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Search of human proteins with 4501913
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
sapiens]
(832 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s... 1758 0.0
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot... 754 0.0
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot... 754 0.0
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot... 754 0.0
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot... 754 0.0
gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprote... 754 0.0
gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo s... 753 0.0
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ... 361 1e-99
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot... 354 2e-97
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot... 354 2e-97
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H... 334 2e-91
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro... 318 2e-86
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop... 296 4e-80
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor... 295 1e-79
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor... 295 1e-79
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor... 295 1e-79
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor... 295 1e-79
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor... 295 1e-79
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor... 295 1e-79
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ... 293 3e-79
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot... 293 6e-79
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ... 274 3e-73
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ... 273 4e-73
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens] 270 5e-72
gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo sapi... 265 1e-70
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo... 260 4e-69
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo... 260 4e-69
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo... 260 4e-69
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ... 260 4e-69
gi|148664238 a disintegrin and metalloprotease domain 32 [Homo s... 258 2e-68
>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
sapiens]
Length = 832
Score = 1758 bits (4553), Expect = 0.0
Identities = 832/832 (100%), Positives = 832/832 (100%)
Query: 1 MKPPGSSSRQPPLAGCSLAGASCGPQRGPAGSVPASAPARTPPCRLLLVLLLLPPLAASS 60
MKPPGSSSRQPPLAGCSLAGASCGPQRGPAGSVPASAPARTPPCRLLLVLLLLPPLAASS
Sbjct: 1 MKPPGSSSRQPPLAGCSLAGASCGPQRGPAGSVPASAPARTPPCRLLLVLLLLPPLAASS 60
Query: 61 RPRAWGAAAPSAPHWNETAEKNLGVLADEDNTLQQNSSSNISYSNAMQKEITLPSRLIYY 120
RPRAWGAAAPSAPHWNETAEKNLGVLADEDNTLQQNSSSNISYSNAMQKEITLPSRLIYY
Sbjct: 61 RPRAWGAAAPSAPHWNETAEKNLGVLADEDNTLQQNSSSNISYSNAMQKEITLPSRLIYY 120
Query: 121 INQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILNNGLLSSDYVEI 180
INQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILNNGLLSSDYVEI
Sbjct: 121 INQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILNNGLLSSDYVEI 180
Query: 181 HYENGKPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDE 240
HYENGKPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDE
Sbjct: 181 HYENGKPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDE 240
Query: 241 KSTGRPHIIQKTLAGQYSKQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKY 300
KSTGRPHIIQKTLAGQYSKQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKY
Sbjct: 241 KSTGRPHIIQKTLAGQYSKQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKY 300
Query: 301 LELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQID 360
LELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQID
Sbjct: 301 LELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQID 360
Query: 361 ITTNPVQMLHEFSKYRQRIKQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYG 420
ITTNPVQMLHEFSKYRQRIKQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYG
Sbjct: 361 ITTNPVQMLHEFSKYRQRIKQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYG 420
Query: 421 LPMAVAQVLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEY 480
LPMAVAQVLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEY
Sbjct: 421 LPMAVAQVLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEY 480
Query: 481 RDFLQRGGGACLFNRPTKLFEPTECGNGYVEAGEECDCGFHVECYGLCCKKCSLSNGAHC 540
RDFLQRGGGACLFNRPTKLFEPTECGNGYVEAGEECDCGFHVECYGLCCKKCSLSNGAHC
Sbjct: 481 RDFLQRGGGACLFNRPTKLFEPTECGNGYVEAGEECDCGFHVECYGLCCKKCSLSNGAHC 540
Query: 541 SDGPCCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCY 600
SDGPCCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCY
Sbjct: 541 SDGPCCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCY 600
Query: 601 NGECKTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFL 660
NGECKTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFL
Sbjct: 601 NGECKTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFL 660
Query: 661 LCTNLTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVEDGTPCGPSMMC 720
LCTNLTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVEDGTPCGPSMMC
Sbjct: 661 LCTNLTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVEDGTPCGPSMMC 720
Query: 721 LDRKCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIRDPVRNLHPP 780
LDRKCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIRDPVRNLHPP
Sbjct: 721 LDRKCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIRDPVRNLHPP 780
Query: 781 KDEGPKGPSATNLIIGSIAGAILVAAIVLGGTGWGFKNVKKRRFDPTQQGPI 832
KDEGPKGPSATNLIIGSIAGAILVAAIVLGGTGWGFKNVKKRRFDPTQQGPI
Sbjct: 781 KDEGPKGPSATNLIIGSIAGAILVAAIVLGGTGWGFKNVKKRRFDPTQQGPI 832
>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
[Homo sapiens]
Length = 906
Score = 754 bits (1948), Expect = 0.0
Identities = 372/742 (50%), Positives = 489/742 (65%), Gaps = 44/742 (5%)
Query: 107 MQKEITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDL 166
++++ +P RLIY + ES + LDT+ R + H+ QASFQ++AFG+ FILD+
Sbjct: 45 VERQSIVPLRLIYRSGGEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDV 104
Query: 167 ILNNGLLSSDYVEIHYENG-KPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDD 225
+LN+ LLSS+Y+E H E+G K KGGEHCYY G IRG DS VALSTC+GLHGMF D
Sbjct: 105 VLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDG 164
Query: 226 TFVYMIEPLELVHDEKSTGRP----HIIQKTLAGQYSK-------QMKNLTMERGDQWPF 274
Y+IEP +E T + H + K+ ++S Q N+T + F
Sbjct: 165 NHTYLIEP-----EENDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSK-----F 214
Query: 275 LSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVD 334
+ + + + +++ R + EE KY+ELMIVNDH +KKHR S HTN +AKSVVN+ D
Sbjct: 215 ILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMAD 274
Query: 335 SIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQR-IKQHADAVHLISRVT 393
IYK+QL TR+VLVA+ETW ++ I+ NP+ L EF KYR+ IK+ +DAVHL S
Sbjct: 275 LIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQ 334
Query: 394 FHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSS-RKPKCDC 452
F RS +Y GG+CS +G GVNE+G +A L+QSLA N+GI + +C C
Sbjct: 335 FESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKC 394
Query: 453 TESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKLFEPTECGNGYVEA 512
++W GCIM +TG +KF++C+I EY DFL GGGACLFN+P+KL +P ECGNG++E
Sbjct: 395 EDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIET 454
Query: 513 GEECDCGFHVECY---GLCCKKCSLSNGAHCSDGPCCNNTSCLFQPRGYECRDAVNECDI 569
GEECDCG EC CCKKC+L+ + CSDG CC C FQP G CR+AVN+CDI
Sbjct: 455 GEECDCGTPAECVLEGAECCKKCTLTQDSQCSDGLCCKK--CKFQPMGTVCREAVNDCDI 512
Query: 570 TEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYIWGTKAAGSDKFCYEK 629
E C+G+S QC PN+HK DGY+C+ QG C+ G CKTRD QC+YIWG K SDK+CYEK
Sbjct: 513 RETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEK 572
Query: 630 LNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFYHQGRV 689
LN EGTEKGNCGKD D WIQC+K DV CG+LLCTN+ PR+G+L GEI T QGR
Sbjct: 573 LNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRT 632
Query: 690 IDCSGAHVVLDDDTDVGYVEDGTPCGPSMMCLDRKCLQIQALNMSSCPLDSKGKVCSGHG 749
++CSG HV L++D D+GYVEDGTPCGP MMCL+ +CL + + N S+C +G +CSG+G
Sbjct: 633 LNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNG 692
Query: 750 VCSNEATCICDFTWAGTDCSIRDPVRNLHPPKDEGPK--------GPSATNLIIGSIAGA 801
VCSNE C+C+ W G+DC N + P ++ K G + TN+IIG IAG
Sbjct: 693 VCSNELKCVCNRHWIGSDC-------NTYFPHNDDAKTGITLSGNGVAGTNIIIGIIAGT 745
Query: 802 ILVAAIVLGGTGWGFKNVKKRR 823
ILV A++LG T WG+KN +++R
Sbjct: 746 ILVLALILGITAWGYKNYREQR 767
>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
[Homo sapiens]
Length = 899
Score = 754 bits (1948), Expect = 0.0
Identities = 372/742 (50%), Positives = 489/742 (65%), Gaps = 44/742 (5%)
Query: 107 MQKEITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDL 166
++++ +P RLIY + ES + LDT+ R + H+ QASFQ++AFG+ FILD+
Sbjct: 45 VERQSIVPLRLIYRSGGEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDV 104
Query: 167 ILNNGLLSSDYVEIHYENG-KPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDD 225
+LN+ LLSS+Y+E H E+G K KGGEHCYY G IRG DS VALSTC+GLHGMF D
Sbjct: 105 VLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDG 164
Query: 226 TFVYMIEPLELVHDEKSTGRP----HIIQKTLAGQYSK-------QMKNLTMERGDQWPF 274
Y+IEP +E T + H + K+ ++S Q N+T + F
Sbjct: 165 NHTYLIEP-----EENDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSK-----F 214
Query: 275 LSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVD 334
+ + + + +++ R + EE KY+ELMIVNDH +KKHR S HTN +AKSVVN+ D
Sbjct: 215 ILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMAD 274
Query: 335 SIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQR-IKQHADAVHLISRVT 393
IYK+QL TR+VLVA+ETW ++ I+ NP+ L EF KYR+ IK+ +DAVHL S
Sbjct: 275 LIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQ 334
Query: 394 FHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSS-RKPKCDC 452
F RS +Y GG+CS +G GVNE+G +A L+QSLA N+GI + +C C
