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Search of human proteins with 4505127
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505127 melanocortin 2 receptor [Homo sapiens]
(297 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505127 melanocortin 2 receptor [Homo sapiens] 597 e-171
gi|5174535 melanocortin 5 receptor [Homo sapiens] 281 6e-76
gi|170671732 melanocortin 3 receptor [Homo sapiens] 279 2e-75
gi|119508433 melanocortin 4 receptor [Homo sapiens] 278 3e-75
gi|193083134 melanocortin 1 receptor [Homo sapiens] 223 1e-58
gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens] 106 3e-23
gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens] 106 3e-23
gi|4885295 G protein-coupled receptor 12 [Homo sapiens] 105 6e-23
gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens] 104 1e-22
gi|5921992 adenosine A2a receptor [Homo sapiens] 101 9e-22
gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens] 100 2e-21
gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens] 100 2e-21
gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens] 100 2e-21
gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens] 100 2e-21
gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens] 100 2e-21
gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens] 100 2e-21
gi|38788193 sphingosine-1-phosphate receptor 3 [Homo sapiens] 99 6e-21
gi|4885325 G protein-coupled receptor 3 [Homo sapiens] 99 6e-21
gi|134244587 endothelial differentiation, sphingolipid G-protein... 92 5e-19
gi|5174593 melatonin receptor 1A [Homo sapiens] 89 5e-18
gi|4501951 adenosine A2b receptor [Homo sapiens] 89 5e-18
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 88 8e-18
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 88 8e-18
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 88 8e-18
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 88 8e-18
gi|170932505 neuromedin U receptor 2 [Homo sapiens] 87 2e-17
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 86 3e-17
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 84 1e-16
gi|4885341 G protein-coupled receptor 6 [Homo sapiens] 82 6e-16
gi|7305013 lysophosphatidic acid receptor 2 [Homo sapiens] 81 1e-15
>gi|4505127 melanocortin 2 receptor [Homo sapiens]
Length = 297
Score = 597 bits (1540), Expect = e-171
Identities = 297/297 (100%), Positives = 297/297 (100%)
Query: 1 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMY 60
MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMY
Sbjct: 1 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMY 60
Query: 61 FFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFS 120
FFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFS
Sbjct: 61 FFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFS 120
Query: 121 LSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTS 180
LSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTS
Sbjct: 121 LSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTS 180
Query: 181 LFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVL 240
LFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVL
Sbjct: 181 LFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVL 240
Query: 241 LMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW 297
LMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW
Sbjct: 241 LMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW 297
>gi|5174535 melanocortin 5 receptor [Homo sapiens]
Length = 325
Score = 281 bits (718), Expect = 6e-76
Identities = 134/288 (46%), Positives = 194/288 (67%), Gaps = 7/288 (2%)
Query: 13 NTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDML 72
N +S C + + E+F T+ ++ +LEN++V+ A+ KNKNL +PMYFF+CSLA++DML
Sbjct: 25 NVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADML 84
Query: 73 GSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITI 132
S+ E I I L N +L +F D++ DS+ +S++ S+ SL IA DRY+TI
Sbjct: 85 VSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTI 144
Query: 133 FHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTSLFPLMLVFILCL 192
F+ALRYH I+T RR+ ++ IW FCTG GI +++S ++ S+F ML ++ L
Sbjct: 145 FYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSL 204
Query: 193 YVHMFLLARSHTRKISTLP-------RANMKGAITLTILLGVFIFCWAPFVLHVLLMTFC 245
Y+HMFLLAR+H ++I+ LP R +M+GA+T+T+LLGVF CWAPF LH+ LM C
Sbjct: 205 YIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSC 264
Query: 246 PSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFC 293
P N YC+ +MS F + +LIMCN+V+DP IYAFRS E+R FK++I C
Sbjct: 265 PQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICC 312
>gi|170671732 melanocortin 3 receptor [Homo sapiens]
Length = 323
Score = 279 bits (714), Expect = 2e-75
Identities = 133/280 (47%), Positives = 193/280 (68%), Gaps = 9/280 (3%)
Query: 21 CPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILE 80
C +V + E+F ++ IV +LEN++V+LAV +N NL +PMYFF+CSLA++DML S+ LE
