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Search of human proteins with 4504237
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens]
(666 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens] 1397 0.0
gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens] 1359 0.0
gi|225637524 semaphorin 7A isoform 3 [Homo sapiens] 1053 0.0
gi|39777610 semaphorin 4B precursor [Homo sapiens] 233 4e-61
gi|39777608 semaphorin 4B precursor [Homo sapiens] 233 4e-61
gi|5174673 semaphorin 3A precursor [Homo sapiens] 228 1e-59
gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens] 218 1e-56
gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens] 218 2e-56
gi|5454048 semaphorin 3C [Homo sapiens] 212 1e-54
gi|188497703 semaphorin 3F [Homo sapiens] 197 3e-50
gi|6912650 semaphorin 3E [Homo sapiens] 196 4e-50
gi|214010218 semaphorin 4D isoform 1 [Homo sapiens] 194 2e-49
gi|41406086 semaphorin 3D [Homo sapiens] 190 4e-48
gi|214010220 semaphorin 4D isoform 2 [Homo sapiens] 190 4e-48
gi|9910362 semaphorin sem2 [Homo sapiens] 181 1e-45
gi|19923279 semaphorin W [Homo sapiens] 180 4e-45
gi|28872814 semaphorin 4G [Homo sapiens] 173 4e-43
gi|157388902 semaphorin 4C [Homo sapiens] 165 1e-40
gi|21361914 semaphorin B [Homo sapiens] 164 2e-40
gi|11991660 sema domain, transmembrane domain (TM), and cytoplas... 147 2e-35
gi|147904700 semaphorin 5A [Homo sapiens] 139 6e-33
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens] 137 3e-32
gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens] 134 3e-31
gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens] 134 3e-31
gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens] 134 3e-31
gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens] 134 3e-31
gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens] 134 3e-31
gi|16306552 semaphorin Y [Homo sapiens] 131 2e-30
gi|19718780 semaphorin 6B precursor [Homo sapiens] 123 5e-28
gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens] 96 1e-19
>gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens]
Length = 666
Score = 1397 bits (3615), Expect = 0.0
Identities = 666/666 (100%), Positives = 666/666 (100%)
Query: 1 MTPPPPGRAAPSAPRARVPGPPARLGLPLRLRLLLLLWAAAASAQGHLRSGPRIFAVWKG 60
MTPPPPGRAAPSAPRARVPGPPARLGLPLRLRLLLLLWAAAASAQGHLRSGPRIFAVWKG
Sbjct: 1 MTPPPPGRAAPSAPRARVPGPPARLGLPLRLRLLLLLWAAAASAQGHLRSGPRIFAVWKG 60
Query: 61 HVGQDRVDFGQTEPHTVLFHEPGSSSVWVGGRGKVYLFDFPEGKNASVRTVNIGSTKGSC 120
HVGQDRVDFGQTEPHTVLFHEPGSSSVWVGGRGKVYLFDFPEGKNASVRTVNIGSTKGSC
Sbjct: 61 HVGQDRVDFGQTEPHTVLFHEPGSSSVWVGGRGKVYLFDFPEGKNASVRTVNIGSTKGSC 120
Query: 121 LDKRDCENYITLLERRSEGLLACGTNARHPSCWNLVNGTVVPLGEMRGYAPFSPDENSLV 180
LDKRDCENYITLLERRSEGLLACGTNARHPSCWNLVNGTVVPLGEMRGYAPFSPDENSLV
Sbjct: 121 LDKRDCENYITLLERRSEGLLACGTNARHPSCWNLVNGTVVPLGEMRGYAPFSPDENSLV 180
Query: 181 LFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDDKI 240
LFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDDKI
Sbjct: 181 LFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDDKI 240
Query: 241 YYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATNKNF 300
YYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATNKNF
Sbjct: 241 YYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATNKNF 300
Query: 301 NRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCVYSLGDIDKVFRTSSLKGYHSSLPN 360
NRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCVYSLGDIDKVFRTSSLKGYHSSLPN
Sbjct: 301 NRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCVYSLGDIDKVFRTSSLKGYHSSLPN 360
Query: 361 PRPGKCLPDQQPIPTETFQVADRHPEVAQRVEPMGPLKTPLFHSKYHYQKVAVHRMQASH 420
PRPGKCLPDQQPIPTETFQVADRHPEVAQRVEPMGPLKTPLFHSKYHYQKVAVHRMQASH
Sbjct: 361 PRPGKCLPDQQPIPTETFQVADRHPEVAQRVEPMGPLKTPLFHSKYHYQKVAVHRMQASH 420
Query: 421 GETFHVLYLTTDRGTIHKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVS 480
GETFHVLYLTTDRGTIHKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVS
Sbjct: 421 GETFHVLYLTTDRGTIHKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVS 480
Query: 481 SQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQGRCISIYSSERSVLQSINPAEPHKE 540
SQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQGRCISIYSSERSVLQSINPAEPHKE
Sbjct: 481 SQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQGRCISIYSSERSVLQSINPAEPHKE 540
Query: 541 CPNPKPDKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFI 600
CPNPKPDKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFI
Sbjct: 541 CPNPKPDKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFI 600
Query: 601 ENLTAQQYGHYFCEAQEGSYFREAQHWQLLPEDGIMAEHLLGHACALAASLWLGVLPTLT 660
ENLTAQQYGHYFCEAQEGSYFREAQHWQLLPEDGIMAEHLLGHACALAASLWLGVLPTLT
Sbjct: 601 ENLTAQQYGHYFCEAQEGSYFREAQHWQLLPEDGIMAEHLLGHACALAASLWLGVLPTLT 660
Query: 661 LGLLVH 666
LGLLVH
Sbjct: 661 LGLLVH 666
>gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens]
Length = 652
Score = 1359 bits (3517), Expect = 0.0
Identities = 652/666 (97%), Positives = 652/666 (97%), Gaps = 14/666 (2%)
Query: 1 MTPPPPGRAAPSAPRARVPGPPARLGLPLRLRLLLLLWAAAASAQGHLRSGPRIFAVWKG 60
MTPPPPGRAAPSAPRARVPGPPARLGLPLRLRLLLLLWAAAASAQGHLRSGPRIFAVWKG
Sbjct: 1 MTPPPPGRAAPSAPRARVPGPPARLGLPLRLRLLLLLWAAAASAQGHLRSGPRIFAVWKG 60
Query: 61 HVGQDRVDFGQTEPHTVLFHEPGSSSVWVGGRGKVYLFDFPEGKNASVRTVNIGSTKGSC 120
HVGQDRVDFGQTEPHTVLFHEPGSSSVWVGGRGKVYLFDFPEGKNASVRT
Sbjct: 61 HVGQDRVDFGQTEPHTVLFHEPGSSSVWVGGRGKVYLFDFPEGKNASVRT---------- 110
Query: 121 LDKRDCENYITLLERRSEGLLACGTNARHPSCWNLVNGTVVPLGEMRGYAPFSPDENSLV 180
DCENYITLLERRSEGLLACGTNARHPSCWNLVNGTVVPLGEMRGYAPFSPDENSLV
Sbjct: 111 ----DCENYITLLERRSEGLLACGTNARHPSCWNLVNGTVVPLGEMRGYAPFSPDENSLV 166
Query: 181 LFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDDKI 240
LFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDDKI
Sbjct: 167 LFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDDKI 226
Query: 241 YYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATNKNF 300
YYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATNKNF
Sbjct: 227 YYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATNKNF 286
Query: 301 NRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCVYSLGDIDKVFRTSSLKGYHSSLPN 360
NRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCVYSLGDIDKVFRTSSLKGYHSSLPN
Sbjct: 287 NRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCVYSLGDIDKVFRTSSLKGYHSSLPN 346
Query: 361 PRPGKCLPDQQPIPTETFQVADRHPEVAQRVEPMGPLKTPLFHSKYHYQKVAVHRMQASH 420
PRPGKCLPDQQPIPTETFQVADRHPEVAQRVEPMGPLKTPLFHSKYHYQKVAVHRMQASH
Sbjct: 347 PRPGKCLPDQQPIPTETFQVADRHPEVAQRVEPMGPLKTPLFHSKYHYQKVAVHRMQASH 406
Query: 421 GETFHVLYLTTDRGTIHKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVS 480
GETFHVLYLTTDRGTIHKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVS
Sbjct: 407 GETFHVLYLTTDRGTIHKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVS 466
Query: 481 SQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQGRCISIYSSERSVLQSINPAEPHKE 540
SQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQGRCISIYSSERSVLQSINPAEPHKE
Sbjct: 467 SQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQGRCISIYSSERSVLQSINPAEPHKE 526
Query: 541 CPNPKPDKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFI 600
CPNPKPDKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFI
Sbjct: 527 CPNPKPDKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFI 586
Query: 601 ENLTAQQYGHYFCEAQEGSYFREAQHWQLLPEDGIMAEHLLGHACALAASLWLGVLPTLT 660
ENLTAQQYGHYFCEAQEGSYFREAQHWQLLPEDGIMAEHLLGHACALAASLWLGVLPTLT
Sbjct: 587 ENLTAQQYGHYFCEAQEGSYFREAQHWQLLPEDGIMAEHLLGHACALAASLWLGVLPTLT 646
Query: 661 LGLLVH 666
LGLLVH
Sbjct: 647 LGLLVH 652
>gi|225637524 semaphorin 7A isoform 3 [Homo sapiens]
Length = 501
Score = 1053 bits (2724), Expect = 0.0
Identities = 501/501 (100%), Positives = 501/501 (100%)
Query: 166 MRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFI 225
MRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFI
Sbjct: 1 MRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFI 60
Query: 226 KATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFL 285
KATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFL
Sbjct: 61 KATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFL 120
Query: 286 KAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCVYSLGDIDKV 345
KAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCVYSLGDIDKV
Sbjct: 121 KAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCVYSLGDIDKV 180
