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Search of human proteins with 38570058
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38570058 hypothetical protein LOC80129 [Homo sapiens]
(715 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38570058 hypothetical protein LOC80129 [Homo sapiens] 1364 0.0
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 116 6e-26
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 112 1e-24
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 112 1e-24
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 112 1e-24
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 112 1e-24
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 110 3e-24
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 105 2e-22
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 105 2e-22
gi|56961680 coiled-coil domain containing 147 [Homo sapiens] 105 2e-22
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 104 3e-22
gi|34577114 cytomatrix protein p110 [Homo sapiens] 103 6e-22
gi|156104908 myosin heavy chain 6 [Homo sapiens] 102 1e-21
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 101 2e-21
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 101 3e-21
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 101 3e-21
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 101 3e-21
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 100 4e-21
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 100 4e-21
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 100 5e-21
gi|38044112 restin isoform b [Homo sapiens] 100 6e-21
gi|4506751 restin isoform a [Homo sapiens] 100 6e-21
gi|31982906 cingulin-like 1 [Homo sapiens] 100 6e-21
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 99 2e-20
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 99 2e-20
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 99 2e-20
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 99 2e-20
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 99 2e-20
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 99 2e-20
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 99 2e-20
>gi|38570058 hypothetical protein LOC80129 [Homo sapiens]
Length = 715
Score = 1364 bits (3531), Expect = 0.0
Identities = 715/715 (100%), Positives = 715/715 (100%)
Query: 1 MSLDCTSHIALGAASPAPEETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQ 60
MSLDCTSHIALGAASPAPEETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQ
Sbjct: 1 MSLDCTSHIALGAASPAPEETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQ 60
Query: 61 SELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKI 120
SELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKI
Sbjct: 61 SELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKI 120
Query: 121 RTEITAHAAIKENQELKKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLD 180
RTEITAHAAIKENQELKKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLD
Sbjct: 121 RTEITAHAAIKENQELKKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLD 180
Query: 181 PDERNDKASDEDLILKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVN 240
PDERNDKASDEDLILKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVN
Sbjct: 181 PDERNDKASDEDLILKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVN 240
Query: 241 REQKKAASCTEEKEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKK 300
REQKKAASCTEEKEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKK
Sbjct: 241 REQKKAASCTEEKEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKK 300
Query: 301 SSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREE 360
SSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREE
Sbjct: 301 SSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREE 360
Query: 361 SRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGV 420
SRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGV
Sbjct: 361 SRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGV 420
Query: 421 LRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENK 480
LRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENK
Sbjct: 421 LRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENK 480
Query: 481 TIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQK 540
TIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQK
Sbjct: 481 TIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQK 540
Query: 541 KVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKK 600
KVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKK
Sbjct: 541 KVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKK 600
Query: 601 LMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREVVSQM 660
LMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREVVSQM
Sbjct: 601 LMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREVVSQM 660
Query: 661 LGLNVTSLALPDYEIIKCLERLVHSHQHHFVTCACLKDVTTGQERHPQGHLQLLH 715
LGLNVTSLALPDYEIIKCLERLVHSHQHHFVTCACLKDVTTGQERHPQGHLQLLH
Sbjct: 661 LGLNVTSLALPDYEIIKCLERLVHSHQHHFVTCACLKDVTTGQERHPQGHLQLLH 715
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 116 bits (291), Expect = 6e-26
Identities = 158/671 (23%), Positives = 294/671 (43%), Gaps = 79/671 (11%)
Query: 27 EVPVTREQLNHYRNVAQNARSELAATLVKFECAQSEL------QDLRSKMLSKEVSCQE- 79
+V ++L N + R+ELA + K + + D +S L+K+ S E
Sbjct: 1249 KVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALES 1308
Query: 80 -LKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKK 138
L+ E +E N +K SL T L+ ++E+E + E H K+ L
Sbjct: 1309 QLQDTQELLQEENRQKLSLSTKLK----QVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364
Query: 139 KVVELNEKLQK---CSKENEENKKQVSKNC----RKHEEFLTQLRDCLDPDERNDKASDE 191
+V ++ +K++ C + EE K+++ K+ ++HEE + D L+ + + +
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAY-DKLEKTKTRLQQELD 1423
Query: 192 DLILKLRDLR--------KENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQ 243
DL++ L R K+ +F Q++ E+TI+ E + E +E ++
Sbjct: 1424 DLLVDLDHQRQSACNLEKKQKKF--DQLLAEEKTISAKYAEERDRAE------AEAREKE 1475
Query: 244 KKAASCTEEKEKLNQDLLSAVEAKEALEREVKIFQ---ERLLA-----GQQVWDASK--- 292
KA S E+ A+E K LER K F+ E L++ G+ V + K
Sbjct: 1476 TKALSLARALEE-------AMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKR 1528
Query: 293 ---QEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTIL 349
Q+V +K ELE L+A++DA + + + + L+GR + + ++
Sbjct: 1529 ALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLV 1588
Query: 350 EKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLT 409
++REM++ E + S A +L L A + +A L LQ Q+
Sbjct: 1589 RQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMK 1648
Query: 410 HLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLV 469
EL R+ + + ++ K L S + ++ Q+ EL R R Q
Sbjct: 1649 DCMRELDDTRASREEILAQAKENEKKLK--SMEAEMIQLQEELAAAER----AKRQAQQE 1702
Query: 470 RLESNAVIENKT----IAHNLQRKLKTQ----KERLESKELHMSLLRQKIAQLE-EEKQA 520
R E I N + +A +R+L+ + +E LE ++ + L+ ++ + + Q
Sbjct: 1703 RDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQI 1762
Query: 521 RTALVVERDNAHLTIRNLQKKVERLQKELNT-CRDLHTELKAKL-ADTNELKIKTLEQTK 578
T L +ER +A N ++++ER KEL +++ +K+K A L+ K + +
Sbjct: 1763 NTDLNLERSHAQKN-ENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEE 1821
Query: 579 AIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKK 638
+++ K R K + EKKL V ++D A++ K++A + ++ +K LK+
Sbjct: 1822 QLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQA----DKASTRLKQLKR 1877
Query: 639 SLEEAEKREKQ 649
LEEAE+ ++
Sbjct: 1878 QLEEAEEEAQR 1888
Score = 112 bits (279), Expect = 2e-24
Identities = 146/683 (21%), Positives = 300/683 (43%), Gaps = 110/683 (16%)
Query: 58 CAQSELQDLRSKMLSK----EVSCQELKAEMESYKEN----NARKSSLLTSLRDRVQELE 109
CA++E +LR+++ +K E C +L+A +E +E A K + ++++ ++LE
Sbjct: 896 CAEAE--ELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953
Query: 110 EESAALSTSKIRTEITAHAAIKENQELKKKVVELNEKLQKCSK--------------ENE 155
EE +A ++ ++T A +K+ +E + + + N KL K K E E
Sbjct: 954 EEESARQKLQLE-KVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEE 1012
Query: 156 ENKKQVSKNCRKHEEFLTQLRDCLDPDERN-------------DKASDEDLILKLR---- 198
E K ++K KHE +T L + L +E+ D D I +L+
Sbjct: 1013 EKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIA 1072
Query: 199 ----DLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKE 254
L K+ E ++ + +EE M K RE ++ SE+ + + + + E
Sbjct: 1073 ELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQI-SELQEDLESERASRNKAE 1131
Query: 255 KLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKAS-- 312
K +DL E EAL+ E++ + A Q++ +QEV++LKK+ E K+ +A
Sbjct: 1132 KQKRDL---GEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ 1188
Query: 313 ---------------------------QDAVTTSQSQYFSFREKIAALLRGRLSMTGSTE 345
+ A T +++ ++ LL+G+ G +E
Sbjct: 1189 EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGK----GDSE 1244
Query: 346 DT---ILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLE 402
+ +++E+ + +R+ ++L ++++L +L +G ++ ++ K
Sbjct: 1245 HKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFS 1304
Query: 403 TLQGQLTHLEAEL-------VSGGVLRDNLNFEKQKYLKFLDQLSQ-KMKLDQMAAELGF 454
L+ QL + L +S + EK + + L++ + K L++ A L
Sbjct: 1305 ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364
Query: 455 DMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQL 514
+ D+ + + LE+ ++ K LQ+ L+ +R E K L + +L
Sbjct: 1365 QVA-DMKKKMEDSVGCLETAEEVKRK-----LQKDLEGLSQRHEEKVAAYDKLEKTKTRL 1418
Query: 515 EEEKQARTALVVERDNAHLTIRNL---QKKVERLQKELNTCRDLHTELKAKL-ADTNELK 570
++E L+V+ D+ + NL QKK ++L E T + E + + A+ E +
Sbjct: 1419 QQELDD---LLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKE 1475
Query: 571 IKTLEQTKAIEDLNKSRDQLEKMKEKAEKK---LMSVKSELDTTEHEAKENKERARNMIE 627
K L +A+E+ + + +LE++ ++ + LMS K ++ + HE +++K +E
Sbjct: 1476 TKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVE 1535
Query: 628 VVTSEMKTLKKSLEEAEKREKQL 650
+ ++++ L+ L+ E + +L
Sbjct: 1536 EMKTQLEELEDELQATEDAKLRL 1558
Score = 108 bits (269), Expect = 2e-23
Identities = 147/656 (22%), Positives = 291/656 (44%), Gaps = 84/656 (12%)
Query: 32 REQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKEN- 90
+EQL + A A K + + DL +++ +E CQ L+AE + ++N
Sbjct: 886 QEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNI 945
Query: 91 -----------NARKSSLLTSLRD--RVQELEEESAALSTSKIRTEITAHAAIKENQELK 137
+AR+ L + ++++LEEE L + KE + L+
Sbjct: 946 QELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCK-------LAKEKKLLE 998
Query: 138 KKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKL 197
++ E L E EE K ++K KHE +T L + L +E+ +
Sbjct: 999 DRIAEFTTNL----TEEEEKSKSLAKLKNKHEAMITDLEERLRREEK-----------QR 1043
Query: 198 RDLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLN 257
++L K ++G L + + E++A+ + E M+LA + Q A EE + N
Sbjct: 1044 QELEKTRRKLEGDSTDLSD--QIAELQAQIA-ELKMQLAKKEEELQAALARVEEEAAQKN 1100
Query: 258 QDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVT 317
A++ LE ++ QE L + + + ++++ L + L+ L+ + D+ T
Sbjct: 1101 M----ALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDS-T 1155
Query: 318 TSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSRE--------ESRDRMVSQL 369
+Q + S RE+ +L+ L T + ++++R+ S+ E R+ + L
Sbjct: 1156 AAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANL 1215
Query: 370 EAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEK 429
E L + G+ + + LQ +E+ + ++ QL L+ + G +R L +
Sbjct: 1216 EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKV 1275
Query: 430 QKYLKFLDQLSQKM-KLDQMAAELGFDM-RLDVVLARTEQLVRLESNAVIENKTIAHNLQ 487
K LD ++ + + D +++L D L+ L T++L++ E+ + +L
Sbjct: 1276 TKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKL-------SLS 1328
Query: 488 RKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQKKVERLQK 547
KLK ++ S QLEEE++A+ L + H + +++KK+E
Sbjct: 1329 TKLKQVEDEKNSFR----------EQLEEEEEAKHNLEKQIATLHAQVADMKKKME---- 1374
Query: 548 ELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSE 607
+ C + E+K KL + ++ L Q E+ + D+LEK K + +++L + +
Sbjct: 1375 DSVGCLETAEEVKRKL----QKDLEGLSQRH--EEKVAAYDKLEKTKTRLQQELDDLLVD 1428
Query: 608 LDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREVVSQMLGL 663
LD + ++ N E+ + + + +E KT+ S + AE+R++ A+ RE ++ L L
Sbjct: 1429 LD-HQRQSACNLEKKQKKFDQLLAEEKTI--SAKYAEERDRAEAEAREKETKALSL 1481
Score = 91.7 bits (226), Expect = 2e-18
Identities = 157/745 (21%), Positives = 311/745 (41%), Gaps = 112/745 (15%)
Query: 33 EQLNHYRNVAQNARSELAAT---LVKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKE 89
EQL + Q + E T L K E Q L+D K+ ++ ++ AE +
Sbjct: 950 EQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLT 1009
Query: 90 NNARKS-----------SLLTSLRDRVQELEEESAALSTSKIR-----TEITAHAAIKEN 133
KS +++T L +R++ E++ L ++ + T+++ A +
Sbjct: 1010 EEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQA 1069
Query: 134 Q--ELKKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDE 191
Q ELK ++ + E+LQ EE Q + +K E +Q+ + L D +++AS
Sbjct: 1070 QIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISE-LQEDLESERASRN 1128
Query: 192 DLILKLRDLRKENEFVKGQIVILEETIN--VHEMEAKASRETIMRLASEVNREQKKA--A 247
+ RDL +E E +K + LE+T++ + E ++ RE + + + E+ K A
Sbjct: 1129 KAEKQKRDLGEELEALKTE---LEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEA 1185
Query: 248 SCTEEKEKLNQDLLSAVEAKEALEREVKIFQERL---LAGQQVWDASKQEVSLLKKSSSE 304
E ++K +Q + E E +R VK E+ L ++ A++ +V L K SE
Sbjct: 1186 QIQEMRQKHSQAVEELAEQLEQTKR-VKANLEKAKQTLENERGELANEVKVLLQGKGDSE 1244
Query: 305 -----LEKSLKASQDAVTTSQSQYFSFREKIAAL------LRGRLSMTGSTEDTILEKIR 353
+E L+ Q + +K+ L + G LS + S + +
Sbjct: 1245 HKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFS 1304
Query: 354 EMDSREESRDRMVSQLEAQ---ISELVEQLGKESGFHQKALQRAQKAENMLE----TLQG 406
++S+ + ++ + Q +S ++Q+ E ++ L+ ++A++ LE TL
Sbjct: 1305 ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364
Query: 407 QLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKM--------KLDQMAAELGFDMRL 458
Q+ ++ ++ + K+K K L+ LSQ+ KL++ L L
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRL--QQEL 1422
Query: 459 DVVLA----------RTEQLVRLESNAVIENKTI-AHNLQRKLKTQKERLESKELHMSLL 507
D +L E+ + + E KTI A + + + + E E + +SL
Sbjct: 1423 DDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLA 1482
Query: 508 R------QKIAQLEE-EKQARTA---LVVERDNAHLTIRNLQKKVERLQKELNTCRDLHT 557
R ++ A+LE KQ RT L+ +D+ ++ L+K L++++ +
Sbjct: 1483 RALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLE 1542
Query: 558 ELKAKLADTNELKIKTLEQTKAIE-----DLNKSRDQLEKMKEK---------------- 596
EL+ +L T + K++ +A++ DL +Q E+ K++
Sbjct: 1543 ELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDER 1602
Query: 597 --------AEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAE-KRE 647
A KKL +L+ A +N++ A + + ++MK + L++ RE
Sbjct: 1603 KQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASRE 1662
Query: 648 KQLADFREVVSQMLGLNVTSLALPD 672
+ LA +E ++ + + L +
Sbjct: 1663 EILAQAKENEKKLKSMEAEMIQLQE 1687
Score = 67.0 bits (162), Expect = 6e-11
Identities = 86/378 (22%), Positives = 161/378 (42%), Gaps = 31/378 (8%)
Query: 291 SKQEVSLLKKSSSEL---EKSLKASQ--DAVTTSQSQYFSFREKIAALLRGRLSMTGSTE 345
S+QE ++ K + EK L A + T QSQ + + ++ L+ + E
Sbjct: 841 SRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAE 900
Query: 346 DTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQ 405
E + ++++ + + LEA++ E E+ +K Q Q+ E LE +
Sbjct: 901 ----ELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEE 956
Query: 406 GQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLART 465
L+ E V+ L E+ L+ + K+ ++ E D + T
Sbjct: 957 SARQKLQLEKVTTEAKLKKLEEEQI----ILEDQNCKLAKEKKLLE---DRIAEFTTNLT 1009
Query: 466 EQLVRLESNAVIENK--TIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTA 523
E+ + +S A ++NK + +L+ +L+ ++++ + E L L ++ A
Sbjct: 1010 EEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQA 1069
Query: 524 LVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDL 583
+ E L KK E LQ L + + L EL+ + E + +E
Sbjct: 1070 QIAELK------MQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESE 1123
Query: 584 NKSRDQLEKMKEKAEKKLMSVKSEL-DTTEHEAKENKERARNMIEVVTSEMKTLKKSL-E 641
SR++ EK K ++L ++K+EL DT + A + + R++ E+ LKK+L E
Sbjct: 1124 RASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKR-----EQEVNILKKTLEE 1178
Query: 642 EAEKREKQLADFREVVSQ 659
EA+ E Q+ + R+ SQ
Sbjct: 1179 EAKTHEAQIQEMRQKHSQ 1196
Score = 32.7 bits (73), Expect = 1.2
Identities = 18/93 (19%), Positives = 44/93 (47%)
Query: 57 ECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALS 116
+ A +++ K+ + + + E YK+ + S+ L L+ +++E EEE+ +
Sbjct: 1831 QAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRAN 1890
Query: 117 TSKIRTEITAHAAIKENQELKKKVVELNEKLQK 149
S+ + + A + + ++V L KL++
Sbjct: 1891 ASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 112 bits (280), Expect = 1e-24
Identities = 162/763 (21%), Positives = 312/763 (40%), Gaps = 123/763 (16%)
Query: 19 EETYDHLSEVPVTREQLNHYRNVAQN---ARSELAATLVKFECAQSELQDLRSKMLSKEV 75
++ + L E+ QL +N+ Q A +EL A E +++R ++ +K+
Sbjct: 869 QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA----------EAEEMRVRLAAKKQ 918
Query: 76 SCQELKAEMESYKENNARKSSLLTSLRDRVQE------------------LEEESAALST 117
+E+ EME+ E DR Q+ LEEE AA
Sbjct: 919 ELEEILHEMEARLEEE----------EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968
Query: 118 SKIRTEITAHAAIK-----------ENQELKKKVVELNEKLQKCS---KENEENKKQVSK 163
++ ++TA A IK +N +L K+ L E++ + E EE K ++K
Sbjct: 969 LQLE-KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1027
Query: 164 NCRKHEEFLTQLRDCLDPDERNDK------------ASD-----EDLILKLRDLR----K 202
KHE +++L L +E++ + ASD DL ++ +L+ K
Sbjct: 1028 LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1087
Query: 203 ENEFVKGQIVILEETINVHEMEAKASRET---IMRLASEVNREQKKAASCTEEKEKLNQD 259
+ E ++ + L++ I K RE I L +++ E+ ++K L ++
Sbjct: 1088 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1147
Query: 260 LLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKAS------- 312
L EAL+ E++ + Q++ +QEV++LKK+ E +S +A
Sbjct: 1148 L-------EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1200
Query: 313 -QDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEA 371
AV Q F+ A L + + ++ D + ++R + ++ + +LEA
Sbjct: 1201 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD-LAGELRVLGQAKQEVEHKKKKLEA 1259
Query: 372 QISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQK 431
Q+ EL + + + K +N +E++ G L E + + +L+ + Q
Sbjct: 1260 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319
Query: 432 YLKFLDQ-----LSQKMKLDQMAAEL-GFDMRLDVVLARTEQLVRLESNAVIENKTIAHN 485
+ L + L+ KL Q+ E +LD + + L R S I+
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379
Query: 486 LQRKLKTQKERLESKELHMSLLRQKIAQLEEE--------------KQARTALVVERDNA 531
LQ T + E K+ + Q EE+ +Q LVV+ DN
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439
Query: 532 HLTIRNLQKKVER----LQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSR 587
+ NL+KK + L +E N E A+ E + K L +A+E+ +++
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1499
Query: 588 DQLE---KMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAE 644
++LE KM + + L+S K ++ HE +++K +E + ++++ L+ L+ E
Sbjct: 1500 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1559
Query: 645 KREKQLADFREVVSQMLGLNVTSLALPDYEIIKCLERLVHSHQ 687
+ +L + + ++ + + E + L+R +H ++
Sbjct: 1560 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602
Score = 104 bits (259), Expect = 3e-22
Identities = 171/770 (22%), Positives = 311/770 (40%), Gaps = 131/770 (17%)
Query: 17 APEETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVS 76
A EE + L + + L+ + + ++LA L A+ E++ + K+ E
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL---EAQ 1260
Query: 77 CQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQEL 136
QEL+++ + A L D+V +L+ E +++ E A K+ L
Sbjct: 1261 VQELQSKCSDGERARAE-------LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 137 KKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPD---ERNDKASDEDL 193
++ + E LQ E K VS R+ EE L+D LD + ++N + L
Sbjct: 1314 SSQLQDTQELLQ----EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369
Query: 194 ILKLRDLRKENEFVKGQIVILEETIN---------VHEMEAKAS-----RETIMRLASEV 239
++L D +K+ + + LEE + E KA+ +T RL E+
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429
Query: 240 NR------EQKKAASCTEEKEKLNQDLLS------------------------------- 262
+ Q++ S E+K++ LL+
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1489
Query: 263 -----AVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVT 317
A+EAKE LER K+ L A + +SK +V K+ ELEKS +A + +
Sbjct: 1490 RALEEALEAKEELERTNKM----LKAEMEDLVSSKDDVG---KNVHELEKSKRALETQME 1542
Query: 318 TSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELV 377
++Q +++ A +L + + + + R++ +R+E + QL+ Q+ E
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602
Query: 378 EQLGKESGFHQKALQRAQK-----------------------AENMLETLQGQLTHLEAE 414
+L E Q+AL A K A L LQ Q+ + E
Sbjct: 1603 TELEDER--KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660
Query: 415 LVSGGVLRDNLNF---EKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRL 471
L RD + E +K K L+ +++ D AAE R L + E L
Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA---RKQADLEKEELAEEL 1717
Query: 472 ES-----NAVIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEE-KQARTALV 525
S NA+ + K L+ ++ +E LE ++ +M + ++ + ++ +Q L
Sbjct: 1718 ASSLSGRNALQDEK---RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774
Query: 526 VERDNAHLTIRNLQKKVERLQKELNT-CRDLHTELKAKLADTN---ELKIKTLEQTKAIE 581
ER A + ++++ER KEL + ++ +K+K T E KI LE+ +E
Sbjct: 1775 TERSTAQKN-ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ--VE 1831
Query: 582 DLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLE 641
+ + K ++ +KKL + +++ A++ KE+A E + +K LK+ LE
Sbjct: 1832 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA----EKGNARVKQLKRQLE 1887
Query: 642 EAEKREKQLADFREVVSQMLGLNVTSLALPDYEIIKCLERLVHSHQHHFV 691
EAE+ +++ R + + L S E+ +L ++ FV
Sbjct: 1888 EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFV 1937
Score = 91.3 bits (225), Expect = 3e-18
Identities = 139/694 (20%), Positives = 288/694 (41%), Gaps = 103/694 (14%)
Query: 24 HLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAE 83
+L+E + L +N ++ SEL L K E ++ EL+ L+ K L+ +
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK----------LEGD 1063
Query: 84 MESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITA-HAAIKENQELKKKVVE 142
+ E A + + L+ ++ + EEE A + +++ EI + A+K+ +EL+ + +
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQLAKKEEELQA-ALARLDDEIAQKNNALKKIRELEGHISD 1122
Query: 143 LNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRK 202
L E L + +KQ + E T+L D LD A+ ++L K +
Sbjct: 1123 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD-----STATQQELRAK-----R 1172
Query: 203 ENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNR--EQKKAASCTEEK-----EK 255
E E + + EET + HE + + R+ + E+ EQ K A +K EK
Sbjct: 1173 EQEVTVLKKALDEETRS-HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1231
Query: 256 LNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDA 315
N DL + ++EV+ +++L A Q + + S +++ +EL + Q+
Sbjct: 1232 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQ---ELQSKCSDGERARAELNDKVHKLQNE 1288
Query: 316 VTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISE 375
V + K L + S++ +DT E ++E ++ + + QLE + +
Sbjct: 1289 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDT-QELLQEETRQKLNVSTKLRQLEEERNS 1347
Query: 376 LVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKF 435
L +QL +E ++ Q E + TL QL+ + +L + L K+++ K
Sbjct: 1348 LQDQLDEE-------MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 436 LDQLSQK-------------------MKLDQMAAELGFDMRLDVVLARTEQLVRLESNAV 476
++ L+Q+ +LD + +L +L ++ E+ R +
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL---VSNLEKKQRKFDQLL 1457
Query: 477 IENKTIAHNL---QRKLKTQKERLESKELHMSLLRQKIAQLEEE--------KQARTALV 525
E K I+ + + + + E+K L ++ ++ + +EE K LV
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517
Query: 526 VERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIE---- 581
+D+ + L+K L+ ++ + EL+ +L T + K++ +A++
Sbjct: 1518 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1577
Query: 582 -DLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHE------------------------AK 616
DL +Q E+ + + +++L ++EL+ + A
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637
Query: 617 ENKERARNMIEVVTSEMKTLKKSLEEAEKREKQL 650
+ +E A + + ++MK ++ LE+A ++
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Score = 84.3 bits (207), Expect = 3e-16
Identities = 126/603 (20%), Positives = 241/603 (39%), Gaps = 43/603 (7%)
Query: 15 SPAPEETYDHLSEVPVTREQLNHYRNVAQNARS---ELAATLVKFECA----QSELQDLR 67
S + ++ D S V E ++ +N E AA K E Q EL DL
Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1433
Query: 68 SKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAH 127
+ ++ L+ + + + A + ++ + D E E+ T +
Sbjct: 1434 VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1493
Query: 128 AAIKENQELKKKVVELNEKLQKCSKENEE---NKKQVSKNCRKHEEFLTQLRDCLDPDER 184
A++ +EL++ L +++ ++ N ++ K+ R E + +++ L+ E
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1553
Query: 185 NDKASDEDLILKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMR----LASEVN 240
+A+++ KLR L + +KGQ E + + + + R + R +E+
Sbjct: 1554 ELQATED---AKLR-LEVNMQALKGQF---ERDLQARDEQNEEKRRQLQRQLHEYETELE 1606
Query: 241 REQKKAASCTEEKEKLNQDLLSA-VEAKEALE-REVKIFQERLLAGQQVWDASKQEVSLL 298
E+K+ A K+KL DL ++A A++ RE I Q R L Q ++E+
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM--KDFQRELEDA 1664
Query: 299 KKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSR 358
+ S E+ + K ++ + ++ +E +AA R R E+ E + R
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724
Query: 359 EESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSG 418
+D +LEA+I++L E+L +E G + R +KA E L +L +
Sbjct: 1725 NALQDEK-RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783
Query: 419 GVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIE 478
R L E+Q +L K+ + A + F + + A+ QL E
Sbjct: 1784 ESARQQL--ERQN-----KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1836
Query: 479 NKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNL 538
+ +L++K K KE L E + Q Q E+ L + + A + +
Sbjct: 1837 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1896
Query: 539 QKKVERLQKELNTCRDLH-------TELKAKLADTNELKIKTLEQT---KAIEDLNKSRD 588
+LQ+EL+ + + LK+KL NE ++ + IE+ + S +
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEE 1956
Query: 589 QLE 591
+ +
Sbjct: 1957 ETD 1959
Score = 60.8 bits (146), Expect = 4e-09
Identities = 67/314 (21%), Positives = 140/314 (44%), Gaps = 64/314 (20%)
Query: 372 QISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQK 431
Q++ E++ + QK +R QKAEN L+ L+ + + L E +L++ L E +
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK---NLLQEQLQAETEL 902
Query: 432 YLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLK 491
Y + +++M+ V LA +Q E + I H ++ +L+
Sbjct: 903 YAE-----AEEMR---------------VRLAAKKQ----------ELEEILHEMEARLE 932
Query: 492 TQKERLESKELHMSLLRQKIA----QLEEEKQARTALVVERDNAHLTIRNLQKKV----- 542
+++R + + + Q++ QLEEE+ AR L +E+ A I+ L+ ++
Sbjct: 933 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992
Query: 543 --ERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTK------------AIEDLNKSRD 588
+L KE + ++L LA+ E K K L + K ++ KSR
Sbjct: 993 QNNKLSKERKLLEERISDLTTNLAEEEE-KAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1051
Query: 589 QLEKMKEKAE-------KKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLE 641
+LEK+K K E +++ +++++ + + + +E + + + E+ +L+
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1111
Query: 642 EAEKREKQLADFRE 655
+ + E ++D +E
Sbjct: 1112 KIRELEGHISDLQE 1125
Score = 39.3 bits (90), Expect = 0.013
Identities = 31/151 (20%), Positives = 71/151 (47%), Gaps = 9/151 (5%)
Query: 41 VAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTS 100
V Q AR + AAT L+ K+ + ++ + E YKE + ++ +
Sbjct: 1830 VEQEAREKQAAT--------KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1881
Query: 101 LRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVELNEKLQKCSKEN-EENKK 159
L+ +++E EEES ++ ++ + + A + N+ + ++V L KL++ ++ + +++
Sbjct: 1882 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRR 1941
Query: 160 QVSKNCRKHEEFLTQLRDCLDPDERNDKASD 190
+ ++ + + D D D KAS+
Sbjct: 1942 SGGRRVIENADGSEEETDTRDADFNGTKASE 1972
Score = 32.3 bits (72), Expect = 1.6
Identities = 41/162 (25%), Positives = 77/162 (47%), Gaps = 27/162 (16%)
Query: 516 EEKQARTALVVERDN--AHLTIRNLQ-----------KKVERLQKELNTCRDLHTELKAK 562
+ +Q TA+ V + N A+L +RN Q +V R ++E+ D + K +
Sbjct: 808 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 867
Query: 563 LADT-NELKIKTLEQTKAIEDLNKSRDQLEKMKE---KAEK---KLMSVKSELDTTEHE- 614
NELK + ++ E+ N ++QL+ E +AE+ +L + K EL+ HE
Sbjct: 868 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 927
Query: 615 ---AKENKERARNM---IEVVTSEMKTLKKSLEEAEKREKQL 650
+E ++R + + + + +M L++ LEE E ++L
Sbjct: 928 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 112 bits (280), Expect = 1e-24
Identities = 162/763 (21%), Positives = 312/763 (40%), Gaps = 123/763 (16%)
Query: 19 EETYDHLSEVPVTREQLNHYRNVAQN---ARSELAATLVKFECAQSELQDLRSKMLSKEV 75
++ + L E+ QL +N+ Q A +EL A E +++R ++ +K+
Sbjct: 876 QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA----------EAEEMRVRLAAKKQ 925
Query: 76 SCQELKAEMESYKENNARKSSLLTSLRDRVQE------------------LEEESAALST 117
+E+ EME+ E DR Q+ LEEE AA
Sbjct: 926 ELEEILHEMEARLEEE----------EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975
Query: 118 SKIRTEITAHAAIK-----------ENQELKKKVVELNEKLQKCS---KENEENKKQVSK 163
++ ++TA A IK +N +L K+ L E++ + E EE K ++K
Sbjct: 976 LQLE-KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1034
Query: 164 NCRKHEEFLTQLRDCLDPDERNDK------------ASD-----EDLILKLRDLR----K 202
KHE +++L L +E++ + ASD DL ++ +L+ K
Sbjct: 1035 LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1094
Query: 203 ENEFVKGQIVILEETINVHEMEAKASRET---IMRLASEVNREQKKAASCTEEKEKLNQD 259
+ E ++ + L++ I K RE I L +++ E+ ++K L ++
Sbjct: 1095 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1154
Query: 260 LLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKAS------- 312
L EAL+ E++ + Q++ +QEV++LKK+ E +S +A
Sbjct: 1155 L-------EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1207
Query: 313 -QDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEA 371
AV Q F+ A L + + ++ D + ++R + ++ + +LEA
Sbjct: 1208 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD-LAGELRVLGQAKQEVEHKKKKLEA 1266
Query: 372 QISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQK 431
Q+ EL + + + K +N +E++ G L E + + +L+ + Q
Sbjct: 1267 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326
Query: 432 YLKFLDQ-----LSQKMKLDQMAAEL-GFDMRLDVVLARTEQLVRLESNAVIENKTIAHN 485
+ L + L+ KL Q+ E +LD + + L R S I+
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386
Query: 486 LQRKLKTQKERLESKELHMSLLRQKIAQLEEE--------------KQARTALVVERDNA 531
LQ T + E K+ + Q EE+ +Q LVV+ DN
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446
Query: 532 HLTIRNLQKKVER----LQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSR 587
+ NL+KK + L +E N E A+ E + K L +A+E+ +++
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1506
Query: 588 DQLE---KMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAE 644
++LE KM + + L+S K ++ HE +++K +E + ++++ L+ L+ E
Sbjct: 1507 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1566
Query: 645 KREKQLADFREVVSQMLGLNVTSLALPDYEIIKCLERLVHSHQ 687
+ +L + + ++ + + E + L+R +H ++
Sbjct: 1567 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609
Score = 104 bits (259), Expect = 3e-22
Identities = 171/770 (22%), Positives = 311/770 (40%), Gaps = 131/770 (17%)
Query: 17 APEETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVS 76
A EE + L + + L+ + + ++LA L A+ E++ + K+ E
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL---EAQ 1267
Query: 77 CQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQEL 136
QEL+++ + A L D+V +L+ E +++ E A K+ L
Sbjct: 1268 VQELQSKCSDGERARAE-------LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 137 KKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPD---ERNDKASDEDL 193
++ + E LQ E K VS R+ EE L+D LD + ++N + L
Sbjct: 1321 SSQLQDTQELLQ----EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376
Query: 194 ILKLRDLRKENEFVKGQIVILEETIN---------VHEMEAKAS-----RETIMRLASEV 239
++L D +K+ + + LEE + E KA+ +T RL E+
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436
Query: 240 NR------EQKKAASCTEEKEKLNQDLLS------------------------------- 262
+ Q++ S E+K++ LL+
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1496
Query: 263 -----AVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVT 317
A+EAKE LER K+ L A + +SK +V K+ ELEKS +A + +
Sbjct: 1497 RALEEALEAKEELERTNKM----LKAEMEDLVSSKDDVG---KNVHELEKSKRALETQME 1549
Query: 318 TSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELV 377
++Q +++ A +L + + + + R++ +R+E + QL+ Q+ E
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609
Query: 378 EQLGKESGFHQKALQRAQK-----------------------AENMLETLQGQLTHLEAE 414
+L E Q+AL A K A L LQ Q+ + E
Sbjct: 1610 TELEDER--KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667
Query: 415 LVSGGVLRDNLNF---EKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRL 471
L RD + E +K K L+ +++ D AAE R L + E L
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA---RKQADLEKEELAEEL 1724
Query: 472 ES-----NAVIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEE-KQARTALV 525
S NA+ + K L+ ++ +E LE ++ +M + ++ + ++ +Q L
Sbjct: 1725 ASSLSGRNALQDEK---RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781
Query: 526 VERDNAHLTIRNLQKKVERLQKELNT-CRDLHTELKAKLADTN---ELKIKTLEQTKAIE 581
ER A + ++++ER KEL + ++ +K+K T E KI LE+ +E
Sbjct: 1782 TERSTAQKN-ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ--VE 1838
Query: 582 DLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLE 641
+ + K ++ +KKL + +++ A++ KE+A E + +K LK+ LE
Sbjct: 1839 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA----EKGNARVKQLKRQLE 1894
Query: 642 EAEKREKQLADFREVVSQMLGLNVTSLALPDYEIIKCLERLVHSHQHHFV 691
EAE+ +++ R + + L S E+ +L ++ FV
Sbjct: 1895 EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFV 1944
Score = 91.3 bits (225), Expect = 3e-18
Identities = 139/694 (20%), Positives = 288/694 (41%), Gaps = 103/694 (14%)
Query: 24 HLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAE 83
+L+E + L +N ++ SEL L K E ++ EL+ L+ K L+ +
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK----------LEGD 1070
Query: 84 MESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITA-HAAIKENQELKKKVVE 142
+ E A + + L+ ++ + EEE A + +++ EI + A+K+ +EL+ + +
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQLAKKEEELQA-ALARLDDEIAQKNNALKKIRELEGHISD 1129
Query: 143 LNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRK 202
L E L + +KQ + E T+L D LD A+ ++L K +
Sbjct: 1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD-----STATQQELRAK-----R 1179
Query: 203 ENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNR--EQKKAASCTEEK-----EK 255
E E + + EET + HE + + R+ + E+ EQ K A +K EK
Sbjct: 1180 EQEVTVLKKALDEETRS-HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1238
Query: 256 LNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDA 315
N DL + ++EV+ +++L A Q + + S +++ +EL + Q+
Sbjct: 1239 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQ---ELQSKCSDGERARAELNDKVHKLQNE 1295
Query: 316 VTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISE 375
V + K L + S++ +DT E ++E ++ + + QLE + +
Sbjct: 1296 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDT-QELLQEETRQKLNVSTKLRQLEEERNS 1354
Query: 376 LVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKF 435
L +QL +E ++ Q E + TL QL+ + +L + L K+++ K
Sbjct: 1355 LQDQLDEE-------MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 436 LDQLSQK-------------------MKLDQMAAELGFDMRLDVVLARTEQLVRLESNAV 476
++ L+Q+ +LD + +L +L ++ E+ R +
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL---VSNLEKKQRKFDQLL 1464
Query: 477 IENKTIAHNL---QRKLKTQKERLESKELHMSLLRQKIAQLEEE--------KQARTALV 525
E K I+ + + + + E+K L ++ ++ + +EE K LV
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524
Query: 526 VERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIE---- 581
+D+ + L+K L+ ++ + EL+ +L T + K++ +A++
Sbjct: 1525 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1584
Query: 582 -DLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHE------------------------AK 616
DL +Q E+ + + +++L ++EL+ + A
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644
Query: 617 ENKERARNMIEVVTSEMKTLKKSLEEAEKREKQL 650
+ +E A + + ++MK ++ LE+A ++
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Score = 84.3 bits (207), Expect = 3e-16
Identities = 126/603 (20%), Positives = 241/603 (39%), Gaps = 43/603 (7%)
Query: 15 SPAPEETYDHLSEVPVTREQLNHYRNVAQNARS---ELAATLVKFECA----QSELQDLR 67
S + ++ D S V E ++ +N E AA K E Q EL DL
Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1440
Query: 68 SKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAH 127
+ ++ L+ + + + A + ++ + D E E+ T +
Sbjct: 1441 VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1500
Query: 128 AAIKENQELKKKVVELNEKLQKCSKENEE---NKKQVSKNCRKHEEFLTQLRDCLDPDER 184
A++ +EL++ L +++ ++ N ++ K+ R E + +++ L+ E
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1560
Query: 185 NDKASDEDLILKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMR----LASEVN 240
+A+++ KLR L + +KGQ E + + + + R + R +E+
Sbjct: 1561 ELQATED---AKLR-LEVNMQALKGQF---ERDLQARDEQNEEKRRQLQRQLHEYETELE 1613
Query: 241 REQKKAASCTEEKEKLNQDLLSA-VEAKEALE-REVKIFQERLLAGQQVWDASKQEVSLL 298
E+K+ A K+KL DL ++A A++ RE I Q R L Q ++E+
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM--KDFQRELEDA 1671
Query: 299 KKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSR 358
+ S E+ + K ++ + ++ +E +AA R R E+ E + R
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731
Query: 359 EESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSG 418
+D +LEA+I++L E+L +E G + R +KA E L +L +
Sbjct: 1732 NALQDEK-RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790
Query: 419 GVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIE 478
R L E+Q +L K+ + A + F + + A+ QL E
Sbjct: 1791 ESARQQL--ERQN-----KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1843
Query: 479 NKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNL 538
+ +L++K K KE L E + Q Q E+ L + + A + +
Sbjct: 1844 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1903
Query: 539 QKKVERLQKELNTCRDLH-------TELKAKLADTNELKIKTLEQT---KAIEDLNKSRD 588
+LQ+EL+ + + LK+KL NE ++ + IE+ + S +
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEE 1963
Query: 589 QLE 591
+ +
Sbjct: 1964 ETD 1966
Score = 60.8 bits (146), Expect = 4e-09
Identities = 67/314 (21%), Positives = 140/314 (44%), Gaps = 64/314 (20%)
Query: 372 QISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQK 431
Q++ E++ + QK +R QKAEN L+ L+ + + L E +L++ L E +
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK---NLLQEQLQAETEL 909
Query: 432 YLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLK 491
