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Search of human proteins with 4502745
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502745 cyclin-dependent kinase 8 [Homo sapiens]
(464 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502745 cyclin-dependent kinase 8 [Homo sapiens] 970 0.0
gi|30387611 cell division cycle 2-like 6 (CDK8-like) [Homo sapiens] 781 0.0
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 206 5e-53
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 206 5e-53
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 206 5e-53
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 206 5e-53
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 206 5e-53
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 206 5e-53
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 205 8e-53
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 204 2e-52
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 204 2e-52
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] 199 4e-51
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens] 197 2e-50
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 196 3e-50
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens] 196 5e-50
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens] 189 4e-48
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2... 184 2e-46
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1... 184 2e-46
gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens] 181 1e-45
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens] 180 3e-45
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 179 6e-45
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens] 178 8e-45
gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens] 177 1e-44
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens] 176 5e-44
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens] 176 5e-44
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens] 170 3e-42
gi|4502735 cyclin-dependent kinase 4 [Homo sapiens] 169 4e-42
gi|237858580 cyclin-dependent kinase 10 isoform c [Homo sapiens] 166 5e-41
gi|4502747 cyclin-dependent kinase 9 [Homo sapiens] 165 7e-41
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens] 164 1e-40
>gi|4502745 cyclin-dependent kinase 8 [Homo sapiens]
Length = 464
Score = 970 bits (2508), Expect = 0.0
Identities = 464/464 (100%), Positives = 464/464 (100%)
Query: 1 MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGIS 60
MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGIS
Sbjct: 1 MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGIS 60
Query: 61 MSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKP 120
MSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKP
Sbjct: 61 MSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKP 120
Query: 121 VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF 180
VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF
Sbjct: 121 VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF 180
Query: 181 NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 240
NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED
Sbjct: 181 NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 240
Query: 241 IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH 300
IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH
Sbjct: 241 IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH 300
Query: 301 KVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLT 360
KVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLT
Sbjct: 301 KVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLT 360
Query: 361 EEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTS 420
EEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTS
Sbjct: 361 EEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTS 420
Query: 421 DYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY 464
DYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY
Sbjct: 421 DYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY 464
>gi|30387611 cell division cycle 2-like 6 (CDK8-like) [Homo sapiens]
Length = 502
Score = 781 bits (2018), Expect = 0.0
Identities = 389/502 (77%), Positives = 417/502 (83%), Gaps = 38/502 (7%)
Query: 1 MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGIS 60
MDYDFK KL++ERERVEDLFEYEGCKVGRGTYGHVYKA+RKDGKD+K+YALKQIEGTGIS
Sbjct: 1 MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGIS 60
Query: 61 MSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKP 120
MSACREIALLRELKHPNVI+LQKVFLSH+DRKVWLLFDYAEHDLWHIIKFHRASKANKKP
Sbjct: 61 MSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKP 120
Query: 121 VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF 180
+QLPR MVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF
Sbjct: 121 MQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF 180
Query: 181 NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 240
NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED
Sbjct: 181 NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 240
Query: 241 IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH 300
IKTSNP+HHDQLDRIF+VMGFPADKDWEDI+KMPE+ TL KDFRR TY N SLIKYMEKH
Sbjct: 241 IKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKH 300
Query: 301 KVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLT 360
KVKPDSK F LLQKLLTMDP KRITSEQA+QDPYF EDPLPT DVFAGCQIPYPKREFL
Sbjct: 301 KVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLN 360
Query: 361 EEEPDDKGDKKNQQQ-----------------------QQGNNHTNGT------------ 385