Sbjct: 335 FESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKC 394
Query: 453 TESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKLFEPTECGNGYVEA 512
++W GCIM +TG +KF++C+I EY DFL GGGACLFN+P+KL +P ECGNG++E
Sbjct: 395 EDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIET 454
Query: 513 GEECDCGFHVECY---GLCCKKCSLSNGAHCSDGPCCNNTSCLFQPRGYECRDAVNECDI 569
GEECDCG EC CCKKC+L+ + CSDG CC C FQP G CR+AVN+CDI
Sbjct: 455 GEECDCGTPAECVLEGAECCKKCTLTQDSQCSDGLCCKK--CKFQPMGTVCREAVNDCDI 512
Query: 570 TEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYIWGTKAAGSDKFCYEK 629
E C+G+S QC PN+HK DGY+C+ QG C+ G CKTRD QC+YIWG K SDK+CYEK
Sbjct: 513 RETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEK 572
Query: 630 LNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFYHQGRV 689
LN EGTEKGNCGKD D WIQC+K DV CG+LLCTN+ PR+G+L GEI T QGR
Sbjct: 573 LNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRT 632
Query: 690 IDCSGAHVVLDDDTDVGYVEDGTPCGPSMMCLDRKCLQIQALNMSSCPLDSKGKVCSGHG 749
++CSG HV L++D D+GYVEDGTPCGP MMCL+ +CL + + N S+C +G +CSG+G
Sbjct: 633 LNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNG 692
Query: 750 VCSNEATCICDFTWAGTDCSIRDPVRNLHPPKDEGPK--------GPSATNLIIGSIAGA 801
VCSNE C+C+ W G+DC N + P ++ K G + TN+IIG IAG
Sbjct: 693 VCSNELKCVCNRHWIGSDC-------NTYFPHNDDAKTGITLSGNGVAGTNIIIGIIAGT 745
Query: 802 ILVAAIVLGGTGWGFKNVKKRR 823
ILV A++LG T WG+KN +++R
Sbjct: 746 ILVLALILGITAWGYKNYREQR 767
>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
[Homo sapiens]
Length = 823
Score = 754 bits (1948), Expect = 0.0
Identities = 372/742 (50%), Positives = 489/742 (65%), Gaps = 44/742 (5%)
Query: 107 MQKEITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDL 166
++++ +P RLIY + ES + LDT+ R + H+ QASFQ++AFG+ FILD+
Sbjct: 45 VERQSIVPLRLIYRSGGEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDV 104
Query: 167 ILNNGLLSSDYVEIHYENG-KPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDD 225
+LN+ LLSS+Y+E H E+G K KGGEHCYY G IRG DS VALSTC+GLHGMF D
Sbjct: 105 VLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDG 164
Query: 226 TFVYMIEPLELVHDEKSTGRP----HIIQKTLAGQYSK-------QMKNLTMERGDQWPF 274
Y+IEP +E T + H + K+ ++S Q N+T + F
Sbjct: 165 NHTYLIEP-----EENDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSK-----F 214
Query: 275 LSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVD 334
+ + + + +++ R + EE KY+ELMIVNDH +KKHR S HTN +AKSVVN+ D
Sbjct: 215 ILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMAD 274
Query: 335 SIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQR-IKQHADAVHLISRVT 393
IYK+QL TR+VLVA+ETW ++ I+ NP+ L EF KYR+ IK+ +DAVHL S
Sbjct: 275 LIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQ 334
Query: 394 FHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSS-RKPKCDC 452
F RS +Y GG+CS +G GVNE+G +A L+QSLA N+GI + +C C
Sbjct: 335 FESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKC 394
Query: 453 TESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKLFEPTECGNGYVEA 512
++W GCIM +TG +KF++C+I EY DFL GGGACLFN+P+KL +P ECGNG++E
Sbjct: 395 EDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIET 454
Query: 513 GEECDCGFHVECY---GLCCKKCSLSNGAHCSDGPCCNNTSCLFQPRGYECRDAVNECDI 569
GEECDCG EC CCKKC+L+ + CSDG CC C FQP G CR+AVN+CDI
Sbjct: 455 GEECDCGTPAECVLEGAECCKKCTLTQDSQCSDGLCCKK--CKFQPMGTVCREAVNDCDI 512
Query: 570 TEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYIWGTKAAGSDKFCYEK 629
E C+G+S QC PN+HK DGY+C+ QG C+ G CKTRD QC+YIWG K SDK+CYEK
Sbjct: 513 RETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEK 572
Query: 630 LNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFYHQGRV 689
LN EGTEKGNCGKD D WIQC+K DV CG+LLCTN+ PR+G+L GEI T QGR
Sbjct: 573 LNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRT 632
Query: 690 IDCSGAHVVLDDDTDVGYVEDGTPCGPSMMCLDRKCLQIQALNMSSCPLDSKGKVCSGHG 749
++CSG HV L++D D+GYVEDGTPCGP MMCL+ +CL + + N S+C +G +CSG+G
Sbjct: 633 LNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNG 692
Query: 750 VCSNEATCICDFTWAGTDCSIRDPVRNLHPPKDEGPK--------GPSATNLIIGSIAGA 801
VCSNE C+C+ W G+DC N + P ++ K G + TN+IIG IAG
Sbjct: 693 VCSNELKCVCNRHWIGSDC-------NTYFPHNDDAKTGITLSGNGVAGTNIIIGIIAGT 745
Query: 802 ILVAAIVLGGTGWGFKNVKKRR 823
ILV A++LG T WG+KN +++R
Sbjct: 746 ILVLALILGITAWGYKNYREQR 767
>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
[Homo sapiens]
Length = 870
Score = 754 bits (1948), Expect = 0.0
Identities = 372/742 (50%), Positives = 489/742 (65%), Gaps = 44/742 (5%)
Query: 107 MQKEITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDL 166
++++ +P RLIY + ES + LDT+ R + H+ QASFQ++AFG+ FILD+
Sbjct: 45 VERQSIVPLRLIYRSGGEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDV 104
Query: 167 ILNNGLLSSDYVEIHYENG-KPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDD 225
+LN+ LLSS+Y+E H E+G K KGGEHCYY G IRG DS VALSTC+GLHGMF D
Sbjct: 105 VLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDG 164
Query: 226 TFVYMIEPLELVHDEKSTGRP----HIIQKTLAGQYSK-------QMKNLTMERGDQWPF 274
Y+IEP +E T + H + K+ ++S Q N+T + F
Sbjct: 165 NHTYLIEP-----EENDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSK-----F 214
Query: 275 LSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVD 334
+ + + + +++ R + EE KY+ELMIVNDH +KKHR S HTN +AKSVVN+ D
Sbjct: 215 ILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMAD 274
Query: 335 SIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQR-IKQHADAVHLISRVT 393
IYK+QL TR+VLVA+ETW ++ I+ NP+ L EF KYR+ IK+ +DAVHL S
Sbjct: 275 LIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQ 334
Query: 394 FHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSS-RKPKCDC 452
F RS +Y GG+CS +G GVNE+G +A L+QSLA N+GI + +C C
Sbjct: 335 FESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKC 394
Query: 453 TESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKLFEPTECGNGYVEA 512
++W GCIM +TG +KF++C+I EY DFL GGGACLFN+P+KL +P ECGNG++E
Sbjct: 395 EDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIET 454
Query: 513 GEECDCGFHVECY---GLCCKKCSLSNGAHCSDGPCCNNTSCLFQPRGYECRDAVNECDI 569
GEECDCG EC CCKKC+L+ + CSDG CC C FQP G CR+AVN+CDI
Sbjct: 455 GEECDCGTPAECVLEGAECCKKCTLTQDSQCSDGLCCKK--CKFQPMGTVCREAVNDCDI 512
Query: 570 TEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYIWGTKAAGSDKFCYEK 629
E C+G+S QC PN+HK DGY+C+ QG C+ G CKTRD QC+YIWG K SDK+CYEK
Sbjct: 513 RETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEK 572
Query: 630 LNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFYHQGRV 689
LN EGTEKGNCGKD D WIQC+K DV CG+LLCTN+ PR+G+L GEI T QGR
Sbjct: 573 LNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRT 632
Query: 690 IDCSGAHVVLDDDTDVGYVEDGTPCGPSMMCLDRKCLQIQALNMSSCPLDSKGKVCSGHG 749
++CSG HV L++D D+GYVEDGTPCGP MMCL+ +CL + + N S+C +G +CSG+G
Sbjct: 633 LNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNG 692
Query: 750 VCSNEATCICDFTWAGTDCSIRDPVRNLHPPKDEGPK--------GPSATNLIIGSIAGA 801
VCSNE C+C+ W G+DC N + P ++ K G + TN+IIG IAG
Sbjct: 693 VCSNELKCVCNRHWIGSDC-------NTYFPHNDDAKTGITLSGNGVAGTNIIIGIIAGT 745
Query: 802 ILVAAIVLGGTGWGFKNVKKRR 823
ILV A++LG T WG+KN +++R
Sbjct: 746 ILVLALILGITAWGYKNYREQR 767
>gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprotein
[Homo sapiens]
Length = 859
Score = 754 bits (1948), Expect = 0.0
Identities = 372/742 (50%), Positives = 489/742 (65%), Gaps = 44/742 (5%)
Query: 107 MQKEITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDL 166
++++ +P RLIY + ES + LDT+ R + H+ QASFQ++AFG+ FILD+
Sbjct: 45 VERQSIVPLRLIYRSGGEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDV 104
Query: 167 ILNNGLLSSDYVEIHYENG-KPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDD 225
+LN+ LLSS+Y+E H E+G K KGGEHCYY G IRG DS VALSTC+GLHGMF D
Sbjct: 105 VLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDG 164
Query: 226 TFVYMIEPLELVHDEKSTGRP----HIIQKTLAGQYSK-------QMKNLTMERGDQWPF 274
Y+IEP +E T + H + K+ ++S Q N+T + F
Sbjct: 165 NHTYLIEP-----EENDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSK-----F 214
Query: 275 LSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVD 334
+ + + + +++ R + EE KY+ELMIVNDH +KKHR S HTN +AKSVVN+ D
Sbjct: 215 ILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMAD 274
Query: 335 SIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQR-IKQHADAVHLISRVT 393
IYK+QL TR+VLVA+ETW ++ I+ NP+ L EF KYR+ IK+ +DAVHL S
Sbjct: 275 LIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQ 334
Query: 394 FHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSS-RKPKCDC 452
F RS +Y GG+CS +G GVNE+G +A L+QSLA N+GI + +C C
Sbjct: 335 FESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKC 394
Query: 453 TESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKLFEPTECGNGYVEA 512
++W GCIM +TG +KF++C+I EY DFL GGGACLFN+P+KL +P ECGNG++E
Sbjct: 395 EDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIET 454
Query: 513 GEECDCGFHVECY---GLCCKKCSLSNGAHCSDGPCCNNTSCLFQPRGYECRDAVNECDI 569
GEECDCG EC CCKKC+L+ + CSDG CC C FQP G CR+AVN+CDI
Sbjct: 455 GEECDCGTPAECVLEGAECCKKCTLTQDSQCSDGLCCKK--CKFQPMGTVCREAVNDCDI 512
Query: 570 TEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYIWGTKAAGSDKFCYEK 629
E C+G+S QC PN+HK DGY+C+ QG C+ G CKTRD QC+YIWG K SDK+CYEK
Sbjct: 513 RETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEK 572
Query: 630 LNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFYHQGRV 689
LN EGTEKGNCGKD D WIQC+K DV CG+LLCTN+ PR+G+L GEI T QGR
Sbjct: 573 LNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRT 632
Query: 690 IDCSGAHVVLDDDTDVGYVEDGTPCGPSMMCLDRKCLQIQALNMSSCPLDSKGKVCSGHG 749
++CSG HV L++D D+GYVEDGTPCGP MMCL+ +CL + + N S+C +G +CSG+G
Sbjct: 633 LNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNG 692
Query: 750 VCSNEATCICDFTWAGTDCSIRDPVRNLHPPKDEGPK--------GPSATNLIIGSIAGA 801
VCSNE C+C+ W G+DC N + P ++ K G + TN+IIG IAG
Sbjct: 693 VCSNELKCVCNRHWIGSDC-------NTYFPHNDDAKTGITLSGNGVAGTNIIIGIIAGT 745
Query: 802 ILVAAIVLGGTGWGFKNVKKRR 823
ILV A++LG T WG+KN +++R
