
Query: 760 VQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVE 802
V+ + ++ S+ P + + + N K + H+ E++LQ +++
Sbjct: 2563 VEWSKPVKGHSKAP-LNETGEVVNEKAKTHVLDIEQRLQGVIK 2604
>gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, partial
[Homo sapiens]
Length = 2934
Score = 48.1 bits (113), Expect = 3e-05
Identities = 59/242 (24%), Positives = 100/242 (41%), Gaps = 53/242 (21%)
Query: 574 IVKCGDDLRQELLAFQVLKQ----LQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAV 629
+VK DDLRQ+ + QV + LQ E + L I YK++ +S SG++E V
Sbjct: 2593 LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTV 2652
Query: 630 SIHQ-----------------------------VKKQSQLSLLDYFLQEHGSYTT----- 655
I + V+K+S + F+ ++
Sbjct: 2653 PIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYF 2712
Query: 656 --EAFLSA------QRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAE-GHIIHIDFGFIL 706
E FL + + +S A +V Y+L + DRH NIL++ + ++HID G
Sbjct: 2713 CMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAF 2772
Query: 707 SSSPRNLGFETSAFKLTTEFVDVMG--GLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVE 764
ET F+LT + VD MG G++G ++ + + R + ++ IVE
Sbjct: 2773 EQGKILPTPETVPFRLTRDIVDGMGITGVEG----VFRRCCEKTMEVMRNSQETLLTIVE 2828
Query: 765 IM 766
++
Sbjct: 2829 VL 2830
>gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad3
related protein, partial [Homo sapiens]
Length = 386
Score = 48.1 bits (113), Expect = 3e-05
Identities = 67/283 (23%), Positives = 120/283 (42%), Gaps = 55/283 (19%)
Query: 573 VIVKCGDDLRQE--LLAFQVL--KQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNA 628
++ K DDLR++ L+ F L K L+ E R L I+ Y ++ ++ + G+IE V N
Sbjct: 66 MMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNT 125
Query: 629 VSIHQV----------------------KKQSQLS-----LLDYFLQEHGSYTTEAFL-- 659
+ + K + LS ++ L H E FL
Sbjct: 126 AGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRT 185
Query: 660 --------SAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDA-EGHIIHIDFGFILSSSP 710
S++ + +S A +V Y+L + DRH NIL D+ G +H+DF + +
Sbjct: 186 FPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGE 245
Query: 711 RNLGFETSAFKLTTEFVDVMG--GLDGDMFNYYKMLM---------LQGLIAARKHMDKV 759
E F+LT V+ MG G +G ++ M L ++ H D +
Sbjct: 246 TFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLH-DPL 304
Query: 760 VQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVE 802
V+ + ++ S+ P + + + N K + H+ E++LQ +++
Sbjct: 305 VEWSKPVKGHSKAP-LNETGEVVNEKAKTHVLDIEQRLQGVIK 346
>gi|126032350 protein kinase, DNA-activated, catalytic polypeptide
isoform 2 [Homo sapiens]
Length = 4097
Score = 47.8 bits (112), Expect = 4e-05
Identities = 29/81 (35%), Positives = 47/81 (58%), Gaps = 2/81 (2%)
Query: 652 SYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAE-GHIIHIDFGFILSSSP 710
S + EAFL+ + +F S A C+ ++L + DRH N ++ E G +I IDFG S+
Sbjct: 3860 STSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSAT 3919
Query: 711 RNLGF-ETSAFKLTTEFVDVM 730
+ L E F+LT +F+++M
Sbjct: 3920 QFLPVPELMPFRLTRQFINLM 3940
>gi|113430845 PREDICTED: similar to protein kinase, DNA-activated,
catalytic polypeptide [Homo sapiens]
Length = 4096
Score = 47.8 bits (112), Expect = 4e-05
Identities = 29/81 (35%), Positives = 47/81 (58%), Gaps = 2/81 (2%)
Query: 652 SYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAE-GHIIHIDFGFILSSSP 710
S + EAFL+ + +F S A C+ ++L + DRH N ++ E G +I IDFG S+
Sbjct: 3859 STSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSAT 3918
Query: 711 RNLGF-ETSAFKLTTEFVDVM 730
+ L E F+LT +F+++M
Sbjct: 3919 QFLPVPELMPFRLTRQFINLM 3939
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 37.4 bits (85), Expect = 0.057
Identities = 31/114 (27%), Positives = 54/114 (47%), Gaps = 16/114 (14%)
Query: 232 SSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGL--------SPSKRT 283
SS S+ S G+ L ++P + +PS +PAP + +P+KR
Sbjct: 2552 SSSSSGSSSSDSEGSSL-------PVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRK 2604
Query: 284 HQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPE 337
+RS S +++S S SS+ ++S+ + SSS+ S +S SP + P+
Sbjct: 2605 -RRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQ 2657
>gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]
Length = 3661
Score = 36.6 bits (83), Expect = 0.098
Identities = 21/85 (24%), Positives = 41/85 (48%), Gaps = 3/85 (3%)
Query: 654 TTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLD-AEGHIIHIDFGFILSSSPRN 712
