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Search of human proteins with 41327732
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41327732 epidermal growth factor receptor isoform b
precursor [Homo sapiens]
(628 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41327732 epidermal growth factor receptor isoform b precursor... 1335 0.0
gi|29725609 epidermal growth factor receptor isoform a precursor... 1334 0.0
gi|41327736 epidermal growth factor receptor isoform d precursor... 1334 0.0
gi|41327734 epidermal growth factor receptor isoform c precursor... 847 0.0
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo... 631 0.0
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo... 631 0.0
gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens] 591 e-169
gi|54792096 erbB-2 isoform a [Homo sapiens] 580 e-165
gi|54792098 erbB-2 isoform b [Homo sapiens] 568 e-162
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 133 6e-31
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 133 6e-31
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 109 9e-24
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 108 1e-23
gi|54792102 erbB-3 isoform s precursor [Homo sapiens] 106 6e-23
gi|20336184 paired basic amino acid cleaving system 4 isoform h ... 61 4e-09
gi|20336182 paired basic amino acid cleaving system 4 isoform g ... 61 4e-09
gi|4505577 paired basic amino acid cleaving system 4 isoform a p... 61 4e-09
gi|20336180 paired basic amino acid cleaving system 4 isoform b ... 61 4e-09
gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo ... 59 1e-08
gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo ... 59 1e-08
gi|239755070 PREDICTED: similar to proprotein convertase subtili... 55 2e-07
gi|20336246 proprotein convertase subtilisin/kexin type 5 prepro... 55 3e-07
gi|108773804 Fraser syndrome 1 [Homo sapiens] 54 4e-07
gi|122937343 platelet endothelial aggregation receptor 1 [Homo s... 42 0.002
gi|28626521 zinc finger, NFX1-type containing 1 [Homo sapiens] 40 0.005
gi|33598931 scavenger receptor class F, member 1 isoform 3 precu... 37 0.042
gi|33598929 scavenger receptor class F, member 1 isoform 1 precu... 37 0.042
gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens] 37 0.042
gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens] 37 0.042
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 37 0.042
>gi|41327732 epidermal growth factor receptor isoform b precursor
[Homo sapiens]
Length = 628
Score = 1335 bits (3456), Expect = 0.0
Identities = 628/628 (100%), Positives = 628/628 (100%)
Query: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
Sbjct: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
Query: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
Sbjct: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
Query: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
Sbjct: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
Query: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
Sbjct: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
Query: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
Sbjct: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
Query: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
Sbjct: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
Query: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF 420
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
Sbjct: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF 420
Query: 421 ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL 480
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
Sbjct: 421 ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL 480
Query: 481 FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN 540
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
Sbjct: 481 FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN 540
Query: 541 LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM 600
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
Sbjct: 541 LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM 600
Query: 601 GENNTLVWKYADAGHVCHLCHPNCTYGS 628
GENNTLVWKYADAGHVCHLCHPNCTYGS
Sbjct: 601 GENNTLVWKYADAGHVCHLCHPNCTYGS 628
>gi|29725609 epidermal growth factor receptor isoform a precursor
[Homo sapiens]
Length = 1210
Score = 1334 bits (3452), Expect = 0.0
Identities = 627/627 (100%), Positives = 627/627 (100%)
Query: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
Sbjct: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
Query: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
Sbjct: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
Query: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
Sbjct: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
Query: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
Sbjct: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
Query: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
Sbjct: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
Query: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
Sbjct: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
Query: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF 420
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
Sbjct: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF 420
Query: 421 ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL 480
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
Sbjct: 421 ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL 480
Query: 481 FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN 540
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
Sbjct: 481 FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN 540
Query: 541 LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM 600
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
Sbjct: 541 LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM 600
Query: 601 GENNTLVWKYADAGHVCHLCHPNCTYG 627
GENNTLVWKYADAGHVCHLCHPNCTYG
Sbjct: 601 GENNTLVWKYADAGHVCHLCHPNCTYG 627
Score = 73.2 bits (178), Expect = 7e-13
Identities = 74/319 (23%), Positives = 109/319 (34%), Gaps = 108/319 (33%)
Query: 29 KVCQGTSNKLTQ---LGTFEDHFLSLQ----RMFNNCEVVLGNLEITYVQRNYD------ 75
K C+G K+ +G F+D LS+ + F NC + G+L I V D
Sbjct: 327 KKCEGPCRKVCNGIGIGEFKDS-LSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTP 385
Query: 76 ------LSFLKTIQEVAGYVLIAL---NTVERIPLENLQIIRGNMYYENSYALAVLSNYD 126
L LKT++E+ G++LI N + ENL+IIRG ++LAV+S
Sbjct: 386 PLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVS--- 442
Query: 127 ANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSD-----FLSNMSMDFQ 181
+ L +R+L+EI G V S N LC +I W+ + + +SN +
Sbjct: 443 ---LNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSC 499
Query: 182 NHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGR------------------- 222
G Q C C CWG +C + ++C +
Sbjct: 500 KATG--QVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQ 557
Query: 223 -------------CRGKSPSDC-------------------------------------- 231
C G+ P +C
Sbjct: 558 CHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVC 617
Query: 232 --CHNQCAAGCTGPRESDC 248
CH C GCTGP C
Sbjct: 618 HLCHPNCTYGCTGPGLEGC 636
>gi|41327736 epidermal growth factor receptor isoform d precursor
[Homo sapiens]
Length = 705
Score = 1334 bits (3452), Expect = 0.0
Identities = 627/627 (100%), Positives = 627/627 (100%)
Query: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
Sbjct: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
Query: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
Sbjct: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
Query: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
Sbjct: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
Query: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
Sbjct: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
Query: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
Sbjct: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
Query: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
Sbjct: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
Query: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF 420
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
Sbjct: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF 420
Query: 421 ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL 480
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
Sbjct: 421 ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL 480
Query: 481 FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN 540
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
Sbjct: 481 FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN 540
Query: 541 LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM 600
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
Sbjct: 541 LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM 600
Query: 601 GENNTLVWKYADAGHVCHLCHPNCTYG 627
GENNTLVWKYADAGHVCHLCHPNCTYG
Sbjct: 601 GENNTLVWKYADAGHVCHLCHPNCTYG 627
>gi|41327734 epidermal growth factor receptor isoform c precursor
[Homo sapiens]
Length = 405
Score = 847 bits (2188), Expect = 0.0
Identities = 403/403 (100%), Positives = 403/403 (100%)
Query: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
Sbjct: 1 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV 60
Query: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
Sbjct: 61 VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA 120
Query: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
Sbjct: 121 VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF 180
Query: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
Sbjct: 181 QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC 240
Query: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
Sbjct: 241 TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV 300
Query: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
Sbjct: 301 VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK 360
Query: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITG 403
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITG
Sbjct: 361 NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITG 403
Score = 94.4 bits (233), Expect = 3e-19
Identities = 78/277 (28%), Positives = 116/277 (41%), Gaps = 53/277 (19%)
Query: 334 RKVCNGIG-----IGEFKDS-LSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPL 387
+KVC G +G F+D LS+ + F NC + G+L I V D
Sbjct: 28 KKVCQGTSNKLTQLGTFEDHFLSLQ----RMFNNCEVVLGNLEITYVQRNYD-------- 75
Query: 388 DPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVS----- 442
L LKT++E+ G++LI N + ENL+IIRG ++LAV+S
Sbjct: 76 ----LSFLKTIQEVAGYVLIAL---NTVERIPLENLQIIRGNMYYENSYALAVLSNYDAN 128
Query: 443 -LNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKA 501
+ L +R+L+EI G V S N LC +I W+ + + +SN +
Sbjct: 129 KTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSD-----FLSNMSMDFQNH 183
Query: 502 TG--QVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCH 559
G Q C C CWG +C + ++C +C G+ S+C CH
Sbjct: 184 LGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRC---RGK-----SPSDC--CH 233
Query: 560 PECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCP 596
+C CTG +C+ C + D C TCP
Sbjct: 234 NQCA-----AGCTGPRESDCLVCRKFRDEATCKDTCP 265
>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog
4 isoform JM-a/CVT-2 precursor [Homo sapiens]
Length = 1292
Score = 631 bits (1627), Expect = 0.0
Identities = 293/605 (48%), Positives = 392/605 (64%), Gaps = 7/605 (1%)
Query: 26 EEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEV 85
+ + VC GT NKL+ L E + +L++ + NCEVV+GNLEIT ++ N DLSFL++++EV
