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Search of human proteins with 4505677
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505677 phosphodiesterase 1B [Homo sapiens]
(536 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505677 phosphodiesterase 1B [Homo sapiens] 1075 0.0
gi|4826894 phosphodiesterase 1C [Homo sapiens] 621 e-178
gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens] 618 e-177
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens] 615 e-176
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 238 1e-62
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 238 1e-62
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 238 1e-62
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 234 2e-61
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 234 2e-61
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens] 233 3e-61
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens] 233 3e-61
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens] 233 3e-61
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens] 233 3e-61
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 231 1e-60
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 231 1e-60
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 231 1e-60
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 231 1e-60
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens] 175 1e-43
gi|9506959 phosphodiesterase 7B [Homo sapiens] 174 2e-43
gi|70608155 phosphodiesterase 3A [Homo sapiens] 169 4e-42
gi|40254434 phosphodiesterase 3B [Homo sapiens] 167 2e-41
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens] 165 1e-40
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens] 165 1e-40
gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens] 162 7e-40
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 152 1e-36
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 152 1e-36
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens] 152 1e-36
gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens] 152 1e-36
gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens] 152 1e-36
gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens] 152 1e-36
>gi|4505677 phosphodiesterase 1B [Homo sapiens]
Length = 536
Score = 1075 bits (2780), Expect = 0.0
Identities = 536/536 (100%), Positives = 536/536 (100%)
Query: 1 MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNL 60
MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNL
Sbjct: 1 MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNL 60
Query: 61 EYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKP 120
EYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKP
Sbjct: 61 EYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKP 120
Query: 121 KFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHAL 180
KFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHAL
Sbjct: 121 KFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHAL 180
Query: 181 RTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLL 240
RTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLL
Sbjct: 181 RTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLL 240
Query: 241 RTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSV 300
RTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSV
Sbjct: 241 RTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSV 300
Query: 301 FRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPK 360
FRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPK
Sbjct: 301 FRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPK 360
Query: 361 ALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQS 420
ALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQS
Sbjct: 361 ALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQS 420
Query: 421 QIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVS 480
QIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVS
Sbjct: 421 QIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVS 480
Query: 481 FRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD 536
FRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD
Sbjct: 481 FRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD 536
>gi|4826894 phosphodiesterase 1C [Homo sapiens]
Length = 634
Score = 621 bits (1601), Expect = e-178
Identities = 312/522 (59%), Positives = 400/522 (76%), Gaps = 29/522 (5%)
Query: 7 SPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRY---------MVKQLENGEINIEELK 57
SP + +EE + S L+ +K+W++LR L +Y +VKQLE GE ++ +LK
Sbjct: 3 SPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVDLK 62
Query: 58 KNLEYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAE 117
KNLEY A++LE+VYIDETR++LDTEDEL +++SDAVPSEVRDWLASTFT+Q RR++
Sbjct: 63 KNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSD 122
Query: 118 EKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADD 177
EKP+F+SIVHAVQAGIFVERM+RRT VG +Y AV+ LK++D W FDVFSLN+A+ D
Sbjct: 123 EKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEASGD 182
Query: 178 HALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHC 237
HAL+ I +ELLTR++LISRFKIP L+SF++ALE GY K+KNPYHN +HAADVTQTVH
Sbjct: 183 HALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHY 242
Query: 238 FLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHI 297