E++P++KGDK QQQ QQ + TNGT
Sbjct: 361 EDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTG 420
Query: 386 -GHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSS 444
G +QDSS Q PP KK R+ P SGG +M SDYQ S+ Y + +SQ QS+
Sbjct: 421 AGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQST 480
Query: 445 MGYSATSQQPPQY--SHQTHRY 464
+GYS++SQQ QY SHQ HRY
Sbjct: 481 LGYSSSSQQSSQYHPSHQAHRY 502
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 206 bits (523), Expect = 5e-53
Identities = 118/320 (36%), Positives = 188/320 (58%), Gaps = 37/320 (11%)
Query: 26 KVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL 81
++ GTYG VY+AK D K D+ ALK++ E G +++ REI + + +HPN++++
Sbjct: 419 RIEEGTYGVVYRAK--DKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 476
Query: 82 QKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHY 141
+++ + K++++ +Y EHDL +++ K+P LP G VK+L+ Q+L G+ +
Sbjct: 477 REIVVGSNMDKIYIVMNYVEHDLKSLME------TMKQPF-LP-GEVKTLMIQLLRGVKH 528
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
LH NW+LHRDLK +N+L+ G +K+ D G AR + SPLK PVVVT WYRA
Sbjct: 529 LHDNWILHRDLKTSNLLLS----HAGILKVGDFGLAREYGSPLKAYT---PVVVTLWYRA 581
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGF 261
PELLLGA+ Y+ A+D+W++GCIF ELLT +P+F + E DQ++++F +G
Sbjct: 582 PELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSE---------IDQINKVFKDLGT 632
Query: 262 PADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPI 321
P++K W ++P + F + Y N ++ + F L+ K LT P
Sbjct: 633 PSEKIWPGYSELP--AVKKMTFSEHPYNN-----LRKRFGALLSDQGFDLMNKFLTYFPG 685
Query: 322 KRITSEQAMQDPYFLEDPLP 341
+RI++E ++ YF E PLP
Sbjct: 686 RRISAEDGLKHEYFRETPLP 705
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 206 bits (523), Expect = 5e-53
Identities = 118/320 (36%), Positives = 188/320 (58%), Gaps = 37/320 (11%)
Query: 26 KVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL 81
++ GTYG VY+AK D K D+ ALK++ E G +++ REI + + +HPN++++
Sbjct: 428 RIEEGTYGVVYRAK--DKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 485
Query: 82 QKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHY 141
+++ + K++++ +Y EHDL +++ K+P LP G VK+L+ Q+L G+ +
Sbjct: 486 REIVVGSNMDKIYIVMNYVEHDLKSLME------TMKQPF-LP-GEVKTLMIQLLRGVKH 537
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
LH NW+LHRDLK +N+L+ G +K+ D G AR + SPLK PVVVT WYRA
Sbjct: 538 LHDNWILHRDLKTSNLLLS----HAGILKVGDFGLAREYGSPLKAYT---PVVVTLWYRA 590
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGF 261
PELLLGA+ Y+ A+D+W++GCIF ELLT +P+F + E DQ++++F +G
Sbjct: 591 PELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSE---------IDQINKVFKDLGT 641
Query: 262 PADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPI 321
P++K W ++P + F + Y N ++ + F L+ K LT P
Sbjct: 642 PSEKIWPGYSELP--AVKKMTFSEHPYNN-----LRKRFGALLSDQGFDLMNKFLTYFPG 694
Query: 322 KRITSEQAMQDPYFLEDPLP 341
+RI++E ++ YF E PLP
Sbjct: 695 RRISAEDGLKHEYFRETPLP 714
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 206 bits (523), Expect = 5e-53
Identities = 118/320 (36%), Positives = 188/320 (58%), Gaps = 37/320 (11%)
Query: 26 KVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL 81
++ GTYG VY+AK D K D+ ALK++ E G +++ REI + + +HPN++++
Sbjct: 396 RIEEGTYGVVYRAK--DKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 453
Query: 82 QKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHY 141
+++ + K++++ +Y EHDL +++ K+P LP G VK+L+ Q+L G+ +
Sbjct: 454 REIVVGSNMDKIYIVMNYVEHDLKSLME------TMKQPF-LP-GEVKTLMIQLLRGVKH 505
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
LH NW+LHRDLK +N+L+ G +K+ D G AR + SPLK PVVVT WYRA
Sbjct: 506 LHDNWILHRDLKTSNLLLS----HAGILKVGDFGLAREYGSPLKAYT---PVVVTLWYRA 558
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGF 261
PELLLGA+ Y+ A+D+W++GCIF ELLT +P+F + E DQ++++F +G
Sbjct: 559 PELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSE---------IDQINKVFKDLGT 609
Query: 262 PADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPI 321
P++K W ++P + F + Y N ++ + F L+ K LT P
Sbjct: 610 PSEKIWPGYSELP--AVKKMTFSEHPYNN-----LRKRFGALLSDQGFDLMNKFLTYFPG 662
Query: 322 KRITSEQAMQDPYFLEDPLP 341
+RI++E ++ YF E PLP
Sbjct: 663 RRISAEDGLKHEYFRETPLP 682
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 206 bits (523), Expect = 5e-53
Identities = 118/320 (36%), Positives = 188/320 (58%), Gaps = 37/320 (11%)
Query: 26 KVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL 81
++ GTYG VY+AK D K D+ ALK++ E G +++ REI + + +HPN++++
Sbjct: 385 RIEEGTYGVVYRAK--DKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 442
Query: 82 QKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHY 141
+++ + K++++ +Y EHDL +++ K+P LP G VK+L+ Q+L G+ +
Sbjct: 443 REIVVGSNMDKIYIVMNYVEHDLKSLME------TMKQPF-LP-GEVKTLMIQLLRGVKH 494
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
LH NW+LHRDLK +N+L+ G +K+ D G AR + SPLK PVVVT WYRA
Sbjct: 495 LHDNWILHRDLKTSNLLLS----HAGILKVGDFGLAREYGSPLKAYT---PVVVTLWYRA 547
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGF 261
PELLLGA+ Y+ A+D+W++GCIF ELLT +P+F + E DQ++++F +G
Sbjct: 548 PELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSE---------IDQINKVFKDLGT 598
Query: 262 PADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPI 321
P++K W ++P + F + Y N ++ + F L+ K LT P
Sbjct: 599 PSEKIWPGYSELP--AVKKMTFSEHPYNN-----LRKRFGALLSDQGFDLMNKFLTYFPG 651
Query: 322 KRITSEQAMQDPYFLEDPLP 341
+RI++E ++ YF E PLP
Sbjct: 652 RRISAEDGLKHEYFRETPLP 671
>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
3 [Homo sapiens]
Length = 526
Score = 206 bits (523), Expect = 5e-53