Y + +++M+ V LA +Q E + I H ++ +L+
Sbjct: 910 YAE-----AEEMR---------------VRLAAKKQ----------ELEEILHEMEARLE 939
Query: 492 TQKERLESKELHMSLLRQKIA----QLEEEKQARTALVVERDNAHLTIRNLQKKV----- 542
+++R + + + Q++ QLEEE+ AR L +E+ A I+ L+ ++
Sbjct: 940 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999
Query: 543 --ERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTK------------AIEDLNKSRD 588
+L KE + ++L LA+ E K K L + K ++ KSR
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEEE-KAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1058
Query: 589 QLEKMKEKAE-------KKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLE 641
+LEK+K K E +++ +++++ + + + +E + + + E+ +L+
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1118
Query: 642 EAEKREKQLADFRE 655
+ + E ++D +E
Sbjct: 1119 KIRELEGHISDLQE 1132
Score = 39.3 bits (90), Expect = 0.013
Identities = 31/151 (20%), Positives = 71/151 (47%), Gaps = 9/151 (5%)
Query: 41 VAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTS 100
V Q AR + AAT L+ K+ + ++ + E YKE + ++ +
Sbjct: 1837 VEQEAREKQAAT--------KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1888
Query: 101 LRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVELNEKLQKCSKEN-EENKK 159
L+ +++E EEES ++ ++ + + A + N+ + ++V L KL++ ++ + +++
Sbjct: 1889 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRR 1948
Query: 160 QVSKNCRKHEEFLTQLRDCLDPDERNDKASD 190
+ ++ + + D D D KAS+
Sbjct: 1949 SGGRRVIENADGSEEETDTRDADFNGTKASE 1979
Score = 32.3 bits (72), Expect = 1.6
Identities = 41/162 (25%), Positives = 77/162 (47%), Gaps = 27/162 (16%)
Query: 516 EEKQARTALVVERDN--AHLTIRNLQ-----------KKVERLQKELNTCRDLHTELKAK 562
+ +Q TA+ V + N A+L +RN Q +V R ++E+ D + K +
Sbjct: 815 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 874
Query: 563 LADT-NELKIKTLEQTKAIEDLNKSRDQLEKMKE---KAEK---KLMSVKSELDTTEHE- 614
NELK + ++ E+ N ++QL+ E +AE+ +L + K EL+ HE
Sbjct: 875 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 934
Query: 615 ---AKENKERARNM---IEVVTSEMKTLKKSLEEAEKREKQL 650
+E ++R + + + + +M L++ LEE E ++L
Sbjct: 935 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 112 bits (280), Expect = 1e-24
Identities = 162/763 (21%), Positives = 312/763 (40%), Gaps = 123/763 (16%)
Query: 19 EETYDHLSEVPVTREQLNHYRNVAQN---ARSELAATLVKFECAQSELQDLRSKMLSKEV 75
++ + L E+ QL +N+ Q A +EL A E +++R ++ +K+
Sbjct: 876 QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA----------EAEEMRVRLAAKKQ 925
Query: 76 SCQELKAEMESYKENNARKSSLLTSLRDRVQE------------------LEEESAALST 117
+E+ EME+ E DR Q+ LEEE AA
Sbjct: 926 ELEEILHEMEARLEEE----------EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975
Query: 118 SKIRTEITAHAAIK-----------ENQELKKKVVELNEKLQKCS---KENEENKKQVSK 163
++ ++TA A IK +N +L K+ L E++ + E EE K ++K
Sbjct: 976 LQLE-KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1034
Query: 164 NCRKHEEFLTQLRDCLDPDERNDK------------ASD-----EDLILKLRDLR----K 202
KHE +++L L +E++ + ASD DL ++ +L+ K
Sbjct: 1035 LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1094
Query: 203 ENEFVKGQIVILEETINVHEMEAKASRET---IMRLASEVNREQKKAASCTEEKEKLNQD 259
+ E ++ + L++ I K RE I L +++ E+ ++K L ++
Sbjct: 1095 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1154
Query: 260 LLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKAS------- 312
L EAL+ E++ + Q++ +QEV++LKK+ E +S +A
Sbjct: 1155 L-------EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1207
Query: 313 -QDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEA 371
AV Q F+ A L + + ++ D + ++R + ++ + +LEA
Sbjct: 1208 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD-LAGELRVLGQAKQEVEHKKKKLEA 1266
Query: 372 QISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQK 431
Q+ EL + + + K +N +E++ G L E + + +L+ + Q
Sbjct: 1267 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326
Query: 432 YLKFLDQ-----LSQKMKLDQMAAEL-GFDMRLDVVLARTEQLVRLESNAVIENKTIAHN 485
+ L + L+ KL Q+ E +LD + + L R S I+
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386
Query: 486 LQRKLKTQKERLESKELHMSLLRQKIAQLEEE--------------KQARTALVVERDNA 531
LQ T + E K+ + Q EE+ +Q LVV+ DN
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446
Query: 532 HLTIRNLQKKVER----LQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSR 587
+ NL+KK + L +E N E A+ E + K L +A+E+ +++
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1506
Query: 588 DQLE---KMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAE 644
++LE KM + + L+S K ++ HE +++K +E + ++++ L+ L+ E
Sbjct: 1507 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1566
Query: 645 KREKQLADFREVVSQMLGLNVTSLALPDYEIIKCLERLVHSHQ 687
+ +L + + ++ + + E + L+R +H ++
Sbjct: 1567 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609
Score = 103 bits (258), Expect = 4e-22
Identities = 164/729 (22%), Positives = 298/729 (40%), Gaps = 131/729 (17%)
Query: 17 APEETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVS 76
A EE + L + + L+ + + ++LA L A+ E++ + K+ E
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL---EAQ 1267
Query: 77 CQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQEL 136
QEL+++ + A L D+V +L+ E +++ E A K+ L
Sbjct: 1268 VQELQSKCSDGERARAE-------LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 137 KKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPD---ERNDKASDEDL 193
++ + E LQ E K VS R+ EE L+D LD + ++N + L
Sbjct: 1321 SSQLQDTQELLQ----EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376
Query: 194 ILKLRDLRKENEFVKGQIVILEETIN---------VHEMEAKAS-----RETIMRLASEV 239
++L D +K+ + + LEE + E KA+ +T RL E+
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436
Query: 240 NR------EQKKAASCTEEKEKLNQDLLS------------------------------- 262
+ Q++ S E+K++ LL+
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1496
Query: 263 -----AVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVT 317
A+EAKE LER K+ L A + +SK +V K+ ELEKS +A + +
Sbjct: 1497 RALEEALEAKEELERTNKM----LKAEMEDLVSSKDDVG---KNVHELEKSKRALETQME 1549
Query: 318 TSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELV 377
++Q +++ A +L + + + + R++ +R+E + QL+ Q+ E
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609
Query: 378 EQLGKESGFHQKALQRAQK-----------------------AENMLETLQGQLTHLEAE 414
+L E Q+AL A K A L LQ Q+ + E
Sbjct: 1610 TELEDER--KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667
Query: 415 LVSGGVLRDNLNF---EKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRL 471
L RD + E +K K L+ +++ D AAE R L + E L
Sbjct: 1668 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA---RKQADLEKEELAEEL 1724
Query: 472 ES-----NAVIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEE-KQARTALV 525
S NA+ + K L+ ++ +E LE ++ +M + ++ + ++ +Q L
Sbjct: 1725 ASSLSGRNALQDEK---RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781
Query: 526 VERDNAHLTIRNLQKKVERLQKELNT-CRDLHTELKAKLADTN---ELKIKTLEQTKAIE 581
ER A + ++++ER KEL + ++ +K+K T E KI LE+ +E
Sbjct: 1782 TERSTAQKN-ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ--VE 1838
Query: 582 DLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLE 641
+ + K ++ +KKL + +++ A++ KE+A E + +K LK+ LE
Sbjct: 1839 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA----EKGNARVKQLKRQLE 1894
Query: 642 EAEKREKQL 650
EAE+ +++
Sbjct: 1895 EAEEESQRI 1903
Score = 91.3 bits (225), Expect = 3e-18
Identities = 139/694 (20%), Positives = 288/694 (41%), Gaps = 103/694 (14%)
Query: 24 HLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAE 83
+L+E + L +N ++ SEL L K E ++ EL+ L+ K L+ +
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK----------LEGD 1070
Query: 84 MESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITA-HAAIKENQELKKKVVE 142
+ E A + + L+ ++ + EEE A + +++ EI + A+K+ +EL+ + +
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQLAKKEEELQA-ALARLDDEIAQKNNALKKIRELEGHISD 1129
Query: 143 LNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRK 202
L E L + +KQ + E T+L D LD A+ ++L K +
Sbjct: 1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD-----STATQQELRAK-----R 1179
Query: 203 ENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNR--EQKKAASCTEEK-----EK 255
E E + + EET + HE + + R+ + E+ EQ K A +K EK
Sbjct: 1180 EQEVTVLKKALDEETRS-HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1238
Query: 256 LNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDA 315
N DL + ++EV+ +++L A Q + + S +++ +EL + Q+
Sbjct: 1239 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQ---ELQSKCSDGERARAELNDKVHKLQNE 1295
Query: 316 VTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISE 375
V + K L + S++ +DT E ++E ++ + + QLE + +
Sbjct: 1296 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDT-QELLQEETRQKLNVSTKLRQLEEERNS 1354
Query: 376 LVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKF 435
L +QL +E ++ Q E + TL QL+ + +L + L K+++ K
Sbjct: 1355 LQDQLDEE-------MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 436 LDQLSQK-------------------MKLDQMAAELGFDMRLDVVLARTEQLVRLESNAV 476
++ L+Q+ +LD + +L +L ++ E+ R +
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL---VSNLEKKQRKFDQLL 1464
Query: 477 IENKTIAHNL---QRKLKTQKERLESKELHMSLLRQKIAQLEEE--------KQARTALV 525
E K I+ + + + + E+K L ++ ++ + +EE K LV
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524
Query: 526 VERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIE---- 581
+D+ + L+K L+ ++ + EL+ +L T + K++ +A++
Sbjct: 1525 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1584
Query: 582 -DLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHE------------------------AK 616
DL +Q E+ + + +++L ++EL+ + A
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644
Query: 617 ENKERARNMIEVVTSEMKTLKKSLEEAEKREKQL 650
+ +E A + + ++MK ++ LE+A ++
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Score = 88.2 bits (217), Expect = 2e-17
Identities = 132/638 (20%), Positives = 264/638 (41%), Gaps = 78/638 (12%)
Query: 32 REQLNHYRNVAQNARSELAATLVKFECAQSELQDLRS---------KMLSKEVS--CQEL 80
++QL+ QN ++ ++ ++ +LQD S K KE+ Q+
Sbjct: 1356 QDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1415
Query: 81 KAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKV 140
+ + +Y + K+ L L D V +L+ + +S + + + + E + + K
Sbjct: 1416 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE-KKQRKFDQLLAEEKNISSKY 1474
Query: 141 VELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDL 200
+ ++ + ++E E ++ R EE L + ++ L+ + KA EDL+ D+
Sbjct: 1475 ADERDRAEAEAREKETKALSLA---RALEEAL-EAKEELERTNKMLKAEMEDLVSSKDDV 1530
Query: 201 RKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDL 260
K NVHE+E K+ R A E E+ K + E+L +L
Sbjct: 1531 GK----------------NVHELE-KSKR------ALETQMEEMKT-----QLEELEDEL 1562
Query: 261 LSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQ 320
+ +AK LE ++ + + Q D +E +L++ L + + +
Sbjct: 1563 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEE------KRRQLQRQLHEYETELEDER 1616
Query: 321 SQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQL 380
Q +AA + +L G +D L+ + REE+ + + +L+AQ+ + +L
Sbjct: 1617 KQ-----RALAAAAKKKLE--GDLKDLELQADSAIKGREEA-IKQLRKLQAQMKDFQREL 1668
Query: 381 GKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFL-DQL 439
+ A++ E ++L+ L L+ +L + R + EK++ + L L
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728
Query: 440 SQKMKLDQMAAELGFDM-RLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLE 498
S + L L + +L+ L + + S+ V + A L +L T++ +
Sbjct: 1729 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1788
Query: 499 SKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTE 558
E L ++ +L + V + + TI L+ K+ +L+++ + E
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKS--TIAALEAKIAQLEEQ------VEQE 1840
Query: 559 LKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKEN 618
+ K A T LK K + + + + R E+ KE+AEK VK +L EA+E
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK-QLKRQLEEAEEE 1899
Query: 619 KERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREV 656
+R + + + L++ L+EA + + + REV
Sbjct: 1900 SQR-------INANRRKLQRELDEATESNEAMG--REV 1928
Score = 83.2 bits (204), Expect = 8e-16
Identities = 122/574 (21%), Positives = 230/574 (40%), Gaps = 36/574 (6%)
Query: 15 SPAPEETYDHLSEVPVTREQLNHYRNVAQNARS---ELAATLVKFECA----QSELQDLR 67
S + ++ D S V E ++ +N E AA K E Q EL DL
Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1440
Query: 68 SKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAH 127
+ ++ L+ + + + A + ++ + D E E+ T +
Sbjct: 1441 VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1500
Query: 128 AAIKENQELKKKVVELNEKLQKCSKENEE---NKKQVSKNCRKHEEFLTQLRDCLDPDER 184
A++ +EL++ L +++ ++ N ++ K+ R E + +++ L+ E
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1560
Query: 185 NDKASDEDLILKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMR----LASEVN 240
+A+++ KLR L + +KGQ E + + + + R + R +E+
Sbjct: 1561 ELQATED---AKLR-LEVNMQALKGQF---ERDLQARDEQNEEKRRQLQRQLHEYETELE 1613
Query: 241 REQKKAASCTEEKEKLNQDLLSA-VEAKEALE-REVKIFQERLLAGQQVWDASKQEVSLL 298
E+K+ A K+KL DL ++A A++ RE I Q R L Q ++E+
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM--KDFQRELEDA 1671
Query: 299 KKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSR 358
+ S E+ + K ++ + ++ +E +AA R R E+ E + R
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1731
Query: 359 EESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSG 418
+D +LEA+I++L E+L +E G + R +KA E L +L +
Sbjct: 1732 NALQDEK-RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790
Query: 419 GVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIE 478
R L E+Q +L K+ + A + F + + A+ QL E
Sbjct: 1791 ESARQQL--ERQN-----KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1843
Query: 479 NKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNL 538
+ +L++K K KE L E + Q Q E+ L + + A + +
Sbjct: 1844 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1903
Query: 539 QKKVERLQKELNTCRDLHTELKAKLADTNELKIK 572
+LQ+EL+ + + +A + N LK K
Sbjct: 1904 NANRRKLQRELDEATESN---EAMGREVNALKSK 1934
Score = 60.8 bits (146), Expect = 4e-09
Identities = 67/314 (21%), Positives = 140/314 (44%), Gaps = 64/314 (20%)
Query: 372 QISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQK 431
Q++ E++ + QK +R QKAEN L+ L+ + + L E +L++ L E +
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK---NLLQEQLQAETEL 909
Query: 432 YLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLK 491
Y + +++M+ V LA +Q E + I H ++ +L+
Sbjct: 910 YAE-----AEEMR---------------VRLAAKKQ----------ELEEILHEMEARLE 939
Query: 492 TQKERLESKELHMSLLRQKIA----QLEEEKQARTALVVERDNAHLTIRNLQKKV----- 542
+++R + + + Q++ QLEEE+ AR L +E+ A I+ L+ ++
Sbjct: 940 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999
Query: 543 --ERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTK------------AIEDLNKSRD 588
+L KE + ++L LA+ E K K L + K ++ KSR
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEEE-KAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1058
Query: 589 QLEKMKEKAE-------KKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLE 641
+LEK+K K E +++ +++++ + + + +E + + + E+ +L+
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1118
Query: 642 EAEKREKQLADFRE 655
+ + E ++D +E
Sbjct: 1119 KIRELEGHISDLQE 1132
Score = 55.8 bits (133), Expect = 1e-07
Identities = 51/243 (20%), Positives = 109/243 (44%), Gaps = 17/243 (6%)
Query: 39 RNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLL 98
R A + ELA L ++ LQD + ++ E +L+ E+E + N +
Sbjct: 1710 RKQADLEKEELAEELASSLSGRNALQDEKRRL---EARIAQLEEELEEEQGN-------M 1759
Query: 99 TSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVELNEKLQKCSKENEENK 158
++ DRV++ +++ LS TA Q+L+++ EL KL + K
Sbjct: 1760 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV---K 1816
Query: 159 KQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRKENEFVKGQIVILEETI 218
+ E + QL + ++ + R +A+ + L K + L++ V+ + + E+
Sbjct: 1817 SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ-- 1874
Query: 219 NVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLLSAVEAKEALEREVKIFQ 278
++ +A+ + +L ++ ++++ + KL ++L A E+ EA+ REV +
Sbjct: 1875 --YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1932
Query: 279 ERL 281
+L
Sbjct: 1933 SKL 1935
Score = 37.0 bits (84), Expect = 0.064
Identities = 25/108 (23%), Positives = 52/108 (48%), Gaps = 8/108 (7%)
Query: 41 VAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTS 100
V Q AR + AAT L+ K+ + ++ + E YKE + ++ +
Sbjct: 1837 VEQEAREKQAAT--------KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1888
Query: 101 LRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVELNEKLQ 148
L+ +++E EEES ++ ++ + + A + N+ + ++V L KL+
Sbjct: 1889 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 32.3 bits (72), Expect = 1.6
Identities = 41/162 (25%), Positives = 77/162 (47%), Gaps = 27/162 (16%)
Query: 516 EEKQARTALVVERDN--AHLTIRNLQ-----------KKVERLQKELNTCRDLHTELKAK 562
+ +Q TA+ V + N A+L +RN Q +V R ++E+ D + K +
Sbjct: 815 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 874
Query: 563 LADT-NELKIKTLEQTKAIEDLNKSRDQLEKMKE---KAEK---KLMSVKSELDTTEHE- 614
NELK + ++ E+ N ++QL+ E +AE+ +L + K EL+ HE
Sbjct: 875 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 934
Query: 615 ---AKENKERARNM---IEVVTSEMKTLKKSLEEAEKREKQL 650
+E ++R + + + + +M L++ LEE E ++L
Sbjct: 935 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 976
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 112 bits (280), Expect = 1e-24
Identities = 162/763 (21%), Positives = 312/763 (40%), Gaps = 123/763 (16%)
Query: 19 EETYDHLSEVPVTREQLNHYRNVAQN---ARSELAATLVKFECAQSELQDLRSKMLSKEV 75
++ + L E+ QL +N+ Q A +EL A E +++R ++ +K+
Sbjct: 869 QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA----------EAEEMRVRLAAKKQ 918
Query: 76 SCQELKAEMESYKENNARKSSLLTSLRDRVQE------------------LEEESAALST 117
+E+ EME+ E DR Q+ LEEE AA
Sbjct: 919 ELEEILHEMEARLEEE----------EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968
Query: 118 SKIRTEITAHAAIK-----------ENQELKKKVVELNEKLQKCS---KENEENKKQVSK 163
++ ++TA A IK +N +L K+ L E++ + E EE K ++K
Sbjct: 969 LQLE-KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1027
Query: 164 NCRKHEEFLTQLRDCLDPDERNDK------------ASD-----EDLILKLRDLR----K 202
KHE +++L L +E++ + ASD DL ++ +L+ K
Sbjct: 1028 LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK 1087
Query: 203 ENEFVKGQIVILEETINVHEMEAKASRET---IMRLASEVNREQKKAASCTEEKEKLNQD 259
+ E ++ + L++ I K RE I L +++ E+ ++K L ++
Sbjct: 1088 KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1147
Query: 260 LLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKAS------- 312
L EAL+ E++ + Q++ +QEV++LKK+ E +S +A
Sbjct: 1148 L-------EALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1200
Query: 313 -QDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEA 371
AV Q F+ A L + + ++ D + ++R + ++ + +LEA
Sbjct: 1201 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD-LAGELRVLGQAKQEVEHKKKKLEA 1259
Query: 372 QISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQK 431
Q+ EL + + + K +N +E++ G L E + + +L+ + Q
Sbjct: 1260 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319
Query: 432 YLKFLDQ-----LSQKMKLDQMAAEL-GFDMRLDVVLARTEQLVRLESNAVIENKTIAHN 485
+ L + L+ KL Q+ E +LD + + L R S I+
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379
Query: 486 LQRKLKTQKERLESKELHMSLLRQKIAQLEEE--------------KQARTALVVERDNA 531
LQ T + E K+ + Q EE+ +Q LVV+ DN
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439
Query: 532 HLTIRNLQKKVER----LQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSR 587
+ NL+KK + L +E N E A+ E + K L +A+E+ +++
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1499
Query: 588 DQLE---KMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAE 644
++LE KM + + L+S K ++ HE +++K +E + ++++ L+ L+ E
Sbjct: 1500 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1559
Query: 645 KREKQLADFREVVSQMLGLNVTSLALPDYEIIKCLERLVHSHQ 687
+ +L + + ++ + + E + L+R +H ++
Sbjct: 1560 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602
Score = 103 bits (258), Expect = 4e-22
Identities = 164/729 (22%), Positives = 298/729 (40%), Gaps = 131/729 (17%)
Query: 17 APEETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVS 76
A EE + L + + L+ + + ++LA L A+ E++ + K+ E
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL---EAQ 1260
Query: 77 CQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQEL 136
QEL+++ + A L D+V +L+ E +++ E A K+ L
Sbjct: 1261 VQELQSKCSDGERARAE-------LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 137 KKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPD---ERNDKASDEDL 193
++ + E LQ E K VS R+ EE L+D LD + ++N + L
Sbjct: 1314 SSQLQDTQELLQ----EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369
Query: 194 ILKLRDLRKENEFVKGQIVILEETIN---------VHEMEAKAS-----RETIMRLASEV 239
++L D +K+ + + LEE + E KA+ +T RL E+
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429
Query: 240 NR------EQKKAASCTEEKEKLNQDLLS------------------------------- 262
+ Q++ S E+K++ LL+
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1489
Query: 263 -----AVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVT 317
A+EAKE LER K+ L A + +SK +V K+ ELEKS +A + +
Sbjct: 1490 RALEEALEAKEELERTNKM----LKAEMEDLVSSKDDVG---KNVHELEKSKRALETQME 1542
Query: 318 TSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELV 377
++Q +++ A +L + + + + R++ +R+E + QL+ Q+ E
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602
Query: 378 EQLGKESGFHQKALQRAQK-----------------------AENMLETLQGQLTHLEAE 414
+L E Q+AL A K A L LQ Q+ + E
Sbjct: 1603 TELEDER--KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660
Query: 415 LVSGGVLRDNLNF---EKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRL 471
L RD + E +K K L+ +++ D AAE R L + E L
Sbjct: 1661 LEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA---RKQADLEKEELAEEL 1717
Query: 472 ES-----NAVIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEE-KQARTALV 525
S NA+ + K L+ ++ +E LE ++ +M + ++ + ++ +Q L
Sbjct: 1718 ASSLSGRNALQDEK---RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774
Query: 526 VERDNAHLTIRNLQKKVERLQKELNT-CRDLHTELKAKLADTN---ELKIKTLEQTKAIE 581
ER A + ++++ER KEL + ++ +K+K T E KI LE+ +E
Sbjct: 1775 TERSTAQKN-ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ--VE 1831
Query: 582 DLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLE 641
+ + K ++ +KKL + +++ A++ KE+A E + +K LK+ LE
Sbjct: 1832 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA----EKGNARVKQLKRQLE 1887
Query: 642 EAEKREKQL 650
EAE+ +++
Sbjct: 1888 EAEEESQRI 1896
Score = 91.3 bits (225), Expect = 3e-18
Identities = 139/694 (20%), Positives = 288/694 (41%), Gaps = 103/694 (14%)
Query: 24 HLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAE 83
+L+E + L +N ++ SEL L K E ++ EL+ L+ K L+ +
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK----------LEGD 1063
Query: 84 MESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITA-HAAIKENQELKKKVVE 142
+ E A + + L+ ++ + EEE A + +++ EI + A+K+ +EL+ + +
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQLAKKEEELQA-ALARLDDEIAQKNNALKKIRELEGHISD 1122
Query: 143 LNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRK 202
L E L + +KQ + E T+L D LD A+ ++L K +
Sbjct: 1123 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD-----STATQQELRAK-----R 1172
Query: 203 ENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNR--EQKKAASCTEEK-----EK 255
E E + + EET + HE + + R+ + E+ EQ K A +K EK
Sbjct: 1173 EQEVTVLKKALDEETRS-HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK 1231
Query: 256 LNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDA 315
N DL + ++EV+ +++L A Q + + S +++ +EL + Q+
Sbjct: 1232 ENADLAGELRVLGQAKQEVEHKKKKLEAQVQ---ELQSKCSDGERARAELNDKVHKLQNE 1288
Query: 316 VTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISE 375
V + K L + S++ +DT E ++E ++ + + QLE + +
Sbjct: 1289 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDT-QELLQEETRQKLNVSTKLRQLEEERNS 1347
Query: 376 LVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKF 435
L +QL +E ++ Q E + TL QL+ + +L + L K+++ K
Sbjct: 1348 LQDQLDEE-------MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 436 LDQLSQK-------------------MKLDQMAAELGFDMRLDVVLARTEQLVRLESNAV 476
++ L+Q+ +LD + +L +L ++ E+ R +
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL---VSNLEKKQRKFDQLL 1457
Query: 477 IENKTIAHNL---QRKLKTQKERLESKELHMSLLRQKIAQLEEE--------KQARTALV 525
E K I+ + + + + E+K L ++ ++ + +EE K LV
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517
Query: 526 VERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIE---- 581
+D+ + L+K L+ ++ + EL+ +L T + K++ +A++
Sbjct: 1518 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1577
Query: 582 -DLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHE------------------------AK 616
DL +Q E+ + + +++L ++EL+ + A
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637
Query: 617 ENKERARNMIEVVTSEMKTLKKSLEEAEKREKQL 650
+ +E A + + ++MK ++ LE+A ++
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Score = 88.2 bits (217), Expect = 2e-17
Identities = 132/638 (20%), Positives = 264/638 (41%), Gaps = 78/638 (12%)
Query: 32 REQLNHYRNVAQNARSELAATLVKFECAQSELQDLRS---------KMLSKEVS--CQEL 80
++QL+ QN ++ ++ ++ +LQD S K KE+ Q+
Sbjct: 1349 QDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1408
Query: 81 KAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKV 140
+ + +Y + K+ L L D V +L+ + +S + + + + E + + K
Sbjct: 1409 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE-KKQRKFDQLLAEEKNISSKY 1467
Query: 141 VELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDL 200
+ ++ + ++E E ++ R EE L + ++ L+ + KA EDL+ D+
Sbjct: 1468 ADERDRAEAEAREKETKALSLA---RALEEAL-EAKEELERTNKMLKAEMEDLVSSKDDV 1523
Query: 201 RKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDL 260
K NVHE+E K+ R A E E+ K + E+L +L
Sbjct: 1524 GK----------------NVHELE-KSKR------ALETQMEEMKT-----QLEELEDEL 1555
Query: 261 LSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQ 320
+ +AK LE ++ + + Q D +E +L++ L + + +
Sbjct: 1556 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEE------KRRQLQRQLHEYETELEDER 1609
Query: 321 SQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQL 380
Q +AA + +L G +D L+ + REE+ + + +L+AQ+ + +L
Sbjct: 1610 KQ-----RALAAAAKKKLE--GDLKDLELQADSAIKGREEA-IKQLRKLQAQMKDFQREL 1661
Query: 381 GKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFL-DQL 439
+ A++ E ++L+ L L+ +L + R + EK++ + L L
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721
Query: 440 SQKMKLDQMAAELGFDM-RLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLE 498
S + L L + +L+ L + + S+ V + A L +L T++ +
Sbjct: 1722 SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1781
Query: 499 SKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTE 558
E L ++ +L + V + + TI L+ K+ +L+++ + E
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAVKSKFKS--TIAALEAKIAQLEEQ------VEQE 1833
Query: 559 LKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKEN 618
+ K A T LK K + + + + R E+ KE+AEK VK +L EA+E
Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK-QLKRQLEEAEEE 1892
Query: 619 KERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREV 656
+R + + + L++ L+EA + + + REV
Sbjct: 1893 SQR-------INANRRKLQRELDEATESNEAMG--REV 1921
Score = 83.2 bits (204), Expect = 8e-16
Identities = 122/574 (21%), Positives = 230/574 (40%), Gaps = 36/574 (6%)
Query: 15 SPAPEETYDHLSEVPVTREQLNHYRNVAQNARS---ELAATLVKFECA----QSELQDLR 67
S + ++ D S V E ++ +N E AA K E Q EL DL
Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1433
Query: 68 SKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAH 127
+ ++ L+ + + + A + ++ + D E E+ T +
Sbjct: 1434 VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1493
Query: 128 AAIKENQELKKKVVELNEKLQKCSKENEE---NKKQVSKNCRKHEEFLTQLRDCLDPDER 184
A++ +EL++ L +++ ++ N ++ K+ R E + +++ L+ E
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1553
Query: 185 NDKASDEDLILKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMR----LASEVN 240
+A+++ KLR L + +KGQ E + + + + R + R +E+
Sbjct: 1554 ELQATED---AKLR-LEVNMQALKGQF---ERDLQARDEQNEEKRRQLQRQLHEYETELE 1606
Query: 241 REQKKAASCTEEKEKLNQDLLSA-VEAKEALE-REVKIFQERLLAGQQVWDASKQEVSLL 298
E+K+ A K+KL DL ++A A++ RE I Q R L Q ++E+
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM--KDFQRELEDA 1664
Query: 299 KKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSR 358
+ S E+ + K ++ + ++ +E +AA R R E+ E + R
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR 1724
Query: 359 EESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSG 418
+D +LEA+I++L E+L +E G + R +KA E L +L +
Sbjct: 1725 NALQDEK-RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783
Query: 419 GVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIE 478
R L E+Q +L K+ + A + F + + A+ QL E
Sbjct: 1784 ESARQQL--ERQN-----KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1836
Query: 479 NKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNL 538
+ +L++K K KE L E + Q Q E+ L + + A + +
Sbjct: 1837 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1896
Query: 539 QKKVERLQKELNTCRDLHTELKAKLADTNELKIK 572
+LQ+EL+ + + +A + N LK K
Sbjct: 1897 NANRRKLQRELDEATESN---EAMGREVNALKSK 1927
Score = 60.8 bits (146), Expect = 4e-09
Identities = 67/314 (21%), Positives = 140/314 (44%), Gaps = 64/314 (20%)
Query: 372 QISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQK 431
Q++ E++ + QK +R QKAEN L+ L+ + + L E +L++ L E +
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK---NLLQEQLQAETEL 902
Query: 432 YLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLK 491
Y + +++M+ V LA +Q E + I H ++ +L+
Sbjct: 903 YAE-----AEEMR---------------VRLAAKKQ----------ELEEILHEMEARLE 932
Query: 492 TQKERLESKELHMSLLRQKIA----QLEEEKQARTALVVERDNAHLTIRNLQKKV----- 542
+++R + + + Q++ QLEEE+ AR L +E+ A I+ L+ ++
Sbjct: 933 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992
Query: 543 --ERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTK------------AIEDLNKSRD 588
+L KE + ++L LA+ E K K L + K ++ KSR
Sbjct: 993 QNNKLSKERKLLEERISDLTTNLAEEEE-KAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1051
Query: 589 QLEKMKEKAE-------KKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLE 641
+LEK+K K E +++ +++++ + + + +E + + + E+ +L+
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1111
Query: 642 EAEKREKQLADFRE 655
+ + E ++D +E
Sbjct: 1112 KIRELEGHISDLQE 1125
Score = 55.8 bits (133), Expect = 1e-07
Identities = 51/243 (20%), Positives = 109/243 (44%), Gaps = 17/243 (6%)
Query: 39 RNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLL 98
R A + ELA L ++ LQD + ++ E +L+ E+E + N +
Sbjct: 1703 RKQADLEKEELAEELASSLSGRNALQDEKRRL---EARIAQLEEELEEEQGN-------M 1752
Query: 99 TSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVELNEKLQKCSKENEENK 158
++ DRV++ +++ LS TA Q+L+++ EL KL + K
Sbjct: 1753 EAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV---K 1809
Query: 159 KQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRKENEFVKGQIVILEETI 218
+ E + QL + ++ + R +A+ + L K + L++ V+ + + E+
Sbjct: 1810 SKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ-- 1867
Query: 219 NVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLLSAVEAKEALEREVKIFQ 278
++ +A+ + +L ++ ++++ + KL ++L A E+ EA+ REV +
Sbjct: 1868 --YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1925
Query: 279 ERL 281
+L
Sbjct: 1926 SKL 1928
Score = 37.0 bits (84), Expect = 0.064
Identities = 25/108 (23%), Positives = 52/108 (48%), Gaps = 8/108 (7%)
Query: 41 VAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTS 100
V Q AR + AAT L+ K+ + ++ + E YKE + ++ +
Sbjct: 1830 VEQEAREKQAAT--------KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1881
Query: 101 LRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVELNEKLQ 148
L+ +++E EEES ++ ++ + + A + N+ + ++V L KL+
Sbjct: 1882 LKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 32.3 bits (72), Expect = 1.6
Identities = 41/162 (25%), Positives = 77/162 (47%), Gaps = 27/162 (16%)
Query: 516 EEKQARTALVVERDN--AHLTIRNLQ-----------KKVERLQKELNTCRDLHTELKAK 562
+ +Q TA+ V + N A+L +RN Q +V R ++E+ D + K +
Sbjct: 808 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 867
Query: 563 LADT-NELKIKTLEQTKAIEDLNKSRDQLEKMKE---KAEK---KLMSVKSELDTTEHE- 614
NELK + ++ E+ N ++QL+ E +AE+ +L + K EL+ HE
Sbjct: 868 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 927
Query: 615 ---AKENKERARNM---IEVVTSEMKTLKKSLEEAEKREKQL 650
+E ++R + + + + +M L++ LEE E ++L
Sbjct: 928 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL 969
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 110 bits (276), Expect = 3e-24
Identities = 165/719 (22%), Positives = 302/719 (42%), Gaps = 121/719 (16%)
Query: 17 APEETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVS 76
A EE + L + + L + + ELA + + ++E + R K+ +
Sbjct: 1204 ALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKL---DAQ 1260
Query: 77 CQELKAEM---ESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKEN 133
QEL A++ + + A K+S L + D V L EE+ + + + +++
Sbjct: 1261 VQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDT 1320
Query: 134 QEL-----------KKKVVELNEK---LQKCSKENEENKKQVSKNCRKHEEFLTQLRDCL 179
QEL ++ +L E+ LQ+ +E EE +K + K + L + +
Sbjct: 1321 QELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKV 1380
Query: 180 DPDERNDKASDEDLILKLRDLRKENEFVKGQIVI---LEETINVHEMEAK---ASRETIM 233
D D ++ +E L+D ++ ++ + + LE+T N + E +
Sbjct: 1381 DDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQR 1440
Query: 234 RLASEVNREQKK-----------AASCTEEKEK--------------LNQDLLSAVEAKE 268
++AS + ++QKK +A EE+++ L + L A+EAKE
Sbjct: 1441 QVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKE 1500
Query: 269 ALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFRE 328
ER+ K +L A + +SK +V K+ ELEKS +A + V ++Q +
Sbjct: 1501 EFERQNK----QLRADMEDLMSSKDDVG---KNVHELEKSKRALEQQVEEMRTQLEELED 1553
Query: 329 KIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQ 388
++ A +L + + + + R++ +R+E + L Q+ EL +L E Q
Sbjct: 1554 ELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDER--KQ 1611
Query: 389 KALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDN-------LNFEKQKYLKFLDQL-- 439
+AL A K + ++ L LEA++ + RD L + + Y + L++
Sbjct: 1612 RALAVASKKKMEID-----LKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARA 1666
Query: 440 ----------SQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRK 489
+ KL + AE+ ++L LA +E R +A E +A +
Sbjct: 1667 SRDEIFAQSKESEKKLKSLEAEI---LQLQEELASSE---RARRHAEQERDELADEITNS 1720
Query: 490 LKTQKERLESKELHMSLLRQKIAQLEEEKQA-------------RTALVVERDNAHLTIR 536
+ L+ K L +IAQLEEE + +T L V+ NA L
Sbjct: 1721 ASGKSALLDEKRR----LEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAE 1776
Query: 537 --------NLQKKVERLQKELNT-CRDLHTELKAKLADT-NELKIKTLEQTKAIEDLNKS 586
N ++++ER KEL ++L +K+K T + L+ K + + +E K
Sbjct: 1777 RSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKE 1836
Query: 587 RDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEK 645
R K+ + EKKL + +++ A + KE+ +E + MK LK+ LEEAE+
Sbjct: 1837 RAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQ----MEKANARMKQLKRQLEEAEE 1891
Score = 110 bits (275), Expect = 5e-24
Identities = 152/654 (23%), Positives = 290/654 (44%), Gaps = 120/654 (18%)
Query: 61 SELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTS--------LRDRVQELEEES 112
+E +++R+++ +K+ +E+ ++ES E ++ +L + ++D ++L+EE
Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEE 963
Query: 113 AALSTSKIRTEITAHAAIKENQE-------------LKKKVVELNEKLQKCSK---ENEE 156
A ++ ++TA A IK+ +E +KK++E +++ +CS E EE
Sbjct: 964 GARQKLQLE-KVTAEAKIKKMEEEILLLEDQNSKFIKEKKLME--DRIAECSSQLAEEEE 1020
Query: 157 NKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDE----------DLILKLRDLRKENEF 206
K ++K K E ++ L + L +E+ + ++ DL ++ +L+ + +
Sbjct: 1021 KAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDE 1080
Query: 207 VKGQIVILEETIN----------VHEMEA-KASRETIMRLAS-EVNREQKKAASCTEEKE 254
+K Q+ EE + +H+ A K RE ++A + + E +KA+ EK+
Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ 1140
Query: 255 KLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQD 314
K +DL E EAL+ E++ + A Q++ +QEV+ LKK+ E K+ +A
Sbjct: 1141 K--RDLS---EELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEA--- 1192
Query: 315 AVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQIS 374
Q R++ A L E+ + E R + LE
Sbjct: 1193 -------QIQDMRQRHATALE------------------ELSEQLEQAKRFKANLEKNKQ 1227
Query: 375 ELVEQLGKESGFHQKALQRAQ-KAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYL 433
L E KE K LQ+ + ++E+ + L Q+ L A++ G LR L + K
Sbjct: 1228 GL-ETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ 1286
Query: 434 KFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQ 493
LD +S + + A + G D A +L+ +L+
Sbjct: 1287 NELDNVSTLL---EEAEKKGIKFAKD-----------------------AASLESQLQDT 1320
Query: 494 KERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQKKVERLQKELNTCR 553
+E L+ + L +I QLEEEK + E + A +NL+K+V LQ +L +
Sbjct: 1321 QELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEAR---KNLEKQVLALQSQLADTK 1377
Query: 554 DLHTELKAKLADTNELKIKTLEQTKAI----EDLNKSRDQLEKMKEKAEKKLMSVKSELD 609
+ + E K K L+ +A+ E+ + D+LEK K + +++L + +LD
Sbjct: 1378 KKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLD 1437
Query: 610 TTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREVVSQMLGL 663
+ + N E+ + + + +E K++ S AE+R++ A+ RE ++ L L
Sbjct: 1438 -HQRQVASNLEKKQKKFDQLLAEEKSI--SARYAEERDRAEAEAREKETKALSL 1488
Score = 91.7 bits (226), Expect = 2e-18
Identities = 158/724 (21%), Positives = 291/724 (40%), Gaps = 110/724 (15%)
Query: 20 ETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQE 79
E L+E + L RN + S+L L K E + EL+ + K+ + Q+
Sbjct: 1010 ECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQD 1069
Query: 80 LKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKK 139
AE++ A+ L L + +EL+ AL+ T + + A+K +EL+ +
Sbjct: 1070 QIAELQ------AQIDELKLQLAKKEEELQ---GALARGDDET-LHKNNALKVVRELQAQ 1119
Query: 140 VVELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRD 199
+ EL E + + +KQ + E T+L D LD A+ ++L K
Sbjct: 1120 IAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTT-----AAQQELRTK--- 1171
Query: 200 LRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNR--EQKKAASCTEEKEKL- 256
+E E + + + EET N HE + + R+ E++ EQ K EK K
Sbjct: 1172 --REQEVAELKKALEEETKN-HEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQG 1228
Query: 257 ----NQDLLSAVEAKEALEREVKIFQERLLAGQQ-----VWDASKQEVSLLKKSS---SE 304
N++L V+ + ++ E + +++L A Q V + + V L +K+S +E
Sbjct: 1229 LETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNE 1288
Query: 305 LE-----------KSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIR 353
L+ K +K ++DA + +SQ +E + R +L+++ EK
Sbjct: 1289 LDNVSTLLEEAEKKGIKFAKDAASL-ESQLQDTQELLQEETRQKLNLSSRIRQLEEEK-N 1346
Query: 354 EMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEA 413
+ ++E + LE Q+ L QL L + E + L L
Sbjct: 1347 SLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQ 1406
Query: 414 ELVSGGVLRDNLNFEKQKYLKFLDQLS---------------QKMKLDQMAAELGFDMRL 458
