Search of human proteins with 44662838

Search of human proteins with 44662838

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|44662838 aminomethyltransferase [Homo sapiens]
         (403 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|44662838 aminomethyltransferase [Homo sapiens]                     807   0.0  
gi|24797151 dimethylglycine dehydrogenase precursor [Homo sapiens]     91   2e-18
gi|197927446 sarcosine dehydrogenase precursor [Homo sapiens]          70   3e-12
gi|21361378 sarcosine dehydrogenase precursor [Homo sapiens]           70   3e-12
gi|194306651 pyruvate dehydrogenase phosphatase regulatory subun...    61   2e-09
gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sap...    29   6.6  
gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sap...    29   6.6  

>gi|44662838 aminomethyltransferase [Homo sapiens]
          Length = 403

 Score =  807 bits (2085), Expect = 0.0
 Identities = 403/403 (100%), Positives = 403/403 (100%)

Query: 1   MQRAVSVVARLGFRLQAFPPALCRPLSCAQEVLRRTPLYDFHLAHGGKMVAFAGWSLPVQ 60
           MQRAVSVVARLGFRLQAFPPALCRPLSCAQEVLRRTPLYDFHLAHGGKMVAFAGWSLPVQ
Sbjct: 1   MQRAVSVVARLGFRLQAFPPALCRPLSCAQEVLRRTPLYDFHLAHGGKMVAFAGWSLPVQ 60

Query: 61  YRDSHTDSHLHTRQHCSLFDVSHMLQTKILGSDRVKLMESLVVGDIAELRPNQGTLSLFT 120
           YRDSHTDSHLHTRQHCSLFDVSHMLQTKILGSDRVKLMESLVVGDIAELRPNQGTLSLFT
Sbjct: 61  YRDSHTDSHLHTRQHCSLFDVSHMLQTKILGSDRVKLMESLVVGDIAELRPNQGTLSLFT 120

Query: 121 NEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVLDNALL 180
           NEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVLDNALL
Sbjct: 121 NEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVLDNALL 180

Query: 181 ALQGPTAAQVLQAGVADDLRKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPVAGA 240
           ALQGPTAAQVLQAGVADDLRKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPVAGA
Sbjct: 181 ALQGPTAAQVLQAGVADDLRKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGVEISVPVAGA 240

Query: 241 VHLATAILKNPEVKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRAAM 300
           VHLATAILKNPEVKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRAAM
Sbjct: 241 VHLATAILKNPEVKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRAAM 300

Query: 301 DFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAHSPILNMEGTKIGTVTSGCPSPSLKKNV 360
           DFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAHSPILNMEGTKIGTVTSGCPSPSLKKNV
Sbjct: 301 DFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAHSPILNMEGTKIGTVTSGCPSPSLKKNV 360

Query: 361 AMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYYTLK 403
           AMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYYTLK
Sbjct: 361 AMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYYTLK 403


>gi|24797151 dimethylglycine dehydrogenase precursor [Homo sapiens]
          Length = 866

 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 101/376 (26%), Positives = 167/376 (44%), Gaps = 44/376 (11%)

Query: 53  AGWSLP---------VQYRDSHT---------DSHLHTRQHCSLFDVSHMLQTKILGSDR 94
           AGW  P          QYR S             +    Q  ++ D+S   +  I G D 
Sbjct: 488 AGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKFNIKGQDS 547

Query: 95  VKLMESLVVGDIAELRPNQG--TLSLFTNEAGGILDDLIVTNTSEGHLYVVSNAGCWEKD 152
           ++L++ L     A + P  G   +S      G +  +L V++ S G   +++ +G    D
Sbjct: 548 IRLLDHL----FANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSELHD 603

Query: 153 LALMQDKVRELQNQGRDVGLEVLDNAL--LALQGPTAAQVLQAGVADDLRK--LPFMTSA 208
           L  +++   E    G DV ++ + + L  L + GP A +VLQ   ++DL      F+ + 
Sbjct: 604 LRWIEE---EAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTK 660

Query: 209 VMEVFGVSGCRVTRCGYTGEDGVEISVPVAGAVHLATAILKNPE---VKLAGLAARDSLR 265
            ++V  +    + R  YTGE G E+      +V L  AI+   +   +   G  A ++LR
Sbjct: 661 SLKVSNIPVTAI-RISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALR 719

Query: 266 LEAGLCLYGNDIDEHTTPVEGSLSWTLGKRRRAAMDFPGAKVIVPQLKGRVQRRRVGLMC 325
           LE     +G +++  T P+E  L + +   + A  DF G K  + Q+K +  +RR  L+C
Sbjct: 720 LEKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPA--DFIG-KQALKQIKAKGLKRR--LVC 774