Identities = 118/320 (36%), Positives = 188/320 (58%), Gaps = 37/320 (11%)
Query: 26 KVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL 81
++ GTYG VY+AK D K D+ ALK++ E G +++ REI + + +HPN++++
Sbjct: 174 RIEEGTYGVVYRAK--DKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 231
Query: 82 QKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHY 141
+++ + K++++ +Y EHDL +++ K+P LP G VK+L+ Q+L G+ +
Sbjct: 232 REIVVGSNMDKIYIVMNYVEHDLKSLME------TMKQPF-LP-GEVKTLMIQLLRGVKH 283
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
LH NW+LHRDLK +N+L+ G +K+ D G AR + SPLK PVVVT WYRA
Sbjct: 284 LHDNWILHRDLKTSNLLLS----HAGILKVGDFGLAREYGSPLKAYT---PVVVTLWYRA 336
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGF 261
PELLLGA+ Y+ A+D+W++GCIF ELLT +P+F + E DQ++++F +G
Sbjct: 337 PELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSE---------IDQINKVFKDLGT 387
Query: 262 PADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPI 321
P++K W ++P + F + Y N ++ + F L+ K LT P
Sbjct: 388 PSEKIWPGYSELP--AVKKMTFSEHPYNN-----LRKRFGALLSDQGFDLMNKFLTYFPG 440
Query: 322 KRITSEQAMQDPYFLEDPLP 341
+RI++E ++ YF E PLP
Sbjct: 441 RRISAEDGLKHEYFRETPLP 460
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 206 bits (523), Expect = 5e-53
Identities = 118/320 (36%), Positives = 188/320 (58%), Gaps = 37/320 (11%)
Query: 26 KVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL 81
++ GTYG VY+AK D K D+ ALK++ E G +++ REI + + +HPN++++
Sbjct: 430 RIEEGTYGVVYRAK--DKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 487
Query: 82 QKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHY 141
+++ + K++++ +Y EHDL +++ K+P LP G VK+L+ Q+L G+ +
Sbjct: 488 REIVVGSNMDKIYIVMNYVEHDLKSLME------TMKQPF-LP-GEVKTLMIQLLRGVKH 539
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
LH NW+LHRDLK +N+L+ G +K+ D G AR + SPLK PVVVT WYRA
Sbjct: 540 LHDNWILHRDLKTSNLLLS----HAGILKVGDFGLAREYGSPLKAYT---PVVVTLWYRA 592
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGF 261
PELLLGA+ Y+ A+D+W++GCIF ELLT +P+F + E DQ++++F +G
Sbjct: 593 PELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSE---------IDQINKVFKDLGT 643
Query: 262 PADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPI 321
P++K W ++P + F + Y N ++ + F L+ K LT P
Sbjct: 644 PSEKIWPGYSELP--AVKKMTFSEHPYNN-----LRKRFGALLSDQGFDLMNKFLTYFPG 696
Query: 322 KRITSEQAMQDPYFLEDPLP 341
+RI++E ++ YF E PLP
Sbjct: 697 RRISAEDGLKHEYFRETPLP 716
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 205 bits (521), Expect = 8e-53
Identities = 124/323 (38%), Positives = 187/323 (57%), Gaps = 41/323 (12%)
Query: 26 KVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL 81
K+G GTYG VYKAK ++ + ALK+I E G+ +A REI+LL+ELKHPN++ L
Sbjct: 9 KIGEGTYGVVYKAKNRE--TGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRL 66
Query: 82 QKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHY 141
V H +RK++L+F++ DL + S +LP ++KS L+Q+L G+ +
Sbjct: 67 LDVV--HNERKLYLVFEFLSQDLKKYMDSTPGS-------ELPLHLIKSYLFQLLQGVSF 117
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
H++ V+HRDLKP N+L+ E G +K+AD G AR F PL+ VVT WYRA
Sbjct: 118 CHSHRVIHRDLKPQNLLIN----ELGAIKLADFGLARAFGVPLRTYTH---EVVTLWYRA 170
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGF 261
PE+LLG++ YT A+DIW+IGCIFAE++T + +F E DQL RIF ++G
Sbjct: 171 PEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSE---------IDQLFRIFRMLGT 221
Query: 262 PADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPI 321
P++ W + ++P++ + R K +E+ + + LL +LL DP
Sbjct: 222 PSEDTWPGVTQLPDYKGSFPKWTR---------KGLEEIVPNLEPEGRDLLMQLLQYDPS 272
Query: 322 KRITSEQAMQDPYFLE-DPLPTS 343
+RIT++ A+ PYF +P P +
Sbjct: 273 QRITAKTALAHPYFSSPEPSPAA 295
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 204 bits (518), Expect = 2e-52
Identities = 118/320 (36%), Positives = 187/320 (58%), Gaps = 37/320 (11%)
Query: 26 KVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL 81
++ GTYG VY+AK D K D+ ALK++ E G +++ REI + + +HPN++++
Sbjct: 418 RIEEGTYGVVYRAK--DKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 475
Query: 82 QKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHY 141
+++ + K++++ +Y EHDL +++ K+P LP G VK+L+ Q+L G+ +
Sbjct: 476 REIVVGSNMDKIYIVMNYVEHDLKSLME------TMKQPF-LP-GEVKTLMIQLLRGVKH 527
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
LH NW+LHRDLK +N+L+ G +K+ D G AR + SPLK PVVVT WYRA
Sbjct: 528 LHDNWILHRDLKTSNLLLS----HAGILKVGDFGLAREYGSPLKAYT---PVVVTQWYRA 580
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGF 261
PELLLGA+ Y+ A+D+W++GCIF ELLT +P+F E DQ++++F +G
Sbjct: 581 PELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSE---------IDQINKVFKELGT 631
Query: 262 PADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPI 321
P++K W ++P + F + Y N ++ + F L+ K LT P
Sbjct: 632 PSEKIWPGYSELPVVKKM--TFSEHPYNN-----LRKRFGALLSDQGFDLMNKFLTYFPG 684
Query: 322 KRITSEQAMQDPYFLEDPLP 341
+RI++E ++ YF E PLP
Sbjct: 685 RRISAEDGLKHEYFRETPLP 704
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 204 bits (518), Expect = 2e-52
Identities = 118/320 (36%), Positives = 187/320 (58%), Gaps = 37/320 (11%)
Query: 26 KVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL 81
++ GTYG VY+AK D K D+ ALK++ E G +++ REI + + +HPN++++
Sbjct: 428 RIEEGTYGVVYRAK--DKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 485
Query: 82 QKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHY 141
+++ + K++++ +Y EHDL +++ K+P LP G VK+L+ Q+L G+ +
Sbjct: 486 REIVVGSNMDKIYIVMNYVEHDLKSLME------TMKQPF-LP-GEVKTLMIQLLRGVKH 537
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