Query: 346 FRTSSLKGYHSSLPNPRPGKCLPDQQPIPTETFQVADRHPEVAQRVEPMGPLKTPLFHSK 405
FRTSSLKGYHSSLPNPRPGKCLPDQQPIPTETFQVADRHPEVAQRVEPMGPLKTPLFHSK
Sbjct: 181 FRTSSLKGYHSSLPNPRPGKCLPDQQPIPTETFQVADRHPEVAQRVEPMGPLKTPLFHSK 240
Query: 406 YHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGEQEHSFAFNIMEIQPFRRAAAI 465
YHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGEQEHSFAFNIMEIQPFRRAAAI
Sbjct: 241 YHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGEQEHSFAFNIMEIQPFRRAAAI 300
Query: 466 QTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQGRCISIYSSE 525
QTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQGRCISIYSSE
Sbjct: 301 QTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQGRCISIYSSE 360
Query: 526 RSVLQSINPAEPHKECPNPKPDKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQ 585
RSVLQSINPAEPHKECPNPKPDKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQ
Sbjct: 361 RSVLQSINPAEPHKECPNPKPDKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQ 420
Query: 586 SCEPGHQSPNCILFIENLTAQQYGHYFCEAQEGSYFREAQHWQLLPEDGIMAEHLLGHAC 645
SCEPGHQSPNCILFIENLTAQQYGHYFCEAQEGSYFREAQHWQLLPEDGIMAEHLLGHAC
Sbjct: 421 SCEPGHQSPNCILFIENLTAQQYGHYFCEAQEGSYFREAQHWQLLPEDGIMAEHLLGHAC 480
Query: 646 ALAASLWLGVLPTLTLGLLVH 666
ALAASLWLGVLPTLTLGLLVH
Sbjct: 481 ALAASLWLGVLPTLTLGLLVH 501
>gi|39777610 semaphorin 4B precursor [Homo sapiens]
Length = 837
Score = 233 bits (594), Expect = 4e-61
Identities = 211/694 (30%), Positives = 302/694 (43%), Gaps = 97/694 (13%)
Query: 12 SAPRARVPGPPARLGLPLRLRLLLLL--------WAAAASAQGHLRSGPRIFAVWKGHVG 63
+AP +P P PL L LLLLL WA + L S R F
Sbjct: 13 AAPWGALPPRP-----PLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFL------- 60
Query: 64 QDRVDFGQTEPHTVLFHEPGSSSVWVGGRGKVYLFD-----FPEGKNASVRTVNIGSTKG 118
R + +T L +++VG R ++ P G+ + K
Sbjct: 61 --RFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQ 118
Query: 119 SCLDK-----RDCENYIT-LLERRSEGLLACGTNARHPSCW--NLVNGTV-------VPL 163
C K RDC+NYI LL L CGT A P C N+ N T+ V L
Sbjct: 119 QCSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLL 178
Query: 164 GEMRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTV--MQN 221
+ +G PF P+ S L E+Y T + G P R + T ++ +Q+
Sbjct: 179 EDGKGRCPFDPNFKSTALVVDGELY-TGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQD 237
Query: 222 PQFIKATIVHQD----QAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLS 277
P F+ + + + Q DDKIY+FF E + VSR+A++C+GD+GGE L
Sbjct: 238 PAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQ 297
Query: 278 VSKWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY-----S 332
+W +FLKA L+CS FN LQDVF L WRDT YGVF++ W+ S
Sbjct: 298 -QRWTSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGS 356
Query: 333 AVCVYSLGDIDKVF---------RTSSLKGYHSSLPNPRPGKCLPD--QQPIPTETFQVA 381
AVCV+++ D+ +VF T +P PRPG C+ + ++ + Q+
Sbjct: 357 AVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLP 416
Query: 382 DRHPEVAQ---RVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHK 438
DR + ++ + L + YQ+VAVHR+ H T+ VL+L T G +HK
Sbjct: 417 DRVLNFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLH-HTYDVLFLGTGDGRLHK 475
Query: 439 VVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGG 498
V G + H I E+Q F +Q + LD R LY +S V QVP+ C +Y
Sbjct: 476 AVSVGPRVHI----IEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLY-R 530
Query: 499 GCHGCLMSRDPYCGWDQGRC--ISIYSSE---RSVLQSINPAEPHKEC-------PNPKP 546
C CL++RDPYC W C +S+Y + R +Q I A C P+ P
Sbjct: 531 SCGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVP 590
Query: 547 -DKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHK---ENVEQSCEPGHQSPNCILFIEN 602
+ P ++V PN+ L+CP+ S AT W N SC H P L +
Sbjct: 591 TGEKPCEQVQFQPNTVNTLACPLLSNLATRLWLRNGAPVNASASC---HVLPTGDLLL-- 645
Query: 603 LTAQQYGHYFC-EAQEGSYFREAQHWQLLPEDGI 635
+ QQ G + C +EG A + + EDG+
Sbjct: 646 VGTQQLGEFQCWSLEEGFQQLVASYCPEVVEDGV 679
>gi|39777608 semaphorin 4B precursor [Homo sapiens]
Length = 837
Score = 233 bits (594), Expect = 4e-61
Identities = 211/694 (30%), Positives = 302/694 (43%), Gaps = 97/694 (13%)
Query: 12 SAPRARVPGPPARLGLPLRLRLLLLL--------WAAAASAQGHLRSGPRIFAVWKGHVG 63
+AP +P P PL L LLLLL WA + L S R F
Sbjct: 13 AAPWGALPPRP-----PLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFL------- 60
Query: 64 QDRVDFGQTEPHTVLFHEPGSSSVWVGGRGKVYLFD-----FPEGKNASVRTVNIGSTKG 118
R + +T L +++VG R ++ P G+ + K
Sbjct: 61 --RFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQ 118
Query: 119 SCLDK-----RDCENYIT-LLERRSEGLLACGTNARHPSCW--NLVNGTV-------VPL 163
C K RDC+NYI LL L CGT A P C N+ N T+ V L
Sbjct: 119 QCSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLL 178
Query: 164 GEMRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTV--MQN 221
+ +G PF P+ S L E+Y T + G P R + T ++ +Q+
Sbjct: 179 EDGKGRCPFDPNFKSTALVVDGELY-TGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQD 237
Query: 222 PQFIKATIVHQD----QAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLS 277
P F+ + + + Q DDKIY+FF E + VSR+A++C+GD+GGE L
Sbjct: 238 PAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQ 297
Query: 278 VSKWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY-----S 332
+W +FLKA L+CS FN LQDVF L WRDT YGVF++ W+ S
Sbjct: 298 -QRWTSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGS 356
Query: 333 AVCVYSLGDIDKVF---------RTSSLKGYHSSLPNPRPGKCLPD--QQPIPTETFQVA 381
AVCV+++ D+ +VF T +P PRPG C+ + ++ + Q+
Sbjct: 357 AVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLP 416
Query: 382 DRHPEVAQ---RVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHK 438
DR + ++ + L + YQ+VAVHR+ H T+ VL+L T G +HK
Sbjct: 417 DRVLNFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLH-HTYDVLFLGTGDGRLHK 475
Query: 439 VVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGG 498
V G + H I E+Q F +Q + LD R LY +S V QVP+ C +Y
Sbjct: 476 AVSVGPRVHI----IEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLY-R 530
Query: 499 GCHGCLMSRDPYCGWDQGRC--ISIYSSE---RSVLQSINPAEPHKEC-------PNPKP 546
C CL++RDPYC W C +S+Y + R +Q I A C P+ P
Sbjct: 531 SCGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVP 590
Query: 547 -DKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHK---ENVEQSCEPGHQSPNCILFIEN 602
+ P ++V PN+ L+CP+ S AT W N SC H P L +
Sbjct: 591 TGEKPCEQVQFQPNTVNTLACPLLSNLATRLWLRNGAPVNASASC---HVLPTGDLLL-- 645
Query: 603 LTAQQYGHYFC-EAQEGSYFREAQHWQLLPEDGI 635
+ QQ G + C +EG A + + EDG+
Sbjct: 646 VGTQQLGEFQCWSLEEGFQQLVASYCPEVVEDGV 679
>gi|5174673 semaphorin 3A precursor [Homo sapiens]
Length = 771
Score = 228 bits (581), Expect = 1e-59
Identities = 189/664 (28%), Positives = 303/664 (45%), Gaps = 84/664 (12%)
Query: 32 RLLLLLWAAAASAQGHLRSG----PRIFAVWKGHVGQDRVDF-----GQTEPHTVLFHEP 82
R++ L W +A+ + ++G PR+ +K + + V + HT L E
Sbjct: 6 RIVCLFWGVLLTARANYQNGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEE 65
Query: 83 GSSSVWVGGRGKVYLFDFPEGKNASVRTVNIGSTK-------GSCLDKRDCENYITLLER 135
S ++VG + ++ FD K+ + T+ G + K +C N+I +L+
Sbjct: 66 -RSRLYVGAKDHIFSFDLVNIKDFQKIVWPVSYTRRDECKWAGKDILK-ECANFIKVLKA 123
Query: 136 RSEG-LLACGTNARHPSCWNLVNG-----TVVPLGEM-----RGYAPFSPDENSLVLFEG 184
++ L ACGT A HP C + G + L RG +P+ P + L
Sbjct: 124 YNQTHLYACGTGAFHPICTYIEIGHHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLID 183
Query: 185 DEVYSTIRKQEYNGKIPRFRRIRGESELYTSD---TVMQNPQFIKATIVHQ-DQAYDDKI 240
E+YS FR + + T + +P+FI A ++ + D DDK+
Sbjct: 184 GELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPKFISAHLISESDNPEDDKV 243
Query: 241 YYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATN--- 297
Y+FFRE+ D +R+ Q+C+ D GG SL V+KW TFLKA L+CS N
Sbjct: 244 YFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSL-VNKWTTFLKARLICSVPGPNGID 302
Query: 298 KNFNRLQDVFLL--PDPSGQWRDTRVYGVF---SNPWNYSAVCVYSLGDIDKVFR----- 347
+F+ LQDVFL+ DP ++ VYGVF SN + SAVC+YS+ D+ +VF
Sbjct: 303 THFDELQDVFLMNFKDP----KNPVVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAH 358
Query: 348 ----TSSLKGYHSSLPNPRPGKC-------LPDQQPIPTETFQVADRHPEVAQRVEPMGP 396
Y +P PRPG C + +P + A HP + V PM
Sbjct: 359 RDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNN 418
Query: 397 ----LKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVE-PGEQEHSFAF 451
+KT + Y + ++ V R+ A G+ + V+++ TD GT+ KVV P E +
Sbjct: 419 RPIVIKTDV---NYQFTQIVVDRVDAEDGQ-YDVMFIGTDVGTVLKVVSIPKETWYDLEE 474
Query: 452 NIME-IQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPY 510
++E + FR AI M L ++++LY+ S V+Q+PL C++YG C C ++RDPY
