Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 40217823
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40217823 SLIT and NTRK-like family, member 5 [Homo sapiens]
(958 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40217823 SLIT and NTRK-like family, member 5 [Homo sapiens] 1957 0.0
gi|221136985 SLIT and NTRK-like family, member 2 [Homo sapiens] 799 0.0
gi|221136981 SLIT and NTRK-like family, member 2 [Homo sapiens] 799 0.0
gi|221136977 SLIT and NTRK-like family, member 2 [Homo sapiens] 799 0.0
gi|221136973 SLIT and NTRK-like family, member 2 [Homo sapiens] 799 0.0
gi|221136969 SLIT and NTRK-like family, member 2 [Homo sapiens] 799 0.0
gi|221136965 SLIT and NTRK-like family, member 2 [Homo sapiens] 799 0.0
gi|221136961 SLIT and NTRK-like family, member 2 [Homo sapiens] 799 0.0
gi|221136957 SLIT and NTRK-like family, member 2 [Homo sapiens] 799 0.0
gi|33504581 SLIT and NTRK-like family, member 2 [Homo sapiens] 799 0.0
gi|40217820 slit and trk like 3 protein [Homo sapiens] 694 0.0
gi|27436867 slit and trk like 4 protein [Homo sapiens] 680 0.0
gi|40217825 slit and trk like 6 [Homo sapiens] 625 e-179
gi|40217817 slit and trk like 1 protein [Homo sapiens] 519 e-147
gi|188528675 slit homolog 1 [Homo sapiens] 117 4e-26
gi|4759146 slit homolog 2 [Homo sapiens] 114 3e-25
gi|11321571 slit homolog 3 [Homo sapiens] 111 3e-24
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 107 5e-23
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 107 5e-23
gi|109150416 peroxidasin [Homo sapiens] 100 7e-21
gi|198041768 synleurin [Homo sapiens] 100 1e-20
gi|38202222 fibronectin leucine rich transmembrane protein 3 pre... 99 1e-20
gi|7019383 fibronectin leucine rich transmembrane protein 3 prec... 99 1e-20
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 99 1e-20
gi|34577057 fibronectin leucine rich transmembrane protein 1 [Ho... 97 6e-20
gi|10190722 leucine-rich repeats and transmembrane domains 1 [Ho... 96 1e-19
gi|31542244 leucine rich repeat and fibronectin type III domain ... 94 5e-19
gi|13194201 reticulon 4 receptor precursor [Homo sapiens] 94 6e-19
gi|13375646 leucine rich repeat and fibronectin type III domain ... 93 1e-18
gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho... 90 1e-17
>gi|40217823 SLIT and NTRK-like family, member 5 [Homo sapiens]
Length = 958
Score = 1957 bits (5070), Expect = 0.0
Identities = 958/958 (100%), Positives = 958/958 (100%)
Query: 1 MHTCCPPVTLEQDLHRKMHSWMLQTLAFAVTSLVLSCAETIDYYGEICDNACPCEEKDGI 60
MHTCCPPVTLEQDLHRKMHSWMLQTLAFAVTSLVLSCAETIDYYGEICDNACPCEEKDGI
Sbjct: 1 MHTCCPPVTLEQDLHRKMHSWMLQTLAFAVTSLVLSCAETIDYYGEICDNACPCEEKDGI 60
Query: 61 LTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDI 120
LTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDI
Sbjct: 61 LTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDI 120
Query: 121 ETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQ 180
ETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQ
Sbjct: 121 ETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQ 180
Query: 181 VLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMDKVVELQLEENPWNCS 240
VLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMDKVVELQLEENPWNCS
Sbjct: 181 VLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMDKVVELQLEENPWNCS 240
Query: 241 CELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPRRLISDYEMRPQTPL 300
CELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPRRLISDYEMRPQTPL
Sbjct: 241 CELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPRRLISDYEMRPQTPL 300
Query: 301 STTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQPSKDLGYSNYGP 360
STTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQPSKDLGYSNYGP
Sbjct: 301 STTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQPSKDLGYSNYGP 360
Query: 361 SIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENY 420
SIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENY
Sbjct: 361 SIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENY 420
Query: 421 IAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGL 480
IAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGL
Sbjct: 421 IAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGL 480
Query: 481 QSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLRLNLRSNHF 540
QSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLRLNLRSNHF
Sbjct: 481 QSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLRLNLRSNHF 540
Query: 541 TSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPKKFAE 600
TSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPKKFAE
Sbjct: 541 TSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPKKFAE 600
Query: 601 TDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLNSTGAPASLGAGGGASS 660
TDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLNSTGAPASLGAGGGASS
Sbjct: 601 TDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLNSTGAPASLGAGGGASS 660
Query: 661 VPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDHTSTNNSDVSSFNMQYSVYGGG 720
VPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDHTSTNNSDVSSFNMQYSVYGGG
Sbjct: 661 VPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDHTSTNNSDVSSFNMQYSVYGGG 720
Query: 721 GGTGGHPHAHVHHRGPALPKVKTPAGHVYEYIPHPLGHMCKNPIYRSREGNSVEDYKDLH 780
GGTGGHPHAHVHHRGPALPKVKTPAGHVYEYIPHPLGHMCKNPIYRSREGNSVEDYKDLH
Sbjct: 721 GGTGGHPHAHVHHRGPALPKVKTPAGHVYEYIPHPLGHMCKNPIYRSREGNSVEDYKDLH 780
Query: 781 ELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGEEERRESHHLRSPAYSVSTIEP 840
ELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGEEERRESHHLRSPAYSVSTIEP
Sbjct: 781 ELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGEEERRESHHLRSPAYSVSTIEP 840
Query: 841 REDLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPKFPCSPAAYTFSPNYDLRRPHQ 900
REDLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPKFPCSPAAYTFSPNYDLRRPHQ
Sbjct: 841 REDLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPKFPCSPAAYTFSPNYDLRRPHQ 900
Query: 901 YLHPGAGDSRLREPVLYSPPSAVFVEPNRNEYLELKAKLNVEPDYLEVLEKQTTFSQF 958
YLHPGAGDSRLREPVLYSPPSAVFVEPNRNEYLELKAKLNVEPDYLEVLEKQTTFSQF
Sbjct: 901 YLHPGAGDSRLREPVLYSPPSAVFVEPNRNEYLELKAKLNVEPDYLEVLEKQTTFSQF 958
>gi|221136985 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 799 bits (2063), Expect = 0.0
Identities = 440/918 (47%), Positives = 584/918 (63%), Gaps = 106/918 (11%)
Query: 46 EICDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYT 105
+IC C CEEK+ +L ++CEN+G ++S + PP++ IY L L+GNLL RLYPNEFVNY+
Sbjct: 27 DICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYS 86
Query: 106 GASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYI 165
A LHLG+N +Q+I TGAF GL+ L+RLHLNNNKLE+LR+DTFLGLE+LEYLQ DYNYI
Sbjct: 87 NAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYI 146
Query: 166 SVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMD 225
S IE AF KL+ L+VLILNDNLL SLP+N+FRFV LTHLDLRGNRLK++P+ G+L+H+
Sbjct: 147 SAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMPFAGVLEHIG 206
Query: 226 KVVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCP 285
++E+QLEENPWNC+C+L+ LK WLD+I+ VG++VCETPFRLHG+D+ ++++Q+LCP
Sbjct: 207 GIMEIQLEENPWNCTCDLLPLKAWLDTIT--VFVGEIVCETPFRLHGKDVTQLTRQDLCP 264
Query: 286 RRLISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPT 345
R+ SD R H T + A+ P + PK +R P K R RPT
Sbjct: 265 RKSASDSSQRGS---------HADTHVQRLSPTMNPALN--PTRAPKASRPP-KMRNRPT 312
Query: 346 SRQP-SKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAEL 404
R SKD ++GP + YQTKSPVPL CP++C C Q SD GLNVNCQERK +I++L
Sbjct: 313 PRVTVSKDR--QSFGPIMVYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDL 370
Query: 405 QPKPYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYL 464
QPKP +PKK+YLT NY+ V + D LE + LDLLHLGNNRI++IQ+ AF +LT+LRRLYL
Sbjct: 371 QPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYL 430
Query: 465 NGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGV 524
NGN +E L P +F GLQSLQYL+L+YN+I+EI+ TFD + NLQLLFLNNNLL+++P +
Sbjct: 431 NGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNI 490
Query: 525 FSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVG 584
F G L RLNLR+NHF+ LPV GVLDQL + IQIDL +NPWDCTCDI+G+K W E
Sbjct: 491 FGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSP 550
Query: 585 VLVDEVICKAPKKFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLN 644
V+++EV C++P K A ++ + E +CPD ++ T + +
Sbjct: 551 VIINEVTCESPAKHAGEILKFLGREAICPDSPNLSDGTVLSMN----------------H 594
Query: 645 STGAPASLGAGGGA-----SSVPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDH 699
+T P SL + + VPLSVLIL LL+VFI+SV AGLFV V+KRRK S
Sbjct: 595 NTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPSVP 654
Query: 700 TSTNNSDVSSFNMQYSVYGGGGGTGGHPHAHVHHRGPALPKVKTPAGHVYEYIPHPLGHM 759
+TNN DVSSF +QY Y + H + GHVY YIP P+G M
Sbjct: 655 RNTNNLDVSSFQLQYGSY----------NTETHDK---------TDGHVYNYIPPPVGQM 695
Query: 760 CKNPIYRSREGNSVEDYKDLHELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGE 819
C+NPIY +EG+ V Y++L E S +L+++++ P
Sbjct: 696 CQNPIYMQKEGDPVAYYRNLQEF-----SYSNLEEKKEEP-------------------- 730
Query: 820 EERRESHHLRSPAYSVSTIEPREDLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPK 879
+PAY++S E E +P ++ + Y+ I E K + L Y
Sbjct: 731 ---------ATPAYTISATELLEKQATP-REPELLYQNIAERVKELPSA----GLVHYNF 776
Query: 880 FPCSPAAYTFSPNYDLRRPHQYLHPGAGDSRLREPVLYSPPSAVFVEPNRNEYLELKAKL 939
C+ F+P+Y+ RR +Q R+ + VLY P FV ++ + L+AK
Sbjct: 777 --CTLPKRQFAPSYESRRQNQ--------DRINKTVLYGTPRKCFVGQSKPNHPLLQAKP 826
Query: 940 NVEPDYLEVLEKQTTFSQ 957
EPDYLEVLEKQT SQ
Sbjct: 827 QSEPDYLEVLEKQTAISQ 844
>gi|221136981 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 799 bits (2063), Expect = 0.0
Identities = 440/918 (47%), Positives = 584/918 (63%), Gaps = 106/918 (11%)
Query: 46 EICDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYT 105
+IC C CEEK+ +L ++CEN+G ++S + PP++ IY L L+GNLL RLYPNEFVNY+
Sbjct: 27 DICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYS 86
Query: 106 GASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYI 165
A LHLG+N +Q+I TGAF GL+ L+RLHLNNNKLE+LR+DTFLGLE+LEYLQ DYNYI
Sbjct: 87 NAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYI 146
Query: 166 SVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMD 225
S IE AF KL+ L+VLILNDNLL SLP+N+FRFV LTHLDLRGNRLK++P+ G+L+H+
Sbjct: 147 SAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMPFAGVLEHIG 206
Query: 226 KVVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCP 285
++E+QLEENPWNC+C+L+ LK WLD+I+ VG++VCETPFRLHG+D+ ++++Q+LCP
Sbjct: 207 GIMEIQLEENPWNCTCDLLPLKAWLDTIT--VFVGEIVCETPFRLHGKDVTQLTRQDLCP 264
Query: 286 RRLISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPT 345
R+ SD R H T + A+ P + PK +R P K R RPT
Sbjct: 265 RKSASDSSQRGS---------HADTHVQRLSPTMNPALN--PTRAPKASRPP-KMRNRPT 312
Query: 346 SRQP-SKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAEL 404
R SKD ++GP + YQTKSPVPL CP++C C Q SD GLNVNCQERK +I++L
Sbjct: 313 PRVTVSKDR--QSFGPIMVYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDL 370
Query: 405 QPKPYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYL 464
QPKP +PKK+YLT NY+ V + D LE + LDLLHLGNNRI++IQ+ AF +LT+LRRLYL
Sbjct: 371 QPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYL 430
Query: 465 NGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGV 524
NGN +E L P +F GLQSLQYL+L+YN+I+EI+ TFD + NLQLLFLNNNLL+++P +
Sbjct: 431 NGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNI 490
Query: 525 FSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVG 584
F G L RLNLR+NHF+ LPV GVLDQL + IQIDL +NPWDCTCDI+G+K W E
Sbjct: 491 FGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSP 550
Query: 585 VLVDEVICKAPKKFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLN 644
V+++EV C++P K A ++ + E +CPD ++ T + +
Sbjct: 551 VIINEVTCESPAKHAGEILKFLGREAICPDSPNLSDGTVLSMN----------------H 594
Query: 645 STGAPASLGAGGGA-----SSVPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDH 699
+T P SL + + VPLSVLIL LL+VFI+SV AGLFV V+KRRK S
Sbjct: 595 NTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPSVP 654
Query: 700 TSTNNSDVSSFNMQYSVYGGGGGTGGHPHAHVHHRGPALPKVKTPAGHVYEYIPHPLGHM 759
+TNN DVSSF +QY Y + H + GHVY YIP P+G M
Sbjct: 655 RNTNNLDVSSFQLQYGSY----------NTETHDK---------TDGHVYNYIPPPVGQM 695
Query: 760 CKNPIYRSREGNSVEDYKDLHELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGE 819
C+NPIY +EG+ V Y++L E S +L+++++ P
Sbjct: 696 CQNPIYMQKEGDPVAYYRNLQEF-----SYSNLEEKKEEP-------------------- 730
Query: 820 EERRESHHLRSPAYSVSTIEPREDLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPK 879
+PAY++S E E +P ++ + Y+ I E K + L Y
Sbjct: 731 ---------ATPAYTISATELLEKQATP-REPELLYQNIAERVKELPSA----GLVHYNF 776
Query: 880 FPCSPAAYTFSPNYDLRRPHQYLHPGAGDSRLREPVLYSPPSAVFVEPNRNEYLELKAKL 939
C+ F+P+Y+ RR +Q R+ + VLY P FV ++ + L+AK
Sbjct: 777 --CTLPKRQFAPSYESRRQNQ--------DRINKTVLYGTPRKCFVGQSKPNHPLLQAKP 826
Query: 940 NVEPDYLEVLEKQTTFSQ 957
EPDYLEVLEKQT SQ
Sbjct: 827 QSEPDYLEVLEKQTAISQ 844
>gi|221136977 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 799 bits (2063), Expect = 0.0
Identities = 440/918 (47%), Positives = 584/918 (63%), Gaps = 106/918 (11%)
Query: 46 EICDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYT 105
+IC C CEEK+ +L ++CEN+G ++S + PP++ IY L L+GNLL RLYPNEFVNY+
Sbjct: 27 DICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYS 86
Query: 106 GASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYI 165
A LHLG+N +Q+I TGAF GL+ L+RLHLNNNKLE+LR+DTFLGLE+LEYLQ DYNYI
Sbjct: 87 NAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYI 146
Query: 166 SVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMD 225
S IE AF KL+ L+VLILNDNLL SLP+N+FRFV LTHLDLRGNRLK++P+ G+L+H+
Sbjct: 147 SAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMPFAGVLEHIG 206
Query: 226 KVVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCP 285
++E+QLEENPWNC+C+L+ LK WLD+I+ VG++VCETPFRLHG+D+ ++++Q+LCP
Sbjct: 207 GIMEIQLEENPWNCTCDLLPLKAWLDTIT--VFVGEIVCETPFRLHGKDVTQLTRQDLCP 264
Query: 286 RRLISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPT 345
R+ SD R H T + A+ P + PK +R P K R RPT
Sbjct: 265 RKSASDSSQRGS---------HADTHVQRLSPTMNPALN--PTRAPKASRPP-KMRNRPT 312
Query: 346 SRQP-SKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAEL 404
R SKD ++GP + YQTKSPVPL CP++C C Q SD GLNVNCQERK +I++L
Sbjct: 313 PRVTVSKDR--QSFGPIMVYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDL 370
Query: 405 QPKPYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYL 464
QPKP +PKK+YLT NY+ V + D LE + LDLLHLGNNRI++IQ+ AF +LT+LRRLYL
Sbjct: 371 QPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYL 430
Query: 465 NGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGV 524
NGN +E L P +F GLQSLQYL+L+YN+I+EI+ TFD + NLQLLFLNNNLL+++P +
Sbjct: 431 NGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNI 490
Query: 525 FSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVG 584
F G L RLNLR+NHF+ LPV GVLDQL + IQIDL +NPWDCTCDI+G+K W E
Sbjct: 491 FGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSP 550
Query: 585 VLVDEVICKAPKKFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLN 644
V+++EV C++P K A ++ + E +CPD ++ T + +
Sbjct: 551 VIINEVTCESPAKHAGEILKFLGREAICPDSPNLSDGTVLSMN----------------H 594
Query: 645 STGAPASLGAGGGA-----SSVPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDH 699
+T P SL + + VPLSVLIL LL+VFI+SV AGLFV V+KRRK S
Sbjct: 595 NTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPSVP 654
Query: 700 TSTNNSDVSSFNMQYSVYGGGGGTGGHPHAHVHHRGPALPKVKTPAGHVYEYIPHPLGHM 759
+TNN DVSSF +QY Y + H + GHVY YIP P+G M
Sbjct: 655 RNTNNLDVSSFQLQYGSY----------NTETHDK---------TDGHVYNYIPPPVGQM 695
Query: 760 CKNPIYRSREGNSVEDYKDLHELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGE 819
C+NPIY +EG+ V Y++L E S +L+++++ P
