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Search of human proteins with 4503179
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503179 oral-facial-digital syndrome 1 [Homo sapiens]
(1012 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503179 oral-facial-digital syndrome 1 [Homo sapiens] 1954 0.0
gi|21735548 centrosomal protein 2 [Homo sapiens] 88 5e-17
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 85 4e-16
gi|221219020 NYD-SP11 protein [Homo sapiens] 84 5e-16
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 84 7e-16
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 84 9e-16
gi|55770834 centromere protein F [Homo sapiens] 80 7e-15
gi|71061468 centromere protein E [Homo sapiens] 78 5e-14
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 77 6e-14
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 77 6e-14
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 76 2e-13
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 75 2e-13
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 75 2e-13
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 75 4e-13
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 75 4e-13
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 75 4e-13
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 75 4e-13
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 75 4e-13
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 74 5e-13
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 74 5e-13
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 73 1e-12
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 73 1e-12
gi|156104908 myosin heavy chain 6 [Homo sapiens] 73 1e-12
gi|31982906 cingulin-like 1 [Homo sapiens] 73 2e-12
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 73 2e-12
gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens] 73 2e-12
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 72 2e-12
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 72 3e-12
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 72 3e-12
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 71 4e-12
>gi|4503179 oral-facial-digital syndrome 1 [Homo sapiens]
Length = 1012
Score = 1954 bits (5062), Expect = 0.0
Identities = 1012/1012 (100%), Positives = 1012/1012 (100%)
Query: 1 MMAQSNMFTVADVLSQDELRKKLYQTFKDRGILDTLKTQLRNQLIHELMHPVLSGELQPR 60
MMAQSNMFTVADVLSQDELRKKLYQTFKDRGILDTLKTQLRNQLIHELMHPVLSGELQPR
Sbjct: 1 MMAQSNMFTVADVLSQDELRKKLYQTFKDRGILDTLKTQLRNQLIHELMHPVLSGELQPR 60
Query: 61 SISVEGSSLLIGASNSLVADHLQRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPT 120
SISVEGSSLLIGASNSLVADHLQRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPT
Sbjct: 61 SISVEGSSLLIGASNSLVADHLQRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPT 120
Query: 121 SSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLID 180
SSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLID
Sbjct: 121 SSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLID 180
Query: 181 DQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEK 240
DQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEK
Sbjct: 181 DQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEK 240
Query: 241 ELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGRE 300
ELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGRE
Sbjct: 241 ELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGRE 300
Query: 301 AELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDD 360
AELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDD
Sbjct: 301 AELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDD 360
Query: 361 YIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAI 420
YIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAI
Sbjct: 361 YIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAI 420
Query: 421 TKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELA 480
TKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELA
Sbjct: 421 TKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELA 480
Query: 481 VFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVA 540
VFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVA
Sbjct: 481 VFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVA 540
Query: 541 DLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVL 600
DLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVL
Sbjct: 541 DLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVL 600
Query: 601 ARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNS 660
ARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNS
Sbjct: 601 ARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNS 660
Query: 661 AKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGS 720
AKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGS
Sbjct: 661 AKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGS 720
Query: 721 AASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRH 780
AASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRH
Sbjct: 721 AASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRH 780
Query: 781 SLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEM 840
SLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEM
Sbjct: 781 SLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEM 840
Query: 841 GGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSN 900
GGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSN
Sbjct: 841 GGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSN 900
Query: 901 LQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEK 960
LQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEK
Sbjct: 901 LQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEK 960
Query: 961 YMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEELDDSW 1012
YMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEELDDSW
Sbjct: 961 YMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEELDDSW 1012
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 87.8 bits (216), Expect = 5e-17
Identities = 208/969 (21%), Positives = 386/969 (39%), Gaps = 147/969 (15%)
Query: 18 ELRKKLYQTFKDRGILDTLKTQLRNQL--IHELMHPVLS----GELQPRSISVEGSSLLI 71
+L+++L Q +++ + + L ++L +HE M + S ELQ E LL
Sbjct: 1289 DLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGE-RELLQ 1347
Query: 72 GASNSLVA--DHLQRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVS 129
A +L A +HLQ E +G+ +E + T + L+L K+
Sbjct: 1348 AAKENLTAQVEHLQAAVVEARAQA--SAAGILEEDLRTARSALKL----------KNEEV 1395
Query: 130 GSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRD--SLAEKLQLIDDQFADAY 187
S++E + ++A+ +E+ + TQT + + +L ++Q ++ Q +
Sbjct: 1396 ESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQ-REMQ 1454
Query: 188 PQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQN 247
++ SL++K KR E L+ E Q+L+ K + + A ++ E++LT+ +
Sbjct: 1455 KAALELLSLDLK----KRNQEVDLQQEQIQELE--KCRSVLEHLPMAVQEREQKLTVQRE 1508
Query: 248 DFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRV 307
+ + + + E LE K Q IE++ Q Q L K + L EL++
Sbjct: 1509 QIRELEKDRETQRNVLEHQLLELEKKDQMIESQR--GQVQDLKKQLVTLECLALELEENH 1566
Query: 308 EAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNR 367
E QKL +E +R+ Q + T D + +++ L+ Q D +
Sbjct: 1567 HKMECQQKLIKELEG------QRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTV 1620
Query: 368 LIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRV-KELELELESVKAQSLAITKQNHM 426
L + ++ ++ +E++ + +KE L Q + R +EL L+ E ++ T+Q +
Sbjct: 1621 LARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKI 1680
Query: 427 LNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKEL 486
L E ++++ L+E EL Q +L++++ EE + + L + L
Sbjct: 1681 LEEDLEQIK--LSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEH-------MKLIL 1731
Query: 487 RKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQ-VADLKLQ 545
R EK + + E ++ L+D++E Q + +G + + S Q + L+ Q
Sbjct: 1732 RDKEKEVECQQEHIHELQE-----LKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQ 1786
Query: 546 LKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVA 605
L++ + + E+ QS +D + L D +QE A+
Sbjct: 1787 LQEARE--QGELKEQSLQSQLDEAQRALAQR-----------DQELEALQQEQQQAQGQE 1833
Query: 606 SRITNYPTAWVEGSSPDSDLEFVANTKARVKELQ---QEAERLEKAFRSYHRRV-IKNSA 661
R+ A ++G+ + + K R ELQ ++A RLE+ RRV
Sbjct: 1834 ERVKEKADA-LQGALEQAHMTL----KERHGELQDHKEQARRLEEELAVEGRRVQALEEV 1888
Query: 662 KSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQ--PQVGTLEERNDVVEALTG 719
L A+S L A + + + H E R + + L+ER+ +EAL
Sbjct: 1889 LGDLRAESREQEKALLALQQQCAEQAQEHEV-ETRALQDSWLQAQAVLKERDQELEALRA 1947
Query: 720 SAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESR 779
+ S ++R +E E LG++H A + +
Sbjct: 1948 ESQSSRHQEEAARA-------------RAEALQEALGKAHAALQG------------KEQ 1982
Query: 780 HSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLE 839
H L Q EL E S ++S ++ RQLE
Sbjct: 1983 HLLE-----------------QAELSRSLEASTAT---------LQASLDACQAHSRQLE 2016
Query: 840 MGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKER--------R 891
G++ D L YQ +Q Q++EE +R QQ +E+ R
Sbjct: 2017 EALRIQEGEIQDQD-------LRYQEDVQQLQQALAQRDEE-LRHQQEREQLLEKSLAQR 2068
Query: 892 QREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKS 951
+E Q ERE E+ L+Q + ++ +L K ++ LE+ + +N E S
Sbjct: 2069 VQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHS 2128
Query: 952 AHSENPLEK 960
H +P+E+
Sbjct: 2129 -HKTSPMEE 2136
Score = 76.6 bits (187), Expect = 1e-13
Identities = 169/828 (20%), Positives = 338/828 (40%), Gaps = 130/828 (15%)
Query: 154 KESCNMETQTSSTFNRD--SLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQL 211
+E+ N+ Q + + +L ++LQ + + Q + + E+ +RE+ ++
Sbjct: 413 QEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQG-EVDSLSKERELLQKA 471
Query: 212 RAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERI 271
R E+ Q+L+ + E +++ + E +L +K Q + L +RE+ L+ +
Sbjct: 472 REELRQQLEVLEQ-EAWRLR---RVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEM 527
Query: 272 HKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQ 331
+E K+ + +L+ L++ +E+ L +L ++ +T AL R
Sbjct: 528 L--MGLEAKQSESLSELIT------------LREALESSHLEGELLRQEQTEVTAALARA 573
Query: 332 EQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINS 391
EQ+I + + LK E+ + + L D+ ++ + L+EE ++ S
Sbjct: 574 EQSIAELSSS-ENTLKTEVADLRAAAVKLSALN-EALALDKVGLNQQLLQLEEENQSVCS 631
Query: 392 KKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSL-LKEEKLELLAQ 450
+ E Q+ N L+++L + + A+ ++N L ++++ + L+ + ++ +
Sbjct: 632 RMEAAEQARNA---LQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEE 688
Query: 451 NKLLKQQLEESRNENLRLLNRLAQPAPEL---------AVFQKELRKAEKAIV-VEHEEF 500
+ ++++L ESR++ +L Q E AV +KE EKA + V +
Sbjct: 689 KEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAV 748
Query: 501 ESCRQALHKQLQD-----EIEHSAQLKAQILGYKASVKSLTTQVADLKLQ-LKQTQTALE 554
E RQ L +QLQ E+ S+ +AQ + SV +T ++++Q + Q + ++
Sbjct: 749 ERDRQDLAEQLQGLSSAKELLESSLFEAQ---QQNSVIEVTKGQLEVQIQTVTQAKEVIQ 805
Query: 555 NEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTA 614
EV C + +RS ++ + AR +A TA
Sbjct: 806 GEVRCLKLELDTERS----------------------QAEQERDAAARQLAQAEQEGKTA 843
Query: 615 WVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLH 674
+ + A KE+ Q E+ EK RS+H++ + + +S K +
Sbjct: 844 LEQQKA------------AHEKEVNQLREKWEKE-RSWHQQELAKALESLEREKMELEMR 890
Query: 675 LLEAFKNITSSSPERHIFGEDRVVSE----QPQVGTLEERNDVVEAL---------TGSA 721
L E + + +R E+R +E Q Q+ T +ER ++E L
Sbjct: 891 LKEQQTEMEAIQAQRE---EERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQ 947
Query: 722 ASRLRGGTSSRRLSS--------TPLPKAKRSLE--SEMYLEGLGRSHIASPSPCPDRMP 771
RLR ++L T L +A+R L+ + + + L S S D+M
Sbjct: 948 LERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMD 1007
Query: 772 LPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDK----------LAFKDN 821
L E L V+ Q++ Q +L++ E++ + K L+ +
Sbjct: 1008 LQKQVED---LKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEK 1064
Query: 822 EEFESSFESAGNMPRQLEMGGL-----SPAGDMSHVDAAAAAVPLSYQHPSVD----QKQ 872
E+ + A ++ RQ E+ L G+ + A + + D + Q
Sbjct: 1065 EQRLLVLQEADSI-RQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQ 1123
Query: 873 IEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERK 920
+ E+ E I EQQ++ +E + + LQ L +LE L E++
Sbjct: 1124 LLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQ 1171
Score = 65.9 bits (159), Expect = 2e-10
Identities = 123/540 (22%), Positives = 220/540 (40%), Gaps = 95/540 (17%)
Query: 53 LSGELQPRSISVEGSSLLIGASNSLVADHLQRCGYEYSLSVFFPESGLAKEKVFTMQDLL 112
L GEL R E ++ L A S+ + E +L + A K+ + + L
Sbjct: 554 LEGELL-RQEQTEVTAALARAEQSIA----ELSSSENTLKTEVADLRAAAVKLSALNEAL 608
Query: 113 QLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSL 172
L K+ L + ++ENQ + QA+ + ++ + R++L
Sbjct: 609 ALDKVGLNQQLLQL-----EEENQS-----VCSRMEAAEQARNALQVDLAEAEK-RREAL 657
Query: 173 AEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKM 232
EK ++ Q A + ++ + E K EI+++L Q+ T++ ++
Sbjct: 658 WEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEA--ATTQLEQLHQ 715
Query: 233 EAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKD 292
EAK++ E +A Q K EALV REK+ LE + E + +++ Q Q L
Sbjct: 716 EAKRQEEV--------LARAVQEK-EALV-REKAALEVRLQAVERDRQDLAEQLQGLSSA 765
Query: 293 MDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLK 352
+LL E +Q+ E+ + E + +++T+A + ++ KL+ + +
Sbjct: 766 KELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCL------KLELDTER 819
Query: 353 YQLELKDDYIIRTNRLIEDERKN---------------------KEKAVHLQEELIAINS 391
Q E + D R E E K KE++ H QE A+ S
Sbjct: 820 SQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALES 879
Query: 392 KKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQN 451
+ E + R+KE + E+E+++AQ +EE+ + A++
Sbjct: 880 LEREKMELEMRLKEQQTEMEAIQAQR-----------------------EEERTQ--AES 914
Query: 452 KLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQL 511
L + QL E+ E + LL L Q ELA ++L + + + V+ + + L QL
Sbjct: 915 ALCQMQL-ETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQL 973
Query: 512 QD---EIEHSAQ--------LKAQILGYKASVKSLTTQVADLKLQL---KQTQTALENEV 557
Q+ E++ +A+ L+ + L QV DLK QL +Q +E EV
Sbjct: 974 QEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEV 1033
Score = 64.7 bits (156), Expect = 4e-10
Identities = 171/831 (20%), Positives = 330/831 (39%), Gaps = 126/831 (15%)
Query: 227 IAKIKMEAKKKYEKELTMFQ----NDFEKACQAKSEALVLREKSTLERIHKHQEIETKEI 282
+AK + K+ +E+ + Q D EKA + + V + L + K E K I
Sbjct: 250 LAKTQELEKEAHERSQELIQLKSQGDLEKA---ELQDRVTELSALLTQSQKQNEDYEKMI 306
Query: 283 YAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKH------KSITEALRRQEQNIK 336
A R+ + ++L EL + + L++ QEEK K IT+ + + NI
Sbjct: 307 KALRETV----EILETNHTELMEHEAS--LSRNAQEEKLSLQQVIKDITQVMVEEGDNIA 360
Query: 337 SFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVH-LQEELI----AINS 391
+ + + Q + +D T L+ + +AV L+++L A+N
Sbjct: 361 QGSGHENSLELDSSIFSQFDYQDADKALT--LVRSVLTRRRQAVQDLRQQLAGCQEAVNL 418
Query: 392 KKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMS-DYSLLKEEKLELLAQ 450
+++ +Q K L L+ + + + Q L +V +S + LL++ + EL Q
Sbjct: 419 LQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQ 478
Query: 451 NKLLKQQLEESRNEN--LRLLNRLAQPAPE-------LAVFQKELRKAEKAIVVEHEEFE 501
++L+Q+ R N L+L AQ E LAV ++E R E + +E ++ E
Sbjct: 479 LEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERE-RLQEMLMGLEAKQSE 537
Query: 502 SC------RQALH---------KQLQDEIEHS-AQLKAQILGYKASVKSLTTQVADLKLQ 545
S R+AL +Q Q E+ + A+ + I +S +L T+VADL+
Sbjct: 538 SLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAA 597
Query: 546 LKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVA 605
+ NE K +++ + L N C+ + + + N L +A
Sbjct: 598 AVKLSAL--NEALALDKVG-LNQQLLQLEEENQSVCSRMEAAE------QARNALQVDLA 648
Query: 606 SRITNYPTAWVEGSSPDSDL----EFVANTKARVKELQQEAERLEKAF-RSYHRRVIKNS 660
W + + ++ L E A +A ++++Q+E E ++K S H++ +
Sbjct: 649 EAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATT 708
Query: 661 AKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTG- 719
L ++ +L + E+ ++ E +R D+ E L G
Sbjct: 709 QLEQLHQEAKRQEEVL------ARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGL 762
Query: 720 -SAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTES 778
SA L + ++ + K LE ++ + I C + L TE
Sbjct: 763 SSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRC---LKLELDTER 819
Query: 779 RHSLSIPPVSSPPEQKVGLYRRQ---TELQDKSEFSDVDKLAFKDNEEFESSFESAGNMP 835
S EQ+ RQ E + K+ K+ + +E +
Sbjct: 820 ----------SQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWH 869
Query: 836 RQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQRE- 894
+Q + A A L + ++ + E+Q E E I+ Q+ +ER Q E
Sbjct: 870 QQ---------------ELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAES 914
Query: 895 ---------ERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELE----MENELE 941
E+ + +L E L + ++EL Q+ + + + +K++ KE E ++ +L+
Sbjct: 915 ALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQ 974
Query: 942 MSNQEIKDKSAHSENPL----EKYMKIIQQEQD--QESADKSSKKMVQEGS 986
+ +E+K+ + + L E+ ++Q + D ++ D S+ + Q+ S
Sbjct: 975 EAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDS 1025
Score = 62.0 bits (149), Expect = 3e-09
Identities = 183/942 (19%), Positives = 375/942 (39%), Gaps = 149/942 (15%)
Query: 121 SSLYKSLVSGSDKENQKGFL---MHFLKELAEYHQAKESC---NMETQTSSTFN-RDSLA 173
SSL+++ S E KG L + + + E Q + C ++T+ S RD+ A
Sbjct: 771 SSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAA 830
Query: 174 EKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKME 233
+L + + A Q+ E+ N+ + + E++ + K + E K+++E
Sbjct: 831 RQLAQAEQEGKTALEQQKAAHEKEV--NQLREKWEKERSWHQQELAKALESLEREKMELE 888
Query: 234 AKKKY---EKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEI-----ETKEIYAQ 285
+ K E E Q + E+ QA+S ++ ++ ER+ + + E + Q
Sbjct: 889 MRLKEQQTEMEAIQAQREEERT-QAESALCQMQLETEKERVSLLETLLQTQKELADASQQ 947
Query: 286 RQLLLKDMDLLRGREAELKQ--RVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYD 343
+ L +DM + + +E E + + E ++L+E + + QE++ ++ D
Sbjct: 948 LERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMD 1007
Query: 344 RKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVH----LQEELIAINSKKEELNQS 399
+ + E LK QL +DD + RL+E E + K + +Q+EL +K L S
Sbjct: 1008 LQKQVEDLKSQLVAQDD----SQRLVEQEVQEKLRETQEYNRIQKEL---EREKASLTLS 1060
Query: 400 VNRVKELEL---ELESVKAQSLAITKQNHMLNEKVKEMSDYSL--------LKEEKLELL 448
+ ++ L E +S++ Q L+ +Q+ + E E + S +KE++ + L
Sbjct: 1061 LMEKEQRLLVLQEADSIRQQELSALRQD--MQEAQGEQKELSAQMELLRQEVKEKEADFL 1118
Query: 449 AQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALH 508
AQ L ++LE S +L L + A Q LR E + +AL
Sbjct: 1119 AQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQL-----------EALA 1167
Query: 509 KQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDR 568
+ Q + AQ +AQ+ ++++ V + + +L + + P Q
Sbjct: 1168 AEQQP--GNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQ----- 1220
Query: 569 SVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITN-----YPTAWVEGSSPDS 623
NG + FK+ +L + A + + + W + D
Sbjct: 1221 --NG-----------------ARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDV 1261
Query: 624 DLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKSPLAAKSPPSL--HLLEAFKN 681
+ V + R+ + + E ++ + R++ +N + SL L+E +
Sbjct: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET 1321
Query: 682 ITS--------------SSPERHIF--GEDRVVS--EQPQVGTLEERNDVVEALTGSAAS 723
+ S + ER + ++ + + E Q +E R A G
Sbjct: 1322 MASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAA--GILEE 1379
Query: 724 RLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLS 783
LR S+ +L + + + E L+ G +A + + L + T +
Sbjct: 1380 DLRTARSALKLKNEEVESER---ERAQALQEQGELKVAQGKALQENLALLTQTLAEREEE 1436
Query: 784 IPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGL 843
+ + ++ +Q E+Q K+ + K N+E + E + +
Sbjct: 1437 VETLRGQIQE----LEKQREMQ-KAALELLSLDLKKRNQEVDLQQEQIQELEK------- 1484
Query: 844 SPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEE----QKEEEKIREQQVKERRQREERRQS 899
S ++ AV Q +V ++QI E ++ + + E Q+ E ++++ +S
Sbjct: 1485 ----CRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIES 1540
Query: 900 NLQEV--LERERRELEKLYQERKMIEESLKI--KIKKELEMENE------------LEMS 943
+V L+++ LE L E + ++ K+ KELE + E LE
Sbjct: 1541 QRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEER 1600
Query: 944 NQEIKDKSAHSENPLEKYMKIIQQE-QDQESADKSSKKMVQE 984
+QE++ +S+ + LE + ++ +E Q+++ KS ++ ++E
Sbjct: 1601 SQELQAQSSQIHD-LESHSTVLARELQERDQEVKSQREQIEE 1641
Score = 61.2 bits (147), Expect = 5e-09
Identities = 103/456 (22%), Positives = 197/456 (43%), Gaps = 41/456 (8%)
Query: 118 NPTSSLYKS--LVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEK 175
N SL+K L++ E L ++L + Q ++ + Q D+ AEK
Sbjct: 1221 NGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEK 1280
Query: 176 ------LQLIDDQFADAYPQRIKFE----SLE---IKLNEYKREIEEQLRAEMCQKLKFF 222
LQ + Q + ++ K+E SLE ++L+E ++ +LR Q+++
Sbjct: 1281 SQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQ 1340
Query: 223 KDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEI 282
+ E+ + AK+ ++ Q +A S A +L E R + E E
Sbjct: 1341 GERELLQA---AKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVES 1397
Query: 283 YAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETY 342
+R L++ L+ + + Q A L Q L E + + E LR Q Q ++ E
Sbjct: 1398 ERERAQALQEQGELKVAQGKALQENLAL-LTQTLAEREEE--VETLRGQIQELEKQREM- 1453
Query: 343 DRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNR 402
+K ELL L+ ++ + I++ K + HL +A+ ++++L +
Sbjct: 1454 -QKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLP---MAVQEREQKLTVQREQ 1509
Query: 403 VKELELELES----VKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQL 458
++ELE + E+ ++ Q L + K++ M+ + ++ D LK++ + L + L +L
Sbjct: 1510 IRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQD---LKKQLVTL----ECLALEL 1562
Query: 459 EESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHS 518
EE+ ++ + +L + EL ++ R A + ++ EE QA Q+ D HS
Sbjct: 1563 EENHHK-MECQQKLIK---ELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHS 1618
Query: 519 AQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALE 554
L ++ VKS Q+ +L+ Q + LE
Sbjct: 1619 TVLARELQERDQEVKSQREQIEELQRQKEHLTQDLE 1654
Score = 48.1 bits (113), Expect = 4e-05
Identities = 182/894 (20%), Positives = 357/894 (39%), Gaps = 151/894 (16%)
Query: 157 CNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFES---------------LEIKLN 201
C M+ +T R SL E L + ADA Q + L+ +L
Sbjct: 917 CQMQLETEK--ERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQ 974
Query: 202 EYKREIEEQLRAEMCQKLKFFKDTE-IAKIKMEAKKKYE--KELTMFQNDFEKACQAKSE 258
E +RE++E R +++ + + KM+ +K+ E K + Q+D ++ + + +
Sbjct: 975 EAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQ 1034
Query: 259 ALVLREKSTLERIHKHQEIETKEIYA------QRQLLLKDMDLLRGRE-AELKQRVEAFE 311
LRE RI K E E + QR L+L++ D +R +E + L+Q ++ +
Sbjct: 1035 EK-LRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQ 1093
Query: 312 LNQK--------LQEEKHKSITEALRRQEQNIKSFEETY--DRKLKNEL-------LKYQ 354
QK L++E + + L ++ Q ++ E ++ +++L+ L + Q
Sbjct: 1094 GEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ 1153
Query: 355 LELKDDYIIRTNRLIEDERKNKEKAVH--------LQEELIAINSKKEELNQSVNRVKEL 406
L L+ E + N+ +A LQ+ L ++ + EL+ + +
Sbjct: 1154 LRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSV 1213
Query: 407 -ELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEES-RNE 464
LE + A+SL K+ +L E +L K L Q+ QQ + R++
Sbjct: 1214 WGLEPDQNGARSLF--KRGPLLTALSAEAVASALHK------LHQDLWKTQQTRDVLRDQ 1265
Query: 465 NLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEE---FESCRQALHKQLQDEIEHSAQL 521
+L RL E + EL+ ++ + EE +E + +L +L + E A L
Sbjct: 1266 VQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASL 1325
Query: 522 KAQILGYKASVKSLTTQVADLKLQL-KQTQTALENEVYCNPKQSVIDRSVNGLINGNVVP 580
++++ +A ++ + Q LQ K+ TA + ++ S G++ ++
Sbjct: 1326 QSRLR--RAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRT 1383
Query: 581 CNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQ 640
+ N + E A+ + + +G + +L + T A E ++
Sbjct: 1384 ARSALK--LKNEEVESERERAQALQEQ---GELKVAQGKALQENLALLTQTLA---EREE 1435
Query: 641 EAERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSE 700
E E L R I+ K K+ L L+ K V +
Sbjct: 1436 EVETL--------RGQIQELEKQREMQKAALELLSLDLKKR------------NQEVDLQ 1475
Query: 701 QPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHI 760
Q Q+ LE+ V+E L + R + T R + R LE + + H
Sbjct: 1476 QEQIQELEKCRSVLEHLPMAVQEREQKLTVQR--------EQIRELEKDRETQRNVLEHQ 1527
Query: 761 ASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKD 820
D+M ES+ V +Q V L EL++ + + K+
Sbjct: 1528 LLELEKKDQM-----IESQRG----QVQDLKKQLVTLECLALELEENHHKMECQQKLIKE 1578
Query: 821 NE-EFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEE 879
E + E+ + ++ LE + A ++ + H +V ++++E
Sbjct: 1579 LEGQRETQRVALTHLTLDLEERS-------QELQAQSSQIHDLESHSTVLARELQE---- 1627
Query: 880 EKIREQQVKERRQREE---RRQSNLQEVLERERREL-----------EKLYQERKMIEES 925
R+Q+VK +R++ E R++ +L + LER +EL ++ ++ K++EE
Sbjct: 1628 ---RDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEED 1684
Query: 926 LKIKIKKEL-EMENELEMSNQEIKDKSAHSENPLE------KYMKIIQQEQDQE 972
L+ +IK L E EL Q +++++ + P + ++MK+I +++++E
Sbjct: 1685 LE-QIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKE 1737
Score = 43.5 bits (101), Expect = 0.001
Identities = 149/849 (17%), Positives = 333/849 (39%), Gaps = 108/849 (12%)
Query: 191 IKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFE 250
+K +SL++ L E +++Q+ + K+++ A+ + + ++L +
Sbjct: 11 MKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQ---QRQATLVRKLQAKVLQYR 67
Query: 251 KACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAF 310
CQ + L +R +E E+ + + + + L +L+ +E
Sbjct: 68 SWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKA 127
Query: 311 ELNQKLQEEKHKSIT-------EALRRQEQNIKSFEETYDRKLKNE------LLKYQLEL 357
++ K E + +T + L R+E + +E + LK E L + +
Sbjct: 128 DVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTF 187
Query: 358 KDDYIIRTNRLIEDERKNKEKAVHLQEELIA------INSKKEELNQSVNRVKELELELE 411
+ ++ + D + K + V L L+ + ++ E N S +L
Sbjct: 188 RRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLL 247
Query: 412 SVKAQSLAITKQNHMLNEKVKEM-SDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLN 470
+ A++ + K+ H ++++ ++ S L K E + + + L Q ++ + +++
Sbjct: 248 LLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIK 307
Query: 471 RLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKA 530
L + L EL + E ++ +E + Q + K + + AQ G++
Sbjct: 308 ALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHEN 367
Query: 531 SVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISG-DF 589
S++ ++ + Q L V +Q+V D + + C ++
Sbjct: 368 SLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQD------LRQQLAGCQEAVNLLQQ 421
Query: 590 LNNPFKQENVLARMVASRITNY------PTAWVEGSSPDSDLEFVANTKARVKELQQEAE 643
++ +++E R ++T T ++G E KAR +EL+Q+ E
Sbjct: 422 QHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAR-EELRQQLE 480
Query: 644 RLEK-AFRSYHRRV---IKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVS 699
LE+ A+R V ++ + + LHL + ER E +
Sbjct: 481 VLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHL---------AVRERERLQEMLMGL 531
Query: 700 EQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLS--STPLPKAKRSLESEMYLEGLGR 757
E Q +L E + EAL +S L G + + + L +A++S+ E +
Sbjct: 532 EAKQSESLSELITLREALE---SSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLK 588
Query: 758 SHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLA 817
+ +A ++ + +L++ KVGL ++ +L++
Sbjct: 589 TEVADLRAAAVKL-----SALNEALAL--------DKVGLNQQLLQLEE----------- 624
Query: 818 FKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQK 877
+N+ S E+A L++ D++ + A+ H ++ EE
Sbjct: 625 --ENQSVCSRMEAAEQARNALQV-------DLAEAEKRREALWEKNTHLEAQLQKAEEAG 675
Query: 878 EEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEME 937
E + + ++E ++ +++ S + E +LE+L+QE K EE L ++++ +
Sbjct: 676 AELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEAL- 734
Query: 938 NELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADK----SSKKMVQEGSLVDTLQS 993
+++K+A LE ++ +++++ Q+ A++ SS K + E SL + Q
Sbjct: 735 ---------VREKAA-----LEVRLQAVERDR-QDLAEQLQGLSSAKELLESSLFEAQQQ 779
Query: 994 SDKVESLTG 1002
+ +E G
Sbjct: 780 NSVIEVTKG 788
Score = 39.7 bits (91), Expect = 0.014
Identities = 31/156 (19%), Positives = 72/156 (46%), Gaps = 16/156 (10%)
Query: 873 IEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERR-------ELEKLYQERKMIEES 925
+ ++++E + +QQ++E R++ E ++ +LQ L+ +R ELE L QE++ +
Sbjct: 1773 LSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQ 1832
Query: 926 LKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQ---------QEQDQESADK 976
+ +K ++ LE ++ +K++ ++ E+ ++ + Q ++ D
Sbjct: 1833 EERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDL 1892
Query: 977 SSKKMVQEGSLVDTLQSSDKVESLTGFSHEELDDSW 1012
++ QE +L+ Q + L DSW
Sbjct: 1893 RAESREQEKALLALQQQCAEQAQEHEVETRALQDSW 1928
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 84.7 bits (208), Expect = 4e-16
Identities = 103/451 (22%), Positives = 191/451 (42%), Gaps = 87/451 (19%)
Query: 189 QRIKFESLEIKLNEYKR--EIEEQLRAEMCQKLKFFKDT----------EIAKIKMEA-- 234
+R FE LE L+ ++ E +L+AEM +++K + T E++++K E
Sbjct: 409 ERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVD 468
Query: 235 -------------KKKYEKELTMFQNDFEKACQAKSEAL-----VLREKSTLERIHKHQE 276
+K +EKEL + + K Q + V EKS E + QE
Sbjct: 469 VMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQE 528
Query: 277 IETKEIYAQRQLLLKDMDLLRGRE---AELKQRVEAFE---------LNQKLQEEKHKSI 324
E +E A +L L+ +L E +L+Q E + L + LQE K++S
Sbjct: 529 KEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSK 588
Query: 325 TEALRRQEQNIKSFEE----TYDRKLKNELLKYQLE---------LKDDYIIRTNRLIED 371
A+ + + K +E K + E LK+Q + LK Y +L
Sbjct: 589 DLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKL--R 646
Query: 372 ERKNKEKAVHLQEELIAINSKKEELNQ-SVNRVKELELELESVKAQSLAITKQNHMLNEK 430
E+ +EK L+++ I + EE+N+ ++ ++ + ELES+ ++ + K H L E+
Sbjct: 647 EKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEE 706
Query: 431 VKEMSDY------------------------SLLKEEKLELLAQNKLLKQQLEESRNENL 466
+ + D S++KE ++ + K LK Q+ +
Sbjct: 707 LSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLK 766
Query: 467 RLLNRLAQPAPELAVFQKELRKAEKAIV---VEHEEFESCRQALHKQLQDEIEHSAQLKA 523
L + + + +++++E + + + F+S + A H+Q + E AQL+
Sbjct: 767 ERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQ 826
Query: 524 QILGYKASVKSLTTQVADLKLQLKQTQTALE 554
++L + LT QVA+++ Q K T L+
Sbjct: 827 KLLDLETERILLTKQVAEVEAQKKDVCTELD 857
Score = 74.3 bits (181), Expect = 5e-13
Identities = 196/1028 (19%), Positives = 408/1028 (39%), Gaps = 176/1028 (17%)
Query: 108 MQDLLQLI---------KINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCN 158
+QDL+Q + K+ + +Y+S + +KE ++ L E KE+
Sbjct: 863 VQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQ--TKQILVE-------KENMI 913
Query: 159 METQTSSTFNRDSLAEKLQLIDDQFADAYPQ-RIKFESLEIKLNEYK---REIEEQLRAE 214
++ + + L +KL +D + KF++ E K+ + K +E++E L+ +
Sbjct: 914 LQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKK 973
Query: 215 MC-QKLKFFKDTEIAKIKMEAKKKY--EKELTMFQNDFEKACQAKSEALVLREKSTLERI 271
+ Q+ K K+ E +++ K+K K L M Q + A S L +K +E +
Sbjct: 974 LLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSR-LETNQKEQIESL 1032
Query: 272 HKHQEIETKEIYA--QRQLLLKDMDLLRGREAELKQRV-EAFELNQKL------QEEKHK 322
+ E ++ + +++L + +L E +L+++ E EL QK+ +EE +K
Sbjct: 1033 TEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNK 1092
Query: 323 SIT-----------------EALRRQEQNIKSFEETYDRKLKNELLKYQLELK------- 358
IT E L+++ ++ S + + KLK L K +++L
Sbjct: 1093 EITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQD-ETKLKAHLEKLEVDLNKSLKENT 1151
Query: 359 --DDYIIRTNRLIE-DERKNKEKAVHLQ---EELIAINSKKEELNQSVN-------RVKE 405
+ ++ L E D+RK E L+ EE ++ S E+ N+S+ ++ E
Sbjct: 1152 FLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE 1211
Query: 406 ---LELELESVKAQSLAITKQNHMLN--------------------EKVKEM-------- 434
++L++ K ++L K N ++N KVKE
Sbjct: 1212 ELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTV 1271
Query: 435 ----SDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAE 490
+ L EE+ L + QLEE N+ + + E QKE +
Sbjct: 1272 SELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQ 1331
Query: 491 KAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQ 550
+A E ESC L K+L + I +K ++ K + SL+ Q+ DL +QL+ +
Sbjct: 1332 QAA----SEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSI 1387
Query: 551 TALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISG-DFLNNPFKQENVLARMVASRIT 609
+ E E + + D L++ ++ F + +E + A +
Sbjct: 1388 SLSEKEAAISSLRKQYDEEKCELLD--------QVQDLSFKVDTLSKEKISALEQVDDWS 1439
Query: 610 NYPTAW--------VEGSSPDSDLEFVANTKAR--------VKELQQEAERLEKAFRSYH 653
N + W + + +L+ K++ + L++E ++ K F
Sbjct: 1440 NKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLK 1499
Query: 654 RRVIKNSAK-----SPLAAK-SPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTL 707
+ + +K S L + + ++E +IT + E E V+ Q +
Sbjct: 1500 GEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNE--VLKNYNQQKDI 1557
Query: 708 EERNDV-----VEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIAS 762
E + V + L +R++ + K LE++ + L +++
Sbjct: 1558 EHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKK--KELEHVNLSV 1615
Query: 763 PSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQ--TELQDKSEFSDVDKLAFKD 820
S + L ES + + + EQK+ ++Q +++++K E +K
Sbjct: 1616 KSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEE-------QYKK 1668
Query: 821 NEEFESSFESAGNMPRQLEMGGL-SPAGDMSHVDAAAAAVPLSYQHPS--VDQKQIEEQK 877
E S + R+ E+ L + + VP S ++ + +Q++ + Q
Sbjct: 1669 GTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQG 1728
Query: 878 EEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIK----KE 933
+K E+++ ++ ++ LQ V + + + ++ R +E L IK++ K+
Sbjct: 1729 CVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERL-IKLEHAEAKQ 1787
Query: 934 LEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQS 993
E ++ + +E+++K+ +KY I+ Q ++E + + ++ D +Q
Sbjct: 1788 HEDQSMIGHLQEELEEKN-------KKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQK 1840
Query: 994 SDKVESLT 1001
+ + + LT
Sbjct: 1841 TLQEKELT 1848
Score = 68.9 bits (167), Expect = 2e-11
Identities = 101/442 (22%), Positives = 194/442 (43%), Gaps = 66/442 (14%)
Query: 193 FESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKA 252
F+S + +E + EEQL A++ QKL + I K A+ + +K+ + D K
Sbjct: 803 FQSYQSATHEQTKAYEEQL-AQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKI 861
Query: 253 ---------------CQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLR 297
+ K ++L +S LE +K QE +TK+I +++ ++ M +
Sbjct: 862 QVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE-QTKQILVEKENMILQMREGQ 920
Query: 298 GREAE-LKQRVEA-----------FELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRK 345
+E E L Q++ A +E K QE+K + + + + ++ +K + K
Sbjct: 921 KKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAK 980
Query: 346 LKNELLKYQLELKDDYIIRTNRLIEDERKN---------------KEK-----AVHLQEE 385
LK EL LEL +++E + N KE+ VH +E
Sbjct: 981 LKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRREL 1040
Query: 386 LIAINSKKEELNQSVNRVKEL-ELELESVKAQSLAITKQNHML--NEKVKEMSDYSLLKE 442
I+ +++LNQ ++E+ E++L+ K Q +A KQ +L EK + + + LKE
Sbjct: 1041 NDVISIWEKKLNQQAEELQEIHEIQLQE-KEQEVAELKQKILLFGCEKEEMNKEITWLKE 1099
Query: 443 EKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAV----FQKELRKAEKAIVVEHE 498
E ++ Q+ L +L+E + +N LAQ +L + +L K+ K E
Sbjct: 1100 EGVK---QDTTL-NELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQE 1155
Query: 499 EFESCRQALHKQLQDEIEHSAQLKA---QILGYKASVKSLTTQVADLKLQLKQ--TQTAL 553
+ + + + E +++LK + K+S + + D L+ K+ + A+
Sbjct: 1156 QLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAI 1215
Query: 554 ENEVYCNPKQSVIDRSVNGLIN 575
+ ++ C +++++ N LIN
Sbjct: 1216 QLDICCKKTEALLEAKTNELIN 1237
Score = 62.4 bits (150), Expect = 2e-09
Identities = 147/807 (18%), Positives = 319/807 (39%), Gaps = 101/807 (12%)
Query: 200 LNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEA 259
+ + K+E+ E + A K ++ + K+++ + K +L + Q ++
Sbjct: 1341 ITQLKKELSENINAVTLMK----EELKEKKVEISSLSKQLTDLNV---------QLQNSI 1387
Query: 260 LVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAF-----ELNQ 314
+ +++ + + K + E E+ Q Q L +D L + ++V+ + E +
Sbjct: 1388 SLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKK 1447
Query: 315 KLQEE--KHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDD-YIIRTNRLIED 371
K Q +H++ + L+ Q + +KS +E Y++ + LLK +L+ ++ + + +D
Sbjct: 1448 KAQSRFTQHQNTVKELQIQLE-LKS-KEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDD 1505
Query: 372 ERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLN-EK 430
+ K ++K +L+ EL + ++ EL + + + +E+ES+ +Q + + E
Sbjct: 1506 KSKMEKKESNLETELKSQTARIMELE---DHITQKTIEIESLNEVLKNYNQQKDIEHKEL 1562
Query: 431 VKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAE 490
V+++ + L EEK +++E+ + L L N++ EL +KEL
Sbjct: 1563 VQKLQHFQELGEEK----------DNRVKEAEEKILTLENQVYSMKAELETKKKELEHVN 1612
Query: 491 KAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQ 550
++ + EE K L+D +E + K L KA K +A +K QL +Q
Sbjct: 1613 LSVKSKEEEL--------KALEDRLESESAAKLAELKRKAEQK-----IAAIKKQLL-SQ 1658
Query: 551 TALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFK--QENVLARMVASRI 608
+ E Y +S + +N + E+ L K + + ++ R
Sbjct: 1659 MEEKEEQYKKGTESHLSE-----LNTKLQEREREVH--ILEEKLKSVESSQSETLIVPRS 1711
Query: 609 TNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKSPLAAK 668
A+ E DS + ++ LQ+ EK + + + +++
Sbjct: 1712 AKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQR-----VGQEKEETVSSH 1766
Query: 669 SPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVG----TLEERNDVVEALTGSAASR 724
E + + ++H +Q +G LEE+N + +
Sbjct: 1767 FEMRCQYQERLIKLEHAEAKQH--------EDQSMIGHLQEELEEKNKKYSLIVAQHVEK 1818
Query: 725 LRGGTS--SRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPC------PDRMPLPSPT 776
G + +++ +++L+ + + I C R+ + T
Sbjct: 1819 EGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELT 1878
Query: 777 ESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPR 836
L + L TE + KS L+ + + + F+ AG
Sbjct: 1879 SKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAERE 1938
Query: 837 QLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREER 896
+ ++G ++ + + +Q K+ +Q+ EEKI+++Q E +
Sbjct: 1939 KQKLGK-----EIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQ----EDLELK 1989
Query: 897 RQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQE----IKDKSA 952
S L++++ +L + QE +E ++K I K E+E EL S+QE + K A
Sbjct: 1990 HNSTLKQLMREFNTQLAQKEQE---LEMTIKETINKAQEVEAELLESHQEETNQLLKKIA 2046
Query: 953 HSENPLEKYMKIIQQEQDQESADKSSK 979
++ L++ K ++ D + ++K
Sbjct: 2047 EKDDDLKRTAKRYEEILDAREEEMTAK 2073
Score = 57.0 bits (136), Expect = 9e-08
Identities = 149/788 (18%), Positives = 317/788 (40%), Gaps = 91/788 (11%)
Query: 154 KESCNMETQTSS-TFNRDSLA-EKLQLID--DQFADAYPQRIKFESLEIKLNEYKREIEE 209
+E C + Q +F D+L+ EK+ ++ D +++ + + K + + +++ ++E
Sbjct: 1405 EEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKK--KAQSRFTQHQNTVKE 1462
Query: 210 -QLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKE--LTMFQNDFEKACQAKSEALVLREKS 266
Q++ E+ K + KD +I +K E ++ ++ L D + + K L KS
Sbjct: 1463 LQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKS 1522
Query: 267 TLERIHKHQEIETKEIYAQRQL--LLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSI 324
RI + ++ T++ L +LK+ + + ++ E K+ V+ + Q+L EEK +
Sbjct: 1523 QTARIMELEDHITQKTIEIESLNEVLKNYN--QQKDIEHKELVQKLQHFQELGEEKDNRV 1580
Query: 325 TEA------LRRQEQNIKSFEETYDRKLKNELLKY-----QLELKDDYIIRTN--RLIED 371
EA L Q ++K+ ET ++L++ L +L+ +D + + +L E
Sbjct: 1581 KEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAEL 1640
Query: 372 ERKNKEKAVHLQEELIAINSKKEE---------LNQSVNRVKELELELESVKAQSLAI-- 420
+RK ++K ++++L++ +KEE L++ +++E E E+ ++ + ++
Sbjct: 1641 KRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVES 1700
Query: 421 -TKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQ--QLEESRNENLRLLNRLAQPAP 477
+ ++ K ++ Y+ +E + Q ++ L+ + E +LL R+ Q
Sbjct: 1701 SQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKE 1760
Query: 478 EL--AVFQKELRKAEKAIVVEHEEFESCR-QALHKQLQDEIEHSAQLKAQILGY---KAS 531
E + F+ + E+ I +EH E + Q++ LQ+E+E + + I+ K
Sbjct: 1761 ETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEG 1820
Query: 532 VKSLTTQVADLKLQLKQTQTAL-ENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFL 590
K+ +L+ Q L E E+ C + I + L+ V + + L
Sbjct: 1821 GKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEV---HRVEMEEL 1877
Query: 591 NNPFKQENVLARMVASRITNYPTAWVEGSSPD-------------------SDLEF-VAN 630
+ +++ L +M N PT +E ++ + +DLEF +A
Sbjct: 1878 TSKYEKLQALQQMDG---RNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAG 1934
Query: 631 TKARVKELQQEAERLEKAFRSYHR------RVIKNSAKSPLAAKSPPSLHLLEAFKNITS 684
+ ++L +E RL+K R + ++K K LE N T
Sbjct: 1935 AEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTL 1994
Query: 685 SSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKR 744
R F EQ T++E + + + + T ++ L
Sbjct: 1995 KQLMRE-FNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEET-NQLLKKIAEKDDDL 2052
Query: 745 SLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTEL 804
++ Y E L + D + ++ + +P V + QT+L
Sbjct: 2053 KRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQL 2112
Query: 805 QDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLE-------MGGLSPAGDMSHVDAAAA 857
K+ KL +EF + + ++ E +G G++ H D +
Sbjct: 2113 AQKTTLISDSKL---KEQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGGNLYHTDVSLF 2169
Query: 858 AVPLSYQH 865
P +++
Sbjct: 2170 GEPTEFEY 2177
Score = 56.6 bits (135), Expect = 1e-07
Identities = 91/466 (19%), Positives = 204/466 (43%), Gaps = 54/466 (11%)
Query: 123 LYKSLVSGSDKENQKGFLMHFLKELAEYHQAKES----CNMET--QTSSTFNRDSLAEKL 176
L + L S +++ + K +A Y + +E+ C +T + S R+ L EK
Sbjct: 1691 LEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRN-LTEKE 1749
Query: 177 QLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQ---LRAEMCQKLKFFKDTEIAKIKME 233
+L+ QR+ E E + ++ + Q ++ E + + + I ++ E
Sbjct: 1750 KLL---------QRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEE 1800
Query: 234 AKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHK--HQEIETKEIYAQ-RQLLL 290
++K +K + EK + ++ K LE + + ++ KE+ Q + +
Sbjct: 1801 LEEKNKKYSLIVAQHVEKEGGKNN----IQAKQNLENVFDDVQKTLQEKELTCQILEQKI 1856
Query: 291 KDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKS---FEETYDRKLK 347
K++D R+ E+ RVE EL K ++ +AL++ + K EE + K K
Sbjct: 1857 KELDSCLVRQKEV-HRVEMEELTSKYEK------LQALQQMDGRNKPTELLEENTEEKSK 1909
Query: 348 NELLKYQL-----ELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNR 402
+ L++ +L +D + +++K ++ V LQ++L + + ++ + + +
Sbjct: 1910 SHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKK 1969
Query: 403 VKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQ----- 457
+ E E + + Q K N L + ++E + KE++LE+ + + K Q
Sbjct: 1970 EYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAE 2029
Query: 458 -LEESRNENLRLLNRLAQPAPEL----AVFQKELRKAEKAIVVEHEEFESCRQALHKQLQ 512
LE + E +LL ++A+ +L +++ L E+ + + + ++ + L K+ Q
Sbjct: 2030 LLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQ 2089
Query: 513 DEI---EHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALEN 555
++ E+ I+ + + TT ++D KL+ ++ + + N
Sbjct: 2090 QKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHN 2135
Score = 55.8 bits (133), Expect = 2e-07
Identities = 181/899 (20%), Positives = 356/899 (39%), Gaps = 179/899 (19%)
Query: 154 KESC--NMETQTSSTFN-----RDSLAEK---LQLIDDQFADAYPQ---RIKFESLEIKL 200
KESC ++ + S N ++ L EK + + Q D Q I E +
Sbjct: 1337 KESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAI 1396
Query: 201 NEYKREIEEQL--RAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSE 258
+ +++ +E+ + Q L F DT ++K K+ A ++ + + N F + + K++
Sbjct: 1397 SSLRKQYDEEKCELLDQVQDLSFKVDT-LSKEKISALEQVDD----WSNKFSE-WKKKAQ 1450
Query: 259 ALVLREKSTLERIHKHQEIETKEIYAQRQL--LLKD--------MDLLRGREAELKQRVE 308
+ + ++T++ + E+++KE Y + + LLK+ D L+G + K ++E
Sbjct: 1451 SRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKME 1510
Query: 309 AFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRL 368
E N E + KS T + E +I ++T + + NE+LK + KD I L
Sbjct: 1511 KKESNL---ETELKSQTARIMELEDHIT--QKTIEIESLNEVLKNYNQQKD---IEHKEL 1562
Query: 369 IEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLN 428
++ K H QE + +K+ NRVKE E ++ +++ Q ++ + L
Sbjct: 1563 VQ-------KLQHFQE----LGEEKD------NRVKEAEEKILTLENQVYSMKAE---LE 1602
Query: 429 EKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRK 488
K KE+ +L + K E L K L+ +LE ++ A +LA + RK
Sbjct: 1603 TKKKELEHVNLSVKSKEEEL---KALEDRLE-------------SESAAKLAELK---RK 1643
Query: 489 AEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQ 548
AE+ I A+ KQL ++E + + G ++ + L T++ + + ++
Sbjct: 1644 AEQKIA-----------AIKKQLLSQMEEKEEQYKK--GTESHLSELNTKLQEREREVHI 1690
Query: 549 TQTALENEVYCNPKQSVIDRSVNGLI----------NGNVVPCNGEISGDFLNNPFKQEN 598
+ L++ + ++ RS + G V E N ++E
Sbjct: 1691 LEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEK 1750
Query: 599 VLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKE-------LQQEAERLEKAFRS 651
+L R+ + + + L + + +A+ E LQ+E E K +
Sbjct: 1751 LLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSL 1810
Query: 652 Y-HRRVIKNSAKSPLAAKSPPSLHLLEAF---------KNITSSSPERHIFGEDRVVSEQ 701
+ V K K+ + AK +L F K +T E+ I D + Q
Sbjct: 1811 IVAQHVEKEGGKNNIQAKQ----NLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQ 1866
Query: 702 PQVGTLE--------ERNDVVEALTG--SAASRLRGGTSSRRLSSTPLPKAKRSLES--- 748
+V +E E+ ++ + G L T + S PK ++E+
Sbjct: 1867 KEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHN 1926
Query: 749 --EMYLEG-------LGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYR 799
E L G LG+ + D L + + E+K+ +
Sbjct: 1927 DLEFKLAGAEREKQKLGKEIVRLQK---DLRMLRKEHQQELEILKKEYDQEREEKIKQEQ 1983
Query: 800 RQTELQDKSEFSDV-----DKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDA 854
EL+ S + +LA K+ +E E + + N +++E L SH +
Sbjct: 1984 EDLELKHNSTLKQLMREFNTQLAQKE-QELEMTIKETINKAQEVEAELLE-----SHQEE 2037
Query: 855 AAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEK 914
+ K+I E+ ++ K ++ +E E + L+ + EL+K
Sbjct: 2038 TNQLL-----------KKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQK 2086
Query: 915 LYQERKMIEES----------LKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMK 963
YQ++ EE+ L+ ++ ++ + ++ ++ QE +++ + E+ L+KY K
Sbjct: 2087 KYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEK 2145
Score = 55.1 bits (131), Expect = 3e-07
Identities = 182/956 (19%), Positives = 376/956 (39%), Gaps = 147/956 (15%)
Query: 165 STFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKD 224
+TF ++ L E L ++ K ++ + + K E+ ++ + L+F K
Sbjct: 1150 NTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKL 1209
Query: 225 TEIAKIKME-AKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQE---IET- 279
+E I+++ KK E L N+ +K+ A++ R R K +E I+T
Sbjct: 1210 SEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTC 1269
Query: 280 --KEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSIT---EALRRQ--- 331
E+ AQ + L ++ + L + ++E E K + +S+ EAL+++
Sbjct: 1270 TVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGN 1329
Query: 332 EQNIKSFEETYDRKLKNEL---------LKYQLELKDDYIIRTNRLIEDERKNKEKAVHL 382
+Q S +E+ +LK EL +K +L+ K I ++ + D + ++ L
Sbjct: 1330 QQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISL 1389
Query: 383 QEELIAINSKKEELNQS----VNRVKELELELESVKAQSLAITKQ-----NHMLNEKVKE 433
E+ AI+S +++ ++ +++V++L +++++ + ++ +Q N K K
Sbjct: 1390 SEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKA 1449
Query: 434 MSDYS----LLKEEKLELLAQNK----------LLKQQLEESRNENLRLLNRLAQPAPEL 479
S ++ +KE +++L ++K LLK++L++ L + ++
Sbjct: 1450 QSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKM 1509
Query: 480 AVFQKELR---KAEKAIVVEHE--------EFESCRQALHK-QLQDEIEHSAQL-KAQIL 526
+ L K++ A ++E E E ES + L Q +IEH + K Q
Sbjct: 1510 EKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHF 1569
Query: 527 GYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEIS 586
K + A+ K+ LEN+VY + + +N +V E+
Sbjct: 1570 QELGEEKDNRVKEAEEKI------LTLENQVYSMKAELETKKKELEHVNLSVKSKEEELK 1623
Query: 587 GDFLNNPFKQENVLARMVASRITNYPTAWVE----GSSPDSDLEFVANTKARVKELQQEA 642
L + + E+ R A ++ + + ++ T++ + EL +
Sbjct: 1624 A--LEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKL 1681
Query: 643 ERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQP 702
+ E R H +++ KS +++S +L + + KN+ + + + + V
Sbjct: 1682 QERE---REVH--ILEEKLKSVESSQSE-TLIVPRSAKNVAAYTEQEEADSQGCVQK--- 1732
Query: 703 QVGTLEERNDVVEA-LTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIA 761
T EE+ V++ LT R G S+ + E + LE
Sbjct: 1733 ---TYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHE 1789
Query: 762 SPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFK-- 819
S ++SL V+ E++ G Q + ++ F DV K +
Sbjct: 1790 DQSMIGHLQEELEEKNKKYSLI---VAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKE 1846
Query: 820 --------------------------DNEEFESSFES--------AGNMPRQLEMGGLSP 845
+ EE S +E N P +L + +
Sbjct: 1847 LTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTEL-LEENTE 1905
Query: 846 AGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVL 905
SH+ + QH ++ K ++E++K+ ++ V+ ++ R+ + QE L
Sbjct: 1906 EKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQE-L 1964
Query: 906 ERERRELEKLYQER-KMIEESLKIKIKKEL------------EMENELEMSNQEIKDKSA 952
E ++E ++ +E+ K +E L++K L + E ELEM+ +E +K+
Sbjct: 1965 EILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQ 2024
Query: 953 HSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEEL 1008
E L E QE ++ KK+ ++ D +++ + E + EE+
Sbjct: 2025 EVEAEL--------LESHQEETNQLLKKIAEKDD--DLKRTAKRYEEILDAREEEM 2070
Score = 45.8 bits (107), Expect = 2e-04
Identities = 183/914 (20%), Positives = 360/914 (39%), Gaps = 157/914 (17%)
Query: 145 KELAEYHQAKESCNMETQTSSTFN------RDSLAEKLQLIDDQF-ADAYPQRIKFESLE 197
KE ++ES N SST + DS AE L D + QR++ +E
Sbjct: 90 KESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLR--RME 147
Query: 198 IKLNEYKREIEEQLRA-EMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAK 256
L+ Y+ + E + A +M Q+ K ++ I +++ K + + + + + QAK
Sbjct: 148 RSLSSYRGKYSELVTAYQMLQREK----KKLQGILSQSQDKSLRRIAELREELQMDQQAK 203
Query: 257 SEALVLREK--STLERIHKHQEIETKEIYAQRQLLLK---DMDLLRGREAELKQRVEAFE 311
L+E+ ++LE ++ + ++ +Q L ++D+L+ +L+ + E F
Sbjct: 204 KH---LQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLP-QLEPQAEVFT 259
Query: 312 LNQKLQEEKHKSITEALRRQEQNIKSFEETYDR-KLKNELLKYQLELKDDYIIRTNRLIE 370
+EE +S E + ++K+ E R K + LLK R E
Sbjct: 260 -----KEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLK--------------RCKE 300
Query: 371 DERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEK 430
+ +KE+ L E A+ + +E Q + ++K+L + A+ + Q
Sbjct: 301 TIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHM------AEKTKLITQLRDAKNL 354
Query: 431 VKEMSDYSLLKEEKLELLAQNK-LLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKA 489
+++ L+++K ++A+ K + + LE E +L +R+ Q + +++ K+
Sbjct: 355 IEQ------LEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKS 408
Query: 490 EKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQT 549
E+A FE +AL + E E +LKA++ +K++ + ++ L+Q
Sbjct: 409 ERA------AFEELEKALSTAQKTE-EARRKLKAEM---DEQIKTIEKTSEEERISLQQE 458
Query: 550 QTALENEVYCNPKQSVIDR--SVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASR 607
+ ++ EV K+S ++ + L + E++ + + + +
Sbjct: 459 LSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKS 518
Query: 608 ITNYPTAWVEGSSPDS----DLE-----FVANTKARVKELQQEAERLEKAFRSYHRRV-- 656
+ Y E +S +LE + ++ ++++LQQEAE +Y R+
Sbjct: 519 QSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAE-------TYRTRILE 571
Query: 657 IKNSAKSPLAAKSPPSLHL---LEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDV 713
+++S + L S L LEA KN +H ++ V + LE
Sbjct: 572 LESSLEKSLQENKNQSKDLAVHLEAEKN-------KH--NKEITVMVEKHKTELESLKHQ 622
Query: 714 VEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLP 773
+AL L ++ T + K + E E + L
Sbjct: 623 QDALWTEKLQVL------KQQYQTEMEKLREKCEQE-------------------KETLL 657
Query: 774 SPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGN 833
E I ++ +K+ + + + E SE S+V K K EE +
Sbjct: 658 KDKEIIFQAHIEEMNEKTLEKLDVKQTELE-SLSSELSEVLKARHKLEEELSVLKDQTDK 716
Query: 834 MPRQLEMG-GLSPAGDMSHVDAAAAAVPLSYQHPSVDQK-QIEEQKEEEKIREQQVKERR 891
M ++LE VD+ +S Q K QI + + K R++ +KE +
Sbjct: 717 MKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQ 776
Query: 892 QREERRQSNLQEVLERERRELEK--------------LYQERKMIEESLKIKIKKELEME 937
E NL+ ++R EL++ +++ K EE L +K L++E
Sbjct: 777 AHVE----NLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLE 832
Query: 938 NELEMSNQEIKDKSAHSENP-LEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDK 996
E + +++ + A ++ E IQ + + +K + +M Q K
Sbjct: 833 TERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQ------------K 880
Query: 997 VESLTGFSHEELDD 1010
V+SLT +L+D
Sbjct: 881 VKSLTQVYESKLED 894
Score = 40.0 bits (92), Expect = 0.011
Identities = 46/182 (25%), Positives = 84/182 (46%), Gaps = 41/182 (22%)
Query: 861 LSYQHPSVDQK-----QIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKL 915
L Q+ ++QK Q+ E K E+ +EQ+ + +Q +++ + ++ E +++E+E L
Sbjct: 870 LEKQNSEMEQKVKSLTQVYESKLEDGNKEQE--QTKQILVEKENMILQMREGQKKEIEIL 927
Query: 916 YQERKMIEESLKIKIKKELEMENELEMSNQE-----IKDKSAHSENPLEKYMKIIQQE-- 968
Q+ E+S+ I L E E + NQE +K K+ + L+K K++ QE
Sbjct: 928 TQKLSAKEDSIHI-----LNEEYETKFKNQEKKMEKVKQKAKEMQETLKK--KLLDQEAK 980
Query: 969 -------------QDQESADKSSKKMVQEGS-----LVDTLQSSDK--VESLTGFSHEEL 1008
Q ++ + +M Q S V L+++ K +ESLT EL
Sbjct: 981 LKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRREL 1040
Query: 1009 DD 1010
+D
Sbjct: 1041 ND 1042
Score = 32.0 bits (71), Expect = 3.0
Identities = 28/109 (25%), Positives = 50/109 (45%), Gaps = 8/109 (7%)
Query: 876 QKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELE 935
QKE+E E +KE + + ++ L E + E +L K E+ ++ LK K+ E
Sbjct: 2007 QKEQEL--EMTIKETINKAQEVEAELLESHQEETNQLLKKIAEK---DDDLKRTAKRYEE 2061
Query: 936 MENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQE 984
+ L+ +E+ K + LE+ K QQ+ +QE + + E
Sbjct: 2062 I---LDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIME 2107
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 84.3 bits (207), Expect = 5e-16
Identities = 174/866 (20%), Positives = 357/866 (41%), Gaps = 91/866 (10%)
Query: 133 KENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIK 192
+E K +H + AE +A+E + + + +L + + A AY +I
Sbjct: 1569 QEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEE---RQLAQEERKLAQAYV-KIT 1624
Query: 193 FESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKA 252
+ E+ E K +E+ A+ +KL + ++A+ + + KK+EK + +K
Sbjct: 1625 QDDREMAQAEGKFAQKEETLAQRGEKLSQEAE-KLAQKRKKLAKKWEKVAREEEKLAKKG 1683
Query: 253 CQAKSEALVLREK-STLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFE 311
+ +L +K L + ++ + + KE+ + + L DM+ L +E EL Q
Sbjct: 1684 GKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQE----- 1738
Query: 312 LNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIED 371
KL EEK K E Q K EE + ELL ++ K+ ++ E+
Sbjct: 1739 -EGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELL---IQEKEKLAQHKEKMPEE 1794