Sbjct: 475 VLLEEMTVFREPTAISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPY 534
Query: 511 CGWDQGRCISIY--SSERSVLQSINPAEPHKECPNPKPDK----APLQKVSL-APNSRYY 563
C WD C + + R+ Q I +P C + D +P +++ NS +
Sbjct: 535 CAWDGSACSRYFPTAKRRTRRQDIRNGDPLTHCSDLHHDNHHGHSPEERIIYGVENSSTF 594
Query: 564 LSCPMESRHATYSWRHKENVEQSCEPGHQSPNCI-----LFIENLTAQQYGHYFCEAQEG 618
L C +S+ A W+ + E+ E + I L + +L + G+Y C A E
Sbjct: 595 LECSPKSQRALVYWQFQRRNEERKEEIRVDDHIIRTDQGLLLRSLQQKDSGNYLCHAVEH 654
Query: 619 SYFR 622
+ +
Sbjct: 655 GFIQ 658
>gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]
Length = 748
Score = 218 bits (555), Expect = 1e-56
Identities = 172/565 (30%), Positives = 254/565 (44%), Gaps = 55/565 (9%)
Query: 125 DCENYITLLERRSEG-LLACGTNARHPSCWNLVNGTVVP----------LGEMRGYAPFS 173
+C N++ LL + LLACGT A HP+C + G + + +G +P+
Sbjct: 112 ECMNFVKLLHAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYD 171
Query: 174 PDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTS---DTVMQNPQFIKAT-I 229
P + + G+E+YS + FR + L T + P+F+K I
Sbjct: 172 PRHRAASVLVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWI 231
Query: 230 VHQDQAYDDKIYYFFREDNPDKNPE-APLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAM 288
+ DDKIY+FFRE + P L+VSRV Q+CR D GG+ SL V+KW TFLKA
Sbjct: 232 PESENPDDDKIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSL-VNKWTTFLKAR 290
Query: 289 LVCSDAAT--NKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNP--WNYSAVCVYSLGDIDK 344
LVCS + +F++LQDVFLL S R +Y VFS + SAVCVYS+ D+ +
Sbjct: 291 LVCSVPGVEGDTHFDQLQDVFLLS--SRDHRTPLLYAVFSTSSIFQGSAVCVYSMNDVRR 348
Query: 345 VFR---------TSSLKGYHSSLPNPRPGKC-------LPDQQPIPTETFQVADRHPEVA 388
F Y +P PRPG C + P + Q A HP +
Sbjct: 349 AFLGPFAHKEGPMHQWVSYQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMY 408
Query: 389 QRVEPMGPLKTPLF---HSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVE--PG 443
V P G PLF + Y + ++A R+ A+ G + VL++ TD GT+ KV+ G
Sbjct: 409 NSVLPTGG--RPLFLQVGANYTFTQIAADRVAAADGH-YDVLFIGTDVGTVLKVISVPKG 465
Query: 444 EQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGC 503
+ + + E+ F +AA+ +M + ++R +LYV+S+ V+Q+ L C +G C C
Sbjct: 466 SRPSAEGLLLEELHVFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTEC 525
Query: 504 LMSRDPYCGWDQGRCISIYSS--ERSVLQSINPAEPHKECPNPKPDKAPLQ-KVSLAPNS 560
++RDPYC WD C S R Q + +P C A L+ KV S
Sbjct: 526 CLARDPYCAWDGVACTRFQPSAKRRFRRQDVRNGDPSTLCSGDSSRPALLEHKVFGVEGS 585
Query: 561 RYYLSCPMESRHATYSWRHKE-----NVEQSCEPGHQSPNCILFIENLTAQQYGHYFCEA 615
+L C S A W + + + E + L + L + G Y C A
Sbjct: 586 SAFLECEPRSLQARVEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAA 645
Query: 616 QEGSYFREAQHWQLLPEDGIMAEHL 640
E + + + L AE L
Sbjct: 646 VEQGFTQPLRRLSLHVLSATQAERL 670
>gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens]
Length = 749
Score = 218 bits (554), Expect = 2e-56
Identities = 172/566 (30%), Positives = 254/566 (44%), Gaps = 56/566 (9%)
Query: 125 DCENYITLLERRSEG-LLACGTNARHPSCWNLVNGTVVP----------LGEMRGYAPFS 173
+C N++ LL + LLACGT A HP+C + G + + +G +P+
Sbjct: 112 ECMNFVKLLHAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYD 171
Query: 174 PDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTS---DTVMQNPQFIKAT-I 229
P + + G+E+YS + FR + L T + P+F+K I
Sbjct: 172 PRHRAASVLVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWI 231
Query: 230 VHQDQAYDDKIYYFFREDNPDKNPE-APLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAM 288
+ DDKIY+FFRE + P L+VSRV Q+CR D GG+ SL V+KW TFLKA
Sbjct: 232 PESENPDDDKIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSL-VNKWTTFLKAR 290
Query: 289 LVCSDAAT--NKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNP---WNYSAVCVYSLGDID 343
LVCS + +F++LQDVFLL S R +Y VFS + SAVCVYS+ D+
Sbjct: 291 LVCSVPGVEGDTHFDQLQDVFLLS--SRDHRTPLLYAVFSTSSSIFQGSAVCVYSMNDVR 348
Query: 344 KVFR---------TSSLKGYHSSLPNPRPGKC-------LPDQQPIPTETFQVADRHPEV 387
+ F Y +P PRPG C + P + Q A HP +
Sbjct: 349 RAFLGPFAHKEGPMHQWVSYQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLM 408
Query: 388 AQRVEPMGPLKTPLF---HSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVE--P 442
V P G PLF + Y + ++A R+ A+ G + VL++ TD GT+ KV+
Sbjct: 409 YNSVLPTGG--RPLFLQVGANYTFTQIAADRVAAADGH-YDVLFIGTDVGTVLKVISVPK 465
Query: 443 GEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHG 502
G + + + E+ F +AA+ +M + ++R +LYV+S+ V+Q+ L C +G C
Sbjct: 466 GSRPSAEGLLLEELHVFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTE 525
Query: 503 CLMSRDPYCGWDQGRCISIYSS--ERSVLQSINPAEPHKECPNPKPDKAPLQ-KVSLAPN 559
C ++RDPYC WD C S R Q + +P C A L+ KV
Sbjct: 526 CCLARDPYCAWDGVACTRFQPSAKRRFRRQDVRNGDPSTLCSGDSSRPALLEHKVFGVEG 585
Query: 560 SRYYLSCPMESRHATYSWRHKE-----NVEQSCEPGHQSPNCILFIENLTAQQYGHYFCE 614
S +L C S A W + + + E + L + L + G Y C
Sbjct: 586 SSAFLECEPRSLQARVEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCA 645
Query: 615 AQEGSYFREAQHWQLLPEDGIMAEHL 640
A E + + + L AE L
Sbjct: 646 AVEQGFTQPLRRLSLHVLSATQAERL 671
>gi|5454048 semaphorin 3C [Homo sapiens]
Length = 751
Score = 212 bits (539), Expect = 1e-54
Identities = 166/545 (30%), Positives = 253/545 (46%), Gaps = 56/545 (10%)
Query: 126 CENYITLLERRSEG-LLACGTNARHPSCWNLVNGT-----VVPLGEM----RGYAPFSPD 175
C N++ +++ + L CG+ A P C L G V + +G F+P+
Sbjct: 112 CGNFVRVIQTFNRTHLYVCGSGAFSPVCTYLNRGRRSEDQVFMIDSKCESGKGRCSFNPN 171
Query: 176 ENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYT---SDTVMQNPQFIKATIVHQ 232
N++ + +E++S + FR + + + T + + P F+ A ++
Sbjct: 172 VNTVSVMINEELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWLSEPMFVDAHVIPD 231
Query: 233 DQAYDD-KIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVC 291
+D K+Y+FF+E D N S +A++C D GG SL V+KW TFLKA LVC
Sbjct: 232 GTDPNDAKVYFFFKEKLTDNNRSTKQIHSMIARICPNDTGGLRSL-VNKWTTFLKARLVC 290
Query: 292 S---DAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVF---SNPWNYSAVCVYSLGDIDKV 345
S + +F+ L+DVFLL + R T VYG+F S+ + SAVCVY L DI V
Sbjct: 291 SVTDEDGPETHFDELEDVFLLETDNP--RTTLVYGIFTTSSSVFKGSAVCVYHLSDIQTV 348
Query: 346 FR---------TSSLKGYHSSLPNPRPGKC--------LPDQQPIPTETFQVADRHPEVA 388
F L Y +P PRPG C + + P + HP +
Sbjct: 349 FNGPFAHKEGPNHQLISYQGRIPYPRPGTCPGGAFTPNMRTTKEFPDDVVTFIRNHPLMY 408
Query: 389 QRVEPMGPLKTPLF---HSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVE-PGE 444
+ P+ K PL + Y Y K+AV R+ A+ G +HVL+L TDRGT+ KVV P
Sbjct: 409 NSIYPIH--KRPLIVRIGTDYKYTKIAVDRVNAADGR-YHVLFLGTDRGTVQKVVVLPTN 465
Query: 445 QEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCL 504
S + E++ F+ A I TM + +++++LYVSS VSQV L C +YG C C
Sbjct: 466 NSVSGELILEELEVFKNHAPITTMKISSKKQQLYVSSNEGVSQVSLHRCHIYGTACADCC 525
Query: 505 MSRDPYCGWDQGRCISIY--SSERSVLQSINPAEPHKECP--NPKPDKAPLQKVSL-APN 559
++RDPYC WD C Y RS Q + P +C N K + + V N
Sbjct: 526 LARDPYCAWDGHSCSRFYPTGKRRSRRQDVRHGNPLTQCRGFNLKAYRNAAEIVQYGVKN 585
Query: 560 SRYYLSCPMESRHATYSWRHKENVEQSCEPGHQ----SPNCILFIENLTAQQYGHYFCEA 615
+ +L C +S A+ W +++ ++ E + + L I ++ G Y C A
Sbjct: 586 NTTFLECAPKSPQASIKWLLQKDKDRRKEVKLNERIIATSQGLLIRSVQGSDQGLYHCIA 645
Query: 616 QEGSY 620
E S+
Sbjct: 646 TENSF 650
>gi|188497703 semaphorin 3F [Homo sapiens]
Length = 785
Score = 197 bits (501), Expect = 3e-50
Identities = 184/717 (25%), Positives = 300/717 (41%), Gaps = 119/717 (16%)
Query: 35 LLLWAAAASA-------QGHLRSGPRIFAVWKGHVGQDRVDFGQ----TEPHTVLFHEPG 83
LLLWA+ + Q HL + PR+ +K F T + +L +
Sbjct: 6 LLLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDED 65
Query: 84 SSSVWVGGRGKVYLFDFPEGKN--------ASVRTVNIGSTKGSCLDKRDCENYITLLER 135
++VG + V D + AS + + G ++ +C N++ L++
Sbjct: 66 HDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNG-ECGNFVRLIQP 124
Query: 136 RSEG-LLACGTNARHPSC-------------WN-----------LVNGTVVP-------- 162
+ L CGT A +P C W +G + P
Sbjct: 125 WNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQD 184
Query: 163 ---------LGEMRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELY 213
L +G P+ P ++ +E+Y+ + FR + ++ +
Sbjct: 185 YIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQTAMR 244
Query: 214 T---SDTVMQNPQFIKATIVHQD-QAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGD 269
T + + +P FI A ++ + DDK+Y+FFRE + + P++P +R+ ++C D
Sbjct: 245 TDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRERSAEA-PQSPAVYARIGRICLND 303
Query: 270 QGGESSLSVSKWNTFLKAMLVCS---DAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFS 326
GG L V+KW+TFLKA LVCS + +F+ LQDVF+ + R+ +Y VF+