Sbjct: 24 DSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREV 83
Query: 86 AGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNY--DANKTGLKELPMRNLQEI 143
GYVL+ALN +PLENL+IIRG YE+ YALA+ NY D N GL+EL ++NL EI
Sbjct: 84 TGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGN-FGLQELGLKNLTEI 142
Query: 144 LHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAG 203
L+G V N LC ++I W+DIV + + SN+++ N C +C SC G CWG
Sbjct: 143 LNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSC-TGRCWGPT 201
Query: 204 EENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDT 263
E +CQ LT+ +CA+QC GRC G SDCCH +CA GC+GP+++DC C F D C
Sbjct: 202 ENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQ 261
Query: 264 CPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGV 323
CP +YNPTT+Q++ N KY++GA CVKKCP N+VV D SCVRAC + E+EE+G+
Sbjct: 262 CPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVV-DSSSCVRACPSSKMEVEENGI 320
Query: 324 RKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTH 383
+ CK C C K C+GIG G + +++++NI F NCT I+G+L L GD +
Sbjct: 321 KMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNA 380
Query: 384 TPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSL 443
+DP++L++ +TV+EITGFL IQ+WP N TD F NL I GR G L +
Sbjct: 381 IEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQ 440
Query: 444 NITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATG 503
ITSL +SLKEIS G++ I+ N NLCY +TINW LF T Q+ I NR +C A G
Sbjct: 441 GITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEG 500
Query: 504 QVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECL 563
VC+ LCS +GCWGP P C+SCR SRGR C++ CNL +GE REF S C++C P+C
Sbjct: 501 MVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCE 560
Query: 564 PQAMN-ITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHP 622
+TC G GPDNC +C+H+ DGP+CV+ CP G+ G N+ ++KYAD CH CHP
Sbjct: 561 KMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA-NSFIFKYADPDRECHPCHP 619
Query: 623 NCTYG 627
NCT G
Sbjct: 620 NCTQG 624
Score = 68.6 bits (166), Expect = 2e-11
Identities = 74/320 (23%), Positives = 115/320 (35%), Gaps = 83/320 (25%)
Query: 55 FNNCEVVLGNLEITYVQRNYD------------LSFLKTIQEVAGYVLIAL---NTVERI 99
F NC + GNL + D L+ +T++E+ G++ I N +
Sbjct: 356 FINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFS 415
Query: 100 PLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNV 159
NL I G + Y LS + G+ L ++L+EI G + ++N LC
Sbjct: 416 VFSNLVTIGGRVLYSG------LSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYY 469
Query: 160 ESIQWRDIVSS---DFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKI--- 213
+I W + S+ + + +N C+ C + CWG G + C +
Sbjct: 470 HTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRG 529
Query: 214 -ICAQQCS---GRCRG-KSPSDC--CHNQCAA------GCTGPRESDCLVCRKFRDEATC 260
IC + C+ G R ++ S C C QC C GP +C C F+D
Sbjct: 530 RICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKD---- 585
Query: 261 KDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEME- 319
G CV+KCP GA+S+ +
Sbjct: 586 ---------------------------GPNCVEKCPDGLQ-----------GANSFIFKY 607
Query: 320 EDGVRKCKKCEGPCRKVCNG 339
D R+C C C + CNG
Sbjct: 608 ADPDRECHPCHPNCTQGCNG 627
>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-1 precursor [Homo sapiens]
Length = 1308
Score = 631 bits (1627), Expect = 0.0
Identities = 293/605 (48%), Positives = 392/605 (64%), Gaps = 7/605 (1%)
Query: 26 EEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEV 85
+ + VC GT NKL+ L E + +L++ + NCEVV+GNLEIT ++ N DLSFL++++EV
Sbjct: 24 DSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREV 83
Query: 86 AGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNY--DANKTGLKELPMRNLQEI 143
GYVL+ALN +PLENL+IIRG YE+ YALA+ NY D N GL+EL ++NL EI
Sbjct: 84 TGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGN-FGLQELGLKNLTEI 142
Query: 144 LHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAG 203
L+G V N LC ++I W+DIV + + SN+++ N C +C SC G CWG
Sbjct: 143 LNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSC-TGRCWGPT 201
Query: 204 EENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDT 263
E +CQ LT+ +CA+QC GRC G SDCCH +CA GC+GP+++DC C F D C
Sbjct: 202 ENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQ 261
Query: 264 CPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGV 323
CP +YNPTT+Q++ N KY++GA CVKKCP N+VV D SCVRAC + E+EE+G+
Sbjct: 262 CPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVV-DSSSCVRACPSSKMEVEENGI 320
Query: 324 RKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTH 383
+ CK C C K C+GIG G + +++++NI F NCT I+G+L L GD +
Sbjct: 321 KMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNA 380
Query: 384 TPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSL 443
+DP++L++ +TV+EITGFL IQ+WP N TD F NL I GR G L +
Sbjct: 381 IEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQ 440
Query: 444 NITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATG 503
ITSL +SLKEIS G++ I+ N NLCY +TINW LF T Q+ I NR +C A G
Sbjct: 441 GITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEG 500
Query: 504 QVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECL 563
VC+ LCS +GCWGP P C+SCR SRGR C++ CNL +GE REF S C++C P+C
Sbjct: 501 MVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCE 560
Query: 564 PQAMN-ITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHP 622
+TC G GPDNC +C+H+ DGP+CV+ CP G+ G N+ ++KYAD CH CHP
Sbjct: 561 KMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA-NSFIFKYADPDRECHPCHP 619
Query: 623 NCTYG 627
NCT G
Sbjct: 620 NCTQG 624
Score = 68.6 bits (166), Expect = 2e-11
Identities = 74/320 (23%), Positives = 115/320 (35%), Gaps = 83/320 (25%)
Query: 55 FNNCEVVLGNLEITYVQRNYD------------LSFLKTIQEVAGYVLIAL---NTVERI 99
F NC + GNL + D L+ +T++E+ G++ I N +
Sbjct: 356 FINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFS 415
Query: 100 PLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNV 159
NL I G + Y LS + G+ L ++L+EI G + ++N LC
Sbjct: 416 VFSNLVTIGGRVLYSG------LSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYY 469
Query: 160 ESIQWRDIVSS---DFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKI--- 213
+I W + S+ + + +N C+ C + CWG G + C +
Sbjct: 470 HTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRG 529
Query: 214 -ICAQQCS---GRCRG-KSPSDC--CHNQCAA------GCTGPRESDCLVCRKFRDEATC 260
IC + C+ G R ++ S C C QC C GP +C C F+D
Sbjct: 530 RICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKD---- 585
Query: 261 KDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEME- 319
G CV+KCP GA+S+ +
Sbjct: 586 ---------------------------GPNCVEKCPDGLQ-----------GANSFIFKY 607
Query: 320 EDGVRKCKKCEGPCRKVCNG 339
D R+C C C + CNG
Sbjct: 608 ADPDRECHPCHPNCTQGCNG 627
>gi|54792100 erbB-3 isoform 1 precursor [Homo sapiens]
Length = 1342
Score = 591 bits (1524), Expect = e-169
Identities = 280/620 (45%), Positives = 382/620 (61%), Gaps = 11/620 (1%)
Query: 11 LLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYV 70
+L LL +L S + VC GT N L+ G E+ + +L +++ CEVV+GNLEI
Sbjct: 9 VLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLT 68
Query: 71 QRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKT 130
N DLSFL+ I+EV GYVL+A+N +PL NL+++RG Y+ +A+ V+ NY+ N +
Sbjct: 69 GHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSS 128
Query: 131 -GLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQK 189
L++L + L EIL G V N LC++++I WRDIV + + +++ SC
Sbjct: 129 HALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRD---RDAEIVVKDNGRSCPP 185
Query: 190 CDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCL 249
C C G CWG G E+CQ LTK ICA QC+G C G +P+ CCH++CA GC+GP+++DC
Sbjct: 186 CHEVC-KGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCF 244
Query: 250 VCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVR 309
CR F D C CP ++YN T+Q++ NP KY +G CV CP N+VV D SCVR
Sbjct: 245 ACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVV-DQTSCVR 303
Query: 310 ACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDL 369
AC D E++++G++ C+ C G C K C G G G + ++++NI F NCT I G+L
Sbjct: 304 ACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQT--VDSSNIDGFVNCTKILGNL 361
Query: 370 HILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGR 429
L GD + P LDP++L++ +TV+EITG+L IQ+WP + + F NL I GR
Sbjct: 362 DFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGR 421
Query: 430 TKQHGQFSLAVV-SLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLF-GTSGQK 487
+ + FSL ++ +LN+TSLG RSLKEIS G + IS N+ LCY +++NW K+ G + ++
Sbjct: 422 SLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEER 481
Query: 488 TKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPR 547
I NR C A G+VC LCS GCWGP P C+SCRN SRG CV CN L GEPR
Sbjct: 482 LDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPR 541
Query: 548 EFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLV 607
EF +EC CHPEC P TC G G D C QCAH+ DGPHCV +CP GV+G +
Sbjct: 542 EFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGP-I 600
Query: 608 WKYADAGHVCHLCHPNCTYG 627
+KY D + C CH NCT G
Sbjct: 601 YKYPDVQNECRPCHENCTQG 620
Score = 50.4 bits (119), Expect = 5e-06
Identities = 70/318 (22%), Positives = 106/318 (33%), Gaps = 99/318 (31%)
Query: 18 LCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYD-- 75
LCP K C+GT + F+ S F NC +LGNL+ N D
Sbjct: 326 LCP--------KACEGTGSG----SRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPW 373
Query: 76 ----------LSFLKTIQEVAGYVLIAL---NTVERIPLENLQIIRGNMYYENSYALAVL 122
L+ +T++E+ GY+ I + NL I G Y ++L ++
Sbjct: 374 HKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIM 433
Query: 123 SNYDANKTG---LKELPM------RNLQEILHGAVRFS---------------NNPA--- 155
N + G LKE+ N Q H ++ ++ N P
Sbjct: 434 KNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDC 493
Query: 156 ---------LCNV---------ESIQWRD-------IVSSDFLSNMSMDFQNHLGSCQKC 190
LC+ + + R+ + +FL+ +F H C C
Sbjct: 494 VAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFA-HEAECFSC 552
Query: 191 DPSCP----NGSCWGAGEENCQKLTKIICAQQCSGRCR-----GKSP--------SDC-- 231
P C +C G+G + C + C C K P ++C
Sbjct: 553 HPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRP 612
Query: 232 CHNQCAAGCTGPRESDCL 249
CH C GC GP DCL
Sbjct: 613 CHENCTQGCKGPELQDCL 630
>gi|54792096 erbB-2 isoform a [Homo sapiens]
Length = 1255
Score = 580 bits (1495), Expect = e-165
Identities = 275/625 (44%), Positives = 381/625 (60%), Gaps = 15/625 (2%)
Query: 14 LLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRN 73
LL AL P A +VC GT KL + E H L+ ++ C+VV GNLE+TY+ N
Sbjct: 11 LLLALLPPGAA--STQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTN 68
Query: 74 YDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYD------- 126
LSFL+ IQEV GYVLIA N V ++PL+ L+I+RG +E++YALAVL N D
Sbjct: 69 ASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTP 128
Query: 127 ---ANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNH 183
A+ GL+EL +R+L EIL G V NP LC ++I W+DI + +++ N
Sbjct: 129 VTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNR 188
Query: 184 LGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGP 243
+C C P C CWG E+CQ LT+ +CA C+ RC+G P+DCCH QCAAGCTGP
Sbjct: 189 SRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCA-RCKGPLPTDCCHEQCAAGCTGP 247
Query: 244 RESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTD 303
+ SDCL C F C+ CP L+ YN T++ NPEG+Y+FGA+CV CP NY+ TD
Sbjct: 248 KHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTD 307
Query: 304 HGSCVRACGADSYEME-EDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNC 362
GSC C + E+ EDG ++C+KC PC +VC G+G+ ++ ++ + NI+ F C
Sbjct: 308 VGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGC 367
Query: 363 TSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFEN 422