L +TG+ + L+E+E+ AIIF+AAIHDYEHTGTTN+FHIQT+S+ AI+YNDRSVLENHH+
Sbjct: 243 LLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHL 302
Query: 298 SSVFRLMQDD-EMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERI 356
S+ +RL+QDD EMNI INL+KD++ E R LVIEMV+ATDMSCHFQQ+K MKTALQQ E I
Sbjct: 303 SAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAI 362
Query: 357 DKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTL 416
+KPKALSL+LH ADISHP K W +H RWT +L+EEFFRQGD+EAELGLPFSPLCDR ST+
Sbjct: 363 EKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTM 422
Query: 417 VAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKS-------------------KNQ 457
VAQSQ+GFIDFIVEPTF+VLTD+ EK V PL DE S++ ++
Sbjct: 423 VAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISSSDAKRSG 482
Query: 458 PSFQWRQPSLDVEVGDPNPDVVSFRSTWVKRIQENKQKWKER 499
+ S + + D SF++TW + + N+++W+ +
Sbjct: 483 VKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAK 524
>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
Length = 545
Score = 618 bits (1593), Expect = e-177
Identities = 307/515 (59%), Positives = 398/515 (77%), Gaps = 23/515 (4%)
Query: 12 LEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNLEYTASLLEAVY 71
+EE + + L ++KMW +L+ +LR +VKQLE G++N+ +LKKN+EY AS+LEAVY
Sbjct: 8 IEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVY 67
Query: 72 IDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPKFRSIVHAVQA 131
IDETR++LDTEDEL ++++D+VPSEVRDWLASTFT++ ++ EEKPKFRSIVHAVQA
Sbjct: 68 IDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQA 127
Query: 132 GIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRH 191
GIFVERM+R+TY VG Y AV+ LK++D W FDVF+LN+A+ +H+L+ +++EL TR+
Sbjct: 128 GIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRY 187
Query: 192 NLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEI 251
+LI+RFKIP L++F +ALE GY KYKNPYHN IHAADVTQTVH +L TG++H L+E+
Sbjct: 188 DLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTEL 247
Query: 252 ELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNI 311
E+LA++FAAAIHDYEHTGTTN+FHIQT+S+ AI+YNDRSVLENHH+S+ +RLMQ++EMNI
Sbjct: 248 EILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNI 307
Query: 312 FINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSLLLHAADI 371
INL+KD++ +LR LVIEMVL+TDMS HFQQ+K ++ +LQQ E ID+ K +SL+LHAADI
Sbjct: 308 LINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADI 367
Query: 372 SHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEP 431
SHP K W +H RWT ALMEEFF QGDKEAELGLPFSPLCDR ST+VAQSQIGFIDFIVEP
Sbjct: 368 SHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEP 427
Query: 432 TFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSL----------------DVEVGDPN 475
TFS+LTD EK V PL +E SK++ ++ + G +
Sbjct: 428 TFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYS 487
Query: 476 P-------DVVSFRSTWVKRIQENKQKWKERAASG 503
P D+ SF++ V IQ+NK++WKE AA G
Sbjct: 488 PDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQG 522
>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
Length = 535
Score = 615 bits (1587), Expect = e-176
Identities = 306/513 (59%), Positives = 397/513 (77%), Gaps = 23/513 (4%)
Query: 12 LEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNLEYTASLLEAVY 71
+EE + + L ++KMW +L+ +LR +VKQLE G++N+ +LKKN+EY AS+LEAVY
Sbjct: 8 IEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVY 67
Query: 72 IDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPKFRSIVHAVQA 131
IDETR++LDTEDEL ++++D+VPSEVRDWLASTFT++ ++ EEKPKFRSIVHAVQA
Sbjct: 68 IDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQA 127
Query: 132 GIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRH 191
GIFVERM+R+TY VG Y AV+ LK++D W FDVF+LN+A+ +H+L+ +++EL TR+
Sbjct: 128 GIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRY 187
Query: 192 NLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEI 251
+LI+RFKIP L++F +ALE GY KYKNPYHN IHAADVTQTVH +L TG++H L+E+
Sbjct: 188 DLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTEL 247
Query: 252 ELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNI 311
E+LA++FAAAIHDYEHTGTTN+FHIQT+S+ AI+YNDRSVLENHH+S+ +RLMQ++EMNI
Sbjct: 248 EILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNI 307
Query: 312 FINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSLLLHAADI 371
INL+KD++ +LR LVIEMVL+TDMS HFQQ+K ++ +LQQ E ID+ K +SL+LHAADI
Sbjct: 308 LINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADI 367
Query: 372 SHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEP 431
SHP K W +H RWT ALMEEFF QGDKEAELGLPFSPLCDR ST+VAQSQIGFIDFIVEP
Sbjct: 368 SHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEP 427
Query: 432 TFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSL----------------DVEVGDPN 475
TFS+LTD EK V PL +E SK++ ++ + G +
Sbjct: 428 TFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYS 487
Query: 476 P-------DVVSFRSTWVKRIQENKQKWKERAA 501
P D+ SF++ V IQ+NK++WKE AA
Sbjct: 488 PDYSLAAVDLKSFKNNLVDIIQQNKERWKELAA 520
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 238 bits (607), Expect = 1e-62
Identities = 134/383 (34%), Positives = 213/383 (55%), Gaps = 16/383 (4%)
Query: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
L++ + W DVF + + + + L I+F + +L+ F+IP L ++L LE G+
Sbjct: 218 LEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLE-GHYH 276
Query: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
