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Search of human proteins with 126723390
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
(1146 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|126723390 ankyrin repeat domain 24 [Homo sapiens] 2197 0.0
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 287 3e-77
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 286 8e-77
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 286 8e-77
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 286 8e-77
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 286 8e-77
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 265 2e-70
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 261 3e-69
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 257 5e-68
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 234 5e-61
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 126 1e-28
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 126 1e-28
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 126 1e-28
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 126 1e-28
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 126 1e-28
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 126 1e-28
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 126 1e-28
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 126 1e-28
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 118 3e-26
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 112 3e-24
gi|21735548 centrosomal protein 2 [Homo sapiens] 111 4e-24
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 109 1e-23
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 109 1e-23
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 109 1e-23
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 109 1e-23
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 109 2e-23
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 103 7e-22
gi|45439327 periplakin [Homo sapiens] 103 7e-22
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 103 9e-22
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 102 2e-21
>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
Length = 1146
Score = 2197 bits (5694), Expect = 0.0
Identities = 1146/1146 (100%), Positives = 1146/1146 (100%)
Query: 1 MKTLRARFKKTELRLSPTDLGSCPPCGPCPIPKPAARGRRQSQDWGKSDERLLQAVENND 60
MKTLRARFKKTELRLSPTDLGSCPPCGPCPIPKPAARGRRQSQDWGKSDERLLQAVENND
Sbjct: 1 MKTLRARFKKTELRLSPTDLGSCPPCGPCPIPKPAARGRRQSQDWGKSDERLLQAVENND 60
Query: 61 APRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMIAHGSNVMSADGAGYNALH 120
APRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMIAHGSNVMSADGAGYNALH
Sbjct: 61 APRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMIAHGSNVMSADGAGYNALH 120
Query: 121 LAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAGGCLSCSEVLCSFKAHLNPQDRS 180
LAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAGGCLSCSEVLCSFKAHLNPQDRS
Sbjct: 121 LAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAGGCLSCSEVLCSFKAHLNPQDRS 180
Query: 181 GATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALMLACEGASPETVEVLLQGGAQP 240
GATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALMLACEGASPETVEVLLQGGAQP
Sbjct: 181 GATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALMLACEGASPETVEVLLQGGAQP 240
Query: 241 GITDALGQDAAHYGALAGDKLILHLLQEAAQRPSPPSALTEDDSGEASSQNSMSSHGKQG 300
GITDALGQDAAHYGALAGDKLILHLLQEAAQRPSPPSALTEDDSGEASSQNSMSSHGKQG
Sbjct: 241 GITDALGQDAAHYGALAGDKLILHLLQEAAQRPSPPSALTEDDSGEASSQNSMSSHGKQG 300
Query: 301 APKKRKAPPPPASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSL 360
APKKRKAPPPPASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSL
Sbjct: 301 APKKRKAPPPPASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSL 360
Query: 361 HILERQVQELQQLLVERQEEKESLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELP 420
HILERQVQELQQLLVERQEEKESLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELP
Sbjct: 361 HILERQVQELQQLLVERQEEKESLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELP 420
Query: 421 DLPGAEVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEAL 480
DLPGAEVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEAL
Sbjct: 421 DLPGAEVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEAL 480
Query: 481 AEVIPLALYDSLRAEFDQLRRQHAEALQALRQQETREVPREEGAACGESEVAGATATKNG 540
AEVIPLALYDSLRAEFDQLRRQHAEALQALRQQETREVPREEGAACGESEVAGATATKNG
Sbjct: 481 AEVIPLALYDSLRAEFDQLRRQHAEALQALRQQETREVPREEGAACGESEVAGATATKNG 540
Query: 541 PTHMELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETK 600
PTHMELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETK
Sbjct: 541 PTHMELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETK 600
Query: 601 PTGAEVREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAG 660
PTGAEVREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAG
Sbjct: 601 PTGAEVREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAG 660
Query: 661 QAEPPVTGTTNMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEK 720
QAEPPVTGTTNMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEK
Sbjct: 661 QAEPPVTGTTNMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEK 720
Query: 721 LQVELETRIRGLEEALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGG 780
LQVELETRIRGLEEALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGG
Sbjct: 721 LQVELETRIRGLEEALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGG 780
Query: 781 GGDTTQLRAALEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQRE 840
GGDTTQLRAALEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQRE
Sbjct: 781 GGDTTQLRAALEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQRE 840
Query: 841 EARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLA 900
EARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLA
Sbjct: 841 EARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLA 900
Query: 901 ELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVC 960
ELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVC
Sbjct: 901 ELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVC 960
Query: 961 SVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQL 1020
SVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQL
Sbjct: 961 SVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQL 1020
Query: 1021 ATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALA 1080
ATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALA
Sbjct: 1021 ATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALA 1080
Query: 1081 TPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDVQRILSQILQMQR 1140
TPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDVQRILSQILQMQR
Sbjct: 1081 TPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDVQRILSQILQMQR 1140
Query: 1141 LQAQGR 1146
LQAQGR
Sbjct: 1141 LQAQGR 1146
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 287 bits (735), Expect = 3e-77
Identities = 274/1046 (26%), Positives = 465/1046 (44%), Gaps = 103/1046 (9%)
Query: 28 PCPIPKPAARGRRQSQDWGKSDERLLQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFH 87
P +P +A+ +++ +W K+D+RLLQAVEN DA +VA+L+ +KG TK D EGK+AFH
Sbjct: 3 PTYLPWLSAK-EKKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFH 61
Query: 88 LAAMRGAASCLEVMIAHGSNVMSADGAGYNALHLAAKYGHPQCLKQLLQASCVVDVVDSS 147
LAA +G CL VMI HG +V + D G++ALHLAAK H +C+++LLQ+ C + VDSS
Sbjct: 62 LAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSS 121
Query: 148 GWTALHHAAAGGCLSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLCRLLLQQGAAA 207
G TALH+AAA GCL ++LC K+ +N +D G PL++A Q H+++C LL GA
Sbjct: 122 GKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADV 181
Query: 208 NDQDLQGRTALMLACEGASPETVEVLLQGGAQPGITDALGQDAAHYGALAGD----KLIL 263
N ++ GRTALMLACE S VE L++ GA + D+LG +A HY L+ + L+L
Sbjct: 182 NSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLL 241
Query: 264 HLLQEAAQRPSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAY 323
+ + A +P D + SS+ S G PKKRKAPPPP S D +
Sbjct: 242 SKISQDADLKTPTKPKQHDQVSKISSERS-------GTPKKRKAPPPPISPTQLSDVSSP 294
Query: 324 EEIVRLRQERGRLL--------QKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLV 375
I + +I + ++K+R + A SL + + + Q LL
Sbjct: 295 RSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQ-QDLLS 353
Query: 376 ERQEEKESLGREVESLQSRL---SLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQ 432
Q + SL + LQ +L S E E + + + Q + G PG +
Sbjct: 354 LLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSK 413
Query: 433 LSPSAQEH-LASLQEQVAVLTRQNQELMEKVQ-ILENFEKDETQMEVEALAEVIPLALYD 490
SPS H L V +Q QE+++ +Q LE+ E + Q++VE + L +
Sbjct: 414 SSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLN 473
Query: 491 SLRAEFDQLRRQHAEALQALRQQETR-EVPREEGAACGESEVAGATATKNGPTHMELNGS 549
+ ++ ++ Q L++ +++ E +E + + G + ++ + +
Sbjct: 474 N-----TEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHEL 528
Query: 550 VAPETKVNG-AETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEVRE 608
E ++N + + E + + E E E K T KP E E
Sbjct: 529 RVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVER-------EKGTVIKPPVEEYEE 581
Query: 609 METT---------EEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGA 659
M+++ +E+A + K AQ + + + + T+ ++EAE
Sbjct: 582 MKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLK--DTLKSQMTQEASDEAE-------- 631
Query: 660 GQAEPPVTGTTNMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASE 719
+M+ +R + VS +A + L AE
Sbjct: 632 -----------DMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIH 680
Query: 720 KLQVELETRIRGLEEALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGG 779
K + E ++ L R + +A +E+++ K + +L + +E S
Sbjct: 681 KAEHE---KLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSIT--- 734
Query: 780 GGGDTTQLRAALEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQR 839
+ Q+ L A +++ ++ S L+E AS ++ A+ + L EE+A A + +
Sbjct: 735 ---EHLQVITTLRTAAKEMEEKISNLKE-HLASKEVEVAKLEKQLLEEKAAMTDAMVPRS 790
Query: 840 EEARLEQSRELEV------LREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACE 893
+L+ S E EV L+E + + +E+ + + E L + +
Sbjct: 791 SYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQ 850
Query: 894 EARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAE 953
E + L + ++A E L + A +L+E+ ++++ KE +L+
Sbjct: 851 EVNELLQKFQQAQEELAEMKRYAESSSKLEEDK----------DKKINEMSKEVTKLKEA 900
Query: 954 LERERVCSVALSEHER---IVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMK 1010
L S + S +R + LQ V QL+ QL E ++H+ EV V R L
Sbjct: 901 LNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQ----EVISVYRMHLLYA 956
Query: 1011 SERHAAEAQLATAEQQLRGLRTEAER 1036
+ E +Q L + ++++
Sbjct: 957 VQGQMDEDVQKVLKQILTMCKNQSQK 982
Score = 157 bits (397), Expect = 5e-38
Identities = 131/454 (28%), Positives = 222/454 (48%), Gaps = 39/454 (8%)
Query: 724 ELETRIRGLEEALRQRER--EAAAELEAALGKCEAAEAEAGR-LRERVREAEGSGASGGG 780
E+ + L+ AL + ER E ELE L E E G ++ V E E +S
Sbjct: 534 EINVLKQDLQNALEESERNKEKVRELEEKL-----VEREKGTVIKPPVEEYEEMKSSYCS 588
Query: 781 GGDTTQLRAAL-----EQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAE 835
+ A ++A+E++ L+ A DEA + L +
Sbjct: 589 VIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQ 647
Query: 836 LAQREEARLEQSRELEVLREQLATARATGEQQRTAAAE-----LGRARDAAEARVAELPA 890
+++ + E ELE R++ + T E A E +R AE ++E+ +
Sbjct: 648 VSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKS 707
Query: 891 ACEEARQGLAELREASEALRQSVVPASEHRR----LQEEALELRGRAASLEQEVVATGKE 946
+ L +L++ +A +++ V +EH + L+ A E+ + ++L++ + + E
Sbjct: 708 QYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVE 767
Query: 947 AARLRAELERERVCS----VALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQV 1002
A+L +L E+ V S +E++ +L++ V+ L +L+E + EK +EV Q+
Sbjct: 768 VAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQI 827
Query: 1003 QREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQA---QSRAQEALDKAKE-KDKKI 1058
+ E +K E+ + L + EQ++ L + ++A++ R E+ K +E KDKKI
Sbjct: 828 RSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKI 887
Query: 1059 TELSKEVFNLKEALKE--------QPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVA 1110
E+SKEV LKEAL + + ++EAL+ QVK LQ QL E + H V++
Sbjct: 888 NEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVIS 947
Query: 1111 LYRSHLLYAIQGQMDEDVQRILSQILQMQRLQAQ 1144
+YR HLLYA+QGQMDEDVQ++L QIL M + Q+Q
Sbjct: 948 VYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQ 981
Score = 30.8 bits (68), Expect = 7.7
Identities = 33/133 (24%), Positives = 64/133 (48%), Gaps = 12/133 (9%)
Query: 978 VAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERA 1037
+ QL+ L++L +R E + AE Q+Q E ++S R AE + +++
Sbjct: 434 IQQLQEILQDLQKRLESSEAERKQLQVE---LQSRR--AELVCLNNTEISENSSDLSQKL 488
Query: 1038 RQAQSRAQEALDK--AKEKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQ 1095
++ QS+ +EA+ + + +K K+ +S E + E + E+ L+ +DLQ
Sbjct: 489 KETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHE--LRVTEEEINVLK---QDLQ 543
Query: 1096 QQLQEAARDHSSV 1108
L+E+ R+ V
Sbjct: 544 NALEESERNKEKV 556
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 286 bits (732), Expect = 8e-77
Identities = 271/1033 (26%), Positives = 458/1033 (44%), Gaps = 102/1033 (9%)
Query: 41 QSQDWGKSDERLLQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEV 100
++ +W K+D+RLLQAVEN DA +VA+L+ +KG TK D EGK+AFHLAA +G CL V
Sbjct: 4 KTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRV 63
Query: 101 MIAHGSNVMSADGAGYNALHLAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAGGC 160
MI HG +V + D G++ALHLAAK H +C+++LLQ+ C + VDSSG TALH+AAA GC
Sbjct: 64 MITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGC 123
Query: 161 LSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALML 220
L ++LC K+ +N +D G PL++A Q H+++C LL GA N ++ GRTALML
Sbjct: 124 LQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALML 183
Query: 221 ACEGASPETVEVLLQGGAQPGITDALGQDAAHYGALAGD----KLILHLLQEAAQRPSPP 276
ACE S VE L++ GA + D+LG +A HY L+ + L+L + + A +P
Sbjct: 184 ACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPT 243
Query: 277 SALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRLRQERGRL 336
D + SS+ S G PKKRKAPPPP S D + I
Sbjct: 244 KPKQHDQVSKISSERS-------GTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKES 296
Query: 337 L--------QKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREV 388
+ +I + ++K+R + A SL + + + Q LL Q + SL
Sbjct: 297 VFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQ-QDLLSLLQAKVASLTLHN 355
Query: 389 ESLQSRL---SLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSAQEH-LASL 444
+ LQ +L S E E + + + Q + G PG + SPS H L
Sbjct: 356 KELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKS 415
Query: 445 QEQVAVLTRQNQELMEKVQ-ILENFEKDETQMEVEALAEVIPLALYDSLRAEFDQLRRQH 503
V +Q QE+++ +Q LE+ E + Q++VE + L ++ ++
Sbjct: 416 TTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNN-----TEISENS 470
Query: 504 AEALQALRQQETR-EVPREEGAACGESEVAGATATKNGPTHMELNGSVAPETKVNG-AET 561
++ Q L++ +++ E +E + + G + ++ + + E ++N +
Sbjct: 471 SDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQD 530
Query: 562 IDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEVREMETT--------- 612
+ E + + E E E K T KP E EM+++
Sbjct: 531 LQNALEESERNKEKVRELEEKLVER-------EKGTVIKPPVEEYEEMKSSYCSVIENMN 583
Query: 613 EEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTNM 672
+E+A + K AQ + + + + T+ ++EAE +M
Sbjct: 584 KEKAFLFEKYQEAQEEIMKLK--DTLKSQMTQEASDEAE-------------------DM 622
Query: 673 EATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIRGL 732
+ +R + VS +A + L AE K + E ++ L
Sbjct: 623 KEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHE---KLMQL 679
Query: 733 EEALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGDTTQLRAALE 792
R + +A +E+++ K + +L + +E S + Q+ L
Sbjct: 680 TNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSIT------EHLQVITTLR 733
Query: 793 QAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQSRELEV 852
A +++ ++ S L+E AS ++ A+ + L EE+A A + + +L+ S E EV
Sbjct: 734 TAAKEMEEKISNLKE-HLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEV 792
Query: 853 ------LREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREAS 906
L+E + + +E+ + + E L + +E + L + ++A
Sbjct: 793 SVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQ 852
Query: 907 EALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSE 966
E L + A +L+E+ ++++ KE +L+ L S + S
Sbjct: 853 EELAEMKRYAESSSKLEEDK----------DKKINEMSKEVTKLKEALNSLSQLSYSTSS 902
Query: 967 HER---IVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATA 1023
+R + LQ V QL+ QL E ++H+ EV V R L + E
Sbjct: 903 SKRQSQQLEALQQQVKQLQNQLAECKKQHQ----EVISVYRMHLLYAVQGQMDEDVQKVL 958
Query: 1024 EQQLRGLRTEAER 1036
+Q L + ++++
Sbjct: 959 KQILTMCKNQSQK 971
Score = 157 bits (397), Expect = 5e-38
Identities = 131/454 (28%), Positives = 222/454 (48%), Gaps = 39/454 (8%)
Query: 724 ELETRIRGLEEALRQRER--EAAAELEAALGKCEAAEAEAGR-LRERVREAEGSGASGGG 780
E+ + L+ AL + ER E ELE L E E G ++ V E E +S
Sbjct: 523 EINVLKQDLQNALEESERNKEKVRELEEKL-----VEREKGTVIKPPVEEYEEMKSSYCS 577
Query: 781 GGDTTQLRAAL-----EQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAE 835
+ A ++A+E++ L+ A DEA + L +
Sbjct: 578 VIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQ 636
Query: 836 LAQREEARLEQSRELEVLREQLATARATGEQQRTAAAE-----LGRARDAAEARVAELPA 890
+++ + E ELE R++ + T E A E +R AE ++E+ +
Sbjct: 637 VSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKS 696
Query: 891 ACEEARQGLAELREASEALRQSVVPASEHRR----LQEEALELRGRAASLEQEVVATGKE 946
+ L +L++ +A +++ V +EH + L+ A E+ + ++L++ + + E
Sbjct: 697 QYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVE 756
Query: 947 AARLRAELERERVCS----VALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQV 1002
A+L +L E+ V S +E++ +L++ V+ L +L+E + EK +EV Q+
Sbjct: 757 VAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQI 816
Query: 1003 QREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQA---QSRAQEALDKAKE-KDKKI 1058
+ E +K E+ + L + EQ++ L + ++A++ R E+ K +E KDKKI
Sbjct: 817 RSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKI 876
Query: 1059 TELSKEVFNLKEALKE--------QPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVA 1110
E+SKEV LKEAL + + ++EAL+ QVK LQ QL E + H V++
Sbjct: 877 NEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVIS 936
Query: 1111 LYRSHLLYAIQGQMDEDVQRILSQILQMQRLQAQ 1144
+YR HLLYA+QGQMDEDVQ++L QIL M + Q+Q
Sbjct: 937 VYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQ 970
Score = 30.8 bits (68), Expect = 7.7
Identities = 33/133 (24%), Positives = 64/133 (48%), Gaps = 12/133 (9%)
Query: 978 VAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERA 1037
+ QL+ L++L +R E + AE Q+Q E ++S R AE + +++
Sbjct: 423 IQQLQEILQDLQKRLESSEAERKQLQVE---LQSRR--AELVCLNNTEISENSSDLSQKL 477
Query: 1038 RQAQSRAQEALDK--AKEKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQ 1095
++ QS+ +EA+ + + +K K+ +S E + E + E+ L+ +DLQ
Sbjct: 478 KETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHE--LRVTEEEINVLK---QDLQ 532
Query: 1096 QQLQEAARDHSSV 1108
L+E+ R+ V
Sbjct: 533 NALEESERNKEKV 545
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 286 bits (732), Expect = 8e-77
Identities = 271/1035 (26%), Positives = 458/1035 (44%), Gaps = 102/1035 (9%)
Query: 39 RRQSQDWGKSDERLLQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCL 98
+ + +W K+D+RLLQAVEN DA +VA+L+ +KG TK D EGK+AFHLAA +G CL
Sbjct: 10 KSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 69
Query: 99 EVMIAHGSNVMSADGAGYNALHLAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAG 158
VMI HG +V + D G++ALHLAAK H +C+++LLQ+ C + VDSSG TALH+AAA
Sbjct: 70 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 129
Query: 159 GCLSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTAL 218
GCL ++LC K+ +N +D G PL++A Q H+++C LL GA N ++ GRTAL
Sbjct: 130 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 189
Query: 219 MLACEGASPETVEVLLQGGAQPGITDALGQDAAHYGALAGD----KLILHLLQEAAQRPS 274
MLACE S VE L++ GA + D+LG +A HY L+ + L+L + + A +
Sbjct: 190 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 249
Query: 275 PPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRLRQERG 334
P D + SS+ S G PKKRKAPPPP S D + I
Sbjct: 250 PTKPKQHDQVSKISSERS-------GTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK 302
Query: 335 RLL--------QKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGR 386
+ +I + ++K+R + A SL + + + Q LL Q + SL
Sbjct: 303 ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQ-QDLLSLLQAKVASLTL 361
Query: 387 EVESLQSRL---SLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSAQEH-LA 442
+ LQ +L S E E + + + Q + G PG + SPS H L
Sbjct: 362 HNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLG 421
Query: 443 SLQEQVAVLTRQNQELMEKVQ-ILENFEKDETQMEVEALAEVIPLALYDSLRAEFDQLRR 501
V +Q QE+++ +Q LE+ E + Q++VE + L ++ ++
Sbjct: 422 KSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNN-----TEISE 476
Query: 502 QHAEALQALRQQETR-EVPREEGAACGESEVAGATATKNGPTHMELNGSVAPETKVNG-A 559
++ Q L++ +++ E +E + + G + ++ + + E ++N
Sbjct: 477 NSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLK 536
Query: 560 ETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEVREMETT------- 612
+ + E + + E E E K T KP E EM+++
Sbjct: 537 QDLQNALEESERNKEKVRELEEKLVER-------EKGTVIKPPVEEYEEMKSSYCSVIEN 589
Query: 613 --EEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTT 670
+E+A + K AQ + + + + T+ ++EAE
Sbjct: 590 MNKEKAFLFEKYQEAQEEIMKLK--DTLKSQMTQEASDEAE------------------- 628
Query: 671 NMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIR 730
+M+ +R + VS +A + L AE K + E ++
Sbjct: 629 DMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHE---KLM 685
Query: 731 GLEEALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGDTTQLRAA 790
L R + +A +E+++ K + +L + +E S + Q+
Sbjct: 686 QLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSIT------EHLQVITT 739
Query: 791 LEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQSREL 850
L A +++ ++ S L+E AS ++ A+ + L EE+A A + + +L+ S E
Sbjct: 740 LRTAAKEMEEKISNLKE-HLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLES 798
Query: 851 EV------LREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELRE 904
EV L+E + + +E+ + + E L + +E + L + ++
Sbjct: 799 EVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQ 858
Query: 905 ASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSVAL 964
A E L + A +L+E+ ++++ KE +L+ L S +
Sbjct: 859 AQEELAEMKRYAESSSKLEEDK----------DKKINEMSKEVTKLKEALNSLSQLSYST 908
Query: 965 SEHER---IVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLA 1021
S +R + LQ V QL+ QL E ++H+ EV V R L + E
Sbjct: 909 SSSKRQSQQLEALQQQVKQLQNQLAECKKQHQ----EVISVYRMHLLYAVQGQMDEDVQK 964
Query: 1022 TAEQQLRGLRTEAER 1036
+Q L + ++++
Sbjct: 965 VLKQILTMCKNQSQK 979
Score = 157 bits (397), Expect = 5e-38
Identities = 131/454 (28%), Positives = 222/454 (48%), Gaps = 39/454 (8%)
Query: 724 ELETRIRGLEEALRQRER--EAAAELEAALGKCEAAEAEAGR-LRERVREAEGSGASGGG 780
E+ + L+ AL + ER E ELE L E E G ++ V E E +S
Sbjct: 531 EINVLKQDLQNALEESERNKEKVRELEEKL-----VEREKGTVIKPPVEEYEEMKSSYCS 585
Query: 781 GGDTTQLRAAL-----EQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAE 835
+ A ++A+E++ L+ A DEA + L +
Sbjct: 586 VIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQ 644
Query: 836 LAQREEARLEQSRELEVLREQLATARATGEQQRTAAAE-----LGRARDAAEARVAELPA 890
+++ + E ELE R++ + T E A E +R AE ++E+ +
Sbjct: 645 VSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKS 704
Query: 891 ACEEARQGLAELREASEALRQSVVPASEHRR----LQEEALELRGRAASLEQEVVATGKE 946
+ L +L++ +A +++ V +EH + L+ A E+ + ++L++ + + E
Sbjct: 705 QYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVE 764
Query: 947 AARLRAELERERVCS----VALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQV 1002
A+L +L E+ V S +E++ +L++ V+ L +L+E + EK +EV Q+
Sbjct: 765 VAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQI 824
Query: 1003 QREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQA---QSRAQEALDKAKE-KDKKI 1058
+ E +K E+ + L + EQ++ L + ++A++ R E+ K +E KDKKI
Sbjct: 825 RSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKI 884
Query: 1059 TELSKEVFNLKEALKE--------QPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVA 1110
E+SKEV LKEAL + + ++EAL+ QVK LQ QL E + H V++
Sbjct: 885 NEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVIS 944
Query: 1111 LYRSHLLYAIQGQMDEDVQRILSQILQMQRLQAQ 1144
+YR HLLYA+QGQMDEDVQ++L QIL M + Q+Q
Sbjct: 945 VYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQ 978
Score = 30.8 bits (68), Expect = 7.7
Identities = 33/133 (24%), Positives = 64/133 (48%), Gaps = 12/133 (9%)
Query: 978 VAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERA 1037
+ QL+ L++L +R E + AE Q+Q E ++S R AE + +++
Sbjct: 431 IQQLQEILQDLQKRLESSEAERKQLQVE---LQSRR--AELVCLNNTEISENSSDLSQKL 485
Query: 1038 RQAQSRAQEALDK--AKEKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQ 1095
++ QS+ +EA+ + + +K K+ +S E + E + E+ L+ +DLQ
Sbjct: 486 KETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHE--LRVTEEEINVLK---QDLQ 540
Query: 1096 QQLQEAARDHSSV 1108
L+E+ R+ V
Sbjct: 541 NALEESERNKEKV 553
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 286 bits (732), Expect = 8e-77
Identities = 271/1035 (26%), Positives = 458/1035 (44%), Gaps = 102/1035 (9%)
Query: 39 RRQSQDWGKSDERLLQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCL 98
+ + +W K+D+RLLQAVEN DA +VA+L+ +KG TK D EGK+AFHLAA +G CL
Sbjct: 10 KSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 69
Query: 99 EVMIAHGSNVMSADGAGYNALHLAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAG 158
VMI HG +V + D G++ALHLAAK H +C+++LLQ+ C + VDSSG TALH+AAA
Sbjct: 70 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 129
Query: 159 GCLSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTAL 218
GCL ++LC K+ +N +D G PL++A Q H+++C LL GA N ++ GRTAL
Sbjct: 130 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 189
Query: 219 MLACEGASPETVEVLLQGGAQPGITDALGQDAAHYGALAGD----KLILHLLQEAAQRPS 274
MLACE S VE L++ GA + D+LG +A HY L+ + L+L + + A +
Sbjct: 190 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 249
Query: 275 PPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRLRQERG 334
P D + SS+ S G PKKRKAPPPP S D + I
Sbjct: 250 PTKPKQHDQVSKISSERS-------GTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK 302
Query: 335 RLL--------QKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGR 386
+ +I + ++K+R + A SL + + + Q LL Q + SL
Sbjct: 303 ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQ-QDLLSLLQAKVASLTL 361
Query: 387 EVESLQSRL---SLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSAQEH-LA 442
+ LQ +L S E E + + + Q + G PG + SPS H L
Sbjct: 362 HNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLG 421
Query: 443 SLQEQVAVLTRQNQELMEKVQ-ILENFEKDETQMEVEALAEVIPLALYDSLRAEFDQLRR 501
V +Q QE+++ +Q LE+ E + Q++VE + L ++ ++
Sbjct: 422 KSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNN-----TEISE 476
Query: 502 QHAEALQALRQQETR-EVPREEGAACGESEVAGATATKNGPTHMELNGSVAPETKVNG-A 559
++ Q L++ +++ E +E + + G + ++ + + E ++N
Sbjct: 477 NSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLK 536
Query: 560 ETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEVREMETT------- 612
+ + E + + E E E K T KP E EM+++
Sbjct: 537 QDLQNALEESERNKEKVRELEEKLVER-------EKGTVIKPPVEEYEEMKSSYCSVIEN 589
Query: 613 --EEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTT 670
+E+A + K AQ + + + + T+ ++EAE
Sbjct: 590 MNKEKAFLFEKYQEAQEEIMKLK--DTLKSQMTQEASDEAE------------------- 628
Query: 671 NMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIR 730
+M+ +R + VS +A + L AE K + E ++
Sbjct: 629 DMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHE---KLM 685
Query: 731 GLEEALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGDTTQLRAA 790
L R + +A +E+++ K + +L + +E S + Q+
Sbjct: 686 QLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSIT------EHLQVITT 739
Query: 791 LEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQSREL 850
L A +++ ++ S L+E AS ++ A+ + L EE+A A + + +L+ S E
Sbjct: 740 LRTAAKEMEEKISNLKE-HLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLES 798
Query: 851 EV------LREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELRE 904
EV L+E + + +E+ + + E L + +E + L + ++
Sbjct: 799 EVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQ 858
Query: 905 ASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSVAL 964
A E L + A +L+E+ ++++ KE +L+ L S +
Sbjct: 859 AQEELAEMKRYAESSSKLEEDK----------DKKINEMSKEVTKLKEALNSLSQLSYST 908
Query: 965 SEHER---IVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLA 1021
S +R + LQ V QL+ QL E ++H+ EV V R L + E
Sbjct: 909 SSSKRQSQQLEALQQQVKQLQNQLAECKKQHQ----EVISVYRMHLLYAVQGQMDEDVQK 964
Query: 1022 TAEQQLRGLRTEAER 1036
+Q L + ++++
Sbjct: 965 VLKQILTMCKNQSQK 979
Score = 157 bits (397), Expect = 5e-38
Identities = 131/454 (28%), Positives = 222/454 (48%), Gaps = 39/454 (8%)
Query: 724 ELETRIRGLEEALRQRER--EAAAELEAALGKCEAAEAEAGR-LRERVREAEGSGASGGG 780
E+ + L+ AL + ER E ELE L E E G ++ V E E +S
Sbjct: 531 EINVLKQDLQNALEESERNKEKVRELEEKL-----VEREKGTVIKPPVEEYEEMKSSYCS 585
Query: 781 GGDTTQLRAAL-----EQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAE 835
+ A ++A+E++ L+ A DEA + L +
Sbjct: 586 VIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQ 644
Query: 836 LAQREEARLEQSRELEVLREQLATARATGEQQRTAAAE-----LGRARDAAEARVAELPA 890
+++ + E ELE R++ + T E A E +R AE ++E+ +
Sbjct: 645 VSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKS 704
Query: 891 ACEEARQGLAELREASEALRQSVVPASEHRR----LQEEALELRGRAASLEQEVVATGKE 946
+ L +L++ +A +++ V +EH + L+ A E+ + ++L++ + + E
Sbjct: 705 QYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVE 764
Query: 947 AARLRAELERERVCS----VALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQV 1002
A+L +L E+ V S +E++ +L++ V+ L +L+E + EK +EV Q+
Sbjct: 765 VAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQI 824
Query: 1003 QREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQA---QSRAQEALDKAKE-KDKKI 1058
+ E +K E+ + L + EQ++ L + ++A++ R E+ K +E KDKKI
Sbjct: 825 RSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKI 884
Query: 1059 TELSKEVFNLKEALKE--------QPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVA 1110
E+SKEV LKEAL + + ++EAL+ QVK LQ QL E + H V++
Sbjct: 885 NEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVIS 944
Query: 1111 LYRSHLLYAIQGQMDEDVQRILSQILQMQRLQAQ 1144
+YR HLLYA+QGQMDEDVQ++L QIL M + Q+Q
Sbjct: 945 VYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQ 978
Score = 30.8 bits (68), Expect = 7.7
Identities = 33/133 (24%), Positives = 64/133 (48%), Gaps = 12/133 (9%)
Query: 978 VAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERA 1037
+ QL+ L++L +R E + AE Q+Q E ++S R AE + +++
Sbjct: 431 IQQLQEILQDLQKRLESSEAERKQLQVE---LQSRR--AELVCLNNTEISENSSDLSQKL 485
Query: 1038 RQAQSRAQEALDK--AKEKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQ 1095
++ QS+ +EA+ + + +K K+ +S E + E + E+ L+ +DLQ
Sbjct: 486 KETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHE--LRVTEEEINVLK---QDLQ 540
Query: 1096 QQLQEAARDHSSV 1108
L+E+ R+ V
Sbjct: 541 NALEESERNKEKV 553
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 286 bits (732), Expect = 8e-77
Identities = 271/1035 (26%), Positives = 458/1035 (44%), Gaps = 102/1035 (9%)
Query: 39 RRQSQDWGKSDERLLQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCL 98
+ + +W K+D+RLLQAVEN DA +VA+L+ +KG TK D EGK+AFHLAA +G CL
Sbjct: 10 KSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 69
Query: 99 EVMIAHGSNVMSADGAGYNALHLAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAG 158
VMI HG +V + D G++ALHLAAK H +C+++LLQ+ C + VDSSG TALH+AAA
Sbjct: 70 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 129
Query: 159 GCLSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTAL 218
GCL ++LC K+ +N +D G PL++A Q H+++C LL GA N ++ GRTAL
Sbjct: 130 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 189
Query: 219 MLACEGASPETVEVLLQGGAQPGITDALGQDAAHYGALAGD----KLILHLLQEAAQRPS 274
MLACE S VE L++ GA + D+LG +A HY L+ + L+L + + A +
Sbjct: 190 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 249
Query: 275 PPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRLRQERG 334
P D + SS+ S G PKKRKAPPPP S D + I
Sbjct: 250 PTKPKQHDQVSKISSERS-------GTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGK 302
Query: 335 RLL--------QKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGR 386
+ +I + ++K+R + A SL + + + Q LL Q + SL
Sbjct: 303 ESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQ-QDLLSLLQAKVASLTL 361
Query: 387 EVESLQSRL---SLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSAQEH-LA 442
+ LQ +L S E E + + + Q + G PG + SPS H L
Sbjct: 362 HNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLG 421
Query: 443 SLQEQVAVLTRQNQELMEKVQ-ILENFEKDETQMEVEALAEVIPLALYDSLRAEFDQLRR 501
V +Q QE+++ +Q LE+ E + Q++VE + L ++ ++
Sbjct: 422 KSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNN-----TEISE 476
Query: 502 QHAEALQALRQQETR-EVPREEGAACGESEVAGATATKNGPTHMELNGSVAPETKVNG-A 559
++ Q L++ +++ E +E + + G + ++ + + E ++N
Sbjct: 477 NSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLK 536
Query: 560 ETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEVREMETT------- 612
+ + E + + E E E K T KP E EM+++
Sbjct: 537 QDLQNALEESERNKEKVRELEEKLVER-------EKGTVIKPPVEEYEEMKSSYCSVIEN 589
Query: 613 --EEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTT 670
+E+A + K AQ + + + + T+ ++EAE
Sbjct: 590 MNKEKAFLFEKYQEAQEEIMKLK--DTLKSQMTQEASDEAE------------------- 628
Query: 671 NMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIR 730
+M+ +R + VS +A + L AE K + E ++
Sbjct: 629 DMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHE---KLM 685
Query: 731 GLEEALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGDTTQLRAA 790
L R + +A +E+++ K + +L + +E S + Q+
Sbjct: 686 QLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSIT------EHLQVITT 739
Query: 791 LEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQSREL 850
L A +++ ++ S L+E AS ++ A+ + L EE+A A + + +L+ S E
Sbjct: 740 LRTAAKEMEEKISNLKE-HLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLES 798
Query: 851 EV------LREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELRE 904
EV L+E + + +E+ + + E L + +E + L + ++
Sbjct: 799 EVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQ 858
Query: 905 ASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSVAL 964
A E L + A +L+E+ ++++ KE +L+ L S +
Sbjct: 859 AQEELAEMKRYAESSSKLEEDK----------DKKINEMSKEVTKLKEALNSLSQLSYST 908
Query: 965 SEHER---IVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLA 1021
S +R + LQ V QL+ QL E ++H+ EV V R L + E
Sbjct: 909 SSSKRQSQQLEALQQQVKQLQNQLAECKKQHQ----EVISVYRMHLLYAVQGQMDEDVQK 964
Query: 1022 TAEQQLRGLRTEAER 1036
+Q L + ++++
Sbjct: 965 VLKQILTMCKNQSQK 979
Score = 157 bits (397), Expect = 5e-38
Identities = 131/454 (28%), Positives = 222/454 (48%), Gaps = 39/454 (8%)
Query: 724 ELETRIRGLEEALRQRER--EAAAELEAALGKCEAAEAEAGR-LRERVREAEGSGASGGG 780
E+ + L+ AL + ER E ELE L E E G ++ V E E +S
Sbjct: 531 EINVLKQDLQNALEESERNKEKVRELEEKL-----VEREKGTVIKPPVEEYEEMKSSYCS 585
Query: 781 GGDTTQLRAAL-----EQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAE 835
+ A ++A+E++ L+ A DEA + L +
Sbjct: 586 VIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQ 644
Query: 836 LAQREEARLEQSRELEVLREQLATARATGEQQRTAAAE-----LGRARDAAEARVAELPA 890
+++ + E ELE R++ + T E A E +R AE ++E+ +
Sbjct: 645 VSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKS 704
Query: 891 ACEEARQGLAELREASEALRQSVVPASEHRR----LQEEALELRGRAASLEQEVVATGKE 946
+ L +L++ +A +++ V +EH + L+ A E+ + ++L++ + + E
Sbjct: 705 QYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVE 764
Query: 947 AARLRAELERERVCS----VALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQV 1002
A+L +L E+ V S +E++ +L++ V+ L +L+E + EK +EV Q+
Sbjct: 765 VAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQI 824
Query: 1003 QREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQA---QSRAQEALDKAKE-KDKKI 1058
+ E +K E+ + L + EQ++ L + ++A++ R E+ K +E KDKKI
Sbjct: 825 RSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKI 884
Query: 1059 TELSKEVFNLKEALKE--------QPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVA 1110
E+SKEV LKEAL + + ++EAL+ QVK LQ QL E + H V++
Sbjct: 885 NEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVIS 944
Query: 1111 LYRSHLLYAIQGQMDEDVQRILSQILQMQRLQAQ 1144
+YR HLLYA+QGQMDEDVQ++L QIL M + Q+Q
Sbjct: 945 VYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQ 978
Score = 30.8 bits (68), Expect = 7.7
Identities = 33/133 (24%), Positives = 64/133 (48%), Gaps = 12/133 (9%)
Query: 978 VAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERA 1037
+ QL+ L++L +R E + AE Q+Q E ++S R AE + +++
Sbjct: 431 IQQLQEILQDLQKRLESSEAERKQLQVE---LQSRR--AELVCLNNTEISENSSDLSQKL 485
Query: 1038 RQAQSRAQEALDK--AKEKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQ 1095
++ QS+ +EA+ + + +K K+ +S E + E + E+ L+ +DLQ
Sbjct: 486 KETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHE--LRVTEEEINVLK---QDLQ 540
Query: 1096 QQLQEAARDHSSV 1108
L+E+ R+ V
Sbjct: 541 NALEESERNKEKV 553
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 265 bits (677), Expect = 2e-70
Identities = 260/1025 (25%), Positives = 454/1025 (44%), Gaps = 111/1025 (10%)
Query: 39 RRQSQDWGKSDERLLQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCL 98
+ + +W K+D+RLLQAVEN DA +VA+L+ +KG TK D EGK+AFHLAA +G CL
Sbjct: 10 KSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECL 69
Query: 99 EVMIAHGSNVMSADGAGYNALHLAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAG 158
VMI HG +V + D G++ALHLAAK H +C+++LLQ+ C + VDSSG TALH+AAA
Sbjct: 70 RVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQ 129
Query: 159 GCLSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTAL 218
GCL ++LC K+ +N +D G PL++A Q H+++C LL GA N ++ GRTAL
Sbjct: 130 GCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTAL 189
Query: 219 MLACEGASPETVEVLLQGGAQPGITDALGQDAAHYGALAGDKLILHLL-----QEA-AQR 272
MLACE S VE L++ GA + D+LG +A HY L+ + I LL Q+A +
Sbjct: 190 MLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKT 249
Query: 273 PSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRLRQE 332
P+ P L+ + SS S++S G A PP + EI +R+
Sbjct: 250 PTKPKQLS-----DVSSPRSITSTPLSGKESVFFAEPPFKA-----------EISSIREN 293
Query: 333 RGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVESLQ 392
+ RL G + + E+ + L +L+ +V L E Q++ ++ + + +
Sbjct: 294 KDRLSDSTTGADSLLD-ISSEADQQDLLSLLQAKVASLTLHNKELQDKLQA--KSPKEAE 350
Query: 393 SRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSAQEHLASLQEQVAVLT 452
+ LS T + + E PD + +L L S ++ +Q
Sbjct: 351 ADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQ------- 403
Query: 453 RQNQELMEKVQ-ILENFEKDETQMEVEALAEVIPLALYDSLRAEFDQLRRQHAEALQALR 511
Q QE+++ +Q LE+ E + Q++VE + L ++ ++ ++ Q L+
Sbjct: 404 -QLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNN-----TEISENSSDLSQKLK 457
Query: 512 QQETR-EVPREEGAACGESEVAGATATKNGPTHMELNGSVAPETKVNG-AETIDEEAAGD 569
+ +++ E +E + + G + ++ + + E ++N + +
Sbjct: 458 ETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEES 517
Query: 570 ETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEVREMETT---------EEEANMET 620
E + + E E E K T KP E EM+++ +E+A +
Sbjct: 518 ERNKEKVRELEEKLVER-------EKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFE 570
Query: 621 KPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRAT 680
K AQ + + + + T+ ++EAE +M+ +R
Sbjct: 571 KYQEAQEEIMKLK--DTLKSQMTQEASDEAE-------------------DMKEAMNRMI 609
Query: 681 GMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIRGLEEALRQRE 740
+ VS +A + L AE K + E ++ L R +
Sbjct: 610 DELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHE---KLMQLTNVSRAKA 666
Query: 741 REAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGDTTQLRAALEQAREDLRD 800
+A +E+++ K + +L + +E S + Q+ L A +++ +
Sbjct: 667 EDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSIT------EHLQVITTLRTAAKEMEE 720
Query: 801 RDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQSRELEV------LR 854
+ S L+E AS ++ A+ + L EE+A A + + +L+ S E EV L+
Sbjct: 721 KISNLKE-HLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLK 779
Query: 855 EQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVV 914
E + + +E+ + + E L + +E + L + ++A E L +
Sbjct: 780 ESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKR 839
Query: 915 PASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHER---IV 971
A +L+E+ ++++ KE +L+ L S + S +R +
Sbjct: 840 YAESSSKLEEDK----------DKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQL 889
Query: 972 GTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLR 1031
LQ V QL+ QL E ++H+ EV V R L + E +Q L +
Sbjct: 890 EALQQQVKQLQNQLAECKKQHQ----EVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCK 945
Query: 1032 TEAER 1036
++++
Sbjct: 946 NQSQK 950
Score = 157 bits (397), Expect = 5e-38
Identities = 131/454 (28%), Positives = 222/454 (48%), Gaps = 39/454 (8%)
Query: 724 ELETRIRGLEEALRQRER--EAAAELEAALGKCEAAEAEAGR-LRERVREAEGSGASGGG 780
E+ + L+ AL + ER E ELE L E E G ++ V E E +S
Sbjct: 502 EINVLKQDLQNALEESERNKEKVRELEEKL-----VEREKGTVIKPPVEEYEEMKSSYCS 556
Query: 781 GGDTTQLRAAL-----EQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAE 835
+ A ++A+E++ L+ A DEA + L +
Sbjct: 557 VIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEAS-DEAEDMKEAMNRMIDELNKQ 615
Query: 836 LAQREEARLEQSRELEVLREQLATARATGEQQRTAAAE-----LGRARDAAEARVAELPA 890
+++ + E ELE R++ + T E A E +R AE ++E+ +
Sbjct: 616 VSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKS 675
Query: 891 ACEEARQGLAELREASEALRQSVVPASEHRR----LQEEALELRGRAASLEQEVVATGKE 946
+ L +L++ +A +++ V +EH + L+ A E+ + ++L++ + + E
Sbjct: 676 QYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVE 735
Query: 947 AARLRAELERERVCS----VALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQV 1002
A+L +L E+ V S +E++ +L++ V+ L +L+E + EK +EV Q+
Sbjct: 736 VAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQI 795
Query: 1003 QREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQA---QSRAQEALDKAKE-KDKKI 1058
+ E +K E+ + L + EQ++ L + ++A++ R E+ K +E KDKKI
Sbjct: 796 RSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKI 855
Query: 1059 TELSKEVFNLKEALKE--------QPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVA 1110
E+SKEV LKEAL + + ++EAL+ QVK LQ QL E + H V++
Sbjct: 856 NEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVIS 915
Query: 1111 LYRSHLLYAIQGQMDEDVQRILSQILQMQRLQAQ 1144
+YR HLLYA+QGQMDEDVQ++L QIL M + Q+Q
Sbjct: 916 VYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQ 949
Score = 30.8 bits (68), Expect = 7.7
Identities = 33/133 (24%), Positives = 64/133 (48%), Gaps = 12/133 (9%)
Query: 978 VAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERA 1037
+ QL+ L++L +R E + AE Q+Q E ++S R AE + +++
Sbjct: 402 IQQLQEILQDLQKRLESSEAERKQLQVE---LQSRR--AELVCLNNTEISENSSDLSQKL 456
Query: 1038 RQAQSRAQEALDK--AKEKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQ 1095
++ QS+ +EA+ + + +K K+ +S E + E + E+ L+ +DLQ
Sbjct: 457 KETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHE--LRVTEEEINVLK---QDLQ 511
Query: 1096 QQLQEAARDHSSV 1108
L+E+ R+ V
Sbjct: 512 NALEESERNKEKV 524
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 261 bits (667), Expect = 3e-69
Identities = 264/1171 (22%), Positives = 497/1171 (42%), Gaps = 126/1171 (10%)
Query: 1 MKTLRARFKKTELRLSPTDLGSCPPCGPCPIPKPAARGRRQSQDWGKSDERLLQAVENND 60
MK+L++R ++ ++ P P AA + DW K D+RL++A E D
Sbjct: 1 MKSLKSRLRRQDV--------------PGPASSGAAAASAHAADWNKYDDRLMKAAERGD 46
Query: 61 APRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMIAHGSNVMSADGAGYNALH 120
+V +++A+KG+ P KLD EG+S FH+ +G CL ++ HG ++ ++D AG NALH
Sbjct: 47 VEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLNAILIHGVDITTSDTAGRNALH 106
Query: 121 LAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAGGCLSCSEVLCSFKAHLNPQDRS 180
LAAKYGH CL++LLQ +C + D G TALH AA C S ++LC A +N +D
Sbjct: 107 LAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDVD 166
Query: 181 GATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALMLACEGASPETVEVLLQGGAQP 240
G TPL++A QM +C+LL+ +GA N +D Q RTALML CE + VEVL++ GA
Sbjct: 167 GRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLIKNGADI 226
Query: 241 GITDALGQDAAHYGALAGDKLILHLLQEAAQRPSPPSALTEDDSGEASSQNSMSSHGKQG 300
+ DALG D+++Y + + IL LL+ A++ + L + G + Q +++ +
Sbjct: 227 SLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGRELWK--KGPSLQQRNLTHMQDEV 284
Query: 301 APKKRKAPPPPASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSL 360
K + ++ D E + +++QE+ LL K+ GL+ Q + E
Sbjct: 285 NVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQ------LQLNEEVMVA 338
Query: 361 HILERQVQELQQLLVERQEEKESLGREVESLQSRLSLLENER-------ENTSYDVTTLQ 413
LE + ++L+ LL ++++ E R +E+L++R E++ N D+ Q
Sbjct: 339 DDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQ 398