Sbjct: 304 DGGHCCL-VNKWSTFLKARLVCSVPGEDGIETHFDELQDVFV--QQTQDVRNPVIYAVFT 360
Query: 327 NPWNY---SAVCVYSLGDIDKVFR---------TSSLKGYHSSLPNPRPGKC-------- 366
+ + SAVCVYS+ DI VF + +P PRPG C
Sbjct: 361 SSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPS 420
Query: 367 LPDQQPIPTETFQVADRHPEVAQRVEPMGPLKTPLF---HSKYHYQKVAVHRMQASHGET 423
+ + P E HP + Q V P+ + PL + Y +AV ++ A+ G
Sbjct: 421 MKSTKDYPDEVINFMRSHPLMYQAVYPLQ--RRPLVVRTGAPYRLTTIAVDQVDAADGR- 477
Query: 424 FHVLYLTTDRGTIHKVVE-PGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQ 482
+ VL+L TDRGT+ KV+ P + + + E++ F+ A ++TM++ ++R++LYV+S
Sbjct: 478 YEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTISSKRQQLYVASA 537
Query: 483 WEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQGRC--ISIYSSERSVLQSINPAEPHKE 540
V+ + L C+ YG C C ++RDPYC WD C + S RS Q + P ++
Sbjct: 538 VGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPIRQ 597
Query: 541 CP--NPKPDKAPLQKVSL-APNSRYYLSCPMESRHATYSWRHKENV-----EQSCEPGHQ 592
C N +K ++ V S +L C S AT W + + E E
Sbjct: 598 CRGFNSNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQRDPGDRRREIRAEDRFL 657
Query: 593 SPNCILFIENLTAQQYGHYFCEAQEGSYFREAQHWQLLPEDGIMAEHLLGHACALAA 649
L + L G Y C A E ++ QL H+LG AA
Sbjct: 658 RTEQGLLLRALQLSDRGLYSCTATENNFKHVVTRVQL---------HVLGRDAVHAA 705
>gi|6912650 semaphorin 3E [Homo sapiens]
Length = 775
Score = 196 bits (499), Expect = 4e-50
Identities = 179/657 (27%), Positives = 289/657 (43%), Gaps = 81/657 (12%)
Query: 34 LLLLWAAAASAQGHLRSGPRIFAVWKGHVGQDRVD-----FGQTEPHTVLFHEPGSSSVW 88
LL LW +A + PR+ K + +R FG + HT+L E ++
Sbjct: 16 LLELWTGGHTAD---TTHPRLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEY-QERLF 71
Query: 89 VGGRGKVYLFDFPEGKNASVRTVNIGSTK---GSCL----DKRDCENYITLLERRSEG-L 140
VGGR VY E + + ++ ST C+ D +C NY+ +L + L
Sbjct: 72 VGGRDLVYSLSL-ERISDGYKEIHWPSTALKMEECIMKGKDAGECANYVRVLHHYNRTHL 130
Query: 141 LACGTNARHPSCWNLVNGTVV--PLGEM--------RGYAPFSPDENSLVLFEGDEVYST 190
L CGT A P C + G + PL + RG PF P + + G E+++
Sbjct: 131 LTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSELFAG 190
Query: 191 IRKQEYNGKIPRFRRIRGESELYTS---DTVMQNPQFIKATIVHQDQAYDD-KIYYFFRE 246
+ ++ FR + + + T + +++ P+F+ + ++ ++ DD K+Y+FF E
Sbjct: 191 LYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKVYFFFTE 250
Query: 247 DNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATN---KNFNRL 303
+ A +RV +LC D GG+ L V+KW+TFLKA LVCS N F+ L
Sbjct: 251 KALEAENNAHAIYTRVGRLCVNDVGGQRIL-VNKWSTFLKARLVCSVPGMNGIDTYFDEL 309
Query: 304 QDVFLLPDPSGQWRDTRVYGVF---SNPWNYSAVCVYSLGDIDKVFRT--SSLKG----- 353
+DVFLLP + ++ ++G+F SN + A+CVY + I F + +G
Sbjct: 310 EDVFLLP--TRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHKEGPEYHW 367
Query: 354 --YHSSLPNPRPGKCLPD--------QQPIPTETFQVADRHPEVAQRVEPMGPLKTPLF- 402
Y +P PRPG C + P + + A HP + Q ++P K P+
Sbjct: 368 SVYEGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAH--KKPILV 425
Query: 403 --HSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGEQEHSFAFNIM--EIQP 458
KY+ +++AV R++A G+ + VL++ TD G + KV+ QE ++ E+Q
Sbjct: 426 KTDGKYNLKQIAVDRVEAEDGQ-YDVLFIGTDNGIVLKVITIYNQEMESMEEVILEELQI 484
Query: 459 FRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQGRC 518
F+ I +M + ++R++LY+ S V+QV C++YG C C ++RDPYC WD C
Sbjct: 485 FKDPVPIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAWDGISC 544
Query: 519 ISIY-----SSERSVLQSINPAEPHKEC-----PNPKPDKAPLQKVSLAPNSRYYLSCPM 568
Y + R Q + ++C DK N+ L C
Sbjct: 545 SRYYPTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKTEEHLAYGIENNSTLLECTP 604
Query: 569 ESRHATYSWRHKENVEQSCEPGHQSPNCI-----LFIENLTAQQYGHYFCEAQEGSY 620
S A W ++ E E + L L G YFC+ E S+
Sbjct: 605 RSLQAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFLRLHKSDAGTYFCQTVEHSF 661
>gi|214010218 semaphorin 4D isoform 1 [Homo sapiens]
Length = 862
Score = 194 bits (493), Expect = 2e-49
Identities = 167/616 (27%), Positives = 270/616 (43%), Gaps = 80/616 (12%)
Query: 66 RVDFGQTEPHTVLFHEPG------------SSSVWVGGRGKVYLFDFPE--GKNASVRTV 111
R+ + E H V FHEP ++++G R V+ + K V
Sbjct: 29 RITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWK 88
Query: 112 NIGSTKGSCLDK-----RDCENYITLLERRSE-GLLACGTNARHPSCWNLVNGTVVPLGE 165
K C +K +C NYI +L+ S L CGTNA P+C +L + LG+
Sbjct: 89 VSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGK 148
Query: 166 M---RGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTV--MQ 220
+G PF P + + E+YS + G P R S L T + +
Sbjct: 149 NEDGKGRCPFDPAHSYTSVMVDGELYSGT-SYNFLGSEPIISRNSSHSPLRTEYAIPWLN 207
Query: 221 NPQFIKATIVHQD----QAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSL 276
P F+ A ++ + DD++Y+FF E + + + + R+A++C+GDQGG +L
Sbjct: 208 EPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTL 267
Query: 277 SVSKWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFS---NPWNYSA 333
KW +FLKA L+CS + FN L+DVF+L P + Y +F+ N SA
Sbjct: 268 Q-KKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPG--LKVPVFYALFTPQLNNVGLSA 324
Query: 334 VCVYSLGDIDKVFRTSSLK-------------GYHSSLPNPRPGKCLPDQQ--------- 371
VC Y+L ++VF Y+ +P PRPG C+ +
Sbjct: 325 VCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSL 384
Query: 372 PIPTETFQVADRHPEVAQRVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTT 431
+P +T Q HP + V P+ + L +Y ++ V R QA G + V++++T
Sbjct: 385 NLPDKTLQFVKDHPLMDDSVTPIDN-RPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVST 443
Query: 432 DRGTIHKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAER--RKLYVSSQWEVSQVP 489
DRG +HK + H I E Q F+ +QT+ L +++ R +Y S V Q P
Sbjct: 444 DRGALHKAISLEHAVHI----IEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAP 499
Query: 490 LDLCEVYGGGCHGCLMSRDPYCGWD--QGRCISIYSSE---RSVLQSINPAEPHKECPNP 544
L C + G C C+++RDPYC W C++++ +E R ++Q + + CP+
Sbjct: 500 LAFCGKH-GTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEM--SGDASVCPD- 555
Query: 545 KPDKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPGH---QSPNCILFIE 601
K ++ L C +S A W+ + V ++ P + N ++F
Sbjct: 556 -KSKGSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNGVLKAESPKYGLMGRKNLLIF-- 612
Query: 602 NLTAQQYGHYFCEAQE 617
NL+ G Y C ++E
Sbjct: 613 NLSEGDSGVYQCLSEE 628
>gi|41406086 semaphorin 3D [Homo sapiens]
Length = 777
Score = 190 bits (482), Expect = 4e-48
Identities = 152/551 (27%), Positives = 253/551 (45%), Gaps = 60/551 (10%)
Query: 125 DCENYITLLERRSEG-LLACGTNARHPSCWNLVNGTVVP----------LGEMRGYAPFS 173
+C N+I +L+ ++ + CGT A HP C + G L R PF
Sbjct: 127 ECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFD 186
Query: 174 PDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELY-------TSDTVMQNPQFIK 226
P + + + +YS ++ GK F R G + + + + +FI
Sbjct: 187 PQQPFASVMTDEYLYSGTAS-DFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIG 245
Query: 227 ATIVHQD-QAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFL 285
+ DDKIY+FFRE + + + +SRV ++C+ D GG+ SL ++KW TFL
Sbjct: 246 TFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSL-INKWTTFL 304
Query: 286 KAMLVCS---DAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVF---SNPWNYSAVCVYSL 339
KA L+CS + F+ LQD++LLP + R+ VYGVF S+ + SAVCVYS+
Sbjct: 305 KARLICSIPGSDGADTYFDELQDIYLLP--TRDERNPVVYGVFTTTSSIFKGSAVCVYSM 362
Query: 340 GDIDKVFRTSSLKG---------YHSSLPNPRPGKC--------LPDQQPIPTETFQVAD 382
DI VF Y +P PRPG C + + P +
Sbjct: 363 ADIRAVFNGPYAHKESADHRWVQYDGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVISFIK 422
Query: 383 RHPEVAQRVEPMGPLKT-PLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVE 441
RH + + V P+ T + Y ++ V + A G+ + V++L TD GT+ KVV
Sbjct: 423 RHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQ-YDVMFLGTDIGTVLKVVS 481
Query: 442 PGEQEHSFAFNIME-IQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGC 500
+++ + ++E +Q F+ ++ I M L ++++LY+ S+ + Q+ L C+ YG C
Sbjct: 482 ISKEKWNMEEVVLEELQIFKHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKAC 541
Query: 501 HGCLMSRDPYCGWDQGRC--ISIYSSERSVLQSINPAEPHKEC----PNPKPDKAPLQKV 554
C ++RDPYC WD C + S R+ Q + +P +C + + A + +
Sbjct: 542 ADCCLARDPYCAWDGNACSRYAPTSKRRARRQDVKYGDPITQCWDIEDSISHETADEKVI 601
Query: 555 SLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCI-----LFIENLTAQQYG 609
+ +L C +S+ AT W + + ++ E I L I +L + G
Sbjct: 602 FGIEFNSTFLECIPKSQQATIKWYIQRSGDEHREELKPDERIIKTEYGLLIRSLQKKDSG 661
Query: 610 HYFCEAQEGSY 620
Y+C+AQE ++
Sbjct: 662 MYYCKAQEHTF 672
>gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]
Length = 738
Score = 190 bits (482), Expect = 4e-48
