Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 13112048
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13112048 fibroblast growth factor receptor 3 isoform 2
precursor [Homo sapiens]
(694 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 1415 0.0
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 955 0.0
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 825 0.0
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 790 0.0
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 786 0.0
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 784 0.0
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 648 0.0
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 642 0.0
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 642 0.0
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 642 0.0
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 635 0.0
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 635 0.0
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 634 0.0
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 634 0.0
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 598 e-171
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 598 e-171
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 596 e-170
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 549 e-156
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 549 e-156
gi|13186249 fibroblast growth factor receptor 1 isoform 9 precur... 544 e-155
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 328 1e-89
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 328 1e-89
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 324 2e-88
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 314 2e-85
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge... 287 3e-77
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene... 287 3e-77
gi|13186241 fibroblast growth factor receptor 1 isoform 6 precur... 278 9e-75
gi|13186238 fibroblast growth factor receptor 1 isoform 5 precur... 275 1e-73
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap... 249 5e-66
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like... 249 5e-66
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 1415 bits (3664), Expect = 0.0
Identities = 694/694 (100%), Positives = 694/694 (100%)
Query: 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS 60
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS
Sbjct: 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS 60
Query: 61 CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH 120
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH
Sbjct: 61 CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH 120
Query: 121 FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
Sbjct: 121 FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
Query: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
Sbjct: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
Query: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
Sbjct: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
Query: 301 DGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARL 360
DGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARL
Sbjct: 301 DGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARL 360
Query: 361 TLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMI 420
TLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMI
Sbjct: 361 TLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMI 420
Query: 421 GKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFK 480
GKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFK
Sbjct: 421 GKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFK 480
Query: 481 DLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTT 540
DLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTT
Sbjct: 481 DLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTT 540
Query: 541 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHR 600
NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHR
Sbjct: 541 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHR 600
Query: 601 MDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSP 660
MDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSP
Sbjct: 601 MDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSP 660
Query: 661 GGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT 694
GGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
Sbjct: 661 GGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT 694
>gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
Length = 705
Score = 955 bits (2469), Expect = 0.0
Identities = 472/649 (72%), Positives = 538/649 (82%), Gaps = 10/649 (1%)
Query: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Query: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
Query: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
Query: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
PSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYS
Sbjct: 223 PSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYS 282
Query: 280 DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIA-RLSS-GEGP 337
DAQPHIQW+KHVE NGSK GPDG PY+ VLKVS ES++SM+SNTPLVRI RLSS + P
Sbjct: 283 DAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKVSAESSSSMNSNTPLVRITTRLSSTADTP 342
Query: 338 TLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKM 397
LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+ + VTVAVKM
Sbjct: 343 MLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKM 402
Query: 398 LKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRA 457
LKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+LRA
Sbjct: 403 LKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRA 462
Query: 458 RRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDN 517
RRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLAARNVLVTE+N
Sbjct: 463 RRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN 522
Query: 518 VMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFT 577
VMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL+WEIFT
Sbjct: 523 VMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT 582
Query: 578 LGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLD 637
LGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRPTFKQLVEDLD
Sbjct: 583 LGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD 642
Query: 638 RVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 686
R+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D +P P
Sbjct: 643 RILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 691
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 825 bits (2132), Expect = 0.0
Identities = 427/665 (64%), Positives = 499/665 (75%), Gaps = 38/665 (5%)
Query: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Query: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
Query: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
Query: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGS----DVEFHC 275
PSD+GNYTCVVEN++GSI TY LDV+ P + + S ++ +C
Sbjct: 223 PSDKGNYTCVVENEYGSINHTYHLDVVA------------PGREKEITASPDYLEIAIYC 270
Query: 276 KVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLK------------VSLESNASMSSNT 323
+ + + + PD + V K VS ES++SM+SNT
Sbjct: 271 IGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNT 330
Query: 324 PLVRIA-RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIG 381
PLVRI RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+G
Sbjct: 331 PLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVG 390
Query: 382 IDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYV 441
IDKD+ + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV
Sbjct: 391 IDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYV 450
Query: 442 LVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKC 501
+VEYA+KGNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKC
Sbjct: 451 IVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKC 510
Query: 502 IHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTH 561
IHRDLAARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTH
Sbjct: 511 IHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTH 570
Query: 562 QSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHA 621
QSDVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA
Sbjct: 571 QSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHA 630
Query: 622 APSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDL 681
PSQRPTFKQLVEDLDR+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D
Sbjct: 631 VPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDP 690
Query: 682 LPPAP 686
+P P
Sbjct: 691 MPYEP 695
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 790 bits (2039), Expect = 0.0
Identities = 416/543 (76%), Positives = 439/543 (80%), Gaps = 27/543 (4%)
Query: 172 VRFRCPAAGNPTPSISWLKN-----------GREFRGEHRIGGIKLRHQQWSLV-MESVV 219
V F C + P I WLK+ G + + G ++ ++ + +V
Sbjct: 271 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVT 330
Query: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTA-VLGSDVEFHCKVY 278
D G YTC+ N G + L VL +++A + A +L V F +
Sbjct: 331 FEDAGEYTCLAGNSIGFSHHSAWLVVL--PAEEELVEADEAGSVYAGILSYGVGFFLFIL 388
Query: 279 SDAQPHIQWLKHVEVNGSKVGPDGTPYVTVL-------KVSLESNASMSSNTPLVRIARL 331
A + L+ G G+P V + +VSLESNASMSSNTPLVRIARL
Sbjct: 389 VVAAVTLCRLRSPPKKGL-----GSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARL 443
Query: 332 SSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPV 391
SSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPV
Sbjct: 444 SSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPV 503
Query: 392 TVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNL 451
TVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNL
Sbjct: 504 TVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNL 563
Query: 452 REFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNV 511
REFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNV
Sbjct: 564 REFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNV 623
Query: 512 LVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 571
LVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL
Sbjct: 624 LVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 683
Query: 572 LWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQ 631
LWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQ
Sbjct: 684 LWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQ 743
Query: 632 LVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGG 691
LVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGG
Sbjct: 744 LVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGG 803
Query: 692 SRT 694
SRT
Sbjct: 804 SRT 806
Score = 640 bits (1650), Expect = 0.0
Identities = 310/312 (99%), Positives = 311/312 (99%)
Query: 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS 60
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS
Sbjct: 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS 60
Query: 61 CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH 120
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH
Sbjct: 61 CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH 120
Query: 121 FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
Sbjct: 121 FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
Query: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
Sbjct: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
Query: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
Sbjct: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
Query: 301 DGTPYVTVLKVS 312
DGTPYVTVLK +
Sbjct: 301 DGTPYVTVLKTA 312
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 786 bits (2029), Expect = 0.0
Identities = 418/550 (76%), Positives = 439/550 (79%), Gaps = 39/550 (7%)
Query: 172 VRFRCPAAGNPTPSISWLK----NG--------------REFRGEHRIGGIKLRHQQWSL 213
V F C + P I WLK NG + + E ++LR
Sbjct: 271 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLR------ 324
Query: 214 VMESVVPSDRGNYTCVVENKFGSIRQTYTLDVL-ERSPHRPILQAGLPANQTA-VLGSDV 271
+ +V D G Y C N G + + L V R+ +++A + A +L V
Sbjct: 325 -LANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGV 383
Query: 272 EFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVL-------KVSLESNASMSSNTP 324
F + A + L+ G G+P V + +VSLESNASMSSNTP
Sbjct: 384 GFFLFILVVAAVTLCRLRSPPKKGL-----GSPTVHKISRFPLKRQVSLESNASMSSNTP 438
Query: 325 LVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDK 384
LVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDK
Sbjct: 439 LVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDK 498
Query: 385 DRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVE 444
DRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVE
Sbjct: 499 DRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVE 558
Query: 445 YAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHR 504
YAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHR
Sbjct: 559 YAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHR 618
Query: 505 DLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSD 564
DLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSD
Sbjct: 619 DLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSD 678
Query: 565 VWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPS 624
VWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPS
Sbjct: 679 VWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPS 738
Query: 625 QRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPP 684
QRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPP
Sbjct: 739 QRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPP 798
Query: 685 APPSSGGSRT 694
APPSSGGSRT
Sbjct: 799 APPSSGGSRT 808
Score = 643 bits (1658), Expect = 0.0
Identities = 313/335 (93%), Positives = 317/335 (94%)
Query: 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS 60
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS
Sbjct: 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS 60
Query: 61 CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH 120
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH
Sbjct: 61 CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH 120
Query: 121 FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
Sbjct: 121 FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
Query: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
Sbjct: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
Query: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
Sbjct: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
Query: 301 DGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGE 335
DGTPYVTVLK + + L ++ GE
Sbjct: 301 DGTPYVTVLKSWISESVEADVRLRLANVSERDGGE 335
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 784 bits (2025), Expect = 0.0
Identities = 436/751 (58%), Positives = 502/751 (66%), Gaps = 82/751 (10%)
Query: 8 LALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGG 67
LAL + V G SL + V P E Q+++L G V L C G
Sbjct: 5 LALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQ-QEQELTVALGQPVRLCCGRAERG 63
Query: 68 PMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTD 127
W K+G+ L P+ RV RL++ + ED+G Y C R + VL + ++ D
Sbjct: 64 GH----WYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGD 119
Query: 128 A-PSSGDDEDGE---DEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPT 183
+ SS DDED + D + APYWT P+RM+KKL AVPA NTV+FRCPAAGNPT
Sbjct: 120 SLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPT 179
Query: 184 PSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTL 243
P+I WLK+G+ F GE+RIGGI+LRHQ WSLVMESVVPSDRG YTC+VEN GSIR Y L
Sbjct: 180 PTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLL 239
Query: 244 DVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHI------------------ 285
DVLERSPHRPILQAGLPAN TAV+GSDVE CKVYSDAQPHI
Sbjct: 240 DVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGF 299
Query: 286 ---QWLKHVEVNGSKV-------------------------------------GPDGTPY 305
Q LK ++N S+V G P+
Sbjct: 300 PYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPGTGRIPH 359
Query: 306 VT-------------VLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPK 352
+T L+ SLES +S S++ LVR RLSS LA + L+LP DP
Sbjct: 360 LTCDSLTPAGRTKSPTLQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPL 419
Query: 353 WELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVS 412
WE R RL LGKPLGEGCFGQVV AEA G+D R + TVAVKMLKD+A+DKDL+DLVS
Sbjct: 420 WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVS 479
Query: 413 EMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKP 472
EME+MK+IG+HKNIINLLG CTQ GPLYV+VE AAKGNLREFLRARRPPG D S D +
Sbjct: 480 EMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRS 539
Query: 473 PEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHN 532
E L+F LVSCAYQVARGM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR VH+
Sbjct: 540 SEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHH 599
Query: 533 LDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELF 592
+DYYKKT+NGRLPVKWMAPEALFDRVYTHQSDVWSFG+LLWEIFTLGGSPYPGIPVEELF
Sbjct: 600 IDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELF 659
Query: 593 KLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLS 652
LL+EGHRMD+P +C +LY +MRECWHAAPSQRPTFKQLVE LD+VL S +EYLDL
Sbjct: 660 SLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVS-EEYLDLR 718
Query: 653 APFEQYSPGGQDTPSSSSSGDDSVFAHDLLP 683
F YSP G D SS+ S DSVF+HD LP
Sbjct: 719 LTFGPYSPSGGDA-SSTCSSSDSVFSHDPLP 748
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 648 bits (1671), Expect = 0.0
Identities = 344/543 (63%), Positives = 400/543 (73%), Gaps = 36/543 (6%)
Query: 172 VRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIK----LRHQQWS------LVMESVVPS 221
V F C + P I W+K+ + ++ G+ L+H + L + +V +
Sbjct: 274 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEA 333
Query: 222 DRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGS----DVEFHCKV 277
D G Y C V N G Q+ L VL P QA P + + S ++ +C
Sbjct: 334 DAGEYICKVSNYIGQANQSAWLTVL------PKQQA--PGREKEITASPDYLEIAIYCIG 385
Query: 278 YSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLK------------VSLESNASMSSNTPL 325
+ + + + PD + V K VS ES++SM+SNTPL
Sbjct: 386 VFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPL 445
Query: 326 VRIA-RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGID 383
VRI RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GID
Sbjct: 446 VRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGID 505
Query: 384 KDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLV 443
KD+ + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+V
Sbjct: 506 KDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 565
Query: 444 EYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIH 503
EYA+KGNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIH
Sbjct: 566 EYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIH 625
Query: 504 RDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 563
RDLAARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQS
Sbjct: 626 RDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 685
Query: 564 DVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAP 623
DVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA P
Sbjct: 686 DVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVP 745
Query: 624 SQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLP 683
SQRPTFKQLVEDLDR+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D +P
Sbjct: 746 SQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMP 805
Query: 684 PAP 686
P
Sbjct: 806 YEP 808