Sbjct: 35 CEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALE 94
Query: 81 NILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHS 140
I+I + + YL F D+I DS+ +SL+ SI +L IA DRY+TIF+ALRYHS
Sbjct: 95 TIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHS 154
Query: 141 IVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTSLFPLMLVFILCLYVHMFLLA 200
I+T+R+ + ++ IW C G+ +++S ++ ++F M++ + LYVHMFL A
Sbjct: 155 IMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFA 214
Query: 201 RSHTRKISTLPRAN---------MKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYC 251
R H ++I+ LP A+ MKGA+T+TILLGVFIFCWAPF LH++L+ CP+NPYC
Sbjct: 215 RLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYC 274
Query: 252 ACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMI 291
CY + F +LIMCN+VIDP IYAFRS ELR+ F++++
Sbjct: 275 ICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREIL 314
>gi|119508433 melanocortin 4 receptor [Homo sapiens]
Length = 332
Score = 278 bits (712), Expect = 3e-75
Identities = 139/295 (47%), Positives = 197/295 (66%), Gaps = 8/295 (2%)
Query: 6 NSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICS 65
N+ E++ + ++ + E+F T+ ++ +LEN++V++A+ KNKNL +PMYFFICS
Sbjct: 26 NASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICS 85
Query: 66 LAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIA 125
LA++DML S+ E I+I L N + SF D++IDS+ SLL SI SL IA
Sbjct: 86 LAVADMLVSVSNGSETIVITLLNSTDTDAQ-SFTVNIDNVIDSVICSSLLASICSLLSIA 144
Query: 126 ADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTSLFPLM 185
DRY TIF+AL+YH+I+T++R ++++ IW CT +GI +I+S +I ++F M
Sbjct: 145 VDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTM 204
Query: 186 LVFILCLYVHMFLLARSHTRKISTLPR-------ANMKGAITLTILLGVFIFCWAPFVLH 238
L + LYVHMFL+AR H ++I+ LP ANMKGAITLTIL+GVF+ CWAPF LH
Sbjct: 205 LALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLH 264
Query: 239 VLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFC 293
++ CP NPYC C+MS F + +LIMCN++IDP IYA RS ELR FK++I C
Sbjct: 265 LIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICC 319
>gi|193083134 melanocortin 1 receptor [Homo sapiens]
Length = 317
Score = 223 bits (569), Expect = 1e-58
Identities = 115/282 (40%), Positives = 163/282 (57%), Gaps = 8/282 (2%)
Query: 21 CPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILE 80
C V + + +F ++ +V ++EN +V+ + KN+NL +PMY FIC LA+SD+L S +LE
Sbjct: 35 CLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLE 94
Query: 81 NILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHS 140
+I+L G L R + D++ID + S+L S+ L IA DRYI+IF+ALRYHS
Sbjct: 95 TAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHS 154
Query: 141 IVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTSLFPLMLVFILCLYVHMFLLA 200
IVT+ R + IW + + HV ++ F MLV + LYVHM A
Sbjct: 155 IVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARA 214
Query: 201 RSHTRKISTLPRA--------NMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCA 252
H + I+ L + +KGA+TLTILLG+F CW PF LH+ L+ CP +P C
Sbjct: 215 CQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCG 274
Query: 253 CYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCS 294
C F + LI+CNA+IDP IYAF S ELR K+++ CS
Sbjct: 275 CIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCS 316
>gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens]
Length = 364
Score = 106 bits (264), Expect = 3e-23
Identities = 83/285 (29%), Positives = 140/285 (49%), Gaps = 34/285 (11%)
Query: 33 TISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYL 92
T+ I +L NL+V++A++ N+ P+Y+ + +LA +D L ++ N G
Sbjct: 58 TVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGL-----AYFYLMFNTGPN 112
Query: 93 KPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLT 152
R + T + L SL S+ +L IA +R+IT+F ++ H+ ++ RR VVV+
Sbjct: 113 TRRLTVSTWL--LRQGLIDTSLTASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIV 169
Query: 153 VIWTFCTGTGITMVI----------FSHHVP----TVITFTSLFPLM-LVFILCLYVHMF 197
VIWT G + S+ P + + F ++F L+ V ++ LY H+F
Sbjct: 170 VIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIF 229
Query: 198 LLARSHTRKI---STLPRAN----MKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPY 250
R T ++ S+ PR N M T+ I+LG FI CW P ++ +LL CP
Sbjct: 230 GYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDV 289
Query: 251 CACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSR 295
A Y F +L N+ ++P IY++R E+ F++++ C R
Sbjct: 290 LA-YEKFFL---LLAEFNSAMNPIIYSYRDKEMSATFRQILCCQR 330
>gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens]
Length = 364
Score = 106 bits (264), Expect = 3e-23
Identities = 83/285 (29%), Positives = 140/285 (49%), Gaps = 34/285 (11%)
Query: 33 TISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYL 92
T+ I +L NL+V++A++ N+ P+Y+ + +LA +D L ++ N G
Sbjct: 58 TVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGL-----AYFYLMFNTGPN 112
Query: 93 KPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLT 152
