Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 4503711
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503711 fibroblast growth factor receptor 3 isoform 1
precursor [Homo sapiens]
(806 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 1637 0.0
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 1556 0.0
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 1061 0.0
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 1023 0.0
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 1018 0.0
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 1013 0.0
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 1013 0.0
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 1009 0.0
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 986 0.0
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 982 0.0
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 979 0.0
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 972 0.0
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 936 0.0
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 922 0.0
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 922 0.0
gi|13186249 fibroblast growth factor receptor 1 isoform 9 precur... 918 0.0
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 885 0.0
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 790 0.0
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 690 0.0
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 647 0.0
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 328 9e-90
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 328 2e-89
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 328 2e-89
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 311 2e-84
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge... 287 3e-77
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene... 287 3e-77
gi|13186241 fibroblast growth factor receptor 1 isoform 6 precur... 277 2e-74
gi|13186238 fibroblast growth factor receptor 1 isoform 5 precur... 273 4e-73
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap... 249 5e-66
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like... 249 5e-66
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 1637 bits (4239), Expect = 0.0
Identities = 806/806 (100%), Positives = 806/806 (100%)
Query: 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS 60
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS
Sbjct: 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS 60
Query: 61 CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH 120
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH
Sbjct: 61 CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH 120
Query: 121 FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
Sbjct: 121 FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
Query: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
Sbjct: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
Query: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
Sbjct: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
Query: 301 DGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAE 360
DGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAE
Sbjct: 301 DGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAE 360
Query: 361 EELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLK 420
EELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLK
Sbjct: 361 EELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLK 420
Query: 421 RQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGE 480
RQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGE
Sbjct: 421 RQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGE 480
Query: 481 GCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIIN 540
GCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIIN
Sbjct: 481 GCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIIN 540
Query: 541 LLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQ 600
LLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQ
Sbjct: 541 LLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQ 600
Query: 601 VARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKW 660
VARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKW
Sbjct: 601 VARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKW 660
Query: 661 MAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT 720
MAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT
Sbjct: 661 MAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT 720
Query: 721 HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSS 780
HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSS
Sbjct: 721 HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSS 780
Query: 781 SSSGDDSVFAHDLLPPAPPSSGGSRT 806
SSSGDDSVFAHDLLPPAPPSSGGSRT
Sbjct: 781 SSSGDDSVFAHDLLPPAPPSSGGSRT 806
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 1556 bits (4030), Expect = 0.0
Identities = 774/809 (95%), Positives = 783/809 (96%), Gaps = 4/809 (0%)
Query: 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS 60
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS
Sbjct: 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS 60
Query: 61 CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH 120
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH
Sbjct: 61 CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH 120
Query: 121 FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
Sbjct: 121 FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
Query: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
Sbjct: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
Query: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
Sbjct: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
Query: 301 DGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVV---L 357
DGTPYVTVLK+ + + + ++ L L NV+ D GEY C A N IG + + WL V
Sbjct: 301 DGTPYVTVLKSWISESVEADVR-LRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPR 359
Query: 358 PAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRF 417
AEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRF
Sbjct: 360 AAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRF 419
Query: 418 PLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKP 477
PLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKP
Sbjct: 420 PLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKP 479
Query: 478 LGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 537
LGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN
Sbjct: 480 LGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 539
Query: 538 IINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSC 597
IINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSC
Sbjct: 540 IINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSC 599
Query: 598 AYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLP 657
AYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLP
Sbjct: 600 AYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLP 659
Query: 658 VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 717
VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA
Sbjct: 660 VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 719
Query: 718 NCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDT 777
NCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDT
Sbjct: 720 NCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDT 779
Query: 778 PSSSSSGDDSVFAHDLLPPAPPSSGGSRT 806
PSSSSSGDDSVFAHDLLPPAPPSSGGSRT
Sbjct: 780 PSSSSSGDDSVFAHDLLPPAPPSSGGSRT 808
>gi|221316639 fibroblast growth factor receptor 2 isoform 1
precursor [Homo sapiens]
Length = 821
Score = 1061 bits (2743), Expect = 0.0
Identities = 536/769 (69%), Positives = 616/769 (80%), Gaps = 22/769 (2%)
Query: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Query: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
Query: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
Query: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
PSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYS
Sbjct: 223 PSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYS 282
Query: 280 DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTC 339
DAQPHIQW+KHVE NGSK GPDG PY+ VLK AG NTTDKE+EVL + NVTFEDAGEYTC
Sbjct: 283 DAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTC 342
Query: 340 LAGNSIGFSHHSAWLVVLPA---EEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLC 396
LAGNSIG S HSAWL VLPA E+E+ + + Y I Y +G FL +V V LC
Sbjct: 343 LAGNSIGISFHSAWLTVLPAPGREKEITASPD----YLEIAIYCIGVFLIACMVVTVILC 398
Query: 397 RLRSPPKKG--LGSPTVHKIS-RFPLKRQV--SLESNASMSSNTPLVRIA-RLSS-GEGP 449
R+++ KK P VHK++ R PL+RQV S ES++SM+SNTPLVRI RLSS + P
Sbjct: 399 RMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTP 458
Query: 450 TLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKM 509
LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+ + VTVAVKM
Sbjct: 459 MLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKM 518
Query: 510 LKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRA 569
LKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+LRA
Sbjct: 519 LKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRA 578
Query: 570 RRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDN 629
RRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLAARNVLVTE+N
Sbjct: 579 RRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN 638
Query: 630 VMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFT 689
VMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL+WEIFT
Sbjct: 639 VMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT 698
Query: 690 LGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLD 749
LGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRPTFKQLVEDLD
Sbjct: 699 LGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD 758
Query: 750 RVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 798
R+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D +P P
Sbjct: 759 RILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 807
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 1023 bits (2644), Expect = 0.0
Identities = 521/768 (67%), Positives = 604/768 (78%), Gaps = 19/768 (2%)
Query: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Query: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
Query: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
Query: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
PSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYS
Sbjct: 223 PSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYS 282
Query: 280 DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTC 339
DAQPHIQW+KHVE NGSK GPDG PY+ VLK +G N+++ E VL+L NVT DAGEY C
Sbjct: 283 DAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYIC 340
Query: 340 LAGNSIGFSHHSAWLVVLPAEEELVEADE--AGSVYAGILSYGVGFFLFILVVAAVTLCR 397
N IG ++ SAWL VLP ++ E A Y I Y +G FL +V V LCR
Sbjct: 341 KVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCR 400
Query: 398 LRSPPKKG--LGSPTVHKIS-RFPLKRQV--SLESNASMSSNTPLVRIA-RLSS-GEGPT 450
+++ KK P VHK++ R PL+RQV S ES++SM+SNTPLVRI RLSS + P
Sbjct: 401 MKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPM 460
Query: 451 LANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKML 510
LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+ + VTVAVKML
Sbjct: 461 LAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKML 520
Query: 511 KDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRAR 570
KDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+LRAR
Sbjct: 521 KDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRAR 580
Query: 571 RPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNV 630
RPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLAARNVLVTE+NV
Sbjct: 581 RPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV 640
Query: 631 MKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTL 690
MKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL+WEIFTL
Sbjct: 641 MKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTL 700
Query: 691 GGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDR 750
GGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRPTFKQLVEDLDR
Sbjct: 701 GGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR 760
Query: 751 VLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 798
+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D +P P
Sbjct: 761 ILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 808
>gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
Length = 704
Score = 1018 bits (2631), Expect = 0.0
Identities = 501/666 (75%), Positives = 569/666 (85%), Gaps = 13/666 (1%)
Query: 142 EDTGVDT-GAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHR 200
EDT ++ GAPYWT E+M+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHR
Sbjct: 29 EDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR 88
Query: 201 IGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLP 260
IGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLP
Sbjct: 89 IGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLP 148
Query: 261 ANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKE 320
AN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG PY+ VLK AG NTTDKE
Sbjct: 149 ANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKE 208
Query: 321 LEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPA---EEELVEADEAGSVYAGIL 377
+EVL + NVTFEDAGEYTCLAGNSIG S HSAWL VLPA E+E+ + + Y I
Sbjct: 209 IEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPD----YLEIA 264
Query: 378 SYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKIS-RFPLKRQVSLESNASMSSN 434
Y +G FL +V V LCR+++ KK P VHK++ R PL+RQVS ES++SM+SN
Sbjct: 265 IYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSN 324
Query: 435 TPLVRIA-RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAI 492
TPLVRI RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+
Sbjct: 325 TPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAV 384
Query: 493 GIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLY 552
GIDKD+ + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLY
Sbjct: 385 GIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLY 444
Query: 553 VLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQK 612
V+VEYA+KGNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQK
Sbjct: 445 VIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQK 504
Query: 613 CIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYT 672
CIHRDLAARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYT
Sbjct: 505 CIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYT 564
Query: 673 HQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWH 732
HQSDVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWH
Sbjct: 565 HQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWH 624
Query: 733 AAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHD 792
A PSQRPTFKQLVEDLDR+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D
Sbjct: 625 AVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPD 684
Query: 793 LLPPAP 798
+P P
Sbjct: 685 PMPYEP 690
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 1013 bits (2619), Expect = 0.0
Identities = 508/774 (65%), Positives = 608/774 (78%), Gaps = 17/774 (2%)
Query: 39 PGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLN 98
P P + E + GD ++L C + W++DG L S R + + ++V +
Sbjct: 33 PWGAPVEVESFLVHPGDLLQLRCRLRDD--VQSINWLRDGVQLAESNRTRITGEEVEVQD 90
Query: 99 ASHEDSGAYSC-RQRLTQRVLCHFSVRVTDA-PSSGDDEDGED------EAEDTGVDTGA 150
+ DSG Y+C + +FSV V+DA PSS DD+D +D E ++T + A
Sbjct: 91 SVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVA 150
Query: 151 PYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQ 210
PYWT PE+M+KKL AVPAA TV+F+CP++G P P++ WLKNG+EF+ +HRIGG K+R+
Sbjct: 151 PYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYAT 210
Query: 211 WSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSD 270
WS++M+SVVPSD+GNYTC+VEN++GSI TY LDV+ERSPHRPILQAGLPAN+T LGS+
Sbjct: 211 WSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSN 270
Query: 271 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVT 330
VEF CKVYSD QPHIQWLKH+EVNGSK+GPD PYV +LKTAG NTTDKE+EVL L NV+
Sbjct: 271 VEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVS 330
Query: 331 FEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVV 390
FEDAGEYTCLAGNSIG SHHSAWL VL A EE A +Y I+ Y G FL +V
Sbjct: 331 FEDAGEYTCLAGNSIGLSHHSAWLTVLEALEER-PAVMTSPLYLEIIIYCTGAFLISCMV 389
Query: 391 AAVTLCRLRSPPKKG--LGSPTVHKISR-FPLKRQV--SLESNASMSSNTPLVRIARLSS 445
+V + +++S KK VHK+++ PL+RQV S +S+ASM+S LVR +RLSS
Sbjct: 390 GSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSS 449
Query: 446 GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTV 505
P LA VSE ELP DP+WEL R RL LGKPLGEGCFGQVV+AEAIG+DKD+ + V
Sbjct: 450 SGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKV 509
Query: 506 AVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLRE 565
AVKMLK DAT+KDLSDL+SEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE
Sbjct: 510 AVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLRE 569
Query: 566 FLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLV 625
+L+ARRPPGL+Y ++ PEEQL+ KDLVSCAYQVARGMEYLAS+KCIHRDLAARNVLV
Sbjct: 570 YLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV 629
Query: 626 TEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLW 685
TEDNVMKIADFGLARD+H++DYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVLLW
Sbjct: 630 TEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLW 689
Query: 686 EIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLV 745
EIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCT++LYM+MR+CWHA PSQRPTFKQLV
Sbjct: 690 EIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLV 749
Query: 746 EDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSS-SSGDDSVFAHDLLPPAP 798
EDLDR++ +TS EYLDLS P +QYSP DT SS+ SSG+DSVF+H+ LP P
Sbjct: 750 EDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEP 803
>gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
Length = 706
Score = 1013 bits (2618), Expect = 0.0
Identities = 501/668 (75%), Positives = 569/668 (85%), Gaps = 15/668 (2%)
Query: 142 EDTGVDT-GAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHR 200
EDT ++ GAPYWT E+M+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHR
Sbjct: 29 EDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHR 88
Query: 201 IGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLP 260
IGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLP
Sbjct: 89 IGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLP 148
Query: 261 ANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKE 320
AN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG PY+ VLK AG NTTDKE
Sbjct: 149 ANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKE 208
Query: 321 LEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPA---EEELVEADEAGSVYAGIL 377
+EVL + NVTFEDAGEYTCLAGNSIG S HSAWL VLPA E+E+ + + Y I
Sbjct: 209 IEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPD----YLEIA 264
Query: 378 SYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKIS-RFPLKRQV--SLESNASMS 432
Y +G FL +V V LCR+++ KK P VHK++ R PL+RQV S ES++SM+
Sbjct: 265 IYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMN 324
Query: 433 SNTPLVRIA-RLSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAE 490