YHN +HAADV Q+ H L + +++E+LA +FA+AIHD +H G +N F I
Sbjct: 277 ANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLIN 336
Query: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
T SE A++YND SVLENHH++ F+L+Q + +IF NL+ + + LR +VI+MVLATDMS
Sbjct: 337 TNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMS 396
Query: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
H + +KT ++ + D+ + L L+H AD+S+PTK ++ +WT
Sbjct: 397 KHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTD 456
Query: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
+M EFF+QGD+E E GL SP+CD+ + V +SQ+GFID+I P + D+ Q
Sbjct: 457 RIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQD 516
Query: 447 LAD--EDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFRSTWVKRIQENKQKWKERAASGI 504
L D ED++ Q R PS PD F T + +E++++ +E + +
Sbjct: 517 LLDTLEDNREWYQSKIP-RSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETAL 575
Query: 505 TNQ-MSIDELSPCEEEAPPSPAE 526
+ + + + EA P P +
Sbjct: 576 AKEALELPDTELLSPEAGPDPGD 598
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 238 bits (607), Expect = 1e-62
Identities = 134/383 (34%), Positives = 213/383 (55%), Gaps = 16/383 (4%)
Query: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
L++ + W DVF + + + + L I+F + +L+ F+IP L ++L LE G+
Sbjct: 292 LEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLE-GHYH 350
Query: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
YHN +HAADV Q+ H L + +++E+LA +FA+AIHD +H G +N F I
Sbjct: 351 ANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLIN 410
Query: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
T SE A++YND SVLENHH++ F+L+Q + +IF NL+ + + LR +VI+MVLATDMS
Sbjct: 411 TNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMS 470
Query: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
H + +KT ++ + D+ + L L+H AD+S+PTK ++ +WT
Sbjct: 471 KHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTD 530
Query: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
+M EFF+QGD+E E GL SP+CD+ + V +SQ+GFID+I P + D+ Q
Sbjct: 531 RIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQD 590
Query: 447 LAD--EDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFRSTWVKRIQENKQKWKERAASGI 504
L D ED++ Q R PS PD F T + +E++++ +E + +
Sbjct: 591 LLDTLEDNREWYQSKIP-RSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETAL 649
Query: 505 TNQ-MSIDELSPCEEEAPPSPAE 526
+ + + + EA P P +
Sbjct: 650 AKEALELPDTELLSPEAGPDPGD 672
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 238 bits (607), Expect = 1e-62
Identities = 134/383 (34%), Positives = 213/383 (55%), Gaps = 16/383 (4%)
Query: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
L++ + W DVF + + + + L I+F + +L+ F+IP L ++L LE G+
Sbjct: 324 LEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLE-GHYH 382
Query: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
YHN +HAADV Q+ H L + +++E+LA +FA+AIHD +H G +N F I
Sbjct: 383 ANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLIN 442
Query: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
T SE A++YND SVLENHH++ F+L+Q + +IF NL+ + + LR +VI+MVLATDMS
Sbjct: 443 TNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMS 502
Query: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
H + +KT ++ + D+ + L L+H AD+S+PTK ++ +WT
Sbjct: 503 KHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTD 562
Query: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
+M EFF+QGD+E E GL SP+CD+ + V +SQ+GFID+I P + D+ Q
Sbjct: 563 RIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQD 622
Query: 447 LAD--EDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFRSTWVKRIQENKQKWKERAASGI 504
L D ED++ Q R PS PD F T + +E++++ +E + +
Sbjct: 623 LLDTLEDNREWYQSKIP-RSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETAL 681
Query: 505 TNQ-MSIDELSPCEEEAPPSPAE 526
+ + + + EA P P +
Sbjct: 682 AKEALELPDTELLSPEAGPDPGD 704
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 234 bits (596), Expect = 2e-61
Identities = 127/333 (38%), Positives = 196/333 (58%), Gaps = 22/333 (6%)
Query: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
L++++ W VF + + + + L I+ + +L+ FKIP L+++L LE Y
Sbjct: 398 LEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHA 457
Query: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
YHN IHAADV Q+ H L + +++E+LA IFA+AIHD +H G +N F I
Sbjct: 458 -DVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLIN 516
Query: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
T SE A++YND SVLENHH++ F+L+Q++ +IF NLTK + LR +VI++VLATDMS
Sbjct: 517 TNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMS 576
Query: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
H + +KT ++ + D+ + L ++H AD+S+PTK ++ +WT
Sbjct: 577 KHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTD 636
Query: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
+MEEFFRQGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D+ Q
Sbjct: 637 RIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQD 696
Query: 447 LAD--EDSKSKNQPSFQWRQPSLDVEVGDPNPD 477
+ D ED++ +W Q ++ + P PD
Sbjct: 697 ILDTLEDNR-------EWYQSTIP-QSPSPAPD 721
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 234 bits (596), Expect = 2e-61
Identities = 127/333 (38%), Positives = 196/333 (58%), Gaps = 22/333 (6%)
Query: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