R + T + L SL S+ +L IA +R+IT+F ++ H+ ++ RR VVV+
Sbjct: 113 TRRLTVSTWL--LRQGLIDTSLTASVANLLAIAIERHITVFR-MQLHTRMSNRRVVVVIV 169
Query: 153 VIWTFCTGTGITMVI----------FSHHVP----TVITFTSLFPLM-LVFILCLYVHMF 197
VIWT G + S+ P + + F ++F L+ V ++ LY H+F
Sbjct: 170 VIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIF 229
Query: 198 LLARSHTRKI---STLPRAN----MKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPY 250
R T ++ S+ PR N M T+ I+LG FI CW P ++ +LL CP
Sbjct: 230 GYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDV 289
Query: 251 CACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSR 295
A Y F +L N+ ++P IY++R E+ F++++ C R
Sbjct: 290 LA-YEKFFL---LLAEFNSAMNPIIYSYRDKEMSATFRQILCCQR 330
>gi|4885295 G protein-coupled receptor 12 [Homo sapiens]
Length = 334
Score = 105 bits (261), Expect = 6e-23
Identities = 78/269 (28%), Positives = 126/269 (46%), Gaps = 41/269 (15%)
Query: 41 ENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFET 100
EN IV+L +F N +L+APM+ I SLA++D+L + I + L ++
Sbjct: 61 ENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYL-----------LQS 109
Query: 101 TADDIID-SLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCT 159
A ++ L V S S+ SL I DRY+++++AL YHS T+ T V+L ++W
Sbjct: 110 EATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSI 169
Query: 160 GTGITMVIFSHHVPTVITFTSLFPL--------------MLVFILCLYVHMFLLARSHTR 205
G+ V+ + + T + + PL M +L LY+ + + H
Sbjct: 170 CLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAH 229
Query: 206 KISTLPR--------ANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSL 257
+I+ KG TL I+LG F CW PF L+ L+ + + P Y +L
Sbjct: 230 QIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADY--TYPSIYTYATL 287
Query: 258 FQVNGMLIMCNAVIDPFIYAFRSPELRDA 286
N++I+P IYAFR+ E++ A
Sbjct: 288 LPAT-----YNSIINPVIYAFRNQEIQKA 311
>gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens]
Length = 382
Score = 104 bits (259), Expect = 1e-22
Identities = 86/298 (28%), Positives = 144/298 (48%), Gaps = 38/298 (12%)
Query: 24 VVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENIL 83
+ L +F I +LEN+ VLL ++K K PMY+FI +LA+SD+L + N+L
Sbjct: 45 IKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGV-AYTANLL 103
Query: 84 IILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVT 143
+ L P F S+FV +L S+FSL IA +RYIT+ ++ H+
Sbjct: 104 LSGATTYKLTPAQWFLREG-----SMFV-ALSASVFSLLAIAIERYITML-KMKLHNGSN 156
Query: 144 MRRTVVVLTVIWTFCTGTG---------------ITMVIFSHHVPTVITFTSLFPLMLVF 188
R ++++ W G + V+ +H ++ T++F L+L+
Sbjct: 157 NFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLS 216
Query: 189 ILCLYVHMFLLARSHTRK------ISTLPRANMKGAI---TLTILLGVFIFCWAPFVLHV 239
I+ LY ++ L R+ +R+ IS R++ K T+ I+L VFI CWAP + +
Sbjct: 217 IVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILL 276
Query: 240 LLMTFCPSNPYCACYMSLFQVNGMLIMC--NAVIDPFIYAFRSPELRDAFKKMIFCSR 295
LL C C + LF+ L++ N+ +P IY + E+R AF +++ C +
Sbjct: 277 LLDVGCKVK---TCDI-LFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCK 330
>gi|5921992 adenosine A2a receptor [Homo sapiens]
Length = 412
Score = 101 bits (251), Expect = 9e-22
Identities = 82/299 (27%), Positives = 134/299 (44%), Gaps = 52/299 (17%)
Query: 34 ISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLK 93
I+++ +L N++V AV+ N NLQ +F+ SLA +D+ + I I I
Sbjct: 16 IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITI--------- 66
Query: 94 PRGSFETTADDIIDSLFVLSLL-GSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLT 152
G + + FVL L SIFSL IA DRYI I LRY+ +VT R ++
Sbjct: 67 STGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIA 126
Query: 153 VIWTFCTGTGITMV--------------------------IFSHHVP-TVITFTSLFPLM 185
+ W G+T + +F VP + + + F +
Sbjct: 127 ICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACV 186
Query: 186 LV---FILCLYVHMFLLARSHTRKISTLP----------RANMKGAITLTILLGVFIFCW 232
LV +L +Y+ +FL AR +++ + P + + A +L I++G+F CW
Sbjct: 187 LVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCW 246
Query: 233 APFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMI 291
P + FCP + ++ + +L N+V++PFIYA+R E R F+K+I
Sbjct: 247 LPLHIINCFTFFCPDCSHAPLWLMYLAI--VLSHTNSVVNPFIYAYRIREFRQTFRKII 303
>gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 100 bits (248), Expect = 2e-21
Identities = 84/305 (27%), Positives = 133/305 (43%), Gaps = 65/305 (21%)
Query: 33 TISIVGVLENLIVLLAVFKNKNLQA-PMYFFICSLAISDMLGSLYKILENILIIL----- 86
T+ VLENL+VL + +++L+ P Y FI SLA++D+LGS+ + I +
Sbjct: 125 TLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKD 184
Query: 87 -RNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMR 145
RN+ K G S S+ SL + A DRYI+I L Y IVT
Sbjct: 185 SRNVFLFKLGG-------------VTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRP 231
Query: 146 RTVVVLTVIWTFCTGTGITMV--------------IFSHHVPTVITF-TSLFPLMLVFIL 190
+ VV ++WT + + IF H T + F + ++L+FI
Sbjct: 232 KAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFI- 290