LH NW+LHRDLK +N+L+ G +K+ D G AR + SPLK PVVVT WYRA
Sbjct: 538 LHDNWILHRDLKTSNLLLS----HAGILKVGDFGLAREYGSPLKAYT---PVVVTQWYRA 590
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGF 261
PELLLGA+ Y+ A+D+W++GCIF ELLT +P+F E DQ++++F +G
Sbjct: 591 PELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSE---------IDQINKVFKELGT 641
Query: 262 PADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPI 321
P++K W ++P + F + Y N ++ + F L+ K LT P
Sbjct: 642 PSEKIWPGYSELPVVKKM--TFSEHPYNN-----LRKRFGALLSDQGFDLMNKFLTYFPG 694
Query: 322 KRITSEQAMQDPYFLEDPLP 341
+RI++E ++ YF E PLP
Sbjct: 695 RRISAEDGLKHEYFRETPLP 714
>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
Length = 297
Score = 199 bits (506), Expect = 4e-51
Identities = 121/325 (37%), Positives = 181/325 (55%), Gaps = 43/325 (13%)
Query: 16 VEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLR 71
+ED + E K+G GTYG VYK + K + A+K+I E G+ +A REI+LL+
Sbjct: 1 MEDYTKIE--KIGEGTYGVVYKGRHKT--TGQVVAMKKIRLESEEEGVPSTAIREISLLK 56
Query: 72 ELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQ-LPRGMVKS 130
EL+HPN++SLQ V + D +++L+F++ DL + + P Q + +VKS
Sbjct: 57 ELRHPNIVSLQDVLMQ--DSRLYLIFEFLSMDLKKYLD-------SIPPGQYMDSSLVKS 107
Query: 131 LLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADL 190
LYQIL GI + H+ VLHRDLKP N+L+ ++G +K+AD G AR F P++
Sbjct: 108 YLYQILQGIVFCHSRRVLHRDLKPQNLLI----DDKGTIKLADFGLARAFGIPIRVYTH- 162
Query: 191 DPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHD 250
VVT WYR+PE+LLG+ Y+ +DIW+IG IFAEL T +P+FH E D
Sbjct: 163 --EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSE---------ID 211
Query: 251 QLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFH 310
QL RIF +G P ++ W +++ + ++ ++ + + H D
Sbjct: 212 QLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGS---------LASHVKNLDENGLD 262
Query: 311 LLQKLLTMDPIKRITSEQAMQDPYF 335
LL K+L DP KRI+ + A+ PYF
Sbjct: 263 LLSKMLIYDPAKRISGKMALNHPYF 287
>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
Length = 297
Score = 197 bits (501), Expect = 2e-50
Identities = 119/325 (36%), Positives = 180/325 (55%), Gaps = 43/325 (13%)
Query: 16 VEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLR 71
+ED + E K+G GTYG VYK + K + A+K+I E G+ +A REI+LL+
Sbjct: 1 MEDYTKIE--KIGEGTYGVVYKGRHKT--TGQVVAMKKIRLESEEEGVPSTAIREISLLK 56
Query: 72 ELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQ-LPRGMVKS 130
EL+HPN++SLQ V + D +++L+F++ DL + + P Q + +VKS
Sbjct: 57 ELRHPNIVSLQDVLMQ--DSRLYLIFEFLSMDLKKYLD-------SIPPGQYMDSSLVKS 107
Query: 131 LLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADL 190
LYQIL GI + H+ VLHRDLKP N+L+ ++G +K+AD G AR F P++
Sbjct: 108 YLYQILQGIVFCHSRRVLHRDLKPQNLLI----DDKGTIKLADFGLARAFGIPIRVYTH- 162
Query: 191 DPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHD 250
+T WYR+PE+LLG+ Y+ +DIW+IG IFAEL T +P+FH E D
Sbjct: 163 --EAITLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSE---------ID 211
Query: 251 QLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFH 310
QL RIF +G P ++ W +++ + ++ ++ + + H D
Sbjct: 212 QLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGS---------LASHVKNLDENGLD 262
Query: 311 LLQKLLTMDPIKRITSEQAMQDPYF 335
LL K+L DP KRI+ + A+ PYF
Sbjct: 263 LLSKMLIYDPAKRISGKMALNHPYF 287
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 196 bits (499), Expect = 3e-50
Identities = 123/322 (38%), Positives = 179/322 (55%), Gaps = 44/322 (13%)
Query: 26 KVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL 81
K+G GTYG VYKA+ K + ALK+I E G+ +A REI+LL+EL HPN++ L
Sbjct: 9 KIGEGTYGVVYKARNK--LTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 66
Query: 82 QKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHY 141
V H + K++L+F++ DL KF AS P+ L +KS L+Q+L G+ +
Sbjct: 67 LDVI--HTENKLYLVFEFLHQDLK---KFMDASALTGIPLPL----IKSYLFQLLQGLAF 117
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
H++ VLHRDLKP N+L+ EG +K+AD G AR F P++ VVT WYRA
Sbjct: 118 CHSHRVLHRDLKPQNLLINTEGA----IKLADFGLARAFGVPVRTYTH---EVVTLWYRA 170
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGF 261
PE+LLG ++Y+ A+DIW++GCIFAE++T +F E DQL RIF +G
Sbjct: 171 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSE---------IDQLFRIFRTLGT 221
Query: 262 PADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKP--DSKAFHLLQKLLTMD 319
P + W + MP++ + R ++ KV P D LL ++L D
Sbjct: 222 PDEVVWPGVTSMPDYKPSFPKWARQDFS-----------KVVPPLDEDGRSLLSQMLHYD 270
Query: 320 PIKRITSEQAMQDPYFLEDPLP 341
P KRI+++ A+ P+F + P
Sbjct: 271 PNKRISAKAALAHPFFQDVTKP 292
>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
Length = 360
Score = 196 bits (497), Expect = 5e-50
Identities = 121/321 (37%), Positives = 174/321 (54%), Gaps = 40/321 (12%)
Query: 26 KVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL 81
++G GTYG VY+A+ D + D+ ALK++ E GI +S+ REI LL L+HPN++ L
Sbjct: 44 RIGEGTYGIVYRAR--DTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVEL 101
Query: 82 QKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHY 141
++V + + ++L+ Y E DL AS P VK ++ Q+L G+ Y
Sbjct: 102 KEVVVGNHLESIFLVMGYCEQDL--------ASLLENMPTPFSEAQVKCIVLQVLRGLQY 153
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
LH N+++HRDLK +N+L+ ++G VK AD G AR + P+KP+ P VVT WYRA
Sbjct: 154 LHRNFIIHRDLKVSNLLMT----DKGCVKTADFGLARAYGVPVKPMT---PKVVTLWYRA 206
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGF 261
PELLLG T +ID+WA+GCI AELL P+ + ++ H Q+D I ++G
Sbjct: 207 PELLLGTTTQTTSIDMWAVGCILAELLAHRPL-------LPGTSEIH--QIDLIVQLLGT 257
Query: 262 PADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKA-FHLLQKLLTMDP 320
P++ W K+P R+ Y N KHK S+A LL L DP