Query: 414 ------DEEGELPDLPG----------------------------AEVLLSRQLSPSAQE 439
D + P +P E+ R SA++
Sbjct: 399 GQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYSENEILKKELEAMRTFCESAKQ 458
Query: 440 HLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIPLALYDS------LR 493
LQ ++A + + L + + ++ + DE ++E + + +Y+S ++
Sbjct: 459 DRLKLQNELAHKVAECKALALECERVKE-DSDEQIKQLEDALKDVQKRMYESEGKVKQMQ 517
Query: 494 AEFDQLRRQHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTHMELNGSVAPE 553
F L+ + + T E+ + + E A A K ++ N + E
Sbjct: 518 THFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKL-RNQIKQNEMIVEE 576
Query: 554 TKVNGAETIDEEAAGDETMEARTMEAEATGAEAT----GAEATGAKVTETKPT------- 602
K + + I+E + + ME E G + T A+ AK+ + P
Sbjct: 577 FKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMK 636
Query: 603 ---GAEVRE--METTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGV 657
EV E + E E E + + E V+A + K + E
Sbjct: 637 SSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQ 696
Query: 658 GAGQAEPPVTGTTNMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEA 717
+G+ +T T T + + ++N ++ ++ H +
Sbjct: 697 KSGELGKKITELTLKNQTLQKE-------IEKVYLDNKLLKEQAHNLTIEMKNHYVPLKV 749
Query: 718 SEKLQVELETRIRGLEEAL---RQREREAAAELEAALGKCEAAEAEAGRLRE-RVREAEG 773
SE ++ + I L L Q+ E E+E L + ++ + RL V +
Sbjct: 750 SEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKH 809
Query: 774 SGASGGGGGDTTQLRAALEQAREDLRDRDSRLRELEAASACLDEARASRLLA----EEEA 829
+ +L+ L + ++ + ++ L + + L + +++ + EE
Sbjct: 810 EKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVK 869
Query: 830 RGLRAELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELP 889
L LA+ L+ ++ E + ++ + E + A +AE
Sbjct: 870 MTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHE 929
Query: 890 AACEEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAAR 949
A Q + ++++++ + + +R+ QEE + +L E+ A KE
Sbjct: 930 AKMSSLSQSMRKVQDSNAEI------LANYRKGQEEIV-------TLHAEIKAQKKELDT 976
Query: 950 LRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFM 1009
++ ++ + V+ E ER +A +L+ QL E +++ + EV +
Sbjct: 977 IQECIKVKYAPIVSFEECER---KFKATEKELKDQLSEQTQKYSVSEEEVKK-------N 1026
Query: 1010 KSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLK 1069
K E + ++ T ++ LR E++ + + D+ ++ K +++ EV N+K
Sbjct: 1027 KQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVK 1086
Query: 1070 EALKEQPAALATPEVEALRDQVKDLQQQLQE 1100
E L E+ A T E+ A+++ ++ L++
Sbjct: 1087 EKLVEENAK-QTSEILAVQNLLQKQHVPLEQ 1116
Score = 128 bits (321), Expect = 4e-29
Identities = 98/387 (25%), Positives = 183/387 (47%), Gaps = 32/387 (8%)
Query: 783 DTTQLRAALEQAREDLRDRD---SRLRELEAA-SACLDEARASRLLAEEEARGLRAELAQ 838
+ +L+ + ++DLRD+ + E+E A S DE ++ ++ +
Sbjct: 1029 ENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEK 1088
Query: 839 REEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQG 898
E +Q+ E+ ++ L EQ L + + + + E+ +Q
Sbjct: 1089 LVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQT 1148
Query: 899 LAELREASEALRQSVVPASEHRRLQE----EALELRGRAASLEQEVVATGKEAARLRAEL 954
+ +L + E + S VP +EH +++E E ++ E+E +E ++L++E+
Sbjct: 1149 VTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEV 1208
Query: 955 ERERVCS--------VALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREA 1006
+ + V LS+++ L+ ++ L +L L R++E+ EV +++
Sbjct: 1209 QNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKE 1268
Query: 1007 LFMKSERHAAEAQLATAEQQLRGLRTEAERA----RQAQSRAQEALDKAKEKDKKITELS 1062
+ K E+ + EQ+++ + +++ + Q R QE+ + + KD KITEL
Sbjct: 1269 ISAKDEKELLHFSI---EQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELL 1325
Query: 1063 KEVFNLKEALKE---------QPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYR 1113
+V LK+AL P + ++ L+ QVK L+QQL +A R H V+A+YR
Sbjct: 1326 NDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYR 1385
Query: 1114 SHLLYAIQGQMDEDVQRILSQILQMQR 1140
+HLL A QG MDEDVQ L QI+QM++
Sbjct: 1386 THLLSAAQGHMDEDVQEALLQIIQMRQ 1412
Score = 41.6 bits (96), Expect = 0.004
Identities = 54/225 (24%), Positives = 106/225 (47%), Gaps = 24/225 (10%)
Query: 336 LLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVESLQSRL 395
L ++++ +++ E+ QQ + LH L + L E + KE+ +EV +++ L
Sbjct: 1131 LKEELKSMQRCYEKEQQT---VTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASL 1187
Query: 396 SLLENERENTSYDVTTLQDE----EGELPDLPGAEVL-LSRQLSPSA--QEHLASLQEQV 448
E E +N +V+ LQ E + L L EV+ LS+ + + + ++SL E++
Sbjct: 1188 REKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKL 1247
Query: 449 AVLTRQNQELMEKVQILENFE---KDETQMEVEALAEVI--PLALYDSLRAEFDQLRRQH 503
A L R+ +E+ E+V + E KDE ++ ++ + I D +L+R+
Sbjct: 1248 ANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRI 1307
Query: 504 AEALQALRQQETR------EVPREEGAACGESEVAGATATKNGPT 542
E+ + + ++ + +V R + A G S++ T T PT
Sbjct: 1308 QESAKQIEAKDNKITELLNDVERLKQALNGLSQL---TYTSGNPT 1349
Score = 38.1 bits (87), Expect = 0.048
Identities = 70/339 (20%), Positives = 127/339 (37%), Gaps = 72/339 (21%)
Query: 791 LEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEA----------RGLRAELAQRE 840
LE EDL++R ++++ + LD+ +L EE L++ LA +E
Sbjct: 299 LEIENEDLKERLRKIQQEQRI--LLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKE 356
Query: 841 EARLEQSRELEVLR--------EQLATARATGEQQRTAAAELGRARDAAEARVAELPAAC 892
+ E R +E L+ + L + ++ + G+ A + A
Sbjct: 357 KQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAH 416
Query: 893 EEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRA 952
++R L L E S SE+ L++E +R S +Q+ + E A A
Sbjct: 417 MQSRSMLRPL----ELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVA 472
Query: 953 ELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSE 1012
E C E ER+ + QLE L+++ +R ++ +V Q+Q L +K
Sbjct: 473 E------CKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALK-- 524
Query: 1013 RHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEAL 1072
+ +A + ++TE LK+ L
Sbjct: 525 --------------------------------EHLTSEAASGNHRLTE------ELKDQL 546
Query: 1073 KEQPAAL--ATPEVEALRDQVKDLQQQLQEAARDHSSVV 1109
K+ A+ EV LR+Q+K + ++E RD ++
Sbjct: 547 KDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLI 585
Score = 32.7 bits (73), Expect = 2.0
Identities = 38/175 (21%), Positives = 72/175 (41%), Gaps = 17/175 (9%)
Query: 329 LRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQ--EEKE---- 382
L + L +K+ L + E +E A I + +EL +E++ ++KE
Sbjct: 1236 LETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDK 1295
Query: 383 ------SLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLP---GAEVLLSRQL 433
L R ++ ++ +N+ DV L+ L L G QL
Sbjct: 1296 SLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQL 1355
Query: 434 SPSAQEHLASLQEQVAVLTRQNQELME--KVQILENFEKDETQMEVEALAEVIPL 486
+ Q + SL++Q+A RQ+QE++ + +L + + EAL ++I +
Sbjct: 1356 IDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQM 1410
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 257 bits (656), Expect = 5e-68
Identities = 257/1132 (22%), Positives = 483/1132 (42%), Gaps = 112/1132 (9%)
Query: 40 RQSQDWGKSDERLLQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLE 99
R + DW K D+RL++A E D +V +++A+KG+ P KLD EG+S FH+ +G CL
Sbjct: 13 RHAADWNKYDDRLMKAAERGDVEKVTSILAKKGVNPGKLDVEGRSVFHVVTSKGNLECLN 72
Query: 100 VMIAHGSNVMSADGAGYNALHLAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAGG 159
++ HG ++ ++D AG NALHLAAKYGH CL++LLQ +C + D G TALH AA
Sbjct: 73 AILIHGVDITTSDTAGRNALHLAAKYGHALCLQKLLQYNCPTEHADLQGRTALHDAAMAD 132
Query: 160 CLSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALM 219
C S ++LC A +N +D G TPL++A QM +C+LL+ +GA N +D Q RTALM
Sbjct: 133 CPSSIQLLCDHGASVNAKDVDGRTPLVLATQMSRPTICQLLIDRGADVNSRDKQNRTALM 192
Query: 220 LACEGASPETVEVLLQGGAQPGITDALGQDAAHYGALAGDKLILHLLQEAAQRPSPPSAL 279
L CE + VEVL++ GA + DALG D+++Y + + IL LL+ A++ + L
Sbjct: 193 LGCEYGCRDAVEVLIKNGADISLLDALGHDSSYYARIGDNLDILTLLKTASENTNKGREL 252
Query: 280 TEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRLRQERGRLLQK 339
+ G + Q +++ + K + ++ D E + +++QE+ LL K
Sbjct: 253 WK--KGPSLQQRNLTHMQDEVNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDK 310
Query: 340 IRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVESLQSRLSLLE 399
+ GL+ Q + E LE + ++L+ LL ++++ E R +E+L++R E
Sbjct: 311 VNGLQ------LQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFE 364
Query: 400 NER-------ENTSYDVTTLQ------DEEGELPDLPG---------------------- 424
++ N D+ Q D + P +P
Sbjct: 365 SDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLPSQTSYS 424
Query: 425 ------AEVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVE 478
E+ R SA++ LQ ++A + + L + + ++ + DE ++E
Sbjct: 425 ENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKE-DSDEQIKQLE 483
Query: 479 ALAEVIPLALYDS------LRAEFDQLRRQHAEALQALRQQETREVPREEGAACGESEVA 532
+ + +Y+S ++ F L+ + + T E+ + + E A
Sbjct: 484 DALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGA 543
Query: 533 GATATKNGPTHMELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEAT----G 588
A K ++ N + E K + + I+E + + ME E G + T
Sbjct: 544 SAEVGKL-RNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQ 602
Query: 589 AEATGAKVTETKPT----------GAEVRE--METTEEEANMETKPTGAQATDTETTGVE 636
A+ AK+ + P EV E + E E E + + E V+
Sbjct: 603 AKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVK 662
Query: 637 AMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRATGMESTGVSATGVENPG 696
A + K + E +G+ +T T T + + ++N
Sbjct: 663 AKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKE-------IEKVYLDNKL 715
Query: 697 VEATVPGISAGPILHPGAAEASEKLQVELETRIRGLEEAL---RQREREAAAELEAALGK 753
++ ++ H + SE ++ + I L L Q+ E E+E L +
Sbjct: 716 LKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLE 775
Query: 754 CEAAEAEAGRLRE-RVREAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRLRELEAAS 812
++ + RL V + + +L+ L + ++ + ++ L + +
Sbjct: 776 NDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSEN 835
Query: 813 ACLDEARASRLLA----EEEARGLRAELAQREEARLEQSRELEVLREQLATARATGEQQR 868
L + +++ + EE L LA+ L+ ++ E + ++ + E +
Sbjct: 836 TNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILK 895
Query: 869 TAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRRLQEEALE 928
A +AE A Q + ++++++ + + +R+ QEE +
Sbjct: 896 RNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEI------LANYRKGQEEIV- 948
Query: 929 LRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEEL 988
+L E+ A KE ++ ++ + V+ E ER +A +L+ QL E
Sbjct: 949 ------TLHAEIKAQKKELDTIQECIKVKYAPIVSFEECER---KFKATEKELKDQLSEQ 999
Query: 989 GRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEAL 1048
+++ + EV + K E + ++ T ++ LR E++ + +
Sbjct: 1000 TQKYSVSEEEVKK-------NKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKT 1052
Query: 1049 DKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQQQLQE 1100
D+ ++ K +++ EV N+KE L E+ A T E+ A+++ ++ L++
Sbjct: 1053 DELNKQLKDLSQKYTEVKNVKEKLVEENAK-QTSEILAVQNLLQKQHVPLEQ 1103
Score = 128 bits (321), Expect = 4e-29
Identities = 98/387 (25%), Positives = 183/387 (47%), Gaps = 32/387 (8%)
Query: 783 DTTQLRAALEQAREDLRDRD---SRLRELEAA-SACLDEARASRLLAEEEARGLRAELAQ 838
+ +L+ + ++DLRD+ + E+E A S DE ++ ++ +
Sbjct: 1016 ENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEK 1075
Query: 839 REEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQG 898
E +Q+ E+ ++ L EQ L + + + + E+ +Q
Sbjct: 1076 LVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQT 1135
Query: 899 LAELREASEALRQSVVPASEHRRLQE----EALELRGRAASLEQEVVATGKEAARLRAEL 954
+ +L + E + S VP +EH +++E E ++ E+E +E ++L++E+
Sbjct: 1136 VTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEV 1195
Query: 955 ERERVCS--------VALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREA 1006
+ + V LS+++ L+ ++ L +L L R++E+ EV +++
Sbjct: 1196 QNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKE 1255
Query: 1007 LFMKSERHAAEAQLATAEQQLRGLRTEAERA----RQAQSRAQEALDKAKEKDKKITELS 1062
+ K E+ + EQ+++ + +++ + Q R QE+ + + KD KITEL
Sbjct: 1256 ISAKDEKELLHFSI---EQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELL 1312
Query: 1063 KEVFNLKEALKE---------QPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYR 1113
+V LK+AL P + ++ L+ QVK L+QQL +A R H V+A+YR
Sbjct: 1313 NDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYR 1372
Query: 1114 SHLLYAIQGQMDEDVQRILSQILQMQR 1140
+HLL A QG MDEDVQ L QI+QM++
Sbjct: 1373 THLLSAAQGHMDEDVQEALLQIIQMRQ 1399
Score = 41.6 bits (96), Expect = 0.004
Identities = 54/225 (24%), Positives = 106/225 (47%), Gaps = 24/225 (10%)
Query: 336 LLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVESLQSRL 395
L ++++ +++ E+ QQ + LH L + L E + KE+ +EV +++ L
Sbjct: 1118 LKEELKSMQRCYEKEQQT---VTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASL 1174
Query: 396 SLLENERENTSYDVTTLQDE----EGELPDLPGAEVL-LSRQLSPSA--QEHLASLQEQV 448
E E +N +V+ LQ E + L L EV+ LS+ + + + ++SL E++
Sbjct: 1175 REKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKL 1234
Query: 449 AVLTRQNQELMEKVQILENFE---KDETQMEVEALAEVI--PLALYDSLRAEFDQLRRQH 503
A L R+ +E+ E+V + E KDE ++ ++ + I D +L+R+
Sbjct: 1235 ANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRI 1294
Query: 504 AEALQALRQQETR------EVPREEGAACGESEVAGATATKNGPT 542
E+ + + ++ + +V R + A G S++ T T PT
Sbjct: 1295 QESAKQIEAKDNKITELLNDVERLKQALNGLSQL---TYTSGNPT 1336
Score = 38.1 bits (87), Expect = 0.048
Identities = 70/339 (20%), Positives = 127/339 (37%), Gaps = 72/339 (21%)
Query: 791 LEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEA----------RGLRAELAQRE 840
LE EDL++R ++++ + LD+ +L EE L++ LA +E
Sbjct: 286 LEIENEDLKERLRKIQQEQRI--LLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKE 343
Query: 841 EARLEQSRELEVLR--------EQLATARATGEQQRTAAAELGRARDAAEARVAELPAAC 892
+ E R +E L+ + L + ++ + G+ A + A
Sbjct: 344 KQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAH 403
Query: 893 EEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRA 952
++R L L E S SE+ L++E +R S +Q+ + E A A
Sbjct: 404 MQSRSMLRPL----ELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVA 459
Query: 953 ELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSE 1012
E C E ER+ + QLE L+++ +R ++ +V Q+Q L +K
Sbjct: 460 E------CKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALK-- 511
Query: 1013 RHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEAL 1072
+ +A + ++TE LK+ L
Sbjct: 512 --------------------------------EHLTSEAASGNHRLTE------ELKDQL 533
Query: 1073 KEQPAAL--ATPEVEALRDQVKDLQQQLQEAARDHSSVV 1109
K+ A+ EV LR+Q+K + ++E RD ++
Sbjct: 534 KDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLI 572
Score = 32.7 bits (73), Expect = 2.0
Identities = 38/175 (21%), Positives = 72/175 (41%), Gaps = 17/175 (9%)
Query: 329 LRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQ--EEKE---- 382
L + L +K+ L + E +E A I + +EL +E++ ++KE
Sbjct: 1223 LETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDK 1282
Query: 383 ------SLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLP---GAEVLLSRQL 433
L R ++ ++ +N+ DV L+ L L G QL
Sbjct: 1283 SLTTITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQL 1342
Query: 434 SPSAQEHLASLQEQVAVLTRQNQELME--KVQILENFEKDETQMEVEALAEVIPL 486
+ Q + SL++Q+A RQ+QE++ + +L + + EAL ++I +
Sbjct: 1343 IDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQM 1397
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 234 bits (596), Expect = 5e-61
Identities = 279/1034 (26%), Positives = 424/1034 (41%), Gaps = 115/1034 (11%)
Query: 45 WGKSDERLLQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMIAH 104
W + D++LL+AV D RVAAL +RK PTKLD G+S FHLAA +G CL +++A+
Sbjct: 17 WNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHLAASKGLTECLTILLAN 76
Query: 105 GSNVMSADGAGYNALHLAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAGGCLSCS 164
G+++ S + G ALHLA PQC+K LLQ D VD+ + LH AA+ GC S
Sbjct: 77 GADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAENRSPLHWAASSGCASSV 136
Query: 165 EVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALMLACEG 224
+LC +A L+ D G TPL+IA+ H +C LLQ+GA N D ++AL+LACE
Sbjct: 137 LLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEK 196
Query: 225 ASPETVEVLLQGGAQPGITDALGQDAAHYGALAGDK-LILHLLQEAAQRPSPPSALTEDD 283
S E E+LL GA G D+ G DA HY DK L HL Q ++R L +
Sbjct: 197 GSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSRRRRGGQRLVQHP 256
Query: 284 SGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRLRQERGRLLQKIRGL 343
+ +SQ S S PK P +D D E R + E R +K+ L
Sbjct: 257 --DLASQASPSEPQAGSPPKSSWRAEPEEEQEEKEDEDPCSEEWRWKYEEER--RKVVRL 312
Query: 344 EQHKERRQQESPEASSLHI-LERQVQE-LQQLLVERQEEKESLGREVESLQSRLSLLENE 401
EQ ++ +E ++ ++ LE Q++E Q+L V E + G++ SL+ +E
Sbjct: 313 EQELVQKTEECKTQAAAYLDLENQIREQAQELGVLLSWEPRASGKQGSSLRPGGDGME-- 370
Query: 402 RENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEK 461
+ D+ L + EL A ++ L+P E A + Q V R E
Sbjct: 371 -QGCPKDL--LAESTQELKKQQQAAATVNPVLAPKKAEDSAPGKIQYEVHGRSQPE---- 423
Query: 462 VQILENFEKDETQMEVEALAEVIPLALYDSLRAEFDQ-LRRQHAEALQALRQQETREVPR 520
E +E I A L Q HA+ L A +++ ++ +
Sbjct: 424 ----------EQGPPQSPASETIRKATGQQLTTNGAQTFGPDHADQLPAGQKESSQVLGV 473
Query: 521 EEGAACGESEVAGATATKNGPTHMELNGSVAPETKVNGA--ETIDEEAAGDETMEARTME 578
E G E A EL + GA + E A G T
Sbjct: 474 EPGGTVAEPVGPAAMNQLLLQLREELAAVWREKDAARGALSRPVMEGALG-------TPR 526
Query: 579 AEATGAEATGAEATGAKV---TETKPTGAEVREMETTEEEANMETKPTGAQATDTETTGV 635
AEA A EA +V E G +V+ ++E K E
Sbjct: 527 AEAAAAAWEKMEARLERVLARLEWAKAGLQVKPEVPSQESREGALKAAPGSIKQDEEKEK 586
Query: 636 EAMGVEATKTKAEEAEMQAYGVGAGQAEPP-----VTGTTNMEATG---------SRATG 681
G A E G+ GQ E ++ + +E G R
Sbjct: 587 RVPGARGEPLGALGGEKALGGLAKGQLEKEMSVLRLSNSNLLEELGELGRERQRLQRELQ 646
Query: 682 MESTGVSATGVENPGVEATVPGI--SAGPILHPGA--AEASEKLQVELETRIRGL----- 732
S + V P + + + S G + + A EA+EKL+ L ++ GL
Sbjct: 647 SLSQRLQREFVPKPEAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWD 706
Query: 733 --------EEALRQREREAAAELEAALGKCEAAEAEA----GRLRERVREAEGSGASGGG 780
E + + + E+ EL A + EA RL+E ++ GS +
Sbjct: 707 CLPADLVGERSAQSKAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCRE 766
Query: 781 GGDTTQLRAALEQA--REDLRDRDSRLRELEAASACLDE--ARASRLL--AEEEARGLR- 833
G + + A+ + A +DL + LR ++A + + + +LL A EE LR
Sbjct: 767 PGTSLKAPASPQVAALEQDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRA 826
Query: 834 ---AELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAA---EARVAE 887
A L Q E+ R + + ++L +A E+ TA E+GR R+A R +
Sbjct: 827 REAASLRQHEKTRGSLVAQAQAWGQEL---KALLEKYNTACREVGRLREAVAEERRRSGD 883
Query: 888 LPAACEEARQGLAELREASEALRQSVVPASEH--------RRLQEEALELRGRAASLEQE 939
L A E + +E+R SE ++ E R + + EL + L +E
Sbjct: 884 LAAQAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQLSEE 943
Query: 940 VVATGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQ-LEGQLEELGRRHEKTSAE 998
V+A E ARL +L+ + HE I+ T + ++ G +E E
Sbjct: 944 VLAIRGENARLALQLQDSQ------KNHEEIISTYRNHLLNAARGYMEH----------E 987
Query: 999 VFQVQREALFMKSE 1012
V+ + + L M+ E
Sbjct: 988 VYNILLQILSMEEE 1001
Score = 134 bits (337), Expect = 5e-31
Identities = 255/1091 (23%), Positives = 409/1091 (37%), Gaps = 236/1091 (21%)
Query: 144 VDSSGWTALHHAAAGGCLSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLCRLLLQQ 203
+DS+G + H AA+ G C +L + A +N ++ G+T L +A C ++LLQ
Sbjct: 50 LDSNGQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQH 109
Query: 204 GAAANDQDLQGRTALMLACEGASPETVEVLLQGGAQPGITDALGQDAAHYGALAGDKLIL 263
GA + D + R+ L A +V +L A + D G+ +L G I
Sbjct: 110 GANEDAVDAENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAIC 169
Query: 264 -HLLQEAAQ-----RPSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMP 317
LLQ A+ + + + + G A + SHG
Sbjct: 170 SQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHT 229
Query: 318 DDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVER 377
D+ + + + R R Q+ L QH + Q SP + + E
Sbjct: 230 QDKALWRHLQQALSRRRRGGQR---LVQHPDLASQASPSEPQAGSPPKSSWRAEP--EEE 284
Query: 378 QEEKESLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSA 437
QEEKE DE+ P +
Sbjct: 285 QEEKE-------------------------------DED------------------PCS 295
Query: 438 QEHLASLQEQVAVLTRQNQELMEKVQI----------LENFEKDETQMEVEALAEVIPLA 487
+E +E+ + R QEL++K + LEN +++ Q E+ L P A
Sbjct: 296 EEWRWKYEEERRKVVRLEQELVQKTEECKTQAAAYLDLENQIREQAQ-ELGVLLSWEPRA 354
Query: 488 LY---DSLRAEFDQLRRQHAEALQALRQQETREVPREEGAACGESEVAGATATKN---GP 541
SLR D + + + L A + T+E+ +++ AA + V ++ G
Sbjct: 355 SGKQGSSLRPGGDGMEQGCPKDLLA---ESTQELKKQQQAAATVNPVLAPKKAEDSAPGK 411
Query: 542 THMELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEAT--GAEATGAKVTET 599
E++G PE E ++ ET+ +ATG + T GA+ G +
Sbjct: 412 IQYEVHGRSQPE------EQGPPQSPASETIR------KATGQQLTTNGAQTFGPDHADQ 459
Query: 600 KPTGAEVREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGA 659
P G + E + +P G A E G AM + + E A +
Sbjct: 460 LPAGQK-------ESSQVLGVEPGGTVA---EPVGPAAMNQLLLQLREELAAVWR----- 504
Query: 660 GQAEPPVTGTTNMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASE 719
A G S V + P EA AA A E
Sbjct: 505 ---------------EKDAARGALSRPVMEGALGTPRAEA--------------AAAAWE 535
Query: 720 KLQVELETRIRGLE----------EALRQREREAAAELEAALGKCEAAEAEAGRLRERVR 769
K++ LE + LE E Q RE A L+AA G + E + +RV
Sbjct: 536 KMEARLERVLARLEWAKAGLQVKPEVPSQESREGA--LKAAPGSIKQDEEK----EKRVP 589
Query: 770 EAEGS--GASGG----GGGDTTQLRAA-----------LEQAREDLRDRDSRLRELEAAS 812
A G GA GG GG QL LE+ E R+R REL++ S
Sbjct: 590 GARGEPLGALGGEKALGGLAKGQLEKEMSVLRLSNSNLLEELGELGRERQRLQRELQSLS 649
Query: 813 ACLDEARASRLLAEEEARGLRAELAQREEARLEQSRELEVLREQLAT------------- 859
L + A+ + + LR + + E LR+ LA+
Sbjct: 650 QRLQREFVPKPEAQVQLQQLRQSVGLLTNELAMEKEATEKLRKLLASQSSGLRGLWDCLP 709
Query: 860 ARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEH 919
A GE R+A ++ + + A ++ L EA+Q LA L+E ++ LR S+ P E
Sbjct: 710 ADLVGE--RSAQSKAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCREP 767
Query: 920 R-------------------RLQEEALELRGRAASLEQEV-------VATGKEAARLRAE 953
+L+EE ++ + QE+ +E A LRA
Sbjct: 768 GTSLKAPASPQVAALEQDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVAELRA- 826
Query: 954 LERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSER 1013
RE + +L +HE+ G+L A +L+ L ++ EV ++ REA+ + R
Sbjct: 827 --RE---AASLRQHEKTRGSLVAQAQAWGQELKALLEKYNTACREVGRL-REAVAEERRR 880
Query: 1014 HA-AEAQLATAEQQLRGLRTEAER----ARQAQSRAQEALDKAKEKDKKITELSKEVFNL 1068
AQ A E+Q +R +E+ A + + + + ++K+ KI EL K++ L
Sbjct: 881 SGDLAAQAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLEQL 940
Query: 1069 KEALKEQPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDV 1128
E EV A+R + L QLQ++ ++H +++ YR+HLL A +G M+ +V
Sbjct: 941 SE------------EVLAIRGENARLALQLQDSQKNHEEIISTYRNHLLNAARGYMEHEV 988
Query: 1129 QRILSQILQMQ 1139
IL QIL M+
Sbjct: 989 YNILLQILSME 999
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 126 bits (316), Expect = 1e-28
Identities = 225/948 (23%), Positives = 364/948 (38%), Gaps = 165/948 (17%)
Query: 318 DDRDAYEEIVRLRQERGRLLQKIRGLEQHKER--RQQESPEASSLHILERQVQELQQLLV 375
D R Y E+ L + + + + + +ER QQ + E L +E +++ +QL
Sbjct: 1318 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE 1377
Query: 376 ERQEEKESLGREVESLQSRLSLLENERENTSYDVT----TLQDEEGELPDLPGAEVLLSR 431
+ K RE + LQ R+ RE + D ++Q+E +L AE+
Sbjct: 1378 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1437
Query: 432 QLSPSAQEHLASLQEQVAVL----------------------------TRQNQELMEKVQ 463
+ + +A+ ++E++ V+ Q ++ E+ +
Sbjct: 1438 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1497
Query: 464 ILENFEKDETQMEVEALAEVIPLALYDSLRAEFDQLRRQHAEALQALRQQETREVPREEG 523
L +DE+Q + +A E+ ++ A Q Q E L+ ++ R + + E
Sbjct: 1498 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1557
Query: 524 AACGESEVAGATATKNGPTHMELNGSVAPETKVNGAETIDEEAAG-----DETMEARTME 578
+ +VA TA ++ ++ + E ++ EE +E +
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1617
Query: 579 AEATGA----------------EATGAEATGAKVTETKPTGAEVREMETTEEEANMETKP 622
AEA A EA +V + K E E +EEA E +
Sbjct: 1618 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ--AEAEKQKEEAEREARR 1675
Query: 623 TGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAE------PPVTGTTNMEATG 676
G + + + + + + + AE A A + E G +
Sbjct: 1676 RG--KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1733
Query: 677 SRATGMESTGVSATGVENPGVEATVPGISAG-PILHPGAAEA-------SEKLQVELE-- 726
++ +AT + +EA + + A +L A A SEK + LE
Sbjct: 1734 EELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792
Query: 727 -----------TRIRGL-EEALRQR---EREAA---AELEAALGKCEAAEAEAGRLRE-- 766
R+R L EEA RQR E +AA AE E L + AA EA RL+
Sbjct: 1793 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1852
Query: 767 ----RVREAEGSGASGGGGGDTTQLRAALEQA---REDLRDRDSRLR-----ELEAASAC 814
+ +EAE + Q R EQA + D+ +R ++LR ELE
Sbjct: 1853 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1912
Query: 815 LDEARASRLLAEEEARGLRAELAQREEARLEQSRELEVLREQLATARATGEQ-------Q 867
+++ R EEE L+A + + E EL +R + EQ Q
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 868 RTAAAELGRARDAAEARVAELPAACEE-ARQGLAELREASEALRQSVVPASEHRRLQEEA 926
R AAE R R AE RV + AA EE ARQ A L E E L+ V E RRL+E A
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKV---EEARRLRERA 2028
Query: 927 LELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHERIVGTLQAN---VAQLEG 983
+ R L Q EAA+ R + E + + + + TLQ + QL G
Sbjct: 2029 EQESARQLQLAQ-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2081
Query: 984 QLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRG----------LRTE 1033
+ E R E+ Q +REA + + AE +AE+Q + LR E
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141
Query: 1034 AE-------RARQAQSRAQEALDKAKEKDKKITE--------LSKEVFNLKEALKEQPAA 1078
AE +A QA R ++A D EK KK E + +E+ L+ L+E
Sbjct: 2142 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---- 2197
Query: 1079 LATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDE 1126
+ L ++++ L+ + EAAR S V L++++ QM+E
Sbjct: 2198 -TDHQKNLLDEELQRLKAEATEAARQRSQV-----EEELFSVRVQMEE 2239
Score = 107 bits (266), Expect = 8e-23
Identities = 226/919 (24%), Positives = 366/919 (39%), Gaps = 134/919 (14%)
Query: 257 AGDKLILHL-LQEAAQRPSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPP---- 311
A + L L L +E AQ+ S A E EA + ++ A ++R+
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697
Query: 312 ---ASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQ 368
A A +E++RLR E + Q+ + LE+ R Q+E+ A+ ++ Q
Sbjct: 1698 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT------QKRQ 1751
Query: 369 ELQQLLVERQEEKESLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVL 428
EL+ L + + E E L L S+ E R + L+ E G +L E
Sbjct: 1752 ELEAELAKVRAEMEVL------LASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAA 1804
Query: 429 LSRQLSPSAQEHLASLQEQVAVLTRQNQE----LMEKVQILENFEKDETQMEVEALAEVI 484
R L+ A+ +E A RQ E L EK+ + + +T+ E+ AL E
Sbjct: 1805 RLRALAEEAKRQRQLAEEDAA---RQRAEAERVLAEKLAAIGEATRLKTEAEI-ALKE-- 1858
Query: 485 PLALYDSLRAEFDQLRR-QHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTH 543
AE ++LRR EA Q R EE AA ++++
Sbjct: 1859 -------KEAENERLRRLAEDEAFQRRR--------LEEQAAQHKADI------------ 1891
Query: 544 MELNGSVAPETKVNGAETIDEEAAGDETM-EARTMEAEATGAEATGAEATGAKVTETKPT 602
+A K + +E ++ ++T+ + R +E E +A+ +A K
Sbjct: 1892 ---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1948
Query: 603 GAEVREMETT---EEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGA 659
G E T +E+A +E A + E EA E K+ AE +A A
Sbjct: 1949 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA---EERVQKSLAAEEEA----A 2001
Query: 660 GQAEPPVTGTTNMEATGSRATGMESTGVSATGVE-NPGVEATVPGISAGPILHPGAAEAS 718
Q + + ++A A + + + EA + A H A +
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 719 EKLQVELETRIRGLEEALRQREREAAAELEAALGKCEA---AEAEAGRLRERVREAEGSG 775
E+ EL+ ++ + L Q EA A AA EA AE EA + R +V EAE
Sbjct: 2062 EQ---ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2118
Query: 776 ASGGGGGDTTQLRAALEQAREDLRD--RDSRLRELEAASACLDEARASRLLAEEEARGLR 833
S + Q RA + A E LR R +A A L + +A+ AE E
Sbjct: 2119 QS---AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD--AEMEKHKKF 2173
Query: 834 AELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRAR-DAAEA-----RVAE 887
AE R++A++EQ EL LR QL T Q+ EL R + +A EA +V E
Sbjct: 2174 AEQTLRQKAQVEQ--ELTTLRLQL---EETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2228
Query: 888 LPAACEEARQGLAELREASEALRQSVV---PASEHRRLQEEALELRGRAASLEQEVVATG 944
+ + L++L+ EA ++++ + R LQEEA +++ A + VA
Sbjct: 2229 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA-A 2287
Query: 945 KEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQR 1004
+EAARLR E + AL+ EK E Q +
Sbjct: 2288 QEAARLRQLAEEDLAQQRALA---------------------------EKMLKEKMQAVQ 2320
Query: 1005 EALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDK-KITELSK 1063
EA +K+E + Q A++Q R L+ + E+ Q + + + E ++ + E+S
Sbjct: 2321 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380
Query: 1064 EVFNLKEALKEQPAALATPEVEA--LRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQ 1121
E LK + E A A E +A R Q +++ ++L V L ++ L +
Sbjct: 2381 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--LEIQR 2438
Query: 1122 GQMDEDVQRILSQILQMQR 1140
Q D D +R+ I +++R
Sbjct: 2439 QQSDHDAERLREAIAELER 2457
Score = 75.5 bits (184), Expect = 3e-13
Identities = 212/898 (23%), Positives = 350/898 (38%), Gaps = 137/898 (15%)
Query: 312 ASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQ 371
A + R E R R+E +QK E+ R+++ + E + L+ +V+E +
Sbjct: 1965 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE--EVERLKAKVEEAR 2022
Query: 372 QLLVE-RQEEKESLGREVESLQSRLSLLENE-----RENTSYDVTTLQDEEGELPDLPGA 425
+L QE L E+ Q RL E ++ TLQ E+ L L G
Sbjct: 2023 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG- 2081
Query: 426 EVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIP 485
E +R+ + A+E + + A RQ +E Q E E+ + + + +A AE
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAE--- 2136
Query: 486 LALYDSLRAEFDQLRRQHAEALQA-LRQQETREVPREEGAACGESEVAGATATKNGPTHM 544
LR E +Q + A+A QA LRQ++ + E+ + A T +
Sbjct: 2137 -----KLRKEAEQEAARRAQAEQAALRQKQAADAEMEK-----HKKFAEQTLRQKAQVEQ 2186
Query: 545 ELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGA 604
EL ++ ET ++ DE E + ++AEAT A ++ E +
Sbjct: 2187 ELT-----TLRLQLEETDHQKNLLDE--ELQRLKAEATEAARQRSQV------EEELFSV 2233
Query: 605 EVREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEP 664
V+ E ++ +A +E + D + T + EA K K E V A +A
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAAR 2292
Query: 665 PVTGTTNMEATGSRATGMESTGVSATGV-ENPGVEATVPGISAGPILHPGAA----EASE 719
+ + RA + V E ++A + L A E E
Sbjct: 2293 -LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2351
Query: 720 KLQVELETRIRGLE---EALRQREREAAAELE------AALGKCEA-AEAEAGRLRERVR 769
++ +L +G + EA RQR+ E +AE E A + + +A AE +A R R +
Sbjct: 2352 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR---K 2408
Query: 770 EAEGSGASGGGGGDTTQLRAALEQAREDLR---DRDS-RLRE----LEAASACLD-EARA 820
+AE G TQ + L Q E R D D+ RLRE LE L EA+
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2468
Query: 821 SRLLAEE-----------EARGLRAELAQREEARLEQSRELE--------VLREQLATAR 861
+L +EE E + L+ +++ L++ R +E + ++++A A+
Sbjct: 2469 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2528
Query: 862 ATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRR 921
E+Q+ ++ + R L A+ EEAR+ E E ++ + + RR
Sbjct: 2529 QLREEQQRQQQQMEQERQ-------RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2581
Query: 922 LQEEALELRGRAASLEQEVVATGKEAARLRAELE-RERVCSVALSEHERIVGTLQANVAQ 980
QEE L +E RLR +L+ E AL+ E + + A
Sbjct: 2582 QQEELL----------------AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2625
Query: 981 LEGQLEEL-GRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLR---GLRTEAER 1036
L + L G E F R + S + EA + +AE+ R G T E
Sbjct: 2626 LPNGRDALDGPAAEAEPEHSFDGLRRKV---SAQRLQEAGILSAEELQRLAQGHTTVDEL 2682
Query: 1037 ARQ------AQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVEA---- 1086
AR+ Q R+ A K ++K++ + L+ L AL E +A
Sbjct: 2683 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAA----LQRQLLSPGTALILLEAQAASGF 2738
Query: 1087 LRDQVKDLQQQLQEAARDHSSVVALYRSHLLY----AIQGQMDEDVQRILSQILQMQR 1140
L D V++ + + EA ++ VV H L A+ G D + +S MQ+
Sbjct: 2739 LLDPVRNRRLTVNEAVKE--GVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQK 2794
Score = 72.8 bits (177), Expect = 2e-12
Identities = 170/719 (23%), Positives = 267/719 (37%), Gaps = 77/719 (10%)
Query: 270 AQRPSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRL 329
A R +A E EA + S ++ A ++RKA +A R
Sbjct: 1969 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2028
Query: 330 RQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVE 389
QE R LQ L Q +++ ++ E + ++++ QELQQ L + Q + L E E
Sbjct: 2029 EQESARQLQ----LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2084
Query: 390 SLQSRLSLLENERENTSYDV--TTLQDEEGELPDLPGAEVLLSRQLSPSAQEHLASLQEQ 447
+ + E R + + Q EE E E +R + +A E L EQ
Sbjct: 2085 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144
Query: 448 VAV--------LTRQNQ----ELMEKVQILENFEKDETQMEVEALAEVIPLALYDSLRAE 495
A RQ Q E+ + + E + + Q+E E + L D +
Sbjct: 2145 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204
Query: 496 FDQ-LRRQHAEALQALRQQETRE-------VPREEGA---ACGESEVAGATATKNGPTHM 544
D+ L+R AEA +A RQ+ E V EE + A E+E T
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 545 ELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAK----VTETK 600
L A + K E A E R + E + AE + V E
Sbjct: 2265 FLQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2323
Query: 601 PTGAEV----REMETTEEEAN--METKPTGAQATDTETTGVEA-----------MGVEAT 643
AE ++ E +E+A E K AQ ET G + M EA
Sbjct: 2324 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383
Query: 644 KTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRATGME-STGVSATGVENPGVEATVP 702
+ K AEM A E E G + E +T T V+ ++
Sbjct: 2384 RLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2441
Query: 703 GISAGPILHPGAAEASEKLQVELETRIRGLE-EALRQREREAAAELEAALGKCEAAEAEA 761
A + A EK +++ E ++ L+ E ++ ++E + AL + +E ++
Sbjct: 2442 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2501
Query: 762 GRLRERVREAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRL-RELEAASACLDEARA 820
RER E E + + A +Q RE+ + + ++ +E + A ++EAR
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEV----AKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557
Query: 821 SRLLAEEEARGLRAELAQREEARLEQS-----------RELEVLREQLATARATGEQ--- 866
+ AEE R + EL Q E+ R +Q +L++L EQ A A E+
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617
Query: 867 -QRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRRLQE 924
Q A L RDA + AE A E + GL A ++ A E +RL +
Sbjct: 2618 SQVAATKTLPNGRDALDGPAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2674
Score = 72.4 bits (176), Expect = 2e-12
Identities = 77/298 (25%), Positives = 128/298 (42%), Gaps = 23/298 (7%)
Query: 838 QREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQ 897
+ EE EQ R E RE+LA A E+QR A +A+ AE EL +E
Sbjct: 1345 EEEERLAEQQRAEE--RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--- 1399
Query: 898 GLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERE 957
E+ EA +V + R +QEE +LR + + Q + A R R +E E
Sbjct: 1400 ---EVVRREEA---AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453
Query: 958 -RVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAA 1016
RV + L ER G + + L + EE + + E +++R+ + A
Sbjct: 1454 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513
Query: 1017 EAQLATAEQQLRGLRTEAERARQAQSRAQEALD----KAKEKDKKITELSKEVFNLKEAL 1072
E +LA+ ++ EAE AR+ Q RA +AL+ +A+E ++++ + E +
Sbjct: 1514 EVELASR------VKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566
Query: 1073 KEQPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDVQR 1130
E A E+++ R + QL+ + ++ VA R Q Q + + R
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1624
Score = 38.5 bits (88), Expect = 0.037
Identities = 76/332 (22%), Positives = 131/332 (39%), Gaps = 42/332 (12%)
Query: 786 QLRAALEQ-AREDLRDRD--SRLRELEAASACLDEARASRL---LAEEEARGLRAELAQR 839
QL +LEQ A+E+ R + S L+++ + RL L +E AR +A++
Sbjct: 967 QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ 1026
Query: 840 EEARLEQSRELEVLREQLATARATGEQQRTAAAELGRA---RDAAEARVAELPAACEEAR 896
++A+ E +E L + +A A E+ A R E + +L +
Sbjct: 1027 QKAQAE----VEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1082
Query: 897 QGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELER 956
L +L+ S +R A E R EE L+ + E+ AT +LRA+ E
Sbjct: 1083 IYLEKLKTISLVIR-GTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1141
Query: 957 ERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAA 1016
++ AL + R AQ G E L +RH + EV + + + A
Sbjct: 1142 QQPTFDALRDELR--------GAQEVG--ERLQQRHGERDVEVERWRERVAQLLERWQAV 1191
Query: 1017 EAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP 1076
AQ +++L L + R++ L A+ + +EQ
Sbjct: 1192 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR------------------QEQI 1233
Query: 1077 AALATPEVEALRDQVKDLQQQLQEAARDHSSV 1108
A+ + +A+R+Q++ Q L+E R V
Sbjct: 1234 QAMPLADSQAVREQLRQEQALLEEIERHGEKV 1265
Score = 37.7 bits (86), Expect = 0.063
Identities = 59/266 (22%), Positives = 101/266 (37%), Gaps = 45/266 (16%)
Query: 886 AELPAACEEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQ---EVVA 942
A+ + C+ L ++R EA V +E A E R A ++ EV
Sbjct: 976 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1035
Query: 943 TGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLE---------------- 986
GK ARL AE E+ +AL E TL++ + G+LE
Sbjct: 1036 LGKGVARLSAEAEKV----LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1091
Query: 987 -----------ELGRRHEK-------TSAEVFQVQREALFMKSERHAAEAQLATAE---Q 1025
E+ R HE+ A + +++ +K R AEAQ T +
Sbjct: 1092 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1151
Query: 1026 QLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVE 1085
+LRG + ER +Q +++ +E+ ++ E + V + + + L ++
Sbjct: 1152 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR-QLR 1210
Query: 1086 ALRDQVKDLQQQLQEAARDHSSVVAL 1111
R+ L LQ+A R + A+
Sbjct: 1211 YYRESADPLGAWLQDARRRQEQIQAM 1236
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 126 bits (316), Expect = 1e-28
Identities = 225/948 (23%), Positives = 364/948 (38%), Gaps = 165/948 (17%)
Query: 318 DDRDAYEEIVRLRQERGRLLQKIRGLEQHKER--RQQESPEASSLHILERQVQELQQLLV 375
D R Y E+ L + + + + + +ER QQ + E L +E +++ +QL
Sbjct: 1322 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE 1381
Query: 376 ERQEEKESLGREVESLQSRLSLLENERENTSYDVT----TLQDEEGELPDLPGAEVLLSR 431
+ K RE + LQ R+ RE + D ++Q+E +L AE+
Sbjct: 1382 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1441
Query: 432 QLSPSAQEHLASLQEQVAVL----------------------------TRQNQELMEKVQ 463
+ + +A+ ++E++ V+ Q ++ E+ +
Sbjct: 1442 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1501
Query: 464 ILENFEKDETQMEVEALAEVIPLALYDSLRAEFDQLRRQHAEALQALRQQETREVPREEG 523
L +DE+Q + +A E+ ++ A Q Q E L+ ++ R + + E
Sbjct: 1502 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1561
Query: 524 AACGESEVAGATATKNGPTHMELNGSVAPETKVNGAETIDEEAAG-----DETMEARTME 578
+ +VA TA ++ ++ + E ++ EE +E +
Sbjct: 1562 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1621
Query: 579 AEATGA----------------EATGAEATGAKVTETKPTGAEVREMETTEEEANMETKP 622
AEA A EA +V + K E E +EEA E +
Sbjct: 1622 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ--AEAEKQKEEAEREARR 1679
Query: 623 TGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAE------PPVTGTTNMEATG 676
G + + + + + + + AE A A + E G +
Sbjct: 1680 RG--KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1737
Query: 677 SRATGMESTGVSATGVENPGVEATVPGISAG-PILHPGAAEA-------SEKLQVELE-- 726
++ +AT + +EA + + A +L A A SEK + LE
Sbjct: 1738 EELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1796
Query: 727 -----------TRIRGL-EEALRQR---EREAA---AELEAALGKCEAAEAEAGRLRE-- 766
R+R L EEA RQR E +AA AE E L + AA EA RL+
Sbjct: 1797 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1856
Query: 767 ----RVREAEGSGASGGGGGDTTQLRAALEQA---REDLRDRDSRLR-----ELEAASAC 814
+ +EAE + Q R EQA + D+ +R ++LR ELE
Sbjct: 1857 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1916
Query: 815 LDEARASRLLAEEEARGLRAELAQREEARLEQSRELEVLREQLATARATGEQ-------Q 867
+++ R EEE L+A + + E EL +R + EQ Q
Sbjct: 1917 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1976
Query: 868 RTAAAELGRARDAAEARVAELPAACEE-ARQGLAELREASEALRQSVVPASEHRRLQEEA 926
R AAE R R AE RV + AA EE ARQ A L E E L+ V E RRL+E A
Sbjct: 1977 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKV---EEARRLRERA 2032
Query: 927 LELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHERIVGTLQAN---VAQLEG 983
+ R L Q EAA+ R + E + + + + TLQ + QL G
Sbjct: 2033 EQESARQLQLAQ-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2085
Query: 984 QLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRG----------LRTE 1033
+ E R E+ Q +REA + + AE +AE+Q + LR E
Sbjct: 2086 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2145
Query: 1034 AE-------RARQAQSRAQEALDKAKEKDKKITE--------LSKEVFNLKEALKEQPAA 1078
AE +A QA R ++A D EK KK E + +E+ L+ L+E
Sbjct: 2146 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---- 2201
Query: 1079 LATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDE 1126
+ L ++++ L+ + EAAR S V L++++ QM+E
Sbjct: 2202 -TDHQKNLLDEELQRLKAEATEAARQRSQV-----EEELFSVRVQMEE 2243
Score = 107 bits (266), Expect = 8e-23
Identities = 226/919 (24%), Positives = 366/919 (39%), Gaps = 134/919 (14%)
Query: 257 AGDKLILHL-LQEAAQRPSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPP---- 311
A + L L L +E AQ+ S A E EA + ++ A ++R+
Sbjct: 1642 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1701
Query: 312 ---ASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQ 368
A A +E++RLR E + Q+ + LE+ R Q+E+ A+ ++ Q
Sbjct: 1702 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT------QKRQ 1755
Query: 369 ELQQLLVERQEEKESLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVL 428
EL+ L + + E E L L S+ E R + L+ E G +L E
Sbjct: 1756 ELEAELAKVRAEMEVL------LASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAA 1808
Query: 429 LSRQLSPSAQEHLASLQEQVAVLTRQNQE----LMEKVQILENFEKDETQMEVEALAEVI 484
R L+ A+ +E A RQ E L EK+ + + +T+ E+ AL E
Sbjct: 1809 RLRALAEEAKRQRQLAEEDAA---RQRAEAERVLAEKLAAIGEATRLKTEAEI-ALKE-- 1862
Query: 485 PLALYDSLRAEFDQLRR-QHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTH 543
AE ++LRR EA Q R EE AA ++++
Sbjct: 1863 -------KEAENERLRRLAEDEAFQRRR--------LEEQAAQHKADI------------ 1895
Query: 544 MELNGSVAPETKVNGAETIDEEAAGDETM-EARTMEAEATGAEATGAEATGAKVTETKPT 602
+A K + +E ++ ++T+ + R +E E +A+ +A K
Sbjct: 1896 ---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1952
Query: 603 GAEVREMETT---EEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGA 659
G E T +E+A +E A + E EA E K+ AE +A A
Sbjct: 1953 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA---EERVQKSLAAEEEA----A 2005
Query: 660 GQAEPPVTGTTNMEATGSRATGMESTGVSATGVE-NPGVEATVPGISAGPILHPGAAEAS 718
Q + + ++A A + + + EA + A H A +
Sbjct: 2006 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2065
Query: 719 EKLQVELETRIRGLEEALRQREREAAAELEAALGKCEA---AEAEAGRLRERVREAEGSG 775
E+ EL+ ++ + L Q EA A AA EA AE EA + R +V EAE
Sbjct: 2066 EQ---ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2122
Query: 776 ASGGGGGDTTQLRAALEQAREDLRD--RDSRLRELEAASACLDEARASRLLAEEEARGLR 833
S + Q RA + A E LR R +A A L + +A+ AE E
Sbjct: 2123 QS---AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD--AEMEKHKKF 2177
Query: 834 AELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRAR-DAAEA-----RVAE 887
AE R++A++EQ EL LR QL T Q+ EL R + +A EA +V E
Sbjct: 2178 AEQTLRQKAQVEQ--ELTTLRLQL---EETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2232
Query: 888 LPAACEEARQGLAELREASEALRQSVV---PASEHRRLQEEALELRGRAASLEQEVVATG 944
+ + L++L+ EA ++++ + R LQEEA +++ A + VA
Sbjct: 2233 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA-A 2291
Query: 945 KEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQR 1004
+EAARLR E + AL+ EK E Q +
Sbjct: 2292 QEAARLRQLAEEDLAQQRALA---------------------------EKMLKEKMQAVQ 2324
Query: 1005 EALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDK-KITELSK 1063
EA +K+E + Q A++Q R L+ + E+ Q + + + E ++ + E+S
Sbjct: 2325 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2384
Query: 1064 EVFNLKEALKEQPAALATPEVEA--LRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQ 1121
E LK + E A A E +A R Q +++ ++L V L ++ L +
Sbjct: 2385 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--LEIQR 2442
Query: 1122 GQMDEDVQRILSQILQMQR 1140
Q D D +R+ I +++R
Sbjct: 2443 QQSDHDAERLREAIAELER 2461
Score = 75.5 bits (184), Expect = 3e-13
Identities = 212/898 (23%), Positives = 350/898 (38%), Gaps = 137/898 (15%)
Query: 312 ASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQ 371
A + R E R R+E +QK E+ R+++ + E + L+ +V+E +
Sbjct: 1969 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE--EVERLKAKVEEAR 2026
Query: 372 QLLVE-RQEEKESLGREVESLQSRLSLLENE-----RENTSYDVTTLQDEEGELPDLPGA 425
+L QE L E+ Q RL E ++ TLQ E+ L L G
Sbjct: 2027 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG- 2085