SNTPLVRI RLSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAE
Sbjct: 325 SNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAE 384
Query: 491 AIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGP 550
A+GIDKD+ + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GP
Sbjct: 385 AVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGP 444
Query: 551 LYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLAS 610
LYV+VEYA+KGNLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLAS
Sbjct: 445 LYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS 504
Query: 611 QKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRV 670
QKCIHRDLAARNVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRV
Sbjct: 505 QKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRV 564
Query: 671 YTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMREC 730
YTHQSDVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+C
Sbjct: 565 YTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDC 624
Query: 731 WHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFA 790
WHA PSQRPTFKQLVEDLDR+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+
Sbjct: 625 WHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFS 684
Query: 791 HDLLPPAP 798
D +P P
Sbjct: 685 PDPMPYEP 692
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 1009 bits (2609), Expect = 0.0
Identities = 504/776 (64%), Positives = 605/776 (77%), Gaps = 19/776 (2%)
Query: 39 PGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLN 98
P P + E + GD ++L C + W++DG L S R + + ++V +
Sbjct: 33 PWGAPVEVESFLVHPGDLLQLRCRLRDD--VQSINWLRDGVQLAESNRTRITGEEVEVQD 90
Query: 99 ASHEDSGAYSC-RQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG-------- 149
+ DSG Y+C + +FSV V+DA S +D+D +D++ +T
Sbjct: 91 SVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMP 150
Query: 150 -APYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRH 208
APYWT PE+M+KKL AVPAA TV+F+CP++G P P++ WLKNG+EF+ +HRIGG K+R+
Sbjct: 151 VAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRY 210
Query: 209 QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLG 268
WS++M+SVVPSD+GNYTC+VEN++GSI TY LDV+ERSPHRPILQAGLPAN+T LG
Sbjct: 211 ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALG 270
Query: 269 SDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHN 328
S+VEF CKVYSD QPHIQWLKH+EVNGSK+GPD PYV +LKTAG NTTDKE+EVL L N
Sbjct: 271 SNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRN 330
Query: 329 VTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFIL 388
V+FEDAGEYTCLAGNSIG SHHSAWL VL A EE A +Y I+ Y G FL
Sbjct: 331 VSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEER-PAVMTSPLYLEIIIYCTGAFLISC 389
Query: 389 VVAAVTLCRLRSPPKKG--LGSPTVHKISR-FPLKRQV--SLESNASMSSNTPLVRIARL 443
+V +V + +++S KK VHK+++ PL+RQV S +S+ASM+S LVR +RL
Sbjct: 390 MVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRL 449
Query: 444 SSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPV 503
SS P LA VSE ELP DP+WEL R RL LGKPLGEGCFGQVV+AEAIG+DKD+ +
Sbjct: 450 SSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 509
Query: 504 TVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNL 563
VAVKMLK DAT+KDLSDL+SEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGNL
Sbjct: 510 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 569
Query: 564 REFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNV 623
RE+L+ARRPPGL+Y ++ PEEQL+ KDLVSCAYQVARGMEYLAS+KCIHRDLAARNV
Sbjct: 570 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 629
Query: 624 LVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 683
LVTEDNVMKIADFGLARD+H++DYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL
Sbjct: 630 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 689
Query: 684 LWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQ 743
LWEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+NCT++LYM+MR+CWHA PSQRPTFKQ
Sbjct: 690 LWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 749
Query: 744 LVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSS-SSGDDSVFAHDLLPPAP 798
LVEDLDR++ +TS EYLDLS P +QYSP DT SS+ SSG+DSVF+H+ LP P
Sbjct: 750 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEP 805
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 986 bits (2549), Expect = 0.0
Identities = 483/682 (70%), Positives = 566/682 (82%), Gaps = 13/682 (1%)
Query: 129 PSSGDDEDGED------EAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNP 182
PSS DD+D +D E ++T + APYWT PE+M+KKL AVPAA TV+F+CP++G P
Sbjct: 34 PSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTP 93
Query: 183 TPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYT 242
P++ WLKNG+EF+ +HRIGG K+R+ WS++M+SVVPSD+GNYTC+VEN++GSI TY
Sbjct: 94 NPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQ 153
Query: 243 LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDG 302
LDV+ERSPHRPILQAGLPAN+T LGS+VEF CKVYSD QPHIQWLKH+EVNGSK+GPD
Sbjct: 154 LDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDN 213
Query: 303 TPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEE 362
PYV +LKTAG NTTDKE+EVL L NV+FEDAGEYTCLAGNSIG SHHSAWL VL A EE
Sbjct: 214 LPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEE 273
Query: 363 LVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKISR-FPL 419
A +Y I+ Y G FL +V +V + +++S KK VHK+++ PL
Sbjct: 274 R-PAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPL 332
Query: 420 KRQV--SLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKP 477
+RQV S +S+ASM+S LVR +RLSS P LA VSE ELP DP+WEL R RL LGKP
Sbjct: 333 RRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKP 392
Query: 478 LGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 537
LGEGCFGQVV+AEAIG+DKD+ + VAVKMLK DAT+KDLSDL+SEMEMMKMIGKHKN
Sbjct: 393 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 452
Query: 538 IINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSC 597
IINLLGACTQ GPLYV+VEYA+KGNLRE+L+ARRPPGL+Y ++ PEEQL+ KDLVSC
Sbjct: 453 IINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSC 512
Query: 598 AYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLP 657
AYQVARGMEYLAS+KCIHRDLAARNVLVTEDNVMKIADFGLARD+H++DYYKKTTNGRLP
Sbjct: 513 AYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLP 572
Query: 658 VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 717
VKWMAPEALFDR+YTHQSDVWSFGVLLWEIFTLGGSPYPG+PVEELFKLLKEGHRMDKP+
Sbjct: 573 VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPS 632
Query: 718 NCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDT 777
NCT++LYM+MR+CWHA PSQRPTFKQLVEDLDR++ +TS EYLDLS P +QYSP DT
Sbjct: 633 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDT 692
Query: 778 PSSS-SSGDDSVFAHDLLPPAP 798
SS+ SSG+DSVF+H+ LP P
Sbjct: 693 RSSTCSSGEDSVFSHEPLPEEP 714
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 982 bits (2539), Expect = 0.0
Identities = 483/684 (70%), Positives = 565/684 (82%), Gaps = 15/684 (2%)
Query: 129 PSSGDDEDGEDEA-EDTGVDTG-------APYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
PSS DD+D +D + E+ D APYWT PE+M+KKL AVPAA TV+F+CP++G
Sbjct: 34 PSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSG 93
Query: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
P P++ WLKNG+EF+ +HRIGG K+R+ WS++M+SVVPSD+GNYTC+VEN++GSI T
Sbjct: 94 TPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHT 153
Query: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
Y LDV+ERSPHRPILQAGLPAN+T LGS+VEF CKVYSD QPHIQWLKH+EVNGSK+GP
Sbjct: 154 YQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP 213
Query: 301 DGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAE 360
D PYV +LKTAG NTTDKE+EVL L NV+FEDAGEYTCLAGNSIG SHHSAWL VL A
Sbjct: 214 DNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEAL 273
Query: 361 EELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKISR-F 417
EE A +Y I+ Y G FL +V +V + +++S KK VHK+++
Sbjct: 274 EER-PAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSI 332
Query: 418 PLKRQV--SLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLG 475
PL+RQV S +S+ASM+S LVR +RLSS P LA VSE ELP DP+WEL R RL LG
Sbjct: 333 PLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLG 392
Query: 476 KPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKH 535
KPLGEGCFGQVV+AEAIG+DKD+ + VAVKMLK DAT+KDLSDL+SEMEMMKMIGKH
Sbjct: 393 KPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKH 452
Query: 536 KNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLV 595
KNIINLLGACTQ GPLYV+VEYA+KGNLRE+L+ARRPPGL+Y ++ PEEQL+ KDLV
Sbjct: 453 KNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLV 512
Query: 596 SCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGR 655
SCAYQVARGMEYLAS+KCIHRDLAARNVLVTEDNVMKIADFGLARD+H++DYYKKTTNGR
Sbjct: 513 SCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGR 572
Query: 656 LPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 715
LPVKWMAPEALFDR+YTHQSDVWSFGVLLWEIFTLGGSPYPG+PVEELFKLLKEGHRMDK
Sbjct: 573 LPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDK 632
Query: 716 PANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQ 775
P+NCT++LYM+MR+CWHA PSQRPTFKQLVEDLDR++ +TS EYLDLS P +QYSP
Sbjct: 633 PSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFP 692
Query: 776 DTPSSS-SSGDDSVFAHDLLPPAP 798
DT SS+ SSG+DSVF+H+ LP P
Sbjct: 693 DTRSSTCSSGEDSVFSHEPLPEEP 716
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 979 bits (2530), Expect = 0.0
Identities = 486/660 (73%), Positives = 554/660 (83%), Gaps = 18/660 (2%)
Query: 127 DAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERMDKKLLAVPAANTVRFRCPAAGNP 182
DA SSGDDED D AED + APYWT E+M+K+L AVPAANTV+FRCPA GNP
Sbjct: 37 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 96