L + D L K + + LD L+ ++ K DQ+ AE
Sbjct: 1407 RLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAE-----EK 1461
Query: 459 DVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEK 518
+ E+ R E+ A E +T A +L R L+ E LE+KE +Q A +E+
Sbjct: 1462 SISARYAEERDRAEAEAR-EKETKALSLARALE---EALEAKEEFERQNKQLRADMED-- 1515
Query: 519 QARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTK 578
L+ +D+ + L+K L++++ R EL+ +L T + K++ +
Sbjct: 1516 -----LMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQ 1570
Query: 579 AIE-----DLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHE------------------- 614
A++ DL +Q E+ K K++ +++EL+ +
Sbjct: 1571 AMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLE 1630
Query: 615 -----AKENKERARNMIEVVTSEMKTLKKSLEEAE-KREKQLADFREVVSQMLGLNVTSL 668
A + ++ + + ++MK ++ LEEA R++ A +E ++ L L
Sbjct: 1631 AQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEIL 1690
Query: 669 ALPD 672
L +
Sbjct: 1691 QLQE 1694
Score = 88.2 bits (217), Expect = 2e-17
Identities = 128/605 (21%), Positives = 251/605 (41%), Gaps = 69/605 (11%)
Query: 73 KEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTS-KIRTEITAHAAIK 131
+E Q E+ KE + L + + Q+L EE L+ + TE+ A A +
Sbjct: 850 QEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAE-E 908
Query: 132 ENQELKKKVVELNEKLQKCSK--ENEENKKQVSKNCRKH-EEFLTQLRDCLDPDERNDKA 188
L K EL E L E EE + Q+ +N +K + + L + LD +E +
Sbjct: 909 MRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQK 968
Query: 189 SDEDLILKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAAS 248
+ + ++K E +I++LE+ + E K + I +S++ E++KA +
Sbjct: 969 LQLEKVTAEAKIKKMEE----EILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKN 1024
Query: 249 CTEEKEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKS 308
+ + K Q+++ + + +E L++E K QE L+K+ +L+
Sbjct: 1025 LAKIRNK--QEVMIS-DLEERLKKEEKTRQE------------------LEKAKRKLDGE 1063
Query: 309 LKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQ 368
QD + Q+Q + ++A +D L K + ++V +
Sbjct: 1064 TTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNAL--------KVVRE 1115
Query: 369 LEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFE 428
L+AQI+EL E E KA ++ + LE L+ +L + LR E
Sbjct: 1116 LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQE 1175
Query: 429 KQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQR 488
+ K L++ ++ + L+ + + EQ R ++N + +NK +
Sbjct: 1176 VAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKAN-LEKNKQGLETDNK 1234
Query: 489 KLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQKKVERLQKE 548
+L + + L+ + R+K L+ + Q A V E D + L +K +LQ E
Sbjct: 1235 ELACEVKVLQQVKAESEHKRKK---LDAQVQELHAKVSEGDRLRV---ELAEKASKLQNE 1288
Query: 549 LNTCRDLHTE--------------LKAKLADTNEL-------KIKTLEQTKAIEDLNKSR 587
L+ L E L+++L DT EL K+ + + +E+ S
Sbjct: 1289 LDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSL 1348
Query: 588 DQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKRE 647
+ ++ +E+A K L + ++ + + + K++ + + + S + KK L++AE
Sbjct: 1349 QEQQEEEEEARKNL---EKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405
Query: 648 KQLAD 652
++L +
Sbjct: 1406 QRLEE 1410
Score = 36.2 bits (82), Expect = 0.11
Identities = 18/114 (15%), Positives = 56/114 (49%)
Query: 533 LTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEK 592
L + +++++ +EL ++ T+++ +L + + LE+ + + ++ +L
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904
Query: 593 MKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKR 646
E+ +L + K EL+ H+ + E +++ +E K ++ +++ E++
Sbjct: 905 EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ 958
Score = 33.9 bits (76), Expect = 0.54
Identities = 19/85 (22%), Positives = 45/85 (52%), Gaps = 2/85 (2%)
Query: 67 RSKMLSKEVSCQ--ELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEI 124
R++ KE+ Q + + + YKE + ++ + L+ +++E EEE+ + S+ + +
Sbjct: 1846 RTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQR 1905
Query: 125 TAHAAIKENQELKKKVVELNEKLQK 149
A + N+ L ++V L +L++
Sbjct: 1906 ELDDATEANEGLSREVSTLKNRLRR 1930
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 105 bits (261), Expect = 2e-22
Identities = 158/717 (22%), Positives = 312/717 (43%), Gaps = 90/717 (12%)
Query: 20 ETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSE----LQDLRSKML---- 71
E D +++ R++L + + EL ++ + Q E L D RS +
Sbjct: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDE 311
Query: 72 -----SKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEIT- 125
K V +L++E+ YKE + + + RV+EL+E++ L +K E
Sbjct: 312 LDALREKAVRVDKLESEVSRYKE----RLHDIEFYKARVEELKEDNQVLLETKTMLEDQL 367
Query: 126 --AHAAIKENQELKKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDE 183
A + EL+K+ ++L KL E + ++K++ + E ++ DE
Sbjct: 368 EGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEE--LMEENMTLEMAQKQSMDE 425
Query: 184 RNDKASDEDLILKLRDLRKENEFVKGQIV--ILEETINVHEMEAKASRETIMRLASEVNR 241
+ + I + +L + + G V + + EME ++ +T+ L + V+
Sbjct: 426 SLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDS 485
Query: 242 EQKKAASCTEEKEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKS 301
+ A+ + EK NQ L VE LE E+ ++ L Q + SK L K
Sbjct: 486 VEGNASKILK-MEKENQRLSKKVEI---LENEIVQEKQSL---QNCQNLSKD----LMKE 534
Query: 302 SSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREES 361
++LEK+++ ++ S+ Q ++ L + S+ ++ + ++++++ +
Sbjct: 535 KAQLEKTIETLRE---NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI 591
Query: 362 RDRMVSQLEAQISELV---EQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSG 418
+ + +++S++ Q+ KE +++ +RA++ EN L L+ E EL+
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEK-----ENELLQK 646
Query: 419 GVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIE 478
+ + EK ++ L+Q + +++ + + D ++ + E L + S E
Sbjct: 647 KITNLKITCEK---IEALEQENSELERENRKLKKTLDSFKNLTF-QLESLEKENSQLDEE 702
Query: 479 NKTIAHNLQR----KLKTQKERLESKELH---------MSLLRQKIAQLEEEKQARTALV 525
N + N++ +K + +LE+KEL + LL+ + E + + L
Sbjct: 703 NLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLD 762
Query: 526 VERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKI--KTLEQT-KAIED 582
+E T+ N KK+++L+ EL +DL E + + ELKI K LEQ K +
Sbjct: 763 IENQRLQKTLENSNKKIQQLESEL---QDLEMENQTLQKNLEELKISSKRLEQLEKENKS 819
Query: 583 LNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKS--- 639
L + QLEK K++ EK+ ++ + + + +EN + N+ E KTL K
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNL----EKENKTLSKEIGI 875
Query: 640 -------LEEAEKREKQLA-----DFREVVSQMLGLNVTSLALPDYEIIKCLERLVH 684
L+E EK K+L D + +V+ L ++ S L ++ LE+L H
Sbjct: 876 YKESCVRLKELEKENKELVKRATIDIKTLVT--LREDLVSEKLKTQQMNNDLEKLTH 930
Score = 93.2 bits (230), Expect = 8e-19
Identities = 148/699 (21%), Positives = 288/699 (41%), Gaps = 72/699 (10%)
Query: 19 EETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQ 78
++T D + E L + EL + +CA ++ L+ + E +
Sbjct: 676 KKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKE 735
Query: 79 ELKAEMESYKENNARKSSLLTSLR--DRVQELEEESAALSTSKI-RTEITAHAAIKENQE 135
+LK +E K + + L S + D + +++ S KI + E ENQ
Sbjct: 736 QLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQT 795
Query: 136 LKKKVVELN------EKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKAS 189
L+K + EL E+L+K +K E+ Q+ K+ ++ E+ +LR E D
Sbjct: 796 LQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR---QQAEIKDTTL 852
Query: 190 DEDLILKLRDLRKENEFVKGQIVILEET-INVHEMEAKASRETIMRLASEVNREQKKAAS 248
+E+ + K+ +L KEN+ + +I I +E+ + + E+E K ++E + R ++
Sbjct: 853 EENNV-KIGNLEKENKTLSKEIGIYKESCVRLKELE-KENKELVKRATIDIKTLVTLRED 910
Query: 249 CTEEK---EKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSEL 305
EK +++N DL E ++ + +ERLL +Q D S+ ++ L K S L
Sbjct: 911 LVSEKLKTQQMNNDLEKLTHELE----KIGLNKERLLHDEQSTDDSRYKL-LESKLESTL 965
Query: 306 EKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRM 365
+KSL+ + EKIAA L RL + + + ++++ + E+ +
Sbjct: 966 KKSLEIKE--------------EKIAA-LEARLEESTNYNQQLRQELKTVKKNYEALKQR 1010
Query: 366 VSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNL 425
+ +V+ SG K + +Q+ L ++ +L +E L
Sbjct: 1011 QDE-----ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERN-------NATL 1058
Query: 426 NFEKQKYLKFLDQL--------SQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVI 477
EKQ L QL +Q + L + L + L +++E++ +
Sbjct: 1059 QAEKQALKTQLKQLETQNNNLQAQILALQRQTVSL---QEQNTTLQTQNAKLQVENSTLN 1115
Query: 478 ENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRN 537
T N +L Q+ LE++ I + E+ K +L+ + + L
Sbjct: 1116 SQSTSLMNQNAQLLIQQSSLENEN------ESVIKEREDLKSLYDSLIKDHEKLELLHER 1169
Query: 538 LQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKS-RDQLEKM--K 594
+ E L + T + H L+ + D + + L+Q +EDL K + + EKM +
Sbjct: 1170 QASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLE 1229
Query: 595 EKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQL-ADF 653
K + + + +L + EV+ ++ K LK L ++ + +L A+F
Sbjct: 1230 NKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEF 1289
Query: 654 REVVSQMLGLNVTSLALPDY-EIIKCLERLVHSHQHHFV 691
++ Q L++TS L + E++ L+ + H +
Sbjct: 1290 SKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLL 1328
Score = 71.6 bits (174), Expect = 2e-12
Identities = 142/673 (21%), Positives = 284/673 (42%), Gaps = 85/673 (12%)
Query: 43 QNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAE---MESYKENNARKSSLLT 99
Q + L + K + +SELQDL + + + + +ELK +E ++ N +
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETS 825
Query: 100 SLRDRVQELEEESAAL-------STSKIRTEITAHAAIKENQELKKKVVELNEKLQKCSK 152
L ++LE+E+ L T+ + KEN+ L K++ E + K
Sbjct: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRL-K 884
Query: 153 ENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRKENEFVKGQIV 212
E E+ K++ K + L LR+ L ++ + + DL +L K K +++
Sbjct: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIG-LNKERLL 943
Query: 213 ILEETINVHEMEAKASR-ETIMRLASEVNREQKKAASC-----TEEKEKLNQDLLSAVEA 266
E++ + + S+ E+ ++ + E+ E+ A T ++L Q+L + +
Sbjct: 944 HDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKN 1003
Query: 267 KEALEREVKIFQERLLAGQ-------QVWDASKQEVS--LLKKSSSELE-----KSLKAS 312
EAL++ +ER++ W+ QE + LLK +E +L+A
Sbjct: 1004 YEALKQRQD--EERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAE 1061
Query: 313 QDAVTTS----QSQYFSFREKIAALLRGRLSMT--GSTEDTILEKIREMDSREESRDRMV 366
+ A+ T ++Q + + +I AL R +S+ +T T K++ +S S+ +
Sbjct: 1062 KQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSL 1121
Query: 367 SQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETL-----------QGQLTHLEAEL 415
AQ+ L++Q E+ ++ ++ + +++ ++L + Q + E+ +
Sbjct: 1122 MNQNAQL--LIQQSSLENE-NESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLI 1178
Query: 416 VSGGVLRD---NLNFEKQKYLKFLDQL-SQKMKLDQMAAELGFDMRLDVVLARTEQLVRL 471
G L+ NL E + +QL QK +L+ + L + ++ + + V
Sbjct: 1179 SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA 1238
Query: 472 ESNAVI-ENKTIAHN----------LQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQA 520
E + EN + H LQ K K L + +L + L + ++L+E+ Q
Sbjct: 1239 EYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQ 1298
Query: 521 RTALVVERDNAHLTIRNLQKKVERLQKEL-NTCRDLHTELKAKLADTNELK-IKTLEQTK 578
+ +N + L+ +E + L + + L + + L E K + +EQ +
Sbjct: 1299 LDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQ 1358
Query: 579 AIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKK 638
I+ LN+ R Q KEK E+K+M D + + N +T +M+ L K
Sbjct: 1359 YIDKLNELRRQ----KEKLEEKIMDQYKFYDPSPPRRRGN---------WITLKMRKLIK 1405
Query: 639 SLEEAEK-REKQL 650
S ++ + R+K L
Sbjct: 1406 SKKDINRERQKSL 1418
Score = 48.1 bits (113), Expect = 3e-05
Identities = 81/430 (18%), Positives = 173/430 (40%), Gaps = 38/430 (8%)
Query: 27 EVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMES 86
++ +L N Q R EL +E + + R S +S ++ K E ES
Sbjct: 975 KIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERES 1034
Query: 87 YKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVELNEK 146
+ L ++DR+ E+E +A L K + +N L+ +++ L +
Sbjct: 1035 QETTRE-----LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1089
Query: 147 LQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPD-----ERNDKASDEDLILKLRDLR 201
++N + Q +K ++ +Q ++ + +++ ++ + ++K R+
Sbjct: 1090 TVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDL 1149
Query: 202 KE--NEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQD 259
K + +K E+ +HE +A I + + + + + +++ NQ
Sbjct: 1150 KSLYDSLIKDH----EKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ- 1204
Query: 260 LLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTS 319
LL E LE+ +K+ QE++L + + E K L D + +
Sbjct: 1205 LLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEY-----------KKLCGENDRLNHT 1253
Query: 320 QSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQ 379
SQ E + + S+ +++ LE+ R +++ QL+ ++L Q
Sbjct: 1254 YSQLLKETEVLQTDHKNLKSLLNNSK---LEQTR-LEAEFSKLKEQYQQLDITSTKLNNQ 1309
Query: 380 LGKESGFHQKALQRAQKAENMLETLQGQ-LTHLEAELVSGGVLRDNLNFEKQKYLKFLDQ 438
S + + + ++TL Q T LE + S +D + E+++Y+ L++
Sbjct: 1310 CELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMES----KDLFHVEQRQYIDKLNE 1365
Query: 439 L-SQKMKLDQ 447
L QK KL++
Sbjct: 1366 LRRQKEKLEE 1375
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 105 bits (261), Expect = 2e-22
Identities = 158/717 (22%), Positives = 312/717 (43%), Gaps = 90/717 (12%)
Query: 20 ETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSE----LQDLRSKML---- 71
E D +++ R++L + + EL ++ + Q E L D RS +
Sbjct: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDE 311
Query: 72 -----SKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEIT- 125
K V +L++E+ YKE + + + RV+EL+E++ L +K E
Sbjct: 312 LDALREKAVRVDKLESEVSRYKE----RLHDIEFYKARVEELKEDNQVLLETKTMLEDQL 367
Query: 126 --AHAAIKENQELKKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDE 183
A + EL+K+ ++L KL E + ++K++ + E ++ DE
Sbjct: 368 EGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEE--LMEENMTLEMAQKQSMDE 425
Query: 184 RNDKASDEDLILKLRDLRKENEFVKGQIV--ILEETINVHEMEAKASRETIMRLASEVNR 241
+ + I + +L + + G V + + EME ++ +T+ L + V+
Sbjct: 426 SLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDS 485
Query: 242 EQKKAASCTEEKEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKS 301
+ A+ + EK NQ L VE LE E+ ++ L Q + SK L K
Sbjct: 486 VEGNASKILK-MEKENQRLSKKVEI---LENEIVQEKQSL---QNCQNLSKD----LMKE 534
Query: 302 SSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREES 361
++LEK+++ ++ S+ Q ++ L + S+ ++ + ++++++ +
Sbjct: 535 KAQLEKTIETLRE---NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI 591
Query: 362 RDRMVSQLEAQISELV---EQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSG 418
+ + +++S++ Q+ KE +++ +RA++ EN L L+ E EL+
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEK-----ENELLQK 646
Query: 419 GVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIE 478
+ + EK ++ L+Q + +++ + + D ++ + E L + S E
Sbjct: 647 KITNLKITCEK---IEALEQENSELERENRKLKKTLDSFKNLTF-QLESLEKENSQLDEE 702
Query: 479 NKTIAHNLQR----KLKTQKERLESKELH---------MSLLRQKIAQLEEEKQARTALV 525
N + N++ +K + +LE+KEL + LL+ + E + + L
Sbjct: 703 NLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLD 762
Query: 526 VERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKI--KTLEQT-KAIED 582
+E T+ N KK+++L+ EL +DL E + + ELKI K LEQ K +
Sbjct: 763 IENQRLQKTLENSNKKIQQLESEL---QDLEMENQTLQKNLEELKISSKRLEQLEKENKS 819
Query: 583 LNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKS--- 639
L + QLEK K++ EK+ ++ + + + +EN + N+ E KTL K
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNL----EKENKTLSKEIGI 875
Query: 640 -------LEEAEKREKQLA-----DFREVVSQMLGLNVTSLALPDYEIIKCLERLVH 684
L+E EK K+L D + +V+ L ++ S L ++ LE+L H
Sbjct: 876 YKESCVRLKELEKENKELVKRATIDIKTLVT--LREDLVSEKLKTQQMNNDLEKLTH 930
Score = 89.0 bits (219), Expect = 1e-17
Identities = 147/699 (21%), Positives = 284/699 (40%), Gaps = 73/699 (10%)
Query: 19 EETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQ 78
++T D + E L + EL + +CA ++ L+ + E +
Sbjct: 676 KKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKE 735
Query: 79 ELKAEMESYKENNARKSSLLTSLR--DRVQELEEESAALSTSKI-RTEITAHAAIKENQE 135
+LK +E K + + L S + D + +++ S KI + E ENQ
Sbjct: 736 QLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQT 795
Query: 136 LKKKVVELN------EKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKAS 189
L+K + EL E+L+K +K E+ Q+ K+ ++ E+ +LR E D
Sbjct: 796 LQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR---QQAEIKDTTL 852
Query: 190 DEDLILKLRDLRKENEFVKGQIVILEET-INVHEMEAKASRETIMRLASEVNREQKKAAS 248
+E+ + K+ +L KEN+ + +I I +E+ + + E+E K ++E + R ++
Sbjct: 853 EENNV-KIGNLEKENKTLSKEIGIYKESCVRLKELE-KENKELVKRATIDIKTLVTLRED 910
Query: 249 CTEEK---EKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSEL 305
EK +++N DL E ++ + +ERLL +Q D K S+L
Sbjct: 911 LVSEKLKTQQMNNDLEKLTHELE----KIGLNKERLLHDEQSTD------DRYKLLESKL 960
Query: 306 EKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRM 365
E +LK S + EKIAA L RL + + + ++++ + E+ +
Sbjct: 961 ESTLKKSLEIK----------EEKIAA-LEARLEESTNYNQQLRQELKTVKKNYEALKQR 1009
Query: 366 VSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNL 425
+ +V+ SG K + +Q+ L ++ +L +E L
Sbjct: 1010 QDE-----ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERN-------NATL 1057
Query: 426 NFEKQKYLKFLDQL--------SQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVI 477
EKQ L QL +Q + L + L + L +++E++ +
Sbjct: 1058 QAEKQALKTQLKQLETQNNNLQAQILALQRQTVSL---QEQNTTLQTQNAKLQVENSTLN 1114
Query: 478 ENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRN 537
T N +L Q+ LE++ I + E+ K +L+ + + L
Sbjct: 1115 SQSTSLMNQNAQLLIQQSSLENEN------ESVIKEREDLKSLYDSLIKDHEKLELLHER 1168
Query: 538 LQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKS-RDQLEKM--K 594
+ E L + T + H L+ + D + + L+Q +EDL K + + EKM +
Sbjct: 1169 QASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLE 1228
Query: 595 EKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQL-ADF 653
K + + + +L + EV+ ++ K LK L ++ + +L A+F
Sbjct: 1229 NKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEF 1288
Query: 654 REVVSQMLGLNVTSLALPDY-EIIKCLERLVHSHQHHFV 691
++ Q L++TS L + E++ L+ + H +
Sbjct: 1289 SKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLL 1327
Score = 73.2 bits (178), Expect = 8e-13
Identities = 141/672 (20%), Positives = 283/672 (42%), Gaps = 84/672 (12%)
Query: 43 QNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAE---MESYKENNARKSSLLT 99
Q + L + K + +SELQDL + + + + +ELK +E ++ N +
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETS 825
Query: 100 SLRDRVQELEEESAAL-------STSKIRTEITAHAAIKENQELKKKVVELNEKLQKCSK 152
L ++LE+E+ L T+ + KEN+ L K++ E + K
Sbjct: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRL-K 884
Query: 153 ENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRKENEFVKGQIV 212
E E+ K++ K + L LR+ L ++ + + DL +L K K +++
Sbjct: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIG-LNKERLL 943
Query: 213 ILEETINVHEMEAKASRETIMRLASEVNREQKKAASC-----TEEKEKLNQDLLSAVEAK 267
E++ + ++ E+ ++ + E+ E+ A T ++L Q+L + +
Sbjct: 944 HDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNY 1003
Query: 268 EALEREVKIFQERLLAGQ-------QVWDASKQEVS--LLKKSSSELE-----KSLKASQ 313
EAL++ +ER++ W+ QE + LLK +E +L+A +
Sbjct: 1004 EALKQRQD--EERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1061
Query: 314 DAVTTS----QSQYFSFREKIAALLRGRLSMT--GSTEDTILEKIREMDSREESRDRMVS 367
A+ T ++Q + + +I AL R +S+ +T T K++ +S S+ +
Sbjct: 1062 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1121
Query: 368 QLEAQISELVEQLGKESGFHQKALQRAQKAENMLETL-----------QGQLTHLEAELV 416
AQ+ L++Q E+ ++ ++ + +++ ++L + Q + E+ +
Sbjct: 1122 NQNAQL--LIQQSSLENE-NESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLIS 1178
Query: 417 SGGVLRD---NLNFEKQKYLKFLDQL-SQKMKLDQMAAELGFDMRLDVVLARTEQLVRLE 472
G L+ NL E + +QL QK +L+ + L + ++ + + V E
Sbjct: 1179 KHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAE 1238
Query: 473 SNAVI-ENKTIAHN----------LQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQAR 521
+ EN + H LQ K K L + +L + L + ++L+E+ Q
Sbjct: 1239 YKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQL 1298
Query: 522 TALVVERDNAHLTIRNLQKKVERLQKEL-NTCRDLHTELKAKLADTNELK-IKTLEQTKA 579
+ +N + L+ +E + L + + L + + L E K + +EQ +
Sbjct: 1299 DITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQY 1358
Query: 580 IEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKS 639
I+ LN+ R Q KEK E+K+M D + + N +T +M+ L KS
Sbjct: 1359 IDKLNELRRQ----KEKLEEKIMDQYKFYDPSPPRRRGN---------WITLKMRKLIKS 1405
Query: 640 LEEAEK-REKQL 650
++ + R+K L
Sbjct: 1406 KKDINRERQKSL 1417
Score = 48.1 bits (113), Expect = 3e-05
Identities = 81/430 (18%), Positives = 173/430 (40%), Gaps = 38/430 (8%)
Query: 27 EVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMES 86
++ +L N Q R EL +E + + R S +S ++ K E ES
Sbjct: 974 KIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERES 1033
Query: 87 YKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVELNEK 146
+ L ++DR+ E+E +A L K + +N L+ +++ L +
Sbjct: 1034 QETTRE-----LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1088
Query: 147 LQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPD-----ERNDKASDEDLILKLRDLR 201
++N + Q +K ++ +Q ++ + +++ ++ + ++K R+
Sbjct: 1089 TVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDL 1148
Query: 202 KE--NEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQD 259
K + +K E+ +HE +A I + + + + + +++ NQ
Sbjct: 1149 KSLYDSLIKDH----EKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ- 1203
Query: 260 LLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTS 319
LL E LE+ +K+ QE++L + + E K L D + +
Sbjct: 1204 LLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEY-----------KKLCGENDRLNHT 1252
Query: 320 QSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQ 379
SQ E + + S+ +++ LE+ R +++ QL+ ++L Q
Sbjct: 1253 YSQLLKETEVLQTDHKNLKSLLNNSK---LEQTR-LEAEFSKLKEQYQQLDITSTKLNNQ 1308
Query: 380 LGKESGFHQKALQRAQKAENMLETLQGQ-LTHLEAELVSGGVLRDNLNFEKQKYLKFLDQ 438
S + + + ++TL Q T LE + S +D + E+++Y+ L++
Sbjct: 1309 CELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMES----KDLFHVEQRQYIDKLNE 1364
Query: 439 L-SQKMKLDQ 447
L QK KL++
Sbjct: 1365 LRRQKEKLEE 1374
>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
Length = 872
Score = 105 bits (261), Expect = 2e-22
Identities = 149/664 (22%), Positives = 296/664 (44%), Gaps = 61/664 (9%)
Query: 25 LSEVPVTREQL---NHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELK 81
LSEV RE L + + ++ E + +F+ + Q+ S+ K+ ++L+
Sbjct: 166 LSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKK---EKLE 222
Query: 82 AEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVV 141
E++ + + + + + +L+ VQ+ +EE L +I A KE ++ + +
Sbjct: 223 KELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNA 282
Query: 142 ELNEKLQK----CSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKL 197
+L ++ ++ C + ++EN+++ + K EE + Q+R LD + N E + KL
Sbjct: 283 KLQQENEQHSLVCEQLSQENQQKALELKAKEEE-VHQMR--LDIGKLNKIR--EQIHKKL 337
Query: 198 R-------DLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASE---VNREQKKAA 247
++ + E +K QIV LE + + +A+ R+ + L E +N+ KA
Sbjct: 338 HHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAV 397
Query: 248 SCTEEKEKLNQDLLSAVE-AKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELE 306
+ T+++ DL+ E AK LE E++ +++ +++ ++E +S+L
Sbjct: 398 NATQKQT----DLVKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLT 453
Query: 307 KSLKASQDAVTTSQSQYFSFREKIAA----LLRGRLSMTGSTEDTILEKIREMDSREESR 362
+ + + + + ++Q F +R+KIA L + + D L +++++E
Sbjct: 454 QKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEIT 513
Query: 363 D--RMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGV 420
D R + + Q+ EL E + + K Q+ E ETL+ +L L + +
Sbjct: 514 DMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKH 573
Query: 421 LRDNLNFEKQKYLKFL-----DQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNA 475
+ E++K L+ + ++L QK +LDQ+ +E D+ ++ R ++L L
Sbjct: 574 FIEKQEAEERKLLRIIAEADGERLRQKKELDQVISER--DILGSQLVRRNDELALLYEKI 631
Query: 476 VIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQ--ARTALVVE--RDNA 531
I+ L + +RLE M +LR +I +L EK AR+ VE R
Sbjct: 632 KIQQSV----LNKGESQYNQRLED----MRILRLEIKKLRREKGILARSMANVEELRQEF 683
Query: 532 HLTIRNLQKKVER---LQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRD 588
R L K+ R L++EL ++H K + +D N ++ T ++K+ +
Sbjct: 684 FHMQRELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEE 743
Query: 589 QLEK--MKEKAEKKLMSVKSELDTTE-HEAKENKERARNMIEVVTSEMKTLKKSLEEAEK 645
+EK + ++ EK M +K L EA E + R + ++K L L E
Sbjct: 744 VVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEV 803
Query: 646 REKQ 649
+ K+
Sbjct: 804 QSKE 807
Score = 94.4 bits (233), Expect = 3e-19
Identities = 148/669 (22%), Positives = 287/669 (42%), Gaps = 107/669 (15%)
Query: 33 EQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNA 92
++L + + ++E+ A + ++ ELQ L ++ +++ + E+E ++ NA
Sbjct: 223 KELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNA 282
Query: 93 RKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKE--NQELKKKVVELNEKLQKC 150
K++ E H+ + E +QE ++K +EL
Sbjct: 283 --------------------------KLQQENEQHSLVCEQLSQENQQKALEL------- 309
Query: 151 SKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRKENEFVKGQ 210
K EE Q+ + K + Q+ L E + KA ++ + E +K Q
Sbjct: 310 -KAKEEEVHQMRLDIGKLNKIREQIHKKLHHTE-DQKA----------EVEQHKETLKNQ 357
Query: 211 IVILEETINVHEMEAKASRETIMRLASE---VNREQKKAASCTEEKEKLNQDLLSAVE-A 266
IV LE + + +A+ R+ + L E +N+ KA + T+++ DL+ E A
Sbjct: 358 IVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQ----TDLVKLHEQA 413
Query: 267 KEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSF 326
K LE E++ +++ +++ ++E +S+L + + + + + ++Q F +
Sbjct: 414 KRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDY 473
Query: 327 REKIA----ALLRGRLSMTGSTEDTILEKIREMDSREESRD--RMVSQLEAQISELVEQL 380
R+KIA L + + D L +++++E D R + + Q+ EL E +
Sbjct: 474 RKKIAESEIKLKQQQNLYEAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDI 533
Query: 381 GKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFL---- 436
+ K Q+ E ETL+ +L L + + + E++K L+ +
Sbjct: 534 SAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEAD 593
Query: 437 -DQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIE----NKTIAHNLQRKLK 491
++L QK +LDQ+ +E D+ ++ R ++L L I+ NK + QR
Sbjct: 594 GERLRQKKELDQVISER--DILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYNQRLED 651
Query: 492 TQKERLESKEL--HMSLLRQKIAQLEEEKQ----ARTALVVERDNAHLTIRNLQK--KVE 543
+ RLE K+L +L + +A +EE +Q + L+ ER L+ V
Sbjct: 652 MRILRLEIKKLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVH 711
Query: 544 RLQK-------ELNTCRDLHTELKAKLADTNELKIKTL---EQTKAIEDLN--------- 584
R +K + +HT K ++ T E+ K L E+ K +L
Sbjct: 712 RWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGP 771
Query: 585 KSRDQLEKMKEKAEKKLMSVK---SELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLE 641
++ +QL+ + K +K SEL+ E ++KE K +E +T+E++ LKK
Sbjct: 772 EAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYE----VEKLTNELQNLKKKY- 826
Query: 642 EAEKREKQL 650
A+KR++QL
Sbjct: 827 LAQKRKEQL 835
Score = 84.0 bits (206), Expect = 5e-16
Identities = 132/656 (20%), Positives = 280/656 (42%), Gaps = 78/656 (11%)
Query: 69 KMLSK-EVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAH 127
K L K + + L A M+ +N R L+ R+ E+ SA ++T
Sbjct: 34 KSLEKFRIEYERLHAVMKKSYDNEKR---LMAKCRELNAEIVVNSAKVAT---------- 80
Query: 128 AAIKENQELKKKVVELNEKLQKCSK------ENEENKKQVSKNCRKHEEFLTQLRDCLDP 181
A+K +Q+ + + L ++++K K + E+ K+ ++ LT+L +
Sbjct: 81 -ALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSG 139
Query: 182 DERNDKASDEDLILKLRDLRKENEFVKGQIVILEETI---NVHEMEAKASRE----TIMR 234
+ ++ DL+ ++ KE + + ++V L E++ + E + S+E I +
Sbjct: 140 LSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQ 199
Query: 235 LASEVNREQKKAASCTEEKEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQE 294
E+ + Q +A+ +KEKL ++L ++ + E+K Q+ + ++ +Q+
Sbjct: 200 FQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQ 259
Query: 295 VSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIRE 354
+ K + K L+ Q Q + + +L+ +LS +K E
Sbjct: 260 LKEQKILNERAAKELEQFQMRNAKLQQE-----NEQHSLVCEQLSQENQ------QKALE 308
Query: 355 MDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAE 414
+ ++EE +M + +++++ EQ+ K+ H Q+A+ E ETL+ Q+ LE E
Sbjct: 309 LKAKEEEVHQMRLDI-GKLNKIREQIHKK--LHHTEDQKAE-VEQHKETLKNQIVGLERE 364
Query: 415 LVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDM-RLDVVLART--EQLVRL 471
+ + + + L+ D L++ M A + D+ +L R ++
Sbjct: 365 VEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNY 424
Query: 472 ESNAVIENKTIAH-------------NLQRKLKTQKERLESKELHMSLLRQKIAQLEEE- 517
+ A + K I H +L +K+ E ++ +E + R+KIA+ E +
Sbjct: 425 KDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKL 484
Query: 518 KQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQT 577
KQ + R + +L +NL + + + D+ +LK + +ELK +
Sbjct: 485 KQQQNLYEAVRSDRNLYSKNLVEAQDEIT-------DMKRKLKIMIHQVDELKEDISAKE 537
Query: 578 KAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVT---SEMK 634
A+ L+ + ++EK KE + +L ++ + T+H ++ + R ++ ++ E
Sbjct: 538 SALVKLHLEQQRIEKEKETLKAELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERL 597
Query: 635 TLKKSLEEAEKREKQLADFREVVSQMLGLNVTSLALPDYEIIKCLERLVHSHQHHF 690
KK L+ Q+ R+++ L LAL YE IK + +++ + +
Sbjct: 598 RQKKELD-------QVISERDILGSQLVRRNDELALL-YEKIKIQQSVLNKGESQY 645
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 104 bits (259), Expect = 3e-22
Identities = 124/642 (19%), Positives = 281/642 (43%), Gaps = 47/642 (7%)
Query: 32 REQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENN 91
R L ++ + AQNA + L K ++L + +K+ K+ C +L++ ++ YKE
Sbjct: 662 RADLQNHLDTAQNALQDKQQELNKIT---TQLDQVTAKLQDKQEHCSQLESHLKEYKEK- 717
Query: 92 ARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVELNEKLQKCS 151
SL + +ELE + L + + + A+++ Q+ ++ +L + + S
Sbjct: 718 ------YLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELS 771
Query: 152 KENEENKKQVSK---NCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRKENEFVK 208
K+ E K+ VS + +K E L ++ L E + +D ++ + ++E +
Sbjct: 772 KQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELN 831
Query: 209 GQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQD----LLSAV 264
+I + +ME +A + + ++++ + E EK NQ +L
Sbjct: 832 NRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLE 891
Query: 265 EAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYF 324
+ + L+ ++++ E L Q+ K+ + K++S +L+ L + Q+ + +Q+
Sbjct: 892 KTCKELKHQLQVQMENTLKEQK---ELKKSLEKEKEASHQLKLELNSMQEQLIQAQNT-L 947
Query: 325 SFREKIAALLRGRLSMTGSTEDTILEKIREMDSREE----SRDRMVSQLEAQISELVEQL 380
EK L+G ++ + + ++I + + + + ++L+ Q+++ ++L
Sbjct: 948 KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQEL 1007
Query: 381 GKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLS 440
E +K++ + LQ E+EL++ +D + E++ L D +S
Sbjct: 1008 AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLA--TRQDLKSVEEKLSLAQEDLIS 1065
Query: 441 QKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESK 500
+ +Q+ + L A EQ + + E ++Q++ +++ L ++
Sbjct: 1066 NR---NQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNE 1122
Query: 501 ELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQ--KKVERLQKELNTCRDLHTE 558
+ K+A++EE K R + + N L L+ K++ L+ E
Sbjct: 1123 -------KSKLAEIEEIK-CRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLE 1174
Query: 559 LKAKLADTNELKIKTLEQTKAI--EDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAK 616
L+ K AD+ + ++ ++ + I + + K ++L+K + E KL S E + + +
Sbjct: 1175 LQGK-ADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHE 1233
Query: 617 ENKERARNMIEVVTSEMKTLKKSLEEAEKR----EKQLADFR 654
EN+ + I + + T+KK + +++R EKQ D R
Sbjct: 1234 ENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLR 1275
Score = 102 bits (254), Expect = 1e-21
Identities = 146/620 (23%), Positives = 259/620 (41%), Gaps = 49/620 (7%)
Query: 43 QNARSELAATLVKFECAQSEL-------QDLRSKMLSKEVSCQELKAEMESYKENNARKS 95
Q +S L+A+ EL Q L+ ++ E Q LKAE + ++ K
Sbjct: 347 QQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKE 406
Query: 96 SLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELK-KKVVELNEKLQKCSKEN 154
L+ + +L S L T + E AH +KE ++L +K+++ +++ +
Sbjct: 407 QHGLQLQSEINQLH--SKLLETERQLGE--AHGRLKEQRQLSSEKLMDKEQQVADLQLKL 462
Query: 155 EENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRKENEFVKGQIVIL 214
++Q+ + E QL D + +A + KLR+ + + E V QI
Sbjct: 463 SRLEEQLKEKVTNSTELQHQL-DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDK 521
Query: 215 EETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLLSAVEAKEALEREV 274
++ I E + S+E I L E K + E LNQ E L+ +V
Sbjct: 522 DQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ----LQEKNHTLQEQV 577
Query: 275 KIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALL 334
E+L + ++ KQ L E + L+A+QD V + ++ ++
Sbjct: 578 TQLTEKL---KNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQL---- 630
Query: 335 RGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRA 394
+ EK+ ++D + +++ ++ EA + L Q ALQ
Sbjct: 631 -----------NESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK 679
Query: 395 QKAENMLETLQGQLT-HLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELG 453
Q+ N + T Q+T L+ + L +L K+KYL L+Q +++ L+ +L
Sbjct: 680 QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLS-LEQKTEE--LEGQIKKLE 736
Query: 454 FDMRLDVVLARTEQLVRLESNAVIEN--KTIAHNLQRKLKTQKERLESKELHMSLLRQKI 511
D L+V ++ + L L+ + + A L ++L+ +KE + S L L++K
Sbjct: 737 ADS-LEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLD---LQKKS 792
Query: 512 AQLEEEKQARTALVVERDNAHLTIRNLQKKVERLQKELNT-CRDLHTELKAKLADTNELK 570
LE KQ T E+ L ++ + +ELN + TEL+ K+ E
Sbjct: 793 EALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQ-KVKMEKEAL 851
Query: 571 IKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVT 630
+ L K + L+K D L+ K + EK+ K+ + E KE K + + +E
Sbjct: 852 MTELSTVK--DKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTL 909
Query: 631 SEMKTLKKSLEEAEKREKQL 650
E K LKKSLE+ ++ QL
Sbjct: 910 KEQKELKKSLEKEKEASHQL 929
Score = 102 bits (254), Expect = 1e-21
Identities = 154/713 (21%), Positives = 277/713 (38%), Gaps = 94/713 (13%)
Query: 8 HIALGAASPAPEETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLR 67
H+ L A ++ + LSEV + L Q R E ++ QSE+ L
Sbjct: 364 HVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQL---QSEINQLH 420
Query: 68 SKMLSKEVSCQE----LKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTE 123
SK+L E E LK + + E K + L+ ++ LEE+ T+ +
Sbjct: 421 SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ 480
Query: 124 ITAHAAIKENQELKKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDE 183
+++QE + KL++ + E+ +Q+ +K + L+ +
Sbjct: 481 HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS 540
Query: 184 RNDKASDEDLILK----------LRDLRKENEFVKGQIVILEETI------------NVH 221
+K EDL K L L+++N ++ Q+ L E + N+H
Sbjct: 541 LLEKER-EDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLH 599
Query: 222 EM------EAKASRETIMRLASEVNR------EQKKAASCTEEKEKLNQDLLSAVEAKEA 269
+ +A+++ ++ L + VN E K+ S + + K +LL + EA +
Sbjct: 600 DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKT 659
Query: 270 LEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREK 329
+R Q L Q +QE++ + ++ L+ Q+ + +S ++EK
Sbjct: 660 AQRAD--LQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEK 717
Query: 330 IAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQ------LEAQISELVEQLGKE 383
+L + + G + + + S+E++ + Q LE + +EL +QL E
Sbjct: 718 YLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEME 777
Query: 384 SGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKM 443
QK LE+++ +LT E E KQ + + LSQ+
Sbjct: 778 KEIVSSTRLDLQKKSEALESIKQKLTKQEEE--------------KQILKQDFETLSQET 823
Query: 444 KLDQMAAELGFDMRLDVVLARTE-QLVRLESNAVI-ENKTIAHNLQR---KLKTQKERLE 498
K+ EL ++ V TE Q V++E A++ E T+ L + LK K E
Sbjct: 824 KIQH--EELNNRIQTTV----TELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFE 877
Query: 499 S----------------KELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQKKV 542
KEL L Q L+E+K+ + +L E++ +H L
Sbjct: 878 KENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQ 937
Query: 543 ERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLM 602
E+L + NT + E + + NELK + ++ K IE L K + E KL
Sbjct: 938 EQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKL- 996
Query: 603 SVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFRE 655
+ +L E KE+ + +T K+ + RE +L R+
Sbjct: 997 --QQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQ 1047
Score = 92.0 bits (227), Expect = 2e-18
Identities = 143/703 (20%), Positives = 296/703 (42%), Gaps = 68/703 (9%)
Query: 19 EETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQ 78
EE L + ++Q + ++ +EL + + E AQ+E +++ E
Sbjct: 107 EELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAA 166
Query: 79 ELKAEMESYKENNARKSSLLTSLRDRVQELEEE--SAALSTSKIRTEITAHAAIKENQEL 136
+L E+ K + SL + +V L EE A ++TE+ I++ L
Sbjct: 167 QLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVL 226
Query: 137 KKKVVELNEKLQKCSKENEENKKQVSKNCRK-------HEEFLTQLRDCL--DPDE---- 183
KK++V++ + + E E +++ C+K E ++QLR L P E
Sbjct: 227 KKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVY 286
Query: 184 ----RNDKASDEDLILKLRD-----LRKENEFVKGQIVILEETINVHEMEAKASRETI-- 232
+ K+S +L K + L+KE ++ K + EE+++ ++A ++ +
Sbjct: 287 VQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDC 346
Query: 233 ----MRLA---SEVNREQKKAASCTEEKEKLNQDLLSAVEAK-EALEREVKIFQERLLAG 284
RL+ + ++R + + E +KL ++ LS VE K + L+ E K Q++
Sbjct: 347 QQLQSRLSASETSLHRIHVELSEKGEATQKLKEE-LSEVETKYQHLKAEFKQLQQQREEK 405
Query: 285 QQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQ---SQYFSFREKIAALLRGRLS-- 339
+Q + E++ L E E+ L + + + S+ +E+ A L+ +LS
Sbjct: 406 EQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRL 465
Query: 340 -------MTGSTE-----DTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFH 387
+T STE D ++ +E + ++S + + + + +++ Q+G +
Sbjct: 466 EEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKI 525
Query: 388 QKALQRAQKAENMLETLQGQLTHLEAELVSG---GVLRDNLNFEKQKYLKFLDQLSQKMK 444
Q QK++ + L+ + L A++ +G + + L + + + QL++K+K
Sbjct: 526 QNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLK 585
Query: 445 LDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHM 504
+ + + D V + L R + V+ +T + L +L KE++ ++ +
Sbjct: 586 NQSESHKQAQENLHDQVQEQKAHL-RAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQI 644
Query: 505 SLLRQKIAQLEEEKQARTA-LVVERDNAHLTIRNLQKKVERLQKELNT-----------C 552
+ + E K A+ A L D A +++ Q+++ ++ +L+ C
Sbjct: 645 KAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHC 704
Query: 553 RDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTE 612
L + LK L+ KT E I+ L +++ KE+A + L + E
Sbjct: 705 SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLE 764
Query: 613 HEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFRE 655
A E ++ E+V+S L+K E E +++L E
Sbjct: 765 LRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEE 807
Score = 80.9 bits (198), Expect = 4e-15
Identities = 143/732 (19%), Positives = 300/732 (40%), Gaps = 95/732 (12%)