Identities = 155/546 (28%), Positives = 243/546 (44%), Gaps = 77/546 (14%)
Query: 66 RVDFGQTEPHTVLFHEPG------------SSSVWVGGRGKVYLFDFPE--GKNASVRTV 111
R+ + E H V FHEP ++++G R V+ + K V
Sbjct: 29 RITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWK 88
Query: 112 NIGSTKGSCLDK-----RDCENYITLLERRSE-GLLACGTNARHPSCWNLVNGTVVPLGE 165
K C +K +C NYI +L+ S L CGTNA P+C +L + LG+
Sbjct: 89 VSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGK 148
Query: 166 M---RGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTV--MQ 220
+G PF P + + E+YS + G P R S L T + +
Sbjct: 149 NEDGKGRCPFDPAHSYTSVMVDGELYSGT-SYNFLGSEPIISRNSSHSPLRTEYAIPWLN 207
Query: 221 NPQFIKATIVHQD----QAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSL 276
P F+ A ++ + DD++Y+FF E + + + + R+A++C+GDQGG +L
Sbjct: 208 EPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTL 267
Query: 277 SVSKWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFS---NPWNYSA 333
KW +FLKA L+CS + FN L+DVF+L P + Y +F+ N SA
Sbjct: 268 Q-KKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPG--LKVPVFYALFTPQLNNVGLSA 324
Query: 334 VCVYSLGDIDKVFRTSSLK-------------GYHSSLPNPRPGKCLPDQQ--------- 371
VC Y+L ++VF Y+ +P PRPG C+ +
Sbjct: 325 VCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSL 384
Query: 372 PIPTETFQVADRHPEVAQRVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTT 431
+P +T Q HP + V P+ + L +Y ++ V R QA G + V++++T
Sbjct: 385 NLPDKTLQFVKDHPLMDDSVTPIDN-RPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVST 443
Query: 432 DRGTIHKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAER--RKLYVSSQWEVSQVP 489
DRG +HK + H I E Q F+ +QT+ L +++ R +Y S V Q P
Sbjct: 444 DRGALHKAISLEHAVHI----IEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAP 499
Query: 490 LDLCEVYGGGCHGCLMSRDPYCGWD--QGRCISIYSSE---RSVLQ------SINPAEPH 538
L C + G C C+++RDPYC W C++++ +E R ++Q S+ PA
Sbjct: 500 LAFCGKH-GTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDASVCPASSP 558
Query: 539 KECPNP 544
K P P
Sbjct: 559 KPLPPP 564
>gi|9910362 semaphorin sem2 [Homo sapiens]
Length = 782
Score = 181 bits (460), Expect = 1e-45
Identities = 158/545 (28%), Positives = 240/545 (44%), Gaps = 74/545 (13%)
Query: 125 DCENYITLLERRSEG-LLACGTNARHPSCWNLVNGTVVPLGEM------------RGYAP 171
+C N++ +L+ + LLACGT A P+C + TV GE RG P
Sbjct: 115 ECANFVRVLQPHNRTHLLACGTGAFQPTCALI---TVGHRGEHVLHLEPGSVESGRGRCP 171
Query: 172 FSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDT---VMQNPQFIKAT 228
P F E+Y+ + ++ G+ R G SD+ ++ +P+F+ A
Sbjct: 172 HEPSRPFASTFIDGELYTGLTA-DFLGREAMIFRSGGPRPALRSDSDQSLLHDPRFVMAA 230
Query: 229 IVHQDQAYD-DKIYYFFREDNPDKNPEAPLN---VSRVAQLCRGDQGGESSLSVSKWNTF 284
+ ++ D DK+Y+FF E P +P+ N VSRV ++C D GG+ L V+KW+TF
Sbjct: 231 RIPENSDQDNDKVYFFFSETVP--SPDGGSNHVTVSRVGRVCVNDAGGQRVL-VNKWSTF 287
Query: 285 LKAMLVCS---DAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNP---WNYSAVCVYS 338
LKA LVCS +F++L+DVFLL +G + VY +FS + AVCVY
Sbjct: 288 LKARLVCSVPGPGGAETHFDQLEDVFLLWPKAG--KSLEVYALFSTVSAVFQGFAVCVYH 345
Query: 339 LGDIDKVFR---------TSSLKGYHSSLPNPRPGKC-----------LPDQQPIPTETF 378
+ DI +VF Y +P PRPG C + P E
Sbjct: 346 MADIWEVFNGPFAHRDGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVL 405
Query: 379 QVADRHPEVAQRVEPM-GPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIH 437
Q A HP + V P G H ++ V R++A G T+ V++L TD G++
Sbjct: 406 QFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDG-TYDVIFLGTDSGSVL 464
Query: 438 KVV--EPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEV 495
KV+ + G + E+Q F+ I M + +R+ LYV S+ V+Q+ L CE
Sbjct: 465 KVIALQAGGSAEPEEVVLEELQVFKVPTPITEMEISVKRQMLYVGSRLGVAQLRLHQCET 524
Query: 496 YGGGCHGCLMSRDPYCGWDQGRCISIYSS---ERSVLQSINPAEPHKECPNPKPDKAPLQ 552
YG C C ++RDPYC WD C S R Q I P +C ++ +
Sbjct: 525 YGTACAECCLARDPYCAWDGASCTHYRPSLGKRRFRRQDIRHGNPALQCLGQSQEEEAVG 584
Query: 553 KVSL-----APNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFIENLTAQQ 607
V+ ++ +L C +S A W + PG + P+ + E + +
Sbjct: 585 LVAATMVYGTEHNSTFLECLPKSPQAAVRWLLQ-------RPGDEGPDQVKTDERVLHTE 637
Query: 608 YGHYF 612
G F
Sbjct: 638 RGLLF 642
>gi|19923279 semaphorin W [Homo sapiens]
Length = 770
Score = 180 bits (456), Expect = 4e-45
Identities = 192/704 (27%), Positives = 296/704 (42%), Gaps = 78/704 (11%)
Query: 12 SAPRARVPGPPARLGLPLRLRLLLLLWAAAASAQGHL-RSGPRI-FAVWKGHVGQDRVDF 69
SA R R PGP P L LL +L + G + RS PR + + R
Sbjct: 4 SAARPR-PGPGQPTASPFPLLLLAVL---SGPVSGRVPRSVPRTSLPISEADSCLTRFAV 59
Query: 70 GQTEPHTVLFHEPGSSSVWVGGRGKVYLFDFPEGKNASVRT--VNIGSTKGSCLDKR--- 124
T ++VL +P S +++VG R ++ P R + + + +C K
Sbjct: 60 PHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKE 119
Query: 125 -DCENYITLLE-RRSEGLLACGTNARHPSCWNLVNGT---VVPLGEMRGYAPFSPDENSL 179
+C N++ +L + LL CGT A P C + V L RG PF P + S
Sbjct: 120 DECHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSA 179
Query: 180 VLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYT-SDTV---MQNPQFIKATIVHQ--- 232
+ G +Y+ K Y G P R G +E + +DT+ + P F+ A +
Sbjct: 180 AVMAGGVLYAATVKN-YLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEW 238
Query: 233 -DQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVC 291
D+ DD+IY+FF E + + + V RVA++C GD GG +L +W TFLKA L+C
Sbjct: 239 GDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQ-QRWTTFLKADLLC 297
Query: 292 SDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPW---NYSAVCVYSLGDIDKVFR- 347
+ + LQDV +L G YG+FS+ W SAVC + DI V
Sbjct: 298 PGPEHGRASSVLQDVAVLRPELGAGTPI-FYGIFSSQWEGATISAVCAFRPQDIRTVLNG 356
Query: 348 ---------TSSLKGYHSSLPNPRPGKCLPDQQ---------PIPTETFQVADRHPEVAQ 389
L + +P PRPG+C+ + +P HP + +
Sbjct: 357 PFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDR 416
Query: 390 RVEPMG--PLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGEQEH 447
V P PL L + Y +V HR+ + G+ + VLYL T+ G +H+ V G Q
Sbjct: 417 PVFPADGHPL---LVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQ-- 471
Query: 448 SFAFNIME-IQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMS 506
+++E + F ++ M L L V S+ EV+QV C C C+++
Sbjct: 472 ---LSVLEDLALFPEPQPVENMKL--YHSWLLVGSRTEVTQVNTTNCGRL-QSCSECILA 525
Query: 507 RDPYCGWD--QGRCISIYSSERSVLQSINPAEPHKECPNPKPDKAPLQKVSLAPNSRYYL 564
+DP C W C++ R ++Q I A+ CP ++ + +V +A + L
Sbjct: 526 QDPVCAWSFRLDECVAHAGEHRGLVQDIESADVSSLCPKEPGERPVVFEVPVATAAHVVL 585
Query: 565 SCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFIENLTAQQYGHYFCEAQEGSYFREA 624
C S A+ W H+ + + P + +T G Y CE QEG
Sbjct: 586 PCSPSSAWASCVW-HQPSGVTALTPRRDGLEVV-----VTPGAMGAYACECQEGGAAHVV 639
Query: 625 QHWQLL---PEDGIMAEHLLGHACALAASLWLGVL-PTLTLGLL 664
+ L+ D H +G A A +LG+L +LTL L+
Sbjct: 640 AAYSLVWGSQRDAPSRAHTVG---AGLAGFFLGILAASLTLILI 680
>gi|28872814 semaphorin 4G [Homo sapiens]
Length = 843
Score = 173 bits (439), Expect = 4e-43
Identities = 162/606 (26%), Positives = 253/606 (41%), Gaps = 73/606 (12%)
Query: 70 GQTEPHTVLFHEPGSSSVWVGGRGKVYLF---DFPEGKNASVRTVNIGSTKGSCLDK--- 123
GQ + ++ L E S+ + VG RG ++ D +G + + + C K
Sbjct: 51 GQAQNYSTLLLEEASARLLVGARGALFSLSANDIGDGAHKEIHWEASPEMQSKCHQKGKN 110
Query: 124 --RDCENYITLLER-RSEGLLACGTNARHPSCWNL-VNGTVVPLG--EMRGYAPFSPDEN 177
+C N++ L+R S L ACGT+A P C + +P E + P+ P
Sbjct: 111 NQTECFNHVRFLQRLNSTHLYACGTHAFQPLCAAIDAEAFTLPTSFEEGKEKCPYDPARG 170
Query: 178 SLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQ---NPQFIKATIVHQDQ 234
L +Y+ R + + IP RR R L T +T M + +F+ + +V + +
Sbjct: 171 FTGLIIDGGLYTATRYEFRS--IPDIRRSRHPHSLRTEETPMHWLNDAEFVFSVLVRESK 228
Query: 235 AY----DDKIYYFFREDNPDKNP------EAPLNVSRVAQLCRGDQGGESSLSVSKWNTF 284
A DDK+YYFF E ++ + V+RVA++C+GD GG+ L KW +F
Sbjct: 229 ASAVGDDDKVYYFFTERATEEGSGSFTQSRSSHRVARVARVCKGDLGGKKILQ-KKWTSF 287
Query: 285 LKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVF--SNPWNY---SAVCVYSL 339
LKA L+C + L+ V L + T Y F S W SA+C Y L
Sbjct: 288 LKARLICHIPL----YETLRGVCSLDAETSS--RTHFYAAFTLSTQWKTLEASAICRYDL 341
Query: 340 GDIDKVFRTSSLK---------GYHSSLPNPRPGKCLPDQ---------QPIPTETFQVA 381
+I VF ++ Y +P PRPG C+ D Q +P+
Sbjct: 342 AEIQAVFAGPYMEYQDGSRRWGRYEGGVPEPRPGSCITDSLRSQGYNSSQDLPSLVLDFV 401
Query: 382 DRHPEVAQRVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVE 441
HP +A+ V P + L Y + + G T+ +L+L T G IHK V
Sbjct: 402 KLHPLMARPVVPTRG-RPLLLKRNIRYTHLTGTPVTTPAGPTYDLLFLGTADGWIHKAVV 460
Query: 442 PGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCH 501
G H I E Q FR + +++ + + + LYV + V Q+PL C Y C+
Sbjct: 461 LGSGMHI----IEETQVFRESQSVENLVISLLQHSLYVGAPSGVIQLPLSSCSRYRS-CY 515