Sbjct: 746 ILVLALILGITAWGYKNYREQR 767
>gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo
sapiens]
Length = 769
Score = 753 bits (1943), Expect = 0.0
Identities = 383/727 (52%), Positives = 477/727 (65%), Gaps = 20/727 (2%)
Query: 110 EITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILN 169
E+T PSRL+ + E LDT+ R + VHLAQ SF I AF S F LDL LN
Sbjct: 46 EVTEPSRLVRE-SSGGEVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELN 104
Query: 170 NGLLSSDYVEIHYEN-GKPQYSKG-GEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTF 227
+ LLSS YVE H+ G Q+S G G+HCYY G +RG S ALSTC GLHG+F D
Sbjct: 105 HHLLSSQYVERHFSREGTTQHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNL 164
Query: 228 VYMIEPLELVHD--EKSTGRPHIIQKT--LAGQYS-KQMKNLTMERGDQWPFLSELQWLK 282
Y++EP E+ PH+I +T L ++ L P K
Sbjct: 165 TYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGCREPGCLFAVPAQSAPPNRPRLRRK 224
Query: 283 RRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLN 342
R+ R +P+ + E KY+EL+++NDH+ +++ R S T+NFAKSVVNL D IYKEQLN
Sbjct: 225 RQVRRGHPT--VHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLN 282
Query: 343 TRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQR-IKQHADAVHLISRVTFHYKRSSL 401
TR+VLVA+ETW + D+I + + ++ L YR+ + + +DA HL S TF S
Sbjct: 283 TRIVLVAMETWADGDKIQVQDDLLETLARLMVYRREGLPEPSDATHLFSGRTFQSTSSGA 342
Query: 402 SYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPS-SRKPKCDCTESWGGCI 460
+Y GG+CS + G GVNEYG A+A L+Q+L QNLG+ W S C C + W GCI
Sbjct: 343 AYVGGICSLSHGGGVNEYGNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCI 402
Query: 461 MEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKLFEPTECGNGYVEAGEECDCGF 520
ME+TG RKFS+CSI EY FLQ GGG+CLFN+P KL +P ECGNG+VEAGEECDCG
Sbjct: 403 MEDTGFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGS 462
Query: 521 HVECY---GLCCKKCSLSNGAHCSDGPCCNNTSCLFQPRGYECRDAVNECDITEYCTGDS 577
EC G CCKKC+L++ A CSDG CC C ++PRG CR+AVNECDI E CTGDS
Sbjct: 463 VQECSRAGGNCCKKCTLTHDAMCSDGLCCRR--CKYEPRGVSCREAVNECDIAETCTGDS 520
Query: 578 GQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEK 637
QCPPNLHK DGY C+ QGRCY G CKTRD QCQ +WG AA D+FCYEKLN EGTE+
Sbjct: 521 SQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQVLWGHAAA--DRFCYEKLNVEGTER 578
Query: 638 GNCGKDGDRWIQCSKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHV 697
G+CG+ G W+QCSK DV CGFLLC N++ APR+G L G+I +FYHQG+ +DC G HV
Sbjct: 579 GSCGRKGSGWVQCSKQDVLCGFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHV 638
Query: 698 VLDDDTDVGYVEDGTPCGPSMMCLDRKCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATC 757
L D +D+ YVEDGT CGP+M+CLD +CL A N S+CP + ++CS HGVCSNE C
Sbjct: 639 QLADGSDLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKC 698
Query: 758 ICDFTWAGTDCSIRDPVRNLHPP-KDEGPKGPSATNLIIGSIAGAILVAAIVLGGTGWGF 816
IC W G DCSI +P+ P + E KGPS TN+IIGSIAGA+LVAAIVLGGTGWGF
Sbjct: 699 ICQPDWTGKDCSIHNPLPTSPPTGETERYKGPSGTNIIIGSIAGAVLVAAIVLGGTGWGF 758
Query: 817 KNVKKRR 823
KN+++ R
Sbjct: 759 KNIRRGR 765
>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
sapiens]
Length = 918
Score = 361 bits (927), Expect = 1e-99
Identities = 224/684 (32%), Positives = 327/684 (47%), Gaps = 47/684 (6%)
Query: 147 HLAQASFQIEAFGSKFILDLILNNGLLSSDYVEIHY-ENGKPQYS--KGGEHCYYHGSIR 203
H +A ++ A G + ILDL N L + Y E HY +G PQ + K +HC+YHG++R
Sbjct: 61 HPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVR 120
Query: 204 GVKDSKVALSTCNGLHGMFE-DDTFVYMIEPLELVHDEKSTGRPHIIQKTLAGQYSKQMK 262
+ S V LSTC G+ G+ Y+IEPL + R ++ + K
Sbjct: 121 ETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQHLIYRSEHLKPPPGNCGFEHSK 180
Query: 263 NLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHT 322
T + W Q KR +R R MKY+EL +V D+ ++K+R T
Sbjct: 181 PTTRD----WALQFTQQTKKRPRRM---KREDLNSMKYVELYLVADYLEFQKNRRDQDAT 233
Query: 323 NNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQRI--K 380
+ + N VD Y+ LN R+ LV +E WT + +++ NP L F +R+++ +
Sbjct: 234 KHKLIEIANYVDKFYRS-LNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQ 292
Query: 381 QHADAVHLISRVTFHYKRSSLSYFGGVCS--RTRGVGVNEYGLPMAVAQVLSQSLAQNLG 438
++ D LI+ ++FH L+ +CS ++ GV ++ + VA ++ + N G
Sbjct: 293 KYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFG 352
Query: 439 IQWEPSSRKPKCDCTESWGGCIMEE-TGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPT 497
+ + + C + + GGCIM TG + F+ C+ E +LQ GGG CL N P
Sbjct: 353 MTHDSADC---CSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPD 409
Query: 498 K--LFEPTECGNGYVEAGEECDCGFHVECYGLCCK--KCSLSNGAHCSDGPCCNNTSCLF 553
L+ CGNGY+E GEECDCG EC CC C+L GA C+ G CC+ C
Sbjct: 410 TRMLYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQ--CKL 467
Query: 554 QPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQY 613
G CR+ +CD+ E+CTG S CP N ++ DG C Q CYNG C T QCQ
Sbjct: 468 LAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQ 527
Query: 614 IWGTKAAGSDKFCYEKLNTEGTEKGNCGKD-GDRWIQCSKHDVFCGFLLCTNLTRAPRIG 672
+WG A + C+EK+N G GNCGKD +C+ D CG + C + P
Sbjct: 528 LWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARP--- 584
Query: 673 QLQGEIIP--TSFYHQGRVIDCSGAHVVL-----DDDTDVGYVEDGTPCGPSMMCLDRKC 725
L+ +P T+ GR I C G HV D D G V GT CG + +C + +C
Sbjct: 585 -LESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQC 643
Query: 726 LQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIRDPVRNLHPPKDEGP 785
C GK C+GHGVC+N C C WA C+ ++ D GP
Sbjct: 644 RNTSFFETEGC-----GKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSI----DSGP 694
Query: 786 KGPSATNLIIGSIAGAILVAAIVL 809
P + ++ + AILV A+++
Sbjct: 695 MPPESVGPVVAGVLVAILVLAVLM 718
>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
[Homo sapiens]
Length = 738
Score = 354 bits (909), Expect = 2e-97
Identities = 212/645 (32%), Positives = 307/645 (47%), Gaps = 44/645 (6%)
Query: 147 HLAQASFQIEAFGSKFILDLILNNGLLSSDYVEIHYENGKPQYSKGGE------HCYYHG 200
H + +++ + I++L N GL++S + E HY S HCYYHG
Sbjct: 64 HPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHG 123
Query: 201 SIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQ----KTLAGQ 256
+RG DS V+LSTC+GL G+ + Y++EP++ +T R + K++ G
Sbjct: 124 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMK-----SATNRYKLFPAKKLKSVRGS 178
Query: 257 YSKQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHR 316
+ + +P S+ W +R KR + KY+EL+IV D++ +++
Sbjct: 179 CGSHHNTPNLAAKNVFPPPSQT-WARRHKRET------LKATKYVELVIVADNREFQRQG 231
Query: 317 SSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYR 376
+ N VD Y+ LN R+VLV VE W + D+ ++ +P LHEF +R
Sbjct: 232 KDLEKVKQRLIEIANHVDKFYRP-LNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWR 290
Query: 377 QRI----KQHADAVHLISRVTFHYKRSSLSYFGGVCS--RTRGVGVNEYGLPMAVAQVLS 430
+ K H D L+S V F ++ +C+ ++ G+ ++ P+ A L+
Sbjct: 291 KMKLLPRKSH-DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLA 349
Query: 431 QSLAQNLGIQWEPSSRKPKCDCTESWGGCIME-ETGVSHSRKFSKCSILEYRDFLQRGGG 489
L N G+ + R C GGCIM TG FS CS + L++G G
Sbjct: 350 HELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMG 409
Query: 490 ACLFNRPT--KLFEPTECGNGYVEAGEECDCGFHVECYGLCCKK--CSLSNGAHCSDGPC 545
CLFN P + F +CGN +VE GEECDCG EC CC C+L A C+ G C
Sbjct: 410 VCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLC 469
Query: 546 CNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECK 605
C + C +P G CRD+ N CD+ E+CTG S CP N++ DG++C G CYNG C+
Sbjct: 470 CED--CQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQ 527
Query: 606 TRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGK-DGDRWIQCSKHDVFCGFLLCTN 664
T + QC +WG A + C+E++N+ G GNCGK + +C D CG + C
Sbjct: 528 THEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQG 587
Query: 665 LTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDD-TDVGYVEDGTPCGPSMMCLDR 723
P IG I QG I C G HV L DD D G V GT C +CL+R
Sbjct: 588 GASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNR 647
Query: 724 KCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDC 768
+C I + C + C G GVC+N C C+ WA C
Sbjct: 648 QCQNISVFGVHECAMQ-----CHGRGVCNNRKNCHCEAHWAPPFC 687
>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
[Homo sapiens]
Length = 909
Score = 354 bits (909), Expect = 2e-97
Identities = 212/645 (32%), Positives = 307/645 (47%), Gaps = 44/645 (6%)
Query: 147 HLAQASFQIEAFGSKFILDLILNNGLLSSDYVEIHYENGKPQYSKGGE------HCYYHG 200
H + +++ + I++L N GL++S + E HY S HCYYHG
Sbjct: 64 HPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHG 123
Query: 201 SIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQ----KTLAGQ 256
+RG DS V+LSTC+GL G+ + Y++EP++ +T R + K++ G
Sbjct: 124 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMK-----SATNRYKLFPAKKLKSVRGS 178
Query: 257 YSKQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHR 316
+ + +P S+ W +R KR + KY+EL+IV D++ +++
Sbjct: 179 CGSHHNTPNLAAKNVFPPPSQT-WARRHKRET------LKATKYVELVIVADNREFQRQG 231
Query: 317 SSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYR 376
+ N VD Y+ LN R+VLV VE W + D+ ++ +P LHEF +R
Sbjct: 232 KDLEKVKQRLIEIANHVDKFYRP-LNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWR 290
Query: 377 QRI----KQHADAVHLISRVTFHYKRSSLSYFGGVCS--RTRGVGVNEYGLPMAVAQVLS 430
+ K H D L+S V F ++ +C+ ++ G+ ++ P+ A L+
Sbjct: 291 KMKLLPRKSH-DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLA 349
Query: 431 QSLAQNLGIQWEPSSRKPKCDCTESWGGCIME-ETGVSHSRKFSKCSILEYRDFLQRGGG 489
L N G+ + R C GGCIM TG FS CS + L++G G
Sbjct: 350 HELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMG 409
Query: 490 ACLFNRPT--KLFEPTECGNGYVEAGEECDCGFHVECYGLCCKK--CSLSNGAHCSDGPC 545
CLFN P + F +CGN +VE GEECDCG EC CC C+L A C+ G C
Sbjct: 410 VCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLC 469
Query: 546 CNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECK 605
C + C +P G CRD+ N CD+ E+CTG S CP N++ DG++C G CYNG C+
Sbjct: 470 CED--CQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQ 527
Query: 606 TRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGK-DGDRWIQCSKHDVFCGFLLCTN 664
T + QC +WG A + C+E++N+ G GNCGK + +C D CG + C