Score = 325 bits (833), Expect = 9e-89
Identities = 167/296 (56%), Positives = 204/296 (68%), Gaps = 9/296 (3%)
Query: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Query: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
Query: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
Query: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
PSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYS
Sbjct: 223 PSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYS 282
Query: 280 DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGE 335
DAQPHIQW+KHVE NGSK GPDG PY+ VLK S N+S + L + +GE
Sbjct: 283 DAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHS-GINSSNAEVLALFNVTEADAGE 337
>gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
Length = 704
Score = 642 bits (1657), Expect = 0.0
Identities = 343/538 (63%), Positives = 396/538 (73%), Gaps = 29/538 (5%)
Query: 172 VRFRCPAAGNPTPSISWLK----NGREFRGEH-------RIGGIKLRHQQWS-LVMESVV 219
V F C + P I W+K NG ++ + + G+ ++ L + +V
Sbjct: 159 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVT 218
Query: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEF-HCKVY 278
D G YTC+ N G + L VL + A + A+ V C V
Sbjct: 219 FEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVV 278
Query: 279 SDAQPHIQWLKHVEVNGSKVGPDGTPYVTVL--------KVSLESNASMSSNTPLVRIA- 329
+ L ++ K P V L +VS ES++SM+SNTPLVRI
Sbjct: 279 TVI------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITT 332
Query: 330 RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAA 388
RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+
Sbjct: 333 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 392
Query: 389 KPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAK 448
+ VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+K
Sbjct: 393 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 452
Query: 449 GNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAA 508
GNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLAA
Sbjct: 453 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 512
Query: 509 RNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 568
RNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF
Sbjct: 513 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 572
Query: 569 GVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPT 628
GVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRPT
Sbjct: 573 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPT 632
Query: 629 FKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 686
FKQLVEDLDR+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D +P P
Sbjct: 633 FKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 690
Score = 275 bits (702), Expect = 1e-73
Identities = 126/172 (73%), Positives = 148/172 (86%), Gaps = 1/172 (0%)
Query: 142 EDTGVDT-GAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHR 200
EDT ++ GAPYWT E+M+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHR
Sbjct: 29 EDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR 88
Query: 201 IGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLP 260
IGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLP
Sbjct: 89 IGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLP 148
Query: 261 ANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVS 312
AN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG PY+ VLK +
Sbjct: 149 ANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAA 200
>gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
Length = 706
Score = 642 bits (1655), Expect = 0.0
Identities = 341/539 (63%), Positives = 395/539 (73%), Gaps = 29/539 (5%)
Query: 172 VRFRCPAAGNPTPSISWLK----NGREFRGEH-------RIGGIKLRHQQWS-LVMESVV 219
V F C + P I W+K NG ++ + + G+ ++ L + +V
Sbjct: 159 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVT 218
Query: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEF-HCKVY 278
D G YTC+ N G + L VL + A + A+ V C V
Sbjct: 219 FEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVV 278
Query: 279 S---------DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIA 329
+ +P V ++ P + VS ES++SM+SNTPLVRI
Sbjct: 279 TVILCRMKNTTKKPDFSSQPAVHKLTKRI-----PLRRQVTVSAESSSSMNSNTPLVRIT 333
Query: 330 -RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRA 387
RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+
Sbjct: 334 TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP 393
Query: 388 AKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAA 447
+ VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+
Sbjct: 394 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 453
Query: 448 KGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA 507
KGNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLA
Sbjct: 454 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLA 513
Query: 508 ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 567
ARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS
Sbjct: 514 ARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 573
Query: 568 FGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRP 627
FGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRP
Sbjct: 574 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 633
Query: 628 TFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 686
TFKQLVEDLDR+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D +P P
Sbjct: 634 TFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 692
Score = 275 bits (702), Expect = 1e-73
Identities = 126/172 (73%), Positives = 148/172 (86%), Gaps = 1/172 (0%)
Query: 142 EDTGVDT-GAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHR 200
EDT ++ GAPYWT E+M+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHR
Sbjct: 29 EDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR 88
Query: 201 IGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLP 260
IGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLP
Sbjct: 89 IGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLP 148
Query: 261 ANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVS 312
AN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG PY+ VLK +
Sbjct: 149 ANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAA 200
>gi|221316639 fibroblast growth factor receptor 2 isoform 1
precursor [Homo sapiens]
Length = 821
Score = 642 bits (1655), Expect = 0.0
Identities = 341/539 (63%), Positives = 395/539 (73%), Gaps = 29/539 (5%)
Query: 172 VRFRCPAAGNPTPSISWLK----NGREFRGEH-------RIGGIKLRHQQWS-LVMESVV 219
V F C + P I W+K NG ++ + + G+ ++ L + +V
Sbjct: 274 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVT 333
Query: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEF-HCKVY 278
D G YTC+ N G + L VL + A + A+ V C V
Sbjct: 334 FEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVV 393
Query: 279 S---------DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIA 329
+ +P V ++ P + VS ES++SM+SNTPLVRI
Sbjct: 394 TVILCRMKNTTKKPDFSSQPAVHKLTKRI-----PLRRQVTVSAESSSSMNSNTPLVRIT 448
Query: 330 -RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRA 387
RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+
Sbjct: 449 TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP 508
Query: 388 AKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAA 447
+ VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+
Sbjct: 509 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 568
Query: 448 KGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA 507
KGNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLA
Sbjct: 569 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLA 628
Query: 508 ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 567
ARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS
Sbjct: 629 ARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 688
Query: 568 FGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRP 627
FGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRP
Sbjct: 689 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 748
Query: 628 TFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 686
TFKQLVEDLDR+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D +P P
Sbjct: 749 TFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 807
Score = 323 bits (827), Expect = 4e-88
Identities = 161/273 (58%), Positives = 195/273 (71%), Gaps = 8/273 (2%)
Query: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Query: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
Query: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
Query: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
PSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYS
Sbjct: 223 PSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYS 282
Query: 280 DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVS 312
DAQPHIQW+KHVE NGSK GPDG PY+ VLK +
Sbjct: 283 DAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAA 315
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 635 bits (1639), Expect = 0.0
Identities = 364/705 (51%), Positives = 447/705 (63%), Gaps = 71/705 (10%)
Query: 20 ASSESLGTEQRVVGRAAEVP---GPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTV-WV 75
+SSE T+ R P PE +++ + V+ CP G PT+ W+
Sbjct: 45 SSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP--SSGTPNPTLRWL 102
Query: 76 KDGTGLVPSERVLVGPQRLQVLNAS-------HEDSGAYSCRQRLTQRVLCH-FSVRVTD 127
K+G P R+ G +++ S D G Y+C + H + + V
Sbjct: 103 KNGKEFKPDHRI--GGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVV- 159
Query: 128 APSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSIS 187
E + G P K +A+ + V F C +P P I
Sbjct: 160 ----------ERSPHRPILQAGLPA--------NKTVAL--GSNVEFMCKVYSDPQPHIQ 199
Query: 188 WLK----NGREFRGEH-------RIGGIKLRHQQWSLV-MESVVPSDRGNYTCVVENKFG 235
WLK NG + ++ + G+ ++ ++ + +V D G YTC+ N G
Sbjct: 200 WLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 259