Query: 183 TPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYT 242
P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI TY
Sbjct: 97 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 156
Query: 243 LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDG 302
LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG
Sbjct: 157 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 216
Query: 303 TPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPA--- 359
PY+ VLK AG NTTDKE+EVL + NVTFEDAGEYTCLAGNSIG S HSAWL VLPA
Sbjct: 217 LPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGR 276
Query: 360 EEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKIS-R 416
E+E+ + + Y I Y +G FL +V V LCR+++ KK P VHK++ R
Sbjct: 277 EKEITASPD----YLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKR 332
Query: 417 FPLKRQV--SLESNASMSSNTPLVRIA-RLSS-GEGPTLANVSELELPADPKWELSRARL 472
PL+RQV S ES++SM+SNTPLVRI RLSS + P LA VSE ELP DPKWE R +L
Sbjct: 333 IPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKL 392
Query: 473 TLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMI 532
TLGKPLGEGCFGQVVMAEA+GIDKD+ + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMI
Sbjct: 393 TLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMI 452
Query: 533 GKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFK 592
GKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+LRARRPPG++YS+D + PEEQ+TFK
Sbjct: 453 GKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFK 512
Query: 593 DLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTT 652
DLVSC YQ+ARGMEYLASQKCIHRDLAARNVLVTE+NVMKIADFGLARD++N+DYYKKTT
Sbjct: 513 DLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTT 572
Query: 653 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHR 712
NGRLPVKWMAPEALFDRVYTHQSDVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHR
Sbjct: 573 NGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHR 632
Query: 713 MDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSP 772
MDKPANCT++LYM+MR+CWHA PSQRPTFKQLVEDLDR+LT+T+ +E +S + + P
Sbjct: 633 MDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEEKKVSGAVDCHKP 692
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 973 bits (2514), Expect = 0.0
Identities = 494/728 (67%), Positives = 575/728 (78%), Gaps = 19/728 (2%)
Query: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Query: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
Query: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
Query: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
PSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYS
Sbjct: 223 PSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYS 282
Query: 280 DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTC 339
DAQPHIQW+KHVE NGSK GPDG PY+ VLK +G N+++ E VL+L NVT DAGEY C
Sbjct: 283 DAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYIC 340
Query: 340 LAGNSIGFSHHSAWLVVLPAEEELVEADE--AGSVYAGILSYGVGFFLFILVVAAVTLCR 397
N IG ++ SAWL VLP ++ E A Y I Y +G FL +V V LCR
Sbjct: 341 KVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCR 400
Query: 398 LRSPPKKG--LGSPTVHKIS-RFPLKRQV--SLESNASMSSNTPLVRIA-RLSS-GEGPT 450
+++ KK P VHK++ R PL+RQV S ES++SM+SNTPLVRI RLSS + P
Sbjct: 401 MKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPM 460
Query: 451 LANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKML 510
LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+ + VTVAVKML
Sbjct: 461 LAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKML 520
Query: 511 KDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRAR 570
KDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+LRAR
Sbjct: 521 KDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRAR 580
Query: 571 RPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNV 630
RPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLAARNVLVTE+NV
Sbjct: 581 RPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNV 640
Query: 631 MKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTL 690
MKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL+WEIFTL
Sbjct: 641 MKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTL 700
Query: 691 GGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDR 750
GGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRPTFKQLVEDLDR
Sbjct: 701 GGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR 760
Query: 751 VLTVTSTD 758
+LT+T+ +
Sbjct: 761 ILTLTTNE 768
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 936 bits (2420), Expect = 0.0
Identities = 468/645 (72%), Positives = 536/645 (83%), Gaps = 15/645 (2%)
Query: 127 DAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERMDKKLLAVPAANTVRFRCPAAGNP 182
DA SSGDDED D AED + APYWT E+M+K+L AVPAANTV+FRCPA GNP
Sbjct: 37 DAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNP 96
Query: 183 TPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYT 242
P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVVPSD+GNYTCVVEN++GSI TY
Sbjct: 97 MPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYH 156
Query: 243 LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDG 302
LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYSDAQPHIQW+KHVE NGSK GPDG
Sbjct: 157 LDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDG 216
Query: 303 TPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEE 362
PY+ VLK +G N+++ E VL+L NVT DAGEY C N IG ++ SAWL VLP ++
Sbjct: 217 LPYLKVLKHSGINSSNAE--VLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQA 274
Query: 363 LVEADE--AGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKG--LGSPTVHKIS-RF 417
E A Y I Y +G FL +V V LCR+++ KK P VHK++ R
Sbjct: 275 PGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRI 334
Query: 418 PLKRQV--SLESNASMSSNTPLVRIA-RLSS-GEGPTLANVSELELPADPKWELSRARLT 473
PL+RQV S ES++SM+SNTPLVRI RLSS + P LA VSE ELP DPKWE R +LT
Sbjct: 335 PLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT 394
Query: 474 LGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIG 533
LGKPLGEGCFGQVVMAEA+GIDKD+ + VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIG
Sbjct: 395 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG 454
Query: 534 KHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKD 593
KHKNIINLLGACTQ GPLYV+VEYA+KGNLRE+LRARRPPG++YS+D + PEEQ+TFKD
Sbjct: 455 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKD 514
Query: 594 LVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTN 653
LVSC YQ+ARGMEYLASQKCIHRDLAARNVLVTE+NVMKIADFGLARD++N+DYYKKTTN
Sbjct: 515 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTN 574
Query: 654 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRM 713
GRLPVKWMAPEALFDRVYTHQSDVWSFGVL+WEIFTLGGSPYPGIPVEELFKLLKEGHRM
Sbjct: 575 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRM 634
Query: 714 DKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTD 758
DKPANCT++LYM+MR+CWHA PSQRPTFKQLVEDLDR+LT+T+ +
Sbjct: 635 DKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 679
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 922 bits (2383), Expect = 0.0
Identities = 495/793 (62%), Positives = 572/793 (72%), Gaps = 14/793 (1%)
Query: 8 LALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGG 67
LAL + V G SL + V P E Q+++L G V L C G
Sbjct: 5 LALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQ-QEQELTVALGQPVRLCCGRAERG 63
Query: 68 PMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTD 127
W K+G+ L P+ RV RL++ + ED+G Y C R + VL + ++ D
Sbjct: 64 GH----WYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGD 119
Query: 128 A-PSSGDDEDGE---DEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPT 183
+ SS DDED + D + APYWT P+RM+KKL AVPA NTV+FRCPAAGNPT
Sbjct: 120 SLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPT 179
Query: 184 PSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTL 243
P+I WLK+G+ F GE+RIGGI+LRHQ WSLVMESVVPSDRG YTC+VEN GSIR Y L
Sbjct: 180 PTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLL 239
Query: 244 DVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT 303
DVLERSPHRPILQAGLPAN TAV+GSDVE CKVYSDAQPHIQWLKH+ +NGS G DG
Sbjct: 240 DVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGF 299
Query: 304 PYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEEL 363
PYV VLKTA N++ E+EVL L NV+ EDAGEYTCLAGNSIG S+ SAWL VLP E+
Sbjct: 300 PYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPT 357
Query: 364 VEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSP-TVHKISRFPLKRQ 422
A + Y I+ Y G +++ L R ++ + P TV K+SRFPL RQ
Sbjct: 358 WTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQ 417
Query: 423 VSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGC 482
SLES +S S++ LVR RLSS LA + L+LP DP WE R RL LGKPLGEGC
Sbjct: 418 FSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGC 477
Query: 483 FGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLL 542
FGQVV AEA G+D R + TVAVKMLKD+A+DKDL+DLVSEME+MK+IG+HKNIINLL
Sbjct: 478 FGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLL 537
Query: 543 GACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVA 602
G CTQ GPLYV+VE AAKGNLREFLRARRPPG D S D + E L+F LVSCAYQVA
Sbjct: 538 GVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVA 597
Query: 603 RGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMA 662
RGM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR VH++DYYKKT+NGRLPVKWMA
Sbjct: 598 RGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMA 657
Query: 663 PEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHD 722
PEALFDRVYTHQSDVWSFG+LLWEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C +
Sbjct: 658 PEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPE 717
Query: 723 LYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSS 782