Query: 33 EQLNHYRNV-------AQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEME 85
E HY V S LA + E+QDL++ + ++ +ELK E+E
Sbjct: 55 ELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELE 114
Query: 86 SY---KENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVE 142
Y ++ A+ L+T +Q LE++ T + ++ +L ++ +
Sbjct: 115 KYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIAD 174
Query: 143 LNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRK 202
+ K + E +++V++ + + T ++D E + ED+ + ++L +
Sbjct: 175 IKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDL--KTELLQRPGIEDVAVLKKELVQ 232
Query: 203 ENEFVKGQIVILEETINVHEMEAK-------ASRETIMRLASEVNREQKKAASCTEEKEK 255
+ + E + E K +S TI +L SE+ + ++ A +E +K
Sbjct: 233 VQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQK 292
Query: 256 LNQDLLSAVEAKEALEREVKIFQERLLAGQQVW---DASKQEVSLLKKS----------- 301
L + + + L E LL +Q + + E S+ KK+
Sbjct: 293 LKSSVNELTQKNQTL-------TENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLD 345
Query: 302 SSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREES 361
+L+ L AS+ ++ + S + + L+ LS + + + +++ + E
Sbjct: 346 CQQLQSRLSASETSLHRIHVE-LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREE 404
Query: 362 RDRMVSQLEAQISEL-------VEQLGKESG----FHQKALQRAQKAENMLETLQGQLTH 410
+++ QL+++I++L QLG+ G Q + ++ E + LQ +L+
Sbjct: 405 KEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSR 464
Query: 411 LEAEL----VSGGVLRDNLNFEKQKYLK---FLDQLSQKMK-----LDQMAAELGFD--- 455
LE +L + L+ L+ KQ++ + + K++ L+Q+ ++G
Sbjct: 465 LEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQK 524
Query: 456 -MRLDVVLARTEQ---LVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKI 511
L+ +L ++++ L+ E + L +E+ + + ++ L +K+
Sbjct: 525 IQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKL 584
Query: 512 A-QLEEEKQARTAL--VVERDNAHL-----TIRNLQKKVERLQKELNTCRDLHTELKAKL 563
Q E KQA+ L V+ AHL + +L+ V L +LN ++ ++L ++
Sbjct: 585 KNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQI 644
Query: 564 ADTNELKIKT-LEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERA 622
EL + +T DL D + + +++L + ++LD + ++ +E
Sbjct: 645 KAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHC 704
Query: 623 RNM---IEVVTSEMKTLKKSLEEAEKREKQL-ADFREV----------VSQMLGLNVTSL 668
+ ++ + +L++ EE E + K+L AD EV + Q LN T L
Sbjct: 705 SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLN-TDL 763
Query: 669 ALPDYEIIKCLE 680
L E+ K LE
Sbjct: 764 ELRATELSKQLE 775
Score = 63.2 bits (152), Expect = 8e-10
Identities = 59/257 (22%), Positives = 116/257 (45%), Gaps = 25/257 (9%)
Query: 33 EQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNA 92
+QL Q+ + E + + +S+L ++ +E +L E++S+K +
Sbjct: 1096 QQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESI 1155
Query: 93 RKSSLLTSLRDRVQELEEES-----------AALSTSKIRTEITAHAAIKENQELKKKVV 141
++ +T+L+D Q L ++ AA+ K +I KE +ELKK+ +
Sbjct: 1156 KE---ITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFI 1212
Query: 142 ELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLR 201
E KL KE E K+ +N K +T L + L ++ ++S ++ +L
Sbjct: 1213 EKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQR----RVSELE 1268
Query: 202 KENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLL 261
K+ + ++G+I +LE T+ ++ E +A E ++ E+ + Q K +L + L
Sbjct: 1269 KQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVL-------ELQRKLD 1321
Query: 262 SAVEAKEALEREVKIFQ 278
+ A + L RE + Q
Sbjct: 1322 NTTAAVQELGRENQSLQ 1338
Score = 59.7 bits (143), Expect = 9e-09
Identities = 108/529 (20%), Positives = 206/529 (38%), Gaps = 113/529 (21%)
Query: 25 LSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEM 84
++E+ +++L+ + +N++SE + E Q ++ +L E +C+ELK ++
Sbjct: 852 MTELSTVKDKLSKVSDSLKNSKSEF----------EKENQKGKAAILDLEKTCKELKHQL 901
Query: 85 ESYKENNARKSSLLTSLRDRVQE----LEEESAALSTSKIRTEITAHAAIKENQELKKKV 140
+ EN ++ L ++ +E L+ E ++ I+ + T KE Q+L+ +
Sbjct: 902 QVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNI 961
Query: 141 VELNEKLQKCSKENE----------------ENKKQ-------------------VSKNC 165
EL + ++ K+ E ENK Q + N
Sbjct: 962 NELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNY 1021
Query: 166 RKHEEFLTQL--------------RDCLDPDERNDKASDEDLILKLRDLRKENEFV---K 208
K +E QL R L E + EDLI + +N+ + K
Sbjct: 1022 EKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELK 1081
Query: 209 GQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAAS------------CTEEKE-- 254
LE+ E + + + + + E + ++K+ + C +EKE
Sbjct: 1082 TAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEIT 1141
Query: 255 KLNQDL----LSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLK 310
KLN++L L +++ L+ ++ ++ L Q D+ K V K++ L+ +K
Sbjct: 1142 KLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVK 1201
Query: 311 ASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLE 370
++ + F EK A L I EK M EE+ ++L
Sbjct: 1202 KEEEELKKE------FIEKEAKL-----------HSEIKEKEVGMKKHEENE----AKLT 1240
Query: 371 AQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQ 430
QI+ L E LG Q + +R + E + L+G++ LEA +++N + +
Sbjct: 1241 MQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEA------TVQNNQDERRA 1294
Query: 431 KYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIEN 479
+ L + KL EL +LD A ++L R + I++
Sbjct: 1295 LLERCLKGEGEIEKLQTKVLEL--QRKLDNTTAAVQELGRENQSLQIKH 1341
>gi|34577114 cytomatrix protein p110 [Homo sapiens]
Length = 957
Score = 103 bits (257), Expect = 6e-22
Identities = 142/656 (21%), Positives = 292/656 (44%), Gaps = 99/656 (15%)
Query: 19 EETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQ 78
E HL + +E+ N + + RS+L K + Q+ ++ +K+ S E + +
Sbjct: 336 ESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIR 395
Query: 79 ELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSK-IRTEITAHAAIKENQELK 137
+L+ E++ K N + + DR +E+++ S SK ++T+I + QEL
Sbjct: 396 DLEDEIQMLKANG------VLNTEDREEEIKQIEVYKSHSKFMKTKID-----QLKQELS 444
Query: 138 KKVVEL---NEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLI 194
KK EL KL+ S +N + C++H E L
Sbjct: 445 KKESELLALQTKLETLSNQNSD--------CKQHIEVL---------------------- 474
Query: 195 LKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKE 254
K + E+ + + E A R + S +N++ K+ TEEK
Sbjct: 475 -------------KESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKG 521
Query: 255 KLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQD 314
L ++ + E ER++ + Q+++ Q+ ++++ LK L+ +
Sbjct: 522 TLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDT 581
Query: 315 AVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDS-REESRD--RMVSQLEA 371
A+ T + + S +E+I L+ + E E++ E++S R+E++D V+ L+A
Sbjct: 582 ALATLE-EALSEKERIIERLKEQ------RERDDRERLEEIESFRKENKDLKEKVNALQA 634
Query: 372 QISE----LVEQLGKESGFHQKALQRAQKAENM---LETLQGQLTHLEAELVSGGVLRDN 424
+++E L++ S L+R K +++ +E + + + LEA+L + D+
Sbjct: 635 ELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDD 694
Query: 425 --LNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVL-ARTEQLVRLESNAVIENKT 481
+N E +K LD+ + + + A+ D L+++ E+ + + A +E+ T
Sbjct: 695 SRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLT 754
Query: 482 IAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQKK 541
+ H +K Q +++ + + + L ++K AQL EE + R + + ++ HL I L
Sbjct: 755 LRH-----MKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMAD-NSQHLQIEELMNA 808
Query: 542 VERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLN-KSRDQLEKMKEKAEKK 600
+E+ ++EL+ KA+LA T + E+ + +L + R QLE++ E ++
Sbjct: 809 LEKTRQELDA-------TKARLASTQQ---SLAEKEAHLANLRIERRKQLEEILEMKQEA 858
Query: 601 LMSVKSELDTT----EHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLAD 652
L++ SE D E A + K+ ++ + + + + + ++ + R K +AD
Sbjct: 859 LLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMAD 914
Score = 57.0 bits (136), Expect = 6e-08
Identities = 89/497 (17%), Positives = 214/497 (43%), Gaps = 73/497 (14%)
Query: 192 DLILKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTE 251
DL +L++L++EN+ ++ ++ I + + K ++ + +E+ S +
Sbjct: 149 DLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLK 208
Query: 252 EKEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKA 311
E+ +++ E + L+ ++ Q+ L + + +QE + +++
Sbjct: 209 EQMRVSH------EENQHLQLTIQALQDELRTQRDLNHLLQQESG----NRGAEHFTIEL 258
Query: 312 SQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEA 371
+++ Q+++ + K LLR + + EM+ R E++ + ++ +
Sbjct: 259 TEENFRRLQAEH-DRQAKELFLLR--------------KTLEEMELRIETQKQTLNARDE 303
Query: 372 QISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQK 431
I +L+E L + G K+L+ + + + Q++HLE L ++ N ++
Sbjct: 304 SIKKLLEML-QSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQ----KEKENIHLRE 358
Query: 432 YLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVR--------LESNAVIENKTIA 483
L QL Q A + +M+ D +A E+ +R L++N V+ +
Sbjct: 359 ELHRRSQL-QPEPAKTKALQTVIEMK-DTKIASLERNIRDLEDEIQMLKANGVLNTEDRE 416
Query: 484 HNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRN----LQ 539
+++ +E + H ++ KI QL++E + + ++ T+ N +
Sbjct: 417 EEIKQ--------IEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCK 468
Query: 540 KKVERLQKELNTCRD----LHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQL----- 590
+ +E L++ L L TE+ A E + ++TK ++DL + + L
Sbjct: 469 QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIR 528
Query: 591 --EKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTS----------EMKTLKK 638
+ M E E+K+ ++ +++ + + ++ ++ N+ + V S + TL++
Sbjct: 529 DMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEE 588
Query: 639 SLEEAEKREKQLADFRE 655
+L E E+ ++L + RE
Sbjct: 589 ALSEKERIIERLKEQRE 605
Score = 42.4 bits (98), Expect = 0.002
Identities = 44/185 (23%), Positives = 84/185 (45%), Gaps = 4/185 (2%)
Query: 478 ENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDN-AHLTIR 536
EN + L K + S + S +K L +E+ AR +++ E+ +H +
Sbjct: 160 ENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQ 219
Query: 537 NLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKA-IEDLNKSRDQLEKMKE 595
+LQ ++ LQ EL T RDL+ L+ + + T+E T+ L D+ K
Sbjct: 220 HLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHF-TIELTEENFRRLQAEHDRQAKELF 278
Query: 596 KAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFRE 655
K L ++ ++T + E + ++E++ S+ KSLE+ +R +++A+
Sbjct: 279 LLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSK-GLPSKSLEDDNERTRRMAEAES 337
Query: 656 VVSQM 660
VS +
Sbjct: 338 QVSHL 342
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 102 bits (254), Expect = 1e-21
Identities = 124/608 (20%), Positives = 270/608 (44%), Gaps = 59/608 (9%)
Query: 79 ELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAA--------- 129
E + EM + KE R L R +ELEE+ +L K ++ A
Sbjct: 846 ETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEE 905
Query: 130 -----IKENQELKKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDER 184
IK +L+ KV E+NE+L+ + EE +++ RK E+ ++L+ +D
Sbjct: 906 RCDQLIKNKIQLEAKVKEMNERLE----DEEEMNAELTAKKRKLEDECSELKKDID---- 957
Query: 185 NDKASDEDLILKLRDLRKENEFVKGQIV-ILEETINVHEM------EAKASRETIMRLAS 237
DL L L + KE + ++ + EE + E+ E KA +E +
Sbjct: 958 -------DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD 1010
Query: 238 EVNREQKKAASCTEEKEKLNQ---DLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQE 294
++ E+ K S ++ K KL Q DL ++E ++ + +++ + +L ++ +++
Sbjct: 1011 DLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKL---TQES 1067
Query: 295 VSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIRE 354
+ L+ +LE+ LK + + Q+ + +A L+ +L + + + E++
Sbjct: 1068 IMDLENDKLQLEEKLKKKEFDI-NQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEA 1126
Query: 355 MDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAE 414
+ +++ S L ++ E+ E+L + G ++ +K E + ++ L EA
Sbjct: 1127 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE--EAT 1184
Query: 415 L---VSGGVLRDNLNFEKQKYLKFLDQLSQ-KMKLDQMAAELGFDMRLDVVLARTEQLVR 470
L + LR + + +D L + K KL++ +E F + LD V + EQ+++
Sbjct: 1185 LQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE--FKLELDDVTSNMEQIIK 1242
Query: 471 LESNAVIENKTI---AHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVE 527
++N ++T+ A+ + KL+ + L + L+ + +L + + + AL+ +
Sbjct: 1243 AKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQ 1302
Query: 528 RDNAHLTIRNLQKKVER-LQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIED---- 582
L+ + ++R L++E L L++ D + L+ + E+T+A +
Sbjct: 1303 LTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV 1362
Query: 583 LNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEE 642
L+K+ ++ + + K E + EL+ + + + + A +E V ++ +L+K+
Sbjct: 1363 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHR 1422
Query: 643 AEKREKQL 650
+ + L
Sbjct: 1423 LQNEIEDL 1430
Score = 95.1 bits (235), Expect = 2e-19
Identities = 128/652 (19%), Positives = 269/652 (41%), Gaps = 90/652 (13%)
Query: 59 AQSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTS 118
A+ L + E +E+ +E +E NA ++ L D EL+++ L +
Sbjct: 903 AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELT 962
Query: 119 KIRTEITAHAAIKENQELKKKVVELNEKLQKCSKE-----------------NEENKKQV 161
+ E HA + + L +++ L+E + K +KE E+ +
Sbjct: 963 LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSL 1022
Query: 162 SKNCRKHEEFLTQLRDCLDPD-------ERNDKASDEDLILKLRDLRK-ENEFVKGQIVI 213
SK+ K E+ + L L+ + ER + + DL L + EN+ ++ + +
Sbjct: 1023 SKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKL 1082
Query: 214 LEETINVHEMEAKASRETI--MRLASEVNREQKKAASCTEEKEKLNQDLLSAVEAKEALE 271
++ ++++ +K E + ++L ++ Q + EE E + + L
Sbjct: 1083 KKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLS 1142
Query: 272 REVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIA 331
RE++ ERL ++ A+ ++ + KK +E +K + ++A ++ + R+K A
Sbjct: 1143 RELEEISERL---EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHA 1199
Query: 332 ALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKAL 391
+ + E+ + ++ R+ +LE + SE +L + ++ +
Sbjct: 1200 ------------------DSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII 1241
Query: 392 QRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAE 451
+ E + TL+ Q +L E Q+ L D +Q+ KL E
Sbjct: 1242 KAKANLEKVSRTLEDQANEYRVKLE-----------EAQRSLN--DFTTQRAKLQTENGE 1288
Query: 452 LGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQK---ERLESKELHMSLLR 508
L +L+ A QL R + + + + + L+ + K + L+S LLR
Sbjct: 1289 LA--RQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLR 1346
Query: 509 QKIAQLEEEKQARTAL--VVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADT 566
+ Q EEE +A+ L V+ + N+ + + + + +Q+ + +L +L D
Sbjct: 1347 E---QYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQR-TEELEEAKKKLAQRLQDA 1402
Query: 567 NE------LKIKTLEQTK-----AIEDL-------NKSRDQLEKMKEKAEKKLMSVKSEL 608
E K +LE+TK IEDL N + L+K + +K L K +
Sbjct: 1403 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKY 1462
Query: 609 DTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREVVSQM 660
+ ++ E + +++ AR++ + ++SLE E +++ + +E +S +
Sbjct: 1463 EESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDL 1514
Score = 95.1 bits (235), Expect = 2e-19
Identities = 149/663 (22%), Positives = 279/663 (42%), Gaps = 81/663 (12%)
Query: 25 LSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEM 84
L E + R Q ELA L + E S+L R K LS ++LK ++
Sbjct: 1265 LEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLT--RGK-LSYTQQMEDLKRQL 1321
Query: 85 ESY-KENNARKSSLLTS------LRDRVQELEEESAALST--SKIRTEITAHAAIKENQE 135
E K NA +L ++ LR++ +E E A L SK +E+ E
Sbjct: 1322 EEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDA 1381
Query: 136 LKK--KVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRD-----CLDPDERNDKA 188
+++ ++ E +KL + ++ EE + V+ C E+ +L++ +D + N A
Sbjct: 1382 IQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAA 1441
Query: 189 SDEDLILKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAAS 248
+ D +K+ F K IL E +E SE+ QK+A S
Sbjct: 1442 AALD--------KKQRNFDK----ILAEWKQKYEESQ-----------SELESSQKEARS 1478
Query: 249 CTEEKEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKS 308
+ E KL ++E E +RE K QE + + + V L+K +LE
Sbjct: 1479 LSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVE 1538
Query: 309 LKASQDAVTTSQSQYFSFREKIAALLRGRLSMT---GSTEDTILEKIREMDSREESRDRM 365
Q A+ +++ S + +LR +L E + EK EM+ + + R+
Sbjct: 1539 KLELQSALEEAEA---SLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRV 1595
Query: 366 VSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNL 425
V L+ L E+ + L+ +K E L ++ QL+H + +
Sbjct: 1596 VDSLQTS-------LDAETRSRNEVLRVKKKMEGDLNEMEIQLSHA-----------NRM 1637
Query: 426 NFEKQKYLKFLDQLSQ--KMKLDQMAAELGFDMRLDV-VLARTEQLVRLESNAVIENKTI 482
E QK +K L L + +++LD A D++ ++ ++ R L++ E E + +
Sbjct: 1638 AAEAQKQVKSLQSLLKDTQIQLDD-AVRANDDLKENIAIVERRNNLLQAELE---ELRAV 1693
Query: 483 AHNLQRKLK-TQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQKK 541
+R K ++E +E+ E L Q + + ++K+ + L + ++ +
Sbjct: 1694 VEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNA 1753
Query: 542 VERLQKELNTCRDLHTELKAKLADTN---ELKIKTLEQTKAIEDLNKSRDQLEKMKEKAE 598
E+ +K + + ELK K DT+ E K +EQT I+DL D+ E++ K
Sbjct: 1754 EEKAKKAITDAAMMAEELK-KEQDTSAHLERMKKNMEQT--IKDLQHRLDEAEQIALKGG 1810
Query: 599 KK-LMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREVV 657
KK L +++ + E E + ++R ++ + + +K+ + E+ +K L +++V
Sbjct: 1811 KKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLV 1870
Query: 658 SQM 660
++
Sbjct: 1871 DKL 1873
Score = 86.7 bits (213), Expect = 7e-17
Identities = 134/652 (20%), Positives = 264/652 (40%), Gaps = 64/652 (9%)
Query: 43 QNARSELAATLVKFECAQSELQ----DLRSKMLSKEVSCQELKAEMESYKENNARKSSLL 98
Q R +L ++ E + L+ D +++ + + Q +K ++E K + +
Sbjct: 1174 QKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDV 1233
Query: 99 TSLRDRV----QELEEESAALSTSKIRTEITAHAAIKENQELKKKVVELNEKLQKCSKEN 154
TS +++ LE+ S L + A + + + +L + + +++
Sbjct: 1234 TSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQL 1293
Query: 155 EENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRKENEFVKGQIVIL 214
EE + +S+ R + Q+ D E KA + L L+ R + + ++ Q
Sbjct: 1294 EEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNA-LAHALQSARHDCDLLREQY--- 1349
Query: 215 EETINVHEMEAKASRETIMRLA-SEVNREQKK----AASCTEE----KEKLNQDLLSAVE 265
EE E EAKA + ++ A SEV + + K A TEE K+KL Q L A E
Sbjct: 1350 EE-----ETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEE 1404
Query: 266 AKEA-------LEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTT 318
A EA LE+ Q + + S + L K +K L +
Sbjct: 1405 AVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEE 1464
Query: 319 SQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVE 378
SQS+ S +++ +L + + E+++ E+ R L+ +IS+L E
Sbjct: 1465 SQSELESSQKEARSLSTELFKLKNAYEESL--------EHLETFKRENKNLQEEISDLTE 1516
Query: 379 QLGKESGFHQKALQRAQKA--------ENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQ 430
QLG E G + L++ +K ++ LE + L H E +++ + + + E +
Sbjct: 1517 QLG-EGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE 1575
Query: 431 KYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKL 490
+ L D+ ++ K + LD +++R++ + + L
Sbjct: 1576 RKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHAN 1635
Query: 491 KTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQKKVERLQKELN 550
+ E + + SLL+ QL++ +A D+ I ++++ LQ EL
Sbjct: 1636 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRAN-------DDLKENIAIVERRNNLLQAELE 1688
Query: 551 TCRDL--HTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSEL 608
R + TE KLA+ + +E ++ ++ L+ L K+K E L ++SE+
Sbjct: 1689 ELRAVVEQTERSRKLAEQ-----ELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEV 1743
Query: 609 DTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREVVSQM 660
+ E + +E+A+ I + LKK + + E+ + + + +
Sbjct: 1744 EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL 1795
Score = 81.6 bits (200), Expect = 2e-15
Identities = 146/676 (21%), Positives = 280/676 (41%), Gaps = 95/676 (14%)
Query: 55 KFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAA 114
K E Q L+ K+ + +EL+ E+E+ + A+ L + L +ELEE S
Sbjct: 1095 KIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLS---RELEEISER 1151
Query: 115 LSTSKIRTEITAHAAIKENQELKKKVVELNE-KLQKCSKENEENKKQVSKNCRKHEEF-- 171
L + T + K E +K +L E LQ + KK E+
Sbjct: 1152 LEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDN 1211
Query: 172 LTQLRDCLDPDERNDKASDEDLILKLRDLRKENEFVKGQIVILEETINVHEM---EAKAS 228
L +++ L+ ++ K +D+ + + K ++ LE+ N + + EA+ S
Sbjct: 1212 LQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRS 1271
Query: 229 RETIMRLASEVNREQKKAASCTEEKEKLNQDL----LSAVEAKEALEREVKIFQERLLAG 284
+++ E + A EEKE L L LS + E L+R+++ + A
Sbjct: 1272 LNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNAL 1331
Query: 285 QQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGST 344
+++ + LL++ E ++ Q ++ + S+ +R K
Sbjct: 1332 AHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYET------------ 1379
Query: 345 EDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETL 404
+ I+ + EE++ ++ +L+ E VE + + +K R Q N +E L
Sbjct: 1380 -----DAIQRTEELEEAKKKLAQRLQ-DAEEAVEAVNAKCSSLEKTKHRLQ---NEIEDL 1430
Query: 405 QGQLTHLEAELVSGGVLRDNLNFE------KQKYLKFLDQLSQKMKLDQMAAELGFDMRL 458
+ A + + + NF+ KQKY + +L K + + F ++
Sbjct: 1431 MVDVERSNA--AAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLK- 1487
Query: 459 DVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEK 518
A E L LE+ ENK NLQ ++ E+L ++ L + QLE EK
Sbjct: 1488 ---NAYEESLEHLET-FKRENK----NLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEK 1539
Query: 519 -QARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQT 577
+ ++AL + A ++ + + K+ R Q E N + E++ KLA+ +E +EQ
Sbjct: 1540 LELQSAL----EEAEASLEHEEGKILRAQLEFN---QIKAEIERKLAEKDE----EMEQA 1588
Query: 578 K------------AIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNM 625
K +++ +SR+++ ++K+K E L ++ +L A E +++ +++
Sbjct: 1589 KRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSL 1648
Query: 626 ----------IEVVTSEMKTLKKSLEEAEKR----EKQLADFREVVSQMLGLNVTSLALP 671
++ LK+++ E+R + +L + R VV Q S L
Sbjct: 1649 QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQ----TERSRKLA 1704
Query: 672 DYEIIKCLER--LVHS 685
+ E+I+ ER L+HS
Sbjct: 1705 EQELIETSERVQLLHS 1720
Score = 81.3 bits (199), Expect = 3e-15
Identities = 121/502 (24%), Positives = 203/502 (40%), Gaps = 54/502 (10%)
Query: 194 ILKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEK 253
+LK + KE +K + ++ET+ E K E ++ L E N Q + + +
Sbjct: 841 LLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNL 900
Query: 254 EKLNQDLLSAVEAKEALEREVKIFQERLLAGQQV---WDASKQ----EVSLLKKSSSEL- 305
+ ++ K LE +VK ERL +++ A K+ E S LKK +L
Sbjct: 901 NDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLE 960
Query: 306 ------EKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSRE 359
EK A+++ V + E IA L + + ++ + + L+ ++ + +
Sbjct: 961 LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA-LDDLQVEEDKV 1019
Query: 360 ESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGG 419
S + +LE Q+ +L L +E + +K E L+ Q + LE
Sbjct: 1020 NSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLE------- 1072
Query: 420 VLRDNLNFEKQKYLKFLDQLSQKMKL-DQMAAELGFDMRLDVVLARTEQL---VRLESNA 475
D L E++ K D Q K+ D+ L +L AR E+L + E A
Sbjct: 1073 --NDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTA 1130
Query: 476 VIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAH-LT 534
+ + + +L R+L+ ERLE S+ + + E E Q + E H T
Sbjct: 1131 RAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEAT 1190
Query: 535 IRNLQKKVERLQKELNTCRDLHTELKAKL-ADTNELKIKTLEQTKAIEDLNKSRDQLEKM 593
L+KK EL D +K KL + +E K++ + T +E + K++ LEK+
Sbjct: 1191 AAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKV 1250
Query: 594 KEKAEKKLMSVKSEL--------DTTEHEAK---ENKERARNMIE-------------VV 629
E + + +L D T AK EN E AR + E
Sbjct: 1251 SRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSY 1310
Query: 630 TSEMKTLKKSLEEAEKREKQLA 651
T +M+ LK+ LEE K + LA
Sbjct: 1311 TQQMEDLKRQLEEEGKAKNALA 1332
Score = 56.6 bits (135), Expect = 8e-08
Identities = 92/422 (21%), Positives = 164/422 (38%), Gaps = 42/422 (9%)
Query: 23 DHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKA 82
+ L E +L R + + EL + L E A++ L+ K+L ++ ++KA
Sbjct: 1516 EQLGEGGKNVHELEKVRKQLEVEKLELQSAL---EEAEASLEHEEGKILRAQLEFNQIKA 1572
Query: 83 -----------EMESYKENNAR-KSSLLTSL----RDRVQ----------ELEEESAALS 116
EME K N+ R SL TSL R R + +L E LS
Sbjct: 1573 EIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLS 1632
Query: 117 TSKIRTEITAHAAIKENQELKKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLR 176
+ R A +K Q L K + + + + +EN V + + L +LR
Sbjct: 1633 HAN-RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR 1691
Query: 177 DCLDPDERNDKASDEDLI---LKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIM 233
++ ER+ K ++++LI +++ L +N + Q +E + + E + + +
Sbjct: 1692 AVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECR 1751
Query: 234 RLASEVNREQKKAASCTEEKEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQV-WDASK 292
+ + AA EE +K K+ +E+ +K Q RL +Q+ K
Sbjct: 1752 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGK 1811
Query: 293 QEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKI 352
+++ L+ ELE L+A Q S +I L T TE+ +
Sbjct: 1812 KQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKEL-------TYQTEEDKKNLL 1864
Query: 353 REMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLE 412
R D ++ + + V + Q E EQ +K +AE + + Q+ L
Sbjct: 1865 RLQDLVDKLQLK-VKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLR 1923
Query: 413 AE 414
A+
Sbjct: 1924 AK 1925
Score = 44.3 bits (103), Expect = 4e-04
Identities = 64/321 (19%), Positives = 132/321 (41%), Gaps = 38/321 (11%)
Query: 14 ASPAPEETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSK 73
A+ A ++ S + T+ QL+ + + +A + Q+EL++LR
Sbjct: 1638 AAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR------ 1691
Query: 74 EVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKEN 133
A +E + + L +RVQ L ++ +L K + E
Sbjct: 1692 --------AVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKME---------- 1733
Query: 134 QELKKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDL 193
+L + E+ E +Q+C E+ KK ++ EE L + +D ER K + E
Sbjct: 1734 SDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEE-LKKEQDTSAHLERM-KKNMEQT 1791
Query: 194 ILKLRDLRKENEFV-----KGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAAS 248
I L+ E E + K Q+ LE + E E +A ++ + + +++
Sbjct: 1792 IKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKE 1851
Query: 249 CTEEKEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKS 308
T + E+ ++LL + + L+ +VK ++ + ++ + + +S +K EL++
Sbjct: 1852 LTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQ---AEEAEEQANTNLSKFRKVQHELDE- 1907
Query: 309 LKASQDAVTTSQSQYFSFREK 329
+++ ++SQ R K
Sbjct: 1908 ---AEERADIAESQVNKLRAK 1925
Score = 38.1 bits (87), Expect = 0.029
Identities = 44/223 (19%), Positives = 91/223 (40%), Gaps = 27/223 (12%)
Query: 455 DMRLDVVLARTE-----QLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMSLLRQ 509
D RL ++ R + QL+R+E ++E + +Q ++ + K L
Sbjct: 780 DERLSRIITRMQAQARGQLMRIEFKKIVERRDALLVIQWNIRAF---MGVKNWPWMKLYF 836
Query: 510 KIAQLEEEKQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNEL 569
KI L + + + ++ L+K R ++L ++ + L + N+L
Sbjct: 837 KIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARR-------KELEEKMVSLLQEKNDL 889
Query: 570 KIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVV 629
+++ + + D + DQL K K + E K+ + L+ E E + R +
Sbjct: 890 QLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKL---- 945
Query: 630 TSEMKTLKKSLEEAE------KREKQLAD--FREVVSQMLGLN 664
E LKK +++ E ++EK + + + +M GL+
Sbjct: 946 EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 988
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 101 bits (252), Expect = 2e-21
Identities = 141/673 (20%), Positives = 281/673 (41%), Gaps = 69/673 (10%)
Query: 24 HLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAE 83
HL + +E+ N + R E A K + Q+ ++ SK+ S E ++L+ E
Sbjct: 345 HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEE 404
Query: 84 MESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVEL 143
++ K N A S +R +E+++ S SK +K KV +L
Sbjct: 405 IQMLKSNGA------LSTEEREEEMKQMEVYRSHSKF---------------MKNKVEQL 443
Query: 144 NEKLQKCSKENEENKK----------QVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDL 193
E+L + EE KK QV + + + L L+ L E L
Sbjct: 444 KEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKL-----------ETL 492
Query: 194 ILKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEK 253
+ D ++ E +K + E+ + + E A R + + +N++ K+ EEK
Sbjct: 493 TNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEK 552
Query: 254 EKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQ 313
++ + + ER+V + Q+++ Q+ ++++S LK+ L+ +
Sbjct: 553 GTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTD 612
Query: 314 DAVTTSQSQYFSFREKIAAL--LRGRLSMTGSTE-DTILEKIREMDSREESRDRMVSQLE 370
A+TT + I L R R E D + ++++ + +S+ E
Sbjct: 613 TALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKE 672
Query: 371 AQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSG--GVLRDNLNFE 428
A + +L E + K R + E LE + + +E++L L + E
Sbjct: 673 ASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPE 732
Query: 429 KQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQR 488
++ L++ + K + A+ D L++ L +E+ ++K IA L+R
Sbjct: 733 MSDRIQHLEREITRYKDESSKAQAEVDRLLEI-------LKEVENEKNDKDKKIA-ELER 784
Query: 489 KLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQKKVERLQKE 548
++K Q +++ + + + ++K AQ+ EE + R DN + + + LQ + L+K+
Sbjct: 785 QVKDQNKKVANLKHKEQVEKKKSAQMLEEARRR------EDNLNDSSQQLQ---DSLRKK 835
Query: 549 LNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSEL 608
+ +L L+ + T E ++ ++ A + K ++L EK +++L S+K++L
Sbjct: 836 DDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKL 895
Query: 609 DTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREVVSQMLGLNVTSL 668
+T+ E + N+ K L++ LE K+E LA E + + L ++S
Sbjct: 896 SSTQQSLAEKETHLTNL---RAERRKHLEEVLE--MKQEALLAAISEKDANIALLELSSS 950
Query: 669 ALPDYEIIKCLER 681
E + L+R
Sbjct: 951 KKKTQEEVAALKR 963
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 101 bits (251), Expect = 3e-21
Identities = 138/656 (21%), Positives = 283/656 (43%), Gaps = 89/656 (13%)
Query: 43 QNARSELAATLVKFECAQSELQDLRSKM---------LSKEVSCQELKAEMESYKENNAR 93
+ AR+E A K + AQ+EL+++ + LSKE+S E A++ +E
Sbjct: 1297 ERARAEAAE---KLQRAQAELENVSGALNEAESKTIRLSKELSSTE--AQLHDAQELLQE 1351
Query: 94 KSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKEN--QELKKKVVELNEKLQKCS 151
++ +L RV+ +E E+A L R ++ AA +E +EL+ +L+E ++
Sbjct: 1352 ETRAKLALGSRVRAMEAEAAGL-----REQLEEEAAARERAGRELQTAQAQLSEWRRRQE 1406
Query: 152 KE------NEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRKENE 205
+E EE +++ ++ + L + + +D ER + ++L DL ++ +
Sbjct: 1407 EEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQ 1466
Query: 206 FVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLLSAVE 265
V LE+ + + ++R E R + + L + L E
Sbjct: 1467 LVS----TLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQE 1522
Query: 266 AKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFS 325
A+E LER+ + + L + +SK +V KS ELE++ + ++ A ++Q
Sbjct: 1523 AREELERQNRALRAEL----EALLSSKDDVG---KSVHELERACRVAEQAANDLRAQVTE 1575
Query: 326 FREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESG 385
+++ A +L + + + + R++ R+E+ + QL Q+ + + +E
Sbjct: 1576 LEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERK 1635
Query: 386 FHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKL 445
A+ +K L+G+L L+A++ S G ++ + +K + +L ++++
Sbjct: 1636 QRTLAVAARKK-------LEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEE 1688
Query: 446 DQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMS 505
+ + E F + ++L LE+ + + +A + + + + Q++R E + +
Sbjct: 1689 TRTSREEIFSQNRE----SEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVAN 1744
Query: 506 LLRQKIAQLEEEKQAR-------TALVVERDNAHLT---IRNLQKKVERLQKELNTCRDL 555
K A LEE++Q L E+ N+ L R L +VE L EL+ R
Sbjct: 1745 GNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSF 1804
Query: 556 HT--------------ELKAKLADTNE------------LKIKTLEQTKAIEDLNKSRDQ 589
EL+ +L + + L+ K + + +E + R
Sbjct: 1805 SAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERIL 1864
Query: 590 LEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEK 645
K+ +AEK+L V +++ E + ++ R+ +E +K LK+ LEEAE+
Sbjct: 1865 SGKLVRRAEKRLKEVVLQVE----EERRVADQLRDQLEKGNLRVKQLKRQLEEAEE 1916
Score = 93.2 bits (230), Expect = 8e-19
Identities = 148/695 (21%), Positives = 286/695 (41%), Gaps = 86/695 (12%)
Query: 23 DHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKA 82
D L + R++L + SEL +V+ Q ++LR+++ KE +EL+A
Sbjct: 1066 DRLRKEEKGRQELEKLKRRLDGESSELQEQMVE---QQQRAEELRAQLGRKE---EELQA 1119
Query: 83 EMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVE 142
+ ++ ++ LL SLR+ L E L + ++ +EL+ E
Sbjct: 1120 ALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGE 1179
Query: 143 LNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRK 202
L + L + + E K+ E+ +T+L+ L+ + R +A+ +++LR+
Sbjct: 1180 LEDTLDSTNAQQELRSKR--------EQEVTELKKTLEEETRIHEAA-------VQELRQ 1224
Query: 203 ENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLLS 262
+ G+ L E + A +T + L +EV+ + + +S +++ Q
Sbjct: 1225 RHGQALGE---LAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQ---- 1277
Query: 263 AVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELE-----------KSLKA 311
+ LE +++ Q R G++ A + L+++ +ELE K+++
Sbjct: 1278 ---RRRRLELQLQEVQGRAGDGER---ARAEAAEKLQRAQAELENVSGALNEAESKTIRL 1331
Query: 312 SQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDT------ILEKIREMDSREESRDRM 365
S++ ++++++Q +E + R +L++ + E++ E + E R
Sbjct: 1332 SKE-LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRE 1390
Query: 366 VSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLE--AELVSGGVLR- 422
+ +AQ+SE + +E+G + + ++A E L +L + + G R
Sbjct: 1391 LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRL 1450
Query: 423 ----DNLNFEKQKYLKFLDQLSQKM-KLDQMAAELGFDMRLDVVLARTEQLVRLESNAVI 477
D+ + ++ + + L +K K DQ+ AE VL E+ R E+
Sbjct: 1451 QQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE-----EKAAVLRAVEERERAEAEGR- 1504
Query: 478 ENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNA----HL 533
E + A +L R L+ ++E E E LR ++ L K V E + A
Sbjct: 1505 EREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQ 1564
Query: 534 TIRNLQKKVERLQKELNTCRD-----------LHTELKAKLADTNELKIKTLEQ-TKAIE 581
+L+ +V L+ EL D L T+ + L +E + Q K +
Sbjct: 1565 AANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLR 1624
Query: 582 DLNKSRDQLEKMKE---KAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKK 638
D RD+ K + A KKL EL A + KE A + + ++MK L +
Sbjct: 1625 DAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWR 1684
Query: 639 SLEEAE-KREKQLADFREVVSQMLGLNVTSLALPD 672
+EE RE+ + RE ++ GL L L +
Sbjct: 1685 EVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQE 1719
Score = 86.3 bits (212), Expect = 9e-17
Identities = 139/671 (20%), Positives = 278/671 (41%), Gaps = 78/671 (11%)
Query: 42 AQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSL 101
A+ R LAA + E SEL+ +++ +E ++++ E + +++ + L +
Sbjct: 931 AEETRGRLAARKQELELVVSELE---ARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAE 987
Query: 102 RDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVELNEKLQKCSK---ENEENK 158
Q+L+ E + E +N +L K+ L ++L + S E EE
Sbjct: 988 EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKV 1047
Query: 159 KQVSKNCRKHEEFLTQLRDCLDPDERNDKASDE----------DLILKLRDLRKENEFVK 208
K ++K K+E + + D L +E+ + ++ +L ++ + ++ E ++
Sbjct: 1048 KSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELR 1107
Query: 209 GQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKE-------KLNQDLL 261
Q+ EE + A+ +L + Q A E+ E K +
Sbjct: 1108 AQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR 1167
Query: 262 SAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQS 321
E EAL E++ + A Q++ +QEV+ LKK+ E + +A+ +
Sbjct: 1168 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1227
Query: 322 QYFS-FREKIAALLRG-------RLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQI 373
Q E++ RG RL++ + E +R+E R +LE Q+
Sbjct: 1228 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRR-RRLELQL 1286
Query: 374 SELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYL 433
E+ + G +A ++ Q+A+ LE + G L E++ + + ++ + E Q +
Sbjct: 1287 QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIR--LSKELSSTEAQLHD 1344
Query: 434 KFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQL-VRLESNAVI------ENKTIAHNL 486
+Q++ ++ A+L R+ + A L +LE A E +T L
Sbjct: 1345 ------AQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQL 1398
Query: 487 QRKLKTQKERLESKEL----------HMSLLRQKIAQLEEE----KQARTALVVERDNAH 532
+ Q+E + E L Q++A+ E ++ R L E D+A
Sbjct: 1399 SEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDAT 1458
Query: 533 LTIRNLQKKVERLQKELNTCRDLHTELKAKL-----------ADTNELKIKTLEQTKAIE 581
+ + ++ V L+K+ L E KA + A+ E + + L T+A+E
Sbjct: 1459 MDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALE 1518
Query: 582 DLNKSRDQLEKMKE--KAE-KKLMSVKSELDTTEHE---AKENKERARNMIEVVTSEMKT 635
+ ++R++LE+ +AE + L+S K ++ + HE A E+A N + +E++
Sbjct: 1519 EEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELED 1578
Query: 636 LKKSLEEAEKR 646
+ E+A+ R
Sbjct: 1579 ELTAAEDAKLR 1589
Score = 81.6 bits (200), Expect = 2e-15
Identities = 147/664 (22%), Positives = 268/664 (40%), Gaps = 90/664 (13%)
Query: 24 HLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAE 83
H+ E+ E R Q + A + KFE L+D SK+ + ++ AE
Sbjct: 976 HIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAE 1035
Query: 84 MESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELK--KKVV 141
S Q EEE S +K+R + A A E++ K K
Sbjct: 1036 FSS-------------------QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQ 1076
Query: 142 ELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLR 201
EL + ++ E+ E ++Q+ + ++ EE QL R
Sbjct: 1077 ELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLG------------------------R 1112
Query: 202 KENEFVKGQIVILEETINVHEMEAKASRETIMRLA-SEVNREQKKAASCTEEKEKLNQDL 260
KE E ++ + E+ K+ RE LA ++ + E ++ A EK++ +DL
Sbjct: 1113 KEEE-LQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQR--RDL 1169
Query: 261 LSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQ 320
E EAL E++ + A Q++ +QEV+ LKK+ E + +A+ +
Sbjct: 1170 ---GEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRH 1226
Query: 321 SQYF-SFREKIAALLRG-------RLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQ 372
Q E++ RG RL++ + E +R+E R +LE Q
Sbjct: 1227 GQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRR-RRLELQ 1285
Query: 373 ISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKY 432
+ E+ + G +A ++ Q+A+ LE + G L E++ + + ++ + E Q +
Sbjct: 1286 LQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIR--LSKELSSTEAQLH 1343
Query: 433 LKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQL-VRLESNAVIENKT--IAHNLQRK 489