Query: 236 SIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCK-------------VYSDAQ 282
+ L VLE RP A T+ L ++ +C VY
Sbjct: 260 LSHHSAWLTVLEALEERP-------AVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKS 312
Query: 283 PHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANV 342
+ H ++ K+ P + VS +S+ASM+S LVR +RLSS P LA V
Sbjct: 313 GTKKSDFHSQMAVHKLAKS-IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGV 371
Query: 343 SELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDA 402
SE ELP DP+WEL R RL LGKPLGEGCFGQVV+AEAIG+DKD+ + VAVKMLK DA
Sbjct: 372 SEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA 431
Query: 403 TDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPG 462
T+KDLSDL+SEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+L+ARRPPG
Sbjct: 432 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPG 491
Query: 463 LDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIA 522
L+Y ++ PEEQL+ KDLVSCAYQVARGMEYLAS+KCIHRDLAARNVLVTEDNVMKIA
Sbjct: 492 LEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA 551
Query: 523 DFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSP 582
DFGLARD+H++DYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVLLWEIFTLGGSP
Sbjct: 552 DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 611
Query: 583 YPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTV 642
YPG+PVEELFKLLKEGHRMDKP+NCT++LYM+MR+CWHA PSQRPTFKQLVEDLDR++ +
Sbjct: 612 YPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVAL 671
Query: 643 TSTDEYLDLSAPFEQYSPGGQDTPSSS-SSGDDSVFAHDLLPPAP 686
TS EYLDLS P +QYSP DT SS+ SSG+DSVF+H+ LP P
Sbjct: 672 TSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEP 716
Score = 273 bits (699), Expect = 3e-73
Identities = 124/192 (64%), Positives = 155/192 (80%), Gaps = 8/192 (4%)
Query: 129 PSSGDDEDGEDEA-EDTGVDTG-------APYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
PSS DD+D +D + E+ D APYWT PE+M+KKL AVPAA TV+F+CP++G
Sbjct: 34 PSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSG 93
Query: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
P P++ WLKNG+EF+ +HRIGG K+R+ WS++M+SVVPSD+GNYTC+VEN++GSI T
Sbjct: 94 TPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHT 153
Query: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
Y LDV+ERSPHRPILQAGLPAN+T LGS+VEF CKVYSD QPHIQWLKH+EVNGSK+GP
Sbjct: 154 YQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP 213
Query: 301 DGTPYVTVLKVS 312
D PYV +LK +
Sbjct: 214 DNLPYVQILKTA 225
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 635 bits (1639), Expect = 0.0
Identities = 364/705 (51%), Positives = 447/705 (63%), Gaps = 71/705 (10%)
Query: 20 ASSESLGTEQRVVGRAAEVP---GPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTV-WV 75
+SSE T+ R P PE +++ + V+ CP G PT+ W+
Sbjct: 134 SSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP--SSGTPNPTLRWL 191
Query: 76 KDGTGLVPSERVLVGPQRLQVLNAS-------HEDSGAYSCRQRLTQRVLCH-FSVRVTD 127
K+G P R+ G +++ S D G Y+C + H + + V
Sbjct: 192 KNGKEFKPDHRI--GGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVV- 248
Query: 128 APSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSIS 187
E + G P K +A+ + V F C +P P I
Sbjct: 249 ----------ERSPHRPILQAGLPA--------NKTVAL--GSNVEFMCKVYSDPQPHIQ 288
Query: 188 WLK----NGREFRGEH-------RIGGIKLRHQQWSLV-MESVVPSDRGNYTCVVENKFG 235
WLK NG + ++ + G+ ++ ++ + +V D G YTC+ N G
Sbjct: 289 WLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 348
Query: 236 SIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCK-------------VYSDAQ 282
+ L VLE RP A T+ L ++ +C VY
Sbjct: 349 LSHHSAWLTVLEALEERP-------AVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKS 401
Query: 283 PHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANV 342
+ H ++ K+ P + VS +S+ASM+S LVR +RLSS P LA V
Sbjct: 402 GTKKSDFHSQMAVHKLAKS-IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGV 460
Query: 343 SELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDA 402
SE ELP DP+WEL R RL LGKPLGEGCFGQVV+AEAIG+DKD+ + VAVKMLK DA
Sbjct: 461 SEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA 520
Query: 403 TDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPG 462
T+KDLSDL+SEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+L+ARRPPG
Sbjct: 521 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPG 580
Query: 463 LDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIA 522
L+Y ++ PEEQL+ KDLVSCAYQVARGMEYLAS+KCIHRDLAARNVLVTEDNVMKIA
Sbjct: 581 LEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA 640
Query: 523 DFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSP 582
DFGLARD+H++DYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVLLWEIFTLGGSP
Sbjct: 641 DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 700
Query: 583 YPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTV 642
YPG+PVEELFKLLKEGHRMDKP+NCT++LYM+MR+CWHA PSQRPTFKQLVEDLDR++ +
Sbjct: 701 YPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVAL 760
Query: 643 TSTDEYLDLSAPFEQYSPGGQDTPSSS-SSGDDSVFAHDLLPPAP 686
TS EYLDLS P +QYSP DT SS+ SSG+DSVF+H+ LP P
Sbjct: 761 TSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEP 805
Score = 300 bits (769), Expect = 2e-81
Identities = 145/284 (51%), Positives = 195/284 (68%), Gaps = 12/284 (4%)
Query: 39 PGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLN 98
P P + E + GD ++L C + W++DG L S R + + ++V +
Sbjct: 33 PWGAPVEVESFLVHPGDLLQLRCRLRDD--VQSINWLRDGVQLAESNRTRITGEEVEVQD 90
Query: 99 ASHEDSGAYSC-RQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG-------- 149
+ DSG Y+C + +FSV V+DA S +D+D +D++ +T
Sbjct: 91 SVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMP 150
Query: 150 -APYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRH 208
APYWT PE+M+KKL AVPAA TV+F+CP++G P P++ WLKNG+EF+ +HRIGG K+R+
Sbjct: 151 VAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRY 210
Query: 209 QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLG 268
WS++M+SVVPSD+GNYTC+VEN++GSI TY LDV+ERSPHRPILQAGLPAN+T LG
Sbjct: 211 ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALG 270
Query: 269 SDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVS 312
S+VEF CKVYSD QPHIQWLKH+EVNGSK+GPD PYV +LK +
Sbjct: 271 SNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTA 314
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 634 bits (1636), Expect = 0.0
Identities = 333/547 (60%), Positives = 395/547 (72%), Gaps = 34/547 (6%)
Query: 166 VPAANTVRFRCPAAGNPTPSISWLK----NGREFRGEH-------RIGGIKLRHQQWSLV 214
V + V F C +P P I WLK NG + ++ + G+ ++ ++
Sbjct: 176 VALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVL 235
Query: 215 -MESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEF 273
+ +V D G YTC+ N G + L VLE RP A T+ L ++
Sbjct: 236 HLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP-------AVMTSPLYLEIII 288
Query: 274 HCK-------------VYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMS 320
+C VY + H ++ K+ P + VS +S+ASM+
Sbjct: 289 YCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS-IPLRRQVTVSADSSASMN 347
Query: 321 SNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAI 380
S LVR +RLSS P LA VSE ELP DP+WEL R RL LGKPLGEGCFGQVV+AEAI
Sbjct: 348 SGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAI 407
Query: 381 GIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLY 440
G+DKD+ + VAVKMLK DAT+KDLSDL+SEMEMMKMIGKHKNIINLLGACTQ GPLY
Sbjct: 408 GLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLY 467
Query: 441 VLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQK 500
V+VEYA+KGNLRE+L+ARRPPGL+Y ++ PEEQL+ KDLVSCAYQVARGMEYLAS+K
Sbjct: 468 VIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKK 527
Query: 501 CIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYT 560
CIHRDLAARNVLVTEDNVMKIADFGLARD+H++DYYKKTTNGRLPVKWMAPEALFDR+YT
Sbjct: 528 CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYT 587
Query: 561 HQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWH 620
HQSDVWSFGVLLWEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCT++LYM+MR+CWH
Sbjct: 588 HQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH 647
Query: 621 AAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSS-SSGDDSVFAH 679
A PSQRPTFKQLVEDLDR++ +TS EYLDLS P +QYSP DT SS+ SSG+DSVF+H
Sbjct: 648 AVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSH 707
Query: 680 DLLPPAP 686
+ LP P
Sbjct: 708 EPLPEEP 714
Score = 277 bits (709), Expect = 2e-74
Identities = 124/190 (65%), Positives = 156/190 (82%), Gaps = 6/190 (3%)
Query: 129 PSSGDDEDGED------EAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNP 182
PSS DD+D +D E ++T + APYWT PE+M+KKL AVPAA TV+F+CP++G P
Sbjct: 34 PSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTP 93
Query: 183 TPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYT 242
P++ WLKNG+EF+ +HRIGG K+R+ WS++M+SVVPSD+GNYTC+VEN++GSI TY
Sbjct: 94 NPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQ 153
Query: 243 LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDG 302
LDV+ERSPHRPILQAGLPAN+T LGS+VEF CKVYSD QPHIQWLKH+EVNGSK+GPD
Sbjct: 154 LDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDN 213
Query: 303 TPYVTVLKVS 312
PYV +LK +
Sbjct: 214 LPYVQILKTA 223
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 634 bits (1636), Expect = 0.0
Identities = 333/547 (60%), Positives = 395/547 (72%), Gaps = 34/547 (6%)
Query: 166 VPAANTVRFRCPAAGNPTPSISWLK----NGREFRGEH-------RIGGIKLRHQQWSLV 214
V + V F C +P P I WLK NG + ++ + G+ ++ ++
Sbjct: 265 VALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVL 324
Query: 215 -MESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEF 273
+ +V D G YTC+ N G + L VLE RP A T+ L ++
Sbjct: 325 HLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERP-------AVMTSPLYLEIII 377
Query: 274 HCK-------------VYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMS 320