LY +MRECWHAAPSQRPTFKQLVE LD+VL S +EYLDL F YSP G D SS+
Sbjct: 718 LYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVS-EEYLDLRLTFGPYSPSGGDA-SSTC 775
Query: 783 SGDDSVFAHDLLP 795
S DSVF+HD LP
Sbjct: 776 SSSDSVFSHDPLP 788
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 922 bits (2383), Expect = 0.0
Identities = 495/793 (62%), Positives = 572/793 (72%), Gaps = 14/793 (1%)
Query: 8 LALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGG 67
LAL + V G SL + V P E Q+++L G V L C G
Sbjct: 5 LALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQ-QEQELTVALGQPVRLCCGRAERG 63
Query: 68 PMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTD 127
W K+G+ L P+ RV RL++ + ED+G Y C R + VL + ++ D
Sbjct: 64 GH----WYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGD 119
Query: 128 A-PSSGDDEDGE---DEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPT 183
+ SS DDED + D + APYWT P+RM+KKL AVPA NTV+FRCPAAGNPT
Sbjct: 120 SLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPT 179
Query: 184 PSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTL 243
P+I WLK+G+ F GE+RIGGI+LRHQ WSLVMESVVPSDRG YTC+VEN GSIR Y L
Sbjct: 180 PTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLL 239
Query: 244 DVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT 303
DVLERSPHRPILQAGLPAN TAV+GSDVE CKVYSDAQPHIQWLKH+ +NGS G DG
Sbjct: 240 DVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGF 299
Query: 304 PYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEEL 363
PYV VLKTA N++ E+EVL L NV+ EDAGEYTCLAGNSIG S+ SAWL VLP E+
Sbjct: 300 PYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPT 357
Query: 364 VEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSP-TVHKISRFPLKRQ 422
A + Y I+ Y G +++ L R ++ + P TV K+SRFPL RQ
Sbjct: 358 WTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQ 417
Query: 423 VSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGC 482
SLES +S S++ LVR RLSS LA + L+LP DP WE R RL LGKPLGEGC
Sbjct: 418 FSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGC 477
Query: 483 FGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLL 542
FGQVV AEA G+D R + TVAVKMLKD+A+DKDL+DLVSEME+MK+IG+HKNIINLL
Sbjct: 478 FGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLL 537
Query: 543 GACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVA 602
G CTQ GPLYV+VE AAKGNLREFLRARRPPG D S D + E L+F LVSCAYQVA
Sbjct: 538 GVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVA 597
Query: 603 RGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMA 662
RGM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR VH++DYYKKT+NGRLPVKWMA
Sbjct: 598 RGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMA 657
Query: 663 PEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHD 722
PEALFDRVYTHQSDVWSFG+LLWEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C +
Sbjct: 658 PEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPE 717
Query: 723 LYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSS 782
LY +MRECWHAAPSQRPTFKQLVE LD+VL S +EYLDL F YSP G D SS+
Sbjct: 718 LYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVS-EEYLDLRLTFGPYSPSGGDA-SSTC 775
Query: 783 SGDDSVFAHDLLP 795
S DSVF+HD LP
Sbjct: 776 SSSDSVFSHDPLP 788
>gi|13186249 fibroblast growth factor receptor 1 isoform 9 precursor
[Homo sapiens]
Length = 785
Score = 918 bits (2372), Expect = 0.0
Identities = 473/776 (60%), Positives = 569/776 (73%), Gaps = 56/776 (7%)
Query: 39 PGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLN 98
P P + E + GD ++L C + W++DG L S R + + ++V +
Sbjct: 33 PWGAPVEVESFLVHPGDLLQLRCRLRDD--VQSINWLRDGVQLAESNRTRITGEEVEVQD 90
Query: 99 ASHEDSGAYSC-RQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG-------- 149
+ DSG Y+C + +FSV V+DA S +D+D +D++ +T
Sbjct: 91 SVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMP 150
Query: 150 -APYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRH 208
APYWT PE+M+KKL AVPAA TV+F+CP++G P P++ WLKNG+EF+ +HRIGG K+R+
Sbjct: 151 VAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRY 210
Query: 209 QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLG 268
WS++M+SVVPSD+GNYTC+VEN++GSI TY LDV+ERSPHRPILQAGLPAN+T LG
Sbjct: 211 ATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALG 270
Query: 269 SDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHN 328
S+VEF CKVYSD QPHIQWLKH+EVNGSK+GPD PYV +LKTAG NTTDKE+EVL L N
Sbjct: 271 SNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRN 330
Query: 329 VTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFIL 388
V+FEDAGEYTCLAGNSIG SHHSAWL VL A EE A +Y I+ Y G FL
Sbjct: 331 VSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEER-PAVMTSPLYLEIIIYCTGAFLISC 389
Query: 389 VVAAVTLCRLRSPPKKG--LGSPTVHKISR-FPLKRQV--SLESNASMSSNTPLVRIARL 443
+V +V + +++S KK VHK+++ PL+RQV S +S+ASM+S LVR +RL
Sbjct: 390 MVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRL 449
Query: 444 SSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPV 503
SS P LA VSE ELP DP+WEL R RL LGKPLGEGCFGQVV+AEAIG+DKD+ +
Sbjct: 450 SSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT 509
Query: 504 TVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNL 563
VAVKMLK DAT+KDLSDL+SEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGNL
Sbjct: 510 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 569
Query: 564 REFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNV 623
RE+L+ARRPPGL+Y ++ PEEQL+ KDLVSCAYQVARGMEYLAS+KCIHRDLAARNV
Sbjct: 570 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 629
Query: 624 LVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 683
LVTEDNVMKIADFGLARD+H++DYYKKTTNGRLPVKWMAPEALFDR+YTHQSDVWSFGVL
Sbjct: 630 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVL 689
Query: 684 LWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQ 743
LWEIFTLGGSPYPG+PVEEL FKQ
Sbjct: 690 LWEIFTLGGSPYPGVPVEEL-------------------------------------FKQ 712
Query: 744 LVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSS-SSGDDSVFAHDLLPPAP 798
LVEDLDR++ +TS EYLDLS P +QYSP DT SS+ SSG+DSVF+H+ LP P
Sbjct: 713 LVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEP 768
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 885 bits (2288), Expect = 0.0
Identities = 482/792 (60%), Positives = 552/792 (69%), Gaps = 52/792 (6%)
Query: 8 LALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGG 67
LAL + V G SL + V P E Q+++L G V L C G
Sbjct: 5 LALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQ-QEQELTVALGQPVRLCCGRAERG 63
Query: 68 PMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTD 127
W K+G+ L P+ RV RL++ + ED+G Y C R + VL + ++ D
Sbjct: 64 GH----WYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGD 119
Query: 128 A-PSSGDDEDGE---DEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPT 183
+ SS DDED + D + APYWT P+RM+KKL AVPA NTV+FRCPAAGNPT
Sbjct: 120 SLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPT 179
Query: 184 PSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTL 243
P+I WLK+G+ F GE+RIGGI+LRHQ WSLVMESVVPSDRG YTC+VEN GSIR Y L
Sbjct: 180 PTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLL 239
Query: 244 DVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT 303
DVLERSPHRPILQAGLPAN TAV+GSDVE CKVYSDAQPHIQWLKH+ +NGS G DG
Sbjct: 240 DVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGF 299
Query: 304 PYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEEL 363
PYV VLKTA N++ E+EVL L NV+ EDAGEYTCLAGNSIG S+ SAWL VLP
Sbjct: 300 PYVQVLKTADINSS--EVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLP----- 352
Query: 364 VEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQV 423
G G + + R +SP Q
Sbjct: 353 ----------------GTGRIPHLTCDSLTPAGRTKSPTL------------------QF 378
Query: 424 SLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCF 483
SLES +S S++ LVR RLSS LA + L+LP DP WE R RL LGKPLGEGCF
Sbjct: 379 SLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCF 438
Query: 484 GQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLG 543
GQVV AEA G+D R + TVAVKMLKD+A+DKDL+DLVSEME+MK+IG+HKNIINLLG
Sbjct: 439 GQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLG 498
Query: 544 ACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVAR 603
CTQ GPLYV+VE AAKGNLREFLRARRPPG D S D + E L+F LVSCAYQVAR
Sbjct: 499 VCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVAR 558
Query: 604 GMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAP 663
GM+YL S+KCIHRDLAARNVLVTEDNVMKIADFGLAR VH++DYYKKT+NGRLPVKWMAP
Sbjct: 559 GMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAP 618
Query: 664 EALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDL 723
EALFDRVYTHQSDVWSFG+LLWEIFTLGGSPYPGIPVEELF LL+EGHRMD+P +C +L
Sbjct: 619 EALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPEL 678
Query: 724 YMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSS 783
Y +MRECWHAAPSQRPTFKQLVE LD+VL S +EYLDL F YSP G D SS+ S
Sbjct: 679 YGLMRECWHAAPSQRPTFKQLVEALDKVLLAVS-EEYLDLRLTFGPYSPSGGDA-SSTCS 736
Query: 784 GDDSVFAHDLLP 795
DSVF+HD LP
Sbjct: 737 SSDSVFSHDPLP 748
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 790 bits (2039), Expect = 0.0
Identities = 416/543 (76%), Positives = 439/543 (80%), Gaps = 27/543 (4%)
Query: 271 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVT 330
V F C + P I WLK+ G + + G ++ ++ + +V
Sbjct: 172 VRFRCPAAGNPTPSISWLKN-----------GREFRGEHRIGGIKLRHQQWSLV-MESVV 219
Query: 331 FEDAGEYTCLAGNSIGFSHHSAWLVVL--PAEEELVEADEAGSVYAGILSYGVGFFLFIL 388
D G YTC+ N G + L VL +++A + A +L V F +
Sbjct: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTA-VLGSDVEFHCKVY 278
Query: 389 VVAAVTLCRLRSPPKKGL-----GSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARL 443
A + L+ G G+P V + +VSLESNASMSSNTPLVRIARL