Query: 191 CLYVHMFLLARSHTRKISTLPRANMKGAI-------------------------TLTILL 225
+Y +M++L ++H+ + + R K I TL ++L
Sbjct: 291 -VYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLIL 349
Query: 226 GVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRD 285
V I CW P + ++ F N ++F ML + N+ ++P IYA RS +LR
Sbjct: 350 VVLIICWGPLLAIMVYDVFGKMN---KLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRH 406
Query: 286 AFKKM 290
AF+ M
Sbjct: 407 AFRSM 411
>gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 100 bits (248), Expect = 2e-21
Identities = 84/305 (27%), Positives = 133/305 (43%), Gaps = 65/305 (21%)
Query: 33 TISIVGVLENLIVLLAVFKNKNLQA-PMYFFICSLAISDMLGSLYKILENILIIL----- 86
T+ VLENL+VL + +++L+ P Y FI SLA++D+LGS+ + I +
Sbjct: 125 TLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKD 184
Query: 87 -RNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMR 145
RN+ K G S S+ SL + A DRYI+I L Y IVT
Sbjct: 185 SRNVFLFKLGG-------------VTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRP 231
Query: 146 RTVVVLTVIWTFCTGTGITMV--------------IFSHHVPTVITF-TSLFPLMLVFIL 190
+ VV ++WT + + IF H T + F + ++L+FI
Sbjct: 232 KAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFI- 290
Query: 191 CLYVHMFLLARSHTRKISTLPRANMKGAI-------------------------TLTILL 225
+Y +M++L ++H+ + + R K I TL ++L
Sbjct: 291 -VYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLIL 349
Query: 226 GVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRD 285
V I CW P + ++ F N ++F ML + N+ ++P IYA RS +LR
Sbjct: 350 VVLIICWGPLLAIMVYDVFGKMN---KLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRH 406
Query: 286 AFKKM 290
AF+ M
Sbjct: 407 AFRSM 411
>gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 100 bits (248), Expect = 2e-21
Identities = 84/305 (27%), Positives = 133/305 (43%), Gaps = 65/305 (21%)
Query: 33 TISIVGVLENLIVLLAVFKNKNLQA-PMYFFICSLAISDMLGSLYKILENILIIL----- 86
T+ VLENL+VL + +++L+ P Y FI SLA++D+LGS+ + I +
Sbjct: 125 TLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKD 184
Query: 87 -RNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMR 145
RN+ K G S S+ SL + A DRYI+I L Y IVT
Sbjct: 185 SRNVFLFKLGG-------------VTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRP 231
Query: 146 RTVVVLTVIWTFCTGTGITMV--------------IFSHHVPTVITF-TSLFPLMLVFIL 190
+ VV ++WT + + IF H T + F + ++L+FI
Sbjct: 232 KAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFI- 290
Query: 191 CLYVHMFLLARSHTRKISTLPRANMKGAI-------------------------TLTILL 225
+Y +M++L ++H+ + + R K I TL ++L
Sbjct: 291 -VYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLIL 349
Query: 226 GVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRD 285
V I CW P + ++ F N ++F ML + N+ ++P IYA RS +LR
Sbjct: 350 VVLIICWGPLLAIMVYDVFGKMN---KLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRH 406
Query: 286 AFKKM 290
AF+ M
Sbjct: 407 AFRSM 411
>gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 100 bits (248), Expect = 2e-21
Identities = 84/305 (27%), Positives = 133/305 (43%), Gaps = 65/305 (21%)
Query: 33 TISIVGVLENLIVLLAVFKNKNLQA-PMYFFICSLAISDMLGSLYKILENILIIL----- 86
T+ VLENL+VL + +++L+ P Y FI SLA++D+LGS+ + I +
Sbjct: 125 TLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKD 184
Query: 87 -RNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMR 145
RN+ K G S S+ SL + A DRYI+I L Y IVT
Sbjct: 185 SRNVFLFKLGG-------------VTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRP 231
Query: 146 RTVVVLTVIWTFCTGTGITMV--------------IFSHHVPTVITF-TSLFPLMLVFIL 190
+ VV ++WT + + IF H T + F + ++L+FI
Sbjct: 232 KAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFI- 290
Query: 191 CLYVHMFLLARSHTRKISTLPRANMKGAI-------------------------TLTILL 225
+Y +M++L ++H+ + + R K I TL ++L
Sbjct: 291 -VYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLIL 349
Query: 226 GVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRD 285
V I CW P + ++ F N ++F ML + N+ ++P IYA RS +LR
Sbjct: 350 VVLIICWGPLLAIMVYDVFGKMN---KLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRH 406
Query: 286 AFKKM 290
AF+ M
Sbjct: 407 AFRSM 411
>gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 100 bits (248), Expect = 2e-21
Identities = 84/305 (27%), Positives = 133/305 (43%), Gaps = 65/305 (21%)
Query: 33 TISIVGVLENLIVLLAVFKNKNLQA-PMYFFICSLAISDMLGSLYKILENILIIL----- 86
T+ VLENL+VL + +++L+ P Y FI SLA++D+LGS+ + I +
Sbjct: 125 TLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKD 184
Query: 87 -RNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMR 145
RN+ K G S S+ SL + A DRYI+I L Y IVT
Sbjct: 185 SRNVFLFKLGG-------------VTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRP 231
Query: 146 RTVVVLTVIWTFCTGTGITMV--------------IFSHHVPTVITF-TSLFPLMLVFIL 190
+ VV ++WT + + IF H T + F + ++L+FI
Sbjct: 232 KAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFI- 290
Query: 191 CLYVHMFLLARSHTRKISTLPRANMKGAI-------------------------TLTILL 225
