Search of human proteins with 4504011

Search of human proteins with 4504011

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4504011 glutamate-cysteine ligase regulatory protein [Homo
sapiens]
         (274 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4504011 glutamate-cysteine ligase regulatory protein [Homo sa...   547   e-156
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo...    33   0.27 
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof...    33   0.27 
gi|24497577 aldo-keto reductase family 1, member A1 [Homo sapiens]     31   1.0  
gi|5174391 aldo-keto reductase family 1, member A1 [Homo sapiens]      31   1.0  
gi|149944715 protein phosphatase 1H (PP2C domain containing) [Ho...    31   1.0  
gi|122937516 aldo-keto reductase family 1, member B10-like [Homo...    30   1.7  
gi|223468663 aldo-keto reductase family 1, member B10 [Homo sapi...    30   2.3  
gi|33188443 microfilament and actin filament cross-linker protei...    30   2.3  
gi|33188445 microfilament and actin filament cross-linker protei...    30   2.3  
gi|4502049 aldo-keto reductase family 1, member B1 [Homo sapiens]      30   2.3  
gi|10863929 ribonuclease L [Homo sapiens]                              30   3.0  
gi|5174695 aldo-keto reductase family 1, member D1 [Homo sapiens]      30   3.0  
gi|66346733 chloride intracellular channel 2 [Homo sapiens]            30   3.0  
gi|93277124 aldo-keto reductase family 1, member C-like 2 [Homo ...    29   3.9  
gi|73623035 sperm associated antigen 5 [Homo sapiens]                  29   3.9  
gi|156105697 ring finger and CCCH-type zinc finger domains 2 iso...    29   3.9  
gi|156105699 ring finger and CCCH-type zinc finger domains 2 iso...    29   3.9  
gi|48762700 GTF2I repeat domain containing 2 [Homo sapiens]            28   6.6  
gi|51241788 GTF2I repeat domain containing 2B [Homo sapiens]           28   6.6  

>gi|4504011 glutamate-cysteine ligase regulatory protein [Homo
           sapiens]
          Length = 274

 Score =  547 bits (1409), Expect = e-156
 Identities = 274/274 (100%), Positives = 274/274 (100%)

Query: 1   MGTDSRAAKALLARARTLHLQTGNLLNWGRLRKKCPSTHSEELHDCIQKTLNEWSSQINP 60
           MGTDSRAAKALLARARTLHLQTGNLLNWGRLRKKCPSTHSEELHDCIQKTLNEWSSQINP
Sbjct: 1   MGTDSRAAKALLARARTLHLQTGNLLNWGRLRKKCPSTHSEELHDCIQKTLNEWSSQINP 60

Query: 61  DLVREFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVA 120
           DLVREFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVA
Sbjct: 61  DLVREFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVA 120

Query: 121 QLDSVIIASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQ 180
           QLDSVIIASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQ
Sbjct: 121 QLDSVIIASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQ 180

Query: 181 VKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIQAH 240
           VKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIQAH
Sbjct: 181 VKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIQAH 240

Query: 241 EWVPLWLLRYSVIVKSRGIIKSKGYILQAKRRGS 274
           EWVPLWLLRYSVIVKSRGIIKSKGYILQAKRRGS
Sbjct: 241 EWVPLWLLRYSVIVKSRGIIKSKGYILQAKRRGS 274


>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
            [Homo sapiens]
          Length = 8749

 Score = 33.1 bits (74), Expect = 0.27
 Identities = 24/118 (20%), Positives = 57/118 (48%), Gaps = 23/118 (19%)

Query: 142  HLQPYWEELENLVQSKKIVAIGTSD---LDKTQLEQLYQWAQVKPNSNQVNLASCCVM-- 196
            HL+  W +LE+L++ K  V++   +   + +++ ++L +WA+      Q N+A       
Sbjct: 4249 HLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAE----EQQPNIAEALKQSP 4304

Query: 197  PPDLTAFAKQFDIQLLTHNDPKELLSEASFQEA--------------LQESIPDIQAH 240
            PPD+        + + +  + K++L ++  ++A              +Q+++ D Q+H
Sbjct: 4305 PPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSH 4362


>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
            [Homo sapiens]
          Length = 8797

 Score = 33.1 bits (74), Expect = 0.27
 Identities = 24/118 (20%), Positives = 57/118 (48%), Gaps = 23/118 (19%)