Sbjct: 528 THEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQG 587
Query: 665 LTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDD-TDVGYVEDGTPCGPSMMCLDR 723
P IG I QG I C G HV L DD D G V GT C +CL+R
Sbjct: 588 GASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNR 647
Query: 724 KCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDC 768
+C I + C + C G GVC+N C C+ WA C
Sbjct: 648 QCQNISVFGVHECAMQ-----CHGRGVCNNRKNCHCEAHWAPPFC 687
>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
sapiens]
Length = 819
Score = 334 bits (856), Expect = 2e-91
Identities = 212/644 (32%), Positives = 314/644 (48%), Gaps = 54/644 (8%)
Query: 150 QASFQIEAFGSKFILDLILNNGLLSSDYVEIHYENGKP---QYSKGGEHCYYHGSIRGVK 206
Q S+ I+A G + I+ L N LL D+V Y + HC+Y G + GV
Sbjct: 65 QVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVH 124
Query: 207 DSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKT--------LAGQYS 258
+S +ALS C GL G+ + Y IEPL+ S+ HII + G +
Sbjct: 125 NSSIALSDCFGLRGLLHLENASYGIEPLQ-----NSSHFEHIIYRMDDVYKEPLKCGVSN 179
Query: 259 KQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSS 318
K ++ T + ++ P + L RR+RAV P + +Y+EL IV D + Y +
Sbjct: 180 KDIEKETAKDEEEEP--PSMTQLLRRRRAVLP------QTRYVELFIVVDKERYDMMGRN 231
Query: 319 HAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQR 378
+ N +DS+Y LN R+VLV +E WT + I+I +L F ++R++
Sbjct: 232 QTAVREEMILLANYLDSMYI-MLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREK 290
Query: 379 I---KQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYG--LPMAVAQVLSQSL 433
++ D+ L+ + F + +++ G VCSR+ G+N +G A +++ L
Sbjct: 291 FLITRRRHDSAQLVLKKGFG-GTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHEL 349
Query: 434 AQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLF 493
NLG+ + DC+ CIM +G S SR FS CS ++ GG CL
Sbjct: 350 GHNLGMNHDDGR-----DCSCGAKSCIMN-SGASGSRNFSSCSAEDFEKLTLNKGGNCLL 403
Query: 494 N--RPTKLFEPTECGNGYVEAGEECDCGFHVEC-YGLCCK--KCSLSNGAHCSDGPCCNN 548
N +P + + CGN V+AGEECDCG EC CC+ C L + A C+ G CC +
Sbjct: 404 NIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKD 463
Query: 549 TSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRD 608
C F P G CR +ECD+ EYC G S C P++ Q+GY C N+ CYNG C+ D
Sbjct: 464 --CRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYD 521
Query: 609 NQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTNLTRA 668
QCQ I+G+KA + K C+ ++N++G GNCG G+ + +C+ + CG L C N+
Sbjct: 522 AQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEI 581
Query: 669 PRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDT-DVGYVEDGTPCGPSMMCLDRKCLQ 727
P G I+P R C G L D D G V +GT CG +C + +C+
Sbjct: 582 PVFG-----IVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVD 636
Query: 728 IQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIR 771
LN C + K C GHGVC++ C C+ WA +C +
Sbjct: 637 ASVLNY-DCDVQKK---CHGHGVCNSNKNCHCENGWAPPNCETK 676
>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
preproprotein [Homo sapiens]
Length = 813
Score = 318 bits (814), Expect = 2e-86
Identities = 206/639 (32%), Positives = 315/639 (49%), Gaps = 53/639 (8%)
Query: 155 IEAFGSKFILDLILNNGLLSSDYVEIHY-ENGKPQYSKGG--EHCYYHGSIRGVKDSKVA 211
+EA G + +L+L N+ LL+ Y+E HY +G+P +HC+Y G +RG DS V
Sbjct: 70 LEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVV 129
Query: 212 LSTCNGLHGMFE-DDTFVYMIEPLELVHDEK-STGRPHIIQKTLAGQYSKQMKNLTMERG 269
L TC+G+ G+ Y + P + ST +++ L + + ++ + G
Sbjct: 130 LCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAG 189
Query: 270 DQWPFLSELQW--LKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAK 327
++ L R +R +R KYLEL IV DH + + HT
Sbjct: 190 -----MTSLPGGPQSRGRREARRTR------KYLELYIVADHTLFLTRHRNLNHTKQRLL 238
Query: 328 SVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQRI--KQHADA 385
V N VD + + L+ +V L +E WTE+D+ +T + L F ++R+ + ++ D+
Sbjct: 239 EVANYVDQLLRT-LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDS 297
Query: 386 VHLISRVTFHYKRSSLSYFGGVC--SRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEP 443
L++ F L+ G+C + GV + LP+ A ++ + +LG+ +P
Sbjct: 298 AQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDP 357
Query: 444 SSRKPKCDCTESW---GGCIMEE-TGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKL 499
C C E+ GGC+M TG R FS CS + R F ++GGGACL N P
Sbjct: 358 DG----C-CVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPG 412
Query: 500 FE--PTECGNGYVEAGEECDCGFHVECYGLCC--KKCSLSNGAHCSDGPCCNNTSCLFQP 555
P CGNG+VEAGEECDCG EC LCC CSL GA C+ G CC CL +P
Sbjct: 413 LPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCC--VRCLLKP 470
Query: 556 RGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYIW 615
G CR A+ +CD+ E+CTG S CPP+++ DG C + G C++G C T + QCQ +W
Sbjct: 471 AGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLW 530
Query: 616 GTKAAGSDKFCYEKLNTEGTEKGNCGKDGD-RWIQCSKHDVFCGFLLCTNLTRAPRIGQL 674
G + + + C++ +N+ G GNCG+D + ++ C+ D CG L C + + L
Sbjct: 531 GPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQC----QGGKPSLL 586
Query: 675 QGEIIP--TSFYHQGRVIDCSGAHVVLDDDTD---VGYVEDGTPCGPSMMCLDRKCLQIQ 729
++P ++ + G+ + C GA + D +G VE GT CGP M+C R+C +
Sbjct: 587 APHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNA 646
Query: 730 ALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDC 768
+ C C HGVC++ C C WA C
Sbjct: 647 FQELQRCL-----TACHSHGVCNSNHNCHCAPGWAPPFC 680
>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
preproprotein [Homo sapiens]
Length = 787
Score = 296 bits (759), Expect = 4e-80
Identities = 193/591 (32%), Positives = 297/591 (50%), Gaps = 48/591 (8%)
Query: 155 IEAFGSKFILDLILNNGLLSSDYVEIHY-ENGKPQYSKGG--EHCYYHGSIRGVKDSKVA 211
+EA G + +L+L N+ LL+ Y+E HY +G+P +HC+Y G +RG DS V
Sbjct: 70 LEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVV 129
Query: 212 LSTCNGLHGMFE-DDTFVYMIEPLELVHDEK-STGRPHIIQKTLAGQYSKQMKNLTMERG 269
L TC+G+ G+ Y + P + ST +++ L + + ++ + G
Sbjct: 130 LCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAG 189
Query: 270 DQWPFLSELQW--LKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAK 327
++ L R +R +R KYLEL IV DH + + HT
Sbjct: 190 -----MTSLPGGPQSRGRREARRTR------KYLELYIVADHTLFLTRHRNLNHTKQRLL 238
Query: 328 SVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQRI--KQHADA 385
V N VD + + L+ +V L +E WTE+D+ +T + L F ++R+ + ++ D+
Sbjct: 239 EVANYVDQLLRT-LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDS 297
Query: 386 VHLISRVTFHYKRSSLSYFGGVC--SRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEP 443
L++ F L+ G+C + GV + LP+ A ++ + +LG+ +P
Sbjct: 298 AQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDP 357
Query: 444 SSRKPKCDCTESW---GGCIMEE-TGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKL 499
C C E+ GGC+M TG R FS CS + R F ++GGGACL N P
Sbjct: 358 DG----C-CVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPG 412
Query: 500 FE--PTECGNGYVEAGEECDCGFHVECYGLCC--KKCSLSNGAHCSDGPCCNNTSCLFQP 555
P CGNG+VEAGEECDCG EC LCC CSL GA C+ G CC CL +P
Sbjct: 413 LPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCC--VRCLLKP 470
Query: 556 RGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYIW 615
G CR A+ +CD+ E+CTG S CPP+++ DG C + G C++G C T + QCQ +W
Sbjct: 471 AGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLW 530
Query: 616 GTKAAGSDKFCYEKLNTEGTEKGNCGKDGD-RWIQCSKHDVFCGFLLCTNLTRAPRIGQL 674
G + + + C++ +N+ G GNCG+D + ++ C+ D CG L C + + L
Sbjct: 531 GPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQC----QGGKPSLL 586
Query: 675 QGEIIP--TSFYHQGRVIDCSGAHVVLDDDTD---VGYVEDGTPCGPSMMC 720
++P ++ + G+ + C GA + D +G VE GT CGP M+C
Sbjct: 587 APHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVC 637
>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
preproprotein [Homo sapiens]
Length = 863
Score = 295 bits (755), Expect = 1e-79
Identities = 195/640 (30%), Positives = 300/640 (46%), Gaps = 50/640 (7%)
Query: 154 QIEAFGSKFILDLILNNGLLSSDYVEIHYE-NGKPQYSKGG--EHCYYHGSIRGVKDSKV 210
++E G IL+L+ N L+ + Y+ +G S+G E+C Y G +RG S V
Sbjct: 72 KLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWV 131
Query: 211 ALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGR---PHIIQKT----LAGQYS--KQM 261
++ TC+GL G+ ++ P E+ G P II + L G
Sbjct: 132 SICTCSGLRGLV-------VLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWR 184
Query: 262 KNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAH 321
+++ ++ + P +R + R + E K +EL+IV DH +K+R H
Sbjct: 185 ESVHTQKPPEHPL---------GQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-H 234
Query: 322 TNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQRI-- 379
N V L+D+ ++ LN RV LV +E WT++D ++I+ NP L F +R+
Sbjct: 235 LLNRTLEVALLLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLL 293
Query: 380 -KQHADAVHLISRVTFHYKRSSLSYFGGVCSR--TRGVGVNEYGLPMAVAQVLSQSLAQN 436
+ D+ L++ +F ++ +CS + GV ++ + VA ++ L +
Sbjct: 294 PRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHS 353
Query: 437 LGIQWEPSSRKPKCDCTESWGGCIME-ETGVSHSRKFSKCSILEYRDFLQRGGGACLFNR 495
LG+ + C CIME T FS CS L G G+CLF R
Sbjct: 354 LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER 413
Query: 496 -PTKLFEPTECGNGYVEAGEECDCGFHVECYGLCCKK--CSLSNGAHC-SDGPCCNNTSC 551
P+ CGN +VE GE+CDCGF +C CC C L GA C SDGPCC N C
Sbjct: 414 LPSLPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQN--C 471
Query: 552 LFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQC 611
+P G++CR +CD+ E+C GDS QCPP++ DG C Q C +G C + QC
Sbjct: 472 QLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQC 531
Query: 612 QYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKD-GDRWIQCSKHDVFCGFLLCTNLTRAPR 670
Q +WG A + C + NT G G+CG++ ++ C+ D CG L C P
Sbjct: 532 QSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPL 591
Query: 671 IGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVE-DGTPCGPSMMCLDRKCLQIQ 729
+G ++ +++ + G ++CS H+ L D + GT CGP ++C+D +C ++
Sbjct: 592 LGSIR-DLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650
Query: 730 ALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCS 769