+Y +M++L ++H+ + + R K I TL ++L
Sbjct: 291 -VYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLIL 349
Query: 226 GVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRD 285
V I CW P + ++ F N ++F ML + N+ ++P IYA RS +LR
Sbjct: 350 VVLIICWGPLLAIMVYDVFGKMN---KLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRH 406
Query: 286 AFKKM 290
AF+ M
Sbjct: 407 AFRSM 411
>gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens]
Length = 439
Score = 100 bits (248), Expect = 2e-21
Identities = 84/305 (27%), Positives = 133/305 (43%), Gaps = 65/305 (21%)
Query: 33 TISIVGVLENLIVLLAVFKNKNLQA-PMYFFICSLAISDMLGSLYKILENILIIL----- 86
T+ VLENL+VL + +++L+ P Y FI SLA++D+LGS+ + I +
Sbjct: 92 TLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKD 151
Query: 87 -RNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMR 145
RN+ K G S S+ SL + A DRYI+I L Y IVT
Sbjct: 152 SRNVFLFKLGG-------------VTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRP 198
Query: 146 RTVVVLTVIWTFCTGTGITMV--------------IFSHHVPTVITF-TSLFPLMLVFIL 190
+ VV ++WT + + IF H T + F + ++L+FI
Sbjct: 199 KAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFI- 257
Query: 191 CLYVHMFLLARSHTRKISTLPRANMKGAI-------------------------TLTILL 225
+Y +M++L ++H+ + + R K I TL ++L
Sbjct: 258 -VYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLIL 316
Query: 226 GVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRD 285
V I CW P + ++ F N ++F ML + N+ ++P IYA RS +LR
Sbjct: 317 VVLIICWGPLLAIMVYDVFGKMN---KLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRH 373
Query: 286 AFKKM 290
AF+ M
Sbjct: 374 AFRSM 378
>gi|38788193 sphingosine-1-phosphate receptor 3 [Homo sapiens]
Length = 378
Score = 98.6 bits (244), Expect = 6e-21
Identities = 83/282 (29%), Positives = 139/282 (49%), Gaps = 33/282 (11%)
Query: 30 IFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDML-GSLYKILENILIILRN 88
+F I VLENL+VL+A++KN MYFFI +LA+ D+L G YK+ NIL+ +
Sbjct: 45 LFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKV--NILMSGKK 102
Query: 89 MGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTV 148
L P F S+FV +L S SL IA +R++T+ +R + R
Sbjct: 103 TFSLSPTVWFLREG-----SMFV-ALGASTCSLLAIAIERHLTMI-KMRPYDANKRHRVF 155
Query: 149 VVLTVIWTFCTGTGITMVI---FSHHVPTVITF------------TSLFPLMLVFILCLY 193
+++ + W G ++ H++P T S+F +LV I+ LY
Sbjct: 156 LLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILY 215
Query: 194 VHMFLLARSHTRKISTLPRANMKGAI--TLTILLGVFIFCWAPFVLHVLLMTFCPSNPYC 251
++ L +S +RK++ + A+ T+ I++ VFI CW+P + L+ C
Sbjct: 216 ARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQ--- 272
Query: 252 ACYMSLFQVNGMLIMC--NAVIDPFIYAFRSPELRDAFKKMI 291
AC + LF+ +++ N+ ++P IY S E+R AF +++
Sbjct: 273 ACPI-LFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLV 313
>gi|4885325 G protein-coupled receptor 3 [Homo sapiens]
Length = 330
Score = 98.6 bits (244), Expect = 6e-21
Identities = 75/275 (27%), Positives = 131/275 (47%), Gaps = 39/275 (14%)
Query: 41 ENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFET 100
EN +V+ + +APM+ + SLA++D+L L +L + GS E
Sbjct: 57 ENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAAVFCI--------GSAEM 108
Query: 101 TADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTG 160
+ ++ + ++ SI SL I DRY+++++AL Y+S T+ RT V+L ++W G
Sbjct: 109 SL--VLVGVLAMAFTASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWGGALG 166
Query: 161 TGITMVIFSHHVPTVITFTSLFPL------------MLVF--ILCLYVHMFLLARSHTRK 206
G+ V+ + + + T ++PL +VF +L LY + + H ++
Sbjct: 167 LGLLPVLAWNCLDGLTTCGVVYPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQ 226
Query: 207 IS----TLPR----ANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLF 258
I+ LP A KG TL ++LG F CW PF ++ LL +P Y++L
Sbjct: 227 IALQRHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVYCLLGD--AHSPPLYTYLTLL 284
Query: 259 QVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFC 293
N++I+P IYAFR+ +++ + C
Sbjct: 285 PAT-----YNSMINPIIYAFRNQDVQKVLWAVCCC 314
>gi|134244587 endothelial differentiation, sphingolipid
G-protein-coupled receptor, 5 [Homo sapiens]
Length = 353
Score = 92.0 bits (227), Expect = 5e-19
Identities = 82/280 (29%), Positives = 135/280 (48%), Gaps = 43/280 (15%)
Query: 39 VLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENIL---IILRNMGYLKPR 95
V+ENL+VL+AV +N + MY F+ +LA SD+L + + +L + LR L P
Sbjct: 48 VVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLR----LTPV 103
Query: 96 GSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVV----- 150
F I +L S+FSL IA +R++ I Y S + R +++
Sbjct: 104 QWFAREGSAFI------TLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWL 157
Query: 151 -------LTVIWTFCTG-----TGITMVIFSHHVPTVITFTSLFPLMLVFILCLYVHMFL 198
L ++ C G + + + H+V V+T +F ++L+ I+ LYV ++
Sbjct: 158 ISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVT---IFSIILLAIVALYVRIYC 214
Query: 199 LAR-SHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMS- 256