Query: 326 EGAPMRAHSPILN----MEGTKIGTVTSGCPSPSLKKNVAMGYVPCEYSRPGTMLLVEVR 381
                    P  N      G  +G  TSG  S S++K++A  YVP + S  G  + VE+ 
Sbjct: 775 LTLATDDVDPEGNESIWYNGKVVGNTTSGSYSYSIQKSLAFAYVPVQLSEVGQQVEVELL 834

Query: 382 RKQQMAVVSKMPFVPT 397
            K   AV+ + P V T
Sbjct: 835 GKNYPAVIIQEPLVLT 850


>gi|197927446 sarcosine dehydrogenase precursor [Homo sapiens]
          Length = 918

 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 85/371 (22%), Positives = 149/371 (40%), Gaps = 45/371 (12%)

Query: 61  YRDSHTDSHLHTRQHCSLFDVSHMLQTKILGSDRVKLMESLVVGDIAELRPNQGTLSLFT 120
           + D+     L  R   ++FD+S+  +  ++G D  K  + L   D++   P     +   
Sbjct: 553 HHDTIKKECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCML 611

Query: 121 NEAGGILDDLIVTNTS------------EGHLYVVSNAGC-----WEKDLALMQDKVREL 163
           N  GG   DL V+  +            EG  Y ++  G      W     ++QD+  + 
Sbjct: 612 NHRGGTESDLTVSRLAPSHQASPLAPAFEGDGYYLAMGGAVAQHNWSHITTVLQDQKSQC 671

Query: 164 Q--NQGRDVGLEVLDNALLALQGPTAAQVLQAGVADDLRK--LPFMTSAVMEVFGVSGCR 219
           Q  +   D+G+       +++QGP +  +LQ  +  DL     PF T  ++   G    R
Sbjct: 672 QLIDSSEDLGM-------ISIQGPASRAILQEVLDADLSNEAFPFSTHKLLRAAGHL-VR 723

Query: 220 VTRCGYTGEDGVEISVPVAGAVHLATAIL----KNPEVKLAGLAARDSLRLEAGLCLYGN 275
             R  + GE G E+ +P A  V +  A++    K+  +  AG  A DSL +E G   +  
Sbjct: 724 AMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKHGLIN-AGYRAIDSLSIEKGYRHWHA 782

Query: 276 DIDEHTTPVEGSLSWTLGKRRRAAMDFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAHSP 335
           D+    +P+E  L++T   + ++ + F G + +  Q    ++RR V    E         
Sbjct: 783 DLRPDDSPLEAGLAFTC--KLKSPVPFLGREALEQQRAAGLRRRLVCFTMEDKVPMFGLE 840

Query: 336 ILNMEGTKIGTVTSGCPSPSLKKNVAMGY--------VPCEYSRPGTMLLVEVRRKQQMA 387
            +   G  +G V       ++ K +A GY        V  ++ + G   L  +       
Sbjct: 841 AIWRNGQVVGHVRRADFGFAIDKTIAYGYIHDPSGGPVSLDFVKSGDYALERMGVTYGAQ 900

Query: 388 VVSKMPFVPTN 398
              K PF P N
Sbjct: 901 AHLKSPFDPNN 911


>gi|21361378 sarcosine dehydrogenase precursor [Homo sapiens]
          Length = 918

 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 85/371 (22%), Positives = 149/371 (40%), Gaps = 45/371 (12%)

Query: 61  YRDSHTDSHLHTRQHCSLFDVSHMLQTKILGSDRVKLMESLVVGDIAELRPNQGTLSLFT 120
           + D+     L  R   ++FD+S+  +  ++G D  K  + L   D++   P     +   
Sbjct: 553 HHDTIKKECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSR-PPGSTVYTCML 611

Query: 121 NEAGGILDDLIVTNTS------------EGHLYVVSNAGC-----WEKDLALMQDKVREL 163
           N  GG   DL V+  +            EG  Y ++  G      W     ++QD+  + 
Sbjct: 612 NHRGGTESDLTVSRLAPSHQASPLAPAFEGDGYYLAMGGAVAQHNWSHITTVLQDQKSQC 671

Query: 164 Q--NQGRDVGLEVLDNALLALQGPTAAQVLQAGVADDLRK--LPFMTSAVMEVFGVSGCR 219
           Q  +   D+G+       +++QGP +  +LQ  +  DL     PF T  ++   G    R
Sbjct: 672 QLIDSSEDLGM-------ISIQGPASRAILQEVLDADLSNEAFPFSTHKLLRAAGHL-VR 723