Sbjct: 258 PSENIWPGFSKLP--LVGQYSLRKQPYNNL-------KHKFPWLSEAGLRLLHFLFMYDP 308
Query: 321 IKRITSEQAMQDPYFLEDPLP 341
KR T+ ++ YF E PLP
Sbjct: 309 KKRATAGDCLESSYFKEKPLP 329
>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
Length = 292
Score = 189 bits (481), Expect = 4e-48
Identities = 118/315 (37%), Positives = 182/315 (57%), Gaps = 42/315 (13%)
Query: 26 KVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL 81
K+G GTYG V+KAK ++ + ALK++ + G+ SA REI LL+ELKH N++ L
Sbjct: 9 KIGEGTYGTVFKAKNRETHEI--VALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 66
Query: 82 QKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHY 141
V H+D+K+ L+F++ + DL K+ + + P +VKS L+Q+L G+ +
Sbjct: 67 HDVL--HSDKKLTLVFEFCDQDLK---KYFDSCNGDLDPE-----IVKSFLFQLLKGLGF 116
Query: 142 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 201
H+ VLHRDLKP N+L+ G +K+AD G AR F P++ + VVT WYR
Sbjct: 117 CHSRNVLHRDLKPQNLLIN----RNGELKLADFGLARAFGIPVRCYS---AEVVTLWYRP 169
Query: 202 PELLLGARHYTKAIDIWAIGCIFAELLTS-EPIFHCRQEDIKTSNPYHHDQLDRIFNVMG 260
P++L GA+ Y+ +ID+W+ GCIFAEL + P+F D DQL RIF ++G
Sbjct: 170 PDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVD---------DQLKRIFRLLG 220
Query: 261 FPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDP 320
P ++ W + K+P++ K + T SL+ + K ++ LLQ LL +P
Sbjct: 221 TPTEEQWPSMTKLPDY----KPYPMYPATT-SLVNVVP----KLNATGRDLLQNLLKCNP 271
Query: 321 IKRITSEQAMQDPYF 335
++RI++E+A+Q PYF
Sbjct: 272 VQRISAEEALQHPYF 286
>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
[Homo sapiens]
Length = 1481
Score = 184 bits (466), Expect = 2e-46
Identities = 144/455 (31%), Positives = 215/455 (47%), Gaps = 80/455 (17%)
Query: 14 ERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIAL 69
+R D F+ G +G GTYG VYKAK KD + ALK++ E G ++A REI +
Sbjct: 721 KRCVDKFDIIGI-IGEGTYGQVYKAKDKD--TGELVALKKVRLDNEKEGFPITAIREIKI 777
Query: 70 LRELKHPNVISLQKVFLSHADR--------KVWLLFDYAEHDLWHIIKFHRASKANKKPV 121
LR+L H +V++++++ D +L+F+Y +HDL +++ V
Sbjct: 778 LRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLE--------SGLV 829
Query: 122 QLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFN 181
+KS + Q+++G+ Y H LHRD+K +NIL+ G ++K+AD G ARL+N
Sbjct: 830 HFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSG----QIKLADFGLARLYN 885
Query: 182 SP-LKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 240
S +P + V+T WYR PELLLG YT AID+W+ GCI EL T +PIF E
Sbjct: 886 SEESRPYTNK---VITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLE- 941
Query: 241 IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTL--MKDFRRNTYTNCSLIKYME 298
QL+ I + G P W D+ K+P +T+ K +RR S I
Sbjct: 942 --------LAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFI---- 989
Query: 299 KHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREF 358
S A LL +LT+DP KR T+EQ +Q + + L A +P+
Sbjct: 990 ------PSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVEL---SKMAPPDLPH----- 1035
Query: 359 LTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIM 418
++ + KK ++Q+Q + PP K R TTSG
Sbjct: 1036 --WQDCHELWSKKRRRQRQSGVVVE-------------EPPPSKTSR---KETTSG--TS 1075
Query: 419 TSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQ 453
T + S+P P PG S ++G + +QQ
Sbjct: 1076 TEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQ 1110
>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
[Homo sapiens]
Length = 1490
Score = 184 bits (466), Expect = 2e-46
Identities = 144/455 (31%), Positives = 215/455 (47%), Gaps = 80/455 (17%)
Query: 14 ERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIAL 69
+R D F+ G +G GTYG VYKAK KD + ALK++ E G ++A REI +
Sbjct: 721 KRCVDKFDIIGI-IGEGTYGQVYKAKDKD--TGELVALKKVRLDNEKEGFPITAIREIKI 777
Query: 70 LRELKHPNVISLQKVFLSHADR--------KVWLLFDYAEHDLWHIIKFHRASKANKKPV 121
LR+L H +V++++++ D +L+F+Y +HDL +++ V
Sbjct: 778 LRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLE--------SGLV 829
Query: 122 QLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFN 181
+KS + Q+++G+ Y H LHRD+K +NIL+ G ++K+AD G ARL+N
Sbjct: 830 HFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSG----QIKLADFGLARLYN 885
Query: 182 SP-LKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 240
S +P + V+T WYR PELLLG YT AID+W+ GCI EL T +PIF E
Sbjct: 886 SEESRPYTNK---VITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLE- 941
Query: 241 IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTL--MKDFRRNTYTNCSLIKYME 298
QL+ I + G P W D+ K+P +T+ K +RR S I
Sbjct: 942 --------LAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFI---- 989
Query: 299 KHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREF 358
S A LL +LT+DP KR T+EQ +Q + + L A +P+
Sbjct: 990 ------PSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVEL---SKMAPPDLPH----- 1035
Query: 359 LTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIM 418
++ + KK ++Q+Q + PP K R TTSG
Sbjct: 1036 --WQDCHELWSKKRRRQRQSGVVVE-------------EPPPSKTSR---KETTSG--TS 1075
Query: 419 TSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQ 453
T + S+P P PG S ++G + +QQ
Sbjct: 1076 TEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQ 1110
>gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens]
Length = 272
Score = 181 bits (460), Expect = 1e-45
Identities = 113/301 (37%), Positives = 159/301 (52%), Gaps = 36/301 (11%)
Query: 55 EGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRAS 114
E GI +S+ REI LL L+HPN++ L++V + + ++L+ Y E DL AS
Sbjct: 4 EKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDL--------AS 55
Query: 115 KANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADM 174