+C VY + H ++ K+ P + VS +S+ASM+
Sbjct: 378 YCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKS-IPLRRQVTVSADSSASMN 436
Query: 321 SNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAI 380
S LVR +RLSS P LA VSE ELP DP+WEL R RL LGKPLGEGCFGQVV+AEAI
Sbjct: 437 SGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAI 496
Query: 381 GIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLY 440
G+DKD+ + VAVKMLK DAT+KDLSDL+SEMEMMKMIGKHKNIINLLGACTQ GPLY
Sbjct: 497 GLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLY 556
Query: 441 VLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQK 500
V+VEYA+KGNLRE+L+ARRPPGL+Y ++ PEEQL+ KDLVSCAYQVARGMEYLAS+K
Sbjct: 557 VIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKK 616
Query: 501 CIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYT 560
CIHRDLAARNVLVTEDNVMKIADFGLARD+H++DYYKKTTNGRLPVKWMAPEALFDR+YT
Sbjct: 617 CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYT 676
Query: 561 HQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWH 620
HQSDVWSFGVLLWEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCT++LYM+MR+CWH
Sbjct: 677 HQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWH 736
Query: 621 AAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSS-SSGDDSVFAH 679
A PSQRPTFKQLVEDLDR++ +TS EYLDLS P +QYSP DT SS+ SSG+DSVF+H
Sbjct: 737 AVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSH 796
Query: 680 DLLPPAP 686
+ LP P
Sbjct: 797 EPLPEEP 803
Score = 304 bits (779), Expect = 2e-82
Identities = 149/282 (52%), Positives = 198/282 (70%), Gaps = 10/282 (3%)
Query: 39 PGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLN 98
P P + E + GD ++L C + W++DG L S R + + ++V +
Sbjct: 33 PWGAPVEVESFLVHPGDLLQLRCRLRDD--VQSINWLRDGVQLAESNRTRITGEEVEVQD 90
Query: 99 ASHEDSGAYSC-RQRLTQRVLCHFSVRVTDA-PSSGDDEDGED------EAEDTGVDTGA 150
+ DSG Y+C + +FSV V+DA PSS DD+D +D E ++T + A
Sbjct: 91 SVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVA 150
Query: 151 PYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQ 210
PYWT PE+M+KKL AVPAA TV+F+CP++G P P++ WLKNG+EF+ +HRIGG K+R+
Sbjct: 151 PYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYAT 210
Query: 211 WSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSD 270
WS++M+SVVPSD+GNYTC+VEN++GSI TY LDV+ERSPHRPILQAGLPAN+T LGS+
Sbjct: 211 WSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSN 270
Query: 271 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVS 312
VEF CKVYSD QPHIQWLKH+EVNGSK+GPD PYV +LK +
Sbjct: 271 VEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTA 312
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 598 bits (1541), Expect = e-171
Identities = 317/503 (63%), Positives = 371/503 (73%), Gaps = 36/503 (7%)
Query: 172 VRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIK----LRHQQWS------LVMESVVPS 221
V F C + P I W+K+ + ++ G+ L+H + L + +V +
Sbjct: 185 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEA 244
Query: 222 DRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGS----DVEFHCKV 277
D G Y C V N G Q+ L VL P QA P + + S ++ +C
Sbjct: 245 DAGEYICKVSNYIGQANQSAWLTVL------PKQQA--PGREKEITASPDYLEIAIYCIG 296
Query: 278 YSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLK------------VSLESNASMSSNTPL 325
+ + + + PD + V K VS ES++SM+SNTPL
Sbjct: 297 VFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPL 356
Query: 326 VRIA-RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGID 383
VRI RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GID
Sbjct: 357 VRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGID 416
Query: 384 KDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLV 443
KD+ + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+V
Sbjct: 417 KDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 476
Query: 444 EYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIH 503
EYA+KGNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIH
Sbjct: 477 EYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIH 536
Query: 504 RDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 563
RDLAARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQS
Sbjct: 537 RDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 596
Query: 564 DVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAP 623
DVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA P
Sbjct: 597 DVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVP 656
Query: 624 SQRPTFKQLVEDLDRVLTVTSTD 646
SQRPTFKQLVEDLDR+LT+T+ +
Sbjct: 657 SQRPTFKQLVEDLDRILTLTTNE 679
Score = 289 bits (739), Expect = 7e-78
Identities = 141/213 (66%), Positives = 165/213 (77%), Gaps = 5/213 (2%)
Query: 127 DAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERMDKKLLAVPAANTVRFRCPAAGNP 182
DA SSGDDED D AED + APYWT E+M+K+L AVPAANTV+FRCPA GNP
Sbjct: 37 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 96
Query: 183 TPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYT 242
P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI TY
Sbjct: 97 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 156
Query: 243 LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDG 302
LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG
Sbjct: 157 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 216
Query: 303 TPYVTVLKVSLESNASMSSNTPLVRIARLSSGE 335
PY+ VLK S N+S + L + +GE
Sbjct: 217 LPYLKVLKHS-GINSSNAEVLALFNVTEADAGE 248
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 598 bits (1541), Expect = e-171
Identities = 317/503 (63%), Positives = 371/503 (73%), Gaps = 36/503 (7%)
Query: 172 VRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIK----LRHQQWS------LVMESVVPS 221
V F C + P I W+K+ + ++ G+ L+H + L + +V +
Sbjct: 274 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEA 333
Query: 222 DRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGS----DVEFHCKV 277
D G Y C V N G Q+ L VL P QA P + + S ++ +C
Sbjct: 334 DAGEYICKVSNYIGQANQSAWLTVL------PKQQA--PGREKEITASPDYLEIAIYCIG 385
Query: 278 YSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLK------------VSLESNASMSSNTPL 325
+ + + + PD + V K VS ES++SM+SNTPL
Sbjct: 386 VFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPL 445
Query: 326 VRIA-RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGID 383
VRI RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GID
Sbjct: 446 VRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGID 505
Query: 384 KDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLV 443
KD+ + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+V
Sbjct: 506 KDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIV 565
Query: 444 EYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIH 503
EYA+KGNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIH
Sbjct: 566 EYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIH 625
Query: 504 RDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 563
RDLAARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQS
Sbjct: 626 RDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 685
Query: 564 DVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAP 623
DVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA P
Sbjct: 686 DVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVP 745
Query: 624 SQRPTFKQLVEDLDRVLTVTSTD 646
SQRPTFKQLVEDLDR+LT+T+ +
Sbjct: 746 SQRPTFKQLVEDLDRILTLTTNE 768
Score = 325 bits (833), Expect = 9e-89
Identities = 167/296 (56%), Positives = 204/296 (68%), Gaps = 9/296 (3%)
Query: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Query: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
Query: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
Query: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
PSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYS
Sbjct: 223 PSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYS 282
Query: 280 DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGE 335
DAQPHIQW+KHVE NGSK GPDG PY+ VLK S N+S + L + +GE
Sbjct: 283 DAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHS-GINSSNAEVLALFNVTEADAGE 337
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 596 bits (1536), Expect = e-170
Identities = 317/513 (61%), Positives = 372/513 (72%), Gaps = 29/513 (5%)
Query: 172 VRFRCPAAGNPTPSISWLK----NGREFRGEH-------RIGGIKLRHQQWS-LVMESVV 219
V F C + P I W+K NG ++ + + G+ ++ L + +V
Sbjct: 185 VEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVT 244
Query: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEF-HCKVY 278
D G YTC+ N G + L VL + A + A+ V C V
Sbjct: 245 FEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVV 304
Query: 279 S---------DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIA 329
+ +P V ++ P + VS ES++SM+SNTPLVRI
Sbjct: 305 TVILCRMKNTTKKPDFSSQPAVHKLTKRI-----PLRRQVTVSAESSSSMNSNTPLVRIT 359
Query: 330 -RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRA 387
RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+
Sbjct: 360 TRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKP 419
Query: 388 AKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAA 447
+ VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+
Sbjct: 420 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 479
Query: 448 KGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA 507
KGNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLA
Sbjct: 480 KGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLA 539
Query: 508 ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 567
ARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS
Sbjct: 540 ARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 599
Query: 568 FGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRP 627
FGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRP
Sbjct: 600 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 659
Query: 628 TFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSP 660