Query: 426 EVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIP 485
E +R+ + A+E + + A RQ +E Q E E+ + + + +A AE
Sbjct: 2086 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAE--- 2140
Query: 486 LALYDSLRAEFDQLRRQHAEALQA-LRQQETREVPREEGAACGESEVAGATATKNGPTHM 544
LR E +Q + A+A QA LRQ++ + E+ + A T +
Sbjct: 2141 -----KLRKEAEQEAARRAQAEQAALRQKQAADAEMEK-----HKKFAEQTLRQKAQVEQ 2190
Query: 545 ELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGA 604
EL ++ ET ++ DE E + ++AEAT A ++ E +
Sbjct: 2191 ELT-----TLRLQLEETDHQKNLLDE--ELQRLKAEATEAARQRSQV------EEELFSV 2237
Query: 605 EVREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEP 664
V+ E ++ +A +E + D + T + EA K K E V A +A
Sbjct: 2238 RVQMEELSKLKARIEAENRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAAR 2296
Query: 665 PVTGTTNMEATGSRATGMESTGVSATGV-ENPGVEATVPGISAGPILHPGAA----EASE 719
+ + RA + V E ++A + L A E E
Sbjct: 2297 -LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2355
Query: 720 KLQVELETRIRGLE---EALRQREREAAAELE------AALGKCEA-AEAEAGRLRERVR 769
++ +L +G + EA RQR+ E +AE E A + + +A AE +A R R +
Sbjct: 2356 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR---K 2412
Query: 770 EAEGSGASGGGGGDTTQLRAALEQAREDLR---DRDS-RLRE----LEAASACLD-EARA 820
+AE G TQ + L Q E R D D+ RLRE LE L EA+
Sbjct: 2413 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2472
Query: 821 SRLLAEE-----------EARGLRAELAQREEARLEQSRELE--------VLREQLATAR 861
+L +EE E + L+ +++ L++ R +E + ++++A A+
Sbjct: 2473 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2532
Query: 862 ATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRR 921
E+Q+ ++ + R L A+ EEAR+ E E ++ + + RR
Sbjct: 2533 QLREEQQRQQQQMEQERQ-------RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2585
Query: 922 LQEEALELRGRAASLEQEVVATGKEAARLRAELE-RERVCSVALSEHERIVGTLQANVAQ 980
QEE L +E RLR +L+ E AL+ E + + A
Sbjct: 2586 QQEELL----------------AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2629
Query: 981 LEGQLEEL-GRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLR---GLRTEAER 1036
L + L G E F R + S + EA + +AE+ R G T E
Sbjct: 2630 LPNGRDALDGPAAEAEPEHSFDGLRRKV---SAQRLQEAGILSAEELQRLAQGHTTVDEL 2686
Query: 1037 ARQ------AQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVEA---- 1086
AR+ Q R+ A K ++K++ + L+ L AL E +A
Sbjct: 2687 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAA----LQRQLLSPGTALILLEAQAASGF 2742
Query: 1087 LRDQVKDLQQQLQEAARDHSSVVALYRSHLLY----AIQGQMDEDVQRILSQILQMQR 1140
L D V++ + + EA ++ VV H L A+ G D + +S MQ+
Sbjct: 2743 LLDPVRNRRLTVNEAVKE--GVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQK 2798
Score = 72.8 bits (177), Expect = 2e-12
Identities = 170/719 (23%), Positives = 267/719 (37%), Gaps = 77/719 (10%)
Query: 270 AQRPSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRL 329
A R +A E EA + S ++ A ++RKA +A R
Sbjct: 1973 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2032
Query: 330 RQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVE 389
QE R LQ L Q +++ ++ E + ++++ QELQQ L + Q + L E E
Sbjct: 2033 EQESARQLQ----LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2088
Query: 390 SLQSRLSLLENERENTSYDV--TTLQDEEGELPDLPGAEVLLSRQLSPSAQEHLASLQEQ 447
+ + E R + + Q EE E E +R + +A E L EQ
Sbjct: 2089 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2148
Query: 448 VAV--------LTRQNQ----ELMEKVQILENFEKDETQMEVEALAEVIPLALYDSLRAE 495
A RQ Q E+ + + E + + Q+E E + L D +
Sbjct: 2149 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2208
Query: 496 FDQ-LRRQHAEALQALRQQETRE-------VPREEGA---ACGESEVAGATATKNGPTHM 544
D+ L+R AEA +A RQ+ E V EE + A E+E T
Sbjct: 2209 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268
Query: 545 ELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAK----VTETK 600
L A + K E A E R + E + AE + V E
Sbjct: 2269 FLQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2327
Query: 601 PTGAEV----REMETTEEEAN--METKPTGAQATDTETTGVEA-----------MGVEAT 643
AE ++ E +E+A E K AQ ET G + M EA
Sbjct: 2328 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2387
Query: 644 KTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRATGME-STGVSATGVENPGVEATVP 702
+ K AEM A E E G + E +T T V+ ++
Sbjct: 2388 RLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2445
Query: 703 GISAGPILHPGAAEASEKLQVELETRIRGLE-EALRQREREAAAELEAALGKCEAAEAEA 761
A + A EK +++ E ++ L+ E ++ ++E + AL + +E ++
Sbjct: 2446 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2505
Query: 762 GRLRERVREAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRL-RELEAASACLDEARA 820
RER E E + + A +Q RE+ + + ++ +E + A ++EAR
Sbjct: 2506 LLQRERFIEQEKAKLEQLFQDEV----AKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2561
Query: 821 SRLLAEEEARGLRAELAQREEARLEQS-----------RELEVLREQLATARATGEQ--- 866
+ AEE R + EL Q E+ R +Q +L++L EQ A A E+
Sbjct: 2562 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2621
Query: 867 -QRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRRLQE 924
Q A L RDA + AE A E + GL A ++ A E +RL +
Sbjct: 2622 SQVAATKTLPNGRDALDGPAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2678
Score = 72.4 bits (176), Expect = 2e-12
Identities = 77/298 (25%), Positives = 128/298 (42%), Gaps = 23/298 (7%)
Query: 838 QREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQ 897
+ EE EQ R E RE+LA A E+QR A +A+ AE EL +E
Sbjct: 1349 EEEERLAEQQRAEE--RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--- 1403
Query: 898 GLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERE 957
E+ EA +V + R +QEE +LR + + Q + A R R +E E
Sbjct: 1404 ---EVVRREEA---AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1457
Query: 958 -RVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAA 1016
RV + L ER G + + L + EE + + E +++R+ + A
Sbjct: 1458 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1517
Query: 1017 EAQLATAEQQLRGLRTEAERARQAQSRAQEALD----KAKEKDKKITELSKEVFNLKEAL 1072
E +LA+ ++ EAE AR+ Q RA +AL+ +A+E ++++ + E +
Sbjct: 1518 EVELASR------VKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVERARQVQVA 1570
Query: 1073 KEQPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDVQR 1130
E A E+++ R + QL+ + ++ VA R Q Q + + R
Sbjct: 1571 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1628
Score = 38.5 bits (88), Expect = 0.037
Identities = 76/332 (22%), Positives = 131/332 (39%), Gaps = 42/332 (12%)
Query: 786 QLRAALEQ-AREDLRDRD--SRLRELEAASACLDEARASRL---LAEEEARGLRAELAQR 839
QL +LEQ A+E+ R + S L+++ + RL L +E AR +A++
Sbjct: 971 QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ 1030
Query: 840 EEARLEQSRELEVLREQLATARATGEQQRTAAAELGRA---RDAAEARVAELPAACEEAR 896
++A+ E +E L + +A A E+ A R E + +L +
Sbjct: 1031 QKAQAE----VEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1086
Query: 897 QGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELER 956
L +L+ S +R A E R EE L+ + E+ AT +LRA+ E
Sbjct: 1087 IYLEKLKTISLVIR-GTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1145
Query: 957 ERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAA 1016
++ AL + R AQ G E L +RH + EV + + + A
Sbjct: 1146 QQPTFDALRDELR--------GAQEVG--ERLQQRHGERDVEVERWRERVAQLLERWQAV 1195
Query: 1017 EAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP 1076
AQ +++L L + R++ L A+ + +EQ
Sbjct: 1196 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR------------------QEQI 1237
Query: 1077 AALATPEVEALRDQVKDLQQQLQEAARDHSSV 1108
A+ + +A+R+Q++ Q L+E R V
Sbjct: 1238 QAMPLADSQAVREQLRQEQALLEEIERHGEKV 1269
Score = 37.7 bits (86), Expect = 0.063
Identities = 59/266 (22%), Positives = 101/266 (37%), Gaps = 45/266 (16%)
Query: 886 AELPAACEEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQ---EVVA 942
A+ + C+ L ++R EA V +E A E R A ++ EV
Sbjct: 980 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1039
Query: 943 TGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLE---------------- 986
GK ARL AE E+ +AL E TL++ + G+LE
Sbjct: 1040 LGKGVARLSAEAEKV----LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1095
Query: 987 -----------ELGRRHEK-------TSAEVFQVQREALFMKSERHAAEAQLATAE---Q 1025
E+ R HE+ A + +++ +K R AEAQ T +
Sbjct: 1096 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1155
Query: 1026 QLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVE 1085
+LRG + ER +Q +++ +E+ ++ E + V + + + L ++
Sbjct: 1156 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR-QLR 1214
Query: 1086 ALRDQVKDLQQQLQEAARDHSSVVAL 1111
R+ L LQ+A R + A+
Sbjct: 1215 YYRESADPLGAWLQDARRRQEQIQAM 1240
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 126 bits (316), Expect = 1e-28
Identities = 225/948 (23%), Positives = 364/948 (38%), Gaps = 165/948 (17%)
Query: 318 DDRDAYEEIVRLRQERGRLLQKIRGLEQHKER--RQQESPEASSLHILERQVQELQQLLV 375
D R Y E+ L + + + + + +ER QQ + E L +E +++ +QL
Sbjct: 1318 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE 1377
Query: 376 ERQEEKESLGREVESLQSRLSLLENERENTSYDVT----TLQDEEGELPDLPGAEVLLSR 431
+ K RE + LQ R+ RE + D ++Q+E +L AE+
Sbjct: 1378 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1437
Query: 432 QLSPSAQEHLASLQEQVAVL----------------------------TRQNQELMEKVQ 463
+ + +A+ ++E++ V+ Q ++ E+ +
Sbjct: 1438 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1497
Query: 464 ILENFEKDETQMEVEALAEVIPLALYDSLRAEFDQLRRQHAEALQALRQQETREVPREEG 523
L +DE+Q + +A E+ ++ A Q Q E L+ ++ R + + E
Sbjct: 1498 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1557
Query: 524 AACGESEVAGATATKNGPTHMELNGSVAPETKVNGAETIDEEAAG-----DETMEARTME 578
+ +VA TA ++ ++ + E ++ EE +E +
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1617
Query: 579 AEATGA----------------EATGAEATGAKVTETKPTGAEVREMETTEEEANMETKP 622
AEA A EA +V + K E E +EEA E +
Sbjct: 1618 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ--AEAEKQKEEAEREARR 1675
Query: 623 TGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAE------PPVTGTTNMEATG 676
G + + + + + + + AE A A + E G +
Sbjct: 1676 RG--KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1733
Query: 677 SRATGMESTGVSATGVENPGVEATVPGISAG-PILHPGAAEA-------SEKLQVELE-- 726
++ +AT + +EA + + A +L A A SEK + LE
Sbjct: 1734 EELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792
Query: 727 -----------TRIRGL-EEALRQR---EREAA---AELEAALGKCEAAEAEAGRLRE-- 766
R+R L EEA RQR E +AA AE E L + AA EA RL+
Sbjct: 1793 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1852
Query: 767 ----RVREAEGSGASGGGGGDTTQLRAALEQA---REDLRDRDSRLR-----ELEAASAC 814
+ +EAE + Q R EQA + D+ +R ++LR ELE
Sbjct: 1853 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1912
Query: 815 LDEARASRLLAEEEARGLRAELAQREEARLEQSRELEVLREQLATARATGEQ-------Q 867
+++ R EEE L+A + + E EL +R + EQ Q
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 868 RTAAAELGRARDAAEARVAELPAACEE-ARQGLAELREASEALRQSVVPASEHRRLQEEA 926
R AAE R R AE RV + AA EE ARQ A L E E L+ V E RRL+E A
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKV---EEARRLRERA 2028
Query: 927 LELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHERIVGTLQAN---VAQLEG 983
+ R L Q EAA+ R + E + + + + TLQ + QL G
Sbjct: 2029 EQESARQLQLAQ-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2081
Query: 984 QLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRG----------LRTE 1033
+ E R E+ Q +REA + + AE +AE+Q + LR E
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141
Query: 1034 AE-------RARQAQSRAQEALDKAKEKDKKITE--------LSKEVFNLKEALKEQPAA 1078
AE +A QA R ++A D EK KK E + +E+ L+ L+E
Sbjct: 2142 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---- 2197
Query: 1079 LATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDE 1126
+ L ++++ L+ + EAAR S V L++++ QM+E
Sbjct: 2198 -TDHQKNLLDEELQRLKAEATEAARQRSQV-----EEELFSVRVQMEE 2239
Score = 107 bits (266), Expect = 8e-23
Identities = 226/919 (24%), Positives = 366/919 (39%), Gaps = 134/919 (14%)
Query: 257 AGDKLILHL-LQEAAQRPSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPP---- 311
A + L L L +E AQ+ S A E EA + ++ A ++R+
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697
Query: 312 ---ASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQ 368
A A +E++RLR E + Q+ + LE+ R Q+E+ A+ ++ Q
Sbjct: 1698 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT------QKRQ 1751
Query: 369 ELQQLLVERQEEKESLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVL 428
EL+ L + + E E L L S+ E R + L+ E G +L E
Sbjct: 1752 ELEAELAKVRAEMEVL------LASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAA 1804
Query: 429 LSRQLSPSAQEHLASLQEQVAVLTRQNQE----LMEKVQILENFEKDETQMEVEALAEVI 484
R L+ A+ +E A RQ E L EK+ + + +T+ E+ AL E
Sbjct: 1805 RLRALAEEAKRQRQLAEEDAA---RQRAEAERVLAEKLAAIGEATRLKTEAEI-ALKE-- 1858
Query: 485 PLALYDSLRAEFDQLRR-QHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTH 543
AE ++LRR EA Q R EE AA ++++
Sbjct: 1859 -------KEAENERLRRLAEDEAFQRRR--------LEEQAAQHKADI------------ 1891
Query: 544 MELNGSVAPETKVNGAETIDEEAAGDETM-EARTMEAEATGAEATGAEATGAKVTETKPT 602
+A K + +E ++ ++T+ + R +E E +A+ +A K
Sbjct: 1892 ---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1948
Query: 603 GAEVREMETT---EEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGA 659
G E T +E+A +E A + E EA E K+ AE +A A
Sbjct: 1949 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA---EERVQKSLAAEEEA----A 2001
Query: 660 GQAEPPVTGTTNMEATGSRATGMESTGVSATGVE-NPGVEATVPGISAGPILHPGAAEAS 718
Q + + ++A A + + + EA + A H A +
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 719 EKLQVELETRIRGLEEALRQREREAAAELEAALGKCEA---AEAEAGRLRERVREAEGSG 775
E+ EL+ ++ + L Q EA A AA EA AE EA + R +V EAE
Sbjct: 2062 EQ---ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2118
Query: 776 ASGGGGGDTTQLRAALEQAREDLRD--RDSRLRELEAASACLDEARASRLLAEEEARGLR 833
S + Q RA + A E LR R +A A L + +A+ AE E
Sbjct: 2119 QS---AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD--AEMEKHKKF 2173
Query: 834 AELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRAR-DAAEA-----RVAE 887
AE R++A++EQ EL LR QL T Q+ EL R + +A EA +V E
Sbjct: 2174 AEQTLRQKAQVEQ--ELTTLRLQL---EETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2228
Query: 888 LPAACEEARQGLAELREASEALRQSVV---PASEHRRLQEEALELRGRAASLEQEVVATG 944
+ + L++L+ EA ++++ + R LQEEA +++ A + VA
Sbjct: 2229 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA-A 2287
Query: 945 KEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQR 1004
+EAARLR E + AL+ EK E Q +
Sbjct: 2288 QEAARLRQLAEEDLAQQRALA---------------------------EKMLKEKMQAVQ 2320
Query: 1005 EALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDK-KITELSK 1063
EA +K+E + Q A++Q R L+ + E+ Q + + + E ++ + E+S
Sbjct: 2321 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380
Query: 1064 EVFNLKEALKEQPAALATPEVEA--LRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQ 1121
E LK + E A A E +A R Q +++ ++L V L ++ L +
Sbjct: 2381 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--LEIQR 2438
Query: 1122 GQMDEDVQRILSQILQMQR 1140
Q D D +R+ I +++R
Sbjct: 2439 QQSDHDAERLREAIAELER 2457
Score = 75.5 bits (184), Expect = 3e-13
Identities = 212/898 (23%), Positives = 350/898 (38%), Gaps = 137/898 (15%)
Query: 312 ASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQ 371
A + R E R R+E +QK E+ R+++ + E + L+ +V+E +
Sbjct: 1965 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE--EVERLKAKVEEAR 2022
Query: 372 QLLVE-RQEEKESLGREVESLQSRLSLLENE-----RENTSYDVTTLQDEEGELPDLPGA 425
+L QE L E+ Q RL E ++ TLQ E+ L L G
Sbjct: 2023 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG- 2081
Query: 426 EVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIP 485
E +R+ + A+E + + A RQ +E Q E E+ + + + +A AE
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAE--- 2136
Query: 486 LALYDSLRAEFDQLRRQHAEALQA-LRQQETREVPREEGAACGESEVAGATATKNGPTHM 544
LR E +Q + A+A QA LRQ++ + E+ + A T +
Sbjct: 2137 -----KLRKEAEQEAARRAQAEQAALRQKQAADAEMEK-----HKKFAEQTLRQKAQVEQ 2186
Query: 545 ELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGA 604
EL ++ ET ++ DE E + ++AEAT A ++ E +
Sbjct: 2187 ELT-----TLRLQLEETDHQKNLLDE--ELQRLKAEATEAARQRSQV------EEELFSV 2233
Query: 605 EVREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEP 664
V+ E ++ +A +E + D + T + EA K K E V A +A
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAAR 2292
Query: 665 PVTGTTNMEATGSRATGMESTGVSATGV-ENPGVEATVPGISAGPILHPGAA----EASE 719
+ + RA + V E ++A + L A E E
Sbjct: 2293 -LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2351
Query: 720 KLQVELETRIRGLE---EALRQREREAAAELE------AALGKCEA-AEAEAGRLRERVR 769
++ +L +G + EA RQR+ E +AE E A + + +A AE +A R R +
Sbjct: 2352 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR---K 2408
Query: 770 EAEGSGASGGGGGDTTQLRAALEQAREDLR---DRDS-RLRE----LEAASACLD-EARA 820
+AE G TQ + L Q E R D D+ RLRE LE L EA+
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2468
Query: 821 SRLLAEE-----------EARGLRAELAQREEARLEQSRELE--------VLREQLATAR 861
+L +EE E + L+ +++ L++ R +E + ++++A A+
Sbjct: 2469 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2528
Query: 862 ATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRR 921
E+Q+ ++ + R L A+ EEAR+ E E ++ + + RR
Sbjct: 2529 QLREEQQRQQQQMEQERQ-------RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2581
Query: 922 LQEEALELRGRAASLEQEVVATGKEAARLRAELE-RERVCSVALSEHERIVGTLQANVAQ 980
QEE L +E RLR +L+ E AL+ E + + A
Sbjct: 2582 QQEELL----------------AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2625
Query: 981 LEGQLEEL-GRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLR---GLRTEAER 1036
L + L G E F R + S + EA + +AE+ R G T E
Sbjct: 2626 LPNGRDALDGPAAEAEPEHSFDGLRRKV---SAQRLQEAGILSAEELQRLAQGHTTVDEL 2682
Query: 1037 ARQ------AQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVEA---- 1086
AR+ Q R+ A K ++K++ + L+ L AL E +A
Sbjct: 2683 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAA----LQRQLLSPGTALILLEAQAASGF 2738
Query: 1087 LRDQVKDLQQQLQEAARDHSSVVALYRSHLLY----AIQGQMDEDVQRILSQILQMQR 1140
L D V++ + + EA ++ VV H L A+ G D + +S MQ+
Sbjct: 2739 LLDPVRNRRLTVNEAVKE--GVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQK 2794
Score = 72.8 bits (177), Expect = 2e-12
Identities = 170/719 (23%), Positives = 267/719 (37%), Gaps = 77/719 (10%)
Query: 270 AQRPSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRL 329
A R +A E EA + S ++ A ++RKA +A R
Sbjct: 1969 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2028
Query: 330 RQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVE 389
QE R LQ L Q +++ ++ E + ++++ QELQQ L + Q + L E E
Sbjct: 2029 EQESARQLQ----LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2084
Query: 390 SLQSRLSLLENERENTSYDV--TTLQDEEGELPDLPGAEVLLSRQLSPSAQEHLASLQEQ 447
+ + E R + + Q EE E E +R + +A E L EQ
Sbjct: 2085 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144
Query: 448 VAV--------LTRQNQ----ELMEKVQILENFEKDETQMEVEALAEVIPLALYDSLRAE 495
A RQ Q E+ + + E + + Q+E E + L D +
Sbjct: 2145 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204
Query: 496 FDQ-LRRQHAEALQALRQQETRE-------VPREEGA---ACGESEVAGATATKNGPTHM 544
D+ L+R AEA +A RQ+ E V EE + A E+E T
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 545 ELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAK----VTETK 600
L A + K E A E R + E + AE + V E
Sbjct: 2265 FLQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2323
Query: 601 PTGAEV----REMETTEEEAN--METKPTGAQATDTETTGVEA-----------MGVEAT 643
AE ++ E +E+A E K AQ ET G + M EA
Sbjct: 2324 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383
Query: 644 KTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRATGME-STGVSATGVENPGVEATVP 702
+ K AEM A E E G + E +T T V+ ++
Sbjct: 2384 RLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2441
Query: 703 GISAGPILHPGAAEASEKLQVELETRIRGLE-EALRQREREAAAELEAALGKCEAAEAEA 761
A + A EK +++ E ++ L+ E ++ ++E + AL + +E ++
Sbjct: 2442 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2501
Query: 762 GRLRERVREAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRL-RELEAASACLDEARA 820
RER E E + + A +Q RE+ + + ++ +E + A ++EAR
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEV----AKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557
Query: 821 SRLLAEEEARGLRAELAQREEARLEQS-----------RELEVLREQLATARATGEQ--- 866
+ AEE R + EL Q E+ R +Q +L++L EQ A A E+
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617
Query: 867 -QRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRRLQE 924
Q A L RDA + AE A E + GL A ++ A E +RL +
Sbjct: 2618 SQVAATKTLPNGRDALDGPAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2674
Score = 72.4 bits (176), Expect = 2e-12
Identities = 77/298 (25%), Positives = 128/298 (42%), Gaps = 23/298 (7%)
Query: 838 QREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQ 897
+ EE EQ R E RE+LA A E+QR A +A+ AE EL +E
Sbjct: 1345 EEEERLAEQQRAEE--RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--- 1399
Query: 898 GLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERE 957
E+ EA +V + R +QEE +LR + + Q + A R R +E E
Sbjct: 1400 ---EVVRREEA---AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453
Query: 958 -RVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAA 1016
RV + L ER G + + L + EE + + E +++R+ + A
Sbjct: 1454 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513
Query: 1017 EAQLATAEQQLRGLRTEAERARQAQSRAQEALD----KAKEKDKKITELSKEVFNLKEAL 1072
E +LA+ ++ EAE AR+ Q RA +AL+ +A+E ++++ + E +
Sbjct: 1514 EVELASR------VKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566
Query: 1073 KEQPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDVQR 1130
E A E+++ R + QL+ + ++ VA R Q Q + + R
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1624
Score = 38.5 bits (88), Expect = 0.037
Identities = 76/332 (22%), Positives = 131/332 (39%), Gaps = 42/332 (12%)
Query: 786 QLRAALEQ-AREDLRDRD--SRLRELEAASACLDEARASRL---LAEEEARGLRAELAQR 839
QL +LEQ A+E+ R + S L+++ + RL L +E AR +A++
Sbjct: 967 QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ 1026
Query: 840 EEARLEQSRELEVLREQLATARATGEQQRTAAAELGRA---RDAAEARVAELPAACEEAR 896
++A+ E +E L + +A A E+ A R E + +L +
Sbjct: 1027 QKAQAE----VEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1082
Query: 897 QGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELER 956
L +L+ S +R A E R EE L+ + E+ AT +LRA+ E
Sbjct: 1083 IYLEKLKTISLVIR-GTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1141
Query: 957 ERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAA 1016
++ AL + R AQ G E L +RH + EV + + + A
Sbjct: 1142 QQPTFDALRDELR--------GAQEVG--ERLQQRHGERDVEVERWRERVAQLLERWQAV 1191
Query: 1017 EAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP 1076
AQ +++L L + R++ L A+ + +EQ
Sbjct: 1192 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR------------------QEQI 1233
Query: 1077 AALATPEVEALRDQVKDLQQQLQEAARDHSSV 1108
A+ + +A+R+Q++ Q L+E R V
Sbjct: 1234 QAMPLADSQAVREQLRQEQALLEEIERHGEKV 1265
Score = 37.7 bits (86), Expect = 0.063
Identities = 59/266 (22%), Positives = 101/266 (37%), Gaps = 45/266 (16%)
Query: 886 AELPAACEEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQ---EVVA 942
A+ + C+ L ++R EA V +E A E R A ++ EV
Sbjct: 976 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1035
Query: 943 TGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLE---------------- 986
GK ARL AE E+ +AL E TL++ + G+LE
Sbjct: 1036 LGKGVARLSAEAEKV----LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1091
Query: 987 -----------ELGRRHEK-------TSAEVFQVQREALFMKSERHAAEAQLATAE---Q 1025
E+ R HE+ A + +++ +K R AEAQ T +
Sbjct: 1092 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1151
Query: 1026 QLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVE 1085
+LRG + ER +Q +++ +E+ ++ E + V + + + L ++
Sbjct: 1152 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR-QLR 1210
Query: 1086 ALRDQVKDLQQQLQEAARDHSSVVAL 1111
R+ L LQ+A R + A+
Sbjct: 1211 YYRESADPLGAWLQDARRRQEQIQAM 1236
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 126 bits (316), Expect = 1e-28
Identities = 225/948 (23%), Positives = 364/948 (38%), Gaps = 165/948 (17%)
Query: 318 DDRDAYEEIVRLRQERGRLLQKIRGLEQHKER--RQQESPEASSLHILERQVQELQQLLV 375
D R Y E+ L + + + + + +ER QQ + E L +E +++ +QL
Sbjct: 1286 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE 1345
Query: 376 ERQEEKESLGREVESLQSRLSLLENERENTSYDVT----TLQDEEGELPDLPGAEVLLSR 431
+ K RE + LQ R+ RE + D ++Q+E +L AE+
Sbjct: 1346 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1405
Query: 432 QLSPSAQEHLASLQEQVAVL----------------------------TRQNQELMEKVQ 463
+ + +A+ ++E++ V+ Q ++ E+ +
Sbjct: 1406 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1465
Query: 464 ILENFEKDETQMEVEALAEVIPLALYDSLRAEFDQLRRQHAEALQALRQQETREVPREEG 523
L +DE+Q + +A E+ ++ A Q Q E L+ ++ R + + E
Sbjct: 1466 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1525
Query: 524 AACGESEVAGATATKNGPTHMELNGSVAPETKVNGAETIDEEAAG-----DETMEARTME 578
+ +VA TA ++ ++ + E ++ EE +E +
Sbjct: 1526 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1585
Query: 579 AEATGA----------------EATGAEATGAKVTETKPTGAEVREMETTEEEANMETKP 622
AEA A EA +V + K E E +EEA E +
Sbjct: 1586 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ--AEAEKQKEEAEREARR 1643
Query: 623 TGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAE------PPVTGTTNMEATG 676
G + + + + + + + AE A A + E G +
Sbjct: 1644 RG--KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1701
Query: 677 SRATGMESTGVSATGVENPGVEATVPGISAG-PILHPGAAEA-------SEKLQVELE-- 726
++ +AT + +EA + + A +L A A SEK + LE
Sbjct: 1702 EELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1760
Query: 727 -----------TRIRGL-EEALRQR---EREAA---AELEAALGKCEAAEAEAGRLRE-- 766
R+R L EEA RQR E +AA AE E L + AA EA RL+
Sbjct: 1761 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1820
Query: 767 ----RVREAEGSGASGGGGGDTTQLRAALEQA---REDLRDRDSRLR-----ELEAASAC 814
+ +EAE + Q R EQA + D+ +R ++LR ELE
Sbjct: 1821 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1880
Query: 815 LDEARASRLLAEEEARGLRAELAQREEARLEQSRELEVLREQLATARATGEQ-------Q 867
+++ R EEE L+A + + E EL +R + EQ Q
Sbjct: 1881 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1940
Query: 868 RTAAAELGRARDAAEARVAELPAACEE-ARQGLAELREASEALRQSVVPASEHRRLQEEA 926
R AAE R R AE RV + AA EE ARQ A L E E L+ V E RRL+E A
Sbjct: 1941 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKV---EEARRLRERA 1996
Query: 927 LELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHERIVGTLQAN---VAQLEG 983
+ R L Q EAA+ R + E + + + + TLQ + QL G
Sbjct: 1997 EQESARQLQLAQ-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2049
Query: 984 QLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRG----------LRTE 1033
+ E R E+ Q +REA + + AE +AE+Q + LR E
Sbjct: 2050 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2109
Query: 1034 AE-------RARQAQSRAQEALDKAKEKDKKITE--------LSKEVFNLKEALKEQPAA 1078
AE +A QA R ++A D EK KK E + +E+ L+ L+E
Sbjct: 2110 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---- 2165
Query: 1079 LATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDE 1126
+ L ++++ L+ + EAAR S V L++++ QM+E
Sbjct: 2166 -TDHQKNLLDEELQRLKAEATEAARQRSQV-----EEELFSVRVQMEE 2207
Score = 107 bits (266), Expect = 8e-23
Identities = 226/919 (24%), Positives = 366/919 (39%), Gaps = 134/919 (14%)
Query: 257 AGDKLILHL-LQEAAQRPSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPP---- 311
A + L L L +E AQ+ S A E EA + ++ A ++R+
Sbjct: 1606 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1665
Query: 312 ---ASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQ 368
A A +E++RLR E + Q+ + LE+ R Q+E+ A+ ++ Q
Sbjct: 1666 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT------QKRQ 1719
Query: 369 ELQQLLVERQEEKESLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVL 428
EL+ L + + E E L L S+ E R + L+ E G +L E
Sbjct: 1720 ELEAELAKVRAEMEVL------LASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAA 1772
Query: 429 LSRQLSPSAQEHLASLQEQVAVLTRQNQE----LMEKVQILENFEKDETQMEVEALAEVI 484
R L+ A+ +E A RQ E L EK+ + + +T+ E+ AL E
Sbjct: 1773 RLRALAEEAKRQRQLAEEDAA---RQRAEAERVLAEKLAAIGEATRLKTEAEI-ALKE-- 1826
Query: 485 PLALYDSLRAEFDQLRR-QHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTH 543
AE ++LRR EA Q R EE AA ++++
Sbjct: 1827 -------KEAENERLRRLAEDEAFQRRR--------LEEQAAQHKADI------------ 1859
Query: 544 MELNGSVAPETKVNGAETIDEEAAGDETM-EARTMEAEATGAEATGAEATGAKVTETKPT 602
+A K + +E ++ ++T+ + R +E E +A+ +A K
Sbjct: 1860 ---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1916
Query: 603 GAEVREMETT---EEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGA 659
G E T +E+A +E A + E EA E K+ AE +A A
Sbjct: 1917 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA---EERVQKSLAAEEEA----A 1969
Query: 660 GQAEPPVTGTTNMEATGSRATGMESTGVSATGVE-NPGVEATVPGISAGPILHPGAAEAS 718
Q + + ++A A + + + EA + A H A +
Sbjct: 1970 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2029
Query: 719 EKLQVELETRIRGLEEALRQREREAAAELEAALGKCEA---AEAEAGRLRERVREAEGSG 775
E+ EL+ ++ + L Q EA A AA EA AE EA + R +V EAE
Sbjct: 2030 EQ---ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2086
Query: 776 ASGGGGGDTTQLRAALEQAREDLRD--RDSRLRELEAASACLDEARASRLLAEEEARGLR 833
S + Q RA + A E LR R +A A L + +A+ AE E
Sbjct: 2087 QS---AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD--AEMEKHKKF 2141
Query: 834 AELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRAR-DAAEA-----RVAE 887
AE R++A++EQ EL LR QL T Q+ EL R + +A EA +V E
Sbjct: 2142 AEQTLRQKAQVEQ--ELTTLRLQL---EETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2196
Query: 888 LPAACEEARQGLAELREASEALRQSVV---PASEHRRLQEEALELRGRAASLEQEVVATG 944
+ + L++L+ EA ++++ + R LQEEA +++ A + VA
Sbjct: 2197 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA-A 2255
Query: 945 KEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQR 1004
+EAARLR E + AL+ EK E Q +
Sbjct: 2256 QEAARLRQLAEEDLAQQRALA---------------------------EKMLKEKMQAVQ 2288
Query: 1005 EALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDK-KITELSK 1063
EA +K+E + Q A++Q R L+ + E+ Q + + + E ++ + E+S
Sbjct: 2289 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2348
Query: 1064 EVFNLKEALKEQPAALATPEVEA--LRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQ 1121
E LK + E A A E +A R Q +++ ++L V L ++ L +
Sbjct: 2349 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--LEIQR 2406
Query: 1122 GQMDEDVQRILSQILQMQR 1140
Q D D +R+ I +++R
Sbjct: 2407 QQSDHDAERLREAIAELER 2425
Score = 75.5 bits (184), Expect = 3e-13
Identities = 212/898 (23%), Positives = 350/898 (38%), Gaps = 137/898 (15%)
Query: 312 ASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQ 371
A + R E R R+E +QK E+ R+++ + E + L+ +V+E +
Sbjct: 1933 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE--EVERLKAKVEEAR 1990
Query: 372 QLLVE-RQEEKESLGREVESLQSRLSLLENE-----RENTSYDVTTLQDEEGELPDLPGA 425
+L QE L E+ Q RL E ++ TLQ E+ L L G
Sbjct: 1991 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG- 2049
Query: 426 EVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIP 485
E +R+ + A+E + + A RQ +E Q E E+ + + + +A AE
Sbjct: 2050 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAE--- 2104
Query: 486 LALYDSLRAEFDQLRRQHAEALQA-LRQQETREVPREEGAACGESEVAGATATKNGPTHM 544
LR E +Q + A+A QA LRQ++ + E+ + A T +
Sbjct: 2105 -----KLRKEAEQEAARRAQAEQAALRQKQAADAEMEK-----HKKFAEQTLRQKAQVEQ 2154
Query: 545 ELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGA 604
EL ++ ET ++ DE E + ++AEAT A ++ E +
Sbjct: 2155 ELT-----TLRLQLEETDHQKNLLDE--ELQRLKAEATEAARQRSQV------EEELFSV 2201
Query: 605 EVREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEP 664
V+ E ++ +A +E + D + T + EA K K E V A +A
Sbjct: 2202 RVQMEELSKLKARIEAENRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAAR 2260
Query: 665 PVTGTTNMEATGSRATGMESTGVSATGV-ENPGVEATVPGISAGPILHPGAA----EASE 719
+ + RA + V E ++A + L A E E
Sbjct: 2261 -LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2319
Query: 720 KLQVELETRIRGLE---EALRQREREAAAELE------AALGKCEA-AEAEAGRLRERVR 769
++ +L +G + EA RQR+ E +AE E A + + +A AE +A R R +
Sbjct: 2320 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR---K 2376
Query: 770 EAEGSGASGGGGGDTTQLRAALEQAREDLR---DRDS-RLRE----LEAASACLD-EARA 820
+AE G TQ + L Q E R D D+ RLRE LE L EA+
Sbjct: 2377 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2436
Query: 821 SRLLAEE-----------EARGLRAELAQREEARLEQSRELE--------VLREQLATAR 861
+L +EE E + L+ +++ L++ R +E + ++++A A+
Sbjct: 2437 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2496
Query: 862 ATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRR 921
E+Q+ ++ + R L A+ EEAR+ E E ++ + + RR
Sbjct: 2497 QLREEQQRQQQQMEQERQ-------RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2549
Query: 922 LQEEALELRGRAASLEQEVVATGKEAARLRAELE-RERVCSVALSEHERIVGTLQANVAQ 980
QEE L +E RLR +L+ E AL+ E + + A
Sbjct: 2550 QQEELL----------------AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2593
Query: 981 LEGQLEEL-GRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLR---GLRTEAER 1036
L + L G E F R + S + EA + +AE+ R G T E
Sbjct: 2594 LPNGRDALDGPAAEAEPEHSFDGLRRKV---SAQRLQEAGILSAEELQRLAQGHTTVDEL 2650
Query: 1037 ARQ------AQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVEA---- 1086
AR+ Q R+ A K ++K++ + L+ L AL E +A
Sbjct: 2651 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAA----LQRQLLSPGTALILLEAQAASGF 2706
Query: 1087 LRDQVKDLQQQLQEAARDHSSVVALYRSHLLY----AIQGQMDEDVQRILSQILQMQR 1140
L D V++ + + EA ++ VV H L A+ G D + +S MQ+
Sbjct: 2707 LLDPVRNRRLTVNEAVKE--GVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQK 2762
Score = 72.8 bits (177), Expect = 2e-12
Identities = 170/719 (23%), Positives = 267/719 (37%), Gaps = 77/719 (10%)
Query: 270 AQRPSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRL 329
A R +A E EA + S ++ A ++RKA +A R
Sbjct: 1937 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 1996
Query: 330 RQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVE 389
QE R LQ L Q +++ ++ E + ++++ QELQQ L + Q + L E E
Sbjct: 1997 EQESARQLQ----LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2052
Query: 390 SLQSRLSLLENERENTSYDV--TTLQDEEGELPDLPGAEVLLSRQLSPSAQEHLASLQEQ 447
+ + E R + + Q EE E E +R + +A E L EQ
Sbjct: 2053 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2112
Query: 448 VAV--------LTRQNQ----ELMEKVQILENFEKDETQMEVEALAEVIPLALYDSLRAE 495
A RQ Q E+ + + E + + Q+E E + L D +
Sbjct: 2113 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2172
Query: 496 FDQ-LRRQHAEALQALRQQETRE-------VPREEGA---ACGESEVAGATATKNGPTHM 544
D+ L+R AEA +A RQ+ E V EE + A E+E T
Sbjct: 2173 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2232
Query: 545 ELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAK----VTETK 600
L A + K E A E R + E + AE + V E
Sbjct: 2233 FLQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2291
Query: 601 PTGAEV----REMETTEEEAN--METKPTGAQATDTETTGVEA-----------MGVEAT 643
AE ++ E +E+A E K AQ ET G + M EA
Sbjct: 2292 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2351
Query: 644 KTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRATGME-STGVSATGVENPGVEATVP 702
+ K AEM A E E G + E +T T V+ ++
Sbjct: 2352 RLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2409
Query: 703 GISAGPILHPGAAEASEKLQVELETRIRGLE-EALRQREREAAAELEAALGKCEAAEAEA 761
A + A EK +++ E ++ L+ E ++ ++E + AL + +E ++
Sbjct: 2410 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2469
Query: 762 GRLRERVREAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRL-RELEAASACLDEARA 820
RER E E + + A +Q RE+ + + ++ +E + A ++EAR
Sbjct: 2470 LLQRERFIEQEKAKLEQLFQDEV----AKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2525
Query: 821 SRLLAEEEARGLRAELAQREEARLEQS-----------RELEVLREQLATARATGEQ--- 866
+ AEE R + EL Q E+ R +Q +L++L EQ A A E+
Sbjct: 2526 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2585
Query: 867 -QRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRRLQE 924
Q A L RDA + AE A E + GL A ++ A E +RL +
Sbjct: 2586 SQVAATKTLPNGRDALDGPAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2642
Score = 72.4 bits (176), Expect = 2e-12
Identities = 77/298 (25%), Positives = 128/298 (42%), Gaps = 23/298 (7%)
Query: 838 QREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQ 897
+ EE EQ R E RE+LA A E+QR A +A+ AE EL +E
Sbjct: 1313 EEEERLAEQQRAEE--RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--- 1367
Query: 898 GLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERE 957
E+ EA +V + R +QEE +LR + + Q + A R R +E E
Sbjct: 1368 ---EVVRREEA---AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1421
Query: 958 -RVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAA 1016
RV + L ER G + + L + EE + + E +++R+ + A
Sbjct: 1422 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1481
Query: 1017 EAQLATAEQQLRGLRTEAERARQAQSRAQEALD----KAKEKDKKITELSKEVFNLKEAL 1072
E +LA+ ++ EAE AR+ Q RA +AL+ +A+E ++++ + E +
Sbjct: 1482 EVELASR------VKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVERARQVQVA 1534
Query: 1073 KEQPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDVQR 1130
E A E+++ R + QL+ + ++ VA R Q Q + + R
Sbjct: 1535 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1592
Score = 38.5 bits (88), Expect = 0.037
Identities = 76/332 (22%), Positives = 131/332 (39%), Gaps = 42/332 (12%)
Query: 786 QLRAALEQ-AREDLRDRD--SRLRELEAASACLDEARASRL---LAEEEARGLRAELAQR 839
QL +LEQ A+E+ R + S L+++ + RL L +E AR +A++
Sbjct: 935 QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ 994
Query: 840 EEARLEQSRELEVLREQLATARATGEQQRTAAAELGRA---RDAAEARVAELPAACEEAR 896
++A+ E +E L + +A A E+ A R E + +L +
Sbjct: 995 QKAQAE----VEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1050
Query: 897 QGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELER 956
L +L+ S +R A E R EE L+ + E+ AT +LRA+ E
Sbjct: 1051 IYLEKLKTISLVIR-GTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1109
Query: 957 ERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAA 1016
++ AL + R AQ G E L +RH + EV + + + A
Sbjct: 1110 QQPTFDALRDELR--------GAQEVG--ERLQQRHGERDVEVERWRERVAQLLERWQAV 1159
Query: 1017 EAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP 1076
AQ +++L L + R++ L A+ + +EQ
Sbjct: 1160 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR------------------QEQI 1201
Query: 1077 AALATPEVEALRDQVKDLQQQLQEAARDHSSV 1108
A+ + +A+R+Q++ Q L+E R V
Sbjct: 1202 QAMPLADSQAVREQLRQEQALLEEIERHGEKV 1233
Score = 37.7 bits (86), Expect = 0.063
Identities = 59/266 (22%), Positives = 101/266 (37%), Gaps = 45/266 (16%)
Query: 886 AELPAACEEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQ---EVVA 942
A+ + C+ L ++R EA V +E A E R A ++ EV
Sbjct: 944 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1003
Query: 943 TGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLE---------------- 986
GK ARL AE E+ +AL E TL++ + G+LE
Sbjct: 1004 LGKGVARLSAEAEKV----LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1059
Query: 987 -----------ELGRRHEK-------TSAEVFQVQREALFMKSERHAAEAQLATAE---Q 1025
E+ R HE+ A + +++ +K R AEAQ T +
Sbjct: 1060 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1119
Query: 1026 QLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVE 1085
+LRG + ER +Q +++ +E+ ++ E + V + + + L ++
Sbjct: 1120 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR-QLR 1178
Query: 1086 ALRDQVKDLQQQLQEAARDHSSVVAL 1111
R+ L LQ+A R + A+
Sbjct: 1179 YYRESADPLGAWLQDARRRQEQIQAM 1204
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 126 bits (316), Expect = 1e-28
Identities = 225/948 (23%), Positives = 364/948 (38%), Gaps = 165/948 (17%)
Query: 318 DDRDAYEEIVRLRQERGRLLQKIRGLEQHKER--RQQESPEASSLHILERQVQELQQLLV 375
D R Y E+ L + + + + + +ER QQ + E L +E +++ +QL
Sbjct: 1455 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE 1514
Query: 376 ERQEEKESLGREVESLQSRLSLLENERENTSYDVT----TLQDEEGELPDLPGAEVLLSR 431
+ K RE + LQ R+ RE + D ++Q+E +L AE+
Sbjct: 1515 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1574
Query: 432 QLSPSAQEHLASLQEQVAVL----------------------------TRQNQELMEKVQ 463
+ + +A+ ++E++ V+ Q ++ E+ +
Sbjct: 1575 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1634
Query: 464 ILENFEKDETQMEVEALAEVIPLALYDSLRAEFDQLRRQHAEALQALRQQETREVPREEG 523
L +DE+Q + +A E+ ++ A Q Q E L+ ++ R + + E
Sbjct: 1635 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1694
Query: 524 AACGESEVAGATATKNGPTHMELNGSVAPETKVNGAETIDEEAAG-----DETMEARTME 578
+ +VA TA ++ ++ + E ++ EE +E +
Sbjct: 1695 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1754
Query: 579 AEATGA----------------EATGAEATGAKVTETKPTGAEVREMETTEEEANMETKP 622
AEA A EA +V + K E E +EEA E +
Sbjct: 1755 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ--AEAEKQKEEAEREARR 1812
Query: 623 TGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAE------PPVTGTTNMEATG 676
G + + + + + + + AE A A + E G +
Sbjct: 1813 RG--KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1870
Query: 677 SRATGMESTGVSATGVENPGVEATVPGISAG-PILHPGAAEA-------SEKLQVELE-- 726
++ +AT + +EA + + A +L A A SEK + LE
Sbjct: 1871 EELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1929
Query: 727 -----------TRIRGL-EEALRQR---EREAA---AELEAALGKCEAAEAEAGRLRE-- 766
R+R L EEA RQR E +AA AE E L + AA EA RL+
Sbjct: 1930 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1989
Query: 767 ----RVREAEGSGASGGGGGDTTQLRAALEQA---REDLRDRDSRLR-----ELEAASAC 814
+ +EAE + Q R EQA + D+ +R ++LR ELE
Sbjct: 1990 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 2049
Query: 815 LDEARASRLLAEEEARGLRAELAQREEARLEQSRELEVLREQLATARATGEQ-------Q 867
+++ R EEE L+A + + E EL +R + EQ Q
Sbjct: 2050 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 2109
Query: 868 RTAAAELGRARDAAEARVAELPAACEE-ARQGLAELREASEALRQSVVPASEHRRLQEEA 926
R AAE R R AE RV + AA EE ARQ A L E E L+ V E RRL+E A
Sbjct: 2110 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKV---EEARRLRERA 2165
Query: 927 LELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHERIVGTLQAN---VAQLEG 983
+ R L Q EAA+ R + E + + + + TLQ + QL G
Sbjct: 2166 EQESARQLQLAQ-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2218
Query: 984 QLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRG----------LRTE 1033
+ E R E+ Q +REA + + AE +AE+Q + LR E
Sbjct: 2219 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2278
Query: 1034 AE-------RARQAQSRAQEALDKAKEKDKKITE--------LSKEVFNLKEALKEQPAA 1078
AE +A QA R ++A D EK KK E + +E+ L+ L+E
Sbjct: 2279 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---- 2334
Query: 1079 LATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDE 1126
+ L ++++ L+ + EAAR S V L++++ QM+E
Sbjct: 2335 -TDHQKNLLDEELQRLKAEATEAARQRSQV-----EEELFSVRVQMEE 2376
Score = 107 bits (266), Expect = 8e-23
Identities = 226/919 (24%), Positives = 366/919 (39%), Gaps = 134/919 (14%)
Query: 257 AGDKLILHL-LQEAAQRPSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPP---- 311
A + L L L +E AQ+ S A E EA + ++ A ++R+
Sbjct: 1775 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1834
Query: 312 ---ASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQ 368
A A +E++RLR E + Q+ + LE+ R Q+E+ A+ ++ Q
Sbjct: 1835 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT------QKRQ 1888
Query: 369 ELQQLLVERQEEKESLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVL 428
EL+ L + + E E L L S+ E R + L+ E G +L E
Sbjct: 1889 ELEAELAKVRAEMEVL------LASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAA 1941
Query: 429 LSRQLSPSAQEHLASLQEQVAVLTRQNQE----LMEKVQILENFEKDETQMEVEALAEVI 484
R L+ A+ +E A RQ E L EK+ + + +T+ E+ AL E
Sbjct: 1942 RLRALAEEAKRQRQLAEEDAA---RQRAEAERVLAEKLAAIGEATRLKTEAEI-ALKE-- 1995
Query: 485 PLALYDSLRAEFDQLRR-QHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTH 543
AE ++LRR EA Q R EE AA ++++
Sbjct: 1996 -------KEAENERLRRLAEDEAFQRRR--------LEEQAAQHKADI------------ 2028
Query: 544 MELNGSVAPETKVNGAETIDEEAAGDETM-EARTMEAEATGAEATGAEATGAKVTETKPT 602
+A K + +E ++ ++T+ + R +E E +A+ +A K
Sbjct: 2029 ---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 2085
Query: 603 GAEVREMETT---EEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGA 659
G E T +E+A +E A + E EA E K+ AE +A A
Sbjct: 2086 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA---EERVQKSLAAEEEA----A 2138
Query: 660 GQAEPPVTGTTNMEATGSRATGMESTGVSATGVE-NPGVEATVPGISAGPILHPGAAEAS 718
Q + + ++A A + + + EA + A H A +
Sbjct: 2139 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2198
Query: 719 EKLQVELETRIRGLEEALRQREREAAAELEAALGKCEA---AEAEAGRLRERVREAEGSG 775
E+ EL+ ++ + L Q EA A AA EA AE EA + R +V EAE
Sbjct: 2199 EQ---ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2255
Query: 776 ASGGGGGDTTQLRAALEQAREDLRD--RDSRLRELEAASACLDEARASRLLAEEEARGLR 833
S + Q RA + A E LR R +A A L + +A+ AE E
Sbjct: 2256 QS---AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD--AEMEKHKKF 2310
Query: 834 AELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRAR-DAAEA-----RVAE 887
AE R++A++EQ EL LR QL T Q+ EL R + +A EA +V E
Sbjct: 2311 AEQTLRQKAQVEQ--ELTTLRLQL---EETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2365
Query: 888 LPAACEEARQGLAELREASEALRQSVV---PASEHRRLQEEALELRGRAASLEQEVVATG 944
+ + L++L+ EA ++++ + R LQEEA +++ A + VA