Query: 502 GCLMSRDPYCGWDQG--RCISI-------YSSERSVLQSINPAEPHKECPNPKPDKAPLQ 552
C+++RDPYCGWD G C + S +++Q I E PL+
Sbjct: 516 DCILARDPYCGWDPGTHACAAATTIANRSQGSRTALIQDIERGNRGCESSRDTGPPPPLK 575
Query: 553 KVSLAPNSRYYLSCPMESRHATYSWRHKENVEQS-CEPGHQSPNCILFIENLTAQQYGHY 611
S+ L C S A W ++ S + G++ L + + + G+Y
Sbjct: 576 TRSVLRGDDVLLPCDQPSNLARALWLLNGSMGLSDGQGGYRVGVDGLLVTDAQPEHSGNY 635
Query: 612 FCEAQE 617
C A+E
Sbjct: 636 GCYAEE 641
>gi|157388902 semaphorin 4C [Homo sapiens]
Length = 833
Score = 165 bits (417), Expect = 1e-40
Identities = 149/550 (27%), Positives = 238/550 (43%), Gaps = 63/550 (11%)
Query: 117 KGSCLDK-----RDCENYITLLER-RSEGLLACGTNARHPSCWNLVNGTVVPL--GEM-- 166
K C+ K +C N+I L+ + L CGT A P C VN L GE
Sbjct: 96 KTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKC-TYVNMLTFTLEHGEFED 154
Query: 167 -RGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTV---MQNP 222
+G P+ P + L E+YS + G P R G ++ + + P
Sbjct: 155 GKGKCPYDPAKGHAGLLVDGELYSATLNN-FLGTEPIILRNMGPHHSMKTEYLAFWLNEP 213
Query: 223 QFIKATIVHQDQAY----DDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSV 278
F+ + V + DDK+Y+FFRE + + A V+RVA++C+GD GG +L
Sbjct: 214 HFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGGARTLQ- 272
Query: 279 SKWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWN---YSAVC 335
KW TFLKA L CS FN+LQ + L D S W +T +GVF W SA+C
Sbjct: 273 RKWTTFLKARLACSAPNWQLYFNQLQAMHTLQDTS--WHNTTFFGVFQAQWGDMYLSAIC 330
Query: 336 VYSLGDIDKVFRTSSLKGYHSS----------LPNPRPGKCL---------PDQQPIPTE 376
Y L +I +VF K YH +P+PRPG C+ +P
Sbjct: 331 EYQLEEIQRVFE-GPYKEYHEEAQKWDRYTDPVPSPRPGSCINNWHRRHGYTSSLELPDN 389
Query: 377 TFQVADRHPEVAQRVEPMGPLKTPLFHSK-YHYQKVAVHRMQASHGETFHVLYLTTDRGT 435
+HP + ++V P PL K ++ + R+ G T+ VL++ T G
Sbjct: 390 ILNFVKKHPLMEEQVGPR--WSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFIGTGDGW 447
Query: 436 IHKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEV 495
+ K V G H I E+Q F + ++++ L ++ L+ S+ ++ Q+P+ C
Sbjct: 448 LLKAVSLGPWVHL----IEELQLFDQ-EPMRSLVLSQSKKLLFAGSRSQLVQLPVADCMK 502
Query: 496 YGGGCHGCLMSRDPYCGW--DQGRCISIYSSERSVL-QSINPAEPHKEC--PNPKPDKAP 550
Y C C+++RDPYC W + RC+++ S+L Q + ++ C K +
Sbjct: 503 Y-RSCADCVLARDPYCAWSVNTSRCVAVGGHSGSLLIQHVMTSDTSGICNLRGSKKVRPT 561
Query: 551 LQKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPG---HQSPNCILFIENLTAQQ 607
+ +++ + L C + S A W + +PG + + L + +
Sbjct: 562 PKNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQPGSFLYDARLQALVVMAAQPRH 621
Query: 608 YGHYFCEAQE 617
G Y C ++E
Sbjct: 622 AGAYHCFSEE 631
>gi|21361914 semaphorin B [Homo sapiens]
Length = 761
Score = 164 bits (416), Expect = 2e-40
Identities = 201/722 (27%), Positives = 304/722 (42%), Gaps = 114/722 (15%)
Query: 21 PPARLGLPL--RLRLLLLLWAAAASAQGHLRSGPRIFAVWKGHVGQDR--VDF----GQT 72
P + LGL L L+LLL A QG + PR+ + + G +R + F G
Sbjct: 10 PWSLLGLFLFQLLQLLLPTTTAGGGGQGPM---PRV----RYYAGDERRALSFFHQKGLQ 62
Query: 73 EPHTVLFHEPGSSSVWVGGRGKVYLFDF-----PEGKNASVRTVNIGSTKGSCLDKR--- 124
+ T+L G++ ++VG R + D P KN + K C K+
Sbjct: 63 DFDTLLLSGDGNT-LYVGAREAILALDIQDPGVPRLKNMIPWPAS-DRKKSECAFKKKSN 120
Query: 125 --DCENYI-TLLERRSEGLLACGTNARHPSCW--NLVNGTVVPLGEMR-----GYAPFSP 174
C N+I L+ L CGT A P+C L + ++P+ E + G +PF P
Sbjct: 121 ETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQSPFDP 180
Query: 175 -DENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQD 233
+++ VL +G T+ + G P R G S V++ F++ +H D
Sbjct: 181 AHKHTAVLVDGMLYSGTMNN--FLGSEPILMRTLG------SQPVLKTDNFLRW--LHHD 230
Query: 234 QAY------DDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKA 287
++ +Y+FF E + + L+ SRVA++C+ D GGE L KW TFLKA
Sbjct: 231 ASFVAAIPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQ-KKWTTFLKA 289
Query: 288 MLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY-----SAVCVYSLGDI 342
L+C+ FN ++ LLP S +Y VF++ W SAVC +SL DI
Sbjct: 290 QLLCTQPG-QLPFNVIRHAVLLPADSP--TAPHIYAVFTSQWQVGGTRSSAVCAFSLLDI 346
Query: 343 DKVFR---------TSSLKGYHSSLPNPRPGKCLPDQQPIPTETFQVADRHPEVAQRVEP 393
++VF+ TS Y NPRPG C P + H + ++V
Sbjct: 347 ERVFKGKYKELNKETSRWTTYRGPETNPRPGSC--SVGPSSDKALTFMKDHFLMDEQV-- 402
Query: 394 MGPLKTPLF-HSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGEQEHSFAFN 452
+ TPL S Y ++AV Q G + V+YL T G++HK V G+ S A
Sbjct: 403 ---VGTPLLVKSGVEYTRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGD---SSAHL 456
Query: 453 IMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCG 512
+ EIQ F ++ + L + ++V V +VP C VY C C+++RDP+C
Sbjct: 457 VEEIQLFPDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVY-ESCVDCVLARDPHCA 515
Query: 513 WD---QGRCISIYSSERSVLQSINPAEPHKECPNP------KPDKAP--LQKVSLAPNSR 561
WD + C+ + S Q + P C + +P P +++V PNS
Sbjct: 516 WDPESRTCCLLSAPNLNSWKQDMERGNPEWACASGPMSRSLRPQSRPQIIKEVLAVPNSI 575
Query: 562 YYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFIENLTAQQYGHYFCEAQEG--- 618
L CP S A+Y W H + + +L +++ G Y C A E
Sbjct: 576 LELPCPHLSALASYYWSHGPAAVPEASSTVYNGSLLLIVQDGVG---GLYQCWATENGFS 632
Query: 619 ----SYFREAQHWQLL--PE-DGIMAEHLL--------GHACALAASLWLGVLPTLTLGL 663
SY+ ++Q L PE GI EH+ G A A S W + L
Sbjct: 633 YPVISYWVDSQDQTLALDPELAGIPREHVKVPLTRVSGGAALAAQQSYWPHFVTVTVLFA 692
Query: 664 LV 665
LV
Sbjct: 693 LV 694
>gi|11991660 sema domain, transmembrane domain (TM), and cytoplasmic
domain, (semaphorin) 6A [Homo sapiens]
Length = 1030
Score = 147 bits (372), Expect = 2e-35
Identities = 141/495 (28%), Positives = 210/495 (42%), Gaps = 61/495 (12%)
Query: 84 SSSVWVGGRGKVYLFDFPEGKNASV----------RTVNIGSTKGSCLDKRDCENYI-TL 132
+ ++++ R +Y D + R ++ + + K +C N+I L
Sbjct: 65 NGTLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVL 124
Query: 133 LERRSEGLLACGTNARHPSCWNLVNGTVVPLG-EMRGYA--PFSPDENSLVLFEGDEVYS 189
L++ + L CGTNA +PSC N T+ P G E G A P+ ++ LF ++YS
Sbjct: 125 LKKNDDALFVCGTNAFNPSCRNYKMDTLEPFGDEFSGMARCPYDAKHANVALFADGKLYS 184
Query: 190 TIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDDKIYYFFREDNP 249
+R + GES T TV + +++K Q Y D IY+FFRE
Sbjct: 185 ATVTDFLAIDAVIYRSL-GESP--TLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAV 241
Query: 250 DKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCS-DAATNKNFNRLQDVFL 308
+ N + RVAQ+C+ D GG + +W +FLKA L CS ++ FN LQ V
Sbjct: 242 EYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTD 301
Query: 309 LPDPSGQWRDTRVYGVFSNPWNY---SAVCVYSLGDIDKVF--RTSSLKGYHSS------ 357
+ +G RD V FS P+N SAVC Y + DI VF R K S+
Sbjct: 302 VIRING--RDV-VLATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTWTPVPD 358
Query: 358 --LPNPRPGKC--------LPDQQPIPTETFQVADRHPEVAQRVEPMGPLKTPLF---HS 404
+P PRPG C P +T HP + + V + P F
Sbjct: 359 ERVPKPRPGCCAGSSSLERYATSNEFPDDTLNFIKTHPLMDEAVPSI--FNRPWFLRTMV 416
Query: 405 KYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHK----VVEPGEQEHSFAFNIMEIQPFR 460
+Y K+AV + + V++L +++G I K + G S M +
Sbjct: 417 RYRLTKIAVDTAAGPY-QNHTVVFLGSEKGIILKFLARIGNSGFLNDSLFLEEMSVYNSE 475
Query: 461 RAA-------AIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGW 513
+ + I M LD LYV+ V +VPL CE +G C+ SRDPYCGW
Sbjct: 476 KCSYDGVEDKRIMGMQLDRASSSLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDPYCGW 535
Query: 514 --DQGRCISIYSSER 526
+ G C + + R
Sbjct: 536 IKEGGACSHLSPNSR 550
>gi|147904700 semaphorin 5A [Homo sapiens]
Length = 1074
Score = 139 bits (351), Expect = 6e-33
Identities = 148/493 (30%), Positives = 222/493 (45%), Gaps = 58/493 (11%)
Query: 64 QDRVDFGQTEPHTVLFHEPGSSSVWVGGRGKVYLFDFPEGKNASVRTVNIG---STKGSC 120
++ VDF Q L +PG + VG R YLF + ++ V +TK +C
Sbjct: 53 KNAVDFSQ------LTFDPGQKELVVGARN--YLFRLQLEDLSLIQAVEWECDEATKKAC 104
Query: 121 LDK----RDCENYITLLERRSEGLLACGTNARHPSCWN--LVNGTVVPLGEMRGYA--PF 172
K +C+NYI +L + L CGTNA P C N L N T + ++ G A P+
Sbjct: 105 YSKGKSKEECQNYIRVLLVGGDRLFTCGTNAFTPVCTNRSLSNLTEIH-DQISGMARCPY 163
Query: 173 SPDENSLVLF-EGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVH 231
SP NS L G E+Y+ ++ G+ P R G L T N +++
Sbjct: 164 SPQHNSTALLTAGGELYAA-TAMDFPGRDPAIYRSLG--ILPPLRTAQYNSKWLNEPNFV 220
Query: 232 QDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVC 291
+ Y+FFRE N ++ SR A++C+ D GG L W TF+KA L C
Sbjct: 221 SSYDIGNFTYFFFRE-NAVEHDCGKTVFSRAARVCKNDIGGRFLLE-DTWTTFMKARLNC 278
Query: 292 S-DAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWN---YSAVCVYSLGDIDKVFR 347
S +N LQ F LP+ +YG+F+ N SAVCV++L I + F
Sbjct: 279 SRPGEVPFYYNELQSTFFLPELD------LIYGIFTTNVNSIAASAVCVFNLSAIAQAF- 331