+Q++ ++ A+L R+ + A L +LE A + Q +
Sbjct: 1344 ------DAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQ 1397
Query: 490 LKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQKKVERLQKEL 549
L + R E + + + + E +A T + E+ T+ L++ RLQ+EL
Sbjct: 1398 LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTE---TVDRLERGRRRLQQEL 1454
Query: 550 NTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLN-----KSRDQLEKMKEKAEKKLMSV 604
+ + E + +L T E K + +Q A E + R++ E + E + +S+
Sbjct: 1455 DDA-TMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSL 1513
Query: 605 KSELDTTEHEAKENKER----ARNMIEVVTSEMKTLKKSLEEAEK----REKQLADFREV 656
L+ E EA+E ER R +E + S + KS+ E E+ E+ D R
Sbjct: 1514 TRALE-EEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQ 1572
Query: 657 VSQM 660
V+++
Sbjct: 1573 VTEL 1576
Score = 75.1 bits (183), Expect = 2e-13
Identities = 97/440 (22%), Positives = 202/440 (45%), Gaps = 49/440 (11%)
Query: 232 IMRLASEVNREQKKAASCTEEKEKLNQ---DLLSAVEAKEALEREVKIFQERLLAGQQVW 288
+ L + V E++ + EK++L Q +L + +EA+E +++++ + A + +
Sbjct: 949 VSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKF 1008
Query: 289 DASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTI 348
+ +++ LL+ +S+L K K +D + SQ EK+ +L + RL + D +
Sbjct: 1009 E---EDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIAD-M 1064
Query: 349 LEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQL 408
+++R+ + + +++ +L+ + SEL EQ+ ++ Q+A + + E LQ L
Sbjct: 1065 EDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQ---QQRAEELRAQLGRKEEELQAAL 1121
Query: 409 THLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQL 468
E E G R L ++ L + + ++ +++A R D+ E+L
Sbjct: 1122 ARAEDE----GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDL----GEEL 1173
Query: 469 VRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVER 528
L +E+ + N Q++L++++E+ E EL + LEEE + A V E
Sbjct: 1174 EALRGE--LEDTLDSTNAQQELRSKREQ-EVTELKKT--------LEEETRIHEAAVQEL 1222
Query: 529 DNAH-LTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSR 587
H + L +++E+ ++ L+A+++ E + L +R
Sbjct: 1223 RQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVS----------ELRAELSSLQTAR 1272
Query: 588 DQLEKMKEKAEKKLMSVKSELDTTEH---EAKENKERARNMIEVVT-----SEMKTLKKS 639
+ E+ + + E +L V+ E EA E +RA+ +E V+ +E KT++ S
Sbjct: 1273 QEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLS 1332
Query: 640 LEEAEKREKQLADFREVVSQ 659
+E E QL D +E++ +
Sbjct: 1333 -KELSSTEAQLHDAQELLQE 1351
Score = 52.4 bits (124), Expect = 1e-06
Identities = 70/346 (20%), Positives = 138/346 (39%), Gaps = 35/346 (10%)
Query: 349 LEKIREMDSREESR-DRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQ 407
++++++ +RE V+QLE + + L EQL E+ +A + + + L+
Sbjct: 889 VQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELV 948
Query: 408 LTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLS----------QKMKLDQMAAELGFDMR 457
++ LEA + + EK++ + + +L QK++L+++ E
Sbjct: 949 VSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKF 1008
Query: 458 LDVVLARTEQ--------------LVRLESNAVIENKTIAHNLQRKLKTQ------KERL 497
+ +L +Q L S A E + + + +LK + ++RL
Sbjct: 1009 EEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRL 1068
Query: 498 ESKELHMSLLRQKIAQLE-EEKQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLH 556
+E L + +L+ E + + +V ++ A L +K E LQ L D
Sbjct: 1069 RKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEG 1128
Query: 557 TELKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAK 616
L E + E + +E +R + EK + ++L +++ EL+ T
Sbjct: 1129 GARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTN 1188
Query: 617 ENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREVVSQMLG 662
+E + VT KTL+ EE E + + R+ Q LG
Sbjct: 1189 AQQELRSKREQEVTELKKTLE---EETRIHEAAVQELRQRHGQALG 1231
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 101 bits (251), Expect = 3e-21
Identities = 138/656 (21%), Positives = 283/656 (43%), Gaps = 89/656 (13%)
Query: 43 QNARSELAATLVKFECAQSELQDLRSKM---------LSKEVSCQELKAEMESYKENNAR 93
+ AR+E A K + AQ+EL+++ + LSKE+S E A++ +E
Sbjct: 1289 ERARAEAAE---KLQRAQAELENVSGALNEAESKTIRLSKELSSTE--AQLHDAQELLQE 1343
Query: 94 KSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKEN--QELKKKVVELNEKLQKCS 151
++ +L RV+ +E E+A L R ++ AA +E +EL+ +L+E ++
Sbjct: 1344 ETRAKLALGSRVRAMEAEAAGL-----REQLEEEAAARERAGRELQTAQAQLSEWRRRQE 1398
Query: 152 KE------NEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRKENE 205
+E EE +++ ++ + L + + +D ER + ++L DL ++ +
Sbjct: 1399 EEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQ 1458
Query: 206 FVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLLSAVE 265
V LE+ + + ++R E R + + L + L E
Sbjct: 1459 LVS----TLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQE 1514
Query: 266 AKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFS 325
A+E LER+ + + L + +SK +V KS ELE++ + ++ A ++Q
Sbjct: 1515 AREELERQNRALRAEL----EALLSSKDDVG---KSVHELERACRVAEQAANDLRAQVTE 1567
Query: 326 FREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESG 385
+++ A +L + + + + R++ R+E+ + QL Q+ + + +E
Sbjct: 1568 LEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERK 1627
Query: 386 FHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKL 445
A+ +K L+G+L L+A++ S G ++ + +K + +L ++++
Sbjct: 1628 QRTLAVAARKK-------LEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEE 1680
Query: 446 DQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMS 505
+ + E F + ++L LE+ + + +A + + + + Q++R E + +
Sbjct: 1681 TRTSREEIFSQNRE----SEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVAN 1736
Query: 506 LLRQKIAQLEEEKQAR-------TALVVERDNAHLT---IRNLQKKVERLQKELNTCRDL 555
K A LEE++Q L E+ N+ L R L +VE L EL+ R
Sbjct: 1737 GNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSF 1796
Query: 556 HT--------------ELKAKLADTNE------------LKIKTLEQTKAIEDLNKSRDQ 589
EL+ +L + + L+ K + + +E + R
Sbjct: 1797 SAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERIL 1856
Query: 590 LEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEK 645
K+ +AEK+L V +++ E + ++ R+ +E +K LK+ LEEAE+
Sbjct: 1857 SGKLVRRAEKRLKEVVLQVE----EERRVADQLRDQLEKGNLRVKQLKRQLEEAEE 1908
Score = 93.2 bits (230), Expect = 8e-19
Identities = 148/695 (21%), Positives = 286/695 (41%), Gaps = 86/695 (12%)
Query: 23 DHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKA 82
D L + R++L + SEL +V+ Q ++LR+++ KE +EL+A
Sbjct: 1058 DRLRKEEKGRQELEKLKRRLDGESSELQEQMVE---QQQRAEELRAQLGRKE---EELQA 1111
Query: 83 EMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVE 142
+ ++ ++ LL SLR+ L E L + ++ +EL+ E
Sbjct: 1112 ALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGE 1171
Query: 143 LNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRK 202
L + L + + E K+ E+ +T+L+ L+ + R +A+ +++LR+
Sbjct: 1172 LEDTLDSTNAQQELRSKR--------EQEVTELKKTLEEETRIHEAA-------VQELRQ 1216
Query: 203 ENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLLS 262
+ G+ L E + A +T + L +EV+ + + +S +++ Q
Sbjct: 1217 RHGQALGE---LAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQ---- 1269
Query: 263 AVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELE-----------KSLKA 311
+ LE +++ Q R G++ A + L+++ +ELE K+++
Sbjct: 1270 ---RRRRLELQLQEVQGRAGDGER---ARAEAAEKLQRAQAELENVSGALNEAESKTIRL 1323
Query: 312 SQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDT------ILEKIREMDSREESRDRM 365
S++ ++++++Q +E + R +L++ + E++ E + E R
Sbjct: 1324 SKE-LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRE 1382
Query: 366 VSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLE--AELVSGGVLR- 422
+ +AQ+SE + +E+G + + ++A E L +L + + G R
Sbjct: 1383 LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRL 1442
Query: 423 ----DNLNFEKQKYLKFLDQLSQKM-KLDQMAAELGFDMRLDVVLARTEQLVRLESNAVI 477
D+ + ++ + + L +K K DQ+ AE VL E+ R E+
Sbjct: 1443 QQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE-----EKAAVLRAVEERERAEAEGR- 1496
Query: 478 ENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNA----HL 533
E + A +L R L+ ++E E E LR ++ L K V E + A
Sbjct: 1497 EREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQ 1556
Query: 534 TIRNLQKKVERLQKELNTCRD-----------LHTELKAKLADTNELKIKTLEQ-TKAIE 581
+L+ +V L+ EL D L T+ + L +E + Q K +
Sbjct: 1557 AANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLR 1616
Query: 582 DLNKSRDQLEKMKE---KAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKK 638
D RD+ K + A KKL EL A + KE A + + ++MK L +
Sbjct: 1617 DAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWR 1676
Query: 639 SLEEAE-KREKQLADFREVVSQMLGLNVTSLALPD 672
+EE RE+ + RE ++ GL L L +
Sbjct: 1677 EVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQE 1711
Score = 86.3 bits (212), Expect = 9e-17
Identities = 139/671 (20%), Positives = 278/671 (41%), Gaps = 78/671 (11%)
Query: 42 AQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSL 101
A+ R LAA + E SEL+ +++ +E ++++ E + +++ + L +
Sbjct: 923 AEETRGRLAARKQELELVVSELE---ARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAE 979
Query: 102 RDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVELNEKLQKCSK---ENEENK 158
Q+L+ E + E +N +L K+ L ++L + S E EE
Sbjct: 980 EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKV 1039
Query: 159 KQVSKNCRKHEEFLTQLRDCLDPDERNDKASDE----------DLILKLRDLRKENEFVK 208
K ++K K+E + + D L +E+ + ++ +L ++ + ++ E ++
Sbjct: 1040 KSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELR 1099
Query: 209 GQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKE-------KLNQDLL 261
Q+ EE + A+ +L + Q A E+ E K +
Sbjct: 1100 AQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR 1159
Query: 262 SAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQS 321
E EAL E++ + A Q++ +QEV+ LKK+ E + +A+ +
Sbjct: 1160 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1219
Query: 322 QYFS-FREKIAALLRG-------RLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQI 373
Q E++ RG RL++ + E +R+E R +LE Q+
Sbjct: 1220 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRR-RRLELQL 1278
Query: 374 SELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYL 433
E+ + G +A ++ Q+A+ LE + G L E++ + + ++ + E Q +
Sbjct: 1279 QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIR--LSKELSSTEAQLHD 1336
Query: 434 KFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQL-VRLESNAVI------ENKTIAHNL 486
+Q++ ++ A+L R+ + A L +LE A E +T L
Sbjct: 1337 ------AQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQL 1390
Query: 487 QRKLKTQKERLESKEL----------HMSLLRQKIAQLEEE----KQARTALVVERDNAH 532
+ Q+E + E L Q++A+ E ++ R L E D+A
Sbjct: 1391 SEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDAT 1450
Query: 533 LTIRNLQKKVERLQKELNTCRDLHTELKAKL-----------ADTNELKIKTLEQTKAIE 581
+ + ++ V L+K+ L E KA + A+ E + + L T+A+E
Sbjct: 1451 MDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALE 1510
Query: 582 DLNKSRDQLEKMKE--KAE-KKLMSVKSELDTTEHE---AKENKERARNMIEVVTSEMKT 635
+ ++R++LE+ +AE + L+S K ++ + HE A E+A N + +E++
Sbjct: 1511 EEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELED 1570
Query: 636 LKKSLEEAEKR 646
+ E+A+ R
Sbjct: 1571 ELTAAEDAKLR 1581
Score = 81.6 bits (200), Expect = 2e-15
Identities = 147/664 (22%), Positives = 268/664 (40%), Gaps = 90/664 (13%)
Query: 24 HLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAE 83
H+ E+ E R Q + A + KFE L+D SK+ + ++ AE
Sbjct: 968 HIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAE 1027
Query: 84 MESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELK--KKVV 141
S Q EEE S +K+R + A A E++ K K
Sbjct: 1028 FSS-------------------QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQ 1068
Query: 142 ELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLR 201
EL + ++ E+ E ++Q+ + ++ EE QL R
Sbjct: 1069 ELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLG------------------------R 1104
Query: 202 KENEFVKGQIVILEETINVHEMEAKASRETIMRLA-SEVNREQKKAASCTEEKEKLNQDL 260
KE E ++ + E+ K+ RE LA ++ + E ++ A EK++ +DL
Sbjct: 1105 KEEE-LQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQR--RDL 1161
Query: 261 LSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQ 320
E EAL E++ + A Q++ +QEV+ LKK+ E + +A+ +
Sbjct: 1162 ---GEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRH 1218
Query: 321 SQYF-SFREKIAALLRG-------RLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQ 372
Q E++ RG RL++ + E +R+E R +LE Q
Sbjct: 1219 GQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRR-RRLELQ 1277
Query: 373 ISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKY 432
+ E+ + G +A ++ Q+A+ LE + G L E++ + + ++ + E Q +
Sbjct: 1278 LQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIR--LSKELSSTEAQLH 1335
Query: 433 LKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQL-VRLESNAVIENKT--IAHNLQRK 489
+Q++ ++ A+L R+ + A L +LE A + Q +
Sbjct: 1336 ------DAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQ 1389
Query: 490 LKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQKKVERLQKEL 549
L + R E + + + + E +A T + E+ T+ L++ RLQ+EL
Sbjct: 1390 LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTE---TVDRLERGRRRLQQEL 1446
Query: 550 NTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLN-----KSRDQLEKMKEKAEKKLMSV 604
+ + E + +L T E K + +Q A E + R++ E + E + +S+
Sbjct: 1447 DDA-TMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSL 1505
Query: 605 KSELDTTEHEAKENKER----ARNMIEVVTSEMKTLKKSLEEAEK----REKQLADFREV 656
L+ E EA+E ER R +E + S + KS+ E E+ E+ D R
Sbjct: 1506 TRALE-EEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQ 1564
Query: 657 VSQM 660
V+++
Sbjct: 1565 VTEL 1568
Score = 75.1 bits (183), Expect = 2e-13
Identities = 97/440 (22%), Positives = 202/440 (45%), Gaps = 49/440 (11%)
Query: 232 IMRLASEVNREQKKAASCTEEKEKLNQ---DLLSAVEAKEALEREVKIFQERLLAGQQVW 288
+ L + V E++ + EK++L Q +L + +EA+E +++++ + A + +
Sbjct: 941 VSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKF 1000
Query: 289 DASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTI 348
+ +++ LL+ +S+L K K +D + SQ EK+ +L + RL + D +
Sbjct: 1001 E---EDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIAD-M 1056
Query: 349 LEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQL 408
+++R+ + + +++ +L+ + SEL EQ+ ++ Q+A + + E LQ L
Sbjct: 1057 EDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQ---QQRAEELRAQLGRKEEELQAAL 1113
Query: 409 THLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQL 468
E E G R L ++ L + + ++ +++A R D+ E+L
Sbjct: 1114 ARAEDE----GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDL----GEEL 1165
Query: 469 VRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVER 528
L +E+ + N Q++L++++E+ E EL + LEEE + A V E
Sbjct: 1166 EALRGE--LEDTLDSTNAQQELRSKREQ-EVTELKKT--------LEEETRIHEAAVQEL 1214
Query: 529 DNAH-LTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSR 587
H + L +++E+ ++ L+A+++ E + L +R
Sbjct: 1215 RQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVS----------ELRAELSSLQTAR 1264
Query: 588 DQLEKMKEKAEKKLMSVKSELDTTEH---EAKENKERARNMIEVVT-----SEMKTLKKS 639
+ E+ + + E +L V+ E EA E +RA+ +E V+ +E KT++ S
Sbjct: 1265 QEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLS 1324
Query: 640 LEEAEKREKQLADFREVVSQ 659
+E E QL D +E++ +
Sbjct: 1325 -KELSSTEAQLHDAQELLQE 1343
Score = 52.4 bits (124), Expect = 1e-06
Identities = 70/346 (20%), Positives = 138/346 (39%), Gaps = 35/346 (10%)
Query: 349 LEKIREMDSREESR-DRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQ 407
++++++ +RE V+QLE + + L EQL E+ +A + + + L+
Sbjct: 881 VQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELV 940
Query: 408 LTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLS----------QKMKLDQMAAELGFDMR 457
++ LEA + + EK++ + + +L QK++L+++ E
Sbjct: 941 VSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKF 1000
Query: 458 LDVVLARTEQ--------------LVRLESNAVIENKTIAHNLQRKLKTQ------KERL 497
+ +L +Q L S A E + + + +LK + ++RL
Sbjct: 1001 EEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRL 1060
Query: 498 ESKELHMSLLRQKIAQLE-EEKQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLH 556
+E L + +L+ E + + +V ++ A L +K E LQ L D
Sbjct: 1061 RKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEG 1120
Query: 557 TELKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAK 616
L E + E + +E +R + EK + ++L +++ EL+ T
Sbjct: 1121 GARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTN 1180
Query: 617 ENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREVVSQMLG 662
+E + VT KTL+ EE E + + R+ Q LG
Sbjct: 1181 AQQELRSKREQEVTELKKTLE---EETRIHEAAVQELRQRHGQALG 1223
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 101 bits (251), Expect = 3e-21
Identities = 138/656 (21%), Positives = 283/656 (43%), Gaps = 89/656 (13%)
Query: 43 QNARSELAATLVKFECAQSELQDLRSKM---------LSKEVSCQELKAEMESYKENNAR 93
+ AR+E A K + AQ+EL+++ + LSKE+S E A++ +E
Sbjct: 1330 ERARAEAAE---KLQRAQAELENVSGALNEAESKTIRLSKELSSTE--AQLHDAQELLQE 1384
Query: 94 KSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKEN--QELKKKVVELNEKLQKCS 151
++ +L RV+ +E E+A L R ++ AA +E +EL+ +L+E ++
Sbjct: 1385 ETRAKLALGSRVRAMEAEAAGL-----REQLEEEAAARERAGRELQTAQAQLSEWRRRQE 1439
Query: 152 KE------NEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRKENE 205
+E EE +++ ++ + L + + +D ER + ++L DL ++ +
Sbjct: 1440 EEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQ 1499
Query: 206 FVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLLSAVE 265
V LE+ + + ++R E R + + L + L E
Sbjct: 1500 LVS----TLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQE 1555
Query: 266 AKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFS 325
A+E LER+ + + L + +SK +V KS ELE++ + ++ A ++Q
Sbjct: 1556 AREELERQNRALRAEL----EALLSSKDDVG---KSVHELERACRVAEQAANDLRAQVTE 1608
Query: 326 FREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESG 385
+++ A +L + + + + R++ R+E+ + QL Q+ + + +E
Sbjct: 1609 LEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERK 1668
Query: 386 FHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKL 445
A+ +K L+G+L L+A++ S G ++ + +K + +L ++++
Sbjct: 1669 QRTLAVAARKK-------LEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEE 1721
Query: 446 DQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMS 505
+ + E F + ++L LE+ + + +A + + + + Q++R E + +
Sbjct: 1722 TRTSREEIFSQNRE----SEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVAN 1777
Query: 506 LLRQKIAQLEEEKQAR-------TALVVERDNAHLT---IRNLQKKVERLQKELNTCRDL 555
K A LEE++Q L E+ N+ L R L +VE L EL+ R
Sbjct: 1778 GNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSF 1837
Query: 556 HT--------------ELKAKLADTNE------------LKIKTLEQTKAIEDLNKSRDQ 589
EL+ +L + + L+ K + + +E + R
Sbjct: 1838 SAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERIL 1897
Query: 590 LEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEK 645
K+ +AEK+L V +++ E + ++ R+ +E +K LK+ LEEAE+
Sbjct: 1898 SGKLVRRAEKRLKEVVLQVE----EERRVADQLRDQLEKGNLRVKQLKRQLEEAEE 1949
Score = 93.2 bits (230), Expect = 8e-19
Identities = 148/695 (21%), Positives = 286/695 (41%), Gaps = 86/695 (12%)
Query: 23 DHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKA 82
D L + R++L + SEL +V+ Q ++LR+++ KE +EL+A
Sbjct: 1099 DRLRKEEKGRQELEKLKRRLDGESSELQEQMVE---QQQRAEELRAQLGRKE---EELQA 1152
Query: 83 EMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVE 142
+ ++ ++ LL SLR+ L E L + ++ +EL+ E
Sbjct: 1153 ALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGE 1212
Query: 143 LNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRK 202
L + L + + E K+ E+ +T+L+ L+ + R +A+ +++LR+
Sbjct: 1213 LEDTLDSTNAQQELRSKR--------EQEVTELKKTLEEETRIHEAA-------VQELRQ 1257
Query: 203 ENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLLS 262
+ G+ L E + A +T + L +EV+ + + +S +++ Q
Sbjct: 1258 RHGQALGE---LAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQ---- 1310
Query: 263 AVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELE-----------KSLKA 311
+ LE +++ Q R G++ A + L+++ +ELE K+++
Sbjct: 1311 ---RRRRLELQLQEVQGRAGDGER---ARAEAAEKLQRAQAELENVSGALNEAESKTIRL 1364
Query: 312 SQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDT------ILEKIREMDSREESRDRM 365
S++ ++++++Q +E + R +L++ + E++ E + E R
Sbjct: 1365 SKE-LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRE 1423
Query: 366 VSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLE--AELVSGGVLR- 422
+ +AQ+SE + +E+G + + ++A E L +L + + G R
Sbjct: 1424 LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRL 1483
Query: 423 ----DNLNFEKQKYLKFLDQLSQKM-KLDQMAAELGFDMRLDVVLARTEQLVRLESNAVI 477
D+ + ++ + + L +K K DQ+ AE VL E+ R E+
Sbjct: 1484 QQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE-----EKAAVLRAVEERERAEAEGR- 1537
Query: 478 ENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNA----HL 533
E + A +L R L+ ++E E E LR ++ L K V E + A
Sbjct: 1538 EREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQ 1597
Query: 534 TIRNLQKKVERLQKELNTCRD-----------LHTELKAKLADTNELKIKTLEQ-TKAIE 581
+L+ +V L+ EL D L T+ + L +E + Q K +
Sbjct: 1598 AANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLR 1657
Query: 582 DLNKSRDQLEKMKE---KAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKK 638
D RD+ K + A KKL EL A + KE A + + ++MK L +
Sbjct: 1658 DAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWR 1717
Query: 639 SLEEAE-KREKQLADFREVVSQMLGLNVTSLALPD 672
+EE RE+ + RE ++ GL L L +
Sbjct: 1718 EVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQE 1752
Score = 86.3 bits (212), Expect = 9e-17
Identities = 139/671 (20%), Positives = 278/671 (41%), Gaps = 78/671 (11%)
Query: 42 AQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSL 101
A+ R LAA + E SEL+ +++ +E ++++ E + +++ + L +
Sbjct: 964 AEETRGRLAARKQELELVVSELE---ARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAE 1020
Query: 102 RDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVELNEKLQKCSK---ENEENK 158
Q+L+ E + E +N +L K+ L ++L + S E EE
Sbjct: 1021 EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKV 1080
Query: 159 KQVSKNCRKHEEFLTQLRDCLDPDERNDKASDE----------DLILKLRDLRKENEFVK 208
K ++K K+E + + D L +E+ + ++ +L ++ + ++ E ++
Sbjct: 1081 KSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELR 1140
Query: 209 GQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKE-------KLNQDLL 261
Q+ EE + A+ +L + Q A E+ E K +
Sbjct: 1141 AQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRR 1200
Query: 262 SAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQS 321
E EAL E++ + A Q++ +QEV+ LKK+ E + +A+ +
Sbjct: 1201 DLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1260
Query: 322 QYFS-FREKIAALLRG-------RLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQI 373
Q E++ RG RL++ + E +R+E R +LE Q+
Sbjct: 1261 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRR-RRLELQL 1319
Query: 374 SELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYL 433
E+ + G +A ++ Q+A+ LE + G L E++ + + ++ + E Q +
Sbjct: 1320 QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIR--LSKELSSTEAQLHD 1377
Query: 434 KFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQL-VRLESNAVI------ENKTIAHNL 486
+Q++ ++ A+L R+ + A L +LE A E +T L
Sbjct: 1378 ------AQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQL 1431
Query: 487 QRKLKTQKERLESKEL----------HMSLLRQKIAQLEEE----KQARTALVVERDNAH 532
+ Q+E + E L Q++A+ E ++ R L E D+A
Sbjct: 1432 SEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDAT 1491
Query: 533 LTIRNLQKKVERLQKELNTCRDLHTELKAKL-----------ADTNELKIKTLEQTKAIE 581
+ + ++ V L+K+ L E KA + A+ E + + L T+A+E
Sbjct: 1492 MDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALE 1551
Query: 582 DLNKSRDQLEKMKE--KAE-KKLMSVKSELDTTEHE---AKENKERARNMIEVVTSEMKT 635
+ ++R++LE+ +AE + L+S K ++ + HE A E+A N + +E++
Sbjct: 1552 EEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELED 1611
Query: 636 LKKSLEEAEKR 646
+ E+A+ R
Sbjct: 1612 ELTAAEDAKLR 1622
Score = 81.6 bits (200), Expect = 2e-15
Identities = 147/664 (22%), Positives = 268/664 (40%), Gaps = 90/664 (13%)
Query: 24 HLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAE 83
H+ E+ E R Q + A + KFE L+D SK+ + ++ AE
Sbjct: 1009 HIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAE 1068
Query: 84 MESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELK--KKVV 141
S Q EEE S +K+R + A A E++ K K
Sbjct: 1069 FSS-------------------QAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQ 1109
Query: 142 ELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLR 201
EL + ++ E+ E ++Q+ + ++ EE QL R
Sbjct: 1110 ELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLG------------------------R 1145
Query: 202 KENEFVKGQIVILEETINVHEMEAKASRETIMRLA-SEVNREQKKAASCTEEKEKLNQDL 260
KE E ++ + E+ K+ RE LA ++ + E ++ A EK++ +DL
Sbjct: 1146 KEEE-LQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQR--RDL 1202
Query: 261 LSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQ 320
E EAL E++ + A Q++ +QEV+ LKK+ E + +A+ +
Sbjct: 1203 ---GEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRH 1259
Query: 321 SQYF-SFREKIAALLRG-------RLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQ 372
Q E++ RG RL++ + E +R+E R +LE Q
Sbjct: 1260 GQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRR-RRLELQ 1318
Query: 373 ISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKY 432
+ E+ + G +A ++ Q+A+ LE + G L E++ + + ++ + E Q +
Sbjct: 1319 LQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIR--LSKELSSTEAQLH 1376
Query: 433 LKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQL-VRLESNAVIENKT--IAHNLQRK 489
+Q++ ++ A+L R+ + A L +LE A + Q +
Sbjct: 1377 ------DAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQ 1430
Query: 490 LKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQKKVERLQKEL 549
L + R E + + + + E +A T + E+ T+ L++ RLQ+EL
Sbjct: 1431 LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTE---TVDRLERGRRRLQQEL 1487
Query: 550 NTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLN-----KSRDQLEKMKEKAEKKLMSV 604
+ + E + +L T E K + +Q A E + R++ E + E + +S+
Sbjct: 1488 DDA-TMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSL 1546
Query: 605 KSELDTTEHEAKENKER----ARNMIEVVTSEMKTLKKSLEEAEK----REKQLADFREV 656
L+ E EA+E ER R +E + S + KS+ E E+ E+ D R
Sbjct: 1547 TRALE-EEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQ 1605
Query: 657 VSQM 660
V+++
Sbjct: 1606 VTEL 1609
Score = 75.1 bits (183), Expect = 2e-13
Identities = 97/440 (22%), Positives = 202/440 (45%), Gaps = 49/440 (11%)
Query: 232 IMRLASEVNREQKKAASCTEEKEKLNQ---DLLSAVEAKEALEREVKIFQERLLAGQQVW 288
+ L + V E++ + EK++L Q +L + +EA+E +++++ + A + +
Sbjct: 982 VSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKF 1041
Query: 289 DASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTI 348
+ +++ LL+ +S+L K K +D + SQ EK+ +L + RL + D +
Sbjct: 1042 E---EDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIAD-M 1097
Query: 349 LEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQL 408
+++R+ + + +++ +L+ + SEL EQ+ ++ Q+A + + E LQ L
Sbjct: 1098 EDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQ---QQRAEELRAQLGRKEEELQAAL 1154
Query: 409 THLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQL 468
E E G R L ++ L + + ++ +++A R D+ E+L
Sbjct: 1155 ARAEDE----GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDL----GEEL 1206
Query: 469 VRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVER 528
L +E+ + N Q++L++++E+ E EL + LEEE + A V E
Sbjct: 1207 EALRGE--LEDTLDSTNAQQELRSKREQ-EVTELKKT--------LEEETRIHEAAVQEL 1255
Query: 529 DNAH-LTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSR 587
H + L +++E+ ++ L+A+++ E + L +R
Sbjct: 1256 RQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVS----------ELRAELSSLQTAR 1305
Query: 588 DQLEKMKEKAEKKLMSVKSELDTTEH---EAKENKERARNMIEVVT-----SEMKTLKKS 639
+ E+ + + E +L V+ E EA E +RA+ +E V+ +E KT++ S
Sbjct: 1306 QEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLS 1365
Query: 640 LEEAEKREKQLADFREVVSQ 659
+E E QL D +E++ +
Sbjct: 1366 -KELSSTEAQLHDAQELLQE 1384
Score = 52.4 bits (124), Expect = 1e-06
Identities = 70/346 (20%), Positives = 138/346 (39%), Gaps = 35/346 (10%)
Query: 349 LEKIREMDSREESR-DRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQ 407
++++++ +RE V+QLE + + L EQL E+ +A + + + L+
Sbjct: 922 VQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELV 981
Query: 408 LTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLS----------QKMKLDQMAAELGFDMR 457
++ LEA + + EK++ + + +L QK++L+++ E
Sbjct: 982 VSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKF 1041
Query: 458 LDVVLARTEQ--------------LVRLESNAVIENKTIAHNLQRKLKTQ------KERL 497
+ +L +Q L S A E + + + +LK + ++RL
Sbjct: 1042 EEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRL 1101
Query: 498 ESKELHMSLLRQKIAQLE-EEKQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLH 556
+E L + +L+ E + + +V ++ A L +K E LQ L D
Sbjct: 1102 RKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEG 1161
Query: 557 TELKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAK 616
L E + E + +E +R + EK + ++L +++ EL+ T
Sbjct: 1162 GARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTN 1221
Query: 617 ENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREVVSQMLG 662
+E + VT KTL+ EE E + + R+ Q LG
Sbjct: 1222 AQQELRSKREQEVTELKKTLE---EETRIHEAAVQELRQRHGQALG 1264
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 100 bits (250), Expect = 4e-21
Identities = 133/651 (20%), Positives = 280/651 (43%), Gaps = 75/651 (11%)
Query: 30 VTREQLNHY--RNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESY 87
+T E NHY V+++ + A + + +L D+ K K++ ++L E +S
Sbjct: 723 LTIEMKNHYVPLKVSEDMKKSHDAII---DDLNRKLLDVTQKYTEKKLEMEKLLLENDSL 779
Query: 88 KENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVELNEKL 147
++ +R ++ ++ E+E AL ++ + + K+ ELKKK E EK+
Sbjct: 780 SKDVSRLETVFVP----PEKHEKEIIALKSNIVELK-------KQLSELKKKCGEDQEKI 828
Query: 148 QKCSKENEENKKQVSKN---CRKHEEFLTQLRDCLDPDER---NDKASDEDLILKLRDLR 201
+ EN KK +S + HEE L D L R + K ED+ + ++
Sbjct: 829 HALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIK 888
Query: 202 KENEFVKGQIV-----ILEETINVHEMEAK-ASRETIMRLASEVNRE-QKKAASCTEEKE 254
+NE +K + I E I++ E EAK +S MR + N E EE
Sbjct: 889 DKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIV 948
Query: 255 KLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQD 314
L+ ++ + + + ++ +K+ +++ ++ K LK SE + S++
Sbjct: 949 TLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEE 1008
Query: 315 AVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQIS 374
V ++ + +++I L + T ++EK EM E + R +L Q+
Sbjct: 1009 EVKKNKQENDKLKKEIFTLQKDLRDKT-----VLIEKSHEM---ERALSRKTDELNKQLK 1060
Query: 375 ELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLK 434
+L ++ + +K ++ K + + +Q L L L+ +LN
Sbjct: 1061 DLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGT------ 1114
Query: 435 FLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQK 494
++ L +++K Q E + + + QL+ + N+ + +A +LQ K +K
Sbjct: 1115 -IENLKEELKSMQRCYE-----KEQQTVTKLHQLLENQKNSSVP---LAEHLQIKEAFEK 1165
Query: 495 ERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQKKVE-RLQKELNTCR 553
E + +++ + + EEE Q + V + + + KK+E R +L+ +
Sbjct: 1166 E--------VGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYK 1217
Query: 554 DLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELD---- 609
++L+ +++ NE + +LN+ +++ + A+KK +S K E +
Sbjct: 1218 ATKSDLETQISSLNE----------KLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHF 1267
Query: 610 TTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREVVSQM 660
+ E E K+ KER + +T + +++S ++ E ++ ++ + V ++
Sbjct: 1268 SIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERL 1318
Score = 88.6 bits (218), Expect = 2e-17
Identities = 154/740 (20%), Positives = 302/740 (40%), Gaps = 127/740 (17%)
Query: 30 VTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKE 89
+T E + + + + +L VK+E A +E+ LR+++ E+ +E K + E
Sbjct: 514 LTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIE 573
Query: 90 NNARKSSLLTSLR-------DRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVE 142
N R L+ +V E+E ++ LS +K+ I A L +V E
Sbjct: 574 ENKRLQKELSMCEMEREKKGRKVTEMEGQAKELS-AKLALSIPAEKFENMKSSLSNEVNE 632
Query: 143 LNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDE------RNDKASDE----- 191
+KL + +E+E++ ++ + R+ E +L + P+E R ++ S E
Sbjct: 633 KAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKI 692
Query: 192 -DLILKLRDLRKE-------NEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQ 243
+L LK + L+KE N+ +K Q L + H + K S + + ++
Sbjct: 693 TELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLN 752
Query: 244 KKAASCTE-------EKEKL---NQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQ 293
+K T+ E EKL N L V E + + ++ ++A + K+
Sbjct: 753 RKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKK 812
Query: 294 EVSLLKKSSSE--------------LEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLS 339
++S LKK E L+K + V T + + + +A R L
Sbjct: 813 QLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLD 872
Query: 340 MTGSTEDTILEKIREMDSREESRDRM-------------VSQLEAQISELVEQLGKESGF 386
+ ED E ++ D E + + +++ EA++S L + + K
Sbjct: 873 VKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDS 932
Query: 387 HQKALQRAQKAENMLETLQGQLTHLEAEL-------------------------VSGGVL 421
+ + L +K + + TL ++ + EL + L
Sbjct: 933 NAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKEL 992
Query: 422 RDNLNFEKQKYLKFLDQLSQ-KMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENK 480
+D L+ + QKY +++ + K + D++ E+ F ++ D L V+ K
Sbjct: 993 KDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI-FTLQKD-----------LRDKTVLIEK 1040
Query: 481 TIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQK 540
+ H ++R L + + L + + L QK +++ K+ ++ + L ++NL +
Sbjct: 1041 S--HEMERALSRKTDELNKQ---LKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQ 1095
Query: 541 K-------VERLQKELN-TCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEK 592
K VE L+K LN T +L ELK+ + + + + +E+ S L +
Sbjct: 1096 KQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAE 1155
Query: 593 ---MKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKRE-- 647
+KE EK++ +K+ L E E++ E + + SE++ K++L++ E RE
Sbjct: 1156 HLQIKEAFEKEVGIIKASLREKEEESQNKMEE----VSKLQSEVQNTKQALKKLETREVV 1211
Query: 648 ---KQLADFREVVSQMLGLN 664
K A ++ +Q+ LN
Sbjct: 1212 DLSKYKATKSDLETQISSLN 1231
Score = 69.7 bits (169), Expect = 9e-12
Identities = 115/591 (19%), Positives = 242/591 (40%), Gaps = 77/591 (13%)
Query: 86 SYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVELNE 145
SY EN K L ++R + +++ L A E + +K+ E +
Sbjct: 422 SYSENEILKKEL-EAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIK 480
Query: 146 KLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERN-DKASDEDLILKLRDLRKEN 204
+L+ K+ ++ + ++ + L++ L + + + E+L +L+DL+ +
Sbjct: 481 QLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKY 540
Query: 205 EFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLLSAV 264
E ++ L I +EM + + +L E R QK+ + C E+EK + +
Sbjct: 541 EGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEME 600
Query: 265 -EAKE-ALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQ 322
+AKE + + + I E+ + + + EV+ K E+E+ + S + + +
Sbjct: 601 GQAKELSAKLALSIPAEKF---ENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRE 657
Query: 323 YFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGK 382
+ + K+A + E +++ S+LE + EL +++ +
Sbjct: 658 LENVKAKLA-----------------------QHVKPEEHEQVKSRLEQKSGELGKKITE 694
Query: 383 ESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQK 442
+ +Q + +K + L+ Q +L E+ + V K+ + +D L++K
Sbjct: 695 LTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRK 754
Query: 443 MKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKEL 502
+ LDV TE+ + +E ++EN +++ ++ R L+T E E
Sbjct: 755 L--------------LDVTQKYTEKKLEME-KLLLENDSLSKDVSR-LETVFVPPEKHEK 798
Query: 503 HMSLLRQKIAQLEEE-KQARTALVVERDNAHLTI---RNLQKKVERLQKELNTCRDLHTE 558
+ L+ I +L+++ + + +++ H NL+K + + T ++
Sbjct: 799 EIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMT 858
Query: 559 LKAKLADTNELKIKTLEQTKAIEDLN----KSRDQLEKMKEKAEKKLMSVKSE-LDTTEH 613
L LA TN + L+ K ED+N K +D+ E +K E +K+E + EH
Sbjct: 859 LNDTLAKTNR---ELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEH 915
Query: 614 EAK-------------------ENKERARNMIEVVTSEMKTLKKSLEEAEK 645
EAK N + + I + +E+K KK L+ ++
Sbjct: 916 EAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQE 966
Score = 67.4 bits (163), Expect = 4e-11
Identities = 107/470 (22%), Positives = 190/470 (40%), Gaps = 91/470 (19%)
Query: 28 VPV-TREQLNHYRN-VAQNARSELAATLVKFECAQSELQDLRSK----MLSKEVSCQELK 81
VPV T E++ N EL KFE E ++ K + E + ++K
Sbjct: 847 VPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIK 906
Query: 82 AEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIK---------- 131
AE S E+ A+ SSL S+R +VQ+ E A +T HA IK
Sbjct: 907 AEYISLAEHEAKMSSLSQSMR-KVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQ 965
Query: 132 -------------ENQELKKKVVE------LNEKLQKCSKENEENKKQVSKNCRKHEEFL 172
E E K K E L+E+ QK S EE KK +N + +E
Sbjct: 966 ECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIF 1025
Query: 173 TQLRDCLDPDERNDKASD---------EDLILKLRDL-------------------RKEN 204
T +D D +K+ + ++L +L+DL ++ +
Sbjct: 1026 TLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTS 1085
Query: 205 EFVKGQIVILEETINVHEMEA--KASRETIMRLASEVNREQK----------KAASCTEE 252
E + Q ++ ++ + + ++EA K+ TI L E+ Q+ K E
Sbjct: 1086 EILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLEN 1145
Query: 253 KEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLK-- 310
++ + L ++ KEA E+EV I + L ++ +EVS L+ +++LK
Sbjct: 1146 QKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKL 1205
Query: 311 ASQDAVTTS---------QSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREES 361
+++ V S ++Q S EK+A L R E+ + K +E+ +++E
Sbjct: 1206 ETREVVDLSKYKATKSDLETQISSLNEKLANLNR---KYEEVCEEVLHAKKKEISAKDE- 1261
Query: 362 RDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHL 411
++ + +E +I + E+ K + +R Q++ +E ++T L
Sbjct: 1262 KELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITEL 1311
Score = 67.0 bits (162), Expect = 6e-11
Identities = 141/600 (23%), Positives = 242/600 (40%), Gaps = 109/600 (18%)
Query: 102 RDRVQELEEESAALST-SKIRTEITAHAAIKENQELKKKVVELNEKLQKCSKENEENKKQ 160
RD V+ L + A +S + + + +A I +N +++ L+ S+ + ++
Sbjct: 200 RDAVEVLIKNGADISLLDALGHDSSYYARIGDN-------LDILTLLKTASENTNKGREL 252
Query: 161 VSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRKENEFVKGQIVILEETINV 220
K + LT ++D E N K+ + ++DL ENE +K E +
Sbjct: 253 WKKGPSLQQRNLTHMQD-----EVNVKSHQREH-QNIQDLEIENEDLK-------ERLRK 299
Query: 221 HEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLLSAVEAK--------EALER 272
+ E + + + L ++N E A E+EKL + LL+A E + EAL+
Sbjct: 300 IQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKL-KSLLAAKEKQHEESLRTIEALKN 358
Query: 273 EVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAA 332
K F+ L G ++++E LLK+ + S S QS R +
Sbjct: 359 RFKYFESDHL-GSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQS-----RSMLRP 412
Query: 333 LLRGRLSMTGSTEDTILEKIRE-----MDSREESRDRMVSQLEAQISELVEQLGKESGFH 387