L++++ W VF + + + + L I+ + +L+ FKIP L+++L LE Y
Sbjct: 262 LEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHA 321
Query: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
YHN IHAADV Q+ H L + +++E+LA IFA+AIHD +H G +N F I
Sbjct: 322 -DVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLIN 380
Query: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
T SE A++YND SVLENHH++ F+L+Q++ +IF NLTK + LR +VI++VLATDMS
Sbjct: 381 TNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMS 440
Query: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
H + +KT ++ + D+ + L ++H AD+S+PTK ++ +WT
Sbjct: 441 KHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTD 500
Query: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
+MEEFFRQGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D+ Q
Sbjct: 501 RIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQD 560
Query: 447 LAD--EDSKSKNQPSFQWRQPSLDVEVGDPNPD 477
+ D ED++ +W Q ++ + P PD
Sbjct: 561 ILDTLEDNR-------EWYQSTIP-QSPSPAPD 585
>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 233 bits (594), Expect = 3e-61
Identities = 125/330 (37%), Positives = 198/330 (60%), Gaps = 15/330 (4%)
Query: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
L++L+ W ++F++ + + L I++ + +L+ F+I + ++++ LE Y
Sbjct: 342 LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHS 401
Query: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
YHN +HAADV Q+ H L + +++E+LA IFAAAIHD +H G +N F I
Sbjct: 402 -DVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLIN 460
Query: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
T SE A++YND SVLENHH++ F+L+Q++ +IF+NLTK + LR +VI+MVLATDMS
Sbjct: 461 TNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMS 520
Query: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
H + +KT ++ + D+ + L ++H AD+S+PTK ++ +WT
Sbjct: 521 KHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTD 580
Query: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
+MEEFF+QGDKE E G+ SP+CD+ + V +SQ+GFID+IV P + D+ + Q
Sbjct: 581 RIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQD 640
Query: 447 LAD--EDSKSKNQPSF-QWRQPSLDVEVGD 473
+ D ED+++ Q Q P LD + D
Sbjct: 641 ILDTLEDNRNWYQSMIPQSPSPPLDEQNRD 670
>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
Length = 721
Score = 233 bits (594), Expect = 3e-61
Identities = 125/330 (37%), Positives = 198/330 (60%), Gaps = 15/330 (4%)
Query: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
L++L+ W ++F++ + + L I++ + +L+ F+I + ++++ LE Y
Sbjct: 327 LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHS 386
Query: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
YHN +HAADV Q+ H L + +++E+LA IFAAAIHD +H G +N F I
Sbjct: 387 -DVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLIN 445
Query: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
T SE A++YND SVLENHH++ F+L+Q++ +IF+NLTK + LR +VI+MVLATDMS
Sbjct: 446 TNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMS 505
Query: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
H + +KT ++ + D+ + L ++H AD+S+PTK ++ +WT
Sbjct: 506 KHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTD 565
Query: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
+MEEFF+QGDKE E G+ SP+CD+ + V +SQ+GFID+IV P + D+ + Q
Sbjct: 566 RIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQD 625
Query: 447 LAD--EDSKSKNQPSF-QWRQPSLDVEVGD 473
+ D ED+++ Q Q P LD + D
Sbjct: 626 ILDTLEDNRNWYQSMIPQSPSPPLDEQNRD 655
>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
Length = 564
Score = 233 bits (594), Expect = 3e-61
Identities = 125/330 (37%), Positives = 198/330 (60%), Gaps = 15/330 (4%)
Query: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
L++L+ W ++F++ + + L I++ + +L+ F+I + ++++ LE Y
Sbjct: 170 LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHS 229
Query: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
YHN +HAADV Q+ H L + +++E+LA IFAAAIHD +H G +N F I
Sbjct: 230 -DVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLIN 288
Query: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
T SE A++YND SVLENHH++ F+L+Q++ +IF+NLTK + LR +VI+MVLATDMS
Sbjct: 289 TNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMS 348
Query: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
H + +KT ++ + D+ + L ++H AD+S+PTK ++ +WT
Sbjct: 349 KHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTD 408
Query: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
+MEEFF+QGDKE E G+ SP+CD+ + V +SQ+GFID+IV P + D+ + Q
Sbjct: 409 RIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQD 468
Query: 447 LAD--EDSKSKNQPSF-QWRQPSLDVEVGD 473
+ D ED+++ Q Q P LD + D
Sbjct: 469 ILDTLEDNRNWYQSMIPQSPSPPLDEQNRD 498
>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 233 bits (594), Expect = 3e-61
Identities = 125/330 (37%), Positives = 198/330 (60%), Gaps = 15/330 (4%)
Query: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
L++L+ W ++F++ + + L I++ + +L+ F+I + ++++ LE Y
Sbjct: 342 LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHS 401
Query: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
YHN +HAADV Q+ H L + +++E+LA IFAAAIHD +H G +N F I
Sbjct: 402 -DVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLIN 460
Query: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
T SE A++YND SVLENHH++ F+L+Q++ +IF+NLTK + LR +VI+MVLATDMS
Sbjct: 461 TNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMS 520