Query: 372 ERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKV 431
E + K L E+ + + K+E +N ++EL TK +L +K
Sbjct: 1795 EERLGRKREQLIEKKMKLAQKRERW---INSMEEL--------------TKNKMILYQKK 1837
Query: 432 KEMSDYSLLKEEKLELLAQNK--LL--KQQLEESRNENLRLLNRLAQPAPELAVFQKELR 487
+ L +EK E LAQ K LL K++L S+ + +++ N+L LA +++L
Sbjct: 1838 NLAQEKKNLAQEK-EKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLT 1896
Query: 488 KAEKAIVVEHEEFESCRQALHKQLQDEI----EHSAQLKAQILGYKASVKSLTTQVADLK 543
+ ++ ++ + E+ + L Q++D + E AQ K ++ KA V+ +L
Sbjct: 1897 QEKETVIKKKEKLAETEKKL-VQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELD 1955
Query: 544 LQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARM 603
+ ++ LE + K +++ L G + + + + +
Sbjct: 1956 IAKEEKALNLEMKRLAEEKMRLVEGKET-LSKGETPETSRQRKMTQVEQELFERKLSLEE 2014
Query: 604 VASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKS 663
+ A E LEF + V Q +L KA R++IK K
Sbjct: 2015 KILLHEDRILAMEESEIAKGKLEFTRGQRIFV----QGQRKLAKA----SRKLIK---KR 2063
Query: 664 PLAAKSPPSLH-LLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAA 722
+K P L+ +L+A + +T ER + E+ +++ + ++ER
Sbjct: 2064 ESLSKEPAKLNKILKALQKLTRD--ERKLTQEEIKMTKMKRALFVKER------------ 2109
Query: 723 SRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSL 782
RLS + ++K ++ + E RS + R + R +
Sbjct: 2110 ----------RLS---IEQSKLDIKEWDFSEK--RSELTKDEKKLARKQRKLANKMRRMI 2154
Query: 783 SIPPVSSPPEQKVGLYRRQTELQDKSE--FSDVDKLAFKDNEEFESSFESAGNMPRQLEM 840
+ + E K+ + L D+ E + + + F + G+ P++
Sbjct: 2155 NKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFS 2214
Query: 841 GGLSPAGDMSHV-DAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQS 899
+ H + + + + S+ ++ EE++EEE+ E++V+E + + +
Sbjct: 2215 SQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEE 2274
Query: 900 NLQEVLERERRELEKLYQERKMIEESLKIKI---KKELEMENELE-MSNQEIKDKSAHSE 955
++ +E+E E +K +E+K E K ++ K+E+ E E E +S++E +++S E
Sbjct: 2275 GEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLE 2334
Query: 956 NPLEKYMKIIQQEQDQESADKSSKKM 981
+++ +I+++E+ + ++ K +
Sbjct: 2335 EEVDREKEILKKEKQFKLQEQRRKSL 2360
Score = 79.0 bits (193), Expect = 2e-14
Identities = 195/963 (20%), Positives = 384/963 (39%), Gaps = 101/963 (10%)
Query: 88 EYSLSVFFPESGLAKEKVFTMQDLLQLIKINPTSSLYKSL------VSGSDKENQKGFLM 141
E +S E +EKV + L +I+ P+ +K V G +++ K +
Sbjct: 1424 ERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKE 1483
Query: 142 HFLKELAE----YHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFAD-AYPQRIKFE-- 194
+ K L + HQA E + E + + E Q+ ++ + + Q+ K E
Sbjct: 1484 EWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEE 1543
Query: 195 -SLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKAC 253
+LE +++ E E+Q+ E + K I + + A+KK +E + EK
Sbjct: 1544 VTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLA 1603
Query: 254 QAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELN 313
Q + + L E+ + K + + + A+ + K+ + L R +L Q E
Sbjct: 1604 QEERQ-LAQEERKLAQAYVKITQDDREMAQAEGKFAQKE-ETLAQRGEKLSQEAEKLAQK 1661
Query: 314 QKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDER 373
+K +K + + R +E+ K + ++KN L + EL R L E+
Sbjct: 1662 RKKLAKKWEKVA---REEEKLAKKGGKL--AEVKNILAQKVEELPQ----REQNLDWQEK 1712
Query: 374 KNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKE 433
+ ++ L+ ++ ++ K+EELNQ ++ E E + + + A+ Q L+E+ +
Sbjct: 1713 ELAQELEELEWDMEELSWKEEELNQEEGKLVE---EKKKLAEEEEALAWQREKLSEEETK 1769
Query: 434 MSDYSLLKEEKLELLAQNKLLKQQLEE----SRNENLRLLNRLAQPAPELAVFQKELRKA 489
++ L ++ E LAQ+K + EE R + + +LAQ +EL K
Sbjct: 1770 LAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTK- 1828
Query: 490 EKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQT 549
K I+ + + + K L E E AQ K +L K + Q+ +K +L
Sbjct: 1829 NKMILYQKKNLAQEK----KNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMF 1884
Query: 550 QTALE--NEVYCNPKQSVIDRSVN-GLINGNVVPCNGEISGDFLNNPFKQENVLARMVAS 606
L E K++VI + +V ++ KQE + +
Sbjct: 1885 NKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAK-------KQEKLAQEKMKL 1937
Query: 607 RITNYPTAWVEGSSP-DSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKSPL 665
+ A V+G +L+ KA E+++ AE R+++ K L
Sbjct: 1938 ALEK---AMVQGKKRLRGELDIAKEEKALNLEMKRLAEE--------KMRLVE--GKETL 1984
Query: 666 AAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRL 725
+ P + ER + E++++ + ++ +EE L + R+
Sbjct: 1985 SKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRI 2044
Query: 726 -RGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSP----TESRH 780
G +S L K + SL E L + A D L T+ +
Sbjct: 2045 FVQGQRKLAKASRKLIKKRESLSKEP--AKLNKILKALQKLTRDERKLTQEEIKMTKMKR 2102
Query: 781 SLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEM 840
+L + E+++ + + + ++++ +FS+ KD ++ N R++
Sbjct: 2103 ALFV------KERRLSIEQSKLDIKE-WDFSEKRSELTKDEKKLARKQRKLANKMRRM-- 2153
Query: 841 GGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERR--- 897
++ M+ ++ A + +D ++ +EEE I + + R+++E +R
Sbjct: 2154 --INKEEKMTEEESKLAR---KHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDK 2208
Query: 898 -----QSNLQEVLERER--RELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDK 950
S + EV E E+E L E +E+ + ++E E E E E +E++++
Sbjct: 2209 PKEKFSSQVDEVESEEHFSEEMESLLDE---LEKQESLSSEEEEEREEEEEREEEEVREE 2265
Query: 951 SAHSENPLEKYMKIIQQEQDQESADKSSKKM--VQEGSLV----DTLQSSDKVESLTGFS 1004
+ E K +++E++++ K KK VQE V + + S ++ ESL+
Sbjct: 2266 EEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEE 2325
Query: 1005 HEE 1007
EE
Sbjct: 2326 EEE 2328
Score = 67.4 bits (163), Expect = 6e-11
Identities = 172/860 (20%), Positives = 350/860 (40%), Gaps = 92/860 (10%)
Query: 197 EIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAK-------------KKYEKELT 243
E K+ + KRE+ ++ R +M ++++ E +K E K KK E
Sbjct: 1410 ERKVGKIKREMTKEER-DMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWK 1468
Query: 244 MFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAEL 303
+ K+ +A E R E++H+ E ++ + ++L +D L + E
Sbjct: 1469 QVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGE----KLSPEEEMLQEDKKL---KWEEW 1521
Query: 304 KQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYII 363
KQ E L+ K +E+++K E +E + + E+ ++++ E Q E K I
Sbjct: 1522 KQVWENM-LSSKSKEQQYKDEEEVTLEEEVSREGEEK--EQQVTEEQRHIQEEHKWARIH 1578
Query: 364 RTNRLIEDERKNKEKAVHLQEELIAINSKK---EELNQSVNRVKELELELESVKAQSLAI 420
R E +R +E+ + +EE +A ++ EE + VK + + E +A+
Sbjct: 1579 RKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFA 1638
Query: 421 TKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLL---NRLAQPAP 477
K+ + K + L +++ +L + + + ++ E+ + +L N LAQ
Sbjct: 1639 QKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVE 1698
Query: 478 ELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTT 537
EL ++ L EK + E EE E + L + ++ + +L + ++L
Sbjct: 1699 ELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAW 1758
Query: 538 QVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQE 597
Q KL ++T+ A E E+ K+ + +P E G K+E
Sbjct: 1759 QRE--KLSEEETKLAQEEELLIQEKEKLAQHKEK-------MPEEEERLGR------KRE 1803
Query: 598 NVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARV----KELQQEAERLEKAFRS-- 651
++ + + ++ W+ + + + K + K L QE E+L + +
Sbjct: 1804 QLIEKKM--KLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLL 1861
Query: 652 YHRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERN 711
Y++ + +S K + K+ L F I + E+ ++ V+ ++ ++ E++
Sbjct: 1862 YNKERLTHSKKQLVQVKNK-----LGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKL 1916
Query: 712 DVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRS-HIASPSPCPDRM 770
VE +L L + + K+ L E+ + ++ ++ ++M
Sbjct: 1917 VQVEDSLAKKQEKLAQEKMKLALEKA-MVQGKKRLRGELDIAKEEKALNLEMKRLAEEKM 1975
Query: 771 PLPSPTESRHSLSIPPVSSPPEQ---KVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESS 827
L E+ P S + + L+ R+ L++K + LA +++E +
Sbjct: 1976 RLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGK 2035
Query: 828 FESAGNM------PRQLEMGG---LSPAGDMSHVDAAAAAVPLSYQHPSVDQKQI--EEQ 876
E R+L + +S A + + Q + D++++ EE
Sbjct: 2036 LEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEI 2095
Query: 877 KEEEKIREQQVKERRQREERRQSNLQEV-LERERRELEKLYQERKMIEESLKIKIKKELE 935
K + R VKERR E+ + +++E +R EL K E+K+ + K+ K
Sbjct: 2096 KMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTK--DEKKLARKQRKLANKMRRM 2153
Query: 936 MENELEMSNQEIKDKSAHSENPL--EKYMKIIQQE---------QDQESADKSSKKMVQE 984
+ E +M+ +E K HSE L E+ I ++E + ++ A + K +
Sbjct: 2154 INKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKF 2213
Query: 985 GSLVDTLQS----SDKVESL 1000
S VD ++S S+++ESL
Sbjct: 2214 SSQVDEVESEEHFSEEMESL 2233
Score = 41.6 bits (96), Expect = 0.004
Identities = 58/309 (18%), Positives = 128/309 (41%), Gaps = 32/309 (10%)
Query: 199 KLNEYKREI-EEQLRAEMCQKLKFFKDTEIA--KIKMEAKKKYEKELTMFQNDFEKACQA 255
KL +R++ +E+++ ++ F K+ ++ + K++ K+ E EK
Sbjct: 2082 KLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLAR 2141
Query: 256 KSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQK 315
K L + + + + K E E+K +++L D + E +++ L ++
Sbjct: 2142 KQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEE-----EGGIEEEEVIPFLKRR 2196
Query: 316 LQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKN 375
++ K +R ++ + F D E ++E D + + L +E +
Sbjct: 2197 WRKRKEA------KRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEE 2250
Query: 376 KEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMS 435
+E+ +EE + ++E + K++E E E K K+ E+V+E
Sbjct: 2251 REEEEEREEEEVR-EEEEERKEEEEGEEKQVEKEEEEKKK------KKKEKKKEEVQEKE 2303
Query: 436 DYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVV 495
+ + EEK E++++ + EE E+ L + + +KE+ K EK +
Sbjct: 2304 E---VFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDR--------EKEILKKEKQFKL 2352
Query: 496 EHEEFESCR 504
+ + +S R
Sbjct: 2353 QEQRRKSLR 2361
Score = 38.9 bits (89), Expect = 0.025
Identities = 52/287 (18%), Positives = 117/287 (40%), Gaps = 40/287 (13%)
Query: 229 KIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQL 288
K+ E K K + +D E+ + E + ++ +R + + KE ++ +
Sbjct: 2159 KMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQ-- 2216
Query: 289 LLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKN 348
+ +++ E++ ++ E + L E+ + E R+E+ ++ EE +RK +
Sbjct: 2217 -VDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEE--ERKEEE 2273
Query: 349 ELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELEL 408
E + Q+E E+E K K+K +EE+ EE + ++ + L
Sbjct: 2274 EGEEKQVEK------------EEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESL 2321
Query: 409 ELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNK---------------- 452
E + +S ++ ++ E +K+ + L ++ + L + +
Sbjct: 2322 SDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSILRGVPHGKGRAI 2381
Query: 453 ---LLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVE 496
+LK L++ + L + + P PE + ++ +KA VVE
Sbjct: 2382 RLGVLKSPLKKLMSTALEMKEKTPVPVPEKQISWED----KKATVVE 2424
Score = 37.0 bits (84), Expect = 0.094
Identities = 51/238 (21%), Positives = 110/238 (46%), Gaps = 20/238 (8%)
Query: 787 VSSPPEQKVGLYRRQTEL-QDKSEFS-DVDKLAFKDNEEFESSFESAGNMPRQLEMGGLS 844
V P+++ L ++ EL Q+ E D+++L++K+ E + E + + ++
Sbjct: 1697 VEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQ---EEGKLVEEKKKLAEEE 1753
Query: 845 PAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEV 904
A + L+ + + Q++ + + +EK+ E++ + R+RE+ + ++
Sbjct: 1754 EALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLA 1813
Query: 905 LERER-----RELEK----LYQERKMIEESLKIKIKKE-LEMENELEMSNQE----IKDK 950
+RER EL K LYQ++ + +E + +KE L E + N+E K +
Sbjct: 1814 QKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQ 1873
Query: 951 SAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEEL 1008
+N L + KI+ Q +++ + +K + +E L +T + +VE E+L
Sbjct: 1874 LVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKE-KLAETEKKLVQVEDSLAKKQEKL 1930
Score = 30.4 bits (67), Expect = 8.8
Identities = 31/102 (30%), Positives = 44/102 (43%), Gaps = 6/102 (5%)
Query: 402 RVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQN----KLLKQQ 457
R+K L L E + S Q E +EM + +E LL ++L Q
Sbjct: 971 RIKTLSLMAE-IGIHSRTSLLQLTQKQETFREMQQQMIGEEPLDHLLGMRATDLQILSTQ 1029
Query: 458 LEESRNENLRLLNRLAQPAPELAV-FQKELRKAEKAIVVEHE 498
+E+ NENL L +R +PA L V EL+ + K V E
Sbjct: 1030 VEQRLNENLTLSHRDEKPAFSLDVSMPSELKSSLKPPTVSEE 1071
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 84.0 bits (206), Expect = 7e-16
Identities = 183/891 (20%), Positives = 347/891 (38%), Gaps = 113/891 (12%)
Query: 169 RDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIA 228
++ LAE+LQ + FA+A R + + + +L E ++E ++ E E
Sbjct: 889 KNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEE----------EERN 938
Query: 229 KIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQL 288
+I KKK + + + ++ A+ + + EK T E K E E + Q
Sbjct: 939 QILQNEKKKMQAHIQDLEEQLDEEEGARQKLQL--EKVTAEAKIKKMEEEILLLEDQNSK 996
Query: 289 LLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKN 348
+K+ L+ R AE ++ +EEK K++ + +QE I EE R K
Sbjct: 997 FIKEKKLMEDRIAECSSQLAE-------EEEKAKNLAKIRNKQEVMISDLEE---RLKKE 1046
Query: 349 ELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELEL 408
E + +LE + +RK + LQ+++ + ++ +EL + + KE EL
Sbjct: 1047 EKTRQELE-------------KAKRKLDGETTDLQDQIAELQAQIDELKLQLAK-KEEEL 1092
Query: 409 ELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRL 468
+ + + K N + + + L ++ + E ++NK KQ+ + S E L
Sbjct: 1093 QGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLS--EELEA 1150
Query: 469 LNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIE-HSAQLKAQILG 527
L + + Q+ELR + V E L K L++E + H AQ++
Sbjct: 1151 LKTELEDTLDTTAAQQELRTKREQEVAE----------LKKALEEETKNHEAQIQDMRQR 1200
Query: 528 YKASVKSLTTQVAD---LKLQLKQTQTALE---NEVYCNPK--QSVIDRSVN--GLINGN 577
+ +++ L+ Q+ K L++ + LE E+ C K Q V S + ++
Sbjct: 1201 HATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQ 1260
Query: 578 VVPCNGEIS-GDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVK 636
V + ++S GD L ++ A + + + N T E ++F + +
Sbjct: 1261 VQELHAKVSEGDRLRVELAEK---ASKLQNELDNVSTLLEEAEK--KGIKFAKDAASLES 1315
Query: 637 ELQQEAERLEKAFR-----SYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHI 691
+LQ E L++ R S R ++ S + EA KN+
Sbjct: 1316 QLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE----EARKNLEKQVLALQS 1371
Query: 692 FGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMY 751
D +GT+E + + L A + L + L+ L K K L+ E+
Sbjct: 1372 QLADTKKKVDDDLGTIESLEEAKKKLLKDAEA-LSQRLEEKALAYDKLEKTKNRLQQELD 1430
Query: 752 LEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTE-------- 803
+ H + ++ SI + + R+ E
Sbjct: 1431 DLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLAR 1490
Query: 804 -----LQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAA 858
L+ K EF +K D E+ SS + G +LE A + +
Sbjct: 1491 ALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKS--KRALEQQVEEMRTQL 1548
Query: 859 VPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELE-KLYQ 917
L + + + ++ + + ++ Q ++ + R+E+ + + +L ++ RELE +L
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEK-KRLLIKQVRELEAELED 1607
Query: 918 ERKMIEESLKIKIKKELE-----MENELEMSNQEIKDKSAHSENPLEKYMKIIQQE---- 968
ERK + +L + KK++E +E ++E +N + +D+ L+ MK Q+E
Sbjct: 1608 ERK--QRALAVASKKKMEIDLKDLEAQIEAAN-KARDEVIKQLRKLQAQMKDYQRELEEA 1664
Query: 969 ---------QDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEELDD 1010
Q +ES K + L + L SS++ +EL D
Sbjct: 1665 RASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELAD 1715
Score = 83.2 bits (204), Expect = 1e-15
Identities = 177/873 (20%), Positives = 350/873 (40%), Gaps = 100/873 (11%)
Query: 110 DLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKEL----AEYHQAKESCNMETQTSS 165
D L+L L +L G D+ K + ++EL AE + ES +
Sbjct: 1079 DELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAE 1138
Query: 166 TFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIK----LNEYKREIEEQLRAEMCQ---- 217
RD L+E+L+ + + D + L K + E K+ +EE+ + Q
Sbjct: 1139 KQKRD-LSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM 1197
Query: 218 KLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEK-----ACQAKSEALVLREKSTLERIH 272
+ + E ++E K+++ L + E AC+ K ++ + K+ E
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVK---VLQQVKAESEHKR 1254
Query: 273 KHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRV--EAFELNQKLQEEKHKSITEA--- 327
K + + +E++A+ + + D LR AE ++ E ++ L+E + K I A
Sbjct: 1255 KKLDAQVQELHAK----VSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDA 1310
Query: 328 --LRRQEQNIKSF-EETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQE 384
L Q Q+ + +E +KL QLE + + + E+ RKN EK V +
Sbjct: 1311 ASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQ 1370
Query: 385 ELIAINSKK--------EELNQSVNRV-KELELELESVKAQSLAITKQNHMLNEKVKEMS 435
+A KK E L ++ ++ K+ E + ++ ++LA K N +E+
Sbjct: 1371 SQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELD 1430
Query: 436 DYSLLKEEKLELLA----QNKLLKQQLEESRNENLRLL---NRLAQPAPELAVFQKELRK 488
D ++ + + ++ + + K Q L E ++ + R +R A E L +
Sbjct: 1431 DLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLAR 1490
Query: 489 AEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQ 548
A + + EEFE + L ++D + + + + S ++L QV +++ QL++
Sbjct: 1491 ALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEE 1550
Query: 549 TQTALEN--------EVYCNPKQSVIDRSVNGLINGN------VVPCNGEISGDFLNNPF 594
+ L+ EV ++ +R + N ++ E+ + L +
Sbjct: 1551 LEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAE-LEDER 1609
Query: 595 KQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHR 654
KQ A VAS+ +E D + + A KAR E+ ++ +L+ + Y R
Sbjct: 1610 KQR---ALAVASKKK------MEIDLKDLEAQIEAANKAR-DEVIKQLRKLQAQMKDYQR 1659
Query: 655 RVIK-NSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDV 713
+ + +++ + A+S E+ K + S E E+ SE+ + +ER+++
Sbjct: 1660 ELEEARASRDEIFAQSK------ESEKKLKSLEAEILQLQEELASSERARRHAEQERDEL 1713
Query: 714 VEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLP 773
+ +T SA+ + RRL + + + + LE E L + D +
Sbjct: 1714 ADEITNSASGKSALLDEKRRLEAR-IAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAE 1772
Query: 774 SPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGN 833
E + QK R+Q E Q+K + + +L +F+++ +
Sbjct: 1773 LAAERSAA-----------QKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISAL-- 1819
Query: 834 MPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQR 893
+ ++G L + + AAA + + K+I Q E+E+ Q KE+ ++
Sbjct: 1820 ---EAKIGQLEEQLEQEAKERAAANKLVRRTEKKL--KEIFMQVEDERRHADQYKEQMEK 1874
Query: 894 EERRQSNLQEVLERERRELEKLYQERKMIEESL 926
R L+ LE E + R+ ++ L
Sbjct: 1875 ANARMKQLKRQLEEAEEEATRANASRRKLQREL 1907
Score = 68.2 bits (165), Expect = 4e-11
Identities = 178/894 (19%), Positives = 350/894 (39%), Gaps = 130/894 (14%)
Query: 169 RDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREI---EEQLRAEMCQKLKFFKDT 225
R L + + +D + D Q L+ +++E K ++ EE+L+ + + D
Sbjct: 1050 RQELEKAKRKLDGETTDLQDQ---IAELQAQIDELKLQLAKKEEELQGALARG----DDE 1102
Query: 226 EIAKIK-MEAKKKYEKELTMFQNDFE--KACQAKSEALVLREKSTLERIHKHQEIETKEI 282
+ K ++ ++ + ++ Q DFE KA + K+E LE + E
Sbjct: 1103 TLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTT 1162
Query: 283 YAQRQLLLKDMDLLRGRE-AELKQRVEAFELNQKLQ----EEKHKSITEALRRQEQNIKS 337
AQ++L K R +E AELK+ +E N + Q ++H + E L Q + K
Sbjct: 1163 AAQQELRTK-----REQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKR 1217
Query: 338 FEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKK---- 393
F+ ++ K L EL + + E E K K+ +QE ++
Sbjct: 1218 FKANLEKN-KQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRV 1276
Query: 394 ---EELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEE---KLEL 447
E+ ++ N + + LE + + + K L ++++ + LL+EE KL L
Sbjct: 1277 ELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQE--LLQEETRQKLNL 1334
Query: 448 LAQNKLLKQQ---LEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCR 504
++ + L+++ L+E + E L + ++ Q +L +K + + ES
Sbjct: 1335 SSRIRQLEEEKNSLQEQQEEEEEARKNLEK---QVLALQSQLADTKKKVDDDLGTIESLE 1391
Query: 505 QALHKQLQDEIEHSAQLKAQILGYKASVKS---LTTQVADLKLQLKQTQTALENEVYCNP 561
+A K L+D S +L+ + L Y K+ L ++ DL + L + N
Sbjct: 1392 EAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASN---LEK 1448
Query: 562 KQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSP 621
KQ D+ + +++++ AR R A E
Sbjct: 1449 KQKKFDQLLA-----------------------EEKSISARYAEER----DRAEAEAREK 1481
Query: 622 DSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKN 681
++ +A E ++E ER K R+ ++ S+K + ++H LE K
Sbjct: 1482 ETKALSLARALEEALEAKEEFERQNKQLRADMEDLM--SSKDDVGK----NVHELEKSKR 1535
Query: 682 ITSSSPERHIFGEDRVVSEQPQVGTLEERNDV-VEALTGSAASRLRGGTSSRRLSSTPLP 740
E + + E + R +V ++A+ L+ L
Sbjct: 1536 ALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595
Query: 741 KAKRSLESEMYLEGLGRS-HIASPSPCP-DRMPLPSPTESRHSLSIPPVSSPPEQKVGLY 798
K R LE+E+ E R+ +AS D L + E+ + + + + +
Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655
Query: 799 RRQTELQDKSEFSDVDKLAFKDNEEFESSFE-----------SAGNMPRQLEMGGLSPAG 847
Q EL++ D K++E+ S E S+ R E A
Sbjct: 1656 DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELAD 1715
Query: 848 DMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKER----------------- 890
++++ + +A+ + Q+EE+ EEE+ + + +R
Sbjct: 1716 EITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAA 1775
Query: 891 RQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKEL--------EMENELEM 942
+ ++ N ++ LER+ +EL+ QE +E ++K K K + ++E +LE
Sbjct: 1776 ERSAAQKSDNARQQLERQNKELKAKLQE---LEGAVKSKFKATISALEAKIGQLEEQLE- 1831
Query: 943 SNQEIKDKSAHSE--NPLEKYMK--IIQQEQDQESADKSSKKMVQEGSLVDTLQ 992
QE K+++A ++ EK +K +Q E ++ AD+ ++M + + + L+
Sbjct: 1832 --QEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLK 1883
Score = 55.5 bits (132), Expect = 3e-07
Identities = 130/638 (20%), Positives = 264/638 (41%), Gaps = 79/638 (12%)
Query: 370 EDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKE-------LELELESVKAQSLAITK 422
E+ K KEK ++ EL + K ++L + N + E L E E ++A+ LA K
Sbjct: 859 EELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRAR-LAAKK 917
Query: 423 QN-----HMLNEKVKEMSDYS-LLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPA 476
Q H L +V+E + + +L+ EK ++ A + L++QL+E +L +L +
Sbjct: 918 QELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKL--QLEKVT 975
Query: 477 PELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLT 536
E + + E E+ +++E + + ++ K ++D I A+ +Q+ + K+L
Sbjct: 976 AEAKIKKME----EEILLLEDQNSKFIKEK--KLMEDRI---AECSSQLAEEEEKAKNLA 1026
Query: 537 TQVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNGL---INGNVVPCNGEISGDFLNNP 593
++ + + L+ E + R ++G + + +I L
Sbjct: 1027 KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA 1086
Query: 594 FKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYH 653
K+E + + E ++ L+ V +A++ ELQ++ E EKA R+
Sbjct: 1087 KKEEELQGALARGDD--------ETLHKNNALKVVRELQAQIAELQEDFES-EKASRNKA 1137
Query: 654 RRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDV 713
+ ++ ++ A K+ LE + T++ E E V + LEE
Sbjct: 1138 EKQKRDLSEELEALKTE-----LEDTLDTTAAQQELRTKREQEVAELKK---ALEEETKN 1189
Query: 714 VEALTGSAASRLRGGTSSRRLSSTPLPKAKR-SLESEMYLEGLGRSHIASPSPCPDRMPL 772
EA R R T+ LS L +AKR E +GL + C ++
Sbjct: 1190 HEAQIQDM--RQRHATALEELSEQ-LEQAKRFKANLEKNKQGLETDN--KELACEVKVLQ 1244
Query: 773 PSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDN-EEFESSFESA 831
ES H ++ L + EL K D ++ + + ++ ++
Sbjct: 1245 QVKAESEH------------KRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNV 1292
Query: 832 GNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQ-------KQIEEQKEEEKIRE 884
+ + E G+ A D + +++ Q + + +Q+EE+K + ++
Sbjct: 1293 STLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQ 1352
Query: 885 QQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSN 944
++ +E R+ E++ LQ L +++++ + +EE+ K +K + E +
Sbjct: 1353 EEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK-------DAEALS 1405
Query: 945 QEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMV 982
Q +++K A + + LEK +QQE D + D ++ V
Sbjct: 1406 QRLEEK-ALAYDKLEKTKNRLQQELDDLTVDLDHQRQV 1442
Score = 49.7 bits (117), Expect = 1e-05
Identities = 59/269 (21%), Positives = 122/269 (45%), Gaps = 29/269 (10%)
Query: 192 KFESLEIKLNEYKREIEE------QLRAEMCQKLKFFKDTEIAKIKME--------AKKK 237
+ L+ ++ +Y+RE+EE ++ A+ + K K E ++++ A++
Sbjct: 1646 QLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRH 1705
Query: 238 YEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLL-------L 290
E+E ++ + KS +L EK LE E E +E + +LL
Sbjct: 1706 AEQERDELADEITNSASGKSA--LLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTT 1763
Query: 291 KDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKS-FEETYDR-KLKN 348
+D L A + + + ++ E ++K + L+ E +KS F+ T + K
Sbjct: 1764 LQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKI 1823
Query: 349 ELLKYQLELKDDYIIRTNRLIE-DERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELE 407
L+ QLE + N+L+ E+K KE + +++E + KE++ ++ R+K+L+
Sbjct: 1824 GQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLK 1883
Query: 408 LELESVKAQSLAITKQNHMLNEKVKEMSD 436
+LE + ++ T+ N + +E+ D
Sbjct: 1884 RQLEEAEEEA---TRANASRRKLQRELDD 1909
Score = 37.0 bits (84), Expect = 0.094
Identities = 22/112 (19%), Positives = 58/112 (51%), Gaps = 8/112 (7%)
Query: 872 QIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIK 931
Q+ Q+EE + +++++ + ++++ + + L+E+ R+ ++L +E+ ++ E L +
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEM----ERKHQQLLEEKNILAEQL----Q 897
Query: 932 KELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQ 983
E E+ E E + K E L +++E+++ ++ KK +Q
Sbjct: 898 AETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQ 949
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 83.6 bits (205), Expect = 9e-16
Identities = 185/930 (19%), Positives = 350/930 (37%), Gaps = 101/930 (10%)
Query: 100 LAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHF---LKELAEYHQAKES 156
LAKEK ++D + N T KS K + + L+ + Q E
Sbjct: 990 LAKEKKL-LEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEK 1048
Query: 157 CNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMC 216
+ + ST D +AE ++ + E+K+ K+E E+L+A +
Sbjct: 1049 TRRKLEGDSTDLSDQIAE----------------LQAQIAELKMQLAKKE--EELQAALA 1090
Query: 217 QKLKFFKDTEIAKIKMEAKK--KYEKELTMFQNDFE--KACQAKSEALVLREKSTLERIH 272
+ + E A+ M KK + E +++ Q D E +A + K+E LE +
Sbjct: 1091 RV-----EEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALK 1145
Query: 273 KHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQE 332
E AQ++L K + + L++ + E + +KH E L Q
Sbjct: 1146 TELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQL 1205
Query: 333 QNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSK 392
+ K + + K K L + EL ++ + + E K K+ LQE + N
Sbjct: 1206 EQTKRVKANLE-KAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEG 1264
Query: 393 KEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNK 452
+ + ++V +L++EL++V + Q+ + K+ + D+S L+ +Q +
Sbjct: 1265 ERVRTELADKVTKLQVELDNV----TGLLSQSDSKSSKLTK--DFSALE-------SQLQ 1311
Query: 453 LLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQ 512
++ L+E + L L +L Q E F+++L + E+A E LH Q+
Sbjct: 1312 DTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEA----KHNLEKQIATLHAQVA 1367
Query: 513 DE----------IEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPK 562
D +E + ++K ++ + + +L++T+T L+ E
Sbjct: 1368 DMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQE------ 1421
Query: 563 QSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPD 622
+D + L + CN E + +E ++ A A E +
Sbjct: 1422 ---LDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAE---ERDRAEAEAREKE 1475
Query: 623 SDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNI 682
+ +A E + E ERL K FR+ ++ S+K + S+H LE K
Sbjct: 1476 TKALSLARALEEAMEQKAELERLNKQFRTEMEDLM--SSKDDVG----KSVHELEKSKRA 1529
Query: 683 TSSSPERHIFGEDRVVSEQPQVGTLEERNDV-VEALTGSAASRLRGGTSSRRLSSTPLPK 741
E + + E + R +V ++A+ L+G L +
Sbjct: 1530 LEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVR 1589
Query: 742 AKRSLESEMYLEGLGRSH--IASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYR 799
R +E+E+ E RS A D L + +S + + + + +
Sbjct: 1590 QVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD 1649
Query: 800 RQTELQDKSEFSDVDKLAFKDNEEFESSFE-----------SAGNMPRQLEMGGLSPAGD 848
EL D + K+NE+ S E +A RQ + A +
Sbjct: 1650 CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADE 1709
Query: 849 MSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERE 908
+++ A + Q+EE+ EEE+ + + +R ++ + + L E
Sbjct: 1710 IANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLE 1769
Query: 909 RRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQE 968
R +K R+ +E K E++ +L+ +K K S LE + ++++
Sbjct: 1770 RSHAQKNENARQQLERQNK-------ELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQ 1822
Query: 969 QDQESADKSSK-KMVQ--EGSLVDTLQSSD 995
D E+ ++ + K V+ E L D L D
Sbjct: 1823 LDNETKERQAACKQVRRTEKKLKDVLLQVD 1852
Score = 71.6 bits (174), Expect = 3e-12
Identities = 165/861 (19%), Positives = 338/861 (39%), Gaps = 123/861 (14%)
Query: 174 EKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKME 233
E+L + ++ A + + E+L+ +L K +++EQL+AE + + E + ++
Sbjct: 852 EELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAET----ELCAEAEELRARLT 907
Query: 234 AKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDM 293
AKK+ EL +D E + + E +H + E K++ Q
Sbjct: 908 AKKQ---ELEEICHDLEARVEEEEERC------------QHLQAEKKKMQQNIQ------ 946
Query: 294 DLLRGREAELKQRVEAFE-LNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLK 352
EL++++E E QKLQ EK + + + +E+ I ++ +L K
Sbjct: 947 --------ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNC------KLAK 992
Query: 353 YQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELES 412
+ L+D T L E+E K+K A + I +E L + + +ELE
Sbjct: 993 EKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRK 1052
Query: 413 VKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKL----------------------ELLAQ 450
++ S ++ Q L ++ E+ KEE+L EL +Q
Sbjct: 1053 LEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQ 1112
Query: 451 NKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQ----A 506
L++ LE R + + EL + EL + + +E S R+
Sbjct: 1113 ISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQ-QELRSKREQEVNI 1171
Query: 507 LHKQLQDEIE-HSAQLKAQILGYKASVKSLTTQVAD---LKLQLKQTQTALENEVYCNPK 562
L K L++E + H AQ++ + +V+ L Q+ +K L++ + LENE
Sbjct: 1172 LKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENE------ 1225
Query: 563 QSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPD 622
+ + V L+ G GD + K++ V A++ ++ V D
Sbjct: 1226 RGELANEVKVLLQG---------KGD---SEHKRKKVEAQLQELQVKFNEGERVRTELAD 1273
Query: 623 SDLEF---VANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHLLEAF 679
+ + N + + ++ +L K F + ++ + L ++ L L
Sbjct: 1274 KVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQL--QDTQELLQEENRQKLSLSTKL 1331
Query: 680 KNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPL 739
K + E++ F E ++ E+ LE++ + A ++ +
Sbjct: 1332 KQV---EDEKNSFRE-QLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE--- 1384
Query: 740 PKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYR 799
+ KR L+ + LEGL + H + + + + + + L +
Sbjct: 1385 -EVKRKLQKD--LEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEK 1441
Query: 800 RQTELQD--------KSEFSDVDKLAFKDNEEFES-------SFESAGNMPRQLEMGGLS 844
+Q + +++++ A + E E+ + E A +LE
Sbjct: 1442 KQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQ 1501
Query: 845 PAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEV 904
+M + ++ V S ++ +E+Q EE K + +++++ Q E + L+
Sbjct: 1502 FRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVN 1561
Query: 905 LERERRELEKLYQER-KMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMK 963
L+ + + E+ Q R + EE K +++ EME ELE ++ + + + LE +K
Sbjct: 1562 LQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQ-RSMAVAARKKLEMDLK 1620
Query: 964 IIQQEQDQESADKSSKKMVQE 984
++ D SA+K+ + +++
Sbjct: 1621 DLEAHID--SANKNRDEAIKQ 1639
Score = 57.8 bits (138), Expect = 5e-08
Identities = 160/852 (18%), Positives = 336/852 (39%), Gaps = 128/852 (15%)
Query: 199 KLNEYKREIEEQLRAEMCQK-LKFFKDTEIAKIKM---EAKKKYEKELTMFQNDFEKACQ 254
+L K E+E+ L + Q+ L+ ++ E+ +K E K +E ++ + +A +
Sbjct: 1140 ELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE 1199
Query: 255 AKSEAL--VLREKSTLERIHKHQEIETKEIYAQRQLLLK---DMDLLRGR-EAELKQRVE 308
+E L R K+ LE+ + E E E+ + ++LL+ D + R + EA+L++
Sbjct: 1200 ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQV 1259
Query: 309 AFELNQKLQEEKHKSITEALRRQEQNIK---SFEETYDRKLKNELLKYQLELKDDYIIRT 365
F ++++ E +T+ L+ + N+ S ++ KL + + +L+D T
Sbjct: 1260 KFNEGERVRTELADKVTK-LQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQD-----T 1313
Query: 366 NRLIEDERKNK-EKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQ- 423
L+++E + K + L++ NS +E+L + LE ++ ++ AQ + K+
Sbjct: 1314 QELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKM 1373
Query: 424 ----------NHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLA 473
+ + K++ S EEK+ + + K +L++ ++ L L+
Sbjct: 1374 EDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQR 1433
Query: 474 QPAPELAVFQK---ELRKAEKAIVVEHEEFESCRQA-----------LHKQLQDEIEHSA 519
Q A L QK +L EK I ++ E +A L + L++ +E A
Sbjct: 1434 QSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKA 1493
Query: 520 QLKAQILGYKASVKSLTTQVADLKL---QLKQTQTALENEV---------YCNPKQSVID 567
+L+ ++ ++ L + D+ +L++++ ALE +V + Q+ D
Sbjct: 1494 ELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATED 1553
Query: 568 RSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEF 627
+ + N+ + D + E ++V R A +E +
Sbjct: 1554 AKLR--LEVNLQAMKAQFERDLQGRDEQSEEKKKQLV--RQVREMEAELEDERKQRSMAV 1609
Query: 628 VANTKARV--KELQQEAERLEKAFRSYHRRVIKNSAK---------SPLAAKSPPSLHLL 676
A K + K+L+ + K +++ K A+ A++
Sbjct: 1610 AARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAK 1669
Query: 677 EAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSS 736
E K + S E E+ +E+ + +ER+++ + + S+ RRL +
Sbjct: 1670 ENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEA 1729
Query: 737 TPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVG 796
+ + + LE E L + + D++ E H+ QK
Sbjct: 1730 R-IAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHA-----------QKNE 1777
Query: 797 LYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAA 856
R+Q E Q N+E + + EM G + + + A
Sbjct: 1778 NARQQLERQ---------------NKELKVKLQ---------EMEGTVKSKYKASITALE 1813
Query: 857 AAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLY 916
A + Q+EEQ + E Q ++ +R E++ ++ ++ ERR E+
Sbjct: 1814 AKIA-----------QLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYK 1862
Query: 917 QERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADK 976
+ LK +++ +LE + +E + +A S L++ ++ + D + +
Sbjct: 1863 DQADKASTRLK-------QLKRQLEEAEEEAQRANA-SRRKLQRELEDATETADAMNREV 1914
Query: 977 SS-KKMVQEGSL 987
SS K ++ G L
Sbjct: 1915 SSLKNKLRRGDL 1926
Score = 52.8 bits (125), Expect = 2e-06
Identities = 92/462 (19%), Positives = 188/462 (40%), Gaps = 81/462 (17%)
Query: 108 MQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTF 167
M+DL+ K + S+++ S E Q + L+EL + QA E + + +
Sbjct: 1506 MEDLMSS-KDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQA 1564
Query: 168 NRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEI 227
+ LQ D+Q + Q ++ RE+E +L E Q+
Sbjct: 1565 MKAQFERDLQGRDEQSEEKKKQLVR----------QVREMEAELEDERKQR--------- 1605
Query: 228 AKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIET-----KEI 282
+ + A+KK E +L + + A + + EA+ K + +E++ +EI
Sbjct: 1606 -SMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEI 1664
Query: 283 YAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEAL-------------- 328
AQ + K + + +L++ + A E ++ +++ + + +
Sbjct: 1665 LAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEK 1724
Query: 329 RRQEQNIKSFEETYDRKLKN-ELLKYQLELKDDYI--IRTNRLIED-------------E 372
RR E I EE + + N EL+ +L+ + I I T+ +E E
Sbjct: 1725 RRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLE 1784
Query: 373 RKNKEKAVHLQEELIAINSK-KEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKV 431
R+NKE V LQE + SK K + ++ +LE +L++ + A KQ +K+
Sbjct: 1785 RQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKL 1844
Query: 432 KEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEK 491
K++ LL Q+++ R + ++ + + L +++L +AE+
Sbjct: 1845 KDV------------------LL--QVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEE 1884
Query: 492 AIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVK 533
E + + R+ L ++L+D E + + ++ K ++
Sbjct: 1885 ----EAQRANASRRKLQRELEDATETADAMNREVSSLKNKLR 1922
Score = 43.1 bits (100), Expect = 0.001
Identities = 34/164 (20%), Positives = 74/164 (45%), Gaps = 1/164 (0%)
Query: 836 RQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREE 895
R+LE + ++ + A A + + + + + EEE ++ ++ + E
Sbjct: 1051 RKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELE 1110
Query: 896 RRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSE 955
+ S LQE LE ER K ++++ + E L+ +K ELE + + QE++ K
Sbjct: 1111 SQISELQEDLESERASRNKAEKQKRDLGEELE-ALKTELEDTLDSTAAQQELRSKREQEV 1169
Query: 956 NPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVES 999
N L+K ++ + + + + K L + L+ + +V++
Sbjct: 1170 NILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKA 1213
Score = 43.1 bits (100), Expect = 0.001
Identities = 69/326 (21%), Positives = 141/326 (43%), Gaps = 58/326 (17%)
Query: 164 SSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFK 223
S+ NRD ++L+ + Q D + + ++ +E E++L++ + ++ +
Sbjct: 1628 SANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQE 1687
Query: 224 DTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIY 283
+ A+ AK++ ++E ++ A + AL L EK LE E E +E
Sbjct: 1688 ELAAAE---RAKRQAQQERDELADEI--ANSSGKGALALEEKRRLEARIAQLEEELEEEQ 1742
Query: 284 AQRQLL---LK-----------DMDLLRG---REAELKQRVEAF--ELNQKLQE------ 318
+L+ LK D++L R + +Q++E EL KLQE
Sbjct: 1743 GNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVK 1802
Query: 319 EKHKSITEALRRQEQNIKSFEETYDRKLKN------ELLKYQLELKDDYIIRTNRLIEDE 372
K+K+ AL E I EE D + K ++ + + +LKD + ++DE
Sbjct: 1803 SKYKASITAL---EAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLL-----QVDDE 1854
Query: 373 RKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVK 432
R+N E+ K++ +++ R+K+L+ +LE + ++ L +++
Sbjct: 1855 RRNAEQY-------------KDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELE 1901
Query: 433 EMSDYSLLKEEKLELLAQNKLLKQQL 458
+ ++ + ++ L +NKL + L
Sbjct: 1902 DATETADAMNREVSSL-KNKLRRGDL 1926
Score = 42.4 bits (98), Expect = 0.002
Identities = 34/129 (26%), Positives = 61/129 (47%), Gaps = 14/129 (10%)
Query: 877 KEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEM 936
+EE K E Q++E RQ+ + L E LE+ +R L + ++ +E + E+
Sbjct: 1177 EEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLE-------NERGEL 1229
Query: 937 ENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQ------ESADKSSKKMVQEGSLVDT 990
NE+++ Q K S H +E ++ +Q + ++ E ADK +K V+ ++
Sbjct: 1230 ANEVKVLLQG-KGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGL 1288
Query: 991 LQSSDKVES 999
L SD S
Sbjct: 1289 LSQSDSKSS 1297
Score = 38.9 bits (89), Expect = 0.025
Identities = 31/125 (24%), Positives = 69/125 (55%), Gaps = 13/125 (10%)
Query: 872 QIEEQKEEEKIREQQ---VKERRQREERR---QSNLQEVLERERREL-EKLYQERKMIEE 924
Q+ Q+EE +E++ V+E++ E R LQ L E+ +L E+L E ++ E
Sbjct: 839 QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898
Query: 925 SLKIKIK---KELEME---NELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSS 978
+ +++ + K+ E+E ++LE +E +++ H + +K + IQ+ ++Q ++S+
Sbjct: 899 AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA 958
Query: 979 KKMVQ 983
++ +Q
Sbjct: 959 RQKLQ 963
Score = 37.0 bits (84), Expect = 0.094
Identities = 37/153 (24%), Positives = 67/153 (43%), Gaps = 30/153 (19%)
Query: 873 IEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLK----- 927
+E + EEE+ R Q ++ +++ ++ L+E LE E +KL E+ E LK
Sbjct: 920 LEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEE 979
Query: 928 -----------IKIKKELE---------MENELEMSNQEIKDKSAHSENPLEKYMKIIQQ 967
K KK LE + E E S K K+ H + ++ ++
Sbjct: 980 QIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRRE 1039
Query: 968 EQDQESADKSSKKMVQEGSLVDTLQSSDKVESL 1000
E+ ++ +K+ +K+ EG D+ SD++ L
Sbjct: 1040 EKQRQELEKTRRKL--EG---DSTDLSDQIAEL 1067
Score = 35.4 bits (80), Expect = 0.27
Identities = 34/153 (22%), Positives = 73/153 (47%), Gaps = 28/153 (18%)
Query: 869 DQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEV-------LERERRELEKLYQERKM 921
++ Q++EQ + E + +E R R ++ L+E+ +E E + L E+K
Sbjct: 881 EKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKK 940
Query: 922 IEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKY---MKIIQQEQDQESADKSS 978
++++++ E+E +LE +++SA + LEK K+ + E++Q + +
Sbjct: 941 MQQNIQ-------ELEEQLE------EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQN 987
Query: 979 KKMVQEGSLVDTLQSSDKVESLTGFSHEELDDS 1011
K+ +E L++ D++ T EE + S
Sbjct: 988 CKLAKEKKLLE-----DRIAEFTTNLTEEEEKS 1015
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 80.5 bits (197), Expect = 7e-15
Identities = 93/426 (21%), Positives = 200/426 (46%), Gaps = 38/426 (8%)
Query: 125 KSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFA 184
+SL ++E+Q + L+ E + K+ C ++ S + D L +++ ++ +
Sbjct: 2287 QSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELE 2346
Query: 185 DAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTM 244
A R E ++ K E+E L+A++ + + E+ + + ++K+ LT
Sbjct: 2347 IA---RTNQEHAALEAENSKGEVET-LKAKIEGMTQSLRGLELDVVTIRSEKE---NLT- 2398
Query: 245 FQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELK 304
N+ +K + SE ++ S+ E I + +E E ++ + M++L+ + EL
Sbjct: 2399 --NELQKEQERISELEIIN--SSFENILQEKEQEKVQMKEKSSTA---MEMLQTQLKELN 2451
Query: 305 QRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYII- 363
+RV A +Q EA + +EQN+ S E + + K +LL+ E K++YI+
Sbjct: 2452 ERVAALHNDQ-----------EACKAKEQNLSSQVECLELE-KAQLLQGLDEAKNNYIVL 2499
Query: 364 --RTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAIT 421
N LI++ K+K EE+ + ++ ++ Q V+++ ++E E + K Q+L +
Sbjct: 2500 QSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELR 2559
Query: 422 KQNHMLNEKVKEMSDYSLLKEEKLELLAQN-KLLKQQLEESRNENLRLLNRLAQPAPELA 480
L +K++ + + ++ LE+L + K L+ +LE ++ + + + ++ + +
Sbjct: 2560 NLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKET 2619
Query: 481 VFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVA 540
Q+E+ + + EE + L +LQ +E +I K +K LT + +
Sbjct: 2620 ELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLE-------EIKSSKDQLKELTLENS 2672
Query: 541 DLKLQL 546
+LK L
Sbjct: 2673 ELKKSL 2678
Score = 70.1 bits (170), Expect = 1e-11
Identities = 173/864 (20%), Positives = 350/864 (40%), Gaps = 128/864 (14%)
Query: 178 LIDDQFADAYPQRIKFESLEIKLNEYKREIE-------------EQLRAEMCQKLKFFKD 224
L+D A R K LE++L +++E++ E+ + E+ +K K
Sbjct: 279 LLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNK 338
Query: 225 TEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYA 284
++ A +Y++ T + +K + + R+ + R Q+I+ KE
Sbjct: 339 CRDELVRTTA--QYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEF 396
Query: 285 QRQLLLK-------DMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKS 337
Q +L + D + ++ + ++ +A ++ LQ E K +T ++ E N++
Sbjct: 397 QEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDK-LTSVKQQLENNLEE 455
Query: 338 FEETYDRK---------LKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAV-HLQEELI 387
F++ R +NEL + E+K + N L++ + K + V HL+ EL
Sbjct: 456 FKQKLCRAEQAFQASQIKENELRRSMEEMK-----KENNLLKSHSEQKAREVCHLEAELK 510
Query: 388 AINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLEL 447
I K+ LNQS N +E+ KA++ + L EK+ + + L++ KL +
Sbjct: 511 NI---KQCLNQSQNFAEEM-------KAKNTSQETMLRDLQEKINQQENSLTLEKLKLAV 560
Query: 448 --LAQNKLLKQQLEESRNENLRLLN-RLAQPAPELAVFQK--ELRKAEKAIVVEHEEFES 502
L + + Q L + R ++ LN +L++ E EL+K E + E + S
Sbjct: 561 ADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFS 620
Query: 503 CRQALHKQLQDEIEHSAQ-LKAQILGYKASVKSLTTQVADLKLQLKQTQTALEN-EVYCN 560
C ++ +++L ++E + L+++I + +K+ + + +++ + EN V
Sbjct: 621 CWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIR 680
Query: 561 PKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSS 620
+V+D + + + +F + ++E + S++T +
Sbjct: 681 NLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTG------QVED 734
Query: 621 PDSDLEFVAN---TKAR-VKELQQEAERLEKAFRSYHRRVIKNS--AKSPLAAKSPPSLH 674
+ L+ ++N K R ++L E E L +S ++ N +S LA P++H
Sbjct: 735 LEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMH 794
Query: 675 LLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRL 734
+F NI I + + SE+ + +++ A+ + L S++
Sbjct: 795 --HSFANI--------IGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQ 844
Query: 735 SSTPLPKAKRSL--------ESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPP 786
++ L K L E+ M E + +S +A S R+ S H +
Sbjct: 845 MNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETS---QRISKLQEDTSAHQNVVAE 901
Query: 787 VSSPPEQKVGLYRRQTELQDK--SEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLS 844
S E K + L DK +E +++ +L K N E S + + L +
Sbjct: 902 TLSALENK---EKELQLLNDKVETEQAEIQELK-KSNHLLEDSLKELQLLSETLSL---- 953
Query: 845 PAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEE----EKIREQQVKERRQREERRQSN 900
+MS + S+++++IEE +E ++I +E+ ++ +S
Sbjct: 954 EKKEMSSI-------------ISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESF 1000
Query: 901 LQEVLERER--RELEKLYQERKMI-----------EESLKIKIKKELEMENELEMSNQEI 947
+ ERE+ EL Y++ K+I E L K K E ++LE E
Sbjct: 1001 ANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNEC 1060
Query: 948 KDKSAHSENPLEKYMKIIQQEQDQ 971
+ +N LE+ + +E +
Sbjct: 1061 TSLCENRKNELEQLKEAFAKEHQE 1084
Score = 68.9 bits (167), Expect = 2e-11
Identities = 185/955 (19%), Positives = 399/955 (41%), Gaps = 163/955 (17%)
Query: 98 SGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESC 157
S L K+K + L L K + SL K + ENQ +A+ ++ KE
Sbjct: 2024 SELLKDKTHLQEKLQSLEKDSQALSLTKC-----ELENQ----------IAQLNKEKELL 2068
Query: 158 NMETQTSSTFNRDSLAEKLQL---IDDQFADAYPQRIKFESLEIKLNEYKREIEE-QLRA 213
E+++ +S EKL + ++ + ++ S + ++++ +R IE+ ++R
Sbjct: 2069 VKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRI 2128
Query: 214 EMCQKLKF-----FKDTEIAKIKMEAK-KKYEKELTMFQNDFE----KACQAKSEALVLR 263
E +K + K+ E ++ K + E+EL M + + E A +K+E L+
Sbjct: 2129 EADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLK 2188
Query: 264 EK-STLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFE--LNQKLQ--- 317
+ + R K E++ + ++++ L K + +G+ +EL + + +F+ L +K Q
Sbjct: 2189 TQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEI 2248
Query: 318 --EEKHKSITEALRRQ--------------EQNIKSFEETYD------RKLKNELLKYQL 355
+E+ K+ E L+ Q ++ +K+ E++ D +L+N + K +
Sbjct: 2249 QIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRA 2308
Query: 356 ELKDD---YIIRTNRLIEDERKN---KEKAVHLQEELIAINSKKE----ELNQSVNRVKE 405
L+ D + +L E E K + +L+ EL + +E E S V+
Sbjct: 2309 RLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVET 2368
Query: 406 LELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKL--ELLAQNKLLKQQLEESRN 463
L+ ++E + QSL + + + KE L KE++ EL N + L+E
Sbjct: 2369 LKAKIEGM-TQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQ 2427
Query: 464 ENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKA 523
E +++ + + + + Q +L++ + + H + E+C+ A + L ++E KA
Sbjct: 2428 EKVQMKEK---SSTAMEMLQTQLKELNERVAALHNDQEACK-AKEQNLSSQVECLELEKA 2483
Query: 524 QILG-----------YKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNG 572
Q+L ++SV L +V D K +L++ ++E K + D+
Sbjct: 2484 QLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEK-----KDEEISRLKNQIQDQE--- 2535
Query: 573 LINGNVVPCNGEISGDFLNNPFKQENV-LARMVASRITNYPTAWVEGSSPDSDLEFVANT 631
+V ++ G+ + +K++N+ L + + +S LE +
Sbjct: 2536 ----QLVSKLSQVEGE--HQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVL--- 2586
Query: 632 KARVKELQQEAERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHI 691
++ K L+ E E + S+ +V K +AK + + A S + +
Sbjct: 2587 QSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRL 2646
Query: 692 FGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSL-ESEM 750
GE +++ E+ ++ D ++ LT L ++ L K+ + + ++
Sbjct: 2647 AGELQLLLEE-----IKSSKDQLKELT---------------LENSELKKSLDCMHKDQV 2686
Query: 751 YLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDK--- 807
EG R IA + E +H + + E ++ YR + +++
Sbjct: 2687 EKEGKVREEIA------EYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLS 2740
Query: 808 SEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPS 867
S+ ++D L EE +S ++ + +L+ + L Y
Sbjct: 2741 SQKLEIDLLK-SSKEELNNSLKATTQILEELKKTKMD---------------NLKY---- 2780
Query: 868 VDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLK 927
V+Q + E ++ + K++ +K +Q EE + E+L++E +L+ QE++ +
Sbjct: 2781 VNQLKKENERAQGKMK-LLIKSCKQLEEEK-----EILQKELSQLQAA-QEKQKTGTVMD 2833
Query: 928 IKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMV 982
K+ E+ E++ + +++K+ ++ L+KY ++ + E A + + V
Sbjct: 2834 TKVD---ELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQV 2885
Score = 65.5 bits (158), Expect = 2e-10
Identities = 159/797 (19%), Positives = 303/797 (38%), Gaps = 86/797 (10%)
Query: 222 FKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKE 281
F D + ++ K +EL N+ E Q EK +++K QE++ +
Sbjct: 270 FFDNSSSPHLLDQLKAQNQELRNKINELELRLQG-------HEKEMKGQVNKFQELQLQL 322
Query: 282 IYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQ--EEKHKSITEALRRQEQNIKSFE 339
A+ +L+ K+ L + R+ ++ + + + K E+K K +TE L Q QN +S
Sbjct: 323 EKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESAR 382
Query: 340 ETYDRKLKNELLKYQLELK----------DDYIIRTNRLIEDERKNKEKAVHLQEELIAI 389
+ ++K+K + ++Q EL + I RL ++ ++ K LQ EL +
Sbjct: 383 CSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKL 442
Query: 390 NSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLK-------E 442
S K++L ++ K+ E +A + K+N + + + +LLK
Sbjct: 443 TSVKQQLENNLEEFKQKLCRAE--QAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAR 500
Query: 443 EKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEH----- 497
E L A+ K +KQ L +S+N + + L Q+++ + E ++ +E
Sbjct: 501 EVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAV 560
Query: 498 ---EEFESCRQALHKQLQDEIEH-SAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTAL 553
E+ C Q L K+ + IE + +L KA + +L + + + +LK+ +T
Sbjct: 561 ADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYE-ELKEEKTLF 619
Query: 554 -----ENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRI 608
ENE +S + + + + +I N + + ++ I
Sbjct: 620 SCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEI 679
Query: 609 TNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSA--KSPLA 666
N DS V K ELQQ+AE ++ H++ I+N S L
Sbjct: 680 RNLHNVL------DSKSVEVETQKLAYMELQQKAEFSDQK----HQKEIENMCLKTSQLT 729
Query: 667 AKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLR 726
+ H L+ N I +DR + E + + L AS +
Sbjct: 730 GQVEDLEHKLQLLSN--------EIMDKDRCYQD-----LHAEYESLRDLLKSKDASLVT 776
Query: 727 GGTSSRR-LSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIP 785
R L+ P S + + +G S + D+ P S S+
Sbjct: 777 NEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLE 836
Query: 786 -PVSSPPEQKVGLYRRQTEL-QDKSEFSDVDKLAFKDNEEF-ESSFESAGNMPRQLEMGG 842
+ S + L ++ EL Q K E + A + ++ F + + +
Sbjct: 837 FSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQ 896
Query: 843 LSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREER---RQS 899
A +S ++ + L +Q +I+E K+ + E +KE + E +
Sbjct: 897 NVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKK 956
Query: 900 NLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLE 959
+ ++ +RE+E+L QE ++ E+ L + KS N ++
Sbjct: 957 EMSSIISLNKREIEELTQENGTLK-----------EINASLNQEKMNLIQKSESFANYID 1005
Query: 960 KYMKIIQQEQDQESADK 976
+ K I + DQ +K
Sbjct: 1006 EREKSISELSDQYKQEK 1022
Score = 55.8 bits (133), Expect = 2e-07
Identities = 171/908 (18%), Positives = 358/908 (39%), Gaps = 144/908 (15%)
Query: 145 KELAEYHQAKESCNMETQT-SSTFNRDSLAEKLQLIDD----QFADAYPQRIKFESLEIK 199
+EL + + E N + + + +R+ + + + ++D +F D + + S +
Sbjct: 1854 QELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKAS 1913
Query: 200 LNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEA 259
+ +E L +KL KD E K + E+EL++ ++ Q + E
Sbjct: 1914 IEHEALYLEADLEVVQTEKLCLEKDNEN---KQKVIVCLEEELSVVTSERN---QLRGEL 1967
Query: 260 LVLREKST-LERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFE-----LN 313
+ +K+T L+++ + + +T+E+ + + L + + EAE+K++ E + ++
Sbjct: 1968 DTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVA---EAEVKEKTELLQTLSSDVS 2024
Query: 314 QKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTN-----RL 368
+ L+++ H + E L+ E++ ++ T +L+N++ QL + + +++ + RL
Sbjct: 2025 ELLKDKTH--LQEKLQSLEKDSQALSLT-KCELENQIA--QLNKEKELLVKESESLQARL 2079
Query: 369 IED--ERKNKEKA-----VHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAIT 421
E E+ N KA V E + ++S +EE++Q +++L + +E+ + + L I
Sbjct: 2080 SESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIA 2139
Query: 422 KQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAV 481
EK+KE +N LK ++E NL ++++ EL +
Sbjct: 2140 -------EKLKERE-------------RENDSLKDKVE-----NLERELQMSEENQELVI 2174
Query: 482 FQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVAD 541
E KAE + L Q+++ + ++ ++ ++LT Q+ +
Sbjct: 2175 LDAENSKAEV-------------ETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQE 2221
Query: 542 LKLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLA 601
+ QL + L + +S+++ I + + + + L N K+ N
Sbjct: 2222 KQGQLSELDKLLSSF------KSLLEEKEQAEIQ---IKEESKTAVEMLQNQLKELNEAV 2272
Query: 602 RMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSA 661
+ D E + T+ + +E +L + R+ +
Sbjct: 2273 AALCG-----------------DQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEK 2315
Query: 662 KSPLAAKS-PPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGS 720
K + S H + K + ER + + + LE N E T
Sbjct: 2316 KQLCVLQQLKESEHHADLLKGRVENL-EREL----EIARTNQEHAALEAENSKGEVETLK 2370
Query: 721 AASRLRGGTSSRR---LSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTE 777
A ++ G T S R L + K +L +E+ E S + + + + E
Sbjct: 2371 A--KIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQE 2428
Query: 778 SRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDV---DKLAFKDNEEFESSFESAGNM 834
V + + QT+L++ +E D+ A K E+ SS +
Sbjct: 2429 K--------VQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLEL 2480
Query: 835 PRQLEMGGLSPAGD-----MSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKE 889
+ + GL A + S V+ V Q ++I K + + +EQ V +
Sbjct: 2481 EKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSK 2540
Query: 890 RRQREERRQSNLQEVLERER------RELEKLYQERKMIEESLKIKIKKELEMENELE-- 941
Q E Q ++ LE ++++ L + ++++L++ +ENELE
Sbjct: 2541 LSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELT 2600
Query: 942 ----MSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQ----S 993
MS E +K E L++ M + Q+ + + S +K G L L+ S
Sbjct: 2601 KMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSS 2660
Query: 994 SDKVESLT 1001
D+++ LT
Sbjct: 2661 KDQLKELT 2668
Score = 50.1 bits (118), Expect = 1e-05
Identities = 145/806 (17%), Positives = 302/806 (37%), Gaps = 130/806 (16%)
Query: 248 DFEKACQAKSEALV-LREKSTLERIHKHQEIETKE--IYAQRQLL--LKDMDLLRGREAE 302