Sbjct: 696 CQNPIYMQKEGDPVAYYRNLQEF-----SYSNLEEKKEEP-------------------- 730
Query: 820 EERRESHHLRSPAYSVSTIEPREDLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPK 879
+PAY++S E E +P ++ + Y+ I E K + L Y
Sbjct: 731 ---------ATPAYTISATELLEKQATP-REPELLYQNIAERVKELPSA----GLVHYNF 776
Query: 880 FPCSPAAYTFSPNYDLRRPHQYLHPGAGDSRLREPVLYSPPSAVFVEPNRNEYLELKAKL 939
C+ F+P+Y+ RR +Q R+ + VLY P FV ++ + L+AK
Sbjct: 777 --CTLPKRQFAPSYESRRQNQ--------DRINKTVLYGTPRKCFVGQSKPNHPLLQAKP 826
Query: 940 NVEPDYLEVLEKQTTFSQ 957
EPDYLEVLEKQT SQ
Sbjct: 827 QSEPDYLEVLEKQTAISQ 844
>gi|221136973 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 799 bits (2063), Expect = 0.0
Identities = 440/918 (47%), Positives = 584/918 (63%), Gaps = 106/918 (11%)
Query: 46 EICDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYT 105
+IC C CEEK+ +L ++CEN+G ++S + PP++ IY L L+GNLL RLYPNEFVNY+
Sbjct: 27 DICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYS 86
Query: 106 GASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYI 165
A LHLG+N +Q+I TGAF GL+ L+RLHLNNNKLE+LR+DTFLGLE+LEYLQ DYNYI
Sbjct: 87 NAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYI 146
Query: 166 SVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMD 225
S IE AF KL+ L+VLILNDNLL SLP+N+FRFV LTHLDLRGNRLK++P+ G+L+H+
Sbjct: 147 SAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMPFAGVLEHIG 206
Query: 226 KVVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCP 285
++E+QLEENPWNC+C+L+ LK WLD+I+ VG++VCETPFRLHG+D+ ++++Q+LCP
Sbjct: 207 GIMEIQLEENPWNCTCDLLPLKAWLDTIT--VFVGEIVCETPFRLHGKDVTQLTRQDLCP 264
Query: 286 RRLISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPT 345
R+ SD R H T + A+ P + PK +R P K R RPT
Sbjct: 265 RKSASDSSQRGS---------HADTHVQRLSPTMNPALN--PTRAPKASRPP-KMRNRPT 312
Query: 346 SRQP-SKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAEL 404
R SKD ++GP + YQTKSPVPL CP++C C Q SD GLNVNCQERK +I++L
Sbjct: 313 PRVTVSKDR--QSFGPIMVYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDL 370
Query: 405 QPKPYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYL 464
QPKP +PKK+YLT NY+ V + D LE + LDLLHLGNNRI++IQ+ AF +LT+LRRLYL
Sbjct: 371 QPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYL 430
Query: 465 NGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGV 524
NGN +E L P +F GLQSLQYL+L+YN+I+EI+ TFD + NLQLLFLNNNLL+++P +
Sbjct: 431 NGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNI 490
Query: 525 FSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVG 584
F G L RLNLR+NHF+ LPV GVLDQL + IQIDL +NPWDCTCDI+G+K W E
Sbjct: 491 FGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSP 550
Query: 585 VLVDEVICKAPKKFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLN 644
V+++EV C++P K A ++ + E +CPD ++ T + +
Sbjct: 551 VIINEVTCESPAKHAGEILKFLGREAICPDSPNLSDGTVLSMN----------------H 594
Query: 645 STGAPASLGAGGGA-----SSVPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDH 699
+T P SL + + VPLSVLIL LL+VFI+SV AGLFV V+KRRK S
Sbjct: 595 NTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPSVP 654
Query: 700 TSTNNSDVSSFNMQYSVYGGGGGTGGHPHAHVHHRGPALPKVKTPAGHVYEYIPHPLGHM 759
+TNN DVSSF +QY Y + H + GHVY YIP P+G M
Sbjct: 655 RNTNNLDVSSFQLQYGSY----------NTETHDK---------TDGHVYNYIPPPVGQM 695
Query: 760 CKNPIYRSREGNSVEDYKDLHELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGE 819
C+NPIY +EG+ V Y++L E S +L+++++ P
Sbjct: 696 CQNPIYMQKEGDPVAYYRNLQEF-----SYSNLEEKKEEP-------------------- 730
Query: 820 EERRESHHLRSPAYSVSTIEPREDLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPK 879
+PAY++S E E +P ++ + Y+ I E K + L Y
Sbjct: 731 ---------ATPAYTISATELLEKQATP-REPELLYQNIAERVKELPSA----GLVHYNF 776
Query: 880 FPCSPAAYTFSPNYDLRRPHQYLHPGAGDSRLREPVLYSPPSAVFVEPNRNEYLELKAKL 939
C+ F+P+Y+ RR +Q R+ + VLY P FV ++ + L+AK
Sbjct: 777 --CTLPKRQFAPSYESRRQNQ--------DRINKTVLYGTPRKCFVGQSKPNHPLLQAKP 826
Query: 940 NVEPDYLEVLEKQTTFSQ 957
EPDYLEVLEKQT SQ
Sbjct: 827 QSEPDYLEVLEKQTAISQ 844
>gi|221136969 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 799 bits (2063), Expect = 0.0
Identities = 440/918 (47%), Positives = 584/918 (63%), Gaps = 106/918 (11%)
Query: 46 EICDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYT 105
+IC C CEEK+ +L ++CEN+G ++S + PP++ IY L L+GNLL RLYPNEFVNY+
Sbjct: 27 DICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYS 86
Query: 106 GASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYI 165
A LHLG+N +Q+I TGAF GL+ L+RLHLNNNKLE+LR+DTFLGLE+LEYLQ DYNYI
Sbjct: 87 NAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYI 146
Query: 166 SVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMD 225
S IE AF KL+ L+VLILNDNLL SLP+N+FRFV LTHLDLRGNRLK++P+ G+L+H+
Sbjct: 147 SAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMPFAGVLEHIG 206
Query: 226 KVVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCP 285
++E+QLEENPWNC+C+L+ LK WLD+I+ VG++VCETPFRLHG+D+ ++++Q+LCP
Sbjct: 207 GIMEIQLEENPWNCTCDLLPLKAWLDTIT--VFVGEIVCETPFRLHGKDVTQLTRQDLCP 264
Query: 286 RRLISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPT 345
R+ SD R H T + A+ P + PK +R P K R RPT
Sbjct: 265 RKSASDSSQRGS---------HADTHVQRLSPTMNPALN--PTRAPKASRPP-KMRNRPT 312
Query: 346 SRQP-SKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAEL 404
R SKD ++GP + YQTKSPVPL CP++C C Q SD GLNVNCQERK +I++L
Sbjct: 313 PRVTVSKDR--QSFGPIMVYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDL 370
Query: 405 QPKPYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYL 464
QPKP +PKK+YLT NY+ V + D LE + LDLLHLGNNRI++IQ+ AF +LT+LRRLYL
Sbjct: 371 QPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYL 430
Query: 465 NGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGV 524
NGN +E L P +F GLQSLQYL+L+YN+I+EI+ TFD + NLQLLFLNNNLL+++P +
Sbjct: 431 NGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNI 490
Query: 525 FSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVG 584
F G L RLNLR+NHF+ LPV GVLDQL + IQIDL +NPWDCTCDI+G+K W E
Sbjct: 491 FGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSP 550
Query: 585 VLVDEVICKAPKKFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLN 644
V+++EV C++P K A ++ + E +CPD ++ T + +
Sbjct: 551 VIINEVTCESPAKHAGEILKFLGREAICPDSPNLSDGTVLSMN----------------H 594
Query: 645 STGAPASLGAGGGA-----SSVPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDH 699
+T P SL + + VPLSVLIL LL+VFI+SV AGLFV V+KRRK S
Sbjct: 595 NTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPSVP 654
Query: 700 TSTNNSDVSSFNMQYSVYGGGGGTGGHPHAHVHHRGPALPKVKTPAGHVYEYIPHPLGHM 759
+TNN DVSSF +QY Y + H + GHVY YIP P+G M
Sbjct: 655 RNTNNLDVSSFQLQYGSY----------NTETHDK---------TDGHVYNYIPPPVGQM 695
Query: 760 CKNPIYRSREGNSVEDYKDLHELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGE 819
C+NPIY +EG+ V Y++L E S +L+++++ P
Sbjct: 696 CQNPIYMQKEGDPVAYYRNLQEF-----SYSNLEEKKEEP-------------------- 730
Query: 820 EERRESHHLRSPAYSVSTIEPREDLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPK 879
+PAY++S E E +P ++ + Y+ I E K + L Y
Sbjct: 731 ---------ATPAYTISATELLEKQATP-REPELLYQNIAERVKELPSA----GLVHYNF 776
Query: 880 FPCSPAAYTFSPNYDLRRPHQYLHPGAGDSRLREPVLYSPPSAVFVEPNRNEYLELKAKL 939
C+ F+P+Y+ RR +Q R+ + VLY P FV ++ + L+AK
Sbjct: 777 --CTLPKRQFAPSYESRRQNQ--------DRINKTVLYGTPRKCFVGQSKPNHPLLQAKP 826
Query: 940 NVEPDYLEVLEKQTTFSQ 957
EPDYLEVLEKQT SQ
Sbjct: 827 QSEPDYLEVLEKQTAISQ 844
>gi|221136965 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 799 bits (2063), Expect = 0.0
Identities = 440/918 (47%), Positives = 584/918 (63%), Gaps = 106/918 (11%)
Query: 46 EICDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYT 105
+IC C CEEK+ +L ++CEN+G ++S + PP++ IY L L+GNLL RLYPNEFVNY+
Sbjct: 27 DICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYS 86
Query: 106 GASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYI 165
A LHLG+N +Q+I TGAF GL+ L+RLHLNNNKLE+LR+DTFLGLE+LEYLQ DYNYI
Sbjct: 87 NAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYI 146
Query: 166 SVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMD 225
S IE AF KL+ L+VLILNDNLL SLP+N+FRFV LTHLDLRGNRLK++P+ G+L+H+
Sbjct: 147 SAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMPFAGVLEHIG 206
Query: 226 KVVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCP 285
++E+QLEENPWNC+C+L+ LK WLD+I+ VG++VCETPFRLHG+D+ ++++Q+LCP
Sbjct: 207 GIMEIQLEENPWNCTCDLLPLKAWLDTIT--VFVGEIVCETPFRLHGKDVTQLTRQDLCP 264
Query: 286 RRLISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPT 345
R+ SD R H T + A+ P + PK +R P K R RPT
Sbjct: 265 RKSASDSSQRGS---------HADTHVQRLSPTMNPALN--PTRAPKASRPP-KMRNRPT 312
Query: 346 SRQP-SKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAEL 404
R SKD ++GP + YQTKSPVPL CP++C C Q SD GLNVNCQERK +I++L
Sbjct: 313 PRVTVSKDR--QSFGPIMVYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDL 370
Query: 405 QPKPYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYL 464
QPKP +PKK+YLT NY+ V + D LE + LDLLHLGNNRI++IQ+ AF +LT+LRRLYL
Sbjct: 371 QPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYL 430
Query: 465 NGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGV 524
NGN +E L P +F GLQSLQYL+L+YN+I+EI+ TFD + NLQLLFLNNNLL+++P +
Sbjct: 431 NGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNI 490
Query: 525 FSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVG 584
F G L RLNLR+NHF+ LPV GVLDQL + IQIDL +NPWDCTCDI+G+K W E
Sbjct: 491 FGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSP 550
Query: 585 VLVDEVICKAPKKFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLN 644
V+++EV C++P K A ++ + E +CPD ++ T + +
Sbjct: 551 VIINEVTCESPAKHAGEILKFLGREAICPDSPNLSDGTVLSMN----------------H 594
Query: 645 STGAPASLGAGGGA-----SSVPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDH 699
+T P SL + + VPLSVLIL LL+VFI+SV AGLFV V+KRRK S
Sbjct: 595 NTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPSVP 654
Query: 700 TSTNNSDVSSFNMQYSVYGGGGGTGGHPHAHVHHRGPALPKVKTPAGHVYEYIPHPLGHM 759
+TNN DVSSF +QY Y + H + GHVY YIP P+G M
Sbjct: 655 RNTNNLDVSSFQLQYGSY----------NTETHDK---------TDGHVYNYIPPPVGQM 695
Query: 760 CKNPIYRSREGNSVEDYKDLHELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGE 819
C+NPIY +EG+ V Y++L E S +L+++++ P
Sbjct: 696 CQNPIYMQKEGDPVAYYRNLQEF-----SYSNLEEKKEEP-------------------- 730
Query: 820 EERRESHHLRSPAYSVSTIEPREDLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPK 879
+PAY++S E E +P ++ + Y+ I E K + L Y
Sbjct: 731 ---------ATPAYTISATELLEKQATP-REPELLYQNIAERVKELPSA----GLVHYNF 776
Query: 880 FPCSPAAYTFSPNYDLRRPHQYLHPGAGDSRLREPVLYSPPSAVFVEPNRNEYLELKAKL 939
C+ F+P+Y+ RR +Q R+ + VLY P FV ++ + L+AK
Sbjct: 777 --CTLPKRQFAPSYESRRQNQ--------DRINKTVLYGTPRKCFVGQSKPNHPLLQAKP 826
Query: 940 NVEPDYLEVLEKQTTFSQ 957
EPDYLEVLEKQT SQ
Sbjct: 827 QSEPDYLEVLEKQTAISQ 844
>gi|221136961 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 799 bits (2063), Expect = 0.0
Identities = 440/918 (47%), Positives = 584/918 (63%), Gaps = 106/918 (11%)
Query: 46 EICDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYT 105
+IC C CEEK+ +L ++CEN+G ++S + PP++ IY L L+GNLL RLYPNEFVNY+
Sbjct: 27 DICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYS 86
Query: 106 GASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYI 165
A LHLG+N +Q+I TGAF GL+ L+RLHLNNNKLE+LR+DTFLGLE+LEYLQ DYNYI
Sbjct: 87 NAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYI 146
Query: 166 SVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMD 225
S IE AF KL+ L+VLILNDNLL SLP+N+FRFV LTHLDLRGNRLK++P+ G+L+H+
Sbjct: 147 SAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMPFAGVLEHIG 206
Query: 226 KVVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCP 285
++E+QLEENPWNC+C+L+ LK WLD+I+ VG++VCETPFRLHG+D+ ++++Q+LCP
Sbjct: 207 GIMEIQLEENPWNCTCDLLPLKAWLDTIT--VFVGEIVCETPFRLHGKDVTQLTRQDLCP 264
Query: 286 RRLISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPT 345
R+ SD R H T + A+ P + PK +R P K R RPT
Sbjct: 265 RKSASDSSQRGS---------HADTHVQRLSPTMNPALN--PTRAPKASRPP-KMRNRPT 312
Query: 346 SRQP-SKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAEL 404
R SKD ++GP + YQTKSPVPL CP++C C Q SD GLNVNCQERK +I++L
Sbjct: 313 PRVTVSKDR--QSFGPIMVYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDL 370
Query: 405 QPKPYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYL 464
QPKP +PKK+YLT NY+ V + D LE + LDLLHLGNNRI++IQ+ AF +LT+LRRLYL
Sbjct: 371 QPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYL 430
Query: 465 NGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGV 524
NGN +E L P +F GLQSLQYL+L+YN+I+EI+ TFD + NLQLLFLNNNLL+++P +
Sbjct: 431 NGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNI 490
Query: 525 FSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVG 584
F G L RLNLR+NHF+ LPV GVLDQL + IQIDL +NPWDCTCDI+G+K W E
Sbjct: 491 FGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSP 550
Query: 585 VLVDEVICKAPKKFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLN 644
V+++EV C++P K A ++ + E +CPD ++ T + +
Sbjct: 551 VIINEVTCESPAKHAGEILKFLGREAICPDSPNLSDGTVLSMN----------------H 594
Query: 645 STGAPASLGAGGGA-----SSVPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDH 699
+T P SL + + VPLSVLIL LL+VFI+SV AGLFV V+KRRK S
Sbjct: 595 NTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPSVP 654
Query: 700 TSTNNSDVSSFNMQYSVYGGGGGTGGHPHAHVHHRGPALPKVKTPAGHVYEYIPHPLGHM 759
+TNN DVSSF +QY Y + H + GHVY YIP P+G M
Sbjct: 655 RNTNNLDVSSFQLQYGSY----------NTETHDK---------TDGHVYNYIPPPVGQM 695
Query: 760 CKNPIYRSREGNSVEDYKDLHELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGE 819
C+NPIY +EG+ V Y++L E S +L+++++ P
Sbjct: 696 CQNPIYMQKEGDPVAYYRNLQEF-----SYSNLEEKKEEP-------------------- 730
Query: 820 EERRESHHLRSPAYSVSTIEPREDLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPK 879
+PAY++S E E +P ++ + Y+ I E K + L Y
Sbjct: 731 ---------ATPAYTISATELLEKQATP-REPELLYQNIAERVKELPSA----GLVHYNF 776
Query: 880 FPCSPAAYTFSPNYDLRRPHQYLHPGAGDSRLREPVLYSPPSAVFVEPNRNEYLELKAKL 939
C+ F+P+Y+ RR +Q R+ + VLY P FV ++ + L+AK
Sbjct: 777 --CTLPKRQFAPSYESRRQNQ--------DRINKTVLYGTPRKCFVGQSKPNHPLLQAKP 826
Query: 940 NVEPDYLEVLEKQTTFSQ 957
EPDYLEVLEKQT SQ
Sbjct: 827 QSEPDYLEVLEKQTAISQ 844
>gi|221136957 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 799 bits (2063), Expect = 0.0
Identities = 440/918 (47%), Positives = 584/918 (63%), Gaps = 106/918 (11%)
Query: 46 EICDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYT 105
+IC C CEEK+ +L ++CEN+G ++S + PP++ IY L L+GNLL RLYPNEFVNY+
Sbjct: 27 DICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYS 86
Query: 106 GASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYI 165
A LHLG+N +Q+I TGAF GL+ L+RLHLNNNKLE+LR+DTFLGLE+LEYLQ DYNYI
Sbjct: 87 NAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYI 146
Query: 166 SVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMD 225
S IE AF KL+ L+VLILNDNLL SLP+N+FRFV LTHLDLRGNRLK++P+ G+L+H+
Sbjct: 147 SAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMPFAGVLEHIG 206
Query: 226 KVVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCP 285
++E+QLEENPWNC+C+L+ LK WLD+I+ VG++VCETPFRLHG+D+ ++++Q+LCP
Sbjct: 207 GIMEIQLEENPWNCTCDLLPLKAWLDTIT--VFVGEIVCETPFRLHGKDVTQLTRQDLCP 264
Query: 286 RRLISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPT 345
R+ SD R H T + A+ P + PK +R P K R RPT
Sbjct: 265 RKSASDSSQRGS---------HADTHVQRLSPTMNPALN--PTRAPKASRPP-KMRNRPT 312
Query: 346 SRQP-SKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAEL 404
R SKD ++GP + YQTKSPVPL CP++C C Q SD GLNVNCQERK +I++L
Sbjct: 313 PRVTVSKDR--QSFGPIMVYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDL 370
Query: 405 QPKPYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYL 464
QPKP +PKK+YLT NY+ V + D LE + LDLLHLGNNRI++IQ+ AF +LT+LRRLYL
Sbjct: 371 QPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYL 430