L C C GHGVC + C C+ WA DC+
Sbjct: 651 LLGAQEC-----RSKCHGHGVCDSNRHCYCEEGWAPPDCT 685
>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
preproprotein [Homo sapiens]
Length = 862
Score = 295 bits (755), Expect = 1e-79
Identities = 195/640 (30%), Positives = 300/640 (46%), Gaps = 50/640 (7%)
Query: 154 QIEAFGSKFILDLILNNGLLSSDYVEIHYE-NGKPQYSKGG--EHCYYHGSIRGVKDSKV 210
++E G IL+L+ N L+ + Y+ +G S+G E+C Y G +RG S V
Sbjct: 72 KLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWV 131
Query: 211 ALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGR---PHIIQKT----LAGQYS--KQM 261
++ TC+GL G+ ++ P E+ G P II + L G
Sbjct: 132 SICTCSGLRGLV-------VLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWR 184
Query: 262 KNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAH 321
+++ ++ + P +R + R + E K +EL+IV DH +K+R H
Sbjct: 185 ESVHTQKPPEHPL---------GQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-H 234
Query: 322 TNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQRI-- 379
N V L+D+ ++ LN RV LV +E WT++D ++I+ NP L F +R+
Sbjct: 235 LLNRTLEVALLLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLL 293
Query: 380 -KQHADAVHLISRVTFHYKRSSLSYFGGVCSR--TRGVGVNEYGLPMAVAQVLSQSLAQN 436
+ D+ L++ +F ++ +CS + GV ++ + VA ++ L +
Sbjct: 294 PRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHS 353
Query: 437 LGIQWEPSSRKPKCDCTESWGGCIME-ETGVSHSRKFSKCSILEYRDFLQRGGGACLFNR 495
LG+ + C CIME T FS CS L G G+CLF R
Sbjct: 354 LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER 413
Query: 496 -PTKLFEPTECGNGYVEAGEECDCGFHVECYGLCCKK--CSLSNGAHC-SDGPCCNNTSC 551
P+ CGN +VE GE+CDCGF +C CC C L GA C SDGPCC N C
Sbjct: 414 LPSLPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQN--C 471
Query: 552 LFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQC 611
+P G++CR +CD+ E+C GDS QCPP++ DG C Q C +G C + QC
Sbjct: 472 QLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQC 531
Query: 612 QYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKD-GDRWIQCSKHDVFCGFLLCTNLTRAPR 670
Q +WG A + C + NT G G+CG++ ++ C+ D CG L C P
Sbjct: 532 QSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPL 591
Query: 671 IGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVE-DGTPCGPSMMCLDRKCLQIQ 729
+G ++ +++ + G ++CS H+ L D + GT CGP ++C+D +C ++
Sbjct: 592 LGSIR-DLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650
Query: 730 ALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCS 769
L C C GHGVC + C C+ WA DC+
Sbjct: 651 LLGAQEC-----RSKCHGHGVCDSNRHCYCEEGWAPPDCT 685
>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
preproprotein [Homo sapiens]
Length = 838
Score = 295 bits (755), Expect = 1e-79
Identities = 195/640 (30%), Positives = 300/640 (46%), Gaps = 50/640 (7%)
Query: 154 QIEAFGSKFILDLILNNGLLSSDYVEIHYE-NGKPQYSKGG--EHCYYHGSIRGVKDSKV 210
++E G IL+L+ N L+ + Y+ +G S+G E+C Y G +RG S V
Sbjct: 72 KLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWV 131
Query: 211 ALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGR---PHIIQKT----LAGQYS--KQM 261
++ TC+GL G+ ++ P E+ G P II + L G
Sbjct: 132 SICTCSGLRGLV-------VLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWR 184
Query: 262 KNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAH 321
+++ ++ + P +R + R + E K +EL+IV DH +K+R H
Sbjct: 185 ESVHTQKPPEHPL---------GQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-H 234
Query: 322 TNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQRI-- 379
N V L+D+ ++ LN RV LV +E WT++D ++I+ NP L F +R+
Sbjct: 235 LLNRTLEVALLLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLL 293
Query: 380 -KQHADAVHLISRVTFHYKRSSLSYFGGVCSR--TRGVGVNEYGLPMAVAQVLSQSLAQN 436
+ D+ L++ +F ++ +CS + GV ++ + VA ++ L +
Sbjct: 294 PRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHS 353
Query: 437 LGIQWEPSSRKPKCDCTESWGGCIME-ETGVSHSRKFSKCSILEYRDFLQRGGGACLFNR 495
LG+ + C CIME T FS CS L G G+CLF R
Sbjct: 354 LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER 413
Query: 496 -PTKLFEPTECGNGYVEAGEECDCGFHVECYGLCCKK--CSLSNGAHC-SDGPCCNNTSC 551
P+ CGN +VE GE+CDCGF +C CC C L GA C SDGPCC N C
Sbjct: 414 LPSLPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQN--C 471
Query: 552 LFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQC 611
+P G++CR +CD+ E+C GDS QCPP++ DG C Q C +G C + QC
Sbjct: 472 QLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQC 531
Query: 612 QYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKD-GDRWIQCSKHDVFCGFLLCTNLTRAPR 670
Q +WG A + C + NT G G+CG++ ++ C+ D CG L C P
Sbjct: 532 QSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPL 591
Query: 671 IGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVE-DGTPCGPSMMCLDRKCLQIQ 729
+G ++ +++ + G ++CS H+ L D + GT CGP ++C+D +C ++
Sbjct: 592 LGSIR-DLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650
Query: 730 ALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCS 769
L C C GHGVC + C C+ WA DC+
Sbjct: 651 LLGAQEC-----RSKCHGHGVCDSNRHCYCEEGWAPPDCT 685
>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
preproprotein [Homo sapiens]
Length = 839
Score = 295 bits (755), Expect = 1e-79
Identities = 195/640 (30%), Positives = 300/640 (46%), Gaps = 50/640 (7%)
Query: 154 QIEAFGSKFILDLILNNGLLSSDYVEIHYE-NGKPQYSKGG--EHCYYHGSIRGVKDSKV 210
++E G IL+L+ N L+ + Y+ +G S+G E+C Y G +RG S V
Sbjct: 72 KLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWV 131
Query: 211 ALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGR---PHIIQKT----LAGQYS--KQM 261
++ TC+GL G+ ++ P E+ G P II + L G
Sbjct: 132 SICTCSGLRGLV-------VLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWR 184
Query: 262 KNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAH 321
+++ ++ + P +R + R + E K +EL+IV DH +K+R H
Sbjct: 185 ESVHTQKPPEHPL---------GQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-H 234
Query: 322 TNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQRI-- 379
N V L+D+ ++ LN RV LV +E WT++D ++I+ NP L F +R+
Sbjct: 235 LLNRTLEVALLLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLL 293
Query: 380 -KQHADAVHLISRVTFHYKRSSLSYFGGVCSR--TRGVGVNEYGLPMAVAQVLSQSLAQN 436
+ D+ L++ +F ++ +CS + GV ++ + VA ++ L +
Sbjct: 294 PRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHS 353
Query: 437 LGIQWEPSSRKPKCDCTESWGGCIME-ETGVSHSRKFSKCSILEYRDFLQRGGGACLFNR 495
LG+ + C CIME T FS CS L G G+CLF R
Sbjct: 354 LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER 413
Query: 496 -PTKLFEPTECGNGYVEAGEECDCGFHVECYGLCCKK--CSLSNGAHC-SDGPCCNNTSC 551
P+ CGN +VE GE+CDCGF +C CC C L GA C SDGPCC N C
Sbjct: 414 LPSLPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQN--C 471
Query: 552 LFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQC 611
+P G++CR +CD+ E+C GDS QCPP++ DG C Q C +G C + QC
Sbjct: 472 QLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQC 531
Query: 612 QYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKD-GDRWIQCSKHDVFCGFLLCTNLTRAPR 670
Q +WG A + C + NT G G+CG++ ++ C+ D CG L C P
Sbjct: 532 QSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPL 591
Query: 671 IGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVE-DGTPCGPSMMCLDRKCLQIQ 729
+G ++ +++ + G ++CS H+ L D + GT CGP ++C+D +C ++
Sbjct: 592 LGSIR-DLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650
Query: 730 ALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCS 769
L C C GHGVC + C C+ WA DC+
Sbjct: 651 LLGAQEC-----RSKCHGHGVCDSNRHCYCEEGWAPPDCT 685
>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
preproprotein [Homo sapiens]
Length = 772
Score = 295 bits (755), Expect = 1e-79
Identities = 195/640 (30%), Positives = 300/640 (46%), Gaps = 50/640 (7%)
Query: 154 QIEAFGSKFILDLILNNGLLSSDYVEIHYE-NGKPQYSKGG--EHCYYHGSIRGVKDSKV 210
++E G IL+L+ N L+ + Y+ +G S+G E+C Y G +RG S V
Sbjct: 72 KLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWV 131
Query: 211 ALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGR---PHIIQKT----LAGQYS--KQM 261
++ TC+GL G+ ++ P E+ G P II + L G
Sbjct: 132 SICTCSGLRGLV-------VLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWR 184
Query: 262 KNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAH 321
+++ ++ + P +R + R + E K +EL+IV DH +K+R H
Sbjct: 185 ESVHTQKPPEHPL---------GQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-H 234
Query: 322 TNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQRI-- 379
N V L+D+ ++ LN RV LV +E WT++D ++I+ NP L F +R+
Sbjct: 235 LLNRTLEVALLLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLL 293
Query: 380 -KQHADAVHLISRVTFHYKRSSLSYFGGVCSR--TRGVGVNEYGLPMAVAQVLSQSLAQN 436
+ D+ L++ +F ++ +CS + GV ++ + VA ++ L +
Sbjct: 294 PRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHS 353
Query: 437 LGIQWEPSSRKPKCDCTESWGGCIME-ETGVSHSRKFSKCSILEYRDFLQRGGGACLFNR 495
LG+ + C CIME T FS CS L G G+CLF R
Sbjct: 354 LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER 413
Query: 496 -PTKLFEPTECGNGYVEAGEECDCGFHVECYGLCCKK--CSLSNGAHC-SDGPCCNNTSC 551
P+ CGN +VE GE+CDCGF +C CC C L GA C SDGPCC N C
Sbjct: 414 LPSLPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQN--C 471
Query: 552 LFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQC 611
+P G++CR +CD+ E+C GDS QCPP++ DG C Q C +G C + QC
Sbjct: 472 QLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQC 531
Query: 612 QYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKD-GDRWIQCSKHDVFCGFLLCTNLTRAPR 670
Q +WG A + C + NT G G+CG++ ++ C+ D CG L C P
Sbjct: 532 QSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPL 591
Query: 671 IGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVE-DGTPCGPSMMCLDRKCLQIQ 729
+G ++ +++ + G ++CS H+ L D + GT CGP ++C+D +C ++
Sbjct: 592 LGSIR-DLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650
Query: 730 ALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCS 769
L C C GHGVC + C C+ WA DC+
Sbjct: 651 LLGAQEC-----RSKCHGHGVCDSNRHCYCEEGWAPPDCT 685
>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