Sbjct: 2366 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA-A 2424
Query: 945 KEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQR 1004
+EAARLR E + AL+ EK E Q +
Sbjct: 2425 QEAARLRQLAEEDLAQQRALA---------------------------EKMLKEKMQAVQ 2457
Query: 1005 EALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDK-KITELSK 1063
EA +K+E + Q A++Q R L+ + E+ Q + + + E ++ + E+S
Sbjct: 2458 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2517
Query: 1064 EVFNLKEALKEQPAALATPEVEA--LRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQ 1121
E LK + E A A E +A R Q +++ ++L V L ++ L +
Sbjct: 2518 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--LEIQR 2575
Query: 1122 GQMDEDVQRILSQILQMQR 1140
Q D D +R+ I +++R
Sbjct: 2576 QQSDHDAERLREAIAELER 2594
Score = 75.5 bits (184), Expect = 3e-13
Identities = 212/898 (23%), Positives = 350/898 (38%), Gaps = 137/898 (15%)
Query: 312 ASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQ 371
A + R E R R+E +QK E+ R+++ + E + L+ +V+E +
Sbjct: 2102 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE--EVERLKAKVEEAR 2159
Query: 372 QLLVE-RQEEKESLGREVESLQSRLSLLENE-----RENTSYDVTTLQDEEGELPDLPGA 425
+L QE L E+ Q RL E ++ TLQ E+ L L G
Sbjct: 2160 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG- 2218
Query: 426 EVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIP 485
E +R+ + A+E + + A RQ +E Q E E+ + + + +A AE
Sbjct: 2219 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAE--- 2273
Query: 486 LALYDSLRAEFDQLRRQHAEALQA-LRQQETREVPREEGAACGESEVAGATATKNGPTHM 544
LR E +Q + A+A QA LRQ++ + E+ + A T +
Sbjct: 2274 -----KLRKEAEQEAARRAQAEQAALRQKQAADAEMEK-----HKKFAEQTLRQKAQVEQ 2323
Query: 545 ELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGA 604
EL ++ ET ++ DE E + ++AEAT A ++ E +
Sbjct: 2324 ELT-----TLRLQLEETDHQKNLLDE--ELQRLKAEATEAARQRSQV------EEELFSV 2370
Query: 605 EVREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEP 664
V+ E ++ +A +E + D + T + EA K K E V A +A
Sbjct: 2371 RVQMEELSKLKARIEAENRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAAR 2429
Query: 665 PVTGTTNMEATGSRATGMESTGVSATGV-ENPGVEATVPGISAGPILHPGAA----EASE 719
+ + RA + V E ++A + L A E E
Sbjct: 2430 -LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2488
Query: 720 KLQVELETRIRGLE---EALRQREREAAAELE------AALGKCEA-AEAEAGRLRERVR 769
++ +L +G + EA RQR+ E +AE E A + + +A AE +A R R +
Sbjct: 2489 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR---K 2545
Query: 770 EAEGSGASGGGGGDTTQLRAALEQAREDLR---DRDS-RLRE----LEAASACLD-EARA 820
+AE G TQ + L Q E R D D+ RLRE LE L EA+
Sbjct: 2546 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2605
Query: 821 SRLLAEE-----------EARGLRAELAQREEARLEQSRELE--------VLREQLATAR 861
+L +EE E + L+ +++ L++ R +E + ++++A A+
Sbjct: 2606 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2665
Query: 862 ATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRR 921
E+Q+ ++ + R L A+ EEAR+ E E ++ + + RR
Sbjct: 2666 QLREEQQRQQQQMEQERQ-------RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2718
Query: 922 LQEEALELRGRAASLEQEVVATGKEAARLRAELE-RERVCSVALSEHERIVGTLQANVAQ 980
QEE L +E RLR +L+ E AL+ E + + A
Sbjct: 2719 QQEELL----------------AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2762
Query: 981 LEGQLEEL-GRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLR---GLRTEAER 1036
L + L G E F R + S + EA + +AE+ R G T E
Sbjct: 2763 LPNGRDALDGPAAEAEPEHSFDGLRRKV---SAQRLQEAGILSAEELQRLAQGHTTVDEL 2819
Query: 1037 ARQ------AQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVEA---- 1086
AR+ Q R+ A K ++K++ + L+ L AL E +A
Sbjct: 2820 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAA----LQRQLLSPGTALILLEAQAASGF 2875
Query: 1087 LRDQVKDLQQQLQEAARDHSSVVALYRSHLLY----AIQGQMDEDVQRILSQILQMQR 1140
L D V++ + + EA ++ VV H L A+ G D + +S MQ+
Sbjct: 2876 LLDPVRNRRLTVNEAVKE--GVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQK 2931
Score = 72.8 bits (177), Expect = 2e-12
Identities = 170/719 (23%), Positives = 267/719 (37%), Gaps = 77/719 (10%)
Query: 270 AQRPSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRL 329
A R +A E EA + S ++ A ++RKA +A R
Sbjct: 2106 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2165
Query: 330 RQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVE 389
QE R LQ L Q +++ ++ E + ++++ QELQQ L + Q + L E E
Sbjct: 2166 EQESARQLQ----LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2221
Query: 390 SLQSRLSLLENERENTSYDV--TTLQDEEGELPDLPGAEVLLSRQLSPSAQEHLASLQEQ 447
+ + E R + + Q EE E E +R + +A E L EQ
Sbjct: 2222 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2281
Query: 448 VAV--------LTRQNQ----ELMEKVQILENFEKDETQMEVEALAEVIPLALYDSLRAE 495
A RQ Q E+ + + E + + Q+E E + L D +
Sbjct: 2282 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2341
Query: 496 FDQ-LRRQHAEALQALRQQETRE-------VPREEGA---ACGESEVAGATATKNGPTHM 544
D+ L+R AEA +A RQ+ E V EE + A E+E T
Sbjct: 2342 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401
Query: 545 ELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAK----VTETK 600
L A + K E A E R + E + AE + V E
Sbjct: 2402 FLQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2460
Query: 601 PTGAEV----REMETTEEEAN--METKPTGAQATDTETTGVEA-----------MGVEAT 643
AE ++ E +E+A E K AQ ET G + M EA
Sbjct: 2461 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2520
Query: 644 KTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRATGME-STGVSATGVENPGVEATVP 702
+ K AEM A E E G + E +T T V+ ++
Sbjct: 2521 RLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2578
Query: 703 GISAGPILHPGAAEASEKLQVELETRIRGLE-EALRQREREAAAELEAALGKCEAAEAEA 761
A + A EK +++ E ++ L+ E ++ ++E + AL + +E ++
Sbjct: 2579 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2638
Query: 762 GRLRERVREAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRL-RELEAASACLDEARA 820
RER E E + + A +Q RE+ + + ++ +E + A ++EAR
Sbjct: 2639 LLQRERFIEQEKAKLEQLFQDEV----AKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2694
Query: 821 SRLLAEEEARGLRAELAQREEARLEQS-----------RELEVLREQLATARATGEQ--- 866
+ AEE R + EL Q E+ R +Q +L++L EQ A A E+
Sbjct: 2695 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2754
Query: 867 -QRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRRLQE 924
Q A L RDA + AE A E + GL A ++ A E +RL +
Sbjct: 2755 SQVAATKTLPNGRDALDGPAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2811
Score = 72.4 bits (176), Expect = 2e-12
Identities = 77/298 (25%), Positives = 128/298 (42%), Gaps = 23/298 (7%)
Query: 838 QREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQ 897
+ EE EQ R E RE+LA A E+QR A +A+ AE EL +E
Sbjct: 1482 EEEERLAEQQRAEE--RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--- 1536
Query: 898 GLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERE 957
E+ EA +V + R +QEE +LR + + Q + A R R +E E
Sbjct: 1537 ---EVVRREEA---AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1590
Query: 958 -RVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAA 1016
RV + L ER G + + L + EE + + E +++R+ + A
Sbjct: 1591 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1650
Query: 1017 EAQLATAEQQLRGLRTEAERARQAQSRAQEALD----KAKEKDKKITELSKEVFNLKEAL 1072
E +LA+ ++ EAE AR+ Q RA +AL+ +A+E ++++ + E +
Sbjct: 1651 EVELASR------VKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVERARQVQVA 1703
Query: 1073 KEQPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDVQR 1130
E A E+++ R + QL+ + ++ VA R Q Q + + R
Sbjct: 1704 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1761
Score = 38.5 bits (88), Expect = 0.037
Identities = 76/332 (22%), Positives = 131/332 (39%), Gaps = 42/332 (12%)
Query: 786 QLRAALEQ-AREDLRDRD--SRLRELEAASACLDEARASRL---LAEEEARGLRAELAQR 839
QL +LEQ A+E+ R + S L+++ + RL L +E AR +A++
Sbjct: 1104 QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ 1163
Query: 840 EEARLEQSRELEVLREQLATARATGEQQRTAAAELGRA---RDAAEARVAELPAACEEAR 896
++A+ E +E L + +A A E+ A R E + +L +
Sbjct: 1164 QKAQAE----VEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1219
Query: 897 QGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELER 956
L +L+ S +R A E R EE L+ + E+ AT +LRA+ E
Sbjct: 1220 IYLEKLKTISLVIR-GTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1278
Query: 957 ERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAA 1016
++ AL + R AQ G E L +RH + EV + + + A
Sbjct: 1279 QQPTFDALRDELR--------GAQEVG--ERLQQRHGERDVEVERWRERVAQLLERWQAV 1328
Query: 1017 EAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP 1076
AQ +++L L + R++ L A+ + +EQ
Sbjct: 1329 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR------------------QEQI 1370
Query: 1077 AALATPEVEALRDQVKDLQQQLQEAARDHSSV 1108
A+ + +A+R+Q++ Q L+E R V
Sbjct: 1371 QAMPLADSQAVREQLRQEQALLEEIERHGEKV 1402
Score = 37.7 bits (86), Expect = 0.063
Identities = 59/266 (22%), Positives = 101/266 (37%), Gaps = 45/266 (16%)
Query: 886 AELPAACEEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQ---EVVA 942
A+ + C+ L ++R EA V +E A E R A ++ EV
Sbjct: 1113 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1172
Query: 943 TGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLE---------------- 986
GK ARL AE E+ +AL E TL++ + G+LE
Sbjct: 1173 LGKGVARLSAEAEKV----LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1228
Query: 987 -----------ELGRRHEK-------TSAEVFQVQREALFMKSERHAAEAQLATAE---Q 1025
E+ R HE+ A + +++ +K R AEAQ T +
Sbjct: 1229 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1288
Query: 1026 QLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVE 1085
+LRG + ER +Q +++ +E+ ++ E + V + + + L ++
Sbjct: 1289 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR-QLR 1347
Query: 1086 ALRDQVKDLQQQLQEAARDHSSVVAL 1111
R+ L LQ+A R + A+
Sbjct: 1348 YYRESADPLGAWLQDARRRQEQIQAM 1373
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 126 bits (316), Expect = 1e-28
Identities = 225/948 (23%), Positives = 364/948 (38%), Gaps = 165/948 (17%)
Query: 318 DDRDAYEEIVRLRQERGRLLQKIRGLEQHKER--RQQESPEASSLHILERQVQELQQLLV 375
D R Y E+ L + + + + + +ER QQ + E L +E +++ +QL
Sbjct: 1296 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE 1355
Query: 376 ERQEEKESLGREVESLQSRLSLLENERENTSYDVT----TLQDEEGELPDLPGAEVLLSR 431
+ K RE + LQ R+ RE + D ++Q+E +L AE+
Sbjct: 1356 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1415
Query: 432 QLSPSAQEHLASLQEQVAVL----------------------------TRQNQELMEKVQ 463
+ + +A+ ++E++ V+ Q ++ E+ +
Sbjct: 1416 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1475
Query: 464 ILENFEKDETQMEVEALAEVIPLALYDSLRAEFDQLRRQHAEALQALRQQETREVPREEG 523
L +DE+Q + +A E+ ++ A Q Q E L+ ++ R + + E
Sbjct: 1476 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1535
Query: 524 AACGESEVAGATATKNGPTHMELNGSVAPETKVNGAETIDEEAAG-----DETMEARTME 578
+ +VA TA ++ ++ + E ++ EE +E +
Sbjct: 1536 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1595
Query: 579 AEATGA----------------EATGAEATGAKVTETKPTGAEVREMETTEEEANMETKP 622
AEA A EA +V + K E E +EEA E +
Sbjct: 1596 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ--AEAEKQKEEAEREARR 1653
Query: 623 TGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAE------PPVTGTTNMEATG 676
G + + + + + + + AE A A + E G +
Sbjct: 1654 RG--KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1711
Query: 677 SRATGMESTGVSATGVENPGVEATVPGISAG-PILHPGAAEA-------SEKLQVELE-- 726
++ +AT + +EA + + A +L A A SEK + LE
Sbjct: 1712 EELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1770
Query: 727 -----------TRIRGL-EEALRQR---EREAA---AELEAALGKCEAAEAEAGRLRE-- 766
R+R L EEA RQR E +AA AE E L + AA EA RL+
Sbjct: 1771 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1830
Query: 767 ----RVREAEGSGASGGGGGDTTQLRAALEQA---REDLRDRDSRLR-----ELEAASAC 814
+ +EAE + Q R EQA + D+ +R ++LR ELE
Sbjct: 1831 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1890
Query: 815 LDEARASRLLAEEEARGLRAELAQREEARLEQSRELEVLREQLATARATGEQ-------Q 867
+++ R EEE L+A + + E EL +R + EQ Q
Sbjct: 1891 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1950
Query: 868 RTAAAELGRARDAAEARVAELPAACEE-ARQGLAELREASEALRQSVVPASEHRRLQEEA 926
R AAE R R AE RV + AA EE ARQ A L E E L+ V E RRL+E A
Sbjct: 1951 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKV---EEARRLRERA 2006
Query: 927 LELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHERIVGTLQAN---VAQLEG 983
+ R L Q EAA+ R + E + + + + TLQ + QL G
Sbjct: 2007 EQESARQLQLAQ-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2059
Query: 984 QLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRG----------LRTE 1033
+ E R E+ Q +REA + + AE +AE+Q + LR E
Sbjct: 2060 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2119
Query: 1034 AE-------RARQAQSRAQEALDKAKEKDKKITE--------LSKEVFNLKEALKEQPAA 1078
AE +A QA R ++A D EK KK E + +E+ L+ L+E
Sbjct: 2120 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---- 2175
Query: 1079 LATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDE 1126
+ L ++++ L+ + EAAR S V L++++ QM+E
Sbjct: 2176 -TDHQKNLLDEELQRLKAEATEAARQRSQV-----EEELFSVRVQMEE 2217
Score = 107 bits (266), Expect = 8e-23
Identities = 226/919 (24%), Positives = 366/919 (39%), Gaps = 134/919 (14%)
Query: 257 AGDKLILHL-LQEAAQRPSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPP---- 311
A + L L L +E AQ+ S A E EA + ++ A ++R+
Sbjct: 1616 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1675
Query: 312 ---ASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQ 368
A A +E++RLR E + Q+ + LE+ R Q+E+ A+ ++ Q
Sbjct: 1676 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT------QKRQ 1729
Query: 369 ELQQLLVERQEEKESLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVL 428
EL+ L + + E E L L S+ E R + L+ E G +L E
Sbjct: 1730 ELEAELAKVRAEMEVL------LASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAA 1782
Query: 429 LSRQLSPSAQEHLASLQEQVAVLTRQNQE----LMEKVQILENFEKDETQMEVEALAEVI 484
R L+ A+ +E A RQ E L EK+ + + +T+ E+ AL E
Sbjct: 1783 RLRALAEEAKRQRQLAEEDAA---RQRAEAERVLAEKLAAIGEATRLKTEAEI-ALKE-- 1836
Query: 485 PLALYDSLRAEFDQLRR-QHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTH 543
AE ++LRR EA Q R EE AA ++++
Sbjct: 1837 -------KEAENERLRRLAEDEAFQRRR--------LEEQAAQHKADI------------ 1869
Query: 544 MELNGSVAPETKVNGAETIDEEAAGDETM-EARTMEAEATGAEATGAEATGAKVTETKPT 602
+A K + +E ++ ++T+ + R +E E +A+ +A K
Sbjct: 1870 ---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1926
Query: 603 GAEVREMETT---EEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGA 659
G E T +E+A +E A + E EA E K+ AE +A A
Sbjct: 1927 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA---EERVQKSLAAEEEA----A 1979
Query: 660 GQAEPPVTGTTNMEATGSRATGMESTGVSATGVE-NPGVEATVPGISAGPILHPGAAEAS 718
Q + + ++A A + + + EA + A H A +
Sbjct: 1980 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2039
Query: 719 EKLQVELETRIRGLEEALRQREREAAAELEAALGKCEA---AEAEAGRLRERVREAEGSG 775
E+ EL+ ++ + L Q EA A AA EA AE EA + R +V EAE
Sbjct: 2040 EQ---ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2096
Query: 776 ASGGGGGDTTQLRAALEQAREDLRD--RDSRLRELEAASACLDEARASRLLAEEEARGLR 833
S + Q RA + A E LR R +A A L + +A+ AE E
Sbjct: 2097 QS---AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD--AEMEKHKKF 2151
Query: 834 AELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRAR-DAAEA-----RVAE 887
AE R++A++EQ EL LR QL T Q+ EL R + +A EA +V E
Sbjct: 2152 AEQTLRQKAQVEQ--ELTTLRLQL---EETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2206
Query: 888 LPAACEEARQGLAELREASEALRQSVV---PASEHRRLQEEALELRGRAASLEQEVVATG 944
+ + L++L+ EA ++++ + R LQEEA +++ A + VA
Sbjct: 2207 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA-A 2265
Query: 945 KEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQR 1004
+EAARLR E + AL+ EK E Q +
Sbjct: 2266 QEAARLRQLAEEDLAQQRALA---------------------------EKMLKEKMQAVQ 2298
Query: 1005 EALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDK-KITELSK 1063
EA +K+E + Q A++Q R L+ + E+ Q + + + E ++ + E+S
Sbjct: 2299 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2358
Query: 1064 EVFNLKEALKEQPAALATPEVEA--LRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQ 1121
E LK + E A A E +A R Q +++ ++L V L ++ L +
Sbjct: 2359 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--LEIQR 2416
Query: 1122 GQMDEDVQRILSQILQMQR 1140
Q D D +R+ I +++R
Sbjct: 2417 QQSDHDAERLREAIAELER 2435
Score = 75.5 bits (184), Expect = 3e-13
Identities = 212/898 (23%), Positives = 350/898 (38%), Gaps = 137/898 (15%)
Query: 312 ASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQ 371
A + R E R R+E +QK E+ R+++ + E + L+ +V+E +
Sbjct: 1943 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE--EVERLKAKVEEAR 2000
Query: 372 QLLVE-RQEEKESLGREVESLQSRLSLLENE-----RENTSYDVTTLQDEEGELPDLPGA 425
+L QE L E+ Q RL E ++ TLQ E+ L L G
Sbjct: 2001 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG- 2059
Query: 426 EVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIP 485
E +R+ + A+E + + A RQ +E Q E E+ + + + +A AE
Sbjct: 2060 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAE--- 2114
Query: 486 LALYDSLRAEFDQLRRQHAEALQA-LRQQETREVPREEGAACGESEVAGATATKNGPTHM 544
LR E +Q + A+A QA LRQ++ + E+ + A T +
Sbjct: 2115 -----KLRKEAEQEAARRAQAEQAALRQKQAADAEMEK-----HKKFAEQTLRQKAQVEQ 2164
Query: 545 ELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGA 604
EL ++ ET ++ DE E + ++AEAT A ++ E +
Sbjct: 2165 ELT-----TLRLQLEETDHQKNLLDE--ELQRLKAEATEAARQRSQV------EEELFSV 2211
Query: 605 EVREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEP 664
V+ E ++ +A +E + D + T + EA K K E V A +A
Sbjct: 2212 RVQMEELSKLKARIEAENRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAAR 2270
Query: 665 PVTGTTNMEATGSRATGMESTGVSATGV-ENPGVEATVPGISAGPILHPGAA----EASE 719
+ + RA + V E ++A + L A E E
Sbjct: 2271 -LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2329
Query: 720 KLQVELETRIRGLE---EALRQREREAAAELE------AALGKCEA-AEAEAGRLRERVR 769
++ +L +G + EA RQR+ E +AE E A + + +A AE +A R R +
Sbjct: 2330 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR---K 2386
Query: 770 EAEGSGASGGGGGDTTQLRAALEQAREDLR---DRDS-RLRE----LEAASACLD-EARA 820
+AE G TQ + L Q E R D D+ RLRE LE L EA+
Sbjct: 2387 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2446
Query: 821 SRLLAEE-----------EARGLRAELAQREEARLEQSRELE--------VLREQLATAR 861
+L +EE E + L+ +++ L++ R +E + ++++A A+
Sbjct: 2447 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2506
Query: 862 ATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRR 921
E+Q+ ++ + R L A+ EEAR+ E E ++ + + RR
Sbjct: 2507 QLREEQQRQQQQMEQERQ-------RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2559
Query: 922 LQEEALELRGRAASLEQEVVATGKEAARLRAELE-RERVCSVALSEHERIVGTLQANVAQ 980
QEE L +E RLR +L+ E AL+ E + + A
Sbjct: 2560 QQEELL----------------AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2603
Query: 981 LEGQLEEL-GRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLR---GLRTEAER 1036
L + L G E F R + S + EA + +AE+ R G T E
Sbjct: 2604 LPNGRDALDGPAAEAEPEHSFDGLRRKV---SAQRLQEAGILSAEELQRLAQGHTTVDEL 2660
Query: 1037 ARQ------AQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVEA---- 1086
AR+ Q R+ A K ++K++ + L+ L AL E +A
Sbjct: 2661 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAA----LQRQLLSPGTALILLEAQAASGF 2716
Query: 1087 LRDQVKDLQQQLQEAARDHSSVVALYRSHLLY----AIQGQMDEDVQRILSQILQMQR 1140
L D V++ + + EA ++ VV H L A+ G D + +S MQ+
Sbjct: 2717 LLDPVRNRRLTVNEAVKE--GVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQK 2772
Score = 72.8 bits (177), Expect = 2e-12
Identities = 170/719 (23%), Positives = 267/719 (37%), Gaps = 77/719 (10%)
Query: 270 AQRPSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRL 329
A R +A E EA + S ++ A ++RKA +A R
Sbjct: 1947 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2006
Query: 330 RQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVE 389
QE R LQ L Q +++ ++ E + ++++ QELQQ L + Q + L E E
Sbjct: 2007 EQESARQLQ----LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2062
Query: 390 SLQSRLSLLENERENTSYDV--TTLQDEEGELPDLPGAEVLLSRQLSPSAQEHLASLQEQ 447
+ + E R + + Q EE E E +R + +A E L EQ
Sbjct: 2063 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2122
Query: 448 VAV--------LTRQNQ----ELMEKVQILENFEKDETQMEVEALAEVIPLALYDSLRAE 495
A RQ Q E+ + + E + + Q+E E + L D +
Sbjct: 2123 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2182
Query: 496 FDQ-LRRQHAEALQALRQQETRE-------VPREEGA---ACGESEVAGATATKNGPTHM 544
D+ L+R AEA +A RQ+ E V EE + A E+E T
Sbjct: 2183 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242
Query: 545 ELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAK----VTETK 600
L A + K E A E R + E + AE + V E
Sbjct: 2243 FLQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2301
Query: 601 PTGAEV----REMETTEEEAN--METKPTGAQATDTETTGVEA-----------MGVEAT 643
AE ++ E +E+A E K AQ ET G + M EA
Sbjct: 2302 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2361
Query: 644 KTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRATGME-STGVSATGVENPGVEATVP 702
+ K AEM A E E G + E +T T V+ ++
Sbjct: 2362 RLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2419
Query: 703 GISAGPILHPGAAEASEKLQVELETRIRGLE-EALRQREREAAAELEAALGKCEAAEAEA 761
A + A EK +++ E ++ L+ E ++ ++E + AL + +E ++
Sbjct: 2420 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2479
Query: 762 GRLRERVREAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRL-RELEAASACLDEARA 820
RER E E + + A +Q RE+ + + ++ +E + A ++EAR
Sbjct: 2480 LLQRERFIEQEKAKLEQLFQDEV----AKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2535
Query: 821 SRLLAEEEARGLRAELAQREEARLEQS-----------RELEVLREQLATARATGEQ--- 866
+ AEE R + EL Q E+ R +Q +L++L EQ A A E+
Sbjct: 2536 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2595
Query: 867 -QRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRRLQE 924
Q A L RDA + AE A E + GL A ++ A E +RL +
Sbjct: 2596 SQVAATKTLPNGRDALDGPAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2652
Score = 72.4 bits (176), Expect = 2e-12
Identities = 77/298 (25%), Positives = 128/298 (42%), Gaps = 23/298 (7%)
Query: 838 QREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQ 897
+ EE EQ R E RE+LA A E+QR A +A+ AE EL +E
Sbjct: 1323 EEEERLAEQQRAEE--RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--- 1377
Query: 898 GLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERE 957
E+ EA +V + R +QEE +LR + + Q + A R R +E E
Sbjct: 1378 ---EVVRREEA---AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1431
Query: 958 -RVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAA 1016
RV + L ER G + + L + EE + + E +++R+ + A
Sbjct: 1432 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1491
Query: 1017 EAQLATAEQQLRGLRTEAERARQAQSRAQEALD----KAKEKDKKITELSKEVFNLKEAL 1072
E +LA+ ++ EAE AR+ Q RA +AL+ +A+E ++++ + E +
Sbjct: 1492 EVELASR------VKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVERARQVQVA 1544
Query: 1073 KEQPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDVQR 1130
E A E+++ R + QL+ + ++ VA R Q Q + + R
Sbjct: 1545 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1602
Score = 38.5 bits (88), Expect = 0.037
Identities = 76/332 (22%), Positives = 131/332 (39%), Gaps = 42/332 (12%)
Query: 786 QLRAALEQ-AREDLRDRD--SRLRELEAASACLDEARASRL---LAEEEARGLRAELAQR 839
QL +LEQ A+E+ R + S L+++ + RL L +E AR +A++
Sbjct: 945 QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ 1004
Query: 840 EEARLEQSRELEVLREQLATARATGEQQRTAAAELGRA---RDAAEARVAELPAACEEAR 896
++A+ E +E L + +A A E+ A R E + +L +
Sbjct: 1005 QKAQAE----VEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1060
Query: 897 QGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELER 956
L +L+ S +R A E R EE L+ + E+ AT +LRA+ E
Sbjct: 1061 IYLEKLKTISLVIR-GTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1119
Query: 957 ERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAA 1016
++ AL + R AQ G E L +RH + EV + + + A
Sbjct: 1120 QQPTFDALRDELR--------GAQEVG--ERLQQRHGERDVEVERWRERVAQLLERWQAV 1169
Query: 1017 EAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP 1076
AQ +++L L + R++ L A+ + +EQ
Sbjct: 1170 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR------------------QEQI 1211
Query: 1077 AALATPEVEALRDQVKDLQQQLQEAARDHSSV 1108
A+ + +A+R+Q++ Q L+E R V
Sbjct: 1212 QAMPLADSQAVREQLRQEQALLEEIERHGEKV 1243
Score = 37.7 bits (86), Expect = 0.063
Identities = 59/266 (22%), Positives = 101/266 (37%), Gaps = 45/266 (16%)
Query: 886 AELPAACEEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQ---EVVA 942
A+ + C+ L ++R EA V +E A E R A ++ EV
Sbjct: 954 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1013
Query: 943 TGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLE---------------- 986
GK ARL AE E+ +AL E TL++ + G+LE
Sbjct: 1014 LGKGVARLSAEAEKV----LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1069
Query: 987 -----------ELGRRHEK-------TSAEVFQVQREALFMKSERHAAEAQLATAE---Q 1025
E+ R HE+ A + +++ +K R AEAQ T +
Sbjct: 1070 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1129
Query: 1026 QLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVE 1085
+LRG + ER +Q +++ +E+ ++ E + V + + + L ++
Sbjct: 1130 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR-QLR 1188
Query: 1086 ALRDQVKDLQQQLQEAARDHSSVVAL 1111
R+ L LQ+A R + A+
Sbjct: 1189 YYRESADPLGAWLQDARRRQEQIQAM 1214
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 126 bits (316), Expect = 1e-28
Identities = 225/948 (23%), Positives = 364/948 (38%), Gaps = 165/948 (17%)
Query: 318 DDRDAYEEIVRLRQERGRLLQKIRGLEQHKER--RQQESPEASSLHILERQVQELQQLLV 375
D R Y E+ L + + + + + +ER QQ + E L +E +++ +QL
Sbjct: 1304 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE 1363
Query: 376 ERQEEKESLGREVESLQSRLSLLENERENTSYDVT----TLQDEEGELPDLPGAEVLLSR 431
+ K RE + LQ R+ RE + D ++Q+E +L AE+
Sbjct: 1364 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1423
Query: 432 QLSPSAQEHLASLQEQVAVL----------------------------TRQNQELMEKVQ 463
+ + +A+ ++E++ V+ Q ++ E+ +
Sbjct: 1424 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1483
Query: 464 ILENFEKDETQMEVEALAEVIPLALYDSLRAEFDQLRRQHAEALQALRQQETREVPREEG 523
L +DE+Q + +A E+ ++ A Q Q E L+ ++ R + + E
Sbjct: 1484 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1543
Query: 524 AACGESEVAGATATKNGPTHMELNGSVAPETKVNGAETIDEEAAG-----DETMEARTME 578
+ +VA TA ++ ++ + E ++ EE +E +
Sbjct: 1544 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1603
Query: 579 AEATGA----------------EATGAEATGAKVTETKPTGAEVREMETTEEEANMETKP 622
AEA A EA +V + K E E +EEA E +
Sbjct: 1604 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ--AEAEKQKEEAEREARR 1661
Query: 623 TGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAE------PPVTGTTNMEATG 676
G + + + + + + + AE A A + E G +
Sbjct: 1662 RG--KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1719
Query: 677 SRATGMESTGVSATGVENPGVEATVPGISAG-PILHPGAAEA-------SEKLQVELE-- 726
++ +AT + +EA + + A +L A A SEK + LE
Sbjct: 1720 EELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1778
Query: 727 -----------TRIRGL-EEALRQR---EREAA---AELEAALGKCEAAEAEAGRLRE-- 766
R+R L EEA RQR E +AA AE E L + AA EA RL+
Sbjct: 1779 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1838
Query: 767 ----RVREAEGSGASGGGGGDTTQLRAALEQA---REDLRDRDSRLR-----ELEAASAC 814
+ +EAE + Q R EQA + D+ +R ++LR ELE
Sbjct: 1839 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1898
Query: 815 LDEARASRLLAEEEARGLRAELAQREEARLEQSRELEVLREQLATARATGEQ-------Q 867
+++ R EEE L+A + + E EL +R + EQ Q
Sbjct: 1899 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1958
Query: 868 RTAAAELGRARDAAEARVAELPAACEE-ARQGLAELREASEALRQSVVPASEHRRLQEEA 926
R AAE R R AE RV + AA EE ARQ A L E E L+ V E RRL+E A
Sbjct: 1959 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKV---EEARRLRERA 2014
Query: 927 LELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHERIVGTLQAN---VAQLEG 983
+ R L Q EAA+ R + E + + + + TLQ + QL G
Sbjct: 2015 EQESARQLQLAQ-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2067
Query: 984 QLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRG----------LRTE 1033
+ E R E+ Q +REA + + AE +AE+Q + LR E
Sbjct: 2068 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2127
Query: 1034 AE-------RARQAQSRAQEALDKAKEKDKKITE--------LSKEVFNLKEALKEQPAA 1078
AE +A QA R ++A D EK KK E + +E+ L+ L+E
Sbjct: 2128 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---- 2183
Query: 1079 LATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDE 1126
+ L ++++ L+ + EAAR S V L++++ QM+E
Sbjct: 2184 -TDHQKNLLDEELQRLKAEATEAARQRSQV-----EEELFSVRVQMEE 2225
Score = 107 bits (266), Expect = 8e-23
Identities = 226/919 (24%), Positives = 366/919 (39%), Gaps = 134/919 (14%)
Query: 257 AGDKLILHL-LQEAAQRPSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPP---- 311
A + L L L +E AQ+ S A E EA + ++ A ++R+
Sbjct: 1624 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1683
Query: 312 ---ASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQ 368
A A +E++RLR E + Q+ + LE+ R Q+E+ A+ ++ Q
Sbjct: 1684 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT------QKRQ 1737
Query: 369 ELQQLLVERQEEKESLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVL 428
EL+ L + + E E L L S+ E R + L+ E G +L E
Sbjct: 1738 ELEAELAKVRAEMEVL------LASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAA 1790
Query: 429 LSRQLSPSAQEHLASLQEQVAVLTRQNQE----LMEKVQILENFEKDETQMEVEALAEVI 484
R L+ A+ +E A RQ E L EK+ + + +T+ E+ AL E
Sbjct: 1791 RLRALAEEAKRQRQLAEEDAA---RQRAEAERVLAEKLAAIGEATRLKTEAEI-ALKE-- 1844
Query: 485 PLALYDSLRAEFDQLRR-QHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTH 543
AE ++LRR EA Q R EE AA ++++
Sbjct: 1845 -------KEAENERLRRLAEDEAFQRRR--------LEEQAAQHKADI------------ 1877
Query: 544 MELNGSVAPETKVNGAETIDEEAAGDETM-EARTMEAEATGAEATGAEATGAKVTETKPT 602
+A K + +E ++ ++T+ + R +E E +A+ +A K
Sbjct: 1878 ---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1934
Query: 603 GAEVREMETT---EEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGA 659
G E T +E+A +E A + E EA E K+ AE +A A
Sbjct: 1935 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA---EERVQKSLAAEEEA----A 1987
Query: 660 GQAEPPVTGTTNMEATGSRATGMESTGVSATGVE-NPGVEATVPGISAGPILHPGAAEAS 718
Q + + ++A A + + + EA + A H A +
Sbjct: 1988 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2047
Query: 719 EKLQVELETRIRGLEEALRQREREAAAELEAALGKCEA---AEAEAGRLRERVREAEGSG 775
E+ EL+ ++ + L Q EA A AA EA AE EA + R +V EAE
Sbjct: 2048 EQ---ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2104
Query: 776 ASGGGGGDTTQLRAALEQAREDLRD--RDSRLRELEAASACLDEARASRLLAEEEARGLR 833
S + Q RA + A E LR R +A A L + +A+ AE E
Sbjct: 2105 QS---AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD--AEMEKHKKF 2159
Query: 834 AELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRAR-DAAEA-----RVAE 887
AE R++A++EQ EL LR QL T Q+ EL R + +A EA +V E
Sbjct: 2160 AEQTLRQKAQVEQ--ELTTLRLQL---EETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2214
Query: 888 LPAACEEARQGLAELREASEALRQSVV---PASEHRRLQEEALELRGRAASLEQEVVATG 944
+ + L++L+ EA ++++ + R LQEEA +++ A + VA
Sbjct: 2215 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA-A 2273
Query: 945 KEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQR 1004
+EAARLR E + AL+ EK E Q +
Sbjct: 2274 QEAARLRQLAEEDLAQQRALA---------------------------EKMLKEKMQAVQ 2306
Query: 1005 EALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDK-KITELSK 1063
EA +K+E + Q A++Q R L+ + E+ Q + + + E ++ + E+S
Sbjct: 2307 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2366
Query: 1064 EVFNLKEALKEQPAALATPEVEA--LRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQ 1121
E LK + E A A E +A R Q +++ ++L V L ++ L +
Sbjct: 2367 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--LEIQR 2424
Query: 1122 GQMDEDVQRILSQILQMQR 1140
Q D D +R+ I +++R
Sbjct: 2425 QQSDHDAERLREAIAELER 2443
Score = 75.5 bits (184), Expect = 3e-13
Identities = 212/898 (23%), Positives = 350/898 (38%), Gaps = 137/898 (15%)
Query: 312 ASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQ 371
A + R E R R+E +QK E+ R+++ + E + L+ +V+E +
Sbjct: 1951 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE--EVERLKAKVEEAR 2008
Query: 372 QLLVE-RQEEKESLGREVESLQSRLSLLENE-----RENTSYDVTTLQDEEGELPDLPGA 425
+L QE L E+ Q RL E ++ TLQ E+ L L G
Sbjct: 2009 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG- 2067
Query: 426 EVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIP 485
E +R+ + A+E + + A RQ +E Q E E+ + + + +A AE
Sbjct: 2068 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAE--- 2122
Query: 486 LALYDSLRAEFDQLRRQHAEALQA-LRQQETREVPREEGAACGESEVAGATATKNGPTHM 544
LR E +Q + A+A QA LRQ++ + E+ + A T +
Sbjct: 2123 -----KLRKEAEQEAARRAQAEQAALRQKQAADAEMEK-----HKKFAEQTLRQKAQVEQ 2172
Query: 545 ELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGA 604
EL ++ ET ++ DE E + ++AEAT A ++ E +
Sbjct: 2173 ELT-----TLRLQLEETDHQKNLLDE--ELQRLKAEATEAARQRSQV------EEELFSV 2219
Query: 605 EVREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEP 664
V+ E ++ +A +E + D + T + EA K K E V A +A
Sbjct: 2220 RVQMEELSKLKARIEAENRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAAR 2278
Query: 665 PVTGTTNMEATGSRATGMESTGVSATGV-ENPGVEATVPGISAGPILHPGAA----EASE 719
+ + RA + V E ++A + L A E E
Sbjct: 2279 -LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2337
Query: 720 KLQVELETRIRGLE---EALRQREREAAAELE------AALGKCEA-AEAEAGRLRERVR 769
++ +L +G + EA RQR+ E +AE E A + + +A AE +A R R +
Sbjct: 2338 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR---K 2394
Query: 770 EAEGSGASGGGGGDTTQLRAALEQAREDLR---DRDS-RLRE----LEAASACLD-EARA 820
+AE G TQ + L Q E R D D+ RLRE LE L EA+
Sbjct: 2395 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2454
Query: 821 SRLLAEE-----------EARGLRAELAQREEARLEQSRELE--------VLREQLATAR 861
+L +EE E + L+ +++ L++ R +E + ++++A A+
Sbjct: 2455 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2514
Query: 862 ATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRR 921
E+Q+ ++ + R L A+ EEAR+ E E ++ + + RR
Sbjct: 2515 QLREEQQRQQQQMEQERQ-------RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2567
Query: 922 LQEEALELRGRAASLEQEVVATGKEAARLRAELE-RERVCSVALSEHERIVGTLQANVAQ 980
QEE L +E RLR +L+ E AL+ E + + A
Sbjct: 2568 QQEELL----------------AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2611
Query: 981 LEGQLEEL-GRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLR---GLRTEAER 1036
L + L G E F R + S + EA + +AE+ R G T E
Sbjct: 2612 LPNGRDALDGPAAEAEPEHSFDGLRRKV---SAQRLQEAGILSAEELQRLAQGHTTVDEL 2668
Query: 1037 ARQ------AQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVEA---- 1086
AR+ Q R+ A K ++K++ + L+ L AL E +A
Sbjct: 2669 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAA----LQRQLLSPGTALILLEAQAASGF 2724
Query: 1087 LRDQVKDLQQQLQEAARDHSSVVALYRSHLLY----AIQGQMDEDVQRILSQILQMQR 1140
L D V++ + + EA ++ VV H L A+ G D + +S MQ+
Sbjct: 2725 LLDPVRNRRLTVNEAVKE--GVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQK 2780
Score = 72.8 bits (177), Expect = 2e-12
Identities = 170/719 (23%), Positives = 267/719 (37%), Gaps = 77/719 (10%)
Query: 270 AQRPSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRL 329
A R +A E EA + S ++ A ++RKA +A R
Sbjct: 1955 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2014
Query: 330 RQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVE 389
QE R LQ L Q +++ ++ E + ++++ QELQQ L + Q + L E E
Sbjct: 2015 EQESARQLQ----LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2070
Query: 390 SLQSRLSLLENERENTSYDV--TTLQDEEGELPDLPGAEVLLSRQLSPSAQEHLASLQEQ 447
+ + E R + + Q EE E E +R + +A E L EQ
Sbjct: 2071 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2130
Query: 448 VAV--------LTRQNQ----ELMEKVQILENFEKDETQMEVEALAEVIPLALYDSLRAE 495
A RQ Q E+ + + E + + Q+E E + L D +
Sbjct: 2131 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2190
Query: 496 FDQ-LRRQHAEALQALRQQETRE-------VPREEGA---ACGESEVAGATATKNGPTHM 544
D+ L+R AEA +A RQ+ E V EE + A E+E T
Sbjct: 2191 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2250
Query: 545 ELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAK----VTETK 600
L A + K E A E R + E + AE + V E
Sbjct: 2251 FLQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2309
Query: 601 PTGAEV----REMETTEEEAN--METKPTGAQATDTETTGVEA-----------MGVEAT 643
AE ++ E +E+A E K AQ ET G + M EA
Sbjct: 2310 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2369
Query: 644 KTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRATGME-STGVSATGVENPGVEATVP 702
+ K AEM A E E G + E +T T V+ ++
Sbjct: 2370 RLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2427
Query: 703 GISAGPILHPGAAEASEKLQVELETRIRGLE-EALRQREREAAAELEAALGKCEAAEAEA 761
A + A EK +++ E ++ L+ E ++ ++E + AL + +E ++
Sbjct: 2428 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2487
Query: 762 GRLRERVREAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRL-RELEAASACLDEARA 820
RER E E + + A +Q RE+ + + ++ +E + A ++EAR
Sbjct: 2488 LLQRERFIEQEKAKLEQLFQDEV----AKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2543
Query: 821 SRLLAEEEARGLRAELAQREEARLEQS-----------RELEVLREQLATARATGEQ--- 866
+ AEE R + EL Q E+ R +Q +L++L EQ A A E+
Sbjct: 2544 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2603
Query: 867 -QRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRRLQE 924
Q A L RDA + AE A E + GL A ++ A E +RL +
Sbjct: 2604 SQVAATKTLPNGRDALDGPAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2660
Score = 72.4 bits (176), Expect = 2e-12
Identities = 77/298 (25%), Positives = 128/298 (42%), Gaps = 23/298 (7%)
Query: 838 QREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQ 897
+ EE EQ R E RE+LA A E+QR A +A+ AE EL +E
Sbjct: 1331 EEEERLAEQQRAEE--RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--- 1385
Query: 898 GLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERE 957
E+ EA +V + R +QEE +LR + + Q + A R R +E E
Sbjct: 1386 ---EVVRREEA---AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1439
Query: 958 -RVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAA 1016
RV + L ER G + + L + EE + + E +++R+ + A
Sbjct: 1440 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1499
Query: 1017 EAQLATAEQQLRGLRTEAERARQAQSRAQEALD----KAKEKDKKITELSKEVFNLKEAL 1072
E +LA+ ++ EAE AR+ Q RA +AL+ +A+E ++++ + E +
Sbjct: 1500 EVELASR------VKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVERARQVQVA 1552
Query: 1073 KEQPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDVQR 1130
E A E+++ R + QL+ + ++ VA R Q Q + + R
Sbjct: 1553 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1610
Score = 38.5 bits (88), Expect = 0.037
Identities = 76/332 (22%), Positives = 131/332 (39%), Gaps = 42/332 (12%)
Query: 786 QLRAALEQ-AREDLRDRD--SRLRELEAASACLDEARASRL---LAEEEARGLRAELAQR 839
QL +LEQ A+E+ R + S L+++ + RL L +E AR +A++
Sbjct: 953 QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ 1012
Query: 840 EEARLEQSRELEVLREQLATARATGEQQRTAAAELGRA---RDAAEARVAELPAACEEAR 896
++A+ E +E L + +A A E+ A R E + +L +
Sbjct: 1013 QKAQAE----VEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1068
Query: 897 QGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELER 956
L +L+ S +R A E R EE L+ + E+ AT +LRA+ E
Sbjct: 1069 IYLEKLKTISLVIR-GTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1127
Query: 957 ERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAA 1016
++ AL + R AQ G E L +RH + EV + + + A
Sbjct: 1128 QQPTFDALRDELR--------GAQEVG--ERLQQRHGERDVEVERWRERVAQLLERWQAV 1177
Query: 1017 EAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP 1076
AQ +++L L + R++ L A+ + +EQ
Sbjct: 1178 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR------------------QEQI 1219
Query: 1077 AALATPEVEALRDQVKDLQQQLQEAARDHSSV 1108
A+ + +A+R+Q++ Q L+E R V
Sbjct: 1220 QAMPLADSQAVREQLRQEQALLEEIERHGEKV 1251
Score = 37.7 bits (86), Expect = 0.063
Identities = 59/266 (22%), Positives = 101/266 (37%), Gaps = 45/266 (16%)
Query: 886 AELPAACEEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQ---EVVA 942
A+ + C+ L ++R EA V +E A E R A ++ EV
Sbjct: 962 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1021
Query: 943 TGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLE---------------- 986
GK ARL AE E+ +AL E TL++ + G+LE
Sbjct: 1022 LGKGVARLSAEAEKV----LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1077
Query: 987 -----------ELGRRHEK-------TSAEVFQVQREALFMKSERHAAEAQLATAE---Q 1025
E+ R HE+ A + +++ +K R AEAQ T +
Sbjct: 1078 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1137
Query: 1026 QLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVE 1085
+LRG + ER +Q +++ +E+ ++ E + V + + + L ++
Sbjct: 1138 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR-QLR 1196
Query: 1086 ALRDQVKDLQQQLQEAARDHSSVVAL 1111
R+ L LQ+A R + A+
Sbjct: 1197 YYRESADPLGAWLQDARRRQEQIQAM 1222
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 126 bits (316), Expect = 1e-28
Identities = 225/948 (23%), Positives = 364/948 (38%), Gaps = 165/948 (17%)
Query: 318 DDRDAYEEIVRLRQERGRLLQKIRGLEQHKER--RQQESPEASSLHILERQVQELQQLLV 375
D R Y E+ L + + + + + +ER QQ + E L +E +++ +QL
Sbjct: 1345 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE 1404
Query: 376 ERQEEKESLGREVESLQSRLSLLENERENTSYDVT----TLQDEEGELPDLPGAEVLLSR 431
+ K RE + LQ R+ RE + D ++Q+E +L AE+
Sbjct: 1405 AHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1464
Query: 432 QLSPSAQEHLASLQEQVAVL----------------------------TRQNQELMEKVQ 463
+ + +A+ ++E++ V+ Q ++ E+ +
Sbjct: 1465 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1524
Query: 464 ILENFEKDETQMEVEALAEVIPLALYDSLRAEFDQLRRQHAEALQALRQQETREVPREEG 523
L +DE+Q + +A E+ ++ A Q Q E L+ ++ R + + E
Sbjct: 1525 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1584
Query: 524 AACGESEVAGATATKNGPTHMELNGSVAPETKVNGAETIDEEAAG-----DETMEARTME 578
+ +VA TA ++ ++ + E ++ EE +E +
Sbjct: 1585 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1644
Query: 579 AEATGA----------------EATGAEATGAKVTETKPTGAEVREMETTEEEANMETKP 622
AEA A EA +V + K E E +EEA E +
Sbjct: 1645 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ--AEAEKQKEEAEREARR 1702
Query: 623 TGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAE------PPVTGTTNMEATG 676
G + + + + + + + AE A A + E G +
Sbjct: 1703 RG--KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1760
Query: 677 SRATGMESTGVSATGVENPGVEATVPGISAG-PILHPGAAEA-------SEKLQVELE-- 726
++ +AT + +EA + + A +L A A SEK + LE
Sbjct: 1761 EELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1819
Query: 727 -----------TRIRGL-EEALRQR---EREAA---AELEAALGKCEAAEAEAGRLRE-- 766
R+R L EEA RQR E +AA AE E L + AA EA RL+
Sbjct: 1820 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1879
Query: 767 ----RVREAEGSGASGGGGGDTTQLRAALEQA---REDLRDRDSRLR-----ELEAASAC 814
+ +EAE + Q R EQA + D+ +R ++LR ELE
Sbjct: 1880 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL 1939
Query: 815 LDEARASRLLAEEEARGLRAELAQREEARLEQSRELEVLREQLATARATGEQ-------Q 867
+++ R EEE L+A + + E EL +R + EQ Q
Sbjct: 1940 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1999
Query: 868 RTAAAELGRARDAAEARVAELPAACEE-ARQGLAELREASEALRQSVVPASEHRRLQEEA 926
R AAE R R AE RV + AA EE ARQ A L E E L+ V E RRL+E A
Sbjct: 2000 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV-ERLKAKV---EEARRLRERA 2055
Query: 927 LELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHERIVGTLQAN---VAQLEG 983
+ R L Q EAA+ R + E + + + + TLQ + QL G
Sbjct: 2056 EQESARQLQLAQ-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2108
Query: 984 QLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRG----------LRTE 1033
+ E R E+ Q +REA + + AE +AE+Q + LR E
Sbjct: 2109 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2168
Query: 1034 AE-------RARQAQSRAQEALDKAKEKDKKITE--------LSKEVFNLKEALKEQPAA 1078
AE +A QA R ++A D EK KK E + +E+ L+ L+E
Sbjct: 2169 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE---- 2224
Query: 1079 LATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDE 1126
+ L ++++ L+ + EAAR S V L++++ QM+E
Sbjct: 2225 -TDHQKNLLDEELQRLKAEATEAARQRSQV-----EEELFSVRVQMEE 2266
Score = 107 bits (266), Expect = 8e-23
Identities = 226/919 (24%), Positives = 366/919 (39%), Gaps = 134/919 (14%)
Query: 257 AGDKLILHL-LQEAAQRPSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPP---- 311
A + L L L +E AQ+ S A E EA + ++ A ++R+
Sbjct: 1665 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1724
Query: 312 ---ASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQ 368
A A +E++RLR E + Q+ + LE+ R Q+E+ A+ ++ Q
Sbjct: 1725 RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT------QKRQ 1778
Query: 369 ELQQLLVERQEEKESLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVL 428
EL+ L + + E E L L S+ E R + L+ E G +L E
Sbjct: 1779 ELEAELAKVRAEMEVL------LASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAA 1831
Query: 429 LSRQLSPSAQEHLASLQEQVAVLTRQNQE----LMEKVQILENFEKDETQMEVEALAEVI 484
R L+ A+ +E A RQ E L EK+ + + +T+ E+ AL E
Sbjct: 1832 RLRALAEEAKRQRQLAEEDAA---RQRAEAERVLAEKLAAIGEATRLKTEAEI-ALKE-- 1885