P VK ++ Q+L G+ YLH N+++HRDLK +N+L+ ++G VK AD
Sbjct: 56 LLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMT----DKGCVKTADF 111
Query: 175 GFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIF 234
G AR + P+KP+ P VVT WYRAPELLLG T +ID+WA+GCI AELL P+
Sbjct: 112 GLARAYGVPVKPMT---PKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPL- 167
Query: 235 HCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLI 294
+ ++ H Q+D I ++G P++ W K+P R+ Y N
Sbjct: 168 ------LPGTSEIH--QIDLIVQLLGTPSENIWPGFSKLP--LVGQYSLRKQPYNNL--- 214
Query: 295 KYMEKHKVKPDSKA-FHLLQKLLTMDPIKRITSEQAMQDPYFLEDP--LPTSDVFAGCQI 351
KHK S+A LL L DP KR T+ ++ YF E P LP S V GC+
Sbjct: 215 ----KHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLRLPISGVCEGCRE 270
Query: 352 P 352
P
Sbjct: 271 P 271
>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
Length = 1452
Score = 180 bits (456), Expect = 3e-45
Identities = 144/452 (31%), Positives = 217/452 (48%), Gaps = 78/452 (17%)
Query: 14 ERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIAL 69
+R D F+ G +G GTYG VYKA+ KD + ALK++ E G ++A REI +
Sbjct: 699 KRCVDKFDIIGI-IGEGTYGQVYKARDKD--TGEMVALKKVRLDNEKEGFPITAIREIKI 755
Query: 70 LRELKHPNVISLQKVFLSHADR--------KVWLLFDYAEHDLWHIIKFHRASKANKKPV 121
LR+L H ++I+++++ D +L+F+Y +HDL +++ V
Sbjct: 756 LRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLE--------SGLV 807
Query: 122 QLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFN 181
+KS + Q+++G+ Y H LHRD+K +NIL+ RG++K+AD G ARL++
Sbjct: 808 HFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNN----RGQIKLADFGLARLYS 863
Query: 182 SP-LKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 240
S +P + V+T WYR PELLLG YT AID+W+ GCI EL T +PIF QE
Sbjct: 864 SEESRPYTNK---VITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQE- 919
Query: 241 IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTL--MKDFRRNTYTNCSLIKYME 298
QL+ I + G P W D+ K+P +T+ K +RR K E
Sbjct: 920 --------LAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRR---------KLRE 962
Query: 299 KHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREF 358
+ P + A L +L +DP KR T+EQA+Q FL D P+ P +
Sbjct: 963 EFVFIP-AAALDLFDYMLALDPSKRCTAEQALQCE-FLRDVEPSK---------MPPPDL 1011
Query: 359 LTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRV---VPPTTTSGG 415
++ + KK ++Q+Q G D T P K + + T T G
Sbjct: 1012 PLWQDCHELWSKKRRRQKQ----------MGMTDDVSTIKAPRKDLSLGLDDSRTNTPQG 1061
Query: 416 LIMTSDYQ---RSNPHAAYPNPGPSTSQPQSS 444
++ +S + SN PST Q +SS
Sbjct: 1062 VLPSSQLKSQGSSNVAPGEKQTDPSTPQQESS 1093
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 179 bits (453), Expect = 6e-45
Identities = 127/363 (34%), Positives = 182/363 (50%), Gaps = 53/363 (14%)
Query: 27 VGRGTYGHVYKAKRKDGKDDKDYALKQIE-------GTGISMSACREIALLRELKHPNVI 79
+G G + VYKA+ K+ ++ A+K+I+ GI+ +A REI LL+EL HPN+I
Sbjct: 18 LGEGQFATVYKARDKN--TNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75
Query: 80 SLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGI 139
L F ++ + L+FD+ E DL IIK + L +K+ + L G+
Sbjct: 76 GLLDAFGHKSN--ISLVFDFMETDLEVIIK--------DNSLVLTPSHIKAYMLMTLQGL 125
Query: 140 HYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWY 199
YLH +W+LHRDLKP N+L+ E G +K+AD G A+ F SP + VVT WY
Sbjct: 126 EYLHQHWILHRDLKPNNLLL----DENGVLKLADFGLAKSFGSPNRAYTHQ---VVTRWY 178
Query: 200 RAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVM 259
RAPELL GAR Y +D+WA+GCI AELL P F D+ DQL RIF +
Sbjct: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLRVP-FLPGDSDL--------DQLTRIFETL 229
Query: 260 GFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMD 319
G P ++ W D+ +P++ T ++ L L+Q L +
Sbjct: 230 GTPTEEQWPDMCSLPDYVTF------KSFPGIPLHHIFS----AAGDDLLDLIQGLFLFN 279
Query: 320 PIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKG----DKKNQQQ 375
P RIT+ QA++ YF P PT GCQ+P P T +E + K+ +
Sbjct: 280 PCARITATQALKMKYFSNRPGPT----PGCQLPRPNCPVETLKEQSNPALAIKRKRTEAL 335
Query: 376 QQG 378
+QG
Sbjct: 336 EQG 338
>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
Length = 1512
Score = 178 bits (452), Expect = 8e-45
Identities = 122/344 (35%), Positives = 181/344 (52%), Gaps = 53/344 (15%)
Query: 14 ERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIAL 69
+R D F+ G +G GTYG VYKA+ KD + ALK++ E G ++A REI +
Sbjct: 699 KRCVDKFDIIGI-IGEGTYGQVYKARDKD--TGEMVALKKVRLDNEKEGFPITAIREIKI 755
Query: 70 LRELKHPNVISLQKVFLSHADR--------KVWLLFDYAEHDLWHIIKFHRASKANKKPV 121
LR+L H ++I+++++ D +L+F+Y +HDL +++ V
Sbjct: 756 LRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLE--------SGLV 807
Query: 122 QLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFN 181
+KS + Q+++G+ Y H LHRD+K +NIL+ RG++K+AD G ARL++
Sbjct: 808 HFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNN----RGQIKLADFGLARLYS 863
Query: 182 SP-LKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED 240
S +P + V+T WYR PELLLG YT AID+W+ GCI EL T +PIF QE
Sbjct: 864 SEESRPYTNK---VITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQE- 919
Query: 241 IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTL--MKDFRRNTYTNCSLIKYME 298
QL+ I + G P W D+ K+P +T+ K +RR K E
Sbjct: 920 --------LAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRR---------KLRE 962
Query: 299 KHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPT 342
+ P + A L +L +DP KR T+EQA+Q FL D P+
Sbjct: 963 EFVFIP-AAALDLFDYMLALDPSKRCTAEQALQCE-FLRDVEPS 1004
>gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]
Length = 289
Score = 177 bits (450), Expect = 1e-44
Identities = 108/288 (37%), Positives = 153/288 (53%), Gaps = 34/288 (11%)