+ R SH + A +K T+TI+LGVFI CW P +LL CP + Y +
Sbjct: 215 VVRSSHADMAAPQTLALLK---TVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAH 271
Query: 257 -LFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSR 295
F V+ + N++++P IY +RS +LR + + C R
Sbjct: 272 YFFAVSTL----NSLLNPVIYTWRSRDLRREVLRPLQCWR 307
>gi|5174593 melatonin receptor 1A [Homo sapiens]
Length = 350
Score = 89.0 bits (219), Expect = 5e-18
Identities = 69/287 (24%), Positives = 135/287 (47%), Gaps = 35/287 (12%)
Query: 30 IFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYK---ILENILIIL 86
+ FTI +V +L NL+V+L+V++NK L+ F+ SLA++D++ ++Y +L +I
Sbjct: 34 LIFTI-VVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNG 92
Query: 87 RNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRR 146
N+GYL + + L LS++GSIF+++ IA +RY I H+L+Y + + +
Sbjct: 93 WNLGYLHCQ---------VSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKN 143
Query: 147 TVVVLTVIWTFC---------TGT----------GITMVIFSHHVPTVITFTSLFPLMLV 187
++ + +IW GT + S + V+ F L P+++V
Sbjct: 144 SLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIV 203
Query: 188 FILCLYVHMFLLARSHTRKISTLPR---ANMKGAITLTILLGVFIFCWAPFVLHVLLMTF 244
L + + +L K P+ + + +T+ ++ +F CWAP L +
Sbjct: 204 IFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVAS 263
Query: 245 CPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMI 291
P++ LF + + N+ ++ IY + R ++++I
Sbjct: 264 DPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRII 310
>gi|4501951 adenosine A2b receptor [Homo sapiens]
Length = 332
Score = 89.0 bits (219), Expect = 5e-18
Identities = 88/311 (28%), Positives = 139/311 (44%), Gaps = 67/311 (21%)
Query: 34 ISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLK 93
I+ + V N++V AV LQ P +F+ SLA +D+ L+ I I I L
Sbjct: 17 IAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISL------- 69
Query: 94 PRGSFETTADDIIDSLFVLSLL-GSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLT 152
G + + FVL L SIFSL +A DRY+ I LRY S+VT R V+
Sbjct: 70 --GFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIA 127
Query: 153 VIWTFCTGTGIT------------------------------MVIFSHHVP-TVITFTSL 181
V+W G G+T +F + VP + + + +
Sbjct: 128 VLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNF 187
Query: 182 FPLML---VFILCLYVHMFLLA---------RSHTRKISTLPRANMKGAITLTILLGVFI 229
F +L + +L +Y+ +FL+A H+R +TL R + A +L +++G+F
Sbjct: 188 FGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSR--TTLQR-EIHAAKSLAMIVGIFA 244
Query: 230 FCWAPFVLHVLLMTFCPSN----PYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRD 285
CW P + F P+ P A M++ +L N+V++P +YA+R+ + R
Sbjct: 245 LCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAI-----LLSHANSVVNPIVYAYRNRDFRY 299
Query: 286 AFKKMIFCSRY 296
F K+I SRY
Sbjct: 300 TFHKII--SRY 308
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 88.2 bits (217), Expect = 8e-18
Identities = 84/347 (24%), Positives = 151/347 (43%), Gaps = 75/347 (21%)
Query: 11 INNTARNNSDCPRVVLPEEIFFTISI---------VGVLENLIVLLAVFKNKNLQAPMYF 61
++ A ++S+C + P I I + GVL N++V+L+V +++L + ++
Sbjct: 4 LSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHY 63
Query: 62 FICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSL 121
+I +LA++D+L L + I +GY +F +I ++ VL SI L
Sbjct: 64 YIVNLAVADLL--LTSTVLPFSAIFEVLGYW----AFGRVFCNIWAAVDVLCCTASIMGL 117
Query: 122 SVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGI-------------TMVIF 168
+I+ DRYI + + LRY +IVT RR ++ L +W I +
Sbjct: 118 CIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQ 177
Query: 169 SHHVPTVITFTSL--FPLMLVFILCLYVHMFLLARSHTRKIST---------------LP 211
+ P + F++L F L L IL +Y ++++A+ +R + + +
Sbjct: 178 INEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIH 237
Query: 212 RAN---------------------------MKGAITLTILLGVFIFCWAPFVLHVLLMTF 244
R N K A TL I++G F+ CW PF L + + +F
Sbjct: 238 RKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSF 297
Query: 245 CPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMI 291
P ++F++ L N+ I+P IY S E + AF+ ++
Sbjct: 298 FPDFKPSE---TVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 88.2 bits (217), Expect = 8e-18
Identities = 84/347 (24%), Positives = 151/347 (43%), Gaps = 75/347 (21%)
Query: 11 INNTARNNSDCPRVVLPEEIFFTISI---------VGVLENLIVLLAVFKNKNLQAPMYF 61
++ A ++S+C + P I I + GVL N++V+L+V +++L + ++
Sbjct: 4 LSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHY 63
Query: 62 FICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSL 121
+I +LA++D+L L + I +GY +F +I ++ VL SI L
Sbjct: 64 YIVNLAVADLL--LTSTVLPFSAIFEVLGYW----AFGRVFCNIWAAVDVLCCTASIMGL 117
Query: 122 SVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGI-------------TMVIF 168
+I+ DRYI + + LRY +IVT RR ++ L +W I +
Sbjct: 118 CIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQ 177
Query: 169 SHHVPTVITFTSL--FPLMLVFILCLYVHMFLLARSHTRKIST---------------LP 211
+ P + F++L F L L IL +Y ++++A+ +R + + +