+ E C+ ++L L EK + I K++EI+ E + ++RQ L L+ L + +
Sbjct: 1551 ELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQ 1610
Query: 303 LKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYI 362
K E+ KL EK ++T L+ E+ + QL+ D
Sbjct: 1611 QKLTSVTLEMESKLAAEK------------------KQTEQLSLELEVARLQLQGLD--- 1649
Query: 363 IRTNRLI----EDERKNKEKAVHLQEELIAINSK---KEELNQSVNRVKELELELESVKA 415
+ + L+ ED + + ++ + +E + ++ K +++Q ++ + +L L+ K
Sbjct: 1650 LSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKI 1709
Query: 416 QSLAITKQNHMLNEKVKEMSDYSLLKEEK----------LELLAQNKL------------ 453
K + + ++Y E+K L N L
Sbjct: 1710 TETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDI 1769
Query: 454 --LKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQL 511
L+ +++E+ NENLRLL+ V + RK E +++ E +E +S QL
Sbjct: 1770 HNLQLRVKETSNENLRLLH----------VIEDRDRKVE-SLLNEMKELDSKLHLQEVQL 1818
Query: 512 QDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSV-IDRSV 570
+IE +L+ + K L+ ++ ++ +E N + D+S
Sbjct: 1819 MTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSS 1878
Query: 571 NGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRIT-NYPTAWVEGSSPDSDLEFVA 629
I NV N FL+ EN L+R+ + + + + ++E +DLE V
Sbjct: 1879 REDIGDNVAKVNDSWKERFLD----VENELSRIRSEKASIEHEALYLE-----ADLEVVQ 1929
Query: 630 NTKARVKELQQEAERLEKAFRSYHRRVI--KNSAKSPLAAKSPPSLHLLEAFKNITSSSP 687
K +++ + +++ V +N + L S + L + + + +
Sbjct: 1930 TEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQ 1989
Query: 688 ERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLE 747
E + + Q ++E+ ++++ L+ + L+ T L + +SLE
Sbjct: 1990 ELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLK--------DKTHLQEKLQSLE 2041
Query: 748 SEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDK 807
+ L + + + ++ ++K L + LQ +
Sbjct: 2042 KDSQALSLTKCELENQ-----------------------IAQLNKEKELLVKESESLQAR 2078
Query: 808 SEFSDVDKL--------AFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAV 859
SD +KL A + EF S QL G + + A
Sbjct: 2079 LSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRG-------IEKLRVRIEAD 2131
Query: 860 PLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQER 919
H + K+ E + + K + + ++ Q E Q + E + E+E L +
Sbjct: 2132 EKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQI 2191
Query: 920 KMIEESLKIKIKKELEMENELEMSNQEIKDKS---AHSENPLEKYMKIIQQEQDQESADK 976
+ + SLK+ + + +E E ++I++K + + L + ++++++ E K
Sbjct: 2192 EEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIK 2251
Query: 977 SSKKMVQEGSLVDTLQSSDKVESLTG 1002
K E + ++ V +L G
Sbjct: 2252 EESKTAVEMLQNQLKELNEAVAALCG 2277
Score = 48.5 bits (114), Expect = 3e-05
Identities = 71/356 (19%), Positives = 155/356 (43%), Gaps = 35/356 (9%)
Query: 131 SDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQ----LIDDQFADA 186
S+KEN + + H L+ + Q K E + +R++L+ +++ ++D + +
Sbjct: 635 SEKENLQSKINH-LETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEV 693
Query: 187 YPQRIKFESLEIKLN----EYKREIEEQLRAEMCQKLKFF----KDTE----IAKIKMEA 234
Q++ + L+ K ++++EIE MC K +D E + ++
Sbjct: 694 ETQKLAYMELQQKAEFSDQKHQKEIEN-----MCLKTSQLTGQVEDLEHKLQLLSNEIMD 748
Query: 235 KKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMD 294
K + ++L ++K +LV E + Q+ +A ++ +
Sbjct: 749 KDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFAN---IIGEQG 805
Query: 295 LLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQ 354
+ +E + + N + + + S+ +L Q+Q ++ + EL++ +
Sbjct: 806 SMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCE-----ELVQIK 860
Query: 355 LELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAI-NSKKEELNQSVNRVKELEL---EL 410
E++++ + + ++ LQE+ A N E L+ N+ KEL+L ++
Sbjct: 861 GEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKV 920
Query: 411 ESVKAQSLAITKQNHMLNEKVKEMSDYS-LLKEEKLELLAQNKLLKQQLEESRNEN 465
E+ +A+ + K NH+L + +KE+ S L EK E+ + L K+++EE EN
Sbjct: 921 ETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQEN 976
Score = 44.7 bits (104), Expect = 5e-04
Identities = 170/907 (18%), Positives = 362/907 (39%), Gaps = 100/907 (11%)
Query: 144 LKELAE-YHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKF----ESLEI 198
L+ L E Y Q+ E + ++ + E QL+ + + R ++ E +
Sbjct: 1552 LESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQ 1611
Query: 199 KLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSE 258
KL E+E +L AE Q + + E+A+++++ + L D E A Q ++E
Sbjct: 1612 KLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGI--DTEDAIQGRNE 1669
Query: 259 ALVLREK---STLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREA-----ELKQRVEAF 310
+ + ++ T ER KH + + AQ+ L L D++ + A E
Sbjct: 1670 SCDISKEHTSETTERTPKHDVHQICDKDAQQDLNL-DIEKITETGAVKPTGECSGEQSPD 1728
Query: 311 ELNQKLQEEKHKSITEALRRQEQN----------IKSFEETYDRKLK-----NELLKYQL 355
+ E+K + +E + + + + E+ ++ +L+ NE L+ L
Sbjct: 1729 TNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRL-L 1787
Query: 356 ELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKE---ELNQSVNRVK----ELEL 408
+ +D + L+ +E K + +HLQE + + +K E EL + V +K +L
Sbjct: 1788 HVIEDRDRKVESLL-NEMKELDSKLHLQE--VQLMTKIEACIELEKIVGELKKENSDLSE 1844
Query: 409 ELESVKA---QSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNEN 465
+LE + L + + LN ++ +D S ++ + N K++ + NE
Sbjct: 1845 KLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENEL 1904
Query: 466 LRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQI 525
R+ + A E + +L + + ++ E+ +Q + L++E+ + Q+
Sbjct: 1905 SRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNEN-KQKVIVCLEEELSVVTSERNQL 1963
Query: 526 LGYKASVKSLTTQVADLKLQLKQTQTALENE----VYCNPKQSVIDRSVNGLINGNVVPC 581
G ++ TT + L ++K+ LE+ ++C + L+
Sbjct: 1964 RGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQ----TL 2019
Query: 582 NGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQE 641
+ ++S + QE + + S+ + +E + E + VKE +
Sbjct: 2020 SSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKE----KELLVKESESL 2075
Query: 642 AERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNI------TSSSPERHIFGED 695
RL ++ Y + + + ++ L K +L L + + R E
Sbjct: 2076 QARLSES--DYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEK 2133
Query: 696 RVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLES-EMYLEG 754
+ + ++ E ND ++ + L+ ++ L +K +E+ + +E
Sbjct: 2134 KQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEE 2193
Query: 755 LGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQD--KSEFSD 812
+ RS D + L S E+ ++ ++K G +L KS +
Sbjct: 2194 MARSLKVFEL---DLVTLRSEKEN--------LTKQIQEKQGQLSELDKLLSSFKSLLEE 2242
Query: 813 VDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAV--PLSYQHP---S 867
++ + EE +++ E N ++L + GD + A ++ P+ +H S
Sbjct: 2243 KEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNS 2302
Query: 868 VD--QKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIE-- 923
++ + ++E ++++ QQ+KE + + + E LERE E+ + QE +E
Sbjct: 2303 IEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRV-ENLERE-LEIARTNQEHAALEAE 2360
Query: 924 ------ESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKS 977
E+LK KI+ + LE+ I+ + + N L+K + I + E + S
Sbjct: 2361 NSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERI---SELEIINSS 2417
Query: 978 SKKMVQE 984
+ ++QE
Sbjct: 2418 FENILQE 2424
Score = 38.9 bits (89), Expect = 0.025
Identities = 74/449 (16%), Positives = 175/449 (38%), Gaps = 24/449 (5%)
Query: 116 KINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEK 175
K++ T K+L+S + + ++ LKE +S N + T +++L K
Sbjct: 587 KLSKTEKESKALLSALELKKKE---YEELKEEKTLFSCWKSENEKLLTQMESEKENLQSK 643
Query: 176 LQLIDDQF------ADAYPQRIKF-----ESLEIKLNEYKREIEEQLRAEMCQKLKFFKD 224
+ ++ + Y +R++ E+L +++ ++ + QKL + +
Sbjct: 644 INHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMEL 703
Query: 225 TEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYA 284
+ A+ + +K + + + + + L L +++ +Q++ + Y
Sbjct: 704 QQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAE--YE 761
Query: 285 QRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDR 344
+ LLK D + ++ + AF+ + I E + + E
Sbjct: 762 SLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQS 821
Query: 345 KLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSV---- 400
+ +L+ +++ + + ++ D +K E+ V ++ E+ K E+++QS
Sbjct: 822 PKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAET 881
Query: 401 -NRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLE 459
R+ +L+ E A + + L K KE+ + E + + + K LE
Sbjct: 882 SQRISKLQ---EDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLE 938
Query: 460 ESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSA 519
+S E L L+ E++ ++ + + E+ + +L+++ + I+ S
Sbjct: 939 DSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSE 998
Query: 520 QLKAQILGYKASVKSLTTQVADLKLQLKQ 548
I + S+ L+ Q KL L Q
Sbjct: 999 SFANYIDEREKSISELSDQYKQEKLILLQ 1027
Score = 37.0 bits (84), Expect = 0.094
Identities = 33/121 (27%), Positives = 66/121 (54%), Gaps = 5/121 (4%)
Query: 302 ELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDY 361
EL+ +++ + ++ ++ + S+ AL++Q+Q +++ E+T LK E + +E+ +
Sbjct: 22 ELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVEN-EKTEGTNLKRENQRL-MEICES- 78
Query: 362 IIRTNRLIEDERKNKEKAVHLQEELIAINSKK-EELNQSVNRVKELELELESVKAQSLAI 420
+ +T + I E + KE V+ QE + K+ E+L Q + R K ELE AQS +
Sbjct: 79 LEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKS-ELERSQQAAQSADV 137
Query: 421 T 421
+
Sbjct: 138 S 138
Score = 34.3 bits (77), Expect = 0.61
Identities = 30/143 (20%), Positives = 69/143 (48%), Gaps = 18/143 (12%)
Query: 864 QHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIE 923
Q+ K +++ +K+ E +R+ E R S Q++ E+E+ E+L ++++ +
Sbjct: 349 QYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQ 408
Query: 924 E------SLKIKIKKELE----MENELEMSNQEIKDKSAHSENPLEKY-MKIIQQEQDQE 972
+K ++ +EL+ M N L+ ++ EN LE++ K+ + EQ +
Sbjct: 409 TLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQ 468
Query: 973 SAD-------KSSKKMVQEGSLV 988
++ +S ++M +E +L+
Sbjct: 469 ASQIKENELRRSMEEMKKENNLL 491
Score = 33.5 bits (75), Expect = 1.0
Identities = 34/140 (24%), Positives = 68/140 (48%), Gaps = 8/140 (5%)
Query: 874 EEQKEEEKIREQQVKERRQREERRQSNLQ---EVLERERRELEKLYQERKMIEESLKIKI 930
+EQ E + +++++ Q + + ++LQ EVL+ + LE + KM + S K+
Sbjct: 2552 KEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKV 2611
Query: 931 KKELEMENELEMSNQEIKDKSAHSENPLE-KYMKIIQQEQDQESADKSSKKMVQEGSLVD 989
K E EL+ E+ K+A + L + ++ + Q KSSK ++E
Sbjct: 2612 NKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKE----L 2667
Query: 990 TLQSSDKVESLTGFSHEELD 1009
TL++S+ +SL ++++
Sbjct: 2668 TLENSELKKSLDCMHKDQVE 2687
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 77.8 bits (190), Expect = 5e-14
Identities = 102/452 (22%), Positives = 207/452 (45%), Gaps = 67/452 (14%)
Query: 144 LKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEY 203
LK+ E+ +AK+S ++ L +LQ ++ + IK E
Sbjct: 1550 LKQFKEHRKAKDSALQSIESKML----ELTNRLQESQEEI-----------QIMIKEKEE 1594
Query: 204 KREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYE-KELTMFQNDFEKACQAKSEALVL 262
+ ++E L+ E Q + K+ +AK+K +K+Y+ ++T EK C+ + L
Sbjct: 1595 MKRVQEALQIERDQLKENTKEI-VAKMKESQEKEYQFLKMTAVNETQEKMCEIEH----L 1649
Query: 263 REKSTLERIHKHQEIETKEIYAQRQL---------LLKDMDLLRGREAELKQRVEAFELN 313
+E+ ++++ + IET+ I + L + K+ D LR E LK VE +L
Sbjct: 1650 KEQFETQKLNL-ENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLK--VERDQLK 1706
Query: 314 QKLQEEKHKSITEALRRQEQ------NIKSFEETYDR------KLKNELLKYQ--LELKD 359
+ L+E +IT L +QE+ ++K +ET D+ + NE+ Q LE +
Sbjct: 1707 ENLRE----TITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSN 1762
Query: 360 DYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKA---Q 416
D + + I++E + +HL+E+ I+ + +++ +++ ++ +LE+ A +
Sbjct: 1763 DALKAQDLKIQEELRIAH--MHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQE 1820
Query: 417 SLAITKQN-HMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQP 475
+ K N H L K++++ E +L Q K L + ENL L +L +
Sbjct: 1821 KIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHEN 1880
Query: 476 APELAVFQKE---LRKAEKAIVVEHEEFESCRQ---ALHKQLQDEIEHSAQL----KAQI 525
E+ KE LR+ E+ + +E ++ + Q A ++Q E++ + L K +
Sbjct: 1881 LEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETV 1940
Query: 526 LGYKASVKSLTTQVADLKLQLKQTQTALENEV 557
+ + T Q++D++ L +++ L+ ++
Sbjct: 1941 DKLREKISEKTIQISDIQKDLDKSKDELQKKI 1972
Score = 73.2 bits (178), Expect = 1e-12
Identities = 107/489 (21%), Positives = 213/489 (43%), Gaps = 87/489 (17%)
Query: 140 LMHFLKELAEYHQAKESCNMETQTSSTFNRDSLA----------EKLQLIDDQFADAYPQ 189
L+ +KE++E + + T+ S+T + +LA EK Q ++ +
Sbjct: 1291 LLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKE 1350
Query: 190 RIKF----ESLEIKLNEYKREIEEQL--------RAEMCQKLKFFKDTEIAKIKMEAKKK 237
R E+LE+K ++ K I E L + E +K KD E KI E ++
Sbjct: 1351 RDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKE-KDNETTKIVSEMEQF 1409
Query: 238 YEKELTMFQNDFE-----KACQAKSEAL--VLREKSTLERIHKHQEIETKEIYAQ-RQLL 289
K+ + + + E K Q + + V +EK L+R+ + + E+ ++ ++++
Sbjct: 1410 KPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIV 1469
Query: 290 LKDMDL---LRGREAELKQRVEAF-ELNQKLQEEKHK---------SITEALRRQEQNIK 336
K ++ L+ LK++ E EL L E++ + +I + L+ + Q I
Sbjct: 1470 AKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIY 1529
Query: 337 SFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVH-LQEELIAINSKKEE 395
EE ++ K +E+ + ELK ++ RK K+ A+ ++ +++ + ++
Sbjct: 1530 EKEEQFNIKQISEVQEKVNELKQ---------FKEHRKAKDSALQSIESKMLELTNR--- 1577
Query: 396 LNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEM---------SDYSLLK----E 442
L +S ++ + E E +K A+ + L E KE+ +Y LK
Sbjct: 1578 LQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVN 1637
Query: 443 EKLELLAQNKLLKQQ-------LEESRNENLRLLNRLAQPAPELAVFQKE---LRKAEKA 492
E E + + + LK+Q LE EN+RL L + E+ KE LR E+
Sbjct: 1638 ETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEET 1697
Query: 493 IVVEHEEF-ESCRQALHKQLQDEIE------HSAQLKAQILGYKASVKSLTTQVADLKLQ 545
+ VE ++ E+ R+ + + L+ + E H + + I + V T ++++++
Sbjct: 1698 LKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKD 1757
Query: 546 LKQTQTALE 554
L+ + AL+
Sbjct: 1758 LEHSNDALK 1766
Score = 70.5 bits (171), Expect = 8e-12
Identities = 219/1048 (20%), Positives = 417/1048 (39%), Gaps = 162/1048 (15%)
Query: 17 DELRKKLYQTFKDRGILDTLKTQLRNQLIHELMHPVLSGELQPRSISVEGSSLLIGASNS 76
+ LRK++ ++ I+ + K +L ++++H+ + G L+ I L SN
Sbjct: 757 ERLRKEIQDKSEELHIITSEKDKLFSEVVHKESR--VQGLLE--EIGKTKDDLATTQSNY 812
Query: 77 LVADH------LQRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSG 130
D +E + E+ +++ + Q K + + K+ +S
Sbjct: 813 KSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQ--KFDSSLGALKTELSY 870
Query: 131 SDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDS--LAEKLQLIDDQFADAYP 188
+E Q+ + L E Q KE T T R+ + EKLQ ++
Sbjct: 871 KTQELQEK-TREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQ 929
Query: 189 QRIKF----ESLEIKLNEYKREI----------EEQLRAEMCQKLKFFKDTEIAKIKMEA 234
++ ESL+I+ ++ K +I +EQLR + + LK ++T I +K +
Sbjct: 930 EKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNAL-ESLKQHQET-INTLKSKI 987
Query: 235 KKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMD 294
++ + L M +N E + + + + + +K LE K+ + T ++ KD +
Sbjct: 988 SEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEA--KNTQTLTADV--------KDNE 1037
Query: 295 LLRGREAELKQRVEAFELNQKLQE---EKHKSITEALRRQEQNIKSFEETYDRKLKNELL 351
++ + E EL Q L+ EK + T+ E I++ EE +L + L
Sbjct: 1038 IIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEEL---RLLGDEL 1094
Query: 352 KYQLEL----------KDDYIIRT-NRLIEDERKNKEKAVHLQEELIAINSKKEELNQSV 400
K Q E+ K+ + RT +RL E E K KEK+ LQE+ + + +EE+++
Sbjct: 1095 KKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQ 1154
Query: 401 NRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLK--QQL 458
++ E+E +K + L + HM E+++ + EE + + K+LK Q+
Sbjct: 1155 KKINEIENLKNELKNKELTL---EHMETERLELAQKLNENYEEVKSITKERKVLKELQKS 1211
Query: 459 EESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQAL--HKQLQDEIE 516
E+ ++LR +R+ E + EE + L H++ DE+
Sbjct: 1212 FETERDHLR----------------GYIREIEATGLQTKEELKIAHIHLKEHQETIDELR 1255
Query: 517 HSAQLK-AQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQ-SVIDRSVNGLI 574
S K AQI+ + KS T KLQ + E E+ N K+ S ++N L
Sbjct: 1256 RSVSEKTAQIINTQDLEKSHT------KLQEEIPVLHEEQELLPNVKEVSETQETMNEL- 1308
Query: 575 NGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKAR 634
E+ + + K LAR+ R+ + +S E + TK R
Sbjct: 1309 ---------ELLTE--QSTTKDSTTLARIEMERLR------LNEKFQESQEEIKSLTKER 1351
Query: 635 --VKELQQEAERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIF 692
+K +++ E + + R + +S +K SL++ E T
Sbjct: 1352 DNLKTIKEALEVKHDQLKEHIRETLAKIQES--QSKQEQSLNMKEKDNETT--------- 1400
Query: 693 GEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGG---TSSRRLSSTPLPKAKRSLESE 749
++VSE Q + +E + RL+ S L + + L+SE
Sbjct: 1401 ---KIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSE 1457
Query: 750 M-YLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQ--D 806
L+ + +A + + + H + E +V L ++TE+
Sbjct: 1458 SDQLKENIKEIVAKHLETEEELKV------AHCCLKEQEETINELRVNLSEKETEISTIQ 1511
Query: 807 KSEFSDVDKLAFKDNEEFE----------SSFESAGNMPRQLEMGGLSPAGDMSHVDAAA 856
K + DKL K E +E S + N +Q + + + +++
Sbjct: 1512 KQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKM 1571
Query: 857 AAVPLSYQHPSVDQKQIEEQKEE-EKIREQQVKERRQREERRQSNLQEVLERERRELEKL 915
+ Q + + + ++KEE ++++E ER Q +E N +E++ + + EK
Sbjct: 1572 LELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKE----NTKEIVAKMKESQEKE 1627
Query: 916 YQERKMI------EESLKIKIKKELEMENELEMSN---QEIKDKSAHSENPLEKYMKIIQ 966
YQ KM E+ +I+ KE +L + N + I+ EN LE+ + +
Sbjct: 1628 YQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHEN-LEEMRSVTK 1686
Query: 967 QEQDQESADKSSKKMVQEGSLVDTLQSS 994
+ D S +++ K V+ L + L+ +
Sbjct: 1687 ERDDLRSVEETLK--VERDQLKENLRET 1712
Score = 66.6 bits (161), Expect = 1e-10
Identities = 211/1093 (19%), Positives = 431/1093 (39%), Gaps = 153/1093 (13%)
Query: 15 SQDELRKKLYQTFKDRGILDTLKTQLRNQLIHELMHPVLSGE----LQPRSISVEGSSLL 70
+Q++LR L + + ++TLK+++ ++ L +GE Q + + ++ L
Sbjct: 962 TQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDL 1021
Query: 71 IGASN-SLVADHLQRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLI--KINPTSSLYKSL 127
+ +L AD E +F L +EK Q L +I K + L +++
Sbjct: 1022 EAKNTQTLTADVKDNEIIEQQRKIF----SLIQEKNELQQMLESVIAEKEQLKTDLKENI 1077
Query: 128 VSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAY 187
+ + + L LK+ E +++ ++ + + D LAE + + ++
Sbjct: 1078 EMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQ 1137
Query: 188 PQRIKFESLEIKLNEYKREIEE--QLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMF 245
++ + +++ +++E +++I E L+ E+ K + E ++++ K
Sbjct: 1138 EKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQK---------L 1188
Query: 246 QNDFEKACQAKSEALVLRE-KSTLERIHKH-----QEIETKEIYAQRQLLLKDMDLLRGR 299
++E+ E VL+E + + E H +EIE + + +L + + L +
Sbjct: 1189 NENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQ 1248
Query: 300 EA--ELKQRVE---AFELNQKLQEEKHKSITEALR--RQEQ----NIKSFEETYDRKLKN 348
E EL++ V A +N + E+ H + E + +EQ N+K ET + +
Sbjct: 1249 ETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNEL 1308
Query: 349 ELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELEL 408
ELL Q KD + ++ E + +N K +E S +K L
Sbjct: 1309 ELLTEQSTTKDSTTL----------------ARIEMERLRLNEKFQE---SQEEIKSLTK 1349
Query: 409 ELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRL 468
E +++K A+ ++ L E ++E +L K ++ + + L ++E NE ++
Sbjct: 1350 ERDNLKTIKEALEVKHDQLKEHIRE----TLAKIQESQSKQEQSL---NMKEKDNETTKI 1402
Query: 469 LNRLAQPAPE---LAVFQKELRKAEKAIVVEHEEFESCR------QALHKQLQDEIEHSA 519
++ + Q P+ L + E+ K + H+E +S Q L + LQ E S
Sbjct: 1403 VSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSE---SD 1459
Query: 520 QLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVV 579
QLK I A ++ LK+ + + NE+ N + + S I +
Sbjct: 1460 QLKENIKEIVAKHLETEEELKVAHCCLKEQEETI-NELRVNLSEKETEIST---IQKQLE 1515
Query: 580 PCNGEISGDFLNNPFKQENVLARMVAS---RITNYPTAWVEGSSPDSDLEFVANTKA--- 633
N ++ K+E + ++ ++ + DS L+ + +
Sbjct: 1516 AINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELT 1575
Query: 634 -RVKELQQEAE----------RLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNI 682
R++E Q+E + R+++A + R +K + K + AK S F +
Sbjct: 1576 NRLQESQEEIQIMIKEKEEMKRVQEALQ-IERDQLKENTKE-IVAKMKESQEKEYQFLKM 1633
Query: 683 TSSSPERHIFGEDRVVSEQPQVGTL-----EERNDVVEALTGSAASRLRGGTSSR----- 732
T+ + + E + EQ + L E N + + +R T R
Sbjct: 1634 TAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRS 1693
Query: 733 ----------RLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMP--LPSPTESRH 780
+L R LE + L+ + H+ D++ + T
Sbjct: 1694 VEETLKVERDQLKENLRETITRDLEKQEELK-IVHMHLKEHQETIDKLRGIVSEKTNEIS 1752
Query: 781 SLSIPPVSSPPEQKVGLYRRQTELQD-----KSEFSDVDKLAFKDNEEFESSFESAGNMP 835
++ S K + Q EL+ K + +DKL +E+ + NM
Sbjct: 1753 NMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDK----LSNMQ 1808
Query: 836 RQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEK-IREQQVK------ 888
+ LE + + A + + + QK++ E ++ +K I++Q +
Sbjct: 1809 KDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEI 1868
Query: 889 ERRQREERRQSNLQEVL----ERE--RRELEKLYQERKMIEESLKIKIKKELEMENELEM 942
E ++ NL+E+ ER+ RR E L ER ++ESL+ ++LE++ EL+
Sbjct: 1869 ENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKT 1928
Query: 943 SNQEIKDKSAHSENPLEKYM-KIIQQEQDQESADKSSKKMVQEGSLVDTLQSSD----KV 997
+ K+ + EK K IQ Q+ DKS ++ ++ + LQ + +V
Sbjct: 1929 ARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKK---IQELQKKELQLLRV 1985
Query: 998 ESLTGFSHEELDD 1010
+ SH+++++
Sbjct: 1986 KEDVNMSHKKINE 1998
Score = 63.2 bits (152), Expect = 1e-09
Identities = 89/420 (21%), Positives = 185/420 (44%), Gaps = 51/420 (12%)
Query: 131 SDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQR 190
S+K N+ + + K+L + A ++ +++ Q L E+ + ID +
Sbjct: 1745 SEKTNE---ISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKT 1801
Query: 191 IKFESLEIKLNEYKREIEE---QLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQN 247
K +++ L +++E +L+A Q + KD + K+ ++ +K++
Sbjct: 1802 DKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQI----- 1856
Query: 248 DFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRV 307
K ++L L K +E ++ Q++ E + + ++K+ D LR E LK +
Sbjct: 1857 --------KDQSLTL-SKLEIENLNLAQKLH--ENLEEMKSVMKERDNLRRVEETLK--L 1903
Query: 308 EAFELNQKLQEEKHKS--ITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRT 365
E +L + LQE K + I + L+ K +ET D KL+ ++ + +++ D
Sbjct: 1904 ERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVD-KLREKISEKTIQISDIQ---- 1958
Query: 366 NRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELE----------LELESVKA 415
L + + + ++K LQ++ + + KE++N S ++ E+E L ++SV+
Sbjct: 1959 KDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRM 2018
Query: 416 QSLAITKQNHMLNEKV----KEMSDYSLLKEE-KLELLAQNKLLKQQLEESR-NENLRLL 469
+ +TK+ H E++ KE + +KE K+E L++ + R N ++
Sbjct: 2019 DNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPE 2078
Query: 470 NRLAQPAPE-LAVFQKELRKAEKAIVVEHEEFE---SCRQALHKQLQDEIEHSAQLKAQI 525
RL + L +E K ++ + E + C L L+ EIE +L ++
Sbjct: 2079 KRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRV 2138
Score = 56.2 bits (134), Expect = 1e-07
Identities = 91/478 (19%), Positives = 206/478 (43%), Gaps = 50/478 (10%)
Query: 107 TMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSST 166
+ + L ++ T+ K+ ++ + L + KE+ + + E ++ET+ +
Sbjct: 312 SFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQA- 370
Query: 167 FNRDSLAEKLQLIDDQFADAYPQRIKFESL-EIKLNEYKREIEEQLRAEMCQKLKFFKDT 225
+D LA QL++++ Q K E+L + + ++++L+A+ +++ +
Sbjct: 371 MEKDQLA---QLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLG- 426
Query: 226 EIAKIKME------------AKKKYEKELTMFQNDFEKACQAKS------EALVLREKST 267
+I K+K K ++ + + + E C + L E +
Sbjct: 427 KINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNP 486
Query: 268 LERIHKHQEIETK--EIYAQRQLLLKDMDLLRGREAEL------KQRVEAFE-LNQKLQE 318
++ + IE++ + A L+ D + LR + E+ K ++ FE L +K ++
Sbjct: 487 ATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKK 546
Query: 319 EKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLEL---KDDYIIRTNRLIEDERKN 375
++ + + + N+ E Y++ L+NEL ++EL K+D I + I+ ++
Sbjct: 547 DQEMQLIHEISNLK-NLVKHAEVYNQDLENELSS-KVELLREKEDQIKKLQEYIDSQKLE 604
Query: 376 KEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMS 435
K + L L +I K+ + Q++ + + L+ K +S + +N L EK+KE++
Sbjct: 605 NIK-MDLSYSLESIEDPKQ-MKQTLFDAETVALD---AKRESAFLRSENLELKEKMKELA 659
Query: 436 DYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVV 495
E ++ L + QLE + + L L E+ + ++
Sbjct: 660 TTYKQMENDIQ------LYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLL 713
Query: 496 EHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTAL 553
+ E E L K+L E+E + L+ +++ + +KSL ++V L+ +++ L
Sbjct: 714 CNLELEGKITDLQKELNKEVEENEALREEVI-LLSELKSLPSEVERLRKEIQDKSEEL 770
Score = 49.3 bits (116), Expect = 2e-05
Identities = 160/870 (18%), Positives = 338/870 (38%), Gaps = 115/870 (13%)
Query: 238 YEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLR 297
+++ LT Q F + + E ST E + K E ++ Q + + +
Sbjct: 313 FDETLTALQ--FASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQA 370
Query: 298 GREAELKQRVEAFELNQKLQEEKHKSITEALRRQ-----EQNIKSFEETYD-------RK 345
+ +L Q +E +L QK+Q EK +++T L +Q +K+ + K
Sbjct: 371 MEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINK 430
Query: 346 LKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIA--INSKKE-ELNQSVNR 402
+KN Q + + +T++L + + +++V + ++ + +++ E E N +
Sbjct: 431 MKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKL 490
Query: 403 VKE--LELELESVKA---------QSLAITKQNHMLNEKVK-EMSDYSLL-----KEEKL 445
+ + +E EL S++A + L K+ L K K ++ ++ L K++++
Sbjct: 491 LNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEM 550
Query: 446 ELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQ 505
+L+ + LK ++ + N L N L+ L + +++K ++ I + ++ E+ +
Sbjct: 551 QLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYI--DSQKLENIKM 608
Query: 506 ALHKQLQDEIEHSAQLKAQI-------LGYKASVKSLTTQVADLKLQLKQTQTA---LEN 555
L L+ IE Q+K + L K L ++ +LK ++K+ T +EN
Sbjct: 609 DLSYSLES-IEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMEN 667
Query: 556 EVYCNPKQSVIDRSVNGLINGNVVPCNGEISG--DFLNNPFKQENVLARMVASRITNYPT 613
++ Q + + + + EI+ ++ ++ + + +IT+
Sbjct: 668 DIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQK 727
Query: 614 AWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAF--RSYHRRVI---KNSAKSPLAAK 668
+ + L + +K L E ERL K +S +I K+ S + K
Sbjct: 728 ELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHK 787
Query: 669 SPPSLHLLEAF-----------KNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEAL 717
LLE N S+ E F + EQ LEE + + +
Sbjct: 788 ESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEI 847
Query: 718 TGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTE 777
+ + +S L + K + E ++ +R E
Sbjct: 848 VNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVE 907
Query: 778 SRHSL-------SIPPVSSPPEQKVGLYRRQTELQD-----KSEFSDVDKLAFKDNEEFE 825
+L ++ V + ++K L + Q LQ KS+ D + E+
Sbjct: 908 REKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLR 967
Query: 826 SSFESAGNMPRQLEMGGLSPAGDMS---HVDAAAAAVPLSYQHPSV--DQKQIEEQKEEE 880
++ ES + + ++S H++ +Q V D+KQ E K +
Sbjct: 968 NALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQ 1027
Query: 881 KIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEM---- 936
+ VK+ E++R+ L +E+ EL+++ + +E LK +K+ +EM
Sbjct: 1028 TLTAD-VKDNEIIEQQRKIFS---LIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIEN 1083
Query: 937 ENELEMSNQEIK------------------------DKSAHSENPLEKYMKIIQQEQDQ- 971
+ EL + E+K D+ A E L++ + +Q++Q Q
Sbjct: 1084 QEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQL 1143
Query: 972 ESADKSSKKMVQEGSLVDTLQSSDKVESLT 1001
+ + +M ++ + ++ L++ K + LT
Sbjct: 1144 LNVQEEMSEMQKKINEIENLKNELKNKELT 1173
Score = 47.4 bits (111), Expect = 7e-05
Identities = 90/440 (20%), Positives = 180/440 (40%), Gaps = 80/440 (18%)
Query: 124 YKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQF 183
Y + + E+ F M F+ E+ + + Q +R+ KL +Q
Sbjct: 2179 YVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKL----NQN 2234
Query: 184 ADAYPQRIKFESLEIKLNEYKREIEEQL--RAEMCQKLKFFKDT--EIAKIKMEAKKKYE 239
D + + I + E + K E ++ L R EM Q L+ + +T +I K+K +K+ +
Sbjct: 2235 MDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKEND 2294
Query: 240 KELTMFQNDFEKACQA-KSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRG 298
+ + N F A +E+ E+S I K E + K + + + L K+ L+
Sbjct: 2295 R-ICQVNNFFNNRIIAIMNESTEFEERSAT--ISKEWEQDLKSLKEKNEKLFKNYQTLKT 2351
Query: 299 REAELKQRVEAFELNQKLQEEKHKSIT--------EALRRQEQNIKSFEETYDRKLKNEL 350
A Q +N Q+ K+ +T E +R E ++ +E+ K ++++
Sbjct: 2352 SLASGAQ------VNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHK-ESKI 2404
Query: 351 LKYQ--LELKDDYIIRTNRLIEDERKNKEKA---VHLQEELIAINSK--KEELN------ 397
+K Q LE+ +D I + + + K EK + + ++ +A+ +K KEE+
Sbjct: 2405 IKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKL 2464
Query: 398 -----QSVNRVKELELELESVKA------QSLAITKQNHMLNEKVKEMSDYS-------- 438
+ + KE E E+ + KA + + + ++N +++ ++ S S
Sbjct: 2465 VKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPS 2524
Query: 439 -------------------LLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPEL 479
+LK E + L + LKQQ E+ + LL+ + E+
Sbjct: 2525 NKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEV 2584
Query: 480 AVFQKEL--RKAEKAIVVEH 497
+++ R+A K + E+
Sbjct: 2585 KTWKERTLKREAHKQVTCEN 2604
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 77.4 bits (189), Expect = 6e-14
Identities = 178/915 (19%), Positives = 380/915 (41%), Gaps = 140/915 (15%)
Query: 115 IKINPTSSLY---KSLVSGSDKENQKGFLMHF---LKELAEYHQAKESCNMETQTSSTFN 168
+K P LY K L+ +++E + + LKE E +A+ E S
Sbjct: 824 VKNWPWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQE 883
Query: 169 RDSLAEKLQLIDDQFADAYPQ-------RIKFESLEIKLNEYKREIEEQLRAEMCQKLKF 221
++ L ++Q D ADA + +I+ E+ ++NE + E EE++ AE+ K +
Sbjct: 884 KNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNE-RLEDEEEMNAELTAKKRK 942
Query: 222 FKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKE 281
+D E +++K + + ELT+ + + EK + E + L+ I E K
Sbjct: 943 LED-ECSELKRDID---DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKA 998
Query: 282 IYAQRQLLLKDM-------DLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQN 334
+ Q L D+ + L + +L+Q+V+ E + + +++ + A R+ E +
Sbjct: 999 LQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGD 1058
Query: 335 IKSFEETY-DRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSK- 392
+K +E+ D + + L +L+ KD + N IEDE+ A+ S+
Sbjct: 1059 LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQ--------------ALGSQL 1104
Query: 393 KEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNK 452
+++L + R++ELE ELE+ + + K L+ +++E+S E+LE
Sbjct: 1105 QKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEIS-------ERLEEAGGAT 1157
Query: 453 LLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALH---- 508
++ ++ + R A FQK R E+A ++HE + + H
Sbjct: 1158 SVQIEMNKKRE----------------AEFQKMRRDLEEA-TLQHEATAAALRKKHADSV 1200
Query: 509 KQLQDEIEHSAQLKAQILGYKASVK-------SLTTQVADLKLQLKQTQTALENEV-YCN 560
+L ++I++ ++K ++ K+ K S Q+ K L++ LE+++
Sbjct: 1201 AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHR 1260
Query: 561 PKQSVIDRSVNGLIN--GNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEG 618
K RSVN L + + NGE+S ++E +++++ ++T
Sbjct: 1261 SKAEETQRSVNDLTSQRAKLQTENGELSRQL----DEKEALISQLTRGKLTY-------- 1308
Query: 619 SSPDSDLEFVANTKARVKELQQEAERLEKAFRS--YHRRVIKNSAKSPLAAKSPPSLHLL 676
+ + + K +++E + L A +S + +++ + AK+ L
Sbjct: 1309 ------TQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLS 1362
Query: 677 EAFKNI----TSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSR 732
+A + T + E+ +++ L+E + VEA+ +S
Sbjct: 1363 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSS--------- 1413
Query: 733 RLSSTPLPKAKRSLESEM--YLEGLGRSHIASPSPCPDRM---PLPSPTESRHSLSIPPV 787
L K K L++E+ + + RS+ A+ + + + + + ++ S +
Sbjct: 1414 ------LEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSEL 1467
Query: 788 SSPPEQKVGLYRRQTELQDKSE--------FSDVDKLAFKDNEEFESSFESAGNMPRQLE 839
S ++ L +L++ E F +K ++ + S+G +LE
Sbjct: 1468 ESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELE 1527
Query: 840 MGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIR---EQQVKERRQREER 896
+ + +A S +H + K + Q E +I+ E+++ E+ + E+
Sbjct: 1528 KVRKQLEAEKMELQSALEEAEASLEHE--EGKILRAQLEFNQIKAEIERKLAEKDEEMEQ 1585
Query: 897 RQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSEN 956
+ N V++ + L+ E + E+L++K K E ++ NE+E+ +A ++
Sbjct: 1586 AKRNHLRVVDSLQTSLD---AETRSRNEALRVKKKMEGDL-NEMEIQLSHANRMAAEAQK 1641
Query: 957 PLEKYMKIIQQEQDQ 971
++ +++ Q Q
Sbjct: 1642 QVKSLQSLLKDTQIQ 1656
Score = 76.3 bits (186), Expect = 1e-13
Identities = 163/804 (20%), Positives = 319/804 (39%), Gaps = 120/804 (14%)
Query: 189 QRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDT-EIAKIKMEAKKKYEKELTMFQN 247
+R+K + E+ + E E+ L +++ +KLK + E + ++EA++ ++ ++
Sbjct: 1078 ERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRS 1137
Query: 248 DFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRV 307
D + + SE L +T +I +++ E A+ Q + +D++ EA L+
Sbjct: 1138 DLSRELEEISERLEEAGGATSVQIEMNKKRE-----AEFQKMRRDLE-----EATLQHEA 1187
Query: 308 EAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNR 367
A L +K H L Q N++ ++ KL+ E +++LEL DD +
Sbjct: 1188 TAAALRKK-----HADSVAELGEQIDNLQRVKQ----KLEKEKSEFKLEL-DDVTSNMEQ 1237
Query: 368 LIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHML 427
+I+ + ++ L++++ SK EE +SVN + +L++ + + L
Sbjct: 1238 IIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGEL------SRQL 1291
Query: 428 NEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELR 487
+EK +S L KL Q + LK+QLEE L + L + + +++
Sbjct: 1292 DEKEALISQ---LTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQ-- 1346
Query: 488 KAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLK 547
+EE + L + L AQ + + Y+ T ++ + K +L
Sbjct: 1347 ---------YEEETEAKAELQRVLSKANSEVAQWRTK---YETDAIQRTEELEEAKKKLA 1394
Query: 548 QTQTALENEVYC-NPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVAS 606
Q E V N K S ++++ + L Q + MV
Sbjct: 1395 QRLQEAEEAVEAVNAKCSSLEKTKHRL----------------------QNEIEDLMVDV 1432
Query: 607 RITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKSPLA 666
+N A ++ + D + +A K + +E Q E E +K RS + K L
Sbjct: 1433 ERSNAAAAALDKKQRNFD-KILAEWKQKYEESQSELESSQKEARSLSTELFK------LK 1485
Query: 667 AKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLR 726
SL LE FK + E E +D+ E L
Sbjct: 1486 NAYEESLEHLETFKRENKNLQE--------------------EISDLTEQL--------- 1516
Query: 727 GGTSSRRLSSTPLPKAKRSLESE-MYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIP 785
G+S + + L K ++ LE+E M L+ AS ++ R L
Sbjct: 1517 -GSSGKTIHE--LEKVRKQLEAEKMELQSALEEAEASLEHEEGKI-------LRAQLEFN 1566
Query: 786 PVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSP 845
+ + E+K+ + E ++ VD L + E S E+ + +++E
Sbjct: 1567 QIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEAL-RVKKKMEGDLNEM 1625
Query: 846 AGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVL 905
+SH + AA + K + Q ++ +KE ERR + LQ L
Sbjct: 1626 EIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAEL 1685
Query: 906 ERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKII 965
E R +E+ + RK+ E+ L I+ + +++ L N + ++ + L + +
Sbjct: 1686 EELRAVVEQTERSRKLAEQEL-IETSERVQL---LHSQNTSLINQKKKMDADLSQLQTEV 1741
Query: 966 QQE-QDQESADKSSKKMVQEGSLV 988
++ Q+ +A++ +KK + + +++
Sbjct: 1742 EEAVQECRNAEEKAKKAITDAAMM 1765
Score = 53.1 bits (126), Expect = 1e-06
Identities = 95/454 (20%), Positives = 184/454 (40%), Gaps = 79/454 (17%)
Query: 131 SDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLA-EKLQLIDDQFADAYPQ 189
SD Q G + EL + + E+ ME Q++ SL E+ +++ Q
Sbjct: 1510 SDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEF---N 1566
Query: 190 RIKFESLEIKLNEYKREIEE----QLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMF 245
+IK E +E KL E E+E+ LR + +T + KKK E +L
Sbjct: 1567 QIKAE-IERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEM 1625
Query: 246 QNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDM-------DLLRG 298
+ A + +EA ++ +L+ + K +I+ + L +++ +LL+
Sbjct: 1626 EIQLSHANRMAAEAQ--KQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA 1683
Query: 299 REAELKQRVEAFELNQKLQEEKHKSITEALRR-QEQNIKSFEETYDRKLKNELLKYQLEL 357
EL+ VE E ++KL E++ +E ++ QN + +K+ +L + Q E+
Sbjct: 1684 ELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQK--KKMDADLSQLQTEV 1741
Query: 358 KDDY-------------IIRTNRLIEDERKNKEKAVHLQE-------------------E 385
++ I + E+ +K ++ + HL+ E
Sbjct: 1742 EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAE 1801
Query: 386 LIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKL 445
IA+ K++L + RV+ELE ELE+ + ++ K ++KE
Sbjct: 1802 QIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKE------------ 1849
Query: 446 ELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQ 505
L Q EE R LRL + + + ++ ++++ +AE+ +F +
Sbjct: 1850 --------LTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQH 1901
Query: 506 ALHKQLQDEIEHSAQL-KAQILGYKASVKSLTTQ 538
L DE E A + ++Q+ +A + + T+
Sbjct: 1902 EL-----DEAEERADIAESQVNKLRAKSRDIGTK 1930
Score = 52.4 bits (124), Expect = 2e-06
Identities = 166/867 (19%), Positives = 324/867 (37%), Gaps = 127/867 (14%)
Query: 180 DDQFADAYPQRIKF-ESLEIKLNEYK-REIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKK 237
+ QF D+ K SL+I N+YK + +A + L+ +D +++I + +
Sbjct: 732 EGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQ 791
Query: 238 YEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLK------ 291
L + ++K + + LV++ + + ++Y + + LLK
Sbjct: 792 SRGVLARME--YKKLLERRDSLLVIQWN--IRAFMGVKNWPWMKLYFKIKPLLKSAEREK 847
Query: 292 DMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEA-------LRRQEQNIKSFEETYDR 344
+M ++ LK+ +E E +K EEK S+ + ++ ++ N+ EE D+
Sbjct: 848 EMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQ 907
Query: 345 KLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNR-V 403
+KN K QLE K + N +EDE + + EL A K E+ + R +
Sbjct: 908 LIKN---KIQLEAK---VKEMNERLEDEEE-------MNAELTAKKRKLEDECSELKRDI 954
Query: 404 KELELELESVKAQSLAITKQNHMLNEKVKEMSDY--SLLKEEK-LELLAQNKLLKQQLEE 460
+LEL L V+ + A + L E++ + + L KE+K L+ Q L Q EE
Sbjct: 955 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEE 1014
Query: 461 SRNENLRLLN-RLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSA 519
+ L +L Q +L ++ +K + + E + + + D
Sbjct: 1015 DKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQ 1074
Query: 520 QLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVV 579
QL ++ + +L ++ D + Q Q L+ E+ ++ + V
Sbjct: 1075 QLDERLKKKDFELNALNARIEDEQALGSQLQKKLK-ELQARIEELEEELEAERTARAKVE 1133
Query: 580 PCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQ 639
++S + E + R+ + G + +E +A ++++
Sbjct: 1134 KLRSDLSREL-------EEISERLEEA-----------GGATSVQIEMNKKREAEFQKMR 1175
Query: 640 QEAERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVS 699
++ E + + K A S A+ + L+ K D V S
Sbjct: 1176 RDLEEATLQHEATAAALRKKHADS--VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTS 1233
Query: 700 EQPQV-----------GTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSL-E 747
Q+ TLE++ + + + TS R T + R L E
Sbjct: 1234 NMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDE 1293
Query: 748 SEMYLEGLGRSHIASPSPCPD-RMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQD 806
E + L R + D + L +++++L+ LQ
Sbjct: 1294 KEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALA------------------HALQ- 1334
Query: 807 KSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHP 866
S D D L E++E E+ + R L S ++ A Y+
Sbjct: 1335 -SARHDCDLL----REQYEEETEAKAELQRVL-----------SKANSEVAQWRTKYETD 1378
Query: 867 SVDQ-KQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLY--------- 916
++ + +++EE K++ R Q+ +E + + S+L++ R + E+E L
Sbjct: 1379 AIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA 1438
Query: 917 -----QERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQ 971
++++ ++ L +K E ++ELE S +E + S L K ++ +
Sbjct: 1439 AAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTE----LFKLKNAYEESLEH 1494
Query: 972 ESADKSSKKMVQE--GSLVDTLQSSDK 996
K K +QE L + L SS K
Sbjct: 1495 LETFKRENKNLQEEISDLTEQLGSSGK 1521
Score = 48.9 bits (115), Expect = 2e-05
Identities = 93/432 (21%), Positives = 191/432 (44%), Gaps = 61/432 (14%)
Query: 170 DSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAK 229
++ AE +++ ++ R K+E+ I+ E E +++L A+ Q+ + + AK
Sbjct: 1352 EAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKL-AQRLQEAEEAVEAVNAK 1410
Query: 230 IKMEAKKKY--EKELTMFQNDFEKACQAKSEALVLREKS----TLERIHKHQEIETKEIY 283
K K+ + E+ D E++ A + AL ++++ E K++E +++
Sbjct: 1411 CSSLEKTKHRLQNEIEDLMVDVERS-NAAAAALDKKQRNFDKILAEWKQKYEESQSELES 1469
Query: 284 AQRQLLLKDMDLLRGREA--ELKQRVEAFELNQKLQEEKHKSITE--------------- 326
+Q++ +L + + A E + +E F+ K +E+ +TE
Sbjct: 1470 SQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKV 1529
Query: 327 --ALRRQEQNIKSFEETYDRKLKNE---LLKYQLELKDDYIIRTNRLIE-DERKNKEKAV 380
L ++ ++S E + L++E +L+ QLE +L E DE + K
Sbjct: 1530 RKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRN 1589
Query: 381 HLQ---EELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEM-SD 436
HL+ +++++ N+++ K++E +L ++ Q ++ N M E K++ S
Sbjct: 1590 HLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQ---LSHANRMAAEAQKQVKSL 1646
Query: 437 YSLLKEEKLEL---LAQNKLLKQQLE--ESRN-------ENLRLLNRLAQPAPELAVFQK 484
SLLK+ +++L + N LK+ + E RN E LR + + + +LA ++
Sbjct: 1647 QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLA--EQ 1704
Query: 485 ELRKAEKAIVVEHEEFESCRQALHK------QLQDEIEHSAQLKAQILGYKASVKSLTTQ 538
EL + + + + H + S K QLQ E+E + Q + + K T
Sbjct: 1705 ELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ---ECRNAEEKAKKAITD 1761
Query: 539 VADLKLQLKQTQ 550
A + +LK+ Q
Sbjct: 1762 AAMMAEELKKEQ 1773
Score = 35.0 bits (79), Expect = 0.36
Identities = 42/222 (18%), Positives = 97/222 (43%), Gaps = 22/222 (9%)
Query: 792 EQKVGLYRRQTELQD-----KSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPA 846
E L ++ +L+D K + D++ K +E ++ N+ EM GL
Sbjct: 931 EMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTE--EMAGLDEI 988
Query: 847 GDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLE 906
++ + A+ ++Q ++D Q EE K + + + + E++ +L+ LE
Sbjct: 989 --IAKLTKEKKALQEAHQQ-ALDDLQAEEDKVNT------LTKAKVKLEQQVDDLEGSLE 1039
Query: 907 RERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQ 966
+E++ L + ++ +E LK+ + +++EN+ + ++ +K K E +
Sbjct: 1040 QEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKD------FELNALNAR 1093
Query: 967 QEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEEL 1008
E +Q + KK+ + + ++ L+ + E E+L
Sbjct: 1094 IEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKL 1135
Score = 32.3 bits (72), Expect = 2.3
Identities = 25/113 (22%), Positives = 58/113 (51%), Gaps = 9/113 (7%)
Query: 895 ERRQSNLQEVLERERRELEKLYQERKMIEESL--KIKIKKELEMENELEMSN----QEIK 948
E+ ++++E R + LEK RK +EE + ++ K +L+++ + E N +E
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERC 905
Query: 949 DKSAHSENPLEKYMKIIQ---QEQDQESADKSSKKMVQEGSLVDTLQSSDKVE 998
D+ ++ LE +K + +++++ +A+ ++KK E + + D +E
Sbjct: 906 DQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLE 958
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 77.4 bits (189), Expect = 6e-14
Identities = 108/476 (22%), Positives = 199/476 (41%), Gaps = 56/476 (11%)
Query: 124 YKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQF 183
Y+ + SD EN +G + K E + K+ + T+ L E ++I+ Q
Sbjct: 87 YQEGLKDSDLENSEGLSRVYSKLYKEAEKIKK-WKVSTEAELRQKESKLQENRKIIEAQR 145
Query: 184 ADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQK--LKFFKDTEIAKIKMEAKKKYEKE 241
+ E + +KL E +E ++ ++ + K+T + K +YE+E
Sbjct: 146 KAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYERE 205
Query: 242 LTM-----FQNDFEKACQAKSEALVLREKSTLERIHK----HQEIETKEIYAQRQLLLKD 292
T N+ EK A E V E S LE K +++I+ E ++++ K+
Sbjct: 206 ETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKE 265
Query: 293 MD----LLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIK-SFEETYDRKLK 347
L++ E E K + F L + +K + E + Q +N+K S E+ + +
Sbjct: 266 KQVSLLLIQITEKENKMKDLTFLLEES--RDKVNQLEEKTKLQSENLKQSIEKQHHLTKE 323
Query: 348 NELLKYQLE--------LKDDYIIRTN---RLIED-----ERKNKEKAVHL--------- 382
E +K L+ L++D I T +L E+ E NK +A H
Sbjct: 324 LEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETT 383
Query: 383 ---QEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSL 439
EEL+ ++ E N+ +++K L +EL+ ++ +TK + N K E+ +
Sbjct: 384 VCSLEELLRTEQQRLEKNE--DQLKILTMELQKKSSELEEMTK---LTNNKEVELEELKK 438
Query: 440 LKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEE 499
+ EK LL +NK ++ EE + L+ L E+ + +L AI +
Sbjct: 439 VLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQL----TAITTSEQY 494
Query: 500 FESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALEN 555
+ + L +L++E + +L + K LT + +D+ L+LK Q + N
Sbjct: 495 YSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINN 550
Score = 68.2 bits (165), Expect = 4e-11
Identities = 97/426 (22%), Positives = 184/426 (43%), Gaps = 71/426 (16%)
Query: 154 KESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREI------ 207
K+S +E T T N++ E+L+ + + + +FE + +L ++E+
Sbjct: 414 KKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQA 473
Query: 208 --------EEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEA 259
E QL A + + K+ + K ++E +K ELT N K E
Sbjct: 474 REKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCN---KLSLENKEL 530
Query: 260 LVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAF--ELNQKLQ 317
TLE ++ ++I + Q + +LK ++ L+ E +L+ +E EL QK
Sbjct: 531 TQETSDMTLELKNQQEDINNNK--KQEERMLKQIENLQETETQLRNELEYVREELKQKRD 588
Query: 318 EEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKE 377
E K K L + E+N + L+ Q+E K+ YI L ++ + K+
Sbjct: 589 EVKCK-----LDKSEENCNN-------------LRKQVENKNKYI---EELQQENKALKK 627
Query: 378 KAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDY 437
K ++ ++LN +V +LELELES K + IT + KE+ D
Sbjct: 628 KGT----------AESKQLNVYEIKVNKLELELESAKQKFGEIT------DTYQKEIEDK 671
Query: 438 SLLKEEKLELLAQNKLLKQQLEESRNE-NLRLLNRLAQPAPELAVFQKELRKAEKAIVVE 496
+ +E LE + + K++ + + + E + R +++A+ +A+ +K + +K I
Sbjct: 672 KISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAE---MVALMEKHKHQYDKIIEER 728
Query: 497 HEEF------ESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQ 550
E E + +L L+ E+ + LKA++L K ++ + LK + K+
Sbjct: 729 DSELGLYKSKEQEQSSLRASLEIEL---SNLKAELLSVKKQLEIEREEKEKLKREAKENT 785
Query: 551 TALENE 556
L+ +
Sbjct: 786 ATLKEK 791
Score = 57.8 bits (138), Expect = 5e-08
Identities = 111/550 (20%), Positives = 218/550 (39%), Gaps = 96/550 (17%)
Query: 207 IEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKS 266
+EE LR E + K +I ++++ K +E+T N+ K + + VL EK
Sbjct: 387 LEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNN--KEVELEELKKVLGEKE 444
Query: 267 TLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITE 326
TL ++++++ E K + L+G E EL ++A E E + +IT
Sbjct: 445 TL--LYENKQFE------------KIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITT 490
Query: 327 ALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEEL 386
+ + + +K + +L+NE LK + N+L +NKE +
Sbjct: 491 SEQYYSKEVKDLKT----ELENEKLK-----NTELTSHCNKL---SLENKELTQETSDMT 538
Query: 387 IAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLE 446
+ + +++E++N + + + + ++E+++ + + + E++K+ D K +K E
Sbjct: 539 LELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSE 598
Query: 447 -----LLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFE 501
L Q + + +EE + EN L + + +L V++ ++ K E + ++F
Sbjct: 599 ENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFG 658
Query: 502 SCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNP 561
K+++D+ K S ++L +V K+ + L+ E
Sbjct: 659 EITDTYQKEIEDK--------------KISEENLLEEVEKAKV-IADEAVKLQKE----- 698
Query: 562 KQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSP 621
ID+ I V + Q + + S + Y + E SS
Sbjct: 699 ----IDKRCQHKIAEMVA---------LMEKHKHQYDKIIEERDSELGLYKSKEQEQSSL 745
Query: 622 DSDLEF-VANTKARV----KELQQEAERLEKAFRSYHRRVI----KNSAKSPLAAKSPPS 672
+ LE ++N KA + K+L+ E E EK R K K+ P
Sbjct: 746 RASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPE 805
Query: 673 LHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSR 732
++ K + S + R+ D +S+ ++ D + TS++
Sbjct: 806 IYWKLDSKAVPSQTVSRNFTSVDHGISK--------DKRDYL-------------WTSAK 844
Query: 733 RLSSTPLPKA 742
STPLPKA
Sbjct: 845 NTLSTPLPKA 854
Score = 45.1 bits (105), Expect = 3e-04
Identities = 37/137 (27%), Positives = 69/137 (50%), Gaps = 22/137 (16%)
Query: 870 QKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEES---- 925
+ ++E +EE K + +VK + + E +NL++ +E + + +E+L QE K +++
Sbjct: 573 RNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAE 632
Query: 926 ------LKIKIKK-ELEMENE-------LEMSNQEIKDKSAHSENPLEKY--MKIIQQE- 968
+IK+ K ELE+E+ + +EI+DK EN LE+ K+I E
Sbjct: 633 SKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEA 692
Query: 969 -QDQESADKSSKKMVQE 984
+ Q+ DK + + E
Sbjct: 693 VKLQKEIDKRCQHKIAE 709
Score = 43.5 bits (101), Expect = 0.001
Identities = 52/244 (21%), Positives = 101/244 (41%), Gaps = 58/244 (23%)
Query: 800 RQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSH-VDAAAAA 858
++ EL++ + + +N++FE E ++L +G L H ++ A
Sbjct: 429 KEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQEL-IGLLQAREKEVHDLEIQLTA 487
Query: 859 VPLSYQHPSVDQKQIEEQKEEEKIR--------------------------------EQQ 886
+ S Q+ S + K ++ + E EK++ ++
Sbjct: 488 ITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQED 547
Query: 887 VKERRQREER---RQSNLQEVLERERRELEKLYQERKMIEESLKIK----------IKKE 933
+ +++EER + NLQE + R ELE + +E K + +K K ++K+
Sbjct: 548 INNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQ 607
Query: 934 LEMEN----ELEMSNQEIKDKSAHSENPLEKY-MKIIQQEQDQESADKSSKKMVQEGSLV 988
+E +N EL+ N+ +K K L Y +K+ + E + ESA + + G +
Sbjct: 608 VENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQ------KFGEIT 661
Query: 989 DTLQ 992
DT Q
Sbjct: 662 DTYQ 665
Score = 38.1 bits (87), Expect = 0.042
Identities = 30/126 (23%), Positives = 66/126 (52%), Gaps = 10/126 (7%)
Query: 870 QKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIK 929
+K+I +++++ + Q+ E+ E + +L +LE R ++ +L ++ K+ E+LK
Sbjct: 258 KKEINDKEKQVSLLLIQITEK----ENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQS 313
Query: 930 IKKELEMENELEMSNQEIKDKSAHSENPLEKYMK-----IIQQEQDQESADKSSKKMVQE 984
I+K+ + ELE ++ +S ++ LE+ ++ I Q +++E+ + S K
Sbjct: 314 IEKQHHLTKELEDIKVSLQ-RSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAA 372
Query: 985 GSLVDT 990
S V T
Sbjct: 373 HSFVVT 378
Score = 34.3 bits (77), Expect = 0.61
Identities = 38/169 (22%), Positives = 72/169 (42%), Gaps = 34/169 (20%)
Query: 851 HVDAAAAAVPLSYQHPSVDQKQIEEQ------------KEEEKIREQQVKERRQRE---- 894
H+ + +S Q QK +EE +E+E E+ K R
Sbjct: 319 HLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVT 378
Query: 895 --ERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSA 952
E +L+E+L E++ LEK + K++ L+ KK E+E +++N
Sbjct: 379 EFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQ---KKSSELEEMTKLTN-------- 427
Query: 953 HSENPLEKYMKIIQQEQDQESADKSSKKMVQ-----EGSLVDTLQSSDK 996
+ E LE+ K++ +++ +K +K+ + E L+ LQ+ +K
Sbjct: 428 NKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREK 476
Score = 32.0 bits (71), Expect = 3.0
Identities = 31/90 (34%), Positives = 41/90 (45%), Gaps = 10/90 (11%)
Query: 856 AAAVPLSYQHPSVDQKQIEEQKEE---EKIREQQVKERRQREERRQSNL-------QEVL 905
A V L +H K IEE+ E K +EQ+ R E SNL ++ L
Sbjct: 708 AEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQL 767
Query: 906 ERERRELEKLYQERKMIEESLKIKIKKELE 935
E ER E EKL +E K +LK K K+ +
Sbjct: 768 EIEREEKEKLKREAKENTATLKEKKDKKTQ 797
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 75.9 bits (185), Expect = 2e-13
Identities = 153/784 (19%), Positives = 315/784 (40%), Gaps = 109/784 (13%)
Query: 280 KEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQE--EKHKSITEALRRQEQNIKS 337
K A++++ D R +E + EL +K+ ++ + ++ + +N+
Sbjct: 845 KSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMD 904
Query: 338 FEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKE----------KAVHLQEEL- 386
EE + +K+++L LE K + T RL E+E N E K L+ ++
Sbjct: 905 AEERCEGLIKSKIL---LEAKVKEL--TERLEEEEEMNSELVAKKRNLEDKCSSLKRDID 959
Query: 387 ---IAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEE 443
+ + ++E + + N+VK L E+ +++ +TK+ L E ++ D ++E+
Sbjct: 960 DLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEED 1019
Query: 444 KLE-LLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHE---E 499
K+ L+ N L+QQ ++ L L Q A ++ RK E + + E +
Sbjct: 1020 KVNGLIKINAKLEQQTDD-------LEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMD 1072
Query: 500 FESCRQALHKQLQDEIEHSAQLKAQI-------LGYKASVKSLTTQVADLKLQLKQTQTA 552
E+ +Q + ++L+ + +QL+A+I L ++ +K L ++ +L+ +++ T
Sbjct: 1073 LENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTL 1132
Query: 553 LENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYP 612
++S + R + I+ + +G S N K+E +M R
Sbjct: 1133 ---RAKIEKQRSDLARELEE-ISERLEEASGATSAQIEMNK-KREAEFQKM--RRDLEEA 1185
Query: 613 TAWVEGSSP---DSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKSPLAAKS 669
T E ++ + VA ++ LQ+ ++LEK + ++ +KS
Sbjct: 1186 TLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKS 1245
Query: 670 PPSLH-----LLEAFKNITSSSPERHIFGEDRVVSE---QPQVGTLEERNDVVEALTGSA 721
++ + + F I + ++ D + + Q Q G L R + E+L
Sbjct: 1246 KSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQL 1305
Query: 722 ASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHS 781
T S++ + L + KR +E E + + S D + E
Sbjct: 1306 -------TKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAK 1358
Query: 782 LSIPPVSSPPEQKVGLYRRQTE---LQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQL 838
+ S +V +R + E +Q E + K + +E E + E+A + L
Sbjct: 1359 AELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASL 1418
Query: 839 EMGGLSPAG-------DMSHVDAAAAAVP---------LSYQHPSVDQKQIE---EQKEE 879
E G D+ A A + L+ +D+ Q E QKE
Sbjct: 1419 EKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKES 1478
Query: 880 EKIREQQVKERRQREERRQSNLQEVLERERREL--------EKLYQERKMIEESLKIKIK 931
+ + K R EE + E L RE + L E++ + K ++E+ K K
Sbjct: 1479 RSLSTELFKMRNAYEE--VVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKL 1536
Query: 932 KELEMENELEMSNQEIKDKSAHSENPL------------EKYMKIIQQEQDQESADKSSK 979
E E +++L+++ +E++ H E+ + E K+I+++++ E ++S+
Sbjct: 1537 VEQE-KSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQ 1595
Query: 980 KMVQ 983
+ +
Sbjct: 1596 RAAE 1599
Score = 72.8 bits (177), Expect = 2e-12
Identities = 166/862 (19%), Positives = 351/862 (40%), Gaps = 82/862 (9%)
Query: 202 EYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALV 261
+++R EE R+E +K K + + K + + + + E D E+ C+ ++ +
Sbjct: 859 DFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLM-DAEERCEGLIKSKI 917
Query: 262 LRE---KSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQE 318
L E K ER+ + +E+ ++ + +R L K L R + +L+ + E + E