I G L LP +F GD ++T PL P++L + +T++EITG+L I AWP++ DL F+N
Sbjct: 368 KKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQN 427
Query: 423 LEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFG 482
L++IRGR +G +SL + L I+ LGLRSL+E+ G +I N +LC+ +T+ W +LF
Sbjct: 428 LQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFR 487
Query: 483 TSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLL 542
Q +NR E+ C G CH LC+ CWGP P CV+C RG+ECV++C +L
Sbjct: 488 NPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVL 547
Query: 543 EGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGE 602
+G PRE+V C+ CHPEC PQ ++TC G D C+ CAHY D P CV CP+GV +
Sbjct: 548 QGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPD 607
Query: 603 NNTL-VWKYADAGHVCHLCHPNCTY 626
+ + +WK+ D C C NCT+
Sbjct: 608 LSYMPIWKFPDEEGACQPCPINCTH 632
>gi|54792098 erbB-2 isoform b [Homo sapiens]
Length = 1225
Score = 568 bits (1464), Expect = e-162
Identities = 263/594 (44%), Positives = 367/594 (61%), Gaps = 13/594 (2%)
Query: 45 EDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENL 104
E H L+ ++ C+VV GNLE+TY+ N LSFL+ IQEV GYVLIA N V ++PL+ L
Sbjct: 10 ETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRL 69
Query: 105 QIIRGNMYYENSYALAVLSNYD----------ANKTGLKELPMRNLQEILHGAVRFSNNP 154
+I+RG +E++YALAVL N D A+ GL+EL +R+L EIL G V NP
Sbjct: 70 RIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNP 129
Query: 155 ALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKII 214
LC ++I W+DI + +++ N +C C P C CWG E+CQ LT+ +
Sbjct: 130 QLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTV 189
Query: 215 CAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTT 274
CA C+ RC+G P+DCCH QCAAGCTGP+ SDCL C F C+ CP L+ YN T
Sbjct: 190 CAGGCA-RCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDT 248
Query: 275 YQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEME-EDGVRKCKKCEGPC 333
++ NPEG+Y+FGA+CV CP NY+ TD GSC C + E+ EDG ++C+KC PC
Sbjct: 249 FESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPC 308
Query: 334 RKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELD 393
+VC G+G+ ++ ++ + NI+ F C I G L LP +F GD ++T PL P++L
Sbjct: 309 ARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQ 368
Query: 394 ILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSL 453
+ +T++EITG+L I AWP++ DL F+NL++IRGR +G +SL + L I+ LGLRSL
Sbjct: 369 VFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSL 428
Query: 454 KEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPE 513
+E+ G +I N +LC+ +T+ W +LF Q +NR E+ C G CH LC+
Sbjct: 429 RELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARG 488
Query: 514 GCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTG 573
CWGP P CV+C RG+ECV++C +L+G PRE+V C+ CHPEC PQ ++TC G
Sbjct: 489 HCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFG 548
Query: 574 RGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTL-VWKYADAGHVCHLCHPNCTY 626
D C+ CAHY D P CV CP+GV + + + +WK+ D C C NCT+
Sbjct: 549 PEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTH 602
>gi|119395738 insulin receptor isoform Short precursor [Homo
sapiens]
Length = 1370
Score = 133 bits (334), Expect = 6e-31
Identities = 155/545 (28%), Positives = 232/545 (42%), Gaps = 94/545 (17%)
Query: 1 MRPSGTAGAA----LLALLAALCPASRALEEKKVCQGTS--NKLTQLGTFEDHFLSLQRM 54
M G GAA L+A+ A L A+ L +VC G N LT+L E
Sbjct: 1 MATGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELE--------- 51
Query: 55 FNNCEVVLGNLEITYVQRNY-----DLSFLKTIQEVAGYVLIALNTVERIP--LENLQII 107
NC V+ G+L+I + + DLSF K I +L + +E + NL +I
Sbjct: 52 --NCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVI 109
Query: 108 RGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDI 167
RG+ + N YAL + LKEL + NL I G+VR N LC + +I W I
Sbjct: 110 RGSRLFFN-YALVIFE-----MVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRI 163
Query: 168 VSS--DFLSNMSMDFQNHLG----SCQKCDPSCP----NGS----CWGAGEENCQKLTKI 213
+ S D ++ D G K +CP NG CW +CQK+
Sbjct: 164 LDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCW--THSHCQKVCPT 221
Query: 214 ICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRE-SDCLVCRKFRDEATCKDTCPPLMLYNP 272
IC S C + CCH++C C+ P + + C+ CR F + C +TCPP P
Sbjct: 222 ICK---SHGCTAEGL--CCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPP-----P 271
Query: 273 TTYQMD---VNPEGKYSFGATCVKKCPR------NYVVTDHGSCVRACGADSYEMEEDGV 323
+ D VN +SF KC + V + C+ C Y M +
Sbjct: 272 YYHFQDWRCVN----FSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPEC-PSGYTMNSSNL 326
Query: 324 RKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTH 383
C C GPC KVC+ + + DS+ T+ + + CT I+G L I RG +
Sbjct: 327 -LCTPCLGPCPKVCHLLEGEKTIDSV----TSAQELRGCTVINGSLII---NIRGGNNL- 377
Query: 384 TPPLDPQELDI-LKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSL-AVV 441
EL+ L ++EI+G+L I+ L F L +IRG T + G +S A+
Sbjct: 378 -----AAELEANLGLIEEISGYLKIRR-SYALVSLSFFRKLRLIRGETLEIGNYSFYALD 431
Query: 442 SLNITSLGLRSLKE--ISDGDVIISGNKNLCYANTINWKKLFGTSGQKTK----IISNRG 495
+ N+ L S I+ G + N LC + +++ GT G++ + + +N
Sbjct: 432 NQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGD 491
Query: 496 ENSCK 500
+ SC+
Sbjct: 492 QASCE 496
Score = 75.9 bits (185), Expect = 1e-13
Identities = 89/345 (25%), Positives = 134/345 (38%), Gaps = 78/345 (22%)
Query: 335 KVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDI 394
+VC G+ I N T + +NC+ I G L IL + F+ T P D ++L
Sbjct: 33 EVCPGMDIRN-------NLTRLHELENCSVIEGHLQIL-LMFK------TRPEDFRDLSF 78
Query: 395 LKTVKEITGFLLIQAWP-ENRTDLHAFENLEIIRGRTKQHGQFSLAVVSL-NITSLGLRS 452
K + LL + + E+ DL F NL +IRG ++ ++L + + ++ LGL +
Sbjct: 79 PKLIMITDYLLLFRVYGLESLKDL--FPNLTVIRG-SRLFFNYALVIFEMVHLKELGLYN 135
Query: 453 LKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISN---------------RGEN 497
L I+ G V I N LCY TI+W ++ S + I+ N +G+
Sbjct: 136 LMNITRGSVRIEKNNELCYLATIDWSRIL-DSVEDNYIVLNKDDNEECGDICPGTAKGKT 194
Query: 498 SCKAT---GQ-------------VCHALCSPEGCWG----------------PEPRDCVS 525
+C AT GQ VC +C GC +P CV+
Sbjct: 195 NCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVA 254
Query: 526 CRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHY 585
CRN CV+ C P ++ C+ Q ++ C C Q +
Sbjct: 255 CRNFYLDGRCVETC----PPPYYHFQDWRCVNF---SFCQDLHHKCKNSRRQGCHQ--YV 305
Query: 586 IDGPHCVKTCPAG-VMGENNTLVWK-YADAGHVCHLCHPNCTYGS 628
I C+ CP+G M +N L VCHL T S
Sbjct: 306 IHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDS 350
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 133 bits (334), Expect = 6e-31
Identities = 155/545 (28%), Positives = 232/545 (42%), Gaps = 94/545 (17%)
Query: 1 MRPSGTAGAA----LLALLAALCPASRALEEKKVCQGTS--NKLTQLGTFEDHFLSLQRM 54
M G GAA L+A+ A L A+ L +VC G N LT+L E
Sbjct: 1 MATGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELE--------- 51
Query: 55 FNNCEVVLGNLEITYVQRNY-----DLSFLKTIQEVAGYVLIALNTVERIP--LENLQII 107
NC V+ G+L+I + + DLSF K I +L + +E + NL +I
Sbjct: 52 --NCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVI 109
Query: 108 RGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDI 167
RG+ + N YAL + LKEL + NL I G+VR N LC + +I W I
Sbjct: 110 RGSRLFFN-YALVIFE-----MVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRI 163
Query: 168 VSS--DFLSNMSMDFQNHLG----SCQKCDPSCP----NGS----CWGAGEENCQKLTKI 213
+ S D ++ D G K +CP NG CW +CQK+
Sbjct: 164 LDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCW--THSHCQKVCPT 221
Query: 214 ICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRE-SDCLVCRKFRDEATCKDTCPPLMLYNP 272
IC S C + CCH++C C+ P + + C+ CR F + C +TCPP P
Sbjct: 222 ICK---SHGCTAEGL--CCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPP-----P 271
Query: 273 TTYQMD---VNPEGKYSFGATCVKKCPR------NYVVTDHGSCVRACGADSYEMEEDGV 323
+ D VN +SF KC + V + C+ C Y M +
Sbjct: 272 YYHFQDWRCVN----FSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPEC-PSGYTMNSSNL 326
Query: 324 RKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTH 383
C C GPC KVC+ + + DS+ T+ + + CT I+G L I RG +
Sbjct: 327 -LCTPCLGPCPKVCHLLEGEKTIDSV----TSAQELRGCTVINGSLII---NIRGGNNL- 377
Query: 384 TPPLDPQELDI-LKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSL-AVV 441
EL+ L ++EI+G+L I+ L F L +IRG T + G +S A+
Sbjct: 378 -----AAELEANLGLIEEISGYLKIRR-SYALVSLSFFRKLRLIRGETLEIGNYSFYALD 431
Query: 442 SLNITSLGLRSLKE--ISDGDVIISGNKNLCYANTINWKKLFGTSGQKTK----IISNRG 495
+ N+ L S I+ G + N LC + +++ GT G++ + + +N
Sbjct: 432 NQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGD 491
Query: 496 ENSCK 500
+ SC+
Sbjct: 492 QASCE 496
Score = 75.9 bits (185), Expect = 1e-13
Identities = 89/345 (25%), Positives = 134/345 (38%), Gaps = 78/345 (22%)
Query: 335 KVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDI 394
+VC G+ I N T + +NC+ I G L IL + F+ T P D ++L
Sbjct: 33 EVCPGMDIRN-------NLTRLHELENCSVIEGHLQIL-LMFK------TRPEDFRDLSF 78
Query: 395 LKTVKEITGFLLIQAWP-ENRTDLHAFENLEIIRGRTKQHGQFSLAVVSL-NITSLGLRS 452
K + LL + + E+ DL F NL +IRG ++ ++L + + ++ LGL +
Sbjct: 79 PKLIMITDYLLLFRVYGLESLKDL--FPNLTVIRG-SRLFFNYALVIFEMVHLKELGLYN 135
Query: 453 LKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISN---------------RGEN 497
L I+ G V I N LCY TI+W ++ S + I+ N +G+
Sbjct: 136 LMNITRGSVRIEKNNELCYLATIDWSRIL-DSVEDNYIVLNKDDNEECGDICPGTAKGKT 194
Query: 498 SCKAT---GQ-------------VCHALCSPEGCWG----------------PEPRDCVS 525
+C AT GQ VC +C GC +P CV+
Sbjct: 195 NCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVA 254
Query: 526 CRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHY 585
CRN CV+ C P ++ C+ Q ++ C C Q +
Sbjct: 255 CRNFYLDGRCVETC----PPPYYHFQDWRCVNF---SFCQDLHHKCKNSRRQGCHQ--YV 305
Query: 586 IDGPHCVKTCPAG-VMGENNTLVWK-YADAGHVCHLCHPNCTYGS 628
I C+ CP+G M +N L VCHL T S
Sbjct: 306 IHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDS 350
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 109 bits (272), Expect = 9e-24
Identities = 126/484 (26%), Positives = 197/484 (40%), Gaps = 75/484 (15%)
Query: 53 RMFNNCEVVLGNLEITYV-----QRNYDLSFLKTIQEVAGYVLIALNTVERIP--LENLQ 105
R NC VV G+L+I + + LSF + Q +L + +E + NL
Sbjct: 43 RQLENCSVVEGHLQILLMFTATGEDFRGLSFPRLTQVTDYLLLFRVYGLESLRDLFPNLA 102
Query: 106 IIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWR 165
+IRG + YAL + L+++ + L +L GAVR N LC++ +I W
Sbjct: 103 VIRGTRLFLG-YALVIFE-----MPHLRDVALPALGAVLRGAVRVEKNQELCHLSTIDWG 156
Query: 166 DIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLT-------KIICAQQ 218
+ + +++ N LG ++C CP GA E C K T + +
Sbjct: 157 LLQPAPGANHI---VGNKLG--EECADVCP--GVLGAAGEPCAKTTFSGHTDYRCWTSSH 209
Query: 219 CSGRC------RGKSPSDCCHNQCAAGCTGPRE-SDCLVCRKFRDEATCKDTCPPLMLYN 271
C C + +CCH +C GC+ P + C+ CR + C CP
Sbjct: 210 CQRVCPCPHGMACTARGECCHTECLGGCSQPEDPRACVACRHLYFQGACLWACP------ 263
Query: 272 PTTYQMDVNPEGKYSFGATCVKKCPRNYVV--------TDHGSCVRACGADSYEMEEDGV 323
P TYQ + S+ ++C + V GSC+ C + +
Sbjct: 264 PGTYQYE-------SWRCVTAERCASLHSVPGRASTFGIHQGSCLAQC-PSGFTRNSSSI 315
Query: 324 RKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTH 383
C KCEG C K C +G K SI A + CT + G L + +
Sbjct: 316 -FCHKCEGLCPKECK-VGT---KTIDSIQAA--QDLVGCTHVEGSLIL--------NLRQ 360
Query: 384 TPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVV-S 442
L+PQ L V+ ITGFL I+ L F+NL++IRG G ++L V+ +
Sbjct: 361 GYNLEPQLQHSLGLVETITGFLKIK-HSFALVSLGFFKNLKLIRGDAMVDGNYTLYVLDN 419
Query: 443 LNITSLG--LRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCK 500
N+ LG + + I G + + N LC + +++ GT G++ K N N +
Sbjct: 420 QNLQQLGSWVAAGLTIPVGKIYFAFNPRLCLEHIYRLEEVTGTRGRQNKAEINPRTNGDR 479
Query: 501 ATGQ 504
A Q
Sbjct: 480 AACQ 483
Score = 51.2 bits (121), Expect = 3e-06
Identities = 74/343 (21%), Positives = 120/343 (34%), Gaps = 98/343 (28%)
Query: 339 GIGIGEFKDSLSINA--TNIKHFKNCTSISGDLHILPVA------FRGDSFTHTPPLDPQ 390
G+ E SL I + ++ +NC+ + G L IL + FRG SF