Sbjct: 178 INEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIH 237
Query: 212 RAN---------------------------MKGAITLTILLGVFIFCWAPFVLHVLLMTF 244
R N K A TL I++G F+ CW PF L + + +F
Sbjct: 238 RKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSF 297
Query: 245 CPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMI 291
P ++F++ L N+ I+P IY S E + AF+ ++
Sbjct: 298 FPDFKPSE---TVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 88.2 bits (217), Expect = 8e-18
Identities = 84/347 (24%), Positives = 151/347 (43%), Gaps = 75/347 (21%)
Query: 11 INNTARNNSDCPRVVLPEEIFFTISI---------VGVLENLIVLLAVFKNKNLQAPMYF 61
++ A ++S+C + P I I + GVL N++V+L+V +++L + ++
Sbjct: 4 LSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHY 63
Query: 62 FICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSL 121
+I +LA++D+L L + I +GY +F +I ++ VL SI L
Sbjct: 64 YIVNLAVADLL--LTSTVLPFSAIFEVLGYW----AFGRVFCNIWAAVDVLCCTASIMGL 117
Query: 122 SVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGI-------------TMVIF 168
+I+ DRYI + + LRY +IVT RR ++ L +W I +
Sbjct: 118 CIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQ 177
Query: 169 SHHVPTVITFTSL--FPLMLVFILCLYVHMFLLARSHTRKIST---------------LP 211
+ P + F++L F L L IL +Y ++++A+ +R + + +
Sbjct: 178 INEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIH 237
Query: 212 RAN---------------------------MKGAITLTILLGVFIFCWAPFVLHVLLMTF 244
R N K A TL I++G F+ CW PF L + + +F
Sbjct: 238 RKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSF 297
Query: 245 CPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMI 291
P ++F++ L N+ I+P IY S E + AF+ ++
Sbjct: 298 FPDFKPSE---TVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 88.2 bits (217), Expect = 8e-18
Identities = 84/347 (24%), Positives = 151/347 (43%), Gaps = 75/347 (21%)
Query: 11 INNTARNNSDCPRVVLPEEIFFTISI---------VGVLENLIVLLAVFKNKNLQAPMYF 61
++ A ++S+C + P I I + GVL N++V+L+V +++L + ++
Sbjct: 4 LSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHY 63
Query: 62 FICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSL 121
+I +LA++D+L L + I +GY +F +I ++ VL SI L
Sbjct: 64 YIVNLAVADLL--LTSTVLPFSAIFEVLGYW----AFGRVFCNIWAAVDVLCCTASIMGL 117
Query: 122 SVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGI-------------TMVIF 168
+I+ DRYI + + LRY +IVT RR ++ L +W I +
Sbjct: 118 CIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQ 177
Query: 169 SHHVPTVITFTSL--FPLMLVFILCLYVHMFLLARSHTRKIST---------------LP 211
+ P + F++L F L L IL +Y ++++A+ +R + + +
Sbjct: 178 INEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIH 237
Query: 212 RAN---------------------------MKGAITLTILLGVFIFCWAPFVLHVLLMTF 244
R N K A TL I++G F+ CW PF L + + +F
Sbjct: 238 RKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSF 297
Query: 245 CPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMI 291
P ++F++ L N+ I+P IY S E + AF+ ++
Sbjct: 298 FPDFKPSE---TVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341
>gi|170932505 neuromedin U receptor 2 [Homo sapiens]
Length = 415
Score = 87.0 bits (214), Expect = 2e-17
Identities = 76/298 (25%), Positives = 131/298 (43%), Gaps = 42/298 (14%)
Query: 30 IFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNM 89
++ I +VGV+ N++V L + +++ ++ P +++ SLA+SD+L L + + + RN
Sbjct: 51 VYVPIFVVGVIGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNY 110
Query: 90 GYL-KPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTV 148
+L P G + TA LF SI S++ ++ +RY+ I H R T RR +
Sbjct: 111 PFLFGPVGCYFKTA------LFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRAL 164
Query: 149 VVLTVIWTFCT-----GTGITMVIFSHH-----VPTVITFTSLFP--------------- 183
+L ++W F T I + F + VP T T + P
Sbjct: 165 RILGIVWGFSVLFSLPNTSIHGIKFHYFPNGSLVPGSATCTVIKPMWIYNFIIQVTSFLF 224
Query: 184 --LMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAI------TLTILLGVFIFCWAPF 235
L + I LY M L + + AN++ L +L+ VF CWAPF
Sbjct: 225 YLLPMTVISVLYYLMALRLKKDKSLEADEGNANIQRPCRKSVNKMLFVLVLVFAICWAPF 284
Query: 236 VLHVLLMTFCP--SNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMI 291
+ L +F S A + + V+G+ ++ ++P IY S + AF+ +I
Sbjct: 285 HIDRLFFSFVEEWSESLAAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQAAFQNVI 342
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 86.3 bits (212), Expect = 3e-17
Identities = 92/353 (26%), Positives = 156/353 (44%), Gaps = 88/353 (24%)
Query: 13 NTARNNSDCPRVVLPEEI--------FFTISIVGVLENLIVLLAVFKNKNLQAPMYFFIC 64
N +NS P++ + I F +IVG N++V+L+V N++L+ P +FI
Sbjct: 29 NQTSSNSTLPQLDITRAISVGLVLGAFILFAIVG---NILVILSVACNRHLRTPTNYFIV 85
Query: 65 SLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVI 124
+LA++D+L S + +L L +GY F DI ++ VL SI SL I
Sbjct: 86 NLAMADLLLS-FTVLP-FSAALEVLGYWVLGRIF----CDIWAAVDVLCCTASILSLCAI 139
Query: 125 AADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVI-------------FSHH 171
+ DRYI + ++L+Y ++VT R+ ++ L +W T I ++
Sbjct: 140 SIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTE 199