L S T +E+ IL+K E +S ++ R ++ ++L +++E
Sbjct: 413 LELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAEC----------- 461
Query: 388 QKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQ 447
KAL A + E + E Q+ LE L + +K+ Y + K+ Q
Sbjct: 462 -KAL--ALECERVKEDSDEQIKQLEDAL---------KDVQKRMY-------ESEGKVKQ 502
Query: 448 MAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMSLL 507
M LA E L S A N + L+ +LK K + E + L
Sbjct: 503 MQTHF---------LALKEHLT---SEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKL 550
Query: 508 RQKIAQLEEEKQARTALVVE---RDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLA 564
R +I Q E ++VE RD L N +RLQKEL+ C ++ E K +
Sbjct: 551 RNQIKQNE--------MIVEEFKRDEGKLIEEN-----KRLQKELSMC-EMEREKKGRKV 596
Query: 565 DTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARN 624
E + K L A L+ ++ E MK ++ +L E E E++ +
Sbjct: 597 TEMEGQAKELSAKLA---LSIPAEKFENMKSSLSNEVNEKAKKLVEMERE----HEKSLS 649
Query: 625 MIEVVTSEMKTLKKSLEEAEKRE--KQLADFREVVSQMLGLNVTSLALPDYEIIKCLERL 682
I + E++ +K L + K E +Q+ E S LG +T L L + + K +E++
Sbjct: 650 EIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKV 709
Score = 36.2 bits (82), Expect = 0.11
Identities = 45/236 (19%), Positives = 96/236 (40%), Gaps = 42/236 (17%)
Query: 80 LKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKK 139
+KA + +E + K ++ L+ VQ ++ L T ++ +++ + A K +L+ +
Sbjct: 1170 IKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREV-VDLSKYKATKS--DLETQ 1226
Query: 140 VVELNEKLQKCSKENEE--------NKKQVS--------------------KNCRKHEEF 171
+ LNEKL +++ EE KK++S + C K
Sbjct: 1227 ISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTT 1286
Query: 172 LTQLRDCLDPDERNDKASDEDLILKLRDLRKENEFVKGQIVILEETINVHEMEAKASRET 231
+T+L+ + + +A D + L D+ + + + G L + K +
Sbjct: 1287 ITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNG----LSQLTYTSGNPTKRQSQL 1342
Query: 232 IMRLASEVNREQKKAASCTEEKEKL----NQDLLSAVEA---KEALEREVKIFQER 280
I L +V +++ A + +++ LLSA + ++ E ++I Q R
Sbjct: 1343 IDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQMR 1398
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 100 bits (250), Expect = 4e-21
Identities = 133/651 (20%), Positives = 280/651 (43%), Gaps = 75/651 (11%)
Query: 30 VTREQLNHY--RNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESY 87
+T E NHY V+++ + A + + +L D+ K K++ ++L E +S
Sbjct: 736 LTIEMKNHYVPLKVSEDMKKSHDAII---DDLNRKLLDVTQKYTEKKLEMEKLLLENDSL 792
Query: 88 KENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVELNEKL 147
++ +R ++ ++ E+E AL ++ + + K+ ELKKK E EK+
Sbjct: 793 SKDVSRLETVFVP----PEKHEKEIIALKSNIVELK-------KQLSELKKKCGEDQEKI 841
Query: 148 QKCSKENEENKKQVSKN---CRKHEEFLTQLRDCLDPDER---NDKASDEDLILKLRDLR 201
+ EN KK +S + HEE L D L R + K ED+ + ++
Sbjct: 842 HALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIK 901
Query: 202 KENEFVKGQIV-----ILEETINVHEMEAK-ASRETIMRLASEVNRE-QKKAASCTEEKE 254
+NE +K + I E I++ E EAK +S MR + N E EE
Sbjct: 902 DKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIV 961
Query: 255 KLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQD 314
L+ ++ + + + ++ +K+ +++ ++ K LK SE + S++
Sbjct: 962 TLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEE 1021
Query: 315 AVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQIS 374
V ++ + +++I L + T ++EK EM E + R +L Q+
Sbjct: 1022 EVKKNKQENDKLKKEIFTLQKDLRDKT-----VLIEKSHEM---ERALSRKTDELNKQLK 1073
Query: 375 ELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLK 434
+L ++ + +K ++ K + + +Q L L L+ +LN
Sbjct: 1074 DLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGT------ 1127
Query: 435 FLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQK 494
++ L +++K Q E + + + QL+ + N+ + +A +LQ K +K
Sbjct: 1128 -IENLKEELKSMQRCYE-----KEQQTVTKLHQLLENQKNSSVP---LAEHLQIKEAFEK 1178
Query: 495 ERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQKKVE-RLQKELNTCR 553
E + +++ + + EEE Q + V + + + KK+E R +L+ +
Sbjct: 1179 E--------VGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYK 1230
Query: 554 DLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELD---- 609
++L+ +++ NE + +LN+ +++ + A+KK +S K E +
Sbjct: 1231 ATKSDLETQISSLNE----------KLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHF 1280
Query: 610 TTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREVVSQM 660
+ E E K+ KER + +T + +++S ++ E ++ ++ + V ++
Sbjct: 1281 SIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERL 1331
Score = 88.6 bits (218), Expect = 2e-17
Identities = 154/740 (20%), Positives = 302/740 (40%), Gaps = 127/740 (17%)
Query: 30 VTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKE 89
+T E + + + + +L VK+E A +E+ LR+++ E+ +E K + E
Sbjct: 527 LTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIE 586
Query: 90 NNARKSSLLTSLR-------DRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVE 142
N R L+ +V E+E ++ LS +K+ I A L +V E
Sbjct: 587 ENKRLQKELSMCEMEREKKGRKVTEMEGQAKELS-AKLALSIPAEKFENMKSSLSNEVNE 645
Query: 143 LNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDE------RNDKASDE----- 191
+KL + +E+E++ ++ + R+ E +L + P+E R ++ S E
Sbjct: 646 KAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKI 705
Query: 192 -DLILKLRDLRKE-------NEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQ 243
+L LK + L+KE N+ +K Q L + H + K S + + ++
Sbjct: 706 TELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLN 765
Query: 244 KKAASCTE-------EKEKL---NQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQ 293
+K T+ E EKL N L V E + + ++ ++A + K+
Sbjct: 766 RKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKK 825
Query: 294 EVSLLKKSSSE--------------LEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLS 339
++S LKK E L+K + V T + + + +A R L
Sbjct: 826 QLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLD 885
Query: 340 MTGSTEDTILEKIREMDSREESRDRM-------------VSQLEAQISELVEQLGKESGF 386
+ ED E ++ D E + + +++ EA++S L + + K
Sbjct: 886 VKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDS 945
Query: 387 HQKALQRAQKAENMLETLQGQLTHLEAEL-------------------------VSGGVL 421
+ + L +K + + TL ++ + EL + L
Sbjct: 946 NAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKEL 1005
Query: 422 RDNLNFEKQKYLKFLDQLSQ-KMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENK 480
+D L+ + QKY +++ + K + D++ E+ F ++ D L V+ K
Sbjct: 1006 KDQLSEQTQKYSVSEEEVKKNKQENDKLKKEI-FTLQKD-----------LRDKTVLIEK 1053
Query: 481 TIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQK 540
+ H ++R L + + L + + L QK +++ K+ ++ + L ++NL +
Sbjct: 1054 S--HEMERALSRKTDELNKQ---LKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQ 1108
Query: 541 K-------VERLQKELN-TCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEK 592
K VE L+K LN T +L ELK+ + + + + +E+ S L +
Sbjct: 1109 KQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAE 1168
Query: 593 ---MKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKRE-- 647
+KE EK++ +K+ L E E++ E + + SE++ K++L++ E RE
Sbjct: 1169 HLQIKEAFEKEVGIIKASLREKEEESQNKMEE----VSKLQSEVQNTKQALKKLETREVV 1224
Query: 648 ---KQLADFREVVSQMLGLN 664
K A ++ +Q+ LN
Sbjct: 1225 DLSKYKATKSDLETQISSLN 1244
Score = 69.7 bits (169), Expect = 9e-12
Identities = 115/591 (19%), Positives = 242/591 (40%), Gaps = 77/591 (13%)
Query: 86 SYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVELNE 145
SY EN K L ++R + +++ L A E + +K+ E +
Sbjct: 435 SYSENEILKKEL-EAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIK 493
Query: 146 KLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERN-DKASDEDLILKLRDLRKEN 204
+L+ K+ ++ + ++ + L++ L + + + E+L +L+DL+ +
Sbjct: 494 QLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKY 553
Query: 205 EFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLLSAV 264
E ++ L I +EM + + +L E R QK+ + C E+EK + +
Sbjct: 554 EGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEME 613
Query: 265 -EAKE-ALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQ 322
+AKE + + + I E+ + + + EV+ K E+E+ + S + + +
Sbjct: 614 GQAKELSAKLALSIPAEKF---ENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRE 670
Query: 323 YFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGK 382
+ + K+A + E +++ S+LE + EL +++ +
Sbjct: 671 LENVKAKLA-----------------------QHVKPEEHEQVKSRLEQKSGELGKKITE 707
Query: 383 ESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQK 442
+ +Q + +K + L+ Q +L E+ + V K+ + +D L++K
Sbjct: 708 LTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRK 767
Query: 443 MKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKEL 502
+ LDV TE+ + +E ++EN +++ ++ R L+T E E
Sbjct: 768 L--------------LDVTQKYTEKKLEME-KLLLENDSLSKDVSR-LETVFVPPEKHEK 811
Query: 503 HMSLLRQKIAQLEEE-KQARTALVVERDNAHLTI---RNLQKKVERLQKELNTCRDLHTE 558
+ L+ I +L+++ + + +++ H NL+K + + T ++
Sbjct: 812 EIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMT 871
Query: 559 LKAKLADTNELKIKTLEQTKAIEDLN----KSRDQLEKMKEKAEKKLMSVKSE-LDTTEH 613
L LA TN + L+ K ED+N K +D+ E +K E +K+E + EH
Sbjct: 872 LNDTLAKTNR---ELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEH 928
Query: 614 EAK-------------------ENKERARNMIEVVTSEMKTLKKSLEEAEK 645
EAK N + + I + +E+K KK L+ ++
Sbjct: 929 EAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQE 979
Score = 67.4 bits (163), Expect = 4e-11
Identities = 107/470 (22%), Positives = 190/470 (40%), Gaps = 91/470 (19%)
Query: 28 VPV-TREQLNHYRN-VAQNARSELAATLVKFECAQSELQDLRSK----MLSKEVSCQELK 81
VPV T E++ N EL KFE E ++ K + E + ++K
Sbjct: 860 VPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIK 919
Query: 82 AEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIK---------- 131
AE S E+ A+ SSL S+R +VQ+ E A +T HA IK
Sbjct: 920 AEYISLAEHEAKMSSLSQSMR-KVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQ 978
Query: 132 -------------ENQELKKKVVE------LNEKLQKCSKENEENKKQVSKNCRKHEEFL 172
E E K K E L+E+ QK S EE KK +N + +E
Sbjct: 979 ECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIF 1038
Query: 173 TQLRDCLDPDERNDKASD---------EDLILKLRDL-------------------RKEN 204
T +D D +K+ + ++L +L+DL ++ +
Sbjct: 1039 TLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTS 1098
Query: 205 EFVKGQIVILEETINVHEMEA--KASRETIMRLASEVNREQK----------KAASCTEE 252
E + Q ++ ++ + + ++EA K+ TI L E+ Q+ K E
Sbjct: 1099 EILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLEN 1158
Query: 253 KEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLK-- 310
++ + L ++ KEA E+EV I + L ++ +EVS L+ +++LK
Sbjct: 1159 QKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKL 1218
Query: 311 ASQDAVTTS---------QSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREES 361
+++ V S ++Q S EK+A L R E+ + K +E+ +++E
Sbjct: 1219 ETREVVDLSKYKATKSDLETQISSLNEKLANLNR---KYEEVCEEVLHAKKKEISAKDE- 1274
Query: 362 RDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHL 411
++ + +E +I + E+ K + +R Q++ +E ++T L
Sbjct: 1275 KELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITEL 1324
Score = 67.0 bits (162), Expect = 6e-11
Identities = 141/600 (23%), Positives = 242/600 (40%), Gaps = 109/600 (18%)
Query: 102 RDRVQELEEESAALST-SKIRTEITAHAAIKENQELKKKVVELNEKLQKCSKENEENKKQ 160
RD V+ L + A +S + + + +A I +N +++ L+ S+ + ++
Sbjct: 213 RDAVEVLIKNGADISLLDALGHDSSYYARIGDN-------LDILTLLKTASENTNKGREL 265
Query: 161 VSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRKENEFVKGQIVILEETINV 220
K + LT ++D E N K+ + ++DL ENE +K E +
Sbjct: 266 WKKGPSLQQRNLTHMQD-----EVNVKSHQREH-QNIQDLEIENEDLK-------ERLRK 312
Query: 221 HEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLLSAVEAK--------EALER 272
+ E + + + L ++N E A E+EKL + LL+A E + EAL+
Sbjct: 313 IQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKL-KSLLAAKEKQHEESLRTIEALKN 371
Query: 273 EVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAA 332
K F+ L G ++++E LLK+ + S S QS R +
Sbjct: 372 RFKYFESDHL-GSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQS-----RSMLRP 425
Query: 333 LLRGRLSMTGSTEDTILEKIRE-----MDSREESRDRMVSQLEAQISELVEQLGKESGFH 387
L S T +E+ IL+K E +S ++ R ++ ++L +++E
Sbjct: 426 LELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAEC----------- 474
Query: 388 QKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQ 447
KAL A + E + E Q+ LE L + +K+ Y + K+ Q
Sbjct: 475 -KAL--ALECERVKEDSDEQIKQLEDAL---------KDVQKRMY-------ESEGKVKQ 515
Query: 448 MAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMSLL 507
M LA E L S A N + L+ +LK K + E + L
Sbjct: 516 MQTHF---------LALKEHLT---SEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKL 563
Query: 508 RQKIAQLEEEKQARTALVVE---RDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLA 564
R +I Q E ++VE RD L N +RLQKEL+ C ++ E K +
Sbjct: 564 RNQIKQNE--------MIVEEFKRDEGKLIEEN-----KRLQKELSMC-EMEREKKGRKV 609
Query: 565 DTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARN 624
E + K L A L+ ++ E MK ++ +L E E E++ +
Sbjct: 610 TEMEGQAKELSAKLA---LSIPAEKFENMKSSLSNEVNEKAKKLVEMERE----HEKSLS 662
Query: 625 MIEVVTSEMKTLKKSLEEAEKRE--KQLADFREVVSQMLGLNVTSLALPDYEIIKCLERL 682
I + E++ +K L + K E +Q+ E S LG +T L L + + K +E++
Sbjct: 663 EIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKV 722
Score = 36.2 bits (82), Expect = 0.11
Identities = 45/236 (19%), Positives = 96/236 (40%), Gaps = 42/236 (17%)
Query: 80 LKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKK 139
+KA + +E + K ++ L+ VQ ++ L T ++ +++ + A K +L+ +
Sbjct: 1183 IKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREV-VDLSKYKATKS--DLETQ 1239
Query: 140 VVELNEKLQKCSKENEE--------NKKQVS--------------------KNCRKHEEF 171
+ LNEKL +++ EE KK++S + C K
Sbjct: 1240 ISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTT 1299
Query: 172 LTQLRDCLDPDERNDKASDEDLILKLRDLRKENEFVKGQIVILEETINVHEMEAKASRET 231
+T+L+ + + +A D + L D+ + + + G L + K +
Sbjct: 1300 ITELQRRIQESAKQIEAKDNKITELLNDVERLKQALNG----LSQLTYTSGNPTKRQSQL 1355
Query: 232 IMRLASEVNREQKKAASCTEEKEKL----NQDLLSAVEA---KEALEREVKIFQER 280
I L +V +++ A + +++ LLSA + ++ E ++I Q R
Sbjct: 1356 IDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQMR 1411
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 100 bits (249), Expect = 5e-21
Identities = 123/612 (20%), Positives = 270/612 (44%), Gaps = 67/612 (10%)
Query: 79 ELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAA--------- 129
E + EM S KE R L R +ELEE+ +L K ++ A
Sbjct: 844 EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEE 903
Query: 130 -----IKENQELKKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDER 184
IK +L+ KV E+NE+L+ + EE +++ RK E+ ++L+ +D
Sbjct: 904 RCDQLIKNKIQLEAKVKEMNERLE----DEEEMNAELTAKKRKLEDECSELKRDID---- 955
Query: 185 NDKASDEDLILKLRDLRKENEFVKGQIV-ILEETINVHEM------EAKASRETIMRLAS 237
DL L L + KE + ++ + EE + E+ E KA +E +
Sbjct: 956 -------DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD 1008
Query: 238 EVNREQKKAASCTEEKEKLNQ---DLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQE 294
++ E+ K + T+ K KL Q DL ++E ++ + +++ + +L ++ +++
Sbjct: 1009 DLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKL---TQES 1065
Query: 295 VSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIRE 354
+ L+ +L++ LK +D + + + + + L+ +L + + + E++
Sbjct: 1066 IMDLENDKQQLDERLK-KKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEA 1124
Query: 355 MDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAE 414
+ +++ S L ++ E+ E+L + G ++ +K E + ++ L EA
Sbjct: 1125 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE--EAT 1182
Query: 415 L---VSGGVLRDNLNFEKQKYLKFLDQLSQ-KMKLDQMAAELGFDMRLDVVLARTEQLVR 470
L + LR + + +D L + K KL++ +E F + LD V + EQ+++
Sbjct: 1183 LQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE--FKLELDDVTSNMEQIIK 1240
Query: 471 LESNAVIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEK-------QARTA 523
++N + + L+ ++ + + E + ++ L + A+L+ E + A
Sbjct: 1241 AKANL----EKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEA 1296
Query: 524 LVVERDNAHLT-IRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIED 582
L+ + LT + L+ +L++E+ L L++ D + L+ + E+T+A +
Sbjct: 1297 LISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAE 1356
Query: 583 ----LNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKK 638
L+K+ ++ + + K E + EL+ + + + + A +E V ++ +L+K
Sbjct: 1357 LQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEK 1416
Query: 639 SLEEAEKREKQL 650
+ + + L
Sbjct: 1417 TKHRLQNEIEDL 1428
Score = 98.2 bits (243), Expect = 2e-20
Identities = 146/704 (20%), Positives = 298/704 (42%), Gaps = 95/704 (13%)
Query: 24 HLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAE 83
H V EQ+++ + V Q E + ++ + S ++ + + E C+ L+ +
Sbjct: 1196 HADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQ 1255
Query: 84 MESYK---ENNARKSSLLTSLRDRVQ----ELE---EESAALSTSKIRTEITAHAAIKE- 132
M ++ E R + LTS R ++Q EL +E AL + R ++T +++
Sbjct: 1256 MNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDL 1315
Query: 133 NQELKKKVVELN-------------EKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCL 179
++L+++V N + L++ +E E K ++ + K + Q R
Sbjct: 1316 KRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKY 1375
Query: 180 DPD--ERNDKASD--EDLILKLRDLRKENEFVKGQIVILEET------------INVHEM 223
+ D +R ++ + + L +L++ + E V + LE+T ++V
Sbjct: 1376 ETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERS 1435
Query: 224 EAKAS----------------RETIMRLASEVNREQKKAASCTEEKEKLNQDLLSAVEAK 267
A A+ ++ SE+ QK+A S + E KL ++E
Sbjct: 1436 NAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHL 1495
Query: 268 EALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFR 327
E +RE K QE + + +S + + L+K +LE Q A+ +++ S
Sbjct: 1496 ETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEA---SLE 1552
Query: 328 EKIAALLRGRLSMT---GSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKES 384
+ +LR +L E + EK EM+ + + R+V L+ L E+
Sbjct: 1553 HEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTS-------LDAET 1605
Query: 385 GFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQ--K 442
+AL+ +K E L ++ QL+H + + E QK +K L L + +
Sbjct: 1606 RSRNEALRVKKKMEGDLNEMEIQLSHA-----------NRMAAEAQKQVKSLQSLLKDTQ 1654
Query: 443 MKLDQMAAELGFDMRLDV-VLARTEQLVRLESNAVIENKTIAHNLQRKLK-TQKERLESK 500
++LD A D++ ++ ++ R L++ E E + + +R K ++E +E+
Sbjct: 1655 IQLDD-AVRANDDLKENIAIVERRNNLLQAELE---ELRAVVEQTERSRKLAEQELIETS 1710
Query: 501 ELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELK 560
E L Q + + ++K+ L + ++ + E+ +K + + ELK
Sbjct: 1711 ERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELK 1770
Query: 561 AKLADTN---ELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKK-LMSVKSELDTTEHEAK 616
K DT+ E K +EQT I+DL D+ E++ K KK L +++ + E+E +
Sbjct: 1771 -KEQDTSAHLERMKKNMEQT--IKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELE 1827
Query: 617 ENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREVVSQM 660
++R ++ + + +K+ + E+ K L +++V ++
Sbjct: 1828 AEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKL 1871
Score = 93.6 bits (231), Expect = 6e-19
Identities = 131/652 (20%), Positives = 271/652 (41%), Gaps = 90/652 (13%)
Query: 59 AQSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTS 118
A+ L + E +E+ +E +E NA ++ L D EL+ + L +
Sbjct: 901 AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELT 960
Query: 119 KIRTEITAHAAIKENQELKKKVVELNEKLQKCSKEN---EENKKQVSKNCRKHEE---FL 172
+ E HA + + L +++ L+E + K +KE +E +Q + + E+ L
Sbjct: 961 LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTL 1020
Query: 173 TQLRDCLDPDERNDKASDEDLILKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETI 232
T+ + L+ + + S E DL + ++G + + +E+I E + + E +
Sbjct: 1021 TKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERL 1080
Query: 233 MRLASEVN--------------REQKKAASCTEEKEKLNQDLLSAVEAKEALE------- 271
+ E+N + QKK E+L ++L + A+ +E
Sbjct: 1081 KKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLS 1140
Query: 272 REVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIA 331
RE++ ERL ++ A+ ++ + KK +E +K + ++A ++ + R+K A
Sbjct: 1141 RELEEISERL---EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHA 1197
Query: 332 ALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKAL 391
+ + E+ + ++ R+ +LE + SE +L + ++ +
Sbjct: 1198 ------------------DSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII 1239
Query: 392 QRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAE 451
+ E M TL+ Q+ ++ E Q+ + D SQ+ KL E
Sbjct: 1240 KAKANLEKMCRTLEDQMNEHRSKAE-----------ETQRSVN--DLTSQRAKLQTENGE 1286
Query: 452 LGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQK---ERLESKELHMSLLR 508
L +LD A QL R + + + + L+ ++K + L+S LLR
Sbjct: 1287 L--SRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLR 1344
Query: 509 QKIAQLEEEKQARTAL--VVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADT 566
+ Q EEE +A+ L V+ + N+ + + + + +Q+ + +L +L +
Sbjct: 1345 E---QYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQR-TEELEEAKKKLAQRLQEA 1400
Query: 567 NE------LKIKTLEQTK-----AIEDL-------NKSRDQLEKMKEKAEKKLMSVKSEL 608
E K +LE+TK IEDL N + L+K + +K L K +
Sbjct: 1401 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKY 1460
Query: 609 DTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREVVSQM 660
+ ++ E + +++ AR++ + ++SLE E +++ + +E +S +
Sbjct: 1461 EESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDL 1512
Score = 92.8 bits (229), Expect = 1e-18
Identities = 145/693 (20%), Positives = 296/693 (42%), Gaps = 111/693 (16%)
Query: 60 QSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSK 119
+++ Q L ++ K+ L A +E + ++ L L+ R++ELEEE A T++
Sbjct: 1070 ENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTAR 1129
Query: 120 IRTEITAHAAIKENQELKKKV----------VELNEK----LQKCSKENEENKKQVSKNC 165
+ E +E +E+ +++ +E+N+K QK ++ EE Q
Sbjct: 1130 AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATA 1189
Query: 166 ----RKHEEFLTQL----------RDCLDPDERNDKASDEDLILKLRDLRKENEFVKGQI 211
+KH + + +L + L+ ++ K +D+ + + K ++
Sbjct: 1190 AALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMC 1249
Query: 212 VILEETINVHEMEAKASRETIMRLASE---VNREQKKAASCTEEKEKLNQDL----LSAV 264
LE+ +N H +A+ ++ ++ L S+ + E + + +EKE L L L+
Sbjct: 1250 RTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYT 1309
Query: 265 EAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYF 324
+ E L+R+++ + A +++ + LL++ E ++ Q ++ + S+
Sbjct: 1310 QQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVA 1369
Query: 325 SFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKES 384
+R K + I+ + EE++ ++ +L+ + E VE + +
Sbjct: 1370 QWRTKYET-----------------DAIQRTEELEEAKKKLAQRLQ-EAEEAVEAVNAKC 1411
Query: 385 GFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFE------KQKYLKFLDQ 438
+K R Q N +E L + A + + + NF+ KQKY + +
Sbjct: 1412 SSLEKTKHRLQ---NEIEDLMVDVERSNA--AAAALDKKQRNFDKILAEWKQKYEESQSE 1466
Query: 439 LSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLE 498
L K + + F ++ A E L LE+ ENK NLQ ++ E+L
Sbjct: 1467 LESSQKEARSLSTELFKLK----NAYEESLEHLET-FKRENK----NLQEEISDLTEQLG 1517
Query: 499 SKELHMSLLRQKIAQLEEEK-QARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHT 557
S + L + QLE EK + ++AL + A ++ + + K+ R Q E N +
Sbjct: 1518 SSGKTIHELEKVRKQLEAEKMELQSAL----EEAEASLEHEEGKILRAQLEFN---QIKA 1570
Query: 558 ELKAKLAD---------TNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSEL 608
E++ KLA+ N L++ QT +++ +SR++ ++K+K E L ++ +L
Sbjct: 1571 EIERKLAEKDEEMEQAKRNHLRVVDSLQT-SLDAETRSRNEALRVKKKMEGDLNEMEIQL 1629
Query: 609 DTTEHEAKENKERARNM----------IEVVTSEMKTLKKSLEEAEKR----EKQLADFR 654
A E +++ +++ ++ LK+++ E+R + +L + R
Sbjct: 1630 SHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR 1689
Query: 655 EVVSQMLGLNVTSLALPDYEIIKCLER--LVHS 685
VV Q S L + E+I+ ER L+HS
Sbjct: 1690 AVVEQ----TERSRKLAEQELIETSERVQLLHS 1718
Score = 57.8 bits (138), Expect = 3e-08
Identities = 89/426 (20%), Positives = 166/426 (38%), Gaps = 39/426 (9%)
Query: 19 EETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQ 78
EE D ++ + + ++ V + +E E A++ L+ K+L ++
Sbjct: 1507 EEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFN 1566
Query: 79 ELKA-----------EMESYKENNAR-KSSLLTSL----RDRVQ----------ELEEES 112
++KA EME K N+ R SL TSL R R + +L E
Sbjct: 1567 QIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME 1626
Query: 113 AALSTSKIRTEITAHAAIKENQELKKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFL 172
LS + R A +K Q L K + + + + +EN V + + L
Sbjct: 1627 IQLSHAN-RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAEL 1685
Query: 173 TQLRDCLDPDERNDKASDEDLI---LKLRDLRKENEFVKGQIVILEETINVHEMEAKASR 229
+LR ++ ER+ K ++++LI +++ L +N + Q ++ ++ + E + +
Sbjct: 1686 EELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAV 1745
Query: 230 ETIMRLASEVNREQKKAASCTEEKEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQV-W 288
+ + + AA EE +K K+ +E+ +K Q RL +Q+
Sbjct: 1746 QECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAL 1805
Query: 289 DASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTI 348
K+++ L+ ELE L+A Q S +I L T TE+
Sbjct: 1806 KGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKEL-------TYQTEEDR 1858
Query: 349 LEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQL 408
+R D ++ + + V + Q E EQ +K +AE + + Q+
Sbjct: 1859 KNLLRLQDLVDKLQLK-VKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQV 1917
Query: 409 THLEAE 414
L A+
Sbjct: 1918 NKLRAK 1923
Score = 49.7 bits (117), Expect = 1e-05
Identities = 62/276 (22%), Positives = 126/276 (45%), Gaps = 44/276 (15%)
Query: 386 FHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKL 445
F K L ++ + E + +++ + T L+ L R L + L+ + L +++
Sbjct: 834 FKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA 893
Query: 446 DQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMS 505
+Q LA E+ + +I+NK L+ K+K ERLE +E +
Sbjct: 894 EQDN------------LADAEE----RCDQLIKNKI---QLEAKVKEMNERLEDEEEMNA 934
Query: 506 LLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLAD 565
L K +LE+E ++RD I +L+ + +++KE + + L ++A
Sbjct: 935 ELTAKKRKLEDECSE-----LKRD-----IDDLELTLAKVEKEKHATENKVKNLTEEMAG 984
Query: 566 TNELKIKTLEQTK--------AIEDLNKSRDQ---LEKMKEKAEKKLMSVKSELDTTEHE 614
+E+ K ++ K A++DL D+ L K K K E+++ ++ L+ E +
Sbjct: 985 LDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLE-QEKK 1043
Query: 615 AKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQL 650
+ + ERA+ +E ++K ++S+ + E ++QL
Sbjct: 1044 VRMDLERAKRKLE---GDLKLTQESIMDLENDKQQL 1076
Score = 44.7 bits (104), Expect = 3e-04
Identities = 64/321 (19%), Positives = 132/321 (41%), Gaps = 38/321 (11%)
Query: 14 ASPAPEETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSK 73
A+ A ++ S + T+ QL+ + + +A + Q+EL++LR
Sbjct: 1636 AAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR------ 1689
Query: 74 EVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKEN 133
A +E + + L +RVQ L ++ +L K K +
Sbjct: 1690 --------AVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQK----------KKMD 1731
Query: 134 QELKKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDL 193
+L + E+ E +Q+C E+ KK ++ EE L + +D ER K + E
Sbjct: 1732 ADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEE-LKKEQDTSAHLERM-KKNMEQT 1789
Query: 194 ILKLRDLRKENEFV-----KGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAAS 248
I L+ E E + K Q+ LE + E E +A ++ + + +++
Sbjct: 1790 IKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKE 1849
Query: 249 CTEEKEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKS 308
T + E+ ++LL + + L+ +VK ++ + ++ + + +S +K EL++
Sbjct: 1850 LTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQ---AEEAEEQANTNLSKFRKVQHELDE- 1905
Query: 309 LKASQDAVTTSQSQYFSFREK 329
+++ ++SQ R K
Sbjct: 1906 ---AEERADIAESQVNKLRAK 1923
Score = 35.8 bits (81), Expect = 0.14
Identities = 28/130 (21%), Positives = 59/130 (45%), Gaps = 12/130 (9%)
Query: 543 ERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLM 602
E L+K ++L ++ + L + N+L+++ + + D + DQL K K + E K+
Sbjct: 861 EALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVK 920
Query: 603 SVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAE------KREKQLAD--FR 654
+ L+ E E + R + E LK+ +++ E ++EK + +
Sbjct: 921 EMNERLEDEEEMNAELTAKKRKL----EDECSELKRDIDDLELTLAKVEKEKHATENKVK 976
Query: 655 EVVSQMLGLN 664
+ +M GL+
Sbjct: 977 NLTEEMAGLD 986
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 100 bits (248), Expect = 6e-21
Identities = 170/760 (22%), Positives = 314/760 (41%), Gaps = 135/760 (17%)
Query: 25 LSEVPVTREQLNHYRNVAQNARSELAATL-VKFECAQSELQDL--RSKMLSKEVSCQELK 81
L E+ +E+L R Q + L + E Q E++ L ++ LSKE + LK
Sbjct: 503 LQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKEN--ESLK 560
Query: 82 AEMESYKENNAR-----KSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQEL 136
+++E + N+ KS L T++ Q +EE + S + TE A +K ++
Sbjct: 561 SKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKG-LGTETAEFAELKT--QI 617
Query: 137 KKKVVELNEKLQKC-----------SKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERN 185
+K ++ +++ +KE E + ++ K ++ E L +R LD E
Sbjct: 618 EKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQ 677
Query: 186 DKASDEDLILKLRDLR---KENEFVKGQIVILEETINVHEMEAKASRETIMRL------A 236
ED + KL++ KE E ++ + + I+ + KA+ E ++ L +
Sbjct: 678 HLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKAS 737
Query: 237 SEVNREQKKAASCTEEKEKLNQDLLSAVEA---------KEALEREVKI--FQERLLAGQ 285
SE E KK E EK + L A +E RE+K+ QE L
Sbjct: 738 SEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVS 797
Query: 286 QVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSF-----REKIAALLRGRLSM 340
QV + ++E+ +LK EK +AS++AV+ +S + +E+ +L L
Sbjct: 798 QVKETLEKELQILK------EKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEK 851
Query: 341 TGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENM 400
+ K RE D REE + +LE I+E+++ G S K + E
Sbjct: 852 LRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERD 911
Query: 401 LETLQGQLTHLE--AELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRL 458
+E LQ +LT A + + + E+ + +K +L++ ++L + ++
Sbjct: 912 VEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL--EKKM 969
Query: 459 DVVLARTEQLVRLESNAVIENKT----IAHNLQRKLKTQKERLE-SKELHMSLLRQ---- 509
+ + ++L A E KT I NLQ+ L +++L+ ++E + LL++
Sbjct: 970 ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL 1029
Query: 510 -----------------------------KIAQLEEEKQARTALVVERDNAH-------- 532
+A LE+ KQ L E D
Sbjct: 1030 RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE 1089
Query: 533 --------LTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLN 584
LT+ N +K+E +KE+ T + + +L+ E E K E+L
Sbjct: 1090 ELNKSKELLTVEN--QKMEEFRKEIETLKQAAAQKSQQLSALQE------ENVKLAEELG 1141
Query: 585 KSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAE 644
+SRD++ + +KL +S L+ ++ E K+R I+ E +L+KS+
Sbjct: 1142 RSRDEV-----TSHQKLEEERSVLN---NQLLEMKKRESKFIKDADEEKASLQKSISITS 1193
Query: 645 ----KREKQLADFREVVSQMLGLNVTSLALPDYEIIKCLE 680
+++ +L R V+ + G N ++ +L + +++ LE
Sbjct: 1194 ALLTEKDAELEKLRNEVTVLRGENASAKSL--HSVVQTLE 1231
Score = 76.6 bits (187), Expect = 7e-14
Identities = 146/722 (20%), Positives = 276/722 (38%), Gaps = 140/722 (19%)
Query: 60 QSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSK 119
+S + +L + + EL+ +ES K SL SL + L+E+ T
Sbjct: 463 KSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSL--SLLQEISSLQEKLEVTRTDH 520
Query: 120 IR--TEITAHAAIKENQELKKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRD 177
R T + H +E +K++ L +K SKENE K ++ +++ + + +
Sbjct: 521 QREITSLKEHFGAREETH-QKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKS 579
Query: 178 CLDPDERNDKASDEDL---------------------ILKLR-DLRKENEFVKGQIVILE 215
L+ + + + E+L I K+R D + E E ++ Q +
Sbjct: 580 KLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQ---QD 636
Query: 216 ETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLN----QDLLSAVEAKEALE 271
H E +A R +M++ E + S ++ E + +D L+ ++ E
Sbjct: 637 SERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKV 696
Query: 272 REVKIFQ---------------------ERLLAGQQVWDASKQEVSLLKKSSSELE---- 306
+E+++ Q E+LL + AS + S +KK +LE
Sbjct: 697 KELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEK 756
Query: 307 -----------KSLKAS-----------------------QDAVTTSQSQYFSFREKIAA 332
+S KAS T + + +EK A
Sbjct: 757 QIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAE 816
Query: 333 LLRGRLSMTGSTEDTI----------------LEKIR-----------EMDSREESRDRM 365
+S+ S ++T+ LEK+R E D REE +
Sbjct: 817 ASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKA 876
Query: 366 VSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLT--HLEAELVSGGVLRD 423
+LE I+E+++ G S K + E +E LQ +LT + A + +
Sbjct: 877 KEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM 936
Query: 424 NLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKT-- 481
+ E+ + +K +L++ ++L + +++ + ++L A E KT
Sbjct: 937 TVKAEQSQQEAAKKHEEEKKELERKLSDL--EKKMETSHNQCQELKARYERATSETKTKH 994
Query: 482 --IAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQ 539
I NLQ+ L +++L+ S L Q++ +L ++ A D + + +
Sbjct: 995 EEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTK 1054
Query: 540 KKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEK 599
+K E L +T + AKL NEL K +E+LNKS++ L +K E+
Sbjct: 1055 EKTETLASLEDT-----KQTNAKL--QNELDTLKENNLKNVEELNKSKELLTVENQKMEE 1107
Query: 600 KLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREVVSQ 659
+ E++T + A + ++ + E + L +S +E +K L + R V++
Sbjct: 1108 ----FRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQK-LEEERSVLNN 1162
Query: 660 ML 661
L
Sbjct: 1163 QL 1164
Score = 74.7 bits (182), Expect = 3e-13
Identities = 78/360 (21%), Positives = 158/360 (43%), Gaps = 37/360 (10%)
Query: 60 QSELQDLRSKMLSKEVSCQELKAEME-SYKENNARKSSLLTSLRDRVQELEEESAALSTS 118
+ +L DL KM + CQELKA E + E + +L +L+ + + E++
Sbjct: 959 ERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDK------- 1011
Query: 119 KIRTEITAHAAIKENQELKKKVVELNEKLQKC-SKENEENKKQVSKNCRKHE-EFLTQLR 176
A +EN L +++ EL ++ K + + E+ Q+ + K + E L L
Sbjct: 1012 -------LKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLE 1064
Query: 177 DCLDPDERNDKASDEDLILKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLA 236
D + N K +E LK +L+ E K +E + V + + R+ I L
Sbjct: 1065 ---DTKQTNAKLQNELDTLKENNLKNVEELNKS-----KELLTVENQKMEEFRKEIETLK 1116
Query: 237 SEVNREQKKAASCTEEKEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVS 296
++ ++ ++ EE KL ++L +++ + K+ +ER + Q+ + K+E
Sbjct: 1117 QAAAQKSQQLSALQEENVKLAEEL---GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESK 1173
Query: 297 LLKKSSSE---LEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIR 353
+K + E L+KS+ + +T ++ R ++ +LRG ++ ++ ++
Sbjct: 1174 FIKDADEEKASLQKSISITSALLTEKDAELEKLRNEV-TVLRGE----NASAKSLHSVVQ 1228
Query: 354 EMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKA-ENMLETLQGQLTHLE 412
++S + + V LE Q+ E QL SG ++A E+ ++ L + L+
Sbjct: 1229 TLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQ 1288
Score = 73.2 bits (178), Expect = 8e-13
Identities = 123/568 (21%), Positives = 239/568 (42%), Gaps = 50/568 (8%)
Query: 23 DHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKA 82
++LSEV +E L + + +E + V Q +Q+ +K+ KE L +
Sbjct: 791 ENLSEVSQVKETLEKELQILKEKFAEASEEAVS---VQRSMQETVNKLHQKEEQFNMLSS 847
Query: 83 EMESYKENNARKSSLLTSLRDRVQELEEESAALST------------SKIRTEITAHAAI 130
++E +EN A + +R ++L + L S T++ +
Sbjct: 848 DLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRL 907
Query: 131 KEN--QELKKKVVELNEKLQKCSKENEENKKQVSKN----CRKHEEFLTQL-RDCLDPDE 183
KE +EL+ K+ + NE K E+ + ++ +KHEE +L R D ++
Sbjct: 908 KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEK 967
Query: 184 RNDKASDEDLILKLRDLRKENEF-VKGQIVI--LEETINVHEMEAKASRETIMRLASEVN 240
+ + + ++ LK R R +E K + ++ L++T+ E + K +RE L E+
Sbjct: 968 KMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELE 1027
Query: 241 REQKKAASCTEEKEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKK 300
+K+A +K K Q A++ E + +E L +Q + E+ LK+
Sbjct: 1028 ELRKQA-----DKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1082
Query: 301 SSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREE 360
++ + + L S++ +T + FR++I L + + E ++ +
Sbjct: 1083 NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGR 1142
Query: 361 SRDRMVS--QLEAQIS----ELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAE 414
SRD + S +LE + S +L+E +ES F + A + + + LT +AE
Sbjct: 1143 SRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAE 1202
Query: 415 LVSGGVLRDNLNF--EKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLE 472
L LR+ + + K L + Q ++ D++ EL L++ L ++ +
Sbjct: 1203 LEK---LRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKV-KNLELQLKENKRQLSSS 1258
Query: 473 SNAVIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAH 532
S T A +R ++Q + L S + + Q + +++ E + AL D+ +
Sbjct: 1259 SG---NTDTQADEDERAQESQIDFLNSVIVDLQRKNQDL-KMKVEMMSEAALNGNGDDLN 1314
Query: 533 LTIRNLQ----KKVERLQKELNTCRDLH 556
+ Q KK RL ++ C DLH
Sbjct: 1315 NYDSDDQEKQSKKKPRLFCDICDCFDLH 1342
Score = 60.1 bits (144), Expect = 7e-09
Identities = 94/451 (20%), Positives = 175/451 (38%), Gaps = 84/451 (18%)
Query: 207 VKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLLSAVEA 266
++ ++ + + + H +E +A + + + +RE+ + + EE+++ +DL VE
Sbjct: 388 IEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEE 447
Query: 267 KEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSF 326
+ + ++++ A+ E K ELEK L +
Sbjct: 448 ESITKGDLEV-------------ATVSE----KSRIMELEKDL---------------AL 475
Query: 327 REKIAALLRGRL--SMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKES 384
R + A LR RL + D L ++E+ S +E + + + +I+ L E G
Sbjct: 476 RVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGARE 535
Query: 385 GFHQKALQRAQKAENML----ETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLS 440
HQK ++ A L E+L+ +L H E D + K K +
Sbjct: 536 ETHQKEIKALYTATEKLSKENESLKSKLEHANKE------NSDVIALWKSKLETAIASHQ 589
Query: 441 QKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESK 500
Q M+ +++ G T + L++ H ++ Q +
Sbjct: 590 QAMEELKVSFSKGLG-------TETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAH 642
Query: 501 ELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRN-LQKKVERLQKELNTCRDLHTEL 559
M LR K+ + ++ E++N+ IR+ L K ++ E+ + E
Sbjct: 643 AKEMEALRAKLMK----------VIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEA 692
Query: 560 KAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENK 619
+ K+ + L+ K EQTK I++ ++K EK L +LD + E K
Sbjct: 693 EIKVKELEVLQAKCNEQTKVIDNFT------SQLKATEEKLL-----DLDALRKASSEGK 741
Query: 620 ERARNMIEVVTSEMKTLKKSLEEAEKREKQL 650
SEMK L++ LE AEK+ K L
Sbjct: 742 -----------SEMKKLRQQLEAAEKQIKHL 761
Score = 35.8 bits (81), Expect = 0.14
Identities = 35/161 (21%), Positives = 72/161 (44%), Gaps = 9/161 (5%)
Query: 514 LEEEKQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLH----TELKAKLADTNEL 569
L+E++Q L+ ERD + V +++EL RD H EL+AK+ +
Sbjct: 357 LKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTM 416
Query: 570 -KIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEV 628
+ E+ + + L + + ++E ++ + E++ ++ K +L+ K + +
Sbjct: 417 VEAADREKVELLNQLEEEKRKVEDLQFRVEEESIT-KGDLEVATVSEKSRIMELEKDLAL 475
Query: 629 VTSEMKTLKKSLEE---AEKREKQLADFREVVSQMLGLNVT 666
E+ L++ LE A + L+ +E+ S L VT