preproprotein [Homo sapiens]
Length = 814
Score = 295 bits (755), Expect = 1e-79
Identities = 195/640 (30%), Positives = 300/640 (46%), Gaps = 50/640 (7%)
Query: 154 QIEAFGSKFILDLILNNGLLSSDYVEIHYE-NGKPQYSKGG--EHCYYHGSIRGVKDSKV 210
++E G IL+L+ N L+ + Y+ +G S+G E+C Y G +RG S V
Sbjct: 72 KLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWV 131
Query: 211 ALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGR---PHIIQKT----LAGQYS--KQM 261
++ TC+GL G+ ++ P E+ G P II + L G
Sbjct: 132 SICTCSGLRGLV-------VLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWR 184
Query: 262 KNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAH 321
+++ ++ + P +R + R + E K +EL+IV DH +K+R H
Sbjct: 185 ESVHTQKPPEHPL---------GQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-H 234
Query: 322 TNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQRI-- 379
N V L+D+ ++ LN RV LV +E WT++D ++I+ NP L F +R+
Sbjct: 235 LLNRTLEVALLLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLL 293
Query: 380 -KQHADAVHLISRVTFHYKRSSLSYFGGVCSR--TRGVGVNEYGLPMAVAQVLSQSLAQN 436
+ D+ L++ +F ++ +CS + GV ++ + VA ++ L +
Sbjct: 294 PRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHS 353
Query: 437 LGIQWEPSSRKPKCDCTESWGGCIME-ETGVSHSRKFSKCSILEYRDFLQRGGGACLFNR 495
LG+ + C CIME T FS CS L G G+CLF R
Sbjct: 354 LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER 413
Query: 496 -PTKLFEPTECGNGYVEAGEECDCGFHVECYGLCCKK--CSLSNGAHC-SDGPCCNNTSC 551
P+ CGN +VE GE+CDCGF +C CC C L GA C SDGPCC N C
Sbjct: 414 LPSLPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQN--C 471
Query: 552 LFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQC 611
+P G++CR +CD+ E+C GDS QCPP++ DG C Q C +G C + QC
Sbjct: 472 QLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQC 531
Query: 612 QYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKD-GDRWIQCSKHDVFCGFLLCTNLTRAPR 670
Q +WG A + C + NT G G+CG++ ++ C+ D CG L C P
Sbjct: 532 QSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPL 591
Query: 671 IGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVE-DGTPCGPSMMCLDRKCLQIQ 729
+G ++ +++ + G ++CS H+ L D + GT CGP ++C+D +C ++
Sbjct: 592 LGSIR-DLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650
Query: 730 ALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCS 769
L C C GHGVC + C C+ WA DC+
Sbjct: 651 LLGAQEC-----RSKCHGHGVCDSNRHCYCEEGWAPPDCT 685
>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
sapiens]
Length = 754
Score = 293 bits (751), Expect = 3e-79
Identities = 200/649 (30%), Positives = 312/649 (48%), Gaps = 64/649 (9%)
Query: 153 FQIEAFGSKFILDLILNNGLLSSDYVEIHYENGKPQYSKGGE---HCYYHGSIRGVKDSK 209
++I+ +L L+ + L S+Y E Y +++ + HC+Y GSI DS
Sbjct: 61 YEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSA 120
Query: 210 VALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTLAGQYSKQMKNLTMERG 269
++STCNGL G F + Y+IEP++ + + H++ K NL + G
Sbjct: 121 ASISTCNGLRGFFRINDQRYLIEPVKYSDEGE-----HLVFKY----------NLRVPYG 165
Query: 270 DQWPFLSELQWLKRRKRAVNPS------RGIFEEMKYLELMIVNDHKTYKKHRSSHAHTN 323
+ +EL + ++ N S +GI +E KY+EL IV D Y+++ H
Sbjct: 166 ANYS-CTELNFTRKTVPGDNESEEDSKIKGIHDE-KYVELFIVADDTVYRRNGHPHNKLR 223
Query: 324 NFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQRI---K 380
N +VN V+ IYK LN V LV +E WT +D+I++ +N L FS ++++I +
Sbjct: 224 NRIWGMVNFVNMIYKT-LNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTR 282
Query: 381 QHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMA--VAQVLSQSLAQNLG 438
+ D V L+S + +SY GG+C + + LP +A ++ L NLG
Sbjct: 283 KDFDHVVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLG 342
Query: 439 IQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPT- 497
+Q + + CT G C+M+ G + KFSKCS +Y +L+ C+ N P
Sbjct: 343 MQHD------EFPCTCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFP 396
Query: 498 -KLFEPTECGNGYVEAGEECDCGFHVECYGLCCKK--CSLSNGAHCSDGPCCNNTSCLFQ 554
+ CGN ++ GEECDCG EC CC C L G C++G CC SC +
Sbjct: 397 YNFHDFQFCGNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCE--SCQIK 454
Query: 555 PRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYI 614
G CR A +ECD E CTG S CP + + +G+ C ++G C+ G+C TR++QC +
Sbjct: 455 KAGSICRPAKDECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSEL 514
Query: 615 WGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTNLTRAPRIGQL 674
+ +A S CY K+NT+G + G C +R++ C + DV CG + CT G+L
Sbjct: 515 FDDEAIESHDICY-KMNTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTG-------GEL 566
Query: 675 QGEIIPTSFYH-----QGRVIDCSGAHVVLDDDTDVGYVEDGTPCGPSMMCLDRKCLQIQ 729
+ YH + + C + D TD+G V GT CG M+C + +CL ++
Sbjct: 567 SSLLGEDKTYHLKDPQKNATVKCK-TIFLYHDSTDIGLVASGTKCGEGMVCNNGECLNME 625
Query: 730 ALNMS-SCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIRDPVRNL 777
+ +S +CP GHG+ C C+ A C V N+
Sbjct: 626 KVYISTNCPSQCNENPVDGHGL-----QCHCEEGQAPVACEETLHVTNI 669
>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
[Homo sapiens]
Length = 775
Score = 293 bits (749), Expect = 6e-79
Identities = 203/661 (30%), Positives = 302/661 (45%), Gaps = 62/661 (9%)
Query: 128 PYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILNNGLLSSDYVEIHYENGKP 187
P H + K QQ+ + + +++ G +L L N LL+ Y E +Y +
Sbjct: 38 PLHKREAKEPEQQEQFET----ELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGK 93
Query: 188 QYSKGGE---HCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTG 244
+ + + CYY G I K S ++STC GL G F Y IEPL +H + G
Sbjct: 94 EITTSPQIMDDCYYQGHILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRD---G 150
Query: 245 RPHIIQKTLAGQYSKQMKNLTMERG-DQWPFLSELQW---LKRRKRAVNPSRGIFEEMKY 300
+ H + K Y+ KN G D + +LQ L K R + E KY
Sbjct: 151 QEHALFK-----YNPDEKNYDSTCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKY 205
Query: 301 LELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQID 360
+E +V D+ +K++ + + N V+ +YK+ LNT V LV +E WT+KD+I
Sbjct: 206 IEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNMLYKK-LNTHVALVGMEIWTDKDKIK 264
Query: 361 ITTNPVQMLHEFSKYR----QRIKQHADAVHLISRVTFHYKRSSLSYFGGVCSR-TRGVG 415
IT N L FSK+R R K+H D LI+ L++ +CS + GV
Sbjct: 265 ITPNASFTLENFSKWRGSVLSRRKRH-DIAQLITATELAGTTVGLAFMSTMCSPYSVGVV 323
Query: 416 VNEYGLPMAVAQVLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSH-SRKFSK 474
+ + VA ++ + N G+ + S C C + C+M++ + FS
Sbjct: 324 QDHSDNLLRVAGTMAHEMGHNFGMFHDDYS----CKCPSTI--CVMDKALSFYIPTDFSS 377
Query: 475 CSILEYRDFLQRGGGACLFNRP--TKLFEPTECGNGYVEAGEECDCGFHVECYGLCC--K 530
CS L Y F + CLFN P T + CGN VE GE+CDCG EC +CC K
Sbjct: 378 CSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAK 437
Query: 531 KCSLSNGAHCSDGPCCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGY 590
C + C+ G CC C F+ G CR A +ECD+ E C G SG CP + + +G+
Sbjct: 438 TCKIKATFQCALGECCEK--CQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGF 495
Query: 591 ACNQNQGRCYNGECKTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQC 650
C+ +G C G C T QC +WG +DK CY + N G++ G C + D I C
Sbjct: 496 PCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSCYNR-NEGGSKYGYCRRVDDTLIPC 554
Query: 651 SKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDT--DVGYV 708
+D CG L C Q + +P +GR++ +DT ++G V
Sbjct: 555 KANDTMCGKLFC----------QGGSDNLP----WKGRIVTFLTCKTFDPEDTSQEIGMV 600
Query: 709 EDGTPCGPSMMCLDRKCLQIQ-ALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTD 767
+GT CG + +C++ +C+ I+ A ++C C GH VC +E C C+ W D
Sbjct: 601 ANGTKCGDNKVCINAECVDIEKAYKSTNC-----SSKCKGHAVCDHELQCQCEEGWIPPD 655
Query: 768 C 768
C
Sbjct: 656 C 656
>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
sapiens]
Length = 722
Score = 274 bits (700), Expect = 3e-73
Identities = 182/593 (30%), Positives = 290/593 (48%), Gaps = 49/593 (8%)
Query: 194 EHCYYHGSIRGVKDSKVALSTC-NGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKT 252
+ CYYHG + G +S V S C G G+ + Y IEP+ S H++ K
Sbjct: 107 DDCYYHGYVEGAPESLVVFSACFGGFRGVLKISGLTYEIEPIR-----HSATFEHLVYKV 161
Query: 253 LAGQYSKQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSRG--IFEEMKYLELMIVNDHK 310
+ + Q + ++ +L++ + A+ P + +LEL++V +H
Sbjct: 162 NSNE--TQFPAMRCGLTEKEVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHD 219
Query: 311 TYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLH 370
+ +S+ + VVN+VDS+Y +QL T ++L+ +E W + + +T+ Q+L+
Sbjct: 220 FFIYSQSNISKVQEDVFLVVNIVDSMY-QQLGTYIILIGIEIWNQGNVFPMTSIE-QVLN 277
Query: 371 EFSKYRQ---RIKQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEY--GLPMAV 425
+FS+++Q QH DA H+ + + L+Y G+C GV+ +
Sbjct: 278 DFSQWKQISLSQLQH-DAAHMFIKNSL-ISILGLAYVAGICRPPIDCGVDNFQGDTWSLF 335
Query: 426 AQVLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQ 485
A ++ L LG+Q + C C E GCIM V + KF+ CS Y DF++
Sbjct: 336 ANTVAHELGHTLGMQHDEEF----CFCGER--GCIMNTFRVP-AEKFTNCS---YADFMK 385
Query: 486 R--GGGACLFNRPT--KLFEPTECGNGYVEAGEECDCGFHVECY--GLCCKKCSLSNGAH 539
G+CL N P ++F CGNG VE E+CDCG +C C C+L GA
Sbjct: 386 TTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAA 445
Query: 540 CSDGPCCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRC 599
C+ G CC + C F P G CR VNECD+ E+C G S QCP + + QDG C+ + C
Sbjct: 446 CAFGLCCKD--CKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCSDS-AYC 502
Query: 600 YNGECKTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGF 659
Y C D C+ I+G A + + CY+++N++G G+CG +G +++C DVFCG
Sbjct: 503 YQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGTTYLKCHISDVFCGR 562
Query: 660 LLCTNLTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLD-DDTDVGYVEDGTPCGPSM 718
+ C N+ P LQ + G + C G L + +D+G V+DGT CGP
Sbjct: 563 VQCENVRDIP---LLQDHFTLQHTHING--VTCWGIDYHLRMNISDIGEVKDGTVCGPGK 617
Query: 719 MCLDRKCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIR 771
+C+ +KC+ + L+ P + C+ G+C+N+ C C + W+ C R
Sbjct: 618 ICIHKKCVSLSVLSHVCLP-----ETCNMKGICNNKHHCHCGYGWSPPYCQHR 665
>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
sapiens]
Length = 776
Score = 273 bits (699), Expect = 4e-73
Identities = 199/637 (31%), Positives = 298/637 (46%), Gaps = 55/637 (8%)