Query: 485 PLALYDSLRAEFDQLRR-QHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTH 543
AE ++LRR EA Q R EE AA ++++
Sbjct: 1886 -------KEAENERLRRLAEDEAFQRRR--------LEEQAAQHKADI------------ 1918
Query: 544 MELNGSVAPETKVNGAETIDEEAAGDETM-EARTMEAEATGAEATGAEATGAKVTETKPT 602
+A K + +E ++ ++T+ + R +E E +A+ +A K
Sbjct: 1919 ---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELEL 1975
Query: 603 GAEVREMETT---EEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGA 659
G E T +E+A +E A + E EA E K+ AE +A A
Sbjct: 1976 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA---EERVQKSLAAEEEA----A 2028
Query: 660 GQAEPPVTGTTNMEATGSRATGMESTGVSATGVE-NPGVEATVPGISAGPILHPGAAEAS 718
Q + + ++A A + + + EA + A H A +
Sbjct: 2029 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2088
Query: 719 EKLQVELETRIRGLEEALRQREREAAAELEAALGKCEA---AEAEAGRLRERVREAEGSG 775
E+ EL+ ++ + L Q EA A AA EA AE EA + R +V EAE
Sbjct: 2089 EQ---ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2145
Query: 776 ASGGGGGDTTQLRAALEQAREDLRD--RDSRLRELEAASACLDEARASRLLAEEEARGLR 833
S + Q RA + A E LR R +A A L + +A+ AE E
Sbjct: 2146 QS---AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD--AEMEKHKKF 2200
Query: 834 AELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRAR-DAAEA-----RVAE 887
AE R++A++EQ EL LR QL T Q+ EL R + +A EA +V E
Sbjct: 2201 AEQTLRQKAQVEQ--ELTTLRLQL---EETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2255
Query: 888 LPAACEEARQGLAELREASEALRQSVV---PASEHRRLQEEALELRGRAASLEQEVVATG 944
+ + L++L+ EA ++++ + R LQEEA +++ A + VA
Sbjct: 2256 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA-A 2314
Query: 945 KEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQR 1004
+EAARLR E + AL+ EK E Q +
Sbjct: 2315 QEAARLRQLAEEDLAQQRALA---------------------------EKMLKEKMQAVQ 2347
Query: 1005 EALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDK-KITELSK 1063
EA +K+E + Q A++Q R L+ + E+ Q + + + E ++ + E+S
Sbjct: 2348 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2407
Query: 1064 EVFNLKEALKEQPAALATPEVEA--LRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQ 1121
E LK + E A A E +A R Q +++ ++L V L ++ L +
Sbjct: 2408 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT--LEIQR 2465
Query: 1122 GQMDEDVQRILSQILQMQR 1140
Q D D +R+ I +++R
Sbjct: 2466 QQSDHDAERLREAIAELER 2484
Score = 75.5 bits (184), Expect = 3e-13
Identities = 212/898 (23%), Positives = 350/898 (38%), Gaps = 137/898 (15%)
Query: 312 ASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQ 371
A + R E R R+E +QK E+ R+++ + E + L+ +V+E +
Sbjct: 1992 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE--EVERLKAKVEEAR 2049
Query: 372 QLLVE-RQEEKESLGREVESLQSRLSLLENE-----RENTSYDVTTLQDEEGELPDLPGA 425
+L QE L E+ Q RL E ++ TLQ E+ L L G
Sbjct: 2050 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG- 2108
Query: 426 EVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIP 485
E +R+ + A+E + + A RQ +E Q E E+ + + + +A AE
Sbjct: 2109 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE--EQAQARAQAQAAAE--- 2163
Query: 486 LALYDSLRAEFDQLRRQHAEALQA-LRQQETREVPREEGAACGESEVAGATATKNGPTHM 544
LR E +Q + A+A QA LRQ++ + E+ + A T +
Sbjct: 2164 -----KLRKEAEQEAARRAQAEQAALRQKQAADAEMEK-----HKKFAEQTLRQKAQVEQ 2213
Query: 545 ELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGA 604
EL ++ ET ++ DE E + ++AEAT A ++ E +
Sbjct: 2214 ELT-----TLRLQLEETDHQKNLLDE--ELQRLKAEATEAARQRSQV------EEELFSV 2260
Query: 605 EVREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEP 664
V+ E ++ +A +E + D + T + EA K K E V A +A
Sbjct: 2261 RVQMEELSKLKARIEAENRALILRDKDNTQ-RFLQEEAEKMKQVAEEAARLSVAAQEAAR 2319
Query: 665 PVTGTTNMEATGSRATGMESTGVSATGV-ENPGVEATVPGISAGPILHPGAA----EASE 719
+ + RA + V E ++A + L A E E
Sbjct: 2320 -LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2378
Query: 720 KLQVELETRIRGLE---EALRQREREAAAELE------AALGKCEA-AEAEAGRLRERVR 769
++ +L +G + EA RQR+ E +AE E A + + +A AE +A R R +
Sbjct: 2379 QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR---K 2435
Query: 770 EAEGSGASGGGGGDTTQLRAALEQAREDLR---DRDS-RLRE----LEAASACLD-EARA 820
+AE G TQ + L Q E R D D+ RLRE LE L EA+
Sbjct: 2436 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2495
Query: 821 SRLLAEE-----------EARGLRAELAQREEARLEQSRELE--------VLREQLATAR 861
+L +EE E + L+ +++ L++ R +E + ++++A A+
Sbjct: 2496 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2555
Query: 862 ATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRR 921
E+Q+ ++ + R L A+ EEAR+ E E ++ + + RR
Sbjct: 2556 QLREEQQRQQQQMEQERQ-------RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2608
Query: 922 LQEEALELRGRAASLEQEVVATGKEAARLRAELE-RERVCSVALSEHERIVGTLQANVAQ 980
QEE L +E RLR +L+ E AL+ E + + A
Sbjct: 2609 QQEELL----------------AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2652
Query: 981 LEGQLEEL-GRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLR---GLRTEAER 1036
L + L G E F R + S + EA + +AE+ R G T E
Sbjct: 2653 LPNGRDALDGPAAEAEPEHSFDGLRRKV---SAQRLQEAGILSAEELQRLAQGHTTVDEL 2709
Query: 1037 ARQ------AQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVEA---- 1086
AR+ Q R+ A K ++K++ + L+ L AL E +A
Sbjct: 2710 ARREDVRHYLQGRSSIAGLLLKATNEKLSVYAA----LQRQLLSPGTALILLEAQAASGF 2765
Query: 1087 LRDQVKDLQQQLQEAARDHSSVVALYRSHLLY----AIQGQMDEDVQRILSQILQMQR 1140
L D V++ + + EA ++ VV H L A+ G D + +S MQ+
Sbjct: 2766 LLDPVRNRRLTVNEAVKE--GVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQK 2821
Score = 72.8 bits (177), Expect = 2e-12
Identities = 170/719 (23%), Positives = 267/719 (37%), Gaps = 77/719 (10%)
Query: 270 AQRPSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRL 329
A R +A E EA + S ++ A ++RKA +A R
Sbjct: 1996 AARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERA 2055
Query: 330 RQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVE 389
QE R LQ L Q +++ ++ E + ++++ QELQQ L + Q + L E E
Sbjct: 2056 EQESARQLQ----LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2111
Query: 390 SLQSRLSLLENERENTSYDV--TTLQDEEGELPDLPGAEVLLSRQLSPSAQEHLASLQEQ 447
+ + E R + + Q EE E E +R + +A E L EQ
Sbjct: 2112 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2171
Query: 448 VAV--------LTRQNQ----ELMEKVQILENFEKDETQMEVEALAEVIPLALYDSLRAE 495
A RQ Q E+ + + E + + Q+E E + L D +
Sbjct: 2172 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2231
Query: 496 FDQ-LRRQHAEALQALRQQETRE-------VPREEGA---ACGESEVAGATATKNGPTHM 544
D+ L+R AEA +A RQ+ E V EE + A E+E T
Sbjct: 2232 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291
Query: 545 ELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAK----VTETK 600
L A + K E A E R + E + AE + V E
Sbjct: 2292 FLQEE-AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2350
Query: 601 PTGAEV----REMETTEEEAN--METKPTGAQATDTETTGVEA-----------MGVEAT 643
AE ++ E +E+A E K AQ ET G + M EA
Sbjct: 2351 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2410
Query: 644 KTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRATGME-STGVSATGVENPGVEATVP 702
+ K AEM A E E G + E +T T V+ ++
Sbjct: 2411 RLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2468
Query: 703 GISAGPILHPGAAEASEKLQVELETRIRGLE-EALRQREREAAAELEAALGKCEAAEAEA 761
A + A EK +++ E ++ L+ E ++ ++E + AL + +E ++
Sbjct: 2469 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2528
Query: 762 GRLRERVREAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRL-RELEAASACLDEARA 820
RER E E + + A +Q RE+ + + ++ +E + A ++EAR
Sbjct: 2529 LLQRERFIEQEKAKLEQLFQDEV----AKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2584
Query: 821 SRLLAEEEARGLRAELAQREEARLEQS-----------RELEVLREQLATARATGEQ--- 866
+ AEE R + EL Q E+ R +Q +L++L EQ A A E+
Sbjct: 2585 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2644
Query: 867 -QRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRRLQE 924
Q A L RDA + AE A E + GL A ++ A E +RL +
Sbjct: 2645 SQVAATKTLPNGRDALDGPAAE--AEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2701
Score = 72.4 bits (176), Expect = 2e-12
Identities = 77/298 (25%), Positives = 128/298 (42%), Gaps = 23/298 (7%)
Query: 838 QREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQ 897
+ EE EQ R E RE+LA A E+QR A +A+ AE EL +E
Sbjct: 1372 EEEERLAEQQRAEE--RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE--- 1426
Query: 898 GLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERE 957
E+ EA +V + R +QEE +LR + + Q + A R R +E E
Sbjct: 1427 ---EVVRREEA---AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1480
Query: 958 -RVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAA 1016
RV + L ER G + + L + EE + + E +++R+ + A
Sbjct: 1481 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1540
Query: 1017 EAQLATAEQQLRGLRTEAERARQAQSRAQEALD----KAKEKDKKITELSKEVFNLKEAL 1072
E +LA+ ++ EAE AR+ Q RA +AL+ +A+E ++++ + E +
Sbjct: 1541 EVELASR------VKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVERARQVQVA 1593
Query: 1073 KEQPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDVQR 1130
E A E+++ R + QL+ + ++ VA R Q Q + + R
Sbjct: 1594 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1651
Score = 38.5 bits (88), Expect = 0.037
Identities = 76/332 (22%), Positives = 131/332 (39%), Gaps = 42/332 (12%)
Query: 786 QLRAALEQ-AREDLRDRD--SRLRELEAASACLDEARASRL---LAEEEARGLRAELAQR 839
QL +LEQ A+E+ R + S L+++ + RL L +E AR +A++
Sbjct: 994 QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ 1053
Query: 840 EEARLEQSRELEVLREQLATARATGEQQRTAAAELGRA---RDAAEARVAELPAACEEAR 896
++A+ E +E L + +A A E+ A R E + +L +
Sbjct: 1054 QKAQAE----VEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1109
Query: 897 QGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELER 956
L +L+ S +R A E R EE L+ + E+ AT +LRA+ E
Sbjct: 1110 IYLEKLKTISLVIR-GTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1168
Query: 957 ERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAA 1016
++ AL + R AQ G E L +RH + EV + + + A
Sbjct: 1169 QQPTFDALRDELR--------GAQEVG--ERLQQRHGERDVEVERWRERVAQLLERWQAV 1218
Query: 1017 EAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP 1076
AQ +++L L + R++ L A+ + +EQ
Sbjct: 1219 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR------------------QEQI 1260
Query: 1077 AALATPEVEALRDQVKDLQQQLQEAARDHSSV 1108
A+ + +A+R+Q++ Q L+E R V
Sbjct: 1261 QAMPLADSQAVREQLRQEQALLEEIERHGEKV 1292
Score = 37.7 bits (86), Expect = 0.063
Identities = 59/266 (22%), Positives = 101/266 (37%), Gaps = 45/266 (16%)
Query: 886 AELPAACEEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQ---EVVA 942
A+ + C+ L ++R EA V +E A E R A ++ EV
Sbjct: 1003 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1062
Query: 943 TGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLE---------------- 986
GK ARL AE E+ +AL E TL++ + G+LE
Sbjct: 1063 LGKGVARLSAEAEKV----LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1118
Query: 987 -----------ELGRRHEK-------TSAEVFQVQREALFMKSERHAAEAQLATAE---Q 1025
E+ R HE+ A + +++ +K R AEAQ T +
Sbjct: 1119 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1178
Query: 1026 QLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVE 1085
+LRG + ER +Q +++ +E+ ++ E + V + + + L ++
Sbjct: 1179 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR-QLR 1237
Query: 1086 ALRDQVKDLQQQLQEAARDHSSVVAL 1111
R+ L LQ+A R + A+
Sbjct: 1238 YYRESADPLGAWLQDARRRQEQIQAM 1263
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 118 bits (296), Expect = 3e-26
Identities = 224/923 (24%), Positives = 355/923 (38%), Gaps = 163/923 (17%)
Query: 330 RQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVE 389
RQE+ R E R Q+E EA++ H E V+ LQ+ + ++++S RE E
Sbjct: 1102 RQEQDRSTVNALTSELRDLRAQRE--EAAAAHAQE--VRRLQEQARDLGKQRDSCLREAE 1157
Query: 390 SLQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSAQEHLASLQEQVA 449
L+++L LLE+ R+ ++ Q + E + G EV RQ + + L ++
Sbjct: 1158 ELRTQLRLLEDARDGLRRELLEAQRKLRESQE--GREV--QRQEAGELRRSLGEGAKERE 1213
Query: 450 VLTRQNQELMEKVQILENFE-----KDETQMEVEALAEVIPLAL---YDSLRAEFDQLRR 501
L R N+EL V+ E+ +E + + AL E A+ LR ++ R
Sbjct: 1214 ALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVER 1273
Query: 502 QHAEA---LQALRQQET----------REVPREEGA-ACGESEVAGATATKNGPTHMELN 547
EA LQ LR+Q RE+ +G A GE + G L
Sbjct: 1274 SRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLK 1333
Query: 548 GSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGA--EATGAEATGAKVTETKPTGAE 605
G + E + + E E RT E G+ EA G E E
Sbjct: 1334 GEASLEVMRQELQVAQRKLQEQEG-EFRTRERRLLGSLEEARGTEKQQLDHARGLELKLE 1392
Query: 606 VREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPP 665
E E + AQ + E VE A G+G G+A P
Sbjct: 1393 AARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSP 1452
Query: 666 VTGTTNMEATGSRATGMESTGVSATGVENPGVEATVPGI---SAGPILHPGAAEAS-EKL 721
GS A + G S G+ +P PG S GP P + + E +
Sbjct: 1453 AP----RPVPGSPARDAPAEG-SGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAV 1507
Query: 722 QVELETRIRGLEEALRQRE--REAAAELEAALGKCEA----AEAEAGRLRERVREAEGSG 775
+ L ++ L A R+R+ R + L L + EA A + A +L++ V E+E +
Sbjct: 1508 RGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEAR 1567
Query: 776 ASGGGGGDTTQLRAAL--EQAREDLRDRDSRL-------RELEAASACL----------- 815
S G Q AL E R R+R + L R L+A + L
Sbjct: 1568 RSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMK 1627
Query: 816 --------DEARASRLLAEEEARGLRAELAQRE-EARLEQSR---------------ELE 851
D+ R +L E+R ++ EL +R E L++SR ++
Sbjct: 1628 ANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVD 1687
Query: 852 VLREQLA-------TARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELRE 904
L+ Q+A T + T E+ A A++ + A +V L A ++ L R+
Sbjct: 1688 SLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRD 1747
Query: 905 ASEALRQSVVPASEHRRLQEEALE----------------------LRGRAASLE-QEVV 941
+ L++++ R++ +E L+ LRG A LE Q V
Sbjct: 1748 KNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVE 1807
Query: 942 ATG-----KEAARLRAELERERVCSVALSEHERIV-----GTLQANVAQLEGQLEE---- 987
A G +E R R E E + +V + ER + G+LQ +AQLE + E
Sbjct: 1808 AEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERS 1867
Query: 988 ----------LGRRHEKTSAEVFQVQREALFMKSERH-------AAEAQLATAEQQLRGL 1030
L R +K E + + + + +E+ AE +LA A++Q++ L
Sbjct: 1868 ALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQL 1927
Query: 1031 RTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPE------V 1084
+ Q+ S AQ +D +++ EL +EV L+ A + L E V
Sbjct: 1928 EAQVVVLEQSHSPAQLEVDAQQQQ----LELQQEVERLRSAQAQTERTLEARERAHRQRV 1983
Query: 1085 EALRDQVKDLQQQLQEAARDHSS 1107
L +QV L+ QLQ+ R S+
Sbjct: 1984 RGLEEQVSTLKGQLQQELRRSSA 2006
Score = 101 bits (251), Expect = 5e-21
Identities = 201/852 (23%), Positives = 337/852 (39%), Gaps = 122/852 (14%)
Query: 322 AYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASS-----LHILERQVQELQQL--- 373
A ++ LRQER +L L + ++R ++E +A LER ++L+QL
Sbjct: 615 AQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGK 674
Query: 374 -------LVERQE-------EKESLGREVESLQSRLSLLENERENTSYDVTTLQDEEGEL 419
LVE +E +++ L E + L+ E R +T L+ EE L
Sbjct: 675 RSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASL 734
Query: 420 PDLPGAEVLLSRQLSPSA----------QEHLASLQ------EQVAVLTRQNQELMEKVQ 463
D L+ L+ +E ++LQ EQ A + R+ QE +E+++
Sbjct: 735 QDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELR 794
Query: 464 ILENFEKD--ETQMEV-----EALAEVIPLALYD--SLRAEFDQLRRQHAEALQALRQQE 514
+ + + E + V EAL + +P ++ L+ + QL RQ + Q L +Q
Sbjct: 795 LEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQEL-EQA 853
Query: 515 TREVPREEGAACGESEVAGATATKNGPTHMELNGSVAPETKVNGAET---IDEEAAGDET 571
RE R+ A + A A ++ ++L + ++ T +++EA
Sbjct: 854 RREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSL 913
Query: 572 MEART----MEAEATGAEATGAEATGAKVTETKPTGAEVREMETTEEEANMETKPTGAQA 627
E + +EA EA G AK T T +++ T+E+A+++ + +
Sbjct: 914 FEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKL 973
Query: 628 TDTETTGVEAMGVEATKTKAEEAEMQAYGVGAG---QAEPPVTGTTNMEATGSRATGMES 684
E ++ + + + +Q A +AE + +E+
Sbjct: 974 VQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEA 1033
Query: 685 TGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIRGLEEAL-------R 737
+ + G+ A E + L ++ G +L
Sbjct: 1034 EKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEME 1093
Query: 738 QREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGDTTQLRAALEQARED 797
+++R+A + E A +E LR + EA + A ++R EQAR+
Sbjct: 1094 RQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQ--------EVRRLQEQARDL 1145
Query: 798 LRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAEL--AQR-----EEARLEQSREL 850
+ RDS LRE E E R L E+ GLR EL AQR +E R Q +E
Sbjct: 1146 GKQRDSCLREAE-------ELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEA 1198
Query: 851 EVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALR 910
LR L E R + EL A AE+ L A E+ Q LA L EA A
Sbjct: 1199 GELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTA-- 1256
Query: 911 QSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHERI 970
+ +EA ELR QEV + EA R EL R+ + SE+ R
Sbjct: 1257 -----------VGKEAGELRTGL----QEVERSRLEARRELQELRRQ--MKMLDSENTR- 1298
Query: 971 VGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQL--- 1027
L +A+L+G+L LG R EK S +RE L ++ EA L Q+L
Sbjct: 1299 ---LGRELAELQGRL-ALGERAEKES------RRETLGLRQRLLKGEASLEVMRQELQVA 1348
Query: 1028 -RGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVEA 1086
R L+ + R + R +L++A+ +K+ + ++ + EA + + A L + A
Sbjct: 1349 QRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGL-RLSA 1407
Query: 1087 LRDQVKDLQQQL 1098
+ + L+ +L
Sbjct: 1408 AEGRAQGLEAEL 1419
Score = 95.9 bits (237), Expect = 2e-19
Identities = 199/884 (22%), Positives = 343/884 (38%), Gaps = 101/884 (11%)
Query: 294 SSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKER---- 349
SS G+ +P R+ P P S D I +R +Q +RG + +
Sbjct: 499 SSPGRGRSP--RRGPSPACS-----DSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGT 551
Query: 350 -RQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVESLQSRLSLLENERENTSYD 408
R+Q S S LE Q+Q L+ + E REV+ L+S LL E+ N ++
Sbjct: 552 LRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHS 611
Query: 409 VTTLQDEEGELPDLPGAEVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENF 468
+ Q + EL R+ +AQE L ++++ Q + + ++
Sbjct: 612 LQVAQQQAEELRQ--------EREKLQAAQEELRRQRDRLE--EEQEDAVQDGARVRREL 661
Query: 469 EKDETQME-VEALAEVIPLALYDSLRA------EFDQLRRQHAEALQALRQQETREVPRE 521
E+ Q+E +E V+ L + A + D L+ + AE +AL + E V E
Sbjct: 662 ERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELE 721
Query: 522 EGAACGESEVAGATATKNGPTHMELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEA 581
+E A + + + LN S+A + K++ + + ++ R +AE
Sbjct: 722 LSMTKLRAEEASLQDSLSKLS--ALNESLA-QDKLDLNRLVAQLEEEKSALQGRQRQAE- 777
Query: 582 TGAEATGAEATGAKVTETKPTGAEVREMETTEEEANMETKPTGAQATDTETTGVEAMGVE 641
EAT A+ + + + E+ +E A + + A + EA+ +
Sbjct: 778 -------QEATVAREEQER-----LEELRLEQEVARQGLEGSLRVAEQAQ----EALEQQ 821
Query: 642 ATKTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRATGMESTGVSATGVENPGVEATV 701
+ E +++Q Q ++G R + + E +
Sbjct: 822 LPTLRHERSQLQEQ---LAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEH 878
Query: 702 PGISAGPILHPGAAEASEKLQVELETRIRGLEEALRQREREAAAELEAALGKCEAAEAEA 761
G++ + AAE + E TR+R +EAL E +L + E EAE
Sbjct: 879 AGLAVQLV----AAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEG 934
Query: 762 GRLRERVREAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRLRELE-AASACLDEARA 820
L G A G Q+ A E+A D +L + E A A L E RA
Sbjct: 935 QALLLAKETLTGELA-----GLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRA 989
Query: 821 SRLLAEEEARGLRAELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDA 880
+ EE+ + L+ E +E A RELE R QL + + QR L R
Sbjct: 990 AH---EEDLQRLQRE---KEAA----WRELEAERAQLQS-----QLQREQEELLARLEAE 1034
Query: 881 AEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEV 940
E E+ A +E +GL L SE + + SE L E+ + R A++ E
Sbjct: 1035 KEELSEEIAALQQERDEGL--LLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLE- 1091
Query: 941 VATGKEAARLRAELERERVCSVA------LSEHERIVGTLQANVAQLEGQLEELGRRHEK 994
+ K A+ R E +R V ++ ++ E V +L+ Q +LG++ +
Sbjct: 1092 MERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDS 1151
Query: 995 TSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEAL-DKAKE 1053
E +++ + ++ R +L A+++LR + E RQ + +L + AKE
Sbjct: 1152 CLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKE 1211
Query: 1054 KD----------KKITELSKEVFNLKEAL--KEQPAALATPEVEALRDQVKDLQQQLQEA 1101
++ + + E +LK A KEQ AL A+ + +L+ LQE
Sbjct: 1212 REALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEV 1271
Query: 1102 ARDHSSVVALYRSHLLYAIQGQMDEDVQRILSQILQMQRLQAQG 1145
R S + A L +D + R+ ++ ++Q A G
Sbjct: 1272 ER--SRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALG 1313
Score = 83.6 bits (205), Expect = 1e-15
Identities = 204/838 (24%), Positives = 333/838 (39%), Gaps = 140/838 (16%)
Query: 345 QHKE---RRQQES------PEASSLHILERQVQELQQLLVERQEEKESLGREVESLQSRL 395
+H+E RR++ES E S L +L RQV ++L+ E K R++ L L
Sbjct: 272 EHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLV---SEVKMFTERDLLQLGGEL 328
Query: 396 SLLENERENTSYDVTT-LQDEEGELPDLPGAEVLLSRQLSPSAQEHLASLQEQVAVLTRQ 454
+ + ++T L+ E AE L +Q AQ L+EQ+ +
Sbjct: 329 ARTSRAVQEAGLGLSTGLRLAESR------AEAALEKQALLQAQ-----LEEQL-----R 372
Query: 455 NQELMEKVQILENFEKDETQMEVEALAEVIPLAL--YDSLRAEFDQLRR---QHAEALQA 509
++ L EK + + D + ++ A + LA+ + E DQ+ + + EAL++
Sbjct: 373 DKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALES 432
Query: 510 LRQQETREVPREEGAACGES--EVAGATATKNGPTHMELNGSVAPETKVNGAETIDEEAA 567
LR QE + E+G ++ ++A A + + + ++L+GS NG+ +
Sbjct: 433 LRLQEQAALETEDGEGLQQTLRDLAQAVLS-DSESGVQLSGSERTADASNGSL---RGLS 488
Query: 568 GDETMEARTMEAEATGAEATGAEATGAKVTETKP---TGAEVREMETTEEEANMETKPTG 624
G T + G + + T + R+++ + E
Sbjct: 489 GQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEA---- 544
Query: 625 AQATDTETTGVEAMGVEATKTKAEEAEMQAY---GVGAGQAEPPVTGTTNMEATGSRATG 681
+ D T + + ++ +A E ++Q GA QA + +
Sbjct: 545 --SQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLS 602
Query: 682 MESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIRGLEEALRQRER 741
E + ++ + L +A E L+ E E EE RQR+R
Sbjct: 603 REKSNLAHS-------------------LQVAQQQAEE-LRQEREKLQAAQEELRRQRDR 642
Query: 742 EAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGDTTQLRAALEQAREDLRDR 801
E E A+ E R ++ + EG + + ++R AL +A R
Sbjct: 643 -LEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSV--LAKELVEVREALSRA---TLQR 696
Query: 802 DSRLRELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQSRELEVL-REQLATA 860
D E + L +A A R+ E LRAE A +++ + S E L +++L
Sbjct: 697 DMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLN 756
Query: 861 RATGEQQRTAAAELGRARDA---------AEARVAELPAACEEARQGL-AELR---EASE 907
R + + +A GR R A + R+ EL E ARQGL LR +A E
Sbjct: 757 RLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQE 816
Query: 908 ALRQSVVPASEHRR--LQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSVALS 965
AL Q +P H R LQE+ +L + + EQE+ +EA R LER AL+
Sbjct: 817 ALEQQ-LPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALA 875
Query: 966 -EHERIVGTLQANVAQLEGQL--EELGR-RHEKTSAE--VFQVQREALFMKSERHAAEAQ 1019
EH + +Q A+ EG+ EE R R EK + E +F+VQR+ +++ R EA+
Sbjct: 876 KEHAGL--AVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAE 933
Query: 1020 -------LATAEQQLRGLR---------------------TEAERARQAQSRAQEALDK- 1050
T +L GLR +AER QA R Q A +
Sbjct: 934 GQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEE 993
Query: 1051 -----AKEKDKKITELSKEVFNLKEAL-KEQPAALA--TPEVEALRDQVKDLQQQLQE 1100
+EK+ EL E L+ L +EQ LA E E L +++ LQQ+ E
Sbjct: 994 DLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDE 1051
Score = 58.9 bits (141), Expect = 3e-08
Identities = 140/705 (19%), Positives = 254/705 (36%), Gaps = 118/705 (16%)
Query: 201 LQQGAAANDQDLQGRTALMLACEGASPETVEVLLQGGAQPGITDALGQDAAHY------- 253
L++ Q L L L E A E E+ L+ A G L + A
Sbjct: 1370 LEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAA 1429
Query: 254 -GALAGDKLILHLLQEAAQRPSP-----PSALTEDDSGEASSQNSMSSHGKQGAPKKRKA 307
L G + L + PSP P + D E S + S + +P +
Sbjct: 1430 EAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPP 1489
Query: 308 PPPPASIPMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQV 367
P PA+ P D D LR+ LQ++R ++ ++ L Q
Sbjct: 1490 SPGPATSPASPDLDPEAVRGALRE----FLQELRSAQRERDE-------------LRTQT 1532
Query: 368 QELQQLLVERQEEKESLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEV 427
L + L E + E++S LQ ++ E R + +G L +
Sbjct: 1533 SALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSV----------DGRLSGVQAELA 1582
Query: 428 LLSRQLSPSAQEHLASLQEQVAVLTRQNQ----ELMEKVQILENFEKDETQMEVE--ALA 481
L + S +E A+L +QVA L R Q EL + + + +ET++E + L
Sbjct: 1583 LQEESVRRSERERRATL-DQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLK 1641
Query: 482 EVIPLALYDSLRAEFDQ--LRRQHAEALQALRQQETREVPREEGAACGESEVAGATATKN 539
EV+ + +++ E + L + + L +E + ++ + +VA + K
Sbjct: 1642 EVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVAD-SEVKA 1700
Query: 540 GPTHMELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTET 599
G + + ++NGA EE+ G + + G A+++ A + T
Sbjct: 1701 GTLQLTVE-------RLNGALAKVEESEG-------ALRDKVRGLTEALAQSS-ASLNST 1745
Query: 600 KPTGAEVREMETT---EEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYG 656
+ +++ T + + E QA ++G + + E A+++
Sbjct: 1746 RDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQR 1805
Query: 657 VGAGQAEPPVTGTTNMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAE 716
V A + G A A
Sbjct: 1806 VEAEGQLQQLREVLRQRQEGEAA----------------------------------ALN 1831
Query: 717 ASEKLQVE---LETRIRGLEEALRQREREAAAELEAALGKCEAAEAEAGRL-----RERV 768
+KLQ E L+ R+ L+ AL Q E E E+E + + E R RE++
Sbjct: 1832 TVQKLQDERRLLQERLGSLQRALAQLEAE-KREVERSALRLEKDRVALRRTLDKVEREKL 1890
Query: 769 REAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRLRELEAASACLDEARASRLL---A 825
R E + G +L L A +L + ++++LEA L+++ + L A
Sbjct: 1891 RSHEDTVRLSAEKG---RLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDA 1947
Query: 826 EEEARGLRAELAQREEARLEQSRELEVLREQLATARATGEQQRTA 870
+++ L+ E+ + A+ + R LE RE+ R G +++ +
Sbjct: 1948 QQQQLELQQEVERLRSAQAQTERTLEA-RERAHRQRVRGLEEQVS 1991
Score = 49.7 bits (117), Expect = 2e-05
Identities = 88/357 (24%), Positives = 151/357 (42%), Gaps = 61/357 (17%)
Query: 786 QLRAALEQAREDLRDRDSR--LRELEAASACLDEARAS---RLLAEEEARGLRAELAQRE 840
+L AL +L ++ R +R+ L E +AS +L A +E + +A+L QR
Sbjct: 117 RLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRL 176
Query: 841 EAR-LEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGL 899
+ + L+ + L +QL EQQR E + ++A R+ EE +Q
Sbjct: 177 QGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRL-------EEEQQRS 229
Query: 900 AELREASEALRQSVVPA-SEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERER 958
A L + + LR+ + A S ++ L E+ ++ +E+ +EAA R E E
Sbjct: 230 ASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKEL--EHREAAWRR---EEES 284
Query: 959 VCSVALSEHER-------IVG--TLQANVAQL-EGQLEELGRRHEKTSAEVFQVQREALF 1008
+ +EH R +VG L + V E L +LG +TS V Q L
Sbjct: 285 FNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAV---QEAGLG 341
Query: 1009 MKSERHAAEAQLATAEQQLRGLRTEAERARQ---------AQSRAQEALDKAK------- 1052
+ + AE++ A ++ L+ + E + AQ + Q LDKA
Sbjct: 342 LSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTE 401
Query: 1053 -------------EKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQQ 1096
EKD+ +L++++ L+ ++ AAL T + E L+ ++DL Q
Sbjct: 402 LGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQ 458
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 112 bits (279), Expect = 3e-24
Identities = 71/200 (35%), Positives = 97/200 (48%), Gaps = 1/200 (0%)
Query: 68 IARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMIAHGSNVMSADGAGYNALHLAAKYGH 127
I + G V D G + H+AA G + +I G++ G LHLAA G
Sbjct: 325 IIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGF 384
Query: 128 PQCLKQLLQASCVVDVVDSSGWTALHHAAAGGCLSCSEVLCSFKAHLNPQDRSGATPLII 187
C ++LL + +D D G T LH AAAGG L C +L + A N +D+ G +PL
Sbjct: 385 SDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHY 444
Query: 188 AAQMCHTDLCRLLLQQGAAANDQDLQGRTAL-MLACEGASPETVEVLLQGGAQPGITDAL 246
AA C+ L+ GA+ ND D +G T L A + +E LL+ A PGI D
Sbjct: 445 AAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQ 504
Query: 247 GQDAAHYGALAGDKLILHLL 266
G +A HY A G +L L L+
Sbjct: 505 GYNAVHYSAAYGHRLCLQLI 524
Score = 96.3 bits (238), Expect = 1e-19
Identities = 71/227 (31%), Positives = 110/227 (48%), Gaps = 1/227 (0%)
Query: 52 LLQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMIAHGSNVMSA 111
L+QA+ N D V ALI +K V + D E ++ H AA G A +E++I G+ V +
Sbjct: 12 LVQAIFNGDPDEVRALIFKKEDVNFQ-DNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
Query: 112 DGAGYNALHLAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAGGCLSCSEVLCSFK 171
D LH A + ++ LL+ S V+ D + T LH AAA + C+E L
Sbjct: 71 DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
Query: 172 AHLNPQDRSGATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALMLACEGASPETVE 231
+++N DR+G T L AA H ++ +LLL +GA N D + R A+ A E V+
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190
Query: 232 VLLQGGAQPGITDALGQDAAHYGALAGDKLILHLLQEAAQRPSPPSA 278
+L+ GA+ D H A +G ++ L + + P+A
Sbjct: 191 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNA 237
Score = 90.1 bits (222), Expect = 1e-17
Identities = 72/262 (27%), Positives = 107/262 (40%), Gaps = 40/262 (15%)
Query: 46 GKSDERLLQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMIAHG 105
G L+ +V N V +L+ + V K D G++A H A+ G C++ ++ HG
Sbjct: 651 GNGQTPLMLSVLNGHTDCVYSLLNKGANVDAK-DKWGRTALHRGAVTGHEECVDALLQHG 709
Query: 106 SNVMSADGAGYNALHLAAKYGHPQCLKQLLQASCVVD----VVDSSGWTALHHAAAGGCL 161
+ + D G +HL+A GH L LLQ++ +D D+ G+TALH A G
Sbjct: 710 AKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHE 769
Query: 162 SCSEVLCSFKAH----------------------------------LNPQDRSGATPLII 187
+C E+L + +N D G TPL
Sbjct: 770 TCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHA 829
Query: 188 AAQMCHTDLCRLLLQQGAAANDQDLQGRTALMLACEGASPETVEVLL-QGGAQPGITDAL 246
AA H + +LLL A N D G+T LM+A E TVE+L+ A+ + D
Sbjct: 830 AAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNS 889
Query: 247 GQDAAHYGALAGDKLILHLLQE 268
A H G + L+ E
Sbjct: 890 KNTALHLACSKGHETSALLILE 911
Score = 85.1 bits (209), Expect = 3e-16
Identities = 79/268 (29%), Positives = 119/268 (44%), Gaps = 52/268 (19%)
Query: 68 IARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMIAH----------GSNVMSADG--AG 115
+ R P D +G +A H +A G CL+++ + G++++S A
Sbjct: 491 LLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRAT 550
Query: 116 YNALHLAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAGGCLSCSEVLCSFKAHL- 174
+ LHLAA +GH Q L+ L+Q+ +DV +SSG T L AA G + C +VL + A +
Sbjct: 551 ISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASIL 610
Query: 175 ------------------------------------NPQDRSGATPLIIAAQMCHTDLCR 198
+ QD +G TPL+++ HTD
Sbjct: 611 VKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVY 670
Query: 199 LLLQQGAAANDQDLQGRTALMLACEGASPETVEVLLQGGAQPGITDALGQDAAHYGALAG 258
LL +GA + +D GRTAL E V+ LLQ GA+ + D+ G+ H A G
Sbjct: 671 SLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG 730
Query: 259 DKLIL-HLLQEAAQRPSPPSALTEDDSG 285
+L LLQ AA + P+ T D+ G
Sbjct: 731 HIGVLGALLQSAASMDANPA--TADNHG 756
Score = 81.6 bits (200), Expect = 4e-15
Identities = 58/190 (30%), Positives = 86/190 (45%), Gaps = 6/190 (3%)
Query: 79 DPEGKSAFHLAAMRGAASCLEVMIAHGSNVMSADGAGYNALHLAAKYGHPQCLKQLLQAS 138
D ++ H+AA A C E ++ SNV +D AG ALH AA GH + +K LL
Sbjct: 104 DKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRG 163
Query: 139 CVVDVVDSSGWTALHHAAAGGCLSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLCR 198
++ D A+H AA G + ++L S A + +D+ TPL AA + +
Sbjct: 164 ANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVK 223
Query: 199 LLLQQGAAANDQDLQGRTALMLACEGASPETVEVLLQGGA------QPGITDALGQDAAH 252
LL G N+ + G T L +AC V L+ GA + G T A+
Sbjct: 224 YLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAAST 283
Query: 253 YGALAGDKLI 262
+GAL + L+
Sbjct: 284 HGALCLELLV 293
Score = 78.6 bits (192), Expect = 3e-14
Identities = 57/201 (28%), Positives = 87/201 (43%), Gaps = 1/201 (0%)
Query: 67 LIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMIAHGSNVMSADGAGYNALHLAAKYG 126
L+ +G D + + A H AA G ++++++HG+ V D Y LH AA G
Sbjct: 158 LLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSG 217
Query: 127 HPQCLKQLLQASCVVDVVDSSGWTALHHAAAGGCLSCSEVLCSFKAHLNPQDRSGATPLI 186
+K LL ++ ++ G T LH A G L A +N ++ G TPL
Sbjct: 218 MISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLH 277
Query: 187 IAAQMCHTDLC-RLLLQQGAAANDQDLQGRTALMLACEGASPETVEVLLQGGAQPGITDA 245
AA H LC LL+ GA N + G+T L + + ++Q GA D
Sbjct: 278 FAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDK 337
Query: 246 LGQDAAHYGALAGDKLILHLL 266
G H A G +L+++ L
Sbjct: 338 NGNTPLHIAARYGHELLINTL 358
Score = 77.8 bits (190), Expect = 5e-14
Identities = 82/284 (28%), Positives = 118/284 (41%), Gaps = 58/284 (20%)
Query: 44 DWGKSDE----RLLQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGA-ASCL 98
D+ K D+ L A N + + AL+ G LD G + H AA CL
Sbjct: 430 DFNKKDKFGRSPLHYAAANCNYQCLFALVG-SGASVNDLDERGCTPLHYAATSDTDGKCL 488
Query: 99 EVMIAHGSNVMSADGAGYNALHLAAKYGHPQCLKQLLQASCVVDV-VDSSGW-------- 149
E ++ + +N D GYNA+H +A YGH CL QL+ + +DV +++SG
Sbjct: 489 EYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCL-QLIASETPLDVLMETSGTDMLSDSDN 547
Query: 150 ----TALHHAAAGGCLSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLCRLLLQQGA 205
+ LH AA G EVL L+ ++ SG TPL +AA H + +L+ QGA
Sbjct: 548 RATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGA 607
Query: 206 -------------------------------------AANDQDLQGRTALMLACEGASPE 228
A + QD G+T LML+ +
Sbjct: 608 SILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTD 667
Query: 229 TVEVLLQGGAQPGITDALGQDAAHYGALAG-DKLILHLLQEAAQ 271
V LL GA D G+ A H GA+ G ++ + LLQ A+
Sbjct: 668 CVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAK 711
Score = 75.1 bits (183), Expect = 4e-13
Identities = 56/214 (26%), Positives = 89/214 (41%), Gaps = 3/214 (1%)
Query: 47 KSDERLLQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMIAHGS 106
K D R + V L+ G T D + + H AA G S ++ ++ G
Sbjct: 171 KKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGV 230
Query: 107 NVMSADGAGYNALHLAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAG--GCLSCS 164
++ + G LH+A G + +L+ +V+ + G+T LH AAA G L C
Sbjct: 231 DMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGAL-CL 289
Query: 165 EVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALMLACEG 224
E+L A +N + + G TPL + A + ++Q GA + +D G T L +A
Sbjct: 290 ELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARY 349
Query: 225 ASPETVEVLLQGGAQPGITDALGQDAAHYGALAG 258
+ L+ GA G H AL+G
Sbjct: 350 GHELLINTLITSGADTAKRGIHGMFPLHLAALSG 383
Score = 71.2 bits (173), Expect = 5e-12
Identities = 54/186 (29%), Positives = 80/186 (43%), Gaps = 1/186 (0%)
Query: 82 GKSAFHLAAMRGAASCLEVMIAHGSNVMSADGAGYNALHLAAKYGHPQ-CLKQLLQASCV 140
G + H+A G + +I G+ V + G+ LH AA H CL+ L+
Sbjct: 239 GNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGAD 298
Query: 141 VDVVDSSGWTALHHAAAGGCLSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLCRLL 200
V++ G T LH A G S S+ + A ++ +D++G TPL IAA+ H L L
Sbjct: 299 VNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTL 358
Query: 201 LQQGAAANDQDLQGRTALMLACEGASPETVEVLLQGGAQPGITDALGQDAAHYGALAGDK 260
+ GA + + G L LA + LL G D G+ H A G+
Sbjct: 359 ITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNL 418
Query: 261 LILHLL 266
L+LL
Sbjct: 419 ECLNLL 424
Score = 58.2 bits (139), Expect = 5e-08
Identities = 50/173 (28%), Positives = 86/173 (49%), Gaps = 6/173 (3%)
Query: 55 AVENNDAPRVAALIARKGL-VPTKLDPEGKSAFHLAAMRGAASCLEVMIAHGSNVMSADG 113
AV N++ LI G + D +G++ H AA CL+++++H + V S D
Sbjct: 795 AVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDS 854
Query: 114 AGYNALHLAAKYGHPQCLKQLLQ-ASCVVDVVDSSGWTALHHAAAGGCLSCSEVLC---S 169
G L +AA+ G ++ L+ AS + + D+S TALH A + G + + ++ +
Sbjct: 855 TGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKIT 914
Query: 170 FKAHLNPQDRSGATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALMLAC 222
+ +N + + TPL +AA+ T + + LL +GA+ D G T LAC
Sbjct: 915 DRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP-ALAC 966
Score = 41.6 bits (96), Expect = 0.004
Identities = 34/141 (24%), Positives = 59/141 (41%), Gaps = 4/141 (2%)
Query: 53 LQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMIAHGSNVMSA- 111
L A D L+ +D GK+ +AA G + +E++++ S ++
Sbjct: 827 LHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQ 886
Query: 112 DGAGYNALHLAAKYGHPQCLKQLLQASC---VVDVVDSSGWTALHHAAAGGCLSCSEVLC 168
D + ALHLA GH +L+ +++ +++ T LH AA G + L
Sbjct: 887 DNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELL 946
Query: 169 SFKAHLNPQDRSGATPLIIAA 189
A + D +G TP + A
Sbjct: 947 GKGASVLAVDENGYTPALACA 967
Score = 38.5 bits (88), Expect = 0.037
Identities = 28/102 (27%), Positives = 46/102 (45%), Gaps = 3/102 (2%)
Query: 52 LLQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRG---AASCLEVMIAHGSNV 108
L+ A EN V L++ T D +A HLA +G +A + I + +
Sbjct: 860 LMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLI 919
Query: 109 MSADGAGYNALHLAAKYGHPQCLKQLLQASCVVDVVDSSGWT 150
+ + A LH+AA+ G +++LL V VD +G+T
Sbjct: 920 NATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYT 961
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 111 bits (277), Expect = 4e-24
Identities = 201/847 (23%), Positives = 352/847 (41%), Gaps = 102/847 (12%)
Query: 336 LLQKIRGLEQHKERRQQESPEASSLHILER-----QVQELQQLLVERQEEKESLGREVES 390
LL K + LE+ R QE + S LE+ +V EL LL + Q++ E + +++
Sbjct: 249 LLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKA 308
Query: 391 LQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSAQEHLASLQEQVAV 450
L+ + +LE T L + E L E L +Q+ + + + +A
Sbjct: 309 LRETVEILETNH-------TELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ 361
Query: 451 LTRQNQELMEKVQILENFEKDETQMEVEALAEVIPLALYDSLRAEFDQLRRQHA---EAL 507
+ L I F+ + + + V+ R LR+Q A EA+
Sbjct: 362 GSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRR-----RQAVQDLRQQLAGCQEAV 416
Query: 508 QALRQQETREVPREEGAACGE--SEVAGATATKNGPTHMELNGSVAPETKVNGAETIDEE 565
L+QQ + EEG A + ++ G T G T ++L G V +K + ++
Sbjct: 417 NLLQQQHDQW--EEEGKALRQRLQKLTGERDTLAGQT-VDLQGEVDSLSK---ERELLQK 470
Query: 566 AAGDETMEARTMEAEA-------TGAEATGAEATGAKVTETKPTGAEVREMETTEEEA-N 617
A + + +E EA + G A G K + + VRE E +E
Sbjct: 471 AREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMG 530
Query: 618 METKPTGAQAT-DTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTNM---E 673
+E K + + + T +E+ +E + E+ E+ A A Q+ ++ + N E
Sbjct: 531 LEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTE 590
Query: 674 ATGSRATGMESTGVS-ATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIRGL 732
RA ++ + ++ A ++ G+ + + EA+E+ + L+ L
Sbjct: 591 VADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQV---DL 647
Query: 733 EEALRQRER--EAAAELEAALGKCEAAEAEA-GRLRERVREAEG-----SGASGGGGGDT 784
EA ++RE E LEA L K E A AE LR+ E E S + T
Sbjct: 648 AEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAAT 707
Query: 785 TQLRAALEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQREEARL 844
TQL ++A+ R+ E + + E A L+ E+ A +R + +R+ L
Sbjct: 708 TQLEQLHQEAK----------RQEEVLARAVQEKEA--LVREKAALEVRLQAVERDRQDL 755
Query: 845 -EQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELR 903
EQ + L +E L ++ +QQ + + + E ++ + A E + + L+
Sbjct: 756 AEQLQGLSSAKELLESSLFEAQQQNSV---IEVTKGQLEVQIQTVTQAKEVIQGEVRCLK 812
Query: 904 EASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSVA 963
+ R + Q E G+ A LEQ+ A KE +LR + E+ER S
Sbjct: 813 LELDTERSQAEQERDAAARQLAQAEQEGKTA-LEQQKAAHEKEVNQLREKWEKER--SWH 869
Query: 964 LSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATA 1023
E + + +L+ +LE +L+E ++T E Q QRE ER AE+ L
Sbjct: 870 QQELAKALESLEREKMELEMRLKE-----QQTEMEAIQAQRE-----EERTQAESALCQM 919
Query: 1024 EQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPE 1083
+ L TE ER L+ + K++ + S+++ L++ +K Q L E
Sbjct: 920 Q-----LETEKERV--------SLLETLLQTQKELADASQQLERLRQDMKVQK--LKEQE 964
Query: 1084 VEA-LRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMD--EDVQRILSQIL---Q 1137
L+ Q+++ Q++L+EAAR H +A + +Q +MD + V+ + SQ++
Sbjct: 965 TTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDD 1024
Query: 1138 MQRLQAQ 1144
QRL Q
Sbjct: 1025 SQRLVEQ 1031
Score = 108 bits (269), Expect = 4e-23
Identities = 199/863 (23%), Positives = 348/863 (40%), Gaps = 141/863 (16%)
Query: 329 LRQERGRLLQKIRGLEQ--HKERRQQESPEASSLHILERQVQELQQLLVERQEEKESL-- 384
L Q++ +++ L + KER + A +L LER+ EL+ L E+Q E E++
Sbjct: 844 LEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQA 903
Query: 385 GREVESLQSRLSL----LENERENTSYDVTTLQDEEGELPD----------------LPG 424
RE E Q+ +L LE E+E S T LQ ++ EL D L
Sbjct: 904 QREEERTQAESALCQMQLETEKERVSLLETLLQTQK-ELADASQQLERLRQDMKVQKLKE 962
Query: 425 AEVL---------LSRQLSPSAQEH---LASLQEQVAVLTRQNQELMEKVQILEN--FEK 470
E R+L +A++H LA+LQE+ + L + +L ++V+ L++ +
Sbjct: 963 QETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQ 1022
Query: 471 DETQ--MEVEALAEVIPLALYDSLRAEFDQLRRQHAEALQALRQQETREVPREEGAACGE 528
D++Q +E E ++ Y+ ++ E L R+ A +L ++E R + +E + +
Sbjct: 1023 DDSQRLVEQEVQEKLRETQEYNRIQKE---LEREKASLTLSLMEKEQRLLVLQEADSIRQ 1079
Query: 529 SEVAGAT--------ATKNGPTHMELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAE 580
E++ K MEL + E K A+ + +EA E +EA + +
Sbjct: 1080 QELSALRQDMQEAQGEQKELSAQMEL---LRQEVKEKEADFLAQEAQLLEELEASHITEQ 1136
Query: 581 ATGAEATGAEATGAKVTETKPTGAEVREMETTEEEANMETKPTGAQATDTETTGVEAMGV 640
A EA A++ +R E+ E E +P + + +
Sbjct: 1137 QLRASLWAQEAKAAQLQ------LRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQ 1190
Query: 641 EATKTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRATGMESTGVSATGVENPGVEAT 700
+A + E + G G + P V G +E + A + G T + V
Sbjct: 1191 QALGSVCESRPELS---GGGDSAPSVWG---LEPDQNGARSLFKRGPLLTALSAEAV--- 1241
Query: 701 VPGISAGPILHPGAAEASEKLQVELETRIRGLEEALRQREREAAAELEAALGKCEAAEAE 760
SA LH + + V L +++ LEE L E AE + + + +
Sbjct: 1242 ---ASALHKLHQDLWKTQQTRDV-LRDQVQKLEERLTDTE----AEKSQVHTELQDLQRQ 1293
Query: 761 AGRLRERVREAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRLRELEAASACLDEARA 820
+ +E + EG S L + L + E + SRLR E EA+
Sbjct: 1294 LSQNQEEKSKWEGKQNS---------LESELMELHETMASLQSRLRRAELQRM---EAQG 1341
Query: 821 SRLLAEEEARGLRAELAQREEARLE---QSRELEVLREQLATARAT----GEQQRTAAAE 873
R L + L A++ + A +E Q+ +L E L TAR+ E+ +
Sbjct: 1342 ERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERER 1401
Query: 874 LGRARDAAEARVAELPAACEE---ARQGLAELREASEALRQSVVPASEHRRLQEEALEL- 929
++ E +VA+ A E Q LAE E E LR + + R +Q+ ALEL
Sbjct: 1402 AQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELL 1461
Query: 930 ------RGRAASLEQEVVATGKEAARLRAEL--------ERERVCSVALSEHERIVGTLQ 975
R + L+QE + +E + R+ L ERE+ +V + + +
Sbjct: 1462 SLDLKKRNQEVDLQQEQI---QELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRE 1518
Query: 976 ANVAQLEGQLEELGRRHEKTSAEVFQVQR----------EALFMKSERHAAEAQLATAEQ 1025
LE QL EL ++ + ++ QVQ AL ++ H E Q ++
Sbjct: 1519 TQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQ----QK 1574
Query: 1026 QLRGLRTEAERARQAQSR----AQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALAT 1081
++ L + E R A + +E + + + +I +L L L+E+
Sbjct: 1575 LIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQER-----D 1629
Query: 1082 PEVEALRDQVKDLQQQLQEAARD 1104
EV++ R+Q+++LQ+Q + +D
Sbjct: 1630 QEVKSQREQIEELQRQKEHLTQD 1652
Score = 86.7 bits (213), Expect = 1e-16
Identities = 200/820 (24%), Positives = 335/820 (40%), Gaps = 119/820 (14%)
Query: 321 DAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEE 380
D E+ L +ER LLQK R +E RQQ L +LE++ L+++ VE Q +
Sbjct: 453 DLQGEVDSLSKER-ELLQKAR-----EELRQQ-------LEVLEQEAWRLRRVNVELQLQ 499
Query: 381 KESLGREVESLQSRLSLLENERENTSYDVTTLQDEEGE-LPDLPGAEVLLSRQLSPSAQE 439
+S + E Q L L ERE + L+ ++ E L +L + L L S E
Sbjct: 500 GDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSEL----ITLREALESSHLE 555
Query: 440 HLASLQEQ---VAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIPLALYDSLRAEF 496
QEQ A L R Q + E + EN K E ++ A A + AL ++L +
Sbjct: 556 GELLRQEQTEVTAALARAEQSIAE-LSSSENTLKTEV-ADLRAAAVKLS-ALNEALALDK 612
Query: 497 DQLRRQHAEALQALRQQETREVPREEGA--ACGESEVAGATATKNGPTHMELNGSVAPET 554
L +Q L L ++ R E A A +V A A K E N + E
Sbjct: 613 VGLNQQ----LLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHL--EA 666
Query: 555 KVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETK-PTGAEVREMETTE 613
++ A EEA + + R ++ E E K++E++ A ++E
Sbjct: 667 QLQKA----EEAGAELQADLRDIQEE--------KEEIQKKLSESRHQQEAATTQLEQLH 714
Query: 614 EEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTNME 673
+EA + + + E E +E + +A E + Q A Q + + +E
Sbjct: 715 QEAKRQEEVLARAVQEKEALVREKAALE-VRLQAVERDRQDL---AEQLQGLSSAKELLE 770
Query: 674 ATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIRGLE 733
++ A S V +E + ++ + G L++EL+T E