Query: 142  HLQPYWEELENLVQSKKIVAIGTSD---LDKTQLEQLYQWAQVKPNSNQVNLASCCVM-- 196
            HL+  W +LE+L++ K  V++   +   + +++ ++L +WA+      Q N+A       
Sbjct: 4320 HLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAE----EQQPNIAEALKQSP 4375

Query: 197  PPDLTAFAKQFDIQLLTHNDPKELLSEASFQEA--------------LQESIPDIQAH 240
            PPD+        + + +  + K++L ++  ++A              +Q+++ D Q+H
Sbjct: 4376 PPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSH 4433


>gi|24497577 aldo-keto reductase family 1, member A1 [Homo sapiens]
          Length = 325

 Score = 31.2 bits (69), Expect = 1.0
 Identities = 15/47 (31%), Positives = 25/47 (53%)

Query: 142 HLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQV 188
           H +  W+ LE LV    + A+G S+ +  Q++ +   A V+P   QV
Sbjct: 139 HYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQV 185


>gi|5174391 aldo-keto reductase family 1, member A1 [Homo sapiens]
          Length = 325

 Score = 31.2 bits (69), Expect = 1.0
 Identities = 15/47 (31%), Positives = 25/47 (53%)

Query: 142 HLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNSNQV 188
           H +  W+ LE LV    + A+G S+ +  Q++ +   A V+P   QV
Sbjct: 139 HYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQV 185


>gi|149944715 protein phosphatase 1H (PP2C domain containing) [Homo
           sapiens]
          Length = 514

 Score = 31.2 bits (69), Expect = 1.0
 Identities = 15/67 (22%), Positives = 35/67 (52%)

Query: 208 DIQLLTHNDPKELLSEASFQEALQESIPDIQAHEWVPLWLLRYSVIVKSRGIIKSKGYIL 267
           D+ +L  +   ++LS     EA+ + +P+    +     L    +++++RG++K +G+ +
Sbjct: 430 DVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQDLVMRARGVLKDRGWRI 489

Query: 268 QAKRRGS 274
              R GS
Sbjct: 490 SNDRLGS 496


>gi|122937516 aldo-keto reductase family 1, member B10-like [Homo
           sapiens]
          Length = 316

 Score = 30.4 bits (67), Expect = 1.7
 Identities = 16/44 (36%), Positives = 25/44 (56%), Gaps = 2/44 (4%)

Query: 147 WEELENLVQSKKIVAIGTSDLDKTQLEQLYQ--WAQVKPNSNQV 188
           WE +E LV    + A+G S+ +  Q+E+L      + KP +NQV
Sbjct: 142 WEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKPVTNQV 185


>gi|223468663 aldo-keto reductase family 1, member B10 [Homo
           sapiens]
          Length = 316

 Score = 30.0 bits (66), Expect = 2.3
 Identities = 16/44 (36%), Positives = 24/44 (54%), Gaps = 2/44 (4%)

Query: 147 WEELENLVQSKKIVAIGTSDLDKTQLEQLYQ--WAQVKPNSNQV 188
           WE +E LV    + A+G S+    Q+E+L      + KP +NQV
Sbjct: 142 WEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQV 185


>gi|33188443 microfilament and actin filament cross-linker protein
            isoform b [Homo sapiens]
          Length = 5938

 Score = 30.0 bits (66), Expect = 2.3
 Identities = 38/145 (26%), Positives = 56/145 (38%), Gaps = 10/145 (6%)

Query: 16   RTLHLQTGNLLN-WGRLRKKCPSTHSEELHDCIQKTLN-EWSSQINPDLVREFPDVLECT 73
            RTL  Q   L N W  L KK     S  L DC+QK    +W  +   DLV    D  +  
Sbjct: 3311 RTLQNQLVELKNHWEELSKKTADRQSR-LKDCMQKAQKYQWHVE---DLVPWIED-CKAK 3365

Query: 74   VSHAVEKINPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVL---GVAQLDSVIIASP 130
            +S     ++P + E   + +K  + E     S    ++ A  +L     A  D +     
Sbjct: 3366 MSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKA 3425

Query: 131  PIEDGVNLSLEHLQPYWEELENLVQ 155
             I   ++   E LQ     LE + Q
Sbjct: 3426 GINQNMDAVTEELQAKTGSLEEMTQ 3450