Query: 465 NGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGV 524
NGN +E L P +F GLQSLQYL+L+YN+I+EI+ TFD + NLQLLFLNNNLL+++P +
Sbjct: 431 NGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNI 490
Query: 525 FSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVG 584
F G L RLNLR+NHF+ LPV GVLDQL + IQIDL +NPWDCTCDI+G+K W E
Sbjct: 491 FGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSP 550
Query: 585 VLVDEVICKAPKKFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLN 644
V+++EV C++P K A ++ + E +CPD ++ T + +
Sbjct: 551 VIINEVTCESPAKHAGEILKFLGREAICPDSPNLSDGTVLSMN----------------H 594
Query: 645 STGAPASLGAGGGA-----SSVPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDH 699
+T P SL + + VPLSVLIL LL+VFI+SV AGLFV V+KRRK S
Sbjct: 595 NTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPSVP 654
Query: 700 TSTNNSDVSSFNMQYSVYGGGGGTGGHPHAHVHHRGPALPKVKTPAGHVYEYIPHPLGHM 759
+TNN DVSSF +QY Y + H + GHVY YIP P+G M
Sbjct: 655 RNTNNLDVSSFQLQYGSY----------NTETHDK---------TDGHVYNYIPPPVGQM 695
Query: 760 CKNPIYRSREGNSVEDYKDLHELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGE 819
C+NPIY +EG+ V Y++L E S +L+++++ P
Sbjct: 696 CQNPIYMQKEGDPVAYYRNLQEF-----SYSNLEEKKEEP-------------------- 730
Query: 820 EERRESHHLRSPAYSVSTIEPREDLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPK 879
+PAY++S E E +P ++ + Y+ I E K + L Y
Sbjct: 731 ---------ATPAYTISATELLEKQATP-REPELLYQNIAERVKELPSA----GLVHYNF 776
Query: 880 FPCSPAAYTFSPNYDLRRPHQYLHPGAGDSRLREPVLYSPPSAVFVEPNRNEYLELKAKL 939
C+ F+P+Y+ RR +Q R+ + VLY P FV ++ + L+AK
Sbjct: 777 --CTLPKRQFAPSYESRRQNQ--------DRINKTVLYGTPRKCFVGQSKPNHPLLQAKP 826
Query: 940 NVEPDYLEVLEKQTTFSQ 957
EPDYLEVLEKQT SQ
Sbjct: 827 QSEPDYLEVLEKQTAISQ 844
>gi|33504581 SLIT and NTRK-like family, member 2 [Homo sapiens]
Length = 845
Score = 799 bits (2063), Expect = 0.0
Identities = 440/918 (47%), Positives = 584/918 (63%), Gaps = 106/918 (11%)
Query: 46 EICDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYT 105
+IC C CEEK+ +L ++CEN+G ++S + PP++ IY L L+GNLL RLYPNEFVNY+
Sbjct: 27 DICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYS 86
Query: 106 GASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYI 165
A LHLG+N +Q+I TGAF GL+ L+RLHLNNNKLE+LR+DTFLGLE+LEYLQ DYNYI
Sbjct: 87 NAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYI 146
Query: 166 SVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMD 225
S IE AF KL+ L+VLILNDNLL SLP+N+FRFV LTHLDLRGNRLK++P+ G+L+H+
Sbjct: 147 SAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMPFAGVLEHIG 206
Query: 226 KVVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCP 285
++E+QLEENPWNC+C+L+ LK WLD+I+ VG++VCETPFRLHG+D+ ++++Q+LCP
Sbjct: 207 GIMEIQLEENPWNCTCDLLPLKAWLDTIT--VFVGEIVCETPFRLHGKDVTQLTRQDLCP 264
Query: 286 RRLISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPT 345
R+ SD R H T + A+ P + PK +R P K R RPT
Sbjct: 265 RKSASDSSQRGS---------HADTHVQRLSPTMNPALN--PTRAPKASRPP-KMRNRPT 312
Query: 346 SRQP-SKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAEL 404
R SKD ++GP + YQTKSPVPL CP++C C Q SD GLNVNCQERK +I++L
Sbjct: 313 PRVTVSKDR--QSFGPIMVYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDL 370
Query: 405 QPKPYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYL 464
QPKP +PKK+YLT NY+ V + D LE + LDLLHLGNNRI++IQ+ AF +LT+LRRLYL
Sbjct: 371 QPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYL 430
Query: 465 NGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGV 524
NGN +E L P +F GLQSLQYL+L+YN+I+EI+ TFD + NLQLLFLNNNLL+++P +
Sbjct: 431 NGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNI 490
Query: 525 FSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVG 584
F G L RLNLR+NHF+ LPV GVLDQL + IQIDL +NPWDCTCDI+G+K W E
Sbjct: 491 FGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSP 550
Query: 585 VLVDEVICKAPKKFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLN 644
V+++EV C++P K A ++ + E +CPD ++ T + +
Sbjct: 551 VIINEVTCESPAKHAGEILKFLGREAICPDSPNLSDGTVLSMN----------------H 594
Query: 645 STGAPASLGAGGGA-----SSVPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDH 699
+T P SL + + VPLSVLIL LL+VFI+SV AGLFV V+KRRK S
Sbjct: 595 NTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPSVP 654
Query: 700 TSTNNSDVSSFNMQYSVYGGGGGTGGHPHAHVHHRGPALPKVKTPAGHVYEYIPHPLGHM 759
+TNN DVSSF +QY Y + H + GHVY YIP P+G M
Sbjct: 655 RNTNNLDVSSFQLQYGSY----------NTETHDK---------TDGHVYNYIPPPVGQM 695
Query: 760 CKNPIYRSREGNSVEDYKDLHELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGE 819
C+NPIY +EG+ V Y++L E S +L+++++ P
Sbjct: 696 CQNPIYMQKEGDPVAYYRNLQEF-----SYSNLEEKKEEP-------------------- 730
Query: 820 EERRESHHLRSPAYSVSTIEPREDLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPK 879
+PAY++S E E +P ++ + Y+ I E K + L Y
Sbjct: 731 ---------ATPAYTISATELLEKQATP-REPELLYQNIAERVKELPSA----GLVHYNF 776
Query: 880 FPCSPAAYTFSPNYDLRRPHQYLHPGAGDSRLREPVLYSPPSAVFVEPNRNEYLELKAKL 939
C+ F+P+Y+ RR +Q R+ + VLY P FV ++ + L+AK
Sbjct: 777 --CTLPKRQFAPSYESRRQNQ--------DRINKTVLYGTPRKCFVGQSKPNHPLLQAKP 826
Query: 940 NVEPDYLEVLEKQTTFSQ 957
EPDYLEVLEKQT SQ
Sbjct: 827 QSEPDYLEVLEKQTAISQ 844
>gi|40217820 slit and trk like 3 protein [Homo sapiens]
Length = 977
Score = 694 bits (1791), Expect = 0.0
Identities = 417/1012 (41%), Positives = 582/1012 (57%), Gaps = 108/1012 (10%)
Query: 9 TLEQDLHRKMHSW--MLQTLAFAVTSLV--LSCAETIDYYGEICDNACPCEEKDGILTVS 64
++ + LHR W +L T+A T+ + + +E ID E C + C CE K+ + +
Sbjct: 4 SIAEMLHRGRMLWIILLSTIALGWTTPIPLIEDSEEID---EPCFDPCYCEVKESLFHIH 60
Query: 65 CENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGA 124
C+++G ++S+I+ + L L N + +LY N F++ A ++LG+N +QDI+TGA
Sbjct: 61 CDSKGFTNISQITEFWSRPFKLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGA 120
Query: 125 FHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLIL 184
F+GL+ L+RL+L+ NKL++ R+DTFLGLE+LEYLQ DYN I IE AF L L+VLIL
Sbjct: 121 FNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLIL 180
Query: 185 NDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMDK-VVELQLEENPWNCSCEL 243
NDNL+ LP NLF+ V LTHLDLRGNRLK+L Y G+L H+ + ++ELQLEENPWNC+CE+
Sbjct: 181 NDNLIPMLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEI 240
Query: 244 ISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPRRLISDYEMR-----PQT 298
+ LK WL+ I Y+ALVGD+ CETPF HG+DL E+ K ELCP L+SD E+ P +
Sbjct: 241 VQLKSWLERIPYTALVGDITCETPFHFHGKDLREIRKTELCP--LLSDSEVEASLGIPHS 298
Query: 299 PLSTTGYLHTTPASVNSVA--TSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQPSKDLGYS 356
S T P+S+ S T+SS YK K PK T+QP PR TS+
Sbjct: 299 SSSKENAWPTKPSSMLSSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPG---P 355
Query: 357 NYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYL 416
N P YQT+ P+P+ CPT C+CNL I+DLGL VNC+ER +I+EL P+P N KK+YL
Sbjct: 356 NQPPIAPYQTRPPIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYL 415
Query: 417 TENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPEL 476
+ N I + R+DF + LDLLHLGNNRIS +QD AF +L NL+ L+LNGN IE+L+P +
Sbjct: 416 SSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGM 475
Query: 477 FYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLRLNLR 536
F GLQSL YL+ ++N+IREIQ F +PNL+LLFLNNNLL+ +P+ F+G +L RLNLR
Sbjct: 476 FRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLR 535
Query: 537 SNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPK 596
N+F LPV+GVL+ L +++QIDL++NPWDCTCD+V K W+E + +V +V+C++P+
Sbjct: 536 KNYFLYLPVAGVLEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPE 595
Query: 597 KFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLNSTGAPASLGAGG 656
D+R+I+ E+LCP+ V + +P+ A T A +P G
Sbjct: 596 NLTHRDVRTIELEVLCPEMLHVAPAGESPAQPGDSHLIGAPTSA-------SPYEFSPPG 648
Query: 657 GASSVPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDHTSTNNS-DVSSFNMQ-Y 714
G VPLSVLILSLL++F +VFVAAGLF V++RR+K + D++ MQ +
Sbjct: 649 GP--VPLSVLILSLLVLFFSAVFVAAGLFAYVLRRRRKKLPFRSKRQEGVDLTGIQMQCH 706
Query: 715 SVY----GGGGGTGGHPHAHVHHRGPALPKVKTPAGHVYEYIPHPLGHMCKNPIYRSREG 770
++ GGGGG+GG + + P+ P GHVYEYIPHP+ MC NPIY
Sbjct: 707 RLFEDGGGGGGGSGGGGRPTL-----SSPEKAPPVGHVYEYIPHPVTQMCNNPIY----- 756
Query: 771 NSVEDYKDLHELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGEEERRESHHLRS 830
K E +V SS Q+ P QPP + G E+ E+
Sbjct: 757 ------KPREEEEVAVSS-----AQEAGSAERGGPGTQPPGMGEALLGSEQFAETPKENH 805
Query: 831 PAYSVSTIEPREDLLSPVQDADRFYRGILEPDKHCSTTPA-----------GNSLPEYPK 879
Y + +E ++ V + I+ + H PA G L +
Sbjct: 806 SNYR-TLLEKEKEWALAVSSSQ--LNTIVTVNHHHPHHPAVGGVSGVVGGTGGDLAGFRH 862
Query: 880 FPCSPAAYTFSPN---------YDLRRPHQ---------------------YLHPGA--- 906
+ F P D RP ++HP
Sbjct: 863 HEKNGGVVLFPPGGGCGSGSMLLDRERPQPAPCTVGFVDCLYGTVPKLKELHVHPPGMQY 922
Query: 907 ----GDSRLREPVLYSPPSAVFV-EPNRNEYLELKAKLNVEPDYLEVLEKQT 953
D+RL+E +L+S + +++YLEL+AKL +PDYLEVLEK T
Sbjct: 923 PDLQQDARLKETLLFSAGKGFTDHQTQKSDYLELRAKLQTKPDYLEVLEKTT 974
>gi|27436867 slit and trk like 4 protein [Homo sapiens]
Length = 837
Score = 680 bits (1755), Expect = 0.0
Identities = 397/941 (42%), Positives = 557/941 (59%), Gaps = 110/941 (11%)
Query: 22 MLQTLAFAVTSLVLSCAETIDYYGEICDNACPCEEKDGILTVSCENRGIISLSEISPPRF 81
M L +++L+ S D EIC N C C + +L V+CE + +++ PP
Sbjct: 1 MFLWLFLILSALISSTNADSDISVEIC-NVCSCVSVENVLYVNCEKVSVYRPNQLKPPWS 59
Query: 82 PIYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKL 141
YHL N LN LYPN F+N++ A LHLG+N +Q+IE GAF GL L++LHLNNN+L
Sbjct: 60 NFYHLNFQNNFLNILYPNTFLNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNEL 119
Query: 142 ELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVP 201
++LR DTFLG+ENLEYLQ DYN I IE AF KLH L+VLILNDNL+S LP+N+FRF
Sbjct: 120 KILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFRFAS 179
Query: 202 LTHLDLRGNRLKLLPYVGLLQHMDKVVELQLEENPWNCSCELISLKDWLDSISYSALVGD 261
LTHLD+RGNR++ LPY+G+L+H+ +VVELQLE+NPWNCSC+L+ LK WL+++ Y+ +G+
Sbjct: 180 LTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGE 239
Query: 262 VVCETPFRLHGRDLDEVSKQELCPRRLISDYEMRPQTPLS-----TTGYLHTTPASVNSV 316
+CETP L+GR L E +KQELCP SD+++R P TT HTT S++ +
Sbjct: 240 AICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTPNGHTTQTSLHRL 299
Query: 317 ATSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQPSKDLGYSNYGPSIAYQTKSPVPLECPT 376
T KPPK T P+K + K L N ++YQT+ P CP
Sbjct: 300 VT----------KPPK-TTNPSKI----SGIVAGKALSNRNLSQIVSYQTRVPPLTPCPA 344
Query: 377 ACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLEATGLD 436
C C SDLGL+VNCQE+ I+S++EL PKP N KK+++ N I V +DF + GLD
Sbjct: 345 PCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLD 404
Query: 437 LLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIREI 496
LLHLG+N+I++I+ F +LTNLRRLYLNGN+IERL PE+F GL +LQYL+L+YNLI+EI
Sbjct: 405 LLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEI 464
Query: 497 QSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLI 556
+GTFD +PNLQLL+LNNNLL+++P +FSG L RLNLR+N F LPVSGVLDQL+SL
Sbjct: 465 SAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLT 524
Query: 557 QIDLHDNPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPKKFAETDMRSIKSELLCPDYS 616
QIDL NPWDCTCD+V +KLWVE+L G++V E+ C+ P +FA +++S+K+E+LCP
Sbjct: 525 QIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCPK-- 582
Query: 617 DVVVSTPTPSSIQVPARTSAVTPAVRLNSTGAPASLGAGGGASSVPLSVLILSLLLVFIM 676
+++ P+ A ++ PA+ + P GG VPLS+LILS+L+V I+
Sbjct: 583 --LLNKPS-------APFTSPAPAITFTTPLGPIRSPPGG---PVPLSILILSILVVLIL 630
Query: 677 SVFVAAGLFVLVMKRRKKNQSDHTSTNNSDVSSFNMQYSVYGGGGGTGGHPHAHVHHRGP 736
+VFVA L V V++R KK H N D S +Q H H ++
Sbjct: 631 TVFVAFCLLVFVLRRNKKPTVKHEGLGNPDCGSMQLQL-----------RKHDHKTNKKD 679
Query: 737 ALPKVKTPAGHVYEYIPHPLGHMCKNPIYRSREGNSVEDYKDLHELKVTYSSNHHLQQQQ 796
L T A +IP + M K+ +E + + D
Sbjct: 680 GL---STEA-----FIPQTIEQMSKSHTCGLKESETGFMFSD------------------ 713
Query: 797 QPPPPPQQPQQQPPPQLQLQPGEEERRESHHLRSPAYSVSTIEPREDLLSPVQDADRFYR 856
PP Q ++ ++ ++ ++ H+ +STI+ ++L P +D++ F +
Sbjct: 714 ---PPGQ--------KVVMRNVADKEKDLLHV-DTRKRLSTIDELDELF-PSRDSNVFIQ 760
Query: 857 GILEPDKHCSTTPAGNSLPEYPKFPCSPAAYTFSPNYDLRRPHQYLHPGAGDSRLREPVL 916
LE K EY S +++R P + D + ++ ++
Sbjct: 761 NFLESKK------------EYNSIGVS--------GFEIRYPEK-----QPDKKSKKSLI 795
Query: 917 YSPPSAVFVEPNRNEYLELKAKLNVEPDYLEVLEKQTTFSQ 957
S + VE ++EY ELKAKL PDYL+VLE+QT ++
Sbjct: 796 GGNHSKIVVEQRKSEYFELKAKLQSSPDYLQVLEEQTALNK 836
>gi|40217825 slit and trk like 6 [Homo sapiens]
Length = 841
Score = 625 bits (1611), Expect = e-179
Identities = 357/915 (39%), Positives = 534/915 (58%), Gaps = 113/915 (12%)
Query: 48 CDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGA 107
CD+ C CEEKDG + ++CE +GI +SEIS P + L L N L L+ N+F T A
Sbjct: 31 CDSLCNCEEKDGTMLINCEAKGIKMVSEISVPPSRPFQLSLLNNGLTMLHTNDFSGLTNA 90
Query: 108 SILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISV 167
+HLG N I DIE GAF+GL L++LH+N+N LE+L++DTF GLENLE+LQ D N+I+V
Sbjct: 91 ISIHLGFNNIADIEIGAFNGLGLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITV 150
Query: 168 IEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMDKV 227
IEP+AF KL+ L+VLILNDN + SLP N+FRFVPLTHLDLRGN+L+ LPYVG L+H+ ++
Sbjct: 151 IEPSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTLPYVGFLEHIGRI 210
Query: 228 VELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPRR 287
++LQLE+N W C+C+L+ LK WL+++ +++GDVVC +P G L + K+ +CP
Sbjct: 211 LDLQLEDNKWACNCDLLQLKTWLENMPPQSIIGDVVCNSPPFFKGSILSRLKKESICPTP 270
Query: 288 LISDYEMRPQTPLSTTGYLH---TTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRP 344
+ + P +G LH T+ + + ++T ++++ K P K P KP
Sbjct: 271 PVYEEHEDP------SGSLHLAATSSINDSRMSTKTTSILKLPTKAPGLIPYITKP---- 320
Query: 345 TSRQPSKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAEL 404
T+ P P CP C+C + +S GL ++CQER IES+++L
Sbjct: 321 --------------------STQLPGPY-CPIPCNCKV-LSPSGLLIHCQERNIESLSDL 358
Query: 405 QPKPYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYL 464
+P P NP+K+ L N I + ++D +E L++LHLGNNRI ++++ +F +LT L++LYL
Sbjct: 359 RPPPQNPRKLILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYL 418
Query: 465 NGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGV 524
NGN + +LS +F GL +L+YL+L+YN I+EI GTF+P+P L++L+LNNNLLQ +P +
Sbjct: 419 NGNHLTKLSKGMFLGLHNLEYLYLEYNAIKEILPGTFNPMPKLKVLYLNNNLLQVLPPHI 478
Query: 525 FSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVG 584
FSG+ L ++NL++N FT LPVS +LD L L QIDL DNPWDC+CD+VG++ W+++L
Sbjct: 479 FSGVPLTKVNLKTNQFTHLPVSNILDDLDLLTQIDLEDNPWDCSCDLVGLQQWIQKLSKN 538
Query: 585 VLVDEVICKAPKKFAETDMRSIKSELLCPDYSDVVVSTPTPSSIQVPARTS---AVTPAV 641
+ D+++C +P + +++++ SE+LCP +V+ P+ +P +TS TPA
Sbjct: 539 TVTDDILCTSPGHLDKKELKALNSEILCPG----LVNNPS-----MPTQTSYLMVTTPAT 589
Query: 642 RLNSTGAPASLGAGGGASSVPLSVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDHTS 701
N+ A +VPLSVLIL LL++FI VF AAG+ VLV+ RR++ +
Sbjct: 590 TTNT----ADTILRSLTDAVPLSVLILGLLIMFITIVFCAAGIVVLVLHRRRRYKKKQVD 645
Query: 702 TNNSDVSSFNMQYSVYGGGGGTGGHPHAHVHHRGPALPKVKTPAGHVYE-YIPHPLGHMC 760
D S ++QYS+YG H HH + P+ +YE ++ P+ H+
Sbjct: 646 EQMRDNSPVHLQYSMYG---------HKTTHHT------TERPSASLYEQHMVSPMVHVY 690
Query: 761 KNPIYRSREGNSVEDYKDLHELKVTYSSNHHLQQQQQPPPPPQQPQQQPPPQLQLQPGEE 820
++P + + HL+++++ + +++ LQ
Sbjct: 691 RSPSFGPK----------------------HLEEEEE------RNEKEGSDAKHLQRSLL 722
Query: 821 ERRESHHLRSPAYSVSTIEPREDLLSPVQDADRFYRGILEPDKHCSTTPAGNSLPEYPKF 880
E+ L T + LS QDA YR ILE ++ + EY +
Sbjct: 723 EQENHSPLTGSNMKYKTTNQSTEFLS-FQDASSLYRNILEKERELQQL----GITEYLR- 776
Query: 881 PCSPAAYTFSPNYDLRRPHQYLH-PGAGDS-RLREPVLYSPPSAVFVEPNRNEYLELKAK 938
N +P H PGA + +L E ++YS P V VE +NEY ELKA
Sbjct: 777 ----------KNIAQLQPDMEAHYPGAHEELKLMETLMYSRPRKVLVEQTKNEYFELKAN 826
Query: 939 LNVEPDYLEVLEKQT 953
L+ EPDYLEVLE+QT
Sbjct: 827 LHAEPDYLEVLEQQT 841
>gi|40217817 slit and trk like 1 protein [Homo sapiens]
Length = 696
Score = 519 bits (1337), Expect = e-147
Identities = 286/698 (40%), Positives = 427/698 (61%), Gaps = 45/698 (6%)