Sbjct: 918 LLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDID-DLELTLTKVEKEKHATE 976
Query: 319 EKHKSITEALRRQEQNI-------KSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIED 371
K K+++E + E+NI KS +E + + L + ++ E K + +I+ N +E
Sbjct: 977 NKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVE---EDKVNGLIKINAKLEQ 1033
Query: 372 ERKNKEKAVHLQEELIA-INSKKEELNQSVNRVKELELELESVKAQSLAITKQNHM---- 426
+ + E ++ +++L A + K +L + +E ++LE+ K Q K+
Sbjct: 1034 QTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQ 1093
Query: 427 LNEKVKEMSDYSLLKEEKL-ELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKE 485
L K+ + +SL ++K+ EL A+ + L++++E ++ + + A EL +
Sbjct: 1094 LQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISER 1153
Query: 486 LRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQ 545
L +A A + E + K +D E + Q +A + ++ +
Sbjct: 1154 LEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDN 1213
Query: 546 LKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVA 605
L++ + LE E + + ID + + + N E + + + F +
Sbjct: 1214 LQRVKQKLEKEK--SELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQT 1271
Query: 606 SRITNYPTAWVEGSSPDSDLEF-VANTKARVKELQQEAERLEKAFRSYHRRVIKNS-AKS 663
I + + + +L V ++ + +L + + L + R++ + + AK+
Sbjct: 1272 QLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKN 1331
Query: 664 PLAAKSPPSLH----LLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEE-----RNDVV 714
+A S H L E ++ + E + SE Q T E R + +
Sbjct: 1332 AMAHALQSSRHDCDLLREQYEEEQEAKAELQR-ALSKANSEVAQWRTKYETDAIQRTEEL 1390
Query: 715 EALTGSAASRLRGG---TSSRRLSSTPLPKAKRSLESEM--YLEGLGRSHIASPSPCPDR 769
E A RL+ T + L K K+ L+ E+ + L RSH A
Sbjct: 1391 EEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACA------ 1444
Query: 770 MPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFE 829
T + + V + +QK+ + + E K S +L FK +E +
Sbjct: 1445 ------TLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTEL-FKMRNAYEEVVD 1497
Query: 830 SAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKE 889
+ R+ + + ++S + A + Q +K +E++K + ++ ++V+
Sbjct: 1498 QLETLRRENK----NLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEG 1553
Query: 890 RRQREERRQSNLQ------------EVLERERRELEKLYQERKMIEESLKIKIKKELEME 937
+ EE + +Q +V+E++ E+E+L + + E+L+ + E+
Sbjct: 1554 SLEHEESKILRVQLELSQVKSELDRKVIEKDE-EIEQLKRNSQRAAEALQSVLDAEIRSR 1612
Query: 938 NE-------LEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEG--SLV 988
N+ +E E++ + HS + + K ++ Q Q K S+ + + S
Sbjct: 1613 NDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQL---KDSQLHLDDALRSNE 1669
Query: 989 DTLQSSDKVESLTGFSHEELDD 1010
D + VE G EEL++
Sbjct: 1670 DLKEQLAIVERRNGLLLEELEE 1691
Score = 70.1 bits (170), Expect = 1e-11
Identities = 101/466 (21%), Positives = 191/466 (40%), Gaps = 74/466 (15%)
Query: 114 LIKINPTSSLYKSLVSGS---------DKENQKGFLMHFLKELAEYHQAKESCNMETQTS 164
LIKIN + GS D E K L LK E E+ + +
Sbjct: 1024 LIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEK 1083
Query: 165 STFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIE---------EQLRAEM 215
L++ IDD+ + + K + L+ ++ E + EIE E+ R+++
Sbjct: 1084 LKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDL 1143
Query: 216 CQKLKFFKD-----TEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLER 270
++L+ + + ++E KK E E + D E+A L+ ++T
Sbjct: 1144 ARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEA--------TLQHEATAAT 1195
Query: 271 IHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRR 330
+ K Q E+ Q L + L ++ELK ++ N EAL +
Sbjct: 1196 LRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASN-----------IEALSK 1244
Query: 331 QEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAIN 390
+ NI+ T + + +++ KD+ + +LI D N +KA +
Sbjct: 1245 SKSNIERTCRTVEDQFS------EIKAKDE---QQTQLIHD--LNMQKA--------RLQ 1285
Query: 391 SKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQ 450
++ EL+ +RV+E E + + A+T+Q L E ++M + + K L
Sbjct: 1286 TQNGELS---HRVEEKESLISQLTKSKQALTQQ---LEELKRQMEEETKAKNAMAHALQS 1339
Query: 451 NK----LLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQA 506
++ LL++Q EE + L L++ E+A ++ K E + EE E ++
Sbjct: 1340 SRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWR---TKYETDAIQRTEELEEAKKK 1396
Query: 507 LHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTA 552
L ++LQ+ E++ ++ + + + L +V DL L+++ TA
Sbjct: 1397 LAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTA 1442
Score = 67.4 bits (163), Expect = 6e-11
Identities = 158/827 (19%), Positives = 335/827 (40%), Gaps = 108/827 (13%)
Query: 196 LEIKLNEY--KREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKAC 253
LE K+ E + E EE++ +E+ K + +D + + +K + + ELT+ + + EK
Sbjct: 919 LEAKVKELTERLEEEEEMNSELVAKKRNLED-KCSSLKRDID---DLELTLTKVEKEKHA 974
Query: 254 QAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELN 313
+ E + LE E K + Q L D+ + + L ++N
Sbjct: 975 TENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGL------IKIN 1028
Query: 314 QKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDER 373
KL+++ E QE+ +++ E RKL+ +L Q + D + + IE++
Sbjct: 1029 AKLEQQTDD--LEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMD--LENDKQQIEEKL 1084
Query: 374 KNKEKAVH-----LQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLN 428
K KE + + +E + ++++ + R++ELE E+E+ I KQ L
Sbjct: 1085 KKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLA 1144
Query: 429 EKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRK 488
+++E+S+ L+E AQ ++ K++ E + L Q A +K+
Sbjct: 1145 RELEEISE--RLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQAD 1202
Query: 489 AEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQ 548
+ + + + + +Q L K+ ++LK +I +++++L+ ++++ +
Sbjct: 1203 SVAELGEQIDNLQRVKQKLEKE-------KSELKMEIDDMASNIEALSKSKSNIERTCRT 1255
Query: 549 TQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRI 608
+ + +Q+ + +N + + NGE+S + ++E++++++ S+
Sbjct: 1256 VEDQFSEIKAKDEQQTQLIHDLN-MQKARLQTQNGELS----HRVEEKESLISQLTKSK- 1309
Query: 609 TNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKSPLAAK 668
+ L Q+ E L++ + AK+ +A
Sbjct: 1310 ---------------------------QALTQQLEELKRQMEE------ETKAKNAMAHA 1336
Query: 669 SPPSLH----LLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEE-----RNDVVEALTG 719
S H L E ++ + E + SE Q T E R + +E
Sbjct: 1337 LQSSRHDCDLLREQYEEEQEAKAELQ-RALSKANSEVAQWRTKYETDAIQRTEELEEAKK 1395
Query: 720 SAASRLR---GGTSSRRLSSTPLPKAKRSLESEM--YLEGLGRSHIASPSPCPDRMPLPS 774
A RL+ T + L K K+ L+ E+ + L RSH A
Sbjct: 1396 KLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTA------------C 1443
Query: 775 PTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNM 834
T + + V + +QK+ + + E K S +L FK +E + +
Sbjct: 1444 ATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTEL-FKMRNAYEEVVDQLETL 1502
Query: 835 PRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQRE 894
R+ + ++S + A + Q +K +E++K + ++ ++V+ + E
Sbjct: 1503 RRE----NKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHE 1558
Query: 895 ERRQSNLQEVLERERRELEKLYQERKMIEESLKI-KIKKELEMENELEMSNQEIKDKSAH 953
E + +Q L + + EL +RK+IE+ +I ++K+ + E S + + +S +
Sbjct: 1559 ESKILRVQLELSQVKSEL-----DRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRN 1613
Query: 954 SENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESL 1000
L+K M+ E + + S+++M + + T+Q K L
Sbjct: 1614 DALRLKKKMEGDLNEMEIQ-LGHSNRQMAETQKHLRTVQGQLKDSQL 1659
Score = 62.8 bits (151), Expect = 2e-09
Identities = 100/484 (20%), Positives = 197/484 (40%), Gaps = 99/484 (20%)
Query: 141 MHFLKELAEYHQAKESCNMETQTSSTFN------RDSLAEKLQLIDDQFADAYPQRIKFE 194
+ F K++ E E E + T R LA +L+ I ++ +A
Sbjct: 1106 LQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGAT---- 1161
Query: 195 SLEIKLNEYKREIE-EQLRAEMCQKLKFFKDTEIAKIKMEA----------------KKK 237
S +I++N+ KRE E +++R ++ + + T K +A K+K
Sbjct: 1162 SAQIEMNK-KREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQK 1220
Query: 238 YEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYA---QRQLLLKDMD 294
EKE + + + + A + + + KS +ER + E + EI A Q+ L+ D++
Sbjct: 1221 LEKEKSELKMEIDD--MASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLN 1278
Query: 295 LLRGR----EAELKQRVEAFE------------LNQKLQEEKHK---------SITEALR 329
+ + R EL RVE E L Q+L+E K + ++ AL+
Sbjct: 1279 MQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQ 1338
Query: 330 RQEQNIKSFEETYDR-------------KLKNELLKYQLELKDDYIIRTNRLIEDERKNK 376
+ E Y+ K +E+ +++ + + D I RT L E ++K
Sbjct: 1339 SSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1398
Query: 377 EKAVHLQEELIAINSKKEELNQSVNR----VKELELELESVKAQSLAITKQNHMLNEKVK 432
++ +E NSK L ++ R V++L +LE + K+ ++ +
Sbjct: 1399 QRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLA 1458
Query: 433 EMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKA 492
E KQ+L+ES+ E L + + L+ ++R A +
Sbjct: 1459 EW--------------------KQKLDESQAE----LEAAQKESRSLSTELFKMRNAYEE 1494
Query: 493 IVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTA 552
+V + E + L +++ D E A+ + + + K + + +DL++ L++ + +
Sbjct: 1495 VVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGS 1554
Query: 553 LENE 556
LE+E
Sbjct: 1555 LEHE 1558
Score = 53.1 bits (126), Expect = 1e-06
Identities = 93/457 (20%), Positives = 195/457 (42%), Gaps = 105/457 (22%)
Query: 154 KESCNMETQTSSTFNRDSLAEKLQ-LIDDQFADAYPQRIKFESLEIKLNEYKREIEE--- 209
+E ++ Q + T AEK + L++ + +D ++ E +E L + +I
Sbjct: 1511 EEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDL---QVALEEVEGSLEHEESKILRVQL 1567
Query: 210 ---QLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKS 266
Q+++E+ +K+ KD EI ++K +++ E Q+ + +++++AL L++K
Sbjct: 1568 ELSQVKSELDRKV-IEKDEEIEQLKRNSQRAAEA----LQSVLDAEIRSRNDALRLKKKM 1622
Query: 267 T-------LERIHKHQEI-ETKEIYAQRQLLLKDM-----DLLRGREAELKQRVEAFELN 313
++ H ++++ ET++ Q LKD D LR E +LK+++ E
Sbjct: 1623 EGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNE-DLKEQLAIVERR 1681
Query: 314 QKLQEEKHKSITEALRRQEQNIK-SFEETYD-------------------RKLKNELLKY 353
L E+ + + AL + E+ + S +E D +KL+ ++ +
Sbjct: 1682 NGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQC 1741
Query: 354 QLELKDDY-------------IIRTNRLIEDERKNKEKAVHLQE---------------- 384
Q E+++ I + E+ +K ++ + HL+
Sbjct: 1742 QAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL 1801
Query: 385 ---ELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLK 441
E +A+ K+++ + NRV+ELE EL+ + + K H KVKEM+
Sbjct: 1802 DEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMT------ 1855
Query: 442 EEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFE 501
Q EE LRL + + + ++ ++ R+AE+A + +
Sbjct: 1856 --------------YQAEEDHKNILRLQDLVDKLQAKVKSYK---RQAEEAEEQANTQLS 1898
Query: 502 SCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQ 538
CR+ H +L++ E + ++Q+ +A + + +Q
Sbjct: 1899 RCRRVQH-ELEEAAERADIAESQVNKLRAKSRDVGSQ 1934
Score = 31.2 bits (69), Expect = 5.2
Identities = 35/142 (24%), Positives = 60/142 (42%), Gaps = 29/142 (20%)
Query: 885 QQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESL----------------KI 928
+ +KE+ ERR L E LE + LE+ + R++ E+ L I
Sbjct: 1669 EDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLI 1728
Query: 929 KIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKII----------QQEQDQESADKSS 978
KK+LE ++ E+++ S N EK K I ++EQD + +
Sbjct: 1729 NTKKKLEA--DIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1786
Query: 979 KKMVQEGSLVDTLQSSDKVESL 1000
KK +++ ++ D D+ E L
Sbjct: 1787 KKNLEQ-TVKDLQHRLDEAEQL 1807
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 75.5 bits (184), Expect = 2e-13
Identities = 90/436 (20%), Positives = 188/436 (43%), Gaps = 44/436 (10%)
Query: 102 KEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMET 161
KEK +Q+ LQL++ + E K L + H KE ++
Sbjct: 220 KEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA 279
Query: 162 QTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKF 221
+ + + L +L Q + Q K + E K+ E + +I EQ Q+ K
Sbjct: 280 KLQAQVEENELWNRLN--QQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKM 337
Query: 222 FKDTEIA-----KIKMEAKKKYEKELTM----------------FQNDFEKACQAKSEAL 260
+ E+ K++ + + +EKE M + + + + +
Sbjct: 338 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEE 397
Query: 261 VLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEK 320
+E+ + K QE E K ++ Q + + + + +R +E ++ ++ E +K++EE+
Sbjct: 398 KRQEEEKIREQEKRQEQEAK-MWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEE 456
Query: 321 HKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAV 380
+ E + RQE+ I+ EE + +K E + Q +++ E++ +E+ +
Sbjct: 457 KRQEQEEMWRQEEKIREQEEIWRQK---EKMHEQEKIRKQ---------EEKVWRQEEKM 504
Query: 381 HLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLL 440
H QEE I ++E++ + +++E E E ++ Q I +Q M+ E+ ++M +
Sbjct: 505 HDQEE--KIREQEEKMWRQEEKIREQE---EKIREQEEKIREQEEMMQEQEEKMGEQEEK 559
Query: 441 KEEKLELLAQNKLLKQQLEESR--NENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHE 498
+E+ ++ Q + +++Q E+ R E +R E Q+E+ + ++ + E E
Sbjct: 560 MQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQE 619
Query: 499 EFESCRQALHKQLQDE 514
E + C Q Q Q+E
Sbjct: 620 E-KMCEQEEKMQEQEE 634
Score = 52.0 bits (123), Expect = 3e-06
Identities = 41/160 (25%), Positives = 79/160 (49%), Gaps = 19/160 (11%)
Query: 870 QKQIEEQKEEEKIREQ------------QVKERRQREE--RRQSNLQEVLERERRELEKL 915
Q+Q E ++EEKIREQ Q K R+Q E+ R++ + + E+ R + EK+
Sbjct: 459 QEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKM 518
Query: 916 YQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQ---DQE 972
+++ + I E + KI+++ E E E QE ++K E +++ K+ +QE+ +QE
Sbjct: 519 WRQEEKIREQ-EEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQE 577
Query: 973 SADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEELDDSW 1012
+ K+ ++E + +K+ E+ + W
Sbjct: 578 EKIREQKEKIREQE-EKIWEQEEKIREQEEMMQEQEEKMW 616
Score = 50.4 bits (119), Expect = 8e-06
Identities = 39/126 (30%), Positives = 70/126 (55%), Gaps = 6/126 (4%)
Query: 864 QHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQ-SNLQEVLERERRELEKL-YQERKM 921
Q + +++ Q++EEK+ EQ+ K + Q + RRQ ++E E+ R + EK+ QE K+
Sbjct: 535 QEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKI 594
Query: 922 IEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQ---DQESADKSS 978
E+ KI+ ++E+ E E +M QE K E E+ K+ +QE+ +QE +
Sbjct: 595 WEQEEKIREQEEMMQEQEEKMWEQEEK-MCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQ 653
Query: 979 KKMVQE 984
++ +QE
Sbjct: 654 EEKMQE 659
Score = 49.7 bits (117), Expect = 1e-05
Identities = 37/143 (25%), Positives = 78/143 (54%), Gaps = 13/143 (9%)
Query: 864 QHPSVDQKQIEEQKEEEKIREQQ-VKERRQREERRQSNLQEVLERERRELEKLYQERKMI 922
Q + +++ + ++EEKI EQ+ ++E +R+E+ + Q E + RE E+++++++ +
Sbjct: 428 QEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQ---EEKIREQEEIWRQKEKM 484
Query: 923 EESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQ---DQESADKSSK 979
E KI+ ++E E +M +QE K + E + KI +QE+ +QE + +
Sbjct: 485 HEQEKIRKQEEKVWRQEEKMHDQEEKIRE-QEEKMWRQEEKIREQEEKIREQEEKIREQE 543
Query: 980 KMVQE-----GSLVDTLQSSDKV 997
+M+QE G + +Q +K+
Sbjct: 544 EMMQEQEEKMGEQEEKMQEQEKM 566
Score = 47.8 bits (112), Expect = 5e-05
Identities = 34/127 (26%), Positives = 64/127 (50%), Gaps = 15/127 (11%)
Query: 870 QKQIEEQKE-----EEKIREQQVKERRQRE--------ERRQSNLQEVLERERRELEKLY 916
+++I+EQ+E EEKIREQ+ K RRQ E RRQ + E + R LE++
Sbjct: 313 EEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMM 372
Query: 917 --QERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESA 974
+E K+ E K+ ++++ + E ++I+++ E + + + + + +E
Sbjct: 373 WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 432
Query: 975 DKSSKKM 981
+ KKM
Sbjct: 433 REQEKKM 439
Score = 47.8 bits (112), Expect = 5e-05
Identities = 33/128 (25%), Positives = 70/128 (54%), Gaps = 15/128 (11%)
Query: 870 QKQIEEQKE-----EEKIREQQ--VKERRQREERRQSNLQEVLERERRELEKLYQERKMI 922
+++I EQ+E EEKIREQ+ ++E+ ++ ++ +QE E+ + EK+ ++ KM
Sbjct: 508 EEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMR 567
Query: 923 EESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQ------EQDQESADK 976
+ KI+ ++E E + ++ QE +K E + + +++Q+ EQ+++ ++
Sbjct: 568 RQEEKIREQEEKIREQKEKIREQE--EKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 625
Query: 977 SSKKMVQE 984
K QE
Sbjct: 626 EEKMQEQE 633
Score = 47.0 bits (110), Expect = 9e-05
Identities = 32/124 (25%), Positives = 71/124 (57%), Gaps = 5/124 (4%)
Query: 864 QHPSVDQKQIEEQKEEEKIREQQ--VKERRQREERRQSNLQEVLERERRELEKL-YQERK 920
Q + +++ + +++EEKIREQ+ ++E+ ++ ++ +QE E+ RR+ EK+ QE K
Sbjct: 521 QEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQ-EKMRRQEEKIREQEEK 579
Query: 921 MIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKK 980
+ E+ KI+ ++E E E ++ QE + E E+ K+ +QE+ + ++ ++
Sbjct: 580 IREQKEKIREQEEKIWEQEEKIREQE-EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR 638
Query: 981 MVQE 984
++
Sbjct: 639 QEEK 642
Score = 46.2 bits (108), Expect = 2e-04
Identities = 33/132 (25%), Positives = 70/132 (53%), Gaps = 21/132 (15%)
Query: 874 EEQKEEEKIREQQVK----------ERRQREE----RRQSNLQEVLERERRELEKLYQER 919
E+ E+EKIREQ+ K E+RQ +E R++ ++E E+ R + +K++++
Sbjct: 384 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQE 443
Query: 920 KMIEESLKIKIKKELEMENELEMSNQEIKDKSA--HSENPLEKYMKIIQQE-----QDQE 972
+ I E KI+ +++ + + E+ ++I+++ + + + KI +QE Q+++
Sbjct: 444 EKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEK 503
Query: 973 SADKSSKKMVQE 984
D+ K QE
Sbjct: 504 MHDQEEKIREQE 515
Score = 45.8 bits (107), Expect = 2e-04
Identities = 46/187 (24%), Positives = 83/187 (44%), Gaps = 15/187 (8%)
Query: 792 EQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSH 851
+Q+ ++R++ ++Q+ E + + K E+ E E M RQ EM M
Sbjct: 297 QQEEKMWRQEEKIQEWEE--KIQEQEEKIREQEEKIREQEEKMRRQEEM--------MWE 346
Query: 852 VDAAAAAVPLSYQHPSVDQKQIEEQ--KEEEKIREQQVKERRQREERRQSNLQEVLERER 909
+ +++EE ++EEKIRE + K Q + R Q ++ E+ R
Sbjct: 347 KEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIR 406
Query: 910 RELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQ 969
+ ++ QE KM + KI+ ++E E E +M QE K H + + + K +QE+
Sbjct: 407 EQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEK---IHEQEKIREEEKRQEQEE 463
Query: 970 DQESADK 976
+K
Sbjct: 464 MWRQEEK 470
Score = 44.7 bits (104), Expect = 5e-04
Identities = 42/135 (31%), Positives = 69/135 (51%), Gaps = 15/135 (11%)
Query: 864 QHPSVDQKQIEEQKEEEKIREQQVKERRQ----REERRQSNLQEVLERERRELEKLYQER 919
Q V +++ + +EEKIREQ+ K RQ RE+ + QE RE+ E+ + QE
Sbjct: 493 QEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQ-EQEE 551
Query: 920 KMIEESLKI----KIKKELEMENELEMSNQEIKDKSAHSENPL-EKYMKI-----IQQEQ 969
KM E+ K+ K++++ E E E +E K+K E + E+ KI + QEQ
Sbjct: 552 KMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQ 611
Query: 970 DQESADKSSKKMVQE 984
+++ ++ K QE
Sbjct: 612 EEKMWEQEEKMCEQE 626
Score = 42.7 bits (99), Expect = 0.002
Identities = 50/203 (24%), Positives = 98/203 (48%), Gaps = 15/203 (7%)
Query: 797 LYRRQTELQDKSEFSDVDKLAFKDN-EEFESSFESAGNM--PRQLEMGGLSPAGDMSHVD 853
L + +LQ+K + + +K + N +E + E A + +QL+ ++ V
Sbjct: 219 LKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVS 278
Query: 854 AAAAA-VPLSYQHPSVDQKQIEEQ-KEEEKIREQQVK----ERRQREERRQSNLQEVLER 907
A A V + ++Q+Q E+ ++EEKI+E + K E + RE+ + QE E+
Sbjct: 279 AKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQE--EK 336
Query: 908 ERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQ 967
RR+ E ++++ + + ++ +KE +M LE E ++K E + + KI +Q
Sbjct: 337 MRRQEEMMWEKEEKMRRQEEMMWEKEEKM-RRLEEMMWEKEEKIRELEEKMHEQEKIREQ 395
Query: 968 E---QDQESADKSSKKMVQEGSL 987
E Q++E + K+ QE +
Sbjct: 396 EEKRQEEEKIREQEKRQEQEAKM 418
Score = 37.4 bits (85), Expect = 0.072
Identities = 38/174 (21%), Positives = 82/174 (47%), Gaps = 16/174 (9%)
Query: 170 DSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAK 229
+ + ++ + I +Q + Q K E K+ E + +I EQ Q+ K + E
Sbjct: 502 EKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEE--- 558
Query: 230 IKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLL 289
KM+ ++K ++ + EK + K + +RE+ E+I + +E +I Q +++
Sbjct: 559 -KMQEQEKMRRQEEKIREQEEKIREQKEK---IREQE--EKIWEQEE----KIREQEEMM 608
Query: 290 LKDMDLLRGRE---AELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEE 340
+ + + +E E +++++ E + QEEK LR+QE+ ++ +E
Sbjct: 609 QEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 662
Score = 34.3 bits (77), Expect = 0.61
Identities = 17/71 (23%), Positives = 46/71 (64%), Gaps = 1/71 (1%)
Query: 870 QKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKL-YQERKMIEESLKI 928
+++I EQ+E+ + +E+ ++E+ ++ ++ + E E+ + + EK+ QE KM E+ +++
Sbjct: 591 EEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL 650
Query: 929 KIKKELEMENE 939
+ ++E E++
Sbjct: 651 RQQEEKMQEHQ 661
Score = 30.4 bits (67), Expect = 8.8
Identities = 22/88 (25%), Positives = 38/88 (43%)
Query: 894 EERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAH 953
++++ E L +ER L + +E LK K K E +E EI+
Sbjct: 187 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKE 246
Query: 954 SENPLEKYMKIIQQEQDQESADKSSKKM 981
+ LE+ ++ Q+Q Q AD K++
Sbjct: 247 LKRKLERAKLLLPQQQLQAEADHLGKEL 274
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 75.5 bits (184), Expect = 2e-13
Identities = 153/842 (18%), Positives = 343/842 (40%), Gaps = 104/842 (12%)
Query: 152 QAKESCNMETQTSSTF---NRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIE 208
QA+++ M+ QT D L + +++ + + + + F S E+K E
Sbjct: 145 QARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKK-------E 197
Query: 209 EQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTL 268
LR + K+ +K+ + ++ ++ ++T+ E Q L ++ S+
Sbjct: 198 RALRKDEASKITIWKE----QYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSR 253
Query: 269 ER---IHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSIT 325
+ + E + ++A+ + K++ LLR E++ R+E + ++E K +
Sbjct: 254 TGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLL 313
Query: 326 EALRRQEQNIKSFEETYDRKLK---NELLKYQLELKDDYIIRTNRLIEDER----KNKEK 378
E L+ + + K+ EE ++R + E+ + LE + + N ++ +E +N
Sbjct: 314 EMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPD 373
Query: 379 AVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYS 438
+ + I K +++ +++LE E++ +K+ T++ ++++ +S
Sbjct: 374 SAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHS 433
Query: 439 LLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHE 498
+ K+E L K++L + L + A E+ ++EL + + ++
Sbjct: 434 KFMKNKVEQL------KEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQT 487
Query: 499 EFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVY 558
+ E+ L Q D +H LK + + L T+V L+L+L++ +T L +
Sbjct: 488 KLET----LTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKT- 542
Query: 559 CNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEG 618
KQ G G + D L+ ++ NVL + + + ++
Sbjct: 543 ---KQIQDMAEEKGTQAGEIHDLK-----DMLDVKERKVNVLQKKIEN---------LQE 585
Query: 619 SSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHLLEA 678
D + + +++ K RVK LQ + + A + + LA K L E
Sbjct: 586 QLRDKEKQ-MSSLKERVKSLQADTTNTDTAL---------TTLEEALAEKERTIERLKEQ 635
Query: 679 FKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEA-LTGSAASRLRGGTSSRRLSST 737
ER ++ + + + + L+E+ +++ L+ AS L + L+S+
Sbjct: 636 -----RDRDERE--KQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASS 688
Query: 738 PLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGL 797
L K R E+ LE C + + S + H ++ +SP
Sbjct: 689 GLKKDSRLKTLEIALE-------QKKEEC---LKMESQLKKAHEAALEARASP------- 731
Query: 798 YRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAA 857
E+ D+ + + + +KD S ++ + R LE+ + + D A
Sbjct: 732 -----EMSDRIQHLEREITRYKDE-----SSKAQAEVDRLLEILK-EVENEKNDKDKKIA 780
Query: 858 AVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQ 917
+ + + K++ K +E++ +++ + + RR+ NL + ++ + L K
Sbjct: 781 ELERQVKDQN---KKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDD 837
Query: 918 ERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSE-NPLEKYMKIIQQEQDQESADK 976
+ +EE+L+ + ++ E E+ ++ +E +A + L M+ ++QE + A
Sbjct: 838 RIEELEEALRESV--QITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKL 895
Query: 977 SS 978
SS
Sbjct: 896 SS 897
Score = 55.5 bits (132), Expect = 3e-07
Identities = 103/468 (22%), Positives = 206/468 (44%), Gaps = 77/468 (16%)
Query: 97 ESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKES 156
E G ++ ++D+L +K + L K + + ++ K M LKE + QA +
Sbjct: 551 EKGTQAGEIHDLKDMLD-VKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTT 609
Query: 157 CNMETQTSSTFNRDSLAEKLQLID----DQFADAYPQRIKFESLEIKLNEYKREIEEQLR 212
T T+ T ++LAEK + I+ + D ++ + ++ + L + K ++ L+
Sbjct: 610 ---NTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVS-LLQ 665
Query: 213 AEMCQK------LK----------FFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAK 256
++ +K LK KD+ + +++ ++K E+ L M ++ +KA +A
Sbjct: 666 GDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKM-ESQLKKAHEAA 724
Query: 257 SEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKL 316
EA E S +RI +H E E + + D +AE+ + +E + +
Sbjct: 725 LEARASPEMS--DRI-QHLERE----------ITRYKDESSKAQAEVDRLLEILKEVENE 771
Query: 317 QEEKHKSITEALRR-QEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKN 375
+ +K K I E R+ ++QN +K+ N K Q+E K ++ +++E+ R+
Sbjct: 772 KNDKDKKIAELERQVKDQN---------KKVANLKHKEQVEKK-----KSAQMLEEARRR 817
Query: 376 KEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMS 435
++ +N ++L S+ + + ELE +S+ IT + M+ +E S
Sbjct: 818 EDN----------LNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMV--LAQEES 865
Query: 436 DYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVV 495
+ +++ ELL + +KQ+LE + + LA+ L + E RK +
Sbjct: 866 ARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLE---- 921
Query: 496 EHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLK 543
E E ++AL + ++ + A +L +S K +VA LK
Sbjct: 922 --EVLEMKQEALLAAISEKDANIA-----LLELSSSKKKTQEEVAALK 962
Score = 43.9 bits (102), Expect = 8e-04
Identities = 145/759 (19%), Positives = 291/759 (38%), Gaps = 105/759 (13%)
Query: 276 EIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAF---ELNQKLQEEKHKSITEALRRQE 332
+ + KE+ + LL KD+++ + + ++ F EL ++ K ++ + +++
Sbjct: 155 QTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQ 214
Query: 333 QNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDE---RKNKEKAVHLQEELIAI 389
+ EE ++ + L+ +L ++ D N+L + + R + L EE
Sbjct: 215 YRVVQ-EENQHMQMTIQALQDELRIQRDL----NQLFQQDSSSRTGEPCVAELTEENFQR 269
Query: 390 NSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLA 449
+ E + KEL L ++++ L I Q LN + + + +KL +
Sbjct: 270 LHAEHE-----RQAKELFLLRKTLEEMELRIETQKQTLNARDESI--------KKLLEML 316
Query: 450 QNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHK 509
Q+K L + E +E R RLA+ + + L + EK E R+ +H+
Sbjct: 317 QSKGLSAKATEEDHERTR---RLAEAEMHVHHLESLLEQKEK-------ENSMLREEMHR 366
Query: 510 QLQDEIEHSAQLKA--QILGYKAS-VKSLTTQVADLK--LQLKQTQTALENEVYCNP-KQ 563
+ ++ + SA+ KA ++ K S + S+ + DL+ +Q+ ++ AL E KQ
Sbjct: 367 RFENAPD-SAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQ 425
Query: 564 SVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDS 623
+ RS + + V E+S + Q L + A E S D+
Sbjct: 426 MEVYRSHSKFMKNKVEQLKEELS-----SKEAQWEELKKKAAGLQAEIGQVKQELSRKDT 480
Query: 624 DLEFVANTKARVKELQQEAERLEKAFRS--YHRRVIKNS--AKSPLAA---KSPPSLHLL 676
+L LQ + E L F H V+K S AK AA +L L
Sbjct: 481 EL----------LALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLR 530
Query: 677 EAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSS 736
K + + I +D + Q G + + D+++ +
Sbjct: 531 LEEKETMLNKKTKQI--QDMAEEKGTQAGEIHDLKDMLDV---------------KERKV 573
Query: 737 TPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVG 796
L K +L+ ++ R S +R+ + ++ + +K
Sbjct: 574 NVLQKKIENLQEQL------RDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKER 627
Query: 797 LYRRQTELQDKSEFSDVDKLAFKDN--EEFESSFESAGNMPRQLEMGGLSPAGDMSHVDA 854
R E +D+ E +++ DN ++ + E + L S H +
Sbjct: 628 TIERLKEQRDRDEREKQEEI---DNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASS 684
Query: 855 AAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQR--EERRQSNLQEVLERERREL 912
A++ + +E++KEE E Q+K+ + E R + + ++ RE+
Sbjct: 685 LASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREI 744
Query: 913 EKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQE 972
+ E + ++ + LE+ E+E + K A LE+ +K +Q+++
Sbjct: 745 TRYKDE----SSKAQAEVDRLLEILKEVENEKNDKDKKIAE----LERQVK----DQNKK 792
Query: 973 SADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEELDDS 1011
A+ K+ V++ L+ + + E S ++L DS
Sbjct: 793 VANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDS 831
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 74.7 bits (182), Expect = 4e-13
Identities = 169/902 (18%), Positives = 352/902 (39%), Gaps = 100/902 (11%)
Query: 144 LKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEY 203
LKEL + H + T ++ L E+LQ + +A+A E + ++L
Sbjct: 875 LKELEQKH-----------SQLTEEKNLLQEQLQAETELYAEA-------EEMRVRLAAK 916
Query: 204 KREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLR 263
K+E+EE L EM +L+ +D +++ E KK ++ L D E+ + + A R
Sbjct: 917 KQELEEILH-EMEARLEEEEDRG-QQLQAERKKMAQQML-----DLEEQLEEEEAA---R 966
Query: 264 EKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAE-LKQRVEAFELNQKLQEEKHK 322
+K LE++ +I+ E L++ D + +E + L++R+ N +EEK K
Sbjct: 967 QKLQLEKVTAEAKIKKLE---DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1023
Query: 323 SITEALRRQEQNIKSFEETY--DRKLKNELLKYQLELKDD-------YIIRTNRLIEDER 373
++T+ + E I E + K + EL K + +L+ D ++ E +
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 374 KNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKE 433
+ +K LQ L ++ + + N ++ +++ELE + ++ + E
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ-------------EDLDSE 1130
Query: 434 MSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAI 493
+ + +++K +L + + LK +LE++ + A+ E+ V +K L + ++
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190
Query: 494 VVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVA-------DLKLQL 546
+ +E ++L +++E + KA + K +++ +A K ++
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250
Query: 547 KQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISG--DFLNNPFKQENVLARMV 604
+ + LE +V + +N V E+ LN + LA+ V
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 605 ASRITNYPTAWVEGSSPDSDLEFVANTKARVK-ELQQEAERLEKAFRSYHRRVIKNSAKS 663
AS SS D + + + R K + + +LE+ R +++
Sbjct: 1311 ASL-----------SSQLQDTQELLQEETRQKLNVSTKLRQLEE-----ERNSLQDQLDE 1354
Query: 664 PLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAAS 723
+ AK H+ ++ S + F E+ + +E ++ + AA+
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414
Query: 724 RLRGGTSSRRLSSTPLPKAKRSLESEMYL-EGLGRSHIASPSPCPDRMPLPSPTESRHSL 782
+ + RL L L+++ L L + + + S
Sbjct: 1415 YDKLEKTKNRLQQ-ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 783 SIPPVSSPPEQKVGLYRRQTE-LQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMG 841
+ + + L R E L+ K E +K+ + E+ SS + G +LE
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533
Query: 842 GLSPAGDMSHVDAAAAAVPLSYQ-------HPSVDQKQIEEQKEEE-KIREQQVKERRQR 893
+ M + + Q V+ + ++ Q E + + R++Q +E+R++
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1593
Query: 894 EERRQSNLQEVLERERRELEKLYQERKMIEESLK-------IKIKKELEMENELEMSNQE 946
+R+ + LE ER++ +K +E LK IK E +L +
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1653
Query: 947 IKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHE 1006
+KD E+ +I ++ E KS + + + L + L ++++ E
Sbjct: 1654 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ--LQEDLAAAERARKQADLEKE 1711
Query: 1007 EL 1008
EL
Sbjct: 1712 EL 1713
Score = 73.2 bits (178), Expect = 1e-12
Identities = 177/849 (20%), Positives = 340/849 (40%), Gaps = 98/849 (11%)
Query: 193 FESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKA 252
F ++ L ++E E Q + + QK K + + A+ +++ ++ +LT +N ++
Sbjct: 838 FTKVKPLLQVTRQEEEMQAKEDELQKTK--ERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 253 CQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRV-EAFE 311
QA++E E+ + K QE+E + ++ L ++ D + +AE K+ + +
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELE-EILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954
Query: 312 LNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIED 371
L ++L+EE EA R++ Q K E +KL++E+L + DD + N+L ++
Sbjct: 955 LEEQLEEE------EAARQKLQLEKVTAEAKIKKLEDEIL-----VMDD---QNNKLSKE 1000
Query: 372 ERKNKEKAVHLQEELIAINSKKEELNQSVNR----VKELELELESVKAQSLAITKQNHML 427
+ +E+ L L K + L + N+ + ELE+ L+ + + K L
Sbjct: 1001 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1060
Query: 428 NEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELR 487
D S E+ +L AQ LK QL + E L RL + K++R
Sbjct: 1061 E------GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1114
Query: 488 KAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLK 547
+ E I E+ +S R A +K + + + +L+A + ++ S TQ +L+ + +
Sbjct: 1115 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ-QELRAKRE 1173
Query: 548 QTQT----ALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARM 603
Q T AL+ E + Q R + + +Q R
Sbjct: 1174 QEVTVLKKALDEETRSHEAQVQEMRQKH---------------AQAVEELTEQLEQFKRA 1218
Query: 604 VASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKS 663
A+ N T E + +L + K V+ +++ E + +S K S
Sbjct: 1219 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS------KCSDGE 1272
Query: 664 PLAAKSPPSLHLLE-AFKNITSSSPERHIFGEDRVVSEQPQVGTLEER-NDVVEALTGSA 721
A+ +H L+ +++T E E + + V +L + D E L
Sbjct: 1273 RARAELNDKVHKLQNEVESVTGMLNE----AEGKAIKLAKDVASLSSQLQDTQELLQEET 1328
Query: 722 ASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIA--------SPSPCPDRMPLP 773
+L T R+L + L+ EM + HI+ S D
Sbjct: 1329 RQKLNVSTKLRQLEE-ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1387
Query: 774 SPTE---SRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNE-EFESSFE 829
E R I ++ E+K Y + + +++ + D + DN+ + S+ E
Sbjct: 1388 EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE 1447
Query: 830 SAGNMPRQL--EMGGLSP--AGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEE----EK 881
QL E +S A + +A A + ++ E KEE K
Sbjct: 1448 KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1507
Query: 882 IREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLK--------IKIKKE 933
+ + ++++ ++ N+ E LE+ +R LE +E K E L+ K++ E
Sbjct: 1508 MLKAEMEDLVSSKDDVGKNVHE-LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566
Query: 934 LEM-------ENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGS 986
+ M E +L+ +++ ++K + L +Y ++ E+ Q + ++KK + EG
Sbjct: 1567 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL-EGD 1625
Query: 987 LVDTLQSSD 995
L D +D
Sbjct: 1626 LKDLELQAD 1634
Score = 71.2 bits (173), Expect = 4e-12
Identities = 180/892 (20%), Positives = 341/892 (38%), Gaps = 165/892 (18%)
Query: 170 DSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAK 229
+ L L +DD+ A K LE +++ ++E L +E + K K
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISD----LQEDLDSERAARNKAEKQKRDLG 1145
Query: 230 IKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLE---RIHKHQEIETKEIYAQR 286
++EA K E E T+ ++ +AK E V K L+ R H+ Q E ++ +AQ
Sbjct: 1146 EELEALKT-ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204
Query: 287 -QLLLKDMDLLRGREAELKQRVEAFE------------LNQKLQEEKHKSITEALRRQEQ 333
+ L + ++ + +A L + + E L Q QE +HK + L Q Q
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK--KKLEAQVQ 1262
Query: 334 NIKSFEETYDR---KLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAIN 390
++S +R +L +++ K Q E++ T L E E K A+ L +++ +++
Sbjct: 1263 ELQSKCSDGERARAELNDKVHKLQNEVESV----TGMLNEAEGK----AIKLAKDVASLS 1314
Query: 391 SK--------KEELNQSVN---RVKELELELESVKAQ-----------SLAITKQNHMLN 428
S+ +EE Q +N ++++LE E S++ Q I+ N L+
Sbjct: 1315 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1374
Query: 429 EKVKEMSDYS----LLKEEKLELLAQNKLLKQQLEESRNENLRL---LNRLAQPAPELAV 481
+ K++ D++ L+E K + + L QQ EE +L NRL Q +L V
Sbjct: 1375 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1434
Query: 482 -----------FQKELRKAEKAIVVEH--------------------------------- 497
+K+ RK ++ + E
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 498 -----EEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTA 552
EE E + L +++D + + + + S ++L TQ+ ++K QL++
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE---- 1550
Query: 553 LENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYP 612
LE+E+ Q+ D + + N+ G+ D L +Q R + ++ Y
Sbjct: 1551 LEDEL-----QATEDAKLR--LEVNMQALKGQFERD-LQARDEQNEEKRRQLQRQLHEYE 1602
Query: 613 TAW----------------VEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRV 656
T +EG D +L+ + K R + ++Q +L+ + + R +
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMKDFQREL 1661
Query: 657 IKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEA 716
+ A++ E K S + ED +E+ + E+ ++ E
Sbjct: 1662 -----EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716
Query: 717 LTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPT 776
L S + R RRL + + + + LE E + DR+ +
Sbjct: 1717 LASSLSGRNALQDEKRRLEAR-IAQLEEELEEEQ----------GNMEAMSDRVRKATQQ 1765
Query: 777 ESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPR 836
+ S + S QK R+Q E Q+K S + ++ +F+S+ +
Sbjct: 1766 AEQLSNELATERSTA-QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1824
Query: 837 QLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREER 896
QLE A + A S + K+I Q E+E+ +Q KE+ ++
Sbjct: 1825 QLEEQVEQEAREKQ-------AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1877
Query: 897 RQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIK 948
R L+ LE E +++ R+ ++ L + M E+ +++
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 70.5 bits (171), Expect = 8e-12
Identities = 142/732 (19%), Positives = 289/732 (39%), Gaps = 92/732 (12%)
Query: 296 LRGREAEL---KQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLK 352
++ +E EL K+R + E K E+KH +TE ++ +++ E Y + E ++
Sbjct: 854 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY---AEAEEMR 910
Query: 353 YQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELES 412
+L K E E E L+EE + E + ++ +LE +LE
Sbjct: 911 VRLAAKKQ---------ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961
Query: 413 VKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLA-QNKLLKQQL---------EESR 462
+A + + K+K++ D L+ +++ L+ + KLL++++ EE +
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 463 NENL-RLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQL 521
+NL +L N+ EL V L+K EK+ +E E ++ L D E A L
Sbjct: 1022 AKNLTKLKNKHESMISELEV---RLKKEEKS----RQELEKLKRKLEGDASDFHEQIADL 1074
Query: 522 KAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPC 581
+AQI L Q+A + +L+ L++E+ R + G I+
Sbjct: 1075 QAQI-------AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 582 NGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQE 641
+ E + N KQ+ L + + T + L+ A + + +QE
Sbjct: 1128 DSERAA--RNKAEKQKRDLGEELEALKTEL----------EDTLDSTATQQELRAKREQE 1175
Query: 642 AERLEKAF----RSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNI---------TSSSPE 688
L+KA RS+ +V + K A + LE FK T
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEE--LTEQLEQFKRAKANLDKNKQTLEKEN 1233
Query: 689 RHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLES 748
+ GE RV+ + Q +E + +EA S+ G +R + + K + +ES
Sbjct: 1234 ADLAGELRVLGQAKQ--EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVES 1291
Query: 749 EMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKS 808
+ L + + D L S + L + QK+ + + +L+++
Sbjct: 1292 VTGM--LNEAEGKAIKLAKDVASLSSQLQDTQEL----LQEETRQKLNVSTKLRQLEEER 1345
Query: 809 EFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSV 868
++ + E+ N+ R + + + + A+ V +
Sbjct: 1346 N---------SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1396
Query: 869 DQKQIE---EQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEES 925
QK+IE +Q EE+ ++++ + R ++ +L L+ +R+ + L ++++ ++
Sbjct: 1397 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1456
Query: 926 LKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEG 985
L + + +E + + E ++K + + + ++ +++ E +K K
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK-----A 1511
Query: 986 SLVDTLQSSDKV 997
+ D + S D V
Sbjct: 1512 EMEDLVSSKDDV 1523
Score = 67.0 bits (162), Expect = 8e-11
Identities = 205/1069 (19%), Positives = 403/1069 (37%), Gaps = 120/1069 (11%)
Query: 14 LSQDELRKK--LYQTFKDRGILDTLKTQLRNQLIHELMHPVLSGELQPRSISVEGSSL-- 69
L Q++L+ + LY ++ + K Q +++HE+ + E + + + E +
Sbjct: 891 LLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQ 950
Query: 70 -LIGASNSLVADHLQRCGYEYSLSVFFPESGLAK--EKVFTMQDLLQLIKINPTSSLYKS 126
++ L + R + L E+ + K +++ M D Q K++ L +
Sbjct: 951 QMLDLEEQLEEEEAAR--QKLQLEKVTAEAKIKKLEDEILVMDD--QNNKLSKERKLLEE 1006
Query: 127 LVSGSD----KENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQ 182
+S +E +K + LK E ++ ++ + S + L KL+
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE----- 1061
Query: 183 FADAYPQRIKFESLEIKLNEYKREI---EEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYE 239
DA + L+ ++ E K ++ EE+L+A + + D EIA+ KK E
Sbjct: 1062 -GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL-----DDEIAQKNNALKKIRE 1115
Query: 240 KE--LTMFQNDF--EKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDL 295
E ++ Q D E+A + K+E LE + E Q++L K
Sbjct: 1116 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1175
Query: 296 LRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQL 355
+ + L + + E + +KH E L Q + K + D+ K L K
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN-KQTLEKENA 1234
Query: 356 ELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKA 415
+L + + E E K K+ +QE + + + ++V +L+ E+ESV
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294
Query: 416 QSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQP 475
MLNE + L ++ L +Q + ++ L+E + L + +L Q
Sbjct: 1295 ----------MLNEAEGKAIK---LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1341
Query: 476 APELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSL 535
E Q +L + +A + E L+ QL D + + + + K
Sbjct: 1342 EEERNSLQDQLDEEMEA----KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 536 TTQVADLKLQLKQTQTALEN-EVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPF 594
++ +L Q ++ A + E N Q +D V L N + N E +
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Query: 595 KQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHR 654
+E ++ A A E ++ +A E ++E ER K ++
Sbjct: 1458 AEEKNISSKYADERDR---AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME 1514
Query: 655 RVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDV- 713
++ S+K + ++H LE K + E + + E + R +V
Sbjct: 1515 DLV--SSKDDVGK----NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1568
Query: 714 VEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPC--PDRMP 771
++AL G L+ L + E+E+ E R+ A+ D
Sbjct: 1569 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628
Query: 772 LPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESA 831
L +S + + + + Q EL+D D K+NE+ S E A
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE-A 1687
Query: 832 GNMPRQLEMGGLSPAGDMSHVD----AAAAAVPLSYQHPSVDQK--------QIEEQKEE 879
M Q ++ A + ++ A A LS ++ D+K Q+EE+ EE
Sbjct: 1688 DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1747
Query: 880 EKIREQQVKER-----RQREE------------RRQSNLQEVLERERRELEKLYQERK-- 920
E+ + + +R +Q E+ ++ + ++ LER+ +EL E +
Sbjct: 1748 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1807
Query: 921 -----------------MIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMK 963
+EE ++ + +++ L+ ++++K+ E+ E+ M
Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED--ERKM- 1864
Query: 964 IIQQEQDQESADKSSKKMVQ-EGSLVDTLQSSDKVESLTGFSHEELDDS 1011
EQ +E A+K + ++ Q + L + + S ++ + ELD++
Sbjct: 1865 ---AEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1910
Score = 46.2 bits (108), Expect = 2e-04
Identities = 48/239 (20%), Positives = 104/239 (43%), Gaps = 18/239 (7%)
Query: 784 IPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNM-PRQLEMGG 842
+ P+ Q+ + ++ ELQ E + K+ E+ S N+ QL+
Sbjct: 841 VKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ--- 897
Query: 843 LSPAGDMSHVDAAAAAVPLSYQHPSVDQ--KQIEEQKEEEKIREQQVKERRQREERRQSN 900
A + +A V L+ + +++ ++E + EEE+ R QQ++ R++ ++ +
Sbjct: 898 ---AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954
Query: 901 LQEVLERERRELEKLYQER-------KMIEESLKIKIKKELEMENELEMSNQEIKDKSAH 953
L+E LE E +KL E+ K +E+ + + + ++ E ++ + I D + +
Sbjct: 955 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 954 SENPLEKYMKIIQQEQDQES--ADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEELDD 1010
EK + + + ES ++ + +E S + + K+E HE++ D
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 74.7 bits (182), Expect = 4e-13
Identities = 169/902 (18%), Positives = 352/902 (39%), Gaps = 100/902 (11%)
Query: 144 LKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEY 203
LKEL + H + T ++ L E+LQ + +A+A E + ++L
Sbjct: 882 LKELEQKH-----------SQLTEEKNLLQEQLQAETELYAEA-------EEMRVRLAAK 923
Query: 204 KREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLR 263
K+E+EE L EM +L+ +D +++ E KK ++ L D E+ + + A R
Sbjct: 924 KQELEEILH-EMEARLEEEEDRG-QQLQAERKKMAQQML-----DLEEQLEEEEAA---R 973
Query: 264 EKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAE-LKQRVEAFELNQKLQEEKHK 322
+K LE++ +I+ E L++ D + +E + L++R+ N +EEK K
Sbjct: 974 QKLQLEKVTAEAKIKKLE---DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1030
Query: 323 SITEALRRQEQNIKSFEETY--DRKLKNELLKYQLELKDD-------YIIRTNRLIEDER 373
++T+ + E I E + K + EL K + +L+ D ++ E +
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 374 KNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKE 433
+ +K LQ L ++ + + N ++ +++ELE + ++ + E
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ-------------EDLDSE 1137
Query: 434 MSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAI 493
+ + +++K +L + + LK +LE++ + A+ E+ V +K L + ++
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197
Query: 494 VVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVA-------DLKLQL 546
+ +E ++L +++E + KA + K +++ +A K ++
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257
Query: 547 KQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISG--DFLNNPFKQENVLARMV 604
+ + LE +V + +N V E+ LN + LA+ V
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 605 ASRITNYPTAWVEGSSPDSDLEFVANTKARVK-ELQQEAERLEKAFRSYHRRVIKNSAKS 663
AS SS D + + + R K + + +LE+ R +++
Sbjct: 1318 ASL-----------SSQLQDTQELLQEETRQKLNVSTKLRQLEE-----ERNSLQDQLDE 1361
Query: 664 PLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAAS 723
+ AK H+ ++ S + F E+ + +E ++ + AA+
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421
Query: 724 RLRGGTSSRRLSSTPLPKAKRSLESEMYL-EGLGRSHIASPSPCPDRMPLPSPTESRHSL 782
+ + RL L L+++ L L + + + S
Sbjct: 1422 YDKLEKTKNRLQQ-ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 783 SIPPVSSPPEQKVGLYRRQTE-LQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMG 841
+ + + L R E L+ K E +K+ + E+ SS + G +LE
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540
Query: 842 GLSPAGDMSHVDAAAAAVPLSYQ-------HPSVDQKQIEEQKEEE-KIREQQVKERRQR 893
+ M + + Q V+ + ++ Q E + + R++Q +E+R++
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1600
Query: 894 EERRQSNLQEVLERERRELEKLYQERKMIEESLK-------IKIKKELEMENELEMSNQE 946
+R+ + LE ER++ +K +E LK IK E +L +
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1660
Query: 947 IKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHE 1006
+KD E+ +I ++ E KS + + + L + L ++++ E
Sbjct: 1661 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ--LQEDLAAAERARKQADLEKE 1718
Query: 1007 EL 1008
EL
Sbjct: 1719 EL 1720
Score = 73.2 bits (178), Expect = 1e-12
Identities = 177/849 (20%), Positives = 340/849 (40%), Gaps = 98/849 (11%)
Query: 193 FESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKA 252
F ++ L ++E E Q + + QK K + + A+ +++ ++ +LT +N ++
Sbjct: 845 FTKVKPLLQVTRQEEEMQAKEDELQKTK--ERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 253 CQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRV-EAFE 311
QA++E E+ + K QE+E + ++ L ++ D + +AE K+ + +
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELE-EILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961
Query: 312 LNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIED 371
L ++L+EE EA R++ Q K E +KL++E+L + DD + N+L ++
Sbjct: 962 LEEQLEEE------EAARQKLQLEKVTAEAKIKKLEDEIL-----VMDD---QNNKLSKE 1007
Query: 372 ERKNKEKAVHLQEELIAINSKKEELNQSVNR----VKELELELESVKAQSLAITKQNHML 427
+ +E+ L L K + L + N+ + ELE+ L+ + + K L
Sbjct: 1008 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1067
Query: 428 NEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELR 487
D S E+ +L AQ LK QL + E L RL + K++R
Sbjct: 1068 E------GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1121
Query: 488 KAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLK 547
+ E I E+ +S R A +K + + + +L+A + ++ S TQ +L+ + +
Sbjct: 1122 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ-QELRAKRE 1180
Query: 548 QTQT----ALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARM 603
Q T AL+ E + Q R + + +Q R
Sbjct: 1181 QEVTVLKKALDEETRSHEAQVQEMRQKH---------------AQAVEELTEQLEQFKRA 1225
Query: 604 VASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKS 663
A+ N T E + +L + K V+ +++ E + +S K S
Sbjct: 1226 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS------KCSDGE 1279
Query: 664 PLAAKSPPSLHLLE-AFKNITSSSPERHIFGEDRVVSEQPQVGTLEER-NDVVEALTGSA 721
A+ +H L+ +++T E E + + V +L + D E L
Sbjct: 1280 RARAELNDKVHKLQNEVESVTGMLNE----AEGKAIKLAKDVASLSSQLQDTQELLQEET 1335
Query: 722 ASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIA--------SPSPCPDRMPLP 773
+L T R+L + L+ EM + HI+ S D
Sbjct: 1336 RQKLNVSTKLRQLEE-ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1394
Query: 774 SPTE---SRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNE-EFESSFE 829
E R I ++ E+K Y + + +++ + D + DN+ + S+ E
Sbjct: 1395 EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE 1454
Query: 830 SAGNMPRQL--EMGGLSP--AGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEE----EK 881
QL E +S A + +A A + ++ E KEE K
Sbjct: 1455 KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1514
Query: 882 IREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLK--------IKIKKE 933
+ + ++++ ++ N+ E LE+ +R LE +E K E L+ K++ E
Sbjct: 1515 MLKAEMEDLVSSKDDVGKNVHE-LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573
Query: 934 LEM-------ENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGS 986
+ M E +L+ +++ ++K + L +Y ++ E+ Q + ++KK + EG
Sbjct: 1574 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL-EGD 1632
Query: 987 LVDTLQSSD 995
L D +D
Sbjct: 1633 LKDLELQAD 1641
Score = 71.2 bits (173), Expect = 4e-12
Identities = 180/892 (20%), Positives = 341/892 (38%), Gaps = 165/892 (18%)
Query: 170 DSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAK 229
+ L L +DD+ A K LE +++ ++E L +E + K K
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISD----LQEDLDSERAARNKAEKQKRDLG 1152
Query: 230 IKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLE---RIHKHQEIETKEIYAQR 286
++EA K E E T+ ++ +AK E V K L+ R H+ Q E ++ +AQ
Sbjct: 1153 EELEALKT-ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211
Query: 287 -QLLLKDMDLLRGREAELKQRVEAFE------------LNQKLQEEKHKSITEALRRQEQ 333
+ L + ++ + +A L + + E L Q QE +HK + L Q Q
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK--KKLEAQVQ 1269
Query: 334 NIKSFEETYDR---KLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAIN 390
++S +R +L +++ K Q E++ T L E E K A+ L +++ +++
Sbjct: 1270 ELQSKCSDGERARAELNDKVHKLQNEVESV----TGMLNEAEGK----AIKLAKDVASLS 1321
Query: 391 SK--------KEELNQSVN---RVKELELELESVKAQ-----------SLAITKQNHMLN 428
S+ +EE Q +N ++++LE E S++ Q I+ N L+
Sbjct: 1322 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1381
Query: 429 EKVKEMSDYS----LLKEEKLELLAQNKLLKQQLEESRNENLRL---LNRLAQPAPELAV 481
+ K++ D++ L+E K + + L QQ EE +L NRL Q +L V
Sbjct: 1382 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441
Query: 482 -----------FQKELRKAEKAIVVEH--------------------------------- 497
+K+ RK ++ + E
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Query: 498 -----EEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTA 552
EE E + L +++D + + + + S ++L TQ+ ++K QL++
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE---- 1557
Query: 553 LENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYP 612
LE+E+ Q+ D + + N+ G+ D L +Q R + ++ Y
Sbjct: 1558 LEDEL-----QATEDAKLR--LEVNMQALKGQFERD-LQARDEQNEEKRRQLQRQLHEYE 1609
Query: 613 TAW----------------VEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRV 656
T +EG D +L+ + K R + ++Q +L+ + + R +
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMKDFQREL 1668
Query: 657 IKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEA 716
+ A++ E K S + ED +E+ + E+ ++ E
Sbjct: 1669 -----EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723
Query: 717 LTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPT 776
L S + R RRL + + + + LE E + DR+ +
Sbjct: 1724 LASSLSGRNALQDEKRRLEAR-IAQLEEELEEEQ----------GNMEAMSDRVRKATQQ 1772
Query: 777 ESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPR 836
+ S + S QK R+Q E Q+K S + ++ +F+S+ +
Sbjct: 1773 AEQLSNELATERSTA-QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1831
Query: 837 QLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREER 896
QLE A + A S + K+I Q E+E+ +Q KE+ ++
Sbjct: 1832 QLEEQVEQEAREKQ-------AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1884
Query: 897 RQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIK 948
R L+ LE E +++ R+ ++ L + M E+ +++
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 70.5 bits (171), Expect = 8e-12
Identities = 142/732 (19%), Positives = 289/732 (39%), Gaps = 92/732 (12%)
Query: 296 LRGREAEL---KQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLK 352
++ +E EL K+R + E K E+KH +TE ++ +++ E Y + E ++
Sbjct: 861 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY---AEAEEMR 917
Query: 353 YQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELES 412
+L K E E E L+EE + E + ++ +LE +LE
Sbjct: 918 VRLAAKKQ---------ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968
Query: 413 VKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLA-QNKLLKQQL---------EESR 462
+A + + K+K++ D L+ +++ L+ + KLL++++ EE +
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 463 NENL-RLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQL 521
+NL +L N+ EL V L+K EK+ +E E ++ L D E A L
Sbjct: 1029 AKNLTKLKNKHESMISELEV---RLKKEEKS----RQELEKLKRKLEGDASDFHEQIADL 1081
Query: 522 KAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPC 581
+AQI L Q+A + +L+ L++E+ R + G I+
Sbjct: 1082 QAQI-------AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 582 NGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQE 641
+ E + N KQ+ L + + T + L+ A + + +QE
Sbjct: 1135 DSERAA--RNKAEKQKRDLGEELEALKTEL----------EDTLDSTATQQELRAKREQE 1182
Query: 642 AERLEKAF----RSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNI---------TSSSPE 688
L+KA RS+ +V + K A + LE FK T
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEE--LTEQLEQFKRAKANLDKNKQTLEKEN 1240
Query: 689 RHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLES 748
+ GE RV+ + Q +E + +EA S+ G +R + + K + +ES
Sbjct: 1241 ADLAGELRVLGQAKQ--EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVES 1298
Query: 749 EMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKS 808