Query: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
H + +KT ++ + D+ + L ++H AD+S+PTK ++ +WT
Sbjct: 521 KHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTD 580
Query: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
+MEEFF+QGDKE E G+ SP+CD+ + V +SQ+GFID+IV P + D+ + Q
Sbjct: 581 RIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQD 640
Query: 447 LAD--EDSKSKNQPSF-QWRQPSLDVEVGD 473
+ D ED+++ Q Q P LD + D
Sbjct: 641 ILDTLEDNRNWYQSMIPQSPSPPLDEQNRD 670
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 231 bits (590), Expect = 1e-60
Identities = 119/309 (38%), Positives = 189/309 (61%), Gaps = 14/309 (4%)
Query: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
L+NL+ W ++F ++ A +L I++ + +L+ +F+IP +++++ LE Y
Sbjct: 308 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 367
Query: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
YHN +HAADV Q+ H L + +++E+LA +FAAAIHD +H G +N F I
Sbjct: 368 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 426
Query: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
T SE A++YND SVLENHH++ F+L+Q+D +IF NL+K + LR +VI+MVLATDMS
Sbjct: 427 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 486
Query: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
H + +KT ++ + D+ + L ++H AD+S+PTK ++ +WT
Sbjct: 487 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 546
Query: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
+M EFF+QGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D+ Q
Sbjct: 547 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQE 606
Query: 447 LAD--EDSK 453
+ D ED++
Sbjct: 607 ILDTLEDNR 615
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 231 bits (590), Expect = 1e-60
Identities = 119/309 (38%), Positives = 189/309 (61%), Gaps = 14/309 (4%)
Query: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
L+NL+ W ++F ++ A +L I++ + +L+ +F+IP +++++ LE Y
Sbjct: 343 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 402
Query: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
YHN +HAADV Q+ H L + +++E+LA +FAAAIHD +H G +N F I
Sbjct: 403 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 461
Query: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
T SE A++YND SVLENHH++ F+L+Q+D +IF NL+K + LR +VI+MVLATDMS
Sbjct: 462 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 521
Query: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
H + +KT ++ + D+ + L ++H AD+S+PTK ++ +WT
Sbjct: 522 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 581
Query: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
+M EFF+QGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D+ Q
Sbjct: 582 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQE 641
Query: 447 LAD--EDSK 453
+ D ED++
Sbjct: 642 ILDTLEDNR 650
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 231 bits (590), Expect = 1e-60
Identities = 119/309 (38%), Positives = 189/309 (61%), Gaps = 14/309 (4%)
Query: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
L+NL+ W ++F ++ A +L I++ + +L+ +F+IP +++++ LE Y
Sbjct: 369 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 428
Query: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
YHN +HAADV Q+ H L + +++E+LA +FAAAIHD +H G +N F I
Sbjct: 429 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 487
Query: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
T SE A++YND SVLENHH++ F+L+Q+D +IF NL+K + LR +VI+MVLATDMS
Sbjct: 488 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 547
Query: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
H + +KT ++ + D+ + L ++H AD+S+PTK ++ +WT
Sbjct: 548 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 607
Query: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
+M EFF+QGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D+ Q
Sbjct: 608 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQE 667
Query: 447 LAD--EDSK 453
+ D ED++
Sbjct: 668 ILDTLEDNR 676
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 231 bits (590), Expect = 1e-60
Identities = 119/309 (38%), Positives = 189/309 (61%), Gaps = 14/309 (4%)
Query: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
L+NL+ W ++F ++ A +L I++ + +L+ +F+IP +++++ LE Y
Sbjct: 130 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 189
Query: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
YHN +HAADV Q+ H L + +++E+LA +FAAAIHD +H G +N F I
Sbjct: 190 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 248
Query: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
T SE A++YND SVLENHH++ F+L+Q+D +IF NL+K + LR +VI+MVLATDMS
Sbjct: 249 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 308
Query: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
H + +KT ++ + D+ + L ++H AD+S+PTK ++ +WT
Sbjct: 309 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 368
Query: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
+M EFF+QGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D+ Q
Sbjct: 369 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQE 428
Query: 447 LAD--EDSK 453
+ D ED++
Sbjct: 429 ILDTLEDNR 437
>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
Length = 456
Score = 175 bits (443), Expect = 1e-43
Identities = 100/308 (32%), Positives = 165/308 (53%), Gaps = 13/308 (4%)
Query: 137 RMFRRTYTS-----VGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRH 191