Sbjct: 23 GLDTVEVCPSLDIRSEVAELRQLENCSVVEGHLQILLMFTATGEDFRGLSFPR------- 75
Query: 391 ELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSL-NITSLG 449
+ ++T +LL+ + F NL +IRG T+ ++L + + ++ +
Sbjct: 76 -------LTQVTDYLLLFRVYGLESLRDLFPNLAVIRG-TRLFLGYALVIFEMPHLRDVA 127
Query: 450 LRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGEN------------ 497
L +L + G V + N+ LC+ +TI+W L G + + GE
Sbjct: 128 LPALGAVLRGAVRVEKNQELCHLSTIDWGLLQPAPGANHIVGNKLGEECADVCPGVLGAA 187
Query: 498 ---------------------------------SCKATGQVCHALCSPEGCWGPE-PRDC 523
+C A G+ CH C GC PE PR C
Sbjct: 188 GEPCAKTTFSGHTDYRCWTSSHCQRVCPCPHGMACTARGECCHTECLG-GCSQPEDPRAC 246
Query: 524 VSCRNVSRGRECVDKC--NLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQ 581
V+CR++ C+ C + E V C H + GR
Sbjct: 247 VACRHLYFQGACLWACPPGTYQYESWRCVTAERCASLH----------SVPGRA------ 290
Query: 582 CAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNC 624
I C+ CP+G ++++ CH C C
Sbjct: 291 STFGIHQGSCLAQCPSGFTRNSSSI---------FCHKCEGLC 324
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 108 bits (270), Expect = 1e-23
Identities = 120/487 (24%), Positives = 199/487 (40%), Gaps = 83/487 (17%)
Query: 53 RMFNNCEVVLGNLEITYVQ-----RNYDLSFLKTIQEVAGYVLIALNTVERIP--LENLQ 105
+ NC V+ G L I + R+Y L I E +L + +E + NL
Sbjct: 47 KRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYL--LLFRVAGLESLGDLFPNLT 104
Query: 106 IIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWR 165
+IRG + N YAL + T LK++ + NL+ I GA+R N LC + ++ W
Sbjct: 105 VIRGWKLFYN-YALVIFE-----MTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWS 158
Query: 166 ---DIVSSDFLSNMSMDFQNHLGSCQKCDPSCP------------------NGSCWGAGE 204
D VS++++ ++C CP N CW
Sbjct: 159 LILDAVSNNYIVGNKPP--------KECGDLCPGTMEEKPMCEKTTINNEYNYRCWTT-- 208
Query: 205 ENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGP-RESDCLVCRKFRDEATCKDT 263
CQK+ C C R ++ ++CCH +C C+ P ++ C+ CR + C
Sbjct: 209 NRCQKM----CPSTCGKRACTEN-NECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPA 263
Query: 264 CPPLMLYNPTTYQMDVNPEGKYSFGATCV---KKCPRNYVVTDHGSCVRACGADSYEMEE 320
CP P TY+ + F A + +V+ D G C++ C +
Sbjct: 264 CP------PNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHD-GECMQECPSGFIRNGS 316
Query: 321 DGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDS 380
+ C CEGPC KVC E K + T+ + + CT G+L L RG++
Sbjct: 317 QSM-YCIPCEGPCPKVCE----EEKKTKTIDSVTSAQMLQGCTIFKGNL--LINIRRGNN 369
Query: 381 FTHTPPLDPQELD-ILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLA 439
EL+ + ++ +TG++ I+ L +NL +I G + G +S
Sbjct: 370 IA-------SELENFMGLIEVVTGYVKIR-HSHALVSLSFLKNLRLILGEEQLEGNYSFY 421
Query: 440 VV-SLNITSL---GLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRG 495
V+ + N+ L R+L I G + + N LC + +++ GT G+++K N
Sbjct: 422 VLDNQNLQQLWDWDHRNL-TIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTR 480
Query: 496 ENSCKAT 502
N +A+
Sbjct: 481 NNGERAS 487
Score = 80.9 bits (198), Expect = 3e-15
Identities = 75/248 (30%), Positives = 113/248 (45%), Gaps = 35/248 (14%)
Query: 356 IKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLI--QAWPEN 413
+K +NCT I G LHIL ++ D ++ P + IT +LL+ A E+
Sbjct: 46 LKRLENCTVIEGYLHILLISKAEDYRSYRFP----------KLTVITEYLLLFRVAGLES 95
Query: 414 RTDLHAFENLEIIRGRTKQHGQFSLAVVSL-NITSLGLRSLKEISDGDVIISGNKNLCYA 472
DL F NL +IRG K ++L + + N+ +GL +L+ I+ G + I N +LCY
Sbjct: 96 LGDL--FPNLTVIRG-WKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYL 152
Query: 473 NTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEG-CWGPEPRDCVSCRNVSR 531
+T++W + I+ N+ C G +C + C + + R +
Sbjct: 153 STVDWSLILDAVSNNY-IVGNKPPKEC---GDLCPGTMEEKPMCEKTTINNEYNYRCWTT 208
Query: 532 GRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDN---CIQCAHYIDG 588
R C C G+ R EN+EC CHPECL +C+ PDN C+ C HY
Sbjct: 209 NR-CQKMCPSTCGK-RACTENNEC--CHPECLG-----SCSA--PDNDTACVACRHYYYA 257
Query: 589 PHCVKTCP 596
CV CP
Sbjct: 258 GVCVPACP 265
Score = 30.0 bits (66), Expect = 6.7
Identities = 31/120 (25%), Positives = 47/120 (39%), Gaps = 25/120 (20%)
Query: 51 LQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGN 110
L+ EVV G ++I + LSFLK + ++I G
Sbjct: 374 LENFMGLIEVVTGYVKIRHSHALVSLSFLKNL----------------------RLILGE 411
Query: 111 MYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSS 170
E +Y+ VL N N L + RNL I G + F+ NP LC E + ++ +
Sbjct: 412 EQLEGNYSFYVLDN--QNLQQLWDWDHRNL-TIKAGKMYFAFNPKLCVSEIYRMEEVTGT 468
>gi|54792102 erbB-3 isoform s precursor [Homo sapiens]
Length = 183
Score = 106 bits (265), Expect = 6e-23
Identities = 53/131 (40%), Positives = 81/131 (61%), Gaps = 1/131 (0%)
Query: 11 LLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYV 70
+L LL +L S + VC GT N L+ G E+ + +L +++ CEVV+GNLEI
Sbjct: 9 VLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLT 68
Query: 71 QRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKT 130
N DLSFL+ I+EV GYVL+A+N +PL NL+++RG Y+ +A+ V+ NY+ N +
Sbjct: 69 GHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSS 128
Query: 131 -GLKELPMRNL 140
L++L + L
Sbjct: 129 HALRQLRLTQL 139
>gi|20336184 paired basic amino acid cleaving system 4 isoform h
preproprotein [Homo sapiens]
Length = 962
Score = 60.8 bits (146), Expect = 4e-09
Identities = 42/131 (32%), Positives = 54/131 (41%), Gaps = 31/131 (23%)
Query: 505 VCHALCSPEGCWGPEPRDCVSCRNVSRG-----RECVDKCNL-LEGEPREFVENSECIQC 558
VCH C +GC GP C++C + S G R+CV C L G+ C +C
Sbjct: 681 VCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGD----TAARRCRRC 736
Query: 559 HPECLPQAMNITCTGRGPDNCIQCA----HYIDGPHCVKTCPAGVMGENNTLVWKYADAG 614
H C TC+ R C+ C H+ + CV CPAG YAD
Sbjct: 737 HKGC------ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGF----------YADES 780
Query: 615 HV-CHLCHPNC 624
C CHP+C
Sbjct: 781 QKNCLKCHPSC 791
Score = 40.0 bits (92), Expect = 0.006
Identities = 32/105 (30%), Positives = 43/105 (40%), Gaps = 24/105 (22%)
Query: 506 CHALCSPEGCWGPEPRDCVSCR---NVSRGRECVDKCNLLEGEPREFVENS--ECIQCHP 560
CH C EP C C+ +++RG C+ C EP + ++ C +CH
Sbjct: 787 CHPSCKK---CVDEPEKCTVCKEGFSLARG-SCIPDC-----EPGTYFDSELIRCGECHH 837
Query: 561 ECLPQAMNITCTGRGPDNCIQCA---HYIDGPHCVKTCPAGVMGE 602
C TC G G + CI CA H+ D CV C G E
Sbjct: 838 TCG------TCVGPGREECIHCAKNFHFHDW-KCVPACGEGFYPE 875
Score = 39.7 bits (91), Expect = 0.008
Identities = 33/115 (28%), Positives = 43/115 (37%), Gaps = 14/115 (12%)
Query: 232 CHNQCA-AGCTGPRESDCLVCRKF-----RDEATCKDTCPPLMLYNPTT----YQMDVNP 281
CH +C GC GP CL C F + C C PL + T +
Sbjct: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC-PLGYFGDTAARRCRRCHKGC 740
Query: 282 EGKYSFGATCVKKCPRN-YVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRK 335
E S AT C R Y + +CV C A Y ++ + C KC C+K
Sbjct: 741 ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFY--ADESQKNCLKCHPSCKK 793
Score = 36.2 bits (82), Expect = 0.094
Identities = 41/178 (23%), Positives = 60/178 (33%), Gaps = 39/178 (21%)
Query: 190 CDPSCPNGSCWGAGEENCQ-----KLTKIICAQQCSGRCRGKSPSDC-------CHNQCA 237
C P C + C G + C L + +++C C D CH C
Sbjct: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 741
Query: 238 AGCTGPRESDCLVCRK----FRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVK 293
C+ + CL CR+ ++ TC C P + D + + +C K
Sbjct: 742 T-CSSRAATQCLSCRRGFYHHQEMNTCVTLC-------PAGFYADESQKNCLKCHPSC-K 792
Query: 294 KC---PRNYVVTD------HGSCVRACGADSYEMEE-----DGVRKCKKCEGPCRKVC 337
KC P V GSC+ C +Y E + C C GP R+ C
Sbjct: 793 KCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREEC 850
Score = 30.4 bits (67), Expect = 5.1
Identities = 24/83 (28%), Positives = 32/83 (38%), Gaps = 25/83 (30%)
Query: 186 SCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDC-------------- 231
+C KC PSC C + +K T +C + S RG DC
Sbjct: 783 NCLKCHPSCKK--C----VDEPEKCT--VCKEGFS-LARGSCIPDCEPGTYFDSELIRCG 833
Query: 232 -CHNQCAAGCTGPRESDCLVCRK 253
CH+ C C GP +C+ C K
Sbjct: 834 ECHHTCGT-CVGPGREECIHCAK 855
>gi|20336182 paired basic amino acid cleaving system 4 isoform g
preproprotein [Homo sapiens]
Length = 975
Score = 60.8 bits (146), Expect = 4e-09
Identities = 42/131 (32%), Positives = 54/131 (41%), Gaps = 31/131 (23%)
Query: 505 VCHALCSPEGCWGPEPRDCVSCRNVSRG-----RECVDKCNL-LEGEPREFVENSECIQC 558
VCH C +GC GP C++C + S G R+CV C L G+ C +C
Sbjct: 694 VCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGD----TAARRCRRC 749
Query: 559 HPECLPQAMNITCTGRGPDNCIQCA----HYIDGPHCVKTCPAGVMGENNTLVWKYADAG 614
H C TC+ R C+ C H+ + CV CPAG YAD
Sbjct: 750 HKGC------ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGF----------YADES 793
Query: 615 HV-CHLCHPNC 624
C CHP+C
Sbjct: 794 QKNCLKCHPSC 804
Score = 40.0 bits (92), Expect = 0.006
Identities = 32/105 (30%), Positives = 43/105 (40%), Gaps = 24/105 (22%)
Query: 506 CHALCSPEGCWGPEPRDCVSCR---NVSRGRECVDKCNLLEGEPREFVENS--ECIQCHP 560
CH C EP C C+ +++RG C+ C EP + ++ C +CH
Sbjct: 800 CHPSCKK---CVDEPEKCTVCKEGFSLARG-SCIPDC-----EPGTYFDSELIRCGECHH 850
Query: 561 ECLPQAMNITCTGRGPDNCIQCA---HYIDGPHCVKTCPAGVMGE 602
C TC G G + CI CA H+ D CV C G E
Sbjct: 851 TCG------TCVGPGREECIHCAKNFHFHDW-KCVPACGEGFYPE 888
Score = 39.7 bits (91), Expect = 0.008
Identities = 33/115 (28%), Positives = 43/115 (37%), Gaps = 14/115 (12%)
Query: 232 CHNQCA-AGCTGPRESDCLVCRKF-----RDEATCKDTCPPLMLYNPTT----YQMDVNP 281
CH +C GC GP CL C F + C C PL + T +
Sbjct: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC-PLGYFGDTAARRCRRCHKGC 753
Query: 282 EGKYSFGATCVKKCPRN-YVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRK 335
E S AT C R Y + +CV C A Y ++ + C KC C+K
Sbjct: 754 ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFY--ADESQKNCLKCHPSCKK 806
Score = 36.2 bits (82), Expect = 0.094
Identities = 41/178 (23%), Positives = 60/178 (33%), Gaps = 39/178 (21%)
Query: 190 CDPSCPNGSCWGAGEENCQ-----KLTKIICAQQCSGRCRGKSPSDC-------CHNQCA 237
C P C + C G + C L + +++C C D CH C
Sbjct: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 754
Query: 238 AGCTGPRESDCLVCRK----FRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVK 293
C+ + CL CR+ ++ TC C P + D + + +C K
Sbjct: 755 T-CSSRAATQCLSCRRGFYHHQEMNTCVTLC-------PAGFYADESQKNCLKCHPSC-K 805
Query: 294 KC---PRNYVVTD------HGSCVRACGADSYEMEE-----DGVRKCKKCEGPCRKVC 337
KC P V GSC+ C +Y E + C C GP R+ C
Sbjct: 806 KCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREEC 863
Score = 30.4 bits (67), Expect = 5.1
Identities = 24/83 (28%), Positives = 32/83 (38%), Gaps = 25/83 (30%)
Query: 186 SCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDC-------------- 231
+C KC PSC C + +K T +C + S RG DC
Sbjct: 796 NCLKCHPSCKK--C----VDEPEKCT--VCKEGFS-LARGSCIPDCEPGTYFDSELIRCG 846
Query: 232 -CHNQCAAGCTGPRESDCLVCRK 253
CH+ C C GP +C+ C K
Sbjct: 847 ECHHTCGT-CVGPGREECIHCAK 868
>gi|4505577 paired basic amino acid cleaving system 4 isoform a
preproprotein [Homo sapiens]
Length = 969
Score = 60.8 bits (146), Expect = 4e-09
Identities = 42/131 (32%), Positives = 54/131 (41%), Gaps = 31/131 (23%)
Query: 505 VCHALCSPEGCWGPEPRDCVSCRNVSRG-----RECVDKCNL-LEGEPREFVENSECIQC 558
VCH C +GC GP C++C + S G R+CV C L G+ C +C
Sbjct: 694 VCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGD----TAARRCRRC 749
Query: 559 HPECLPQAMNITCTGRGPDNCIQCA----HYIDGPHCVKTCPAGVMGENNTLVWKYADAG 614
H C TC+ R C+ C H+ + CV CPAG YAD
Sbjct: 750 HKGC------ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGF----------YADES 793
Query: 615 HV-CHLCHPNC 624
C CHP+C
Sbjct: 794 QKNCLKCHPSC 804
Score = 42.7 bits (99), Expect = 0.001
Identities = 37/127 (29%), Positives = 49/127 (38%), Gaps = 29/127 (22%)
Query: 506 CHALCSPEGCWGPEPRDCVSCR---NVSRGRECVDKCNLLEGEPREFVENS--ECIQCHP 560
CH C EP C C+ +++RG C+ C EP + ++ C +CH
Sbjct: 800 CHPSCKK---CVDEPEKCTVCKEGFSLARG-SCIPDC-----EPGTYFDSELIRCGECHH 850
Query: 561 ECLPQAMNITCTGRGPDNCIQCA---HYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVC 617