Query: 348 TSSLKGYHSS------LPNPRPG-KCLPDQQPIPTETFQVADRHPEVAQRV----EPMGP 396
+ K +S PNP P +C Q + + +R+ + AQ+ E + P
Sbjct: 332 SGPFKYQENSRSAWLPYPNPNPHFQCGTVDQGL---YVNLTERNLQDAQKFILMHEVVQP 388
Query: 397 LKT-PLF-HSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEP-GEQEHSFAFNI 453
+ T P F + VAV +Q H++YL TD GTI KV P + S
Sbjct: 389 VTTVPSFMEDNSRFSHVAVDVVQGREA-LVHIIYLATDYGTIKKVRVPLNQTSSSCLLEE 447
Query: 454 MEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGW 513
+E+ P RR I+++ + + L+V + V ++PL C+ Y C+ ++DPYCGW
Sbjct: 448 IELFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRTR-STCIGAQDPYCGW 506
Query: 514 D--QGRCISIYSS 524
D +C S+ S
Sbjct: 507 DVVMKKCTSLEES 519
>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
Length = 1151
Score = 137 bits (345), Expect = 3e-32
Identities = 152/575 (26%), Positives = 240/575 (41%), Gaps = 71/575 (12%)
Query: 5 PPGRAAPSAPRARVPGPPARLGLPLRLRLLLLLWAAAASAQGHLRSGPRIFAVWKGHVGQ 64
PPG P + GP A L L LL+ +++ S ++ A+ K
Sbjct: 48 PPGARTAEGPIMVLAGPLAVSLLLPSLTLLVSHLSSSQDVSSEPSSEQQLCALSK----H 103
Query: 65 DRVDFGQTEPHTVLFHEPGS------------SSVWVGGRGKVYLFDFPEGKNASVRTVN 112
V F +P F PG+ + + VG R YLF + ++
Sbjct: 104 PTVAFEDLQPWVSNFTYPGARDFSQLALDPSGNQLIVGARN--YLFRLSLANVSLLQATE 161
Query: 113 IGS---TKGSCLDK----RDCENYITLLERRSEGLLACGTNARHPSCWNLVNGTVV-PLG 164
S T+ SC K +C+NY+ +L + CGTNA P C + G + +
Sbjct: 162 WASSEDTRRSCQSKGKTEEECQNYVRVLIVAGRKVFMCGTNAFSPMCTSRQVGNLSRTIE 221
Query: 165 EMRGYA--PFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGE-----SELYTSDT 217
++ G A P+ P NS + +++G+ P R G + Y S
Sbjct: 222 KINGVARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKW 281
Query: 218 VMQNPQFIKATIVHQDQAYDDKIY-YFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSL 276
+ P F+ A YD ++ YFF +N ++ SRVA++C+ D GG L
Sbjct: 282 -LNEPNFVAA--------YDIGLFAYFFLRENAVEHDCGRTVYSRVARVCKNDVGGRFLL 332
Query: 277 SVSKWNTFLKAMLVCS-DAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY---S 332
W TF+KA L CS +N LQ F LP+ +YGVF+ N S
Sbjct: 333 E-DTWTTFMKARLNCSRPGEVPFYYNELQSAFHLPEQD------LIYGVFTTNVNSIAAS 385
Query: 333 AVCVYSLGDIDKVFR-----TSSLKGYHSSLPNPRPG-KC--LPDQQP---IPTETFQVA 381
AVC ++L I + F + + + NP P +C LP+ P + + Q A
Sbjct: 386 AVCAFNLSAISQAFNGPFRYQENPRAAWLPIANPIPNFQCGTLPETGPNENLTERSLQDA 445
Query: 382 DRHPEVAQRVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVE 441
R +++ V+P+ P + + + + V +QA +HVLY+ T+ GTI K +
Sbjct: 446 QRLFLMSEAVQPVTP-EPCVTQDSVRFSHLVVDLVQAKD-TLYHVLYIGTESGTILKALS 503
Query: 442 PGEQE-HSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGC 500
+ H + + P R ++++ + R L+V + V +VPL+ C Y
Sbjct: 504 TASRSLHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRSQ- 562
Query: 501 HGCLMSRDPYCGWD--QGRCISIYSSERSVLQSIN 533
CL +RDPYCGWD Q RC ++ S L + N
Sbjct: 563 GACLGARDPYCGWDGKQQRCSTLEDSSNMSLWTQN 597
>gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]
Length = 1011
Score = 134 bits (337), Expect = 3e-31
Identities = 125/438 (28%), Positives = 192/438 (43%), Gaps = 53/438 (12%)
Query: 123 KRDCENYITL-LERRSEGLLACGTNARHPSCWNLVNGTVVPLGE-MRGYA--PFSPDENS 178
K +C N+I + + R E + CGTNA +P C T+ GE + G A PF + +
Sbjct: 115 KDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTN 174
Query: 179 LVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDD 238
+ LF ++YS +R + S L T + + ++IK Y +
Sbjct: 175 VALFADGKLYSATVADFLASDAVIYRSMGDGSALRT---IKYDSKWIKEPHFLHAIEYGN 231
Query: 239 KIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATN- 297
+Y+FFRE + N SRVA++C+ D GG + W +FLKA L CS +
Sbjct: 232 YVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSF 291
Query: 298 KNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY---SAVCVYSLGDIDKVF--RTSSLK 352
F+ LQ + + +G V GVF+ N SAVC +S+ DI+KVF R K
Sbjct: 292 FYFDVLQSITDIIQING---IPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQK 348
Query: 353 GYHS--------SLPNPRPGKC--------LPDQQPIPTETFQVADRHPEVAQRVEPMGP 396
S +P PRPG C P ET HP + V P+
Sbjct: 349 TPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIA- 407
Query: 397 LKTPLF-HSKYHYQKVAVH-RMQASHGETFHVLYLTTDRGTIHKVVEPGEQEHSFAFN-- 452
P F ++ Y+ A+ A + + V+++ ++ G + KV+ + F+ N
Sbjct: 408 -DEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVL---AKTSPFSLNDS 463
Query: 453 --IMEIQPFRRAAA---------IQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCH 501
+ EI+ + A + ++ LD + LYV+ + ++PL CE YG
Sbjct: 464 VLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKK 523
Query: 502 GCLMSRDPYCGW-DQGRC 518
C+ SRDPYCGW QG C
Sbjct: 524 SCIASRDPYCGWLSQGSC 541
>gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens]
Length = 597
Score = 134 bits (337), Expect = 3e-31
Identities = 125/438 (28%), Positives = 192/438 (43%), Gaps = 53/438 (12%)
Query: 123 KRDCENYITL-LERRSEGLLACGTNARHPSCWNLVNGTVVPLGE-MRGYA--PFSPDENS 178
K +C N+I + + R E + CGTNA +P C T+ GE + G A PF + +
Sbjct: 115 KDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTN 174
Query: 179 LVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDD 238
+ LF ++YS +R + S L T + + ++IK Y +
Sbjct: 175 VALFADGKLYSATVADFLASDAVIYRSMGDGSALRT---IKYDSKWIKEPHFLHAIEYGN 231
Query: 239 KIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATN- 297
+Y+FFRE + N SRVA++C+ D GG + W +FLKA L CS +
Sbjct: 232 YVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSF 291
Query: 298 KNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY---SAVCVYSLGDIDKVF--RTSSLK 352
F+ LQ + + +G V GVF+ N SAVC +S+ DI+KVF R K
Sbjct: 292 FYFDVLQSITDIIQING---IPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQK 348
Query: 353 GYHS--------SLPNPRPGKC--------LPDQQPIPTETFQVADRHPEVAQRVEPMGP 396
S +P PRPG C P ET HP + V P+
Sbjct: 349 TPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIA- 407
Query: 397 LKTPLF-HSKYHYQKVAVH-RMQASHGETFHVLYLTTDRGTIHKVVEPGEQEHSFAFN-- 452
P F ++ Y+ A+ A + + V+++ ++ G + KV+ + F+ N
Sbjct: 408 -DEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVL---AKTSPFSLNDS 463
Query: 453 --IMEIQPFRRAAA---------IQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCH 501
+ EI+ + A + ++ LD + LYV+ + ++PL CE YG
Sbjct: 464 VLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKK 523
Query: 502 GCLMSRDPYCGW-DQGRC 518
C+ SRDPYCGW QG C
Sbjct: 524 SCIASRDPYCGWLSQGSC 541
>gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]
Length = 1073
Score = 134 bits (337), Expect = 3e-31
Identities = 125/438 (28%), Positives = 192/438 (43%), Gaps = 53/438 (12%)
Query: 123 KRDCENYITL-LERRSEGLLACGTNARHPSCWNLVNGTVVPLGE-MRGYA--PFSPDENS 178
K +C N+I + + R E + CGTNA +P C T+ GE + G A PF + +
Sbjct: 115 KDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTN 174
Query: 179 LVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDD 238
+ LF ++YS +R + S L T + + ++IK Y +
Sbjct: 175 VALFADGKLYSATVADFLASDAVIYRSMGDGSALRT---IKYDSKWIKEPHFLHAIEYGN 231
Query: 239 KIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATN- 297
+Y+FFRE + N SRVA++C+ D GG + W +FLKA L CS +
Sbjct: 232 YVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSF 291
Query: 298 KNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY---SAVCVYSLGDIDKVF--RTSSLK 352
F+ LQ + + +G V GVF+ N SAVC +S+ DI+KVF R K
Sbjct: 292 FYFDVLQSITDIIQING---IPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQK 348
Query: 353 GYHS--------SLPNPRPGKC--------LPDQQPIPTETFQVADRHPEVAQRVEPMGP 396
S +P PRPG C P ET HP + V P+
Sbjct: 349 TPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIA- 407
Query: 397 LKTPLF-HSKYHYQKVAVH-RMQASHGETFHVLYLTTDRGTIHKVVEPGEQEHSFAFN-- 452
P F ++ Y+ A+ A + + V+++ ++ G + KV+ + F+ N
Sbjct: 408 -DEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVL---AKTSPFSLNDS 463
Query: 453 --IMEIQPFRRAAA---------IQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCH 501
+ EI+ + A + ++ LD + LYV+ + ++PL CE YG
Sbjct: 464 VLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKK 523
Query: 502 GCLMSRDPYCGW-DQGRC 518
C+ SRDPYCGW QG C
Sbjct: 524 SCIASRDPYCGWLSQGSC 541
>gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]
Length = 1017
Score = 134 bits (337), Expect = 3e-31
Identities = 125/438 (28%), Positives = 192/438 (43%), Gaps = 53/438 (12%)
Query: 123 KRDCENYITL-LERRSEGLLACGTNARHPSCWNLVNGTVVPLGE-MRGYA--PFSPDENS 178
K +C N+I + + R E + CGTNA +P C T+ GE + G A PF + +
Sbjct: 115 KDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTN 174
Query: 179 LVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDD 238
+ LF ++YS +R + S L T + + ++IK Y +