Query: 55 EGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRAS 114
E GI +S+ REI LL L+HPN++ L++V + + ++L+ Y E DL AS
Sbjct: 4 EKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDL--------AS 55
Query: 115 KANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADM 174
P VK ++ Q+L G+ YLH N+++HRDLK +N+L+ ++G VK AD
Sbjct: 56 LLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMT----DKGCVKTADF 111
Query: 175 GFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIF 234
G AR + P+KP+ P VVT WYRAPELLLG T +ID+WA+GCI AELL P+
Sbjct: 112 GLARAYGVPVKPMT---PKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPL- 167
Query: 235 HCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLI 294
+ ++ H Q+D I ++G P++ W K+P R+ Y N
Sbjct: 168 ------LPGTSEIH--QIDLIVQLLGTPSENIWPGFSKLP--LVGQYSLRKQPYNNL--- 214
Query: 295 KYMEKHKVKPDSKA-FHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLP 341
KHK S+A LL L DP KR T+ ++ YF E PLP
Sbjct: 215 ----KHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLP 258
>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
Length = 502
Score = 176 bits (445), Expect = 5e-44
Identities = 124/359 (34%), Positives = 177/359 (49%), Gaps = 59/359 (16%)
Query: 26 KVGRGTYGHVYKAKRKDGKDDKDYALKQIE---GTGISMSACREIALLRELKHPNVISLQ 82
K+G GTY VYK K K D ALK+I G +A RE++LL++LKH N+++L
Sbjct: 176 KLGEGTYATVYKGKSK--LTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLH 233
Query: 83 KVFLSHADRKVWLLFDYAEHDL-------WHIIKFHRASKANKKPVQLPRGMVKSLLYQI 135
+ H ++ + L+F+Y + DL +II H VK L+Q+
Sbjct: 234 DII--HTEKSLTLVFEYLDKDLKQYLDDCGNIINMHN---------------VKLFLFQL 276
Query: 136 LDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVV 195
L G+ Y H VLHRDLKP N+L+ ERG +K+AD G AR + P K ++ VV
Sbjct: 277 LRGLAYCHRQKVLHRDLKPQNLLIN----ERGELKLADFGLARAKSIPTKTYSN---EVV 329
Query: 196 TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRI 255
T WYR P++LLG+ Y+ ID+W +GCIF E+ T P+F +QL I
Sbjct: 330 TLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLF---------PGSTVEEQLHFI 380
Query: 256 FNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKL 315
F ++G P ++ W I E K + Y +L+ H + DS LL KL
Sbjct: 381 FRILGTPTEETWPGILSNEE----FKTYNYPKYRAEALL----SHAPRLDSDGADLLTKL 432
Query: 316 LTMDPIKRITSEQAMQDPYFLE-----DPLP-TSDVFAGCQIPYPKREFLTEEEPDDKG 368
L + RI++E AM+ P+FL LP T+ +FA +I K L D G
Sbjct: 433 LQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDSG 491
>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
Length = 496
Score = 176 bits (445), Expect = 5e-44
Identities = 124/359 (34%), Positives = 177/359 (49%), Gaps = 59/359 (16%)
Query: 26 KVGRGTYGHVYKAKRKDGKDDKDYALKQIE---GTGISMSACREIALLRELKHPNVISLQ 82
K+G GTY VYK K K D ALK+I G +A RE++LL++LKH N+++L
Sbjct: 170 KLGEGTYATVYKGKSK--LTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLH 227
Query: 83 KVFLSHADRKVWLLFDYAEHDL-------WHIIKFHRASKANKKPVQLPRGMVKSLLYQI 135
+ H ++ + L+F+Y + DL +II H VK L+Q+
Sbjct: 228 DII--HTEKSLTLVFEYLDKDLKQYLDDCGNIINMHN---------------VKLFLFQL 270
Query: 136 LDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVV 195
L G+ Y H VLHRDLKP N+L+ ERG +K+AD G AR + P K ++ VV
Sbjct: 271 LRGLAYCHRQKVLHRDLKPQNLLIN----ERGELKLADFGLARAKSIPTKTYSN---EVV 323
Query: 196 TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRI 255
T WYR P++LLG+ Y+ ID+W +GCIF E+ T P+F +QL I
Sbjct: 324 TLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLF---------PGSTVEEQLHFI 374
Query: 256 FNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKL 315
F ++G P ++ W I E K + Y +L+ H + DS LL KL
Sbjct: 375 FRILGTPTEETWPGILSNEE----FKTYNYPKYRAEALL----SHAPRLDSDGADLLTKL 426
Query: 316 LTMDPIKRITSEQAMQDPYFLE-----DPLP-TSDVFAGCQIPYPKREFLTEEEPDDKG 368
L + RI++E AM+ P+FL LP T+ +FA +I K L D G
Sbjct: 427 LQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDSG 485
>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
Length = 523
Score = 170 bits (430), Expect = 3e-42
Identities = 120/359 (33%), Positives = 180/359 (50%), Gaps = 45/359 (12%)
Query: 26 KVGRGTYGHVYKAKRKDGKDDKDYALKQIE---GTGISMSACREIALLRELKHPNVISLQ 82
K+G GTY VYK + K + ALK+I G +A RE++LL++LKH N+++L
Sbjct: 197 KLGEGTYATVYKGRSK--LTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLH 254
Query: 83 KVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYL 142
+ H D+ + L+F+Y + DL K + N + VK LYQIL G+ Y
Sbjct: 255 DIV--HTDKSLTLVFEYLDKDL----KQYMDDCGNIMSMH----NVKLFLYQILRGLAYC 304
Query: 143 HANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAP 202
H VLHRDLKP N+L+ E+G +K+AD G AR + P K ++ VVT WYR P
Sbjct: 305 HRRKVLHRDLKPQNLLIN----EKGELKLADFGLARAKSVPTKTYSN---EVVTLWYRPP 357
Query: 203 ELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFP 262
++LLG+ Y+ ID+W +GCIF E+ + P+F D+L IF ++G P
Sbjct: 358 DVLLGSSEYSTQIDMWGVGCIFFEMASGRPLF---------PGSTVEDELHLIFRLLGTP 408
Query: 263 ADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIK 322
+ + W I E K++ Y LI H + DS+ L+ K L + K
Sbjct: 409 SQETWPGISSNEE----FKNYNFPKYKPQPLI----NHAPRLDSEGIELITKFLQYESKK 460
Query: 323 RITSEQAMQDPYFLE-----DPLPTS-DVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQ 375
R+++E+AM+ YF LP S +F+ +I K + G KN++Q
Sbjct: 461 RVSAEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQ 519
>gi|4502735 cyclin-dependent kinase 4 [Homo sapiens]
Length = 303
Score = 169 bits (429), Expect = 4e-42
Identities = 120/326 (36%), Positives = 172/326 (52%), Gaps = 51/326 (15%)
Query: 26 KVGRGTYGHVYKAKRKDGKDDKDYALKQIE-------GTGISMSACREIALLRELK---H 75
++G G YG VYKA+ D ALK + G G+ +S RE+ALLR L+ H