Sbjct: 771 SSLFEAQQQN----SVIEVTKGQLEVQIQTVTQAKEVIQGEVRC---LKLELDT-----E 818
Query: 734 EALRQREREAAA--------ELEAALGKCEAA-EAEAGRLRERVREAEGSGASGGGGGDT 784
+ ++ER+AAA E + AL + +AA E E +LRE+ +
Sbjct: 819 RSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKER--------SWHQ 870
Query: 785 TQLRAALEQAREDLRDRDSRLR----ELEAASACLDEARAS--------RLLAEEEARGL 832
+L ALE + + + RL+ E+EA A +E R +L E+E L
Sbjct: 871 QELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSL 930
Query: 833 RAELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAAC 892
L Q ++ + S++LE LR+ + + EQ+ T G + + EL A
Sbjct: 931 LETLLQTQKELADASQQLERLRQDMKVQKLK-EQETT-----GILQTQLQEAQRELKEAA 984
Query: 893 EEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAAS-------LEQEV---VA 942
+ R LA L+E S +L Q + LQ++ +L+ + + +EQEV +
Sbjct: 985 RQHRDDLAALQEESSSLLQ------DKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLR 1038
Query: 943 TGKEAARLRAELERERV-CSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQ 1001
+E R++ ELERE+ +++L E E+ + LQ + + +L L + ++ E +
Sbjct: 1039 ETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKE 1098
Query: 1002 VQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITEL 1061
+ + ++ E EA E QL EA + Q RA +AK ++
Sbjct: 1099 LSAQMELLRQEVKEKEADFLAQEAQLLE-ELEASHITEQQLRASLWAQEAKAAQLQLRLR 1157
Query: 1062 SKEVFNLKEALKEQPAALATPEVEALRDQVKDLQQQLQEA 1101
S E A ++QP A + Q+ L LQ+A
Sbjct: 1158 STESQLEALAAEQQPGNQAQAQA-----QLASLYSALQQA 1192
Score = 81.3 bits (199), Expect = 5e-15
Identities = 194/851 (22%), Positives = 336/851 (39%), Gaps = 107/851 (12%)
Query: 331 QERGRLLQ----KIRGLEQH--------KERRQQESPEASSLHILERQVQELQQLLVERQ 378
+ER + LQ +I LE H +ER Q+ + + L+RQ + L Q L R
Sbjct: 1598 EERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRD 1657
Query: 379 EE-----------KESLGREVESL-----QSRLSLLENERE-NTSYDVTTLQDEEGELP- 420
+E ++ R+ + L Q +LSL E RE T + + EEG+ P
Sbjct: 1658 QELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPS 1717
Query: 421 -----DLPGAEVLL--SRQLSPSAQEHLASLQEQVAVLTRQNQELMEKV---QILENFEK 470
L +++L + QEH+ LQE L +Q Q L KV +L + +
Sbjct: 1718 KAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQRE 1777
Query: 471 DETQMEVEALAEVIPLA--LYDSLRAEFDQLRR---QHAEALQALRQQETREVPREE--- 522
E + + L E SL+++ D+ +R Q + L+AL+Q++ + +EE
Sbjct: 1778 QEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVK 1837
Query: 523 ---GAACGESEVAGATATKNG---PTHMELNGSVAPETKVNGAET-IDEEAAGDETMEAR 575
A G E A T + H E + E V G EE GD E+R
Sbjct: 1838 EKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESR 1897
Query: 576 TMEAEATGAEATGAEATGAKVTETKPTGAEVREMETTEEEANMETKPTGAQATDTETTGV 635
E + AE ET+ + + +E + E + A +++++
Sbjct: 1898 EQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELE---ALRAESQSSRH 1954
Query: 636 EAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRATGMESTGVSATGVENP 695
+ A +EA +A+ G+ E + + + +T + A +
Sbjct: 1955 QEEAARARAEALQEALGKAHAALQGK-EQHLLEQAELSRSLEASTATLQASLDACQAHSR 2013
Query: 696 GVEATVPGISAGPI-------------LHPGAAEASEKLQVELETRIRGLEEALRQRERE 742
+E + I G I L A+ E+L+ + E R + LE++L QR +E
Sbjct: 2014 QLEEAL-RIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQE-REQLLEKSLAQRVQE 2071
Query: 743 AAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGDTTQLRAALEQAREDLRDRD 802
+ + LG+ E E E L + VRE + + A + +LR ++ +
Sbjct: 2072 NMIQEKQNLGQ-EREEEEIRGLHQSVRELQLTLAQ--KEQEILELRETQQRNNLEALPHS 2128
Query: 803 SRLRELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQSRELEVLREQLATARA 862
+ +E S LD + E L+A L Q E +E + + L LA +A
Sbjct: 2129 HKTSPMEEQSLKLDSLEPR---LQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKA 2185
Query: 863 TGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRRL 922
+ + A L +A V E + + + L R A E R A+ L
Sbjct: 2186 SVSSLQEVAMFL-------QASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAEL 2238
Query: 923 ---QEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHERIVGTLQANVA 979
E+ ++L G + +E E G E R LE + +VA E +R LQ +
Sbjct: 2239 GSRGEQGVQL-GEVSGVEAEPSPDGMEKQSWRQRLEHLQQ-AVARLEIDR--SRLQRHNV 2294
Query: 980 QLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLR-TEAERAR 1038
QL LE++ R K E + + S+ A+ + +Q RG + ++A+
Sbjct: 2295 QLRSTLEQVERERRKLKREAMRAAQAGSLEISKATAS----SPTQQDGRGQKNSDAKCVA 2350
Query: 1039 QAQS-----RAQEALDKAKEKD--KKITELSKEVFNLKEALKEQPAALA-TPEVEALRDQ 1090
+ Q +AQ L++ +++D + + S+E+ L +L A+A PE L +
Sbjct: 2351 ELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAE 2410
Query: 1091 VKDLQQQLQEA 1101
+ L + L ++
Sbjct: 2411 TRRLDESLTQS 2421
Score = 70.5 bits (171), Expect = 9e-12
Identities = 204/966 (21%), Positives = 366/966 (37%), Gaps = 159/966 (16%)
Query: 320 RDAYEEIVRLRQERGRLLQKIRGLE-QHKERRQQESPEASSLHILERQVQELQQLLVERQ 378
R +++ L++E LLQ L+ Q ++ + Q + S ++E++VQE + E
Sbjct: 985 RQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYN 1044
Query: 379 EEKESLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSAQ 438
++ L RE SL LSL+E E+ + LQ+ + + E+ RQ AQ
Sbjct: 1045 RIQKELEREKASLT--LSLMEKEQR-----LLVLQEADS----IRQQELSALRQDMQEAQ 1093
Query: 439 EHLASLQEQVAVLTRQNQE-----LMEKVQILENFEKD---ETQMEV-----EALAEVIP 485
L Q+ +L ++ +E L ++ Q+LE E E Q+ EA A +
Sbjct: 1094 GEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQ 1153
Query: 486 LAL------YDSLRAEFD-----QLRRQHAEALQALRQQ-----ETREVPREEGAACGES 529
L L ++L AE Q + Q A AL+Q E+R P G
Sbjct: 1154 LRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESR--PELSGGGDSAP 1211
Query: 530 EVAGATATKNGPTHMELNG----SVAPETKVNGAETIDEEA-AGDETMEARTMEAEATGA 584
V G +NG + G +++ E + + ++ +T + + +
Sbjct: 1212 SVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEE 1271
Query: 585 EATGAEATGAKVT--------------------ETKPTGAEVREMETTEEEANMETKPTG 624
T EA ++V E K E ME E A+++++
Sbjct: 1272 RLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRR 1331
Query: 625 AQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRAT---- 680
A+ E G + A + + E V +A+ G + +R+
Sbjct: 1332 AELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLK 1391
Query: 681 --GMESTGVSATGVENPGVEATVPGISAGP---ILHPGAAEASEKLQVELETRIRGLEEA 735
+ES A ++ G G + +L AE E+++ L +I+ LE+
Sbjct: 1392 NEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVET-LRGQIQELEKQ 1450
Query: 736 --------------LRQREREAAAELEAA--LGKCEAA-----------EAEAGRLRERV 768
L++R +E + E L KC + E + RE++
Sbjct: 1451 REMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQI 1510
Query: 769 REAEGSGASGGGGGDTTQLRAA-----LEQAREDLRDRDSRLRELEAASACLDEARASRL 823
RE E + + L +E R ++D +L LE + L+E
Sbjct: 1511 RELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKME 1570
Query: 824 LAEEEARGLRAELAQREEARL----------EQSRELEVLREQLATARATGEQQRTAAAE 873
++ + L QRE R+ E+S+EL+ Q+ + E
Sbjct: 1571 CQQKLIKELEG---QRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQE 1627
Query: 874 LGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHRRLQ-----EEALE 928
+ + ++ EL E Q L E R+ L++ + E +R + EE LE
Sbjct: 1628 RDQEVKSQREQIEELQRQKEHLTQDL-ERRDQELMLQKERIQVLEDQRTRQTKILEEDLE 1686
Query: 929 L-------RGRAASLEQEVVATGKEAARLRAELERERV--CSVALSEHERIVGTLQANVA 979
RGR + +++++ E + ++ +R + + L + E+ V Q ++
Sbjct: 1687 QIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIH 1746
Query: 980 -------QLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRT 1032
QLE QL+ L R+ +TS + Q ++E + ++ + A Q EQ L+
Sbjct: 1747 ELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLD 1806
Query: 1033 EAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQVK 1092
EA+RA + + EAL + +++ + E KE + + EQ L+D +
Sbjct: 1807 EAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKE 1866
Query: 1093 DLQQQLQEAARDHSSVVAL------------YRSHLLYAIQGQMDEDVQ--RILSQILQM 1138
++ +E A + V AL + L A+Q Q E Q + ++ LQ
Sbjct: 1867 QARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQD 1926
Query: 1139 QRLQAQ 1144
LQAQ
Sbjct: 1927 SWLQAQ 1932
Score = 68.2 bits (165), Expect = 4e-11
Identities = 112/487 (22%), Positives = 195/487 (40%), Gaps = 100/487 (20%)
Query: 714 AAEASEKLQVELETRIRGLEEALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEG 773
A E E + L++++ + AL QR++E LEA + + A+ + R++E+ +G
Sbjct: 1790 AREQGELKEQSLQSQLDEAQRALAQRDQE----LEALQQEQQQAQGQEERVKEKADALQG 1845
Query: 774 SGASGGGGGDTTQLRAALEQAREDLRDRDSRLRELEAASACLDEARA---SRLLAEEEAR 830
ALEQA L++R L++ + + L+E A R+ A EE
Sbjct: 1846 ----------------ALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVL 1889
Query: 831 G-LRAELAQREEARL--------------------------------EQSRELEVLREQL 857
G LRAE ++E+A L E+ +ELE LR +
Sbjct: 1890 GDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAES 1949
Query: 858 ATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPAS 917
++R E R A L A A A + E + L ++ L+ S+
Sbjct: 1950 QSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQ 2009
Query: 918 EHRRLQEEAL-----ELRGRAASLEQEV----VATGKEAARLRAELERERVCSVALSEHE 968
H R EEAL E++ + +++V A + LR + ERE++ +L++
Sbjct: 2010 AHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQR- 2068
Query: 969 RIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLR 1028
+Q N+ Q + + LG+ E + E + + LA EQ++
Sbjct: 2069 -----VQENMIQ---EKQNLGQERE---------EEEIRGLHQSVRELQLTLAQKEQEIL 2111
Query: 1029 GLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVEAL- 1087
LR +R +E+ K+ L L+ L+ AAL E +
Sbjct: 2112 ELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEP---RLQRELERLQAALRQTEAREIE 2168
Query: 1088 -RDQVKDLQQQLQEAARDHSSV--VALYRSHLLYAIQGQMDEDVQRILSQI------LQM 1138
R++ +DL L + SS+ VA++ L A + D + QR+ ++ L+
Sbjct: 2169 WREKAQDLALSLAQTKASVSSLQEVAMF----LQASVLERDSEQQRLQDELELTRRALEK 2224
Query: 1139 QRLQAQG 1145
+RL + G
Sbjct: 2225 ERLHSPG 2231
Score = 56.2 bits (134), Expect = 2e-07
Identities = 161/748 (21%), Positives = 279/748 (37%), Gaps = 102/748 (13%)
Query: 324 EEIVRLRQERGRLLQKIRG-LEQHKERRQQESPEASSL-HILERQVQELQQLLVERQEEK 381
E+ V +QE LQ+++ LEQ + ++ E S L E+++ LQQ L E +E+
Sbjct: 1735 EKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQG 1794
Query: 382 E----SLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSA 437
E SL +++ Q L+ + E E + Q +E + + A Q +
Sbjct: 1795 ELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTL 1854
Query: 438 QEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIPLALYDSLRAEFD 497
+E LQ+ R +EL + + V+AL EV+ LRAE
Sbjct: 1855 KERHGELQDHKEQARRLEEELAVEGR------------RVQALEEVL-----GDLRAE-- 1895
Query: 498 QLRRQHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTHMELNGSVAPETKVN 557
R+ +AL AL+QQ C E T+ L S V
Sbjct: 1896 --SREQEKALLALQQQ------------CAEQAQEHEVETR------ALQDSWLQAQAVL 1935
Query: 558 GAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEVREMETTEEEAN 617
+ EA E+ +R E A EA G G E +E E +
Sbjct: 1936 KERDQELEALRAESQSSRHQEEAARARAEALQEALGK--AHAALQGKEQHLLEQAELSRS 1993
Query: 618 METKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQ--AYGVGAGQAEPPVTGTTNMEAT 675
+E QA+ EA + + E + Q Y Q + +
Sbjct: 1994 LEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRH 2053
Query: 676 GSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIRGLEEA 735
+ ++ EN E G G ++ +LQ+ L + +E
Sbjct: 2054 QQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQK---EQEI 2110
Query: 736 LRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGDTTQLRAALEQAR 795
L RE + LEA + + E L+ E +L+ LE+ +
Sbjct: 2111 LELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLE--------------PRLQRELERLQ 2156
Query: 796 EDLRDRDSR----LRELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQSRELE 851
LR ++R + + + L + +AS +E A L+A + +R+ + ELE
Sbjct: 2157 AALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELE 2216
Query: 852 VLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAA-CEEARQGLAE--LREASEA 908
+ R L R T+ AELG +R ++ E+ E + G+ + R+ E
Sbjct: 2217 LTRRALEKER-LHSPGATSTAELG-SRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEH 2274
Query: 909 LRQSVVPAS-EHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEH 967
L+Q+V + RLQ ++LR +E+E R +L+RE + +
Sbjct: 2275 LQQAVARLEIDRSRLQRHNVQLRSTLEQVERE-----------RRKLKREAMRAAQ---- 2319
Query: 968 ERIVGTLQANVAQLEGQLEELGRRHEKTSAE-VFQVQREALFMKSERHAAEAQ------- 1019
G+L+ + A ++ GR + + A+ V ++Q+E + ++++ Q
Sbjct: 2320 ---AGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITR 2376
Query: 1020 LATAEQQLRGLRTEAERARQAQSRAQEA 1047
A ++L GL + A ++A EA
Sbjct: 2377 SAQTSRELAGLHHSLSHSLLAVAQAPEA 2404
Score = 32.3 bits (72), Expect = 2.6
Identities = 70/355 (19%), Positives = 135/355 (38%), Gaps = 93/355 (26%)
Query: 822 RLLAEEEARGLRAELAQREEARLEQSRELEVLREQLATA----RATGEQQRTAAAELGRA 877
+L+ EE+ L+ ++A+ + A + + + +++ AT +A Q R+ EL +
Sbjct: 17 QLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKR 76
Query: 878 RDAA------------EARVAELPAACEEARQGLAELREASEALRQSVVPASE-HRRLQE 924
+A E + EL EE +Q L E + LR + A ++ L+E
Sbjct: 77 LEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALRE 136
Query: 925 EALEL--------------------------------RGRAASLEQEVVATGKEAARLRA 952
+ +L GR SL +EVV + +++
Sbjct: 137 DVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKS 196
Query: 953 ELERERVCSVALSEHERIVGTL--------------------------QANVAQLEGQLE 986
+R+ + A EH R+ G+L A + L + +
Sbjct: 197 ATDRDLMELKA--EHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQ 254
Query: 987 ELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQE 1046
EL + + S E+ Q +KS+ +A+L +L L T++++ + + +
Sbjct: 255 ELEKEAHERSQELIQ-------LKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIK 307
Query: 1047 ALDKAKE-KDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQQQLQE 1100
AL + E + TEL + +L +E E +L+ +KD+ Q + E
Sbjct: 308 ALRETVEILETNHTELMEHEASLSRNAQE--------EKLSLQQVIKDITQVMVE 354
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 109 bits (273), Expect = 1e-23
Identities = 211/913 (23%), Positives = 351/913 (38%), Gaps = 139/913 (15%)
Query: 263 LHLLQEAAQRPSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDA 322
L LL++ + S L ED E SSQ + + K R A+I +DR
Sbjct: 1012 LLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYE--ATIADMEDR-- 1067
Query: 323 YEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKE 382
++E+GR + LE+ K R ES E L+ Q+ E QQ +E +
Sbjct: 1068 -----LRKEEKGR-----QELEKLKRRLDGESSE------LQEQMVEQQQ---RAEELRA 1108
Query: 383 SLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSAQEHLA 442
LGR+ E LQ+ L+ E+E + + +L++ + L + AQE L
Sbjct: 1109 QLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAE---------------AQEDLE 1153
Query: 443 SLQEQVAVLTRQNQELMEKVQIL-----ENFEKDETQMEVEALAEVIPLALYDSLRAEFD 497
S + +Q ++L E+++ L + + Q E+ + E L +L E
Sbjct: 1154 SERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEE-- 1211
Query: 498 QLRRQHAEALQALRQQETREVPREEGAACGE--SEVAGATATKNG--PTHMELNGSVAP- 552
R H A+Q LRQ+ G A GE ++ A K T + L V+
Sbjct: 1212 --TRIHEAAVQELRQRH--------GQALGELAEQLEQARRGKGAWEKTRLALEAEVSEL 1261
Query: 553 ETKVNGAETIDEEAAGDETMEARTMEA-EATGAEATGAEATGAKVTETKPTGAEVREMET 611
+++ +T +E G++ ++ E G G A + + AE+ +
Sbjct: 1262 RAELSSLQTARQE--GEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSG 1319
Query: 612 TEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTN 671
EA +T + + TE +A + +T+A+ A
Sbjct: 1320 ALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLA--------------------- 1358
Query: 672 MEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASE--KLQVELETRI 729
GSR ME+ A G+ E AG L A+ SE + Q E +
Sbjct: 1359 ---LGSRVRAMEA---EAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGAL 1412
Query: 730 RGLEEALRQREREAAAELEAALGKCEAAEA-EAGRLRERVREAEGSGASGGGGGDTTQLR 788
EEA R+ REA A + K E + E GR R L+
Sbjct: 1413 EAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRR---------------------LQ 1451
Query: 789 AALEQAREDLRDRDSRLRELEAASACLD----EARASRLLAEEEARGLRAELAQREEARL 844
L+ A DL + + LE D E +A+ L A EE AE +RE L
Sbjct: 1452 QELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARAL 1511
Query: 845 EQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELRE 904
+R LE +E R L ++D V EL AC A Q +LR
Sbjct: 1512 SLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRA 1571
Query: 905 ASEALRQSVVPASEHR-RLQ--------EEALELRGRAASLEQEVVATGKEAARLRAELE 955
L + A + + RL+ + +L+GR + E+ K+ E +
Sbjct: 1572 QVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERD 1631
Query: 956 RER-VCSVALSEHERIVGTLQANVAQL--EGQ-LEELGRRHEKTSAEVFQVQREALFMKS 1011
ER ++A++ +++ G L+ AQ+ GQ EE ++ K A++ ++ RE ++
Sbjct: 1632 EERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRT 1691
Query: 1012 ERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEA 1071
R +Q +E++L+GL E R ++ + + A +A++ E++ EV N
Sbjct: 1692 SREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDR---DEMADEVAN---- 1744
Query: 1072 LKEQPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDVQRI 1131
A E L ++ L+++L+E + + YR LL + +R
Sbjct: 1745 -GNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERS 1803
Query: 1132 LSQILQMQRLQAQ 1144
S + R Q +
Sbjct: 1804 FSAKAESGRQQLE 1816
Score = 99.4 bits (246), Expect = 2e-20
Identities = 204/919 (22%), Positives = 355/919 (38%), Gaps = 169/919 (18%)
Query: 331 QERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEK--------- 381
Q R + LQK++ L+Q R +V ELQ + + +EE+
Sbjct: 880 QARAQELQKVQELQQQSAR----------------EVGELQGRVAQLEEERARLAEQLRA 923
Query: 382 ---------ESLGR------EVESLQSRLSLLENERENTSYDVTT--------LQDEEGE 418
E+ GR E+E + S L E E S + T +Q+ E
Sbjct: 924 EAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAH 983
Query: 419 LPDLPGAEVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVE 478
L GA L + + + + +E + +L QN +L ++ ++LE+ + + E
Sbjct: 984 LEAEEGARQKLQLE-KVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAE 1042
Query: 479 ALAEVIPL----ALYDSLRAEFDQLRRQHAEALQAL--------------------RQQE 514
+V L Y++ A+ + R+ + Q L +QQ
Sbjct: 1043 EEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQR 1102
Query: 515 TREVPREEGAACGESEVAGATATKNGPTHMELNGSV--APETKVNGAETIDEEAAG---- 568
E+ + G E + A A A G +L S+ A E ++ E
Sbjct: 1103 AEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKA 1162
Query: 569 -------DETMEARTMEAEATGAEATGA----------EATGAKVT---ETKPTGAEVRE 608
E +EA E E T ++T A E T K T ET+ A V+E
Sbjct: 1163 EKQRRDLGEELEALRGELEDT-LDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1221
Query: 609 METTEEEA------NMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQA 662
+ +A +E G A + +EA E ++ +AE + +Q G+
Sbjct: 1222 LRQRHGQALGELAEQLEQARRGKGAWEKTRLALEA---EVSELRAELSSLQT-ARQEGEQ 1277
Query: 663 EPPVTGTTNMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQ 722
E G G + +A ++ +A + +S GA +E
Sbjct: 1278 RRRRLELQLQEVQGRAGDGERARAEAAEKLQR--AQAELENVS-------GALNEAESKT 1328
Query: 723 VELETRIRGLEEALRQREREAAAELEAAL---GKCEAAEAEAGRLRERVREAEGSGASGG 779
+ L + E L + E A L + A EAEA LRE++ E
Sbjct: 1329 IRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE-------- 1380
Query: 780 GGGDTTQLRAALEQAREDLRDRDSRL----RELEAASACLDEARASRLLAEEEARGLRAE 835
AA E+A +L+ ++L R E + L+ +R A EA L
Sbjct: 1381 --------AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQR 1432
Query: 836 LAQREEA--RLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPA--- 890
LA++ E RLE+ R L+++L A EQQR + L + + + +AE A
Sbjct: 1433 LAEKTETVDRLERGRRR--LQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVL 1490
Query: 891 -ACEEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAAR 949
A EE + AE RE EA S+ A E + E LE + RA E E + + K+
Sbjct: 1491 RAVEERERAEAEGRE-REARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVG 1549
Query: 950 LRAELERERVCSVALSEHERIVGTLQANVAQLEGQL--EELGRRHEKTSAEVFQVQREAL 1007
++ E ER C VA E+ L+A V +LE +L E + + + + + Q E
Sbjct: 1550 -KSVHELERACRVA----EQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHER- 1603
Query: 1008 FMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFN 1067
++ A E + +QLR E + R+ ++ A A K+ + ++ EL ++ +
Sbjct: 1604 DLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAA---RKKLEGELEELKAQMAS 1660
Query: 1068 LKEALKEQPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDED 1127
+ +E A ++ ++ Q+K+L ++++E + + R ++G ++ +
Sbjct: 1661 AGQGKEE-----AVKQLRKMQAQMKELWREVEETRTSREEIFSQNRES-EKRLKG-LEAE 1713
Query: 1128 VQRILSQILQMQRLQAQGR 1146
V R+ ++ R + Q +
Sbjct: 1714 VLRLQEELAASDRARRQAQ 1732
Score = 95.5 bits (236), Expect = 3e-19
Identities = 188/839 (22%), Positives = 308/839 (36%), Gaps = 113/839 (13%)
Query: 320 RDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPE-----ASSLHILERQVQELQ--- 371
RD EE+ LR E L ++ + +R+QE E I E VQEL+
Sbjct: 1167 RDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRH 1226
Query: 372 -QLLVERQEEKESLGREVESLQSRLSLLENERENTSYDVTTLQD--EEGELPDLPGAEVL 428
Q L E E+ E R + + LE E ++++LQ +EGE
Sbjct: 1227 GQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGE---------- 1276
Query: 429 LSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIPLAL 488
Q + L +Q + R E EK+Q Q E+E ++ + A
Sbjct: 1277 ---QRRRRLELQLQEVQGRAGDGERARAEAAEKLQ--------RAQAELENVSGALNEAE 1325
Query: 489 YDSLR--AEFDQLRRQHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTHMEL 546
++R E Q +A + L+++ ++ E+E AG
Sbjct: 1326 SKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGL------------ 1373
Query: 547 NGSVAPETKVNGAETIDEEAAGDET--MEARTMEAEATGAEATGAEATGAKVTETKPTGA 604
E ++EEAA E E +T +A+ + E GA G
Sbjct: 1374 ------------REQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGA-----LEAGE 1416
Query: 605 EVREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEP 664
E R E EA T A TET G + + ++A M Q
Sbjct: 1417 EARRRAAREAEA-----LTQRLAEKTETVDRLERGRRRLQQELDDATMD-----LEQQRQ 1466
Query: 665 PVTGTTNMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVE 724
V+ + + E V E EA A + A E ++ + E
Sbjct: 1467 LVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREE 1526
Query: 725 LETRIRGLE---EALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEG--SGASGG 779
LE + R L EAL + + + C AE A LR +V E E + A
Sbjct: 1527 LERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDA 1586
Query: 780 GGGDTTQLRAALEQAREDLRDRDSR--------LRELEAASACLDEARASRLLA------ 825
++A Q DL+ RD ++L A DE R R LA
Sbjct: 1587 KLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKK 1646
Query: 826 -EEEARGLRAELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEAR 884
E E L+A++A + + E ++L ++ Q+ E+ RT+ E+ +E R
Sbjct: 1647 LEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKR 1706
Query: 885 VAELPAACEEARQGLAELREASEALRQSVVPASEH--------RRLQEEALELRGRAASL 936
+ L A ++ LA A +Q ++ + EE +L GR L
Sbjct: 1707 LKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQL 1766
Query: 937 EQEVVATGKEAA----RLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEEL-GRR 991
E+E+ + R R L + + LS ++ QLE Q++EL GR
Sbjct: 1767 EEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1826
Query: 992 HEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKA 1051
E+ + + + ++S+ AE QL EQ+ R + R+A+ R +E + +
Sbjct: 1827 GEEDAGARARHKMTIAALESKLAQAEEQL---EQETRERILSGKLVRRAEKRLKEVVLQV 1883
Query: 1052 KEKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQV--KDLQQQLQEAARDHSSV 1108
+E+ + +L ++ +K+ L E EA R Q + LQ++L++ S+
Sbjct: 1884 EEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESM 1942
Score = 79.7 bits (195), Expect = 1e-14
Identities = 188/829 (22%), Positives = 316/829 (38%), Gaps = 97/829 (11%)
Query: 294 SSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVR-LRQERGRLLQKIRGLEQHKERRQQ 352
S++ +Q KR+ + ++ +E V+ LRQ G+ L ++ EQ ++ R+
Sbjct: 1186 STNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELA--EQLEQARRG 1243
Query: 353 ESPEASSLHILERQVQELQQLLV-------ERQEEKESLGREVESLQSRLSLLENERENT 405
+ + LE +V EL+ L E ++ + L +++ +Q R E R
Sbjct: 1244 KGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEA 1303
Query: 406 SYDVTTLQDE----EGELPDLPGAEVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEK 461
+ + Q E G L + + LS++LS S + L QE + TR L +
Sbjct: 1304 AEKLQRAQAELENVSGALNEAESKTIRLSKELS-STEAQLHDAQELLQEETRAKLALGSR 1362
Query: 462 VQILENFEKD-ETQMEVEALAEVIPLALYDSLRAEFDQLRRQHAEALQAL------RQQE 514
V+ +E Q+E EA A + +A+ + RR+ E AL R++
Sbjct: 1363 VRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRA 1422
Query: 515 TREVPREEGAACGESEVAGATATKNGPTHMELNGSVAP--------ETKVNGAETIDEEA 566
RE ++E EL+ + T D+
Sbjct: 1423 AREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLL 1482
Query: 567 AGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEVREMETTEEEANMETKPTGAQ 626
A ++ R +E E AEA G E ++ T+ E E E + A
Sbjct: 1483 AEEKAAVLRAVE-ERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEAL 1541
Query: 627 ATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRATGMESTG 686
+ + G +E AE+A A VT + E T + +
Sbjct: 1542 LSSKDDVGKSVHELERACRVAEQA--------ANDLRAQVTELED-ELTAAEDAKLR--- 1589
Query: 687 VSATGVENPGVEATVPGISAGPILH-PGAAEASEKLQVELETRIRGLE----EALRQRER 741
+E TV + G EA E+ + +L ++R E E +QR
Sbjct: 1590 ----------LEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTL 1639
Query: 742 EAAA--ELEAALGKCEAAEAEAGRLRER-VREAEGSGASGGG-GGDTTQLRAALEQARED 797
AA +LE L + +A A AG+ +E V++ A + + R + E+
Sbjct: 1640 AVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQ 1699
Query: 798 LRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQR-------EEARLEQSREL 850
R+ + RL+ LEA L E A+ A +A+ R E+A + A LE+ R+L
Sbjct: 1700 NRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQL 1759
Query: 851 E----VLREQLATARATGE-----------QQRTAAAELGRARD---AAEARVAELPAAC 892
E L E+L ++ E Q + EL R AE+ +L
Sbjct: 1760 EGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQI 1819
Query: 893 EEARQGLAELREASEALRQSVVPASEHRRLQ-EEALELRGRAASLEQEVVATGKEAAR-- 949
+E R L E + A + + A E + Q EE LE R L ++V ++ +
Sbjct: 1820 QELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEV 1879
Query: 950 -LRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALF 1008
L+ E ER RV + E+ G L+ V QL+ QLEE + A ++QRE
Sbjct: 1880 VLQVEEER-RVADQLRDQLEK--GNLR--VKQLKRQLEEAEEEASRAQAGRRRLQRELED 1934
Query: 1009 MKSERHAAEAQLATAEQQL-RGLRTEAERARQAQSRAQEALDKAKEKDK 1056
+ + ++ T +L RG T R + R +E + +E ++
Sbjct: 1935 VTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEE 1983
Score = 57.4 bits (137), Expect = 8e-08
Identities = 78/297 (26%), Positives = 132/297 (44%), Gaps = 49/297 (16%)
Query: 844 LEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAE-L 902
L+ +R+ EVL+ + + E Q+ +A E+G + RVA+L EE R LAE L
Sbjct: 870 LQVTRQDEVLQARAQELQKVQELQQQSAREVGE----LQGRVAQL----EEERARLAEQL 921
Query: 903 REASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSV 962
R +E L EA E RGR A+ +QE+ E L A + E CS
Sbjct: 922 RAEAE--------------LCAEAEETRGRLAARKQELELVVSE---LEARVGEEEECSR 964
Query: 963 ALSEHERIVGTLQANVAQLEGQLE-ELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLA 1021
+ ++ LQ ++ +LE LE E G R ++Q E + +++ E L
Sbjct: 965 QMQTEKK---RLQQHIQELEAHLEAEEGARQ--------KLQLEKVTTEAKMKKFEEDLL 1013
Query: 1022 TAEQQLRGLRTE----AERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPA 1077
E Q L E +R + S+A E +K K +K + + ++++ L+++
Sbjct: 1014 LLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEK 1073
Query: 1078 ALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDVQRILSQ 1134
E+E L+ ++ +LQE V R+ L A G+ +E++Q L++
Sbjct: 1074 --GRQELEKLKRRLDGESSELQE-----QMVEQQQRAEELRAQLGRKEEELQAALAR 1123
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 109 bits (273), Expect = 1e-23
Identities = 211/913 (23%), Positives = 351/913 (38%), Gaps = 139/913 (15%)
Query: 263 LHLLQEAAQRPSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDA 322
L LL++ + S L ED E SSQ + + K R A+I +DR
Sbjct: 1004 LLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYE--ATIADMEDR-- 1059
Query: 323 YEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKE 382
++E+GR + LE+ K R ES E L+ Q+ E QQ +E +
Sbjct: 1060 -----LRKEEKGR-----QELEKLKRRLDGESSE------LQEQMVEQQQ---RAEELRA 1100
Query: 383 SLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSAQEHLA 442
LGR+ E LQ+ L+ E+E + + +L++ + L + AQE L
Sbjct: 1101 QLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAE---------------AQEDLE 1145
Query: 443 SLQEQVAVLTRQNQELMEKVQIL-----ENFEKDETQMEVEALAEVIPLALYDSLRAEFD 497
S + +Q ++L E+++ L + + Q E+ + E L +L E
Sbjct: 1146 SERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEE-- 1203
Query: 498 QLRRQHAEALQALRQQETREVPREEGAACGE--SEVAGATATKNG--PTHMELNGSVAP- 552
R H A+Q LRQ+ G A GE ++ A K T + L V+
Sbjct: 1204 --TRIHEAAVQELRQRH--------GQALGELAEQLEQARRGKGAWEKTRLALEAEVSEL 1253
Query: 553 ETKVNGAETIDEEAAGDETMEARTMEA-EATGAEATGAEATGAKVTETKPTGAEVREMET 611
+++ +T +E G++ ++ E G G A + + AE+ +
Sbjct: 1254 RAELSSLQTARQE--GEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSG 1311
Query: 612 TEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTN 671
EA +T + + TE +A + +T+A+ A
Sbjct: 1312 ALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLA--------------------- 1350
Query: 672 MEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASE--KLQVELETRI 729
GSR ME+ A G+ E AG L A+ SE + Q E +
Sbjct: 1351 ---LGSRVRAMEA---EAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGAL 1404
Query: 730 RGLEEALRQREREAAAELEAALGKCEAAEA-EAGRLRERVREAEGSGASGGGGGDTTQLR 788
EEA R+ REA A + K E + E GR R L+
Sbjct: 1405 EAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRR---------------------LQ 1443
Query: 789 AALEQAREDLRDRDSRLRELEAASACLD----EARASRLLAEEEARGLRAELAQREEARL 844
L+ A DL + + LE D E +A+ L A EE AE +RE L
Sbjct: 1444 QELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARAL 1503
Query: 845 EQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELRE 904
+R LE +E R L ++D V EL AC A Q +LR
Sbjct: 1504 SLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRA 1563
Query: 905 ASEALRQSVVPASEHR-RLQ--------EEALELRGRAASLEQEVVATGKEAARLRAELE 955
L + A + + RL+ + +L+GR + E+ K+ E +
Sbjct: 1564 QVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERD 1623
Query: 956 RER-VCSVALSEHERIVGTLQANVAQL--EGQ-LEELGRRHEKTSAEVFQVQREALFMKS 1011
ER ++A++ +++ G L+ AQ+ GQ EE ++ K A++ ++ RE ++
Sbjct: 1624 EERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRT 1683
Query: 1012 ERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEA 1071
R +Q +E++L+GL E R ++ + + A +A++ E++ EV N
Sbjct: 1684 SREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDR---DEMADEVAN---- 1736
Query: 1072 LKEQPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDVQRI 1131
A E L ++ L+++L+E + + YR LL + +R
Sbjct: 1737 -GNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERS 1795
Query: 1132 LSQILQMQRLQAQ 1144
S + R Q +
Sbjct: 1796 FSAKAESGRQQLE 1808
Score = 99.4 bits (246), Expect = 2e-20
Identities = 204/919 (22%), Positives = 355/919 (38%), Gaps = 169/919 (18%)
Query: 331 QERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEK--------- 381
Q R + LQK++ L+Q R +V ELQ + + +EE+
Sbjct: 872 QARAQELQKVQELQQQSAR----------------EVGELQGRVAQLEEERARLAEQLRA 915
Query: 382 ---------ESLGR------EVESLQSRLSLLENERENTSYDVTT--------LQDEEGE 418
E+ GR E+E + S L E E S + T +Q+ E
Sbjct: 916 EAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAH 975
Query: 419 LPDLPGAEVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVE 478
L GA L + + + + +E + +L QN +L ++ ++LE+ + + E
Sbjct: 976 LEAEEGARQKLQLE-KVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAE 1034
Query: 479 ALAEVIPL----ALYDSLRAEFDQLRRQHAEALQAL--------------------RQQE 514
+V L Y++ A+ + R+ + Q L +QQ
Sbjct: 1035 EEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQR 1094
Query: 515 TREVPREEGAACGESEVAGATATKNGPTHMELNGSV--APETKVNGAETIDEEAAG---- 568
E+ + G E + A A A G +L S+ A E ++ E
Sbjct: 1095 AEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKA 1154
Query: 569 -------DETMEARTMEAEATGAEATGA----------EATGAKVT---ETKPTGAEVRE 608
E +EA E E T ++T A E T K T ET+ A V+E
Sbjct: 1155 EKQRRDLGEELEALRGELEDT-LDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1213
Query: 609 METTEEEA------NMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQA 662
+ +A +E G A + +EA E ++ +AE + +Q G+
Sbjct: 1214 LRQRHGQALGELAEQLEQARRGKGAWEKTRLALEA---EVSELRAELSSLQT-ARQEGEQ 1269
Query: 663 EPPVTGTTNMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQ 722
E G G + +A ++ +A + +S GA +E
Sbjct: 1270 RRRRLELQLQEVQGRAGDGERARAEAAEKLQR--AQAELENVS-------GALNEAESKT 1320
Query: 723 VELETRIRGLEEALRQREREAAAELEAAL---GKCEAAEAEAGRLRERVREAEGSGASGG 779
+ L + E L + E A L + A EAEA LRE++ E
Sbjct: 1321 IRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE-------- 1372
Query: 780 GGGDTTQLRAALEQAREDLRDRDSRL----RELEAASACLDEARASRLLAEEEARGLRAE 835
AA E+A +L+ ++L R E + L+ +R A EA L
Sbjct: 1373 --------AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQR 1424
Query: 836 LAQREEA--RLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPA--- 890
LA++ E RLE+ R L+++L A EQQR + L + + + +AE A
Sbjct: 1425 LAEKTETVDRLERGRRR--LQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVL 1482
Query: 891 -ACEEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAAR 949
A EE + AE RE EA S+ A E + E LE + RA E E + + K+
Sbjct: 1483 RAVEERERAEAEGRE-REARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVG 1541
Query: 950 LRAELERERVCSVALSEHERIVGTLQANVAQLEGQL--EELGRRHEKTSAEVFQVQREAL 1007
++ E ER C VA E+ L+A V +LE +L E + + + + + Q E
Sbjct: 1542 -KSVHELERACRVA----EQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHER- 1595
Query: 1008 FMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFN 1067
++ A E + +QLR E + R+ ++ A A K+ + ++ EL ++ +
Sbjct: 1596 DLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAA---RKKLEGELEELKAQMAS 1652
Query: 1068 LKEALKEQPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDED 1127
+ +E A ++ ++ Q+K+L ++++E + + R ++G ++ +
Sbjct: 1653 AGQGKEE-----AVKQLRKMQAQMKELWREVEETRTSREEIFSQNRES-EKRLKG-LEAE 1705
Query: 1128 VQRILSQILQMQRLQAQGR 1146
V R+ ++ R + Q +
Sbjct: 1706 VLRLQEELAASDRARRQAQ 1724
Score = 95.5 bits (236), Expect = 3e-19
Identities = 188/839 (22%), Positives = 308/839 (36%), Gaps = 113/839 (13%)
Query: 320 RDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPE-----ASSLHILERQVQELQ--- 371
RD EE+ LR E L ++ + +R+QE E I E VQEL+
Sbjct: 1159 RDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRH 1218
Query: 372 -QLLVERQEEKESLGREVESLQSRLSLLENERENTSYDVTTLQD--EEGELPDLPGAEVL 428
Q L E E+ E R + + LE E ++++LQ +EGE
Sbjct: 1219 GQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGE---------- 1268
Query: 429 LSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIPLAL 488
Q + L +Q + R E EK+Q Q E+E ++ + A
Sbjct: 1269 ---QRRRRLELQLQEVQGRAGDGERARAEAAEKLQ--------RAQAELENVSGALNEAE 1317
Query: 489 YDSLR--AEFDQLRRQHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTHMEL 546
++R E Q +A + L+++ ++ E+E AG
Sbjct: 1318 SKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGL------------ 1365
Query: 547 NGSVAPETKVNGAETIDEEAAGDET--MEARTMEAEATGAEATGAEATGAKVTETKPTGA 604
E ++EEAA E E +T +A+ + E GA G
Sbjct: 1366 ------------REQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGA-----LEAGE 1408
Query: 605 EVREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEP 664
E R E EA T A TET G + + ++A M Q
Sbjct: 1409 EARRRAAREAEA-----LTQRLAEKTETVDRLERGRRRLQQELDDATMD-----LEQQRQ 1458
Query: 665 PVTGTTNMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVE 724
V+ + + E V E EA A + A E ++ + E
Sbjct: 1459 LVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREE 1518
Query: 725 LETRIRGLE---EALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEG--SGASGG 779
LE + R L EAL + + + C AE A LR +V E E + A
Sbjct: 1519 LERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDA 1578
Query: 780 GGGDTTQLRAALEQAREDLRDRDSR--------LRELEAASACLDEARASRLLA------ 825
++A Q DL+ RD ++L A DE R R LA
Sbjct: 1579 KLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKK 1638
Query: 826 -EEEARGLRAELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEAR 884
E E L+A++A + + E ++L ++ Q+ E+ RT+ E+ +E R
Sbjct: 1639 LEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKR 1698
Query: 885 VAELPAACEEARQGLAELREASEALRQSVVPASEH--------RRLQEEALELRGRAASL 936
+ L A ++ LA A +Q ++ + EE +L GR L
Sbjct: 1699 LKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQL 1758
Query: 937 EQEVVATGKEAA----RLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEEL-GRR 991
E+E+ + R R L + + LS ++ QLE Q++EL GR
Sbjct: 1759 EEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1818
Query: 992 HEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKA 1051
E+ + + + ++S+ AE QL EQ+ R + R+A+ R +E + +
Sbjct: 1819 GEEDAGARARHKMTIAALESKLAQAEEQL---EQETRERILSGKLVRRAEKRLKEVVLQV 1875
Query: 1052 KEKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQV--KDLQQQLQEAARDHSSV 1108
+E+ + +L ++ +K+ L E EA R Q + LQ++L++ S+
Sbjct: 1876 EEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESM 1934
Score = 79.7 bits (195), Expect = 1e-14
Identities = 188/829 (22%), Positives = 316/829 (38%), Gaps = 97/829 (11%)
Query: 294 SSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVR-LRQERGRLLQKIRGLEQHKERRQQ 352
S++ +Q KR+ + ++ +E V+ LRQ G+ L ++ EQ ++ R+
Sbjct: 1178 STNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELA--EQLEQARRG 1235
Query: 353 ESPEASSLHILERQVQELQQLLV-------ERQEEKESLGREVESLQSRLSLLENERENT 405
+ + LE +V EL+ L E ++ + L +++ +Q R E R
Sbjct: 1236 KGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEA 1295
Query: 406 SYDVTTLQDE----EGELPDLPGAEVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEK 461
+ + Q E G L + + LS++LS S + L QE + TR L +
Sbjct: 1296 AEKLQRAQAELENVSGALNEAESKTIRLSKELS-STEAQLHDAQELLQEETRAKLALGSR 1354
Query: 462 VQILENFEKD-ETQMEVEALAEVIPLALYDSLRAEFDQLRRQHAEALQAL------RQQE 514
V+ +E Q+E EA A + +A+ + RR+ E AL R++
Sbjct: 1355 VRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRA 1414
Query: 515 TREVPREEGAACGESEVAGATATKNGPTHMELNGSVAP--------ETKVNGAETIDEEA 566
RE ++E EL+ + T D+
Sbjct: 1415 AREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLL 1474
Query: 567 AGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEVREMETTEEEANMETKPTGAQ 626
A ++ R +E E AEA G E ++ T+ E E E + A
Sbjct: 1475 AEEKAAVLRAVE-ERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEAL 1533
Query: 627 ATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRATGMESTG 686
+ + G +E AE+A A VT + E T + +
Sbjct: 1534 LSSKDDVGKSVHELERACRVAEQA--------ANDLRAQVTELED-ELTAAEDAKLR--- 1581
Query: 687 VSATGVENPGVEATVPGISAGPILH-PGAAEASEKLQVELETRIRGLE----EALRQRER 741
+E TV + G EA E+ + +L ++R E E +QR
Sbjct: 1582 ----------LEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTL 1631
Query: 742 EAAA--ELEAALGKCEAAEAEAGRLRER-VREAEGSGASGGG-GGDTTQLRAALEQARED 797
AA +LE L + +A A AG+ +E V++ A + + R + E+
Sbjct: 1632 AVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQ 1691
Query: 798 LRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQR-------EEARLEQSREL 850
R+ + RL+ LEA L E A+ A +A+ R E+A + A LE+ R+L
Sbjct: 1692 NRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQL 1751
Query: 851 E----VLREQLATARATGE-----------QQRTAAAELGRARD---AAEARVAELPAAC 892
E L E+L ++ E Q + EL R AE+ +L
Sbjct: 1752 EGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQI 1811
Query: 893 EEARQGLAELREASEALRQSVVPASEHRRLQ-EEALELRGRAASLEQEVVATGKEAAR-- 949
+E R L E + A + + A E + Q EE LE R L ++V ++ +
Sbjct: 1812 QELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEV 1871
Query: 950 -LRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALF 1008
L+ E ER RV + E+ G L+ V QL+ QLEE + A ++QRE
Sbjct: 1872 VLQVEEER-RVADQLRDQLEK--GNLR--VKQLKRQLEEAEEEASRAQAGRRRLQRELED 1926
Query: 1009 MKSERHAAEAQLATAEQQL-RGLRTEAERARQAQSRAQEALDKAKEKDK 1056
+ + ++ T +L RG T R + R +E + +E ++
Sbjct: 1927 VTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEE 1975
Score = 57.4 bits (137), Expect = 8e-08
Identities = 78/297 (26%), Positives = 132/297 (44%), Gaps = 49/297 (16%)
Query: 844 LEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAE-L 902
L+ +R+ EVL+ + + E Q+ +A E+G + RVA+L EE R LAE L
Sbjct: 862 LQVTRQDEVLQARAQELQKVQELQQQSAREVGE----LQGRVAQL----EEERARLAEQL 913
Query: 903 REASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSV 962
R +E L EA E RGR A+ +QE+ E L A + E CS
Sbjct: 914 RAEAE--------------LCAEAEETRGRLAARKQELELVVSE---LEARVGEEEECSR 956
Query: 963 ALSEHERIVGTLQANVAQLEGQLE-ELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLA 1021
+ ++ LQ ++ +LE LE E G R ++Q E + +++ E L
Sbjct: 957 QMQTEKK---RLQQHIQELEAHLEAEEGARQ--------KLQLEKVTTEAKMKKFEEDLL 1005
Query: 1022 TAEQQLRGLRTE----AERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPA 1077
E Q L E +R + S+A E +K K +K + + ++++ L+++
Sbjct: 1006 LLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEK 1065
Query: 1078 ALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDVQRILSQ 1134
E+E L+ ++ +LQE V R+ L A G+ +E++Q L++
Sbjct: 1066 --GRQELEKLKRRLDGESSELQE-----QMVEQQQRAEELRAQLGRKEEELQAALAR 1115
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 109 bits (273), Expect = 1e-23
Identities = 211/913 (23%), Positives = 351/913 (38%), Gaps = 139/913 (15%)
Query: 263 LHLLQEAAQRPSPPSALTEDDSGEASSQNSMSSHGKQGAPKKRKAPPPPASIPMPDDRDA 322
L LL++ + S L ED E SSQ + + K R A+I +DR
Sbjct: 1045 LLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYE--ATIADMEDR-- 1100
Query: 323 YEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKE 382
++E+GR + LE+ K R ES E L+ Q+ E QQ +E +
Sbjct: 1101 -----LRKEEKGR-----QELEKLKRRLDGESSE------LQEQMVEQQQ---RAEELRA 1141
Query: 383 SLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSAQEHLA 442
LGR+ E LQ+ L+ E+E + + +L++ + L + AQE L
Sbjct: 1142 QLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAE---------------AQEDLE 1186
Query: 443 SLQEQVAVLTRQNQELMEKVQIL-----ENFEKDETQMEVEALAEVIPLALYDSLRAEFD 497
S + +Q ++L E+++ L + + Q E+ + E L +L E
Sbjct: 1187 SERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEE-- 1244
Query: 498 QLRRQHAEALQALRQQETREVPREEGAACGE--SEVAGATATKNG--PTHMELNGSVAP- 552
R H A+Q LRQ+ G A GE ++ A K T + L V+
Sbjct: 1245 --TRIHEAAVQELRQRH--------GQALGELAEQLEQARRGKGAWEKTRLALEAEVSEL 1294
Query: 553 ETKVNGAETIDEEAAGDETMEARTMEA-EATGAEATGAEATGAKVTETKPTGAEVREMET 611
+++ +T +E G++ ++ E G G A + + AE+ +
Sbjct: 1295 RAELSSLQTARQE--GEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSG 1352
Query: 612 TEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTN 671
EA +T + + TE +A + +T+A+ A
Sbjct: 1353 ALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLA--------------------- 1391
Query: 672 MEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASE--KLQVELETRI 729
GSR ME+ A G+ E AG L A+ SE + Q E +
Sbjct: 1392 ---LGSRVRAMEA---EAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGAL 1445
Query: 730 RGLEEALRQREREAAAELEAALGKCEAAEA-EAGRLRERVREAEGSGASGGGGGDTTQLR 788
EEA R+ REA A + K E + E GR R L+
Sbjct: 1446 EAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRR---------------------LQ 1484
Query: 789 AALEQAREDLRDRDSRLRELEAASACLD----EARASRLLAEEEARGLRAELAQREEARL 844
L+ A DL + + LE D E +A+ L A EE AE +RE L
Sbjct: 1485 QELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARAL 1544
Query: 845 EQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELRE 904
+R LE +E R L ++D V EL AC A Q +LR
Sbjct: 1545 SLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRA 1604
Query: 905 ASEALRQSVVPASEHR-RLQ--------EEALELRGRAASLEQEVVATGKEAARLRAELE 955
L + A + + RL+ + +L+GR + E+ K+ E +
Sbjct: 1605 QVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERD 1664
Query: 956 RER-VCSVALSEHERIVGTLQANVAQL--EGQ-LEELGRRHEKTSAEVFQVQREALFMKS 1011
ER ++A++ +++ G L+ AQ+ GQ EE ++ K A++ ++ RE ++
Sbjct: 1665 EERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRT 1724
Query: 1012 ERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEA 1071
R +Q +E++L+GL E R ++ + + A +A++ E++ EV N
Sbjct: 1725 SREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDR---DEMADEVAN---- 1777
Query: 1072 LKEQPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDVQRI 1131
A E L ++ L+++L+E + + YR LL + +R
Sbjct: 1778 -GNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERS 1836
Query: 1132 LSQILQMQRLQAQ 1144
S + R Q +
Sbjct: 1837 FSAKAESGRQQLE 1849
Score = 99.4 bits (246), Expect = 2e-20
Identities = 204/919 (22%), Positives = 355/919 (38%), Gaps = 169/919 (18%)
Query: 331 QERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEK--------- 381
Q R + LQK++ L+Q R +V ELQ + + +EE+
Sbjct: 913 QARAQELQKVQELQQQSAR----------------EVGELQGRVAQLEEERARLAEQLRA 956
Query: 382 ---------ESLGR------EVESLQSRLSLLENERENTSYDVTT--------LQDEEGE 418
E+ GR E+E + S L E E S + T +Q+ E
Sbjct: 957 EAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAH 1016
Query: 419 LPDLPGAEVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVE 478
L GA L + + + + +E + +L QN +L ++ ++LE+ + + E
Sbjct: 1017 LEAEEGARQKLQLE-KVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAE 1075
Query: 479 ALAEVIPL----ALYDSLRAEFDQLRRQHAEALQAL--------------------RQQE 514
+V L Y++ A+ + R+ + Q L +QQ
Sbjct: 1076 EEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQR 1135
Query: 515 TREVPREEGAACGESEVAGATATKNGPTHMELNGSV--APETKVNGAETIDEEAAG---- 568
E+ + G E + A A A G +L S+ A E ++ E
Sbjct: 1136 AEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKA 1195