R FR T S + Y+ L+ + W FD+F ++ + ++L ++ F L + H
Sbjct: 96 RFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLH 155
Query: 192 NLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEI 251
LI F + + L FL ++ Y +NPYHN +HAADVTQ +HC+L + + ++
Sbjct: 156 GLIEYFHLDMMKLRRFLVMIQEDYHS-QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW 214
Query: 252 ELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNI 311
++L + AAA HD +H G F I+T A +Y + SVLENHH S L++ E +
Sbjct: 215 DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLR--ESGL 272
Query: 312 FINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQ-----LERIDKPKALSLLL 366
F +L + ++ + ++LATD+S + + ++ L + + + L + L
Sbjct: 273 FSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMAL 332
Query: 367 HAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFID 426
ADI +P + W + +W++ + EEFF QGD E + L SPLCDR + +A QIGF+
Sbjct: 333 KCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMT 392
Query: 427 FIVEPTFS 434
++VEP F+
Sbjct: 393 YLVEPLFT 400
>gi|9506959 phosphodiesterase 7B [Homo sapiens]
Length = 450
Score = 174 bits (441), Expect = 2e-43
Identities = 93/281 (33%), Positives = 155/281 (55%), Gaps = 8/281 (2%)
Query: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
L + +W FD+F ++ + ++L T++ L H LI FK+ V L FL ++ Y
Sbjct: 109 LSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHS 168
Query: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
+NPYHN +HAADVTQ +HC+L + L+ ++++ + AAA HD +H G F I+
Sbjct: 169 -QNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIK 227
Query: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
T A +Y + SVLENHH S +++ E + +L K+ ++ + ++LATD++
Sbjct: 228 TNHHLANLYQNMSVLENHHWRSTIGMLR--ESRLLAHLPKEMTQDIEQQLGSLILATDIN 285
Query: 338 CHFQQVKTMKTALQQL-----ERIDKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEF 392
+ + +K L + D+ L + L ADI +P + W + +W++ + EEF
Sbjct: 286 RQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEF 345
Query: 393 FRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTF 433
+RQG+ E + L SPLC++ + QIGF+ +IVEP F
Sbjct: 346 YRQGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLF 386
>gi|70608155 phosphodiesterase 3A [Homo sapiens]
Length = 1141
Score = 169 bits (429), Expect = 4e-42
Identities = 132/446 (29%), Positives = 199/446 (44%), Gaps = 74/446 (16%)
Query: 158 LKNLDLWCFDVFSLNQAAD---DHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETG 214
++ L+ W F +F L + L + + L L FKIP M++ ALE G
Sbjct: 686 MEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIG 745
Query: 215 YGKYKNPYHNQIHAADVTQTVHCFLLR---------------------TGMVH------- 246
Y PYHN+IHA DV V + +G H
Sbjct: 746 YRDI--PYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVF 803
Query: 247 ------------CLS----EIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRS 290
CLS +EL+A+ AAA+HDY+H G TN+F + T + A++YNDRS
Sbjct: 804 SKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRS 863
Query: 291 VLENHHISSVFRL-MQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMK-- 347
VLENHH ++ + L M E N INL EF R LVIE +LATD+ HF V
Sbjct: 864 VLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGK 923
Query: 348 ----TALQQLERIDKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELG 403
+ D+ + + ADI+ P K +H +WT ++ EF+ QGD+EA LG
Sbjct: 924 VNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLG 983
Query: 404 LPFSPLCDRTSTLVAQSQIGFIDFIVEP---TFSVLTDVAEKSVQPLADEDSKSKNQPSF 460
LP SP DR++ +A Q FI IV P ++ + K V+ +DE + +
Sbjct: 984 LPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVED-SDESGDTDDPEEE 1042
Query: 461 QWRQPSLDVE---VGDPNPDVVSFRSTWV-----KRIQENKQKWK-----ERAASGITNQ 507
+ P+ + E + +P +F+ + + + +N + WK E+ +GI NQ
Sbjct: 1043 EEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQ 1102
Query: 508 MSIDELSPCEEEAPPSPAEDEHNQNG 533
S+D+ ++E + G
Sbjct: 1103 -SLDQTPQSHSSEQIQAIKEEEEEKG 1127
>gi|40254434 phosphodiesterase 3B [Homo sapiens]
Length = 1112
Score = 167 bits (424), Expect = 2e-41
Identities = 110/330 (33%), Positives = 160/330 (48%), Gaps = 58/330 (17%)
Query: 158 LKNLDLWCFDVFSLNQAADDHA---LRTIVFELLTRHNLISRFKIPTVFLMSFLDALETG 214
++ + W F +F L + + + L +++ L L+ FKIPT M++ ALE G
Sbjct: 671 IEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENG 730
Query: 215 YGKYKNPYHNQIHAADVTQTVHCFLLRT--------------------GMVH-------- 246
Y PYHN+IHA DV V R G ++
Sbjct: 731 YRDI--PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYIS 788
Query: 247 ------------CLSE----IELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRS 290
CLS +EL+A+ AAA+HDY+H G TN+F + T + A++YNDRS
Sbjct: 789 SKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRS 848
Query: 291 VLENHHISSVFRL-MQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTM--- 346
VLENHH +S + L + E N ++L EF R LVIE +LATD+ HF +
Sbjct: 849 VLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAK 908
Query: 347 -----KTALQQLERIDKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAE 401
++ D+ + + ADI+ P K +H +WT+ ++ EF+ QGD+EA
Sbjct: 909 ANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEAN 968
Query: 402 LGLPFSPLCDRTSTLVAQSQIGFIDFIVEP 431
LGLP SP DR+S +A+ Q FI IV P
Sbjct: 969 LGLPISPFMDRSSPQLAKLQESFITHIVGP 998
>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
Length = 783
Score = 165 bits (417), Expect = 1e-40
Identities = 99/304 (32%), Positives = 154/304 (50%), Gaps = 25/304 (8%)