Query: 22 MLQTLAFAVTSLVLSCAETIDYYGEIC-DNACPCEEKDGILTVSCENRGIISLSEISPPR 80
ML + TSL C + G++C + C C E +G L V CE +G SL + P
Sbjct: 1 MLLWILLLETSL---CFAAGNVTGDVCKEKICSCNEIEGDLHVDCEKKGFTSLQRFTAPT 57
Query: 81 FPIYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNK 140
YHL L GN L RL+PNEF N+ A LH+ +N + +I GAF GL+ ++RLH+NNNK
Sbjct: 58 SQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNK 117
Query: 141 LELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFV 200
++ R TFLGL++LEYLQ D+N + I+P AF L+ L+VLILNDNL+S+LP N+F++V
Sbjct: 118 IKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQYV 177
Query: 201 PLTHLDLRGNRLKLLPYVGLLQHMDKVVELQLEENPWNCSCELISLKDWLDSISYSALVG 260
P+THLDLRGNRLK LPY +L+ + + E+ LE+NPW+C+C+L+SLK+WL++I +AL+G
Sbjct: 178 PITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNALIG 237
Query: 261 DVVCETPFRLHGRDLDEVSKQELCPRRLISDYEMRPQTPLSTTGYLH---TTPASVNSVA 317
VVCE P RL G+DL+E ++Q+LCP + D + P P + TP N
Sbjct: 238 RVVCEAPTRLQGKDLNETTEQDLCPLKNRVDSSL-PAPPAQEETFAPGPLPTPFKTNGQE 296
Query: 318 TSSSAVYKPPLKPPKGTRQPN--KPRVRPTSRQPSKDLGYSNYGPSIAYQTKSPVPLECP 375
++ P P GT+ P + ++RPT+ + G S P L CP
Sbjct: 297 DHAT----PGSAPNGGTKIPGNWQIKIRPTAAIAT---GSSRNKPLAN-------SLPCP 342
Query: 376 TACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLEATGL 435
CSC+ I GL +NC R + S+A+L+PK N ++++L +N I +R++ F++ L
Sbjct: 343 GGCSCD-HIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNL 401
Query: 436 DLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIRE 495
LL LGNN I+ +++ F +L +LR LY++ N ++ LS E F GLQ+L+YL ++YN I+
Sbjct: 402 ILLDLGNNNIATVENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQL 461
Query: 496 IQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLRLNLRSNHFTSLPVSGVLDQLKSL 555
I GTF+ +P L++L LNNNLL+++P VF+G++L +L+L +N+F LPV+GVLDQL S+
Sbjct: 462 ILPGTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSI 521
Query: 556 IQIDLHDNPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPKKFAETDMRSIKSELLCPDY 615
IQIDLH NPW+C+C IV K W E+L VL+ ++ C+ P F D + ++ +CP
Sbjct: 522 IQIDLHGNPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNDEICP-- 579
Query: 616 SDVVVSTPTPSSIQVPARTSAVTPAVRLNSTGAPASLGAGGGA----SSVPLSVLILSLL 671
Q+ AR S + NSTG A G + S V +SVL+ LL
Sbjct: 580 -------------QLYARISPTLTSHSKNSTGL-AETGTHSNSYLDTSRVSISVLVPGLL 625
Query: 672 LVFIMSVFVAAGLFVLVMKRRKKNQSDHTSTNNSDVSS 709
LVF+ S F G+ V +++ RK+++ +++ S+++S
Sbjct: 626 LVFVTSAFTVVGMLVFILRNRKRSKRRDANSSASEINS 663
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 117 bits (294), Expect = 4e-26
Identities = 122/539 (22%), Positives = 222/539 (41%), Gaps = 106/539 (19%)
Query: 110 LHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIE 169
+ L N I+ I GAF R LRR+ L+NN++ + D F GL +L L + N I+ +
Sbjct: 314 IRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLP 373
Query: 170 PNAFGKLHLLQVLILNDNLLSSLPNNLFRFVP-LTHLDLRGNRLKLLPYVGLLQHMDKVV 228
FG L+ LQ+L+LN N ++ + + F+ + L+ L L N+++ L G + +
Sbjct: 374 RGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAK-GTFTSLRAIQ 432
Query: 229 ELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPRRL 288
L L +NP+ +C+ C +
Sbjct: 433 TLHLAQNPF-------------------------ICD------------------CNLKW 449
Query: 289 ISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQ 348
++D+ L T P + TS + P K Q + R ++++
Sbjct: 450 LADF-------------LRTNP-----IETSGARCASPRRLANKRIGQIKSKKFRCSAKE 491
Query: 349 PSKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKP 408
G +Y ++ + CP C C + V C K+ I E P+
Sbjct: 492 QYFIPGTEDY----QLNSECNSDVVCPHKCRCEANV------VECSSLKLTKIPERIPQ- 540
Query: 409 YNPKKMYLTENYIAVVRRTD-FLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGN 467
+ ++ L N I+++ T F + T L ++L NN++S I+D AF ++ L+L N
Sbjct: 541 -STAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTAN 599
Query: 468 RIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSG 527
++E + +F GL L+ L L+ N I I + +F + N++LL L +N + + G F
Sbjct: 600 QLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAF-- 657
Query: 528 LTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVGVLV 587
D L+SL ++L NP++C C + + W+ + K ++
Sbjct: 658 ----------------------DTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRK--IVT 693
Query: 588 DEVICKAPKKFAETDMRSIK-SELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLNS 645
C+ P + ++ + + C + + P P Q P + + VR ++
Sbjct: 694 GNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRP---QCPQECACLDTVVRCSN 749
Score = 104 bits (259), Expect = 5e-22
Identities = 118/475 (24%), Positives = 178/475 (37%), Gaps = 92/475 (19%)
Query: 48 CDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGA 107
C C C +GI V C +G+ ++ P L L+G + + P F Y
Sbjct: 282 CPAMCTCS--NGI--VDCRGKGLTAIPANLPETMTEIRLELNG--IKSIPPGAFSPYRKL 335
Query: 108 SILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISV 167
+ L +N I +I AF GLR L L L NK+ L F GL L+ L ++ N I+
Sbjct: 336 RRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINC 395
Query: 168 IEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMDKV 227
I P+AF L L +L L DN + SL G + +
Sbjct: 396 IRPDAFQDLQNLSLLSLYDNKIQSLAK------------------------GTFTSLRAI 431
Query: 228 VELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEV-SKQELCPR 286
L L +NP+ C C L L D+L + C +P RL + + ++ SK+ C
Sbjct: 432 QTLHLAQNPFICDCNLKWLADFLRTNPIE--TSGARCASPRRLANKRIGQIKSKKFRCSA 489
Query: 287 RL------ISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKP 340
+ DY++ + S H N V SS + K P + P+ T +
Sbjct: 490 KEQYFIPGTEDYQLNSECN-SDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAE---- 544
Query: 341 RVRPTSRQPSKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIES 400
L +N E I
Sbjct: 545 ------------------------------------------------LRLNNNEISILE 556
Query: 401 IAELQPKPYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLR 460
+ K + KK+ L+ N ++ + F A + LHL N++ I+ F L LR
Sbjct: 557 ATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLR 616
Query: 461 RLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNN 515
L L NRI + + F GL++++ L L N I + G FD + +L L L N
Sbjct: 617 TLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLAN 671
Score = 102 bits (254), Expect = 2e-21
Identities = 117/443 (26%), Positives = 173/443 (39%), Gaps = 36/443 (8%)
Query: 50 NACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGASI 109
+ACP TV C G+ ++ + P L L+GN + R++ N+F +
Sbjct: 32 SACPALCTCTGTTVDCHGTGLQAIPKNIPRNTE--RLELNGNNITRIHKNDFAGLKQLRV 89
Query: 110 LHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIE 169
L L N I +E GAF ++ L RL LN N+L +L + F + L L + N I I
Sbjct: 90 LQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIP 149
Query: 170 PNAFGKLHLLQVLILNDNLLSSLPNNLFRFV-PLTHLDLRGNRLKLLPYVGLLQHMDKVV 228
AF L+ L L+ N +S + FR + L L L N + +P V HM K+
Sbjct: 150 RKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIP-VSSFNHMPKLR 208
Query: 229 ELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPRRL 288
+L N C C L L WL L C P L G ++ EV K
Sbjct: 209 TFRLHSNHLFCDCHLAWLSQWLRQRPTIGLF--TQCSGPASLRGLNVAEVQK-------- 258
Query: 289 ISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQ 348
S++ Q + S ++ T S+ + K N P R
Sbjct: 259 -SEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAI-PANLPETMTEIRL 316
Query: 349 PSKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKP 408
+ G Y+ + L N QI+++ + R + S+
Sbjct: 317 ELNGIKSIPPGAFSPYRKLRRIDLS-------NNQIAEIAPDAFQGLRSLNSLV------ 363
Query: 409 YNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNR 468
L N I + R F L LL L N+I+ I+ AF DL NL L L N+
Sbjct: 364 -------LYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNK 416
Query: 469 IERLSPELFYGLQSLQYLFLQYN 491
I+ L+ F L+++Q L L N
Sbjct: 417 IQSLAKGTFTSLRAIQTLHLAQN 439
Score = 99.0 bits (245), Expect = 2e-20
Identities = 119/485 (24%), Positives = 195/485 (40%), Gaps = 66/485 (13%)
Query: 129 RGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNL 188
R RL LN N + + + F GL+ L LQ+ N I +E AF + L+ L LN N
Sbjct: 61 RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQ 120
Query: 189 LSSLPNNLFRF-VPLTHLDLRGNRLKLLPYVGLLQHMDKVVELQLEENPWNCSCELISLK 247
L LP LF+ L+ LDL N ++ +P D + LQL++N +C
Sbjct: 121 LHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATD-LKNLQLDKNQISC-------- 171
Query: 248 DWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPRRLISDYEMRPQTPLSTTGYLH 307
++ ++ AL G V L+ ++ + +S + P+ T LH
Sbjct: 172 --IEEGAFRALRGLEV----LTLNNNNITTIP---------VSSFNHMPKL---RTFRLH 213
Query: 308 TTP--ASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQPSKDLGYSNYGPSIAYQ 365
+ + S +P + P R + + S G +
Sbjct: 214 SNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVP 273
Query: 366 TKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVR 425
T + CP C+C+ I V+C+ + + +I P+ ++ L N I +
Sbjct: 274 TCTLSSGSCPAMCTCSNGI------VDCRGKGLTAIPANLPETMTEIRLEL--NGIKSIP 325
Query: 426 RTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQY 485
F L + L NN+I+ I AF L +L L L GN+I L +F GL +LQ
Sbjct: 326 PGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQL 385
Query: 486 LFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLRLNLRSNHFTSLPV 545
L L N I I+ F + NL LL L +N +Q++ G F+
Sbjct: 386 LLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFT------------------- 426
Query: 546 SGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVG-VLVDEVICKAPKKFAETDMR 604
L+++ + L NP+ C C+ +K + L+ + C +P++ A +
Sbjct: 427 -----SLRAIQTLHLAQNPFICDCN---LKWLADFLRTNPIETSGARCASPRRLANKRIG 478
Query: 605 SIKSE 609
IKS+
Sbjct: 479 QIKSK 483
Score = 98.2 bits (243), Expect = 3e-20
Identities = 80/281 (28%), Positives = 122/281 (43%), Gaps = 16/281 (5%)
Query: 374 CPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLEAT 433
CP C+C G V+C +++I + P+ N +++ L N I + + DF
Sbjct: 34 CPALCTCT------GTTVDCHGTGLQAIPKNIPR--NTERLELNGNNITRIHKNDFAGLK 85
Query: 434 GLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLI 493
L +L L N+I ++ AF D+ L RL LN N++ L LF Q+L L L N I
Sbjct: 86 QLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAI 145
Query: 494 REIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLR-LNLRSNHFTSLPVSGVLDQL 552
+ I F +L+ L L+ N + + G F L L L L +N+ T++PVS + +
Sbjct: 146 QAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSS-FNHM 204
Query: 553 KSLIQIDLHDNPWDCTCDIVGMKLWVEQL-KVGVLVDEVICKAPKKFAETDMRSI-KSEL 610
L LH N C C + + W+ Q +G+ C P ++ + KSE
Sbjct: 205 PKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQ---CSGPASLRGLNVAEVQKSEF 261
Query: 611 LCPDYSDV-VVSTPTPSSIQVPARTSAVTPAVRLNSTGAPA 650
C + V T T SS PA + V G A
Sbjct: 262 SCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTA 302
Score = 76.3 bits (186), Expect = 1e-13
Identities = 65/236 (27%), Positives = 103/236 (43%), Gaps = 37/236 (15%)
Query: 47 ICDNACPCEEKDGILTVSCENRGIISLSEISPPRFP--IYHLLLSGNLLNRLYPNE-FVN 103
+C + C CE V C + + L++I P R P L L+ N ++ L F
Sbjct: 512 VCPHKCRCEAN----VVECSS---LKLTKI-PERIPQSTAELRLNNNEISILEATGMFKK 563
Query: 104 YTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYN 163
T ++L +N + +IE GAF G + LHL N+LE +R F GL+ L L + N
Sbjct: 564 LTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNN 623
Query: 164 YISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQH 223
IS I ++F L +++L L DN ++++ G
Sbjct: 624 RISCIHNDSFTGLRNVRLLSLYDNQITTVS------------------------PGAFDT 659
Query: 224 MDKVVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVS 279
+ + L L NP+NC+C+L L WL + G+ C+ P L L +V+
Sbjct: 660 LQSLSTLNLLANPFNCNCQLAWLGGWLR--KRKIVTGNPRCQNPDFLRQIPLQDVA 713
Score = 61.6 bits (148), Expect = 3e-09
Identities = 44/145 (30%), Positives = 71/145 (48%), Gaps = 9/145 (6%)
Query: 373 ECPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLEA 432
+CP C+C L V C + + ++ + PK N ++YL N +V
Sbjct: 733 QCPQECAC------LDTVVRCSNKHLRALPKGIPK--NVTELYLDGNQFTLVPG-QLSTF 783
Query: 433 TGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNL 492
L L+ L NN+IS + + +F +++ L L L+ N ++ + P F GL+SL+ L L N
Sbjct: 784 KYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGND 843
Query: 493 IREIQSGTFDPVPNLQLLFLNNNLL 517
I +Q G F V +L L + N L
Sbjct: 844 ISTLQEGIFADVTSLSHLAIGANPL 868
Score = 56.6 bits (135), Expect = 1e-07
Identities = 39/123 (31%), Positives = 60/123 (48%), Gaps = 3/123 (2%)
Query: 458 NLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLL 517
N+ LYL+GN+ L P + LQ + L N I + + +F + L L L+ N L
Sbjct: 762 NVTELYLDGNQFT-LVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNAL 820
Query: 518 QAMPSGVFSGLTLLR-LNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKL 576
Q +P F GL LR L+L N ++L G+ + SL + + NP C C + +
Sbjct: 821 QCIPPLAFQGLRSLRLLSLHGNDISTLQ-EGIFADVTSLSHLAIGANPLYCDCHLRWLSS 879
Query: 577 WVE 579
WV+
Sbjct: 880 WVK 882
Score = 47.0 bits (110), Expect = 9e-05
Identities = 30/91 (32%), Positives = 48/91 (52%), Gaps = 1/91 (1%)
Query: 123 GAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVL 182
G + L+ + L+NNK+ L + +F + L L + YN + I P AF L L++L
Sbjct: 778 GQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLL 837
Query: 183 ILNDNLLSSLPNNLFRFV-PLTHLDLRGNRL 212
L+ N +S+L +F V L+HL + N L
Sbjct: 838 SLHGNDISTLQEGIFADVTSLSHLAIGANPL 868
Score = 45.4 bits (106), Expect = 2e-04
Identities = 26/76 (34%), Positives = 40/76 (52%)
Query: 88 LSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDD 147
LS N ++ L + F N + + L L N +Q I AF GLR LR L L+ N + L++
Sbjct: 791 LSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEG 850
Query: 148 TFLGLENLEYLQVDYN 163
F + +L +L + N
Sbjct: 851 IFADVTSLSHLAIGAN 866
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 114 bits (286), Expect = 3e-25
Identities = 123/541 (22%), Positives = 221/541 (40%), Gaps = 104/541 (19%)
Query: 110 LHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIE 169
+ L N I+ I GAF + LRR+ L+NN++ L D F GL +L L + N I+ +
Sbjct: 305 IRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELP 364
Query: 170 PNAFGKLHLLQVLILNDNLLSSLPNNLFRFVP-LTHLDLRGNRLKLLPYVGLLQHMDKVV 228
+ F L LQ+L+LN N ++ L + F+ + L L L N+L+ + G + +
Sbjct: 365 KSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAK-GTFSPLRAIQ 423
Query: 229 ELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPRRL 288
+ L +NP+ +C+ C +
Sbjct: 424 TMHLAQNPF-------------------------ICD------------------CHLKW 440
Query: 289 ISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQ 348
++DY LHT P + TS + P K Q + R ++++
Sbjct: 441 LADY-------------LHTNP-----IETSGARCTSPRRLANKRIGQIKSKKFRCSAKE 482
Query: 349 PSKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKP 408
G +Y ++ + L CP C C G V+C +K+ I E P+
Sbjct: 483 QYFIPGTEDYRSKLSGDCFAD--LACPEKCRCE------GTTVDCSNQKLNKIPEHIPQ- 533
Query: 409 YNPKKMYLTENYIAVVRRTD-FLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGN 467
++ L N V+ T F + L ++ NN+I+ I++ AF + + + L N
Sbjct: 534 -YTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSN 592
Query: 468 RIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSG 527
R+E + ++F GL+SL+ L L+ N I + + +F + +++LL L +N + + G F
Sbjct: 593 RLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAF-- 650
Query: 528 LTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVGVLV 587
D L SL ++L NP++C C + + W+ K ++
Sbjct: 651 ----------------------DTLHSLSTLNLLANPFNCNCYLAWLGEWLR--KKRIVT 686
Query: 588 DEVICKAPKKFAETDMRSIK-SELLCPDYSDVVVSTPTPSSIQVPARTSAVTPAVRLNST 646
C+ P E ++ + + C D +D +P + P + + VR ++
Sbjct: 687 GNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLS---RCPTECTCLDTVVRCSNK 743
Query: 647 G 647
G
Sbjct: 744 G 744
Score = 106 bits (265), Expect = 9e-23
Identities = 121/460 (26%), Positives = 177/460 (38%), Gaps = 39/460 (8%)
Query: 33 LVLSCAETIDYYGEICDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNL 92
L LS + ++ ACP + TV C + S+ P L L+GN