Query: 172 VPTVITFTSL--FPLMLVFILCLYVHMFLLARSHTRKIS-------------TL------ 210
P F+SL F + L IL +Y ++++A+ T+ + TL
Sbjct: 200 EPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKN 259
Query: 211 ---------------PRANM-----------KGAITLTILLGVFIFCWAPFVLHV----L 240
PR+++ K A TL I++G+FI CW PF + + L
Sbjct: 260 FHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSL 319
Query: 241 LMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFC 293
T P + ++F+V L N+ ++P IY S E + AF +++ C
Sbjct: 320 FSTLKPPD-------AVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGC 365
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 84.3 bits (207), Expect = 1e-16
Identities = 76/321 (23%), Positives = 137/321 (42%), Gaps = 72/321 (22%)
Query: 36 IVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPR 95
++ V NL+V+L+V N++LQ +FI +LA++D+L L + + +G+
Sbjct: 108 LMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLL--LSATVLPFSATMEVLGFW--- 162
Query: 96 GSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIW 155
+F D+ ++ VL SI SL I+ DRY+ + H+L+Y +I+T R+ +L ++W
Sbjct: 163 -AFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLW 221
Query: 156 TFCTGTGITMVI-FSHHVP--------------TVITFTSLFPLMLVFILCLYVHMFLLA 200
+ ++ + VP V + F L + I+ +Y ++++A
Sbjct: 222 VVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVA 281
Query: 201 RSHTRKI------------STLPRANMKGAI----------------------------- 219
RS TR + + R + +GA
Sbjct: 282 RSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFS 341
Query: 220 -------TLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVID 272
TL I++GVF+ CW PF + L + P +F+V L N+ ++
Sbjct: 342 REKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQ---LKPSEGVFKVIFWLGYFNSCVN 398
Query: 273 PFIYAFRSPELRDAFKKMIFC 293
P IY S E + AF +++ C
Sbjct: 399 PLIYPCSSREFKRAFLRLLRC 419
>gi|4885341 G protein-coupled receptor 6 [Homo sapiens]
Length = 362
Score = 82.0 bits (201), Expect = 6e-16
Identities = 69/268 (25%), Positives = 117/268 (43%), Gaps = 39/268 (14%)
Query: 41 ENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFET 100
EN +V+ + L+ PM+ + SLA +D+L IL + YL P
Sbjct: 89 ENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVF------QYLVP----SE 138
Query: 101 TADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTG 160
T + V S S+ SL I DRY+++++AL Y+S T+ ++L WT G
Sbjct: 139 TVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLG 198
Query: 161 TGITMVIFSHHVPT--------------VITFTSLFPLMLVFILCLYVHMFLLARSHTRK 206
G+ V+ + + V ++ F ++ +L LYV + + H +
Sbjct: 199 LGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQ 258
Query: 207 ISTLPR--------ANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLF 258
I+ A KG TL ++LG F W PF ++ ++ + +P Y +L
Sbjct: 259 IALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSH--EDPAVYTYATLL 316
Query: 259 QVNGMLIMCNAVIDPFIYAFRSPELRDA 286
N++I+P IYAFR+ E++ A
Sbjct: 317 PAT-----YNSMINPIIYAFRNQEIQRA 339
>gi|7305013 lysophosphatidic acid receptor 2 [Homo sapiens]
Length = 351
Score = 81.3 bits (199), Expect = 1e-15
Identities = 70/296 (23%), Positives = 136/296 (45%), Gaps = 35/296 (11%)
Query: 22 PRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILEN 81
P+ V+ + T+S++ +L NL+V+ A+ N+ P+Y+ + +LA +D+ +
Sbjct: 30 PKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGV-----A 84
Query: 82 ILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSI 141
L ++ + G R S E + L SL S+ +L IA +R+ ++ A++ HS
Sbjct: 85 YLFLMFHTGPRTARLSLEGWF--LRQGLLDTSLTASVATLLAIAVERHRSVM-AVQLHSR 141
Query: 142 VTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTSLFPL-------------MLVF 188
+ R V+++ +W G G+ H + + + + PL +LVF
Sbjct: 142 LPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVF 201
Query: 189 IL--CLYVHMFLLARSHTRK----ISTLPR---ANMKGAITLTILLGVFIFCWAPFVLHV 239
+L +Y +F R ++ +S PR + T+ I+LG F+ CW P + +
Sbjct: 202 LLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVL 261
Query: 240 LLMTF-CPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCS 294
LL C S A +L N++++ +Y+ R E+R F++++ C+
Sbjct: 262 LLDGLGCESCNVLAVEKYFL----LLAEANSLVNAAVYSCRDAEMRRTFRRLLCCA 313
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.334 0.144 0.451
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,630,782
Number of Sequences: 37866
Number of extensions: 370329
Number of successful extensions: 2972
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 569
Number of HSP's successfully gapped in prelim test: 163
Number of HSP's that attempted gapping in prelim test: 1328
Number of HSP's gapped (non-prelim): 1013
length of query: 297
length of database: 18,247,518
effective HSP length: 102
effective length of query: 195
effective length of database: 14,385,186
effective search space: 2805111270
effective search space used: 2805111270
T: 11
A: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 39 (21.6 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.