>gi|33188445 microfilament and actin filament cross-linker protein
            isoform a [Homo sapiens]
          Length = 5430

 Score = 30.0 bits (66), Expect = 2.3
 Identities = 38/145 (26%), Positives = 56/145 (38%), Gaps = 10/145 (6%)

Query: 16   RTLHLQTGNLLN-WGRLRKKCPSTHSEELHDCIQKTLN-EWSSQINPDLVREFPDVLECT 73
            RTL  Q   L N W  L KK     S  L DC+QK    +W  +   DLV    D  +  
Sbjct: 2809 RTLQNQLVELKNHWEELSKKTADRQSR-LKDCMQKAQKYQWHVE---DLVPWIED-CKAK 2863

Query: 74   VSHAVEKINPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVL---GVAQLDSVIIASP 130
            +S     ++P + E   + +K  + E     S    ++ A  +L     A  D +     
Sbjct: 2864 MSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKA 2923

Query: 131  PIEDGVNLSLEHLQPYWEELENLVQ 155
             I   ++   E LQ     LE + Q
Sbjct: 2924 GINQNMDAVTEELQAKTGSLEEMTQ 2948


>gi|4502049 aldo-keto reductase family 1, member B1 [Homo sapiens]
          Length = 316

 Score = 30.0 bits (66), Expect = 2.3
 Identities = 29/118 (24%), Positives = 52/118 (44%), Gaps = 15/118 (12%)

Query: 85  EREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVAQLDSVIIASP----------PIED 134
           +REE+ + +KL+    +     + A     S L +  LD  +I  P          P+++
Sbjct: 69  KREELFIVSKLWCTY-HEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDE 127

Query: 135 GVNL--SLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQ--WAQVKPNSNQV 188
             N+  S  ++   W  +E LV    + AIG S+ +  Q+E +      + KP  NQ+
Sbjct: 128 SGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQI 185


>gi|10863929 ribonuclease L [Homo sapiens]
          Length = 741

 Score = 29.6 bits (65), Expect = 3.0
 Identities = 16/57 (28%), Positives = 28/57 (49%)

Query: 102 SSSSTRSAVDMACSVLGVAQLDSVIIASPPIEDGVNLSLEHLQPYWEELENLVQSKK 158
           SSS  R+AV+    ++   Q + V +    +E G N++ +  +  W  L N VQ  +
Sbjct: 15  SSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSR 71


>gi|5174695 aldo-keto reductase family 1, member D1 [Homo sapiens]
          Length = 326

 Score = 29.6 bits (65), Expect = 3.0
 Identities = 20/71 (28%), Positives = 34/71 (47%), Gaps = 3/71 (4%)

Query: 147 WEELENLVQSKKIVAIGTSDLDKTQLEQLYQ--WAQVKPNSNQVNLASCCVMPPDLTAFA 204
           WE +E    +  + ++G S+ ++ QLE +      + KP SNQV         P L  F 
Sbjct: 151 WEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSNQVECHPYFTQ-PKLLKFC 209

Query: 205 KQFDIQLLTHN 215
           +Q DI +  ++
Sbjct: 210 QQHDIVITAYS 220


>gi|66346733 chloride intracellular channel 2 [Homo sapiens]
          Length = 247

 Score = 29.6 bits (65), Expect = 3.0
 Identities = 15/51 (29%), Positives = 28/51 (54%)

Query: 47  IQKTLNEWSSQINPDLVREFPDVLECTVSHAVEKINPDEREEMKVSAKLFI 97
           I+ T  E +      L++EF  + +   +  +++I+PD  EE  VS +LF+
Sbjct: 124 IKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFL 174


>gi|93277124 aldo-keto reductase family 1, member C-like 2 [Homo
           sapiens]
          Length = 320

 Score = 29.3 bits (64), Expect = 3.9
 Identities = 16/44 (36%), Positives = 26/44 (59%), Gaps = 2/44 (4%)

Query: 147 WEELENLVQSKKIVAIGTSDLDKTQLEQLYQ--WAQVKPNSNQV 188
           WE +E+LV +  +  IG S+ +  QLE+L      + KP +NQ+
Sbjct: 152 WEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQI 195