Query: 569 -------DETMEARTMEAEATGAEATGA----------EATGAKVT---ETKPTGAEVRE 608
E +EA E E T ++T A E T K T ET+ A V+E
Sbjct: 1196 EKQRRDLGEELEALRGELEDT-LDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1254
Query: 609 METTEEEA------NMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQA 662
+ +A +E G A + +EA E ++ +AE + +Q G+
Sbjct: 1255 LRQRHGQALGELAEQLEQARRGKGAWEKTRLALEA---EVSELRAELSSLQT-ARQEGEQ 1310
Query: 663 EPPVTGTTNMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQ 722
E G G + +A ++ +A + +S GA +E
Sbjct: 1311 RRRRLELQLQEVQGRAGDGERARAEAAEKLQR--AQAELENVS-------GALNEAESKT 1361
Query: 723 VELETRIRGLEEALRQREREAAAELEAAL---GKCEAAEAEAGRLRERVREAEGSGASGG 779
+ L + E L + E A L + A EAEA LRE++ E
Sbjct: 1362 IRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE-------- 1413
Query: 780 GGGDTTQLRAALEQAREDLRDRDSRL----RELEAASACLDEARASRLLAEEEARGLRAE 835
AA E+A +L+ ++L R E + L+ +R A EA L
Sbjct: 1414 --------AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQR 1465
Query: 836 LAQREEA--RLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPA--- 890
LA++ E RLE+ R L+++L A EQQR + L + + + +AE A
Sbjct: 1466 LAEKTETVDRLERGRRR--LQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVL 1523
Query: 891 -ACEEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAAR 949
A EE + AE RE EA S+ A E + E LE + RA E E + + K+
Sbjct: 1524 RAVEERERAEAEGRE-REARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVG 1582
Query: 950 LRAELERERVCSVALSEHERIVGTLQANVAQLEGQL--EELGRRHEKTSAEVFQVQREAL 1007
++ E ER C VA E+ L+A V +LE +L E + + + + + Q E
Sbjct: 1583 -KSVHELERACRVA----EQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHER- 1636
Query: 1008 FMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFN 1067
++ A E + +QLR E + R+ ++ A A K+ + ++ EL ++ +
Sbjct: 1637 DLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAA---RKKLEGELEELKAQMAS 1693
Query: 1068 LKEALKEQPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDED 1127
+ +E A ++ ++ Q+K+L ++++E + + R ++G ++ +
Sbjct: 1694 AGQGKEE-----AVKQLRKMQAQMKELWREVEETRTSREEIFSQNRES-EKRLKG-LEAE 1746
Query: 1128 VQRILSQILQMQRLQAQGR 1146
V R+ ++ R + Q +
Sbjct: 1747 VLRLQEELAASDRARRQAQ 1765
Score = 95.5 bits (236), Expect = 3e-19
Identities = 188/839 (22%), Positives = 308/839 (36%), Gaps = 113/839 (13%)
Query: 320 RDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPE-----ASSLHILERQVQELQ--- 371
RD EE+ LR E L ++ + +R+QE E I E VQEL+
Sbjct: 1200 RDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRH 1259
Query: 372 -QLLVERQEEKESLGREVESLQSRLSLLENERENTSYDVTTLQD--EEGELPDLPGAEVL 428
Q L E E+ E R + + LE E ++++LQ +EGE
Sbjct: 1260 GQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGE---------- 1309
Query: 429 LSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIPLAL 488
Q + L +Q + R E EK+Q Q E+E ++ + A
Sbjct: 1310 ---QRRRRLELQLQEVQGRAGDGERARAEAAEKLQ--------RAQAELENVSGALNEAE 1358
Query: 489 YDSLR--AEFDQLRRQHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTHMEL 546
++R E Q +A + L+++ ++ E+E AG
Sbjct: 1359 SKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGL------------ 1406
Query: 547 NGSVAPETKVNGAETIDEEAAGDET--MEARTMEAEATGAEATGAEATGAKVTETKPTGA 604
E ++EEAA E E +T +A+ + E GA G
Sbjct: 1407 ------------REQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGA-----LEAGE 1449
Query: 605 EVREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEP 664
E R E EA T A TET G + + ++A M Q
Sbjct: 1450 EARRRAAREAEA-----LTQRLAEKTETVDRLERGRRRLQQELDDATMD-----LEQQRQ 1499
Query: 665 PVTGTTNMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVE 724
V+ + + E V E EA A + A E ++ + E
Sbjct: 1500 LVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREE 1559
Query: 725 LETRIRGLE---EALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEG--SGASGG 779
LE + R L EAL + + + C AE A LR +V E E + A
Sbjct: 1560 LERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDA 1619
Query: 780 GGGDTTQLRAALEQAREDLRDRDSR--------LRELEAASACLDEARASRLLA------ 825
++A Q DL+ RD ++L A DE R R LA
Sbjct: 1620 KLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKK 1679
Query: 826 -EEEARGLRAELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEAR 884
E E L+A++A + + E ++L ++ Q+ E+ RT+ E+ +E R
Sbjct: 1680 LEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKR 1739
Query: 885 VAELPAACEEARQGLAELREASEALRQSVVPASEH--------RRLQEEALELRGRAASL 936
+ L A ++ LA A +Q ++ + EE +L GR L
Sbjct: 1740 LKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQL 1799
Query: 937 EQEVVATGKEAA----RLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEEL-GRR 991
E+E+ + R R L + + LS ++ QLE Q++EL GR
Sbjct: 1800 EEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1859
Query: 992 HEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKA 1051
E+ + + + ++S+ AE QL EQ+ R + R+A+ R +E + +
Sbjct: 1860 GEEDAGARARHKMTIAALESKLAQAEEQL---EQETRERILSGKLVRRAEKRLKEVVLQV 1916
Query: 1052 KEKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQV--KDLQQQLQEAARDHSSV 1108
+E+ + +L ++ +K+ L E EA R Q + LQ++L++ S+
Sbjct: 1917 EEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESM 1975
Score = 79.7 bits (195), Expect = 1e-14
Identities = 188/829 (22%), Positives = 316/829 (38%), Gaps = 97/829 (11%)
Query: 294 SSHGKQGAPKKRKAPPPPASIPMPDDRDAYEEIVR-LRQERGRLLQKIRGLEQHKERRQQ 352
S++ +Q KR+ + ++ +E V+ LRQ G+ L ++ EQ ++ R+
Sbjct: 1219 STNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELA--EQLEQARRG 1276
Query: 353 ESPEASSLHILERQVQELQQLLV-------ERQEEKESLGREVESLQSRLSLLENERENT 405
+ + LE +V EL+ L E ++ + L +++ +Q R E R
Sbjct: 1277 KGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEA 1336
Query: 406 SYDVTTLQDE----EGELPDLPGAEVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEK 461
+ + Q E G L + + LS++LS S + L QE + TR L +
Sbjct: 1337 AEKLQRAQAELENVSGALNEAESKTIRLSKELS-STEAQLHDAQELLQEETRAKLALGSR 1395
Query: 462 VQILENFEKD-ETQMEVEALAEVIPLALYDSLRAEFDQLRRQHAEALQAL------RQQE 514
V+ +E Q+E EA A + +A+ + RR+ E AL R++
Sbjct: 1396 VRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRA 1455
Query: 515 TREVPREEGAACGESEVAGATATKNGPTHMELNGSVAP--------ETKVNGAETIDEEA 566
RE ++E EL+ + T D+
Sbjct: 1456 AREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLL 1515
Query: 567 AGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEVREMETTEEEANMETKPTGAQ 626
A ++ R +E E AEA G E ++ T+ E E E + A
Sbjct: 1516 AEEKAAVLRAVE-ERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEAL 1574
Query: 627 ATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRATGMESTG 686
+ + G +E AE+A A VT + E T + +
Sbjct: 1575 LSSKDDVGKSVHELERACRVAEQA--------ANDLRAQVTELED-ELTAAEDAKLR--- 1622
Query: 687 VSATGVENPGVEATVPGISAGPILH-PGAAEASEKLQVELETRIRGLE----EALRQRER 741
+E TV + G EA E+ + +L ++R E E +QR
Sbjct: 1623 ----------LEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTL 1672
Query: 742 EAAA--ELEAALGKCEAAEAEAGRLRER-VREAEGSGASGGG-GGDTTQLRAALEQARED 797
AA +LE L + +A A AG+ +E V++ A + + R + E+
Sbjct: 1673 AVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQ 1732
Query: 798 LRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQR-------EEARLEQSREL 850
R+ + RL+ LEA L E A+ A +A+ R E+A + A LE+ R+L
Sbjct: 1733 NRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQL 1792
Query: 851 E----VLREQLATARATGE-----------QQRTAAAELGRARD---AAEARVAELPAAC 892
E L E+L ++ E Q + EL R AE+ +L
Sbjct: 1793 EGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQI 1852
Query: 893 EEARQGLAELREASEALRQSVVPASEHRRLQ-EEALELRGRAASLEQEVVATGKEAAR-- 949
+E R L E + A + + A E + Q EE LE R L ++V ++ +
Sbjct: 1853 QELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEV 1912
Query: 950 -LRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALF 1008
L+ E ER RV + E+ G L+ V QL+ QLEE + A ++QRE
Sbjct: 1913 VLQVEEER-RVADQLRDQLEK--GNLR--VKQLKRQLEEAEEEASRAQAGRRRLQRELED 1967
Query: 1009 MKSERHAAEAQLATAEQQL-RGLRTEAERARQAQSRAQEALDKAKEKDK 1056
+ + ++ T +L RG T R + R +E + +E ++
Sbjct: 1968 VTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASDEEAEE 2016
Score = 57.4 bits (137), Expect = 8e-08
Identities = 78/297 (26%), Positives = 132/297 (44%), Gaps = 49/297 (16%)
Query: 844 LEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAE-L 902
L+ +R+ EVL+ + + E Q+ +A E+G + RVA+L EE R LAE L
Sbjct: 903 LQVTRQDEVLQARAQELQKVQELQQQSAREVGE----LQGRVAQL----EEERARLAEQL 954
Query: 903 REASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSV 962
R +E L EA E RGR A+ +QE+ E L A + E CS
Sbjct: 955 RAEAE--------------LCAEAEETRGRLAARKQELELVVSE---LEARVGEEEECSR 997
Query: 963 ALSEHERIVGTLQANVAQLEGQLE-ELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLA 1021
+ ++ LQ ++ +LE LE E G R ++Q E + +++ E L
Sbjct: 998 QMQTEKK---RLQQHIQELEAHLEAEEGARQ--------KLQLEKVTTEAKMKKFEEDLL 1046
Query: 1022 TAEQQLRGLRTE----AERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPA 1077
E Q L E +R + S+A E +K K +K + + ++++ L+++
Sbjct: 1047 LLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEK 1106
Query: 1078 ALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDVQRILSQ 1134
E+E L+ ++ +LQE V R+ L A G+ +E++Q L++
Sbjct: 1107 --GRQELEKLKRRLDGESSELQE-----QMVEQQQRAEELRAQLGRKEEELQAALAR 1156
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 109 bits (273), Expect = 1e-23
Identities = 225/911 (24%), Positives = 337/911 (36%), Gaps = 165/911 (18%)
Query: 301 APKKRKAPPPPASIPMPDDRDAYEEIVRLRQE---RGRLL----QKIRGLEQHKERRQQE 353
AP + A P + + +A ++ RLRQE + LL +++GLE R +QE
Sbjct: 243 APSRAPAEGPSHHLAL-QLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQE 301
Query: 354 SPEASSLHILERQVQELQQLLVERQEEKESLGREVESLQSRLSLLENERENTSYDVTTLQ 413
+ S +E + L ER L E+ + RL E + + L+
Sbjct: 302 AQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYK-------SQLE 354
Query: 414 DEEGELPDLPGAEVLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDET 473
+E L ++ LL QL +A+E A L E Q + L+ + ++
Sbjct: 355 EERVLSGVLEASKALLEEQLE-AARERCARLHE------TQRENLLLRTRL--------- 398
Query: 474 QMEVEALAEVIPLALYDSLRAEFDQLRRQHAEALQALRQQETREVPREEGAACGESEVAG 533
EA AE+ DSLR + DQL ++ E L Q + E P + GE+ +AG
Sbjct: 399 ---GEAHAEL------DSLRHQVDQLAEENVEL--ELELQRSLEPP---PGSPGEAPLAG 444
Query: 534 ATATKNGPTHMELNGSVAPETKVNG-----AETIDEEAAGDETMEARTME-------AEA 581
A + G + + N + + + G + E EA
Sbjct: 445 AAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEA 504
Query: 582 TGAEATGAEATGAKVTETKPTGAEVREMETTEEEANMETKPTGAQATDTETTGVEAMGVE 641
+ V + + G + ++ ++ +E QA D++ E
Sbjct: 505 PQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAE----- 559
Query: 642 ATKTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRATGMESTGVSATGVENPGVEATV 701
+ +A + QA ++ PV + E G R++ V+ + PG +
Sbjct: 560 -SPLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAPP--QGPGTKIQA 616
Query: 702 PGI-----------------------SAGPILHPGAAEASEKLQVELETRIRGLEEALRQ 738
P + GP PG +E S E E +GL+ A Q
Sbjct: 617 PQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQ 676
Query: 739 RE-REAAAELEAAL---GKCEAAEAEAGRLRERVREAEGSGASGGGGGDTTQLRAALEQA 794
E RE LE + + + G L +V E G S G EQ
Sbjct: 677 AEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASG--------VAEQ- 727
Query: 795 REDLRDRDSRLRELEAASACLDEARASRLLAEE-EARGLRAELAQREEARLEQSRELEVL 853
E LR+ ++LR A EA+A +L A+ EA L ELAQ A E RE E
Sbjct: 728 -EALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQ 786
Query: 854 REQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAE---LREASEALR 910
+ A R E A EL A EA V L AA E RQ E LR SEA
Sbjct: 787 AWEQARLR---EAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAE 843
Query: 911 QSV-VPASEHRRLQEEALELRGRAASLEQEV---VATGKE-AARL--------RAELERE 957
+ + V SE R+ EEA R +L+ E+ V GKE ARL +A LER+
Sbjct: 844 ERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQ 903
Query: 958 RVCSVALSEHERIVG-------TLQANVAQLEGQLEELGRRHEKTSAEVFQ--------- 1001
S+H+R G LQA E L EL R + E+FQ
Sbjct: 904 EFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLG 963
Query: 1002 -------------------VQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQS 1042
V+R + +E+ A + QL E QL L+ A+
Sbjct: 964 PKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQ 1023
Query: 1043 RAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQQQLQEAA 1102
RAQE + + + + +E+ E L+E EV A R ++ + Q Q
Sbjct: 1024 RAQEHSSRLQAEKSVLEIQGQELHRKLEVLEE--------EVRAARQSQEETRGQQQALL 1075
Query: 1103 RDHSSVVALYR 1113
RDH ++ L R
Sbjct: 1076 RDHKALAQLQR 1086
Score = 103 bits (256), Expect = 1e-21
Identities = 183/825 (22%), Positives = 319/825 (38%), Gaps = 103/825 (12%)
Query: 358 SSLHILERQVQELQQLLVERQEEKESLGREVESLQSRLSLLENERENTSY---DVTTLQD 414
+ L L ++++E +LL++ Q E + L E+ L+ L + + + L++
Sbjct: 265 AQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRE 324
Query: 415 EEGELPDLPGAEVLLSRQLSPSAQEHLASLQEQ----------VAVLTRQNQELMEKVQI 464
G LP L E+ R+ +A+ + + L+E+ A+L Q + E+
Sbjct: 325 RAGRLPRLQ-EELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCAR 383
Query: 465 LENFEKDETQMEV---EALAEVIPLALYDSLRAEFDQLRRQHAEALQALRQQETREVPRE 521
L +++ + EA AE+ DSLR + DQL ++ E L Q + E P
Sbjct: 384 LHETQRENLLLRTRLGEAHAEL------DSLRHQVDQLAEENVEL--ELELQRSLEPPP- 434
Query: 522 EGAACGESEVAGATATKNGPTHMELNGSVAPETKVNGA-----ETIDEEAAGDETMEART 576
+ GE+ +AGA + G + + N + + + G +
Sbjct: 435 --GSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAP 492
Query: 577 ME-------AEATGAEATGAEATGAKVTETKPTGAEVREMETTEEEANMETKPTGAQATD 629
E EA + V + + G + ++ ++ +E QA D
Sbjct: 493 REDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPD 552
Query: 630 TETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRATGMESTGVSA 689
++ E+ +A + QA ++ PV + E G R++ V+
Sbjct: 553 SDPQEAES------PLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSSLQSPASVAP 606
Query: 690 TGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIRGLEEALRQRE----REAAA 745
+ PG + P + G E E Q EL GL + + + ++
Sbjct: 607 P--QGPGTKIQAPQLLGGE------TEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSV 658
Query: 746 ELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRL 805
+LE G + + G+ R + G + A + + +
Sbjct: 659 QLEEQEGPNQGLDLATGQAEAREHDQRLEGT-------------VRDPAWQKPQQKSEGA 705
Query: 806 RELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQSRELEVLREQLATARATGE 865
E++ + + +AE+EA LR E+AQ R+ E L ++L E
Sbjct: 706 LEVQVWEGPIPGESLASGVAEQEA--LREEVAQLR-------RKAEALGDELEAQARKLE 756
Query: 866 QQRTAAAELGRARDAAEARVAELPAACEEARQGL--AELREASEALRQSVVPASEHRRLQ 923
Q T AA L +++ A+AR AE A E Q A LREA EA Q + AS+ R
Sbjct: 757 AQNTEAARL--SKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREAL 814
Query: 924 EEALELRGRAASLEQEVVATGKEAARLRAEL----ERERVCSVALSEHERIVGTLQANVA 979
EAL GR E +E +RLRA+ ER +V +H +
Sbjct: 815 VEALAAAGR------ERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKE 868
Query: 980 QLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQ 1039
L+ +LE+ R ++ A + +QRE ER + + Q+ +GL E Q
Sbjct: 869 ALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQ 928
Query: 1040 AQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQQQLQ 1099
A + ++E + E + +L +E+F L++ PA L P+ A V+ +L
Sbjct: 929 AAATSKE--EALMELKTRALQLEEELFQLRQG----PAGLG-PKKRAEPQLVETQNVRLI 981
Query: 1100 EAARDHSSVVA--LYRSHLLYAIQGQMDEDVQRILSQILQMQRLQ 1142
E R ++ +VA L ++GQ+ R +LQ QR Q
Sbjct: 982 EVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQ 1026
Score = 92.8 bits (229), Expect = 2e-18
Identities = 212/960 (22%), Positives = 360/960 (37%), Gaps = 167/960 (17%)
Query: 320 RDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQE 379
R+ + RL++E R ++++ E +K + ++E + L + ++E + ER
Sbjct: 323 RERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCA 382
Query: 380 EKESLGREVESLQSRLSLLENERENTSYDVTTLQDEEGEL-----------PDLPGAEVL 428
RE L++RL E ++ + V L +E EL P PG L
Sbjct: 383 RLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPL 442
Query: 429 LSRQLSPSAQEHLASLQE-QVAVLTRQNQELMEKVQI----------LENFEKDETQMEV 477
+PS Q+ + + ++ L R+N+EL +Q+ L +++ + V
Sbjct: 443 AGA--APSLQDEVREAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPV 500
Query: 478 EALAEVIPLALYDSLRAEFDQLRRQHAEALQ----------------------------- 508
A P+A S + + R +AL
Sbjct: 501 LEEAPQTPVAFDHSPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAES 560
Query: 509 -----ALRQQETREVPREEGAACGESEVAGATATKNGPTHMELNGSVAPE----TKVNGA 559
A+ Q + P+E G+ E ++ ++ SVAP TK+
Sbjct: 561 PLQAAAMDPQASDWSPQESGSPVETQESPEKAGRRSS---LQSPASVAPPQGPGTKIQAP 617
Query: 560 ETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEVREMETTEEEANME 619
+ + E G E + + EA G G E K ++P+ ++ E E + ++
Sbjct: 618 QLLGGETEGREAPQGELVP-EAWGLRQEGPEH---KPGPSEPSSVQLEEQEGPNQGLDLA 673
Query: 620 TKPTGAQATDTETTG-VEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSR 678
T A+ D G V + + K+E A G E +G EA
Sbjct: 674 TGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQEALREE 733
Query: 679 ATGMESTGVS-ATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIRGLEEA-L 736
+ + +E + A + A + + E + E+A L
Sbjct: 734 VAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARL 793
Query: 737 RQREREAAAELEAALGKCEA---AEAEAGRLRERVREAEGSGASGGGGGDTTQLRAALEQ 793
R+ A ELE+A + EA A A AGR R R E EGS +++ +
Sbjct: 794 REAVEAAGQELESASQEREALVEALAAAGRER-RQWEREGSRLRAQSEAAEERMQVLESE 852
Query: 794 AREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQSRELEVL 853
R+ L + + RE EA A L++A + + G R E QRE + R+ E L
Sbjct: 853 GRQHLEEAERERREKEALQAELEKA-----VVRGKELGARLEHLQRELEQAALERQ-EFL 906
Query: 854 REQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEAL---- 909
RE+ + + ++ AEL A + E + EL + + L +LR+ L
Sbjct: 907 REKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKK 966
Query: 910 ------------------RQSVVPASEHRRLQEEALELRGRAASLE---QEVVATGKEA- 947
R + + +E LQ + L G+ SL+ QE++ + A
Sbjct: 967 RAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQ 1026
Query: 948 ---ARLRAE----------LER-----ERVCSVALSEHERIVGTLQA------NVAQL-- 981
+RL+AE L R E A E G QA +AQL
Sbjct: 1027 EHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQR 1086
Query: 982 --EGQLEELGRRHEKTSAEVF-------QVQREALFMKSERHAAEAQ----LATAEQQL- 1027
E +LE L RH A + ++Q ++++R + EAQ LA E+ +
Sbjct: 1087 RQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQ 1146
Query: 1028 -----RGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATP 1082
RGL E R + RAQ L ELS+E L+ E LA
Sbjct: 1147 DGHRQRGLEEELRRLQSEHDRAQMLL----------AELSRERGELQGERGELRGRLARL 1196
Query: 1083 EVEALRDQVKDLQQQLQEAAR--DHSSVVALYRSHLLYAIQGQMDEDVQRILSQILQMQR 1140
E+E R Q++ QQL+E+ + D S+ + LL ++ +E+ +++L+++ + R
Sbjct: 1197 ELE--RAQLEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSR 1254
Score = 56.2 bits (134), Expect = 2e-07
Identities = 74/241 (30%), Positives = 102/241 (42%), Gaps = 46/241 (19%)
Query: 799 RDRD---SRLREL--EAASACLDEARASRLLAEEEARGLRAELAQREEARLEQSRELEVL 853
R+RD RL EL E CL SR AE + L +LA + +ELE
Sbjct: 218 RERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEK 277
Query: 854 REQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAEL-REASEALRQS 912
E L ++A + + AE+ R R A+A + AEL RE +EALR+
Sbjct: 278 AELLLDSQA---EVQGLEAEIRRLRQEAQALSGQAKR---------AELYREEAEALRER 325
Query: 913 VVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHERIVG 972
A RLQEE R R + E +++LE ERV S G
Sbjct: 326 ---AGRLPRLQEELRRCRERLQAAE-----------AYKSQLEEERVLS----------G 361
Query: 973 TLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRT 1032
L+A+ A LE QLE R A + + QRE L +++ A A+L + Q+ L
Sbjct: 362 VLEASKALLEEQLEAARER----CARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAE 417
Query: 1033 E 1033
E
Sbjct: 418 E 418
Score = 48.9 bits (115), Expect = 3e-05
Identities = 83/347 (23%), Positives = 135/347 (38%), Gaps = 57/347 (16%)
Query: 327 VRLRQERGRLLQ---KIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKES 383
V L ER RL+Q + RGLE+ R Q E A Q LL E E+
Sbjct: 1135 VALLAERERLMQDGHRQRGLEEELRRLQSEHDRA-------------QMLLAELSRERGE 1181
Query: 384 LGREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVL----LSRQLSPSAQE 439
L E L+ RL+ LE ER L++ +L DL + L QL + +E
Sbjct: 1182 LQGERGELRGRLARLELERAQLEMQSQQLRESNQQL-DLSACRLTTQCELLTQLRSAQEE 1240
Query: 440 HLASLQEQVAVLTRQNQELMEK-VQILENFEKDETQM--EVEAL---AEVIPLALYDSLR 493
L +V L+R+N+EL+E+ ++ ++ +++ + ++ AL + + + D R
Sbjct: 1241 ENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKIMDQYR 1300
Query: 494 A-EFDQLRRQHAEALQALRQQETREVPREEGAACG----ESEVAGATATKNGPTHMEL-- 546
E L R + A + + PR EG G ++ AG+T + GP EL
Sbjct: 1301 VLEPVPLPRTKKGSWLADKVKRLMR-PRREGGPPGGLRLGADGAGSTESLGGPPETELPE 1359
Query: 547 ------NGSVAPETKVNGAETI---DEEAAGDETMEARTMEAEATGAEATGAEAT----- 592
GS +P ++ DE AG + + + +E+ T
Sbjct: 1360 GREADGTGSPSPAPMRRAQSSLCLRDETLAGGQRRKLSSRFPVGRSSESFSPGDTPRQRF 1419
Query: 593 --------GAKVTETKPTGAEVREMETTEEEANMETKPTGAQATDTE 631
GA V+ +K G T +E + G + + E
Sbjct: 1420 RQRHPGPLGAPVSHSKGPGVGWENSAETLQEHETDANREGPEVQEPE 1466
Score = 40.8 bits (94), Expect = 0.007
Identities = 63/234 (26%), Positives = 102/234 (43%), Gaps = 37/234 (15%)
Query: 920 RRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHERIVGTLQANVA 979
R +Q +LE++ A+ QEV G A + L +A +E E + +L ++
Sbjct: 158 RHIQGLSLEVQSELAAAIQEVTQPG---AGVVLALSGPDPGELAPAELEMLSRSLMGTLS 214
Query: 980 QLEGQLEELGRRHEKTSAEVFQVQREALFMKSER----------HAAEAQLATAEQQLRG 1029
+L + +LG + AE+ ++RE L ++ E H QLA A+ QLR
Sbjct: 215 KLARE-RDLGAQR---LAELL-LEREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRR 269
Query: 1030 LRTEAERARQAQSRAQEALDKAKE---KDKKITELSKEVFNLKEALKEQPAALATPEVEA 1086
LR E E +A+ LD E + +I L +E L K A L E EA
Sbjct: 270 LRQELE------EKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKR--AELYREEAEA 321
Query: 1087 LRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDVQRILSQILQMQR 1140
LR++ L + +E R R A + Q++E +R+LS +L+ +
Sbjct: 322 LRERAGRLPRLQEELRRCRE------RLQAAEAYKSQLEE--ERVLSGVLEASK 367
Score = 35.8 bits (81), Expect = 0.24
Identities = 49/194 (25%), Positives = 85/194 (43%), Gaps = 10/194 (5%)
Query: 336 LLQKIRGLE-QHKE---RRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVESL 391
L +R LE H+E R +Q + +S+ E + ++ L++ + L E+ L
Sbjct: 1102 LKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRL 1161
Query: 392 QSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSAQEHLASLQE---QV 448
QS + S + LQ E GEL L QL +Q+ S Q+
Sbjct: 1162 QSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSA 1221
Query: 449 AVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIPLALYDSL--RAEFDQLRRQHAEA 506
LT Q EL+ +++ + E + EV+AL+ L SL R + +R++ +
Sbjct: 1222 CRLTTQ-CELLTQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQ 1280
Query: 507 LQALRQQETREVPR 520
L ALR+++ + V +
Sbjct: 1281 LNALRREKQKLVEK 1294
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 109 bits (272), Expect = 2e-23
Identities = 194/798 (24%), Positives = 318/798 (39%), Gaps = 99/798 (12%)
Query: 315 PMPDDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLL 374
P+ A EE+ LR E L+ +RG E ++QE E H+ QE L
Sbjct: 887 PLLRSAQAEEELAALRAE----LRGLRGALAAAEAKRQELEET---HV--SITQEKNDLA 937
Query: 375 VERQEEKESLGREVES----LQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVLLS 430
++ Q E+++L E ++S++ L +E + L+DEE DL
Sbjct: 938 LQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSE----RLEDEEEVNADLAARR---- 989
Query: 431 RQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIPLALYD 490
R+L E + + L + +E Q EN K+ T+ E+ AL E +
Sbjct: 990 RKLEDECTELKKDIDDLKLTLAKAEKEK----QATENKVKNLTE-EMAALDESVA----- 1039
Query: 491 SLRAEFDQLRRQHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTHMELNGSV 550
L E L+ H +AL L+ +E R + E +V + + ++
Sbjct: 1040 RLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTER 1099
Query: 551 APETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEVREME 610
A + K+ G + +E+ D + + +E + ++ ++ + +V + + GA++++ +
Sbjct: 1100 A-KRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLS-LRVEDEQLLGAQMQK-K 1156
Query: 611 TTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEM--QAYGVGAGQAEPPVTG 668
E +A E +A VE EA + E +E +A G AGQ E G
Sbjct: 1157 IKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQRE----G 1212
Query: 669 TTNMEAT-GSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELET 727
EA G +E + EATV + GAAE E QV+
Sbjct: 1213 CRKREAELGRLRRELEEAALRH--------EATVAALRRKQA--EGAAELGE--QVDSLQ 1260
Query: 728 RIRGLEEALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGDTTQL 787
R+R E + R +L A + A+A A +L R E + S A QL
Sbjct: 1261 RVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLC-RTYEDQLSEAKIKVEELQRQL 1319
Query: 788 RAALEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQS 847
A Q + R LE + + + LA + LR +L + +A+ +
Sbjct: 1320 ADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALA 1379
Query: 848 RELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACE-EARQGLAELREAS 906
++ LR R E++ A AEL R A A VA+ + E +A Q EL EA
Sbjct: 1380 HAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAK 1439
Query: 907 EALRQSVVPASEHRRLQEEALEL-RGRAASLEQEVVATGKEAARLRAELERERVCSVALS 965
+ L + A EE +E + +SLE+ + E+ + ELER + AL
Sbjct: 1440 KKLALRLQEA-------EEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALD 1492
Query: 966 EHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQ 1025
+ +R LE LEE R+ E+ E+ QRE+
Sbjct: 1493 KKQR----------HLERALEERRRQEEEMQRELEAAQRES------------------- 1523
Query: 1026 QLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPE-- 1083
RGL TE R R A EAL+ K ++K + E E+ +L + + ++ E
Sbjct: 1524 --RGLGTELFRLRHGHEEALEALETLKRENKNLQE---EISDLTDQVSLSGKSIQELEKT 1578
Query: 1084 VEALRDQVKDLQQQLQEA 1101
+AL + ++Q L+EA
Sbjct: 1579 KKALEGEKSEIQAALEEA 1596
Score = 106 bits (264), Expect = 1e-22
Identities = 183/769 (23%), Positives = 310/769 (40%), Gaps = 83/769 (10%)
Query: 337 LQKIRG-LEQHK-ERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVESLQSR 394
LQ++R LE+ K E R + A+++ L R ++L +++ +VE LQ +
Sbjct: 1259 LQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQ 1318
Query: 395 LSLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPS---AQEHLASLQEQVAVL 451
L+ +R LQ E GEL L + L QLS A + L L+ Q+
Sbjct: 1319 LADASTQRGR-------LQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEE 1371
Query: 452 TRQNQELMEKVQILEN---FEKDETQMEVEALAEVIPLALYDSLRAEFDQLRRQH-AEAL 507
++ L VQ L + +++ + E EA AE+ L AE Q R ++ A+A+
Sbjct: 1372 SKAKSALAHAVQALRHDCDLLREQHEEEAEAQAEL--QRLLSKANAEVAQWRSKYEADAI 1429
Query: 508 Q------------ALRQQETREVPREEGAACGESEVAGATA-TKNGPTHMELNGSVAPET 554
Q ALR QE E A C E A T++ +EL + +
Sbjct: 1430 QRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAA 1489
Query: 555 KVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEVREMETTEE 614
++ + E A + + M+ E A+ + G ++ + E E T +
Sbjct: 1490 ALDKKQRHLERALEERRRQEEEMQRELEAAQRE-SRGLGTELFRLRHGHEEALEALETLK 1548
Query: 615 EANMETKPTGAQATD-TETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTNME 673
N + + TD +G +E TK KA E E +AE G +E
Sbjct: 1549 RENKNLQEEISDLTDQVSLSGKSIQELEKTK-KALEGEKSEIQAALEEAE----GALELE 1603
Query: 674 ATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIRGLE 733
T + +E + V A V+ E + L A E LQ L+ R
Sbjct: 1604 ETKTLRIQLELSQVKAE-VDRKLAEKDEECAN----LRRNHQRAVESLQASLDAETRARN 1658
Query: 734 EALRQREREAAA--ELEAALGKC--EAAEAEAG-RLRERVREAEGSGASGGGGGDTTQLR 788
EALR +++ +LE LG +A EA+A RL + + E +G + +L
Sbjct: 1659 EALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRD-----EEQRLA 1713
Query: 789 AALEQAREDLRDRDSRLR-ELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQS 847
A L + + L R S L ELE A L++ SR LAE+E LE +
Sbjct: 1714 AELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQEL--------------LEAT 1759
Query: 848 RELEVLREQLATARATG--EQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREA 905
L +L Q TG Q++ A+L + E E A E+A++ + +
Sbjct: 1760 ERLNLLHSQ-----NTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMM 1814
Query: 906 SEALRQSVVPASEHRR----LQEEALELRGRAASLEQEVVATGK-EAARLRAELERERVC 960
+E L++ ++ R L++ EL+ R EQ + GK + +L A++ R
Sbjct: 1815 AEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKV---REL 1871
Query: 961 SVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQL 1020
L ++ V + E +++EL + E+ + ++Q ++S+ + + Q
Sbjct: 1872 EAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQF 1931
Query: 1021 ATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLK 1069
AEQQ + +A+ A+E D A+ + K+ +++ K
Sbjct: 1932 EEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTRDALGPK 1980
Score = 95.5 bits (236), Expect = 3e-19
Identities = 219/904 (24%), Positives = 359/904 (39%), Gaps = 153/904 (16%)
Query: 344 EQHKERRQQESPEASSLHILERQVQ----ELQQLLVERQEEKESLGREVESLQSRLSLLE 399
+Q +E+ +++ E S L + Q ++Q+ + E Q E L E+E+ ++ + +E
Sbjct: 1123 QQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVE 1182
Query: 400 NERENTSYDVTTLQDEEGELPDLPGAEV--------------LLSRQLSPSAQEHLASLQ 445
+R + ++ L + L + GA L R+L +A H A++
Sbjct: 1183 KQRAEAARELEELSER---LEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVA 1239
Query: 446 -------EQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIPLALYDSLRAEFDQ 498
E A L Q L Q LE EK E +MEV+ LA + +A ++
Sbjct: 1240 ALRRKQAEGAAELGEQVDSLQRVRQKLEK-EKSELRMEVDDLAANVETLT--RAKASAEK 1296
Query: 499 LRRQHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTHMELNGSVAPETKVNG 558
L R + + L + + E+ R+ A S G T++G L ++++
Sbjct: 1297 LCRTYEDQLSEAKIK-VEELQRQLADA---STQRGRLQTESGELSRLLEEKECLISQLSR 1352
Query: 559 AETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEVREMETTEEEANM 618
+ + A E R E + A++ A A A + +RE E EA
Sbjct: 1353 GKAL----AAQSLEELRRQLEEESKAKSALAHAVQALRHDCDL----LREQHEEEAEAQA 1404
Query: 619 ETKPTGAQATDTET---TGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTNMEAT 675
E + ++A + EA ++ T+ + EEA+ + + +AE V EA
Sbjct: 1405 ELQRLLSKANAEVAQWRSKYEADAIQRTE-ELEEAKKKL-ALRLQEAEEGV------EAA 1456
Query: 676 GSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIRGLEEA 735
++ + +E + E+ V + ++ AA A +K Q LE R LEE
Sbjct: 1457 NAKCSSLEKAKLRLQ-TESEDVTLELERATS-------AAAALDKKQRHLE---RALEER 1505
Query: 736 LRQREREAAAELEAALGKCEAAEAEAGRLRERVREA---------EGSGASGGGGGDTTQ 786
RQ E E ELEAA + E RLR EA E T Q
Sbjct: 1506 RRQEE-EMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQ 1564
Query: 787 LRAA------LEQAREDLRDRDSRLRE-LEAASACLDEARASRLLAEEEARGLRAE---- 835
+ + LE+ ++ L S ++ LE A L+ L + E ++AE
Sbjct: 1565 VSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRK 1624
Query: 836 LAQREEA----RLEQSRELEVLREQL-ATARATGEQQRTAAAELGRARDAAEARVAELPA 890
LA+++E R R +E L+ L A RA E R G D +L
Sbjct: 1625 LAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLE----LQLGH 1680
Query: 891 ACEEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARL 950
A +A + A R L++ E +RL A EL +A +LE+ E L
Sbjct: 1681 ATRQATEAQAATRLMQAQLKEEQAGRDEEQRL---AAELHEQAQALERRASLLAAELEEL 1737
Query: 951 RAELER-ERVCSVALSEHERIVGT-------------------LQANVAQLEGQLEELGR 990
RA LE+ ER S L+E E + T L+A++AQL G++EE +
Sbjct: 1738 RAALEQGER--SRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQ 1795
Query: 991 R----HEKTSAEVFQVQREALFMKSERHAA---EAQLATAEQQLRGLRTEAERARQAQSR 1043
EK + A +K E+ + E T EQ +R L+ E A QA R
Sbjct: 1796 ERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALR 1855
Query: 1044 -AQEALDKAKEKDKKI-TELSKEVFNLKEALK-----------------EQPAALATPE- 1083
++ + K + K +++ EL E EALK E LA +
Sbjct: 1856 GGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQD 1915
Query: 1084 -VEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDVQRILSQILQMQRLQ 1142
V+ L+ +VK ++Q +EA + ++ +A YR Q ++D+ +R Q +L+
Sbjct: 1916 LVDKLQSKVKSYKRQFEEAEQQANTNLAKYRK-----AQHELDDAEERADMAETQANKLR 1970
Query: 1143 AQGR 1146
A+ R
Sbjct: 1971 ARTR 1974
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 103 bits (258), Expect = 7e-22
Identities = 75/247 (30%), Positives = 104/247 (42%), Gaps = 33/247 (13%)
Query: 78 LDPEGKSAFHLAAMRGAASCLEVMIAHGSNVMSADGAGYNALHLAAKYGHPQCLKQLLQA 137
+D +G + H+AA G + + G++ LHLAA H C ++LL +
Sbjct: 310 VDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSS 369
Query: 138 SCVVDVVDSSGWTALHHAAAGGCLSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLC 197
+D D G T LH AAAGG + C ++L S A + +D+ G TPL AA CH
Sbjct: 370 GFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCI 429
Query: 198 RLLLQQGAAANDQDLQGRTALMLAC----------------------------EGASPET 229
L+ GA N+ D GRTAL A E +
Sbjct: 430 ETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLC 489
Query: 230 VEVLLQGGAQPGITDALGQDAAHYGALAGDKLILHLLQEAAQRPSPPSALTEDDSGEASS 289
+E LLQ A P I D G ++ HY A G + L LL E S E DSG S
Sbjct: 490 LEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTN-----SGFEESDSGATKS 544
Query: 290 QNSMSSH 296
++++
Sbjct: 545 PLHLAAY 551
Score = 93.6 bits (231), Expect = 1e-18
Identities = 62/202 (30%), Positives = 91/202 (45%), Gaps = 1/202 (0%)
Query: 67 LIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMIAHGSNVMSADGAGYNALHLAAKYG 126
L+ KG D + + A H AA G + ++I HG+ V D GY LH AA G
Sbjct: 133 LLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNG 192
Query: 127 HPQCLKQLLQASCVVDVVDSSGWTALHHAAAGGCLSCSEVLCSFKAHLNPQDRSGATPLI 186
+K LL +D ++ G TALH A G + L + A++N + +G TPL
Sbjct: 193 QINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLH 252
Query: 187 IAAQMCHTDLC-RLLLQQGAAANDQDLQGRTALMLACEGASPETVEVLLQGGAQPGITDA 245
AA H LC LL+ GA N Q G++ L + + L+Q G + D
Sbjct: 253 FAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDK 312
Query: 246 LGQDAAHYGALAGDKLILHLLQ 267
G H A G +L+++ L+
Sbjct: 313 DGNTPLHVAARYGHELLINTLR 334
Score = 90.9 bits (224), Expect = 6e-18
Identities = 70/200 (35%), Positives = 100/200 (50%), Gaps = 6/200 (3%)
Query: 75 PTKLDPEGKSAFHLAAMRGAASCLEVMIAHGSNVM--SADGAGYNALHLAAKYGHPQCLK 132
P+ D EG ++ H AA G CLE+++ ++ S GA + LHLAA GH Q L+
Sbjct: 500 PSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALE 559
Query: 133 QLLQASCVVDVVDSSGWTALHHAAAGGCLSCSEVLCSFKAHLNPQDR-SGATPLIIAAQM 191
LLQ+ +D+ D G TAL AA G C E L + A + +D + TPL +
Sbjct: 560 VLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVIN 619
Query: 192 CHTDLCRLLLQ---QGAAANDQDLQGRTALMLACEGASPETVEVLLQGGAQPGITDALGQ 248
HT RLLL+ A + +D +G+T LMLA + V +LL+ A D LG
Sbjct: 620 GHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGC 679
Query: 249 DAAHYGALAGDKLILHLLQE 268
A H G + G + + +L E
Sbjct: 680 TALHRGIMTGHEECVQMLLE 699
Score = 89.4 bits (220), Expect = 2e-17
Identities = 61/190 (32%), Positives = 91/190 (47%), Gaps = 1/190 (0%)
Query: 78 LDPEGKSAFHLAAMRGAASCLEVMIAHGSNVMSADGAGYNALHLAAKYGHPQCLKQLLQA 137
LD E ++ H+AA G A +E++I G+ V + D LH A + ++ L++
Sbjct: 12 LDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKH 71
Query: 138 SCVVDVVDSSGWTALHHAAAGGCLSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLC 197
S V+ D + T LH AAA + C+EV+ + +N DR G T L AA H ++
Sbjct: 72 SADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMV 131
Query: 198 RLLLQQGAAANDQDLQGRTALMLACEGASPETVEVLLQGGAQPGITDALGQDAAHYGALA 257
LLL +GA N D + R AL A + V +L+ GA+ D G H A
Sbjct: 132 NLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASN 191
Query: 258 GD-KLILHLL 266
G ++ HLL
Sbjct: 192 GQINVVKHLL 201
Score = 82.4 bits (202), Expect = 2e-15
Identities = 68/217 (31%), Positives = 99/217 (45%), Gaps = 7/217 (3%)
Query: 52 LLQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMIAHGSNVMSA 111
L +AV + V LI V + D ++ H+AA A C EV+I S+V +
Sbjct: 53 LHRAVASRSEEAVQVLIKHSADVNAR-DKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVS 111
Query: 112 DGAGYNALHLAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAGGCLSCSEVLCSFK 171
D G ALH AA GH + + LL ++ D ALH AA G L +L +
Sbjct: 112 DRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHG 171
Query: 172 AHLNPQDRSGATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALMLACEGASPETVE 231
A + +D+ G TPL AA ++ + LL G ++ ++ G TAL +AC V
Sbjct: 172 AEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVN 231
Query: 232 VLLQGGA---QP---GITDALGQDAAHYGALAGDKLI 262
L+ GA QP G T A+ +GAL + L+
Sbjct: 232 ELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLV 268
Score = 80.5 bits (197), Expect = 8e-15
Identities = 61/237 (25%), Positives = 95/237 (40%), Gaps = 34/237 (14%)
Query: 53 LQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMIAHGSNVMSAD 112
L A +N V + G+ +++ G +A H+A G + + +I +G+NV +
Sbjct: 185 LHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 244
Query: 113 GAGYNALHLAAKYGHPQ-CLKQLLQASCVVDVVDSSGWTALHHAAAGGCLSCSEVLCSFK 171
G+ LH AA H CL+ L+ V++ G + LH A G + S+ L
Sbjct: 245 NNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNG 304
Query: 172 AHLNPQDRSGATPLIIAAQM---------------------------------CHTDLCR 198
++ D+ G TPL +AA+ H+D CR
Sbjct: 305 GEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCR 364
Query: 199 LLLQQGAAANDQDLQGRTALMLACEGASPETVEVLLQGGAQPGITDALGQDAAHYGA 255
LL G + D GRT L A G + E +++L GA D G+ HY A
Sbjct: 365 KLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAA 421
Score = 79.7 bits (195), Expect = 1e-14
Identities = 69/228 (30%), Positives = 93/228 (40%), Gaps = 31/228 (13%)
Query: 77 KLDPEGKSAFHLAAMRGAASCLEVMIAHGSNVMSADGAGYNALHLAAKYGHPQ------- 129
K D G++ H AA C+E ++ G+NV D G ALH AA +
Sbjct: 408 KKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGN 467
Query: 130 ---------------------CLKQLLQASCVVDVVDSSGWTALHHAAAGGCLSCSEVLC 168
CL+ LLQ + D G+ ++H+AAA G C E+L
Sbjct: 468 AHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLL 527
Query: 169 SFKAHLNPQDRSGAT--PLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALMLACEGAS 226
+ SGAT PL +AA H +LLQ + +D +GRTAL LA
Sbjct: 528 ERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGH 587
Query: 227 PETVEVLLQGGAQPGITD-ALGQDAAHYGALAGDKLILHLLQEAAQRP 273
E VE L+ GA + D + H + G L L LL E A P
Sbjct: 588 TECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNP 635
Score = 79.3 bits (194), Expect = 2e-14
Identities = 68/234 (29%), Positives = 99/234 (42%), Gaps = 39/234 (16%)
Query: 47 KSDERLLQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMIAHGS 106
K L+ AV V+ L+ ++ V T +D G +A H M G C+++++
Sbjct: 644 KGQTPLMLAVAYGHIDAVSLLLEKEANVDT-VDILGCTALHRGIMTGHEECVQMLLEQEV 702
Query: 107 NVMSADGAGYNALHLAAKYGHPQCLKQLLQASCVVD---VVDSSGWTALHHAAAGGCLSC 163
+++ D G LH AA GH L +LLQ + + D+ G+T LH A G +C
Sbjct: 703 SILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENC 762
Query: 164 SEVL----CSFKAHLNP------------------------------QDRSGATPLIIAA 189
EVL C K NP +D G TPL AA
Sbjct: 763 IEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAA 822
Query: 190 QMCHTDLCRLLLQQGAAANDQDLQGRTALMLACEGASPETVEVLLQGGAQPGIT 243
H + +LLL+ A N D G+TALM+A E V++L+ AQ +T
Sbjct: 823 FADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILV-NSAQADLT 875
Score = 79.0 bits (193), Expect = 2e-14
Identities = 60/218 (27%), Positives = 94/218 (43%), Gaps = 1/218 (0%)
Query: 60 DAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMIAHGSNVMSADGAGYNAL 119
DA + LI V K D + H A + ++V+I H ++V + D L
Sbjct: 28 DAEIIELLILSGARVNAK-DNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPL 86
Query: 120 HLAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAGGCLSCSEVLCSFKAHLNPQDR 179
H+AA +C + ++ V+V D G TALHHAA G + +L + A++N D+
Sbjct: 87 HVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDK 146
Query: 180 SGATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALMLACEGASPETVEVLLQGGAQ 239
L AA M H D+ LL+ GA +D +G T L A V+ LL G +
Sbjct: 147 KDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVE 206
Query: 240 PGITDALGQDAAHYGALAGDKLILHLLQEAAQRPSPPS 277
+ G A H G +++ L + + P+
Sbjct: 207 IDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 244
Score = 77.0 bits (188), Expect = 9e-14
Identities = 52/175 (29%), Positives = 75/175 (42%)
Query: 81 EGKSAFHLAAMRGAASCLEVMIAHGSNVMSADGAGYNALHLAAKYGHPQCLKQLLQASCV 140
+GKS H+ A+ G + + +I +G + D G LH+AA+YGH + L +
Sbjct: 280 DGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD 339
Query: 141 VDVVDSSGWTALHHAAAGGCLSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLCRLL 200
LH AA C L S ++ D+ G T L AA + + +LL
Sbjct: 340 TAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLL 399
Query: 201 LQQGAAANDQDLQGRTALMLACEGASPETVEVLLQGGAQPGITDALGQDAAHYGA 255
GA + +D GRT L A +E L+ GA TD G+ A HY A
Sbjct: 400 QSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA 454
Score = 74.7 bits (182), Expect = 5e-13
Identities = 56/178 (31%), Positives = 77/178 (43%), Gaps = 6/178 (3%)
Query: 64 VAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMIAHGSN---VMSADGAGYNALH 120
V ALI + K + ++ H + + G CL +++ N V D G L
Sbjct: 591 VEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLM 650
Query: 121 LAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAGGCLSCSEVLCSFKAHLNPQDRS 180
LA YGH + LL+ VD VD G TALH G C ++L + + +D
Sbjct: 651 LAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSR 710
Query: 181 GATPLIIAAQMCHTDLCRLLLQQGAAAND---QDLQGRTALMLACEGASPETVEVLLQ 235
G TPL AA H LLQ + D +D QG T L AC + +EVLL+
Sbjct: 711 GRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768
Score = 63.9 bits (154), Expect = 8e-10
Identities = 47/167 (28%), Positives = 75/167 (44%)
Query: 100 VMIAHGSNVMSADGAGYNALHLAAKYGHPQCLKQLLQASCVVDVVDSSGWTALHHAAAGG 159
++I +V + D LH+AA G + ++ L+ + V+ D+ T LH A A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 160 CLSCSEVLCSFKAHLNPQDRSGATPLIIAAQMCHTDLCRLLLQQGAAANDQDLQGRTALM 219
+VL A +N +D++ TPL +AA +++ ++ N D GRTAL
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 220 LACEGASPETVEVLLQGGAQPGITDALGQDAAHYGALAGDKLILHLL 266
A E V +LL GA D + A H+ A G ++ LL
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALL 167
Score = 34.7 bits (78), Expect = 0.53
Identities = 22/84 (26%), Positives = 36/84 (42%), Gaps = 1/84 (1%)
Query: 53 LQAVENNDAPRVAALIARKGLVPTKLDPEGKSAFHLAAMRGAASCLEVMIAHGSNVMSAD 112
L+A D L+ R +D GK+A +AA G A +++++ ++
Sbjct: 818 LRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVK 877
Query: 113 GAGYNA-LHLAAKYGHPQCLKQLL 135
N LHLA GH +C +L
Sbjct: 878 DKDLNTPLHLACSKGHEKCALLIL 901
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 103 bits (258), Expect = 7e-22
Identities = 180/797 (22%), Positives = 310/797 (38%), Gaps = 102/797 (12%)
Query: 324 EEIVRLRQERGRLLQKIRGLEQHKERRQQE-------SPEASSLH----------ILERQ 366
EE ++R+E ++ R LE + Q+E P+ S + +LE
Sbjct: 890 EEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEES 949
Query: 367 VQELQQLLVERQEEKESLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAE 426
Q+LQ+ L E Q + + L E+E+LQ +L LE E + + + E PD A+
Sbjct: 950 FQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIE-PDRAQAD 1008
Query: 427 VLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIPL 486
+L +E L +L+ Q + L ++V L EK Q +V EV+ L
Sbjct: 1009 EVL------QLREELEALRRQKGAREAEVLLLQQRVAALAE-EKSRAQEKVTE-KEVVKL 1060
Query: 487 ALYDSLRAEFDQLRRQHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTHMEL 546
L AE+ QL+ H Q +QE ++ E E A A +++
Sbjct: 1061 QNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKV 1120
Query: 547 NGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATG--AEATGAEATGAKVTETKPTGA 604
A E +V+ E DE +AR + E T + E AKV +
Sbjct: 1121 EKDAATEREVSDLTRQYE----DEAAKARASQREKTELLRKIWALEEENAKVVVQE---- 1172
Query: 605 EVREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEP 664
+VRE+ + +A E + + E K + E ++++Y
Sbjct: 1173 KVREIVRPDPKAESEVANLRLELVEQE-----------RKYRGAEEQLRSY--------- 1212
Query: 665 PVTGTTNMEATGSRATGMESTGVSATGVE---NPGVEATVPGISAGPILHPGAAEASEKL 721
+ +EA R +E V+ ++ +P +E + + + E +
Sbjct: 1213 ----QSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLE 1268
Query: 722 QVELETRIRGLEEALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGG 781
+L+ I+ L++ Q + + + + + E LR ++ E +
Sbjct: 1269 IYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQV----- 1323
Query: 782 GDTTQLRAALEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARG---------- 831
D + RA+ E+ + SR++E + L AE A
Sbjct: 1324 -DLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQI 1382
Query: 832 --LRAELAQREEARLEQSRELEVL-REQLATARATGEQQRTAAAELGRARDAAEARVAEL 888
LRAEL + + R E R+LE L RE+ A A E QR ++ AEAR
Sbjct: 1383 DKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREKVT 1442
Query: 889 PAACEEARQGLAELREASEALRQSVVPASEHRR--LQEEALELRGRAASLEQE------V 940
+Q + RE AL + + +HRR L+ E LR + A+LE+ V
Sbjct: 1443 HTQKVVLQQDPQQARE--HALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVV 1500
Query: 941 VATGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVF 1000
++ + + E E +R+ S +L E R L V++LE +L EL + K+S
Sbjct: 1501 LSESVQVEKGDTEQEIQRLKS-SLEEESRSKRELDVEVSRLEARLSELEFHNSKSS---- 1555
Query: 1001 QVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERA--RQAQSRAQEALDKAKEKDKKI 1058
+E F++ E H + + + + R L++E A R D D ++
Sbjct: 1556 ---KELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRL 1612
Query: 1059 TELSKEVFNLKEALKEQ 1075
L +E+ +LK K++
Sbjct: 1613 WSLERELDDLKRLSKDK 1629
Score = 67.8 bits (164), Expect = 6e-11
Identities = 180/850 (21%), Positives = 323/850 (38%), Gaps = 153/850 (18%)
Query: 325 EIVRLRQERGRLLQKIRGLEQHKERRQQ--ESPEASSLHILERQVQELQQLLVE----RQ 378
++ R E +L Q+ L Q ERR Q +S +A+ H R + Q LV
Sbjct: 696 DLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHF-HRGHDHVLQFLVSIPSYEP 754