TFKQLVEDLDR+LT+T+ +E +S + + P
Sbjct: 660 TFKQLVEDLDRILTLTTNEEEKKVSGAVDCHKP 692
Score = 286 bits (733), Expect = 3e-77
Identities = 135/190 (71%), Positives = 156/190 (82%), Gaps = 4/190 (2%)
Query: 127 DAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERMDKKLLAVPAANTVRFRCPAAGNP 182
DA SSGDDED D AED + APYWT E+M+K+L AVPAANTV+FRCPA GNP
Sbjct: 37 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 96
Query: 183 TPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYT 242
P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI TY
Sbjct: 97 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 156
Query: 243 LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDG 302
LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG
Sbjct: 157 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 216
Query: 303 TPYVTVLKVS 312
PY+ VLK +
Sbjct: 217 LPYLKVLKAA 226
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 549 bits (1414), Expect = e-156
Identities = 335/658 (50%), Positives = 396/658 (60%), Gaps = 60/658 (9%)
Query: 53 SGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNAS-------HEDSG 105
+G+ V+ CP G P W+KDG R+ G RL+ + S D G
Sbjct: 164 AGNTVKFRCPA-AGNPTPTIRWLKDGQAFHGENRI--GGIRLRHQHWSLVMESVVPSDRG 220
Query: 106 AYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLL 164
Y+C + + ++ + V + A T V
Sbjct: 221 TYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAV------------------ 262
Query: 165 AVPAANTVRFRCPAAGNPTPSISWLK----NGREFR--GEHRIGGIKLRHQQWS----LV 214
+ V C + P I WLK NG F G + +K S L
Sbjct: 263 ---VGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLY 319
Query: 215 MESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFH 274
+ +V D G YTC+ N G Q+ L VL P A P + +D+ +
Sbjct: 320 LRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEED--PTWTAAAPEARY----TDIILY 373
Query: 275 CKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVS---------LESNASMSSNTPL 325
S A + L + + G P TV K+S LES +S S++ L
Sbjct: 374 ASG-SLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSL 432
Query: 326 VRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKD 385
VR RLSS LA + L+LP DP WE R RL LGKPLGEGCFGQVV AEA G+D
Sbjct: 433 VRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPA 492
Query: 386 RAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEY 445
R + TVAVKMLKD+A+DKDL+DLVSEME+MK+IG+HKNIINLLG CTQ GPLYV+VE
Sbjct: 493 RPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVEC 552
Query: 446 AAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRD 505
AAKGNLREFLRARRPPG D S D + E L+F LVSCAYQVARGM+YL S+KCIHRD
Sbjct: 553 AAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRD 612
Query: 506 LAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 565
LAARNVLVTEDNVMKIADFGLAR VH++DYYKKT+NGRLPVKWMAPEALFDRVYTHQSDV
Sbjct: 613 LAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDV 672
Query: 566 WSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQ 625
WSFG+LLWEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C +LY +MRECWHAAPSQ
Sbjct: 673 WSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQ 732
Query: 626 RPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLP 683
RPTFKQLVE LD+VL S +EYLDL F YSP G D SS+ S DSVF+HD LP
Sbjct: 733 RPTFKQLVEALDKVLLAVS-EEYLDLRLTFGPYSPSGGDA-SSTCSSSDSVFSHDPLP 788
Score = 310 bits (794), Expect = 3e-84
Identities = 177/340 (52%), Positives = 214/340 (62%), Gaps = 10/340 (2%)
Query: 8 LALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGG 67
LAL + V G SL + V P E Q+++L G V L C G
Sbjct: 5 LALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQ-QEQELTVALGQPVRLCCGRAERG 63
Query: 68 PMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTD 127
W K+G+ L P+ RV RL++ + ED+G Y C R + VL + ++ D
Sbjct: 64 GH----WYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGD 119
Query: 128 A-PSSGDDEDGE---DEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPT 183
+ SS DDED + D + APYWT P+RM+KKL AVPA NTV+FRCPAAGNPT
Sbjct: 120 SLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPT 179
Query: 184 PSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTL 243
P+I WLK+G+ F GE+RIGGI+LRHQ WSLVMESVVPSDRG YTC+VEN GSIR Y L
Sbjct: 180 PTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLL 239
Query: 244 DVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT 303
DVLERSPHRPILQAGLPAN TAV+GSDVE CKVYSDAQPHIQWLKH+ +NGS G DG
Sbjct: 240 DVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGF 299
Query: 304 PYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVS 343
PYV VLK + + N+S L ++ +GE LA S
Sbjct: 300 PYVQVLKTA-DINSSEVEVLYLRNVSAEDAGEYTCLAGNS 338
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 549 bits (1414), Expect = e-156
Identities = 335/658 (50%), Positives = 396/658 (60%), Gaps = 60/658 (9%)
Query: 53 SGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNAS-------HEDSG 105
+G+ V+ CP G P W+KDG R+ G RL+ + S D G
Sbjct: 164 AGNTVKFRCPA-AGNPTPTIRWLKDGQAFHGENRI--GGIRLRHQHWSLVMESVVPSDRG 220
Query: 106 AYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLL 164
Y+C + + ++ + V + A T V
Sbjct: 221 TYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAV------------------ 262
Query: 165 AVPAANTVRFRCPAAGNPTPSISWLK----NGREFR--GEHRIGGIKLRHQQWS----LV 214
+ V C + P I WLK NG F G + +K S L
Sbjct: 263 ---VGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLY 319
Query: 215 MESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFH 274
+ +V D G YTC+ N G Q+ L VL P A P + +D+ +
Sbjct: 320 LRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEED--PTWTAAAPEARY----TDIILY 373
Query: 275 CKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVS---------LESNASMSSNTPL 325
S A + L + + G P TV K+S LES +S S++ L
Sbjct: 374 ASG-SLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSL 432
Query: 326 VRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKD 385
VR RLSS LA + L+LP DP WE R RL LGKPLGEGCFGQVV AEA G+D
Sbjct: 433 VRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPA 492
Query: 386 RAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEY 445
R + TVAVKMLKD+A+DKDL+DLVSEME+MK+IG+HKNIINLLG CTQ GPLYV+VE
Sbjct: 493 RPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVEC 552
Query: 446 AAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRD 505
AAKGNLREFLRARRPPG D S D + E L+F LVSCAYQVARGM+YL S+KCIHRD
Sbjct: 553 AAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRD 612
Query: 506 LAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDV 565
LAARNVLVTEDNVMKIADFGLAR VH++DYYKKT+NGRLPVKWMAPEALFDRVYTHQSDV
Sbjct: 613 LAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDV 672
Query: 566 WSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQ 625
WSFG+LLWEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C +LY +MRECWHAAPSQ
Sbjct: 673 WSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQ 732
Query: 626 RPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLP 683
RPTFKQLVE LD+VL S +EYLDL F YSP G D SS+ S DSVF+HD LP
Sbjct: 733 RPTFKQLVEALDKVLLAVS-EEYLDLRLTFGPYSPSGGDA-SSTCSSSDSVFSHDPLP 788
Score = 310 bits (794), Expect = 3e-84
Identities = 177/340 (52%), Positives = 214/340 (62%), Gaps = 10/340 (2%)
Query: 8 LALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGG 67
LAL + V G SL + V P E Q+++L G V L C G
Sbjct: 5 LALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQ-QEQELTVALGQPVRLCCGRAERG 63
Query: 68 PMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTD 127
W K+G+ L P+ RV RL++ + ED+G Y C R + VL + ++ D
Sbjct: 64 GH----WYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGD 119
Query: 128 A-PSSGDDEDGE---DEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPT 183
+ SS DDED + D + APYWT P+RM+KKL AVPA NTV+FRCPAAGNPT
Sbjct: 120 SLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPT 179
Query: 184 PSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTL 243
P+I WLK+G+ F GE+RIGGI+LRHQ WSLVMESVVPSDRG YTC+VEN GSIR Y L
Sbjct: 180 PTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLL 239
Query: 244 DVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT 303
DVLERSPHRPILQAGLPAN TAV+GSDVE CKVYSDAQPHIQWLKH+ +NGS G DG
Sbjct: 240 DVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGF 299
Query: 304 PYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANVS 343
PYV VLK + + N+S L ++ +GE LA S
Sbjct: 300 PYVQVLKTA-DINSSEVEVLYLRNVSAEDAGEYTCLAGNS 338
>gi|13186249 fibroblast growth factor receptor 1 isoform 9 precursor
[Homo sapiens]
Length = 785
Score = 544 bits (1402), Expect = e-155
Identities = 333/705 (47%), Positives = 411/705 (58%), Gaps = 108/705 (15%)
Query: 20 ASSESLGTEQRVVGRAAEVP---GPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTV-WV 75
+SSE T+ R P PE +++ + V+ CP G PT+ W+
Sbjct: 134 SSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCP--SSGTPNPTLRWL 191
Query: 76 KDGTGLVPSERVLVGPQRLQVLNAS-------HEDSGAYSCRQRLTQRVLCH-FSVRVTD 127
K+G P R+ G +++ S D G Y+C + H + + V
Sbjct: 192 KNGKEFKPDHRI--GGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVV- 248
Query: 128 APSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSIS 187
E + G P K +A+ + V F C +P P I
Sbjct: 249 ----------ERSPHRPILQAGLPA--------NKTVAL--GSNVEFMCKVYSDPQPHIQ 288
Query: 188 WLK----NGREFRGEH-------RIGGIKLRHQQWSLV-MESVVPSDRGNYTCVVENKFG 235
WLK NG + ++ + G+ ++ ++ + +V D G YTC+ N G
Sbjct: 289 WLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIG 348
Query: 236 SIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCK-------------VYSDAQ 282
+ L VLE RP A T+ L ++ +C VY
Sbjct: 349 LSHHSAWLTVLEALEERP-------AVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKS 401
Query: 283 PHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTLANV 342
+ H ++ K+ P + VS +S+ASM+S LVR +RLSS P LA V
Sbjct: 402 GTKKSDFHSQMAVHKLAKS-IPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGV 460