Sbjct: 476 RVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVT 516
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 100 bits (248), Expect = 6e-21
Identities = 170/760 (22%), Positives = 314/760 (41%), Gaps = 135/760 (17%)
Query: 25 LSEVPVTREQLNHYRNVAQNARSELAATL-VKFECAQSELQDL--RSKMLSKEVSCQELK 81
L E+ +E+L R Q + L + E Q E++ L ++ LSKE + LK
Sbjct: 538 LQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKEN--ESLK 595
Query: 82 AEMESYKENNAR-----KSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQEL 136
+++E + N+ KS L T++ Q +EE + S + TE A +K ++
Sbjct: 596 SKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKG-LGTETAEFAELKT--QI 652
Query: 137 KKKVVELNEKLQKC-----------SKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERN 185
+K ++ +++ +KE E + ++ K ++ E L +R LD E
Sbjct: 653 EKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQ 712
Query: 186 DKASDEDLILKLRDLR---KENEFVKGQIVILEETINVHEMEAKASRETIMRL------A 236
ED + KL++ KE E ++ + + I+ + KA+ E ++ L +
Sbjct: 713 HLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKAS 772
Query: 237 SEVNREQKKAASCTEEKEKLNQDLLSAVEA---------KEALEREVKI--FQERLLAGQ 285
SE E KK E EK + L A +E RE+K+ QE L
Sbjct: 773 SEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVS 832
Query: 286 QVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSF-----REKIAALLRGRLSM 340
QV + ++E+ +LK EK +AS++AV+ +S + +E+ +L L
Sbjct: 833 QVKETLEKELQILK------EKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEK 886
Query: 341 TGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENM 400
+ K RE D REE + +LE I+E+++ G S K + E
Sbjct: 887 LRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERD 946
Query: 401 LETLQGQLTHLE--AELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRL 458
+E LQ +LT A + + + E+ + +K +L++ ++L + ++
Sbjct: 947 VEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL--EKKM 1004
Query: 459 DVVLARTEQLVRLESNAVIENKT----IAHNLQRKLKTQKERLE-SKELHMSLLRQ---- 509
+ + ++L A E KT I NLQ+ L +++L+ ++E + LL++
Sbjct: 1005 ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL 1064
Query: 510 -----------------------------KIAQLEEEKQARTALVVERDNAH-------- 532
+A LE+ KQ L E D
Sbjct: 1065 RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE 1124
Query: 533 --------LTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLN 584
LT+ N +K+E +KE+ T + + +L+ E E K E+L
Sbjct: 1125 ELNKSKELLTVEN--QKMEEFRKEIETLKQAAAQKSQQLSALQE------ENVKLAEELG 1176
Query: 585 KSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAE 644
+SRD++ + +KL +S L+ ++ E K+R I+ E +L+KS+
Sbjct: 1177 RSRDEV-----TSHQKLEEERSVLN---NQLLEMKKRESKFIKDADEEKASLQKSISITS 1228
Query: 645 ----KREKQLADFREVVSQMLGLNVTSLALPDYEIIKCLE 680
+++ +L R V+ + G N ++ +L + +++ LE
Sbjct: 1229 ALLTEKDAELEKLRNEVTVLRGENASAKSL--HSVVQTLE 1266
Score = 80.1 bits (196), Expect = 7e-15
Identities = 151/740 (20%), Positives = 282/740 (38%), Gaps = 140/740 (18%)
Query: 42 AQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSL 101
A + EL T V +S + +L + + EL+ +ES K SL SL
Sbjct: 480 ADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSL--SL 537
Query: 102 RDRVQELEEESAALSTSKIR--TEITAHAAIKENQELKKKVVELNEKLQKCSKENEENKK 159
+ L+E+ T R T + H +E +K++ L +K SKENE K
Sbjct: 538 LQEISSLQEKLEVTRTDHQREITSLKEHFGAREETH-QKEIKALYTATEKLSKENESLKS 596
Query: 160 QVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDL---------------------ILKLR 198
++ +++ + + + L+ + + + E+L I K+R
Sbjct: 597 KLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMR 656
Query: 199 -DLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLN 257
D + E E ++ Q + H E +A R +M++ E + S ++ E +
Sbjct: 657 LDYQHEIENLQNQ---QDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQH 713
Query: 258 ----QDLLSAVEAKEALEREVKIFQ---------------------ERLLAGQQVWDASK 292
+D L+ ++ E +E+++ Q E+LL + AS
Sbjct: 714 LVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASS 773
Query: 293 QEVSLLKKSSSELE---------------KSLKAS-----------------------QD 314
+ S +KK +LE +S KAS
Sbjct: 774 EGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ 833
Query: 315 AVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTI----------------LEKIR----- 353
T + + +EK A +S+ S ++T+ LEK+R
Sbjct: 834 VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLAD 893
Query: 354 ------EMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQ 407
E D REE + +LE I+E+++ G S K + E +E LQ +
Sbjct: 894 MEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLK 953
Query: 408 LT--HLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLART 465
LT + A + + + E+ + +K +L++ ++L + +++ +
Sbjct: 954 LTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL--EKKMETSHNQC 1011
Query: 466 EQLVRLESNAVIENKT----IAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQAR 521
++L A E KT I NLQ+ L +++L+ S L Q++ +L ++
Sbjct: 1012 QELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKA 1071
Query: 522 TALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIE 581
A D + + ++K E L +T + AKL NEL K +E
Sbjct: 1072 KAAQTAEDAMQIMEQMTKEKTETLASLEDT-----KQTNAKL--QNELDTLKENNLKNVE 1124
Query: 582 DLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLE 641
+LNKS++ L +K E+ + E++T + A + ++ + E + L +S +
Sbjct: 1125 ELNKSKELLTVENQKMEE----FRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1180
Query: 642 EAEKREKQLADFREVVSQML 661
E +K L + R V++ L
Sbjct: 1181 EVTSHQK-LEEERSVLNNQL 1199
Score = 74.7 bits (182), Expect = 3e-13
Identities = 78/360 (21%), Positives = 158/360 (43%), Gaps = 37/360 (10%)
Query: 60 QSELQDLRSKMLSKEVSCQELKAEME-SYKENNARKSSLLTSLRDRVQELEEESAALSTS 118
+ +L DL KM + CQELKA E + E + +L +L+ + + E++
Sbjct: 994 ERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDK------- 1046
Query: 119 KIRTEITAHAAIKENQELKKKVVELNEKLQKC-SKENEENKKQVSKNCRKHE-EFLTQLR 176
A +EN L +++ EL ++ K + + E+ Q+ + K + E L L
Sbjct: 1047 -------LKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLE 1099
Query: 177 DCLDPDERNDKASDEDLILKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLA 236
D + N K +E LK +L+ E K +E + V + + R+ I L
Sbjct: 1100 ---DTKQTNAKLQNELDTLKENNLKNVEELNKS-----KELLTVENQKMEEFRKEIETLK 1151
Query: 237 SEVNREQKKAASCTEEKEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVS 296
++ ++ ++ EE KL ++L +++ + K+ +ER + Q+ + K+E
Sbjct: 1152 QAAAQKSQQLSALQEENVKLAEEL---GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESK 1208
Query: 297 LLKKSSSE---LEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIR 353
+K + E L+KS+ + +T ++ R ++ +LRG ++ ++ ++
Sbjct: 1209 FIKDADEEKASLQKSISITSALLTEKDAELEKLRNEV-TVLRGE----NASAKSLHSVVQ 1263
Query: 354 EMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKA-ENMLETLQGQLTHLE 412
++S + + V LE Q+ E QL SG ++A E+ ++ L + L+
Sbjct: 1264 TLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQ 1323
Score = 73.2 bits (178), Expect = 8e-13
Identities = 123/568 (21%), Positives = 239/568 (42%), Gaps = 50/568 (8%)
Query: 23 DHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKA 82
++LSEV +E L + + +E + V Q +Q+ +K+ KE L +
Sbjct: 826 ENLSEVSQVKETLEKELQILKEKFAEASEEAVS---VQRSMQETVNKLHQKEEQFNMLSS 882
Query: 83 EMESYKENNARKSSLLTSLRDRVQELEEESAALST------------SKIRTEITAHAAI 130
++E +EN A + +R ++L + L S T++ +
Sbjct: 883 DLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRL 942
Query: 131 KEN--QELKKKVVELNEKLQKCSKENEENKKQVSKN----CRKHEEFLTQL-RDCLDPDE 183
KE +EL+ K+ + NE K E+ + ++ +KHEE +L R D ++
Sbjct: 943 KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEK 1002
Query: 184 RNDKASDEDLILKLRDLRKENEF-VKGQIVI--LEETINVHEMEAKASRETIMRLASEVN 240
+ + + ++ LK R R +E K + ++ L++T+ E + K +RE L E+
Sbjct: 1003 KMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELE 1062
Query: 241 REQKKAASCTEEKEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKK 300
+K+A +K K Q A++ E + +E L +Q + E+ LK+
Sbjct: 1063 ELRKQA-----DKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1117
Query: 301 SSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREE 360
++ + + L S++ +T + FR++I L + + E ++ +
Sbjct: 1118 NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGR 1177
Query: 361 SRDRMVS--QLEAQIS----ELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAE 414
SRD + S +LE + S +L+E +ES F + A + + + LT +AE
Sbjct: 1178 SRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAE 1237
Query: 415 LVSGGVLRDNLNF--EKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLE 472
L LR+ + + K L + Q ++ D++ EL L++ L ++ +
Sbjct: 1238 LEK---LRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKV-KNLELQLKENKRQLSSS 1293
Query: 473 SNAVIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAH 532
S T A +R ++Q + L S + + Q + +++ E + AL D+ +
Sbjct: 1294 SG---NTDTQADEDERAQESQIDFLNSVIVDLQRKNQDL-KMKVEMMSEAALNGNGDDLN 1349
Query: 533 LTIRNLQ----KKVERLQKELNTCRDLH 556
+ Q KK RL ++ C DLH
Sbjct: 1350 NYDSDDQEKQSKKKPRLFCDICDCFDLH 1377
Score = 71.2 bits (173), Expect = 3e-12
Identities = 100/463 (21%), Positives = 188/463 (40%), Gaps = 73/463 (15%)
Query: 207 VKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLLSAVE- 265
++ ++ + + + H +E +A + + + +RE+ + + EE+++ +DL VE
Sbjct: 388 IEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEE 447
Query: 266 ---AKEALEREVKIFQERLLAGQQVWDASKQEVSLL--KKSSSELEKSLKASQDAVTTSQ 320
K LE + K+ R+ + E SLL K + +L++ L+ ++ A + +
Sbjct: 448 ESITKGDLETQTKLEHARI---------KELEQSLLFEKTKADKLQRELEDTRVATVSEK 498
Query: 321 SQYFSFREKIA------ALLRGRL--SMTGSTEDTILEKIREMDSREESRDRMVSQLEAQ 372
S+ + +A A LR RL + D L ++E+ S +E + + + +
Sbjct: 499 SRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQRE 558
Query: 373 ISELVEQLGKESGFHQKALQRAQKAENML----ETLQGQLTHLEAELVSGGVLRDNLNFE 428
I+ L E G HQK ++ A L E+L+ +L H E D +
Sbjct: 559 ITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKE------NSDVIALW 612
Query: 429 KQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQR 488
K K + Q M+ +++ G T + L++ H ++
Sbjct: 613 KSKLETAIASHQQAMEELKVSFSKGLG-------TETAEFAELKTQIEKMRLDYQHEIEN 665
Query: 489 KLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRN-LQKKVERLQK 547
Q + M LR K+ + ++ E++N+ IR+ L K ++
Sbjct: 666 LQNQQDSERAAHAKEMEALRAKLMK----------VIKEKENSLEAIRSKLDKAEDQHLV 715
Query: 548 ELNTCRDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSE 607
E+ + E + K+ + L+ K EQTK I++ ++K EK L +
Sbjct: 716 EMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFT------SQLKATEEKLL-----D 764
Query: 608 LDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQL 650
LD + E K SEMK L++ LE AEK+ K L
Sbjct: 765 LDALRKASSEGK-----------SEMKKLRQQLEAAEKQIKHL 796
Score = 38.5 bits (88), Expect = 0.022
Identities = 44/150 (29%), Positives = 71/150 (47%), Gaps = 24/150 (16%)
Query: 514 LEEEKQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLH----TELKAKLADTNEL 569
L+E++Q L+ ERD + V +++EL RD H EL+AK+ D
Sbjct: 357 LKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKM-DQLRT 415
Query: 570 KIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTT-EHEAKENKERARNMIEV 628
++ ++ K +E LN QLE+ K K E V+ E T + E + E AR
Sbjct: 416 MVEAADREK-VELLN----QLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHAR----- 465
Query: 629 VTSEMKTLKKSL----EEAEKREKQLADFR 654
+K L++SL +A+K +++L D R
Sbjct: 466 ----IKELEQSLLFEKTKADKLQRELEDTR 491
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 100 bits (248), Expect = 6e-21
Identities = 136/640 (21%), Positives = 282/640 (44%), Gaps = 103/640 (16%)
Query: 23 DHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKA 82
+ + E +++L + EL ++ E Q+E++DL+ ++ E+
Sbjct: 660 EKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQL-------SEMHD 712
Query: 83 EMESYKENNAR-KSSLLTSLRDRVQELE------EESAALSTSKIRTEITAHAAIKE--- 132
E++S K + R K +L+ L Q+L+ EE L + R A+KE
Sbjct: 713 ELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVS 772
Query: 133 --NQELKKKVVELNEKLQKCSKENEENKKQVS-----KNCRKHEEFLTQLRDCLDPDERN 185
+QE+ K + + +LQ + EE K V N + ++ T++R L +E
Sbjct: 773 SHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENE 832
Query: 186 D-KASDEDLILKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQK 244
+ E+L ++ L+++ E +KG +ET+ +E E + E ++
Sbjct: 833 KLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARK------- 885
Query: 245 KAASCTEEKEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSE 304
EEKE AV A+ ALE E++ Q L Q KQ LK+ S +
Sbjct: 886 ------EEKE--------AVSARRALENELEAAQGNL---SQTTQEQKQLSEKLKEESEQ 928
Query: 305 LEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDR 364
E+ + + +++ + + I L + + ++ + LE ++D +E R
Sbjct: 929 KEQLRRLKNE----MENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRR 984
Query: 365 MVSQLEAQISELVEQLGK----------ESGFHQKALQRAQKAENMLET----LQGQLTH 410
+++++ Q+ E + K E ++ L+ Q+A++ T L+ L
Sbjct: 985 ELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKD 1044
Query: 411 LEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVR 470
LE EL + L+D ++ + +K ++ +++++ D+ + + EQ+ +
Sbjct: 1045 LEYELEAKSHLKD----DRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQ 1100
Query: 471 LESNAVIENKTIAHNLQ---RKLKTQKERLESKELHMS------------LLRQKIAQLE 515
L N +++ + +L+ L+ Q + L+S+ +H+ + +IA+LE
Sbjct: 1101 LR-NELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELE 1159
Query: 516 EEKQARTALVVERDNAHLTI--RNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKT 573
+ ++ ERD A+L + R L++KV+ L +++ D H L + D L++K
Sbjct: 1160 DRLESE-----ERDRANLQLSNRRLERKVKELVMQVD---DEHLSLTDQ-KDQLSLRLKA 1210
Query: 574 LEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEH 613
++ + +E+ + D+LE K+K +++L + ++D EH
Sbjct: 1211 MK--RQVEEAEEEIDRLESSKKKLQREL---EEQMDMNEH 1245
Score = 82.8 bits (203), Expect = 1e-15
Identities = 127/658 (19%), Positives = 280/658 (42%), Gaps = 82/658 (12%)
Query: 61 SELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKI 120
SE++DL + + EL+ +++ +N +R ++EL +
Sbjct: 607 SEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQH-------- 658
Query: 121 RTEITAHAAIKENQELKKKVVELNEKLQKCSKE---NEENKKQVSKNCRKHEEFLTQLRD 177
+ ++EN L++++ E +L+K +E + ++Q R ++ L+++ D
Sbjct: 659 ------NEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHD 712
Query: 178 CLDPDERND--------------KASDEDLILKLRD----LRKENEFVKGQIVILEETIN 219
LD +R++ K +DL++ + LRK + L+E ++
Sbjct: 713 ELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVS 772
Query: 220 VHEM-----------EAKASRETIMR-------LASEVNREQKKAASCTEEKEKLNQDLL 261
H+ E +A RE++ LAS N ++ A TE + KL Q+
Sbjct: 773 SHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAG-TEMRVKLLQEEN 831
Query: 262 SAVEAK-EALEREVKIFQERL--LAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTT 318
++ + E LER V Q ++ L G + +K+ + + +LE++L ++
Sbjct: 832 EKLQGRSEELERRVAQLQRQIEDLKGDEA--KAKETLKKYEGEIRQLEEALVHARKEEKE 889
Query: 319 SQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQ---ISE 375
+ S + ++ A +G LS T + + EK++E ++E R+ +++E + + +
Sbjct: 890 AVSARRALENELEA-AQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGK 948
Query: 376 LVEQLGKE-----SGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQ 430
+E+L KE L+ + + E + +L ++ +L + +
Sbjct: 949 TIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAM 1008
Query: 431 KYLKFLDQLSQKMKLDQMAAELGFDMR--LDVVLARTEQLVRLESNAVIENKTIAHNLQR 488
K + + ++++ Q A + R L+ L E + +S+ + + ++
Sbjct: 1009 KMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMED 1068
Query: 489 KLKTQKERLESKELHMSLLRQKIAQLEEE-KQARTALVVERDNAHLTIRNLQKKVERLQK 547
K+ + LE + + LL ++I++ E+ +Q R L+ ER A + + +ER K
Sbjct: 1069 KVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQER-AARQDLECDKISLERQNK 1127
Query: 548 ELNTCRDLHTE-----LKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLM 602
+L + R +H E K L E +I LE +E + R L+ + E+K+
Sbjct: 1128 DLKS-RIIHLEGSYRSSKEGLVVQMEARIAELED--RLESEERDRANLQLSNRRLERKVK 1184
Query: 603 SVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREVVSQM 660
+ ++D + K++ ++ + +++ ++ ++ E +K+L RE+ QM
Sbjct: 1185 ELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQ--RELEEQM 1240
Score = 56.6 bits (135), Expect = 8e-08
Identities = 96/455 (21%), Positives = 192/455 (42%), Gaps = 40/455 (8%)
Query: 223 MEAKASRE-TIMRLASEVNREQKKAASCTEEKEKLNQDLLSAVEAKEALER-EVKIFQER 280
+E + S+E T++R S + +K+ T + Q+ +A ++ VK F
Sbjct: 471 LETEGSQESTVIRAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFPSA 530
Query: 281 --------LLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAA 332
LL GQQ E + + + L++ + DA + F EKI
Sbjct: 531 SNTQATPDLLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVF---EKIQT 587
Query: 333 LLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQ 392
L + R + + + E+ E + S+L +++EL QL E Q +
Sbjct: 588 L-KSRAAGSAQGNNQACNSTSEVKDLLEQK----SKLTIEVAELQRQLQLEVKNQQNIKE 642
Query: 393 RAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQ-KMKLDQMAAE 451
++ LE L+ Q H E ++ L+ L + + K L++L Q KM+ +Q E
Sbjct: 643 ERERMRANLEELRSQ--HNE-KVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTE 699
Query: 452 LGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKI 511
+ D++ D + ++L + + E + L + + ++ L +KE LLR++
Sbjct: 700 IR-DLQ-DQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRE 757
Query: 512 AQLEEEKQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKI 571
+L K A V D + + K E+ EL R+ E K + +
Sbjct: 758 RELTALKGALKEEVSSHD------QEMDKLKEQYDAELQALRE-SVEEATKNVEVLASRS 810
Query: 572 KTLEQTKA-----IEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMI 626
T EQ +A ++ L + ++L+ E+ E+++ ++ +++ + K ++ +A+ +
Sbjct: 811 NTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIE----DLKGDEAKAKETL 866
Query: 627 EVVTSEMKTLKKSLEEAEKREKQLADFREVVSQML 661
+ E++ L+++L A K EK+ R + L
Sbjct: 867 KKYEGEIRQLEEALVHARKEEKEAVSARRALENEL 901
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 98.6 bits (244), Expect = 2e-20
Identities = 141/657 (21%), Positives = 276/657 (42%), Gaps = 96/657 (14%)
Query: 27 EVPVTREQLNH---YRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAE 83
E+ RE L+ R++ Q ++E+A L K E + EL+ +K+ ++E S Q+ ++
Sbjct: 681 ELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSK 740
Query: 84 MESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVEL 143
+ + E+ A+ L L V +LEEE +AL + + E A A +E + L++ +E
Sbjct: 741 LSALNESLAQDKLDLNRL---VAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLE- 796
Query: 144 NEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRKE 203
Q+ +++ E +V++ + E L +L LR E
Sbjct: 797 ----QEVARQGLEGSLRVAEQAQ------------------------EALEQQLPTLRHE 828
Query: 204 NEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLLSA 263
++ Q+ L ++ E E + +R R + R A
Sbjct: 829 RSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALER---------------------A 867
Query: 264 VEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQY 323
KEAL +E +L+A ++ +E + L+ LE SL Q + +++
Sbjct: 868 AREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARR 927
Query: 324 FSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKE 383
+ ALL + ++TG + I + ++ M +L E L ++
Sbjct: 928 EQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQ 987
Query: 384 SGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKM 443
H++ LQR Q+ + + LEAE L+ L E+++ L L+ ++K
Sbjct: 988 RAAHEEDLQRLQREK------EAAWRELEAERAQ---LQSQLQREQEELLARLE--AEKE 1036
Query: 444 KLDQMAAELGFDMRLDVVLARTEQ-----LVRLESNAVIEN--------KTIAHNLQRKL 490
+L + A L + ++LA +E+ L E A+ E TI+ ++R+
Sbjct: 1037 ELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQK 1096
Query: 491 KTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQKKVERLQKELN 550
+ + R E ++ L ++ L +++ A + +R LQ++ L K+ +
Sbjct: 1097 RDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQE------VRRLQEQARDLGKQRD 1150
Query: 551 TC----RDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKS 606
+C +L T+L+ + L+ + LE A L +S++ E +++A + S+
Sbjct: 1151 SCLREAEELRTQLRLLEDARDGLRRELLE---AQRKLRESQEGREVQRQEAGELRRSLGE 1207
Query: 607 ELDTTEHEA-KENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREVVSQMLG 662
E EA + + E R+ ++ SE +LK + E+ E++ L + R V + G
Sbjct: 1208 --GAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAG 1262
Score = 90.1 bits (222), Expect = 6e-18
Identities = 133/633 (21%), Positives = 262/633 (41%), Gaps = 62/633 (9%)
Query: 61 SELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKI 120
S L + S + +++ Q+++ E+ ++ LL +LR ++ + E E AL
Sbjct: 519 STLALIHSALHKRQLQVQDMRGRYEASQD-------LLGTLRKQLSDSESERRALEEQLQ 571
Query: 121 RTEITAHAAIKENQELKKKVVELNEKLQKCSKENE------ENKKQVSKNCRKHEEFLTQ 174
R A++ +++ +++V L + S+E + +Q ++ R+ E L
Sbjct: 572 RLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQA 631
Query: 175 LRDCLDPDERNDKASDEDLILKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMR 234
++ L + ED + +R+E E Q+ LE +V E RE + R
Sbjct: 632 AQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSR 691
Query: 235 LASEVNREQKKAASCTEEKEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQE 294
+ + Q + A E K + + L E Q+ L + ++ Q+
Sbjct: 692 ATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQD 751
Query: 295 VSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIRE 354
L + ++LE+ A Q ++ + RE+ L RL + + + +R
Sbjct: 752 KLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQG-LEGSLRV 810
Query: 355 MDSREESRDRMVSQLEAQISELVEQLG----KESGFHQKALQRAQKAENMLETLQGQLTH 410
+ +E+ ++ + L + S+L EQL + SG Q+ Q ++A+ +E L+
Sbjct: 811 AEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAARE 870
Query: 411 LEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAE---LGFDMRLDVVLARTEQ 467
EA L L ++ + L + + +++L++ A E +L + AR EQ
Sbjct: 871 KEALAKEHAGLAVQL-VAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQ 929
Query: 468 LVRLESNAVIENKTIAHNL----QRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTA 523
L ++ +T+ L Q+ + TQ E L L+ QK+ Q E E QA +
Sbjct: 930 LEAEGQALLLAKETLTGELAGLRQQIIATQ----EKASLDKELMAQKLVQAEREAQA--S 983
Query: 524 LVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTK----- 578
L +R ++ LQ++ E +EL R +L+++L E + LE K
Sbjct: 984 LREQRAAHEEDLQRLQREKEAAWRELEAER---AQLQSQLQREQEELLARLEAEKEELSE 1040
Query: 579 AIEDLNKSRDQLEKMKEKAEKKLMSVKS----------------------ELDTTEHEAK 616
I L + RD+ + E +++ +S+K E++ + +A+
Sbjct: 1041 EIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQ 1100
Query: 617 ENKERARNMIEVVTSEMKTLKKSLEEAEKREKQ 649
+E+ R+ + +TSE++ L+ EEA Q
Sbjct: 1101 SRQEQDRSTVNALTSELRDLRAQREEAAAAHAQ 1133
Score = 71.2 bits (173), Expect = 3e-12
Identities = 138/670 (20%), Positives = 271/670 (40%), Gaps = 99/670 (14%)
Query: 32 REQLNHYRNVA---QNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESYK 88
++QL+H R + + AR+E A ++ A+ Q L +++ EV + +A++ +
Sbjct: 1378 KQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLR 1437
Query: 89 ENNARKSSLLTS------------LRDRVQE-----LEEESAALSTSKIRTEITAHAAIK 131
R L + RD E L S + + A
Sbjct: 1438 SALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSP 1497
Query: 132 ENQELKKKVV-----ELNEKLQKCSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERND 186
+ +L + V E ++L+ +E +E + Q S R+ E + +
Sbjct: 1498 ASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQ 1557
Query: 187 KASDEDLILKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKA 246
KA E + R + V+ ++ + EE++ E E +A+ + + L +++
Sbjct: 1558 KAVAESEEAR-RSVDGRLSGVQAELALQEESVRRSERERRATLDQVATL--------ERS 1608
Query: 247 ASCTEEKEKLNQDLLSAVEAKEA-LEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSEL 305
TE + + +Q+ +S ++A E LE + + +E V DAS+ L+ L
Sbjct: 1609 LQATESELRASQEKISKMKANETKLEGDKRRLKE-------VLDASESRTVKLELQRRSL 1661
Query: 306 EKSLKASQDAVTTSQSQYFSFREKIAALLR---------GRLSMTGSTEDTILEKIREMD 356
E L+ S+ ++ ++Q + ++++ +L R G L +T + L K+ E +
Sbjct: 1662 EGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESE 1721
Query: 357 SREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAELV 416
+ R +++ AQ S + ++ QKAL +
Sbjct: 1722 GALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQ----------------- 1764
Query: 417 SGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTE-QLVRLESNA 475
VL++ L+ +Q + Q S + Q D+ L V A + Q +R
Sbjct: 1765 ---VLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQ 1821
Query: 476 VIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQ--ARTALVVERDNAHL 533
E + A N +KL+ ++ L+ + + L++ +AQLE EK+ R+AL +E+D +
Sbjct: 1822 RQEGEAAALNTVQKLQDERRLLQER---LGSLQRALAQLEAEKREVERSALRLEKD--RV 1876
Query: 534 TIRNLQKKVE-----------RLQKELNTCRDLHTELKAKLADTN------ELKIKTLEQ 576
+R KVE RL E T + +LA+ E ++ LEQ
Sbjct: 1877 ALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQ 1936
Query: 577 TKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTL 636
+ + L Q + ++ ++L S +++ + T EA+E R R + + ++ TL
Sbjct: 1937 SHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERT-LEARERAHRQR--VRGLEEQVSTL 1993
Query: 637 KKSLEEAEKR 646
K L++ +R
Sbjct: 1994 KGQLQQELRR 2003
Score = 63.9 bits (154), Expect = 5e-10
Identities = 155/738 (21%), Positives = 300/738 (40%), Gaps = 116/738 (15%)
Query: 33 EQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNA 92
E+L + ++AR L L++ + + LR +EV QE S E
Sbjct: 1157 EELRTQLRLLEDARDGLRRELLEAQ------RKLRESQEGREVQRQEAGELRRSLGEGAK 1210
Query: 93 RKSSLLTS---LRDRVQELEEESAALSTS------KIRTEITAHAAI-KENQELKKKVVE 142
+ +L S LR V++ E E +L + K+ A A+ KE EL+ + E
Sbjct: 1211 EREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQE 1270
Query: 143 LNEKLQKCSKENEENKKQV----SKNCRKHEEFLTQLRDCLDPDERNDKASD-EDLILKL 197
+ + +E +E ++Q+ S+N R E L +L+ L ER +K S E L L+
Sbjct: 1271 VERSRLEARRELQELRRQMKMLDSENTRLGRE-LAELQGRLALGERAEKESRRETLGLRQ 1329
Query: 198 RDLRKEN--EFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQK----------- 244
R L+ E E ++ ++ + + + E E + ++ E +K
Sbjct: 1330 RLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLEL 1389
Query: 245 KAASCTEEKEKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSL---LKKS 301
K + E +L L +A + LE E+ + + A + + + L ++
Sbjct: 1390 KLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRA 1449
Query: 302 SSELEKSLKAS--QDAVTTSQSQYFSFREKIAALLRGRLSMTG-------------STED 346
S + + S +DA + + + + G +
Sbjct: 1450 PSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRG 1509
Query: 347 TILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKA--LQRA-QKAENMLET 403
+ E ++E+ S + RD + +Q A +L E + +A LQ+A ++E +
Sbjct: 1510 ALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRS 1569
Query: 404 LQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLS--------------------QKM 443
+ G+L+ ++AEL + +++ +++ LDQ++ KM
Sbjct: 1570 VDGRLSGVQAEL---ALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKM 1626
Query: 444 KLDQMAAELGFDMRLDVVLARTE-QLVRLESNAVIENKTIAHNLQRK---LKTQKERLES 499
K ++ E G RL VL +E + V+LE ++ +++ LQR L ++ + ++
Sbjct: 1627 KANETKLE-GDKRRLKEVLDASESRTVKLE----LQRRSLEGELQRSRLGLSDREAQAQA 1681
Query: 500 KELHMSLLRQKIAQLEEEKQARTALVVERDNAHLT------------IRNLQKKVERLQK 547
+ + L++++A E K L VER N L +R L + + +
Sbjct: 1682 LQDRVDSLQRQVAD-SEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSA 1740
Query: 548 ELNTCRDLHTEL-KAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEK--------AE 598
LN+ RD + L KA A ++ ++ A + L+++R Q + E+ A+
Sbjct: 1741 SLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVAD 1800
Query: 599 KKLMSVKSE-----LDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQL-AD 652
+L V++E L + +E + A N ++ + E + L++ L ++ QL A+
Sbjct: 1801 LELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAE 1860
Query: 653 FREVVSQMLGLNVTSLAL 670
REV L L +AL
Sbjct: 1861 KREVERSALRLEKDRVAL 1878
Score = 63.5 bits (153), Expect = 6e-10
Identities = 134/680 (19%), Positives = 265/680 (38%), Gaps = 103/680 (15%)
Query: 63 LQDLRSKMLSKEVSCQELK-------AEMESYKENNARKSSLLTSLRDRVQELEEESAAL 115
+Q L+ K+L + C EL+ E+E + + S L S R++E ++ SA+L
Sbjct: 173 VQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASL 232
Query: 116 STSKIRTEITAHAAIKENQELKKKVVELNEKLQKCSKENEEN-----KKQVSKNC---RK 167
+ A NQ L + + ++ +C KE E +++ S N +
Sbjct: 233 AQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNE 292
Query: 168 HEEFLTQLRDCLDPDERNDKA---SDEDLI-----------------------LKLRDLR 201
H L R + + ++ DL+ L+L + R
Sbjct: 293 HSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESR 352
Query: 202 KENEFVKGQI------------VILEETINVHEMEAKASRETIMRLASEVNREQKKAASC 249
E K + V+ E+ + +M++ + + +E+ K+
Sbjct: 353 AEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQ 412
Query: 250 TEEKEKLNQDLLSAVEAKEA--LEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSEL-- 305
EK+++N+DL +EA E+ L+ + + E QQ Q V +S +L
Sbjct: 413 NLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSG 472
Query: 306 -EKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTG-----STEDTI------LEK-- 351
E++ AS ++ Q + ++ RGR G S T+ L K
Sbjct: 473 SERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQ 532
Query: 352 --IREMDSREESRDRMVSQLEAQISE-------LVEQL----GKESG---FHQKALQRAQ 395
+++M R E+ ++ L Q+S+ L EQL K G H+ A + Q
Sbjct: 533 LQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQ 592
Query: 396 KAENMLETLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQL-SQKMKLDQM---AAE 451
+ + E L + ++L L + L E++K ++L Q+ +L++ A +
Sbjct: 593 RLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQ 652
Query: 452 LGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKI 511
G +R ++ + QL +LE + L ++L +E L L +L+ +
Sbjct: 653 DGARVRRELERSH-RQLEQLEGKRSV--------LAKELVEVREALSRATLQRDMLQAEK 703
Query: 512 AQLEEEKQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKI 571
A++ E A T R L++ L+ + LQ L+ L+ L D N L
Sbjct: 704 AEVAE---ALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVA 760
Query: 572 KTLEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTS 631
+ E+ A++ + +Q + + +++L ++ E + + + A E +
Sbjct: 761 QLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQ 820
Query: 632 EMKTLKKSLEEAEKREKQLA 651
++ TL+ + +++ QL+
Sbjct: 821 QLPTLRHERSQLQEQLAQLS 840
Score = 56.6 bits (135), Expect = 8e-08
Identities = 160/727 (22%), Positives = 276/727 (37%), Gaps = 128/727 (17%)
Query: 15 SPAPEETYDHLSEVPVTREQLNHYRNVAQNARSE--LAATLVKFECA---QSELQDLRSK 69
S E + L+ + +E+L+ Q R E L A K + +SE L K
Sbjct: 1018 SQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEK 1077
Query: 70 MLSKEVSCQELKAEMESYK--------ENNARKSSLLTSLRDRVQELEEESAALSTSKIR 121
++ S + EME K ++ + ++L + LRD + EE +AA + R
Sbjct: 1078 LMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRR 1137
Query: 122 TEITAH-------AAIKENQELK--------------KKVVELNEKLQKCSKENEENKKQ 160
+ A + ++E +EL+ ++++E KL++ S+E E ++Q
Sbjct: 1138 LQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRE-SQEGREVQRQ 1196
Query: 161 VSKNCRKHEEFLTQLRDCLDPDERN-----DKASDEDLILKLRDLRKENEFVKGQIVILE 215
+ R+ + R+ L KA E + LKL + KE + + +LE
Sbjct: 1197 EAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQK-----LALLE 1251
Query: 216 ET----------INVHEMEAKASRETIMRLASEVNREQKKAAS----CTEEKEKLNQDLL 261
E + E + SR R E+ R+ K S E +L L
Sbjct: 1252 EARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLA 1311
Query: 262 SAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQS 321
A++ RE ++RLL G+ + +QE+ + ++ E Q
Sbjct: 1312 LGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQE---------------QE 1356
Query: 322 QYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLG 381
F RE+ L G L TE L+ R ++ + E+ A+ +EL +L
Sbjct: 1357 GEFRTRER---RLLGSLEEARGTEKQQLDHARGLELKLEA-------ARAEAAELGLRLS 1406
Query: 382 KESGFHQKALQRAQKAENMLETLQGQLTHLEAELVSGGV---LRDNLNFEKQKYLKFLDQ 438
G RAQ E L ++ Q EA+L GG+ LR L +
Sbjct: 1407 AAEG-------RAQGLEAELARVEVQRRAAEAQL--GGLRSALRRGLGLGRAP-SPAPRP 1456
Query: 439 LSQKMKLDQMAAELGFDMRLDVVL-------------ARTEQLVRLESNAVIENKTIAHN 485
+ D A G + L A + L+ AV +
Sbjct: 1457 VPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAV--RGALREF 1514
Query: 486 LQRKLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVVERDNAHLTIRNLQKKVERL 545
LQ Q+ER E + S L +++A++E ERD+A R LQK V
Sbjct: 1515 LQELRSAQRERDELR-TQTSALNRQLAEME----------AERDSATSRARQLQKAVAES 1563
Query: 546 QKELNTCRDLHTELKAKLADTNELKIKTLEQTKAIED----LNKSRDQLEKMKEKAEKKL 601
++ + + ++A+LA E ++ + +A D L +S E +++K+
Sbjct: 1564 EEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKI 1623
Query: 602 MSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQLADFREVVSQML 661
+K+ E + + KE + E T +++ ++SLE +R + RE +Q L
Sbjct: 1624 SKMKANETKLEGDKRRLKE-VLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQAL 1682
Query: 662 GLNVTSL 668
V SL
Sbjct: 1683 QDRVDSL 1689
Score = 50.4 bits (119), Expect = 6e-06
Identities = 112/618 (18%), Positives = 253/618 (40%), Gaps = 84/618 (13%)
Query: 61 SELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKI 120
+E+ L S ++ QEL + ++ A + L + V E E++ L ++
Sbjct: 71 TEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKY-NAVSERLEQALRLEPGEL 129
Query: 121 RTEITAHAAIKENQELKKKVVELNEKLQKCSKENEENKK--------------QVSKNCR 166
T+ ++++ EL++++ E ++ + +E ++ Q K C
Sbjct: 130 ETQ-EPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCS 188
Query: 167 KHEEFLTQLRDCLDPDERNDKASDEDL---ILKLRDLRKENEFVKGQIVILEETINVHEM 223
+ E+ L + L+ D +DL +++L + ++ + + +L E ++
Sbjct: 189 ELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGS 248
Query: 224 EAKASRETIMRLASEVNREQK----KAASCTEEKEKLNQDLLSAVEAKEALEREVKIFQE 279
+A E I ++ ++ R +K + A+ E+E N + L R+V F+
Sbjct: 249 ANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFR- 307
Query: 280 RLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLS 339
RL++ +++ L + EL ++ +A Q+A + + A L +
Sbjct: 308 RLVSEVKMFTERD-----LLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQAL 362
Query: 340 MTGSTEDTILEKIREMDSREESRDRMVSQLE-AQISELVEQLGKESGFHQKALQRAQKAE 398
+ E+ + +K+ + ++ ++ +M S L+ A +S V +LG A++R +K
Sbjct: 363 LQAQLEEQLRDKV--LREKDLAQQQMQSDLDKADLSARVTELGL-------AVKRLEKQN 413
Query: 399 NMLETLQGQLTH-LEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMR 457
+ + LT LEA ++L ++Q L+ D + L +A + D
Sbjct: 414 LEKDQVNKDLTEKLEA--------LESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSE 465
Query: 458 LDVVLARTEQLVRLESNAVIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEE 517
V L+ +E+ + ++ L + R S S R +
Sbjct: 466 SGVQLSGSERTADASNGSL-------RGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDS 518
Query: 518 KQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQT 577
+ AL+ H + Q +V+ ++ +DL L+ +L+D+ +
Sbjct: 519 --STLALI------HSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSE-------SER 563
Query: 578 KAIEDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLK 637
+A+E +QL+++++K + + + +A+ +R R+ E+++ E L
Sbjct: 564 RALE------EQLQRLRDKTDGAMQA--------HEDAQREVQRLRSANELLSREKSNLA 609
Query: 638 KSLEEAEKREKQLADFRE 655
SL+ A+++ ++L RE
Sbjct: 610 HSLQVAQQQAEELRQERE 627
Score = 49.7 bits (117), Expect = 1e-05
Identities = 47/239 (19%), Positives = 104/239 (43%), Gaps = 19/239 (7%)
Query: 30 VTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKE 89
V +E+L+ R AR + ++ + + + E+ DL + + E Q+L+ + +E
Sbjct: 1765 VLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQE 1824
Query: 90 NNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELKKKVVELNEKLQK 149
A + + L+D + L+E +L + + E + L+K V L L K
Sbjct: 1825 GEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDK 1884
Query: 150 CSKENEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLILKLRDLRKENEFVKG 209
+E R HE+ + L ++ + L+L + +++ + ++
Sbjct: 1885 VERE----------KLRSHEDTVR-----LSAEKGRLDRTLTGAELELAEAQRQIQQLEA 1929
Query: 210 QIVILEETINVHEMEAKASRETIMRLASEVNR---EQKKAASCTEEKEKLNQDLLSAVE 265
Q+V+LE++ + ++E A ++ + L EV R Q + E +E+ ++ + +E
Sbjct: 1930 QVVVLEQSHSPAQLEVDAQQQQ-LELQQEVERLRSAQAQTERTLEARERAHRQRVRGLE 1987
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 98.6 bits (244), Expect = 2e-20
Identities = 142/679 (20%), Positives = 288/679 (42%), Gaps = 105/679 (15%)
Query: 20 ETYDHLSEVPVTREQLNHYRNVA--QNARSELAATLVKFECAQSELQDLRSKMLSKEVSC 77
E D LS+ + L + A Q+ S L A + ELQD K+ +K
Sbjct: 324 ENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQD---KLQAKSPKE 380
Query: 78 QELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELK 137
E +SY S T L + + E S SK + H+ K +
Sbjct: 381 AEADLSFDSYH-------STQTDLGPSLGKPGETSPP--DSKSSPSVLIHSLGKSTTDND 431
Query: 138 KKVVELNEKLQKCSKE---NEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLI 194
++ +L E LQ K +E +KQ+ + L CL+ E ++ +SD L
Sbjct: 432 VRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELV----CLNNTEISENSSD--LS 485
Query: 195 LKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEK- 253
KL++ + + E +++ +++ + + + + S N TEE+
Sbjct: 486 QKLKETQSKYEEAMKEVLSVQKQMKLGLVSPE----------SMDNYSHFHELRVTEEEI 535
Query: 254 EKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQ 313
L QDL +A+E E + +V+ +E+L+ +++ +++K E E+ +K+S
Sbjct: 536 NVLKQDLQNALEESERNKEKVRELEEKLV--------EREKGTVIKPPVEEYEE-MKSSY 586
Query: 314 DAVTTSQSQYFSFR-EKIAALLRGRLSMTGSTEDTILEKIR-EMDSREESRDRMVSQLEA 371
+V + ++ +F EK + + + + + ++ E + +E+ +RM+ +L
Sbjct: 587 CSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNK 646
Query: 372 QISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTH---LEAELVSGGVLRDNLNFE 428
Q+SEL QL KE+ + ++ + E++ + H ++ VS D L+
Sbjct: 647 QVSEL-SQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEM 705
Query: 429 KQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQR 488
K +Y K L++L+Q +L D + + ++ TE L + +T A ++
Sbjct: 706 KSQYSKVLNELTQLKQL--------VDAQKENSVSITEHL-----QVITTLRTAAKEMEE 752
Query: 489 KLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVV---------------------- 526
K+ KE L SKE+ ++ L + QL EEK A T +V
Sbjct: 753 KISNLKEHLASKEVEVAKLEK---QLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASK 809
Query: 527 ------ERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAI 580
E++ H + ++ +V ++++E ++ T LK+K + NEL K + + +
Sbjct: 810 LKESVKEKEKVHSEVVQIRSEVSQVKREKE---NIQTLLKSKEQEVNELLQKFQQAQEEL 866
Query: 581 EDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHE---------AKENKERARNMIEVVTS 631
++ + + K++E +KK+ + E+ + + + +R +E +
Sbjct: 867 AEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQ 926
Query: 632 EMKTLKKSLEEAEKREKQL 650
++K L+ L E +K+ +++
Sbjct: 927 QVKQLQNQLAECKKQHQEV 945
Score = 75.9 bits (185), Expect = 1e-13
Identities = 101/459 (22%), Positives = 195/459 (42%), Gaps = 72/459 (15%)
Query: 3 LDCTSHIALGAASPAPEETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSE 62
L + LG SP + Y H E+ VT E++N + QNA L + E + +
Sbjct: 503 LSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNA-------LEESERNKEK 555
Query: 63 LQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLR-------DRVQELEEESAAL 115
+++L K++ +E +K +E Y+E + S++ ++ ++ QE +EE L
Sbjct: 556 VRELEEKLVEREKG-TVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKL 614
Query: 116 STSKIRTEITAHAA-----IKEN-----QELKKKVVELNEKLQKCSKENEENKKQVSK-- 163
+ +++++T A+ +KE EL K+V EL++ ++ E E+ +K+ S
Sbjct: 615 KDT-LKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLED 673
Query: 164 ------NCRKHEEF--LTQLRDCLDPDERNDKASDEDLIL-------KLRDLRKEN--EF 206
+ +HE+ LT + D ++ S +L +L D +KEN
Sbjct: 674 VTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSI 733
Query: 207 VKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLL---SA 263
+ VI EME K S LAS+ K EEK + ++ S
Sbjct: 734 TEHLQVITTLRTAAKEMEEKIS-NLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 792
