Search of human proteins with 4502735

Search of human proteins with 4502735

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4502735 cyclin-dependent kinase 4 [Homo sapiens]
         (303 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4502735 cyclin-dependent kinase 4 [Homo sapiens]                   619   e-178
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]                 419   e-117
gi|4502741 cyclin-dependent kinase 6 [Homo sapiens]                   419   e-117
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]                   258   3e-69
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]        243   2e-64
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]             231   5e-61
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]           229   2e-60
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]                   224   1e-58
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]      209   3e-54
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...   206   2e-53
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...   206   2e-53
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...   206   2e-53
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...   206   2e-53
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof...   206   2e-53
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...   206   2e-53
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]    206   2e-53
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]    206   2e-53
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]         204   6e-53
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]         204   6e-53
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]         204   6e-53
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]                   204   1e-52
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]        198   6e-51
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]          198   6e-51
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]                    192   3e-49
gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]                   191   9e-49
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]                   187   8e-48
gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]      183   2e-46
gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens]      183   2e-46
gi|11496279 male germ cell-associated kinase [Homo sapiens]           181   7e-46
gi|27477122 intestinal cell kinase [Homo sapiens]                     180   1e-45

>gi|4502735 cyclin-dependent kinase 4 [Homo sapiens]
          Length = 303

 Score =  619 bits (1597), Expect = e-178
 Identities = 303/303 (100%), Positives = 303/303 (100%)

Query: 1   MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60
           MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
Sbjct: 1   MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60

Query: 61  RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120
           RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
Sbjct: 61  RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120

Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY 180
           MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
Sbjct: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY 180

Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240
           RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
Sbjct: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240

Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG 300
           DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
Sbjct: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG 300

Query: 301 NPE 303
           NPE
Sbjct: 301 NPE 303


>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
          Length = 326

 Score =  419 bits (1077), Expect = e-117
 Identities = 209/294 (71%), Positives = 241/294 (81%), Gaps = 4/294 (1%)

Query: 2   ATSRYEPVAEIGVGAYGTVYKARD-PHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60
           A  +YE VAEIG GAYG V+KARD  + G FVALK VRV  G  G   +P+ST+REVA+L
Sbjct: 9   ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEG---MPLSTIREVAVL 65

Query: 61  RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120
           R LE FEHPNVVRL DVC  SRTDRE K+TLVFEHVDQDL TYLDK P PG+P ETIKD+
Sbjct: 66  RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDM 125

Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY 180
           M Q LRGLDFLH++ +VHRDLKP+NILVTS G +KLADFGLARIYS+QMALT VVVTLWY
Sbjct: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWY 185

Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240
           RAPEVLLQS+YATPVD+WSVGCIFAEMFRRKPLF G+S+ DQLGKI D+IGLP E+DWPR
Sbjct: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245

Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294
           DV+LPR AF  +  +P++  V +++E G  LLL+ LTFNP KRISA+ AL H Y
Sbjct: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299


>gi|4502741 cyclin-dependent kinase 6 [Homo sapiens]
          Length = 326

 Score =  419 bits (1077), Expect = e-117
 Identities = 209/294 (71%), Positives = 241/294 (81%), Gaps = 4/294 (1%)

Query: 2   ATSRYEPVAEIGVGAYGTVYKARD-PHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60
           A  +YE VAEIG GAYG V+KARD  + G FVALK VRV  G  G   +P+ST+REVA+L
Sbjct: 9   ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEG---MPLSTIREVAVL 65

Query: 61  RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120
           R LE FEHPNVVRL DVC  SRTDRE K+TLVFEHVDQDL TYLDK P PG+P ETIKD+
Sbjct: 66  RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDM 125

Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY 180
           M Q LRGLDFLH++ +VHRDLKP+NILVTS G +KLADFGLARIYS+QMALT VVVTLWY
Sbjct: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWY 185

Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240
           RAPEVLLQS+YATPVD+WSVGCIFAEMFRRKPLF G+S+ DQLGKI D+IGLP E+DWPR
Sbjct: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245

Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294
           DV+LPR AF  +  +P++  V +++E G  LLL+ LTFNP KRISA+ AL H Y
Sbjct: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 299


>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
          Length = 305

 Score =  258 bits (660), Expect = 3e-69
 Identities = 137/301 (45%), Positives = 193/301 (64%), Gaps = 15/301 (4%)

Query: 6   YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65
           ++ V +IG G YG VYKA++  +G  VALK +R+     G   +P + +RE++LL+ L+ 
Sbjct: 4   FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEG---VPSTAIREISLLKELK- 59

Query: 66  FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125
             HPN+VRL+DV    R     K+ LVFE + QDL+ Y+D  P   LP   IK  + Q L
Sbjct: 60  --HPNIVRLLDVVHNER-----KLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLL 112

Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPE 184
           +G+ F H++ ++HRDLKP+N+L+   G +KLADFGLAR +   +   T  VVTLWYRAPE
Sbjct: 113 QGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPE 172

Query: 185 VLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243
           +LL S  Y T VD+WS+GCIFAEM  RK LF G+SE DQL +IF ++G P ED WP    
Sbjct: 173 ILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQ 232

Query: 244 LP--RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGN 301
           LP  +G+FP    + ++ +VP +E  G  LL+++L ++P +RI+A  AL H Y    E +
Sbjct: 233 LPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPS 292

Query: 302 P 302
           P
Sbjct: 293 P 293


>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
          Length = 298

 Score =  243 bits (620), Expect = 2e-64
 Identities = 134/293 (45%), Positives = 189/293 (64%), Gaps = 15/293 (5%)

Query: 6   YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65
           ++ V +IG G YG VYKAR+  +G  VALK +R+     G   +P + +RE++LL+ L  
Sbjct: 4   FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEG---VPSTAIREISLLKELN- 59

Query: 66  FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125
             HPN+V+L+DV  T     E K+ LVFE + QDL+ ++D +   G+P   IK  + Q L
Sbjct: 60  --HPNIVKLLDVIHT-----ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLL 112

Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPE 184
           +GL F H++ ++HRDLKP+N+L+ + G +KLADFGLAR +   +   T  VVTLWYRAPE
Sbjct: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172

Query: 185 VLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243
           +LL    Y+T VD+WS+GCIFAEM  R+ LF G+SE DQL +IF  +G P E  WP   S
Sbjct: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232

Query: 244 LP--RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294
           +P  + +FP    +    VVP ++E G  LL +ML ++P+KRISA  AL H +
Sbjct: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285


>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
          Length = 297

 Score =  231 bits (590), Expect = 5e-61
 Identities = 128/296 (43%), Positives = 184/296 (62%), Gaps = 16/296 (5%)

Query: 6   YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65
           Y  + +IG G YG VYK R   +G  VA+K +R+ +   G   +P + +RE++LL+ L  
Sbjct: 4   YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEG---VPSTAIREISLLKELR- 59

Query: 66  FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPG-LPAETIKDLMRQF 124
             HPN+V L DV       ++ ++ L+FE +  DL+ YLD  PP   + +  +K  + Q 
Sbjct: 60  --HPNIVSLQDVLM-----QDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQI 112

Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL-TPVVVTLWYRAP 183
           L+G+ F H+  ++HRDLKP+N+L+   GT+KLADFGLAR +   + + T  VVTLWYR+P
Sbjct: 113 LQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSP 172

Query: 184 EVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242
           EVLL S  Y+TPVD+WS+G IFAE+  +KPLF G+SE DQL +IF  +G P  + WP   
Sbjct: 173 EVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 232

Query: 243 SLP--RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296
           SL   +  FP   P  + S V  ++E+G  LL +ML ++P KRIS   AL H Y +
Sbjct: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288


>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
          Length = 297

 Score =  229 bits (585), Expect = 2e-60
 Identities = 126/296 (42%), Positives = 183/296 (61%), Gaps = 16/296 (5%)

Query: 6   YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65
           Y  + +IG G YG VYK R   +G  VA+K +R+ +   G   +P + +RE++LL+ L  
Sbjct: 4   YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEG---VPSTAIREISLLKELR- 59

Query: 66  FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPG-LPAETIKDLMRQF 124
             HPN+V L DV       ++ ++ L+FE +  DL+ YLD  PP   + +  +K  + Q 
Sbjct: 60  --HPNIVSLQDVLM-----QDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQI 112

Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL-TPVVVTLWYRAP 183
           L+G+ F H+  ++HRDLKP+N+L+   GT+KLADFGLAR +   + + T   +TLWYR+P
Sbjct: 113 LQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSP 172

Query: 184 EVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242
           EVLL S  Y+TPVD+WS+G IFAE+  +KPLF G+SE DQL +IF  +G P  + WP   
Sbjct: 173 EVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 232

Query: 243 SLP--RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296
           SL   +  FP   P  + S V  ++E+G  LL +ML ++P KRIS   AL H Y +
Sbjct: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288


>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
          Length = 292

 Score =  224 bits (570), Expect = 1e-58
 Identities = 131/295 (44%), Positives = 177/295 (60%), Gaps = 17/295 (5%)

Query: 5   RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64
           +YE + +IG G YGTV+KA++  +   VALK VR+ +   G   +P S +RE+ LL+ L+
Sbjct: 3   KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEG---VPSSALREICLLKELK 59

Query: 65  AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124
              H N+VRL DV  + +     K+TLVFE  DQDL+ Y D      L  E +K  + Q 
Sbjct: 60  ---HKNIVRLHDVLHSDK-----KLTLVFEFCDQDLKKYFDSCNGD-LDPEIVKSFLFQL 110

Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAP 183
           L+GL F H+  ++HRDLKP+N+L+   G +KLADFGLAR +   +   +  VVTLWYR P
Sbjct: 111 LKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPP 170

Query: 184 EVLL-QSTYATPVDMWSVGCIFAEMFRR-KPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241
           +VL     Y+T +DMWS GCIFAE+    +PLF GN   DQL +IF L+G P E+ WP  
Sbjct: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM 230

Query: 242 VSLPRGAFPPRGPRPVQ--SVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294
             LP     P  P      +VVP++  +G  LL  +L  NP +RISA  ALQH Y
Sbjct: 231 TKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285


>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
          Length = 360

 Score =  209 bits (531), Expect = 3e-54
 Identities = 124/298 (41%), Positives = 173/298 (58%), Gaps = 15/298 (5%)

Query: 2   ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61
           +   +E +  IG G YG VY+ARD  +   VALK VR+     G   +PIS++RE+ LL 
Sbjct: 35  SVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDG---IPISSLREITLLL 91

Query: 62  RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121
           RL    HPN+V L +V   +  +    + LV  + +QDL + L+  P P   A+ +K ++
Sbjct: 92  RLR---HPNIVELKEVVVGNHLE---SIFLVMGYCEQDLASLLENMPTPFSEAQ-VKCIV 144

Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWY 180
            Q LRGL +LH N I+HRDLK  N+L+T  G VK ADFGLAR Y   +  +TP VVTLWY
Sbjct: 145 LQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWY 204

Query: 181 RAPEVLL-QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239
           RAPE+LL  +T  T +DMW+VGCI AE+   +PL  G SE  Q+  I  L+G P E+ WP
Sbjct: 205 RAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWP 264

Query: 240 RDVSLPRGAFPPRGPRPVQSV---VPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294
               LP         +P  ++    P + E+G +LL  +  ++P KR +A   L+ SY
Sbjct: 265 GFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSY 322


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score =  206 bits (525), Expect = 2e-53
 Identities = 119/302 (39%), Positives = 175/302 (57%), Gaps = 16/302 (5%)

Query: 2   ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61
           +   ++ +  I  G YG VY+A+D  +   VALK +++     G    PI+++RE+  + 
Sbjct: 410 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG---FPITSLREINTIL 466

Query: 62  RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121
           + +   HPN+V + ++   S  D   K+ +V  +V+ DL++ ++    P LP E +K LM
Sbjct: 467 KAQ---HPNIVTVREIVVGSNMD---KIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLM 519

Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWY 180
            Q LRG+  LH N I+HRDLK  N+L++  G +K+ DFGLAR Y   + A TPVVVTLWY
Sbjct: 520 IQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWY 579

Query: 181 RAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239
           RAPE+LL +  Y+T VDMWSVGCIF E+  +KPLF G SE DQ+ K+F  +G P E  WP
Sbjct: 580 RAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWP 639

Query: 240 RDVSLPRGAFPPRGPRPVQSVVPE----MEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295
               LP          P  ++       + + G  L+ + LT+ P +RISA   L+H Y 
Sbjct: 640 GYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 699

Query: 296 HK 297
            +
Sbjct: 700 RE 701


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score =  206 bits (525), Expect = 2e-53
 Identities = 119/302 (39%), Positives = 175/302 (57%), Gaps = 16/302 (5%)

Query: 2   ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61
           +   ++ +  I  G YG VY+A+D  +   VALK +++     G    PI+++RE+  + 
Sbjct: 419 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG---FPITSLREINTIL 475

Query: 62  RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121
           + +   HPN+V + ++   S  D   K+ +V  +V+ DL++ ++    P LP E +K LM
Sbjct: 476 KAQ---HPNIVTVREIVVGSNMD---KIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLM 528

Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWY 180
            Q LRG+  LH N I+HRDLK  N+L++  G +K+ DFGLAR Y   + A TPVVVTLWY
Sbjct: 529 IQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWY 588

Query: 181 RAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239
           RAPE+LL +  Y+T VDMWSVGCIF E+  +KPLF G SE DQ+ K+F  +G P E  WP
Sbjct: 589 RAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWP 648

Query: 240 RDVSLPRGAFPPRGPRPVQSVVPE----MEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295
               LP          P  ++       + + G  L+ + LT+ P +RISA   L+H Y 
Sbjct: 649 GYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 708

Query: 296 HK 297
            +
Sbjct: 709 RE 710


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score =  206 bits (525), Expect = 2e-53
 Identities = 119/302 (39%), Positives = 175/302 (57%), Gaps = 16/302 (5%)

Query: 2   ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61
           +   ++ +  I  G YG VY+A+D  +   VALK +++     G    PI+++RE+  + 
Sbjct: 387 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG---FPITSLREINTIL 443

Query: 62  RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121
           + +   HPN+V + ++   S  D   K+ +V  +V+ DL++ ++    P LP E +K LM
Sbjct: 444 KAQ---HPNIVTVREIVVGSNMD---KIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLM 496

Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWY 180
            Q LRG+  LH N I+HRDLK  N+L++  G +K+ DFGLAR Y   + A TPVVVTLWY
Sbjct: 497 IQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWY 556

Query: 181 RAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239
           RAPE+LL +  Y+T VDMWSVGCIF E+  +KPLF G SE DQ+ K+F  +G P E  WP
Sbjct: 557 RAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWP 616

Query: 240 RDVSLPRGAFPPRGPRPVQSVVPE----MEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295
               LP          P  ++       + + G  L+ + LT+ P +RISA   L+H Y 
Sbjct: 617 GYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 676

Query: 296 HK 297
            +
Sbjct: 677 RE 678


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score =  206 bits (525), Expect = 2e-53
 Identities = 119/302 (39%), Positives = 175/302 (57%), Gaps = 16/302 (5%)

Query: 2   ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61
           +   ++ +  I  G YG VY+A+D  +   VALK +++     G    PI+++RE+  + 
Sbjct: 376 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG---FPITSLREINTIL 432

Query: 62  RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121
           + +   HPN+V + ++   S  D   K+ +V  +V+ DL++ ++    P LP E +K LM
Sbjct: 433 KAQ---HPNIVTVREIVVGSNMD---KIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLM 485

Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWY 180
            Q LRG+  LH N I+HRDLK  N+L++  G +K+ DFGLAR Y   + A TPVVVTLWY
Sbjct: 486 IQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWY 545

Query: 181 RAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239
           RAPE+LL +  Y+T VDMWSVGCIF E+  +KPLF G SE DQ+ K+F  +G P E  WP
Sbjct: 546 RAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWP 605

Query: 240 RDVSLPRGAFPPRGPRPVQSVVPE----MEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295
               LP          P  ++       + + G  L+ + LT+ P +RISA   L+H Y 
Sbjct: 606 GYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 665

Query: 296 HK 297
            +
Sbjct: 666 RE 667


>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           3 [Homo sapiens]
          Length = 526

 Score =  206 bits (525), Expect = 2e-53
 Identities = 119/302 (39%), Positives = 175/302 (57%), Gaps = 16/302 (5%)

Query: 2   ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61
           +   ++ +  I  G YG VY+A+D  +   VALK +++     G    PI+++RE+  + 
Sbjct: 165 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG---FPITSLREINTIL 221

Query: 62  RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121
           + +   HPN+V + ++   S  D   K+ +V  +V+ DL++ ++    P LP E +K LM
Sbjct: 222 KAQ---HPNIVTVREIVVGSNMD---KIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLM 274

Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWY 180
            Q LRG+  LH N I+HRDLK  N+L++  G +K+ DFGLAR Y   + A TPVVVTLWY
Sbjct: 275 IQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWY 334

Query: 181 RAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239
           RAPE+LL +  Y+T VDMWSVGCIF E+  +KPLF G SE DQ+ K+F  +G P E  WP
Sbjct: 335 RAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWP 394

Query: 240 RDVSLPRGAFPPRGPRPVQSVVPE----MEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295
               LP          P  ++       + + G  L+ + LT+ P +RISA   L+H Y 
Sbjct: 395 GYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 454

Query: 296 HK 297
            +
Sbjct: 455 RE 456


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score =  206 bits (525), Expect = 2e-53
 Identities = 119/302 (39%), Positives = 175/302 (57%), Gaps = 16/302 (5%)

Query: 2   ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61
           +   ++ +  I  G YG VY+A+D  +   VALK +++     G    PI+++RE+  + 
Sbjct: 421 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG---FPITSLREINTIL 477

Query: 62  RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121
           + +   HPN+V + ++   S  D   K+ +V  +V+ DL++ ++    P LP E +K LM
Sbjct: 478 KAQ---HPNIVTVREIVVGSNMD---KIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLM 530

Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWY 180
            Q LRG+  LH N I+HRDLK  N+L++  G +K+ DFGLAR Y   + A TPVVVTLWY
Sbjct: 531 IQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWY 590

Query: 181 RAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239
           RAPE+LL +  Y+T VDMWSVGCIF E+  +KPLF G SE DQ+ K+F  +G P E  WP
Sbjct: 591 RAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWP 650

Query: 240 RDVSLPRGAFPPRGPRPVQSVVPE----MEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295
               LP          P  ++       + + G  L+ + LT+ P +RISA   L+H Y 
Sbjct: 651 GYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 710

Query: 296 HK 297
            +
Sbjct: 711 RE 712


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score =  206 bits (524), Expect = 2e-53
 Identities = 119/302 (39%), Positives = 175/302 (57%), Gaps = 16/302 (5%)

Query: 2   ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61
           +   ++ +  I  G YG VY+A+D  +   VALK +++     G    PI+++RE+  + 
Sbjct: 409 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG---FPITSLREINTIL 465