Sbjct: 279 SDAQPHIQWLKHVEVNGSKVGPDGTPYVTVL-------KVSLESNASMSSNTPLVRIARL 331
Query: 444 SSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPV 503
SSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPV
Sbjct: 332 SSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPV 391
Query: 504 TVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNL 563
TVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNL
Sbjct: 392 TVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNL 451
Query: 564 REFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNV 623
REFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNV
Sbjct: 452 REFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNV 511
Query: 624 LVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 683
LVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL
Sbjct: 512 LVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 571
Query: 684 LWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQ 743
LWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQ
Sbjct: 572 LWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQ 631
Query: 744 LVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGG 803
LVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGG
Sbjct: 632 LVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGG 691
Query: 804 SRT 806
SRT
Sbjct: 692 SRT 694
Score = 640 bits (1650), Expect = 0.0
Identities = 310/312 (99%), Positives = 311/312 (99%)
Query: 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS 60
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS
Sbjct: 1 MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS 60
Query: 61 CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH 120
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH
Sbjct: 61 CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH 120
Query: 121 FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
Sbjct: 121 FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
Query: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
Sbjct: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
Query: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
Sbjct: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
Query: 301 DGTPYVTVLKTA 312
DGTPYVTVLK +
Sbjct: 301 DGTPYVTVLKVS 312
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 690 bits (1781), Expect = 0.0
Identities = 357/536 (66%), Positives = 416/536 (77%), Gaps = 23/536 (4%)
Query: 271 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVT 330
V+F C + P ++WLK+ G + + G ++ ++ + +V
Sbjct: 175 VKFRCPAGGNPMPTMRWLKN-----------GKEFKQEHRIGGYKVRNQHWSLI-MESVV 222
Query: 331 FEDAGEYTCLAGNSIGFSHHSAWL-VVLPAEEELVEADEAGSVYAGILSYGVGFFLFILV 389
D G YTC+ N G +H+ L VV P E+ + A Y I Y +G FL +
Sbjct: 223 PSDKGNYTCVVENEYGSINHTYHLDVVAPGREKEITASPD---YLEIAIYCIGVFLIACM 279
Query: 390 VAAVTLCRLRSPPKKG--LGSPTVHKIS-RFPLKRQV--SLESNASMSSNTPLVRIA-RL 443
V V LCR+++ KK P VHK++ R PL+RQV S ES++SM+SNTPLVRI RL
Sbjct: 280 VVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRL 339
Query: 444 SS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKP 502
SS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+ +
Sbjct: 340 SSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA 399
Query: 503 VTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGN 562
VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KGN
Sbjct: 400 VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 459
Query: 563 LREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARN 622
LRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLAARN
Sbjct: 460 LREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN 519
Query: 623 VLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 682
VLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV
Sbjct: 520 VLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 579
Query: 683 LLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFK 742
L+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRPTFK
Sbjct: 580 LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFK 639
Query: 743 QLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 798
QLVEDLDR+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D +P P
Sbjct: 640 QLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 695
Score = 212 bits (540), Expect = 1e-54
Identities = 109/207 (52%), Positives = 138/207 (66%), Gaps = 8/207 (3%)
Query: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Query: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
Query: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
Query: 220 PSDRGNYTCVVENKFGSIRQTYTLDVL 246
PSD+GNYTCVVEN++GSI TY LDV+
Sbjct: 223 PSDKGNYTCVVENEYGSINHTYHLDVV 249
>gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
Length = 705
Score = 647 bits (1668), Expect = 0.0
Identities = 339/537 (63%), Positives = 403/537 (75%), Gaps = 29/537 (5%)
Query: 271 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVT 330
V+F C + P ++WLK+ G + + G ++ ++ + +V
Sbjct: 175 VKFRCPAGGNPMPTMRWLKN-----------GKEFKQEHRIGGYKVRNQHWSLI-MESVV 222
Query: 331 FEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEE--LVEADEAGSVYAGILSYGVGFFLFIL 388
D G YTC+ N G +H+ L V+ +++A + + ++ V F +
Sbjct: 223 PSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANA-STVVGGDVEFVCKVY 281
Query: 389 VVAAVTLCRLRSPPKKGL-----GSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIA-R 442
A + ++ K G G P + + +VS ES++SM+SNTPLVRI R
Sbjct: 282 SDAQPHIQWIKHVEKNGSKYGPDGLPYLKVL-------KVSAESSSSMNSNTPLVRITTR 334
Query: 443 LSS-GEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAK 501
LSS + P LA VSE ELP DPKWE R +LTLGKPLGEGCFGQVVMAEA+GIDKD+ +
Sbjct: 335 LSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKE 394
Query: 502 PVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKG 561
VTVAVKMLKDDAT+KDLSDLVSEMEMMKMIGKHKNIINLLGACTQ GPLYV+VEYA+KG
Sbjct: 395 AVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG 454
Query: 562 NLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAAR 621
NLRE+LRARRPPG++YS+D + PEEQ+TFKDLVSC YQ+ARGMEYLASQKCIHRDLAAR
Sbjct: 455 NLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAAR 514
Query: 622 NVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFG 681
NVLVTE+NVMKIADFGLARD++N+DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFG
Sbjct: 515 NVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFG 574
Query: 682 VLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTF 741
VL+WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT++LYM+MR+CWHA PSQRPTF
Sbjct: 575 VLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTF 634
Query: 742 KQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP 798
KQLVEDLDR+LT+T+ +EYLDLS P EQYSP DT SS SSGDDSVF+ D +P P
Sbjct: 635 KQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEP 691
Score = 323 bits (829), Expect = 3e-88
Identities = 161/278 (57%), Positives = 198/278 (71%), Gaps = 8/278 (2%)
Query: 45 QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDS 104
Q E V G+++E+ C + W KDG L P+ R ++ + LQ+ A+ DS
Sbjct: 46 QPEVYVAAPGESLEVRCLLKDAAVIS---WTKDGVHLGPNNRTVLIGEYLQIKGATPRDS 102
Query: 105 GAYSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTG----APYWTRPERM 159
G Y+C R +F V VTDA SSGDDED D AED + APYWT E+M
Sbjct: 103 GLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKM 162
Query: 160 DKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVV 219
+K+L AVPAANTV+FRCPA GNP P++ WLKNG+EF+ EHRIGG K+R+Q WSL+MESVV
Sbjct: 163 EKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVV 222
Query: 220 PSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
PSD+GNYTCVVEN++GSI TY LDV+ERSPHRPILQAGLPAN + V+G DVEF CKVYS
Sbjct: 223 PSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYS 282
Query: 280 DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTT 317
DAQPHIQW+KHVE NGSK GPDG PY+ VLK + +++
Sbjct: 283 DAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKVSAESSS 320
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 328 bits (842), Expect = 9e-90
Identities = 224/622 (36%), Positives = 311/622 (50%), Gaps = 117/622 (18%)
Query: 222 DRGNYTCVVENKFGSIRQTYT--LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYS 279
D+G+Y C+ +++ R L VLER P + L NQT +G +E C
Sbjct: 636 DQGDYVCLAQDRKTKKRHCVVRQLTVLERVA--PTITGNLE-NQTTSIGESIEVSCTASG 692
Query: 280 DAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTC 339
+ P I W K E G VLK N L++ V ED G YTC
Sbjct: 693 NPPPQIMWFKDNETLVEDSG-------IVLKDGNRN--------LTIRRVRKEDEGLYTC 737
Query: 340 LAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLR 399
A + +G + A+ ++ A+E+ + + G + F+L ++++ LR
Sbjct: 738 QACSVLGCAKVEAFFIIEGAQEK---TNLEIIILVGTAVIAMFFWLLLVII-------LR 787
Query: 400 SPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELEL 459
+ + G +S ++ L+ + L
Sbjct: 788 TVKRANGGELKTGYLSIVMDPDELPLDEHCE---------------------------RL 820
Query: 460 PADP-KWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKD 518
P D KWE R RL LGKPLG G FGQV+ A+A GIDK + TVAVKMLK+ AT +
Sbjct: 821 PYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCR--TVAVKMLKEGATHSE 878
Query: 519 LSDLVSEMEMMKMIGKHKNIINLLGACTQ-GGPLYVLVEYAAKGNLREFLRARRPP---- 573
L+SE++++ IG H N++NLLGACT+ GGPL V+VE+ GNL +LR++R
Sbjct: 879 HRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPY 938
Query: 574 ---------GLDY---------------------------------SFDTCKPPEEQ--- 588
G DY + + PE+
Sbjct: 939 KTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKD 998
Query: 589 -LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDY 647
LT + L+ ++QVA+GME+LAS+KCIHRDLAARN+L++E NV+KI DFGLARD++
Sbjct: 999 FLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPD 1058
Query: 648 YKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELF-KL 706