Query: 152 SFQIEAFGSKFILDLILNNGLLSSD-----YVEIHYENGKPQYSKGGEHCYYHGSIRGVK 206
S+ + G ++I+ + +N L ++ Y E H + + + CYYHG + GV
Sbjct: 112 SYSLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQ--DDCYYHGYVEGVP 169
Query: 207 DSKVALSTCNG-LHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTLAG--QYSKQMKN 263
+S VALSTC+G GM + + VY I+P+ + S H++ K + Q+
Sbjct: 170 ESLVALSTCSGGFLGMLQINDLVYEIKPISV-----SATFEHLVYKIDSDDTQFPPMRCG 224
Query: 264 LTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTN 323
LT E+ ELQ + G + +++EL++V D+ Y +S+
Sbjct: 225 LTEEK---IAHQMELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQ 281
Query: 324 NFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFS---KYRQRIK 380
+ +VVN+VDS Y L V+L ++ WT + + + + +L +FS Y +
Sbjct: 282 HEVFNVVNIVDSFY-HPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNR 340
Query: 381 QHADAVHLISRVTFHYKRSSLSYFGGVCSR--TRGVGVNEYGLPMAVAQVLSQSLAQNLG 438
D HL + T K ++Y G+C GV V E + A L L NLG
Sbjct: 341 LQHDVAHLFIKDTQGMKLG-VAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLG 399
Query: 439 IQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPT- 497
+Q + C C W CIM + KFS CS +Y D G C+ P
Sbjct: 400 MQHDTQW----CVCELQW--CIMHAYR-KVTTKFSNCSYAQYWDSTI-SSGLCIQPPPYP 451
Query: 498 -KLFEPTECGNGYVEAGEECDCGFHVECYG--LCCKKCSLSNGAHCSDGPCCNNTSCLFQ 554
+F CGN VE GEECDCG +C C C+L GA C+ G CC + C F
Sbjct: 452 GNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPCCLLNCTLHPGAACAFGICCKD--CKFL 509
Query: 555 PRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYI 614
P G CR V ECD+ E+C G S QCP +++ QDG +CN N CY C D QC+ I
Sbjct: 510 PSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISCNVN-AFCYEKTCNNHDIQCKEI 568
Query: 615 WGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTNLTRAPRIGQL 674
+G A + + CY+++NT+G G+CG G +++C D+ CG + C N+ P
Sbjct: 569 FGQDARSASQSCYQEINTQGNRFGHCGIVGTTYVKCWTPDIMCGRVQCENVGVIP----- 623
Query: 675 QGEIIPTSFYHQGRVID--CSGAHVVLD-DDTDVGYVEDGTPCGPSMMCLDRKCLQIQAL 731
+I S Q + D C G L D+G V+DGT CGP +C+ +KC + L
Sbjct: 624 --NLIEHSTVQQFHLNDTTCWGTDYHLGMAIPDIGEVKDGTVCGPEKICIRKKCASMVHL 681
Query: 732 NMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDC 768
+ + P K C+ G+C+N+ C C+ WA C
Sbjct: 682 SQACQP-----KTCNMRGICNNKQHCHCNHEWAPPYC 713
>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
Length = 856
Score = 270 bits (689), Expect = 5e-72
Identities = 194/659 (29%), Positives = 290/659 (44%), Gaps = 68/659 (10%)
Query: 128 PYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILNNGLLSSDYVEIHYE-NGK 186
P+ + + R + +H + S+ + A G F L L N LL S Y E + NG
Sbjct: 34 PWRLPGPRVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGS 93
Query: 187 P--QYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTG 244
+ +G +HC+Y G + G DS +LSTC GL G F+ + +++IEPL DE G
Sbjct: 94 EVTEQPRGQDHCFYQGHVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPL----DEGGEG 149
Query: 245 RPHIIQKT-----LAGQYSKQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMK 299
H + + AG +L G + + + R PSR E +
Sbjct: 150 GRHAVYQAEHLLQTAGTCGVSDDSLGSLLGPRTAAV-----FRPRPGDSLPSR----ETR 200
Query: 300 YLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQI 359
Y+EL +V D+ ++ S A + VVN VD +Y ++LN RVVLV +E W +D+
Sbjct: 201 YVELYVVVDNAEFQM-LGSEAAVRHRVLEVVNHVDKLY-QKLNFRVVLVGLEIWNSQDRF 258
Query: 360 DITTNPVQMLHEFSKY--RQRIKQHA-DAVHLISRVTFHYKRSSLSYFGGVCSRTRG-VG 415
++ +P L + RQR ++H D V LI+ V F + +CS + G V
Sbjct: 259 HVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVN 318
Query: 416 VNEYGLPMAVAQVLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIME-ETGVSHSRKFSK 474
+ P+ VA ++ + NLG+ + + + +C G CIM G S R FS
Sbjct: 319 QDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSD 378
Query: 475 CSILEYRDFLQRGGGACLFNRP--TKLFEPTECGNGYVEAGEECDCGFHVECYGLCCKK- 531
CS FL+R CL N P + L CGN +VE GE+CDCG +C CC
Sbjct: 379 CSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRNRCCNST 438
Query: 532 -CSLSNGAHCSDGPCCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGY 590
C L+ GA C+ G CC C +P G CR + CD+ E+C G +CP + +++G
Sbjct: 439 TCQLAEGAQCAHGTCCQ--ECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGT 496
Query: 591 ACNQNQGRCYNGECKTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQC 650
C + G CYNG C T QCQ WG +++ C+ G + D +QC
Sbjct: 497 PC--SGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVLQC 554
Query: 651 SKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVED 710
G +C ++D A + +D T V +
Sbjct: 555 KGGQQPLGRAIC--------------------------IVDVCHA-LTTEDGTAYEPVPE 587
Query: 711 GTPCGPSMMCLDRKCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCS 769
GT CGP +C +C + S+C C HGVC+++ C C WA C+
Sbjct: 588 GTRCGPEKVCWKGRCQDLHVYRSSNCSAQ-----CHNHGVCNHKQECHCHAGWAPPHCA 641
>gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo
sapiens]
Length = 735
Score = 265 bits (678), Expect = 1e-70
Identities = 185/649 (28%), Positives = 302/649 (46%), Gaps = 70/649 (10%)
Query: 149 AQASFQIEAFGSKFILDLILNNGLLSSDYVEIHYENG--KPQYSKGGEHCYYHGSIRGVK 206
+QAS++I G + ++L+ N L + V + G KP C+Y G I G
Sbjct: 43 SQASYKIVIEGKPYTVNLMQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYP 102
Query: 207 DSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTLAGQYSKQMKNLTM 266
S V +STC GL G+ + + Y IEPLE S G H+I + ++ K +L
Sbjct: 103 KSVVMVSTCTGLRGVLQFENVSYGIEPLE-----SSVGFEHVIYQV---KHKKADVSLYN 154
Query: 267 ERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFA 326
E+ E + L + ++V P + KY+E+ ++ + + Y S
Sbjct: 155 EKD------IESRDLSFKLQSVEPQQDF---AKYIEMHVIVEKQLYNHMGSDTTVVAQKV 205
Query: 327 KSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQR---IKQHA 383
++ L ++I+ N ++L ++E W ++++I T ++LH F +++ ++ H
Sbjct: 206 FQLIGLTNAIFVS-FNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLRPHD 264
Query: 384 DAVHLISR-------VTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQN 436
A L+ R TF K +Y GGV R + + ++A +L+Q L+ +
Sbjct: 265 VAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPRTISLE------SLAVILAQLLSLS 318
Query: 437 LGIQWEPSSRKPKCDCTESWGGCIMEETGVSHS--RKFSKCSILEYRDFLQRGGGACLFN 494
+GI ++ + KC C S CIM + S + FS CS ++ F+ + CL N
Sbjct: 319 MGITYDDIN---KCQC--SGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHN 373
Query: 495 RPTK---LFEPTECGNGYVEAGEECDCGFHVECYGL---CCK--KCSLSNGAHCSDGPCC 546
+P + CGN +EAGEECDCG +C + CC C G++C++GPCC
Sbjct: 374 QPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCC 433
Query: 547 NNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKT 606
N CLF + CR + ECD+ EYC G S CP N + Q G+ C NQ C +G C +
Sbjct: 434 EN--CLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMS 491
Query: 607 RDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTN-- 664
D QC +G + CY LN++ GNCG + QC ++ CG L+C
Sbjct: 492 GDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVG 551
Query: 665 --LTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVEDGTPCGPSMMCLD 722
L + PR + I H ++ + H D+ +++DGT CG + +C +
Sbjct: 552 KFLLQIPRATIIYANISG----HLCIAVEFASDHA----DSQKMWIKDGTSCGSNKVCRN 603
Query: 723 RKCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIR 771
++C+ L C D C+ GVC+N+ C C ++ DCS++
Sbjct: 604 QRCVSSSYLGY-DCTTDK----CNDRGVCNNKKHCHCSASYLPPDCSVQ 647
>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 260 bits (664), Expect = 4e-69
Identities = 180/606 (29%), Positives = 291/606 (48%), Gaps = 44/606 (7%)
Query: 195 HCYYHGSIRGVKDSKVALSTC-NGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTL 253
+CYYHG + G +S V+LSTC G G+ + + F Y I+PL ST H++ K
Sbjct: 99 NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAF-----STTFEHLVYK-- 151
Query: 254 AGQYSKQMKNLTMERG---DQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHK 310
S++ + TM G ++ E + + + + G + + +E+++V D+
Sbjct: 152 --MDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNY 209
Query: 311 TYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLH 370
Y ++ + + +VN+VDSI + + +V+L +E WT K+ I + + + +H
Sbjct: 210 LYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVH 267
Query: 371 EFSKYRQRI---KQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQ 427
+ K++ + D HL + + S + F G+C+ R + +
Sbjct: 268 LYCKWKSENITPRMQHDTSHLFTTLGLR-GLSGIGAFRGMCTPHRSCAIVTF--MNKTLG 324
Query: 428 VLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRG 487
S ++A +LG + + C C++ CIM E G KFS CS ++ ++
Sbjct: 325 TFSIAVAHHLGHNLGMNHDEDTCRCSQP--RCIMHE-GNPPITKFSNCSYGDFWEYTVER 381
Query: 488 GGACLFNRPTK-LFEPTECGNGYVEAGEECDCGFHVECYG--LCCKKCSLSNGAHCSDGP 544
L TK +F CGNG VE GEECDCG C C C+L++G+ C+ G
Sbjct: 382 TKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGL 441
Query: 545 CCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGEC 604
CC + C F P G CR VNECD+ E+C G S +CP + + +DG C + +G CY C
Sbjct: 442 CCKD--CKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCKE-RGYCYEKSC 498
Query: 605 KTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTN 664
R+ QC+ I+G A + + CY++LNT G G+CG +I+C+ DV CG + C N
Sbjct: 499 HDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCEN 558
Query: 665 LTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLD-DDTDVGYVEDGTPCGPSMMCLDR 723
+T P + T + + I C L D+G V+DGT CG +C+ R
Sbjct: 559 VTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHR 613
Query: 724 KCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIR---DPVRNLHPP 780
C+ I LN + P C+ G+C+N+ C C++ W +C I+ V + PP
Sbjct: 614 HCVHITILNSNCSP-----AFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPP 668
Query: 781 KDEGPK 786
K + K
Sbjct: 669 KRKKKK 674
>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 260 bits (664), Expect = 4e-69
Identities = 180/606 (29%), Positives = 291/606 (48%), Gaps = 44/606 (7%)
Query: 195 HCYYHGSIRGVKDSKVALSTC-NGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTL 253
+CYYHG + G +S V+LSTC G G+ + + F Y I+PL ST H++ K
Sbjct: 99 NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAF-----STTFEHLVYK-- 151