Query: 154 VLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALET 213
+ ++N + W FD+F L A + L + ++ R + L S+L +E
Sbjct: 442 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 501
Query: 214 GYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNS 273
Y NPYHN H+ADV FL + + L I+ +A + AA IHD +H G TNS
Sbjct: 502 NYHS-SNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNS 560
Query: 274 FHIQTKSECAIVYNDRSVLENHHISSVFRLMQ-DDEMNIFINLTKDEFVELRALVIEMVL 332
F SE AI+YND +VLE+HH + F+L DD+ NIF N+ ++++ LR +I+MVL
Sbjct: 561 FLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVL 620
Query: 333 ATDMSCHFQQVKTMKTA-------LQQLERIDKPKAL---------------SLLLHAAD 370
AT+M+ HF+ V + L++ DK + + +L+ AD
Sbjct: 621 ATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCAD 680
Query: 371 ISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLP-FSPLCDRTSTLVAQSQIGFIDFIV 429
+S+P + W + EE+F Q D+E + GLP P+ DR + + +SQI FID+ +
Sbjct: 681 VSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFI 740
Query: 430 EPTF 433
F
Sbjct: 741 TDMF 744
>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
Length = 829
Score = 165 bits (417), Expect = 1e-40
Identities = 99/304 (32%), Positives = 154/304 (50%), Gaps = 25/304 (8%)
Query: 154 VLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALET 213
+ ++N + W FD+F L A + L + ++ R + L S+L +E
Sbjct: 488 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 547
Query: 214 GYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNS 273
Y NPYHN H+ADV FL + + L I+ +A + AA IHD +H G TNS
Sbjct: 548 NYHS-SNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNS 606
Query: 274 FHIQTKSECAIVYNDRSVLENHHISSVFRLMQ-DDEMNIFINLTKDEFVELRALVIEMVL 332
F SE AI+YND +VLE+HH + F+L DD+ NIF N+ ++++ LR +I+MVL
Sbjct: 607 FLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVL 666
Query: 333 ATDMSCHFQQVKTMKTA-------LQQLERIDKPKAL---------------SLLLHAAD 370
AT+M+ HF+ V + L++ DK + + +L+ AD
Sbjct: 667 ATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCAD 726
Query: 371 ISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLP-FSPLCDRTSTLVAQSQIGFIDFIV 429
+S+P + W + EE+F Q D+E + GLP P+ DR + + +SQI FID+ +
Sbjct: 727 VSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFI 786
Query: 430 EPTF 433
F
Sbjct: 787 TDMF 790
>gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]
Length = 424
Score = 162 bits (410), Expect = 7e-40
Identities = 95/297 (31%), Positives = 156/297 (52%), Gaps = 13/297 (4%)
Query: 137 RMFRRTYTS-----VGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRH 191
R FR T S + Y+ L+ + W FD+F ++ + ++L ++ F L + H
Sbjct: 122 RFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLH 181
Query: 192 NLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEI 251
LI F + + L FL ++ Y +NPYHN +HAADVTQ +HC+L + + ++
Sbjct: 182 GLIEYFHLDMMKLRRFLVMIQEDYHS-QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW 240
Query: 252 ELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNI 311
++L + AAA HD +H G F I+T A +Y + SVLENHH S L++ E +
Sbjct: 241 DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLR--ESGL 298
Query: 312 FINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQ-----LERIDKPKALSLLL 366
F +L + ++ + ++LATD+S + + ++ L + + + L + L
Sbjct: 299 FSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMAL 358
Query: 367 HAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIG 423
ADI +P + W + +W++ + EEFF QGD E + L SPLCDR + +A QIG
Sbjct: 359 KCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIG 415
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 152 bits (383), Expect = 1e-36
Identities = 87/262 (33%), Positives = 138/262 (52%), Gaps = 9/262 (3%)
Query: 193 LISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIE 252
L+ F I V L +L + Y NP+HN H V Q ++ + + S+ +
Sbjct: 77 LVRDFSINPVTLRRWLFCVHDNYRN--NPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTD 134
Query: 253 LLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIF 312
+L ++ AA HD +H G N++ I ++E A+ YND S LENHH + F+++ + E NIF
Sbjct: 135 ILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIF 194
Query: 313 INLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSL---LLHAA 369
N+ D F ++R +I ++LATDM+ H + + + K ++ + ++ L L+
Sbjct: 195 SNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCC 254
Query: 370 DISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIV 429
DIS+ + V W L+EE+F Q D+E GLP +P DR A +QIGFI F++
Sbjct: 255 DISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVL 314
Query: 430 EPTFSVLTD----VAEKSVQPL 447
P F +T V E +QPL
Sbjct: 315 IPMFETVTKLFPMVEEIMLQPL 336
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 152 bits (383), Expect = 1e-36
Identities = 87/262 (33%), Positives = 138/262 (52%), Gaps = 9/262 (3%)
Query: 193 LISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIE 252
L+ F I V L +L + Y NP+HN H V Q ++ + + S+ +
Sbjct: 77 LVRDFSINPVTLRRWLFCVHDNYRN--NPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTD 134
Query: 253 LLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIF 312
+L ++ AA HD +H G N++ I ++E A+ YND S LENHH + F+++ + E NIF
Sbjct: 135 ILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIF 194
Query: 313 INLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSL---LLHAA 369
N+ D F ++R +I ++LATDM+ H + + + K ++ + ++ L L+
Sbjct: 195 SNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCC 254