Sbjct: 11 EIGVGAYGTVYKAR--DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68
Query: 76 PNVISLQKVFL-SHADR--KVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLL 132
PNV+ L V S DR KV L+F++ + DL R P LP +K L+
Sbjct: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQDL-------RTYLDKAPPPGLPAETIKDLM 121
Query: 133 YQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDP 192
Q L G+ +LHAN ++HRDLKP NILV G VK+AD G AR+++ + L P
Sbjct: 122 RQFLRGLDFLHANCIVHRDLKPENILV----TSGGTVKLADFGLARIYSYQMA----LTP 173
Query: 193 VVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQL 252
VVVT WYRAPE+LL + Y +D+W++GCIFAE+ +P+F E DQL
Sbjct: 174 VVVTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSE---------ADQL 223
Query: 253 DRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLL 312
+IF+++G P + DW +P + + R S++ ME+ LL
Sbjct: 224 GKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQ----SVVPEMEE-------SGAQLL 272
Query: 313 QKLLTMDPIKRITSEQAMQDPYFLED 338
++LT +P KRI++ +A+Q Y +D
Sbjct: 273 LEMLTFNPHKRISAFRALQHSYLHKD 298
>gi|237858580 cyclin-dependent kinase 10 isoform c [Homo sapiens]
Length = 283
Score = 166 bits (419), Expect = 5e-41
Identities = 104/287 (36%), Positives = 149/287 (51%), Gaps = 38/287 (13%)
Query: 55 EGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRAS 114
E GI +S+ REI LL L+HPN++ L++V + + ++L+ Y E DL AS
Sbjct: 4 EKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDL--------AS 55
Query: 115 KANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADM 174
P VK ++ Q+L G+ YLH N+++HRDLK +N+L+ ++G VK AD
Sbjct: 56 LLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMT----DKGCVKTADF 111
Query: 175 GFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIF 234
G AR + P+KP+ P VVT WYRAPELLLG T +ID+WA+GCI AELL P+
Sbjct: 112 GLARAYGVPVKPMT---PKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPL- 167
Query: 235 HCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLI 294
+ ++ H Q+D I ++G P++ W K+P R+ Y N
Sbjct: 168 ------LPGTSEIH--QIDLIVQLLGTPSENIWPGFSKLP--LVGQYSLRKQPYNNL--- 214
Query: 295 KYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLP 341
KHK S+A L L M T+ ++ YF E PLP
Sbjct: 215 ----KHKFPWLSEAGLRLLHFLFM-----ATAGDCLESSYFKEKPLP 252
>gi|4502747 cyclin-dependent kinase 9 [Homo sapiens]
Length = 372
Score = 165 bits (418), Expect = 7e-41
Identities = 113/345 (32%), Positives = 175/345 (50%), Gaps = 55/345 (15%)
Query: 17 EDLFEYEG-CKVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLR 71
+++ +YE K+G+GT+G V+KA+ + K + ALK++ E G ++A REI +L+
Sbjct: 14 DEVSKYEKLAKIGQGTFGEVFKARHR--KTGQKVALKKVLMENEKEGFPITALREIKILQ 71
Query: 72 ELKHPNVISLQKVFLSHADR------KVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPR 125
LKH NV++L ++ + A ++L+FD+ EHDL A + V+
Sbjct: 72 LLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDL--------AGLLSNVLVKFTL 123
Query: 126 GMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLK 185
+K ++ +L+G++Y+H N +LHRD+K AN+L+ +G +K+AD G AR F+
Sbjct: 124 SEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV----LKLADFGLARAFSLAKN 179
Query: 186 PLAD-LDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTS 244
+ VVT WYR PELLLG R Y ID+W GCI AE+ T PI E
Sbjct: 180 SQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTE----- 234
Query: 245 NPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKP 304
QL I + G + W ++ Y L+K +K KVK
Sbjct: 235 ----QHQLALISQLCGSITPEVWPNVDNY------------ELYEKLELVK-GQKRKVKD 277
Query: 305 DSKAF-------HLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPT 342
KA+ L+ KLL +DP +RI S+ A+ +F DP+P+
Sbjct: 278 RLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPS 322
>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 164 bits (416), Expect = 1e-40
Identities = 113/322 (35%), Positives = 176/322 (54%), Gaps = 51/322 (15%)
Query: 26 KVGRGTYGHVYKAKR-KDGKDDKDYALKQIE----GTGISMSACREIALLRELK---HPN 77
++G G YG V+KA+ K+G + ALK++ G+ +S RE+A+LR L+ HPN
Sbjct: 18 EIGEGAYGKVFKARDLKNG--GRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPN 75
Query: 78 VISLQKVF-LSHADR--KVWLLFDYAEHDLWHIIKFHRASKANKKPVQ-LPRGMVKSLLY 133
V+ L V +S DR K+ L+F++ + DL + +K P +P +K +++
Sbjct: 76 VVRLFDVCTVSRTDRETKLTLVFEHVDQDL--------TTYLDKVPEPGVPTETIKDMMF 127
Query: 134 QILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPV 193
Q+L G+ +LH++ V+HRDLKP NILV G++K+AD G AR+++ + L V
Sbjct: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSS----GQIKLADFGLARIYSFQMA----LTSV 179
Query: 194 VVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLD 253
VVT WYRAPE+LL + Y +D+W++GCIFAE+ +P+F D+ DQL
Sbjct: 180 VVTLWYRAPEVLLQS-SYATPVDLWSVGCIFAEMFRRKPLFR-GSSDV--------DQLG 229
Query: 254 RIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQ 313
+I +V+G P ++DW +P + K + +EK D LL
Sbjct: 230 KILDVIGLPGEEDWPRDVALPRQAFHSKS-----------AQPIEKFVTDIDELGKDLLL 278
Query: 314 KLLTMDPIKRITSEQAMQDPYF 335
K LT +P KRI++ A+ PYF
Sbjct: 279 KCLTFNPAKRISAYSALSHPYF 300
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,533,737
Number of Sequences: 37866
Number of extensions: 1045144
Number of successful extensions: 5835
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 553
Number of HSP's successfully gapped in prelim test: 278
Number of HSP's that attempted gapping in prelim test: 3641
Number of HSP's gapped (non-prelim): 1256
length of query: 464
length of database: 18,247,518
effective HSP length: 106
effective length of query: 358
effective length of database: 14,233,722
effective search space: 5095672476
effective search space used: 5095672476
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.