Y + + RLP+KWMAPE +FDRVYT QSDVWSFGVLLWEIF+LG SPYPG+ ++E F +
Sbjct: 1059 YVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRR 1118
Query: 707 LKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDE-----YL 761
LKEG RM P T ++Y M +CWH PSQRPTF +LVE L +L + + L
Sbjct: 1119 LKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVL 1178
Query: 762 DLSAPFEQYSPGGQDTPSSSSS 783
+S G P+S S
Sbjct: 1179 PISETLSMEEDSGLSLPTSPVS 1200
Score = 45.8 bits (107), Expect = 2e-04
Identities = 34/133 (25%), Positives = 53/133 (39%), Gaps = 7/133 (5%)
Query: 161 KKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVP 220
+ L+ VR G P P I W KNG H IK H L + V
Sbjct: 337 ESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHT---IKAGH---VLTIMEVSE 390
Query: 221 SDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSD 280
D GNYT ++ N +Q++ + ++ P + ++ + + G+ C VY+
Sbjct: 391 RDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAI 450
Query: 281 AQP-HIQWLKHVE 292
P HI W +E
Sbjct: 451 PPPHHIHWYWQLE 463
Score = 37.7 bits (86), Expect = 0.043
Identities = 33/135 (24%), Positives = 55/135 (40%), Gaps = 24/135 (17%)
Query: 94 LQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYW 153
+++ NAS +D G Y C + + H VR + T ++ AP
Sbjct: 627 MELKNASLQDQGDYVCLAQDRKTKKRHCVVR-----------------QLTVLERVAP-- 667
Query: 154 TRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSL 213
T ++ + ++ ++ C A+GNP P I W K+ + GI L+ +L
Sbjct: 668 TITGNLENQTTSI--GESIEVSCTASGNPPPQIMWFKDNETLVED---SGIVLKDGNRNL 722
Query: 214 VMESVVPSDRGNYTC 228
+ V D G YTC
Sbjct: 723 TIRRVRKEDEGLYTC 737
Score = 37.0 bits (84), Expect = 0.073
Identities = 38/154 (24%), Positives = 64/154 (41%), Gaps = 27/154 (17%)
Query: 212 SLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQ--AGLPANQTAVLGS 269
+L ++ V SD+G YTC + + + + + V E+ P + +G+ + A +G
Sbjct: 291 TLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEK----PFVAFGSGMESLVEATVGE 346
Query: 270 DVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNV 329
V K P I+W K+ G P + N T K VL++ V
Sbjct: 347 RVRIPAKYLGYPPPEIKWYKN-----------GIPLES-------NHTIKAGHVLTIMEV 388
Query: 330 TFEDAGEYTCLAGNSIG---FSHHSAWLVVLPAE 360
+ D G YT + N I SH + +V +P +
Sbjct: 389 SERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQ 422
Score = 37.0 bits (84), Expect = 0.073
Identities = 20/69 (28%), Positives = 32/69 (46%), Gaps = 3/69 (4%)
Query: 44 GQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLV--GPQRLQVLNASH 101
G E G+++E+SC G P +W KD LV +++ G + L +
Sbjct: 671 GNLENQTTSIGESIEVSCTA-SGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRK 729
Query: 102 EDSGAYSCR 110
ED G Y+C+
Sbjct: 730 EDEGLYTCQ 738
Score = 30.0 bits (66), Expect = 8.9
Identities = 16/48 (33%), Positives = 24/48 (50%)
Query: 309 LKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVV 356
LKT + K L L++ VT D G YTC A + + +S ++ V
Sbjct: 277 LKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRV 324
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 328 bits (840), Expect = 2e-89
Identities = 174/344 (50%), Positives = 226/344 (65%), Gaps = 23/344 (6%)
Query: 453 NVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKD 512
+V ++ DPKWE R L LGK LGEG FG+VV A A + K RA TVAVKMLK+
Sbjct: 705 SVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-KGRAGY-TTVAVKMLKE 762
Query: 513 DATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRP 572
+A+ +L DL+SE ++K + H ++I L GAC+Q GPL ++VEYA G+LR FLR R
Sbjct: 763 NASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK 821
Query: 573 PGLDY--------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVL 624
G Y S P E LT DL+S A+Q+++GM+YLA K +HRDLAARN+L
Sbjct: 822 VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNIL 881
Query: 625 VTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLL 684
V E MKI+DFGL+RDV+ D Y K + GR+PVKWMA E+LFD +YT QSDVWSFGVLL
Sbjct: 882 VAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLL 941
Query: 685 WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQL 744
WEI TLGG+PYPGIP E LF LLK GHRM++P NC+ ++Y +M +CW P +RP F +
Sbjct: 942 WEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI 1001
Query: 745 VEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSV 788
+DL++++ +YLDL+A TPS S DD +
Sbjct: 1002 SKDLEKMM--VKRRDYLDLAA----------STPSDSLIYDDGL 1033
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 328 bits (840), Expect = 2e-89
Identities = 174/344 (50%), Positives = 226/344 (65%), Gaps = 23/344 (6%)
Query: 453 NVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKD 512
+V ++ DPKWE R L LGK LGEG FG+VV A A + K RA TVAVKMLK+
Sbjct: 705 SVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-KGRAGY-TTVAVKMLKE 762
Query: 513 DATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRP 572
+A+ +L DL+SE ++K + H ++I L GAC+Q GPL ++VEYA G+LR FLR R
Sbjct: 763 NASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK 821
Query: 573 PGLDY--------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVL 624
G Y S P E LT DL+S A+Q+++GM+YLA K +HRDLAARN+L
Sbjct: 822 VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNIL 881
Query: 625 VTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLL 684
V E MKI+DFGL+RDV+ D Y K + GR+PVKWMA E+LFD +YT QSDVWSFGVLL
Sbjct: 882 VAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLL 941
Query: 685 WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQL 744
WEI TLGG+PYPGIP E LF LLK GHRM++P NC+ ++Y +M +CW P +RP F +
Sbjct: 942 WEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI 1001
Query: 745 VEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSV 788
+DL++++ +YLDL+A TPS S DD +
Sbjct: 1002 SKDLEKMM--VKRRDYLDLAA----------STPSDSLIYDDGL 1033
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
sapiens]
Length = 1338
Score = 311 bits (797), Expect = 2e-84
Identities = 217/626 (34%), Positives = 306/626 (48%), Gaps = 111/626 (17%)
Query: 212 SLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDV 271
+L + +V D G Y C N + ++ R P L L ++ T + S
Sbjct: 620 NLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNL-SDHTVAISSST 678
Query: 272 EFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTF 331
C +P I W K N K+ + ++ G++T L + VT
Sbjct: 679 TLDCHANGVPEPQITWFK----NNHKIQQEPG----IILGPGSST-------LFIERVTE 723
Query: 332 EDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVA 391
ED G Y C A N G SA+L V +D++ + V LF L++
Sbjct: 724 EDEGVYHCKATNQKGSVESSAYLTVQGT------SDKSNLELITLTCTCVAATLFWLLLT 777
Query: 392 AVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTL 451
+ K+ R +S T + I + E P
Sbjct: 778 LF-----------------IRKMKR------------SSSEIKTDYLSII-MDPDEVPLD 807
Query: 452 ANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLK 511
L A KWE +R RL LGK LG G FG+VV A A GI K + TVAVKMLK
Sbjct: 808 EQCERLPYDAS-KWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCR--TVAVKMLK 864
Query: 512 DDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QGGPLYVLVEYAAKGNLREFLRAR 570
+ AT + L++E++++ IG H N++NLLGACT QGGPL V+VEY GNL +L+++
Sbjct: 865 EGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSK 924
Query: 571 RP--------------------PGL------------------------DYSFDTCKPPE 586
R PGL D S + E
Sbjct: 925 RDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEE 984
Query: 587 -------EQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLA 639
E +T +DL+S ++QVARGME+L+S+KCIHRDLAARN+L++E+NV+KI DFGLA
Sbjct: 985 DSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLA 1044
Query: 640 RDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIP 699
RD++ Y + + RLP+KWMAPE++FD++Y+ +SDVWS+GVLLWEIF+LGGSPYPG+
Sbjct: 1045 RDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQ 1104
Query: 700 VEELF-KLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVT--- 755
++E F L+EG RM P T ++Y IM +CWH P +RP F +LVE L +L
Sbjct: 1105 MDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQ 1164
Query: 756 STDEYLDLSAPFEQYSPGGQDTPSSS 781
+Y+ ++A S TP+ S
Sbjct: 1165 DGKDYIPINAILTGNSGFTYSTPAFS 1190
Score = 54.7 bits (130), Expect = 3e-07
Identities = 45/152 (29%), Positives = 66/152 (43%), Gaps = 24/152 (15%)
Query: 94 LQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYW 153
L ++N S +DSG Y+CR R + E+ + E T D APY
Sbjct: 621 LTIMNVSLQDSGTYACRAR-----------------NVYTGEEILQKKEITIRDQEAPYL 663
Query: 154 TRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSL 213
R + +A+ ++ T+ C A G P P I+W KN + + E GI L +L
Sbjct: 664 LR--NLSDHTVAISSSTTL--DCHANGVPEPQITWFKNNHKIQQE---PGIILGPGSSTL 716
Query: 214 VMESVVPSDRGNYTCVVENKFGSIRQTYTLDV 245
+E V D G Y C N+ GS+ + L V
Sbjct: 717 FIERVTEEDEGVYHCKATNQKGSVESSAYLTV 748
Score = 43.5 bits (101), Expect = 8e-04
Identities = 34/141 (24%), Positives = 57/141 (40%), Gaps = 10/141 (7%)
Query: 154 TRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSL 213
T R + L V + R P+P + WLK+G + + + +SL
Sbjct: 335 TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEK----SARYLTRGYSL 390
Query: 214 VMESVVPSDRGNYTCVV----ENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGS 269
+++ V D GNYT ++ N F ++ T ++V + + + + P LGS
Sbjct: 391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAV--SSFPDPALYPLGS 448
Query: 270 DVEFHCKVYSDAQPHIQWLKH 290
C Y QP I+W H
Sbjct: 449 RQILTCTAYGIPQPTIKWFWH 469
Score = 36.6 bits (83), Expect = 0.095
Identities = 27/121 (22%), Positives = 52/121 (42%), Gaps = 12/121 (9%)
Query: 224 GNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQP 283
G Y C+ NK G++ + + + + + +P G D++ C V
Sbjct: 531 GIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTE-----GEDLKLSCTVNKFLYR 585
Query: 284 HIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEV-LSLHNVTFEDAGEYTCLAG 342
+ W+ VN + T + ++ K A T + + + L++ NV+ +D+G Y C A