>gi|73623035 sperm associated antigen 5 [Homo sapiens]
          Length = 1193

 Score = 29.3 bits (64), Expect = 3.9
 Identities = 42/168 (25%), Positives = 65/168 (38%), Gaps = 37/168 (22%)

Query: 97  IVESNSSSSTRSAVDMACSVLGVAQLDSVIIASPPIEDGVNLSLEHLQPYWEELENLVQS 156
           +VE  S  +   AV+    +LG +  +S +     +E GVN S+         LENL QS
Sbjct: 312 LVEMESQEAPGPAVEDVGRILG-SDTESWMSPLAWLEKGVNTSVM--------LENLRQS 362

Query: 157 KKI------VAIGTSDLDKTQLEQLYQWA---QVKPNSNQVNLASC-----------CVM 196
             +       AIGT+      +   +  +   +   N++Q  L              C  
Sbjct: 363 LSLPSMLRDAAIGTTPFSTCSVGTWFTPSAPQEKSTNTSQTGLVGTKHSTSETEQLLCGR 422

Query: 197 PPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIQAHEWVP 244
           PPDLTA ++        H+    LLS     E L   + D ++   VP
Sbjct: 423 PPDLTALSR--------HDLEDNLLSSLVILEVLSRQLRDWKSQLAVP 462


>gi|156105697 ring finger and CCCH-type zinc finger domains 2
           isoform 1 [Homo sapiens]
          Length = 1191

 Score = 29.3 bits (64), Expect = 3.9
 Identities = 14/43 (32%), Positives = 23/43 (53%)

Query: 143 LQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNS 185
           + P WE+LEN + + K V  G  D  +    + ++  Q +PNS
Sbjct: 367 VSPTWEQLENAMVAVKTVVHGLVDFIQNYSRKGHETPQPQPNS 409


>gi|156105699 ring finger and CCCH-type zinc finger domains 2
           isoform 2 [Homo sapiens]
          Length = 1064

 Score = 29.3 bits (64), Expect = 3.9
 Identities = 14/43 (32%), Positives = 23/43 (53%)

Query: 143 LQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQVKPNS 185
           + P WE+LEN + + K V  G  D  +    + ++  Q +PNS
Sbjct: 367 VSPTWEQLENAMVAVKTVVHGLVDFIQNYSRKGHETPQPQPNS 409


>gi|48762700 GTF2I repeat domain containing 2 [Homo sapiens]
          Length = 949

 Score = 28.5 bits (62), Expect = 6.6
 Identities = 26/85 (30%), Positives = 38/85 (44%), Gaps = 12/85 (14%)

Query: 79  EKINPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVAQLDSVIIASPPIEDGVNL 138
           E+ N D   E+K+        +NSSS T SA        GV  L+ V +  P  E     
Sbjct: 277 EEPNEDPEAEVKIEGN-----TNSSSVTNSAA-------GVEDLNIVQVTVPDNEKERLS 324

Query: 139 SLEHLQPYWEELENLVQSKKIVAIG 163
           S+E ++   E++ +L   K   AIG
Sbjct: 325 SIEKIKQLREQVNDLFSRKFGEAIG 349


>gi|51241788 GTF2I repeat domain containing 2B [Homo sapiens]
          Length = 949

 Score = 28.5 bits (62), Expect = 6.6
 Identities = 26/85 (30%), Positives = 38/85 (44%), Gaps = 12/85 (14%)

Query: 79  EKINPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVAQLDSVIIASPPIEDGVNL 138
           E+ N D   E+K+        +NSSS T SA        GV  L+ V +  P  E     
Sbjct: 277 EEPNEDPEAEVKIEGN-----TNSSSVTNSAA-------GVEDLNIVQVTVPDNEKERLS 324

Query: 139 SLEHLQPYWEELENLVQSKKIVAIG 163
           S+E ++   E++ +L   K   AIG
Sbjct: 325 SIEKIKQLREQVNDLFSRKFGEAIG 349


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.129    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,915,682
Number of Sequences: 37866
Number of extensions: 394060
Number of successful extensions: 1170
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 1162
Number of HSP's gapped (non-prelim): 25
length of query: 274
length of database: 18,247,518
effective HSP length: 101
effective length of query: 173
effective length of database: 14,423,052
effective search space: 2495187996
effective search space used: 2495187996
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.