C TC G G + CI CA H+ D CV C G E + VC
Sbjct: 851 TCG------TCVGPGREECIHCAKNFHFHDW-KCVPACGEGFYPEEMPGL-----PHKVC 898
Query: 618 HLCHPNC 624
C NC
Sbjct: 899 RRCDENC 905
Score = 39.7 bits (91), Expect = 0.008
Identities = 33/115 (28%), Positives = 43/115 (37%), Gaps = 14/115 (12%)
Query: 232 CHNQCA-AGCTGPRESDCLVCRKF-----RDEATCKDTCPPLMLYNPTT----YQMDVNP 281
CH +C GC GP CL C F + C C PL + T +
Sbjct: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC-PLGYFGDTAARRCRRCHKGC 753
Query: 282 EGKYSFGATCVKKCPRN-YVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRK 335
E S AT C R Y + +CV C A Y ++ + C KC C+K
Sbjct: 754 ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFY--ADESQKNCLKCHPSCKK 806
Score = 36.2 bits (82), Expect = 0.094
Identities = 41/178 (23%), Positives = 60/178 (33%), Gaps = 39/178 (21%)
Query: 190 CDPSCPNGSCWGAGEENCQ-----KLTKIICAQQCSGRCRGKSPSDC-------CHNQCA 237
C P C + C G + C L + +++C C D CH C
Sbjct: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 754
Query: 238 AGCTGPRESDCLVCRK----FRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVK 293
C+ + CL CR+ ++ TC C P + D + + +C K
Sbjct: 755 T-CSSRAATQCLSCRRGFYHHQEMNTCVTLC-------PAGFYADESQKNCLKCHPSC-K 805
Query: 294 KC---PRNYVVTD------HGSCVRACGADSYEMEE-----DGVRKCKKCEGPCRKVC 337
KC P V GSC+ C +Y E + C C GP R+ C
Sbjct: 806 KCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREEC 863
Score = 30.4 bits (67), Expect = 5.1
Identities = 24/83 (28%), Positives = 32/83 (38%), Gaps = 25/83 (30%)
Query: 186 SCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDC-------------- 231
+C KC PSC C + +K T +C + S RG DC
Sbjct: 796 NCLKCHPSCKK--C----VDEPEKCT--VCKEGFS-LARGSCIPDCEPGTYFDSELIRCG 846
Query: 232 -CHNQCAAGCTGPRESDCLVCRK 253
CH+ C C GP +C+ C K
Sbjct: 847 ECHHTCGT-CVGPGREECIHCAK 868
>gi|20336180 paired basic amino acid cleaving system 4 isoform b
preproprotein [Homo sapiens]
Length = 956
Score = 60.8 bits (146), Expect = 4e-09
Identities = 42/131 (32%), Positives = 54/131 (41%), Gaps = 31/131 (23%)
Query: 505 VCHALCSPEGCWGPEPRDCVSCRNVSRG-----RECVDKCNL-LEGEPREFVENSECIQC 558
VCH C +GC GP C++C + S G R+CV C L G+ C +C
Sbjct: 681 VCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGD----TAARRCRRC 736
Query: 559 HPECLPQAMNITCTGRGPDNCIQCA----HYIDGPHCVKTCPAGVMGENNTLVWKYADAG 614
H C TC+ R C+ C H+ + CV CPAG YAD
Sbjct: 737 HKGC------ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGF----------YADES 780
Query: 615 HV-CHLCHPNC 624
C CHP+C
Sbjct: 781 QKNCLKCHPSC 791
Score = 42.7 bits (99), Expect = 0.001
Identities = 37/127 (29%), Positives = 49/127 (38%), Gaps = 29/127 (22%)
Query: 506 CHALCSPEGCWGPEPRDCVSCR---NVSRGRECVDKCNLLEGEPREFVENS--ECIQCHP 560
CH C EP C C+ +++RG C+ C EP + ++ C +CH
Sbjct: 787 CHPSCKK---CVDEPEKCTVCKEGFSLARG-SCIPDC-----EPGTYFDSELIRCGECHH 837
Query: 561 ECLPQAMNITCTGRGPDNCIQCA---HYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVC 617
C TC G G + CI CA H+ D CV C G E + VC
Sbjct: 838 TCG------TCVGPGREECIHCAKNFHFHDW-KCVPACGEGFYPEEMPGL-----PHKVC 885
Query: 618 HLCHPNC 624
C NC
Sbjct: 886 RRCDENC 892
Score = 39.7 bits (91), Expect = 0.008
Identities = 33/115 (28%), Positives = 43/115 (37%), Gaps = 14/115 (12%)
Query: 232 CHNQCA-AGCTGPRESDCLVCRKF-----RDEATCKDTCPPLMLYNPTT----YQMDVNP 281
CH +C GC GP CL C F + C C PL + T +
Sbjct: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVC-PLGYFGDTAARRCRRCHKGC 740
Query: 282 EGKYSFGATCVKKCPRN-YVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRK 335
E S AT C R Y + +CV C A Y ++ + C KC C+K
Sbjct: 741 ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFY--ADESQKNCLKCHPSCKK 793
Score = 36.2 bits (82), Expect = 0.094
Identities = 41/178 (23%), Positives = 60/178 (33%), Gaps = 39/178 (21%)
Query: 190 CDPSCPNGSCWGAGEENCQ-----KLTKIICAQQCSGRCRGKSPSDC-------CHNQCA 237
C P C + C G + C L + +++C C D CH C
Sbjct: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 741
Query: 238 AGCTGPRESDCLVCRK----FRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVK 293
C+ + CL CR+ ++ TC C P + D + + +C K
Sbjct: 742 T-CSSRAATQCLSCRRGFYHHQEMNTCVTLC-------PAGFYADESQKNCLKCHPSC-K 792
Query: 294 KC---PRNYVVTD------HGSCVRACGADSYEMEE-----DGVRKCKKCEGPCRKVC 337
KC P V GSC+ C +Y E + C C GP R+ C
Sbjct: 793 KCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREEC 850
Score = 30.4 bits (67), Expect = 5.1
Identities = 24/83 (28%), Positives = 32/83 (38%), Gaps = 25/83 (30%)
Query: 186 SCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDC-------------- 231
+C KC PSC C + +K T +C + S RG DC
Sbjct: 783 NCLKCHPSCKK--C----VDEPEKCT--VCKEGFS-LARGSCIPDCEPGTYFDSELIRCG 833
Query: 232 -CHNQCAAGCTGPRESDCLVCRK 253
CH+ C C GP +C+ C K
Sbjct: 834 ECHHTCGT-CVGPGREECIHCAK 855
>gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo
sapiens]
Length = 853
Score = 58.9 bits (141), Expect = 1e-08
Identities = 111/471 (23%), Positives = 166/471 (35%), Gaps = 81/471 (17%)
Query: 184 LGSCQKCDPSCPNGSCWGAGEENCQ------KLTKIICAQQCSGRCRGKSPSDC------ 231
+G C+ C +C +C G G + C +L + +C + GK +D
Sbjct: 118 MGECESCHRACE--TCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQP 175
Query: 232 CHNQCAAGCTGPRESDCLVCRK--FRDEATCKDTCPPLMLYNPTTYQMDVNPEG-KYSFG 288
CH+ C C G C C K + C +CP + + + E G
Sbjct: 176 CHSSCKT-CNGSATL-CTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAICSG 233
Query: 289 ATCVKKC---PRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEF 345
A KKC P + + G C C SY EDG+ C++C PCR C G
Sbjct: 234 ADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYA--EDGI--CERCSSPCR-TCE----GNA 284
Query: 346 KDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFL 405
+ S ++ H C + H VA +G H P + Q+ KT KE T
Sbjct: 285 TNCHSCEGGHVLHHGVCQENCPERH---VAVKG-VCKHCPEM-CQDCIHEKTCKECTPEF 339
Query: 406 LI------QAWPEN--RTDLHAFE-NLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEI 456
+ Q+ P H + + + + L + S + GL L+E
Sbjct: 340 FLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSWVLYDGL-CLEEC 398
Query: 457 SDGDVIISGNKNL--CYANTINWKKL-FGTSGQKTKIISNRGENSCKATGQV-------- 505
G K C+ + + T+ QK I++ RG SC A +
Sbjct: 399 PAGTYYEKETKECRDCHKSCLTCSSSGTCTTCQKGLIMNPRG--SCMANEKCSPSEYWDE 456
Query: 506 -------CHALCSPEGCWGPEPRDCVSC--RNVSRGRECVDKCNLLEGEPREFVENSECI 556
CH C C GP C +C ++ CV C EG + +++ C
Sbjct: 457 DAPGCKPCHVKCF--HCMGPAEDQCQTCPMNSLLLNTTCVKDCP--EGYYAD-EDSNRCA 511
Query: 557 QCHPECLPQAMNITCTGRGPDNCIQC--AHYIDGPHCVKTCPAGVMGENNT 605
CH C TC GR C C + G C+ C G +N+T
Sbjct: 512 HCHSSCR------TCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNST 556
Score = 55.1 bits (131), Expect = 2e-07
Identities = 46/166 (27%), Positives = 68/166 (40%), Gaps = 36/166 (21%)
Query: 470 CYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNV 529
C++ W +L G++ + G + +TG+ S +GC GP P DC+SC
Sbjct: 528 CHSCRPGWFQL----GKECLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRF 583
Query: 530 -----SRGRECVDKCNLLEGEPREFVENS--ECIQCHPECLPQAMNITCTGRGPDNCIQC 582
S+G EC C +VE S C +CHP C C G+G NC+ C
Sbjct: 584 FFLLRSKG-ECHRSC-----PDHYYVEQSTQTCERCHPTC------DQCKGKGALNCLSC 631
Query: 583 --AHYIDGPHCVKTCPAGV--MGENNTLVWKYADAGHVCHLCHPNC 624
++++ G C C G +GE C CH +C
Sbjct: 632 VWSYHLMGGICTSDCLVGEYRVGEGEKF---------NCEKCHESC 668
Score = 51.2 bits (121), Expect = 3e-06
Identities = 48/174 (27%), Positives = 66/174 (37%), Gaps = 27/174 (15%)
Query: 187 CQKCDPSCPNGSCWGAGEENCQKLTK--IICAQQCSGRCR-----GKSPSDC--CHNQCA 237
C C SC +C G C ++C +CR S C C+ C
Sbjct: 510 CAHCHSSCR--TCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCK 567
Query: 238 AGCTGPRESDCLVCRKF----RDEATCKDTCPPLMLYNPTTYQMD-VNP-----EGKYSF 287
GC GPR +DCL C +F R + C +CP +T + +P +GK
Sbjct: 568 -GCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGK--- 623
Query: 288 GATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIG 341
GA C +Y + G C C Y + E C+KC C + C G G
Sbjct: 624 GALNCLSCVWSYHLMG-GICTSDCLVGEYRVGEGEKFNCEKCHESCME-CKGPG 675
Score = 47.8 bits (112), Expect = 3e-05
Identities = 36/127 (28%), Positives = 50/127 (39%), Gaps = 30/127 (23%)
Query: 506 CHALCSPEGCWGPEPRDCVSCRN--VSRGRECVDKCNLLEGEPREFVENS--ECIQCHPE 561
CH+ C C G R C SCR G+EC+ +C EG + +NS C +C+
Sbjct: 513 CHSSCRT--CEGRHSRQCHSCRPGWFQLGKECLLQCR--EG---YYADNSTGRCERCNRS 565
Query: 562 CLPQAMNITCTGRGPDNCIQCAHYI----DGPHCVKTCPAGVMGENNTLVWKYADAGHVC 617
C C G P +C+ C + C ++CP E +T C
Sbjct: 566 CK------GCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQST---------QTC 610
Query: 618 HLCHPNC 624
CHP C
Sbjct: 611 ERCHPTC 617
Score = 44.7 bits (104), Expect = 3e-04
Identities = 42/152 (27%), Positives = 58/152 (38%), Gaps = 45/152 (29%)
Query: 497 NSCKATGQVCHALCSPEGCWGPE------------PRDCVSCRNVSRGRECV-------D 537
+SC+ + H +C E C PE P C C + +EC D
Sbjct: 288 HSCEGGHVLHHGVCQ-ENC--PERHVAVKGVCKHCPEMCQDCIHEKTCKECTPEFFLHDD 344
Query: 538 KCNLLEGEPREFVENSE-CIQCHPECLPQAMNITCTGRGPDNCIQCAH----YIDGPHCV 592
C+ + PR F +S C+ CH +CL C+G D+C C DG C+
Sbjct: 345 MCH--QSCPRGFYADSRHCVPCHKDCL------ECSGPKADDCELCLESSWVLYDG-LCL 395
Query: 593 KTCPAGVMGENNTLVWKYADAGHVCHLCHPNC 624
+ CPAG E T C CH +C
Sbjct: 396 EECPAGTYYEKET---------KECRDCHKSC 418
Score = 38.9 bits (89), Expect = 0.014
Identities = 44/224 (19%), Positives = 67/224 (29%), Gaps = 74/224 (33%)
Query: 183 HLGSCQKCDP-----------SCPNG----------------SCWGAGEENCQKLTKI-- 213
H +C++C P SCP G C G ++C+ +
Sbjct: 328 HEKTCKECTPEFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSW 387
Query: 214 -----ICAQQC-SGRCRGKSPSDC--CHNQCAAGCTGPRESDCLVCRKF-----RDEATC 260
+C ++C +G K +C CH C T C C+K R
Sbjct: 388 VLYDGLCLEECPAGTYYEKETKECRDCHKSCL---TCSSSGTCTTCQKGLIMNPRGSCMA 444
Query: 261 KDTCPPLMLYN------------------PTTYQMDVNPEGKYSFGATCVKKCPRNYVVT 302
+ C P ++ P Q P TCVK CP Y
Sbjct: 445 NEKCSPSEYWDEDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYAD 504
Query: 303 DHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFK 346
+ + C + C+ CEG + C+ G F+
Sbjct: 505 EDSNRCAHCHS-----------SCRTCEGRHSRQCHSCRPGWFQ 537
Score = 35.4 bits (80), Expect = 0.16
Identities = 37/133 (27%), Positives = 46/133 (34%), Gaps = 25/133 (18%)
Query: 499 CKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNL-LEGEPREFVENSECIQ 557
CKA C + C GC+ E + G CV KC G+ E EC
Sbjct: 75 CKACDSNCGS-CDQNGCYWCEEGFFLL------GGSCVRKCGPGFYGDQ----EMGECES 123
Query: 558 CHPECLPQAMNITCTGRGPDNCIQCAHYID-----GPHCVKTCPAGVMGENNTLVWKYAD 612
CH C TCTG G D C C + H KT G N ++ K
Sbjct: 124 CHRACE------TCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFW--NDILRKLQP 175
Query: 613 AGHVCHLCHPNCT 625
C C+ + T
Sbjct: 176 CHSSCKTCNGSAT 188
Score = 33.1 bits (74), Expect = 0.79
Identities = 26/78 (33%), Positives = 30/78 (38%), Gaps = 18/78 (23%)
Query: 281 PEGKYSFGATCVKKCPRNYVVTDH--------------GSCVRACGADSYEMEEDGVRKC 326
PE YS C K C N D GSCVR CG Y +E G +C
Sbjct: 65 PEKTYSEAVEC-KACDSNCGSCDQNGCYWCEEGFFLLGGSCVRKCGPGFYGDQEMG--EC 121
Query: 327 KKCEGPCRKVCNGIGIGE 344
+ C C + C G G E
Sbjct: 122 ESCHRAC-ETCTGPGHDE 138
>gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo
sapiens]
Length = 853
Score = 58.9 bits (141), Expect = 1e-08
Identities = 111/471 (23%), Positives = 166/471 (35%), Gaps = 81/471 (17%)
Query: 184 LGSCQKCDPSCPNGSCWGAGEENCQ------KLTKIICAQQCSGRCRGKSPSDC------ 231
+G C+ C +C +C G G + C +L + +C + GK +D
Sbjct: 118 MGECESCHRACE--TCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQP 175
Query: 232 CHNQCAAGCTGPRESDCLVCRK--FRDEATCKDTCPPLMLYNPTTYQMDVNPEG-KYSFG 288
CH+ C C G C C K + C +CP + + + E G
Sbjct: 176 CHSSCKT-CNGSATL-CTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAICSG 233
Query: 289 ATCVKKC---PRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEF 345
A KKC P + + G C C SY EDG+ C++C PCR C G
Sbjct: 234 ADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYA--EDGI--CERCSSPCR-TCE----GNA 284