Query: 379 EEKESLGREVESLQSRLSLLEN----ERE------NTSYDVTTLQDEEGE---LPDLPGA 425
+E +SL + L+++ +LL+ E+E N+ ++D E E L L
Sbjct: 755 QETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDL 814
Query: 426 EVLLSRQLSPSA--QEHLASLQEQVAVLTRQ-------NQELMEKVQILENFEKDETQME 476
E S +S A Q ++E+ A L + N++ ++ ++ N + Q E
Sbjct: 815 ENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQ--QPE 872
Query: 477 VEALAEVIPLALYDSLRAEFDQLRRQHAEALQALRQQETREVPREEGAAC-----GESEV 531
VE E + DS E ++R++ E + RQ E +E + V
Sbjct: 873 VEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESV 932
Query: 532 AGATATKNGP------THMELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAE 585
K P + +L ++A E N + + EE + ++ R +E E
Sbjct: 933 VRKEVLKKVPDPVLEESFQQLQRTLAEEQHKN--QLLQEELEALQ-LQLRALEQETRDG- 988
Query: 586 ATGAEATGAKVTETKPTGAEVREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKT 645
G E +V +P A+ E+ EE + GA+ + + K+
Sbjct: 989 --GQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKS 1046
Query: 646 KAEEAEMQAYGVGAGQAEPPVTGTTNMEATGSRATGMESTGVSATGVENPGVEATVPGIS 705
+A+E + T +++ +P +EA +
Sbjct: 1047 RAQE-----------------------KVTEKEVVKLQN---------DPQLEAEYQQLQ 1074
Query: 706 AGPILHPGAAEASEKLQVELETRIRGLEEALRQREREAAAELEAALGKCEAAEAEAGRLR 765
+ ++L+ + E + L++ L++ E+E A A GK E
Sbjct: 1075 EDH-------QRQDQLREKQEEELSFLQDKLKRLEKERAM----AEGKITVKE------- 1116
Query: 766 ERVREAEGSGASGGGGGDTT-QLRAALEQAREDLRDRDSRLRELEAASACLDEARASRLL 824
V + E A+ D T Q +AR R++ LR++ A L+E A ++
Sbjct: 1117 --VLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWA----LEEENAKVVV 1170
Query: 825 -------------AEEEARGLRAELAQREEARLEQSRELEVLREQLATARATGEQQRTAA 871
AE E LR EL ++E +L + +L R G Q
Sbjct: 1171 QEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKE 1230
Query: 872 A-----------ELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEHR 920
E+ + + + E + +L++ +AL+ + P + +
Sbjct: 1231 VTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTK-PQVQTK 1289
Query: 921 RLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQ 980
+ +E L+ QE T +E A LRA+L E+ V L ER + + +A+
Sbjct: 1290 EVVQEILQF--------QEDPQTKEEVASLRAKLSEEQKKQVDL---ERERASQEEQIAR 1338
Query: 981 LEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQA 1040
E EEL R E+ + E +++E A + +Q+ LR E R ++
Sbjct: 1339 KE---EELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRR 1395
Query: 1041 QSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQ----Q 1096
++ + L++ + + + E +EV L++ L AAL E EA R++V Q Q
Sbjct: 1396 RTELERQLEELERERQARREAEREVQRLQQRL----AALEQEEAEA-REKVTHTQKVVLQ 1450
Query: 1097 QLQEAARDHS 1106
Q + AR+H+
Sbjct: 1451 QDPQQAREHA 1460
Score = 45.1 bits (105), Expect = 4e-04
Identities = 155/834 (18%), Positives = 315/834 (37%), Gaps = 130/834 (15%)
Query: 330 RQERGRLLQ--KIRGLEQHKERRQQESPEASSLHILERQVQELQ----QLLVERQEEKES 383
+Q +GR+ R L+ RRQ E+ +L E ++ +L QLL + S
Sbjct: 231 QQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNS 290
Query: 384 LGREVESLQSR----LSLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSAQE 439
+ +E++ + L+LL E + Y ++D D+ A+ LL + S Q+
Sbjct: 291 IEAHMEAVHADWKEYLNLLICEESHLKY----MEDYHQFHEDVKDAQELLRKVDSDLNQK 346
Query: 440 HLASLQE--QVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIPLALYDSLRAEFD 497
+ ++ Q+ +L R EL ++ ++L+ +E D Q + +V+PL
Sbjct: 347 YGPDFKDRYQIELLLR---ELDDQEKVLDKYE-DVVQGLQKRGQQVVPL----------- 391
Query: 498 QLRRQHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTHMEL-----NGSVAP 552
+ RR+ L+ + + + E+G S T KN EL N +AP
Sbjct: 392 KYRRE--TPLKPIPVEALCDFEGEQGLI---SRGYSYTLQKNNGESWELMDSAGNKLIAP 446
Query: 553 ETKVNGAETIDEEAAGDETM--EARTMEAEATGAEATGAEATGAKVTETKPTGAEVREME 610
T E A +++ + R++ +A G++ T + TE + +++
Sbjct: 447 AVCFVIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENP---GDASDLQ 503
Query: 611 TTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTT 670
+ A ++ + + TG+ +E + + AE A +
Sbjct: 504 GRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQDSAER------AKDLKNITNELL 557
Query: 671 NMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIR 730
+E +R+T + A +PG P+L + + K + L+
Sbjct: 558 RIEPEKTRSTAEGEAFIQA-----------LPGSGTTPLLRTRVEDTNRKYEHLLQLL-- 604
Query: 731 GLEEALRQREREAAAELEAALGKC-EAAEAEAGRLRERVREAEGSGASGGGGGDTTQLRA 789
L Q + + A LE +L + E L + E S G + +
Sbjct: 605 ----DLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMAC 660
Query: 790 ALEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQ-SR 848
L+ + L + + L+ + S+ L ASR +E L +R+EA + + +
Sbjct: 661 ELQAQKSLLGEVEQNLQAAKQCSSTL----ASRF--QEHCPDL-----ERQEAEVHKLGQ 709
Query: 849 ELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEA 908
LR+Q+ + + + A R D + +P+ + L+++
Sbjct: 710 RFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETK--- 766
Query: 909 LRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHE 968
L+ E ++E ++ + +Q V EA +LR+ L+ E S +S+
Sbjct: 767 LKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRA 826
Query: 969 RIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREAL-----FMKSERHAAEAQLATA 1023
R LQ+ +++ + L + EV+ + R+ L + R E ++
Sbjct: 827 R----LQSPATKVKEEEAALAAKF----TEVYAINRQRLQNLEFALNLLRQQPEVEVTHE 878
Query: 1024 EQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNL-----------KEAL 1072
Q + E A + + E ++ ++ + ++ +E++ L KE L
Sbjct: 879 TLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVL 938
Query: 1073 KEQPAA---------------------LATPEVEALRDQVKDLQQQLQEAARDH 1105
K+ P L E+EAL+ Q++ L+Q+ ++ +++
Sbjct: 939 KKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEY 992
Score = 43.5 bits (101), Expect = 0.001
Identities = 179/816 (21%), Positives = 299/816 (36%), Gaps = 148/816 (18%)
Query: 318 DDRDAYEEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQEL--QQLLV 375
+D + E V+ QE LL+K+ + Q+ P+ + +E ++EL Q+ ++
Sbjct: 320 EDYHQFHEDVKDAQE---LLRKV-----DSDLNQKYGPDFKDRYQIELLLRELDDQEKVL 371
Query: 376 ERQEEK----ESLGREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSR 431
++ E+ + G++V L+ R E V L D EGE + L+SR
Sbjct: 372 DKYEDVVQGLQKRGQQVVPLKYR-----RETPLKPIPVEALCDFEGE-------QGLISR 419
Query: 432 QLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIP------ 485
S + Q++ ++ ELM+ ++ A+ VIP
Sbjct: 420 GYSYTLQKN-----------NGESWELMDSAG---------NKLIAPAVCFVIPPTDPEA 459
Query: 486 LALYDSLRAEFDQLRRQHAEALQALRQQET---REVPREEGAACGESEVAGATATKNGPT 542
LAL DSL +++ +R++ A + + L+Q+ E P + G +AG +
Sbjct: 460 LALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDKVASDLD 519
Query: 543 HME--LNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETK 600
E + G + P + A E A D ++ T E E T + A G +
Sbjct: 520 RQEKAITGILRPPLEQGRAVQDSAERAKD--LKNITNELLRIEPEKTRSTAEGEAFIQAL 577
Query: 601 PTGAEVREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAG 660
P + T E+ N + + Q D V+ A
Sbjct: 578 PGSGTTPLLRTRVEDTNRKYEHL-LQLLDLAQEKVDV---------------------AN 615
Query: 661 QAEPPVTGTTNMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAE--AS 718
+ E + + + AT + T ++ V + S G L A E A
Sbjct: 616 RLEKSLQQSWELLATHENHLNQDDTVPESSRVLD----------SKGQELAAMACELQAQ 665
Query: 719 EKLQVELETRIRGLEEA---LRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSG 775
+ L E+E ++ ++ L R +E +LE + LR++V S
Sbjct: 666 KSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSL 725
Query: 776 ASGG--------GGGDTTQLRAALEQAREDLRDRDSRLR-ELEAASACLDEARASRLLAE 826
S G Q ++ D S++ +L+ LDE ASR E
Sbjct: 726 QSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEI-ASR---E 781
Query: 827 EEARGLRAELAQREEARLEQSRELEVLRE--QLATARATGEQQRTAA-AELGRARDAAEA 883
+E + + A Q ++A + E E LR L R++ +R + + ++ A
Sbjct: 782 QEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAA 841
Query: 884 RVAELPAACEEARQGLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVAT 943
A+ RQ L L A LRQ H LQ R R S +E
Sbjct: 842 LAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQ------RNRPDSGVEEAWKI 895
Query: 944 GKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQ 1003
KE L E ER R + + + TL+ +G E + R+ + +V
Sbjct: 896 RKE---LDEETERRRQLENEVKSTQEEIWTLRN-----QGPQESVVRK--EVLKKVPDPV 945
Query: 1004 REALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRA--QEALDKAKEKDKKITEL 1061
E F + +R AE EQ L E A Q Q RA QE D +E
Sbjct: 946 LEESFQQLQRTLAE------EQHKNQLLQEELEALQLQLRALEQETRDGGQE-------- 991
Query: 1062 SKEVFNLKEALKEQPAALATPEVEALRDQVKDLQQQ 1097
+ +KE L+ +P EV LR++++ L++Q
Sbjct: 992 ----YVVKEVLRIEPDRAQADEVLQLREELEALRRQ 1023
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 103 bits (257), Expect = 9e-22
Identities = 168/846 (19%), Positives = 332/846 (39%), Gaps = 89/846 (10%)
Query: 338 QKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESLGREVESLQSRLSL 397
++ + L+ K++ QQ E LE Q++E + + Q EK + +++ L+ +
Sbjct: 929 ERCQHLQAEKKKMQQNIQE------LEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQII 982
Query: 398 LENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSAQEH---LASLQEQVAVLTRQ 454
LE++ + + L+D E E S+ L+ +H + L+E++ +Q
Sbjct: 983 LEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQ 1042
Query: 455 NQELMEKVQILENFEKDETQMEVEALAEVIPLALY-----DSLRAEFDQLRRQHAEALQA 509
QEL + + LE D + E A++ L + + L+A ++ + A+ A
Sbjct: 1043 RQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMA 1102
Query: 510 LRQQETREVPREEGAACGESEVAGATATKNGPTHMELNGSVAPETKVNGAETIDEEAAGD 569
L++ E E ESE A + + G K +T+D AA
Sbjct: 1103 LKKIRELESQISELQEDLESERASRNKAEKQKRDL---GEELEALKTELEDTLDSTAAQQ 1159
Query: 570 ETMEAR---------TMEAEATGAEATGAEAT---GAKVTETKPTGAEVREMETTEEEAN 617
E R T+E EA EA E V E + + ++ E+A
Sbjct: 1160 ELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAK 1219
Query: 618 METKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVT----GTTNME 673
+ + + ++ G K K EA++Q V + E T T ++
Sbjct: 1220 QTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQ 1279
Query: 674 ATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIRGLE 733
TG+ S S + A + L + + ++ L T+++ +E
Sbjct: 1280 VELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQEL----LQEENRQKLSLSTKLKQVE 1335
Query: 734 EALR------QREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGDTTQL 787
+ + E EA LE + A A+ +++++ ++ G L
Sbjct: 1336 DEKNSFREQLEEEEEAKHNLEKQIATLHAQVAD---MKKKMEDSVGC------------L 1380
Query: 788 RAALEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQS 847
A E R+ +D + + E A D+ ++ ++E L +L + ++
Sbjct: 1381 ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLE 1440
Query: 848 RELEVLREQLA--------------TARATGEQQRTAAAELGRARDAAEARVAELPAACE 893
++ + + LA A A ++ T A L RA + A + AEL +
Sbjct: 1441 KKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNK 1500
Query: 894 EARQGLAELREASEALRQSVVPASEHRR-LQEEALELRGRAASLEQEVVATGKEAARLRA 952
+ R + +L + + + +SV + +R L+++ E++ + LE E+ AT RL
Sbjct: 1501 QFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEV 1560
Query: 953 ELER-----ERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREAL 1007
L+ ER + E L V ++E +LE+ ++ A +++ +
Sbjct: 1561 NLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLK 1620
Query: 1008 FMKSERHAAEAQLATAEQQLRGLRTEAERARQ----AQSRAQEALDKAKEKDKKITELSK 1063
+++ +A A +QLR L+ + + + ++ +E L +AKE +KK+ +
Sbjct: 1621 DLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEA 1680
Query: 1064 EVFNLKEALKEQPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQ 1123
E+ L+E L A A + + RD++ D + A +AL L A Q
Sbjct: 1681 EMIQLQEEL--AAAERAKRQAQQERDELAD-----EIANSSGKGALALEEKRRLEARIAQ 1733
Query: 1124 MDEDVQ 1129
++E+++
Sbjct: 1734 LEEELE 1739
Score = 101 bits (251), Expect = 5e-21
Identities = 182/855 (21%), Positives = 327/855 (38%), Gaps = 104/855 (12%)
Query: 333 RGRLLQKIRGLEQ--HKERRQQESPEASSLHI------LERQVQELQQLLVERQEEKESL 384
R RL K + LE+ H + E E H+ +++ +QEL++ L E + ++ L
Sbjct: 903 RARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKL 962
Query: 385 GREVESLQSRLSLLENERE-------NTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSA 437
E + +++L LE E+ + + L+D E E S+ L+
Sbjct: 963 QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLK 1022
Query: 438 QEH---LASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIPLALY----- 489
+H + L+E++ +Q QEL + + LE D + E A++ L +
Sbjct: 1023 NKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKE 1082
Query: 490 DSLRAEFDQLRRQHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTHMELNGS 549
+ L+A ++ + A+ AL++ E E ESE A + + G
Sbjct: 1083 EELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDL---GE 1139
Query: 550 VAPETKVNGAETIDEEAAGDETMEAR---------TMEAEATGAEATGAEAT---GAKVT 597
K +T+D AA E R T+E EA EA E V
Sbjct: 1140 ELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE 1199
Query: 598 ETKPTGAEVREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGV 657
E + + ++ E+A + + + ++ G K K EA++Q V
Sbjct: 1200 ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQV 1259
Query: 658 GAGQAEPPVTG----TTNMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPG 713
+ E T T ++ TG+ S S + A + L
Sbjct: 1260 KFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQEL--- 1316
Query: 714 AAEASEKLQVELETRIRGLE--------------EALRQREREAAA----------ELEA 749
+ + ++ L T+++ +E EA E++ A ++E
Sbjct: 1317 -LQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMED 1375
Query: 750 ALGKCEAAEAEAGRLRERV-----REAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSR 804
++G E AE +L++ + R E A T+L+ L+ DL +
Sbjct: 1376 SVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQS 1435
Query: 805 LRELEAASACLDEARA-----SRLLAEEEARGLRAELAQREEARLEQSRELEVLREQLAT 859
LE D+ A S AEE R AE ++E L +R LE EQ A
Sbjct: 1436 ACNLEKKQKKFDQLLAEEKTISAKYAEERDRA-EAEAREKETKALSLARALEEAMEQKAE 1494
Query: 860 ARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALRQSVVPASEH 919
+Q RT +L ++D V EL + Q + E++ E L + A+E
Sbjct: 1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL-QATED 1553
Query: 920 RRLQEEA----------LELRGRAASLEQEVVATGKEAARLRAELERER----VCSVALS 965
+L+ E +L+GR E++ ++ + AELE ER + A
Sbjct: 1554 AKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARK 1613
Query: 966 EHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQ 1025
+ E + L+A++ +E ++ K A++ RE ++ R AQ E+
Sbjct: 1614 KLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEK 1673
Query: 1026 QLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVE 1085
+L+ + E + ++ + A+ A +A+++ EL+ E+ N ALA E
Sbjct: 1674 KLKSMEAEMIQLQEELAAAERAKRQAQQERD---ELADEIAN-----SSGKGALALEEKR 1725
Query: 1086 ALRDQVKDLQQQLQE 1100
L ++ L+++L+E
Sbjct: 1726 RLEARIAQLEEELEE 1740
Score = 78.6 bits (192), Expect = 3e-14
Identities = 200/906 (22%), Positives = 352/906 (38%), Gaps = 158/906 (17%)
Query: 267 QEAAQRPSPPSALTEDDSGEASSQNSMSSH-GKQGAPKKRKAPPPPASIPMPDDRDAYEE 325
+EAAQ+ + E +S + Q + S + +K+K RD EE
Sbjct: 1094 EEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQK-------------RDLGEE 1140
Query: 326 IVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLL-VERQEEKESL 384
+ L+ E L ++ + +R+QE ++IL++ ++E + + QE ++
Sbjct: 1141 LEALKTELEDTLDSTAAQQELRSKREQE------VNILKKTLEEEAKTHEAQIQEMRQKH 1194
Query: 385 GREVESLQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVLL-----SRQLSPSAQE 439
+ VE L +L + + N TL++E GEL + +VLL S +
Sbjct: 1195 SQAVEELAEQLEQTKRVKANLEKAKQTLENERGELAN--EVKVLLQGKGDSEHKRKKVEA 1252
Query: 440 HLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIPLALYDS----LRAE 495
L LQ + R EL +KV T+++VE L+ DS L +
Sbjct: 1253 QLQELQVKFNEGERVRTELADKV----------TKLQVELDNVTGLLSQSDSKSSKLTKD 1302
Query: 496 FDQLRRQHAEALQALRQQ---------ETREVPREEGA---ACGESEVAGATATKNGPTH 543
F L Q + + L+++ + ++V E+ + E E A K T
Sbjct: 1303 FSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIAT- 1361
Query: 544 MELNGSVAPETKVNGAETIDEEAAGDETMEA--RTMEAEATGAEATGAEATGA--KVTET 599
L+ VA K +++ ET E R ++ + G E A K+ +T
Sbjct: 1362 --LHAQVADMKK-----KMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKT 1414
Query: 600 KPTGAE-----VREMETTEEEA-NMETKPTGAQATDTETTGVEAM-GVEATKTKAEEAEM 652
K + + +++ + A N+E K E + A E + +AE E
Sbjct: 1415 KTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK 1474
Query: 653 QAYGVGAGQA-EPPVTGTTNMEATGSR-ATGMESTGVSATGVENPGVEATVPGISAGPIL 710
+ + +A E + +E + T ME S V G +
Sbjct: 1475 ETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDV--------------GKSV 1520
Query: 711 HP--GAAEASEKLQVELETRIRGLEEALRQREREAAAELEAAL------------GKCEA 756
H + A E+ E++T++ LE+ L+ E +A LE L G+ E
Sbjct: 1521 HELEKSKRALEQQVEEMKTQLEELEDELQATE-DAKLRLEVNLQAMKAQFERDLQGRDEQ 1579
Query: 757 AEAEAGRLRERVREAEGS------------GASGGGGGDTTQLRAALEQAREDLRDRDSR 804
+E + +L +VRE E A D L A ++ A ++ + +
Sbjct: 1580 SEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQ 1639
Query: 805 LRELEAASA-C---LDEARASR--LLA-----EEEARGLRAELAQREE---ARLEQSREL 850
LR+L+A C LD+ RASR +LA E++ + + AE+ Q +E A R+
Sbjct: 1640 LRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQA 1699
Query: 851 EVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREASEALR 910
+ R++LA A + A E R EAR+A+L EE + + + +
Sbjct: 1700 QQERDELADEIANSSGKGALALEEKRR---LEARIAQLEEELEEEQGNTELINDRLKKAN 1756
Query: 911 QSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHERI 970
+ + L+ + A Q++ KE E+E S+++
Sbjct: 1757 LQIDQINTDLNLERSHAQKNENA---RQQLERQNKELKVKLQEME-----GTVKSKYKAS 1808
Query: 971 VGTLQANVAQLEGQLE-----------ELGRRHEKTSAEVFQV---QREALFMKSERHAA 1016
+ L+A +AQLE QL+ ++ R +K + QV +R A K + A
Sbjct: 1809 ITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKA 1868
Query: 1017 EAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQP 1076
+L ++QL EA+RA ++ + Q L+ A E +++EV +LK L+
Sbjct: 1869 STRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATE---TADAMNREVSSLKNKLRRGD 1925
Query: 1077 AALATP 1082
P
Sbjct: 1926 LPFVVP 1931
Score = 71.6 bits (174), Expect = 4e-12
Identities = 93/430 (21%), Positives = 175/430 (40%), Gaps = 48/430 (11%)
Query: 724 ELETRIRGLEEALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGD 783
EL R+ ++ L + + A +E +C+ +AE ++++ ++E E
Sbjct: 901 ELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQ 960
Query: 784 TTQLRAA--------LEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAE 835
QL LE+ + L D++ +L + + + L EEE A+
Sbjct: 961 KLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAK 1020
Query: 836 LAQREEARL----EQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAA 891
L + EA + E+ R E R++L R E T +L +A++AEL
Sbjct: 1021 LKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDST---DLSDQIAELQAQIAELKMQ 1077
Query: 892 C----EEARQGLAELREASE----ALRQSVVPASEHRRLQEEALELRGRAASLEQEVVAT 943
EE + LA + E + AL++ S+ LQE+ R E++
Sbjct: 1078 LAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDL 1137
Query: 944 GKEAARLRAELE--------RERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKT 995
G+E L+ ELE ++ + S E + TL+ E Q++E+ ++H +
Sbjct: 1138 GEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQA 1197
Query: 996 SAEVFQVQREALFMKSERHAAEAQLATAEQQ--------LRGLRTEAERARQAQSRAQEA 1047
E+ + + +K+ A+ L + L+G + ++ +++ QE
Sbjct: 1198 VEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQEL 1257
Query: 1048 LDKAKEKDKKITELSKEVFNLKEAL---------KEQPAALATPEVEALRDQVKDLQQQL 1098
K E ++ TEL+ +V L+ L + ++ T + AL Q++D Q+ L
Sbjct: 1258 QVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELL 1317
Query: 1099 QEAARDHSSV 1108
QE R S+
Sbjct: 1318 QEENRQKLSL 1327
Score = 65.9 bits (159), Expect = 2e-10
Identities = 94/397 (23%), Positives = 169/397 (42%), Gaps = 81/397 (20%)
Query: 791 LEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQSREL 850
L + RE ++RL E+E S+L+AE + +L ++ +A E E
Sbjct: 854 LVKVREKQLAAENRLTEMETLQ--------SQLMAE------KLQLQEQLQAETELCAEA 899
Query: 851 EVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEAR----------QGLA 900
E LR AR T ++Q EL EARV E C+ + Q L
Sbjct: 900 EELR-----ARLTAKKQ-----ELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELE 949
Query: 901 ELREASEALRQ-----SVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELE 955
E E E+ RQ V ++ ++L+EE + L + L +E A L
Sbjct: 950 EQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLT 1009
Query: 956 RERVCSVAL----SEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKS 1011
E S +L ++HE ++ L+ + + E Q +EL + K + + + +++
Sbjct: 1010 EEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQA 1069
Query: 1012 ERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQE--ALDKAKEKDKKITELSKEVFNLK 1069
+ + QLA E++L +A AR + AQ+ AL K +E + +I+EL +++ + +
Sbjct: 1070 QIAELKMQLAKKEEEL-----QAALARVEEEAAQKNMALKKIRELESQISELQEDLESER 1124
Query: 1070 -----------------EALKEQ-----PAALATPEVEALRDQ-VKDLQQQLQEAARDHS 1106
EALK + + A E+ + R+Q V L++ L+E A+ H
Sbjct: 1125 ASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE 1184
Query: 1107 SVVALYRSHLLYAIQGQMDEDVQRILSQILQMQRLQA 1143
+ + R + + V+ + Q+ Q +R++A
Sbjct: 1185 AQIQEMRQ--------KHSQAVEELAEQLEQTKRVKA 1213
Score = 51.6 bits (122), Expect = 4e-06
Identities = 66/291 (22%), Positives = 130/291 (44%), Gaps = 25/291 (8%)
Query: 835 ELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEE 894
+++++EE + + EL +RE+ A + T ++L + + ++ C E
Sbjct: 839 QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898
Query: 895 ARQGLA-------ELREASEALRQSVVPASEH-RRLQEEALELRGRAASLEQEVVATGKE 946
A + A EL E L V E + LQ E +++ LE+++ +E
Sbjct: 899 AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQL--EEEE 956
Query: 947 AARLRAELERERV-CSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQRE 1005
+AR + +LE+ + E E+I+ L+ +L + + L R + + + + + +
Sbjct: 957 SARQKLQLEKVTTEAKLKKLEEEQII--LEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK 1014
Query: 1006 ALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEV 1065
+ + ++ EA + E++LR R E +R ++R + D D +I EL ++
Sbjct: 1015 SKSLAKLKNKHEAMITDLEERLR--REEKQRQELEKTRRKLEGDSTDLSD-QIAELQAQI 1071
Query: 1066 FNLKEAL----KEQPAALATPEVEALR-----DQVKDLQQQLQEAARDHSS 1107
LK L +E AALA E EA + ++++L+ Q+ E D S
Sbjct: 1072 AELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLES 1122
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 102 bits (254), Expect = 2e-21
Identities = 206/827 (24%), Positives = 342/827 (41%), Gaps = 108/827 (13%)
Query: 330 RQERGRLLQKIRGLEQHKER-RQQESPEASSLHILERQVQEL-QQLLVERQEEKESLGRE 387
++++ +L Q ++ EQ + R Q +SSL E+Q++E+ ++ RQ+ + L
Sbjct: 529 KEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATA 588
Query: 388 VESLQSRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSAQEHLASLQEQ 447
E ++ L ER+ + L+ E+ ++ ++ ++ + SAQ + Q +
Sbjct: 589 AEEREASL----RERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQRE 644
Query: 448 VAVLTRQNQELMEKVQILENFEKDETQ-----MEVEALAEVIPLALYDSLRAEFDQLRRQ 502
A L+R+ +EL V+ E+ E Q +E++ +E + + E DQL+ Q
Sbjct: 645 KAELSRKVEELQACVETARQ-EQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQ 703
Query: 503 HAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTHMELNGSVAP--ETKVNGAE 560
LQAL++ + +G+ E A + EL E +
Sbjct: 704 ----LQALKE----SLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERK 755
Query: 561 TIDEEAAGDETMEARTME-AEATGAEATG-----AEATGAKVT---ETKPTGAEVREMET 611
++EE AG + +EAR + EA AE AEA A+ T E + EV
Sbjct: 756 ELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRE 815
Query: 612 TEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAEPPVTGTTN 671
E++ E GA + T E E + + +EA+ + G+ +E ++ N
Sbjct: 816 RYEDSQQEEAQYGAMFQEQLMTLKEE--CEKARQELQEAKEKVAGI-ESHSELQISRQQN 872
Query: 672 --MEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRI 729
E + A ++ V+ V A + AA + E LET +
Sbjct: 873 ELAELHANLARALQQ-------VQEKEVRAQKLADDLSTLQEKMAATSKE--VARLETLV 923
Query: 730 RGLEEALRQREREAAAE-LEAALGKCEAAEAEAGR--------LRERVREAEGSGASGGG 780
R E RE E A + E E + GR L+ REAE
Sbjct: 924 RKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQM------ 977
Query: 781 GGDTTQLRAALEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQR- 839
G + +LRAAL +++ ++ + +E E A + RA LA E+A RAEL R
Sbjct: 978 GNELERLRAALMESQGQQQEERGQ-QEREVARLTQERGRAQADLALEKA--ARAELEMRL 1034
Query: 840 EEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGL 899
+ A EQ E L+E LA A E + EL + R A++ EL EE RQ +
Sbjct: 1035 QNALNEQRVEFATLQEALAHALTEKEGK---DQELAKLRGLEAAQIKEL----EELRQTV 1087
Query: 900 AELRE---------ASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARL 950
+L+E AS + QS A + LR + LEQ+ ++A L
Sbjct: 1088 KQLKEQLAKKEKEHASGSGAQSEA-AGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSL 1146
Query: 951 RAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMK 1010
LE ER + +E + + TLQ QLE + +ELG H +++ Q + A K
Sbjct: 1147 ERSLEAER---ASRAERDSALETLQ---GQLEEKAQELG--HSQSALASAQRELAAFRTK 1198
Query: 1011 SERHAAEAQLATAEQQLRGLRTEAERARQAQSRAQEALD----KAKEKDKKITELSK--- 1063
+ H ++A+ Q RG R EAER S +E + + EK+ + EL +
Sbjct: 1199 VQDH-SKAEDEWKAQVARG-RQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVM 1256
Query: 1064 ----------EVFNLKEALKEQPAALATPEVEALRDQVKDLQQQLQE 1100
E L +A +A A ALR++V+ L+++ ++
Sbjct: 1257 AESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEK 1303
Score = 97.4 bits (241), Expect = 7e-20
Identities = 210/921 (22%), Positives = 359/921 (38%), Gaps = 169/921 (18%)
Query: 316 MPDDRDAYEEI-VRLRQERGRLLQK---IRGLEQHKERRQQESPEASSLHILERQVQELQ 371
+ D+R +E+ + L + R L +K I ++Q +R + + ++ + ++++EL+
Sbjct: 223 LADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELR 282
Query: 372 QLLVERQEEKESLGREVESLQSRLSLLENERENTSYDVTTLQDEEGE-----------LP 420
++ ESL + + L+ E+ + L +E G+ L
Sbjct: 283 -------DKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQ 335
Query: 421 DLPGAEVLLSRQLSPSAQEHL---ASLQEQVAVLTRQNQELMEKVQILE----------- 466
L A L+ + S + QE L A L+++++ + + L EK +IL+
Sbjct: 336 QLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLS 395
Query: 467 NFEKDETQMEVEALAEVIPLALYD----SLRAEFDQLRRQHAEALQALRQQETREVPREE 522
+ + Q + E L +V+ L +L A QL+ + E L+ R Q+ ++ E
Sbjct: 396 QLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQAR-VEMLETERGQQEAKLLAER 454
Query: 523 GAACGESEVAGATATKNGPTHMELNGSVAPETKVNGAETIDEEAAGDE-TMEARTMEAEA 581
G E + + T +L S++ ++ +A G T + ++ +E
Sbjct: 455 GHFEEEKQQLSSLIT-------DLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSEL 507
Query: 582 TGAEAT----GAEATGAKVTETKPTGAEVREMETTEEEANMETKPTGAQ----------- 626
T AT E G K + K A++ + +E+A+ + Q
Sbjct: 508 TTLNATIQQQDQELAGLK-QQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQ 566
Query: 627 ----ATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAGQAE-------PPVTGTTNMEAT 675
A E T + AT + EA ++ Q E +
Sbjct: 567 LKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQV 626
Query: 676 GSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQVELETRIRGLEEA 735
+ A T V+ E + V + A E + + Q E + ++ LE
Sbjct: 627 ANEARDSAQTSVTQAQREKAELSRKVEELQA-------CVETARQEQHEAQAQVAELELQ 679
Query: 736 LRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGDTTQLRAALEQAR 795
LR E++ A E E + + + + L+E ++ +GS L +A
Sbjct: 680 LRS-EQQKATEKERVAQEKDQLQEQLQALKESLKVTKGS------------LEEEKRRAA 726
Query: 796 EDLRDRDSRLRELEAASACLDE--ARASRLLAEEEA--RGLRAELAQREEARLEQSRELE 851
+ L ++ + EL+A + L E R + L EE A +GL A L Q EA E E
Sbjct: 727 DALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEA---HQAETE 783
Query: 852 VLREQLATARA---TGEQQ-----RTAAAELGRARDAA----------EARVAELPAACE 893
VLR +LA A A T E + + AA R D+ + ++ L CE
Sbjct: 784 VLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECE 843
Query: 894 EARQGLAELREASEAL---------RQSVVPASEH----RRLQE------EALELRGRAA 934
+ARQ L E +E + RQ A H R LQ+ A +L +
Sbjct: 844 KARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLS 903
Query: 935 SLEQEVVATGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEK 994
+L++++ AT KE ARL L R+ + E + +A Q E E+ GR+
Sbjct: 904 TLQEKMAATSKEVARLET-LVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCS 962
Query: 995 TSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAER--ARQAQSRAQEALDKAK 1052
T A + ++REA M +E A L ++ Q + R + ER AR Q R + D A
Sbjct: 963 TQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLAL 1022
Query: 1053 EK----------DKKITELSKEVFNLKEAL---------KEQP-------AALATPEVEA 1086
EK + E E L+EAL K+Q A E+E
Sbjct: 1023 EKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEE 1082
Query: 1087 LRDQVKDLQQQLQEAARDHSS 1107
LR VK L++QL + ++H+S
Sbjct: 1083 LRQTVKQLKEQLAKKEKEHAS 1103
Score = 94.7 bits (234), Expect = 4e-19
Identities = 196/889 (22%), Positives = 343/889 (38%), Gaps = 122/889 (13%)
Query: 324 EEIVRLRQERGRLLQKIRGLEQHKERR-QQESPEASSLHI-LERQVQELQQLLVERQ--- 378
EE + RQE +K+ G+E H E + ++ E + LH L R +Q++Q+ V Q
Sbjct: 840 EECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLA 899
Query: 379 -------EEKESLGREVESLQSRLSLLENERENTSYDVTTLQDEEGE-----LPDLPGAE 426
E+ + +EV L++ + ++E S ++ G+ L + G +
Sbjct: 900 DDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQ 959
Query: 427 VLLSRQLSPSAQEHLASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIPL 486
S Q + A E A ++ L R LME Q + E+ + + EV L +
Sbjct: 960 -FCSTQAALQAMEREA--EQMGNELERLRAALMES-QGQQQEERGQQEREVARLTQ---- 1011
Query: 487 ALYDSLRAEFDQLRRQHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTH--M 544
+ RA+ D + A A +R Q R E A E+ +A A K G
Sbjct: 1012 ---ERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEA-LAHALTEKEGKDQELA 1067
Query: 545 ELNGSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGA 604
+L G A + K ++E + ++ + + E A +GA++ A TE
Sbjct: 1068 KLRGLEAAQIK-----ELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKL 1122
Query: 605 EVREMETTEEEANMETKPTGAQATDTETTGVEAMGVE---ATKTKAEEAEMQAYGVGAGQ 661
E E ++ E + + A + + A E A +T + E +A +G Q
Sbjct: 1123 EALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQ 1182
Query: 662 -----AEPPVTGTTNMEATGSRATGMESTGVSATGVENP-------GVEATVPGISAGPI 709
A+ + S+A V+ E +E V ++ +
Sbjct: 1183 SALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVL 1242
Query: 710 LHPGAAEASEKLQVELETRIRGLEEALRQREREAAAELEAALGKCEAAEAEAGRLRERVR 769
G ++ ++L + + + LEE LR + E A+ A + A E LRE
Sbjct: 1243 EKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAE 1302
Query: 770 EAEGSGASGGGGGDTTQLRAALEQAREDLRDRDSRLRELEAASACLD------EARASRL 823
+ AS + T E+ ++L+ + + E A + L +A S L
Sbjct: 1303 KQRV--ASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSEL 1360
Query: 824 L-AEEEARGLRAELA---QREEARLEQSREL------EVLREQ------LATARATGEQQ 867
L A+ + L+AE A +R LEQS++ E+LR Q + + EQ+
Sbjct: 1361 LPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQE 1420
Query: 868 RTAAAELGRARDAAE--ARVAELPAACEEARQGLAELREASEALRQSVVPASEHRRLQEE 925
RTA AE + + + E +GL E + + + + +QE
Sbjct: 1421 RTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQEL 1480
Query: 926 AL---ELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLE 982
A + R A +++E +T +E + A+ E +V L E +R Q AQ+E
Sbjct: 1481 AAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKV--KVLEERQRFQEERQKLTAQVE 1538
Query: 983 G----------QLEELGRRH--------------EKTSAEVFQVQREALFMKSERHAAEA 1018
Q+EEL ++ + A+ + Q+EA ++++ + +A
Sbjct: 1539 QLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQA 1598
Query: 1019 QLATAEQ-------QLRGLRTEAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEA 1071
QL+ EQ Q+ +T + +Q QE L ++ K+ EL E L
Sbjct: 1599 QLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHE 1658
Query: 1072 LK---------EQPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVAL 1111
L+ EQ T +V +L QV QQL++ + + AL
Sbjct: 1659 LQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDAL 1707
Score = 94.4 bits (233), Expect = 6e-19
Identities = 161/775 (20%), Positives = 306/775 (39%), Gaps = 75/775 (9%)
Query: 325 EIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKESL 384
E+ RL QERGR Q LE+ R + E ++L+ + LQ+ L EKE
Sbjct: 1005 EVARLTQERGRA-QADLALEK-AARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGK 1062
Query: 385 GREVESLQ----SRLSLLENERENTSYDVTTLQDEEGELPDLPGAEVLLSRQLSPSAQEH 440
+E+ L+ +++ LE R+ L +E E GA+ + + P+ +
Sbjct: 1063 DQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPK- 1121
Query: 441 LASLQEQVAVLTRQNQELMEKVQILENFEKDETQMEVEALAEVIPLALYDSLRAEFDQLR 500
L +L+ +V+ L +Q Q+ E+ LE +E E + + ++L+ + ++
Sbjct: 1122 LEALRAEVSKLEQQCQKQQEQADSLER------SLEAERASRAERDSALETLQGQLEEKA 1175
Query: 501 RQ--HAEALQALRQQET---REVPREEGAACGESEVAGATATKNGPTHMELNGSVAPETK 555
++ H+++ A Q+E R ++ A E + A + L S+ E
Sbjct: 1176 QELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVS 1235
Query: 556 VNGAETIDEEAAGDETMEA---------------RTMEAEATGAEATGAEATGAKVTETK 600
+ + +++E E R ++AE A AE + A E +
Sbjct: 1236 ILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQ 1295
Query: 601 PTGAEVREMETTEEEANMETKPTGAQATDTETTGVEAMGVEATKTKAEEAEMQAYGVGAG 660
E + E E +QA E G E + + E+A
Sbjct: 1296 SLREEAEKQRVASENLRQELT---SQAERAEELGQELKAWQEKFFQKEQA---------- 1342
Query: 661 QAEPPVTGTTNMEATGSRATGMESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEK 720
T +E T ++A E + +A + + +A+
Sbjct: 1343 ------LSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQ--SKQAAGG 1394
Query: 721 LQVELETRIRGLEEALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGG 780
L+ EL R L E + R++ AE E + A +A +++A G A
Sbjct: 1395 LRAELLRAQRELGELIPLRQK--VAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENR 1452
Query: 781 G-GDTTQLRAALEQAREDLRDRDSRLRELEAASACLDEARAS-RLLAEEEARGLRAELAQ 838
G G+ L + D + R+ ++EL A A + A + A+ AR L A+
Sbjct: 1453 GLGERANLGRQFLEVELD-QAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAK 1511
Query: 839 REEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQG 898
E A+++ E + +E+ A EQ E + + ++A+ A + +Q
Sbjct: 1512 YEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQK 1571
Query: 899 LAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERER 958
L ++ +Q E +RLQ + EL+ + + EQ + + + + ++
Sbjct: 1572 LKAVQAQGGESQQ------EAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKK 1625
Query: 959 VCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEA 1018
+ L E R + LQ +L + E LG ++ + + ++ + ++ + EA
Sbjct: 1626 QQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEA 1685
Query: 1019 QLATAEQQLRGL-----RTEAERARQAQSRAQ-----EALDKAKEKDKKITELSK 1063
Q+A A+QQLR L T+A ++R+ Q++ Q ++LD + E+ ++ SK
Sbjct: 1686 QVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSK 1740
Score = 92.8 bits (229), Expect = 2e-18
Identities = 203/886 (22%), Positives = 337/886 (38%), Gaps = 173/886 (19%)
Query: 324 EEIVRLRQERGRLLQKIRGLEQHKERRQQESPEASSLHILERQVQELQQLLVERQEEKES 383
+E L +L ++ LE ER QQE+ + E + Q+L L+ + Q +
Sbjct: 420 QEAATLAANNTQLQARVEMLET--ERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISN 477
Query: 384 LGREVESL----QSRLSLLENERENTSYDVTTL----QDEEGELPDL------PGAEVLL 429
L + E L Q+ + L + + + ++TTL Q ++ EL L A++
Sbjct: 478 LSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQ 537
Query: 430 SRQLSPSAQEHLASLQEQV-AVLTRQNQELMEKVQILENFEKDETQMEVEALAE-VIPLA 487
+ Q A + L EQ+ + L ++ Q+L E + E +D Q A E L
Sbjct: 538 TLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLR 597
Query: 488 LYDSLRAEFDQLRRQHAEALQALRQQETREVPREEGAACGESEVAGATATKNGPTHMELN 547
D+ + + L ++ A L+ L+QQ E+ + T+
Sbjct: 598 ERDAALKQLEALEKEKAAKLEILQQQL---------QVANEARDSAQTSV---------- 638
Query: 548 GSVAPETKVNGAETIDEEAAGDETMEARTMEAEATGAEATGAEATGAKVTETKPTGAEVR 607
+ A K + ++E A ET EA+A AE
Sbjct: 639 -TQAQREKAELSRKVEELQACVETARQEQHEAQAQVAEL--------------------- 676
Query: 608 EMETTEEEANMETKPTGAQATDTETTGVEAM--GVEATKTKAEEAEMQAYGVGAGQAEPP 665
E++ E+ K AQ D ++A+ ++ TK EE + +A A E
Sbjct: 677 ELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRA----ADALEEQ 732
Query: 666 VTGTTNMEATGSRATGM---ESTGVSATGVENPGVEATVPGISAGPILHPGAAEASEKLQ 722
+ ++A E + G+EA + + G A +E
Sbjct: 733 QRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQL--------GEAHQAE--- 781
Query: 723 VELETRIRGLEEALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGG-- 780
E LR+ EA A A +CE E RER +++ A G
Sbjct: 782 ----------TEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMF 831
Query: 781 GGDTTQLRAALEQAREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRA-ELAQR 839
L+ E+AR++L++ ++ +E+ S L +R LAE A RA + Q
Sbjct: 832 QEQLMTLKEECEKARQELQEAKEKVAGIESHSE-LQISRQQNELAELHANLARALQQVQE 890
Query: 840 EEARLEQ-SRELEVLREQLAT-----------ARATGEQQRTAAAEL----GRARDAAE- 882
+E R ++ + +L L+E++A R GEQQ TA+ EL RA D
Sbjct: 891 KEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPE 950
Query: 883 -----------ARVAELPAACEEARQGLAELREASEALRQSVVPASEHRRLQEEAL---- 927
+ A L A EA Q EL AL +S E R QE +
Sbjct: 951 WLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLT 1010
Query: 928 ELRGRA-ASLEQEVVATGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLE 986
+ RGRA A L E A + RL+ L +RV L E L + + EG+ +
Sbjct: 1011 QERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQE------ALAHALTEKEGKDQ 1064
Query: 987 ELGRRHEKTSAEVFQVQ---------REALFMKSERHA----AEAQLATAEQ----QLRG 1029
EL + +A++ +++ +E L K + HA A+++ A + +L
Sbjct: 1065 ELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEA 1124
Query: 1030 LRTEAERARQAQSRAQEALDKAK-----------EKDKKITELSKEVFNLKEALKEQPAA 1078
LR E + Q + QE D + E+D + L ++ + L +A
Sbjct: 1125 LRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSA 1184
Query: 1079 LATP--EVEALRDQVKD-----------LQQQLQEAARDHSSVVAL 1111
LA+ E+ A R +V+D + + QEA R +S + +L
Sbjct: 1185 LASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSL 1230
Score = 87.8 bits (216), Expect = 5e-17
Identities = 105/448 (23%), Positives = 189/448 (42%), Gaps = 85/448 (18%)
Query: 725 LETRIRGLEEALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGDT 784
L + + L ++Q+++E A G + A+ + +L + +++ E AS G
Sbjct: 503 LTSELTTLNATIQQQDQELA-------GLKQQAKEKQAQLAQTLQQQEQ--ASQG----- 548
Query: 785 TQLRAALEQAREDLRDRDSRLRELEAASACLDEARASRLL--AEEEARGLR---AELAQR 839
LR +EQ L+ ++ +L+E+ + A +L AEE LR A L Q
Sbjct: 549 --LRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQL 606
Query: 840 EEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQ-- 897
E E++ +LE+L++QL A + +T+ + R + +V EL A E ARQ
Sbjct: 607 EALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQ 666
Query: 898 --GLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELE 955
A++ E LR A+E R+ +E +L+ + +L++ + T + LE
Sbjct: 667 HEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVT-------KGSLE 719
Query: 956 RE-RVCSVALSEHERIVGTLQANVAQ---------------------LEGQLEELGRRHE 993
E R + AL E +R + L+A LE +L++LG H+
Sbjct: 720 EEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQ 779
Query: 994 KTSAEVFQVQREALFMKSERHAAEAQL-------------------------ATAEQQLR 1028
AE ++RE + +H AE++ A ++QL
Sbjct: 780 ---AETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLM 836
Query: 1029 GLRTEAERARQAQSRAQEALDKAK-EKDKKITELSKEVFNLKEALKEQPAALATPEVEA- 1086
L+ E E+ARQ A+E + + + +I+ E+ L L + EV A
Sbjct: 837 TLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQ 896
Query: 1087 -LRDQVKDLQQQLQEAARDHSSVVALYR 1113
L D + LQ+++ +++ + + L R
Sbjct: 897 KLADDLSTLQEKMAATSKEVARLETLVR 924
Score = 85.9 bits (211), Expect = 2e-16
Identities = 108/414 (26%), Positives = 176/414 (42%), Gaps = 57/414 (13%)
Query: 734 EALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASGGGGGDTTQLRAALEQ 793
E L+Q AA + E E E G+ +EA+ G + QL + +
Sbjct: 416 ETLKQEAATLAANNTQLQARVEMLETERGQ-----QEAKLLAERGHFEEEKQQLSSLITD 470
Query: 794 AREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQSRELEVL 853
+ + + ELE AS +A +RL A+ L +EL +Q +EL L
Sbjct: 471 LQSSISNLSQAKEELEQAS----QAHGARLTAQ--VASLTSELTTLNATIQQQDQELAGL 524
Query: 854 REQLATARATGEQQRTAAAELGRARDAAEA---RVAELPAACEEARQGLAELREASEALR 910
++Q E+Q A L + A++ +V +L ++ ++ Q L E+ E EA R
Sbjct: 525 KQQAK------EKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR 578
Query: 911 QSVVPASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELERERVCSVALSEHERI 970
Q + EA LR R A+L+Q ++AA+L ++ +V + A
Sbjct: 579 QDHAQQLATAAEEREA-SLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARD----- 632
Query: 971 VGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGL 1030
+ Q +V Q + + EL R+ E+ A V ++E +H A+AQ+A E QLR
Sbjct: 633 --SAQTSVTQAQREKAELSRKVEELQACVETARQE-------QHEAQAQVAELELQLRSE 683
Query: 1031 R---TEAERARQAQSRAQEALDKAKEKDKKITE--LSKEVFNLKEALKEQPAALAT---- 1081
+ TE ER Q + + QE L KE K+T+ L +E +AL+EQ ++
Sbjct: 684 QQKATEKERVAQEKDQLQEQLQALKES-LKVTKGSLEEEKRRAADALEEQQRCISELKAE 742
Query: 1082 ------------PEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLLYAIQGQ 1123
E+E R K L+ +LQ+ H + + R L A+ Q
Sbjct: 743 TRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQ 796
Score = 70.1 bits (170), Expect = 1e-11
Identities = 97/417 (23%), Positives = 179/417 (42%), Gaps = 36/417 (8%)
Query: 722 QVELETRIRGLEEALRQRER----EAAAELEAALGKCEAAEAEAGRLRERVREA-EGSGA 776
+VE+ RG +EA ER E +L + + +++ + + +E + +A + GA
Sbjct: 435 RVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGA 494
Query: 777 S-----GGGGGDTTQLRAALEQAREDLRDRDSRLRELEA--ASACLDEARASRLLAEEEA 829
+ T L A ++Q ++L + +E +A A + +AS+ L +
Sbjct: 495 RLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGL-RHQV 553
Query: 830 RGLRAELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAA----EARV 885
L + L Q+E+ E + + E R+ A AT ++R A+ R RDAA EA
Sbjct: 554 EQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASL---RERDAALKQLEALE 610
Query: 886 AELPAACEEARQGLAELREASEALRQSVVPAS-EHRRLQEEALELRGRAASLEQEVVATG 944
E A E +Q L EA ++ + SV A E L + EL+ + QE
Sbjct: 611 KEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQ 670
Query: 945 KEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQVQR 1004
+ A L +L E+ + +E ER+ QL+ QL+ L + T + + +R
Sbjct: 671 AQVAELELQLRSEQQKA---TEKERVAQEKD----QLQEQLQALKESLKVTKGSLEEEKR 723
Query: 1005 EALFMKSERHAA----EAQLATAEQQLRGLRTEAERARQAQSRAQEALDKAKEKDKKITE 1060
A E+ +A+ + +Q + R E E R + + L + E + TE
Sbjct: 724 RAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETE 783
Query: 1061 LSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQQQLQEAARDHSSVVALYRSHLL 1117
+ + L EA+ Q A E E L +V +++ +++ ++ + A+++ L+
Sbjct: 784 VLRR--ELAEAMAAQHT--AESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLM 836
Score = 69.7 bits (169), Expect = 1e-11
Identities = 101/462 (21%), Positives = 185/462 (40%), Gaps = 61/462 (13%)
Query: 734 EALRQREREAAAELEAALGKCEAAEAEAGRLRERVRE-AEGSGASGGGGGDTTQLRAALE 792
E LR + L L +C+ + E ++ ++ + +E +G + L+
Sbjct: 279 EELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQ 338
Query: 793 QAREDLRDRDSRL------------RELEAA---SACLDE------ARASRLLAEEEARG 831
A +L + S+ +EL AA CL+E + S+L EE
Sbjct: 339 DALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQL--EEHLSQ 396
Query: 832 LRAELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAELPAA 891
L+ Q + L +LE L+++ AT A Q + L R EA++
Sbjct: 397 LQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGH 456
Query: 892 CEEARQ-----------GLAELREASEALRQSVVPASEHRRLQEEALELRGRAASLEQEV 940
EE +Q ++ L +A E L Q+ + RL + L +L +
Sbjct: 457 FEEEKQQLSSLITDLQSSISNLSQAKEELEQA--SQAHGARLTAQVASLTSELTTLNATI 514
Query: 941 VATGKEAARLRAEL-ERERVCSVALSEHERI-------VGTLQANVAQLEGQLEELGRRH 992
+E A L+ + E++ + L + E+ V L +++ Q E QL+E+ +
Sbjct: 515 QQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQ 574
Query: 993 EKTSAEVFQ------VQREALFMKSERHAAEAQLATAEQQ----LRGLRTEAERARQAQS 1042
E T + Q +REA ER AA QL E++ L L+ + + A +A+
Sbjct: 575 EATRQDHAQQLATAAEEREASL--RERDAALKQLEALEKEKAAKLEILQQQLQVANEARD 632
Query: 1043 RAQEALDKAK----EKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQQQL 1098
AQ ++ +A+ E +K+ EL V ++ E A +A E++ +Q K +++
Sbjct: 633 SAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKER 692
Query: 1099 QEAARDHSSVVALYRSHLLYAIQGQMDEDVQRILSQILQMQR 1140
+D L +G ++E+ +R + + QR
Sbjct: 693 VAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQR 734
Score = 43.1 bits (100), Expect = 0.002
Identities = 44/232 (18%), Positives = 102/232 (43%), Gaps = 24/232 (10%)
Query: 915 PASEHRRLQEEALELRGRAASLEQEVVATGKEAARLRAELE--RERVCSVALSEHERIVG 972
P + RRL+++ + R LE E+ K A++ ++R+ +AL ++
Sbjct: 212 PQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAAS 271
Query: 973 TLQANVAQLEGQLEELGRRHEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRT 1032
L+ +LEEL ++E + + + ++ +K+E+ + ++ ++ L
Sbjct: 272 PLEPK------ELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSF 325
Query: 1033 EAERARQAQSRAQEALDKAKEKDKKITELSKEVFNLKEALKEQPAALATPEVEALRDQVK 1092
+ + Q+AL++ E+ K T+ E K+A E+ + A + + L ++ +
Sbjct: 326 KLREFASHLQQLQDALNELTEEHSKATQEWLE----KQAQLEKELSAALQDKKCLEEKNE 381
Query: 1093 DLQQQLQEAARDHSSVVALYRSHLLYAIQGQMDEDVQRILSQILQMQRLQAQ 1144
LQ +L + +H L +Q ++ +L +LQ++ L+ +
Sbjct: 382 ILQGKLSQ-LEEH-----------LSQLQDNPPQEKGEVLGDVLQLETLKQE 421
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.125 0.335
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,195,424
Number of Sequences: 37866
Number of extensions: 1973864
Number of successful extensions: 29601
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 587
Number of HSP's successfully gapped in prelim test: 1273
Number of HSP's that attempted gapping in prelim test: 12703
Number of HSP's gapped (non-prelim): 9634
length of query: 1146
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1033
effective length of database: 13,968,660
effective search space: 14429625780
effective search space used: 14429625780
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.