Query: 62  RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121
           + +   HPN+V + ++   S  D   K+ +V  +V+ DL++ ++    P LP E +K LM
Sbjct: 466 KAQ---HPNIVTVREIVVGSNMD---KIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLM 518

Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWY 180
            Q LRG+  LH N I+HRDLK  N+L++  G +K+ DFGLAR Y   + A TPVVVT WY
Sbjct: 519 IQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWY 578

Query: 181 RAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239
           RAPE+LL +  Y+T VDMWSVGCIF E+  +KPLF GNSE DQ+ K+F  +G P E  WP
Sbjct: 579 RAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWP 638

Query: 240 RDVSLPRGAFPPRGPRPVQSVVPE----MEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295
               LP          P  ++       + + G  L+ + LT+ P +RISA   L+H Y 
Sbjct: 639 GYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 698

Query: 296 HK 297
            +
Sbjct: 699 RE 700


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score =  206 bits (524), Expect = 2e-53
 Identities = 119/302 (39%), Positives = 175/302 (57%), Gaps = 16/302 (5%)

Query: 2   ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61
           +   ++ +  I  G YG VY+A+D  +   VALK +++     G    PI+++RE+  + 
Sbjct: 419 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG---FPITSLREINTIL 475

Query: 62  RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121
           + +   HPN+V + ++   S  D   K+ +V  +V+ DL++ ++    P LP E +K LM
Sbjct: 476 KAQ---HPNIVTVREIVVGSNMD---KIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLM 528

Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWY 180
            Q LRG+  LH N I+HRDLK  N+L++  G +K+ DFGLAR Y   + A TPVVVT WY
Sbjct: 529 IQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWY 588

Query: 181 RAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239
           RAPE+LL +  Y+T VDMWSVGCIF E+  +KPLF GNSE DQ+ K+F  +G P E  WP
Sbjct: 589 RAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWP 648

Query: 240 RDVSLPRGAFPPRGPRPVQSVVPE----MEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295
               LP          P  ++       + + G  L+ + LT+ P +RISA   L+H Y 
Sbjct: 649 GYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 708

Query: 296 HK 297
            +
Sbjct: 709 RE 710


>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
          Length = 504

 Score =  204 bits (520), Expect = 6e-53
 Identities = 122/294 (41%), Positives = 172/294 (58%), Gaps = 18/294 (6%)

Query: 6   YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65
           Y  + ++G G Y TV+K R   + + VALK +R+ +  G     P + +REV+LL+ L+ 
Sbjct: 174 YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGA----PCTAIREVSLLKNLK- 228

Query: 66  FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125
             H N+V L D+  T R+     +TLVFE++D DL+ YLD      +    +K  M Q L
Sbjct: 229 --HANIVTLHDLIHTDRS-----LTLVFEYLDSDLKQYLDHCGNL-MSMHNVKIFMFQLL 280

Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPE 184
           RGL + H   I+HRDLKP+N+L+   G +KLADFGLAR  S      +  VVTLWYR P+
Sbjct: 281 RGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPD 340

Query: 185 VLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243
           VLL ST Y+TP+DMW VGCI  EM   +PLF G++  ++L  IF L+G P E+ WP   +
Sbjct: 341 VLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTA 400

Query: 244 LPR---GAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294
                  +FP   P+P+ +  P ++  G  LL  +L +    R+SA  AL HSY
Sbjct: 401 FSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSY 454


>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
          Length = 474

 Score =  204 bits (520), Expect = 6e-53
 Identities = 122/294 (41%), Positives = 172/294 (58%), Gaps = 18/294 (6%)

Query: 6   YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65
           Y  + ++G G Y TV+K R   + + VALK +R+ +  G     P + +REV+LL+ L+ 
Sbjct: 144 YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGA----PCTAIREVSLLKNLK- 198

Query: 66  FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125
             H N+V L D+  T R+     +TLVFE++D DL+ YLD      +    +K  M Q L
Sbjct: 199 --HANIVTLHDLIHTDRS-----LTLVFEYLDSDLKQYLDHCGNL-MSMHNVKIFMFQLL 250

Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPE 184
           RGL + H   I+HRDLKP+N+L+   G +KLADFGLAR  S      +  VVTLWYR P+
Sbjct: 251 RGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPD 310

Query: 185 VLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243
           VLL ST Y+TP+DMW VGCI  EM   +PLF G++  ++L  IF L+G P E+ WP   +
Sbjct: 311 VLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTA 370

Query: 244 LPR---GAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294
                  +FP   P+P+ +  P ++  G  LL  +L +    R+SA  AL HSY
Sbjct: 371 FSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSY 424


>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
          Length = 474

 Score =  204 bits (520), Expect = 6e-53
 Identities = 122/294 (41%), Positives = 172/294 (58%), Gaps = 18/294 (6%)