Query: 346 KDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFL 405
+ S ++ H C + H VA +G H P + Q+ KT KE T
Sbjct: 285 TNCHSCEGGHVLHHGVCQENCPERH---VAVKG-VCKHCPEM-CQDCIHEKTCKECTPEF 339
Query: 406 LI------QAWPEN--RTDLHAFE-NLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEI 456
+ Q+ P H + + + + L + S + GL L+E
Sbjct: 340 FLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSWVLYDGL-CLEEC 398
Query: 457 SDGDVIISGNKNL--CYANTINWKKL-FGTSGQKTKIISNRGENSCKATGQV-------- 505
G K C+ + + T+ QK I++ RG SC A +
Sbjct: 399 PAGTYYEKETKECRDCHKSCLTCSSSGTCTTCQKGLIMNPRG--SCMANEKCSPSEYWDE 456
Query: 506 -------CHALCSPEGCWGPEPRDCVSC--RNVSRGRECVDKCNLLEGEPREFVENSECI 556
CH C C GP C +C ++ CV C EG + +++ C
Sbjct: 457 DAPGCKPCHVKCF--HCMGPAEDQCQTCPMNSLLLNTTCVKDCP--EGYYAD-EDSNRCA 511
Query: 557 QCHPECLPQAMNITCTGRGPDNCIQC--AHYIDGPHCVKTCPAGVMGENNT 605
CH C TC GR C C + G C+ C G +N+T
Sbjct: 512 HCHSSCR------TCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNST 556
Score = 55.1 bits (131), Expect = 2e-07
Identities = 46/166 (27%), Positives = 68/166 (40%), Gaps = 36/166 (21%)
Query: 470 CYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNV 529
C++ W +L G++ + G + +TG+ S +GC GP P DC+SC
Sbjct: 528 CHSCRPGWFQL----GKECLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRF 583
Query: 530 -----SRGRECVDKCNLLEGEPREFVENS--ECIQCHPECLPQAMNITCTGRGPDNCIQC 582
S+G EC C +VE S C +CHP C C G+G NC+ C
Sbjct: 584 FFLLRSKG-ECHRSC-----PDHYYVEQSTQTCERCHPTC------DQCKGKGALNCLSC 631
Query: 583 --AHYIDGPHCVKTCPAGV--MGENNTLVWKYADAGHVCHLCHPNC 624
++++ G C C G +GE C CH +C
Sbjct: 632 VWSYHLMGGICTSDCLVGEYRVGEGEKF---------NCEKCHESC 668
Score = 51.2 bits (121), Expect = 3e-06
Identities = 48/174 (27%), Positives = 66/174 (37%), Gaps = 27/174 (15%)
Query: 187 CQKCDPSCPNGSCWGAGEENCQKLTK--IICAQQCSGRCR-----GKSPSDC--CHNQCA 237
C C SC +C G C ++C +CR S C C+ C
Sbjct: 510 CAHCHSSCR--TCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCK 567
Query: 238 AGCTGPRESDCLVCRKF----RDEATCKDTCPPLMLYNPTTYQMD-VNP-----EGKYSF 287
GC GPR +DCL C +F R + C +CP +T + +P +GK
Sbjct: 568 -GCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGK--- 623
Query: 288 GATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIG 341
GA C +Y + G C C Y + E C+KC C + C G G
Sbjct: 624 GALNCLSCVWSYHLMG-GICTSDCLVGEYRVGEGEKFNCEKCHESCME-CKGPG 675
Score = 47.8 bits (112), Expect = 3e-05
Identities = 36/127 (28%), Positives = 50/127 (39%), Gaps = 30/127 (23%)
Query: 506 CHALCSPEGCWGPEPRDCVSCRN--VSRGRECVDKCNLLEGEPREFVENS--ECIQCHPE 561
CH+ C C G R C SCR G+EC+ +C EG + +NS C +C+
Sbjct: 513 CHSSCRT--CEGRHSRQCHSCRPGWFQLGKECLLQCR--EG---YYADNSTGRCERCNRS 565
Query: 562 CLPQAMNITCTGRGPDNCIQCAHYI----DGPHCVKTCPAGVMGENNTLVWKYADAGHVC 617
C C G P +C+ C + C ++CP E +T C
Sbjct: 566 CK------GCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQST---------QTC 610
Query: 618 HLCHPNC 624
CHP C
Sbjct: 611 ERCHPTC 617
Score = 44.7 bits (104), Expect = 3e-04
Identities = 42/152 (27%), Positives = 58/152 (38%), Gaps = 45/152 (29%)
Query: 497 NSCKATGQVCHALCSPEGCWGPE------------PRDCVSCRNVSRGRECV-------D 537
+SC+ + H +C E C PE P C C + +EC D
Sbjct: 288 HSCEGGHVLHHGVCQ-ENC--PERHVAVKGVCKHCPEMCQDCIHEKTCKECTPEFFLHDD 344
Query: 538 KCNLLEGEPREFVENSE-CIQCHPECLPQAMNITCTGRGPDNCIQCAH----YIDGPHCV 592
C+ + PR F +S C+ CH +CL C+G D+C C DG C+
Sbjct: 345 MCH--QSCPRGFYADSRHCVPCHKDCL------ECSGPKADDCELCLESSWVLYDG-LCL 395
Query: 593 KTCPAGVMGENNTLVWKYADAGHVCHLCHPNC 624
+ CPAG E T C CH +C
Sbjct: 396 EECPAGTYYEKET---------KECRDCHKSC 418
Score = 38.9 bits (89), Expect = 0.014
Identities = 44/224 (19%), Positives = 67/224 (29%), Gaps = 74/224 (33%)
Query: 183 HLGSCQKCDP-----------SCPNG----------------SCWGAGEENCQKLTKI-- 213
H +C++C P SCP G C G ++C+ +
Sbjct: 328 HEKTCKECTPEFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSW 387
Query: 214 -----ICAQQC-SGRCRGKSPSDC--CHNQCAAGCTGPRESDCLVCRKF-----RDEATC 260
+C ++C +G K +C CH C T C C+K R
Sbjct: 388 VLYDGLCLEECPAGTYYEKETKECRDCHKSCL---TCSSSGTCTTCQKGLIMNPRGSCMA 444
Query: 261 KDTCPPLMLYN------------------PTTYQMDVNPEGKYSFGATCVKKCPRNYVVT 302
+ C P ++ P Q P TCVK CP Y
Sbjct: 445 NEKCSPSEYWDEDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYAD 504
Query: 303 DHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFK 346
+ + C + C+ CEG + C+ G F+
Sbjct: 505 EDSNRCAHCHS-----------SCRTCEGRHSRQCHSCRPGWFQ 537
Score = 36.2 bits (82), Expect = 0.094
Identities = 38/136 (27%), Positives = 47/136 (34%), Gaps = 25/136 (18%)
Query: 496 ENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNL-LEGEPREFVENSE 554
E CKA C + C GC+ E + G CV KC G+ E E
Sbjct: 72 EVECKACDSNCGS-CDQNGCYWCEEGFFLL------GGSCVRKCGPGFYGDQ----EMGE 120
Query: 555 CIQCHPECLPQAMNITCTGRGPDNCIQCAHYID-----GPHCVKTCPAGVMGENNTLVWK 609
C CH C TCTG G D C C + H KT G N ++ K
Sbjct: 121 CESCHRACE------TCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFW--NDILRK 172
Query: 610 YADAGHVCHLCHPNCT 625
C C+ + T
Sbjct: 173 LQPCHSSCKTCNGSAT 188
Score = 33.5 bits (75), Expect = 0.61
Identities = 27/89 (30%), Positives = 37/89 (41%), Gaps = 14/89 (15%)
Query: 260 CKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKK----CPRNYVVTDHGSCVRACGADS 315
C TCP TY +V + S +C + C + + GSCVR CG
Sbjct: 60 CYKTCPE------KTYSEEVECKACDSNCGSCDQNGCYWCEEGFFLLG-GSCVRKCGPGF 112
Query: 316 YEMEEDGVRKCKKCEGPCRKVCNGIGIGE 344
Y +E G +C+ C C + C G G E
Sbjct: 113 YGDQEMG--ECESCHRAC-ETCTGPGHDE 138
>gi|239755070 PREDICTED: similar to proprotein convertase
subtilisin/kexin type 5 [Homo sapiens]
Length = 853
Score = 55.1 bits (131), Expect = 2e-07
Identities = 46/166 (27%), Positives = 68/166 (40%), Gaps = 36/166 (21%)
Query: 470 CYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNV 529
C++ W +L G++ + G + +TG+ S +GC GP P DC+SC
Sbjct: 528 CHSCRPGWFQL----GKECLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRF 583
Query: 530 -----SRGRECVDKCNLLEGEPREFVENS--ECIQCHPECLPQAMNITCTGRGPDNCIQC 582
S+G EC C +VE S C +CHP C C G+G NC+ C
Sbjct: 584 FFLLRSKG-ECHRSC-----PDHYYVEQSTQTCERCHPTC------DQCKGKGALNCLSC 631
Query: 583 --AHYIDGPHCVKTCPAGV--MGENNTLVWKYADAGHVCHLCHPNC 624
++++ G C C G +GE C CH +C
Sbjct: 632 VWSYHLMGGICTSDCLVGEYRVGEGEKF---------NCEKCHESC 668
Score = 51.2 bits (121), Expect = 3e-06
Identities = 48/174 (27%), Positives = 66/174 (37%), Gaps = 27/174 (15%)
Query: 187 CQKCDPSCPNGSCWGAGEENCQKLTK--IICAQQCSGRCR-----GKSPSDC--CHNQCA 237
C C SC +C G C ++C +CR S C C+ C
Sbjct: 510 CAHCHSSCR--TCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCK 567
Query: 238 AGCTGPRESDCLVCRKF----RDEATCKDTCPPLMLYNPTTYQMD-VNP-----EGKYSF 287
GC GPR +DCL C +F R + C +CP +T + +P +GK
Sbjct: 568 -GCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGK--- 623
Query: 288 GATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIG 341
GA C +Y + G C C Y + E C+KC C + C G G
Sbjct: 624 GALNCLSCVWSYHLMG-GICTSDCLVGEYRVGEGEKFNCEKCHESCME-CKGPG 675
Score = 48.5 bits (114), Expect = 2e-05
Identities = 46/174 (26%), Positives = 67/174 (38%), Gaps = 27/174 (15%)
Query: 184 LGSCQKCDPSCPNGSCWGAGEENCQ------KLTKIICAQQCSGRCRGKSPSDC------ 231
+G C+ C +C +C G G + C +L + +C + GK +D
Sbjct: 118 MGECESCHRACE--TCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQP 175
Query: 232 CHNQCAAGCTGPRESDCLVCRK--FRDEATCKDTCPPLMLYNPTTYQMDVNPEG-KYSFG 288
CH+ C C G C C K + C +CP + + + E G
Sbjct: 176 CHSSCKT-CNGSATL-CTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAICSG 233
Query: 289 ATCVKKC---PRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNG 339
A KKC P + + G C C SY EDG+ C++C PCR C G
Sbjct: 234 ADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYA--EDGI--CERCSSPCR-TCEG 282
Score = 47.8 bits (112), Expect = 3e-05
Identities = 36/127 (28%), Positives = 50/127 (39%), Gaps = 30/127 (23%)
Query: 506 CHALCSPEGCWGPEPRDCVSCRN--VSRGRECVDKCNLLEGEPREFVENS--ECIQCHPE 561
CH+ C C G R C SCR G+EC+ +C EG + +NS C +C+
Sbjct: 513 CHSSCRT--CEGRHSRQCHSCRPGWFQLGKECLLQCR--EG---YYADNSTGRCERCNRS 565
Query: 562 CLPQAMNITCTGRGPDNCIQCAHYI----DGPHCVKTCPAGVMGENNTLVWKYADAGHVC 617
C C G P +C+ C + C ++CP E +T C
Sbjct: 566 CK------GCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQST---------QTC 610
Query: 618 HLCHPNC 624
CHP C
Sbjct: 611 ERCHPTC 617
Score = 45.4 bits (106), Expect = 2e-04
Identities = 40/149 (26%), Positives = 57/149 (38%), Gaps = 39/149 (26%)
Query: 497 NSCKATGQVCHALCSP---------EGCWGPEPRDCVSCRNVSRGRECV-------DKCN 540
+SC+ + H +C EG P C C + +EC+ D C+
Sbjct: 288 HSCEGGHVLHHGVCQENCPERHVAVEGVCKHCPEMCQDCIHEKTCKECMPEFFLHDDMCH 347
Query: 541 LLEGEPREFVENSE-CIQCHPECLPQAMNITCTGRGPDNCIQCAH----YIDGPHCVKTC 595
+ PR F +S C+ CH +CL C+G D+C C DG C++ C
Sbjct: 348 --QSCPRGFYADSHHCVPCHKDCL------ECSGPKADDCELCLESSWVLYDG-LCLEEC 398
Query: 596 PAGVMGENNTLVWKYADAGHVCHLCHPNC 624
PAG E T C CH +C
Sbjct: 399 PAGTYYEKQT---------KECRDCHKSC 418
Score = 38.5 bits (88), Expect = 0.019
Identities = 41/206 (19%), Positives = 61/206 (29%), Gaps = 63/206 (30%)
Query: 190 CDPSCPNG----------------SCWGAGEENCQKLTKI-------ICAQQC-SGRCRG 225
C SCP G C G ++C+ + +C ++C +G
Sbjct: 346 CHQSCPRGFYADSHHCVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYE 405
Query: 226 KSPSDC--CHNQCAAGCTGPRESDCLVCRKF-----RDEATCKDTCPPLMLYN------- 271
K +C CH C T C C+K R + C P ++
Sbjct: 406 KQTKECRDCHKSCL---TCSSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCK 462
Query: 272 -----------PTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEE 320
P Q P TCVK CP Y + + C +
Sbjct: 463 PCHVKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHS------- 515
Query: 321 DGVRKCKKCEGPCRKVCNGIGIGEFK 346
C+ CEG + C+ G F+
Sbjct: 516 ----SCRTCEGRHSRQCHSCRPGWFQ 537
Score = 35.8 bits (81), Expect = 0.12
Identities = 37/133 (27%), Positives = 46/133 (34%), Gaps = 25/133 (18%)
Query: 499 CKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNL-LEGEPREFVENSECIQ 557
CKA C + C GC+ E + G CV KC G+ E EC
Sbjct: 75 CKACDSNCSS-CDQNGCYWCEEGFFLL------GGSCVRKCGPGFYGDQ----EMGECES 123
Query: 558 CHPECLPQAMNITCTGRGPDNCIQCAHYID-----GPHCVKTCPAGVMGENNTLVWKYAD 612
CH C TCTG G D C C + H KT G N ++ K
Sbjct: 124 CHRACE------TCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFW--NDILRKLQP 175
Query: 613 AGHVCHLCHPNCT 625
C C+ + T
Sbjct: 176 CHSSCKTCNGSAT 188
Score = 34.3 bits (77), Expect = 0.36
Identities = 41/180 (22%), Positives = 65/180 (36%), Gaps = 50/180 (27%)
Query: 189 KCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCT---GPRE 245
+C CP GS A + C++ C+ C C G + + CH+ C G G +
Sbjct: 254 RCYSKCPEGSY--AEDGICER-----CSSPCR-TCEGNATN--CHS-CEGGHVLHHGVCQ 302
Query: 246 SDCL---------------VCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGAT 290
+C +C+ E TCK+ P L++ +Q P G Y+
Sbjct: 303 ENCPERHVAVEGVCKHCPEMCQDCIHEKTCKECMPEFFLHDDMCHQS--CPRGFYADSHH 360
Query: 291 CV-----------------KKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPC 333
CV + C + V G C+ C A +Y E ++C+ C C
Sbjct: 361 CVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTY--YEKQTKECRDCHKSC 418
Score = 33.5 bits (75), Expect = 0.61
Identities = 26/78 (33%), Positives = 30/78 (38%), Gaps = 18/78 (23%)
Query: 281 PEGKYSFGATCVKKCPRNYVVTDH--------------GSCVRACGADSYEMEEDGVRKC 326
PE YS C K C N D GSCVR CG Y +E G +C
Sbjct: 65 PEKTYSEAVEC-KACDSNCSSCDQNGCYWCEEGFFLLGGSCVRKCGPGFYGDQEMG--EC 121
Query: 327 KKCEGPCRKVCNGIGIGE 344
+ C C + C G G E
Sbjct: 122 ESCHRAC-ETCTGPGHDE 138
Score = 32.0 bits (71), Expect = 1.8
Identities = 23/70 (32%), Positives = 30/70 (42%), Gaps = 8/70 (11%)
Query: 506 CHALCSPEGCWGPEPRDCVSCRNVS---RGRECVDKCNLLEGEPREFVENSECIQCHPEC 562
CH C C GP+ DC C S C+++C G E + EC CH C
Sbjct: 364 CHKDCLE--CSGPKADDCELCLESSWVLYDGLCLEECPA--GTYYE-KQTKECRDCHKSC 418
Query: 563 LPQAMNITCT 572
L + + TCT
Sbjct: 419 LTCSSSGTCT 428
>gi|20336246 proprotein convertase subtilisin/kexin type 5