T + + +++ +S A +V Y++ + DRH N+L+D G ++HID+
Sbjct: 2306 TPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSL 2365
Query: 713 LGFETSAFKLTTEFVDVMG--GLDG 735
E F++T +G G++G
Sbjct: 2366 RVPEKVPFRMTQNIETALGVTGVEG 2390
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 35.0 bits (79), Expect = 0.29
Identities = 33/147 (22%), Positives = 67/147 (45%), Gaps = 21/147 (14%)
Query: 229 GAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSK 288
GA S+ + ++ +R + KLR R+L + + ++ ++ H S
Sbjct: 1158 GATSAQVELNKKREAEFQKLR--------------RDLEEATLQHEAMVAALRKKHADSM 1203
Query: 289 SDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIG 348
++ I NL+R K+E E EL T+ + ++ + + E K ++
Sbjct: 1204 AELGEQID---NLQRVKQ--KLEKEKSELKMETDDLSSNAEAISKAKGNLE--KMCRSLE 1256
Query: 349 KRLATLPTKEQKTQRLISELSLLNHKL 375
+++ L TKE++ QRLI++L+ +L
Sbjct: 1257 DQVSELKTKEEEQQRLINDLTAQRARL 1283
>gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens]
Length = 935
Score = 33.1 bits (74), Expect = 1.1
Identities = 22/64 (34%), Positives = 32/64 (50%), Gaps = 7/64 (10%)
Query: 278 SPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESI-------DNSFSS 330
SP +T +RS + S SL +++ KV+N+ EEL S E + DN FS
Sbjct: 494 SPVLKTLERSAARKMPSKSLEDISSDSSNQAKVDNQPEELVRSAEDVSTVPTQPDNPFSH 553
Query: 331 PVRL 334
P +L
Sbjct: 554 PDKL 557
>gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens]
Length = 934
Score = 33.1 bits (74), Expect = 1.1
Identities = 22/64 (34%), Positives = 32/64 (50%), Gaps = 7/64 (10%)
Query: 278 SPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESI-------DNSFSS 330
SP +T +RS + S SL +++ KV+N+ EEL S E + DN FS
Sbjct: 493 SPVLKTLERSAARKMPSKSLEDISSDSSNQAKVDNQPEELVRSAEDVSTVPTQPDNPFSH 552
Query: 331 PVRL 334
P +L
Sbjct: 553 PDKL 556
>gi|46255064 synaptotagmin-like 2 isoform d [Homo sapiens]
Length = 1256
Score = 33.1 bits (74), Expect = 1.1
Identities = 22/64 (34%), Positives = 32/64 (50%), Gaps = 7/64 (10%)
Query: 278 SPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESI-------DNSFSS 330
SP +T +RS + S SL +++ KV+N+ EEL S E + DN FS
Sbjct: 815 SPVLKTLERSAARKMPSKSLEDISSDSSNQAKVDNQPEELVRSAEDVSTVPTQPDNPFSH 874
Query: 331 PVRL 334
P +L
Sbjct: 875 PDKL 878
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 33.1 bits (74), Expect = 1.1
Identities = 32/149 (21%), Positives = 65/149 (43%), Gaps = 25/149 (16%)
Query: 229 GAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSK 288
GA S+ + ++ +R + K+R R+L + + + ++ H S
Sbjct: 1159 GATSAQIEMNKKREAEFQKMR--------------RDLEESTLQHEATAAALRKKHADSV 1204
Query: 289 SDATASISLSSNLKRTASNPKVENEDE--ELSSSTESIDNSFSSPVRLAPEREFIKSLMA 346
++ I +K+ K E + E +L+S+ E++ + + F K
Sbjct: 1205 AELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKA---------KANFEKMCRT 1255
Query: 347 IGKRLATLPTKEQKTQRLISELSLLNHKL 375
+ +L+ + TKE++ QRLI+ELS +L
Sbjct: 1256 LEDQLSEIKTKEEEQQRLINELSAQKARL 1284
>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
Length = 2968
Score = 32.3 bits (72), Expect = 1.8
Identities = 28/93 (30%), Positives = 40/93 (43%), Gaps = 6/93 (6%)
Query: 268 SLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNS 327
S S + + S S + S S +++S S SS+ ++S+ + SSST D+S
Sbjct: 2619 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSS 2678
Query: 328 FSSPVRLAPEREFIKSLMAIGKRLATLPTKEQK 360
SS AP S A LPTK K
Sbjct: 2679 CSSDDEAAPAPTAGPSAQA------ALPTKATK 2705
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 32.3 bits (72), Expect = 1.8
Identities = 21/68 (30%), Positives = 33/68 (48%), Gaps = 5/68 (7%)
Query: 415 VLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDND---DEAW 471
+L E+FD +P R+PE +R SV+NL G+ G S + + D D +
Sbjct: 548 ILSSESFDQLDLPERLPEPPLRGCVSVDNL--TGLEEPPSEGPGSCLRRWRQDPLGDSCF 605
Query: 472 SVDDIGEL 479
S+ D E+
Sbjct: 606 SLTDCQEV 613
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,386,560
Number of Sequences: 37866
Number of extensions: 1433077
Number of successful extensions: 5585
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 50
Number of HSP's that attempted gapping in prelim test: 5492
Number of HSP's gapped (non-prelim): 128
length of query: 828
length of database: 18,247,518
effective HSP length: 111
effective length of query: 717
effective length of database: 14,044,392
effective search space: 10069829064
effective search space used: 10069829064
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.