+ L + + D L S + L + QK+ + + +L+++
Sbjct: 1299 VTGM--LNEAEGKAIKLAKDVASLSSQLQDTQEL----LQEETRQKLNVSTKLRQLEEER 1352
Query: 809 EFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSV 868
++ + E+ N+ R + + + + A+ V +
Sbjct: 1353 N---------SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1403
Query: 869 DQKQIE---EQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEES 925
QK+IE +Q EE+ ++++ + R ++ +L L+ +R+ + L ++++ ++
Sbjct: 1404 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1463
Query: 926 LKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEG 985
L + + +E + + E ++K + + + ++ +++ E +K K
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK-----A 1518
Query: 986 SLVDTLQSSDKV 997
+ D + S D V
Sbjct: 1519 EMEDLVSSKDDV 1530
Score = 67.0 bits (162), Expect = 8e-11
Identities = 205/1069 (19%), Positives = 403/1069 (37%), Gaps = 120/1069 (11%)
Query: 14 LSQDELRKK--LYQTFKDRGILDTLKTQLRNQLIHELMHPVLSGELQPRSISVEGSSL-- 69
L Q++L+ + LY ++ + K Q +++HE+ + E + + + E +
Sbjct: 898 LLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQ 957
Query: 70 -LIGASNSLVADHLQRCGYEYSLSVFFPESGLAK--EKVFTMQDLLQLIKINPTSSLYKS 126
++ L + R + L E+ + K +++ M D Q K++ L +
Sbjct: 958 QMLDLEEQLEEEEAAR--QKLQLEKVTAEAKIKKLEDEILVMDD--QNNKLSKERKLLEE 1013
Query: 127 LVSGSD----KENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQ 182
+S +E +K + LK E ++ ++ + S + L KL+
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE----- 1068
Query: 183 FADAYPQRIKFESLEIKLNEYKREI---EEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYE 239
DA + L+ ++ E K ++ EE+L+A + + D EIA+ KK E
Sbjct: 1069 -GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL-----DDEIAQKNNALKKIRE 1122
Query: 240 KE--LTMFQNDF--EKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDL 295
E ++ Q D E+A + K+E LE + E Q++L K
Sbjct: 1123 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1182
Query: 296 LRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQL 355
+ + L + + E + +KH E L Q + K + D+ K L K
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN-KQTLEKENA 1241
Query: 356 ELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKA 415
+L + + E E K K+ +QE + + + ++V +L+ E+ESV
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301
Query: 416 QSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQP 475
MLNE + L ++ L +Q + ++ L+E + L + +L Q
Sbjct: 1302 ----------MLNEAEGKAIK---LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1348
Query: 476 APELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSL 535
E Q +L + +A + E L+ QL D + + + + K
Sbjct: 1349 EEERNSLQDQLDEEMEA----KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 536 TTQVADLKLQLKQTQTALEN-EVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPF 594
++ +L Q ++ A + E N Q +D V L N + N E +
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Query: 595 KQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHR 654
+E ++ A A E ++ +A E ++E ER K ++
Sbjct: 1465 AEEKNISSKYADERDR---AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME 1521
Query: 655 RVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDV- 713
++ S+K + ++H LE K + E + + E + R +V
Sbjct: 1522 DLV--SSKDDVGK----NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1575
Query: 714 VEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPC--PDRMP 771
++AL G L+ L + E+E+ E R+ A+ D
Sbjct: 1576 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635
Query: 772 LPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESA 831
L +S + + + + Q EL+D D K+NE+ S E A
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE-A 1694
Query: 832 GNMPRQLEMGGLSPAGDMSHVD----AAAAAVPLSYQHPSVDQK--------QIEEQKEE 879
M Q ++ A + ++ A A LS ++ D+K Q+EE+ EE
Sbjct: 1695 DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1754
Query: 880 EKIREQQVKER-----RQREE------------RRQSNLQEVLERERRELEKLYQERK-- 920
E+ + + +R +Q E+ ++ + ++ LER+ +EL E +
Sbjct: 1755 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1814
Query: 921 -----------------MIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMK 963
+EE ++ + +++ L+ ++++K+ E+ E+ M
Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED--ERKM- 1871
Query: 964 IIQQEQDQESADKSSKKMVQ-EGSLVDTLQSSDKVESLTGFSHEELDDS 1011
EQ +E A+K + ++ Q + L + + S ++ + ELD++
Sbjct: 1872 ---AEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1917
Score = 46.2 bits (108), Expect = 2e-04
Identities = 48/239 (20%), Positives = 104/239 (43%), Gaps = 18/239 (7%)
Query: 784 IPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNM-PRQLEMGG 842
+ P+ Q+ + ++ ELQ E + K+ E+ S N+ QL+
Sbjct: 848 VKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ--- 904
Query: 843 LSPAGDMSHVDAAAAAVPLSYQHPSVDQ--KQIEEQKEEEKIREQQVKERRQREERRQSN 900
A + +A V L+ + +++ ++E + EEE+ R QQ++ R++ ++ +
Sbjct: 905 ---AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961
Query: 901 LQEVLERERRELEKLYQER-------KMIEESLKIKIKKELEMENELEMSNQEIKDKSAH 953
L+E LE E +KL E+ K +E+ + + + ++ E ++ + I D + +
Sbjct: 962 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 954 SENPLEKYMKIIQQEQDQES--ADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEELDD 1010
EK + + + ES ++ + +E S + + K+E HE++ D
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 74.7 bits (182), Expect = 4e-13
Identities = 169/902 (18%), Positives = 352/902 (39%), Gaps = 100/902 (11%)
Query: 144 LKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEY 203
LKEL + H + T ++ L E+LQ + +A+A E + ++L
Sbjct: 882 LKELEQKH-----------SQLTEEKNLLQEQLQAETELYAEA-------EEMRVRLAAK 923
Query: 204 KREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLR 263
K+E+EE L EM +L+ +D +++ E KK ++ L D E+ + + A R
Sbjct: 924 KQELEEILH-EMEARLEEEEDRG-QQLQAERKKMAQQML-----DLEEQLEEEEAA---R 973
Query: 264 EKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAE-LKQRVEAFELNQKLQEEKHK 322
+K LE++ +I+ E L++ D + +E + L++R+ N +EEK K
Sbjct: 974 QKLQLEKVTAEAKIKKLE---DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1030
Query: 323 SITEALRRQEQNIKSFEETY--DRKLKNELLKYQLELKDD-------YIIRTNRLIEDER 373
++T+ + E I E + K + EL K + +L+ D ++ E +
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 374 KNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKE 433
+ +K LQ L ++ + + N ++ +++ELE + ++ + E
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ-------------EDLDSE 1137
Query: 434 MSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAI 493
+ + +++K +L + + LK +LE++ + A+ E+ V +K L + ++
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197
Query: 494 VVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVA-------DLKLQL 546
+ +E ++L +++E + KA + K +++ +A K ++
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257
Query: 547 KQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISG--DFLNNPFKQENVLARMV 604
+ + LE +V + +N V E+ LN + LA+ V
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 605 ASRITNYPTAWVEGSSPDSDLEFVANTKARVK-ELQQEAERLEKAFRSYHRRVIKNSAKS 663
AS SS D + + + R K + + +LE+ R +++
Sbjct: 1318 ASL-----------SSQLQDTQELLQEETRQKLNVSTKLRQLEE-----ERNSLQDQLDE 1361
Query: 664 PLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAAS 723
+ AK H+ ++ S + F E+ + +E ++ + AA+
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421
Query: 724 RLRGGTSSRRLSSTPLPKAKRSLESEMYL-EGLGRSHIASPSPCPDRMPLPSPTESRHSL 782
+ + RL L L+++ L L + + + S
Sbjct: 1422 YDKLEKTKNRLQQ-ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 783 SIPPVSSPPEQKVGLYRRQTE-LQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMG 841
+ + + L R E L+ K E +K+ + E+ SS + G +LE
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540
Query: 842 GLSPAGDMSHVDAAAAAVPLSYQ-------HPSVDQKQIEEQKEEE-KIREQQVKERRQR 893
+ M + + Q V+ + ++ Q E + + R++Q +E+R++
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1600
Query: 894 EERRQSNLQEVLERERRELEKLYQERKMIEESLK-------IKIKKELEMENELEMSNQE 946
+R+ + LE ER++ +K +E LK IK E +L +
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1660
Query: 947 IKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHE 1006
+KD E+ +I ++ E KS + + + L + L ++++ E
Sbjct: 1661 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ--LQEDLAAAERARKQADLEKE 1718
Query: 1007 EL 1008
EL
Sbjct: 1719 EL 1720
Score = 73.2 bits (178), Expect = 1e-12
Identities = 177/849 (20%), Positives = 340/849 (40%), Gaps = 98/849 (11%)
Query: 193 FESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKA 252
F ++ L ++E E Q + + QK K + + A+ +++ ++ +LT +N ++
Sbjct: 845 FTKVKPLLQVTRQEEEMQAKEDELQKTK--ERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 253 CQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRV-EAFE 311
QA++E E+ + K QE+E + ++ L ++ D + +AE K+ + +
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELE-EILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961
Query: 312 LNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIED 371
L ++L+EE EA R++ Q K E +KL++E+L + DD + N+L ++
Sbjct: 962 LEEQLEEE------EAARQKLQLEKVTAEAKIKKLEDEIL-----VMDD---QNNKLSKE 1007
Query: 372 ERKNKEKAVHLQEELIAINSKKEELNQSVNR----VKELELELESVKAQSLAITKQNHML 427
+ +E+ L L K + L + N+ + ELE+ L+ + + K L
Sbjct: 1008 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1067
Query: 428 NEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELR 487
D S E+ +L AQ LK QL + E L RL + K++R
Sbjct: 1068 E------GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1121
Query: 488 KAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLK 547
+ E I E+ +S R A +K + + + +L+A + ++ S TQ +L+ + +
Sbjct: 1122 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ-QELRAKRE 1180
Query: 548 QTQT----ALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARM 603
Q T AL+ E + Q R + + +Q R
Sbjct: 1181 QEVTVLKKALDEETRSHEAQVQEMRQKH---------------AQAVEELTEQLEQFKRA 1225
Query: 604 VASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKS 663
A+ N T E + +L + K V+ +++ E + +S K S
Sbjct: 1226 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS------KCSDGE 1279
Query: 664 PLAAKSPPSLHLLE-AFKNITSSSPERHIFGEDRVVSEQPQVGTLEER-NDVVEALTGSA 721
A+ +H L+ +++T E E + + V +L + D E L
Sbjct: 1280 RARAELNDKVHKLQNEVESVTGMLNE----AEGKAIKLAKDVASLSSQLQDTQELLQEET 1335
Query: 722 ASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIA--------SPSPCPDRMPLP 773
+L T R+L + L+ EM + HI+ S D
Sbjct: 1336 RQKLNVSTKLRQLEE-ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1394
Query: 774 SPTE---SRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNE-EFESSFE 829
E R I ++ E+K Y + + +++ + D + DN+ + S+ E
Sbjct: 1395 EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE 1454
Query: 830 SAGNMPRQL--EMGGLSP--AGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEE----EK 881
QL E +S A + +A A + ++ E KEE K
Sbjct: 1455 KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1514
Query: 882 IREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLK--------IKIKKE 933
+ + ++++ ++ N+ E LE+ +R LE +E K E L+ K++ E
Sbjct: 1515 MLKAEMEDLVSSKDDVGKNVHE-LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573
Query: 934 LEM-------ENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGS 986
+ M E +L+ +++ ++K + L +Y ++ E+ Q + ++KK + EG
Sbjct: 1574 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL-EGD 1632
Query: 987 LVDTLQSSD 995
L D +D
Sbjct: 1633 LKDLELQAD 1641
Score = 71.2 bits (173), Expect = 4e-12
Identities = 180/892 (20%), Positives = 341/892 (38%), Gaps = 165/892 (18%)
Query: 170 DSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAK 229
+ L L +DD+ A K LE +++ ++E L +E + K K
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISD----LQEDLDSERAARNKAEKQKRDLG 1152
Query: 230 IKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLE---RIHKHQEIETKEIYAQR 286
++EA K E E T+ ++ +AK E V K L+ R H+ Q E ++ +AQ
Sbjct: 1153 EELEALKT-ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211
Query: 287 -QLLLKDMDLLRGREAELKQRVEAFE------------LNQKLQEEKHKSITEALRRQEQ 333
+ L + ++ + +A L + + E L Q QE +HK + L Q Q
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK--KKLEAQVQ 1269
Query: 334 NIKSFEETYDR---KLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAIN 390
++S +R +L +++ K Q E++ T L E E K A+ L +++ +++
Sbjct: 1270 ELQSKCSDGERARAELNDKVHKLQNEVESV----TGMLNEAEGK----AIKLAKDVASLS 1321
Query: 391 SK--------KEELNQSVN---RVKELELELESVKAQ-----------SLAITKQNHMLN 428
S+ +EE Q +N ++++LE E S++ Q I+ N L+
Sbjct: 1322 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1381
Query: 429 EKVKEMSDYS----LLKEEKLELLAQNKLLKQQLEESRNENLRL---LNRLAQPAPELAV 481
+ K++ D++ L+E K + + L QQ EE +L NRL Q +L V
Sbjct: 1382 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441
Query: 482 -----------FQKELRKAEKAIVVEH--------------------------------- 497
+K+ RK ++ + E
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Query: 498 -----EEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTA 552
EE E + L +++D + + + + S ++L TQ+ ++K QL++
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE---- 1557
Query: 553 LENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYP 612
LE+E+ Q+ D + + N+ G+ D L +Q R + ++ Y
Sbjct: 1558 LEDEL-----QATEDAKLR--LEVNMQALKGQFERD-LQARDEQNEEKRRQLQRQLHEYE 1609
Query: 613 TAW----------------VEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRV 656
T +EG D +L+ + K R + ++Q +L+ + + R +
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMKDFQREL 1668
Query: 657 IKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEA 716
+ A++ E K S + ED +E+ + E+ ++ E
Sbjct: 1669 -----EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723
Query: 717 LTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPT 776
L S + R RRL + + + + LE E + DR+ +
Sbjct: 1724 LASSLSGRNALQDEKRRLEAR-IAQLEEELEEEQ----------GNMEAMSDRVRKATQQ 1772
Query: 777 ESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPR 836
+ S + S QK R+Q E Q+K S + ++ +F+S+ +
Sbjct: 1773 AEQLSNELATERSTA-QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1831
Query: 837 QLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREER 896
QLE A + A S + K+I Q E+E+ +Q KE+ ++
Sbjct: 1832 QLEEQVEQEAREKQ-------AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1884
Query: 897 RQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIK 948
R L+ LE E +++ R+ ++ L + M E+ +++
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 70.5 bits (171), Expect = 8e-12
Identities = 142/732 (19%), Positives = 289/732 (39%), Gaps = 92/732 (12%)
Query: 296 LRGREAEL---KQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLK 352
++ +E EL K+R + E K E+KH +TE ++ +++ E Y + E ++
Sbjct: 861 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY---AEAEEMR 917
Query: 353 YQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELES 412
+L K E E E L+EE + E + ++ +LE +LE
Sbjct: 918 VRLAAKKQ---------ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968
Query: 413 VKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLA-QNKLLKQQL---------EESR 462
+A + + K+K++ D L+ +++ L+ + KLL++++ EE +
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 463 NENL-RLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQL 521
+NL +L N+ EL V L+K EK+ +E E ++ L D E A L
Sbjct: 1029 AKNLTKLKNKHESMISELEV---RLKKEEKS----RQELEKLKRKLEGDASDFHEQIADL 1081
Query: 522 KAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPC 581
+AQI L Q+A + +L+ L++E+ R + G I+
Sbjct: 1082 QAQI-------AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 582 NGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQE 641
+ E + N KQ+ L + + T + L+ A + + +QE
Sbjct: 1135 DSERAA--RNKAEKQKRDLGEELEALKTEL----------EDTLDSTATQQELRAKREQE 1182
Query: 642 AERLEKAF----RSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNI---------TSSSPE 688
L+KA RS+ +V + K A + LE FK T
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEE--LTEQLEQFKRAKANLDKNKQTLEKEN 1240
Query: 689 RHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLES 748
+ GE RV+ + Q +E + +EA S+ G +R + + K + +ES
Sbjct: 1241 ADLAGELRVLGQAKQ--EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVES 1298
Query: 749 EMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKS 808
+ L + + D L S + L + QK+ + + +L+++
Sbjct: 1299 VTGM--LNEAEGKAIKLAKDVASLSSQLQDTQEL----LQEETRQKLNVSTKLRQLEEER 1352
Query: 809 EFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSV 868
++ + E+ N+ R + + + + A+ V +
Sbjct: 1353 N---------SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1403
Query: 869 DQKQIE---EQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEES 925
QK+IE +Q EE+ ++++ + R ++ +L L+ +R+ + L ++++ ++
Sbjct: 1404 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1463
Query: 926 LKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEG 985
L + + +E + + E ++K + + + ++ +++ E +K K
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK-----A 1518
Query: 986 SLVDTLQSSDKV 997
+ D + S D V
Sbjct: 1519 EMEDLVSSKDDV 1530
Score = 67.0 bits (162), Expect = 8e-11
Identities = 205/1069 (19%), Positives = 403/1069 (37%), Gaps = 120/1069 (11%)
Query: 14 LSQDELRKK--LYQTFKDRGILDTLKTQLRNQLIHELMHPVLSGELQPRSISVEGSSL-- 69
L Q++L+ + LY ++ + K Q +++HE+ + E + + + E +
Sbjct: 898 LLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQ 957
Query: 70 -LIGASNSLVADHLQRCGYEYSLSVFFPESGLAK--EKVFTMQDLLQLIKINPTSSLYKS 126
++ L + R + L E+ + K +++ M D Q K++ L +
Sbjct: 958 QMLDLEEQLEEEEAAR--QKLQLEKVTAEAKIKKLEDEILVMDD--QNNKLSKERKLLEE 1013
Query: 127 LVSGSD----KENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQ 182
+S +E +K + LK E ++ ++ + S + L KL+
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE----- 1068
Query: 183 FADAYPQRIKFESLEIKLNEYKREI---EEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYE 239
DA + L+ ++ E K ++ EE+L+A + + D EIA+ KK E
Sbjct: 1069 -GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL-----DDEIAQKNNALKKIRE 1122
Query: 240 KE--LTMFQNDF--EKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDL 295
E ++ Q D E+A + K+E LE + E Q++L K
Sbjct: 1123 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1182
Query: 296 LRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQL 355
+ + L + + E + +KH E L Q + K + D+ K L K
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN-KQTLEKENA 1241
Query: 356 ELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKA 415
+L + + E E K K+ +QE + + + ++V +L+ E+ESV
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301
Query: 416 QSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQP 475
MLNE + L ++ L +Q + ++ L+E + L + +L Q
Sbjct: 1302 ----------MLNEAEGKAIK---LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1348
Query: 476 APELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSL 535
E Q +L + +A + E L+ QL D + + + + K
Sbjct: 1349 EEERNSLQDQLDEEMEA----KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 536 TTQVADLKLQLKQTQTALEN-EVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPF 594
++ +L Q ++ A + E N Q +D V L N + N E +
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Query: 595 KQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHR 654
+E ++ A A E ++ +A E ++E ER K ++
Sbjct: 1465 AEEKNISSKYADERDR---AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME 1521
Query: 655 RVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDV- 713
++ S+K + ++H LE K + E + + E + R +V
Sbjct: 1522 DLV--SSKDDVGK----NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1575
Query: 714 VEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPC--PDRMP 771
++AL G L+ L + E+E+ E R+ A+ D
Sbjct: 1576 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635
Query: 772 LPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESA 831
L +S + + + + Q EL+D D K+NE+ S E A
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE-A 1694
Query: 832 GNMPRQLEMGGLSPAGDMSHVD----AAAAAVPLSYQHPSVDQK--------QIEEQKEE 879
M Q ++ A + ++ A A LS ++ D+K Q+EE+ EE
Sbjct: 1695 DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1754
Query: 880 EKIREQQVKER-----RQREE------------RRQSNLQEVLERERRELEKLYQERK-- 920
E+ + + +R +Q E+ ++ + ++ LER+ +EL E +
Sbjct: 1755 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1814
Query: 921 -----------------MIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMK 963
+EE ++ + +++ L+ ++++K+ E+ E+ M
Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED--ERKM- 1871
Query: 964 IIQQEQDQESADKSSKKMVQ-EGSLVDTLQSSDKVESLTGFSHEELDDS 1011
EQ +E A+K + ++ Q + L + + S ++ + ELD++
Sbjct: 1872 ---AEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1917
Score = 46.2 bits (108), Expect = 2e-04
Identities = 48/239 (20%), Positives = 104/239 (43%), Gaps = 18/239 (7%)
Query: 784 IPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNM-PRQLEMGG 842
+ P+ Q+ + ++ ELQ E + K+ E+ S N+ QL+
Sbjct: 848 VKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ--- 904
Query: 843 LSPAGDMSHVDAAAAAVPLSYQHPSVDQ--KQIEEQKEEEKIREQQVKERRQREERRQSN 900
A + +A V L+ + +++ ++E + EEE+ R QQ++ R++ ++ +
Sbjct: 905 ---AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961
Query: 901 LQEVLERERRELEKLYQER-------KMIEESLKIKIKKELEMENELEMSNQEIKDKSAH 953
L+E LE E +KL E+ K +E+ + + + ++ E ++ + I D + +
Sbjct: 962 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 954 SENPLEKYMKIIQQEQDQES--ADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEELDD 1010
EK + + + ES ++ + +E S + + K+E HE++ D
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 74.7 bits (182), Expect = 4e-13
Identities = 169/902 (18%), Positives = 352/902 (39%), Gaps = 100/902 (11%)
Query: 144 LKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEY 203
LKEL + H + T ++ L E+LQ + +A+A E + ++L
Sbjct: 875 LKELEQKH-----------SQLTEEKNLLQEQLQAETELYAEA-------EEMRVRLAAK 916
Query: 204 KREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLR 263
K+E+EE L EM +L+ +D +++ E KK ++ L D E+ + + A R
Sbjct: 917 KQELEEILH-EMEARLEEEEDRG-QQLQAERKKMAQQML-----DLEEQLEEEEAA---R 966
Query: 264 EKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAE-LKQRVEAFELNQKLQEEKHK 322
+K LE++ +I+ E L++ D + +E + L++R+ N +EEK K
Sbjct: 967 QKLQLEKVTAEAKIKKLE---DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1023
Query: 323 SITEALRRQEQNIKSFEETY--DRKLKNELLKYQLELKDD-------YIIRTNRLIEDER 373
++T+ + E I E + K + EL K + +L+ D ++ E +
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 374 KNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKE 433
+ +K LQ L ++ + + N ++ +++ELE + ++ + E
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ-------------EDLDSE 1130
Query: 434 MSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAI 493
+ + +++K +L + + LK +LE++ + A+ E+ V +K L + ++
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190
Query: 494 VVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVA-------DLKLQL 546
+ +E ++L +++E + KA + K +++ +A K ++
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250
Query: 547 KQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISG--DFLNNPFKQENVLARMV 604
+ + LE +V + +N V E+ LN + LA+ V
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 605 ASRITNYPTAWVEGSSPDSDLEFVANTKARVK-ELQQEAERLEKAFRSYHRRVIKNSAKS 663
AS SS D + + + R K + + +LE+ R +++
Sbjct: 1311 ASL-----------SSQLQDTQELLQEETRQKLNVSTKLRQLEE-----ERNSLQDQLDE 1354
Query: 664 PLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAAS 723
+ AK H+ ++ S + F E+ + +E ++ + AA+
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414
Query: 724 RLRGGTSSRRLSSTPLPKAKRSLESEMYL-EGLGRSHIASPSPCPDRMPLPSPTESRHSL 782
+ + RL L L+++ L L + + + S
Sbjct: 1415 YDKLEKTKNRLQQ-ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 783 SIPPVSSPPEQKVGLYRRQTE-LQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMG 841
+ + + L R E L+ K E +K+ + E+ SS + G +LE
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533
Query: 842 GLSPAGDMSHVDAAAAAVPLSYQ-------HPSVDQKQIEEQKEEE-KIREQQVKERRQR 893
+ M + + Q V+ + ++ Q E + + R++Q +E+R++
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1593
Query: 894 EERRQSNLQEVLERERRELEKLYQERKMIEESLK-------IKIKKELEMENELEMSNQE 946
+R+ + LE ER++ +K +E LK IK E +L +
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1653
Query: 947 IKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHE 1006
+KD E+ +I ++ E KS + + + L + L ++++ E
Sbjct: 1654 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ--LQEDLAAAERARKQADLEKE 1711
Query: 1007 EL 1008
EL
Sbjct: 1712 EL 1713
Score = 73.2 bits (178), Expect = 1e-12
Identities = 177/849 (20%), Positives = 340/849 (40%), Gaps = 98/849 (11%)
Query: 193 FESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKA 252
F ++ L ++E E Q + + QK K + + A+ +++ ++ +LT +N ++
Sbjct: 838 FTKVKPLLQVTRQEEEMQAKEDELQKTK--ERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 253 CQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRV-EAFE 311
QA++E E+ + K QE+E + ++ L ++ D + +AE K+ + +
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELE-EILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954
Query: 312 LNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIED 371
L ++L+EE EA R++ Q K E +KL++E+L + DD + N+L ++
Sbjct: 955 LEEQLEEE------EAARQKLQLEKVTAEAKIKKLEDEIL-----VMDD---QNNKLSKE 1000
Query: 372 ERKNKEKAVHLQEELIAINSKKEELNQSVNR----VKELELELESVKAQSLAITKQNHML 427
+ +E+ L L K + L + N+ + ELE+ L+ + + K L
Sbjct: 1001 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1060
Query: 428 NEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELR 487
D S E+ +L AQ LK QL + E L RL + K++R
Sbjct: 1061 E------GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1114
Query: 488 KAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLK 547
+ E I E+ +S R A +K + + + +L+A + ++ S TQ +L+ + +
Sbjct: 1115 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ-QELRAKRE 1173
Query: 548 QTQT----ALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARM 603
Q T AL+ E + Q R + + +Q R
Sbjct: 1174 QEVTVLKKALDEETRSHEAQVQEMRQKH---------------AQAVEELTEQLEQFKRA 1218
Query: 604 VASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKS 663
A+ N T E + +L + K V+ +++ E + +S K S
Sbjct: 1219 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS------KCSDGE 1272
Query: 664 PLAAKSPPSLHLLE-AFKNITSSSPERHIFGEDRVVSEQPQVGTLEER-NDVVEALTGSA 721
A+ +H L+ +++T E E + + V +L + D E L
Sbjct: 1273 RARAELNDKVHKLQNEVESVTGMLNE----AEGKAIKLAKDVASLSSQLQDTQELLQEET 1328
Query: 722 ASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIA--------SPSPCPDRMPLP 773
+L T R+L + L+ EM + HI+ S D
Sbjct: 1329 RQKLNVSTKLRQLEE-ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1387
Query: 774 SPTE---SRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNE-EFESSFE 829
E R I ++ E+K Y + + +++ + D + DN+ + S+ E
Sbjct: 1388 EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE 1447
Query: 830 SAGNMPRQL--EMGGLSP--AGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEE----EK 881
QL E +S A + +A A + ++ E KEE K
Sbjct: 1448 KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1507
Query: 882 IREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLK--------IKIKKE 933
+ + ++++ ++ N+ E LE+ +R LE +E K E L+ K++ E
Sbjct: 1508 MLKAEMEDLVSSKDDVGKNVHE-LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566
Query: 934 LEM-------ENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGS 986
+ M E +L+ +++ ++K + L +Y ++ E+ Q + ++KK + EG
Sbjct: 1567 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL-EGD 1625
Query: 987 LVDTLQSSD 995
L D +D
Sbjct: 1626 LKDLELQAD 1634
Score = 71.2 bits (173), Expect = 4e-12
Identities = 180/892 (20%), Positives = 341/892 (38%), Gaps = 165/892 (18%)
Query: 170 DSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAK 229
+ L L +DD+ A K LE +++ ++E L +E + K K
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISD----LQEDLDSERAARNKAEKQKRDLG 1145
Query: 230 IKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLE---RIHKHQEIETKEIYAQR 286
++EA K E E T+ ++ +AK E V K L+ R H+ Q E ++ +AQ
Sbjct: 1146 EELEALKT-ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204
Query: 287 -QLLLKDMDLLRGREAELKQRVEAFE------------LNQKLQEEKHKSITEALRRQEQ 333
+ L + ++ + +A L + + E L Q QE +HK + L Q Q
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK--KKLEAQVQ 1262
Query: 334 NIKSFEETYDR---KLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAIN 390
++S +R +L +++ K Q E++ T L E E K A+ L +++ +++
Sbjct: 1263 ELQSKCSDGERARAELNDKVHKLQNEVESV----TGMLNEAEGK----AIKLAKDVASLS 1314
Query: 391 SK--------KEELNQSVN---RVKELELELESVKAQ-----------SLAITKQNHMLN 428
S+ +EE Q +N ++++LE E S++ Q I+ N L+
Sbjct: 1315 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1374
Query: 429 EKVKEMSDYS----LLKEEKLELLAQNKLLKQQLEESRNENLRL---LNRLAQPAPELAV 481
+ K++ D++ L+E K + + L QQ EE +L NRL Q +L V
Sbjct: 1375 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1434
Query: 482 -----------FQKELRKAEKAIVVEH--------------------------------- 497
+K+ RK ++ + E
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 498 -----EEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTA 552
EE E + L +++D + + + + S ++L TQ+ ++K QL++
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE---- 1550
Query: 553 LENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYP 612
LE+E+ Q+ D + + N+ G+ D L +Q R + ++ Y
Sbjct: 1551 LEDEL-----QATEDAKLR--LEVNMQALKGQFERD-LQARDEQNEEKRRQLQRQLHEYE 1602
Query: 613 TAW----------------VEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRV 656
T +EG D +L+ + K R + ++Q +L+ + + R +
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMKDFQREL 1661
Query: 657 IKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEA 716
+ A++ E K S + ED +E+ + E+ ++ E
Sbjct: 1662 -----EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716
Query: 717 LTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPT 776
L S + R RRL + + + + LE E + DR+ +
Sbjct: 1717 LASSLSGRNALQDEKRRLEAR-IAQLEEELEEEQ----------GNMEAMSDRVRKATQQ 1765
Query: 777 ESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPR 836
+ S + S QK R+Q E Q+K S + ++ +F+S+ +
Sbjct: 1766 AEQLSNELATERSTA-QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1824
Query: 837 QLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREER 896
QLE A + A S + K+I Q E+E+ +Q KE+ ++
Sbjct: 1825 QLEEQVEQEAREKQ-------AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1877
Query: 897 RQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIK 948
R L+ LE E +++ R+ ++ L + M E+ +++
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 70.5 bits (171), Expect = 8e-12
Identities = 142/732 (19%), Positives = 289/732 (39%), Gaps = 92/732 (12%)
Query: 296 LRGREAEL---KQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLK 352
++ +E EL K+R + E K E+KH +TE ++ +++ E Y + E ++
Sbjct: 854 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY---AEAEEMR 910
Query: 353 YQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELES 412
+L K E E E L+EE + E + ++ +LE +LE
Sbjct: 911 VRLAAKKQ---------ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961
Query: 413 VKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLA-QNKLLKQQL---------EESR 462
+A + + K+K++ D L+ +++ L+ + KLL++++ EE +
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 463 NENL-RLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQL 521
+NL +L N+ EL V L+K EK+ +E E ++ L D E A L
Sbjct: 1022 AKNLTKLKNKHESMISELEV---RLKKEEKS----RQELEKLKRKLEGDASDFHEQIADL 1074
Query: 522 KAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPC 581
+AQI L Q+A + +L+ L++E+ R + G I+
Sbjct: 1075 QAQI-------AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 582 NGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQE 641
+ E + N KQ+ L + + T + L+ A + + +QE
Sbjct: 1128 DSERAA--RNKAEKQKRDLGEELEALKTEL----------EDTLDSTATQQELRAKREQE 1175
Query: 642 AERLEKAF----RSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNI---------TSSSPE 688
L+KA RS+ +V + K A + LE FK T
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEE--LTEQLEQFKRAKANLDKNKQTLEKEN 1233
Query: 689 RHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLES 748
+ GE RV+ + Q +E + +EA S+ G +R + + K + +ES
Sbjct: 1234 ADLAGELRVLGQAKQ--EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVES 1291
Query: 749 EMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKS 808
+ L + + D L S + L + QK+ + + +L+++
Sbjct: 1292 VTGM--LNEAEGKAIKLAKDVASLSSQLQDTQEL----LQEETRQKLNVSTKLRQLEEER 1345
Query: 809 EFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSV 868
++ + E+ N+ R + + + + A+ V +
Sbjct: 1346 N---------SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1396
Query: 869 DQKQIE---EQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEES 925
QK+IE +Q EE+ ++++ + R ++ +L L+ +R+ + L ++++ ++
Sbjct: 1397 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL 1456
Query: 926 LKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEG 985
L + + +E + + E ++K + + + ++ +++ E +K K
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK-----A 1511
Query: 986 SLVDTLQSSDKV 997
+ D + S D V
Sbjct: 1512 EMEDLVSSKDDV 1523
Score = 67.0 bits (162), Expect = 8e-11
Identities = 205/1069 (19%), Positives = 403/1069 (37%), Gaps = 120/1069 (11%)
Query: 14 LSQDELRKK--LYQTFKDRGILDTLKTQLRNQLIHELMHPVLSGELQPRSISVEGSSL-- 69
L Q++L+ + LY ++ + K Q +++HE+ + E + + + E +
Sbjct: 891 LLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQ 950
Query: 70 -LIGASNSLVADHLQRCGYEYSLSVFFPESGLAK--EKVFTMQDLLQLIKINPTSSLYKS 126
++ L + R + L E+ + K +++ M D Q K++ L +
Sbjct: 951 QMLDLEEQLEEEEAAR--QKLQLEKVTAEAKIKKLEDEILVMDD--QNNKLSKERKLLEE 1006
Query: 127 LVSGSD----KENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQ 182
+S +E +K + LK E ++ ++ + S + L KL+
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE----- 1061
Query: 183 FADAYPQRIKFESLEIKLNEYKREI---EEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYE 239
DA + L+ ++ E K ++ EE+L+A + + D EIA+ KK E
Sbjct: 1062 -GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL-----DDEIAQKNNALKKIRE 1115
Query: 240 KE--LTMFQNDF--EKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDL 295
E ++ Q D E+A + K+E LE + E Q++L K
Sbjct: 1116 LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQE 1175
Query: 296 LRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQL 355
+ + L + + E + +KH E L Q + K + D+ K L K
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN-KQTLEKENA 1234
Query: 356 ELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKA 415
+L + + E E K K+ +QE + + + ++V +L+ E+ESV
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294
Query: 416 QSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQP 475
MLNE + L ++ L +Q + ++ L+E + L + +L Q
Sbjct: 1295 ----------MLNEAEGKAIK---LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1341
Query: 476 APELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSL 535
E Q +L + +A + E L+ QL D + + + + K
Sbjct: 1342 EEERNSLQDQLDEEMEA----KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 536 TTQVADLKLQLKQTQTALEN-EVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPF 594
++ +L Q ++ A + E N Q +D V L N + N E +
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Query: 595 KQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHR 654
+E ++ A A E ++ +A E ++E ER K ++
Sbjct: 1458 AEEKNISSKYADERDR---AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME 1514
Query: 655 RVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDV- 713
++ S+K + ++H LE K + E + + E + R +V
Sbjct: 1515 DLV--SSKDDVGK----NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1568
Query: 714 VEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPC--PDRMP 771
++AL G L+ L + E+E+ E R+ A+ D
Sbjct: 1569 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628
Query: 772 LPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESA 831
L +S + + + + Q EL+D D K+NE+ S E A
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE-A 1687
Query: 832 GNMPRQLEMGGLSPAGDMSHVD----AAAAAVPLSYQHPSVDQK--------QIEEQKEE 879
M Q ++ A + ++ A A LS ++ D+K Q+EE+ EE
Sbjct: 1688 DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1747
Query: 880 EKIREQQVKER-----RQREE------------RRQSNLQEVLERERRELEKLYQERK-- 920
E+ + + +R +Q E+ ++ + ++ LER+ +EL E +
Sbjct: 1748 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1807
Query: 921 -----------------MIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMK 963
+EE ++ + +++ L+ ++++K+ E+ E+ M
Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED--ERKM- 1864
Query: 964 IIQQEQDQESADKSSKKMVQ-EGSLVDTLQSSDKVESLTGFSHEELDDS 1011
EQ +E A+K + ++ Q + L + + S ++ + ELD++
Sbjct: 1865 ---AEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1910
Score = 46.2 bits (108), Expect = 2e-04
Identities = 48/239 (20%), Positives = 104/239 (43%), Gaps = 18/239 (7%)
Query: 784 IPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNM-PRQLEMGG 842
+ P+ Q+ + ++ ELQ E + K+ E+ S N+ QL+
Sbjct: 841 VKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ--- 897
Query: 843 LSPAGDMSHVDAAAAAVPLSYQHPSVDQ--KQIEEQKEEEKIREQQVKERRQREERRQSN 900
A + +A V L+ + +++ ++E + EEE+ R QQ++ R++ ++ +
Sbjct: 898 ---AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954
Query: 901 LQEVLERERRELEKLYQER-------KMIEESLKIKIKKELEMENELEMSNQEIKDKSAH 953
L+E LE E +KL E+ K +E+ + + + ++ E ++ + I D + +
Sbjct: 955 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 954 SENPLEKYMKIIQQEQDQES--ADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEELDD 1010
EK + + + ES ++ + +E S + + K+E HE++ D
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 74.7 bits (182), Expect = 4e-13
Identities = 170/889 (19%), Positives = 343/889 (38%), Gaps = 120/889 (13%)
Query: 160 ETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKL 219
ET T + +L E Q D + +IKL + ++E L Q+
Sbjct: 991 ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLE----QEK 1046
Query: 220 KFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIET 279
K D E AK K+E K +E TM D E Q E L +K E +IE
Sbjct: 1047 KIRMDLERAKRKLEGDLKLAQESTM---DIENDKQQLDEKL---KKKEFEMSGLQSKIED 1100
Query: 280 KEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIK--- 336
++ + L K + L+ R EL++ +EA ++ E++ ++ L + ++
Sbjct: 1101 EQALGMQ--LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG 1158
Query: 337 ---SFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKK 393
S + ++K + E K + +L++ + +K+ + L E++ + K
Sbjct: 1159 GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVK 1218
Query: 394 EELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVK----EMSDYSLLKEEKLELLA 449
++L + + E+++E++ + + ++K L + + ++S+ +EE+ L+
Sbjct: 1219 QKLEKEKS---EMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLIN 1275
Query: 450 QNKLLKQQLEESRNENLRLLNRLAQPAPELA----VFQKELRKAEKAIVVEHEEFESCRQ 505
+ +L+ E R L+ +L+ F +++ + ++ + E + +
Sbjct: 1276 DLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAH 1335
Query: 506 ALHKQ------LQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYC 559
AL L+++ E + KA++ + ++ ++VA + + +T E
Sbjct: 1336 ALQSSRHDCDLLREQYEEEQEAKAEL---QRAMSKANSEVAQWRTKY-ETDAIQRTEELE 1391
Query: 560 NPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGS 619
K+ + R + +V N + + Q V M+ TN A ++
Sbjct: 1392 EAKKKLAQRLQDA--EEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKK 1449
Query: 620 SPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRV--IKNSAKSPLAAKSPPSLHLLE 677
+ D + +A K + +E E E +K RS + IKN+ + SL LE
Sbjct: 1450 QRNFD-KILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEE--------SLDQLE 1500
Query: 678 AFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSST 737
K + + +++ ++ LE+ VE S L+
Sbjct: 1501 TLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVE----QEKSELQAA--------- 1547
Query: 738 PLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGL 797
L +A+ SLE E EG R L + V S ++K+
Sbjct: 1548 -LEEAEASLEHE---EG---------------------KILRIQLELNQVKSEVDRKIAE 1582
Query: 798 YRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAA 857
+ + ++ V+ + + E S A + +++E ++H + AA
Sbjct: 1583 KDEEIDQMKRNHIRIVESMQSTLDAEIRSR-NDAIRLKKKMEGDLNEMEIQLNHANRMAA 1641
Query: 858 AVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQ 917
+Y++ K + ++ ++ +KE+ ERR + LQ +E R LE+ +
Sbjct: 1642 EALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTER 1701
Query: 918 ERKMIEESL----------------KIKIKKELEMENELEMSNQEIKDKSAHSENPLEKY 961
RK+ E+ L I KK+L E ++ E++D + N EK
Sbjct: 1702 SRKIAEQELLDASERVQLLHTQNTSLINTKKKL--ETDISQIQGEMEDIIQEARNAEEKA 1759
Query: 962 MKII----------QQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESL 1000
K I ++EQD + + KK +++ ++ D D+ E L
Sbjct: 1760 KKAITDAAMMAEELKKEQDTSAHLERMKKNLEQ-TVKDLQHRLDEAEQL 1807
Score = 74.7 bits (182), Expect = 4e-13
Identities = 179/883 (20%), Positives = 343/883 (38%), Gaps = 147/883 (16%)
Query: 145 KELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYK 204
+EL E + E T N+ AE ++ D +L K +
Sbjct: 1145 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1204
Query: 205 REIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEAL--VL 262
E+ EQ+ K K K+ K++++ + ++ + + EK C+A + L +
Sbjct: 1205 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIK 1264
Query: 263 REKSTLERI-----HKHQEIETKEIYAQRQLLLKDM---DLLRGREAELKQRVEAFELNQ 314
++ +R+ + ++T+ RQL KD L RG++A Q++E EL +
Sbjct: 1265 TKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQA-FTQQIE--ELKR 1321
Query: 315 KLQEE-KHKS-ITEALRRQEQNIKSFEETYDR-------------KLKNELLKYQLELKD 359
+L+EE K KS + AL+ + E Y+ K +E+ +++ + +
Sbjct: 1322 QLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYET 1381
Query: 360 DYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSV----NRVKELELELESVKA 415
D I RT L E ++K ++ +E + A+N+K L ++ N V++L +++E A
Sbjct: 1382 DAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNA 1441
Query: 416 QSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNK--------LLK---------QQL 458
A+ K+ ++ + E +E EL A K L K QL
Sbjct: 1442 ACAALDKKQRNFDKILAEWKQKC--EETHAELEASQKESRSLSTELFKIKNAYEESLDQL 1499
Query: 459 EESRNENLRLLNRLAQPAPELAVFQK---ELRKAEKAIVVEHEEFESCRQALHKQLQDEI 515
E + EN L ++ ++A K EL K +K + E E ++ + L+ E
Sbjct: 1500 ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEE 1559
Query: 516 EHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLIN 575
+++ ++ K+ V + + Q+K+ + + QS +D +
Sbjct: 1560 GKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESM-----QSTLDAEIRS--R 1612
Query: 576 GNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARV 635
+ + ++ GD LN Q N RM A + NY NT+A +
Sbjct: 1613 NDAIRLKKKMEGD-LNEMEIQLNHANRMAAEALRNY-----------------RNTQAIL 1654
Query: 636 KELQQEAERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGED 695
K+ Q L+ A RS + K LA ++E N+ + E E
Sbjct: 1655 KDTQL---HLDDALRS------QEDLKEQLA--------MVERRANLLQAEIE-----EL 1692
Query: 696 RVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEM-YLEG 754
R EQ E + E A+ R++ +T L K+ LE+++ ++G
Sbjct: 1693 RATLEQ-----TERSRKIAEQELLDASERVQ----LLHTQNTSLINTKKKLETDISQIQG 1743
Query: 755 LGRSHIASPSPCPD--RMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSD 812
I + + + L +S +++ QT + +
Sbjct: 1744 EMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE 1803
Query: 813 VDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQ 872
++LA K ++ E+ R E+ G + +V+A
Sbjct: 1804 AEQLALKGGKKQIQKLEA-----RVRELEGEVESEQKRNVEAVKGL-------------- 1844
Query: 873 IEEQKEEEKIREQQVKERRQREERRQS--NLQEVLERERRELEKLYQERKMIEESLKIKI 930
+K E K++E Q EE R++ LQ+++++ + +++ ++ + EE + +
Sbjct: 1845 ---RKHERKVKELTY----QTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNL 1897
Query: 931 KKELEMENELEMSNQEIKDKSAHSENPL-----EKYMKIIQQE 968
K +++ELE + +E D + N L E + KII +E
Sbjct: 1898 SKFRRIQHELEEA-EERADIAESQVNKLRVKSREVHTKIISEE 1939
Score = 61.2 bits (147), Expect = 5e-09
Identities = 159/794 (20%), Positives = 308/794 (38%), Gaps = 110/794 (13%)
Query: 239 EKELTMFQNDFEKACQ--AKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLL 296
EKE+ + +FEK + AK+EA K +E+E K + L+ + DL
Sbjct: 850 EKEMANMKEEFEKTKEELAKTEA-------------KRKELEEKMV----TLMQEKNDLQ 892
Query: 297 RGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLE 356
+AE +A EE+ + + + E IK E +R E + +L
Sbjct: 893 LQVQAEADSLADA--------EERCDQLIKTKIQLEAKIK---EVTERAEDEEEINAELT 941
Query: 357 LKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQ 416
K R +EDE +K + E +A K++ + N+VK L E+ +
Sbjct: 942 AK-------KRKLEDECSELKKDIDDLELTLAKVEKEKHATE--NKVKNLTEEMAGLDET 992
Query: 417 SLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKL-LKQQLEESRNENLRLLNRLAQP 475
+TK+ L E ++ D +E+K+ L + K+ L+QQ+++ L L Q
Sbjct: 993 IAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDD-------LEGSLEQE 1045
Query: 476 APELAVFQKELRKAEKAIVVEHE---EFESCRQALHKQLQDEIEHSAQLKAQILGYKASV 532
++ RK E + + E + E+ +Q L ++L+ + + L+++I +A
Sbjct: 1046 KKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALG 1105
Query: 533 KSLTTQVADLKLQLKQTQTALENE----VYCNPKQSVIDRSVNGLINGNVVPCNGEISGD 588
L ++ +L+ ++++ + +E E ++S + R + I+ + G S
Sbjct: 1106 MQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE-ISERLEEAGGATSAQ 1164
Query: 589 FLNNPFKQENVLARMVASRITNYPTAWVEGSSP---DSDLEFVANTKARVKELQQEAERL 645
N K+E +M R T E ++ + VA ++ LQ+ ++L
Sbjct: 1165 IEMNK-KREAEFQKM--RRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKL 1221
Query: 646 EKAFRSYHRRVIKNSAKSPLAAKSPPSLH-----LLEAFKNITSSSPERHIFGEDRVVSE 700
EK + ++ +K+ +L L + I + E+ D
Sbjct: 1222 EKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQR 1281
Query: 701 ---QPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGR 757
Q + G + D + L S+L G ++ + + + KR LE E+ +
Sbjct: 1282 ARLQTESGEYSRQLDEKDTL----VSQLSRG---KQAFTQQIEELKRQLEEEIKAKSALA 1334
Query: 758 SHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTE---LQDKSEFSDVD 814
+ S D + E + S +V +R + E +Q E +
Sbjct: 1335 HALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAK 1394
Query: 815 KLAFKDNEEFESSFESAGNMPRQLEMGGLSPAG-------DMSHVDAAAAAVPLSYQHPS 867
K + ++ E E+ LE D+ +AA AA L + +
Sbjct: 1395 KKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAA--LDKKQRN 1452
Query: 868 VDQKQIE-EQKEEEKIREQQVKERRQRE-ERRQSNLQEVLERERRELEKLYQERKMIEES 925
D+ E +QK EE E + ++ R ++ E +LE L +E K +++
Sbjct: 1453 FDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQE 1512
Query: 926 LK----------------IKIKKELEME-NELEMSNQEIKDKSAHSENP---LEKYMKII 965
+ KIKK++E E +EL+ + +E + H E ++ + +
Sbjct: 1513 ISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQV 1572
Query: 966 QQEQDQESADKSSK 979
+ E D++ A+K +
Sbjct: 1573 KSEVDRKIAEKDEE 1586
Score = 38.9 bits (89), Expect = 0.025
Identities = 106/577 (18%), Positives = 229/577 (39%), Gaps = 52/577 (9%)
Query: 458 LEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEH 517
LEE R+E L L Q A+ + L + E +VE E C Q + + ++H
Sbjct: 777 LEEMRDEKLAQLITRTQ-----AMCRGFLARVEYQKMVERRESIFCIQYNVRAFMN-VKH 830
Query: 518 SAQLKAQILGYKASVKSLTTQ--VADLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLIN 575
+K K +KS T+ +A++K + ++T+ L ++ + ++ V +
Sbjct: 831 WPWMKLYFK-IKPLLKSAETEKEMANMKEEFEKTKEELAKTEA--KRKELEEKMVTLMQE 887
Query: 576 GNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARV 635
N + + D L + E +++ ++I + + E A A+
Sbjct: 888 KNDLQLQVQAEADSLADA---EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKK 944
Query: 636 KELQQEAERLEKAFRSYHRRVIK-----NSAKSPLAAKSPPSLHLLEAFKNITSSSP--- 687
++L+ E L+K + K ++ ++ + + L E +T
Sbjct: 945 RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ 1004
Query: 688 ERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLE 747
E H D + +E+ +V TL + +E L G + L +AKR LE
Sbjct: 1005 EAHQQTLDDLQAEEDKVNTLTKAKIKLE----QQVDDLEGSLEQEKKIRMDLERAKRKLE 1060
Query: 748 SEMYLEGLGRSHIASPSPCPDRMPLPSPTESRH-SLSIPPVSSPPEQKVGLYRRQTELQD 806
++ L I + D+ L + + +S EQ +G+ ++ +
Sbjct: 1061 GDLKLAQESTMDIEN-----DKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKEL 1115
Query: 807 KSEFSDVDKLAFKDNEEFESSFESAGNMPRQLE--MGGLSPAGDMSHVDAAAAAVPLSYQ 864
++ ++++ + + + ++ R+LE L AG A +A + ++ +
Sbjct: 1116 QARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGG-----ATSAQIEMNKK 1170
Query: 865 HPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEV---LERERRELEKLYQERKM 921
+ QK + +E E R++ + L E L+R +++LEK E KM
Sbjct: 1171 REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKM 1230
Query: 922 IEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKII-----QQEQDQESADK 976
+ L ++ + + LE + ++D+ + + E+ ++I Q+ + Q + +
Sbjct: 1231 EIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGE 1290
Query: 977 SSKKMVQEGSLVDTLQS-----SDKVESLTGFSHEEL 1008
S+++ ++ +LV L + ++E L EE+
Sbjct: 1291 YSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEI 1327
Score = 33.1 bits (74), Expect = 1.4
Identities = 41/203 (20%), Positives = 80/203 (39%), Gaps = 18/203 (8%)
Query: 822 EEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQH--PSVDQKQIEEQKEE 879
++ E S E + LE GD+ + + Q + +K+ E +
Sbjct: 1036 DDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQ 1095
Query: 880 EKIREQQ-----VKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKEL 934
KI ++Q ++++ + + R L+E +E ER K ++R + L+ +I + L
Sbjct: 1096 SKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELE-EISERL 1154
Query: 935 EMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESA------DKSSKKMVQEGSLV 988
E + E+ K E +K + +++ Q A K + + + G +
Sbjct: 1155 EEAGGATSAQIEMNKK---REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQI 1211
Query: 989 DTLQS-SDKVESLTGFSHEELDD 1010
D LQ K+E E+DD
Sbjct: 1212 DNLQRVKQKLEKEKSEMKMEIDD 1234
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 74.3 bits (181), Expect = 5e-13
Identities = 91/455 (20%), Positives = 197/455 (43%), Gaps = 42/455 (9%)
Query: 102 KEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMET 161
KEK +Q+ LQL++ + E K L + H KE ++
Sbjct: 281 KEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA 340
Query: 162 QTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKF 221
+ + + L +L Q + Q K + E K+ E + +I EQ Q+ K
Sbjct: 341 KLQAQVEENELWNRLN--QQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKM 398
Query: 222 FKDTEIA-----KIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREK----------- 265
+ E+ K++ + + +EKE M + + E + + + L EK
Sbjct: 399 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQE-EMMWEKEEKIRELEEKMHEQEKIREQE 457
Query: 266 ------STLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEE 319
+ K QE E K ++ Q + + + + +R +E ++ ++ E +K++EE
Sbjct: 458 EKRQEEEKIREQEKRQEQEAK-MWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREE 516
Query: 320 KHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDER---KNK 376
+ + E + RQE+ I+ EE + +K K + ++ +++ + R + D+ + +
Sbjct: 517 EKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQ 576
Query: 377 EKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHML---NEKVKE 433
E+ V QEE I ++E++ + +++E E E + Q + +Q + EK++E
Sbjct: 577 EEKVWRQEE--KIREQEEKIREQEEKIREQE---EMTQEQEEKMGEQEEKMCEQEEKMQE 631
Query: 434 MSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLL---NRLAQPAPELAVFQKELRKAE 490
+ +EEK+ Q K +++Q E+ R + + ++ + ++ ++++++ E
Sbjct: 632 QEEKMRRQEEKIR--EQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE 689
Query: 491 KAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQI 525
+ + + E+ L +Q + EH L+A I
Sbjct: 690 EKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 724
Score = 53.1 bits (126), Expect = 1e-06
Identities = 41/133 (30%), Positives = 74/133 (55%), Gaps = 17/133 (12%)
Query: 869 DQKQIEEQKE-----EEKIREQQVKERRQREER--RQSNLQEVLERERRELEKL-YQERK 920
+Q++I QKE EEKIR+Q+ K RQ E+ ++ ++E E+ R+ EK+ QE K
Sbjct: 534 EQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEK 593
Query: 921 MIEESLKIKIKKELEMENELEMSNQEIK-----DKSAHSENPLEKYMKIIQQEQ----DQ 971
+ E+ KI+ ++E+ E E +M QE K +K E + + + I++++ +Q
Sbjct: 594 IREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQ 653
Query: 972 ESADKSSKKMVQE 984
E + ++M+QE
Sbjct: 654 EEKIREQEEMMQE 666
Score = 52.4 bits (124), Expect = 2e-06
Identities = 37/127 (29%), Positives = 73/127 (57%), Gaps = 15/127 (11%)
Query: 870 QKQIEEQKEEEKIREQQVKERRQREE----RRQSNLQEVLERERRELEKLYQERKMIEES 925
++Q E+++EEEKIREQ E+RQ +E R++ ++E E+ R + EK++++ + I E
Sbjct: 454 REQEEKRQEEEKIREQ---EKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQ 510
Query: 926 LKIKIKKELEMENELEMSNQEIKDKS---AHSENPLEKYMKIIQQE-----QDQESADKS 977
KI+ +++ + + E+ ++I+++ E E+ KI +QE Q+++ D+
Sbjct: 511 EKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQE 570
Query: 978 SKKMVQE 984
K QE
Sbjct: 571 EKIREQE 577
Score = 50.8 bits (120), Expect = 6e-06
Identities = 39/134 (29%), Positives = 73/134 (54%), Gaps = 14/134 (10%)
Query: 864 QHPSVDQKQIEEQKEEEKIREQQVKERRQREE---------RRQSNLQEVLERERRELEK 914
Q + +++ + +++EEKIREQ+ + Q E+ ++ +QE E+ RR+ EK
Sbjct: 583 QEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEK 642
Query: 915 L-YQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQ---D 970
+ QE+K+ E+ KI+ ++E+ E E +M QE K E E+ K+ +QE+ +
Sbjct: 643 IREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEK-MCEQEEKMQEQEEKMRRQEEKMWE 701
Query: 971 QESADKSSKKMVQE 984
QE + ++ +QE
Sbjct: 702 QEVRLRQQEEKMQE 715
Score = 48.9 bits (115), Expect = 2e-05
Identities = 38/116 (32%), Positives = 62/116 (53%), Gaps = 6/116 (5%)
Query: 864 QHPSVDQKQIEEQKEEEKIREQQVKERRQREE--RRQSNLQEVLERERRELEKLYQ-ERK 920
Q + + + + Q++EEKIREQ+ K R Q E+ R++ + E E+ RR+ E +++ E K
Sbjct: 366 QEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 425
Query: 921 MIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADK 976
M + + K+E E E +M QE K E ++ KI +QE+ QE K
Sbjct: 426 MRRQEEMMWEKEEKIRELEEKMHEQE---KIREQEEKRQEEEKIREQEKRQEQEAK 478
Score = 48.5 bits (114), Expect = 3e-05
Identities = 39/124 (31%), Positives = 69/124 (55%), Gaps = 12/124 (9%)
Query: 870 QKQIEEQKE-----EEKIREQQ-VKERRQREERRQSNLQEVLERERRELEKLYQERKMIE 923
+++I EQ+E EEKI EQ+ ++E +R+E+ + QE RE+ E+ + Q+ K+ E
Sbjct: 490 EEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWR--QKEKIHE 547
Query: 924 ESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQ---DQESADKSSKK 980
+ KI+ ++E E +M +QE K + E + KI +QE+ +QE + ++
Sbjct: 548 QEEKIRKQEEKMWRQEEKMHDQEEKIRE-QEEKVWRQEEKIREQEEKIREQEEKIREQEE 606
Query: 981 MVQE 984
M QE
Sbjct: 607 MTQE 610
Score = 48.5 bits (114), Expect = 3e-05
Identities = 39/152 (25%), Positives = 77/152 (50%), Gaps = 17/152 (11%)
Query: 870 QKQIEEQKE----EEKIREQQVKERRQREE--RRQSNLQEVLERERRELEKLYQERKMIE 923
+++I EQ+E +EKI EQ+ K R+Q E+ R++ + + E+ R + EK++++ + I
Sbjct: 529 EEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIR 588
Query: 924 ESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQE---QDQESADKSSKK 980
E + KI+++ E E E QE ++K E K+ +QE Q+QE + ++
Sbjct: 589 EQEE-KIREQEEKIREQEEMTQEQEEKMGEQEE------KMCEQEEKMQEQEEKMRRQEE 641
Query: 981 MVQEGSLVDTLQSSDKVESLTGFSHEELDDSW 1012
++E + +K+ E+ + W
Sbjct: 642 KIREQE-KKIREQEEKIREQEEMMQEQEEKMW 672
Score = 45.8 bits (107), Expect = 2e-04
Identities = 34/122 (27%), Positives = 66/122 (54%), Gaps = 5/122 (4%)
Query: 865 HPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSN-LQEVLERERRELEKLY-QERKMI 922
H ++ E+++E+E++ Q+ K R Q E RQ + E E+ R++ EK++ QE KM
Sbjct: 508 HEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMH 567
Query: 923 EESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMV 982
++ KI+ ++E E ++ QE +K E + + + + QEQ+++ ++ K
Sbjct: 568 DQEEKIREQEEKVWRQEEKIREQE--EKIREQEEKIRE-QEEMTQEQEEKMGEQEEKMCE 624
Query: 983 QE 984
QE
Sbjct: 625 QE 626
Score = 44.3 bits (103), Expect = 6e-04
Identities = 50/203 (24%), Positives = 99/203 (48%), Gaps = 15/203 (7%)
Query: 797 LYRRQTELQDKSEFSDVDKLAFKDN-EEFESSFESAGNM--PRQLEMGGLSPAGDMSHVD 853