preproprotein [Homo sapiens]
Length = 913
Score = 54.7 bits (130), Expect = 3e-07
Identities = 54/202 (26%), Positives = 74/202 (36%), Gaps = 56/202 (27%)
Query: 187 CQKCDPSCPNGSCWGAGEENCQKLTKIICAQQ----CSGRCRGKSPSDCCHNQCAAGCTG 242
C+KC P+C SC+G+ + C + C C S D N C C+
Sbjct: 686 CRKCAPNCE--SCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRK-CS- 741
Query: 243 PRESDCLVCRKFRDEATCKD-----------TCPPLMLYNPTTYQMDVNPEGKYSFGATC 291
+C C +F + C+D +C +N D P + F ATC
Sbjct: 742 ---ENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNG----QDCQP--CHRFCATC 792
Query: 292 VK-------KCPRNYVVTDHGSCVRACGADSY--EMEEDGVRKCKKCEGPCRKVCNGIGI 342
C Y + D G CV++C Y E+G + CKKC+ C CNG G
Sbjct: 793 AGAGADGCINCTEGYFMED-GRCVQSCSISYYFDHSSENGYKSCKKCDISC-LTCNGPG- 849
Query: 343 GEFKDSLSINATNIKHFKNCTS 364
FKNCTS
Sbjct: 850 ----------------FKNCTS 855
Score = 43.9 bits (102), Expect = 4e-04
Identities = 35/130 (26%), Positives = 46/130 (35%), Gaps = 32/130 (24%)
Query: 506 CHALCSPEGCWGPEPRDCVSCRNV-----SRGRECVDKCNLLEGEPREF-VENSECIQCH 559
C CS GC GP P C C + + R CV C P + + C +C
Sbjct: 636 CDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSC-----PPGHYHADKKRCRKCA 690
Query: 560 PECLPQAMNITCTGRGPDNCIQCAHYI----DGPHCVKTCPAGVMGENNTLVWKYADA-G 614
P C +C G D C+ C + + CV CP G Y D
Sbjct: 691 PNC------ESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDG----------SYQDTKK 734
Query: 615 HVCHLCHPNC 624
++C C NC
Sbjct: 735 NLCRKCSENC 744
Score = 42.4 bits (98), Expect = 0.001
Identities = 37/151 (24%), Positives = 55/151 (36%), Gaps = 35/151 (23%)
Query: 466 NKNLCYANTINWKKLFGTSGQ-----KTKIISNRGENSCKATGQVCHALCSPEGCWGPEP 520
+K C N + FG+ G K N NSC V H P+G +
Sbjct: 682 DKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSC-----VTHC---PDGSYQDTK 733
Query: 521 RD--------CVSCRNVSRGRECVDKCNL------LEGEPREFVENSECIQCHPECLPQA 566
++ C +C EC D +L + E + +C CH C
Sbjct: 734 KNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQDCQPCHRFCA--- 790
Query: 567 MNITCTGRGPDNCIQC--AHYIDGPHCVKTC 595
TC G G D CI C ++++ CV++C
Sbjct: 791 ---TCAGAGADGCINCTEGYFMEDGRCVQSC 818
Score = 34.3 bits (77), Expect = 0.36
Identities = 27/87 (31%), Positives = 35/87 (40%), Gaps = 21/87 (24%)
Query: 504 QVCHALCSPEGCWGPEPRDCVSCRN---VSRGRECVDKCNLLEGEPREFVENSE-----C 555
Q CH C+ C G C++C + GR CV C++ F +SE C
Sbjct: 783 QPCHRFCAT--CAGAGADGCINCTEGYFMEDGR-CVQSCSI----SYYFDHSSENGYKSC 835
Query: 556 IQCHPECLPQAMNITCTGRGPDNCIQC 582
+C CL TC G G NC C
Sbjct: 836 KKCDISCL------TCNGPGFKNCTSC 856
>gi|108773804 Fraser syndrome 1 [Homo sapiens]
Length = 4011
Score = 53.9 bits (128), Expect = 4e-07
Identities = 37/142 (26%), Positives = 51/142 (35%), Gaps = 44/142 (30%)
Query: 499 CKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRG-------------RECVDKCNLLEGE 545
CKA CH+ C C GP P C C+ G EC+ +C
Sbjct: 652 CKA----CHSSCL--ACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQC-----R 700
Query: 546 PREFVENSE-CIQCHPECLPQAMNITCTGRGPDNCIQC--AHYIDGPHCVKTCPAGVMGE 602
++E++ C CH C C G+ P NC C +H + C+ CP G +
Sbjct: 701 AHFYLESTGICEACHQSC------FRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQ 754
Query: 603 NNTLVWKYADAGHVCHLCHPNC 624
+ C CHP C
Sbjct: 755 EGS-----------CTECHPTC 765
Score = 52.8 bits (125), Expect = 1e-06
Identities = 55/200 (27%), Positives = 76/200 (38%), Gaps = 27/200 (13%)
Query: 159 VESIQWRDIVSSDFLSNMSMDFQ-NHLGSCQKCDPSCPNGSCWGAGEENCQKL--TKIIC 215
VE + I S + L+ F G C+ C SC C G NC + ++
Sbjct: 682 VEQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFR--CAGKSPHNCTDCGPSHVLL 739
Query: 216 AQQCSGRCRG---KSPSDC--CHNQCAAGCTGPRESDCLVCRKF--RDEATCKDTCPPLM 268
QC +C C CH C C GP ESDC+ C C+ +C
Sbjct: 740 DGQCLSQCPDGYFHQEGSCTECHPTCRQ-CHGPLESDCISCYPHISLTNGNCRTSCREEQ 798
Query: 269 LYNPTTYQMDVN------PEGKYSFGATCVKKCPRNYVVT-DHGSCVRACGADSYEMEED 321
N Y D + ++ G+ C++ +Y++ DH CV C + Y E
Sbjct: 799 FLNLVGYCADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGDH--CVPDCPSGYY--AER 854
Query: 322 GVRKCKKCEGPCRKVCNGIG 341
G CKKC CR C G G
Sbjct: 855 GA--CKKCHSSCR-TCQGRG 871
Score = 51.6 bits (122), Expect = 2e-06
Identities = 34/125 (27%), Positives = 45/125 (36%), Gaps = 29/125 (23%)
Query: 505 VCHALCSPEGCWGPEPRDCVSCR---NVSRGRECVDKCNLLEGEPREFVENSECIQCHPE 561
VCH C+ GCWGP + C++CR +V R C C + C C
Sbjct: 512 VCHESCA--GCWGPTEKHCLACRDPLHVLRDGGCESSCG-----KGFYNRQGTCSACDQS 564
Query: 562 CLPQAMNITCTGRGPDNCIQCAH--YIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHL 619
C G C+ C + C+ CP G YADA C +
Sbjct: 565 C-------DSCGPSSPRCLTCTEKTVLHDGKCMSECPGGY----------YADATGRCKV 607
Query: 620 CHPNC 624
CH +C
Sbjct: 608 CHNSC 612
Score = 51.6 bits (122), Expect = 2e-06
Identities = 46/174 (26%), Positives = 61/174 (35%), Gaps = 54/174 (31%)
Query: 174 SNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTK--IICAQQCSGRCRGKSPSDC 231
S+ F N G+C CD SC SC G C T+ ++ +C C G +D
Sbjct: 545 SSCGKGFYNRQGTCSACDQSC--DSC-GPSSPRCLTCTEKTVLHDGKCMSECPGGYYADA 601
Query: 232 ------CHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKY 285
CHN CA+ C+GP S C C PP L
Sbjct: 602 TGRCKVCHNSCAS-CSGPTPSHCTAC------------SPPKALRQ-------------- 634
Query: 286 SFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNG 339
C+ +C + +DHG C +AC + C C GP C G
Sbjct: 635 ---GHCLPRCGEGF-YSDHGVC-KACHS-----------SCLACMGPAPSHCTG 672
Score = 50.8 bits (120), Expect = 4e-06
Identities = 43/135 (31%), Positives = 56/135 (41%), Gaps = 31/135 (22%)
Query: 496 ENSCKATGQVCHALCSPEGCWGPEPRDCVSCR---NVSRGRECVDKCNLLEGEPREFVEN 552
E SC CH C C GP DC+SC +++ G C C E +
Sbjct: 755 EGSCTE----CHPTCRQ--CHGPLESDCISCYPHISLTNGN-CRTSCR----EEQFLNLV 803
Query: 553 SECIQCHPECLPQAMNITCTGRGPDNCIQC--AHYID-GPHCVKTCPAGVMGENNTLVWK 609
C CH C A ++ TG C++C AHY+ G HCV CP+G
Sbjct: 804 GYCADCHHLCQHCAADLHNTG---SICLRCQNAHYLLLGDHCVPDCPSGY---------- 850
Query: 610 YADAGHVCHLCHPNC 624
YA+ G C CH +C
Sbjct: 851 YAERG-ACKKCHSSC 864
Score = 49.7 bits (117), Expect = 8e-06
Identities = 37/131 (28%), Positives = 53/131 (40%), Gaps = 20/131 (15%)
Query: 501 ATGQ--VCHALCSPEGCWGPEPRDCVSCR--NVSRGRECVDKCNLLEGEPREFVENSECI 556
ATG+ VCH C+ C GP P C +C R C+ +C EG + ++ C
Sbjct: 601 ATGRCKVCHNSCA--SCSGPTPSHCTACSPPKALRQGHCLPRCG--EG---FYSDHGVCK 653
Query: 557 QCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGV-MGE--NNTLVWKYADA 613
CH CL C G P +C C +G + G+ GE Y ++
Sbjct: 654 ACHSSCL------ACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLES 707
Query: 614 GHVCHLCHPNC 624
+C CH +C
Sbjct: 708 TGICEACHQSC 718
Score = 46.6 bits (109), Expect = 7e-05
Identities = 32/108 (29%), Positives = 40/108 (37%), Gaps = 27/108 (25%)
Query: 523 CVSCRNVSR---GRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNC 579
C+ C+N G CV C + E C +CH C TC GRGP +C
Sbjct: 827 CLRCQNAHYLLLGDHCVPDC-----PSGYYAERGACKKCHSSCR------TCQGRGPFSC 875
Query: 580 IQCAHYIDGPH---CVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNC 624
C + H C TC G Y D HVC C+ +C
Sbjct: 876 SSCDTNLVLSHTGTCSTTCFPG----------HYLDDNHVCQPCNTHC 913
Score = 45.1 bits (105), Expect = 2e-04
Identities = 43/180 (23%), Positives = 58/180 (32%), Gaps = 50/180 (27%)
Query: 187 CQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRC-----RGKSPSDCCHNQCAAGCT 241
C C P C +C E + + ++ QC C + + CH CA GC
Sbjct: 465 CLACQPQC--STCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDRHSCAVCHESCA-GCW 521
Query: 242 GPRESDCLVCRK------------------FRDEATCK------DTCPPLMLYNPTTYQM 277
GP E CL CR + + TC D+C P T +
Sbjct: 522 GPTEKHCLACRDPLHVLRDGGCESSCGKGFYNRQGTCSACDQSCDSCGPSSPRCLTCTEK 581
Query: 278 DVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVC 337
V +GK C+ +CP Y G C + C C C GP C
Sbjct: 582 TVLHDGK------CMSECPGGYYADATGRC-KVCH-----------NSCASCSGPTPSHC 623
Score = 43.9 bits (102), Expect = 4e-04
Identities = 47/182 (25%), Positives = 63/182 (34%), Gaps = 37/182 (20%)
Query: 185 GSCQKCDPSCPNGSCWGAGEENCQKLT--KIICAQQCSGRCRGKSPSD-----CCHNQCA 237
G C+ C SC SC G +C + K + C RC SD CH+ C
Sbjct: 603 GRCKVCHNSC--ASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSDHGVCKACHSSCL 660
Query: 238 AGCTGPRESDCLVCRKFRD-------------EATCKDTCPPLMLYNPT-----TYQMDV 279
A C GP S C C+K + C C T +Q
Sbjct: 661 A-CMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCF 719
Query: 280 NPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRK----CKKCEGPCRK 335
GK T C ++V+ D G C+ C D Y +E + C++C GP
Sbjct: 720 RCAGKSPHNCT---DCGPSHVLLD-GQCLSQC-PDGYFHQEGSCTECHPTCRQCHGPLES 774
Query: 336 VC 337
C
Sbjct: 775 DC 776
Score = 42.4 bits (98), Expect = 0.001
Identities = 39/159 (24%), Positives = 61/159 (38%), Gaps = 46/159 (28%)
Query: 182 NHLGSCQKCDPSCPNGSCWG-AGEENCQKLTKIICAQQCSGR-CRGKSPSDCCHNQC--- 236
NH+ CQ C+ C GSC A +C+ K++ +C C + D N C
Sbjct: 903 NHV--CQPCNTHC--GSCDSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKEC 958
Query: 237 ---AAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVK 293
+ C+GP ++DCL C +G CV+
Sbjct: 959 DWSCSACSGPLKTDCLQCM-----------------------------DGYVLQDGACVE 989
Query: 294 KCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGP 332
+C ++ D G C DSY ++ G +C +C+GP
Sbjct: 990 QCLSSFY-QDSG----LCKCDSYCLQCQGPHECTRCKGP 1023
Score = 36.6 bits (83), Expect = 0.072
Identities = 21/73 (28%), Positives = 31/73 (42%), Gaps = 21/73 (28%)
Query: 556 IQCHPECLPQAMNITCTGRGPDNCIQC---AHYIDGPHCVKTCPAGVMGENNTLVWKYAD 612
+ CHP+CL TC+ + PD+C C + CV +C G +
Sbjct: 419 VHCHPDCL------TCS-QSPDHCDLCQDPTKLLQNGWCVHSCGLG-----------FYQ 460
Query: 613 AGHVCHLCHPNCT 625
AG +C C P C+
Sbjct: 461 AGSLCLACQPQCS 473
Score = 33.1 bits (74), Expect = 0.79
Identities = 29/114 (25%), Positives = 44/114 (38%), Gaps = 32/114 (28%)
Query: 497 NSCKATGQVCHALCSPEGCWGPEPRDCVSCRN--VSRGRECVDKCNLLEGEPREFVE-NS 553
N+CK C A C GP DC+ C + V + CV++C + + +S
Sbjct: 953 NTCKECDWSCSA------CSGPLKTDCLQCMDGYVLQDGACVEQCLSSFYQDSGLCKCDS 1006
Query: 554 ECIQCH----------PECLPQAMNITCTGRG-------------PDNCIQCAH 584
C+QC P L +A + G+G P C+QC+H
Sbjct: 1007 YCLQCQGPHECTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQCSH 1060
Score = 31.2 bits (69), Expect = 3.0
Identities = 51/190 (26%), Positives = 65/190 (34%), Gaps = 35/190 (18%)
Query: 190 CDPS-CPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCH-NQCAAGCTGPRESD 247
C P+ C N C E Q I A QC C ++P C H + T S
Sbjct: 58 CKPAVCRNPQCAFEKGEVLQ-----IAANQCCPECVLRTPGSCHHEKKIHEHGTEWASSP 112
Query: 248 CLVCRKFRDEATC-KDTCPPLM--------------------LYNPTTYQMDVNPEGKYS 286
C VC E C CPPL L P +Y+ V +G+
Sbjct: 113 CSVCSCNHGEVRCTPQPCPPLSCGHQELAFIPEGSCCPVCVGLGKPCSYEGHVFQDGEDW 172
Query: 287 FGATCVKKCPRNYVVTDHGSCVRA-CGADSYEMEEDGVRKCKKCEGPC-RKVCNGIG-IG 343
+ C K RN V C A C +E VR KC C + C+ G +
Sbjct: 173 RLSRCAKCLCRNGV----AQCFTAQCQPLFCNQDETVVRVPGKCCPQCSARSCSAAGQVY 228
Query: 344 EFKDSLSINA 353
E + S NA
Sbjct: 229 EHGEQWSENA 238
>gi|122937343 platelet endothelial aggregation receptor 1 [Homo
sapiens]
Length = 1037
Score = 42.0 bits (97), Expect = 0.002
Identities = 44/150 (29%), Positives = 51/150 (34%), Gaps = 46/150 (30%)
Query: 495 GENSCKA--TGQVCHALCSPEGCWG----------------PEPRDCVSCRNVSRGRECV 536
G C+A G CH C PEG WG PE +CV C RG C
Sbjct: 550 GRCQCQAGWMGARCHLSC-PEGLWGVNCSNTCTCKNGGTCLPENGNCV-CAPGFRGPSCQ 607
Query: 537 DKCNLLEGEPREFVENSECIQC----HPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCV 592
C +P + C+ C H C P N TC C GP C
Sbjct: 608 RSC-----QPGRY--GKRCVPCKCANHSFCHPS--NGTC---------YCLAGWTGPDCS 649
Query: 593 KTCPAGVMGENNTLVWKYADAGHVCHLCHP 622
+ CP G GEN + G CHP
Sbjct: 650 QPCPPGHWGENCAQTCQCHHGG----TCHP 675
Score = 32.3 bits (72), Expect = 1.4
Identities = 34/115 (29%), Positives = 39/115 (33%), Gaps = 27/115 (23%)
Query: 502 TGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPRE------------F 549
TG C +LC P+ +G SC N +C EG R F
Sbjct: 430 TGPHCASLCPPD-TYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGF 488