Query: 343 SELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDA 402
SE ELP DP+WEL R RL LGKPLGEGCFGQVV+AEAIG+DKD+ + VAVKMLK DA
Sbjct: 461 SEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA 520
Query: 403 TDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPG 462
T+KDLSDL+SEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+L+ARRPPG
Sbjct: 521 TEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPG 580
Query: 463 LDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIA 522
L+Y ++ PEEQL+ KDLVSCAYQVARGMEYLAS+KCIHRDLAARNVLVTEDNVMKIA
Sbjct: 581 LEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA 640
Query: 523 DFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSP 582
DFGLARD+H++DYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVLLWEIFTLGGSP
Sbjct: 641 DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 700
Query: 583 YPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTV 642
YPG+PVEEL FKQLVEDLDR++ +
Sbjct: 701 YPGVPVEEL-------------------------------------FKQLVEDLDRIVAL 723
Query: 643 TSTDEYLDLSAPFEQYSPGGQDTPSSS-SSGDDSVFAHDLLPPAP 686
TS EYLDLS P +QYSP DT SS+ SSG+DSVF+H+ LP P
Sbjct: 724 TSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEP 768
Score = 300 bits (769), Expect = 2e-81
Identities = 145/284 (51%), Positives = 195/284 (68%), Gaps = 12/284 (4%)
Query: 39 PGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLN 98
P P + E + GD ++L C + W++DG L S R + + ++V +
Sbjct: 33 PWGAPVEVESFLVHPGDLLQLRCRLRDD--VQSINWLRDGVQLAESNRTRITGEEVEVQD 90
Query: 99 ASHEDSGAYSC-RQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG-------- 149
+ DSG Y+C + +FSV V+DA S +D+D +D++ +T
Sbjct: 91 SVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMP 150
Query: 150 -APYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRH 208
APYWT PE+M+KKL AVPAA TV+F+CP++G P P++ WLKNG+EF+ +HRIGG K+R+
Sbjct: 151 VAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRY 210
Query: 209 QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLG 268
WS++M+SVVPSD+GNYTC+VEN++GSI TY LDV+ERSPHRPILQAGLPAN+T LG
Sbjct: 211 ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALG 270
Query: 269 SDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVS 312
S+VEF CKVYSD QPHIQWLKH+EVNGSK+GPD PYV +LK +
Sbjct: 271 SNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTA 314
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 328 bits (840), Expect = 1e-89
Identities = 174/344 (50%), Positives = 226/344 (65%), Gaps = 23/344 (6%)
Query: 341 NVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKD 400
+V ++ DPKWE R L LGK LGEG FG+VV A A + K RA TVAVKMLK+
Sbjct: 705 SVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-KGRAGY-TTVAVKMLKE 762
Query: 401 DATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRP 460
+A+ +L DL+SE ++K + H ++I L GAC+Q GPL ++VEYA G+LR FLR R
Sbjct: 763 NASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK 821
Query: 461 PGLDY--------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVL 512
G Y S P E LT DL+S A+Q+++GM+YLA K +HRDLAARN+L
Sbjct: 822 VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNIL 881
Query: 513 VTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLL 572
V E MKI+DFGL+RDV+ D Y K + GR+PVKWMA E+LFD +YT QSDVWSFGVLL
Sbjct: 882 VAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLL 941
Query: 573 WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQL 632
WEI TLGG+PYPGIP E LF LLK GHRM++P NC+ ++Y +M +CW P +RP F +
Sbjct: 942 WEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI 1001
Query: 633 VEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSV 676
+DL++++ +YLDL+A TPS S DD +
Sbjct: 1002 SKDLEKMM--VKRRDYLDLAA----------STPSDSLIYDDGL 1033
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 328 bits (840), Expect = 1e-89
Identities = 174/344 (50%), Positives = 226/344 (65%), Gaps = 23/344 (6%)
Query: 341 NVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKD 400
+V ++ DPKWE R L LGK LGEG FG+VV A A + K RA TVAVKMLK+
Sbjct: 705 SVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-KGRAGY-TTVAVKMLKE 762
Query: 401 DATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRP 460
+A+ +L DL+SE ++K + H ++I L GAC+Q GPL ++VEYA G+LR FLR R
Sbjct: 763 NASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK 821
Query: 461 PGLDY--------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVL 512
G Y S P E LT DL+S A+Q+++GM+YLA K +HRDLAARN+L
Sbjct: 822 VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNIL 881
Query: 513 VTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLL 572
V E MKI+DFGL+RDV+ D Y K + GR+PVKWMA E+LFD +YT QSDVWSFGVLL
Sbjct: 882 VAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLL 941
Query: 573 WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQL 632
WEI TLGG+PYPGIP E LF LLK GHRM++P NC+ ++Y +M +CW P +RP F +
Sbjct: 942 WEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI 1001
Query: 633 VEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSV 676
+DL++++ +YLDL+A TPS S DD +
Sbjct: 1002 SKDLEKMM--VKRRDYLDLAA----------STPSDSLIYDDGL 1033
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
sapiens]
Length = 1338
Score = 324 bits (830), Expect = 2e-88
Identities = 224/632 (35%), Positives = 313/632 (49%), Gaps = 118/632 (18%)
Query: 94 LQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYW 153
L ++N S +DSG Y+CR R E+ + E T D APY
Sbjct: 621 LTIMNVSLQDSGTYACRARNVYT-----------------GEEILQKKEITIRDQEAPYL 663
Query: 154 TRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSL 213
R + +A+ ++ T+ C A G P P I+W KN + + E GI L +L
Sbjct: 664 LR--NLSDHTVAISSSTTLD--CHANGVPEPQITWFKNNHKIQQEP---GIILGPGSSTL 716
Query: 214 VMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEF 273
+E V D G Y C N+ GS+ + L V S S++E
Sbjct: 717 FIERVTEEDEGVYHCKATNQKGSVESSAYLTVQGTSDK-----------------SNLEL 759
Query: 274 HCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKVSLESNASMSSNTPLVRIARLSS 333
+ + WL + L + +S T + I +
Sbjct: 760 ITLTCTCVAATLFWL-----------------LLTLFIRKMKRSSSEIKTDYLSII-MDP 801
Query: 334 GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTV 393
E P L A KWE +R RL LGK LG G FG+VV A A GI K + TV
Sbjct: 802 DEVPLDEQCERLPYDAS-KWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCR--TV 858
Query: 394 AVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QGGPLYVLVEYAAKGNLR 452
AVKMLK+ AT + L++E++++ IG H N++NLLGACT QGGPL V+VEY GNL
Sbjct: 859 AVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLS 918
Query: 453 EFLRARRP--------------------PGL------------------------DYSFD 468
+L+++R PGL D S
Sbjct: 919 NYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLS 978
Query: 469 TCKPPE-------EQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKI 521
+ E E +T +DL+S ++QVARGME+L+S+KCIHRDLAARN+L++E+NV+KI
Sbjct: 979 DVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKI 1038
Query: 522 ADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGS 581
DFGLARD++ Y + + RLP+KWMAPE++FD++Y+ +SDVWS+GVLLWEIF+LGGS
Sbjct: 1039 CDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGS 1098
Query: 582 PYPGIPVEELF-KLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVL 640
PYPG+ ++E F L+EG RM P T ++Y IM +CWH P +RP F +LVE L +L
Sbjct: 1099 PYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLL 1158
Query: 641 TVT---STDEYLDLSAPFEQYSPGGQDTPSSS 669
+Y+ ++A S TP+ S
Sbjct: 1159 QANVQQDGKDYIPINAILTGNSGFTYSTPAFS 1190
Score = 43.5 bits (101), Expect = 7e-04
Identities = 34/141 (24%), Positives = 57/141 (40%), Gaps = 10/141 (7%)
Query: 154 TRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSL 213
T R + L V + R P+P + WLK+G + + + +SL
Sbjct: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEK----SARYLTRGYSL 390
Query: 214 VMESVVPSDRGNYTCVV----ENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGS 269
+++ V D GNYT ++ N F ++ T ++V + + + + P LGS
Sbjct: 391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPLGS 448
Query: 270 DVEFHCKVYSDAQPHIQWLKH 290
C Y QP I+W H
Sbjct: 449 RQILTCTAYGIPQPTIKWFWH 469
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 314 bits (804), Expect = 2e-85
Identities = 213/570 (37%), Positives = 286/570 (50%), Gaps = 125/570 (21%)
Query: 222 DRGNYTCVVENKFGSIRQTYT--LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
D+G+Y C+ +++ R L VLER P + L NQT +G +E C
Sbjct: 636 DQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIGESIEVSCTASG 692
Query: 280 DAQPHIQWLKHVEV---NGSKVGPDGTPYVTVLKVSLESN-------------------- 316
+ P I W K E + V DG +T+ +V E
Sbjct: 693 NPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFF 752
Query: 317 ----ASMSSNTPLV---------------------RIARLSSGEGPT--LANVSEL-ELP 348
A +N ++ + R + GE T L+ V + ELP
Sbjct: 753 IIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELP 812
Query: 349 ADP----------KWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKML 398
D KWE R RL LGKPLG G FGQV+ A+A GIDK + TVAVKML
Sbjct: 813 LDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCR--TVAVKML 870
Query: 399 KDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ-GGPLYVLVEYAAKGNLREFLRA 457
K+ AT + L+SE++++ IG H N++NLLGACT+ GGPL V+VE+ GNL +LR+
Sbjct: 871 KEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRS 930
Query: 458 RRPP-------------GLDY---------------------------------SFDTCK 471
+R G DY + +
Sbjct: 931 KRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEE 990
Query: 472 PPEEQ----LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLA 527
PE+ LT + L+ ++QVA+GME+LAS+KCIHRDLAARN+L++E NV+KI DFGLA
Sbjct: 991 APEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLA 1050
Query: 528 RDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIP 587
RD++ Y + + RLP+KWMAPE +FDRVYT QSDVWSFGVLLWEIF+LG SPYPG+
Sbjct: 1051 RDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVK 1110
Query: 588 VEELF-KLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTD 646