L + +LQ+K + + +K + N +E + E A + +QL+ ++ V
Sbjct: 280 LKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVS 339
Query: 854 AAAAA-VPLSYQHPSVDQKQIEEQ-KEEEKIREQQVK----ERRQREERRQSNLQEVLER 907
A A V + ++Q+Q E+ ++EEKI+E + K E + RE+ + QE E+
Sbjct: 340 AKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQE--EK 397
Query: 908 ERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQ 967
RR+ E ++++ + + ++ +KE +M + EM E ++K E + + KI +Q
Sbjct: 398 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMM-WEKEEKIRELEEKMHEQEKIREQ 456
Query: 968 E---QDQESADKSSKKMVQEGSL 987
E Q++E + K+ QE +
Sbjct: 457 EEKRQEEEKIREQEKRQEQEAKM 479
Score = 44.3 bits (103), Expect = 6e-04
Identities = 46/186 (24%), Positives = 83/186 (44%), Gaps = 13/186 (6%)
Query: 792 EQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSH 851
+Q+ ++R++ ++Q+ E + + K E+ E E M RQ EM
Sbjct: 358 QQEEKMWRQEEKIQEWEE--KIQEQEEKIREQEEKIREQEEKMRRQEEMM-------WEK 408
Query: 852 VDAAAAAVPLSYQHPSVDQKQIEEQKE-EEKIREQQVKERRQREERRQSNLQEVLERERR 910
+ + ++ ++Q E E EEKIRE + K Q + R Q ++ E+ R
Sbjct: 409 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIRE 468
Query: 911 ELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQD 970
+ ++ QE KM + KI+ ++E E E +M QE K H + + + K +QE+
Sbjct: 469 QEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEK---IHEQEKIREEEKRQEQEEM 525
Query: 971 QESADK 976
+K
Sbjct: 526 WRQEEK 531
Score = 30.4 bits (67), Expect = 8.8
Identities = 22/88 (25%), Positives = 38/88 (43%)
Query: 894 EERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAH 953
++++ E L +ER L + +E LK K K E +E EI+
Sbjct: 248 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKE 307
Query: 954 SENPLEKYMKIIQQEQDQESADKSSKKM 981
+ LE+ ++ Q+Q Q AD K++
Sbjct: 308 LKRKLERAKLLLPQQQLQAEADHLGKEL 335
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin
(with transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 74.3 bits (181), Expect = 5e-13
Identities = 177/854 (20%), Positives = 351/854 (41%), Gaps = 127/854 (14%)
Query: 194 ESLEIKLNEYKREIEEQLRA--EMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEK 251
E L ++L + R+ + QL+ E Q+ + D +I K+K+ AK K LT N + +
Sbjct: 58 EQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAK----LTSL-NKYIE 112
Query: 252 ACQAKSEALVLREKSTLERIHKHQEIETK---EIYAQRQLLLKDMDLLRGREAELKQRVE 308
+A+ ++ E + E++ KH + T+ EI + L + +L+ +A+L Q
Sbjct: 113 EMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQA 172
Query: 309 AFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRL 368
+ E+ + + L+ +E+ I + + + + + + KD RL
Sbjct: 173 EQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRL 232
Query: 369 IEDER----KNKEKAVHLQEELIAINSKKEELNQS-VNRVKELELELESVKAQSLAITKQ 423
EDE + +Q++L + K EE +S V R + ++L ++ + A ++
Sbjct: 233 HEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDL----LQQELTAAEQR 288
Query: 424 NHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQ 483
N +L++++++M A++ L+ +E R E+ LL ++ EL V +
Sbjct: 289 NQILSQQLQQME-------------AEHNTLRNTVETEREESKILLEKM-----ELEVAE 330
Query: 484 KELRKAEKAIVVEH--EEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVAD 541
++L + H E+FE QA Q E+E ++ A +KA ++ T+ +
Sbjct: 331 RKLSFHNLQEEMHHLLEQFEQAGQA-----QAELE--SRYSALEQKHKAEMEEKTSHILS 383
Query: 542 LKLQLKQTQTALENEVYCNPK-------QSVIDRSVNGLINGNVVPCNGEISGDFLNN-P 593
L+ ++ Q+A + N K Q+V + + + EIS FLN P
Sbjct: 384 LQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEIS-QFLNRLP 442
Query: 594 FKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYH 653
+Q ++ T++P + EG+ ++ E +A+ + RV EL+ E L +
Sbjct: 443 LQQHETASQ------TSFPDVYNEGTQAVTE-ENIASLQKRVVELENEKGALLLSSIELE 495
Query: 654 RRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDV 713
+N K + LLEA +N T + DR VSE V +R+
Sbjct: 496 ELKAENE-------KLSSQITLLEA-QNRTGEA--------DREVSEISIVDIANKRSSS 539
Query: 714 VEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESE---MYLEGLGRSHIASPSPCPDRM 770
E S L S + + L + + E + L+ G+ + D+
Sbjct: 540 AEE---SGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQK 596
Query: 771 PLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFES 830
+ + I P+ K+ ++ T ++ L + E+ + +S
Sbjct: 597 EM----KQMEGEGIAPI------KMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQS 646
Query: 831 AGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKI---REQQV 887
+ L G+ D + +AVP Q + ++++ Q E ++ + Q++
Sbjct: 647 RTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEI 706
Query: 888 KERRQREERRQ-SNLQEVLE-----------------RERRELEKLYQERKMIEESLKIK 929
E+ E+ ++ SNL +++E ER +L +E M+ E L+ +
Sbjct: 707 YEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTE-LRAQ 765
Query: 930 IKK------ELEMENELEMSNQEIKD----KSAHSENPLEKYMKIIQQEQDQESADKSSK 979
+K+ E E + L+ +Q D + HS + +E K ++ E Q D
Sbjct: 766 VKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLS-IEAKSKDVKIEVLQNELDDVQL 824
Query: 980 KMVQEGSLVDTLQS 993
+ ++ +L+ +LQS
Sbjct: 825 QFSEQSTLIRSLQS 838
Score = 72.0 bits (175), Expect = 3e-12
Identities = 167/899 (18%), Positives = 360/899 (40%), Gaps = 98/899 (10%)
Query: 150 YHQAKE--SCNMETQTSSTFNRDSLAEKLQLIDDQFADAYP----------QRIKFESLE 197
+H+A+E N++ + N + L E+ + D + A+ ++K S+
Sbjct: 700 FHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMV 759
Query: 198 IKLNEYKREIEEQL-RAEMCQKLKFFKDT--------EIAKIKMEAKKKYEKELTMFQND 248
+L +++E L AE ++L + T +I + +EAK K + ++ + QN+
Sbjct: 760 TELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSK-DVKIEVLQNE 818
Query: 249 FEKACQAKSEALVL----------REKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRG 298
+ SE L +E LE + + I +K + L K++++ +
Sbjct: 819 LDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKM 878
Query: 299 REAELKQRVEAFELNQKLQEEKHKSITE-ALRRQEQNIKSFEETYDRKLKNELLKYQLEL 357
+ L+++ + L Q + EEK + +TE + E+ ++ EE + ++ + LK QL L
Sbjct: 879 DQLLLEKKRDVETLQQTI-EEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNL 937
Query: 358 KDDYIIRTNRLIEDERKNKEKAVHLQEELIAINS-KKEELNQSVNRVKELELELESVKAQ 416
+E++ + +E+ KEEL + +K+ E E K Q
Sbjct: 938 LSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKK-ENEQRKRKLQ 996
Query: 417 SLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPA 476
+ A+ + +L + + + LK+E + + ++ + ++EE + +
Sbjct: 997 A-ALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKC 1055
Query: 477 PELAVFQKELRKAEKAIVVEH------------EEFESCRQALHKQLQDEIEHSAQLKAQ 524
E+ ++ K+ +EK + ++H E+F++ + +++ LQD+ L+A+
Sbjct: 1056 QEIEIYLKQTI-SEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAE 1114
Query: 525 ILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGE 584
I +A ++ L T D A + + K++V+ ++ G+ E
Sbjct: 1115 ISENQAIIQKLITSNTD----------ASDGDSVALVKETVV---ISPPCTGSSEHWKPE 1161
Query: 585 ISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDL-EFVANTKARVKELQQEAE 643
+ L K++ L + + +T+ + + L E + K LQ++ +
Sbjct: 1162 LEEKILALE-KEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFD 1220
Query: 644 RLEKAFRSY--HRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSP--ERHIFGEDRVVS 699
K + R ++ + + K P + + SS+P E +F +
Sbjct: 1221 EQSKENENIGDQLRQLQIQVRESIDGKLPSTDQ-----QESCSSTPGLEEPLF----KAT 1271
Query: 700 EQPQVGTLEERNDVVEALTGSA-ASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRS 758
EQ + E N + + S AS L+GGTS ++ + +E E+ + S
Sbjct: 1272 EQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSST-TS 1330
Query: 759 HIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAF 818
+ S ++ + S+ VS E LQ K E S +
Sbjct: 1331 ELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEV------HAESLQQKLESSQLQIAGL 1384
Query: 819 KDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKE 878
+ E + + + + E +G +S +AA + Q +I EQ++
Sbjct: 1385 EHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKI----------QTEIIEQED 1434
Query: 879 EEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMEN 938
K Q++ + + + R LQ L +++ E++ +E + ++ ++ K++ L
Sbjct: 1435 LIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESR-AKQQIQRKLQAALISRK 1493
Query: 939 ELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKV 997
E N+ ++++ + + +E+ K + + Q SA K V G L + DK+
Sbjct: 1494 EALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVL-GRLALLQEERDKL 1551
Score = 69.3 bits (168), Expect = 2e-11
Identities = 175/882 (19%), Positives = 348/882 (39%), Gaps = 117/882 (13%)
Query: 159 METQTSSTFNRDSLAEKLQLIDD--QFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMC 216
+E + +ST ++ +E++ L D + K S + + ++ E+L++++
Sbjct: 635 VEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQIL 694
Query: 217 Q-KLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQ 275
+ +L F K EI + ++ K K L +F+K S A + + + + +
Sbjct: 695 ELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVK 754
Query: 276 EIE-TKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQN 334
E+ E+ AQ + L +M+L EAE ++R L+ + Q +TE +
Sbjct: 755 ELSMVTELRAQVKQL--EMNLA---EAERQRR-----LDYESQTAHDNLLTEQIHSLSIE 804
Query: 335 IKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIA-INSKK 393
KS ++ L+NEL QL+ + + R ++ + +NKE V E + I+SK
Sbjct: 805 AKS-KDVKIEVLQNELDDVQLQFSEQSTLI--RSLQSQLQNKESEVLEGAERVRHISSKV 861
Query: 394 EELNQSVNRVKELELELESVKAQSLAITKQNHM------LNEKVKEMSDYSLLKEEKLEL 447
EEL+Q+++ + ELE K L + K+ + + EK +++++ S EK+
Sbjct: 862 EELSQALS-----QKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQ 916
Query: 448 LAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQAL 507
L + K ++ E L LL+R + E E+ K ++E Q
Sbjct: 917 LNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQ---NYDEMSPAGQIS 973
Query: 508 HKQLQDEIE----HSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQ 563
++LQ E + + Q K ++ + K L +V+ L+ +L + + E+ + +
Sbjct: 974 KEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETE 1033
Query: 564 SVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAW---VEGSS 620
GE+ D N + ++ V ++ I T VE
Sbjct: 1034 ------------------RGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQH 1075
Query: 621 PDSDLE--------FVANTKARVKELQQEAERLE--KAFRSYHRRVIKNSAKSPLAAKSP 670
DLE F A K + LQ + +++ +A S ++ +I+ S A
Sbjct: 1076 IRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDG 1135
Query: 671 PSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTS 730
S+ L++ E + S + LEE+ +E +L+ +
Sbjct: 1136 DSVALVK----------ETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALT 1185
Query: 731 SRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSP 790
SR+ K++ E E +L R + +R+ +S+ +
Sbjct: 1186 SRKAI------LKKAQEKERHL----REELKQQKDDYNRLQEQFDEQSKEN--------- 1226
Query: 791 PEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESS--------FESAGNMPRQLEM-G 841
+ +G RQ ++Q + KL D +E SS F++ Q +
Sbjct: 1227 --ENIGDQLRQLQIQVRESIDG--KLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLES 1282
Query: 842 GLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNL 901
L P DA+A S K+IE +K E +++ ++ L
Sbjct: 1283 NLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQL 1342
Query: 902 QEVLERERRELEKL---YQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPL 958
QE + ++ E+E L E ++ ESL+ K++ ++L+++ E + + L
Sbjct: 1343 QEQINKQGLEIESLKTVSHEAEVHAESLQQKLE-----SSQLQIAGLEHLRELQPKLDEL 1397
Query: 959 EKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESL 1000
+K + +++ S S K+ + ++ D +++L
Sbjct: 1398 QKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKAL 1439
Score = 65.9 bits (159), Expect = 2e-10
Identities = 184/993 (18%), Positives = 406/993 (40%), Gaps = 123/993 (12%)
Query: 102 KEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMET 161
K K+ ++L+ ++ T + + S + + + L+E E+ ++ +T
Sbjct: 150 KHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQT 209
Query: 162 QTSSTFN-----RDSLAE-KLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQL---- 211
Q +D+ E +++L +D+ Q ++ KL +R++EE
Sbjct: 210 QAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLV 269
Query: 212 -RAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQA-KSEALVLREKSTLE 269
RA++ L+ ++ A+ + + + +++ N + + E+ +L EK LE
Sbjct: 270 GRAQVVDLLQ--QELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELE 327
Query: 270 RIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALR 329
+ ++ + + LL+ + +AEL+ R A E K + E+ S +L+
Sbjct: 328 VAER--KLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQ 385
Query: 330 R------------QEQNIKSFEETYDRKLKN----ELLKYQLELKDDYIIR-TNRLIEDE 372
+ ++QN K ++ ++ +++ + L+ QL+ K I + NRL +
Sbjct: 386 KTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQ 445
Query: 373 RKN------------------KEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVK 414
+ +E LQ+ ++ + ++K L S ++EL+ E E +
Sbjct: 446 HETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLS 505
Query: 415 AQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQ 474
+Q + QN E +E+S+ S++ +A + EES + L N +Q
Sbjct: 506 SQITLLEAQNRT-GEADREVSEISIVD------IANKR--SSSAEESGQDVLE--NTFSQ 554
Query: 475 PAPELAVFQKELRKAEKAIV----------VEHEEFESCRQALHKQLQDEIEHSAQLKAQ 524
EL+V E+++A++ I E + E Q KQ++ E ++K
Sbjct: 555 KHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVF 614
Query: 525 ILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSV-------NGLINGN 577
+ + + + L K+ Q + E++ + + S+ D V +G + +
Sbjct: 615 LEDTGQDFPLMPNEESSLPAVEKE-QASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLS 673
Query: 578 VVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKE 637
VP G+ D L E + ++++ + + + + D + ++N ++E
Sbjct: 674 AVPDIGQCHQDEL------ERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEE 727
Query: 638 LQQEAERLEKAFR--SYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGE- 694
++ A+ AF S R + + K L+ + + + N+ + +R + E
Sbjct: 728 FKKNADNNSSAFTALSEERDQLLSQVKE-LSMVTELRAQVKQLEMNLAEAERQRRLDYES 786
Query: 695 ----DRVVSEQPQVGTLEERN-DVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESE 749
D +++EQ ++E ++ DV + + ++ S + L ++ ESE
Sbjct: 787 QTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESE 846
Query: 750 MYLEGLGR-SHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPP-EQKVGLYRRQTELQDK 807
+ LEG R HI+S ++ S S+ L I + E+K + Q +++K
Sbjct: 847 V-LEGAERVRHISS------KVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEK 899
Query: 808 SE------FSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDA---AAAA 858
+ FS +K+ + E+F E + QL + + V+ ++
Sbjct: 900 DQQVTEISFSMTEKMVQLNEEKFSLGVEIK-TLKEQLNLLSRAEEAKKEQVEEDNEVSSG 958
Query: 859 VPLSYQHPS-VDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQ 917
+ +Y S Q EE + E + +++ ++R+++ + N +E+L+R R E+L
Sbjct: 959 LKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEEL-- 1016
Query: 918 ERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKS 977
+LK + KKE+ + +E K+ +SE + + I+ Q ++K
Sbjct: 1017 ------ANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKE 1070
Query: 978 SKKMVQEGSLVDTLQSSDKVESLTGFSHEELDD 1010
+ L + L + ++ ++L ++ L D
Sbjct: 1071 VELQHIRKDLEEKLAAEEQFQALVKQMNQTLQD 1103
Score = 64.7 bits (156), Expect = 4e-10
Identities = 188/1011 (18%), Positives = 389/1011 (38%), Gaps = 173/1011 (17%)
Query: 102 KEKVFTMQD--LLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNM 159
++K+ T D LL+ ++ + K + G ++ +K +KE+ +K + +
Sbjct: 1548 RDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEK-----LVKEIESLKSSKIAEST 1602
Query: 160 ETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKL 219
E Q L ++ +++ + + + + + + + + K+E+ +LR+ K
Sbjct: 1603 EWQEK----HKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKK 1658
Query: 220 KFFKDTEIAKIKME---------AKKKYEKELTMFQN------------DFEKACQAKSE 258
+ K + A+ +ME AK K +K L + + D K C
Sbjct: 1659 ETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLL 1718
Query: 259 ALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQE 318
+ K LER+ E +K+ Q L+ + D L +LK ++E Q E
Sbjct: 1719 SSNASMKEELERVKMEYETLSKKF----QSLMSEKDSLSEEVQDLKHQIEGNVSKQANLE 1774
Query: 319 --EKHKSITEALRRQEQNIKSFEETYDR----------------KLKNELLKYQLELKDD 360
EKH + T Q+I E D K N + D+
Sbjct: 1775 ATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDE 1834
Query: 361 YIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAI 420
N ++ + KE+ L+EE K +E +Q++ K L S K L
Sbjct: 1835 I----NNYLQQIDQLKERIAGLEEE----KQKNKEFSQTLENEKNTLLSQISTKDGELK- 1885
Query: 421 TKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNE-NLRLLNRLAQPAPEL 479
ML E+V +M+ LL ++ E L++ LK+ EE +++ RL+N+LA+ +
Sbjct: 1886 -----MLQEEVTKMN---LLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSI 1937
Query: 480 AVFQKELRKAE---KAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQIL---------- 526
+ +++ A+ + + E + + C L ++ Q ++ +++++I
Sbjct: 1938 GNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGA 1997
Query: 527 ----GYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCN 582
G K+ K L + + + ++KQ Q ++ + K S ++R+V L
Sbjct: 1998 QKEPGNKSHAKELQELLKEKQQEVKQLQ---KDCIRYQEKISALERTVKALEFVQTESQK 2054
Query: 583 G-EISGDFLNNPFK-QENVLARMVASRI----TNYPTAWVEGSSPDSDLEFVANTKARVK 636
EI+ + L + ++ A + + ++ T A V + E +N ++
Sbjct: 2055 DLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKS 2114
Query: 637 ELQQEAERLEKAFRSYHRRVIKN--SAKSPLAAKSPPSLHLLEAF--------------- 679
+++Q+ E LE+ + +K + + L A +HL E
Sbjct: 2115 QMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQ 2174
Query: 680 ---KNITSSSPERHIFGE---------DRVVSEQPQ--------VGTLEERNDVVEALTG 719
+N+ S+ + F + DRV+ E + + + EE + E
Sbjct: 2175 QLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCS 2234
Query: 720 SAASRLRGGT---SSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPT 776
+LR + +++ + L K+ ES+ E + + ++ L
Sbjct: 2235 VLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLE 2294
Query: 777 ESRHSLSIPPVSSPPEQKVGLYRRQTELQD-KSEFSDVDKLAFKDNEEFESSFESAGNMP 835
E+RH SS E L + ++EL+ K + +D+ + E E GN+
Sbjct: 2295 ETRHLYH----SSQNE----LAKLESELKSLKDQLTDL-------SNSLEKCKEQKGNLE 2339
Query: 836 -----RQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSV---DQKQIEEQKEEEKIREQQV 887
++ ++ + + D A+ S H + +QK I +E+ + +
Sbjct: 2340 GIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAI 2399
Query: 888 KERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEI 947
E RQ+ ++ L+ +L +E E L +E KK ++ N+L + + I
Sbjct: 2400 AELRQQHDKEIKELENLLSQEEEENIVLEEEN-----------KKAVDKTNQLMETLKTI 2448
Query: 948 KDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVE 998
K ++ + L+ ++K + Q+ + ++E L L+ ++
Sbjct: 2449 KKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQ 2499
Score = 64.7 bits (156), Expect = 4e-10
Identities = 186/896 (20%), Positives = 354/896 (39%), Gaps = 169/896 (18%)
Query: 178 LIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQK------LKFFKDTEIAKIK 231
+I Q AD + +E LE L + RE+ +L E+ K L K+ I
Sbjct: 2341 IIRQQEADIQNSKFSYEQLETDL-QASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAI 2399
Query: 232 MEAKKKYEKELTMFQNDFEKACQAKSEALVLREKS------------TLERIHKH---QE 276
E +++++KE+ +N Q + E +VL E++ TL+ I K Q+
Sbjct: 2400 AELRQQHDKEIKELENLLS---QEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQK 2456
Query: 277 IETKEIYAQRQLLLKDMDLLRGREAELKQR-----VEAFELNQKLQEEKHKSITEALRRQ 331
+ L D D + G +L++R +E +L Q+ E +K + E +R
Sbjct: 2457 AQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNK-LKEEIRGL 2515
Query: 332 EQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNR---LIEDE-RKNKE---KAVHLQE 384
++ + KL EL++Y+ +L I+ ++ L+E + ++NKE K L+E
Sbjct: 2516 RSHMDDLNSE-NAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEE 2574
Query: 385 ELIAINSKKEELNQSVNRVKE----LELELESVKAQSLAITKQNHMLNE----------- 429
+L E+L +S N ++E L E+ES+K +T+Q L E
Sbjct: 2575 KLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQL 2634
Query: 430 KVKE----------MSDYSLLKEEKLELLAQNK-----------LLKQQLEE-------S 461
KVKE S + E + EL+ K LK++L+
Sbjct: 2635 KVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIM 2694
Query: 462 RNENLRLLNRLAQPAPELAVFQKEL---RKAEKAIVVEHEEFESCRQALHKQLQDEIEHS 518
RNE R+A+ A +L +++L K K + + + F +L E
Sbjct: 2695 RNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEEL 2754
Query: 519 AQLKAQILGYKASVKSLTTQVADLKLQ--LKQTQTALENEVYCNPKQSVIDRSVNGL--I 574
+LK + Y AS+K L A LK Q L + + AL +E + S + S++ L +
Sbjct: 2755 DELKRK---YDASLKEL----AQLKEQGLLNRERDALLSETAFS-MNSTEENSLSHLEKL 2806
Query: 575 NGNVVPCNGEI--SGDFLNNPFKQENVLARMVASRITNYPTAWVE--------------G 618
N ++ + ++ L + + Q ++ +AS W E
Sbjct: 2807 NQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSA 2866
Query: 619 SSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHLLEA 678
+ P + V + K + LQ + +RL K ++ ++ ++ + + + P L+
Sbjct: 2867 AQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQE---ITELHPLKAQLQE 2923
Query: 679 FKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTP 738
+++ T + +++ E+ + L ++++ + ++ + RR+
Sbjct: 2924 YQDKTKAF---------QIMQEELRQENLSWQHELHQLRMEKSSWEIH----ERRMKEQY 2970
Query: 739 LPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLY 798
L + +L+ L R +S S PL + + S P S+ P+ L
Sbjct: 2971 LMAISDKDQQLSHLQNLIRELRSSSS---QTQPLKVQYQRQAS---PETSASPDGSQNLV 3024
Query: 799 RR----QTELQDKSEFSDVDKLAFKD-NEEFESSFESAGNMPRQLEMGGLSPAGDMSHVD 853
+T+L D + +L + N F E + QL S + H
Sbjct: 3025 YETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYG 3084
Query: 854 AAAAAVPLSYQHPSVDQKQIEE--------------QKEEEKIREQQVKERRQREERRQS 899
H +V +KQ++E +E+ + + E + ++ S
Sbjct: 3085 DL-------LNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFS 3137
Query: 900 NLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSE 955
Q+ L R+E+ +L RK++EE + + + EN L ++ ++I+ + HSE
Sbjct: 3138 EAQQQLCNTRQEVNEL---RKLLEE----ERDQRVAAENALSVAEEQIR-RLEHSE 3185
Score = 59.7 bits (143), Expect = 1e-08
Identities = 185/964 (19%), Positives = 379/964 (39%), Gaps = 127/964 (13%)
Query: 97 ESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKES 156
E AK+++ Q LQ I+ +L ++ + +G + K LA+ +
Sbjct: 1473 EESRAKQQI---QRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSA 1529
Query: 157 CNMETQTSS------TFNRDSLAEKLQ--LIDDQFADAYPQRIKFESLEIKLNEYKREIE 208
N E T RD L ++ L+++Q + + +K +LE L E K ++
Sbjct: 1530 QNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKL-ALE-GLTEDKEKLV 1587
Query: 209 EQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLR-EKST 267
+++ E + K + TE + E +K+YE L ++N +A + + +R EK
Sbjct: 1588 KEI--ESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQE 1645
Query: 268 LERIHKHQEIETKEIYAQRQLLLKDMDLLRGRE---AELKQR--VEAFELNQKLQEEKHK 322
L + E KE Q Q ++M+ ++ + A+ KQ+ +E E N +L+ E H
Sbjct: 1646 LYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHP 1705
Query: 323 -------------SITEALRRQEQNIKSFEETYDRKLKNEL------------LKYQLEL 357
S +++ + + +K ET +K ++ + LK+Q+E
Sbjct: 1706 AGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEG 1765
Query: 358 KDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQ-SVNRVKELELELESVKAQ 416
+ +E K+ + +E +I + EE + S++ + S K+
Sbjct: 1766 N----VSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSA 1821
Query: 417 SLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPA 476
+ A++K +E + LKE L + + K+ + NE LL++++
Sbjct: 1822 NPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKD 1881
Query: 477 PELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKS-L 535
EL + Q+E+ K L++Q+Q+E+ +LK K ++ L
Sbjct: 1882 GELKMLQEEVTK---------------MNLLNQQIQEELSRVTKLKETAEEEKDDLEERL 1926
Query: 536 TTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSV-NGLING---NVVPCNGEISGDFLN 591
Q+A+L + YC Q V D + N L+ N+ C E+ +
Sbjct: 1927 MNQLAELNGSIGN---------YC---QDVTDAQIKNELLESEMKNLKKCVSELEEE--- 1971
Query: 592 NPFKQENVLAR-MVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFR 650
KQ+ V + V S I ++G+ + K+ KELQ+ + ++ +
Sbjct: 1972 ---KQQLVKEKTKVESEIRKEYLEKIQGAQKE------PGNKSHAKELQELLKEKQQEVK 2022
Query: 651 SYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEER 710
+ I+ K ++ +L ++ T S + I E+ + + + E
Sbjct: 2023 QLQKDCIRYQEKISALERTVKALEFVQ-----TESQKDLEITKENLAQAVEHRKKAQAEL 2077
Query: 711 NDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRM 770
L + + R + +L L K S++S+M +
Sbjct: 2078 ASFKVLLDDTQSEAARVLADNLKLKK-ELQSNKESVKSQMKQKD---------------E 2121
Query: 771 PLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFES 830
L E + + E+ L R + L++ ++ K ++E + E+
Sbjct: 2122 DLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEE--TIGEIQVTLNKKDKEVQQLQEN 2179
Query: 831 AGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKER 890
+ QL S + S D + + + I+ ++EE +++E
Sbjct: 2180 LDSTVTQLAAFTKSMS---SLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVL 2236
Query: 891 RQREERRQSNLQEV-LERERRELEK-LYQERKMIEESLKIKIKKELEMEN-ELEMSNQEI 947
+ + + +++E+ + R E +K +++ + E L+ K+ L+ EN EL +E
Sbjct: 2237 KDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEET 2296
Query: 948 KDKSAHSENPLEKYMKIIQQEQDQ--ESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSH 1005
+ S+N L K ++ +DQ + ++ K Q+G+L ++ + + FS+
Sbjct: 2297 RHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSY 2356
Query: 1006 EELD 1009
E+L+
Sbjct: 2357 EQLE 2360
Score = 59.7 bits (143), Expect = 1e-08
Identities = 180/929 (19%), Positives = 345/929 (37%), Gaps = 121/929 (13%)
Query: 144 LKELAEYHQAKESCNMETQTSST------FNRDSLAEKLQLIDDQFADAYPQRIKFESLE 197
L A + E ME +T S +DSL+E++Q + Q ++ E+ E
Sbjct: 1718 LSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATE 1777
Query: 198 IKLNEYK----------REIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQN 247
N+ E EEQ M + + AK A K N
Sbjct: 1778 KHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINN 1837
Query: 248 DFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRV 307
++ Q K L E+ + Q +E ++ Q+ KD +L +E K +
Sbjct: 1838 YLQQIDQLKERIAGLEEEKQKNKEFS-QTLENEKNTLLSQISTKDGELKMLQEEVTKMNL 1896
Query: 308 EAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKL---KNELLKYQLELKDDYIIR 364
LNQ++QEE + +T+ E+ EE +L + Y ++ D I
Sbjct: 1897 ----LNQQIQEELSR-VTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQI-- 1949
Query: 365 TNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQN 424
N L+E E KN +K V + +EE Q V ++E E+ + + ++
Sbjct: 1950 KNELLESEMKNLKKCV---------SELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKE 2000
Query: 425 HMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQK 484
KE+ + K+++++ L ++ + Q+ + ++ L + + +
Sbjct: 2001 PGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK----DL 2056
Query: 485 ELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSA--------QLKAQILGYKASVKSLT 536
E+ K A VEH + A K L D+ + A +LK ++ K SVKS
Sbjct: 2057 EITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQM 2116
Query: 537 TQV-ADLKLQLKQTQTA-LENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPF 594
Q DL+ +L+Q + L+ + K + R ++ GEI LN
Sbjct: 2117 KQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRRE-----KVHLEETIGEIQVT-LNKKD 2170
Query: 595 KQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHR 654
K+ L + S +T SS D + V + E ++ + A +S
Sbjct: 2171 KEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRV------IDEAKKWERKFSDAIQSKEE 2224
Query: 655 RV-IKNSAKSPLAAK-SPPSLHLLEAFKNITSSSPERHIF---GEDRVVSEQPQVGTLEE 709
+ +K S L + S+H+ E NI+ ++ I+ + V +Q TL+
Sbjct: 2225 EIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQG 2284
Query: 710 RN-------DVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLES----EMYLEGLGRS 758
N + L S+ + L S + L SLE + LEG+ R
Sbjct: 2285 ENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQ 2344
Query: 759 HIASPSPCP--------DRMPLPSPTESRHS------LSIPPVSSPPEQKVGLYRRQTEL 804
A D T H I + S E+ + + +
Sbjct: 2345 QEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQ 2404
Query: 805 QDKSEFSDVDKLAFKDNEE---FESSFESAGNMPRQL-------EMGGLSPAGDMSHVDA 854
Q E +++ L ++ EE E + A + QL + + +
Sbjct: 2405 QHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVK 2464
Query: 855 AAAAVPLSYQHPSVDQKQIEEQ------KEEEKIREQQVKERRQREERR--QSNLQEVLE 906
+ +++ D +Q+EE+ ++++ I+E + + +EE R +S++ ++
Sbjct: 2465 SMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNS 2524
Query: 907 RERRELEKLYQERKMIEESLKIK-----------IKKELEMENELEMSNQEIKDKSAHSE 955
+ +L Q R+ + + + IK +++ E+EN+ +++K+ +E
Sbjct: 2525 ENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANE 2584
Query: 956 NPLEKYMKIIQQEQDQESADKSSKKMVQE 984
+ + + +++QD +S K + +
Sbjct: 2585 DLRRSFNALQEEKQDLSKEIESLKVSISQ 2613
Score = 52.8 bits (125), Expect = 2e-06
Identities = 99/474 (20%), Positives = 188/474 (39%), Gaps = 30/474 (6%)
Query: 100 LAKEKVFTMQDLLQLIKINP--TSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQA--KE 155
LA++ V Q LL + K N T+ + S S +N + L EL + A KE
Sbjct: 2708 LARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKE 2767
Query: 156 SCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEM 215
++ Q RD+L L + F+ + LE KLN+ +EQL
Sbjct: 2768 LAQLKEQGLLNRERDAL-----LSETAFSMNSTEENSLSHLE-KLNQQLLSKDEQLLHLS 2821
Query: 216 CQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAK---------SEALVLREKS 266
Q + + M + + L F K+ + K S A V K
Sbjct: 2822 SQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKK 2881
Query: 267 TLERIHKHQEIETKEI------YAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEK 320
+ + ++ KE+ Y Q + ++ L+ + E + + +AF++ Q+ ++
Sbjct: 2882 AMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQE 2941
Query: 321 HKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAV 380
+ S L + KS E ++R++K + L + KD + LI + R + +
Sbjct: 2942 NLSWQHELHQLRME-KSSWEIHERRMKEQYLM-AISDKDQQLSHLQNLIRELRSSSSQTQ 2999
Query: 381 HLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEM-SDYSL 439
L+ + E + S + + L E E ++ Q K+ H +++++ S++S
Sbjct: 3000 PLKVQYQ--RQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQ 3057
Query: 440 LKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEE 499
L EEK L Q Q L E++ LLN A ++ Q + A E+
Sbjct: 3058 LLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEK 3117
Query: 500 FESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTAL 553
R++ ++L++ + ++ + Q+ + V L + + + Q + AL
Sbjct: 3118 NGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENAL 3171
Score = 47.4 bits (111), Expect = 7e-05
Identities = 84/473 (17%), Positives = 198/473 (41%), Gaps = 51/473 (10%)
Query: 117 INPTSSLYKSLVSGSDKEN--QKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAE 174
++ T+ L ++L + KEN QK L F+K ++ ++ + Q + + E
Sbjct: 2435 VDKTNQLMETLKT-IKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILE 2493
Query: 175 KLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQ---------KLKFFKDT 225
K QLI + A+ + + L +++ E +L AE+ Q +K +
Sbjct: 2494 KDQLIQEAAAENNKLKEEIRGLRSHMDDLNSE-NAKLDAELIQYREDLNQVITIKDSQQK 2552
Query: 226 EIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEA-----LVLREKSTLERIHKHQEIETK 280
++ +++++ K+ E + + +++ +A + + EK L + + ++
Sbjct: 2553 QLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSIS 2612
Query: 281 EIYAQRQLLLKDMDL------LRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQN 334
++ Q L ++ L L+ +E E+ + F +QK E + + + +
Sbjct: 2613 QLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKK 2672
Query: 335 IKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKA---VHLQEELIAINS 391
+ E+ ++LK+ L D I N E + E A V ++++L+ +
Sbjct: 2673 VGEIEDKLKKELKH--------LHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTK 2724
Query: 392 KKEELN---QSVNR-VKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLEL 447
+ + L QS R + L+ + + + ++ +++ ++ + LL E+ L
Sbjct: 2725 ENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDAL 2784
Query: 448 LAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQAL 507
L++ EE+ +L LN+ +L ++L + + + +S +A+
Sbjct: 2785 LSETAFSMNSTEENSLSHLEKLNQ------QLLSKDEQLLHLSSQLEDSYNQVQSFSKAM 2838
Query: 508 HKQLQDEIEH----SAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENE 556
LQ+E +H + + G + S +T A+++ LK+ ++L+N+
Sbjct: 2839 -ASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQ-SLKKAMSSLQND 2889
Score = 46.2 bits (108), Expect = 2e-04
Identities = 133/679 (19%), Positives = 265/679 (39%), Gaps = 82/679 (12%)
Query: 367 RLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHM 426
+L E E + E + + + K EE+ Q ++ + LE+ES+K ++ + +
Sbjct: 1310 QLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLK----TVSHEAEV 1365
Query: 427 LNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKEL 486
E +++ + S L+ LE L ++L+ +E +L+++ + L+ E
Sbjct: 1366 HAESLQQKLESSQLQIAGLEHL-------RELQPKLDELQKLISKKEEDVSYLSGQLSEK 1418
Query: 487 RKAEKAIVVEHEEFESCRQALHKQLQDEI-EHSAQLKAQILGYKASVKSLTTQVADLKLQ 545
A I E E E +ALH QL+ + EH ++K Q+ +K ++ +
Sbjct: 1419 EAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIK-QLQVELCEMKQKPEEIGEESRA 1477
Query: 546 LKQTQTALENEVYCNPKQSVIDRSVN---GLINGNV---VPCNGEISGDFLNNPFKQENV 599
+Q Q L+ + + ++S+ L G + ++ +++ V
Sbjct: 1478 KQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV 1537
Query: 600 LARMVASR------ITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYH 653
L R+ + IT + +E S S E + K ++ L ++ E+L K S
Sbjct: 1538 LGRLALLQEERDKLITEMDRSLLENQSLSSSCE---SLKLALEGLTEDKEKLVKEIESLK 1594
Query: 654 RRVIKNSAKSPLAAKSPPSLH--LLEAFKNITSSS------------PERHIFGEDRVVS 699
I S + K + LL++++N+++ + ++ ++G+ R S
Sbjct: 1595 SSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLR--S 1652
Query: 700 EQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMY-------- 751
+ E++ E ++R S++ L + L +E++
Sbjct: 1653 TEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKE 1712
Query: 752 -LEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTE--LQDKS 808
+E L S+ AS +R+ + T S+ S+ ++V + Q E + ++
Sbjct: 1713 CMETLLSSN-ASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQA 1771
Query: 809 EFSDVDKLAFKDNEEFESSFESAGNMPRQLEMG-GLSPAGDMSHVDAAAAAVPLSYQHPS 867
+K + N E + G Q + P S A +A +S S
Sbjct: 1772 NLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSS 1831
Query: 868 VDQ-----KQIEEQK------EEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLY 916
D+ +QI++ K EEEK Q+ KE Q E ++ L + + EL+ L
Sbjct: 1832 HDEINNYLQQIDQLKERIAGLEEEK---QKNKEFSQTLENEKNTLLSQISTKDGELKMLQ 1888
Query: 917 QE-------RKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQ 969
+E + I+E L K + E E + + + ++ A + Y + + Q
Sbjct: 1889 EEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQ 1948
Query: 970 DQ----ESADKSSKKMVQE 984
+ ES K+ KK V E
Sbjct: 1949 IKNELLESEMKNLKKCVSE 1967
Score = 35.0 bits (79), Expect = 0.36
Identities = 85/443 (19%), Positives = 171/443 (38%), Gaps = 67/443 (15%)
Query: 118 NPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTF---------- 167
N S K++ S +N++ L + L++ + + K+ + TS
Sbjct: 2829 NQVQSFSKAMAS---LQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSS 2885
Query: 168 ---NRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEE-QLRAEMCQKLKFFK 223
+RD L ++L+ + Q+ + + L+ +L EY+ + + Q+ E ++
Sbjct: 2886 LQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSW 2945
Query: 224 DTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIY 283
E+ +++ME K +E + + A K + L + E + + ++
Sbjct: 2946 QHELHQLRME-KSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQ 3004
Query: 284 AQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYD 343
QRQ + G +Q L E TE LR Q + S +E +
Sbjct: 3005 YQRQASPETSASPDG--------------SQNLVYE-----TELLRTQLND--SLKEIHQ 3043
Query: 344 RKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRV 403
++L+ + L ++L+E++ ++ L + ++ ++ +N
Sbjct: 3044 KELRIQQLNSNF----------SQLLEEK---NTLSIQLCDTSQSLRENQQHYGDLLNHC 3090
Query: 404 KELELELESVKAQSLAITKQNHMLNEK--VKEMSDYSLLKEEKLELLAQNKLLKQQLEES 461
LE +++ ++A L I EK V SD L+E + +QQL +
Sbjct: 3091 AVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSF----SEAQQQLCNT 3146
Query: 462 RNENLRLLNRLAQPAPELAVFQKELRKAEKAI-VVEHEEFESCRQAL--------HKQLQ 512
R E L L + + + L AE+ I +EH E++S R + L
Sbjct: 3147 RQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQALLI 3206
Query: 513 DEIEHSAQLKAQILGYKASVKSL 535
D +S + +G+K ++SL
Sbjct: 3207 DLTSNSCRRTRSGVGWKRVLRSL 3229
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 73.2 bits (178), Expect = 1e-12
Identities = 194/907 (21%), Positives = 372/907 (41%), Gaps = 136/907 (14%)
Query: 144 LKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDD-QFADAYPQRIKFESLEIKLN- 201
++ L E HQ + S + + TF DS EKL L+ + Q + ++ E E LN
Sbjct: 426 VQSLKEQHQKEIS-----ELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNY 480
Query: 202 EYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALV 261
E REI E L+ E+ + KI E + +++ + +K A +E
Sbjct: 481 ESLREIMEILQTELGESA--------GKISQEFESMKQQQASDVHELQQKLRTAFTEKDA 532
Query: 262 LREKSTLERIHKHQE--IETKEIYAQRQLLLKDMDLLRGREA-ELKQRVEAF-ELNQK-- 315
L E T+ R+ E + +E+ + + +K++ G L QR EL K
Sbjct: 533 LLE--TVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKIN 590
Query: 316 -LQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERK 374
L EEK I + L+ + + +F + +R+ E L +L K + I+ N E E+K
Sbjct: 591 SLTEEKDDFINK-LKNSHEEMDNFHKKCERE---ERLILELGKKVEQTIQYNS--ELEQK 644
Query: 375 NKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEM 434
E L+E L + ++L + + ++K L + E + A+ ++ ++N+ L+ + K++
Sbjct: 645 VNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQL 704
Query: 435 SDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIV 494
S LE+ K E + ++ + + EK +
Sbjct: 705 S-------RDLEVFLSQK-------------------------EDVILKEHITQLEKKLQ 732
Query: 495 VEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLK-----LQLKQT 549
+ EE ++ L+K L++E +K Q+ G+ + S ++ ++ K LQ
Sbjct: 733 LMVEEQDN----LNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGE 788
Query: 550 QTALENEVYCN------PKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARM 603
A NE CN K +++ + L +VV C S L ++QE VL R
Sbjct: 789 SLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKS---LLRDYEQEKVLLRK 845
Query: 604 VASRITNYPTAWVEGSSPDSDLEFVANTKARVK-ELQQEAERLEKAFRSYHRRVIKNSAK 662
I + E + SDL + N + + E Q ++E+ ++ + I N K
Sbjct: 846 ELEEIQS------EKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNE-K 898
Query: 663 SPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVS---EQPQVGTLEERNDVVEALTG 719
K +L L K + E + + S + + +++E + +E L
Sbjct: 899 EKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEK 958
Query: 720 SAASRLRGGTSSRRLSSTPL--PKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTE 777
+ +++ L KAK+ L+S + + S D++
Sbjct: 959 ECKEK------EEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQL------- 1005
Query: 778 SRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQ 837
S S+ + E L E + +SE DV+K + FE E ++ RQ
Sbjct: 1006 ---SASMRDLIQGAESYKNLL---LEYEKQSEQLDVEK---ERANNFEHRIE---DLTRQ 1053
Query: 838 LEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQI----------EEQKEEEKIREQQV 887
L L S + A + + + + QI +++ E EK++++Q
Sbjct: 1054 LRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQK 1113
Query: 888 KERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEM---ENELEMSN 944
+ LQ L++E+++L+K QE +++++ + +E+ E ++ N
Sbjct: 1114 IKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELN 1173
Query: 945 QEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFS 1004
Q++ +K+ E+ LE+ +KI Q+Q QE+ + + + S+ + + K++ L +
Sbjct: 1174 QKLTNKNNKIED-LEQEIKI--QKQKQETLQEEITSL--QSSVQQYEEKNTKIKQLLVKT 1228
Query: 1005 HEELDDS 1011
+EL DS
Sbjct: 1229 KKELADS 1235
Score = 70.9 bits (172), Expect = 6e-12
Identities = 93/442 (21%), Positives = 202/442 (45%), Gaps = 39/442 (8%)
Query: 144 LKELAE-YHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNE 202
+KEL E ++ C + + + ++ K +L D + + + ESL + ++
Sbjct: 946 VKELEEKIENLEKECKEKEEKINKIKLVAVKAKKEL-DSSRKETQTVKEELESLRSEKDQ 1004
Query: 203 YKREIEEQLRAEMCQK---LKFFKDTEIAKIKMEAKKKYE---KELTMFQNDFEKACQ-- 254
+ + ++ K L++ K +E ++ E +E ++LT + C+
Sbjct: 1005 LSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETI 1064
Query: 255 -AKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLR-GREAELKQRV----E 308
+ +E L+ R + TL+ K E++ E+ + ++ K+++ + +E ++K+ E
Sbjct: 1065 NSDNEDLLARIE-TLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNE 1123
Query: 309 AFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKD--DYIIRTN 366
EL +LQ+EK K + + ++ E K ++T + E+ Y+ +K+ + N
Sbjct: 1124 LEELQVQLQKEK-KQLQKTMQELELVKKDAQQT--TLMNMEIADYERLMKELNQKLTNKN 1180
Query: 367 RLIEDERKN----KEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITK 422
IED + K+K LQEE+ ++ S ++ + ++K+L ++ + A S
Sbjct: 1181 NKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAET 1240
Query: 423 QNHMLNEKVK-----EMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAP 477
+ +L +K + K + E+ ++ + + L+ S ++ R L+ Q
Sbjct: 1241 DHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQ--- 1297
Query: 478 ELAVFQKELR--KAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSL 535
+ Q+E R KAE+A V EFES + +H L+ + ++ + +A+ G K + L
Sbjct: 1298 RVTALQEECRAAKAEQATVTS--EFESYKVRVHNVLKQQ-KNKSMSQAETEGAKQEREHL 1354
Query: 536 TTQVADLKLQLKQTQTALENEV 557
+ LK++L+ +Q L+ V
Sbjct: 1355 EMLIDQLKIKLQDSQNNLQINV 1376
Score = 70.1 bits (170), Expect = 1e-11
Identities = 114/582 (19%), Positives = 229/582 (39%), Gaps = 77/582 (13%)
Query: 18 ELRKKLYQTFKDRGILDTLKTQLRNQLIHELMHPV--------LSGELQPRSISVEGSSL 69
+L KKL +++ D L L N+ + +L + E+ S + ++
Sbjct: 726 QLEKKLQLMVEEQ---DNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNV 782
Query: 70 LIGASNSLVADHLQRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVS 129
L SL + ++C + E L EK +++ SL +
Sbjct: 783 LQAVGESLAKINEEKCNLAFQRD----EKVLELEKEIKCLQEESVVQCEELKSLLR---- 834
Query: 130 GSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQ 189
D E +K L L+E+ +A +S +E + ++ R L +++
Sbjct: 835 --DYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKS 892
Query: 190 RIKFESLEIKLNEYK--------REIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKE 241
I E + + E++ +E+ ++ + K K + + + K+ E++
Sbjct: 893 EIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEK 952
Query: 242 LTMFQNDFEKACQAKSEAL------VLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDL 295
+ + EK C+ K E + ++ K L+ K ET+ + + + L + D
Sbjct: 953 I----ENLEKECKEKEEKINKIKLVAVKAKKELDSSRK----ETQTVKEELESLRSEKDQ 1004
Query: 296 LRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQL 355
L +L Q E+++ N L+ EK + + + N + E R+L+N L+ +
Sbjct: 1005 LSASMRDLIQGAESYK-NLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCET 1063
Query: 356 ELKD--DYIIRTNRL-----------IEDERKNKEKAVHLQEELIAINSKKEELNQSVNR 402
D D + R L +E +R L+ E + K +E +VN
Sbjct: 1064 INSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNE 1123
Query: 403 VKELELELESVKAQSLAITKQNHMLNEKVK-------EMSDYSLLKEE----------KL 445
++EL+++L+ K Q ++ ++ + + E++DY L +E K+
Sbjct: 1124 LEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKI 1183
Query: 446 ELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQ 505
E L Q +++Q +E+ E + L Q E K+L K + + ++ E+
Sbjct: 1184 EDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHL 1243
Query: 506 ALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLK 547
L L+ E+E S Q Q+ YK + +T++ + LK
Sbjct: 1244 ILQASLKGELEASQQ---QVEVYKIQLAEITSEKHKIHEHLK 1282
Score = 53.9 bits (128), Expect = 7e-07
Identities = 166/896 (18%), Positives = 361/896 (40%), Gaps = 158/896 (17%)
Query: 189 QRIKFES-LEIKLNEYKREIEEQLRAE----------MCQKLKFFKDTEIAKIKMEA--- 234
Q I++ S LE K+NE +EE L+ + M Q +D E+ ++++
Sbjct: 633 QTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYE 692
Query: 235 --------KKKYEKELTMFQNDFEKACQA-------KSEALVLREKSTLERIHKHQEIET 279
KK+ ++L +F + E K L++ E+ L ++ ++++++
Sbjct: 693 ENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQK 752
Query: 280 KEIYAQRQLLLKDMDLLRGREAELKQRVEAFE-LNQKLQEEKHKSITEALRRQEQNIKSF 338
+ Q LK+M ++E K V + + + L + + A +R E+ +
Sbjct: 753 LFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVL--- 809
Query: 339 EETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQ 398
EL K L+++ +++ L R +++ V L++EL I S+KE L
Sbjct: 810 ----------ELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQS 859
Query: 399 SVNRVK----ELELELESVKAQSLAITK---QNHMLNEK----VKEMSDYSLLKEEK--L 445
+ +K + LE +++ Q +++ ++ + NEK +KE + L E+K
Sbjct: 860 DLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELR 919
Query: 446 ELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAI-------VVEHE 498
+ A+ LLK L +S + L+ + + ++ +KE ++ E+ I V +
Sbjct: 920 DRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKK 979
Query: 499 EFESCR---QALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALEN 555
E +S R Q + ++L+ QL A + +S + + + Q +Q +E
Sbjct: 980 ELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLD--VEK 1037
Query: 556 EVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVA----SRITNY 611
E N + + D + + + + C I+ D E++LAR+ +++
Sbjct: 1038 ERANNFEHRIED--LTRQLRNSTLQCE-TINSD-------NEDLLARIETLQSNAKLLEV 1087
Query: 612 PTAWVEGSSPDSDLEFVANTKARVKELQQEA------ERLEKAFRSYHRRVIKNSAKSPL 665
V+ + D E A + +++++ A E L+ + +++ K + L
Sbjct: 1088 QILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELEL 1147
Query: 666 AAKSPPSLHLL------------EAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDV 713
K L+ E + +T+ + + ++ + +Q Q EE
Sbjct: 1148 VKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEE---- 1203
Query: 714 VEALTGSAASRLRGGTSSRRL---SSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPD-- 768
+ +L S T ++L + L +K++ + L+ + + + +
Sbjct: 1204 ITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVY 1263
Query: 769 RMPLPSPTESRHSLSIPPVSSPPEQKVGL---YRRQTELQDKSEFSDVDKLAFKDNEEFE 825
++ L T +H + +S + + L +R T LQ++ + ++ EFE
Sbjct: 1264 KIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATV--TSEFE 1321
Query: 826 SSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQ 885
S N+ +Q ++ S+ Q + E K+E + E
Sbjct: 1322 SYKVRVHNVLKQ-------------------------QKNKSMSQAETEGAKQEREHLEM 1356
Query: 886 QVKERRQREERRQSNLQ------EVLERERRELEKLYQERKMIEESLKIKIKKELEMENE 939
+ + + + + Q+NLQ + L+ E L L + KM++E+ + KE E+ +
Sbjct: 1357 LIDQLKIKLQDSQNNLQINVSELQTLQSEHDTL--LERHNKMLQET----VSKEAELREK 1410
Query: 940 L-EMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQE--GSLVDTLQ 992
L + ++ + KS H++ ++ Q + ++ + + +QE V+TLQ
Sbjct: 1411 LCSIQSENMMMKSEHTQT----VSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQ 1462
Score = 52.0 bits (123), Expect = 3e-06
Identities = 154/764 (20%), Positives = 303/764 (39%), Gaps = 109/764 (14%)
Query: 256 KSEALVLREKSTLERIHKH-QEIETKEIYAQR----QLLLKDMDLLRGREAELKQRVEAF 310
K L+ + KS + K +E+ +K + + L + +D L +AE +Q+ +
Sbjct: 36 KQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSL 95
Query: 311 EL-NQKLQEEKHKSIT---EALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTN 366
+ N K+++E S+T +A + EQ+ ++ + + LKNEL+ + + +D
Sbjct: 96 KKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIEN-LKNELMAVRSKYSEDKA---- 150
Query: 367 RLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVK----AQSLAITK 422
+ +K E+A++ Q EL + + + N S + VK+L+ E+E ++ Q L + K
Sbjct: 151 ----NLQKQLEEAMNTQLEL---SEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQK 203
Query: 423 QNHMLNEKVKE----------------MSDYSLLKEEKLELLA----QNKLLKQQLEESR 462
Q ++ KE + + L+EE L+L A + K L Q+E S
Sbjct: 204 QLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASA 263
Query: 463 NENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHE-EFESCRQALHKQLQDEIEHSAQL 521
E+ +N+L + L K+ +EK I ++E E E+ R+A QD
Sbjct: 264 KEHEAEINKLNELKENLV---KQCEASEKNIQKKYECELENLRKATSNANQDN------- 313
Query: 522 KAQILGYKASVKSLTTQVADLKLQ-LKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVP 580
QI + QV + K++ L+ T LE++ S++ V + N +
Sbjct: 314 --QICSILLQENTFVEQVVNEKVKHLEDTLKELESQ------HSILKDEVTYM---NNLK 362
Query: 581 CNGEISGDFLNNPFKQE------NVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKAR 634
E+ + + F E + ++A ++ + +F +
Sbjct: 363 LKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQH 422
Query: 635 VKELQQEAERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGE 694
+E+Q E+ +K + + +S K L L E +N+ E + E
Sbjct: 423 NREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQ-GLKEQCENLQQEKQEAILNYE 481
Query: 695 D-RVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLE 753
R + E Q E + + + ++ T + LE+ L+
Sbjct: 482 SLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQ 541
Query: 754 GLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTEL-QDKSEFSD 812
G ++ P+ + ++ + + +S L + L ++K +F +
Sbjct: 542 GENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFIN 601
Query: 813 VDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPS-VDQK 871
K + ++ + F E + LE+G V + Q+ S ++QK
Sbjct: 602 KLKNSHEEMDNFHKKCEREERL--ILELG---------------KKVEQTIQYNSELEQK 644
Query: 872 QIE-----EQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESL 926
E E+ +EK + Q E+ + + S +EVL E++ LY+E +
Sbjct: 645 VNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLS---AEVKSLYEENNKLSSE- 700
Query: 927 KIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQD 970
KK+L + E+ +S +E H LEK ++++ +EQD
Sbjct: 701 ----KKQLSRDLEVFLSQKEDVILKEHI-TQLEKKLQLMVEEQD 739
Score = 47.4 bits (111), Expect = 7e-05
Identities = 86/442 (19%), Positives = 182/442 (41%), Gaps = 58/442 (13%)
Query: 108 MQDLLQLIKINPT---------SSLYKSLVSGSDKENQ-KGFLMHFLKELAEYHQAKESC 157
++DL Q IKI +SL S+ +K + K L+ KELA+ QA E+
Sbjct: 1183 IEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQA-ETD 1241
Query: 158 NMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKF-ESLEIKLNEYKREI--------- 207
++ Q S ++ +++++ Q A+ ++ K E L+ +++R +
Sbjct: 1242 HLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTA 1301
Query: 208 -EEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKS--EALVLRE 264
+E+ RA ++ + E K+++ K +K +M Q + E A Q + E L+ +
Sbjct: 1302 LQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQL 1361
Query: 265 KSTLERIHKHQEIETKEIYAQRQ----LLLKDMDLLR---GREAELKQRVEAFELNQKLQ 317
K L+ + +I E+ + LL + +L+ +EAEL++++ + + +
Sbjct: 1362 KIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMM 1421
Query: 318 EEKHKSITEALRRQEQNIKSFEETYDRKLKN------ELLKYQL--------ELKDDYII 363
+ +H L Q + +++ R L+ E L+ QL +LK++
Sbjct: 1422 KSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTT 1481
Query: 364 RTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQ 423
R+ + KN + + L+ +++ E + + + ESV + S
Sbjct: 1482 RSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETT-----DTESVSSASTYTQSL 1536
Query: 424 NHMLNEKVKEMS----DYSLLKEEKLELLAQNKL----LKQQLEESRNENLRLLNRLAQP 475
+LN ++ KEE ++ L+ L L E+ N L+ ++
Sbjct: 1537 EQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLL 1596
Query: 476 APELAVFQKELRKAEKAIVVEH 497
E+ ++ + + A +E+
Sbjct: 1597 KSEIRRLERNQEREKSAANLEY 1618
Score = 44.3 bits (103), Expect = 6e-04
Identities = 172/826 (20%), Positives = 325/826 (39%), Gaps = 124/826 (15%)
Query: 199 KLNEYKREIEEQL------RAEMCQKLKFFKDTE--IAKIKMEAKK---KYEKELTMFQN 247
K +E K +++QL + E+ ++LKF ++E + K++ E +K +E+++ Q
Sbjct: 144 KYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQK 203
Query: 248 DFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRV 307
+ K E V + ++ +E +H + K I + ++ LL+ + + EL ++
Sbjct: 204 QLDATTDEKKET-VTQLQNIIEANSQHYQ---KNINSLQEELLQLKAIHQEEVKELMCQI 259
Query: 308 EAFELNQKLQEEKHKSITEALRRQ-EQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTN 366
EA + + K + E L +Q E + K+ ++ Y+ +L+N L K D
Sbjct: 260 EASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELEN-LRKATSNANQD------ 312
Query: 367 RLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHM 426
N+ ++ LQE E++ + +KELE + S+ + +M
Sbjct: 313 --------NQICSILLQENTFVEQVVNEKVKHLEDTLKELESQ------HSILKDEVTYM 358
Query: 427 LNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKEL 486
N K+K D +K+E ++ LE NE LL + + + EL
Sbjct: 359 NNLKLKLEMDAQHIKDEFFH-------EREDLEFKINE---LLLAKEEQGCVIEKLKSEL 408
Query: 487 RKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVK-SLTTQVADLKLQ 545
K E+ Q+L +Q Q EI ++L L K +L ++ LK Q
Sbjct: 409 AGLNKQFCYTVEQHNREVQSLKEQHQKEI---SELNETFLSDSEKEKLTLMFEIQGLKEQ 465
Query: 546 LKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVA 605
+ Q + E N + R + ++ + G+IS +F KQ+ A V
Sbjct: 466 CENLQQE-KQEAILNYESL---REIMEILQTELGESAGKISQEF--ESMKQQQ--ASDVH 517
Query: 606 SRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKSPL 665
TA+ E D+ LE V + ++L + E + + + KN L
Sbjct: 518 ELQQKLRTAFTE---KDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVY--L 572
Query: 666 AAKSPPSLHLLEAFKNITSSSPERHIF-------------------GEDRVVSE-----Q 701
+ S L E I S + E+ F E+R++ E +
Sbjct: 573 LSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVE 632
Query: 702 PQVGTLEERNDVVEALTGSAASRLR-GGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHI 760
+ E V LTG L+ + ++L + S + E+ + +
Sbjct: 633 QTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYE 692
Query: 761 ASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDK-----SEFSDVDK 815
+ ++ L E V ++ V L T+L+ K E +++K
Sbjct: 693 ENNKLSSEKKQLSRDLE---------VFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNK 743
Query: 816 LAFKDNEEFESSFESAGNMPRQLEMGG-LSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIE 874
L +NE+ + F EMG +S + V AV S + ++ +
Sbjct: 744 LL--ENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLA 801
Query: 875 EQKEEEKIR-EQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKE 933
Q++E+ + E+++K LQE + EL+ L ++ E K+ ++KE
Sbjct: 802 FQRDEKVLELEKEIK-----------CLQEESVVQCEELKSLLRD----YEQEKVLLRKE 846
Query: 934 L-EMENELEMSNQEIKD-KSAHSENPLEKYMKIIQQEQDQESADKS 977
L E+++E E ++ + K+A+ + LE +IQ E+ ++ KS
Sbjct: 847 LEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKS 892
Score = 41.2 bits (95), Expect = 0.005
Identities = 42/178 (23%), Positives = 83/178 (46%), Gaps = 8/178 (4%)
Query: 797 LYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAA 856
L + +TE Q S + K K +E E S G+ ++LE ++ ++ ++
Sbjct: 83 LEKAETEQQCLS----LKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNEL 138
Query: 857 AAVPLSYQHPSVD-QKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERREL-EK 914
AV Y + QKQ+EE + +Q+K + E+ LQE +E+ R E+
Sbjct: 139 MAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSED-NVKKLQEEIEKIRPGFEEQ 197
Query: 915 LYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQE 972
+ +K ++ + K + +++N +E ++Q + K+ +S +K I QE+ +E
Sbjct: 198 ILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQ-KNINSLQEELLQLKAIHQEEVKE 254
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 73.2 bits (178), Expect = 1e-12
Identities = 91/443 (20%), Positives = 184/443 (41%), Gaps = 56/443 (12%)
Query: 143 FLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNE 202
+ +EL E + E T T N+ AE L+L D +L K +
Sbjct: 1140 YARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHAD 1199
Query: 203 YKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVL 262
E+ EQ+ K K K+ K++++ + ++ + + EK C+ + L
Sbjct: 1200 SVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSE 1259
Query: 263 REKSTLERIHKHQEIETKEIYAQRQL--LLKDMDLLRGREAELKQRVEAF-----ELNQK 315
E E+ T++ Q + L + ++ ++L + +AF EL ++
Sbjct: 1260 ARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQ 1319
Query: 316 LQEEKH--KSITEALRRQEQNIKSFEETYDR-------------KLKNELLKYQLELKDD 360
L+EE ++ AL+ + E Y+ K +E+ +++ + + D
Sbjct: 1320 LEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETD 1379
Query: 361 YIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNR----VKELELELESVKAQ 416
I RT L E ++K ++ +E++ A+N+K L ++ R V++L +++E +
Sbjct: 1380 AIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSL 1439
Query: 417 SLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRN---ENLRLLNRLA 473
+ A+ K+ ++ +L E K + L+ L+ESR+ E +L N