Query: 6   YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65
           Y  + ++G G Y TV+K R   + + VALK +R+ +  G     P + +REV+LL+ L+ 
Sbjct: 144 YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGA----PCTAIREVSLLKNLK- 198

Query: 66  FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125
             H N+V L D+  T R+     +TLVFE++D DL+ YLD      +    +K  M Q L
Sbjct: 199 --HANIVTLHDLIHTDRS-----LTLVFEYLDSDLKQYLDHCGNL-MSMHNVKIFMFQLL 250

Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPE 184
           RGL + H   I+HRDLKP+N+L+   G +KLADFGLAR  S      +  VVTLWYR P+
Sbjct: 251 RGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPD 310

Query: 185 VLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243
           VLL ST Y+TP+DMW VGCI  EM   +PLF G++  ++L  IF L+G P E+ WP   +
Sbjct: 311 VLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTA 370

Query: 244 LPR---GAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294
                  +FP   P+P+ +  P ++  G  LL  +L +    R+SA  AL HSY
Sbjct: 371 FSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSY 424


>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
          Length = 523

 Score =  204 bits (518), Expect = 1e-52
 Identities = 116/294 (39%), Positives = 174/294 (59%), Gaps = 18/294 (6%)

Query: 6   YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65
           Y  + ++G G Y TVYK R   + + VALK +R+ +  G     P + +REV+LL+ L+ 
Sbjct: 192 YIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGA----PCTAIREVSLLKDLK- 246

Query: 66  FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125
             H N+V L D+  T ++     +TLVFE++D+DL+ Y+D      +    +K  + Q L
Sbjct: 247 --HANIVTLHDIVHTDKS-----LTLVFEYLDKDLKQYMDDCGNI-MSMHNVKLFLYQIL 298

Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPE 184
           RGL + H   ++HRDLKP+N+L+   G +KLADFGLAR  S      +  VVTLWYR P+
Sbjct: 299 RGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPD 358

Query: 185 VLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP---R 240
           VLL S+ Y+T +DMW VGCIF EM   +PLF G++  D+L  IF L+G P ++ WP    
Sbjct: 359 VLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISS 418

Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294
           +       FP   P+P+ +  P ++  G +L+ + L +   KR+SA  A++H Y
Sbjct: 419 NEEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVY 472


>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
          Length = 502

 Score =  198 bits (503), Expect = 6e-51
 Identities = 117/294 (39%), Positives = 172/294 (58%), Gaps = 18/294 (6%)

Query: 6   YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65
           Y  + ++G G Y TVYK +   + + VALK +R+ +  G     P + +REV+LL+ L+ 
Sbjct: 171 YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGA----PCTAIREVSLLKDLK- 225

Query: 66  FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125
             H N+V L D+  T ++     +TLVFE++D+DL+ YLD      +    +K  + Q L
Sbjct: 226 --HANIVTLHDIIHTEKS-----LTLVFEYLDKDLKQYLDDCGNI-INMHNVKLFLFQLL 277

Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPE 184
           RGL + H   ++HRDLKP+N+L+   G +KLADFGLAR  S      +  VVTLWYR P+
Sbjct: 278 RGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPD 337

Query: 185 VLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243
           +LL ST Y+T +DMW VGCIF EM   +PLF G++  +QL  IF ++G P E+ WP  +S
Sbjct: 338 ILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILS 397

Query: 244 ---LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294
                   +P      + S  P ++  GA LL ++L F    RISA  A++H +
Sbjct: 398 NEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPF 451


>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
          Length = 496

 Score =  198 bits (503), Expect = 6e-51
 Identities = 117/294 (39%), Positives = 172/294 (58%), Gaps = 18/294 (6%)

Query: 6   YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65
           Y  + ++G G Y TVYK +   + + VALK +R+ +  G     P + +REV+LL+ L+ 
Sbjct: 165 YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGA----PCTAIREVSLLKDLK- 219

Query: 66  FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125
             H N+V L D+  T ++     +TLVFE++D+DL+ YLD      +    +K  + Q L
Sbjct: 220 --HANIVTLHDIIHTEKS-----LTLVFEYLDKDLKQYLDDCGNI-INMHNVKLFLFQLL 271

Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPE 184
           RGL + H   ++HRDLKP+N+L+   G +KLADFGLAR  S      +  VVTLWYR P+
Sbjct: 272 RGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPD 331

Query: 185 VLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243
           +LL ST Y+T +DMW VGCIF EM   +PLF G++  +QL  IF ++G P E+ WP  +S
Sbjct: 332 ILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILS 391

Query: 244 ---LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294
                   +P      + S  P ++  GA LL ++L F    RISA  A++H +
Sbjct: 392 NEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPF 445


>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
          Length = 451

 Score =  192 bits (488), Expect = 3e-49
 Identities = 122/298 (40%), Positives = 170/298 (57%), Gaps = 23/298 (7%)