Query: 550 VENSECIQCHPE--CLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGE 602
N+ C QC E C PQ TCT G HC CP G GE
Sbjct: 489 SCNASC-QCAHEAVCSPQTGACTCTPGW-----------HGAHCQLPCPKGQFGE 531
Score = 32.0 bits (71), Expect = 1.8
Identities = 29/127 (22%), Positives = 41/127 (32%), Gaps = 34/127 (26%)
Query: 510 CSPEGCWGPEPRDCVSCRNVSRGRECVDKCNL-----LEGEPREFVENSECIQCHP---- 560
C+P+ P C+ C + G C D+ L + + + CHP
Sbjct: 321 CAPDARCFPANGACL-CEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGE 379
Query: 561 -ECLPQAMNITCTGRGP---------DNCI--------------QCAHYIDGPHCVKTCP 596
CLP + C P ++C+ QCA GPHC CP
Sbjct: 380 CSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCP 439
Query: 597 AGVMGEN 603
G N
Sbjct: 440 PDTYGVN 446
>gi|28626521 zinc finger, NFX1-type containing 1 [Homo sapiens]
Length = 1918
Score = 40.4 bits (93), Expect = 0.005
Identities = 35/128 (27%), Positives = 49/128 (38%), Gaps = 18/128 (14%)
Query: 185 GSCQKCDPSCPNGSCWGAGE----ENCQKLTK--IICAQQCSGRCRGKSP-------SDC 231
G+ C CP GSC E E CQ+ K +IC+ +C C G+ P + C
Sbjct: 1436 GTILDCGHPCP-GSCHSCFEGRFHERCQQPCKRLLICSHKCQEPCIGECPPCQRTCQNRC 1494
Query: 232 CHNQC----AAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSF 287
H+QC C+ E C+ ++ C + C Y P T +
Sbjct: 1495 VHSQCKKKCGELCSPCVEPCVWRCQHYQCTKLCSEPCNRPPCYVPCTKLLVCGHPCIGLC 1554
Query: 288 GATCVKKC 295
G C KKC
Sbjct: 1555 GEPCPKKC 1562
Score = 30.0 bits (66), Expect = 6.7
Identities = 16/60 (26%), Positives = 24/60 (40%), Gaps = 9/60 (15%)
Query: 184 LGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGP 243
+G C C +C N ++ C +L C + C RC+ H QC C+ P
Sbjct: 1480 IGECPPCQRTCQNRCVHSQCKKKCGELCS-PCVEPCVWRCQ--------HYQCTKLCSEP 1530
>gi|33598931 scavenger receptor class F, member 1 isoform 3
precursor [Homo sapiens]
Length = 569
Score = 37.4 bits (85), Expect = 0.042
Identities = 42/183 (22%), Positives = 51/183 (27%), Gaps = 67/183 (36%)
Query: 499 CKATGQVCH-----ALCSPEGCWGPEPR---DCVS------------------------C 526
C G C C P G WGPE + +CV C
Sbjct: 194 CNCHGSPCEQDSGRCACRP-GWWGPECQQQCECVRGRCSAASGECTCPPGFRGARCELPC 252
Query: 527 RNVSRGRECVDKCNLLEGEPREFVENSECIQCHP---------ECLPQAMNITCTGRGPD 577
S G +C C + + C C P CLP +C + P
Sbjct: 253 PAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPH 312
Query: 578 ------------NCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCT 625
+C +C GP C CP G GE D G C P C
Sbjct: 313 CRHGEACEPDTGHCQRCDPGWLGPRCEDPCPTGTFGE---------DCGSTC----PTCV 359
Query: 626 YGS 628
GS
Sbjct: 360 QGS 362
Score = 37.0 bits (84), Expect = 0.055
Identities = 34/118 (28%), Positives = 47/118 (39%), Gaps = 10/118 (8%)
Query: 185 GSCQKCDPSCPNGSCWGAGEENCQKLT-KIICAQQCSGRCRGKS-PSDCCHNQ-CAAGCT 241
GSC+ C+P C ++ C T C QQC G++ D H Q C G
Sbjct: 279 GSCESCEPGWNGTQC----QQPCLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWL 334
Query: 242 GPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNY 299
GPR D F ++ C TCP + + T D Y +G +C CP +
Sbjct: 335 GPRCEDPCPTGTFGED--CGSTCPTCVQGSCDTVTGDCVCSAGY-WGPSCNASCPAGF 389
Score = 36.6 bits (83), Expect = 0.072
Identities = 43/147 (29%), Positives = 60/147 (40%), Gaps = 20/147 (13%)
Query: 482 GTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNL 541
GT Q+ + GE SC+ Q C E C P+ C C G C D C
Sbjct: 290 GTQCQQPCLPGTFGE-SCE---QQCPHCRHGEAC-EPDTGHCQRCDPGWLGPRCEDPC-- 342
Query: 542 LEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMG 601
F E +C P C+ + + T TG +C+ A Y GP C +CPAG G
Sbjct: 343 ---PTGTFGE--DCGSTCPTCVQGSCD-TVTG----DCVCSAGYW-GPSCNASCPAGFHG 391
Query: 602 ENNTLVWKYADAGHVCHLCHPNCTYGS 628
N ++ + + +CH +C GS
Sbjct: 392 NNCSVPCECPEG--LCHPVSGSCQPGS 416
Score = 32.3 bits (72), Expect = 1.4
Identities = 20/56 (35%), Positives = 23/56 (41%), Gaps = 13/56 (23%)
Query: 287 FGATCVKKCPRNYVVTD---------HGSCVRACGADSYEMEEDGVRKCKKCEGPC 333
FGA C +CP Y D HG C A GA + + G R CE PC
Sbjct: 82 FGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGAR----CEFPC 133
Score = 30.0 bits (66), Expect = 6.7
Identities = 31/135 (22%), Positives = 46/135 (34%), Gaps = 22/135 (16%)
Query: 503 GQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSEC------- 555
G+ C C+ G + +CR G EC +C + G R + EC
Sbjct: 187 GRRCSFRCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVRG--RCSAASGECTCPPGFR 244
Query: 556 -IQCHPECLPQAMNITCT---GR-------GPD--NCIQCAHYIDGPHCVKTCPAGVMGE 602
+C C + + C GR PD +C C +G C + C G GE
Sbjct: 245 GARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGE 304
Query: 603 NNTLVWKYADAGHVC 617
+ + G C
Sbjct: 305 SCEQQCPHCRHGEAC 319
Score = 29.6 bits (65), Expect = 8.8
Identities = 27/110 (24%), Positives = 38/110 (34%), Gaps = 25/110 (22%)
Query: 185 GSCQKCDPS---------CPNG--------SCWGAGEENCQKLT-KIICAQQCSG-RCRG 225
G CQ+CDP CP G +C + +C +T +C+ G C
Sbjct: 324 GHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQGSCDTVTGDCVCSAGYWGPSCNA 383
Query: 226 KSPSDCCHNQCAAGCTGPR------ESDCLVCRKFRDEATCKDTCPPLML 269
P+ N C+ C P C RD A + PL+L
Sbjct: 384 SCPAGFHGNNCSVPCECPEGLCHPVSGSCQPGSGSRDTALIAGSLVPLLL 433
>gi|33598929 scavenger receptor class F, member 1 isoform 1
precursor [Homo sapiens]
Length = 830
Score = 37.4 bits (85), Expect = 0.042
Identities = 42/183 (22%), Positives = 51/183 (27%), Gaps = 67/183 (36%)
Query: 499 CKATGQVCH-----ALCSPEGCWGPEPR---DCVS------------------------C 526
C G C C P G WGPE + +CV C
Sbjct: 194 CNCHGSPCEQDSGRCACRP-GWWGPECQQQCECVRGRCSAASGECTCPPGFRGARCELPC 252
Query: 527 RNVSRGRECVDKCNLLEGEPREFVENSECIQCHP---------ECLPQAMNITCTGRGPD 577
S G +C C + + C C P CLP +C + P
Sbjct: 253 PAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPH 312
Query: 578 ------------NCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCT 625
+C +C GP C CP G GE D G C P C
Sbjct: 313 CRHGEACEPDTGHCQRCDPGWLGPRCEDPCPTGTFGE---------DCGSTC----PTCV 359
Query: 626 YGS 628
GS
Sbjct: 360 QGS 362
Score = 37.0 bits (84), Expect = 0.055
Identities = 34/118 (28%), Positives = 47/118 (39%), Gaps = 10/118 (8%)
Query: 185 GSCQKCDPSCPNGSCWGAGEENCQKLT-KIICAQQCSGRCRGKS-PSDCCHNQ-CAAGCT 241
GSC+ C+P C ++ C T C QQC G++ D H Q C G
Sbjct: 279 GSCESCEPGWNGTQC----QQPCLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWL 334
Query: 242 GPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNY 299
GPR D F ++ C TCP + + T D Y +G +C CP +
Sbjct: 335 GPRCEDPCPTGTFGED--CGSTCPTCVQGSCDTVTGDCVCSAGY-WGPSCNASCPAGF 389
Score = 36.6 bits (83), Expect = 0.072
Identities = 43/147 (29%), Positives = 60/147 (40%), Gaps = 20/147 (13%)
Query: 482 GTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNL 541
GT Q+ + GE SC+ Q C E C P+ C C G C D C
Sbjct: 290 GTQCQQPCLPGTFGE-SCE---QQCPHCRHGEAC-EPDTGHCQRCDPGWLGPRCEDPC-- 342
Query: 542 LEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMG 601
F E +C P C+ + + T TG +C+ A Y GP C +CPAG G
Sbjct: 343 ---PTGTFGE--DCGSTCPTCVQGSCD-TVTG----DCVCSAGYW-GPSCNASCPAGFHG 391
Query: 602 ENNTLVWKYADAGHVCHLCHPNCTYGS 628
N ++ + + +CH +C GS
Sbjct: 392 NNCSVPCECPEG--LCHPVSGSCQPGS 416
Score = 32.3 bits (72), Expect = 1.4
Identities = 20/56 (35%), Positives = 23/56 (41%), Gaps = 13/56 (23%)
Query: 287 FGATCVKKCPRNYVVTD---------HGSCVRACGADSYEMEEDGVRKCKKCEGPC 333
FGA C +CP Y D HG C A GA + + G R CE PC
Sbjct: 82 FGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGAR----CEFPC 133
Score = 30.0 bits (66), Expect = 6.7
Identities = 31/135 (22%), Positives = 46/135 (34%), Gaps = 22/135 (16%)
Query: 503 GQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSEC------- 555
G+ C C+ G + +CR G EC +C + G R + EC
Sbjct: 187 GRRCSFRCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVRG--RCSAASGECTCPPGFR 244
Query: 556 -IQCHPECLPQAMNITCT---GR-------GPD--NCIQCAHYIDGPHCVKTCPAGVMGE 602
+C C + + C GR PD +C C +G C + C G GE
Sbjct: 245 GARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGE 304
Query: 603 NNTLVWKYADAGHVC 617
+ + G C
Sbjct: 305 SCEQQCPHCRHGEAC 319
Score = 29.6 bits (65), Expect = 8.8
Identities = 27/110 (24%), Positives = 38/110 (34%), Gaps = 25/110 (22%)
Query: 185 GSCQKCDPS---------CPNG--------SCWGAGEENCQKLT-KIICAQQCSG-RCRG 225
G CQ+CDP CP G +C + +C +T +C+ G C
Sbjct: 324 GHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQGSCDTVTGDCVCSAGYWGPSCNA 383
Query: 226 KSPSDCCHNQCAAGCTGPR------ESDCLVCRKFRDEATCKDTCPPLML 269
P+ N C+ C P C RD A + PL+L
Sbjct: 384 SCPAGFHGNNCSVPCECPEGLCHPVSGSCQPGSGSRDTALIAGSLVPLLL 433
>gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens]
Length = 763
Score = 37.4 bits (85), Expect = 0.042
Identities = 31/131 (23%), Positives = 51/131 (38%), Gaps = 23/131 (17%)
Query: 206 NCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCP 265
NC + I+ QC CRG HN CA GP+ + C+ + +ATC+
Sbjct: 372 NCSEKDHILPENQCCRVCRG-------HNFCA---EGPKCGENSECKNWNTKATCECKSG 421
Query: 266 PLMLYNPTTYQMDVNP-EGKYSF---GATCVK-------KCPRNYVVTDHGSCVR--ACG 312
+ + + Y D++ K + CV C Y+ D SC CG
Sbjct: 422 YISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECG 481
Query: 313 ADSYEMEEDGV 323
+ + +E+ +
Sbjct: 482 SGQHNCDENAI 492
>gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens]
Length = 810
Score = 37.4 bits (85), Expect = 0.042
Identities = 31/131 (23%), Positives = 51/131 (38%), Gaps = 23/131 (17%)
Query: 206 NCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCP 265
NC + I+ QC CRG HN CA GP+ + C+ + +ATC+
Sbjct: 372 NCSEKDHILPENQCCRVCRG-------HNFCA---EGPKCGENSECKNWNTKATCECKSG 421
Query: 266 PLMLYNPTTYQMDVNP-EGKYSF---GATCVK-------KCPRNYVVTDHGSCVR--ACG 312
+ + + Y D++ K + CV C Y+ D SC CG
Sbjct: 422 YISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECG 481
Query: 313 ADSYEMEEDGV 323
+ + +E+ +
Sbjct: 482 SGQHNCDENAI 492
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 37.4 bits (85), Expect = 0.042
Identities = 37/148 (25%), Positives = 55/148 (37%), Gaps = 28/148 (18%)
Query: 182 NHLGSCQKCDPSCPNGSCWGA-----GEENC-QKLTKIICAQQCSGRCRGKSPSDCCHNQ 235
N +CQ +CPN C G+++C ++ C C+ S C
Sbjct: 1144 NSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTA-----SQFKCASGD 1198
Query: 236 CAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYN------------PTTYQMDVNPE- 282
G T R C DEA C T PP M ++ P ++ D +P+
Sbjct: 1199 KCIGVTN-RCDGVFDCSDNSDEAGCP-TRPPGMCHSDEFQCQEDGICIPNFWECDGHPDC 1256
Query: 283 --GKYSFGATCVKKCPRNYVVTDHGSCV 308
G A K CP +Y D+G+C+
Sbjct: 1257 LYGSDEHNACVPKTCPSSYFHCDNGNCI 1284
Score = 31.2 bits (69), Expect = 3.0
Identities = 46/195 (23%), Positives = 62/195 (31%), Gaps = 52/195 (26%)
Query: 186 SCQKCDPSCPNGSCW--------------GAGEENCQKLT--KIIC--------AQQCSG 221
+C +C NG C GA E +CQ T ++ C +Q+C
Sbjct: 107 TCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDW 166
Query: 222 RCRGKSPSD-------CCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTT 274
+ + SD C HN+ + G G VC D C+D PT
Sbjct: 167 KVDCRDSSDEINCTEICLHNEFSCG-NGECIPRAYVCDHDND---CQDGSDEHACNYPTC 222
Query: 275 YQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPC- 333
G Y F + +N+V C D E V KC E C
Sbjct: 223 --------GGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCP 274
Query: 334 --------RKVCNGI 340
KVC+GI
Sbjct: 275 ESGRCISIYKVCDGI 289
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.440
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,241,803
Number of Sequences: 37866
Number of extensions: 1381174
Number of successful extensions: 3632
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 28
Number of HSP's successfully gapped in prelim test: 114
Number of HSP's that attempted gapping in prelim test: 3024
Number of HSP's gapped (non-prelim): 483
length of query: 628
length of database: 18,247,518
effective HSP length: 108
effective length of query: 520
effective length of database: 14,157,990
effective search space: 7362154800
effective search space used: 7362154800
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.