Sbjct: 9 LSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTE--RLDLNGNN 66
Query: 93 LNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGL 152
+ R+ +F +L L N I IE GAF L+ L RL LN N L+L + FLG
Sbjct: 67 ITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGT 126
Query: 153 ENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFV-PLTHLDLRGNR 211
L L + N I I AF ++ L L+ N +S + + FR + L L L N
Sbjct: 127 AKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNN 186
Query: 212 LKLLPYVGLLQHMDKVVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLH 271
+ L V HM K+ +L N C C L L DWL L C P L
Sbjct: 187 ITRLS-VASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLY--TQCMGPSHLR 243
Query: 272 GRDLDEVSKQELCPRRLISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPP 331
G ++ EV K+E + S ++ S S N V + + P
Sbjct: 244 GHNVAEVQKREF----VCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIP---- 295
Query: 332 KGTRQPNKPRVRPTSRQPSKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNV 391
N P R + G Y+ + L N QIS+L +
Sbjct: 296 -----TNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLS-------NNQISELAPDA 343
Query: 392 NCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDR 451
R + S+ L N I + ++ F L LL L N+I+ ++
Sbjct: 344 FQGLRSLNSLV-------------LYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVD 390
Query: 452 AFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYN 491
AF DL NL L L N+++ ++ F L+++Q + L N
Sbjct: 391 AFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQN 430
Score = 100 bits (250), Expect = 5e-21
Identities = 125/487 (25%), Positives = 197/487 (40%), Gaps = 73/487 (14%)
Query: 129 RGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNL 188
R RL LN N + + F GL +L LQ+ N IS IE AF L L+ L LN N
Sbjct: 55 RNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNH 114
Query: 189 LSSLPNNLFR-FVPLTHLDLRGNRLKLLPYVGLLQHMDKVVELQLEENPWNCSCELISLK 247
L P LF L LDL N+++ +P +D + LQL+ N SC
Sbjct: 115 LQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVD-IKNLQLDYN--QISC------ 165
Query: 248 DWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPRRL-ISDYEMRPQTPLSTTGYL 306
++ ++ AL RDL+ ++ RL ++ + P+ T L
Sbjct: 166 --IEDGAFRAL--------------RDLEVLTLNNNNITRLSVASFNHMPKL---RTFRL 206
Query: 307 HTTP--ASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQPSKDLGYSNYGPSIAY 364
H+ + S +P + P+ R + ++ S + ++
Sbjct: 207 HSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQ---SF 263
Query: 365 QTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVV 424
S L CP AC+C+ I V+C+ + + I P+ +TE
Sbjct: 264 MAPSCSVLHCPAACTCSNNI------VDCRGKGLTEIPTNLPET-------ITE------ 304
Query: 425 RRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQ 484
+ L N I +I AF LRR+ L+ N+I L+P+ F GL+SL
Sbjct: 305 -------------IRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLN 351
Query: 485 YLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGL-TLLRLNLRSNHFTSL 543
L L N I E+ F+ + +LQLL LN N + + F L L L+L N ++
Sbjct: 352 SLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTI 411
Query: 544 PVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVG-VLVDEVICKAPKKFAETD 602
G L+++ + L NP+ C C +K + L + C +P++ A
Sbjct: 412 -AKGTFSPLRAIQTMHLAQNPFICDCH---LKWLADYLHTNPIETSGARCTSPRRLANKR 467
Query: 603 MRSIKSE 609
+ IKS+
Sbjct: 468 IGQIKSK 474
Score = 94.7 bits (234), Expect = 4e-19
Identities = 77/265 (29%), Positives = 117/265 (44%), Gaps = 17/265 (6%)
Query: 371 PLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFL 430
P CP CSC+ G V+C + S+ P+ N +++ L N I + +TDF
Sbjct: 25 PQACPAQCSCS------GSTVDCHGLALRSVPRNIPR--NTERLDLNGNNITRITKTDFA 76
Query: 431 EATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQY 490
L +L L N+IS I+ AF DL L RL LN N ++ LF G L L L
Sbjct: 77 GLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSE 136
Query: 491 NLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLR-LNLRSNHFTSLPVSGVL 549
N I+ I F +++ L L+ N + + G F L L L L +N+ T L V+
Sbjct: 137 NQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVAS-F 195
Query: 550 DQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQL-KVGVLVDEVICKAPKKFAETDMRSI-K 607
+ + L LH N C C + + W+ Q +VG+ C P ++ + K
Sbjct: 196 NHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQ---CMGPSHLRGHNVAEVQK 252
Query: 608 SELLCPDYSDVVVSTPTPSSIQVPA 632
E +C + + P+ S + PA
Sbjct: 253 REFVCSGHQSFM--APSCSVLHCPA 275
Score = 73.6 bits (179), Expect = 9e-13
Identities = 59/235 (25%), Positives = 94/235 (40%), Gaps = 32/235 (13%)
Query: 48 CDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGA 107
C AC C V C +G+ + P I + L N + + P F Y
Sbjct: 273 CPAACTCSNN----IVDCRGKGLTEIPTNLPET--ITEIRLEQNTIKVIPPGAFSPYKKL 326
Query: 108 SILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISV 167
+ L +N I ++ AF GLR L L L NK+ L F GL +L+ L ++ N I+
Sbjct: 327 RRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINC 386
Query: 168 IEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMDKV 227
+ +AF LH L +L L DN L ++ G + +
Sbjct: 387 LRVDAFQDLHNLNLLSLYDNKLQTIAK------------------------GTFSPLRAI 422
Query: 228 VELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQE 282
+ L +NP+ C C L L D+L + C +P RL + + ++ ++
Sbjct: 423 QTMHLAQNPFICDCHLKWLADYLHTNPIE--TSGARCTSPRRLANKRIGQIKSKK 475
Score = 73.2 bits (178), Expect = 1e-12
Identities = 64/244 (26%), Positives = 103/244 (42%), Gaps = 49/244 (20%)
Query: 48 CDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGA 107
C C CE TV C N+ + + P P Y L RL NEF
Sbjct: 506 CPEKCRCEGT----TVDCSNQKLNKI----PEHIPQYTAEL------RLNNNEFTVLEAT 551
Query: 108 SI---------LHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYL 158
I ++ +N I DIE GAF G G+ + L +N+LE ++ F GLE+L+ L
Sbjct: 552 GIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTL 611
Query: 159 QVDYNYISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYV 218
+ N I+ + ++F L +++L L DN ++++
Sbjct: 612 MLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVA------------------------P 647
Query: 219 GLLQHMDKVVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEV 278
G + + L L NP+NC+C L L +WL + G+ C+ P+ L + +V
Sbjct: 648 GAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLR--KKRIVTGNPRCQKPYFLKEIPIQDV 705
Query: 279 SKQE 282
+ Q+
Sbjct: 706 AIQD 709
Score = 65.9 bits (159), Expect = 2e-10
Identities = 49/170 (28%), Positives = 81/170 (47%), Gaps = 10/170 (5%)
Query: 349 PSKDLGYSNYGPSIAYQTKSPVPLE-CPTACSCNLQISDLGLNVNCQERKIESIAELQPK 407
P +D+ ++ S PL CPT C+C L V C + ++ + + P+
Sbjct: 701 PIQDVAIQDFTCDDGNDDNSCSPLSRCPTECTC------LDTVVRCSNKGLKVLPKGIPR 754
Query: 408 PYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGN 467
++YL N +V + + L L+ L NNRIS + +++F ++T L L L+ N
Sbjct: 755 DVT--ELYLDGNQFTLVPK-ELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYN 811
Query: 468 RIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLL 517
R+ + P F GL+SL+ L L N I + G F+ + L L + N L
Sbjct: 812 RLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPL 861
Score = 59.3 bits (142), Expect = 2e-08
Identities = 44/144 (30%), Positives = 65/144 (45%), Gaps = 11/144 (7%)
Query: 48 CDNACPCEEKDGILTVSCENRGIISLSEISPPRFP--IYHLLLSGNLLNRLYPNEFVNYT 105
C C C + V C N+G+ ++ P P + L L GN L P E NY
Sbjct: 727 CPTECTCLDT----VVRCSNKGL----KVLPKGIPRDVTELYLDGNQFT-LVPKELSNYK 777
Query: 106 GASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYI 165
+++ L +N I + +F + L L L+ N+L + TF GL++L L + N I
Sbjct: 778 HLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDI 837
Query: 166 SVIEPNAFGKLHLLQVLILNDNLL 189
SV+ AF L L L + N L
Sbjct: 838 SVVPEGAFNDLSALSHLAIGANPL 861
Score = 53.5 bits (127), Expect = 9e-07
Identities = 43/151 (28%), Positives = 72/151 (47%), Gaps = 7/151 (4%)
Query: 431 EATGLD-LLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQ 489
E T LD ++ N + ++ D+T L YL+GN+ L P+ + L + L
Sbjct: 730 ECTCLDTVVRCSNKGLKVLPKGIPRDVTEL---YLDGNQFT-LVPKELSNYKHLTLIDLS 785
Query: 490 YNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLR-LNLRSNHFTSLPVSGV 548
N I + + +F + L L L+ N L+ +P F GL LR L+L N + +P G
Sbjct: 786 NNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVP-EGA 844
Query: 549 LDQLKSLIQIDLHDNPWDCTCDIVGMKLWVE 579
+ L +L + + NP C C++ + WV+
Sbjct: 845 FNDLSALSHLAIGANPLYCDCNMQWLSDWVK 875
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 111 bits (278), Expect = 3e-24
Identities = 118/448 (26%), Positives = 182/448 (40%), Gaps = 50/448 (11%)
Query: 51 ACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGASIL 110
ACP + +V C G+ ++ P L L N + R+ +F +L
Sbjct: 33 ACPTKCTCSAASVDCHGLGLRAVPRGIPRNAE--RLDLDRNNITRITKMDFAGLKNLRVL 90
Query: 111 HLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEP 170
HL N + IE GAF L+ L RL LN NKL++L + F L L + N I I
Sbjct: 91 HLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPR 150
Query: 171 NAFGKLHLLQVLILNDNLLSSLPNNLFRFV-PLTHLDLRGNRLKLLPYVGLLQHMDKVVE 229
AF + ++ L L++N +S + + FR + L L L N + + V HM K+
Sbjct: 151 KAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRI-LVTSFNHMPKIRT 209
Query: 230 LQLEENPWNCSCELISLKDWLDSISYSALVGD-VVCETPFRLHGRDLDEVSKQE-LCPRR 287
L+L N C C L L DWL VG +C P L G ++ +V K+E +CP
Sbjct: 210 LRLHSNHLYCDCHLAWLSDWL---RQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCP-- 264
Query: 288 LISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPTSR 347
+ + P ++ S N V + + P P+G + R+ S
Sbjct: 265 --APHSEPPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVE---IRLEQNSI 319
Query: 348 QPSKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPK 407
+ ++ Y L+ D+ N I+++ P
Sbjct: 320 KAIPAGAFTQYK---------------------KLKRIDISKN---------QISDIAPD 349
Query: 408 PYNPKK----MYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLY 463
+ K + L N I + + F L LL L N+I+ ++ F DL NL L
Sbjct: 350 AFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLS 409
Query: 464 LNGNRIERLSPELFYGLQSLQYLFLQYN 491
L N+++ +S LF LQS+Q L L N
Sbjct: 410 LYDNKLQTISKGLFAPLQSIQTLHLAQN 437
Score = 108 bits (271), Expect = 2e-23
Identities = 111/476 (23%), Positives = 198/476 (41%), Gaps = 106/476 (22%)
Query: 110 LHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIE 169
+ L N I+ I GAF + L+R+ ++ N++ + D F GL++L L + N I+ I
Sbjct: 312 IRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIA 371
Query: 170 PNAFGKLHLLQVLILNDNLLSSLPNNLFRFVP-LTHLDLRGNRLKLLPYVGLLQHMDKVV 228
F L LQ+L+LN N ++ L N F+ + L L L N+L+ + GL + +
Sbjct: 372 KGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISK-GLFAPLQSIQ 430
Query: 229 ELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPRRL 288
L L +NP+ VC+ C +
Sbjct: 431 TLHLAQNPF-------------------------VCD------------------CHLKW 447
Query: 289 ISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQ 348
++DY P+ T+G ++P R NK R+ +
Sbjct: 448 LADYLQ--DNPIETSGARCSSPR-----------------------RLANK-RISQIKSK 481
Query: 349 PSKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKP 408
+ G +Y + ++ + L CP C C G V+C +K+ I P+
Sbjct: 482 KFRCSGSEDYRSR--FSSECFMDLVCPEKCRCE------GTIVDCSNQKLVRIPSHLPEY 533
Query: 409 YNPKKMYLTENYIAVVRRTD-FLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGN 467
+ L +N ++V+ T F + L ++L NN+I +++ AF +++ L L GN
Sbjct: 534 VTDLR--LNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGN 591
Query: 468 RIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSG 527
++E + +F GL L+ L L+ NLI + + TF + +++LL L +N + + G F+
Sbjct: 592 QLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTT 651
Query: 528 LTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKV 583
L SL I+L NP++C C + + W+ + ++
Sbjct: 652 LV------------------------SLSTINLLSNPFNCNCHLAWLGKWLRKRRI 683
Score = 97.4 bits (241), Expect = 6e-20
Identities = 72/256 (28%), Positives = 119/256 (46%), Gaps = 15/256 (5%)
Query: 361 SIAYQTKSPVPLECPTACSCNLQISDL-GLNVNCQERKIESIAELQPKPYNPKKMYLTEN 419
++A P + CPT C+C+ D GL + R I P N +++ L N
Sbjct: 21 ALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGI---------PRNAERLDLDRN 71
Query: 420 YIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYG 479
I + + DF L +LHL +N++S+I+ AF DL L RL LN N+++ L LF
Sbjct: 72 NITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQS 131
Query: 480 LQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLR-LNLRSN 538
L L L N I+ I F + +++ L L+NN + + G F L L L L +N
Sbjct: 132 TPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNN 191
Query: 539 HFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPKKF 598
+ + + V+ + + + + LH N C C + + W+ Q + + +C AP
Sbjct: 192 NISRILVTS-FNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRR--TVGQFTLCMAPVHL 248
Query: 599 AETDMRSI-KSELLCP 613
++ + K E +CP
Sbjct: 249 RGFNVADVQKKEYVCP 264
Score = 85.9 bits (211), Expect = 2e-16
Identities = 113/455 (24%), Positives = 171/455 (37%), Gaps = 82/455 (18%)
Query: 48 CDNACPCEEKDGILTVSCENRGIISLSEISPPRFP--IYHLLLSGNLLNRLYPNEFVNYT 105
C + C C V C +G++ + P P I + L N + + F Y
Sbjct: 280 CPSPCTCSNN----IVDCRGKGLMEI----PANLPEGIVEIRLEQNSIKAIPAGAFTQYK 331
Query: 106 GASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYI 165
+ + N I DI AF GL+ L L L NK+ + F GL +L+ L ++ N I
Sbjct: 332 KLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKI 391
Query: 166 SVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMD 225
+ + N F L L +L L DN L ++ L F PL
Sbjct: 392 NCLRVNTFQDLQNLNLLSLYDNKLQTISKGL--FAPL----------------------Q 427
Query: 226 KVVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEV-SKQELC 284
+ L L +NP+ C C L L D+L C +P RL + + ++ SK+ C
Sbjct: 428 SIQTLHLAQNPFVCDCHLKWLADYLQDNPIE--TSGARCSSPRRLANKRISQIKSKKFRC 485
Query: 285 PRRLISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPK----GT--RQPN 338
DY R SS + + P K GT N
Sbjct: 486 SGS--EDYRSR-----------------------FSSECFMDLVCPEKCRCEGTIVDCSN 520
Query: 339 KPRVRPTSRQPS--KDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQER 396
+ VR S P DL ++ S+ T + + P NL + + +E
Sbjct: 521 QKLVRIPSHLPEYVTDLRLNDNEVSVLEAT--GIFKKLPNLRKINLSNNKI---KEVREG 575
Query: 397 KIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDL 456
+ A +Q ++ LT N + V F +GL L L +N I + + F L
Sbjct: 576 AFDGAASVQ-------ELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGL 628
Query: 457 TNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYN 491
+++R L L NRI ++P F L SL + L N
Sbjct: 629 SSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSN 663
Score = 79.3 bits (194), Expect = 2e-14
Identities = 71/297 (23%), Positives = 122/297 (41%), Gaps = 58/297 (19%)
Query: 372 LECPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLE 431
+ CP+ C+C+ I V+C+ + + I P+ ++ L +N I + F +
Sbjct: 278 ISCPSPCTCSNNI------VDCRGKGLMEIPANLPE--GIVEIRLEQNSIKAIPAGAFTQ 329
Query: 432 ATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYN 491
L + + N+IS I AF L +L L L GN+I ++ LF GL SLQ L L N
Sbjct: 330 YKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNAN 389
Query: 492 LIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLRLNLRSNHFTSLPVSGVLDQ 551
I ++ TF + NL LL L +N LQ + G+F+
Sbjct: 390 KINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFA------------------------P 425
Query: 552 LKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPKKFAETDMRSIKS--- 608
L+S+ + L NP+ C C + + +++ + C +P++ A + IKS
Sbjct: 426 LQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIE--TSGARCSSPRRLANKRISQIKSKKF 483
Query: 609 ------------------ELLCPD---YSDVVVSTPTPSSIQVPARTSAVTPAVRLN 644
+L+CP+ +V +++P+ +RLN
Sbjct: 484 RCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLN 540
Score = 72.0 bits (175), Expect = 2e-12
Identities = 66/261 (25%), Positives = 108/261 (41%), Gaps = 38/261 (14%)
Query: 47 ICDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIY--HLLLSGNLLNRLYPNE-FVN 103
+C C CE V C N+ ++ + P P Y L L+ N ++ L F
Sbjct: 504 VCPEKCRCEGT----IVDCSNQKLVRI----PSHLPEYVTDLRLNDNEVSVLEATGIFKK 555