Query: 6   YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65
           YE + ++G G+Y TVYK +   +G  VALK +R+    G     P + +RE +LL+ L+ 
Sbjct: 117 YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEG----TPFTAIREASLLKGLK- 171

Query: 66  FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125
             H N+V L D+  T  T     +TLVFE+V  DL  Y+DK P  GL  + +K  + Q L
Sbjct: 172 --HANIVLLHDIIHTKET-----LTLVFEYVHTDLCQYMDKHPG-GLHPDNVKLFLFQLL 223

Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY-QMALTPVVVTLWYRAPE 184
           RGL ++H   I+HRDLKP+N+L++  G +KLADFGLAR  S      +  VVTLWYR P+
Sbjct: 224 RGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPD 283

Query: 185 VLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSE-ADQLGKIFDLIGLPPEDDWPRDV 242
           VLL ST Y+T +DMW VGCIF EM +    F G  +  DQL +IF ++G P ED WP   
Sbjct: 284 VLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVH 343

Query: 243 SLPR------GAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294
           SLP         +  +  R   + +  +  +   L  ++L  +P  R+SA  AL H Y
Sbjct: 344 SLPHFKPERFTLYSSKNLRQAWNKLSYVNHA-EDLASKLLQCSPKNRLSAQAALSHEY 400


>gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]
          Length = 384

 Score =  191 bits (484), Expect = 9e-49
 Identities = 123/305 (40%), Positives = 173/305 (56%), Gaps = 29/305 (9%)

Query: 2   ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61
           A S Y  + ++G G+Y TVYK     +G  VALK + +        G+P + +RE +LL+
Sbjct: 48  AASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISM----NAEEGVPFTAIREASLLK 103

Query: 62  RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121
            L+   H N+V L D+  T  T     +T VFE++  DL  Y+ + P  GL    ++  M
Sbjct: 104 GLK---HANIVLLHDIIHTKET-----LTFVFEYMHTDLAQYMSQHPG-GLHPHNVRLFM 154

Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY-QMALTPVVVTLWY 180
            Q LRGL ++H   ++HRDLKP+N+L++  G +KLADFGLAR  S      +  VVTLWY
Sbjct: 155 FQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWY 214

Query: 181 RAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSE-ADQLGKIFDLIGLPPEDDW 238
           R P+ LL +T Y++ +D+W  GCIF EMF+ +PLF G S   +QL KI++++G+P ED W
Sbjct: 215 RPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTW 274

Query: 239 PRDVSLPR---GAFPPRGPRPVQSV------VPEMEESGAQLLLEMLTFNPHKRISAFRA 289
           P    LP      FP   PR +  V      VPE E+  +Q    ML   P  R+SA  A
Sbjct: 275 PGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQ----MLKGFPRDRVSAQEA 330

Query: 290 LQHSY 294
           L H Y
Sbjct: 331 LVHDY 335


>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
          Length = 346

 Score =  187 bits (476), Expect = 8e-48
 Identities = 113/299 (37%), Positives = 166/299 (55%), Gaps = 12/299 (4%)

Query: 5   RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64
           RYE +  +G G + TVYKARD ++   VA+K +++ +      G+  + +RE+ LL+ L 
Sbjct: 11  RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70

Query: 65  AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124
              HPN++ L+D         +  ++LVF+ ++ DL   + K     L    IK  M   
Sbjct: 71  ---HPNIIGLLDAFG-----HKSNISLVFDFMETDLEVII-KDNSLVLTPSHIKAYMLMT 121

Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-SYQMALTPVVVTLWYRAP 183
           L+GL++LH + I+HRDLKP N+L+   G +KLADFGLA+ + S   A T  VVT WYRAP
Sbjct: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAP 181

Query: 184 EVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242
           E+L  +  Y   VDMW+VGCI AE+  R P   G+S+ DQL +IF+ +G P E+ WP   
Sbjct: 182 ELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMC 241

Query: 243 SLP-RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG 300
           SLP    F      P+  +     +    L+  +  FNP  RI+A +AL+  Y     G
Sbjct: 242 SLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300


>gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]
          Length = 289

 Score =  183 bits (464), Expect = 2e-46
 Identities = 107/252 (42%), Positives = 150/252 (59%), Gaps = 12/252 (4%)

Query: 48  GLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKA 107
           G+PIS++RE+ LL RL    HPN+V L +V   +  +    + LV  + +QDL + L+  
Sbjct: 7   GIPISSLREITLLLRLR---HPNIVELKEVVVGNHLE---SIFLVMGYCEQDLASLLENM 60

Query: 108 PPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY 167
           P P   A+ +K ++ Q LRGL +LH N I+HRDLK  N+L+T  G VK ADFGLAR Y  
Sbjct: 61  PTPFSEAQ-VKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGV 119