Query: 220 VTRCGYTGEDGVEISVPVAGAVHLATAIL----KNPEVKLAGLAARDSLRLEAGLCLYGN 275
             R  + GE G E+ +P A  V +  A++    K+  +  AG  A DSL +E G   +  
Sbjct: 724 AMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKHGLIN-AGYRAIDSLSIEKGYRHWHA 782

Query: 276 DIDEHTTPVEGSLSWTLGKRRRAAMDFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAHSP 335
           D+    +P+E  L++T   + ++ + F G + +  Q    ++RR V    E         
Sbjct: 783 DLRPDDSPLEAGLAFTC--KLKSPVPFLGREALEQQRAAGLRRRLVCFTMEDKVPMFGLE 840

Query: 336 ILNMEGTKIGTVTSGCPSPSLKKNVAMGY--------VPCEYSRPGTMLLVEVRRKQQMA 387
            +   G  +G V       ++ K +A GY        V  ++ + G   L  +       
Sbjct: 841 AIWRNGQVVGHVRRADFGFAIDKTIAYGYIHDPSGGPVSLDFVKSGDYALERMGVTYGAQ 900

Query: 388 VVSKMPFVPTN 398
              K PF P N
Sbjct: 901 AHLKSPFDPNN 911


>gi|194306651 pyruvate dehydrogenase phosphatase regulatory subunit
           [Homo sapiens]
          Length = 879

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 69/277 (24%), Positives = 111/277 (40%), Gaps = 58/277 (20%)

Query: 121 NEAGGILDDLIVTNTSEGHLYVVS----NAGCWE-------KDLALMQDKVRELQNQGRD 169
           NE GG  +D  +   ++   +++S       CW        KD  L+ + V         
Sbjct: 567 NEGGGYENDCSIARLNKRSFFMISPTDQQVHCWAWLKKHMPKDSNLLLEDV--------- 617

Query: 170 VGLEVLDNALLALQGPTAAQVLQ----AGVADDLRKLPFMTSAVMEVFGVSGCRVTRCGY 225
                     L L GP A  VL     A +  D    P +    M V   +G RV    +
Sbjct: 618 ----TWKYTALNLIGPRAVDVLSELSYAPMTPD--HFPSLFCKEMSVGYANGIRVMSMTH 671

Query: 226 TGEDGVEISVPVAGAVHLATAILKNPE---VKLAGLAARDSLRLEAGLCLYGNDIDEHTT 282
           TGE G  + +P+  A+H+   ++   +   ++ AG  A  SLR+E     +G DI+  TT
Sbjct: 672 TGEPGFMLYIPIEYALHVYNEVMSVGQKYGIRNAGYYALRSLRIEKFFAFWGQDINNLTT 731

Query: 283 PVEGSLSWTLGKRRRA----AMDFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAHSPILN 338
           P+E       G+  R      MDF G   ++ Q +  V +R    + +      H   L+
Sbjct: 732 PLE------CGRESRVKLEKGMDFIGRDALLQQKQNGVYKRLTMFILDD-----HDSDLD 780

Query: 339 M----------EGTKIGTVTSGCPSPSLKKNVAMGYV 365
           +           G  +G  TS   S SL+++V +G+V
Sbjct: 781 LWPWWGEPIYRNGQYVGKTTSSAYSYSLERHVCLGFV 817


>gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sapiens]
          Length = 2462

 Score = 29.3 bits (64), Expect = 6.6
 Identities = 14/46 (30%), Positives = 22/46 (47%)

Query: 316  VQRRRVGLMCEGAPMRAHSPILNMEGTKIGTVTSGCPSPSLKKNVA 361
            V  R++G + +G  ++ H P        +G VT G P P   K +A
Sbjct: 1108 VLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLA 1153


>gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sapiens]
          Length = 2524

 Score = 29.3 bits (64), Expect = 6.6
 Identities = 14/46 (30%), Positives = 22/46 (47%)

Query: 316  VQRRRVGLMCEGAPMRAHSPILNMEGTKIGTVTSGCPSPSLKKNVA 361
            V  R++G + +G  ++ H P        +G VT G P P   K +A
Sbjct: 1124 VLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLA 1169


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,017,941
Number of Sequences: 37866
Number of extensions: 657376
Number of successful extensions: 1555
Number of sequences better than 10.0: 7
Number of HSP's better than 10.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 1543
Number of HSP's gapped (non-prelim): 9
length of query: 403
length of database: 18,247,518
effective HSP length: 105
effective length of query: 298
effective length of database: 14,271,588
effective search space: 4252933224
effective search space used: 4252933224
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.