Query: 104 YTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYN 163
++L +N I+++ GAF G ++ L L N+LE + F GL L+ L + N
Sbjct: 556 LPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSN 615
Query: 164 YISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQH 223
I + + F L +++L L DN ++++ F L L + LL
Sbjct: 616 LIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAF------------TTLVSLSTINLL-- 661
Query: 224 MDKVVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQEL 283
NP+NC+C L L WL + G+ C+ PF L + +V+ Q+
Sbjct: 662 ----------SNPFNCNCHLAWLGKWLR--KRRIVSGNPRCQKPFFLKEIPIQDVAIQDF 709
Query: 284 -CPRRLISDYEMRPQTPLSTT 303
C S ++ P+ P T
Sbjct: 710 TCDGNEESSCQLSPRCPEQCT 730
Score = 65.5 bits (158), Expect = 2e-10
Identities = 45/169 (26%), Positives = 80/169 (47%), Gaps = 9/169 (5%)
Query: 349 PSKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKP 408
P +D+ ++ ++ + CP C+C + V C + + ++ PK
Sbjct: 700 PIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETV------VRCSNKGLRALPRGMPKD 753
Query: 409 YNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNR 468
++YL N++ V R + L L+ L NN ISM+ + F ++++L L L+ NR
Sbjct: 754 VT--ELYLEGNHLTAVPR-ELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNR 810
Query: 469 IERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLL 517
+ + F GL+SL+ L L N I + G+F+ + +L L L N L
Sbjct: 811 LRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPL 859
Score = 60.5 bits (145), Expect = 7e-09
Identities = 46/145 (31%), Positives = 70/145 (48%), Gaps = 7/145 (4%)
Query: 458 NLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLL 517
++ LYL GN + + EL L+ L + L N I + + TF + +L L L+ N L
Sbjct: 753 DVTELYLEGNHLTAVPRELS-ALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRL 811
Query: 518 QAMPSGVFSGLTLLR-LNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKL 576
+ +P F+GL LR L L N +S+P G + L SL + L NP C C + +
Sbjct: 812 RCIPVHAFNGLRSLRVLTLHGNDISSVP-EGSFNDLTSLSHLALGTNPLHCDCSLRWLSE 870
Query: 577 WVEQLKVGVLVDEVI-CKAPKKFAE 600
WV K G + C +P+ A+
Sbjct: 871 WV---KAGYKEPGIARCSSPEPMAD 892
Score = 57.4 bits (137), Expect = 6e-08
Identities = 55/203 (27%), Positives = 77/203 (37%), Gaps = 55/203 (27%)
Query: 48 CDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGA 107
C C C E V C N+G+ +L P + L L GN L + P E
Sbjct: 725 CPEQCTCMET----VVRCSNKGLRALPRGMPK--DVTELYLEGNHLTAV-PREL------ 771
Query: 108 SILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISV 167
LR L + L+NN + +L + TF + +L L + YN +
Sbjct: 772 ------------------SALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRC 813
Query: 168 IEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMDKV 227
I +AF L L+VL L+ N +SS+P F LT L
Sbjct: 814 IPVHAFNGLRSLRVLTLHGNDISSVPEGSFN--DLTSLS--------------------- 850
Query: 228 VELQLEENPWNCSCELISLKDWL 250
L L NP +C C L L +W+
Sbjct: 851 -HLALGTNPLHCDCSLRWLSEWV 872
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 107 bits (267), Expect = 5e-23
Identities = 78/265 (29%), Positives = 125/265 (47%), Gaps = 29/265 (10%)
Query: 83 IYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLE 142
+ L LS N +++L P+ F+ + L L N ++++ G F + LR L L +N +
Sbjct: 253 LQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHIS 312
Query: 143 LLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVP- 201
L D+ F L L+ L + N IS I P AF L L+ L L+ N L L N+FR +
Sbjct: 313 SLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLAN 372
Query: 202 LTHLDLRGNRLKLLP-----------------------YVGLLQHMDKVVELQLEENPWN 238
L ++ L+ NRL+ LP +G+ H+ K+ EL+L +NPW
Sbjct: 373 LQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWR 432
Query: 239 CSCELISLKDWLDSISYSALVGDV--VCETPFRLHGRDLDEVSKQELCPRRLISDYEMRP 296
C +++ L++WL ++ L D VC +P + G+ L ++ P + + P
Sbjct: 433 CDSDILPLRNWL-LLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPEVPSYP 491
Query: 297 QTPL--STTGYLHTTPASVNSVATS 319
+TP T Y TT S + TS
Sbjct: 492 ETPWYPDTPSYPDTTSVSSTTELTS 516
Score = 96.3 bits (238), Expect = 1e-19
Identities = 64/219 (29%), Positives = 108/219 (49%), Gaps = 32/219 (14%)
Query: 391 VNCQERKIES--IAELQP----KPYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNR 444
VN QE ++ I L P +N +++YL+ N+I+ + + F++ L+ L L N
Sbjct: 227 VNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNS 286
Query: 445 ISMIQDRAFGDLTNLRRLYLNGNRIERL------------------------SPELFYGL 480
+ + FG + NLR L+L N I L SP F GL
Sbjct: 287 LKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGL 346
Query: 481 QSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLT-LLRLNLRSNH 539
L+ L L N ++++ F + NLQ + L NN L+ +P +F+ + L+ + L++N
Sbjct: 347 TELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQ 406
Query: 540 FTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWV 578
+LP+ G+ D L L ++ L+DNPW C DI+ ++ W+
Sbjct: 407 LENLPL-GIFDHLGKLCELRLYDNPWRCDSDILPLRNWL 444
Score = 86.7 bits (213), Expect = 1e-16
Identities = 65/212 (30%), Positives = 100/212 (47%), Gaps = 16/212 (7%)
Query: 353 LGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPK 412
+G +G +AY CP+ C+C+ V C +I +A P P+N
Sbjct: 17 VGCQAWGAGLAYHG-------CPSECTCSR-----ASQVECTGARI--VAVPTPLPWNAM 62
Query: 413 KMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERL 472
+ + +I + + FL + L L + N +S I AF +L +LR L L N+++ L
Sbjct: 63 SLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVL 122
Query: 473 SPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLT-LL 531
LF GL SL+ L L N + +IQ F NL+ L L+ N L+ +P G F L L
Sbjct: 123 PIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLT 182
Query: 532 RLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDN 563
+LNL N T + V L +L + L++N
Sbjct: 183 KLNLGKNSLTHIS-PRVFQHLGNLQVLRLYEN 213
Score = 84.0 bits (206), Expect = 6e-16
Identities = 53/168 (31%), Positives = 86/168 (51%), Gaps = 4/168 (2%)
Query: 400 SIAELQPKPY----NPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGD 455
S+ + P+ + N + + L EN + + F L L L N+I ++ F +
Sbjct: 190 SLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHN 249
Query: 456 LTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNN 515
NL+RLYL+ N I +L P +F L L L L N ++E+ G F P+PNL+ L+L +N
Sbjct: 250 NHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN 309
Query: 516 LLQAMPSGVFSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDN 563
+ ++P VFS L L++ + S + S G + L L ++ LH N
Sbjct: 310 HISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTN 357
Score = 79.3 bits (194), Expect = 2e-14
Identities = 59/186 (31%), Positives = 90/186 (48%), Gaps = 8/186 (4%)
Query: 412 KKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIER 471
+ + L+ N + ++ F + + L L L N + I D AF L L +L L N +
Sbjct: 134 ESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTH 193
Query: 472 LSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVF-SGLTL 530
+SP +F L +LQ L L N + +I GTFD + NLQ L L N + + G+F + L
Sbjct: 194 ISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNL 253
Query: 531 LRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPW-DCTCDIVG-----MKLWVEQLKVG 584
RL L +NH + LP S + QL L ++ L N + + I G +LW+ +
Sbjct: 254 QRLYLSNNHISQLPPS-IFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHIS 312
Query: 585 VLVDEV 590
L D V
Sbjct: 313 SLPDNV 318
Score = 76.3 bits (186), Expect = 1e-13
Identities = 63/191 (32%), Positives = 94/191 (49%), Gaps = 8/191 (4%)
Query: 401 IAELQPKPY----NPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDL 456
+ ++QP + N K++ L N++ + F GL L+LG N ++ I R F L
Sbjct: 143 LLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHL 202
Query: 457 TNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNL 516
NL+ L L NR+ + F GL +LQ L LQ N I + G F NLQ L+L+NN
Sbjct: 203 GNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNH 262
Query: 517 LQAMPSGVFSGLTLL-RLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMK 575
+ +P +F L L RL L N L + G+ + +L ++ L+DN D V
Sbjct: 263 ISQLPPSIFMQLPQLNRLTLFGNSLKELSL-GIFGPMPNLRELWLYDNHISSLPDNVFSN 321
Query: 576 LWVEQLKVGVL 586
L QL+V +L
Sbjct: 322 L--RQLQVLIL 330
Score = 76.3 bits (186), Expect = 1e-13
Identities = 59/168 (35%), Positives = 83/168 (49%), Gaps = 6/168 (3%)
Query: 73 LSEISPPRFP----IYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGL 128
L +I P F + L L GN L + F + G + L+LG N + I F L
Sbjct: 143 LLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHL 202
Query: 129 RGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNL 188
L+ L L N+L + TF GL NL+ L + N I ++ P F H LQ L L++N
Sbjct: 203 GNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNH 262
Query: 189 LSSLPNNLFRFVP-LTHLDLRGNRLKLLPYVGLLQHMDKVVELQLEEN 235
+S LP ++F +P L L L GN LK L +G+ M + EL L +N
Sbjct: 263 ISQLPPSIFMQLPQLNRLTLFGNSLKELS-LGIFGPMPNLRELWLYDN 309
Score = 72.8 bits (177), Expect = 1e-12
Identities = 61/195 (31%), Positives = 92/195 (47%), Gaps = 11/195 (5%)
Query: 43 YYGEICDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFV 102
Y+G C + C C V C I+++ +P + L + + L + F+
Sbjct: 28 YHG--CPSECTCSRAS---QVECTGARIVAVP--TPLPWNAMSLQILNTHITELNESPFL 80
Query: 103 NYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDY 162
N + L + N + I GAF L LR L L NNKL++L F GL++LE L +
Sbjct: 81 NISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSS 140
Query: 163 NYISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLF-RFVPLTHLDLRGNRL-KLLPYVGL 220
N + I+P F + L+ L L+ N L +P+ F V LT L+L N L + P V
Sbjct: 141 NQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRV-- 198
Query: 221 LQHMDKVVELQLEEN 235
QH+ + L+L EN
Sbjct: 199 FQHLGNLQVLRLYEN 213
Score = 59.3 bits (142), Expect = 2e-08
Identities = 54/168 (32%), Positives = 74/168 (44%), Gaps = 6/168 (3%)
Query: 73 LSEISPPRF----PIYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGL 128
LS I+P F + +L L+ N L L F L L SN + I+ F
Sbjct: 95 LSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQC 154
Query: 129 RGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNL 188
L+ L L+ N LE + D F L L L + N ++ I P F L LQVL L +N
Sbjct: 155 SNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENR 214
Query: 189 LSSLPNNLF-RFVPLTHLDLRGNRLKLLPYVGLLQHMDKVVELQLEEN 235
L+ +P F V L L L+ N++ LL GL + + L L N
Sbjct: 215 LTDIPMGTFDGLVNLQELALQQNQIGLLS-PGLFHNNHNLQRLYLSNN 261
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 107 bits (267), Expect = 5e-23
Identities = 78/265 (29%), Positives = 125/265 (47%), Gaps = 29/265 (10%)
Query: 83 IYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLE 142
+ L LS N +++L P+ F+ + L L N ++++ G F + LR L L +N +
Sbjct: 247 LQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHIS 306
Query: 143 LLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVP- 201
L D+ F L L+ L + N IS I P AF L L+ L L+ N L L N+FR +
Sbjct: 307 SLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLAN 366
Query: 202 LTHLDLRGNRLKLLP-----------------------YVGLLQHMDKVVELQLEENPWN 238
L ++ L+ NRL+ LP +G+ H+ K+ EL+L +NPW
Sbjct: 367 LQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWR 426
Query: 239 CSCELISLKDWLDSISYSALVGDV--VCETPFRLHGRDLDEVSKQELCPRRLISDYEMRP 296
C +++ L++WL ++ L D VC +P + G+ L ++ P + + P
Sbjct: 427 CDSDILPLRNWL-LLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPEVPSYP 485
Query: 297 QTPL--STTGYLHTTPASVNSVATS 319
+TP T Y TT S + TS
Sbjct: 486 ETPWYPDTPSYPDTTSVSSTTELTS 510
Score = 96.3 bits (238), Expect = 1e-19
Identities = 64/219 (29%), Positives = 108/219 (49%), Gaps = 32/219 (14%)
Query: 391 VNCQERKIES--IAELQP----KPYNPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNR 444
VN QE ++ I L P +N +++YL+ N+I+ + + F++ L+ L L N
Sbjct: 221 VNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNS 280
Query: 445 ISMIQDRAFGDLTNLRRLYLNGNRIERL------------------------SPELFYGL 480
+ + FG + NLR L+L N I L SP F GL
Sbjct: 281 LKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGL 340
Query: 481 QSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLT-LLRLNLRSNH 539
L+ L L N ++++ F + NLQ + L NN L+ +P +F+ + L+ + L++N
Sbjct: 341 TELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQ 400
Query: 540 FTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWV 578
+LP+ G+ D L L ++ L+DNPW C DI+ ++ W+
Sbjct: 401 LENLPL-GIFDHLGKLCELRLYDNPWRCDSDILPLRNWL 438
Score = 86.7 bits (213), Expect = 1e-16
Identities = 65/212 (30%), Positives = 100/212 (47%), Gaps = 16/212 (7%)
Query: 353 LGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPK 412
+G +G +AY CP+ C+C+ V C +I +A P P+N
Sbjct: 11 VGCQAWGAGLAYHG-------CPSECTCSR-----ASQVECTGARI--VAVPTPLPWNAM 56
Query: 413 KMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERL 472
+ + +I + + FL + L L + N +S I AF +L +LR L L N+++ L
Sbjct: 57 SLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVL 116
Query: 473 SPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLT-LL 531
LF GL SL+ L L N + +IQ F NL+ L L+ N L+ +P G F L L
Sbjct: 117 PIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLT 176
Query: 532 RLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDN 563
+LNL N T + V L +L + L++N
Sbjct: 177 KLNLGKNSLTHIS-PRVFQHLGNLQVLRLYEN 207
Score = 84.0 bits (206), Expect = 6e-16
Identities = 53/168 (31%), Positives = 86/168 (51%), Gaps = 4/168 (2%)
Query: 400 SIAELQPKPY----NPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGD 455
S+ + P+ + N + + L EN + + F L L L N+I ++ F +
Sbjct: 184 SLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHN 243
Query: 456 LTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNN 515
NL+RLYL+ N I +L P +F L L L L N ++E+ G F P+PNL+ L+L +N
Sbjct: 244 NHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN 303
Query: 516 LLQAMPSGVFSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDN 563
+ ++P VFS L L++ + S + S G + L L ++ LH N
Sbjct: 304 HISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTN 351
Score = 79.3 bits (194), Expect = 2e-14
Identities = 59/186 (31%), Positives = 90/186 (48%), Gaps = 8/186 (4%)
Query: 412 KKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIER 471
+ + L+ N + ++ F + + L L L N + I D AF L L +L L N +
Sbjct: 128 ESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTH 187
Query: 472 LSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVF-SGLTL 530
+SP +F L +LQ L L N + +I GTFD + NLQ L L N + + G+F + L
Sbjct: 188 ISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNL 247
Query: 531 LRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPW-DCTCDIVG-----MKLWVEQLKVG 584
RL L +NH + LP S + QL L ++ L N + + I G +LW+ +
Sbjct: 248 QRLYLSNNHISQLPPS-IFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHIS 306
Query: 585 VLVDEV 590
L D V
Sbjct: 307 SLPDNV 312
Score = 76.3 bits (186), Expect = 1e-13
Identities = 63/191 (32%), Positives = 94/191 (49%), Gaps = 8/191 (4%)
Query: 401 IAELQPKPY----NPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDL 456
+ ++QP + N K++ L N++ + F GL L+LG N ++ I R F L
Sbjct: 137 LLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHL 196
Query: 457 TNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNL 516
NL+ L L NR+ + F GL +LQ L LQ N I + G F NLQ L+L+NN
Sbjct: 197 GNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNH 256
Query: 517 LQAMPSGVFSGLTLL-RLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMK 575
+ +P +F L L RL L N L + G+ + +L ++ L+DN D V
Sbjct: 257 ISQLPPSIFMQLPQLNRLTLFGNSLKELSL-GIFGPMPNLRELWLYDNHISSLPDNVFSN 315
Query: 576 LWVEQLKVGVL 586
L QL+V +L
Sbjct: 316 L--RQLQVLIL 324
Score = 76.3 bits (186), Expect = 1e-13
Identities = 59/168 (35%), Positives = 83/168 (49%), Gaps = 6/168 (3%)
Query: 73 LSEISPPRFP----IYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGL 128
L +I P F + L L GN L + F + G + L+LG N + I F L
Sbjct: 137 LLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHL 196
Query: 129 RGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNL 188
L+ L L N+L + TF GL NL+ L + N I ++ P F H LQ L L++N