Query: 370 DISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIV 429
DIS+ + V W L+EE+F Q D+E GLP +P DR A +QIGFI F++
Sbjct: 255 DISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVL 314
Query: 430 EPTFSVLTD----VAEKSVQPL 447
P F +T V E +QPL
Sbjct: 315 IPMFETVTKLFPMVEEIMLQPL 336
>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
Length = 567
Score = 152 bits (383), Expect = 1e-36
Identities = 87/262 (33%), Positives = 138/262 (52%), Gaps = 9/262 (3%)
Query: 193 LISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIE 252
L+ F I V L +L + Y NP+HN H V Q ++ + + S+ +
Sbjct: 258 LVRDFSINPVTLRRWLFCVHDNYRN--NPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTD 315
Query: 253 LLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIF 312
+L ++ AA HD +H G N++ I ++E A+ YND S LENHH + F+++ + E NIF
Sbjct: 316 ILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIF 375
Query: 313 INLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSL---LLHAA 369
N+ D F ++R +I ++LATDM+ H + + + K ++ + ++ L L+
Sbjct: 376 SNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCC 435
Query: 370 DISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIV 429
DIS+ + V W L+EE+F Q D+E GLP +P DR A +QIGFI F++
Sbjct: 436 DISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVL 495
Query: 430 EPTFSVLTD----VAEKSVQPL 447
P F +T V E +QPL
Sbjct: 496 IPMFETVTKLFPMVEEIMLQPL 517
>gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens]
Length = 552
Score = 152 bits (383), Expect = 1e-36
Identities = 87/262 (33%), Positives = 138/262 (52%), Gaps = 9/262 (3%)
Query: 193 LISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIE 252
L+ F I V L +L + Y NP+HN H V Q ++ + + S+ +
Sbjct: 243 LVRDFSINPVTLRRWLFCVHDNYRN--NPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTD 300
Query: 253 LLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIF 312
+L ++ AA HD +H G N++ I ++E A+ YND S LENHH + F+++ + E NIF
Sbjct: 301 ILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIF 360
Query: 313 INLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSL---LLHAA 369
N+ D F ++R +I ++LATDM+ H + + + K ++ + ++ L L+
Sbjct: 361 SNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCC 420
Query: 370 DISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIV 429
DIS+ + V W L+EE+F Q D+E GLP +P DR A +QIGFI F++
Sbjct: 421 DISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVL 480
Query: 430 EPTFSVLTD----VAEKSVQPL 447
P F +T V E +QPL
Sbjct: 481 IPMFETVTKLFPMVEEIMLQPL 502
>gi|48762746 phosphodiesterase 9A isoform m [Homo sapiens]
Length = 526
Score = 152 bits (383), Expect = 1e-36
Identities = 87/262 (33%), Positives = 138/262 (52%), Gaps = 9/262 (3%)
Query: 193 LISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIE 252
L+ F I V L +L + Y NP+HN H V Q ++ + + S+ +
Sbjct: 217 LVRDFSINPVTLRRWLFCVHDNYRN--NPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTD 274
Query: 253 LLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIF 312
+L ++ AA HD +H G N++ I ++E A+ YND S LENHH + F+++ + E NIF
Sbjct: 275 ILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIF 334
Query: 313 INLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSL---LLHAA 369
N+ D F ++R +I ++LATDM+ H + + + K ++ + ++ L L+
Sbjct: 335 SNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCC 394
Query: 370 DISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIV 429
DIS+ + V W L+EE+F Q D+E GLP +P DR A +QIGFI F++
Sbjct: 395 DISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVL 454
Query: 430 EPTFSVLTD----VAEKSVQPL 447
P F +T V E +QPL
Sbjct: 455 IPMFETVTKLFPMVEEIMLQPL 476
>gi|48762744 phosphodiesterase 9A isoform j [Homo sapiens]
Length = 376
Score = 152 bits (383), Expect = 1e-36
Identities = 87/262 (33%), Positives = 138/262 (52%), Gaps = 9/262 (3%)
Query: 193 LISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIE 252
L+ F I V L +L + Y NP+HN H V Q ++ + + S+ +
Sbjct: 67 LVRDFSINPVTLRRWLFCVHDNYRN--NPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTD 124
Query: 253 LLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIF 312
+L ++ AA HD +H G N++ I ++E A+ YND S LENHH + F+++ + E NIF
Sbjct: 125 ILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIF 184
Query: 313 INLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSL---LLHAA 369
N+ D F ++R +I ++LATDM+ H + + + K ++ + ++ L L+
Sbjct: 185 SNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCC 244
Query: 370 DISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIV 429
DIS+ + V W L+EE+F Q D+E GLP +P DR A +QIGFI F++
Sbjct: 245 DISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVL 304
Query: 430 EPTFSVLTD----VAEKSVQPL 447
P F +T V E +QPL
Sbjct: 305 IPMFETVTKLFPMVEEIMLQPL 326
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.132 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,737,575
Number of Sequences: 37866
Number of extensions: 836343
Number of successful extensions: 3125
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 2922
Number of HSP's gapped (non-prelim): 107
length of query: 536
length of database: 18,247,518
effective HSP length: 107
effective length of query: 429
effective length of database: 14,195,856
effective search space: 6090022224
effective search space used: 6090022224
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.