Sbjct: 175 VALFADGKLYSATVADFLASDAVIYRSMGDGSALRT---IKYDSKWIKEPHFLHAIEYGN 231
Query: 239 KIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATN- 297
+Y+FFRE + N SRVA++C+ D GG + W +FLKA L CS +
Sbjct: 232 YVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSF 291
Query: 298 KNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY---SAVCVYSLGDIDKVF--RTSSLK 352
F+ LQ + + +G V GVF+ N SAVC +S+ DI+KVF R K
Sbjct: 292 FYFDVLQSITDIIQING---IPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQK 348
Query: 353 GYHS--------SLPNPRPGKC--------LPDQQPIPTETFQVADRHPEVAQRVEPMGP 396
S +P PRPG C P ET HP + V P+
Sbjct: 349 TPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIA- 407
Query: 397 LKTPLF-HSKYHYQKVAVH-RMQASHGETFHVLYLTTDRGTIHKVVEPGEQEHSFAFN-- 452
P F ++ Y+ A+ A + + V+++ ++ G + KV+ + F+ N
Sbjct: 408 -DEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVL---AKTSPFSLNDS 463
Query: 453 --IMEIQPFRRAAA---------IQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCH 501
+ EI+ + A + ++ LD + LYV+ + ++PL CE YG
Sbjct: 464 VLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKK 523
Query: 502 GCLMSRDPYCGW-DQGRC 518
C+ SRDPYCGW QG C
Sbjct: 524 SCIASRDPYCGWLSQGSC 541
>gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]
Length = 998
Score = 134 bits (337), Expect = 3e-31
Identities = 125/438 (28%), Positives = 192/438 (43%), Gaps = 53/438 (12%)
Query: 123 KRDCENYITL-LERRSEGLLACGTNARHPSCWNLVNGTVVPLGE-MRGYA--PFSPDENS 178
K +C N+I + + R E + CGTNA +P C T+ GE + G A PF + +
Sbjct: 115 KDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTN 174
Query: 179 LVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDD 238
+ LF ++YS +R + S L T + + ++IK Y +
Sbjct: 175 VALFADGKLYSATVADFLASDAVIYRSMGDGSALRT---IKYDSKWIKEPHFLHAIEYGN 231
Query: 239 KIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATN- 297
+Y+FFRE + N SRVA++C+ D GG + W +FLKA L CS +
Sbjct: 232 YVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSF 291
Query: 298 KNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY---SAVCVYSLGDIDKVF--RTSSLK 352
F+ LQ + + +G V GVF+ N SAVC +S+ DI+KVF R K
Sbjct: 292 FYFDVLQSITDIIQING---IPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQK 348
Query: 353 GYHS--------SLPNPRPGKC--------LPDQQPIPTETFQVADRHPEVAQRVEPMGP 396
S +P PRPG C P ET HP + V P+
Sbjct: 349 TPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIA- 407
Query: 397 LKTPLF-HSKYHYQKVAVH-RMQASHGETFHVLYLTTDRGTIHKVVEPGEQEHSFAFN-- 452
P F ++ Y+ A+ A + + V+++ ++ G + KV+ + F+ N
Sbjct: 408 -DEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVL---AKTSPFSLNDS 463
Query: 453 --IMEIQPFRRAAA---------IQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCH 501
+ EI+ + A + ++ LD + LYV+ + ++PL CE YG
Sbjct: 464 VLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKK 523
Query: 502 GCLMSRDPYCGW-DQGRC 518
C+ SRDPYCGW QG C
Sbjct: 524 SCIASRDPYCGWLSQGSC 541
>gi|16306552 semaphorin Y [Homo sapiens]
Length = 930
Score = 131 bits (329), Expect = 2e-30
Identities = 122/442 (27%), Positives = 190/442 (42%), Gaps = 52/442 (11%)
Query: 125 DCENYI-TLLERRSEGLLACGTNARHPSCWNLVNGTVVPLGE-MRGYA--PFSPDENSLV 180
+C NYI L+ S+ LLACGTN+ P C + ++ GE + G A PF ++++
Sbjct: 120 ECYNYIRVLVPWDSQTLLACGTNSFSPVCRSYGITSLQQEGEELSGQARCPFDATQSNVA 179
Query: 181 LFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTS---DTVMQNPQFIKATIVHQDQAYD 237
+F +YS +R + + L ++ ++ P F++A +
Sbjct: 180 IFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFVQAL------EHG 233
Query: 238 DKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATN 297
D +Y+FFRE + + + SRVA++C+ D GG W +FLK L CS +
Sbjct: 234 DHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDS 293
Query: 298 K-NFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY---SAVCVYSLGDIDKVFRTS---- 349
F+ LQ L P + ++GVF+ N SAVC + L +I++ F
Sbjct: 294 TFYFDVLQ---ALTGPVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFEGKFKEQ 350
Query: 350 -SLKGY-----HSSLPNPRPGKC--------LPDQQPIPTETFQVADRHPEVAQRVEPMG 395
SL G +P+PRPG C + +P + HP + V P+
Sbjct: 351 RSLDGAWTPVSEDRVPSPRPGSCAGVGGAALFSSSRDLPDDVLTFIKAHPLLDPAVPPVT 410
Query: 396 PLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGEQ----EHSFAF 451
S+ +VAV M H V++L ++ GT+ KV+ PG + E
Sbjct: 411 HQPLLTLTSRALLTQVAVDGMAGPHSN-ITVMFLGSNDGTVLKVLTPGGRSGGPEPILLE 469
Query: 452 NIMEIQPFR--------RAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGC 503
I P R A I + LD E +L+V+ + +PL C +G C
Sbjct: 470 EIDAYSPARCSGKRTAQTARRIIGLELDTEGHRLFVAFSGCIVYLPLSRCARHGACQRSC 529
Query: 504 LMSRDPYCGWDQGR-CISIYSS 524
L S+DPYCGW R C+ I S
Sbjct: 530 LASQDPYCGWHSSRGCVDIRGS 551
>gi|19718780 semaphorin 6B precursor [Homo sapiens]
Length = 888
Score = 123 bits (309), Expect = 5e-28
Identities = 130/473 (27%), Positives = 204/473 (43%), Gaps = 74/473 (15%)
Query: 111 VNIGSTKGSCLDKRDCENYITLLERRSEG-LLACGTNARHPSCWNLVNGTVVPLGE-MRG 168
+N+ KG + +C N++ +L R E L CG+NA +P C N T+ P+G+ + G
Sbjct: 113 INVCRMKGK--QEGECRNFVKVLLLRDESTLFVCGSNAFNPVCANYSIDTLQPVGDNISG 170
Query: 169 YA--PFSPDENSLVLFEGDEVYST-------IRKQEYN--GKIPRFRRIRGESELYTSDT 217
A P+ P ++ LF +++ I Y G P R ++ +S+ +
Sbjct: 171 MARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWF---- 226
Query: 218 VMQNPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLS 277
+ P F+ A + +Y+FFRE + N + VSRVA++C+ D GG +
Sbjct: 227 --KEPYFVHAV------EWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVL 278
Query: 278 VSKWNTFLKAMLVCS-DAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY---SA 333
+W +FLKA L CS ++ FN LQ V + G+ V VFS P N SA
Sbjct: 279 EKQWTSFLKARLNCSVPGDSHFYFNVLQAVTGVVSLGGR---PVVLAVFSTPSNSIPGSA 335
Query: 334 VCVYSLGDIDKVF--RTSSLKGYHS--------SLPNPRPGKC-LPDQQ-----PIPTET 377
VC + L + VF R K S +P PRPG C P Q +P +
Sbjct: 336 VCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPGMQYNASSALPDDI 395
Query: 378 FQVADRHPEVAQRVEPMGP----LKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDR 433
HP + + V +G L+T + H +VAV G V++L ++
Sbjct: 396 LNFVKTHPLMDEAVPSLGHAPWILRTLMRH---QLTRVAVDVGAGPWGNQ-TVVFLGSEA 451
Query: 434 GTIHK-VVEPGEQ---EHSFAFNIMEIQPFR-----------RAAAIQTMSLDAERRKLY 478
GT+ K +V P + + E + +R + ++ LDA L
Sbjct: 452 GTVLKFLVRPNASTSGTSGLSVFLEEFETYRPDRCGRPGGGETGQRLLSLELDAASGGLL 511
Query: 479 VSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGW-DQGRCISIYSSERSVLQ 530
+ V +VP+ C+ Y G C+ S+DPYCGW G CI + R+ +
Sbjct: 512 AAFPRCVVRVPVARCQQYSGCMKNCIGSQDPYCGWAPDGSCIFLSPGTRAAFE 564
>gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens]
Length = 476
Score = 95.9 bits (237), Expect = 1e-19
Identities = 97/346 (28%), Positives = 150/346 (43%), Gaps = 36/346 (10%)
Query: 123 KRDCENYITL-LERRSEGLLACGTNARHPSCWNLVNGTVVPLGE-MRGYA--PFSPDENS 178
K +C N+I + + R E + CGTNA +P C T+ GE + G A PF + +
Sbjct: 115 KDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTN 174
Query: 179 LVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDD 238
+ LF ++YS +R + S L T + + ++IK Y +
Sbjct: 175 VALFADGKLYSATVADFLASDAVIYRSMGDGSALRT---IKYDSKWIKEPHFLHAIEYGN 231
Query: 239 KIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATN- 297
+Y+FFRE + N SRVA++C+ D GG + W +FLKA L CS +
Sbjct: 232 YVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSF 291
Query: 298 KNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY---SAVCVYSLGDIDKVF--RTSSLK 352
F+ LQ + + +G V GVF+ N SAVC +S+ DI+KVF R K
Sbjct: 292 FYFDVLQSITDIIQING---IPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQK 348
Query: 353 GYHS--------SLPNPRPGKC--------LPDQQPIPTETFQVADRHPEVAQRVEPMGP 396
S +P PRPG C P ET HP + V P+
Sbjct: 349 TPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIA- 407
Query: 397 LKTPLF-HSKYHYQKVAVH-RMQASHGETFHVLYLTTDRGTIHKVV 440
P F ++ Y+ A+ A + + V+++ ++ G + KV+
Sbjct: 408 -DEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVL 452
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,497,183
Number of Sequences: 37866
Number of extensions: 1537212
Number of successful extensions: 7005
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 56
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 6718
Number of HSP's gapped (non-prelim): 135
length of query: 666
length of database: 18,247,518
effective HSP length: 109
effective length of query: 557
effective length of database: 14,120,124
effective search space: 7864909068
effective search space used: 7864909068
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.