Sbjct: 197 GNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNH 256
Query: 189 LSSLPNNLFRFVP-LTHLDLRGNRLKLLPYVGLLQHMDKVVELQLEEN 235
+S LP ++F +P L L L GN LK L +G+ M + EL L +N
Sbjct: 257 ISQLPPSIFMQLPQLNRLTLFGNSLKELS-LGIFGPMPNLRELWLYDN 303
Score = 72.8 bits (177), Expect = 1e-12
Identities = 61/195 (31%), Positives = 92/195 (47%), Gaps = 11/195 (5%)
Query: 43 YYGEICDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFV 102
Y+G C + C C V C I+++ +P + L + + L + F+
Sbjct: 22 YHG--CPSECTCSRAS---QVECTGARIVAVP--TPLPWNAMSLQILNTHITELNESPFL 74
Query: 103 NYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDY 162
N + L + N + I GAF L LR L L NNKL++L F GL++LE L +
Sbjct: 75 NISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSS 134
Query: 163 NYISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLF-RFVPLTHLDLRGNRL-KLLPYVGL 220
N + I+P F + L+ L L+ N L +P+ F V LT L+L N L + P V
Sbjct: 135 NQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRV-- 192
Query: 221 LQHMDKVVELQLEEN 235
QH+ + L+L EN
Sbjct: 193 FQHLGNLQVLRLYEN 207
Score = 59.3 bits (142), Expect = 2e-08
Identities = 54/168 (32%), Positives = 74/168 (44%), Gaps = 6/168 (3%)
Query: 73 LSEISPPRF----PIYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGL 128
LS I+P F + +L L+ N L L F L L SN + I+ F
Sbjct: 89 LSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQC 148
Query: 129 RGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNL 188
L+ L L+ N LE + D F L L L + N ++ I P F L LQVL L +N
Sbjct: 149 SNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENR 208
Query: 189 LSSLPNNLF-RFVPLTHLDLRGNRLKLLPYVGLLQHMDKVVELQLEEN 235
L+ +P F V L L L+ N++ LL GL + + L L N
Sbjct: 209 LTDIPMGTFDGLVNLQELALQQNQIGLLS-PGLFHNNHNLQRLYLSNN 255
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 100 bits (249), Expect = 7e-21
Identities = 72/201 (35%), Positives = 109/201 (54%), Gaps = 9/201 (4%)
Query: 108 SILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISV 167
SIL L N I++I+ GAF LR L L LNNN+++ + F LENL+YL + N I
Sbjct: 65 SILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQS 124
Query: 168 IEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVP-LTHLDLRGNRL-KLLPYVGLLQHMD 225
I+ AF L L+ L L+ N + +L + F+ +P L L L NR+ L+P G H++
Sbjct: 125 IDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVP--GTFNHLE 182
Query: 226 KVVELQLEENPWNCSCELISLKDWLDSISYSA-LVGDVVCETPFRLHGRDLDEVSKQEL- 283
+ L+L+ N +C CE++ L D L + + S +CE P R+ GR + ++ +EL
Sbjct: 183 SMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELN 242
Query: 284 CPRRLISDYEMRPQTPLSTTG 304
C R I+ PQ T+G
Sbjct: 243 CERPRITS---EPQDADVTSG 260
Score = 86.3 bits (212), Expect = 1e-16
Identities = 68/243 (27%), Positives = 105/243 (43%), Gaps = 42/243 (17%)
Query: 374 CPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLEAT 433
CP+ C C V C +E++ + P+ + L N I ++ F
Sbjct: 36 CPSRCLC------FRTTVRCMHLLLEAVPAVAPQT---SILDLRFNRIREIQPGAFRRLR 86
Query: 434 GLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLI 493
L+ L L NN+I I AF DL NL+ LYL N I+ + + F GL SL+ L+L +N I
Sbjct: 87 NLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQI 146
Query: 494 REIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLRLNLRSNHFTSLPVSGVLDQLK 553
+ +F +P L+ LFL+NN + + G F NH L+
Sbjct: 147 ETLDPDSFQHLPKLERLFLHNNRITHLVPGTF------------NH------------LE 182
Query: 554 SLIQIDLHDNPWDCTCDIVGMKLWVEQL-----KVGVLVDEVICKAPKKFAETDMRSIKS 608
S+ ++ L N C C+I LW+ L + G IC+ P++ + +I
Sbjct: 183 SMKRLRLDSNTLHCDCEI----LWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITP 238
Query: 609 ELL 611
E L
Sbjct: 239 EEL 241
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 99.8 bits (247), Expect = 1e-20
Identities = 67/213 (31%), Positives = 111/213 (52%), Gaps = 28/213 (13%)
Query: 88 LSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDD 147
LS N + R+ + F + + L+LGSN + + + AF L+ LRRL L++N +E ++
Sbjct: 187 LSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPF 246
Query: 148 TFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVP-LTHLD 206
F GL NLEYL + + I + + F ++ L+ LIL+ N L +L ++ F + L +L
Sbjct: 247 AFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLK 306
Query: 207 LRGNR---------------LKLLP---------YVGLLQHMDKVVELQLEENPWNCSCE 242
L NR LK+L + +L+ + ++ LQ NPW C+C+
Sbjct: 307 LDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCK 366
Query: 243 LISLKDWLDSISYSALVGDVVCETPFRLHGRDL 275
L+ L+DWL S SA+ ++ C+ P + GR L
Sbjct: 367 LLGLRDWLAS---SAITLNIYCQNPPSMRGRAL 396
Score = 96.3 bits (238), Expect = 1e-19
Identities = 66/217 (30%), Positives = 102/217 (47%), Gaps = 30/217 (13%)
Query: 416 LTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPE 475
L+ N I + + F L L+LG+N ++ + AF L +LRRL L+ N IE + P
Sbjct: 187 LSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPF 246
Query: 476 LFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFS--------- 526
F GL +L+YL L+ + IR + F + NL+ L L++N L+ + S FS
Sbjct: 247 AFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLK 306
Query: 527 -----------------GLTLLRLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTC 569
G +L LNL N+ T+L VL L SLI + + NPW+C C
Sbjct: 307 LDRNRIISIDNDTFENMGASLKILNLSFNNLTALH-PRVLKPLSSLIHLQANSNPWECNC 365
Query: 570 DIVGMKLWVEQLKVGVLVDEVICKAPKKFAETDMRSI 606
++G++ W L + + C+ P +R I
Sbjct: 366 KLLGLRDW---LASSAITLNIYCQNPPSMRGRALRYI 399
Score = 92.0 bits (227), Expect = 2e-18
Identities = 67/212 (31%), Positives = 103/212 (48%), Gaps = 29/212 (13%)
Query: 378 CSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLEATGLDL 437
CS Q+ G +NC+ + SI + P+ + +YLT N I+ + ++ L
Sbjct: 32 CSSVCQLCT-GRQINCRNLGLSSIPKNFPE--STVFLYLTGNNISYINESELTGLHSLVA 88
Query: 438 LHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIREIQ 497
L+L N+ I + +AF L +L L+LN N I+RL P +F GL +L+ L+LQYN + +
Sbjct: 89 LYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVP 148
Query: 498 SGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLR------------------------- 532
G F+ + ++Q L L N L + SG F G+ LR
Sbjct: 149 RGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLAC 208
Query: 533 LNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNP 564
L L SN+ T +P S + LKSL ++ L NP
Sbjct: 209 LYLGSNNLTKVP-SNAFEVLKSLRRLSLSHNP 239
Score = 62.8 bits (151), Expect = 2e-09
Identities = 41/134 (30%), Positives = 64/134 (47%), Gaps = 1/134 (0%)
Query: 83 IYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLE 142
+Y L L+ N + RL P F L+L N + + G F+ L ++ L+L N+L
Sbjct: 110 LYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLT 169
Query: 143 LLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFV-P 201
+L TF+G+ L L + N I I + F L L L L N L+ +P+N F +
Sbjct: 170 VLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKS 229
Query: 202 LTHLDLRGNRLKLL 215
L L L N ++ +
Sbjct: 230 LRRLSLSHNPIEAI 243
Score = 59.3 bits (142), Expect = 2e-08
Identities = 57/231 (24%), Positives = 100/231 (43%), Gaps = 33/231 (14%)
Query: 33 LVLSCAETIDYYGEICDNACPCEEKDGILTVSCENRGIISLSEISPPRFP--IYHLLLSG 90
LV++C + + EI + C+ G ++C N G+ S+ P FP L L+G
Sbjct: 15 LVVTCYLLLLLHKEILGCSSVCQLCTG-RQINCRNLGLSSI----PKNFPESTVFLYLTG 69
Query: 91 NLLNRL------------------------YPNEFVNYTGASILHLGSNVIQDIETGAFH 126
N ++ + YP FV L L +N I+ ++ G F
Sbjct: 70 NNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFK 129
Query: 127 GLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILND 186
GL LR L+L N++ + F L +++YL + N ++V+ F + L++L L++
Sbjct: 130 GLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSN 189
Query: 187 NLLSSLPNNLFRFVP-LTHLDLRGNRLKLLPYVGLLQHMDKVVELQLEENP 236
N + + + F+ + L L L N L +P + + + L L NP
Sbjct: 190 NNILRISESGFQHLENLACLYLGSNNLTKVP-SNAFEVLKSLRRLSLSHNP 239
>gi|38202222 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 99.4 bits (246), Expect = 1e-20
Identities = 67/215 (31%), Positives = 117/215 (54%), Gaps = 11/215 (5%)
Query: 435 LDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIER--LSPELFYGLQSLQYLFLQYNL 492
++ L L +NRIS I + LT+L+RL L+GN + L ++F+ L +L L L N
Sbjct: 177 IEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNS 236
Query: 493 IREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLT-LLRLNLRSNHFTSLPVSGVLDQ 551
+ P NL+ L+L +N + +P FS L L RL++ +N+ ++LP G+ D
Sbjct: 237 LTAAPVNL--PGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLP-QGIFDD 293
Query: 552 LKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPKKFAETDMRSIKSELL 611
L ++ Q+ L +NPW C C + ++ W++ L V V V ++C+AP+K ++ + +EL
Sbjct: 294 LDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELF 353
Query: 612 -CPD---YSDVVVSTPTPSSIQVPARTSAVTPAVR 642
C D S + ++T P+++ PA+ P +
Sbjct: 354 DCKDSGIVSTIQITTAIPNTV-YPAQGQWPAPVTK 387
Score = 87.0 bits (214), Expect = 7e-17
Identities = 68/245 (27%), Positives = 112/245 (45%), Gaps = 19/245 (7%)
Query: 110 LHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLEL--LRDDTFLGLENLEYLQVDYNYISV 167
L L N I I + + GL L+RL L+ N L L D F L NL L + N ++
Sbjct: 180 LRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTA 239
Query: 168 IEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFV-PLTHLDLRGNRLKLLPYVGLLQHMDK 226
N G L+ L L DN ++ +P N F ++ L LD+ N L LP G+ +D
Sbjct: 240 APVNLPGTN--LRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQ-GIFDDLDN 296
Query: 227 VVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPR 286
+ +L L NPW C C++ ++DWL S+ V ++C+ P ++ G + +++ +
Sbjct: 297 ITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAEL---- 352
Query: 287 RLISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPTS 346
++ + +ST + T A N+V + P K P + P + T+
Sbjct: 353 -----FDCKDSGIVST---IQITTAIPNTVYPAQGQWPAPVTKQP-DIKNPKLTKDHQTT 403
Query: 347 RQPSK 351
PS+
Sbjct: 404 GSPSR 408
Score = 41.6 bits (96), Expect = 0.004
Identities = 50/190 (26%), Positives = 80/190 (42%), Gaps = 22/190 (11%)
Query: 374 CPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVR-RTDFLEA 432
CP+ C C D G + C +R + SI P+ + +YL N I +D
Sbjct: 31 CPSVCRC-----DAGF-IYCNDRFLTSIPTGIPE--DATTLYLQNNQINNAGIPSDLKNL 82
Query: 433 TGLDLLHLGNNRISMIQDRAFGDLTNL----RRLYLNGNRIERLSPELFYGLQSLQYLFL 488
++ ++L +N + TNL + L+L N I ++ + + L+ L L
Sbjct: 83 LKVERIYLYHNSLDEFP-------TNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHL 135
Query: 489 QYNLIR--EIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLRLNLRSNHFTSLPVS 546
N + I+ G F L+LLFL+ N L +P G+ + LRL+ S P
Sbjct: 136 DDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSL 195
Query: 547 GVLDQLKSLI 556
L LK L+
Sbjct: 196 QGLTSLKRLV 205
Score = 36.2 bits (82), Expect = 0.15
Identities = 32/121 (26%), Positives = 54/121 (44%), Gaps = 2/121 (1%)
Query: 410 NPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRI 469
N +K+YL +N+I V F L L + NN +S + F DL N+ +L L N
Sbjct: 248 NLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNP- 306
Query: 470 ERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLT 529
++ + LQ L ++ N +R + + V + + LN L SG+ S +
Sbjct: 307 WYCGCKMKWVRDWLQSLPVKVN-VRGLMCQAPEKVRGMAIKDLNAELFDCKDSGIVSTIQ 365
Query: 530 L 530
+
Sbjct: 366 I 366
Score = 32.7 bits (73), Expect = 1.7
Identities = 22/85 (25%), Positives = 40/85 (47%), Gaps = 6/85 (7%)
Query: 68 RGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHG 127
R ++ + ++ P + L L N +NR+ PN F L + +N + ++ G F
Sbjct: 234 RNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDD 293
Query: 128 LRGLRRLHLNNN------KLELLRD 146
L + +L L NN K++ +RD
Sbjct: 294 LDNITQLILRNNPWYCGCKMKWVRD 318
>gi|7019383 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 99.4 bits (246), Expect = 1e-20
Identities = 67/215 (31%), Positives = 117/215 (54%), Gaps = 11/215 (5%)
Query: 435 LDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIER--LSPELFYGLQSLQYLFLQYNL 492
++ L L +NRIS I + LT+L+RL L+GN + L ++F+ L +L L L N
Sbjct: 177 IEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNS 236
Query: 493 IREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLT-LLRLNLRSNHFTSLPVSGVLDQ 551
+ P NL+ L+L +N + +P FS L L RL++ +N+ ++LP G+ D
Sbjct: 237 LTAAPVNL--PGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLP-QGIFDD 293
Query: 552 LKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPKKFAETDMRSIKSELL 611
L ++ Q+ L +NPW C C + ++ W++ L V V V ++C+AP+K ++ + +EL
Sbjct: 294 LDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELF 353
Query: 612 -CPD---YSDVVVSTPTPSSIQVPARTSAVTPAVR 642
C D S + ++T P+++ PA+ P +
Sbjct: 354 DCKDSGIVSTIQITTAIPNTV-YPAQGQWPAPVTK 387
Score = 87.0 bits (214), Expect = 7e-17
Identities = 68/245 (27%), Positives = 112/245 (45%), Gaps = 19/245 (7%)
Query: 110 LHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLEL--LRDDTFLGLENLEYLQVDYNYISV 167
L L N I I + + GL L+RL L+ N L L D F L NL L + N ++
Sbjct: 180 LRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTA 239
Query: 168 IEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFV-PLTHLDLRGNRLKLLPYVGLLQHMDK 226
N G L+ L L DN ++ +P N F ++ L LD+ N L LP G+ +D
Sbjct: 240 APVNLPGTN--LRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQ-GIFDDLDN 296
Query: 227 VVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPR 286
+ +L L NPW C C++ ++DWL S+ V ++C+ P ++ G + +++ +
Sbjct: 297 ITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAEL---- 352
Query: 287 RLISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPNKPRVRPTS 346
++ + +ST + T A N+V + P K P + P + T+
Sbjct: 353 -----FDCKDSGIVST---IQITTAIPNTVYPAQGQWPAPVTKQP-DIKNPKLTKDHQTT 403
Query: 347 RQPSK 351
PS+
Sbjct: 404 GSPSR 408
Score = 41.6 bits (96), Expect = 0.004
Identities = 50/190 (26%), Positives = 80/190 (42%), Gaps = 22/190 (11%)
Query: 374 CPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVR-RTDFLEA 432
CP+ C C D G + C +R + SI P+ + +YL N I +D
Sbjct: 31 CPSVCRC-----DAGF-IYCNDRFLTSIPTGIPE--DATTLYLQNNQINNAGIPSDLKNL 82
Query: 433 TGLDLLHLGNNRISMIQDRAFGDLTNL----RRLYLNGNRIERLSPELFYGLQSLQYLFL 488
++ ++L +N + TNL + L+L N I ++ + + L+ L L
Sbjct: 83 LKVERIYLYHNSLDEFP-------TNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHL 135
Query: 489 QYNLIR--EIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLRLNLRSNHFTSLPVS 546
N + I+ G F L+LLFL+ N L +P G+ + LRL+ S P
Sbjct: 136 DDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSL 195
Query: 547 GVLDQLKSLI 556
L LK L+
Sbjct: 196 QGLTSLKRLV 205
Score = 36.2 bits (82), Expect = 0.15
Identities = 32/121 (26%), Positives = 54/121 (44%), Gaps = 2/121 (1%)
Query: 410 NPKKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRI 469
N +K+YL +N+I V F L L + NN +S + F DL N+ +L L N
Sbjct: 248 NLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNP- 306
Query: 470 ERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLT 529
++ + LQ L ++ N +R + + V + + LN L SG+ S +
Sbjct: 307 WYCGCKMKWVRDWLQSLPVKVN-VRGLMCQAPEKVRGMAIKDLNAELFDCKDSGIVSTIQ 365
Query: 530 L 530
+
Sbjct: 366 I 366
Score = 32.7 bits (73), Expect = 1.7
Identities = 22/85 (25%), Positives = 40/85 (47%), Gaps = 6/85 (7%)
Query: 68 RGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHG 127
R ++ + ++ P + L L N +NR+ PN F L + +N + ++ G F
Sbjct: 234 RNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDD 293
Query: 128 LRGLRRLHLNNN------KLELLRD 146
L + +L L NN K++ +RD
Sbjct: 294 LDNITQLILRNNPWYCGCKMKWVRD 318
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 99.4 bits (246), Expect = 1e-20
Identities = 67/216 (31%), Positives = 105/216 (48%), Gaps = 17/216 (7%)
Query: 374 CPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLEAT 433
CP C+C + V+C R + SI + P N +++ L N + + TDF T
Sbjct: 29 CPRRCACYMPTE-----VHCTFRYLTSIPDSIPP--NVERINLGYNSLVRLMETDFSGLT 81
Query: 434 GLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLI 493
L+LL L +N I I D+ F DL L+ L ++ N++ +L + FYGL+SL L + +N I
Sbjct: 82 KLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRSLTRLHMDHNNI 141
Query: 494 REIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLR---------LNLRSNHFTSLP 544
I F + L+L+ L N L + F L+ L+ L L N TSLP
Sbjct: 142 EFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFLYLSDNFLTSLP 201
Query: 545 VSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQ 580
++ + L + LH NPW C C + + W+++
Sbjct: 202 -QEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQE 236
Score = 94.7 bits (234), Expect = 4e-19
Identities = 74/234 (31%), Positives = 108/234 (46%), Gaps = 21/234 (8%)
Query: 26 LAFAVTSLVLSCAETIDYYGEICDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYH 85
++FAV LV + G+ C C C V C R + S+ + PP +
Sbjct: 13 VSFAVICLVATPG------GKACPRRCACYMPT---EVHCTFRYLTSIPDSIPPN--VER 61
Query: 86 LLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLR 145
+ L N L RL +F T +L L SN I I F L+ L+ L ++ NK+ L+
Sbjct: 62 INLGYNSLVRLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQ 121
Query: 146 DDTFLGLENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLLSSL-PN--------NL 196
DTF GL +L L +D+N I I P F L+ L+++ L N L+ L P+ +
Sbjct: 122 KDTFYGLRSLTRLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQI 181
Query: 197 FRFVPLTHLDLRGNRLKLLPYVGLLQHMDKVVELQLEENPWNCSCELISLKDWL 250
F+ + L L N L LP ++ +M + L L NPW C C L L DW+
Sbjct: 182 FKISFIKFLYLSDNFLTSLPQ-EMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWI 234
>gi|34577057 fibronectin leucine rich transmembrane protein 1 [Homo
sapiens]
Length = 674
Score = 97.4 bits (241), Expect = 6e-20
Identities = 81/274 (29%), Positives = 136/274 (49%), Gaps = 22/274 (8%)
Query: 412 KKMYLTENYIAVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRI-- 469
K ++L+ N+++ + L T L+ L L +NRIS I AF L +LRRL L+GN +
Sbjct: 180 KLLFLSRNHLSSI--PSGLPHT-LEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLAN 236
Query: 470 ERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLT 529
+R++ + F LQ+L L L N + P +LQ L+L +N + +P + +
Sbjct: 237 QRIADDTFSRLQNLTELSLVRNSLAAPPLNL--PSAHLQKLYLQDNAISHIPYNTLAKMR 294
Query: 530 LL-RLNLRSNHFTSLPVSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVGVLVD 588
L RL+L +N+ T+LP G+ D L +L Q+ L +NPW C C+++ ++ WV+ V V
Sbjct: 295 ELERLDLSNNNLTTLP-RGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVKARAAVVNVR 353
Query: 589 EVICKAPKKFAETDMRSIKSEL-----LCPDYSDVVVSTPTPSSIQVPART--------S 635
++C+ P+K ++ I SE+ P + T +S A T
Sbjct: 354 GLMCQGPEKVRGMAIKDITSEMDECFETGPQGGVANAAAKTTASNHASATTPQGSLFTLK 413
Query: 636 AVTPAVRLNSTGAPASLGAGGGASSVPLSVLILS 669
A P +RL + + G GA ++ + V L+
Sbjct: 414 AKRPGLRLPDSNIDYPMATGDGAKTLAIHVKALT 447
Score = 95.9 bits (237), Expect = 2e-19
Identities = 76/233 (32%), Positives = 113/233 (48%), Gaps = 16/233 (6%)
Query: 110 LHLGSNVIQDIETGAFHGLRGLRRLHLNNNKL--ELLRDDTFLGLENLEYLQVDYNYISV 167
L L N I I AF GL LRRL L+ N L + + DDTF L+NL L + N ++
Sbjct: 203 LRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAA 262
Query: 168 IEPNAFGKLHLLQVLILNDNLLSSLP-NNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMDK 226
P HL Q L L DN +S +P N L + L LDL N L LP GL +
Sbjct: 263 -PPLNLPSAHL-QKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPR-GLFDDLGN 319
Query: 227 VVELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEV-SKQELCP 285
+ +L L NPW C C L+ L+DW+ + + V ++C+ P ++ G + ++ S+ + C
Sbjct: 320 LAQLLLRNNPWFCGCNLMWLRDWVKARAAVVNVRGLMCQGPEKVRGMAIKDITSEMDEC- 378
Query: 286 RRLISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKPPKGTRQPN 338
+E PQ ++ TT ++ S T +++ K P G R P+
Sbjct: 379 ------FETGPQGGVANAA-AKTTASNHASATTPQGSLFTLKAKRP-GLRLPD 423
Score = 48.5 bits (114), Expect = 3e-05
Identities = 57/221 (25%), Positives = 98/221 (44%), Gaps = 21/221 (9%)
Query: 342 VRPTSRQPSKDLGYSNYGPSIAYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESI 401
V T+ +D + YG IA+ T+ CP+ C C D G + C +R + SI
Sbjct: 23 VMTTATMDLRDWLFLCYG-LIAFLTEVIDSTTCPSVCRC-----DNGF-IYCNDRGLTSI 75
Query: 402 -AELQPKPYNPKKMYLTENYIAVVR-RTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNL 459
A++ P + +YL N I D + +++L N + + +L
Sbjct: 76 PADI---PDDATTLYLQNNQINNAGIPQDLKTKVNVQVIYLYENDLD---EFPINLPRSL 129
Query: 460 RRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIR--EIQSGTFDPVPNLQLLFLNNNLL 517
R L+L N + ++ + + L+ L L N + I+ F L+LLFL+ N L
Sbjct: 130 RELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHL 189
Query: 518 QAMPSGVFSGLTLLRLNLRSNHFTSLPVSGV--LDQLKSLI 556
++PSG+ TL L L N +++P+ L+ L+ L+
Sbjct: 190 SSIPSGL--PHTLEELRLDDNRISTIPLHAFKGLNSLRRLV 228
>gi|10190722 leucine-rich repeats and transmembrane domains 1 [Homo
sapiens]
Length = 345
Score = 96.3 bits (238), Expect = 1e-19
Identities = 76/272 (27%), Positives = 118/272 (43%), Gaps = 33/272 (12%)
Query: 48 CDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYHLLLSGNLLNRLYPNEFVNYTGA 107
C + C C+ V C +G+ + PP+
Sbjct: 21 CPDKCYCQSSTNF--VDCSQQGLAEIPSHLPPQ--------------------------T 52
Query: 108 SILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISV 167
LHL N I + AF + L L+L+NN L L F GL++L+ L + N +
Sbjct: 53 RTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLS 112
Query: 168 IEPNAFGKLHLLQVLILNDNLLSSLPNNLFR-FVPLTHLDLRGNRLKLLPYVGLLQHMDK 226
+E F L L+ L L+ N +S LP +L + LT L ++ N+L+ L LL+ M
Sbjct: 113 LESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLDR-ALLESMPS 171
Query: 227 VVELQLEENPWNCSCELISLKDWLDSISY-SALVGDVVCETPFRLHGRDLDEVSKQ--EL 283
V L L++N W C+C L+ LK WL+ Y L ++CE+P G+DL + + +
Sbjct: 172 VRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHELYQP 231
Query: 284 CPRRLISDYEMRPQTPLSTTGYLHTTPASVNS 315
CP + Q P S G + P + N+
Sbjct: 232 CPLPAPDPVSSQAQWPGSAHGVVLRPPENHNA 263
Score = 93.6 bits (231), Expect = 8e-19
Identities = 63/196 (32%), Positives = 103/196 (52%), Gaps = 11/196 (5%)
Query: 438 LHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIREIQ 497
LHL +N+I + AF + L L L+ N + L+P F+GLQ LQ L L N + ++
Sbjct: 55 LHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLE 114
Query: 498 SGTFDPVPNLQLLFLNNNLLQAMPSGV---FSGLTLLRLNLRSNHFTSLPVSGVLDQLKS 554
S F +P L+ L L++N + +P+ + + LT+L ++ N L +L+ + S
Sbjct: 115 SRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILA--VQQNQLQQLD-RALLESMPS 171
Query: 555 LIQIDLHDNPWDCTCDIVGMKLWVEQ-LKVGVLVDEVICKAPKKFAETDMRSIKSELLCP 613
+ + L DN W C C ++G+KLW+E+ + G L D +IC++P + D+ I EL
Sbjct: 172 VRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESPDTWKGKDLLRIPHEL--- 228
Query: 614 DYSDVVVSTPTPSSIQ 629
Y + P P S Q
Sbjct: 229 -YQPCPLPAPDPVSSQ 243
>gi|31542244 leucine rich repeat and fibronectin type III domain
containing 5 [Homo sapiens]
Length = 719
Score = 94.4 bits (233), Expect = 5e-19
Identities = 83/290 (28%), Positives = 126/290 (43%), Gaps = 50/290 (17%)
Query: 46 EICDNACPCEEKDGILTVSCENRGIISLSEISPPRFP--IYHLLLSGNLLNRLYPNEFVN 103
+IC C C+ L C +G++ + PP L L+ N + + +F N
Sbjct: 18 QICPKRCVCQILSPNLATLCAKKGLLFV----PPNIDRRTVELRLADNFVTNIKRKDFAN 73
Query: 104 YTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYN 163
T L L N I I AF LR LR LHLN+N+L + +D F GL NL +L ++ N
Sbjct: 74 MTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNN 133
Query: 164 YISVIEPNAFGKLHLLQVLILNDNLLSSLP----------------NNLFRFVP------ 201
+++I AF + L+ L L+ N L ++P +N+ +P
Sbjct: 134 QLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSH 193
Query: 202 ---LTHLDLRGNRLKLLPYVGLLQHMD----------KVVELQLEENPWNCSCELISLKD 248
+T LD+ N+L+ LP L Q L NP +C+CEL+
Sbjct: 194 LHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELL---- 249
Query: 249 WLDSISYSALVGDVVCETPFRLHGRDLDEVSKQE-LCPRRLIS--DYEMR 295
WL +S + C +P L GR + ++E LC LI+ +EMR
Sbjct: 250 WLRRLSREDDL--ETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMR 297
Score = 91.3 bits (225), Expect = 4e-18
Identities = 70/245 (28%), Positives = 108/245 (44%), Gaps = 47/245 (19%)
Query: 374 CPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLEAT 433
CP C C QI L C ++ + + + ++ L +N++ ++R DF T
Sbjct: 20 CPKRCVC--QILSPNLATLCAKKGLLFVPPNIDR--RTVELRLADNFVTNIKRKDFANMT 75
Query: 434 GLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLI 493
L L L N IS I AF DL NLR L+LN NR+ +++ ++F GL +L +L L N +
Sbjct: 76 SLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQL 135
Query: 494 REIQSGTFDPV------------------------PNLQLLFLNNNLLQAMPSGVFSGL- 528
I S FD V +L L L++N++ +P G FS L
Sbjct: 136 TLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLH 195
Query: 529 TLLRLNLRSNHFTSLP------------VSGVLDQLKSLIQIDLHDNPWDCTCDIVGMKL 576
+ RL++ SN LP SG++ S + NP C C++ L
Sbjct: 196 KMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIIS--PSTFALSFGGNPLHCNCEL----L 249
Query: 577 WVEQL 581
W+ +L
Sbjct: 250 WLRRL 254
>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
Length = 473
Score = 94.0 bits (232), Expect = 6e-19
Identities = 78/248 (31%), Positives = 110/248 (44%), Gaps = 10/248 (4%)
Query: 110 LHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISVIE 169
LHL +Q++ G F GL L+ L+L +N L+ L DDTF L NL +L + N IS +
Sbjct: 135 LHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVP 194
Query: 170 PNAFGKLHLLQVLILNDNLLSSLPNNLFRFV-PLTHLDLRGNRLKLLPYVGLLQHMDKVV 228
AF LH L L+L+ N ++ + + FR + L L L N L LP L + +
Sbjct: 195 ERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALP-TEALAPLRALQ 253
Query: 229 ELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVSKQELCPRRL 288
L+L +NPW C C L WL S+ +V C P RL GRDL ++ +L +
Sbjct: 254 YLRLNDNPWVCDCRARPLWAWLQKFRGSS--SEVPCSLPQRLAGRDLKRLAANDLQGCAV 311
Query: 289 ISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPLKP--PKGTRQPNKPRVRPTS 346
+ P P+ T P + +A L+P P K RV P
Sbjct: 312 ATG----PYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGD 367
Query: 347 RQPSKDLG 354
P G
Sbjct: 368 SPPGNGSG 375
Score = 90.9 bits (224), Expect = 5e-18
Identities = 75/294 (25%), Positives = 129/294 (43%), Gaps = 62/294 (21%)
Query: 363 AYQTKSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIA 422
A+Q +P CP AC C ++ + +C ++ ++++ P ++++L N I+
Sbjct: 20 AWQVAAP----CPGACVC---YNEPKVTTSCPQQGLQAVPVGIPAA--SQRIFLHGNRIS 70
Query: 423 VVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNR-------------- 468
V F L +L L +N ++ I AF L L +L L+ N
Sbjct: 71 HVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLG 130
Query: 469 -----------IERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNLL 517
++ L P LF GL +LQYL+LQ N ++ + TF + NL LFL+ N +
Sbjct: 131 RLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRI 190
Query: 518 QAMPSGVFSGL-------------------------TLLRLNLRSNHFTSLPVSGVLDQL 552
++P F GL L+ L L +N+ ++LP L L
Sbjct: 191 SSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTE-ALAPL 249
Query: 553 KSLIQIDLHDNPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPKKFAETDMRSI 606
++L + L+DNPW C C + W+++ + EV C P++ A D++ +
Sbjct: 250 RALQYLRLNDNPWVCDCRARPLWAWLQKFRGS--SSEVPCSLPQRLAGRDLKRL 301
>gi|13375646 leucine rich repeat and fibronectin type III domain
containing 3 [Homo sapiens]
Length = 628
Score = 92.8 bits (229), Expect = 1e-18
Identities = 71/245 (28%), Positives = 109/245 (44%), Gaps = 40/245 (16%)
Query: 367 KSPVPLECPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRR 426
+S P CP C C Q L L+V C + + + ++ L +N+IA VRR
Sbjct: 21 QSATPSPCPRRCRCQTQ--SLPLSVLCPGAGLLFVPPSLDR--RAAELRLADNFIASVRR 76
Query: 427 TDFLEATGLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYL 486
D TGL L L N I + AF DL LR L+L+GNR+ L GL +L++L
Sbjct: 77 RDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHL 136
Query: 487 FLQYNLIREIQSGTFDP-------------------------VPNLQLLFLNNNLLQAMP 521
L N + + +G D + N+ L L++NLL ++P
Sbjct: 137 ILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVP 196
Query: 522 SGVFSGL-TLLRLNLRSNHFTSLPVSGVLDQL----------KSLIQIDLHDNPWDCTCD 570
+G FS L L RL++ SN T++P + +L S + + NP C C+
Sbjct: 197 AGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCE 256
Query: 571 IVGMK 575
+V ++
Sbjct: 257 LVWLR 261
Score = 85.5 bits (210), Expect = 2e-16
Identities = 78/274 (28%), Positives = 113/274 (41%), Gaps = 50/274 (18%)
Query: 48 CDNACPCEEKDGILTVSCENRGIISLSEISPPRFP--IYHLLLSGNLLNRLYPNEFVNYT 105
C C C+ + L+V C G++ + PP L L+ N + + + N T
Sbjct: 28 CPRRCRCQTQSLPLSVLCPGAGLLFV----PPSLDRRAAELRLADNFIASVRRRDLANMT 83
Query: 106 GASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGL------------- 152
G L L N I+ + GAF LR LR LHL+ N+L L + GL
Sbjct: 84 GLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQL 143
Query: 153 ------------ENLEYLQVDYNYISVIEPNAFGKLHLLQVLILNDNLLSSLPNNLF-RF 199
E LE L + YN + + A G+L + L L+ NLL+S+P F R
Sbjct: 144 AALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRL 203
Query: 200 VPLTHLDLRGNRLKLLPYVGLLQHMD----------KVVELQLEENPWNCSCELISLKDW 249
L LD+ NRL +P L + + L NP +C+CEL+ W
Sbjct: 204 HKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELV----W 259
Query: 250 LDSISYSALVGDV-VCETPFRLHGRDLDEVSKQE 282
L + A D+ C +P L GR V ++E
Sbjct: 260 LRRL---AREDDLEACASPPALGGRYFWAVGEEE 290
>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
sapiens]
Length = 370
Score = 89.7 bits (221), Expect = 1e-17
Identities = 66/259 (25%), Positives = 110/259 (42%), Gaps = 33/259 (12%)
Query: 374 CPTACSCNLQISDLGLNVNCQERKIESIAELQPKPYNPKKMYLTENYIAVVRRTDFLEAT 433
CP +C C+ + L V+C + ++ P + + L N ++ + F +
Sbjct: 39 CPFSCKCDSR----SLEVDCSGLGLTTVPP--DVPAATRTLLLLNNKLSALPSWAFANLS 92
Query: 434 GLDLLHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLI 493
L L L NN + + FGDLTNL L L N I L +L L++L L N +
Sbjct: 93 SLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGL 152
Query: 494 REIQSGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLRLNLRSNHFTSLPVSGVLDQLK 553
++ G FD + L+ L L +N LQ + F L L+L
Sbjct: 153 AQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQL-------------------- 192
Query: 554 SLIQIDLHDNPWDCTCDIVGMKLWVEQLKV-GVLVDEVICKAPKKFAETDMRSIKSELLC 612
+ + DNPW+C C++ K W+E G +D++ C PK+ DMR + E+
Sbjct: 193 ----LQVGDNPWECDCNLREFKHWMEWFSYRGGRLDQLACTLPKELRGKDMRMVPMEMF- 247
Query: 613 PDYSDVVVSTPTPSSIQVP 631
+Y + + + + +P
Sbjct: 248 -NYCSQLEDENSSAGLDIP 265
Score = 84.7 bits (208), Expect = 4e-16
Identities = 81/304 (26%), Positives = 119/304 (39%), Gaps = 44/304 (14%)
Query: 48 CDNACPCEEKDGILTVSCENRGIISLSEISPPRFPIYH--LLLSGNLLNRLYPNEFVNYT 105
C +C C+ + L V C G+ ++ PP P LLL N L+ L F N +
Sbjct: 39 CPFSCKCDSRS--LEVDCSGLGLTTV----PPDVPAATRTLLLLNNKLSALPSWAFANLS 92
Query: 106 GASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYI 165
L L +N + + F L L L L NN + L D L +L + N +
Sbjct: 93 SLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGL 152
Query: 166 SVIEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMD 225
+ + P F L L+ L L N L +L + F PL +L L
Sbjct: 153 AQLPPGLFDGLLALRSLSLRSNRLQNL--DRLTFEPLANLQL------------------ 192
Query: 226 KVVELQLEENPWNCSCELISLKDWLDSISY-SALVGDVVCETPFRLHGRDLDEVSKQELC 284
LQ+ +NPW C C L K W++ SY + + C P L G+D+ V +
Sbjct: 193 ----LQVGDNPWECDCNLREFKHWMEWFSYRGGRLDQLACTLPKELRGKDMRMVPME--- 245
Query: 285 PRRLISDYEMRPQTPLSTTGYLHTTPASVNSVATSSSAVYKPPL--KPPKGTRQPNKPRV 342
+ +Y + + S+ G P + A+ A KP +P T P K R
Sbjct: 246 ----MFNYCSQLEDENSSAGL--DIPGPPCTKASPEPAKPKPGAEPEPEPSTACPQKQRH 299
Query: 343 RPTS 346
RP S
Sbjct: 300 RPAS 303
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,249,736
Number of Sequences: 37866
Number of extensions: 2282240
Number of successful extensions: 22257
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 365
Number of HSP's successfully gapped in prelim test: 220
Number of HSP's that attempted gapping in prelim test: 14625
Number of HSP's gapped (non-prelim): 4602
length of query: 958
length of database: 18,247,518
effective HSP length: 112
effective length of query: 846
effective length of database: 14,006,526
effective search space: 11849520996
effective search space used: 11849520996
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.