Query: 264 VEAKEALEREVKIFQERLLAGQQVWD-------ASKQEVSLLKKSSSELEKSLKASQDAV 316
+ + +LE EV + +L + + + EVS +K+ ++ LK+ + V
Sbjct: 793 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV 852
Query: 317 TTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISEL 376
++ +E++A + R S + EE +D+ ++++ ++++L
Sbjct: 853 NELLQKFQQAQEELAEMKRYAESSS---------------KLEEDKDKKINEMSKEVTKL 897
Query: 377 VEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAEL 415
E L S + +++ LE LQ Q+ L+ +L
Sbjct: 898 KEALNSLSQL-SYSTSSSKRQSQQLEALQQQVKQLQNQL 935
Score = 67.0 bits (162), Expect = 6e-11
Identities = 125/575 (21%), Positives = 247/575 (42%), Gaps = 81/575 (14%)
Query: 54 VKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESA 113
V+ + Q LQDL+ ++ S E ++L+ E++S + L L + E+ E S+
Sbjct: 432 VRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAE-------LVCLNNT--EISENSS 482
Query: 114 ALSTSKIRTEITAHAAIKENQELKKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLT 173
LS T+ A+KE ++K++ KL S E+ +N + EE
Sbjct: 483 DLSQKLKETQSKYEEAMKEVLSVQKQM-----KLGLVSPESMDNYSHFHELRVTEEEINV 537
Query: 174 ---QLRDCLDPDERNDKASDEDLILKLRDLRKEN-EFVKGQIVILEETINVHEMEAKASR 229
L++ L+ ERN + K+R+L ++ E KG ++ + + +E E K+S
Sbjct: 538 LKQDLQNALEESERNKE--------KVRELEEKLVEREKGTVI--KPPVEEYE-EMKSSY 586
Query: 230 ETIMRLASEVNREQ----KKAASCTEEKEKLNQDLLSAVEAKEALERE-VKIFQERLL-- 282
+++ +N+E+ +K EE KL L S + + + E E +K R++
Sbjct: 587 CSVIE---NMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDE 643
Query: 283 AGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTG 342
+QV + S+ L K++ +ELE K T++ + + EK+ + +T
Sbjct: 644 LNKQVSELSQ----LYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKL-------MQLTN 692
Query: 343 STEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLE 402
+ + + EM S+ ++QL+ + E + Q A+ M E
Sbjct: 693 VSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE 752
Query: 403 TLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVL 462
+ HL ++ V L L EK D + + +++ + L + + V+
Sbjct: 753 KISNLKEHLASKEVEVAKLEKQLLEEKAA---MTDAMVPRSSYEKLQSSL--ESEVSVLA 807
Query: 463 ARTEQLVRLESNA---VIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEE-- 517
++ ++ V+ + V++ ++ ++R+ + + L+SKE ++ L QK Q +EE
Sbjct: 808 SKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELA 867
Query: 518 ---KQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKT- 573
+ A ++ +E D KK+ + KE+ T+LK L ++L T
Sbjct: 868 EMKRYAESSSKLEEDK--------DKKINEMSKEV-------TKLKEALNSLSQLSYSTS 912
Query: 574 --LEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKS 606
Q++ +E L + QL+ + +K+ V S
Sbjct: 913 SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVIS 947
Score = 38.9 bits (89), Expect = 0.017
Identities = 35/153 (22%), Positives = 77/153 (50%), Gaps = 13/153 (8%)
Query: 535 IRNLQKKVERLQKELNTC----RDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQL 590
I+ LQ+ ++ LQK L + + L EL+++ A+ + + E ++ DL++ +
Sbjct: 434 IQQLQEILQDLQKRLESSEAERKQLQVELQSRRAEL--VCLNNTEISENSSDLSQKLKET 491
Query: 591 EKMKEKAEKKLMSVKSE--LDTTEHEAKENKERARNMIEVVTSEMKTLKK----SLEEAE 644
+ E+A K+++SV+ + L E+ +N + V E+ LK+ +LEE+E
Sbjct: 492 QSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHEL-RVTEEEINVLKQDLQNALEESE 550
Query: 645 KREKQLADFREVVSQMLGLNVTSLALPDYEIIK 677
+ ++++ + E + + V + +YE +K
Sbjct: 551 RNKEKVRELEEKLVEREKGTVIKPPVEEYEEMK 583
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 98.6 bits (244), Expect = 2e-20
Identities = 142/679 (20%), Positives = 288/679 (42%), Gaps = 105/679 (15%)
Query: 20 ETYDHLSEVPVTREQLNHYRNVA--QNARSELAATLVKFECAQSELQDLRSKMLSKEVSC 77
E D LS+ + L + A Q+ S L A + ELQD K+ +K
Sbjct: 313 ENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQD---KLQAKSPKE 369
Query: 78 QELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELK 137
E +SY S T L + + E S SK + H+ K +
Sbjct: 370 AEADLSFDSYH-------STQTDLGPSLGKPGETSPP--DSKSSPSVLIHSLGKSTTDND 420
Query: 138 KKVVELNEKLQKCSKE---NEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLI 194
++ +L E LQ K +E +KQ+ + L CL+ E ++ +SD L
Sbjct: 421 VRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELV----CLNNTEISENSSD--LS 474
Query: 195 LKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEK- 253
KL++ + + E +++ +++ + + + + S N TEE+
Sbjct: 475 QKLKETQSKYEEAMKEVLSVQKQMKLGLVSPE----------SMDNYSHFHELRVTEEEI 524
Query: 254 EKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQ 313
L QDL +A+E E + +V+ +E+L+ +++ +++K E E+ +K+S
Sbjct: 525 NVLKQDLQNALEESERNKEKVRELEEKLV--------EREKGTVIKPPVEEYEE-MKSSY 575
Query: 314 DAVTTSQSQYFSFR-EKIAALLRGRLSMTGSTEDTILEKIR-EMDSREESRDRMVSQLEA 371
+V + ++ +F EK + + + + + ++ E + +E+ +RM+ +L
Sbjct: 576 CSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNK 635
Query: 372 QISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTH---LEAELVSGGVLRDNLNFE 428
Q+SEL QL KE+ + ++ + E++ + H ++ VS D L+
Sbjct: 636 QVSEL-SQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEM 694
Query: 429 KQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQR 488
K +Y K L++L+Q +L D + + ++ TE L + +T A ++
Sbjct: 695 KSQYSKVLNELTQLKQL--------VDAQKENSVSITEHL-----QVITTLRTAAKEMEE 741
Query: 489 KLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVV---------------------- 526
K+ KE L SKE+ ++ L + QL EEK A T +V
Sbjct: 742 KISNLKEHLASKEVEVAKLEK---QLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASK 798
Query: 527 ------ERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAI 580
E++ H + ++ +V ++++E ++ T LK+K + NEL K + + +
Sbjct: 799 LKESVKEKEKVHSEVVQIRSEVSQVKREKE---NIQTLLKSKEQEVNELLQKFQQAQEEL 855
Query: 581 EDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHE---------AKENKERARNMIEVVTS 631
++ + + K++E +KK+ + E+ + + + +R +E +
Sbjct: 856 AEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQ 915
Query: 632 EMKTLKKSLEEAEKREKQL 650
++K L+ L E +K+ +++
Sbjct: 916 QVKQLQNQLAECKKQHQEV 934
Score = 75.9 bits (185), Expect = 1e-13
Identities = 101/459 (22%), Positives = 195/459 (42%), Gaps = 72/459 (15%)
Query: 3 LDCTSHIALGAASPAPEETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSE 62
L + LG SP + Y H E+ VT E++N + QNA L + E + +
Sbjct: 492 LSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNA-------LEESERNKEK 544
Query: 63 LQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLR-------DRVQELEEESAAL 115
+++L K++ +E +K +E Y+E + S++ ++ ++ QE +EE L
Sbjct: 545 VRELEEKLVEREKG-TVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKL 603
Query: 116 STSKIRTEITAHAA-----IKEN-----QELKKKVVELNEKLQKCSKENEENKKQVSK-- 163
+ +++++T A+ +KE EL K+V EL++ ++ E E+ +K+ S
Sbjct: 604 KDT-LKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLED 662
Query: 164 ------NCRKHEEF--LTQLRDCLDPDERNDKASDEDLIL-------KLRDLRKEN--EF 206
+ +HE+ LT + D ++ S +L +L D +KEN
Sbjct: 663 VTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSI 722
Query: 207 VKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLL---SA 263
+ VI EME K S LAS+ K EEK + ++ S
Sbjct: 723 TEHLQVITTLRTAAKEMEEKIS-NLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 781
Query: 264 VEAKEALEREVKIFQERLLAGQQVWD-------ASKQEVSLLKKSSSELEKSLKASQDAV 316
+ + +LE EV + +L + + + EVS +K+ ++ LK+ + V
Sbjct: 782 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV 841
Query: 317 TTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISEL 376
++ +E++A + R S + EE +D+ ++++ ++++L
Sbjct: 842 NELLQKFQQAQEELAEMKRYAESSS---------------KLEEDKDKKINEMSKEVTKL 886
Query: 377 VEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAEL 415
E L S + +++ LE LQ Q+ L+ +L
Sbjct: 887 KEALNSLSQL-SYSTSSSKRQSQQLEALQQQVKQLQNQL 924
Score = 67.0 bits (162), Expect = 6e-11
Identities = 125/575 (21%), Positives = 247/575 (42%), Gaps = 81/575 (14%)
Query: 54 VKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESA 113
V+ + Q LQDL+ ++ S E ++L+ E++S + L L + E+ E S+
Sbjct: 421 VRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAE-------LVCLNNT--EISENSS 471
Query: 114 ALSTSKIRTEITAHAAIKENQELKKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLT 173
LS T+ A+KE ++K++ KL S E+ +N + EE
Sbjct: 472 DLSQKLKETQSKYEEAMKEVLSVQKQM-----KLGLVSPESMDNYSHFHELRVTEEEINV 526
Query: 174 ---QLRDCLDPDERNDKASDEDLILKLRDLRKEN-EFVKGQIVILEETINVHEMEAKASR 229
L++ L+ ERN + K+R+L ++ E KG ++ + + +E E K+S
Sbjct: 527 LKQDLQNALEESERNKE--------KVRELEEKLVEREKGTVI--KPPVEEYE-EMKSSY 575
Query: 230 ETIMRLASEVNREQ----KKAASCTEEKEKLNQDLLSAVEAKEALERE-VKIFQERLL-- 282
+++ +N+E+ +K EE KL L S + + + E E +K R++
Sbjct: 576 CSVIE---NMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDE 632
Query: 283 AGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTG 342
+QV + S+ L K++ +ELE K T++ + + EK+ + +T
Sbjct: 633 LNKQVSELSQ----LYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKL-------MQLTN 681
Query: 343 STEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLE 402
+ + + EM S+ ++QL+ + E + Q A+ M E
Sbjct: 682 VSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE 741
Query: 403 TLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVL 462
+ HL ++ V L L EK D + + +++ + L + + V+
Sbjct: 742 KISNLKEHLASKEVEVAKLEKQLLEEKAA---MTDAMVPRSSYEKLQSSL--ESEVSVLA 796
Query: 463 ARTEQLVRLESNA---VIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEE-- 517
++ ++ V+ + V++ ++ ++R+ + + L+SKE ++ L QK Q +EE
Sbjct: 797 SKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELA 856
Query: 518 ---KQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKT- 573
+ A ++ +E D KK+ + KE+ T+LK L ++L T
Sbjct: 857 EMKRYAESSSKLEEDK--------DKKINEMSKEV-------TKLKEALNSLSQLSYSTS 901
Query: 574 --LEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKS 606
Q++ +E L + QL+ + +K+ V S
Sbjct: 902 SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVIS 936
Score = 38.9 bits (89), Expect = 0.017
Identities = 35/153 (22%), Positives = 77/153 (50%), Gaps = 13/153 (8%)
Query: 535 IRNLQKKVERLQKELNTC----RDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQL 590
I+ LQ+ ++ LQK L + + L EL+++ A+ + + E ++ DL++ +
Sbjct: 423 IQQLQEILQDLQKRLESSEAERKQLQVELQSRRAEL--VCLNNTEISENSSDLSQKLKET 480
Query: 591 EKMKEKAEKKLMSVKSE--LDTTEHEAKENKERARNMIEVVTSEMKTLKK----SLEEAE 644
+ E+A K+++SV+ + L E+ +N + V E+ LK+ +LEE+E
Sbjct: 481 QSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHEL-RVTEEEINVLKQDLQNALEESE 539
Query: 645 KREKQLADFREVVSQMLGLNVTSLALPDYEIIK 677
+ ++++ + E + + V + +YE +K
Sbjct: 540 RNKEKVRELEEKLVEREKGTVIKPPVEEYEEMK 572
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 98.6 bits (244), Expect = 2e-20
Identities = 142/679 (20%), Positives = 288/679 (42%), Gaps = 105/679 (15%)
Query: 20 ETYDHLSEVPVTREQLNHYRNVA--QNARSELAATLVKFECAQSELQDLRSKMLSKEVSC 77
E D LS+ + L + A Q+ S L A + ELQD K+ +K
Sbjct: 292 ENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQD---KLQAKSPKE 348
Query: 78 QELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELK 137
E +SY S T L + + E S SK + H+ K +
Sbjct: 349 AEADLSFDSYH-------STQTDLGPSLGKPGETSPP--DSKSSPSVLIHSLGKSTTDND 399
Query: 138 KKVVELNEKLQKCSKE---NEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLI 194
++ +L E LQ K +E +KQ+ + L CL+ E ++ +SD L
Sbjct: 400 VRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELV----CLNNTEISENSSD--LS 453
Query: 195 LKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEK- 253
KL++ + + E +++ +++ + + + + S N TEE+
Sbjct: 454 QKLKETQSKYEEAMKEVLSVQKQMKLGLVSPE----------SMDNYSHFHELRVTEEEI 503
Query: 254 EKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQ 313
L QDL +A+E E + +V+ +E+L+ +++ +++K E E+ +K+S
Sbjct: 504 NVLKQDLQNALEESERNKEKVRELEEKLV--------EREKGTVIKPPVEEYEE-MKSSY 554
Query: 314 DAVTTSQSQYFSFR-EKIAALLRGRLSMTGSTEDTILEKIR-EMDSREESRDRMVSQLEA 371
+V + ++ +F EK + + + + + ++ E + +E+ +RM+ +L
Sbjct: 555 CSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNK 614
Query: 372 QISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTH---LEAELVSGGVLRDNLNFE 428
Q+SEL QL KE+ + ++ + E++ + H ++ VS D L+
Sbjct: 615 QVSEL-SQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEM 673
Query: 429 KQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQR 488
K +Y K L++L+Q +L D + + ++ TE L + +T A ++
Sbjct: 674 KSQYSKVLNELTQLKQL--------VDAQKENSVSITEHL-----QVITTLRTAAKEMEE 720
Query: 489 KLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVV---------------------- 526
K+ KE L SKE+ ++ L + QL EEK A T +V
Sbjct: 721 KISNLKEHLASKEVEVAKLEK---QLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASK 777
Query: 527 ------ERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAI 580
E++ H + ++ +V ++++E ++ T LK+K + NEL K + + +
Sbjct: 778 LKESVKEKEKVHSEVVQIRSEVSQVKREKE---NIQTLLKSKEQEVNELLQKFQQAQEEL 834
Query: 581 EDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHE---------AKENKERARNMIEVVTS 631
++ + + K++E +KK+ + E+ + + + +R +E +
Sbjct: 835 AEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQ 894
Query: 632 EMKTLKKSLEEAEKREKQL 650
++K L+ L E +K+ +++
Sbjct: 895 QVKQLQNQLAECKKQHQEV 913
Score = 75.9 bits (185), Expect = 1e-13
Identities = 101/459 (22%), Positives = 195/459 (42%), Gaps = 72/459 (15%)
Query: 3 LDCTSHIALGAASPAPEETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSE 62
L + LG SP + Y H E+ VT E++N + QNA L + E + +
Sbjct: 471 LSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNA-------LEESERNKEK 523
Query: 63 LQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLR-------DRVQELEEESAAL 115
+++L K++ +E +K +E Y+E + S++ ++ ++ QE +EE L
Sbjct: 524 VRELEEKLVEREKG-TVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKL 582
Query: 116 STSKIRTEITAHAA-----IKEN-----QELKKKVVELNEKLQKCSKENEENKKQVSK-- 163
+ +++++T A+ +KE EL K+V EL++ ++ E E+ +K+ S
Sbjct: 583 KDT-LKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLED 641
Query: 164 ------NCRKHEEF--LTQLRDCLDPDERNDKASDEDLIL-------KLRDLRKEN--EF 206
+ +HE+ LT + D ++ S +L +L D +KEN
Sbjct: 642 VTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSI 701
Query: 207 VKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLL---SA 263
+ VI EME K S LAS+ K EEK + ++ S
Sbjct: 702 TEHLQVITTLRTAAKEMEEKIS-NLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 760
Query: 264 VEAKEALEREVKIFQERLLAGQQVWD-------ASKQEVSLLKKSSSELEKSLKASQDAV 316
+ + +LE EV + +L + + + EVS +K+ ++ LK+ + V
Sbjct: 761 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV 820
Query: 317 TTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISEL 376
++ +E++A + R S + EE +D+ ++++ ++++L
Sbjct: 821 NELLQKFQQAQEELAEMKRYAESSS---------------KLEEDKDKKINEMSKEVTKL 865
Query: 377 VEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAEL 415
E L S + +++ LE LQ Q+ L+ +L
Sbjct: 866 KEALNSLSQL-SYSTSSSKRQSQQLEALQQQVKQLQNQL 903
Score = 67.0 bits (162), Expect = 6e-11
Identities = 125/575 (21%), Positives = 247/575 (42%), Gaps = 81/575 (14%)
Query: 54 VKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESA 113
V+ + Q LQDL+ ++ S E ++L+ E++S + L L + E+ E S+
Sbjct: 400 VRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAE-------LVCLNNT--EISENSS 450
Query: 114 ALSTSKIRTEITAHAAIKENQELKKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLT 173
LS T+ A+KE ++K++ KL S E+ +N + EE
Sbjct: 451 DLSQKLKETQSKYEEAMKEVLSVQKQM-----KLGLVSPESMDNYSHFHELRVTEEEINV 505
Query: 174 ---QLRDCLDPDERNDKASDEDLILKLRDLRKEN-EFVKGQIVILEETINVHEMEAKASR 229
L++ L+ ERN + K+R+L ++ E KG ++ + + +E E K+S
Sbjct: 506 LKQDLQNALEESERNKE--------KVRELEEKLVEREKGTVI--KPPVEEYE-EMKSSY 554
Query: 230 ETIMRLASEVNREQ----KKAASCTEEKEKLNQDLLSAVEAKEALERE-VKIFQERLL-- 282
+++ +N+E+ +K EE KL L S + + + E E +K R++
Sbjct: 555 CSVIE---NMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDE 611
Query: 283 AGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTG 342
+QV + S+ L K++ +ELE K T++ + + EK+ + +T
Sbjct: 612 LNKQVSELSQ----LYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKL-------MQLTN 660
Query: 343 STEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLE 402
+ + + EM S+ ++QL+ + E + Q A+ M E
Sbjct: 661 VSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE 720
Query: 403 TLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVL 462
+ HL ++ V L L EK D + + +++ + L + + V+
Sbjct: 721 KISNLKEHLASKEVEVAKLEKQLLEEKAA---MTDAMVPRSSYEKLQSSL--ESEVSVLA 775
Query: 463 ARTEQLVRLESNA---VIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEE-- 517
++ ++ V+ + V++ ++ ++R+ + + L+SKE ++ L QK Q +EE
Sbjct: 776 SKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELA 835
Query: 518 ---KQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKT- 573
+ A ++ +E D KK+ + KE+ T+LK L ++L T
Sbjct: 836 EMKRYAESSSKLEEDK--------DKKINEMSKEV-------TKLKEALNSLSQLSYSTS 880
Query: 574 --LEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKS 606
Q++ +E L + QL+ + +K+ V S
Sbjct: 881 SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVIS 915
Score = 38.9 bits (89), Expect = 0.017
Identities = 35/153 (22%), Positives = 77/153 (50%), Gaps = 13/153 (8%)
Query: 535 IRNLQKKVERLQKELNTC----RDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQL 590
I+ LQ+ ++ LQK L + + L EL+++ A+ + + E ++ DL++ +
Sbjct: 402 IQQLQEILQDLQKRLESSEAERKQLQVELQSRRAEL--VCLNNTEISENSSDLSQKLKET 459
Query: 591 EKMKEKAEKKLMSVKSE--LDTTEHEAKENKERARNMIEVVTSEMKTLKK----SLEEAE 644
+ E+A K+++SV+ + L E+ +N + V E+ LK+ +LEE+E
Sbjct: 460 QSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHEL-RVTEEEINVLKQDLQNALEESE 518
Query: 645 KREKQLADFREVVSQMLGLNVTSLALPDYEIIK 677
+ ++++ + E + + V + +YE +K
Sbjct: 519 RNKEKVRELEEKLVEREKGTVIKPPVEEYEEMK 551
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 98.6 bits (244), Expect = 2e-20
Identities = 142/679 (20%), Positives = 288/679 (42%), Gaps = 105/679 (15%)
Query: 20 ETYDHLSEVPVTREQLNHYRNVA--QNARSELAATLVKFECAQSELQDLRSKMLSKEVSC 77
E D LS+ + L + A Q+ S L A + ELQD K+ +K
Sbjct: 321 ENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQD---KLQAKSPKE 377
Query: 78 QELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELK 137
E +SY S T L + + E S SK + H+ K +
Sbjct: 378 AEADLSFDSYH-------STQTDLGPSLGKPGETSPP--DSKSSPSVLIHSLGKSTTDND 428
Query: 138 KKVVELNEKLQKCSKE---NEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLI 194
++ +L E LQ K +E +KQ+ + L CL+ E ++ +SD L
Sbjct: 429 VRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELV----CLNNTEISENSSD--LS 482
Query: 195 LKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEK- 253
KL++ + + E +++ +++ + + + + S N TEE+
Sbjct: 483 QKLKETQSKYEEAMKEVLSVQKQMKLGLVSPE----------SMDNYSHFHELRVTEEEI 532
Query: 254 EKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQ 313
L QDL +A+E E + +V+ +E+L+ +++ +++K E E+ +K+S
Sbjct: 533 NVLKQDLQNALEESERNKEKVRELEEKLV--------EREKGTVIKPPVEEYEE-MKSSY 583
Query: 314 DAVTTSQSQYFSFR-EKIAALLRGRLSMTGSTEDTILEKIR-EMDSREESRDRMVSQLEA 371
+V + ++ +F EK + + + + + ++ E + +E+ +RM+ +L
Sbjct: 584 CSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNK 643
Query: 372 QISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTH---LEAELVSGGVLRDNLNFE 428
Q+SEL QL KE+ + ++ + E++ + H ++ VS D L+
Sbjct: 644 QVSEL-SQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEM 702
Query: 429 KQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQR 488
K +Y K L++L+Q +L D + + ++ TE L + +T A ++
Sbjct: 703 KSQYSKVLNELTQLKQL--------VDAQKENSVSITEHL-----QVITTLRTAAKEMEE 749
Query: 489 KLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVV---------------------- 526
K+ KE L SKE+ ++ L + QL EEK A T +V
Sbjct: 750 KISNLKEHLASKEVEVAKLEK---QLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASK 806
Query: 527 ------ERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAI 580
E++ H + ++ +V ++++E ++ T LK+K + NEL K + + +
Sbjct: 807 LKESVKEKEKVHSEVVQIRSEVSQVKREKE---NIQTLLKSKEQEVNELLQKFQQAQEEL 863
Query: 581 EDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHE---------AKENKERARNMIEVVTS 631
++ + + K++E +KK+ + E+ + + + +R +E +
Sbjct: 864 AEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQ 923
Query: 632 EMKTLKKSLEEAEKREKQL 650
++K L+ L E +K+ +++
Sbjct: 924 QVKQLQNQLAECKKQHQEV 942
Score = 75.9 bits (185), Expect = 1e-13
Identities = 101/459 (22%), Positives = 195/459 (42%), Gaps = 72/459 (15%)
Query: 3 LDCTSHIALGAASPAPEETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSE 62
L + LG SP + Y H E+ VT E++N + QNA L + E + +
Sbjct: 500 LSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNA-------LEESERNKEK 552
Query: 63 LQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLR-------DRVQELEEESAAL 115
+++L K++ +E +K +E Y+E + S++ ++ ++ QE +EE L
Sbjct: 553 VRELEEKLVEREKG-TVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKL 611
Query: 116 STSKIRTEITAHAA-----IKEN-----QELKKKVVELNEKLQKCSKENEENKKQVSK-- 163
+ +++++T A+ +KE EL K+V EL++ ++ E E+ +K+ S
Sbjct: 612 KDT-LKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLED 670
Query: 164 ------NCRKHEEF--LTQLRDCLDPDERNDKASDEDLIL-------KLRDLRKEN--EF 206
+ +HE+ LT + D ++ S +L +L D +KEN
Sbjct: 671 VTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSI 730
Query: 207 VKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLL---SA 263
+ VI EME K S LAS+ K EEK + ++ S
Sbjct: 731 TEHLQVITTLRTAAKEMEEKIS-NLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 789
Query: 264 VEAKEALEREVKIFQERLLAGQQVWD-------ASKQEVSLLKKSSSELEKSLKASQDAV 316
+ + +LE EV + +L + + + EVS +K+ ++ LK+ + V
Sbjct: 790 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV 849
Query: 317 TTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISEL 376
++ +E++A + R S + EE +D+ ++++ ++++L
Sbjct: 850 NELLQKFQQAQEELAEMKRYAESSS---------------KLEEDKDKKINEMSKEVTKL 894
Query: 377 VEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAEL 415
E L S + +++ LE LQ Q+ L+ +L
Sbjct: 895 KEALNSLSQL-SYSTSSSKRQSQQLEALQQQVKQLQNQL 932
Score = 67.0 bits (162), Expect = 6e-11
Identities = 125/575 (21%), Positives = 247/575 (42%), Gaps = 81/575 (14%)
Query: 54 VKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESA 113
V+ + Q LQDL+ ++ S E ++L+ E++S + L L + E+ E S+
Sbjct: 429 VRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAE-------LVCLNNT--EISENSS 479
Query: 114 ALSTSKIRTEITAHAAIKENQELKKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLT 173
LS T+ A+KE ++K++ KL S E+ +N + EE
Sbjct: 480 DLSQKLKETQSKYEEAMKEVLSVQKQM-----KLGLVSPESMDNYSHFHELRVTEEEINV 534
Query: 174 ---QLRDCLDPDERNDKASDEDLILKLRDLRKEN-EFVKGQIVILEETINVHEMEAKASR 229
L++ L+ ERN + K+R+L ++ E KG ++ + + +E E K+S
Sbjct: 535 LKQDLQNALEESERNKE--------KVRELEEKLVEREKGTVI--KPPVEEYE-EMKSSY 583
Query: 230 ETIMRLASEVNREQ----KKAASCTEEKEKLNQDLLSAVEAKEALERE-VKIFQERLL-- 282
+++ +N+E+ +K EE KL L S + + + E E +K R++
Sbjct: 584 CSVIE---NMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDE 640
Query: 283 AGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTG 342
+QV + S+ L K++ +ELE K T++ + + EK+ + +T
Sbjct: 641 LNKQVSELSQ----LYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKL-------MQLTN 689
Query: 343 STEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLE 402
+ + + EM S+ ++QL+ + E + Q A+ M E
Sbjct: 690 VSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE 749
Query: 403 TLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVL 462
+ HL ++ V L L EK D + + +++ + L + + V+
Sbjct: 750 KISNLKEHLASKEVEVAKLEKQLLEEKAA---MTDAMVPRSSYEKLQSSL--ESEVSVLA 804
Query: 463 ARTEQLVRLESNA---VIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEE-- 517
++ ++ V+ + V++ ++ ++R+ + + L+SKE ++ L QK Q +EE
Sbjct: 805 SKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELA 864
Query: 518 ---KQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKT- 573
+ A ++ +E D KK+ + KE+ T+LK L ++L T
Sbjct: 865 EMKRYAESSSKLEEDK--------DKKINEMSKEV-------TKLKEALNSLSQLSYSTS 909
Query: 574 --LEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKS 606
Q++ +E L + QL+ + +K+ V S
Sbjct: 910 SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVIS 944
Score = 38.9 bits (89), Expect = 0.017
Identities = 35/153 (22%), Positives = 77/153 (50%), Gaps = 13/153 (8%)
Query: 535 IRNLQKKVERLQKELNTC----RDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQL 590
I+ LQ+ ++ LQK L + + L EL+++ A+ + + E ++ DL++ +
Sbjct: 431 IQQLQEILQDLQKRLESSEAERKQLQVELQSRRAEL--VCLNNTEISENSSDLSQKLKET 488
Query: 591 EKMKEKAEKKLMSVKSE--LDTTEHEAKENKERARNMIEVVTSEMKTLKK----SLEEAE 644
+ E+A K+++SV+ + L E+ +N + V E+ LK+ +LEE+E
Sbjct: 489 QSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHEL-RVTEEEINVLKQDLQNALEESE 547
Query: 645 KREKQLADFREVVSQMLGLNVTSLALPDYEIIK 677
+ ++++ + E + + V + +YE +K
Sbjct: 548 RNKEKVRELEEKLVEREKGTVIKPPVEEYEEMK 580
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 98.6 bits (244), Expect = 2e-20
Identities = 142/679 (20%), Positives = 288/679 (42%), Gaps = 105/679 (15%)
Query: 20 ETYDHLSEVPVTREQLNHYRNVA--QNARSELAATLVKFECAQSELQDLRSKMLSKEVSC 77
E D LS+ + L + A Q+ S L A + ELQD K+ +K
Sbjct: 321 ENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQD---KLQAKSPKE 377
Query: 78 QELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELK 137
E +SY S T L + + E S SK + H+ K +
Sbjct: 378 AEADLSFDSYH-------STQTDLGPSLGKPGETSPP--DSKSSPSVLIHSLGKSTTDND 428
Query: 138 KKVVELNEKLQKCSKE---NEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLI 194
++ +L E LQ K +E +KQ+ + L CL+ E ++ +SD L
Sbjct: 429 VRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELV----CLNNTEISENSSD--LS 482
Query: 195 LKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEK- 253
KL++ + + E +++ +++ + + + + S N TEE+
Sbjct: 483 QKLKETQSKYEEAMKEVLSVQKQMKLGLVSPE----------SMDNYSHFHELRVTEEEI 532
Query: 254 EKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQ 313
L QDL +A+E E + +V+ +E+L+ +++ +++K E E+ +K+S
Sbjct: 533 NVLKQDLQNALEESERNKEKVRELEEKLV--------EREKGTVIKPPVEEYEE-MKSSY 583
Query: 314 DAVTTSQSQYFSFR-EKIAALLRGRLSMTGSTEDTILEKIR-EMDSREESRDRMVSQLEA 371
+V + ++ +F EK + + + + + ++ E + +E+ +RM+ +L
Sbjct: 584 CSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNK 643
Query: 372 QISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTH---LEAELVSGGVLRDNLNFE 428
Q+SEL QL KE+ + ++ + E++ + H ++ VS D L+
Sbjct: 644 QVSEL-SQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEM 702
Query: 429 KQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQR 488
K +Y K L++L+Q +L D + + ++ TE L + +T A ++
Sbjct: 703 KSQYSKVLNELTQLKQL--------VDAQKENSVSITEHL-----QVITTLRTAAKEMEE 749
Query: 489 KLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVV---------------------- 526
K+ KE L SKE+ ++ L + QL EEK A T +V
Sbjct: 750 KISNLKEHLASKEVEVAKLEK---QLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASK 806
Query: 527 ------ERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAI 580
E++ H + ++ +V ++++E ++ T LK+K + NEL K + + +
Sbjct: 807 LKESVKEKEKVHSEVVQIRSEVSQVKREKE---NIQTLLKSKEQEVNELLQKFQQAQEEL 863
Query: 581 EDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHE---------AKENKERARNMIEVVTS 631
++ + + K++E +KK+ + E+ + + + +R +E +
Sbjct: 864 AEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQ 923
Query: 632 EMKTLKKSLEEAEKREKQL 650
++K L+ L E +K+ +++
Sbjct: 924 QVKQLQNQLAECKKQHQEV 942
Score = 75.9 bits (185), Expect = 1e-13
Identities = 101/459 (22%), Positives = 195/459 (42%), Gaps = 72/459 (15%)
Query: 3 LDCTSHIALGAASPAPEETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSE 62
L + LG SP + Y H E+ VT E++N + QNA L + E + +
Sbjct: 500 LSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNA-------LEESERNKEK 552
Query: 63 LQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLR-------DRVQELEEESAAL 115
+++L K++ +E +K +E Y+E + S++ ++ ++ QE +EE L
Sbjct: 553 VRELEEKLVEREKG-TVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKL 611
Query: 116 STSKIRTEITAHAA-----IKEN-----QELKKKVVELNEKLQKCSKENEENKKQVSK-- 163
+ +++++T A+ +KE EL K+V EL++ ++ E E+ +K+ S
Sbjct: 612 KDT-LKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLED 670
Query: 164 ------NCRKHEEF--LTQLRDCLDPDERNDKASDEDLIL-------KLRDLRKEN--EF 206
+ +HE+ LT + D ++ S +L +L D +KEN
Sbjct: 671 VTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSI 730
Query: 207 VKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLL---SA 263
+ VI EME K S LAS+ K EEK + ++ S
Sbjct: 731 TEHLQVITTLRTAAKEMEEKIS-NLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 789
Query: 264 VEAKEALEREVKIFQERLLAGQQVWD-------ASKQEVSLLKKSSSELEKSLKASQDAV 316
+ + +LE EV + +L + + + EVS +K+ ++ LK+ + V
Sbjct: 790 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV 849
Query: 317 TTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISEL 376
++ +E++A + R S + EE +D+ ++++ ++++L
Sbjct: 850 NELLQKFQQAQEELAEMKRYAESSS---------------KLEEDKDKKINEMSKEVTKL 894
Query: 377 VEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAEL 415
E L S + +++ LE LQ Q+ L+ +L
Sbjct: 895 KEALNSLSQL-SYSTSSSKRQSQQLEALQQQVKQLQNQL 932
Score = 67.0 bits (162), Expect = 6e-11
Identities = 125/575 (21%), Positives = 247/575 (42%), Gaps = 81/575 (14%)
Query: 54 VKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESA 113
V+ + Q LQDL+ ++ S E ++L+ E++S + L L + E+ E S+
Sbjct: 429 VRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAE-------LVCLNNT--EISENSS 479
Query: 114 ALSTSKIRTEITAHAAIKENQELKKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLT 173
LS T+ A+KE ++K++ KL S E+ +N + EE
Sbjct: 480 DLSQKLKETQSKYEEAMKEVLSVQKQM-----KLGLVSPESMDNYSHFHELRVTEEEINV 534
Query: 174 ---QLRDCLDPDERNDKASDEDLILKLRDLRKEN-EFVKGQIVILEETINVHEMEAKASR 229
L++ L+ ERN + K+R+L ++ E KG ++ + + +E E K+S
Sbjct: 535 LKQDLQNALEESERNKE--------KVRELEEKLVEREKGTVI--KPPVEEYE-EMKSSY 583
Query: 230 ETIMRLASEVNREQ----KKAASCTEEKEKLNQDLLSAVEAKEALERE-VKIFQERLL-- 282
+++ +N+E+ +K EE KL L S + + + E E +K R++
Sbjct: 584 CSVIE---NMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDE 640
Query: 283 AGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTG 342
+QV + S+ L K++ +ELE K T++ + + EK+ + +T
Sbjct: 641 LNKQVSELSQ----LYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKL-------MQLTN 689
Query: 343 STEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLE 402
+ + + EM S+ ++QL+ + E + Q A+ M E
Sbjct: 690 VSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE 749
Query: 403 TLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVL 462
+ HL ++ V L L EK D + + +++ + L + + V+
Sbjct: 750 KISNLKEHLASKEVEVAKLEKQLLEEKAA---MTDAMVPRSSYEKLQSSL--ESEVSVLA 804
Query: 463 ARTEQLVRLESNA---VIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEE-- 517
++ ++ V+ + V++ ++ ++R+ + + L+SKE ++ L QK Q +EE
Sbjct: 805 SKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELA 864
Query: 518 ---KQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKT- 573
+ A ++ +E D KK+ + KE+ T+LK L ++L T
Sbjct: 865 EMKRYAESSSKLEEDK--------DKKINEMSKEV-------TKLKEALNSLSQLSYSTS 909
Query: 574 --LEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKS 606
Q++ +E L + QL+ + +K+ V S
Sbjct: 910 SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVIS 944
Score = 38.9 bits (89), Expect = 0.017
Identities = 35/153 (22%), Positives = 77/153 (50%), Gaps = 13/153 (8%)
Query: 535 IRNLQKKVERLQKELNTC----RDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQL 590
I+ LQ+ ++ LQK L + + L EL+++ A+ + + E ++ DL++ +
Sbjct: 431 IQQLQEILQDLQKRLESSEAERKQLQVELQSRRAEL--VCLNNTEISENSSDLSQKLKET 488
Query: 591 EKMKEKAEKKLMSVKSE--LDTTEHEAKENKERARNMIEVVTSEMKTLKK----SLEEAE 644
+ E+A K+++SV+ + L E+ +N + V E+ LK+ +LEE+E
Sbjct: 489 QSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHEL-RVTEEEINVLKQDLQNALEESE 547
Query: 645 KREKQLADFREVVSQMLGLNVTSLALPDYEIIK 677
+ ++++ + E + + V + +YE +K
Sbjct: 548 RNKEKVRELEEKLVEREKGTVIKPPVEEYEEMK 580
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 98.6 bits (244), Expect = 2e-20
Identities = 142/679 (20%), Positives = 288/679 (42%), Gaps = 105/679 (15%)
Query: 20 ETYDHLSEVPVTREQLNHYRNVA--QNARSELAATLVKFECAQSELQDLRSKMLSKEVSC 77
E D LS+ + L + A Q+ S L A + ELQD K+ +K
Sbjct: 321 ENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQD---KLQAKSPKE 377
Query: 78 QELKAEMESYKENNARKSSLLTSLRDRVQELEEESAALSTSKIRTEITAHAAIKENQELK 137
E +SY S T L + + E S SK + H+ K +
Sbjct: 378 AEADLSFDSYH-------STQTDLGPSLGKPGETSPP--DSKSSPSVLIHSLGKSTTDND 428
Query: 138 KKVVELNEKLQKCSKE---NEENKKQVSKNCRKHEEFLTQLRDCLDPDERNDKASDEDLI 194
++ +L E LQ K +E +KQ+ + L CL+ E ++ +SD L
Sbjct: 429 VRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELV----CLNNTEISENSSD--LS 482
Query: 195 LKLRDLRKENEFVKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEK- 253
KL++ + + E +++ +++ + + + + S N TEE+
Sbjct: 483 QKLKETQSKYEEAMKEVLSVQKQMKLGLVSPE----------SMDNYSHFHELRVTEEEI 532
Query: 254 EKLNQDLLSAVEAKEALEREVKIFQERLLAGQQVWDASKQEVSLLKKSSSELEKSLKASQ 313
L QDL +A+E E + +V+ +E+L+ +++ +++K E E+ +K+S
Sbjct: 533 NVLKQDLQNALEESERNKEKVRELEEKLV--------EREKGTVIKPPVEEYEE-MKSSY 583
Query: 314 DAVTTSQSQYFSFR-EKIAALLRGRLSMTGSTEDTILEKIR-EMDSREESRDRMVSQLEA 371
+V + ++ +F EK + + + + + ++ E + +E+ +RM+ +L
Sbjct: 584 CSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNK 643
Query: 372 QISELVEQLGKESGFHQKALQRAQKAENMLETLQGQLTH---LEAELVSGGVLRDNLNFE 428
Q+SEL QL KE+ + ++ + E++ + H ++ VS D L+
Sbjct: 644 QVSEL-SQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEM 702
Query: 429 KQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVLARTEQLVRLESNAVIENKTIAHNLQR 488
K +Y K L++L+Q +L D + + ++ TE L + +T A ++
Sbjct: 703 KSQYSKVLNELTQLKQL--------VDAQKENSVSITEHL-----QVITTLRTAAKEMEE 749
Query: 489 KLKTQKERLESKELHMSLLRQKIAQLEEEKQARTALVV---------------------- 526
K+ KE L SKE+ ++ L + QL EEK A T +V
Sbjct: 750 KISNLKEHLASKEVEVAKLEK---QLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASK 806
Query: 527 ------ERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKTLEQTKAI 580
E++ H + ++ +V ++++E ++ T LK+K + NEL K + + +
Sbjct: 807 LKESVKEKEKVHSEVVQIRSEVSQVKREKE---NIQTLLKSKEQEVNELLQKFQQAQEEL 863
Query: 581 EDLNKSRDQLEKMKEKAEKKLMSVKSELDTTEHE---------AKENKERARNMIEVVTS 631
++ + + K++E +KK+ + E+ + + + +R +E +
Sbjct: 864 AEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQ 923
Query: 632 EMKTLKKSLEEAEKREKQL 650
++K L+ L E +K+ +++
Sbjct: 924 QVKQLQNQLAECKKQHQEV 942
Score = 75.9 bits (185), Expect = 1e-13
Identities = 101/459 (22%), Positives = 195/459 (42%), Gaps = 72/459 (15%)
Query: 3 LDCTSHIALGAASPAPEETYDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSE 62
L + LG SP + Y H E+ VT E++N + QNA L + E + +
Sbjct: 500 LSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNA-------LEESERNKEK 552
Query: 63 LQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLR-------DRVQELEEESAAL 115
+++L K++ +E +K +E Y+E + S++ ++ ++ QE +EE L
Sbjct: 553 VRELEEKLVEREKG-TVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKL 611
Query: 116 STSKIRTEITAHAA-----IKEN-----QELKKKVVELNEKLQKCSKENEENKKQVSK-- 163
+ +++++T A+ +KE EL K+V EL++ ++ E E+ +K+ S
Sbjct: 612 KDT-LKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLED 670
Query: 164 ------NCRKHEEF--LTQLRDCLDPDERNDKASDEDLIL-------KLRDLRKEN--EF 206
+ +HE+ LT + D ++ S +L +L D +KEN
Sbjct: 671 VTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSI 730
Query: 207 VKGQIVILEETINVHEMEAKASRETIMRLASEVNREQKKAASCTEEKEKLNQDLL---SA 263
+ VI EME K S LAS+ K EEK + ++ S
Sbjct: 731 TEHLQVITTLRTAAKEMEEKIS-NLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSY 789
Query: 264 VEAKEALEREVKIFQERLLAGQQVWD-------ASKQEVSLLKKSSSELEKSLKASQDAV 316
+ + +LE EV + +L + + + EVS +K+ ++ LK+ + V
Sbjct: 790 EKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEV 849
Query: 317 TTSQSQYFSFREKIAALLRGRLSMTGSTEDTILEKIREMDSREESRDRMVSQLEAQISEL 376
++ +E++A + R S + EE +D+ ++++ ++++L
Sbjct: 850 NELLQKFQQAQEELAEMKRYAESSS---------------KLEEDKDKKINEMSKEVTKL 894
Query: 377 VEQLGKESGFHQKALQRAQKAENMLETLQGQLTHLEAEL 415
E L S + +++ LE LQ Q+ L+ +L
Sbjct: 895 KEALNSLSQL-SYSTSSSKRQSQQLEALQQQVKQLQNQL 932
Score = 67.0 bits (162), Expect = 6e-11
Identities = 125/575 (21%), Positives = 247/575 (42%), Gaps = 81/575 (14%)
Query: 54 VKFECAQSELQDLRSKMLSKEVSCQELKAEMESYKENNARKSSLLTSLRDRVQELEEESA 113
V+ + Q LQDL+ ++ S E ++L+ E++S + L L + E+ E S+
Sbjct: 429 VRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAE-------LVCLNNT--EISENSS 479
Query: 114 ALSTSKIRTEITAHAAIKENQELKKKVVELNEKLQKCSKENEENKKQVSKNCRKHEEFLT 173
LS T+ A+KE ++K++ KL S E+ +N + EE
Sbjct: 480 DLSQKLKETQSKYEEAMKEVLSVQKQM-----KLGLVSPESMDNYSHFHELRVTEEEINV 534
Query: 174 ---QLRDCLDPDERNDKASDEDLILKLRDLRKEN-EFVKGQIVILEETINVHEMEAKASR 229
L++ L+ ERN + K+R+L ++ E KG ++ + + +E E K+S
Sbjct: 535 LKQDLQNALEESERNKE--------KVRELEEKLVEREKGTVI--KPPVEEYE-EMKSSY 583
Query: 230 ETIMRLASEVNREQ----KKAASCTEEKEKLNQDLLSAVEAKEALERE-VKIFQERLL-- 282
+++ +N+E+ +K EE KL L S + + + E E +K R++
Sbjct: 584 CSVIE---NMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDE 640
Query: 283 AGQQVWDASKQEVSLLKKSSSELEKSLKASQDAVTTSQSQYFSFREKIAALLRGRLSMTG 342
+QV + S+ L K++ +ELE K T++ + + EK+ + +T
Sbjct: 641 LNKQVSELSQ----LYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKL-------MQLTN 689
Query: 343 STEDTILEKIREMDSREESRDRMVSQLEAQISELVEQLGKESGFHQKALQRAQKAENMLE 402
+ + + EM S+ ++QL+ + E + Q A+ M E
Sbjct: 690 VSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE 749
Query: 403 TLQGQLTHLEAELVSGGVLRDNLNFEKQKYLKFLDQLSQKMKLDQMAAELGFDMRLDVVL 462
+ HL ++ V L L EK D + + +++ + L + + V+
Sbjct: 750 KISNLKEHLASKEVEVAKLEKQLLEEKAA---MTDAMVPRSSYEKLQSSL--ESEVSVLA 804
Query: 463 ARTEQLVRLESNA---VIENKTIAHNLQRKLKTQKERLESKELHMSLLRQKIAQLEEE-- 517
++ ++ V+ + V++ ++ ++R+ + + L+SKE ++ L QK Q +EE
Sbjct: 805 SKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELA 864
Query: 518 ---KQARTALVVERDNAHLTIRNLQKKVERLQKELNTCRDLHTELKAKLADTNELKIKT- 573
+ A ++ +E D KK+ + KE+ T+LK L ++L T
Sbjct: 865 EMKRYAESSSKLEEDK--------DKKINEMSKEV-------TKLKEALNSLSQLSYSTS 909
Query: 574 --LEQTKAIEDLNKSRDQLEKMKEKAEKKLMSVKS 606
Q++ +E L + QL+ + +K+ V S
Sbjct: 910 SSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVIS 944
Score = 38.9 bits (89), Expect = 0.017
Identities = 35/153 (22%), Positives = 77/153 (50%), Gaps = 13/153 (8%)
Query: 535 IRNLQKKVERLQKELNTC----RDLHTELKAKLADTNELKIKTLEQTKAIEDLNKSRDQL 590
I+ LQ+ ++ LQK L + + L EL+++ A+ + + E ++ DL++ +
Sbjct: 431 IQQLQEILQDLQKRLESSEAERKQLQVELQSRRAEL--VCLNNTEISENSSDLSQKLKET 488
Query: 591 EKMKEKAEKKLMSVKSE--LDTTEHEAKENKERARNMIEVVTSEMKTLKK----SLEEAE 644
+ E+A K+++SV+ + L E+ +N + V E+ LK+ +LEE+E
Sbjct: 489 QSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHEL-RVTEEEINVLKQDLQNALEESE 547
Query: 645 KREKQLADFREVVSQMLGLNVTSLALPDYEIIK 677
+ ++++ + E + + V + +YE +K
Sbjct: 548 RNKEKVRELEEKLVEREKGTVIKPPVEEYEEMK 580
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.124 0.321
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,007,229
Number of Sequences: 37866
Number of extensions: 925446
Number of successful extensions: 16297
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 407
Number of HSP's successfully gapped in prelim test: 1152
Number of HSP's that attempted gapping in prelim test: 6271
Number of HSP's gapped (non-prelim): 5768
length of query: 715
length of database: 18,247,518
effective HSP length: 109
effective length of query: 606
effective length of database: 14,120,124
effective search space: 8556795144
effective search space used: 8556795144
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.