Query: 254 AGQYSKQMKNLTMERG---DQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHK 310
S++ + TM G ++ E + + + + G + + +E+++V D+
Sbjct: 152 --MDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNY 209
Query: 311 TYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLH 370
Y ++ + + +VN+VDSI + + +V+L +E WT K+ I + + + +H
Sbjct: 210 LYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVH 267
Query: 371 EFSKYRQRI---KQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQ 427
+ K++ + D HL + + S + F G+C+ R + +
Sbjct: 268 LYCKWKSENITPRMQHDTSHLFTTLGLR-GLSGIGAFRGMCTPHRSCAIVTF--MNKTLG 324
Query: 428 VLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRG 487
S ++A +LG + + C C++ CIM E G KFS CS ++ ++
Sbjct: 325 TFSIAVAHHLGHNLGMNHDEDTCRCSQP--RCIMHE-GNPPITKFSNCSYGDFWEYTVER 381
Query: 488 GGACLFNRPTK-LFEPTECGNGYVEAGEECDCGFHVECYG--LCCKKCSLSNGAHCSDGP 544
L TK +F CGNG VE GEECDCG C C C+L++G+ C+ G
Sbjct: 382 TKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGL 441
Query: 545 CCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGEC 604
CC + C F P G CR VNECD+ E+C G S +CP + + +DG C + +G CY C
Sbjct: 442 CCKD--CKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCKE-RGYCYEKSC 498
Query: 605 KTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTN 664
R+ QC+ I+G A + + CY++LNT G G+CG +I+C+ DV CG + C N
Sbjct: 499 HDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCEN 558
Query: 665 LTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLD-DDTDVGYVEDGTPCGPSMMCLDR 723
+T P + T + + I C L D+G V+DGT CG +C+ R
Sbjct: 559 VTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHR 613
Query: 724 KCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIR---DPVRNLHPP 780
C+ I LN + P C+ G+C+N+ C C++ W +C I+ V + PP
Sbjct: 614 HCVHITILNSNCSP-----AFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPP 668
Query: 781 KDEGPK 786
K + K
Sbjct: 669 KRKKKK 674
>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 260 bits (664), Expect = 4e-69
Identities = 180/606 (29%), Positives = 291/606 (48%), Gaps = 44/606 (7%)
Query: 195 HCYYHGSIRGVKDSKVALSTC-NGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTL 253
+CYYHG + G +S V+LSTC G G+ + + F Y I+PL ST H++ K
Sbjct: 99 NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAF-----STTFEHLVYK-- 151
Query: 254 AGQYSKQMKNLTMERG---DQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHK 310
S++ + TM G ++ E + + + + G + + +E+++V D+
Sbjct: 152 --MDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNY 209
Query: 311 TYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLH 370
Y ++ + + +VN+VDSI + + +V+L +E WT K+ I + + + +H
Sbjct: 210 LYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVH 267
Query: 371 EFSKYRQRI---KQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQ 427
+ K++ + D HL + + S + F G+C+ R + +
Sbjct: 268 LYCKWKSENITPRMQHDTSHLFTTLGLR-GLSGIGAFRGMCTPHRSCAIVTF--MNKTLG 324
Query: 428 VLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRG 487
S ++A +LG + + C C++ CIM E G KFS CS ++ ++
Sbjct: 325 TFSIAVAHHLGHNLGMNHDEDTCRCSQP--RCIMHE-GNPPITKFSNCSYGDFWEYTVER 381
Query: 488 GGACLFNRPTK-LFEPTECGNGYVEAGEECDCGFHVECYG--LCCKKCSLSNGAHCSDGP 544
L TK +F CGNG VE GEECDCG C C C+L++G+ C+ G
Sbjct: 382 TKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGL 441
Query: 545 CCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGEC 604
CC + C F P G CR VNECD+ E+C G S +CP + + +DG C + +G CY C
Sbjct: 442 CCKD--CKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCKE-RGYCYEKSC 498
Query: 605 KTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTN 664
R+ QC+ I+G A + + CY++LNT G G+CG +I+C+ DV CG + C N
Sbjct: 499 HDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCEN 558
Query: 665 LTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLD-DDTDVGYVEDGTPCGPSMMCLDR 723
+T P + T + + I C L D+G V+DGT CG +C+ R
Sbjct: 559 VTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHR 613
Query: 724 KCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIR---DPVRNLHPP 780
C+ I LN + P C+ G+C+N+ C C++ W +C I+ V + PP
Sbjct: 614 HCVHITILNSNCSP-----AFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPP 668
Query: 781 KDEGPK 786
K + K
Sbjct: 669 KRKKKK 674
>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 260 bits (664), Expect = 4e-69
Identities = 180/606 (29%), Positives = 291/606 (48%), Gaps = 44/606 (7%)
Query: 195 HCYYHGSIRGVKDSKVALSTC-NGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTL 253
+CYYHG + G +S V+LSTC G G+ + + F Y I+PL ST H++ K
Sbjct: 99 NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAF-----STTFEHLVYK-- 151
Query: 254 AGQYSKQMKNLTMERG---DQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHK 310
S++ + TM G ++ E + + + + G + + +E+++V D+
Sbjct: 152 --MDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNY 209
Query: 311 TYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLH 370
Y ++ + + +VN+VDSI + + +V+L +E WT K+ I + + + +H
Sbjct: 210 LYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVH 267
Query: 371 EFSKYRQRI---KQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQ 427
+ K++ + D HL + + S + F G+C+ R + +
Sbjct: 268 LYCKWKSENITPRMQHDTSHLFTTLGLR-GLSGIGAFRGMCTPHRSCAIVTF--MNKTLG 324
Query: 428 VLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRG 487
S ++A +LG + + C C++ CIM E G KFS CS ++ ++
Sbjct: 325 TFSIAVAHHLGHNLGMNHDEDTCRCSQP--RCIMHE-GNPPITKFSNCSYGDFWEYTVER 381
Query: 488 GGACLFNRPTK-LFEPTECGNGYVEAGEECDCGFHVECYG--LCCKKCSLSNGAHCSDGP 544
L TK +F CGNG VE GEECDCG C C C+L++G+ C+ G
Sbjct: 382 TKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGL 441
Query: 545 CCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGEC 604
CC + C F P G CR VNECD+ E+C G S +CP + + +DG C + +G CY C
Sbjct: 442 CCKD--CKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCKE-RGYCYEKSC 498
Query: 605 KTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTN 664
R+ QC+ I+G A + + CY++LNT G G+CG +I+C+ DV CG + C N
Sbjct: 499 HDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCEN 558
Query: 665 LTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLD-DDTDVGYVEDGTPCGPSMMCLDR 723
+T P + T + + I C L D+G V+DGT CG +C+ R
Sbjct: 559 VTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHR 613
Query: 724 KCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIR---DPVRNLHPP 780
C+ I LN + P C+ G+C+N+ C C++ W +C I+ V + PP
Sbjct: 614 HCVHITILNSNCSP-----AFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPP 668
Query: 781 KDEGPK 786
K + K
Sbjct: 669 KRKKKK 674
>gi|148664238 a disintegrin and metalloprotease domain 32 [Homo
sapiens]
Length = 787
Score = 258 bits (658), Expect = 2e-68
Identities = 209/731 (28%), Positives = 337/731 (46%), Gaps = 86/731 (11%)
Query: 110 EITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILN 169
+I +P ++ N SE Y + +K VHL Q F + F + + N
Sbjct: 27 QIVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLY-TVHLKQRYFLADNF-----MIYLYN 80
Query: 170 NGLLSSDYVEIHYENGKPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTFVY 229
G +++ +I + CYY G+I G DS V LSTC+GL G+ + + Y
Sbjct: 81 QGSMNTYSSDIQTQ------------CYYQGNIEGYPDSMVTLSTCSGLRGILQFENVSY 128
Query: 230 MIEPLELVHDEKSTGRPHIIQK------TLAGQYSKQMKNLTMERGDQWPFLSELQWLKR 283
IEPL E + H++ K +A + +K M D F+SE +
Sbjct: 129 GIEPL-----ESAVEFQHVLYKLKNEDNDIAIFIDRSLKEQPM---DDNIFISE-----K 175
Query: 284 RKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNT 343
+ AV + YLE+ IV D Y S N +V L +S++ Q
Sbjct: 176 SEPAVPDLFPL-----YLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMF-TQFKV 229
Query: 344 RVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQ---RIKQHADAVHLISRVTFHYKRSS 400
+VL ++E W+++++I ++L +F +++Q ++ H D +L+ + Y R
Sbjct: 230 TIVLSSLELWSDENKISTVGEADELLQKFLEWKQSYLNLRPH-DIAYLL--IYMDYPRYL 286
Query: 401 LSYFGGVCSRTR-GVGVNEYGLPM---AVAQVLSQSLAQNLGIQWEPSSRKPKCDCTESW 456
+ F G TR GV Y + A A +++Q LA +LGI ++ KC C+ES
Sbjct: 287 GAVFPGTMCITRYSAGVALYPKEITLEAFAVIVTQMLALSLGISYDDPK---KCQCSES- 342
Query: 457 GGCIMEETGVSHS--RKFSKCSILEYRDFLQRGGGACLFNRP--TKLFEPTECGNGYVEA 512
CIM V + + FS CS+ +++F+ G CL N+P K CGNG +E
Sbjct: 343 -TCIMNPEVVQSNGVKTFSSCSLRSFQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEG 401
Query: 513 GEECDCGFHVECYGLCC---KKCSLSNGAHCSDGPCCNNTSCLFQPRGYECRDAVN-ECD 568
E CDCG +C C + C L +GA C G CC + C G ECR + ECD
Sbjct: 402 NEICDCGTEAQCGPASCCDFRTCVLKDGAKCYKGLCCKD--CQILQSGVECRPKAHPECD 459
Query: 569 ITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYIWGTKAAGSDKFCYE 628
I E C G S +C P++ +G +C N+ CY+G+C D +C+ ++G + + CYE
Sbjct: 460 IAENCNGSSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYE 519
Query: 629 KLNTEGTEKGNCGKD-GDRWIQCSKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFYHQG 687
++ ++ GNCG+D ++++ C ++ CG L+CT TR P Q G++I Y
Sbjct: 520 EIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKP-FHQENGDVI----YAFV 574
Query: 688 RVIDCSGAHVVLDDDT-DVGYVEDGTPCGPSMMCLDRKCLQIQALNMSSCPLDSKGKVCS 746
R C L D V++G+ C +C++R+C++ + + S+ + CS
Sbjct: 575 RDSVCITVDYKLPRTVPDPLAVKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQ---CS 631
Query: 747 GHGVCSNEATCICDFTWAGTDCSIRDPVRNLHPPKDEG-----PKGPSATNLIIGSIAG- 800
GHGVC + C C + +C IR ++ P +D G G + ++G +
Sbjct: 632 GHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIAL 691
Query: 801 --AILVAAIVL 809
I+ AIVL
Sbjct: 692 PILIVTTAIVL 702
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.430
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,763,149
Number of Sequences: 37866
Number of extensions: 1900016
Number of successful extensions: 7515
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 186
Number of HSP's that attempted gapping in prelim test: 6242
Number of HSP's gapped (non-prelim): 947
length of query: 832
length of database: 18,247,518
effective HSP length: 111
effective length of query: 721
effective length of database: 14,044,392
effective search space: 10126006632
effective search space used: 10126006632
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.