++E F + LKEG RM P T ++Y M +CWH PSQRPTF +LVE L +L +
Sbjct: 1111 IDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQ 1170
Query: 647 E-----YLDLSAPFEQYSPGGQDTPSSSSS 671
+ L +S G P+S S
Sbjct: 1171 DGKDYIVLPISETLSMEEDSGLSLPTSPVS 1200
Score = 45.8 bits (107), Expect = 1e-04
Identities = 34/133 (25%), Positives = 53/133 (39%), Gaps = 7/133 (5%)
Query: 161 KKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVP 220
+ L+ VR G P P I W KNG H IK H L + V
Sbjct: 337 ESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHT---IKAGH---VLTIMEVSE 390
Query: 221 SDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSD 280
D GNYT ++ N +Q++ + ++ P + ++ + + G+ C VY+
Sbjct: 391 RDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAI 450
Query: 281 AQP-HIQWLKHVE 292
P HI W +E
Sbjct: 451 PPPHHIHWYWQLE 463
Score = 37.0 bits (84), Expect = 0.062
Identities = 20/69 (28%), Positives = 32/69 (46%), Gaps = 3/69 (4%)
Query: 44 GQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLV--GPQRLQVLNASH 101
G E G+++E+SC G P +W KD LV +++ G + L +
Sbjct: 671 GNLENQTTSIGESIEVSCTA-SGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRK 729
Query: 102 EDSGAYSCR 110
ED G Y+C+
Sbjct: 730 EDEGLYTCQ 738
>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 2 precursor [Homo sapiens]
Length = 972
Score = 287 bits (734), Expect = 3e-77
Identities = 158/378 (41%), Positives = 217/378 (57%), Gaps = 63/378 (16%)
Query: 336 GPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAV 395
G + +LP D KWE R RL+ GK LG G FG+VV A A G+ K AA +TVAV
Sbjct: 561 GNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAA--MTVAV 618
Query: 396 KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 455
KMLK A + L+SE++++ +G H NI+NLLGACT GGP V+ EY G+L FL
Sbjct: 619 KMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFL 678
Query: 456 RARRP--------------------------------------PGLDYSFDT-------- 469
R +R PG+ Y T
Sbjct: 679 RRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSV 738
Query: 470 --------------CKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE 515
+ E L +DL+S +YQVA+GM +LAS+ CIHRDLAARN+L+T
Sbjct: 739 RIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH 798
Query: 516 DNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEI 575
+ KI DFGLARD+ N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ LWE+
Sbjct: 799 GRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWEL 858
Query: 576 FTLGGSPYPGIPVE-ELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVE 634
F+LG SPYPG+PV+ + +K++KEG RM P + ++Y IM+ CW A P +RPTFKQ+V+
Sbjct: 859 FSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 918
Query: 635 DLDRVLTVTSTDEYLDLS 652
+++ ++ ++ Y +L+
Sbjct: 919 LIEKQISESTNHIYSNLA 936
Score = 30.8 bits (68), Expect = 4.4
Identities = 14/40 (35%), Positives = 23/40 (57%)
Query: 209 QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLER 248
+Q +L + S +D G + C N FGS T TL+V+++
Sbjct: 271 RQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDK 310
>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 1 precursor [Homo sapiens]
Length = 976
Score = 287 bits (734), Expect = 3e-77
Identities = 158/378 (41%), Positives = 217/378 (57%), Gaps = 63/378 (16%)
Query: 336 GPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAV 395
G + +LP D KWE R RL+ GK LG G FG+VV A A G+ K AA +TVAV
Sbjct: 565 GNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAA--MTVAV 622
Query: 396 KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 455
KMLK A + L+SE++++ +G H NI+NLLGACT GGP V+ EY G+L FL
Sbjct: 623 KMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFL 682
Query: 456 RARRP--------------------------------------PGLDYSFDT-------- 469
R +R PG+ Y T
Sbjct: 683 RRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSV 742
Query: 470 --------------CKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE 515
+ E L +DL+S +YQVA+GM +LAS+ CIHRDLAARN+L+T
Sbjct: 743 RIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH 802
Query: 516 DNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEI 575
+ KI DFGLARD+ N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ LWE+
Sbjct: 803 GRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWEL 862
Query: 576 FTLGGSPYPGIPVE-ELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVE 634
F+LG SPYPG+PV+ + +K++KEG RM P + ++Y IM+ CW A P +RPTFKQ+V+
Sbjct: 863 FSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 922
Query: 635 DLDRVLTVTSTDEYLDLS 652
+++ ++ ++ Y +L+
Sbjct: 923 LIEKQISESTNHIYSNLA 940
Score = 30.8 bits (68), Expect = 4.4
Identities = 14/40 (35%), Positives = 23/40 (57%)
Query: 209 QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLER 248
+Q +L + S +D G + C N FGS T TL+V+++
Sbjct: 271 RQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDK 310
>gi|13186241 fibroblast growth factor receptor 1 isoform 6 precursor
[Homo sapiens]
Length = 300
Score = 278 bits (712), Expect = 9e-75
Identities = 125/189 (66%), Positives = 156/189 (82%), Gaps = 6/189 (3%)
Query: 129 PSSGDDEDGED------EAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNP 182
PSS DD+D +D E ++T + APYWT PE+M+KKL AVPAA TV+F+CP++G P
Sbjct: 34 PSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTP 93
Query: 183 TPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYT 242
P++ WLKNG+EF+ +HRIGG K+R+ WS++M+SVVPSD+GNYTC+VEN++GSI TY
Sbjct: 94 NPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQ 153
Query: 243 LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDG 302
LDV+ERSPHRPILQAGLPAN+T LGS+VEF CKVYSD QPHIQWLKH+EVNGSK+GPD
Sbjct: 154 LDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDN 213
Query: 303 TPYVTVLKV 311
PYV +LKV
Sbjct: 214 LPYVQILKV 222
>gi|13186238 fibroblast growth factor receptor 1 isoform 5 precursor
[Homo sapiens]
Length = 302
Score = 275 bits (702), Expect = 1e-73
Identities = 125/191 (65%), Positives = 155/191 (81%), Gaps = 8/191 (4%)
Query: 129 PSSGDDEDGEDEA-EDTGVDTG-------APYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
PSS DD+D +D + E+ D APYWT PE+M+KKL AVPAA TV+F+CP++G
Sbjct: 34 PSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSG 93
Query: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
P P++ WLKNG+EF+ +HRIGG K+R+ WS++M+SVVPSD+GNYTC+VEN++GSI T
Sbjct: 94 TPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHT 153
Query: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
Y LDV+ERSPHRPILQAGLPAN+T LGS+VEF CKVYSD QPHIQWLKH+EVNGSK+GP
Sbjct: 154 YQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP 213
Query: 301 DGTPYVTVLKV 311
D PYV +LKV
Sbjct: 214 DNLPYVQILKV 224
>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
Length = 1124
Score = 249 bits (637), Expect = 5e-66
Identities = 137/306 (44%), Positives = 195/306 (63%), Gaps = 11/306 (3%)
Query: 366 LGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 425
+GEG FGQV+ A I KD + A+K +K+ A+ D D E+E++ +G H N
Sbjct: 830 IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
Query: 426 IINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSC 485
IINLLGAC G LY+ +EYA GNL +FLR R D +F L+ + L+
Sbjct: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
Query: 486 AYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLP 545
A VARGM+YL+ ++ IHRDLAARN+LV E+ V KIADFGL+R + Y K T GRLP
Sbjct: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001
Query: 546 VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 605
V+WMA E+L VYT SDVWS+GVLLWEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
Query: 606 NCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDT 665
NC ++Y +MR+CW P +RP+F Q++ L+R+L T Y++ + +E+++ G D
Sbjct: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKT--YVNTTL-YEKFTYAGIDC 1118
Query: 666 PSSSSS 671
+ ++
Sbjct: 1119 SAEEAA 1124
>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
domains 1 [Homo sapiens]
Length = 1138
Score = 249 bits (637), Expect = 5e-66
Identities = 150/349 (42%), Positives = 206/349 (59%), Gaps = 24/349 (6%)
Query: 328 IARLSSGEGPTLANVSELELPADP------KWELSRARLTLGKPLGEGCFGQVVMAEAIG 381
I + SSG TL +L +P +WE +T +GEG FGQV+ A
Sbjct: 808 ILQFSSG---TLTLTRRPKLQPEPLSYPVLEWE----DITFEDLIGEGNFGQVIRAM--- 857
Query: 382 IDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYV 441
I KD + A+KMLK+ A++ D D E+E++ +G H NIINLLGAC G LY+
Sbjct: 858 IKKD--GLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYI 915
Query: 442 LVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKC 501
+EYA GNL +FLR R D +F L+ + L+ A A GM+YL+ ++
Sbjct: 916 AIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQF 975
Query: 502 IHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTH 561
IHRDLAARNVLV E+ KIADFGL+R + Y K T GRLPV+WMA E+L VYT
Sbjct: 976 IHRDLAARNVLVGENLASKIADFGLSRGE---EVYVKKTMGRLPVRWMAIESLNYSVYTT 1032
Query: 562 QSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHA 621
+SDVWSFGVLLWEI +LGG+PY G+ EL++ L +G+RM++P NC ++Y +MR+CW
Sbjct: 1033 KSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRD 1092
Query: 622 APSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSS 670
P +RP F Q+ L R+L Y+++S FE ++ G D + +
Sbjct: 1093 RPYERPPFAQIALQLGRMLEARKA--YVNMSL-FENFTYAGIDATAEEA 1138
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,164,617
Number of Sequences: 37866
Number of extensions: 1641674
Number of successful extensions: 10317
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 704
Number of HSP's successfully gapped in prelim test: 345
Number of HSP's that attempted gapping in prelim test: 5165
Number of HSP's gapped (non-prelim): 2958
length of query: 694
length of database: 18,247,518
effective HSP length: 109
effective length of query: 585
effective length of database: 14,120,124
effective search space: 8260272540
effective search space used: 8260272540
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.