Query: 168 QM-ALTPVVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGK 225
            +  +TP VVTLWYRAPE+LL  +T  T +DMW+VGCI AE+   +PL  G SE  Q+  
Sbjct: 120 PVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDL 179

Query: 226 IFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSV---VPEMEESGAQLLLEMLTFNPHK 282
           I  L+G P E+ WP    LP         +P  ++    P + E+G +LL  +  ++P K
Sbjct: 180 IVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKK 239

Query: 283 RISAFRALQHSY 294
           R +A   L+ SY
Sbjct: 240 RATAGDCLESSY 251


>gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens]
          Length = 272

 Score =  183 bits (464), Expect = 2e-46
 Identities = 107/252 (42%), Positives = 150/252 (59%), Gaps = 12/252 (4%)

Query: 48  GLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKA 107
           G+PIS++RE+ LL RL    HPN+V L +V   +  +    + LV  + +QDL + L+  
Sbjct: 7   GIPISSLREITLLLRLR---HPNIVELKEVVVGNHLE---SIFLVMGYCEQDLASLLENM 60

Query: 108 PPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY 167
           P P   A+ +K ++ Q LRGL +LH N I+HRDLK  N+L+T  G VK ADFGLAR Y  
Sbjct: 61  PTPFSEAQ-VKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGV 119

Query: 168 QM-ALTPVVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGK 225
            +  +TP VVTLWYRAPE+LL  +T  T +DMW+VGCI AE+   +PL  G SE  Q+  
Sbjct: 120 PVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDL 179

Query: 226 IFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSV---VPEMEESGAQLLLEMLTFNPHK 282
           I  L+G P E+ WP    LP         +P  ++    P + E+G +LL  +  ++P K
Sbjct: 180 IVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKK 239

Query: 283 RISAFRALQHSY 294
           R +A   L+ SY
Sbjct: 240 RATAGDCLESSY 251


>gi|11496279 male germ cell-associated kinase [Homo sapiens]
          Length = 623

 Score =  181 bits (459), Expect = 7e-46
 Identities = 107/295 (36%), Positives = 165/295 (55%), Gaps = 17/295 (5%)

Query: 4   SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63
           +RY  + ++G G YG+V   +   SG  VA+K ++               +REV  L++L
Sbjct: 2   NRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWD----ECMNLREVKSLKKL 57

Query: 64  EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123
               H NV++L +V   +       +  +FE++ ++L   + K      P   I+++M Q
Sbjct: 58  N---HANVIKLKEVIREND-----HLYFIFEYMKENLYQLM-KDRNKLFPESVIRNIMYQ 108

Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAP 183
            L+GL F+H +   HRD+KPEN+L      VK+ADFGLAR    Q   T  V T WYRAP
Sbjct: 109 ILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAP 168

Query: 184 EVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242
           EVLL+S+ Y++P+D+W+VG I AE++  +PLF G SE D++ KI  ++G P + DWP   
Sbjct: 169 EVLLRSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGY 228

Query: 243 SLPRG---AFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294
            L       FP   P  +++++P       QL+ EML ++P KR +A +AL+H Y
Sbjct: 229 QLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPY 283


>gi|27477122 intestinal cell kinase [Homo sapiens]
          Length = 632

 Score =  180 bits (457), Expect = 1e-45
 Identities = 108/295 (36%), Positives = 165/295 (55%), Gaps = 17/295 (5%)

Query: 4   SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63
           +RY  + ++G G YG+V   R   SG  +A+K ++               +REV  L++L
Sbjct: 2   NRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWE----ECMNLREVKSLKKL 57

Query: 64  EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123
               H NVV+L +V   +       +  +FE++ ++L   + K      P   I+++M Q
Sbjct: 58  N---HANVVKLKEVIREND-----HLYFIFEYMKENLYQLI-KERNKLFPESAIRNIMYQ 108

Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAP 183
            L+GL F+H +   HRDLKPEN+L      VK+ADFGLAR    +   T  V T WYRAP
Sbjct: 109 ILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRAP 168

Query: 184 EVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242
           EVLL+ST Y++P+D+W+VGCI AE++  +PLF G SE D + KI  ++G P + DWP   
Sbjct: 169 EVLLRSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGY 228

Query: 243 SLPRG---AFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294
            L       +P   P  +++++P       QLL +ML ++P KR +A +AL++ Y
Sbjct: 229 QLSSAMNFRWPQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPY 283


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.140    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,959,663
Number of Sequences: 37866
Number of extensions: 633491
Number of successful extensions: 4872
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 744
Number of HSP's successfully gapped in prelim test: 59
Number of HSP's that attempted gapping in prelim test: 2607
Number of HSP's gapped (non-prelim): 1039
length of query: 303
length of database: 18,247,518
effective HSP length: 102
effective length of query: 201
effective length of database: 14,385,186
effective search space: 2891422386
effective search space used: 2891422386
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.