Sbjct: 1440 AAALDKKQRNFDK---------VLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYE 1490
Query: 474 QPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVK 533
+ +L ++E + E+ I E+ + +H E+E S K
Sbjct: 1491 EALDQLETVKRENKNLEQEIADLTEQIAENGKTIH-----ELEKSR-------------K 1532
Query: 534 SLTTQVADLKLQLKQTQTALENE 556
+ + AD++L L++ + ALE+E
Sbjct: 1533 QIELEKADIQLALEEAEAALEHE 1555
Score = 68.9 bits (167), Expect = 2e-11
Identities = 176/866 (20%), Positives = 327/866 (37%), Gaps = 147/866 (16%)
Query: 200 LNEYKREIEEQ---LRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAK 256
LN+ K ++E+Q L + + Q+ K D E K K+E K +E + D E Q
Sbjct: 1021 LNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESIL---DLENDKQQL 1077
Query: 257 SEALVLREKSTLERIHKHQEIETKEIYA-QRQLLLKDMDLLRGREAELKQRVEAFELNQK 315
E L +K E ++E ++ Q Q +K+ L+ R EL++ +EA E +
Sbjct: 1078 DERL---KKKDFEYCQLQSKVEDEQTLGLQFQKKIKE---LQARIEELEEEIEA-ERATR 1130
Query: 316 LQEEKHKS-----ITEALRRQEQ--NIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRL 368
+ EK +S + E R E+ + S + ++K + E LK + +L++ + +
Sbjct: 1131 AKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMV 1190
Query: 369 IEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVK----ELELELESVKAQSLAITKQN 424
+K+ + L E++ + K++L + + K +L +ESV + K
Sbjct: 1191 AALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKIC 1250
Query: 425 HMLNEKVKE--------MSDYSLLKEEKLELLAQNKLLKQQLEESRN---ENLRLLNRLA 473
L +++ E S L +K L + L +QLEE + + R
Sbjct: 1251 RTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFT 1310
Query: 474 QPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQI-------- 525
Q EL +E KA+ A+ + L +Q ++E E A+L+ +
Sbjct: 1311 QQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA 1370
Query: 526 ---LGYKASVKSLTTQVADLKLQLKQTQTALENEVYC-NPKQSVIDRSVNGLINGNVVPC 581
Y+ T ++ + K +L Q E +V N K + ++++ L
Sbjct: 1371 QWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRL-------- 1422
Query: 582 NGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQE 641
GE+ ++ ++ N LA + + N+ + +A K + +E Q E
Sbjct: 1423 QGEVEDLMVD--VERANSLAAALDKKQRNFD-------------KVLAEWKTKCEESQAE 1467
Query: 642 AERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQ 701
E K RS + K L +L LE K + + +++
Sbjct: 1468 LEASLKESRSLSTELFK------LKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENG 1521
Query: 702 PQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIA 761
+ LE+ +E L +A+ +LE E
Sbjct: 1522 KTIHELEKSRKQIELEKADI--------------QLALEEAEAALEHE------------ 1555
Query: 762 SPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDN 821
R L + V S ++K+ + E ++ V+ + +
Sbjct: 1556 ------------EAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALD 1603
Query: 822 EEFESSFESAGNMPRQLEMGGLSPAG-DMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEE 880
E S E+ + +++E G L+ +SH + AA + K + ++
Sbjct: 1604 AEVRSRNEAI-RLKKKME-GDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDA 1661
Query: 881 KIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESL-------------- 926
++ +KE+ ERR + LQ +E R LE+ + RK+ E+ L
Sbjct: 1662 LRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQN 1721
Query: 927 --KIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKII----------QQEQDQESA 974
I KK+L E +L E++D S + N EK K I ++EQD +
Sbjct: 1722 TSLIHTKKKL--ETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1779
Query: 975 DKSSKKMVQEGSLVDTLQSSDKVESL 1000
+ KK +++ ++ D D+ E L
Sbjct: 1780 LERMKKNLEQ-TVKDLQHRLDEAEQL 1804
Score = 61.2 bits (147), Expect = 5e-09
Identities = 170/886 (19%), Positives = 347/886 (39%), Gaps = 149/886 (16%)
Query: 171 SLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEM---------CQKL-- 219
++ E+ Q D+ A + +R + E + L + K +++ Q++AE C +L
Sbjct: 852 TMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIK 911
Query: 220 -KFFKDTEIAKI--KMEAKKKYEKELTMFQNDFEKACQAKSE---------ALVLREKST 267
KF + +I ++ + E +++ ELT + E C + A V +EK
Sbjct: 912 AKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA 971
Query: 268 LERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEA 327
E K+ T+E+ + + K L R ++A + +A + + + +E+K S+ +
Sbjct: 972 TENKVKNL---TEELSGLDETIAK---LTREKKALQEAHQQALD-DLQAEEDKVNSLNKT 1024
Query: 328 LRRQEQNIKSFEETYD--RKLKNELLKYQLELKDDYIIRTNRLIE--------DERKNKE 377
+ EQ ++ E + + +KL+ +L + + +L+ D + +++ DER K+
Sbjct: 1025 KSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKK 1084
Query: 378 KAVHLQ-------EELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEK 430
+ Q E+ + + +K+ + + R++ELE E+E+ +A KQ
Sbjct: 1085 DFEYCQLQSKVEDEQTLGLQFQKK-IKELQARIEELEEEIEAERATRAKTEKQR------ 1137
Query: 431 VKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAE 490
SDY+ EE L ++LEE+ + + E +++L +A
Sbjct: 1138 ----SDYARELEE----------LSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEA- 1182
Query: 491 KAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQ 550
++HE + AL K+ D + A+L QI + + L + ++ KL++
Sbjct: 1183 ---TLQHEAMVA---ALRKKHADSV---AELGEQIDNLQRVKQKLEKEKSEFKLEIDDLS 1233
Query: 551 TALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITN 610
+++E+ I R++ D L+ + + R ++ T
Sbjct: 1234 SSMESVSKSKANLEKICRTLE----------------DQLSEARGKNEEIQRSLSELTTQ 1277
Query: 611 YPTAWVEGSSPDSDLE----FVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKSPLA 666
E LE V+ + Q+ E L++ +N AK+ LA
Sbjct: 1278 KSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEE------ENKAKNALA 1331
Query: 667 AKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLR 726
H L++ RH R E+ Q G E + + +A + A R +
Sbjct: 1332 -------HALQS---------SRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTK 1375
Query: 727 GGTS----SRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRM-----PLPSPTE 777
T + L A+R +SE +E + + AS R+ L E
Sbjct: 1376 YETDAIQRTEELEEAKKKLAQRLQDSEEQVEAV-NAKCASLEKTKQRLQGEVEDLMVDVE 1434
Query: 778 SRHSLSIPPVSSP-------PEQKVGLYRRQTELQ-DKSEFSDVDKLAFKDNEEFESSFE 829
+SL+ E K Q EL+ E + FK +E + +
Sbjct: 1435 RANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALD 1494
Query: 830 SAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKE 889
+ R+ + +++ + A + +KQIE +K + ++ ++ +
Sbjct: 1495 QLETVKRE----NKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEA 1550
Query: 890 RRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELE-----MENELEMSN 944
+ EE + +Q L + + E+++ E+ E LK ++ +E ++ E+ N
Sbjct: 1551 ALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRN 1610
Query: 945 QEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDT 990
+ I+ K E L + ++I ++++A+ +G L DT
Sbjct: 1611 EAIRLKK-KMEGDLNE-IEIQLSHANRQAAETLKHLRSVQGQLKDT 1654
Score = 56.6 bits (135), Expect = 1e-07
Identities = 81/397 (20%), Positives = 163/397 (41%), Gaps = 90/397 (22%)
Query: 189 QRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQND 248
+ K ++++L + K EI+ ++ KD EI ++K + Y++ + Q+
Sbjct: 1555 EEAKILRIQLELTQVKSEIDRKIAE---------KDEEIEQLK----RNYQRTVETMQSA 1601
Query: 249 FEKACQAKSEALVLREK--STLERIH------KHQEIETKEIYAQRQLLLKDM-----DL 295
+ ++++EA+ L++K L I Q ET + Q LKD D
Sbjct: 1602 LDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDA 1661
Query: 296 LRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETY------------- 342
LRG+E +LK+++ E L + + + + L + E+ K E+
Sbjct: 1662 LRGQE-DLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQ 1720
Query: 343 -------DRKLKNELLKYQLELKD-------------DYIIRTNRLIEDERKNKEKAVHL 382
+KL+ +L++ Q E++D I + E+ +K ++ + HL
Sbjct: 1721 NTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1780
Query: 383 QE-------------------ELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQ 423
+ E +A+ K+++ + R++ELE ELE + ++ K
Sbjct: 1781 ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKG 1840
Query: 424 NHMLNEKVKEMSDYS------LLKEEKL--ELLAQNKLLKQQLEESRNENLRLLNRLAQP 475
+VKE++ S +L+ + L +L + K K+Q EE+ + L + +
Sbjct: 1841 LRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKA 1900
Query: 476 APELAVFQKELRKAEKAI---VVEHEEFESCRQALHK 509
EL ++ AE + + +F S R +H+
Sbjct: 1901 QHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHE 1937
Score = 39.7 bits (91), Expect = 0.014
Identities = 25/127 (19%), Positives = 67/127 (52%), Gaps = 10/127 (7%)
Query: 876 QKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELE 935
Q EE+K+ + + + + E++ +L+ LE+E++ L + ++ +E LK+ + L+
Sbjct: 1012 QAEEDKVNS--LNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILD 1069
Query: 936 MENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQE-GSLVDTLQSS 994
+EN+ + ++ +K K +Y ++ + +D+++ +K ++E + ++ L+
Sbjct: 1070 LENDKQQLDERLKKKDF-------EYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEE 1122
Query: 995 DKVESLT 1001
+ E T
Sbjct: 1123 IEAERAT 1129
Score = 34.3 bits (77), Expect = 0.61
Identities = 20/113 (17%), Positives = 58/113 (51%), Gaps = 9/113 (7%)
Query: 895 ERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHS 954
E+ + ++E ++ + EL K +RK +EE L ++++ +++ +++ ++ + D
Sbjct: 847 EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERC 906
Query: 955 ENPLE-------KYMKIIQQEQDQE--SADKSSKKMVQEGSLVDTLQSSDKVE 998
+ ++ K ++ ++ +D+E +A+ ++KK E + + D +E
Sbjct: 907 DQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 959
Score = 32.3 bits (72), Expect = 2.3
Identities = 53/256 (20%), Positives = 105/256 (41%), Gaps = 25/256 (9%)
Query: 778 SRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQ 837
S ++ + +S E+ G+ Q EL K E ++ KL +D EE E+ R+
Sbjct: 1138 SDYARELEELSERLEEAGGVTSTQIELNKKRE-AEFLKLR-RDLEEATLQHEAMVAALRK 1195
Query: 838 LEMGGLSPAGDM--------SHVDAAAAAVPLSYQHPSVDQKQIEEQKEE-EKI---REQ 885
++ G+ ++ + L S + + + K EKI E
Sbjct: 1196 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLED 1255
Query: 886 QVKERRQREERRQSNLQEV------LERERRELEKLYQERKMIEESLKIK----IKKELE 935
Q+ E R + E Q +L E+ L+ E EL + +E++ I L ++ E
Sbjct: 1256 QLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEE 1315
Query: 936 MENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSD 995
++ +LE N + K+ AH+ +++++ ++E K+ + + + Q
Sbjct: 1316 LKRQLEEEN-KAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRT 1374
Query: 996 KVESLTGFSHEELDDS 1011
K E+ EEL+++
Sbjct: 1375 KYETDAIQRTEELEEA 1390
Score = 32.0 bits (71), Expect = 3.0
Identities = 43/205 (20%), Positives = 82/205 (40%), Gaps = 22/205 (10%)
Query: 822 EEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQK---------Q 872
E+ ESS E + LE GD+ A + + L +D++ Q
Sbjct: 1033 EDLESSLEQEKKLRVDLERNKRKLEGDLKL--AQESILDLENDKQQLDERLKKKDFEYCQ 1090
Query: 873 IEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKK 932
++ + E+E+ Q +++ + + R L+E +E ER K ++R L+ ++ +
Sbjct: 1091 LQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELE-ELSE 1149
Query: 933 ELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESA------DKSSKKMVQEGS 986
LE + + E+ K E K + +++ Q A K + + + G
Sbjct: 1150 RLEEAGGVTSTQIELNKK---REAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGE 1206
Query: 987 LVDTLQS-SDKVESLTGFSHEELDD 1010
+D LQ K+E E+DD
Sbjct: 1207 QIDNLQRVKQKLEKEKSEFKLEIDD 1231
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 73.2 bits (178), Expect = 1e-12
Identities = 184/930 (19%), Positives = 381/930 (40%), Gaps = 136/930 (14%)
Query: 103 EKVFTMQDLLQLIKIN----------PTSSLY---KSLVSGSDKENQKGFLMHF---LKE 146
+K+ +D L +I+ N P LY K L+ ++ E + + +KE
Sbjct: 804 KKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMATMKEEFGRIKE 863
Query: 147 LAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQ-------RIKFESLEIK 199
E +A+ E S ++ L ++Q D DA + +I+ E+ +
Sbjct: 864 TLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKE 923
Query: 200 LNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEA 259
+NE + E EE++ AE+ K + +D E +++K + + ELT+ + + EK
Sbjct: 924 MNE-RLEDEEEMNAELTAKKRKLED-ECSELKKDID---DLELTLAKVEKEKHATENKVK 978
Query: 260 LVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDL-------LRGREAELKQRVEAFEL 312
+ E + L+ I E K + Q L D+ + L + +L+Q+V+ E
Sbjct: 979 NLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEG 1038
Query: 313 NQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQ--LELKDDYIIRTNRLIE 370
+ + +++ + A R+ E ++K +E+ L+N+ L+ + L+ K+ I + N IE
Sbjct: 1039 SLEQEKKVRMDLERAKRKLEGDLKLTQESI-MDLENDKLQLEEKLKKKEFDINQQNSKIE 1097
Query: 371 DERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEK 430
DE +++A+ +K+ L ++ R++ELE ELE+ + + K L+ +
Sbjct: 1098 DE------------QVLALQLQKK-LKENQARIEELEEELEAERTARAKVEKLRSDLSRE 1144
Query: 431 VKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAE 490
++E+S E+LE ++ ++ + R A FQK R E
Sbjct: 1145 LEEIS-------ERLEEAGGATSVQIEMNKKRE----------------AEFQKMRRDLE 1181
Query: 491 KAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQ 550
+A + + E+ AL K+ D + A+L QI + + L + ++ KL+L
Sbjct: 1182 EATL----QHEATAAALRKKHADSV---AELGEQIDNLQRVKQKLEKEKSEFKLELDDVT 1234
Query: 551 TALENEVYCNPKQSVIDRSVNGLINGNVVPCN--GEISGDFLNNPFK---QENVLARMVA 605
+ +E + + R++ N V DF K + LAR +
Sbjct: 1235 SNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLE 1294
Query: 606 SR---ITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRS--YHRRVIKNS 660
+ I+ + + DL K +++E + L A +S + +++
Sbjct: 1295 EKEALISQLTRGKLSYTQQMEDL------KRQLEEEGKAKNALAHALQSARHDCDLLREQ 1348
Query: 661 AKSPLAAKSPPSLHLLEAFKNI----TSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEA 716
+ AK+ L +A + T + E+ +++ L++ + VEA
Sbjct: 1349 YEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEA 1408
Query: 717 LTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEM--YLEGLGRSHIASPSPCPDRM---P 771
+ +S L K K L++E+ + + RS+ A+ + +
Sbjct: 1409 VNAKCSS---------------LEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDK 1453
Query: 772 LPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESA 831
+ + + ++ S + S ++ L +L++ E S FK E ++ E
Sbjct: 1454 ILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFK--RENKNLQEEI 1511
Query: 832 GNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVK--E 889
++ QL GG + ++ V L Q ++++ + + EE KI Q++ +
Sbjct: 1512 SDLTEQLGEGGKN-VHELEKVRKQLEVEKLELQ-SALEEAEASLEHEEGKILRAQLEFNQ 1569
Query: 890 RRQREERRQSNLQEVLERERRELEK--------LYQERKMIEESLKIKIKKELEMENELE 941
+ ER+ + E +E+ +R ++ L E + E L++K K E ++ NE+E
Sbjct: 1570 IKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDL-NEME 1628
Query: 942 MSNQEIKDKSAHSENPLEKYMKIIQQEQDQ 971
+ +A ++ ++ +++ Q Q
Sbjct: 1629 IQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 1658
Score = 57.0 bits (136), Expect = 9e-08
Identities = 176/918 (19%), Positives = 371/918 (40%), Gaps = 93/918 (10%)
Query: 115 IKINPTSSLYKSLVSGSDK-ENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLA 173
++ + +SL KS V + ++ +G L K + +AK + + + D
Sbjct: 1014 VEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEN 1073
Query: 174 EKLQL---IDDQFADAYPQRIKFESLEIKLNEYKREIEE-QLRAEMCQKLKFFKDTEIAK 229
+KLQL + + D Q K E ++ + +++++E Q R E ++ + T AK
Sbjct: 1074 DKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAK 1133
Query: 230 IKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQ-- 287
++ + + +EL E+A A S + + +K E +++E + +
Sbjct: 1134 VE-KLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1192
Query: 288 -LLLKDMDLLRGREAELKQRVEAFE-LNQKLQEEKHK---SITEALRRQEQNIKSFE--E 340
L K D + AEL ++++ + + QKL++EK + + + EQ IK+ E
Sbjct: 1193 ALRKKHADSV----AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLE 1248
Query: 341 TYDRKLKNELLKYQLELKD------DYIIRTNRLIEDERKNKEKAVHLQEELIAINS--- 391
R L+++ +Y+++L++ D+ + +L + +N E A L+E+ I+
Sbjct: 1249 KVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKL---QTENGELARQLEEKEALISQLTR 1305
Query: 392 -KKEELNQSVNRVKELELELESVKAQSLAITKQNH---MLNEKVKEMSDYSLLKEEKLEL 447
K Q + ++LE E ++ A + A+ H +L E+ +E ++ K E +
Sbjct: 1306 GKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETE---AKAELQRV 1362
Query: 448 LAQ-NKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQA 506
L++ N + Q + + ++ L + +LA ++ +A +A+ + E +
Sbjct: 1363 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHR 1422
Query: 507 LHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVI 566
L +++D + + A ++ +A+ K + +++Q+ LE+ + +
Sbjct: 1423 LQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESS---QKEARSL 1479
Query: 567 DRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLE 626
+ L N E S + L FK+EN + + I++ EG +LE
Sbjct: 1480 STELFKLKNAY------EESLEHLET-FKREN---KNLQEEISDLTEQLGEGGKNVHELE 1529
Query: 627 FVANTKARVK-ELQQEAERLEKAFRSYHRRVIK-----NSAKSPLAAKSPPSLHLLEAFK 680
V K ELQ E E + ++++ N K+ + K +E K
Sbjct: 1530 KVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAK 1589
Query: 681 NITS---SSPERHIFGEDRVVSEQPQV-----GTLEERN---DVVEALTGSAASRLRGGT 729
S + + E R +E +V G L E + A +++
Sbjct: 1590 RNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQ 1649
Query: 730 SSRRLSSTPLPKAKRSLES-EMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVS 788
S + + L A R+ + + + + R + + + + TE L+ +
Sbjct: 1650 SLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELI 1709
Query: 789 SPPEQKVGLYRRQTEL--QDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPA 846
E+ L+ + T L Q K SD+ +L E E + + N + +
Sbjct: 1710 ETSERVQLLHSQNTSLINQKKKMESDLTQL----QSEVEEAVQECRNAEEKAKK------ 1759
Query: 847 GDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLE 906
+ DAA A L + + +E K K EQ +K+ + R + + Q L+
Sbjct: 1760 ---AITDAAMMAEELKKEQDT--SAHLERMK---KNMEQTIKDLQHRLDEAE---QIALK 1808
Query: 907 RERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQ 966
+++L+KL + +E L+ + K+ E + S + IK+ + +E + +++
Sbjct: 1809 GGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQD 1868
Query: 967 QEQDQESADKSSKKMVQE 984
+ K+ K+ +E
Sbjct: 1869 LVDKLQLKVKAYKRQAEE 1886
Score = 52.4 bits (124), Expect = 2e-06
Identities = 85/398 (21%), Positives = 171/398 (42%), Gaps = 79/398 (19%)
Query: 174 EKLQL---IDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFK------- 223
EKL+L +++ A + K +++ N+ K EIE +L AE ++++ K
Sbjct: 1538 EKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKL-AEKDEEMEQAKRNHQRVV 1596
Query: 224 ---------DTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKH 274
+T + KKK E +L + A + +EA ++ +L+ + K
Sbjct: 1597 DSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQ--KQVKSLQSLLKD 1654
Query: 275 QEIETKEIYAQRQLLLKDM-------DLLRGREAELKQRVEAFELNQKLQEEKHKSITEA 327
+I+ + L +++ +LL+ EL+ VE E ++KL E++ +E
Sbjct: 1655 TQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSER 1714
Query: 328 LRR-QEQNIKSFEETYDRKLKNELLKYQLELKDDY-------------IIRTNRLIEDER 373
++ QN + +K++++L + Q E+++ I + E+ +
Sbjct: 1715 VQLLHSQNTSLINQK--KKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELK 1772
Query: 374 KNKEKAVHLQE-------------------ELIAINSKKEELNQSVNRVKELELELESVK 414
K ++ + HL+ E IA+ K++L + RV+ELE ELE+ +
Sbjct: 1773 KEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQ 1832
Query: 415 AQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQ 474
++ K ++KE++ Y +++K L Q+ + K QL+ ++ R A+
Sbjct: 1833 KRNAESVKGMRKSERRIKELT-YQTEEDKKNLLRLQDLVDKLQLK------VKAYKRQAE 1885
Query: 475 PAPE-----LAVFQK---ELRKAEKAIVVEHEEFESCR 504
A E L+ F+K EL +AE+ + + R
Sbjct: 1886 EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLR 1923
Score = 37.7 bits (86), Expect = 0.055
Identities = 43/222 (19%), Positives = 97/222 (43%), Gaps = 22/222 (9%)
Query: 792 EQKVGLYRRQTELQD-----KSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPA 846
E L ++ +L+D K + D++ K +E ++ N+ EM GL
Sbjct: 933 EMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTE--EMAGLDEI 990
Query: 847 GDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLE 906
++ + A+ ++Q ++D Q+EE K + + + + E++ +L+ LE
Sbjct: 991 --IAKLTKEKKALQEAHQQ-ALDDLQVEEDKVNS------LSKSKVKLEQQVDDLEGSLE 1041
Query: 907 RERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQ 966
+E++ L + ++ +E LK+ + +++EN+ +++K K K
Sbjct: 1042 QEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKI----- 1096
Query: 967 QEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEEL 1008
E +Q A + KK+ + + ++ L+ + E E+L
Sbjct: 1097 -EDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKL 1137
Score = 32.7 bits (73), Expect = 1.8
Identities = 35/149 (23%), Positives = 63/149 (42%), Gaps = 11/149 (7%)
Query: 869 DQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKI 928
D Q + E+E++ Q++++ + + R L+E LE ER K+ + R + L+
Sbjct: 1088 DINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELE- 1146
Query: 929 KIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESA------DKSSKKMV 982
+I + LE E+ K E +K + +++ Q A K + +
Sbjct: 1147 EISERLEEAGGATSVQIEMNKK---REAEFQKMRRDLEEATLQHEATAAALRKKHADSVA 1203
Query: 983 QEGSLVDTLQS-SDKVESLTGFSHEELDD 1010
+ G +D LQ K+E ELDD
Sbjct: 1204 ELGEQIDNLQRVKQKLEKEKSEFKLELDD 1232
Score = 32.3 bits (72), Expect = 2.3
Identities = 30/140 (21%), Positives = 67/140 (47%), Gaps = 10/140 (7%)
Query: 871 KQIEEQKEEEKIREQ--QVKERRQREERRQSNLQE---VLERERRELEKLYQERK----M 921
K E +KE ++E+ ++KE ++ E R+ L+E L +E+ +L+ Q +
Sbjct: 843 KSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLND 902
Query: 922 IEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKM 981
EE IK ++++E +++ N+ ++D+ + K K ++ E + D ++
Sbjct: 903 AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRK-LEDECSELKKDIDDLEL 961
Query: 982 VQEGSLVDTLQSSDKVESLT 1001
+ + +KV++LT
Sbjct: 962 TLAKVEKEKHATENKVKNLT 981
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 72.8 bits (177), Expect = 2e-12
Identities = 130/636 (20%), Positives = 277/636 (43%), Gaps = 90/636 (14%)
Query: 144 LKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEY 203
L+EL H K N Q + L + L+ + + + + L+ +L+E
Sbjct: 651 LEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEM 710
Query: 204 KREIEEQLRAE----------MCQKLKFFKDTEIAKIKME-AKKKYEKELTMFQNDFEKA 252
E++ R+E + Q + +D IAK + E +K E+ELT + ++
Sbjct: 711 HDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEE 770
Query: 253 CQAKSEAL-VLREK--STLERIHKHQEIETK--EIYAQR---------------QLLLKD 292
+ + + L+E+ + L+ + + E TK E+ A R +LL ++
Sbjct: 771 VSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEE 830
Query: 293 MDLLRGREAELKQRVEAFELNQKLQEEK--HKSITEALRRQEQNIKSFEET--YDRKLKN 348
+ L+GR EL++RV +L +++++ K E L++ E I+ EE + RK +
Sbjct: 831 NEKLQGRSEELERRVA--QLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEK 888
Query: 349 ELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKE--- 405
E + + L+++ L + ++ K+ + L+EE + +KE+L + N ++
Sbjct: 889 EAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEE----SEQKEQLRRLKNEMENERW 944
Query: 406 -LELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNE 464
L +E ++ + I + + +++ D ++ + EL + LK++ E+
Sbjct: 945 HLGKTIEKLQKEMADIVEASRTSTLELQNQLD-EYKEKNRRELAEMQRQLKEKTLEAEKS 1003
Query: 465 NLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQ 524
L + E+ + ++ELR ++A +E + RQ L + L+D +E+ + K+
Sbjct: 1004 RLTAMKM----QDEMRLMEEELRDYQRA----QDEALTKRQLLEQTLKD-LEYELEAKSH 1054
Query: 525 ILGYKAS-VKSLTTQVADLKLQLKQTQT---ALENEVYCNPKQSVIDRSVNGLINGNVVP 580
+ ++ VK + +V+ L+++L++ + L + + +Q +++ N L+
Sbjct: 1055 LKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQ--MEQLRNELLQERAA- 1111
Query: 581 CNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQ 640
++ D ++ + +++ +R++ +EGS S V +AR+ EL+
Sbjct: 1112 -RQDLECDKISLERQNKDLKSRIIH----------LEGSYRSSKEGLVVQMEARIAELED 1160
Query: 641 --EAERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHL----------LEAFKNITSSSPE 688
E+E ++A R ++ K + L L L+A K + E
Sbjct: 1161 RLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEE 1220
Query: 689 RHIFGEDRVVSEQPQV-GTLEERNDVVEALTGSAAS 723
DR+ S + ++ LEE+ D+ E L G S
Sbjct: 1221 E----IDRLESSKKKLQRELEEQMDMNEHLQGQLNS 1252
Score = 66.2 bits (160), Expect = 1e-10
Identities = 143/730 (19%), Positives = 283/730 (38%), Gaps = 108/730 (14%)
Query: 254 QAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQ-RVEAFEL 312
+ E+ V+R S + K +E++T A L+L++ ++ K+ V+ F
Sbjct: 474 EGSQESTVIRAPSLGAQSKKEEEVKT----ATATLMLQNRATATSPDSGAKKISVKTFPS 529
Query: 313 NQKLQEEKHKSITEALR-RQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIED 371
Q + + L+ +QE ++ EET + L N L + + D + N + E
Sbjct: 530 ASNTQ-----ATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEK 584
Query: 372 ERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQ-SLAITKQNHMLNEK 430
+ K +A + + E+ + + +L +E+ ++ Q L + Q ++ E+
Sbjct: 585 IQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEER 644
Query: 431 VKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAE 490
+ ++ L+ + E + +N L+Q+LEES E + L L Q E Q E+R +
Sbjct: 645 ERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQ 704
Query: 491 KAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQ 550
+ H+E +S +++ ++ IE Q K + + + + + +L +
Sbjct: 705 DQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALK 764
Query: 551 TALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITN 610
AL+ EV + ++ D L + E R T
Sbjct: 765 GALKEEVSSHDQEM-----------------------DKLKEQYDAELQALRESVEEATK 801
Query: 611 YPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKSPLAAKSP 670
V S ++ + A T+ RVK LQ+E E+L+ RRV + +
Sbjct: 802 --NVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQ-------- 851
Query: 671 PSLHLLEAFKNITSSSPE--RHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGG 728
+E K + + E + GE R + E EE+ V
Sbjct: 852 -----IEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAV--------------- 891
Query: 729 TSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVS 788
A+R+LE+E+ + L T+ + LS +
Sbjct: 892 ------------SARRALENELEAA---------------QGNLSQTTQEQKQLS-EKLK 923
Query: 789 SPPEQKVGLYRRQTELQDKSEF--SDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPA 846
EQK L R + E++++ ++KL + + E+S S + QL+
Sbjct: 924 EESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNR 983
Query: 847 GDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKE--EEKIREQQVKERRQREERRQSNLQEV 904
+++ + L + + +++++ EE++R+ Q R Q E + L E
Sbjct: 984 RELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQ---RAQDEALTKRQLLEQ 1040
Query: 905 ----LERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQE-IKDKSAHSENPLE 959
LE E L +R + + ++ K+ +LEME E E +N + + ++ + S +E
Sbjct: 1041 TLKDLEYELEAKSHLKDDRSRLVKQMEDKV-SQLEMELEEERNNSDLLSERISRSREQME 1099
Query: 960 KYMKIIQQEQ 969
+ + QE+
Sbjct: 1100 QLRNELLQER 1109
Score = 65.9 bits (159), Expect = 2e-10
Identities = 117/519 (22%), Positives = 216/519 (41%), Gaps = 77/519 (14%)
Query: 100 LAKEKVFTMQDLLQLIKINPTS--SLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESC 157
+AKE+ +DLL+ + T+ K VS D+E K L E + A+
Sbjct: 744 IAKEE---QEDLLRKRERELTALKGALKEEVSSHDQEMDK---------LKEQYDAELQA 791
Query: 158 NMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQ 217
E+ +T N + LA + + A + + KL E+E ++ A++ +
Sbjct: 792 LRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRV-AQLQR 850
Query: 218 KLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLR-------------- 263
+++ K E AK K E KKYE E+ + A + + EA+ R
Sbjct: 851 QIEDLKGDE-AKAK-ETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNL 908
Query: 264 ------EKSTLERIHKHQEIETK------EIYAQRQLLLKDMDLLRGREAELKQ--RVEA 309
+K E++ + E + + E+ +R L K ++ L+ A++ + R
Sbjct: 909 SQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTST 968
Query: 310 FELNQKLQEEKHKSITEALRRQEQ-NIKSFEETYDR----KLKNELLKYQLELKD----- 359
EL +L E K K+ E Q Q K+ E R K+++E+ + EL+D
Sbjct: 969 LELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQ 1028
Query: 360 DYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLA 419
D + +L+E K+ E + + L + + + Q ++V +LE+ELE + S
Sbjct: 1029 DEALTKRQLLEQTLKDLEYELEAKSHLK--DDRSRLVKQMEDKVSQLEMELEEERNNSDL 1086
Query: 420 ITKQ--------NHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQ---LEESRNENLRL 468
++++ + NE ++E + L+ +K+ L QNK LK + LE S +
Sbjct: 1087 LSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEG 1146
Query: 469 LNRLAQPAPELAVFQKELRKAEK---AIVVEHEEFESCRQALHKQLQDE----IEHSAQL 521
L + Q +A + L E+ + + + E + L Q+ DE + QL
Sbjct: 1147 L--VVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQL 1204
Query: 522 KAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCN 560
++ K V+ ++ L+ K+ Q LE ++ N
Sbjct: 1205 SLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMN 1243
Score = 65.5 bits (158), Expect = 2e-10
Identities = 171/854 (20%), Positives = 338/854 (39%), Gaps = 134/854 (15%)
Query: 96 PESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKE 155
P+SG K V T + L +++E K L ++LKE
Sbjct: 515 PDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYLKE--------- 565
Query: 156 SCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEM 215
ST N D+ K+ L+ FE ++ + + +A
Sbjct: 566 --------GSTDNDDATKRKVNLV-------------FEKIQTLKSRAAGSAQGNNQA-- 602
Query: 216 CQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQ 275
C KD +E K K E+ Q + L ++ + ++ +
Sbjct: 603 CNSTSEVKDL------LEQKSKLTIEVAELQRQLQ---------LEVKNQQNIKEERERM 647
Query: 276 EIETKEIYAQRQLLLKDMDLLRGR----EAELKQRVEAFELNQ-KLQEEKHKS----ITE 326
+E+ +Q +++ L+ R E EL++ +E EL Q K++ E+H++ + +
Sbjct: 648 RANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLE--ELFQVKMEREQHQTEIRDLQD 705
Query: 327 ALRRQEQNIKSFEETYDRK---LKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVH-- 381
L + S + + DR+ L ELL+ + +L+D I + + ED + +E+ +
Sbjct: 706 QLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQ--EDLLRKRERELTAL 763
Query: 382 ---LQEELIAINSKKEELNQSVNRVKELELELESV----KAQSLAITKQNHMLNEKVKEM 434
L+EE+ + + + ++L + + EL+ ESV K + ++ N ++
Sbjct: 764 KGALKEEVSSHDQEMDKLKEQYDA--ELQALRESVEEATKNVEVLASRSNTSEQDQAGTE 821
Query: 435 SDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIV 494
LL+EE +L +++ L++++ + + + L A+ L ++ E+R+ E+A+V
Sbjct: 822 MRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALV 881
Query: 495 VEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALE 554
+E + A + L++E+E + +Q + + + ++ K QL++ + +E
Sbjct: 882 HARKEEKEAVSA-RRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEME 940
Query: 555 NEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLN--NPFKQENVLARMVASRITNYP 612
NE + K I++ + ++V + + + N + +K++N R
Sbjct: 941 NERWHLGK--TIEKLQKEM--ADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEK 996
Query: 613 TAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKSPLAAKSPPS 672
T E S + ++Q E +E+ R Y R + K L ++
Sbjct: 997 TLEAEKS------------RLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKD 1044
Query: 673 LHL-LEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSS 731
L LEA ++ ED+V Q ++ EERN+ L SR R
Sbjct: 1045 LEYELEAKSHLKDDRSRLVKQMEDKV--SQLEMELEEERNN--SDLLSERISRSR----- 1095
Query: 732 RRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPP 791
+ L +E+ E R + D++ L + S I S
Sbjct: 1096 ---------EQMEQLRNELLQERAARQDLEC-----DKISLERQNKDLKSRIIHLEGSYR 1141
Query: 792 EQKVGLY----RRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAG 847
K GL R EL+D+ E +EE + + N + ++ L
Sbjct: 1142 SSKEGLVVQMEARIAELEDRLE-----------SEERDRANLQLSNRRLERKVKELVMQV 1190
Query: 848 DMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLER 907
D H+ LS + ++ ++Q+EE EEE R + K++ QRE Q ++ E L+
Sbjct: 1191 DDEHLSLTDQKDQLSLRLKAM-KRQVEEA-EEEIDRLESSKKKLQRELEEQMDMNEHLQG 1248
Query: 908 ERRELEKLYQERKM 921
+ ++K + +K+
Sbjct: 1249 QLNSMKKDLRLKKL 1262
Score = 44.7 bits (104), Expect = 5e-04
Identities = 36/145 (24%), Positives = 74/145 (51%), Gaps = 9/145 (6%)
Query: 871 KQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKL-YQERKMIEESLKIK 929
K + EQK + I +++ + Q E + Q N++E ER R LE+L Q + +EE+ ++
Sbjct: 610 KDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQ 669
Query: 930 IKKELEMENELEMSNQEI----KDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEG 985
+ E E E EL + +E+ ++ H + ++ + + +SA +S + ++G
Sbjct: 670 QRLE-ESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDR--EKG 726
Query: 986 SLV-DTLQSSDKVESLTGFSHEELD 1009
+L+ + LQ+ ++ L E+ D
Sbjct: 727 ALIEELLQAKQDLQDLLIAKEEQED 751
Score = 39.7 bits (91), Expect = 0.014
Identities = 53/255 (20%), Positives = 101/255 (39%), Gaps = 54/255 (21%)
Query: 792 EQKVGLYRRQTEL---------QDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGG 842
EQ+ L +R+ EL + S ++DKL + + E ++ ES + +E+
Sbjct: 748 EQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEV-- 805
Query: 843 LSPAGDMSHVDAAAAAVPLSYQHPSVDQ------------KQIEEQKEEEKIREQQVKER 890
L+ + S D A + + ++ Q++ Q E+ K E + KE
Sbjct: 806 LASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKET 865
Query: 891 RQREERRQSNLQEVLERERRELEKLYQERKMIEESLKI-----------------KIKKE 933
++ E L+E L R+E ++ R+ +E L+ K+K+E
Sbjct: 866 LKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEE 925
Query: 934 LEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQS 993
E + +L E++++ H +EK K E AD + E S TL+
Sbjct: 926 SEQKEQLRRLKNEMENERWHLGKTIEKLQK--------EMAD------IVEASRTSTLEL 971
Query: 994 SDKVESLTGFSHEEL 1008
++++ + EL
Sbjct: 972 QNQLDEYKEKNRREL 986
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 72.8 bits (177), Expect = 2e-12
Identities = 170/798 (21%), Positives = 318/798 (39%), Gaps = 135/798 (16%)
Query: 28 KDRGILDTLKTQLRNQLIH-ELMHPVLSGELQPRSISVE--GSSLLIGASNS--LVADHL 82
K+R L T +LR +LI E + L + R+ + LL ASNS L ++
Sbjct: 634 KERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMT 693
Query: 83 QRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMH 142
++C +L E +A + L+ + + +SL + + E++K L
Sbjct: 694 KKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKI-RSLETNINTEHEKICLAF 752
Query: 143 FLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFA-----------DAYPQRI 191
+ Q KE ME Q + L +L+ D QF D ++
Sbjct: 753 EKAKKIHLEQHKE---MEKQI------ERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQH 803
Query: 192 KFESLEIKLNEYKREI--EEQLRAEMCQKLKFFKDTEIAKIKM--EAKKKYEKELTMFQN 247
ESL+ L E K E+ E + E + L+ E K++ A + ++EL + N
Sbjct: 804 HLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLN 863
Query: 248 D-------FEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQ-----RQLLLKDMDL 295
FEK + KSE + +K + H QE + + Q +Q +L+ +
Sbjct: 864 QLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETI 923
Query: 296 LRGR--EAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYD---------- 343
G + + K + +L Q+LQ+++ S E LR+ E+ +S D
Sbjct: 924 RNGELEDTQTKLEKQVSKLEQELQKQRESS-AEKLRKMEEKCESAAHEADLKRQKVIELT 982
Query: 344 ---RKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSV 400
R++K E+ +Y+ EL ++ +R + KA+HL + + ++ K EL +
Sbjct: 983 GTARQVKIEMDQYKEELSK----MEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKT 1038
Query: 401 NRVKELELELESVKAQSLAITKQNHMLN--------------EKVKEMSDY----SLLKE 442
N VKELE S + + ++ +L +++E+ D L E
Sbjct: 1039 NAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLE 1098
Query: 443 EKL----ELLAQNKLLKQQLEESRNENLRLLNRLAQPAPEL------------------A 480
EK +L A+ + K ++E+ + E L + L + EL
Sbjct: 1099 EKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRG 1158
Query: 481 VFQKELRKAEKAIVVEHEEFESCR---QALHKQLQDEIEHSAQLKAQILGYKASVKSLTT 537
++++ K E + E + C ++L+ +LQ+ E + + +L + + L
Sbjct: 1159 EMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKK 1218
Query: 538 QVADLKLQLKQTQTAL-ENEVY-CNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFK 595
++ + ++K+ ++ + E E Y + ID + V + + + +
Sbjct: 1219 EIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQ 1278
Query: 596 QENVLARMVASRITNYPTAWVE------------GSSPDSDLEFVANTKARVKELQQEAE 643
+ + R+ +S + + E G+S + A +A +K+L E E
Sbjct: 1279 AQREIERL-SSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVE 1337
Query: 644 RLEKAFRSYHRRVI---KNSAKSPLAAKSPPS--LHLLEAFKNITSSSPERHIFGEDRVV 698
L++A YH +I +N AK ++A S S L E + E +D V
Sbjct: 1338 SLKEA---YHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEE----AQDTVS 1390
Query: 699 SEQPQVGTLEERNDVVEA 716
+ QV ++RN+V+EA
Sbjct: 1391 NLHQQV---QDRNEVIEA 1405
Score = 68.6 bits (166), Expect = 3e-11
Identities = 182/923 (19%), Positives = 364/923 (39%), Gaps = 152/923 (16%)
Query: 152 QAKESCNMETQTSST-FNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQ 210
Q K+ E Q + +N + L++ Q + A+ ++++ E ++ N E E +
Sbjct: 345 QTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKL-EKVQAEEEILERNLTNCEKENK 403
Query: 211 LRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLER 270
E C K + EI K K+ ++ ++E + SE + +S
Sbjct: 404 RLQERCGLYK--SELEILKEKL---RQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSI 458
Query: 271 IHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRR 330
+ E+E K+ +L+D L ELK RV A L +++ +S LR
Sbjct: 459 LKLESELENKDE------ILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRS 512
Query: 331 QEQNIKSFEETYDRKL---KNELLKYQLEL---KDDYII---RTNRLIEDERKNKEKAVH 381
E+ I R+L K+ L KYQ+ K+D I N+L+ E + K
Sbjct: 513 LEKIISQLP--LKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKE 570
Query: 382 LQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLK 441
+ + + N +L+QS+ + + + ++ + H + E VK+ + +++ K
Sbjct: 571 AEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNK 630
Query: 442 E---EKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKEL-RKAEKAIVVEH 497
+ E+ L+ + L+ +L + EN L +A + + Q+EL KA + +E
Sbjct: 631 QYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLES 690
Query: 498 EEFESCRQ--ALHKQLQDEI-------EHSAQLKAQILGYKASVKSLTT----------- 537
E + C Q L KQL+++I +A+L+ +++ ++SL T
Sbjct: 691 EMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICL 750
Query: 538 ------------------QVADLKLQLKQ----------TQTALENEVYCNPKQSVIDRS 569
Q+ L+ QL++ T + L+ ++ C KQ ++ S
Sbjct: 751 AFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIIC--KQHHLE-S 807
Query: 570 VNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVA 629
++ L+ E G+ K++ L + + ++++ ++ DS LE
Sbjct: 808 LDRLLT--------ESKGEMKKENMKKDEAL-KALQNQVSEET---IKVRQLDSALEICK 855
Query: 630 NTKA-RVKELQQEAERLEKAFRSYHRRV--------IKNSAKSPLAAKSPPSLHLLEAFK 680
+ +L+ E+ EK + V IKN + + ++ H L+ +
Sbjct: 856 EELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQ 915
Query: 681 NITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLP 740
+ R+ ED + QV LE+ ++ S+A +LR
Sbjct: 916 QMLQQETIRNGELEDTQTKLEKQVSKLEQE---LQKQRESSAEKLR-------------- 958
Query: 741 KAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRR 800
K + ES + L R + + ++ + S E+++ +R
Sbjct: 959 KMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEEL-------SKMEKEIMHLKR 1011
Query: 801 QTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVP 860
E S +D + ++ ++ E N ++LE S +++
Sbjct: 1012 DGE-NKAMHLSQLDMIL----DQTKTELEKKTNAVKELEKLQHSTETELTE--------- 1057
Query: 861 LSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERK 920
+ Q V + +++ E K +Q++E R ++ Q +L+E + ++ L E +
Sbjct: 1058 -ALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEE----KYTTIKDLTAELR 1112
Query: 921 MIEESLKIKIKKELEMENELEMSNQEIKDKSAH--------SENPLEKYMKIIQQEQDQE 972
+ ++ K ++ LEM+ L+ N E+K ++A E+ E KII+ E E
Sbjct: 1113 ECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLE 1172
Query: 973 SADKSSKKM-VQEGSLVDTLQSS 994
++ K+ Q SL D LQ++
Sbjct: 1173 KSELELKECNKQIESLNDKLQNA 1195
Score = 67.0 bits (162), Expect = 8e-11
Identities = 193/1015 (19%), Positives = 396/1015 (39%), Gaps = 163/1015 (16%)
Query: 83 QRCG-YEYSLSVFFP-------ESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKE 134
+RCG Y+ L + E+ KEK+ M + T S L S+ E
Sbjct: 407 ERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELE 466
Query: 135 NQ------KGFLMHFLKEL----AEYHQAKESCNMETQTSSTFNR--DSLAEKLQLIDDQ 182
N+ K LM+ +EL A ++ + C E ++S R + + +L L +
Sbjct: 467 NKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKREL 526
Query: 183 FA-DAYPQRIKFESLEIKLN------EYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAK 235
F +Y + + S K + E + + +LR ++ K+ EI K+
Sbjct: 527 FGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLA-----IKEAEIQKLHANLT 581
Query: 236 KKYEKELTMFQNDFEKACQAKS---EALVLREKSTLERIH-KHQEIETKEIYAQRQLLLK 291
+ + ND +++ + S E + L E + ++Q K+ +RQ L+
Sbjct: 582 ANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVT 641
Query: 292 DMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNEL- 350
++ LR + +++ ++N + + + I E L + N E +K L
Sbjct: 642 GIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLT 701
Query: 351 LKYQLELKD---DYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELE 407
L+ QLE K I N +E E K + + E IN++ E++ + + K++
Sbjct: 702 LEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLET--NINTEHEKICLAFEKAKKIH 759
Query: 408 LE--------LESVKAQSLAITKQNHMLNEKVKEMSDYS---LLKEEKLELLAQNKLLKQ 456
LE +E ++AQ + K++ E+ K MS + K+ LE L ++LL +
Sbjct: 760 LEQHKEMEKQIERLEAQ---LEKKDQQFKEQEKTMSMLQQDIICKQHHLESL--DRLLTE 814
Query: 457 QLEESRNENLR-------LLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHK 509
E + EN++ L N++++ ++ L ++ +V+ + E ++ K
Sbjct: 815 SKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEK 874
Query: 510 QLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRS 569
QL+ + E L+ ++ S++ + Q L+ L+Q Q L+ E
Sbjct: 875 QLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIR---------- 924
Query: 570 VNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVA 629
NG + ++S +QE R ++ E ++ ++DL+
Sbjct: 925 -NGELEDTQTKLEKQVS------KLEQELQKQRESSAEKLRKMEEKCESAAHEADLK--- 974
Query: 630 NTKARVKELQQEAERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPER 689
+ +V EL A +++ Y K L+ +HL +N
Sbjct: 975 --RQKVIELTGTARQVKIEMDQY---------KEELSKMEKEIMHLKRDGEN-----KAM 1018
Query: 690 HIFGEDRVVSEQPQVGTLEERNDVV---EALTGSAASRLRGGTSSRRLSSTPLPKAKRSL 746
H+ D ++ + LE++ + V E L S + L R + T L A L
Sbjct: 1019 HLSQLDMILDQTKT--ELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGEL 1076
Query: 747 ESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRR-QTELQ 805
+S + ++ + LS+ + + R + E++
Sbjct: 1077 KSTLR-----------------QLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIE 1119
Query: 806 DKS-EFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQ 864
DK E ++D+ + N E + + L+M G+M + + + +
Sbjct: 1120 DKKQELLEMDQALKERNWELKQRAAQVTH----LDMTIREHRGEM---EQKIIKLEGTLE 1172
Query: 865 HPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEE 924
++ K+ +Q E + Q KE+ + +E ++ + + ++E+E+ Q K +E
Sbjct: 1173 KSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMES 1232
Query: 925 SLK-------IKIKKELEMENELEMSNQEIKD----------KSAHSENPLEKY------ 961
+K + K+ +++ EL ++ +++++ + ++ +E+
Sbjct: 1233 VMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELED 1292
Query: 962 MKIIQQEQDQES---ADKSSKKMVQEGSLVDTLQS-----SDKVESLTGFSHEEL 1008
MK + +E+D A++ V+E L +Q+ S +VESL H E+
Sbjct: 1293 MKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEM 1347
Score = 56.6 bits (135), Expect = 1e-07
Identities = 178/944 (18%), Positives = 362/944 (38%), Gaps = 196/944 (20%)
Query: 189 QRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQND 248
Q K E +++K+ + + ++ RAE + + E++K + KKK ++L Q
Sbjct: 329 QESKEECIKLKV-DLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQ-- 385
Query: 249 FEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVE 308
E+ LER + E E K + + L ++++L+ + +LK+
Sbjct: 386 --------------AEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENN 431
Query: 309 AFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRK-----------LKNELLKYQLEL 357
+ ++ K+ + L Q+I E + K +N LK ++
Sbjct: 432 NGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAA 491
Query: 358 KDDYIIRTNRLIEDER---KNKEKAVH---LQEELIAINS--KKEELNQSVNR------- 402
+++ + + IE R ++ EK + L+ EL S K +++ N+
Sbjct: 492 QNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGC 551
Query: 403 ----------------VKELELE---------------------LESVKAQSL---AITK 422
+KE E++ ES K SL +
Sbjct: 552 CEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKL 611
Query: 423 QNHMLNEKVKEMSDYSLLKE---EKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPEL 479
H + E VK+ + +++ K+ E+ L+ + L+ +L + EN L +A +
Sbjct: 612 GGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQF 671
Query: 480 AVFQKE-LRKAEKAIVVEHEEFESCRQ--ALHKQLQDEI-------EHSAQLKAQILGYK 529
+ Q+E L KA + +E E + C Q L KQL+++I +A+L+ +++
Sbjct: 672 QLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKN 731
Query: 530 ASVKSLTT-----------------------------QVADLKLQL----------KQTQ 550
++SL T Q+ L+ QL ++T
Sbjct: 732 EKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTM 791
Query: 551 TALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITN 610
+ L+ ++ C KQ ++ S++ L+ E G+ K++ L + + ++++
Sbjct: 792 SMLQQDIIC--KQHHLE-SLDRLLT--------ESKGEMKKENMKKDEAL-KALQNQVSE 839
Query: 611 YPTAWVEGSSPDSDLEFVANTKA-RVKELQQEAERLEKAFRSYHRRV--------IKNSA 661
++ DS LE + +L+ E+ EK + V IKN +
Sbjct: 840 ---ETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHS 896
Query: 662 KSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSA 721
+ ++ H L+ + + R+ ED + QV LE+ ++ S+
Sbjct: 897 LQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQE---LQKQRESS 953
Query: 722 ASRLR----------GGTSSRRLSSTPLPKAKRSLESEM--YLEGLGRSHIASPSPCPDR 769
A +LR +R L R ++ EM Y E L + +
Sbjct: 954 AEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKME-------KEI 1006
Query: 770 MPLPSPTE------SRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKD--N 821
M L E S+ + + + E+K + +LQ +E + L ++
Sbjct: 1007 MHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLE 1066
Query: 822 EEFESSFESAGNMPRQL-EMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEE 880
E +++ + RQL E+ + +S + L+ + + +IE++K+E
Sbjct: 1067 TELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELREC-KMEIEDKKQEL 1125
Query: 881 KIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENEL 940
+Q +KER ++R + + + R ++ Q+ +E +L+ K ELE++ E
Sbjct: 1126 LEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLE---KSELELK-EC 1181
Query: 941 EMSNQEIKDKSAHSENPL-EKYMKIIQQEQDQESADKSSKKMVQ 983
+ + DK +++ L EK ++Q EQ+ K ++ Q
Sbjct: 1182 NKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQ 1225
Score = 40.0 bits (92), Expect = 0.011
Identities = 150/743 (20%), Positives = 282/743 (37%), Gaps = 119/743 (16%)
Query: 310 FELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELK-DDYIIRT--N 366
FEL Q + S+ E+ ++Q ++ EE +++ + E+ D ++R N
Sbjct: 264 FELTQSRAKV---SMLESAQQQAASVPILEE--------QIINLEAEVSAQDKVLREAEN 312
Query: 367 RLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHM 426
+L + ++ EK LQE SK+E + V+ LE K A ++N
Sbjct: 313 KLEQSQKMVIEKEQSLQE------SKEECIKLKVDL-------LEQTKQGKRAERQRNEA 359
Query: 427 L---NEKVKEMSDYSLLKEEKLE-LLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVF 482
L E K Y EKLE + A+ ++L++ L EN RL R EL +
Sbjct: 360 LYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEIL 419
Query: 483 QKELRKAE----------KAIVVEHEE----FESCRQALHKQLQDEIEHSAQLKAQILGY 528
+++LR+ + + + V++ E RQ++ K L+ E+E+ ++
Sbjct: 420 KEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILK-LESELENKDEILRDKFSL 478
Query: 529 KASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGD 588
+ L +VA +L Q +E+ V RS+ +I + +P E+ G
Sbjct: 479 MNENRELKVRVAAQNERLDLCQQEIES-------SRVELRSLEKII--SQLPLKRELFG- 528
Query: 589 FLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKA 648
FK + L++ S +N + + + K +KE + +
Sbjct: 529 -----FK--SYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLT 581
Query: 649 FRSYHRRVI-----KNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQ 703
+ +I + S+K P L + +++ + +H + Q
Sbjct: 582 ANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQN--QHTMNKQYEKERQRL 639
Query: 704 VGTLEERND---VVEALTGSAASRLRGGTSSRRL-SSTPLPKAKRS--LESEMYLEGLGR 757
V +EE +EA + TS +L L KA S LESEM
Sbjct: 640 VTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEM------- 692
Query: 758 SHIASPSPCPDRMPLPSPTESR--HSLSIPPVSSPPEQKV-----GLYRRQTELQDKSE- 809
C + L E + SI ++ EQ++ + +T + + E
Sbjct: 693 -----TKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEK 747
Query: 810 ----FSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQH 865
F K+ + ++E E E + QLE + + H
Sbjct: 748 ICLAFEKAKKIHLEQHKEMEKQIE---RLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHH 804
Query: 866 PSVDQKQIEEQKEE---EKIREQQVKERRQREERRQS----NLQEVLERERREL----EK 914
+ + E K E E +++ + + Q + ++ L LE + EL +
Sbjct: 805 LESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQ 864
Query: 915 LYQERKMIEESLKIKIKKELEMENELEMSN---QEIKDKSAHSENPLEKYMKIIQQE--Q 969
L ++ E+ LK K ++ ++ EL++ N QE +++ ++ L++ +++QQE +
Sbjct: 865 LEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIR 924
Query: 970 DQESADKSSKKMVQEGSLVDTLQ 992
+ E D +K Q L LQ
Sbjct: 925 NGELEDTQTKLEKQVSKLEQELQ 947
Score = 33.9 bits (76), Expect = 0.80
Identities = 38/145 (26%), Positives = 68/145 (46%), Gaps = 19/145 (13%)
Query: 875 EQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLK--IKIKK 932
EQ ++ K E+Q E E Q+ ++ +LEK+ E +++E +L K K
Sbjct: 344 EQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENK 403
Query: 933 ELE-----MENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSL 987
L+ ++ELE+ ++++ + N EK ++I+ A K+S+ M Q L
Sbjct: 404 RLQERCGLYKSELEILKEKLRQLKEENNNGKEK-LRIM--------AVKNSEVMAQ---L 451
Query: 988 VDTLQSSDKVESLTGFSHEELDDSW 1012
++ QS K+ES E L D +
Sbjct: 452 TESRQSILKLESELENKDEILRDKF 476
Score = 31.6 bits (70), Expect = 3.9
Identities = 35/151 (23%), Positives = 64/151 (42%), Gaps = 18/151 (11%)
Query: 871 KQIEEQKEEEKIREQQVKERRQREERRQSNL---QEVLERERRELEKLYQERKMIEESLK 927
+++E+ + EE+I E+ + + +R Q + LE + +L +L +E +E L+
Sbjct: 379 EKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLR 438
Query: 928 IKIKKE--------------LEMENELEMSNQEIKDK-SAHSENPLEKYMKIIQQEQDQE 972
I K L++E+ELE ++ ++DK S +EN K Q E+
Sbjct: 439 IMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDL 498
Query: 973 SADKSSKKMVQEGSLVDTLQSSDKVESLTGF 1003
+ V+ SL + L GF
Sbjct: 499 CQQEIESSRVELRSLEKIISQLPLKRELFGF 529
Score = 30.4 bits (67), Expect = 8.8
Identities = 53/274 (19%), Positives = 101/274 (36%), Gaps = 18/274 (6%)
Query: 748 SEMYLEGLGRS-HIASPSPCPDRMPLPSPTESRHSLSIPPVS------SPPEQKVGLYRR 800
+E L+ LG SPS D P PS +E + L + P SP E +
Sbjct: 150 TEWSLQSLGEELSSVSPSENSDYAPNPSRSE-KLILDVQPSHPGLLNYSPYENVCKISGS 208
Query: 801 QTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQ-----LEMGGLSPAGDMSHVDAA 855
T+ Q K A D +E +S E + +Q + L + H +
Sbjct: 209 STDFQKKPRDKMFSSSAPVD-QEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELT 267
Query: 856 AAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKL 915
+ +S + Q EE+ I + + + R N E ++ E E+
Sbjct: 268 QSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQS 327
Query: 916 YQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESAD 975
QE K LK+ + ++ + E E + ++Y K + ++ ++ A+
Sbjct: 328 LQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAE 387
Query: 976 KSSKKMVQEGSLVDTLQSSDKVESLTGFSHEELD 1009
+ + E +L + + + +++ G EL+
Sbjct: 388 EE----ILERNLTNCEKENKRLQERCGLYKSELE 417
>gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens]
Length = 1080
Score = 72.8 bits (177), Expect = 2e-12
Identities = 119/477 (24%), Positives = 199/477 (41%), Gaps = 85/477 (17%)
Query: 125 KSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLI----- 179
+ L + KE +K L L+ E+++A ++ ++ L+EK + +
Sbjct: 595 RDLTARRVKETEKA-LSRQLQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELK 653
Query: 180 --DDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAE--MCQKLKFFKDTEIAKIKMEAK 235
D + + Q LEIK + E+ R E + +K K K+ + ++ E +
Sbjct: 654 QEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQ 713
Query: 236 KK--------------YEKELTMFQNDFEKACQAKSEAL---VLREKSTL---------E 269
K +E EL + C ++E L + REK L +
Sbjct: 714 KLIARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQ 773
Query: 270 RIHKHQEIETKEIYAQRQLLLKDMDLLRGR--EAELKQRVEAFELNQKLQEEKHKSITEA 327
R +H E E + QRQ L ++ R R + +QR E EL Q+L EE ++T A
Sbjct: 774 RFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQL-EESSSALTRA 832
Query: 328 LRRQEQNIKSFEETYDRKLKNEL--LKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEE 385
LR + + E +R+ + EL LK QLEL+ + E R KE+A L E
Sbjct: 833 LRAE---FEKGREEQERRHQMELNTLKQQLELE-------RQAWEAGRTRKEEAWLLNRE 882
Query: 386 LIAINSKKEELNQSVNRVKELELELESVKA-QSLAITKQNHMLNEKVKEMSD-----YSL 439
+EE+ + R KE+EL + ++A +LA + ++K + D S
Sbjct: 883 ----QELREEIRK--GRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSE 936
Query: 440 LKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEE 499
L++ + +L + LK QL E+ ENLRL Q +R+ E+A+
Sbjct: 937 LEQSERKLQERCSELKGQLGEAEGENLRL--------------QGLVRQKERAL------ 976
Query: 500 FESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQTQTALENE 556
QA+++QL E + AQ+ Q + + T+ A +L Q + LE E
Sbjct: 977 --EDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQAKAELATLQARQQLELE 1031
Score = 31.2 bits (69), Expect = 5.2
Identities = 46/225 (20%), Positives = 100/225 (44%), Gaps = 16/225 (7%)
Query: 132 DKENQKGFLMHFLKELAEYH-QAKESCNMETQTSSTFNRDS-LAEKLQLIDDQFADAYPQ 189
++E + ++ LK+ E QA E+ + + NR+ L E+++ D+ +
Sbjct: 843 EQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIELVIH 902
Query: 190 RIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEK--ELTMFQN 247
R++ + K E E+ ++L+ + E+++++ +K E+ EL
Sbjct: 903 RLEADMALAK------EESEKAAESRIKRLRDKYEAELSELEQSERKLQERCSELKGQLG 956
Query: 248 DFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDM-DLLRGREAELKQ- 305
+ E + + LV +++ LE E + E Q++ ++ D L E E +Q
Sbjct: 957 EAEGE-NLRLQGLVRQKERALEDAQAVNEQLSSERSNLAQVIRQEFEDRLAASEEETRQA 1015
Query: 306 --RVEAFELNQKLQ-EEKHKSITEALRRQEQNIKSFEETYDRKLK 347
+ + Q+L+ EE H+ + AL R+E+ + S ++ +K
Sbjct: 1016 KAELATLQARQQLELEEVHRRVKTALARKEEAVSSLRTQHEAAVK 1060
Score = 30.4 bits (67), Expect = 8.8
Identities = 22/101 (21%), Positives = 47/101 (46%), Gaps = 1/101 (0%)
Query: 861 LSYQHPSVDQKQIEEQKEEEKIREQQVKERRQRE-ERRQSNLQEVLERERRELEKLYQER 919
L Q +++ ++ E+E+ QQ ++R E + L + R+R ELE+L Q+
Sbjct: 763 LGQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERERLGQQAARQRAELEELRQQL 822
Query: 920 KMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEK 960
+ +L ++ E E E + +++ + + LE+
Sbjct: 823 EESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELER 863
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 72.4 bits (176), Expect = 2e-12
Identities = 115/522 (22%), Positives = 213/522 (40%), Gaps = 74/522 (14%)
Query: 145 KELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYK 204
+EL E + E T N+ AE +L D +L K +
Sbjct: 1144 RELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSM 1203
Query: 205 REIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEA---LV 261
E+ EQ+ K K K+ K++ + + ++ + + EK C++ + L
Sbjct: 1204 AELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELK 1263
Query: 262 LREKSTLERIH----KHQEIETKEIYAQRQLLLKDM---DLLRGREAELKQRVEAFELNQ 314
+E+ I+ + ++T+ RQL KD L R ++A +Q +E EL
Sbjct: 1264 TKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQ-IE--ELKH 1320
Query: 315 KLQEEKH--KSITEALRRQEQNIKSFEETYDR-------------KLKNELLKYQLELKD 359
+L+EE ++ AL+ + E Y+ K +E+ +++ + +
Sbjct: 1321 QLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYET 1380
Query: 360 DYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSV----NRVKELELELESVKA 415
D I RT L E ++K ++ +E + A+N+K L ++ N V++L L++E A
Sbjct: 1381 DAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNA 1440
Query: 416 QSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNK--------LLK---------QQL 458
A+ K+ ++ + E +E + EL A K L K QL
Sbjct: 1441 ACAALDKKQRNFDKVLSEWKQK--YEETQAELEASQKESRSLSTELFKVKNVYEESLDQL 1498
Query: 459 EESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCR-QALHKQLQDEIEH 517
E R EN L ++ ++A K++ + EK + + E E C QA ++ + +EH