Sbjct: 586 DVTWILLRTVN------NRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRAR 639
Query: 343 N 343
N
Sbjct: 640 N 640
>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 2 precursor [Homo sapiens]
Length = 972
Score = 287 bits (734), Expect = 3e-77
Identities = 158/378 (41%), Positives = 217/378 (57%), Gaps = 63/378 (16%)
Query: 448 GPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAV 507
G + +LP D KWE R RL+ GK LG G FG+VV A A G+ K AA +TVAV
Sbjct: 561 GNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAA--MTVAV 618
Query: 508 KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 567
KMLK A + L+SE++++ +G H NI+NLLGACT GGP V+ EY G+L FL
Sbjct: 619 KMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFL 678
Query: 568 RARRP--------------------------------------PGLDYSFDT-------- 581
R +R PG+ Y T
Sbjct: 679 RRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSV 738
Query: 582 --------------CKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE 627
+ E L +DL+S +YQVA+GM +LAS+ CIHRDLAARN+L+T
Sbjct: 739 RIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH 798
Query: 628 DNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEI 687
+ KI DFGLARD+ N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ LWE+
Sbjct: 799 GRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWEL 858
Query: 688 FTLGGSPYPGIPVE-ELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVE 746
F+LG SPYPG+PV+ + +K++KEG RM P + ++Y IM+ CW A P +RPTFKQ+V+
Sbjct: 859 FSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 918
Query: 747 DLDRVLTVTSTDEYLDLS 764
+++ ++ ++ Y +L+
Sbjct: 919 LIEKQISESTNHIYSNLA 936
Score = 30.8 bits (68), Expect = 5.2
Identities = 14/40 (35%), Positives = 23/40 (57%)
Query: 209 QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLER 248
+Q +L + S +D G + C N FGS T TL+V+++
Sbjct: 271 RQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDK 310
>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 1 precursor [Homo sapiens]
Length = 976
Score = 287 bits (734), Expect = 3e-77
Identities = 158/378 (41%), Positives = 217/378 (57%), Gaps = 63/378 (16%)
Query: 448 GPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAV 507
G + +LP D KWE R RL+ GK LG G FG+VV A A G+ K AA +TVAV
Sbjct: 565 GNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAA--MTVAV 622
Query: 508 KMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFL 567
KMLK A + L+SE++++ +G H NI+NLLGACT GGP V+ EY G+L FL
Sbjct: 623 KMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFL 682
Query: 568 RARRP--------------------------------------PGLDYSFDT-------- 581
R +R PG+ Y T
Sbjct: 683 RRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSV 742
Query: 582 --------------CKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE 627
+ E L +DL+S +YQVA+GM +LAS+ CIHRDLAARN+L+T
Sbjct: 743 RIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH 802
Query: 628 DNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEI 687
+ KI DFGLARD+ N Y N RLPVKWMAPE++F+ VYT +SDVWS+G+ LWE+
Sbjct: 803 GRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWEL 862
Query: 688 FTLGGSPYPGIPVE-ELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVE 746
F+LG SPYPG+PV+ + +K++KEG RM P + ++Y IM+ CW A P +RPTFKQ+V+
Sbjct: 863 FSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 922
Query: 747 DLDRVLTVTSTDEYLDLS 764
+++ ++ ++ Y +L+
Sbjct: 923 LIEKQISESTNHIYSNLA 940
Score = 30.8 bits (68), Expect = 5.2
Identities = 14/40 (35%), Positives = 23/40 (57%)
Query: 209 QQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLER 248
+Q +L + S +D G + C N FGS T TL+V+++
Sbjct: 271 RQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDK 310
>gi|13186241 fibroblast growth factor receptor 1 isoform 6 precursor
[Homo sapiens]
Length = 300
Score = 277 bits (709), Expect = 2e-74
Identities = 129/206 (62%), Positives = 161/206 (78%), Gaps = 11/206 (5%)
Query: 129 PSSGDDEDGED------EAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNP 182
PSS DD+D +D E ++T + APYWT PE+M+KKL AVPAA TV+F+CP++G P
Sbjct: 34 PSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTP 93
Query: 183 TPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYT 242
P++ WLKNG+EF+ +HRIGG K+R+ WS++M+SVVPSD+GNYTC+VEN++GSI TY
Sbjct: 94 NPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQ 153
Query: 243 LDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDG 302
LDV+ERSPHRPILQAGLPAN+T LGS+VEF CKVYSD QPHIQWLKH+EVNGSK+GPD
Sbjct: 154 LDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDN 213
Query: 303 TPYVTVLKTAGA-----NTTDKELEV 323
PYV +LK A +T KE V
Sbjct: 214 LPYVQILKVIMAPVFVGQSTGKETTV 239
Score = 32.0 bits (71), Expect = 2.4
Identities = 23/87 (26%), Positives = 36/87 (41%), Gaps = 12/87 (13%)
Query: 271 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVT 330
V+F C P ++WLK NG + PD + G ++ + +V
Sbjct: 83 VKFKCPSSGTPNPTLRWLK----NGKEFKPDH-------RIGGYKVRYATWSII-MDSVV 130
Query: 331 FEDAGEYTCLAGNSIGFSHHSAWLVVL 357
D G YTC+ N G +H+ L V+
Sbjct: 131 PSDKGNYTCIVENEYGSINHTYQLDVV 157
>gi|13186238 fibroblast growth factor receptor 1 isoform 5 precursor
[Homo sapiens]
Length = 302
Score = 273 bits (699), Expect = 4e-73
Identities = 129/208 (62%), Positives = 160/208 (76%), Gaps = 13/208 (6%)
Query: 129 PSSGDDEDGEDEA-EDTGVDTG-------APYWTRPERMDKKLLAVPAANTVRFRCPAAG 180
PSS DD+D +D + E+ D APYWT PE+M+KKL AVPAA TV+F+CP++G
Sbjct: 34 PSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSG 93
Query: 181 NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT 240
P P++ WLKNG+EF+ +HRIGG K+R+ WS++M+SVVPSD+GNYTC+VEN++GSI T
Sbjct: 94 TPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHT 153
Query: 241 YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP 300
Y LDV+ERSPHRPILQAGLPAN+T LGS+VEF CKVYSD QPHIQWLKH+EVNGSK+GP
Sbjct: 154 YQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGP 213
Query: 301 DGTPYVTVLKTAGA-----NTTDKELEV 323
D PYV +LK A +T KE V
Sbjct: 214 DNLPYVQILKVIMAPVFVGQSTGKETTV 241
Score = 32.0 bits (71), Expect = 2.4
Identities = 23/87 (26%), Positives = 36/87 (41%), Gaps = 12/87 (13%)
Query: 271 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVT 330
V+F C P ++WLK NG + PD + G ++ + +V
Sbjct: 85 VKFKCPSSGTPNPTLRWLK----NGKEFKPDH-------RIGGYKVRYATWSII-MDSVV 132
Query: 331 FEDAGEYTCLAGNSIGFSHHSAWLVVL 357
D G YTC+ N G +H+ L V+
Sbjct: 133 PSDKGNYTCIVENEYGSINHTYQLDVV 159
>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
Length = 1124
Score = 249 bits (637), Expect = 5e-66
Identities = 137/306 (44%), Positives = 195/306 (63%), Gaps = 11/306 (3%)
Query: 478 LGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 537
+GEG FGQV+ A I KD + A+K +K+ A+ D D E+E++ +G H N
Sbjct: 830 IGEGNFGQVLKAR---IKKDGLR--MDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPN 884
Query: 538 IINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSC 597
IINLLGAC G LY+ +EYA GNL +FLR R D +F L+ + L+
Sbjct: 885 IINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHF 944
Query: 598 AYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLP 657
A VARGM+YL+ ++ IHRDLAARN+LV E+ V KIADFGL+R + Y K T GRLP
Sbjct: 945 AADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR---GQEVYVKKTMGRLP 1001
Query: 658 VKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPA 717
V+WMA E+L VYT SDVWS+GVLLWEI +LGG+PY G+ EL++ L +G+R++KP
Sbjct: 1002 VRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPL 1061
Query: 718 NCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDT 777
NC ++Y +MR+CW P +RP+F Q++ L+R+L T Y++ + +E+++ G D
Sbjct: 1062 NCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKT--YVNTTL-YEKFTYAGIDC 1118
Query: 778 PSSSSS 783
+ ++
Sbjct: 1119 SAEEAA 1124
>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
domains 1 [Homo sapiens]
Length = 1138
Score = 249 bits (637), Expect = 5e-66
Identities = 150/349 (42%), Positives = 206/349 (59%), Gaps = 24/349 (6%)
Query: 440 IARLSSGEGPTLANVSELELPADP------KWELSRARLTLGKPLGEGCFGQVVMAEAIG 493
I + SSG TL +L +P +WE +T +GEG FGQV+ A
Sbjct: 808 ILQFSSG---TLTLTRRPKLQPEPLSYPVLEWE----DITFEDLIGEGNFGQVIRAM--- 857
Query: 494 IDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYV 553
I KD + A+KMLK+ A++ D D E+E++ +G H NIINLLGAC G LY+
Sbjct: 858 IKKD--GLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYI 915
Query: 554 LVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKC 613
+EYA GNL +FLR R D +F L+ + L+ A A GM+YL+ ++
Sbjct: 916 AIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQF 975
Query: 614 IHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTH 673
IHRDLAARNVLV E+ KIADFGL+R + Y K T GRLPV+WMA E+L VYT
Sbjct: 976 IHRDLAARNVLVGENLASKIADFGLSRGE---EVYVKKTMGRLPVRWMAIESLNYSVYTT 1032
Query: 674 QSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHA 733
+SDVWSFGVLLWEI +LGG+PY G+ EL++ L +G+RM++P NC ++Y +MR+CW
Sbjct: 1033 KSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRD 1092
Query: 734 APSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSS 782
P +RP F Q+ L R+L Y+++S FE ++ G D + +
Sbjct: 1093 RPYERPPFAQIALQLGRMLEARKA--YVNMSL-FENFTYAGIDATAEEA 1138
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,646,206
Number of Sequences: 37866
Number of extensions: 1853825
Number of successful extensions: 12107
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 701
Number of HSP's successfully gapped in prelim test: 370
Number of HSP's that attempted gapping in prelim test: 5824
Number of HSP's gapped (non-prelim): 3284
length of query: 806
length of database: 18,247,518
effective HSP length: 110
effective length of query: 696
effective length of database: 14,082,258
effective search space: 9801251568
effective search space used: 9801251568
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.