Sbjct: 1499 ETLRRENKNLQQEISDLTEQIAEGGKQIHELEK--IKKQVEQEKCEIQAALEEAEASLEH 1556
Query: 518 SAQLKAQILGYKASVKSLTTQVADLKL--------QLKQTQTALENEVYCNPKQSVIDRS 569
+ +IL + + + ++V D K+ QLK+ T + + QS +D
Sbjct: 1557 E---EGKILRIQLELNQVKSEV-DRKIAEKDEEIDQLKRNHTRVVETM-----QSTLDAE 1607
Query: 570 VNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNY 611
+ + + ++ GD LN Q N R+ A + NY
Sbjct: 1608 IRS--RNDALRVKKKMEGD-LNEMEIQLNHANRLAAESLRNY 1646
Score = 70.5 bits (171), Expect = 8e-12
Identities = 172/866 (19%), Positives = 336/866 (38%), Gaps = 147/866 (16%)
Query: 200 LNEYKREIEEQ---LRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAK 256
L + K ++E+Q L + Q+ K D E AK K+E K +E TM D E Q
Sbjct: 1023 LTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTM---DMENDKQQL 1079
Query: 257 SEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKL 316
E L +E I K ++ + EI Q+++ L+ R EL + +EA ++
Sbjct: 1080 DEKLEKKEFEISNLISKIEDEQAVEIQLQKKI-----KELQARIEELGEEIEAERASRAK 1134
Query: 317 QEEKHKSITEALRRQEQNIK------SFEETYDRKLKNELLKYQLELKDDYIIRTNRLIE 370
E++ ++ L + ++ S + ++K + E K + +L++ + +
Sbjct: 1135 AEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAA 1194
Query: 371 DERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEK 430
+K+ + L E++ + K++L + + EL++E + + + + AI+K L +
Sbjct: 1195 LRKKHADSMAELGEQIDNLQRVKQKLEKEKS---ELKMETDDLSSNAEAISKAKGNLEKM 1251
Query: 431 VKEMSDY-SLLKEEKLE-------LLAQNKLLKQQLEE---SRNENLRLLNRLA------ 473
+ + D S LK ++ E L AQ L+ + E +E L+++L+
Sbjct: 1252 CRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAS 1311
Query: 474 -QPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQI------- 525
Q EL +E KA+ A+ + L +Q ++E E A+L+ +
Sbjct: 1312 TQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEV 1371
Query: 526 ----LGYKASVKSLTTQVADLKLQLKQT-QTALENEVYCNPKQSVIDRSVNGLINGNVVP 580
Y+ T ++ + K +L Q Q A E+ N K + ++++ L N
Sbjct: 1372 AQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQN----- 1426
Query: 581 CNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQ 640
E+ L+ ++ N + + N+ + ++ K + +E Q
Sbjct: 1427 ---EVEDLMLD--VERSNAACAALDKKQRNFD-------------KVLSEWKQKYEETQA 1468
Query: 641 EAERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSE 700
E E +K RS + K + SL LE + + + +++
Sbjct: 1469 ELEASQKESRSLSTELFK------VKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEG 1522
Query: 701 QPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHI 760
Q+ LE+ VE + L +A+ SLE E EG
Sbjct: 1523 GKQIHELEKIKKQVE--------------QEKCEIQAALEEAEASLEHE---EG------ 1559
Query: 761 ASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKD 820
R L + V S ++K+ + + ++ V+ +
Sbjct: 1560 ---------------KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTL 1604
Query: 821 NEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEE 880
+ E S A + +++E ++H + AA +Y++ K+ + ++
Sbjct: 1605 DAEIRSR-NDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDA 1663
Query: 881 KIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESL-------------- 926
++ +KE+ ERR + LQ +E LE+ + RK+ E+ L
Sbjct: 1664 LRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQN 1723
Query: 927 --KIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKII----------QQEQDQESA 974
I KK+L EN++ E+++ S N EK K I ++EQD +
Sbjct: 1724 TSLINTKKKL--ENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAH 1781
Query: 975 DKSSKKMVQEGSLVDTLQSSDKVESL 1000
+ KK +++ ++ D D+ E L
Sbjct: 1782 LERMKKNLEQ-TVKDLQHRLDEAEQL 1806
Score = 59.3 bits (142), Expect = 2e-08
Identities = 159/809 (19%), Positives = 329/809 (40%), Gaps = 106/809 (13%)
Query: 209 EQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMF--QNDFEKACQAKSEALVLRE-- 264
E+ A M ++ + KD E+AK + + K+ EK +T+ +ND + Q+++++L E
Sbjct: 849 EKEMATMKEEFQKTKD-ELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEER 907
Query: 265 ---------------KSTLERIHKHQEIETKEIYAQRQL------LLKDMDLLRGREAEL 303
K ER + +EI + +R+L L KD+D L A++
Sbjct: 908 CEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKV 967
Query: 304 KQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYII 363
++ A E K E+ + E + + + K+ +ET+ + L + L+ ++D
Sbjct: 968 EKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDD------LQAEED--- 1018
Query: 364 RTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVK-ELELELESVKAQSLAITK 422
+ N L + + K +++ L+ L ++++L + R K +LE +L+ + ++ +
Sbjct: 1019 KVNILTKAKTKLEQQVDDLEGSL----EQEKKLRMDLERAKRKLEGDLKLAQESTMDMEN 1074
Query: 423 QNHMLNEKV--KEMSDYSLLK----EEKLELLAQNKL--LKQQLEE----------SRNE 464
L+EK+ KE +L+ E+ +E+ Q K+ L+ ++EE SR +
Sbjct: 1075 DKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAK 1134
Query: 465 NLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQD-EIEHSAQLKA 523
+ + L++ E++ +E A A V +++ E+ Q L + L++ ++H A + A
Sbjct: 1135 AEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAA 1194
Query: 524 QILGYKASVKSLTTQVADL-----KLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNV 578
+ S+ L Q+ +L KL+ ++++ +E + + +++ G +
Sbjct: 1195 LRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAI--SKAKGNLEKMC 1252
Query: 579 VPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKEL 638
++S + +Q+ ++ + A R A D V+ +
Sbjct: 1253 RSLEDQVS-ELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAS 1311
Query: 639 QQEAERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLH----LLEAFKNITSSSPERHIFGE 694
Q+ E L+ H+ + AK+ LA S H L E ++ E
Sbjct: 1312 TQQIEELK------HQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQ-RAL 1364
Query: 695 DRVVSEQPQVGTLEE-----RNDVVEALTGSAASRLRGG---TSSRRLSSTPLPKAKRSL 746
+ SE Q T E R + +E A RL+ + L K K+ L
Sbjct: 1365 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRL 1424
Query: 747 ESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQD 806
++E +E L S + C + + V S +QK + + E
Sbjct: 1425 QNE--VEDLMLDVERSNAAC--------AALDKKQRNFDKVLSEWKQKYEETQAELEASQ 1474
Query: 807 KSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHP 866
K S +L FK +E S + + R+ + ++S + A
Sbjct: 1475 KESRSLSTEL-FKVKNVYEESLDQLETLRRE----NKNLQQEISDLTEQIAEGGKQIHEL 1529
Query: 867 SVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESL 926
+KQ+E++K E + ++ + + EE + +Q L + + E+++ E+ + L
Sbjct: 1530 EKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQL 1589
Query: 927 KIKIKKELE-----MENELEMSNQEIKDK 950
K + +E ++ E+ N ++ K
Sbjct: 1590 KRNHTRVVETMQSTLDAEIRSRNDALRVK 1618
Score = 52.0 bits (123), Expect = 3e-06
Identities = 74/378 (19%), Positives = 163/378 (43%), Gaps = 78/378 (20%)
Query: 192 KFESLEIKLNEYKREIE----------EQLRAEMCQKLKFFKDTEIAKIK-----MEAKK 236
K ++++LN+ K E++ +QL+ + ++ + T A+I+ + KK
Sbjct: 1560 KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKK 1619
Query: 237 KYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIET-------KEIYAQRQLL 289
K E +L + A + +E+L R + I K ++ +++ Q ++
Sbjct: 1620 KMEGDLNEMEIQLNHANRLAAESL--RNYRNTQGILKETQLHLDDALRGQEDLKEQLAIV 1677
Query: 290 LKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNE 349
+ +LL+ EL +E E ++K+ E++ +E ++ S T +KL+N+
Sbjct: 1678 ERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINT-KKKLEND 1736
Query: 350 LLKYQLELKDDYIIRTNR---------------LIEDERKNKEKAVHLQE---------- 384
+ + Q E+++ +I+ +R + E+ +K ++ + HL+
Sbjct: 1737 VSQLQSEVEE--VIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 1794
Query: 385 ---------ELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMS 435
E +A+ K+++ + RV+ELE E+E+ + ++ K +VKE++
Sbjct: 1795 DLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELT 1854
Query: 436 DYSLLKEEKL---------ELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKEL 486
Y ++ K +L A+ K K+Q EE+ ++ L++ + Q EL
Sbjct: 1855 -YQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRK-------LQHEL 1906
Query: 487 RKAEKAIVVEHEEFESCR 504
+AE+ + + R
Sbjct: 1907 EEAEERADIAESQVNKLR 1924
Score = 38.9 bits (89), Expect = 0.025
Identities = 34/178 (19%), Positives = 85/178 (47%), Gaps = 18/178 (10%)
Query: 807 KSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHP 866
K + D++ K +E ++ N+ EM GL ++ + A+ ++Q
Sbjct: 954 KKDIDDLELTLAKVEKEKHATENKVKNLTE--EMAGLDET--IAKLSKEKKALQETHQQ- 1008
Query: 867 SVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESL 926
++D Q EE K + + + + E++ +L+ LE+E++ L + ++ +E L
Sbjct: 1009 TLDDLQAEEDKVNI------LTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL 1062
Query: 927 KIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQE 984
K+ + ++MEN+ + +++++ K N +I + +D+++ + +K ++E
Sbjct: 1063 KLAQESTMDMENDKQQLDEKLEKKEFEISN-------LISKIEDEQAVEIQLQKKIKE 1113
Score = 38.5 bits (88), Expect = 0.032
Identities = 126/684 (18%), Positives = 272/684 (39%), Gaps = 87/684 (12%)
Query: 378 KAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDY 437
K+ ++E+ + KEE ++ + + + E + + ++ + + + K+ + L +V+ +D
Sbjct: 844 KSAETEKEMATM---KEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADS 900
Query: 438 SLLKEEKLELLAQNKL--------LKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKA 489
EE+ E L +NK+ + ++ EE N L + + E + +K++
Sbjct: 901 LADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDL 960
Query: 490 EKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQT 549
E + +E + + K L +E+ + A++ K +++ Q D LQ ++
Sbjct: 961 ELTLAKVEKEKHATENKV-KNLTEEMAGLDETIAKLSKEKKALQETHQQTLD-DLQAEED 1018
Query: 550 QTALENEVYCNPKQSVID----RSVNGLINGNVVPCNGEISGDF---------LNNPFKQ 596
+ + + +Q V D + ++ ++ GD + N +Q
Sbjct: 1019 KVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQ 1078
Query: 597 ENVLARMVASRITNYPTAWVEGSSPDSDLE-FVANTKARVKELQQEAERLEKAFRSYHRR 655
+ I+N + + + + L+ + +AR++EL +E E E+A R+ +
Sbjct: 1079 LDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIE-AERASRAKAEK 1137
Query: 656 VIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVE 715
+S L+ + LE TS+ E + R Q LEE E
Sbjct: 1138 -----QRSDLSRELEEISERLEEAGGATSAQVE---LNKKREAEFQKLRRDLEEATLQHE 1189
Query: 716 ALTGSAASRLRGGTSSRRLSS--TPLPKAKRSLESE------------MYLEGLGRSHIA 761
A+ AA R + S L L + K+ LE E E + ++
Sbjct: 1190 AMV--AALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGN 1247
Query: 762 SPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKS-EFSDVDKLAFKD 820
C S +++ ++ Q+ R QTE + S + + D L +
Sbjct: 1248 LEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRA---RLQTEAGEYSRQLDEKDALVSQL 1304
Query: 821 NEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEE 880
+ ++S + + QLE + +A A A+ S + ++Q EE++E +
Sbjct: 1305 SRSKQASTQQIEELKHQLE-------EETKAKNALAHALQSSRHDCDLLREQYEEEQEGK 1357
Query: 881 KIREQ-------QVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKI--- 930
++ +V + R + E E LE +++L + QE + E++ K
Sbjct: 1358 AELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASL 1417
Query: 931 -KKELEMENELEMSNQEIKDKSA------HSENPLEKYMKIIQQEQDQ-----ESADKSS 978
K + ++NE+E +++ +A + +K + +Q+ ++ E++ K S
Sbjct: 1418 EKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKES 1477
Query: 979 KKMVQEGSLVDTL--QSSDKVESL 1000
+ + E V + +S D++E+L
Sbjct: 1478 RSLSTELFKVKNVYEESLDQLETL 1501
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 72.0 bits (175), Expect = 3e-12
Identities = 87/445 (19%), Positives = 198/445 (44%), Gaps = 41/445 (9%)
Query: 145 KELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYK 204
+EL E + E T N+ AE ++ D +L K +
Sbjct: 1145 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSV 1204
Query: 205 REIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEAL--VL 262
E+ EQ+ + K K K+ K+++ + ++ + +FEK C+ + L +
Sbjct: 1205 AELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIK 1264
Query: 263 REKSTLERIHKHQEIETKEIYAQ-----RQLLLKD---MDLLRGREAELKQRVEAFELNQ 314
++ +R+ + ++ + RQL KD L RG++A Q++E EL +
Sbjct: 1265 TKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQA-FTQQIE--ELKR 1321
Query: 315 KLQEE-KHKS-ITEALRRQEQNIKSFEETYDR-------------KLKNELLKYQLELKD 359
+L+EE K KS + AL+ + E Y+ K +E+ +++ + +
Sbjct: 1322 QLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYET 1381
Query: 360 DYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQS----VNRVKELELELESVKA 415
D I RT L E ++K ++ +E + A+NSK L ++ N V++L +++E A
Sbjct: 1382 DAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNA 1441
Query: 416 QSLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQP 475
+A+ K+ ++ + E K++ E A+ + +++ E ++ N +
Sbjct: 1442 ACIALDKKQRNFDKVLAEW------KQKYEETQAELEASQKESRSLSTELFKVKNAYEES 1495
Query: 476 APELAVFQKELRKAEKAIVVEHEEFESCRQALH--KQLQDEIEH-SAQLKAQILGYKASV 532
L ++E + ++ I E+ + +H ++++ +++H ++L+ + +AS+
Sbjct: 1496 LDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASL 1555
Query: 533 KSLTTQVADLKLQLKQTQTALENEV 557
+ ++ ++L+L Q ++ ++ ++
Sbjct: 1556 EHEEGKILRIQLELNQVKSEIDRKI 1580
Score = 68.2 bits (165), Expect = 4e-11
Identities = 179/899 (19%), Positives = 360/899 (40%), Gaps = 144/899 (16%)
Query: 200 LNEYKREIEEQ---LRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTM-FQND------- 248
L + K ++E+Q L + Q+ K D E AK K+E K +E TM +ND
Sbjct: 1024 LTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEK 1083
Query: 249 -----FEKA-CQAKSE---ALVLREKSTLERIHKHQEIETKEIYAQRQLLLKD----MDL 295
FE + Q K E AL ++ + ++ + E +EI A+R K DL
Sbjct: 1084 LKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDL 1143
Query: 296 LRGREAELKQRVEA--------FELNQKLQEE-------------KHKSITEALRRQE-Q 333
R E E+ +R+E E+N+K + E +H++ ALR++
Sbjct: 1144 SRELE-EISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHAD 1202
Query: 334 NIKSFEETYD--RKLKNELLKYQLELKDDY--IIRTNRLIEDERKNKEKAVH-LQEELIA 388
++ E D +++K +L K + ELK + + + + N EK L+++L
Sbjct: 1203 SVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSE 1262
Query: 389 INSKKEELNQSVNRVKELELELESVKAQ-SLAITKQNHMLNEKVKEMSDYSLLKEE-KLE 446
I +K+EE + +N + + L + + S + +++ M+++ + ++ EE K +
Sbjct: 1263 IKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQ 1322
Query: 447 LLAQNK-----------------LLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKA 489
L + K LL++Q EE + L +++ E+A ++ K
Sbjct: 1323 LEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRT---KY 1379
Query: 490 EKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVADLKLQLKQT 549
E + EE E ++ L ++LQD EH + ++ + + + L +V DL + ++++
Sbjct: 1380 ETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERS 1439
Query: 550 QTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRIT 609
A + + KQ D+ V + + + +R +++ +
Sbjct: 1440 NAAC---IALDKKQRNFDK----------VLAEWKQKYEETQAELEASQKESRSLSTELF 1486
Query: 610 NYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEK--AFRSYHRRVIKNSAKSPLAA 667
A+ E L+ + K K LQQE L + A H ++ K
Sbjct: 1487 KVKNAYEE------SLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHE 1540
Query: 668 KSPPSLHLLEAFKNITSSSPE--------RHIFGE-DRVVSEQPQVGTLEERND--VVEA 716
KS L EA ++ + + E DR ++E+ + +RN VVE+
Sbjct: 1541 KSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVES 1600
Query: 717 LTGSAASRLRGGTSSRRLSSTPLPKAKRSL-ESEMYLEGLGRSHIASPSPCPDRMPLPSP 775
+ + + +R + R+ K + L E E+ L R + + +
Sbjct: 1601 MQSTLDAEIRSRNDALRIKK----KMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKD 1656
Query: 776 TESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFE--SAGN 833
T+ +I EQ + RR +Q + EE +S E G
Sbjct: 1657 TQLHLDDAIRGQDDLKEQLAMVERRANLMQ-------------AEVEELRASLERTERGR 1703
Query: 834 MPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERR-- 891
+ E+ S + H + + Q Q E + ++ R + K ++
Sbjct: 1704 KMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAI 1763
Query: 892 ------QREERRQSNLQEVLERERRELEKLYQERKM-IEESLKIKI---KKELE-MENEL 940
E +++ + LER ++ +E+ ++ ++ ++E+ ++ + KK+++ +E +
Sbjct: 1764 TDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARV 1823
Query: 941 EMSNQEIKDKSAHSENP---LEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDK 996
E++ + H+ L K+ + +++ Q D+ K +++ LVD LQ+ K
Sbjct: 1824 RELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDR--KNILRLQDLVDKLQTKVK 1880
Score = 59.3 bits (142), Expect = 2e-08
Identities = 153/797 (19%), Positives = 316/797 (39%), Gaps = 116/797 (14%)
Query: 239 EKELTMFQNDFEKACQ--AKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLL 296
EKE+ + +FEK + AK+EA K +E+E K + L+ + DL
Sbjct: 850 EKEMANMKEEFEKTKEELAKTEA-------------KRKELEEKMV----TLMQEKNDLQ 892
Query: 297 RGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLE 356
+AE +A EE+ + + + E IK E +R E + +L
Sbjct: 893 LQVQAEADALADA--------EERCDQLIKTKIQLEAKIK---EVTERAEDEEEINAELT 941
Query: 357 LKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQ 416
K R +EDE +K + E +A K++ + N+VK L E+ +
Sbjct: 942 AK-------KRKLEDECSELKKDIDDLELTLAKVEKEKHATE--NKVKNLTEEMAGLDET 992
Query: 417 SLAITKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKL-LKQQ---LEESRNENLRLLNRL 472
+TK+ L E ++ D ++E+K+ L + K L+QQ LE S + +L L
Sbjct: 993 IAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDL 1052
Query: 473 AQPAPELAVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASV 532
+ +L + +L+ A+++ + + E+ +Q L+++L+ + + L+ +I +A
Sbjct: 1053 ERAKRKL---EGDLKLAQESTM----DTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALA 1105
Query: 533 KSLTTQVADLKLQLKQTQTALENE----VYCNPKQSVIDRSVNGLINGNVVPCNGEISGD 588
L ++ +L+ ++++ + +E E ++S + R + I+ + G S
Sbjct: 1106 IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE-ISERLEEAGGATSAQ 1164
Query: 589 FLNNPFKQ---ENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERL 645
N ++ + + + S + + TA + + VA ++ LQ+ ++L
Sbjct: 1165 IEMNKKREAEFQKMRRDLEESTLQHEATA---AALRKKHADSVAELGEQIDSLQRVKQKL 1221
Query: 646 EKAFRSYHRRVIKNSAKSPLAAKSPPSLH-----LLEAFKNITSSSPERHIFGEDRVVSE 700
EK + ++ +K+ + L + I + E + R+++E
Sbjct: 1222 EKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEE-----QQRLINE 1276
Query: 701 --------QPQVGTLEERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYL 752
+ G + D +A+ S+L G ++ + + + KR LE E
Sbjct: 1277 LSAQKARLHTESGEFSRQLDEKDAM----VSQLSRG---KQAFTQQIEELKRQLEEETKA 1329
Query: 753 EGLGRSHIASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTE---LQDKSE 809
+ + S D + E + S +V +R + E +Q E
Sbjct: 1330 KSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEE 1389
Query: 810 FSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHV-----DAAAAAVPLSYQ 864
+ K + ++ E E+ + LE ++ + + AA + L +
Sbjct: 1390 LEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKK 1449
Query: 865 HPSVDQKQIE-EQKEEEKIREQQVKERRQRE-ERRQSNLQEVLERERRELEKLYQERKMI 922
+ D+ E +QK EE E + ++ R ++ E LE L +E K +
Sbjct: 1450 QRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNL 1509
Query: 923 EESLK----------------IKIKKELEME-NELEMSNQEIKDKSAHSENP---LEKYM 962
++ + K+KK+L+ E +EL+ S +E + H E ++ +
Sbjct: 1510 QQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLEL 1569
Query: 963 KIIQQEQDQESADKSSK 979
++ E D++ A+K +
Sbjct: 1570 NQVKSEIDRKIAEKDEE 1586
Score = 54.7 bits (130), Expect = 4e-07
Identities = 79/402 (19%), Positives = 171/402 (42%), Gaps = 81/402 (20%)
Query: 192 KFESLEIKLNEYKREIE----------EQLRAEMCQKLKFFKDTEIAKIK-----MEAKK 236
K ++++LN+ K EI+ +QL+ + ++ + T A+I+ + KK
Sbjct: 1561 KILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKK 1620
Query: 237 KYEKELTMFQNDFEKACQAKSEALV-LREKSTL---ERIHKHQEIETKE-IYAQRQLLLK 291
K E +L + A + +EAL LR + ++H I ++ + Q ++ +
Sbjct: 1621 KMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVER 1680
Query: 292 DMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELL 351
+L++ EL+ +E E +K+ E++ +E ++ S T +KL+ ++
Sbjct: 1681 RANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINT-KKKLETDIS 1739
Query: 352 KYQLELKDDYIIRTNR---------------LIEDERKNKEKAVHLQE------------ 384
+ Q E++D I++ R + E+ +K ++ + HL+
Sbjct: 1740 QIQGEMED--IVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDL 1797
Query: 385 -------ELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDY 437
E +A+ K+++ + RV+ELE E+ES + ++ K +VKE
Sbjct: 1798 QLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKE---- 1853
Query: 438 SLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEH 497
L Q EE R LRL + + + ++ ++++ +AE+ V
Sbjct: 1854 ----------------LTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNL 1897
Query: 498 EEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQV 539
+F + L +L++ E + ++Q+ + + + T+V
Sbjct: 1898 AKF----RKLQHELEEAKERADIAESQVNKLRVKSREVHTKV 1935
Score = 40.8 bits (94), Expect = 0.007
Identities = 39/192 (20%), Positives = 88/192 (45%), Gaps = 17/192 (8%)
Query: 807 KSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHP 866
K + D++ K +E ++ N+ EM GL ++ + A+ ++Q
Sbjct: 955 KKDIDDLELTLAKVEKEKHATENKVKNLTE--EMAGLDET--IAKLTKEKKALQEAHQQ- 1009
Query: 867 SVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESL 926
++D Q+EE K + + + + E++ +L+ LE+E++ L + ++ +E L
Sbjct: 1010 TLDDLQMEEDKVNT------LTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDL 1063
Query: 927 KIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGS 986
K+ + ++ EN+ + N+++K K N K E +Q A + KK+ + +
Sbjct: 1064 KLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKI------EDEQALAIQLQKKIKELQA 1117
Query: 987 LVDTLQSSDKVE 998
++ L+ + E
Sbjct: 1118 RIEELEEEIEAE 1129
Score = 36.2 bits (82), Expect = 0.16
Identities = 27/117 (23%), Positives = 58/117 (49%), Gaps = 17/117 (14%)
Query: 895 ERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHS 954
E+ +N++E E+ + EL K +RK +EE K+ ++ +N+L++ Q D A +
Sbjct: 850 EKEMANMKEEFEKTKEELAKTEAKRKELEE----KMVTLMQEKNDLQLQVQAEADALADA 905
Query: 955 ENPLEKYMK-----------IIQQEQDQE--SADKSSKKMVQEGSLVDTLQSSDKVE 998
E ++ +K + ++ +D+E +A+ ++KK E + + D +E
Sbjct: 906 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 962
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 71.6 bits (174), Expect = 3e-12
Identities = 174/898 (19%), Positives = 351/898 (39%), Gaps = 117/898 (13%)
Query: 152 QAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADA-------YPQRIKFESLEIKLNEYK 204
+AK ET S T ++ LA +LQ D ADA +++ E +L+E +
Sbjct: 916 EAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSE-R 974
Query: 205 REIEEQLRAEMCQKLKFFKD--TEIAKIKMEAK---KKYEKELTMFQNDF-----EKACQ 254
E EE++ A++ + + +D TE+ K + K K EKE +N E A
Sbjct: 975 LEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAAL 1034
Query: 255 AKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQ 314
+S A + +EK L+ H ++ Q + L + L+Q+VE E +
Sbjct: 1035 DESVARLTKEKKALQEAH-------QQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSL 1087
Query: 315 KLQEEKHKSITEALRRQEQNIKSFEETY-DRKLKNELLKYQLELKDDYIIRTNRLIEDER 373
+ +++ A R+ E ++K +E+ D + L+ +L+ KD + + + +EDE+
Sbjct: 1088 EQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQ 1147
Query: 374 KNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKE 433
+Q+++ + ++ EEL + + + +E +A++ ++ L+E+++E
Sbjct: 1148 L---LGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEA---ARELEELSERLEE 1201
Query: 434 MSDYSLLKEEKL-ELLAQNKLLKQQLEES-----------RNENLRLLNRLAQPAPELAV 481
S + E + A+ L+++LEE+ R + L + L
Sbjct: 1202 AGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQR 1261
Query: 482 FQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVAD 541
+++L K + + +E ++ + + L + + + Q+ K V+ L Q+AD
Sbjct: 1262 VRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLAD 1321
Query: 542 LKLQLKQTQT-ALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVL 600
Q + QT + E K+ +I + L G + S + L ++E+
Sbjct: 1322 ASTQRGRLQTESGELSRLLEEKECLISQ----LSRGKALAAQ---SLEELRRQLEEESKA 1374
Query: 601 ARMVASRITNYPTAWVEGSSPDSDL-----EFVANTKARVKELQQEAERLEKAFRSYHRR 655
+A V+ D DL E A +A ++ L +A +RS +
Sbjct: 1375 KSALAHA--------VQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEA 1426
Query: 656 VIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIF--GEDRVVSEQPQVGTLEERNDV 713
+ AK +L L EA + + +++ + + R+ +E V ER
Sbjct: 1427 DAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATS 1486
Query: 714 VEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLP 773
A L RR + + + + E GLG
Sbjct: 1487 AAAALDKKQRHLERALEERRRQEEEMQRELEAAQRES--RGLGTELFR------------ 1532
Query: 774 SPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDK-SEFSDVDKLAFKDNEEFESSFESAG 832
H ++ + + L R LQ++ S+ +D L+ K +E E + ++
Sbjct: 1533 --LRHGHEEALEALET-------LKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALE 1583
Query: 833 NMPRQLEMGGLSPAG--DMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKER 890
+++ G ++ + LS VD+K E ++++
Sbjct: 1584 GEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAE--------KDEECANL 1635
Query: 891 RQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDK 950
R+ +R +LQ L+ E R E+L++K K E ++ N+LE+
Sbjct: 1636 RRNHQRAVESLQASLDAETRAR----------NEALRLKKKMEGDL-NDLELQ----LGH 1680
Query: 951 SAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEEL 1008
+ + +++Q + +E A + ++ + L + Q+ ++ SL EEL
Sbjct: 1681 ATRQATEAQAATRLMQAQLKEEQAGRDEEQRL-AAELHEQAQALERRASLLAAELEEL 1737
Score = 50.8 bits (120), Expect = 6e-06
Identities = 99/460 (21%), Positives = 184/460 (40%), Gaps = 75/460 (16%)
Query: 145 KELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYK 204
+EL E +A+ + + L E + +++ + QR E +L +
Sbjct: 1165 EELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLR 1224
Query: 205 REIEE-QLRAEMCQKLKFFKDTE-----------IAKIKMEAKKKYEKELTMFQNDFEKA 252
RE+EE LR E K E + +++ + +K+ + EL M +D
Sbjct: 1225 RELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKE-KSELRMEVDDLAAN 1283
Query: 253 CQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGR----EAELKQRVE 308
+ + A EK L R ++ Q E K + Q L D RGR EL + +E
Sbjct: 1284 VETLTRAKASAEK--LCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLE 1341
Query: 309 -------------------AFELNQKLQEE-KHKS----ITEALRR-----QEQNIKSFE 339
EL ++L+EE K KS +ALR +EQ+ + E
Sbjct: 1342 EKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAE 1401
Query: 340 ETYD-----RKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKE 394
+ K E+ +++ + + D I RT L E ++K + +E + A N+K
Sbjct: 1402 AQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCS 1461
Query: 395 ELNQSVNRV----KELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKLE---- 446
L ++ R+ +++ LELE + + A+ K+ L ++E + +LE
Sbjct: 1462 SLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQR 1521
Query: 447 -----------LLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQK---ELRKAEKA 492
L ++ + LE + EN L ++ ++++ K EL K +KA
Sbjct: 1522 ESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKA 1581
Query: 493 IVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASV 532
+ E E ++ + L+ E + +++ ++ KA V
Sbjct: 1582 LEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEV 1621
Score = 50.4 bits (119), Expect = 8e-06
Identities = 106/508 (20%), Positives = 198/508 (38%), Gaps = 81/508 (15%)
Query: 107 TMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSST 166
T +D L KI L + L +D Q+G L EL+ + KE +
Sbjct: 1300 TYEDQLSEAKIK-VEELQRQL---ADASTQRGRLQTESGELSRLLEEKECLISQLSRGKA 1355
Query: 167 FNRDSLAEKLQLIDDQFA--DAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKD 224
SL E + ++++ A ++ + L + E E + +AE+ Q+L +
Sbjct: 1356 LAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAEL-QRLLSKAN 1414
Query: 225 TEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREK-----------STLERIHK 273
E+A + + KYE + + E+A K AL L+E S+LE+
Sbjct: 1415 AEVA----QWRSKYEADAIQRTEELEEA--KKKLALRLQEAEEGVEAANAKCSSLEKAKL 1468
Query: 274 HQEIETKEIYAQRQ--------LLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSIT 325
+ E++++ + + L K L R E +Q E + Q E T
Sbjct: 1469 RLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGT 1528
Query: 326 EALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEE 385
E R + + ++ E K +N+ L+ ++ D + + + I++ K K+ + E
Sbjct: 1529 ELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSE 1588
Query: 386 L-IAINSKKEELNQSVNRVKELELELESVKA----------QSLAITKQNHM-------- 426
+ A+ + L + ++LEL VKA + A ++NH
Sbjct: 1589 IQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQA 1648
Query: 427 --------------LNEKVK-EMSDYSL----LKEEKLELLAQNKLLKQQLEE---SRNE 464
L +K++ +++D L + E A +L++ QL+E R+E
Sbjct: 1649 SLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDE 1708
Query: 465 NLRLLNRLAQPAPEL----AVFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQ 520
RL L + A L ++ EL + A+ E+ E R+ ++L + E
Sbjct: 1709 EQRLAAELHEQAQALERRASLLAAELEELRAAL----EQGERSRRLAEQELLEATERLNL 1764
Query: 521 LKAQILGYKASVKSLTTQVADLKLQLKQ 548
L +Q G K L +A L ++++
Sbjct: 1765 LHSQNTGLLNQKKKLEADLAQLSGEVEE 1792
Score = 43.9 bits (102), Expect = 8e-04
Identities = 75/357 (21%), Positives = 148/357 (41%), Gaps = 70/357 (19%)
Query: 196 LEIKLNEYKREIEEQL--RAEMCQKLK-------------FFKDTEIAKIKMEAKKKYEK 240
++++L++ K E++ +L + E C L+ +T + KKK E
Sbjct: 1610 IQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEG 1669
Query: 241 ELTMFQNDFE--------KACQAKSEALVLREKSTLERIHKHQEIE-TKEIYAQRQLLLK 291
+L ND E +A +A++ +++ + E+ + +E E++ Q Q L +
Sbjct: 1670 DL----NDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALER 1725
Query: 292 DMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRR-QEQNIKSFEETYDRKLKNEL 350
LL EL+ +E E +++L E++ TE L QN + +KL+ +L
Sbjct: 1726 RASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQK--KKLEADL 1783
Query: 351 LKYQLELKD-------------DYIIRTNRLIEDERKNKEKAVHLQE------------- 384
+ E+++ I + E+ +K ++ + HL+
Sbjct: 1784 AQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQ 1843
Query: 385 ------ELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYS 438
E A+ K+++ + +V+ELE EL++ + + K +VKE++ +
Sbjct: 1844 ARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQA 1903
Query: 439 LLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPA-PELAVFQK---ELRKAEK 491
EE + LA+ + L +L+ R Q A LA ++K EL AE+
Sbjct: 1904 ---EEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEE 1957
Score = 37.4 bits (85), Expect = 0.072
Identities = 33/127 (25%), Positives = 61/127 (48%), Gaps = 19/127 (14%)
Query: 873 IEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERR----------ELEKLYQERKMI 922
+E+ + ++ EQ++ E +R S +L ++++ E+E+ QER+
Sbjct: 1741 LEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREA 1800
Query: 923 EESLKIKIKKELEMENELEMSNQEIKDKSAHSE---NPLEKYMKIIQQ--EQDQESADKS 977
EE K I M EL+ +D SAH E LE+ ++ +Q E+ +++A +
Sbjct: 1801 EEKAKKAITDAAMMAEELKKE----QDTSAHLERMKKTLEQTVRELQARLEEAEQAALRG 1856
Query: 978 SKKMVQE 984
KK VQ+
Sbjct: 1857 GKKQVQK 1863
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 71.2 bits (173), Expect = 4e-12
Identities = 182/963 (18%), Positives = 395/963 (41%), Gaps = 103/963 (10%)
Query: 119 PTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDS-----LA 173
P S++ ++L SG +++GF + E++ + C+ E S R L
Sbjct: 79 PESTIMRTLHSGEITSHEQGFSVELESEIST---TADDCSSEVNGCSFVMRTGKPTNLLR 135
Query: 174 EKLQLIDDQFAD--AYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIK 231
E+ +DD +++ A E +E +L + EIEE L E+ ++++ TE +
Sbjct: 136 EEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEE-LNREL-EEMRVTYGTEGLQQL 193
Query: 232 ME---AKKKYEKELTMFQNDFEKACQAKSEA----LVLREKSTLERIHKHQEIETKEIYA 284
E A K+ + +T + ++A + K E L L E+S +I + Q+++ E
Sbjct: 194 QEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQI-QFQQLQASETLR 252
Query: 285 QRQLLLKDMDLLRGREAELKQRVEAFELNQKLQE--EKHKSITEALRRQEQNIKSFEETY 342
DLL+ ++ L + + E + L++ +K + T + ++ IK +E
Sbjct: 253 NSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQ 312
Query: 343 DRKLKNELLKYQLELKDDYIIRTN-RLIEDERKNKEKAVHLQEELIAINSKKEELNQSVN 401
D+K++N K +++ K+ I N ++IE+E+K E L + +E++ Q
Sbjct: 313 DKKVENSN-KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQ 371
Query: 402 RVKELELELESVKAQSLAITKQNHMLNEKVKEM-------SDYSLLKEEKLELLAQNKL- 453
+K ++LEL + K + +++ L V+E+ S + +++E Q KL
Sbjct: 372 EIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLE 431
Query: 454 -LKQQLEESRNENL------RLLNRLAQPAPELAVFQKELRKAEKA---IVVEHEEFESC 503
L+ +L+E + + + +AQ + E+ A ++ I V ++ +
Sbjct: 432 QLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLM 491
Query: 504 RQALHK---QLQDEIEHSAQLKAQ---ILGYKASV-KSLTTQVADLKLQLKQTQTALENE 556
A+++ +LQD +LK + IL K ++ + L V +L +Q Q A +
Sbjct: 492 NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTI 551
Query: 557 VYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWV 616
K + +S++ + + + S L + E ++ + A +
Sbjct: 552 AEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVL 611
Query: 617 EGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHL- 675
+ + + E + ++E +L++ HR I+ K +H
Sbjct: 612 DRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEK-------LKDNLGIHYK 664
Query: 676 --LEAFKNITSSSPERHIFGEDRVVSEQPQ-VGTLEERNDVVEALTGSAASRL------- 725
++ +N S E F +D ++++Q Q + + + D+ ++L S + +
Sbjct: 665 QQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINEL 724
Query: 726 ------------RGGTSSR-----RLSSTPLPKAKRSLESEM-----YLEGLGRSHIASP 763
GT + +L + L K + E+++ LE
Sbjct: 725 QKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEK 784
Query: 764 SPCPDRMPLPSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEE 823
D + + +P L I S + K ++ ++ E+ + E D+ + + NEE
Sbjct: 785 KTLEDMLKIHTPVSQEERL-IFLDSIKSKSKDSVWEKEIEILIE-ENEDLKQQCIQLNEE 842
Query: 824 FESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQ----IEEQKEE 879
E + + E+ + + + + S ++ K + E+
Sbjct: 843 IEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHL 902
Query: 880 EKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENE 939
++I VK + + ++ + E LE E + ++ + E L++ +++LE+
Sbjct: 903 QRINPTTVKMKSSVFDEDKTFVAETLEMG----EVVEKDTTELMEKLEVTKREKLELSQR 958
Query: 940 LEMSNQEIKDKSAHSE-NPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSD-KV 997
L ++++K K H E + L + +K ++QE++Q S +++ + + +QS D +V
Sbjct: 959 LSDLSEQLKQK--HGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQV 1016
Query: 998 ESL 1000
SL
Sbjct: 1017 SSL 1019
Score = 68.6 bits (166), Expect = 3e-11
Identities = 103/429 (24%), Positives = 191/429 (44%), Gaps = 90/429 (20%)
Query: 109 QDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFN 168
+D ++L+ + K + S KE K L L+E + E E +F+
Sbjct: 485 EDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEEL----SFS 540
Query: 169 RDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIE--EQLRAEMCQKLKFFKDTE 226
R+ + Q I +Q E KLNE + + E L+AE+ + K+ E
Sbjct: 541 REQIQRARQTIAEQ--------------ESKLNEAHKSLSTVEDLKAEIVSASESRKELE 586
Query: 227 IAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQR 286
+ K+E E+T ++ K E L + + L+R+ + QE E + + Q
Sbjct: 587 L---------KHEAEVTNYK--------IKLEMLEKEKNAVLDRMAESQEAELERLRTQ- 628
Query: 287 QLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKL 346
LL E EL + E E+ ++ EK K +Q I + +K+
Sbjct: 629 --------LLFSHEEELSKLKEDLEIEHRINIEKLKDNLGI--HYKQQIDGLQNEMSQKI 678
Query: 347 KNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKE- 405
E ++++ KD+ I + N+LI + K K+ LQ+ L+ NSK EE+ +N +++
Sbjct: 679 --ETMQFE---KDNLITKQNQLILEISKLKD----LQQSLV--NSKSEEMTLQINELQKE 727
Query: 406 -------------LELELESVKAQSLAITKQ----NHMLNEKVKEM-SDYSLLKEEKLEL 447
LE E++ ++ ++ + KQ + L EK ++ ++ S+LK+EK L
Sbjct: 728 IEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTL 787
Query: 448 LAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFESCRQAL 507
+LK S+ E L L+ + + + +V++KE+ + ++ E+E+ + +Q +
Sbjct: 788 ---EDMLKIHTPVSQEERLIFLDSIKSKSKD-SVWEKEI----EILIEENEDLK--QQCI 837
Query: 508 HKQLQDEIE 516
QL +EIE
Sbjct: 838 --QLNEEIE 844
Score = 61.6 bits (148), Expect = 4e-09
Identities = 146/672 (21%), Positives = 265/672 (39%), Gaps = 122/672 (18%)
Query: 102 KEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMET 161
K K+ + + L L +INPT+ KS V DK F+ L E+ E + + ME
Sbjct: 890 KSKLKALNEELHLQRINPTTVKMKSSVFDEDKT----FVAETL-EMGEVVEKDTTELMEK 944
Query: 162 QTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKF 221
+ + L+++L + +Q + + I F + E+K + ++E + LR C++L+
Sbjct: 945 LEVTKREKLELSQRLSDLSEQLKQKHGE-ISFLNEEVKSLKQEKE-QVSLR---CRELEI 999
Query: 222 F----KDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEI 277
+ + + + +TM E + +++ K +E + +
Sbjct: 1000 IINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENM 1059
Query: 278 ETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKS 337
E Q QL+L D L E R N KLQ+E + + + EQN
Sbjct: 1060 TVGEESKQEQLIL---DHLPSVTKESSLRATQPSENDKLQKELN------VLKSEQN--- 1107
Query: 338 FEETYDRKLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAV-HLQEELIAINSKKEEL 396
D +L+ E + L L Y +++ E K+KA+ L+EELI +K +
Sbjct: 1108 -----DLRLQMEAQRICLSLV--YSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKE 1160
Query: 397 NQSVNRVKELELELESVKAQSLAIT-KQNHMLNEK----VKEMSDYSLL----------- 440
Q ++ +LEL+++K Q K H+L K V E Y L
Sbjct: 1161 LQKIH-----QLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYT 1215
Query: 441 -----------KEEKLELLAQNKLLKQQLEESR------NENLR-LLNRLAQPAPELAVF 482
KE + +++N+ +L++ R EN+ LLN++ + +L V
Sbjct: 1216 PALKCEVNAEDKENSGDYISENE--DPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVL 1273
Query: 483 QKELRK-------------AEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKA----QI 525
Q L K E+ + E EF S + ++ H ++L + +
Sbjct: 1274 QTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEK 1333
Query: 526 LGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEI 585
+ V+ L + ++ L+ QLK+T+ E E++C + + + + V P
Sbjct: 1334 TKLEEQVQELESLISSLQQQLKETEQNYEAEIHC------LQKRLQAVSESTVPP----- 1382
Query: 586 SGDFLNNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERL 645
++V+ ++ T YP + V+ + D +EF + + VKE + L
Sbjct: 1383 -------SLPVDSVVITESDAQRTMYPGSCVK-KNIDGTIEF--SGEFGVKEETNIVKLL 1432
Query: 646 EKAFR-SYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSS--------PERHIFGEDR 696
EK ++ V K +A L + K T+SS E+H F E +
Sbjct: 1433 EKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMK 1492
Query: 697 VVSEQPQVGTLE 708
+ +Q T E
Sbjct: 1493 LSQDQIGFQTFE 1504
Score = 55.1 bits (131), Expect = 3e-07
Identities = 136/626 (21%), Positives = 256/626 (40%), Gaps = 143/626 (22%)
Query: 145 KELAEYH-QAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEY 203
+EL EY+ Q K+S +E Q + +D E + +Q + +++ L+ +L +
Sbjct: 3119 QELLEYNIQQKQSQMLEMQVELSSMKDRATE----LQEQLSS---EKMVVAELKSELAQT 3171
Query: 204 KREIEEQLRAEMCQKLKFFKDTEIAKIKMEAK--------------KKYEKELTMFQNDF 249
K E+E L+A+ K K+ E +++++ K +K +EL + +
Sbjct: 3172 KLELETTLKAQH----KHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSREL-QWALEK 3226
Query: 250 EKACQAKSEALVLREKSTLERI------HKHQEIET---------------KEIYAQRQL 288
EKA +SE R+K LE + K + ++ ++I +QR L
Sbjct: 3227 EKAKLGRSEE---RDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRML 3283
Query: 289 LLKDMDLLRGREAELK-----QRVEAFELNQKLQEEK--HKSI--------------TEA 327
+ +GR EL+ ++V E++ L E+ H + +E
Sbjct: 3284 YDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSED 3343
Query: 328 LRRQEQNIKSFEETYDR--KLKNELLKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEE 385
L ++ Q K EE + R +L NE KY+L+ ++T + +E +R+ K + ++E
Sbjct: 3344 LLKELQ--KQLEEKHSRIVELLNETEKYKLDS-----LQTRQQMEKDRQVHRKTLQTEQE 3396
Query: 386 LIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKEEKL 445
KK +++ ++V++L+ +LE + Q + + L ++E L +EEK
Sbjct: 3397 ANTEGQKK--MHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKR 3454
Query: 446 ELLAQNKLLKQQLEESRNENL---RLLNRLAQPAPELAVFQKELRKAEKAIVVE------ 496
E ++L Q L E +L R N + Q + E +++ A ++E
Sbjct: 3455 E---SRRILYQNLNEPTTWSLTSDRTRNWVLQQK-----IEGETKESNYAKLIEMNGGGT 3506
Query: 497 --HEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKS------------LTTQVADL 542
+ E E RQ L K Q+L KAS + + + ++
Sbjct: 3507 GCNHELEMIRQKL---------QCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEI 3557
Query: 543 KLQLKQTQTALENEVYCNPKQSVIDRSVN-GLINGNVVPCNGEISGDFLNNPFKQENVLA 601
LQL Q T + E + S++ S + G + ++ N E++G ++ +++N L
Sbjct: 3558 ILQL-QKLTGQQGE-----EPSLVSPSTSCGSLTERLLRQNAELTG-HISQLTEEKNDLR 3610
Query: 602 RMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKEL--------QQEAERLEKAFRSYH 653
MV G+ D+ F N A ++ + +E L+K+ +
Sbjct: 3611 NMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAE 3670
Query: 654 RRVIKNSAK----SPLAAKSPPSLHL 675
V K A+ S L SP S H+
Sbjct: 3671 AEVYKLKAELRNDSLLQTLSPDSEHV 3696
Score = 47.8 bits (112), Expect = 5e-05
Identities = 100/435 (22%), Positives = 191/435 (43%), Gaps = 74/435 (17%)
Query: 159 METQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRA--EMC 216
+E Q + RD L ++++ ++ D Q +F LE + N ++ +Q +A +
Sbjct: 2006 LEVQCQAEKVRDDLQKQVKALE---IDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQL 2062
Query: 217 QKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQE 276
+K++ F D E E E +FQ + +K Q L+ + I +HQ
Sbjct: 2063 EKMRKFLD--------EQAIDREHERDVFQQEIQKLEQQ------LKVVPRFQPISEHQT 2108
Query: 277 IETKEIYAQ-RQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITEALRRQEQNI 335
E +++ ++ K +LL +E + E E +KL E + + + +AL +
Sbjct: 2109 REVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKL-EFRVRELEQALL---VSA 2164
Query: 336 KSFEETYDRK------LKNEL-LKYQLELKDDYIIRTNRLIEDERKNKEKAVHLQEELIA 388
+F++ DRK K EL L+ QL+ + D I +RK KE +L+E+L
Sbjct: 2165 DTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAI---------DRKEKE-ITNLEEQL-- 2212
Query: 389 INSKKEELNQSVNRVKELELELESVKAQSLA----ITKQNHMLNEKVKEM---------- 434
+EEL V++L ++LE K +S + ++N + + ++++
Sbjct: 2213 -EQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAM 2271
Query: 435 --SDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLL-----NRLAQPAPELAVFQKELR 487
D +L + +++ + ++ QL E + + L N++ + EL ++L
Sbjct: 2272 STQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELI---RDLE 2328
Query: 488 KAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVK--SLTTQVADLKLQ 545
+ ++ + E + R+ +QL + IE Q A I G K S+ SL+ + LK Q
Sbjct: 2329 TQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANI-GQKTSMNAHSLSEEADSLKHQ 2387
Query: 546 LK---QTQTALENEV 557
L + ALE +V
Sbjct: 2388 LDVVIAEKLALEQQV 2402
Score = 47.0 bits (110), Expect = 9e-05
Identities = 150/797 (18%), Positives = 301/797 (37%), Gaps = 147/797 (18%)
Query: 237 KYEKELTMFQNDFEKACQAK------SEALVLREKSTLERIHKHQEIETKEIYAQRQLLL 290
++ KE+ + +D ++K SE + ++K+ + R H EI + A RQL+L
Sbjct: 1523 EHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLML 1582
Query: 291 KD-------MDLLRG-----------REAELKQRVEAFELNQKLQEEKHKSITEALRRQE 332
+ +L+R R+A ++Q E ++LQEE + + +R
Sbjct: 1583 NEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSS 1642
Query: 333 QNIKSFEETYDRKLKNELL-----------KYQLELKDDYII----RTNRLIEDERKNKE 377
+ ++ +R L EL K EL++ N+ +E+ KE
Sbjct: 1643 IDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKE 1702
Query: 378 KAVHLQEELIA---INSKKEELNQSVNRVKELELELESVKAQSLAITKQNHML---NEKV 431
K + + E + +++++ L ++ NR+ ++ LE+ A ++ T H+L +
Sbjct: 1703 KELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTA-AVEETIGRHVLGILDRSS 1761
Query: 432 KEMSDYSLLKEEKLELLAQNKLLKQQLE------------ESRNENLRLLNRLAQPAPEL 479
K S SL+ + E ++ + ++ + ++ + +++ + EL
Sbjct: 1762 KSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTEL 1821
Query: 480 AVFQKELRKAEKAIVVEHEEF-----ESCRQALHKQLQDEIEHSAQLK----AQILGYKA 530
+ A I E+EE + A+ K L+ E S+QL+ Q +
Sbjct: 1822 SQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRE 1881
Query: 531 SVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFL 590
S + LK Q ++ + L E + +V G+I+G
Sbjct: 1882 SFRQKQEATESLKCQ-EELRERLHEESRAREQLAVELSKAEGVIDGYA------------ 1928
Query: 591 NNPFKQENVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFR 650
++ + R + + + +L +N R++EL+ E +++++
Sbjct: 1929 ----DEKTLFERQIQEKTDIIDRL-------EQELLCASN---RLQELEAEQQQIQE--- 1971
Query: 651 SYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEER 710
R ++ ++ A P LL+ + + E E Q QV LE
Sbjct: 1972 --ERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEI- 2028
Query: 711 NDVVEALTGSAASRLRGGTS--SRRLSSTPLPKAKRSLESEMYLEGLGRSH--------I 760
DV E ++ T R + L K + + + + R H I
Sbjct: 2029 -DVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEI 2087
Query: 761 ASPSPCPDRMPLPSPTESRHSLSIPPVSSPPEQK--------VGLYRRQTELQDKSEFSD 812
+P P + + +++ ++K + + Q ++Q+++E +
Sbjct: 2088 QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNE--E 2145
Query: 813 VDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQ 872
++KL F+ E ++ SA + D H A A LS +
Sbjct: 2146 IEKLEFRVRELEQALLVSADTFQK---------VEDRKHFGAVEAKPELSLE-------- 2188
Query: 873 IEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKK 932
++ Q E + I R+E+ +NL+E LE+ R ELE +E + + L+I+ K+
Sbjct: 2189 VQLQAERDAI---------DRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKE 2239
Query: 933 ELEMENELEMSNQEIKD 949
ELE N+ KD
Sbjct: 2240 STTRLQELEQENKLFKD 2256
Score = 44.7 bits (104), Expect = 5e-04
Identities = 182/993 (18%), Positives = 375/993 (37%), Gaps = 160/993 (16%)
Query: 102 KEKVFTMQDL----LQLIKINPTSSLYKSL------VSGSDKENQKGFLMHFLKELAEYH 151
+EK+ +Q + LQ +K T K L + + E FL L EY+
Sbjct: 1155 EEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYY 1214
Query: 152 QAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKF--ESLEIKLNEYKREIEE 209
C + + ++++ + + +D Y ++ E++ LN+ E +
Sbjct: 1215 TPALKCEVNAE-----DKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNK 1269
Query: 210 QLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQN---------DFEKACQAKSEAL 260
L + + + T+ K++ ++ KE T F + D + ++K +L
Sbjct: 1270 LLVLQTRLSKIWGQQTDGMKLEF-GEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSL 1328
Query: 261 VLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEK 320
EK+ LE + QE+E+ Q+QL +E E E L ++LQ
Sbjct: 1329 QDLEKTKLEE--QVQELESLISSLQQQL----------KETEQNYEAEIHCLQKRLQAVS 1376
Query: 321 HKSITEALRRQEQNIKSFEET---YDRKLKNELLKYQLELKDDYIIR--TNRLIEDERKN 375
++ +L I + Y + + +E ++ ++ TN + E++
Sbjct: 1377 ESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQY 1436
Query: 376 KEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMS 435
+E+ L+EE+ K ++ S+ ++ EL S ++ A +KQ H + ++ +
Sbjct: 1437 QEQ---LEEEVA-----KVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYF 1488
Query: 436 DYSLLKEEKL----------ELLAQNKLLKQQLEESRNENLRLLNRLAQPAPE-----LA 480
+ L ++++ + + K L ++L E E L L N PE L
Sbjct: 1489 NEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEIL-LSNSDPHDIPESKDCVLT 1547
Query: 481 VFQKELRK--------------------AEKAIVVEHEEFESCRQALHKQLQDEIEHSAQ 520
+ ++ K A + +++ E+ E RQ L +Q Q+ + +
Sbjct: 1548 ISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATEL 1607
Query: 521 LKA----QILGYKASVKSLTTQVADLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLING 576
L+ Q+ + + L ++ L QL Q +++++NE + ++ V+ + L
Sbjct: 1608 LRQAHMRQMERQREDQEQLQEEIKRLNRQLAQ-RSSIDNENLVSERERVLLEELEAL--- 1663
Query: 577 NVVPCNGEISGDFLNNPFKQENVLAR-MVASRITNYPTAWVEGSSPDSDLEFVANTKARV 635
KQ ++ R + + N T G+ ++E +
Sbjct: 1664 ------------------KQLSLAGREKLCCELRNSSTQTQNGNENQGEVE---EQTFKE 1702
Query: 636 KELQQEAERLEKAFRSYHRRVIKNSAKSPLAAKSPPSLHLLEAFKNITSSSPE--RHIFG 693
KEL ++ E + S R ++ + L LLE K + RH+ G
Sbjct: 1703 KELDRKPEDVPPEILSNERYALQKANNRLLKI-------LLEVVKTTAAVEETIGRHVLG 1755
Query: 694 E-DRVVSEQPQVGTL--EERNDVVEALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEM 750
DR Q + E V++ +R+ S S + +P+ ++ S++
Sbjct: 1756 ILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTD-ESIPSYSGSDMPRNDINMWSKV 1814
Query: 751 YLEG------LGRSHIASPSPCPDRMPLPSPTESRHSLSIPP----VSSPPEQKVGLYRR 800
EG L RS A P+ L SR ++ +S Q
Sbjct: 1815 TEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVT 1874
Query: 801 QTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEMGGLSPAGDMSHVDAAAAAVP 860
QTEL +S F+ +E S + + +L + + A +
Sbjct: 1875 QTELMRES---------FRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVID 1925
Query: 861 LSYQHPSVDQKQIEEQKEEEKIREQQV---KERRQREERRQSNLQEVLERERRELEKLYQ 917
++ ++QI+E+ + EQ++ R Q E Q +QE E R+ E +
Sbjct: 1926 GYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKA 1985
Query: 918 ERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKS 977
E +E+ L + +K ++ + E++ ++++D L+K +K ++ + +++ +
Sbjct: 1986 EAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDD-------LQKQVKALEIDVEEQVSRFI 2038
Query: 978 SKKMVQEGSLVDTLQSSDKVESLTGFSHEELDD 1010
+ + L+D Q + +E + LD+
Sbjct: 2039 ELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE 2071
Score = 44.3 bits (103), Expect = 6e-04
Identities = 176/929 (18%), Positives = 371/929 (39%), Gaps = 147/929 (15%)
Query: 97 ESGLAKEKVFTM-QDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKE 155
E +K+K F + Q + I ++ + + +++ E+ + L+ +E + +
Sbjct: 1550 EEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLR 1609
Query: 156 SCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEM 215
+M +++ L E+++ ++ Q A QR ++ E ++E +R + E+L A
Sbjct: 1610 QAHMRQMERQREDQEQLQEEIKRLNRQLA----QRSSIDN-ENLVSERERVLLEELEA-- 1662
Query: 216 CQKLKFFKDTEIAKIKMEAKKKYEKEL----TMFQNDFEKACQAKSEALVLREKSTLERI 271
+ ++ + ++K EL T QN E Q + E +EK L+R
Sbjct: 1663 -----------LKQLSLAGREKLCCELRNSSTQTQNGNEN--QGEVEEQTFKEKE-LDRK 1708
Query: 272 HKH--QEIETKEIYAQRQL---LLKDMDLLRGREAELKQRVEAFELNQKLQEEKHKSITE 326
+ EI + E YA ++ LLK + + A +++ + L + K +S
Sbjct: 1709 PEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSAS 1768
Query: 327 ALRRQEQ--NIKS-FEETYDRKLKNELLKYQ-LELKDDYIIRTNRLIEDERKNKEKAVHL 382
+ R E ++KS E + R + Y ++ + I +++ E+ + ++ V
Sbjct: 1769 LIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRS 1828
Query: 383 QEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEKVKEMSDYSLLKE 442
I+ + EEL +++ + +E + ++A S ++ H + + M + K+
Sbjct: 1829 GFAGTEIDPENEELMLNISSRLQAAVE-KLLEAISETSSQLEHAKVTQTELMRESFRQKQ 1887
Query: 443 EKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQKELRKAEKAIVVEHEEFES 502
E E L + L+++L E ++ +LAV EL KAE I + +
Sbjct: 1888 EATESLKCQEELRERLHEE-----------SRAREQLAV---ELSKAEGVI----DGYAD 1929
Query: 503 CRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTT---QVADLKLQLKQTQTALENEVYC 559
+ +Q+Q++ + +L+ ++L ++ L Q+ + + L + + A++ E
Sbjct: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA-- 1987
Query: 560 NPKQSVIDRSVNGLINGNV-VPCNGEISGDFLNNPFKQENVLARMVASRITNYPTAWVEG 618
P + + + L+ + V C E D L KQ L V +++ + E
Sbjct: 1988 GPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQ---KQVKALEIDVEEQVSRFIELEQEK 2044
Query: 619 SSPDSDLEFVANTKARVKELQQEAERL-EKAFRSYHRRVIKNSAKSPLAAK-------SP 670
++ DL +A K+L++ + L E+A H R + L + P
Sbjct: 2045 NTELMDLR--QQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQP 2102
Query: 671 PSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGSAASRLRGGTS 730
S H + + + E+ + ++S++ ++ERN+ +E L R+R
Sbjct: 2103 ISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLE----FRVRELEQ 2158
Query: 731 SRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPD-----RMPLPSPTESRHSLSIP 785
+ +S+ K + R H + P+ ++ R I
Sbjct: 2159 ALLVSADTFQKVE------------DRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEIT 2206
Query: 786 PVSSPPEQ----------KVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMP 835
+ EQ +V Q E+Q K + + +L ++N+ F+ E G
Sbjct: 2207 NLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELE-QENKLFKDDMEKLGLAI 2265
Query: 836 RQLEMGGLSPAGDMSHVDAAAAAVPLSYQHPSVDQ------------------KQIEEQK 877
++ + + + HV A + + +DQ K IEE+
Sbjct: 2266 KESD----AMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKN 2321
Query: 878 EEEKIREQQVK--------ERRQREERRQSNLQEVLERERRELEKLYQERKM-------- 921
E + E Q++ +R REE + L EV+E+ ++EL + Q+ M
Sbjct: 2322 ELIRDLETQIECLMSDQECVKRNREEEIE-QLNEVIEKLQQELANIGQKTSMNAHSLSEE 2380
Query: 922 ---IEESLKIKIKKELEMENELEMSNQEI 947
++ L + I ++L +E ++E +N+E+
Sbjct: 2381 ADSLKHQLDVVIAEKLALEQQVETANEEM 2409
Score = 39.7 bits (91), Expect = 0.014
Identities = 66/310 (21%), Positives = 136/310 (43%), Gaps = 63/310 (20%)
Query: 197 EIKLNEYKREIEE-----QLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEK 251
+++L + ++I++ Q EM QK K +I + K+ A + +L Q ++ K
Sbjct: 2512 DLELTQCYKQIKDMQEQGQFETEMLQK-KIVNLQKIVEEKVAAALVSQIQLEAVQ-EYAK 2569
Query: 252 ACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFE 311
CQ E++ ++ +++ +E E L D+ L R +EL+ +V E
Sbjct: 2570 FCQDNQTISSEPERTNIQNLNQLREDE----------LGSDISALTLRISELESQV--VE 2617
Query: 312 LNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDDYIIRTNRLIE- 370
++ L EK E + E+N+ K+ ++ +L+E
Sbjct: 2618 MHTSLILEK-----EQVEIAEKNVLE--------------------KEKKLLELQKLLEG 2652
Query: 371 DERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAITKQNHMLNEK 430
+E+K +EK + + + EL S N ELE+++A+S+A + EK
Sbjct: 2653 NEKKQREKEKKRSPQDVEVLKTTTELFHS-NEESGFFNELEALRAESVATKAELASYKEK 2711
Query: 431 VKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELAVFQK----EL 486
+++ + L+KE + L++ L + R + LA+ +L++ +K E+
Sbjct: 2712 AEKLQEELLVKETNM------TSLQKDLSQVR-------DHLAEAKEKLSILEKEDETEV 2758
Query: 487 RKAEKAIVVE 496
++++KA + E
Sbjct: 2759 QESKKACMFE 2768
Score = 37.4 bits (85), Expect = 0.072
Identities = 28/135 (20%), Positives = 63/135 (46%), Gaps = 4/135 (2%)
Query: 875 EQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIEESLKIKIKKEL 934
E K E ++ ++K E+ + + L + E + ELE+L + E K+K++L
Sbjct: 586 ELKHEAEVTNYKIK-LEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDL 644
Query: 935 EMENELEMSNQEIKDK-SAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDTLQS 993
E+E+ + + +++KD H + ++ + Q+ + +K + Q +++ +
Sbjct: 645 EIEHRINI--EKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKL 702
Query: 994 SDKVESLTGFSHEEL 1008
D +SL EE+
Sbjct: 703 KDLQQSLVNSKSEEM 717
Score = 35.4 bits (80), Expect = 0.27
Identities = 23/88 (26%), Positives = 45/88 (51%), Gaps = 2/88 (2%)
Query: 864 QHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSNLQEVLERERRELEKLYQERKMIE 923
+ PS + + Q+++ ++ E QV+ ++ R + LQE L E+ + +L E +
Sbjct: 3115 EKPSQELLEYNIQQKQSQMLEMQVELSSMKD--RATELQEQLSSEKMVVAELKSELAQTK 3172
Query: 924 ESLKIKIKKELEMENELEMSNQEIKDKS 951
L+ +K + + ELE E+KDK+
Sbjct: 3173 LELETTLKAQHKHLKELEAFRLEVKDKT 3200
Score = 31.2 bits (69), Expect = 5.2
Identities = 25/129 (19%), Positives = 63/129 (48%), Gaps = 10/129 (7%)
Query: 875 EQKEEEKIREQQVKERRQREERRQSNLQEVLERERREL----EKLYQERKMIEESLKIKI 930
E++++E++ + + Q++ Q NL +LE++++ L +K+ +R + + L +
Sbjct: 3235 EERDKEELEDLKFSLESQKQRNLQLNL--LLEQQKQLLNESQQKIESQRMLYDAQLSEEQ 3292
Query: 931 KKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADKSSKKMVQEGSLVDT 990
+ LE++ LE I++ S + L++ ++ Q Q + +S + E L +
Sbjct: 3293 GRNLELQVLLESEKVRIREMS----STLDRERELHAQLQSSDGTGQSRPPLPSEDLLKEL 3348
Query: 991 LQSSDKVES 999
+ ++ S
Sbjct: 3349 QKQLEEKHS 3357
Score = 30.4 bits (67), Expect = 8.8
Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 17/115 (14%)
Query: 873 IEEQKEEEKIREQQVKERRQREERR-----------QSNLQEVLERERRELEKLYQERKM 921
+E++ +E+ + Q E Q+ +RR Q N +++ + +E EK QE +
Sbjct: 3064 LEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQE--L 3121
Query: 922 IEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEKYMKIIQQEQDQESADK 976
+E +++ K + LEM+ EL +KD++ + L ++ + + + + K
Sbjct: 3122 LEYNIQQKQSQMLEMQVEL----SSMKDRATELQEQLSSEKMVVAELKSELAQTK 3172
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.127 0.335
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,089,815
Number of Sequences: 37866
Number of extensions: 1713537
Number of successful extensions: 30329
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 550
Number of HSP's successfully gapped in prelim test: 1289
Number of HSP's that attempted gapping in prelim test: 10740
Number of HSP's gapped (non-prelim): 11029
length of query: 1012
length of database: 18,247,518
effective HSP length: 112
effective length of query: 900
effective length of database: 14,006,526
effective search space: 12605873400
effective search space used: 12605873400
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.