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Search of human proteins with 38505170
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38505170 Ras protein-specific guanine nucleotide-releasing
factor 2 [Homo sapiens]
(1237 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 2474 0.0
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 1649 0.0
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 1634 0.0
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 555 e-158
gi|154689780 son of sevenless homolog 2 [Homo sapiens] 147 5e-35
gi|15529996 son of sevenless homolog 1 [Homo sapiens] 147 6e-35
gi|93102367 ral guanine nucleotide dissociation stimulator-like ... 130 8e-30
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 129 2e-29
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 129 2e-29
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 129 2e-29
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 124 6e-28
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 124 6e-28
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 124 6e-28
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ... 123 9e-28
gi|239582765 ral guanine nucleotide dissociation stimulator-like... 120 6e-27
gi|239582763 ral guanine nucleotide dissociation stimulator-like... 120 6e-27
gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Hom... 112 2e-24
gi|24307909 ral guanine nucleotide dissociation stimulator isofo... 107 5e-23
gi|108796058 ral guanine nucleotide dissociation stimulator isof... 107 5e-23
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 107 9e-23
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 107 9e-23
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 103 1e-21
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 103 1e-21
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] 102 2e-21
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] 102 2e-21
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens] 102 2e-21
gi|4758532 ral guanine nucleotide dissociation stimulator-like 2... 97 7e-20
gi|22749129 RasGEF domain family, member 1B [Homo sapiens] 92 2e-18
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 92 3e-18
gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [... 92 4e-18
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 2474 bits (6412), Expect = 0.0
Identities = 1237/1237 (100%), Positives = 1237/1237 (100%)
Query: 1 MQKSVRYNEGHALYLAFLARKEGTKRGFLSKKTAEASRWHEKWFALYQNVLFYFEGEQSC 60
MQKSVRYNEGHALYLAFLARKEGTKRGFLSKKTAEASRWHEKWFALYQNVLFYFEGEQSC
Sbjct: 1 MQKSVRYNEGHALYLAFLARKEGTKRGFLSKKTAEASRWHEKWFALYQNVLFYFEGEQSC 60
Query: 61 RPAGMYLLEGCSCERTPAPPRAGAGQGGVRDALDKQYYFTVLFGHEGQKPLELRCEEEQD 120
RPAGMYLLEGCSCERTPAPPRAGAGQGGVRDALDKQYYFTVLFGHEGQKPLELRCEEEQD
Sbjct: 61 RPAGMYLLEGCSCERTPAPPRAGAGQGGVRDALDKQYYFTVLFGHEGQKPLELRCEEEQD 120
Query: 121 GKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIAANQLRHQLEDQDTEIERLKS 180
GKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIAANQLRHQLEDQDTEIERLKS
Sbjct: 121 GKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIAANQLRHQLEDQDTEIERLKS 180
Query: 181 EIIALNKTKERMRPYQSNQEDEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAES 240
EIIALNKTKERMRPYQSNQEDEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAES
Sbjct: 181 EIIALNKTKERMRPYQSNQEDEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAES 240
Query: 241 MRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSETIM 300
MRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSETIM
Sbjct: 241 MRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSETIM 300
Query: 301 FLHEIFHQGLKARIANWPTLILADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFD 360
FLHEIFHQGLKARIANWPTLILADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFD
Sbjct: 301 FLHEIFHQGLKARIANWPTLILADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFD 360
Query: 361 KLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLE 420
KLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLE
Sbjct: 361 KLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLE 420
Query: 421 ELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSKV 480
ELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSKV
Sbjct: 421 ELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSKV 480
Query: 481 RLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIDCTLIEEPDASDDDS 540
RLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIDCTLIEEPDASDDDS
Sbjct: 481 RLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIDCTLIEEPDASDDDS 540
Query: 541 KGSGQVFGHLDFKIVVEPPDAAAFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVF 600
KGSGQVFGHLDFKIVVEPPDAAAFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVF
Sbjct: 541 KGSGQVFGHLDFKIVVEPPDAAAFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVF 600
Query: 601 EENSKVTVPHMIKSDARLHKDDTDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSID 660
EENSKVTVPHMIKSDARLHKDDTDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSID
Sbjct: 601 EENSKVTVPHMIKSDARLHKDDTDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSID 660
Query: 661 FLNTFLHTYRIFTTAAVVLGKLSDIYKRPFTSIPVRSLELFFATSQNNRGEHLVDGKSPR 720
FLNTFLHTYRIFTTAAVVLGKLSDIYKRPFTSIPVRSLELFFATSQNNRGEHLVDGKSPR
Sbjct: 661 FLNTFLHTYRIFTTAAVVLGKLSDIYKRPFTSIPVRSLELFFATSQNNRGEHLVDGKSPR 720
Query: 721 LCRKFSSPPPLAVSRTSSPVRARKLSLTSPLNSKIGALDLTTSSSPTTTTQSPAASPPPH 780
LCRKFSSPPPLAVSRTSSPVRARKLSLTSPLNSKIGALDLTTSSSPTTTTQSPAASPPPH
Sbjct: 721 LCRKFSSPPPLAVSRTSSPVRARKLSLTSPLNSKIGALDLTTSSSPTTTTQSPAASPPPH 780
Query: 781 TGQIPLDLSRGLSSPEQSPGTVEENVDNPRVDLCNKLKRSIQKAVLESAPADRAGVESSP 840
TGQIPLDLSRGLSSPEQSPGTVEENVDNPRVDLCNKLKRSIQKAVLESAPADRAGVESSP
Sbjct: 781 TGQIPLDLSRGLSSPEQSPGTVEENVDNPRVDLCNKLKRSIQKAVLESAPADRAGVESSP 840
Query: 841 AADTTELSPCRSPSTPRHLRYRQPGGQTADNAHCSVSPASAFAIATAAAGHGSPPGFNNT 900
AADTTELSPCRSPSTPRHLRYRQPGGQTADNAHCSVSPASAFAIATAAAGHGSPPGFNNT
Sbjct: 841 AADTTELSPCRSPSTPRHLRYRQPGGQTADNAHCSVSPASAFAIATAAAGHGSPPGFNNT 900
Query: 901 ERTCDKEFIIRRTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQE 960
ERTCDKEFIIRRTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQE
Sbjct: 901 ERTCDKEFIIRRTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQE 960
Query: 961 RKAAANILRALSQDDQDDIHLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRS 1020
RKAAANILRALSQDDQDDIHLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRS
Sbjct: 961 RKAAANILRALSQDDQDDIHLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRS 1020
Query: 1021 IPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAV 1080
IPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAV
Sbjct: 1021 IPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAV 1080
Query: 1081 ADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLR 1140
ADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLR
Sbjct: 1081 ADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLR 1140
Query: 1141 ETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSY 1200
ETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSY
Sbjct: 1141 ETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSY 1200
Query: 1201 RIDHQPKVAQYLLDKDLIIDEDTLYELSLKIEPRLPA 1237
RIDHQPKVAQYLLDKDLIIDEDTLYELSLKIEPRLPA
Sbjct: 1201 RIDHQPKVAQYLLDKDLIIDEDTLYELSLKIEPRLPA 1237
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 1649 bits (4269), Expect = 0.0
Identities = 839/1270 (66%), Positives = 1008/1270 (79%), Gaps = 48/1270 (3%)
Query: 1 MQKSVRYNEGHALYLAFLARKEGTKRGFLSKKTAEASRWHEKWFALYQNVLFYFEGEQSC 60
MQK +R N+GH L LARK+GT++G+LSK++++ ++W KWFAL QN+LFYFE + S
Sbjct: 1 MQKGIRLNDGHVASLGLLARKDGTRKGYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSS 60
Query: 61 RPAGMYLLEGCSCERTPAPPRAGAGQGGVRDALDKQYYFTVLFGHEGQKPLELRCEEEQD 120
RP+G+YLLEGC C+R P+P A + ++ L+KQ+YFTV F HE QK LELR E+ +D
Sbjct: 61 RPSGLYLLEGCVCDRAPSPKPALSA----KEPLEKQHYFTVNFSHENQKALELRTEDAKD 116
Query: 121 GKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIAANQLRHQLEDQDTEIERLKS 180
EW+ AI ASY + E E LMQKY+HL+QIVETEK A QLR Q+ED + EIERLK+
Sbjct: 117 CDEWVAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKA 176
Query: 181 EIIALNKTKERMRPYQS-NQEDEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAE 239
EI +L K ER++ Q+ DED DIKKIKKVQSF+RGWLCRRKWKTI+QDYI SPHA+
Sbjct: 177 EITSLLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHAD 236
Query: 240 SMRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSETI 299
SMRKRNQ+VF+M+EAE+EYV QL+ILVN FLRPLRMAASSKKPPI+HDDVSSIFLNSETI
Sbjct: 237 SMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETI 296
Query: 300 MFLHEIFHQGLKARIANWPTLILADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDF 359
MFLH+IF+QGLKARI++WPTL+LADLFDILLPMLNIYQEFVRNHQYSLQ+LA+CKQNRDF
Sbjct: 297 MFLHQIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDF 356
Query: 360 DKLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKL 419
DKLLK YEA P CE R LETFLTYPMFQIPRYI+TLHELLAHTPHEHVER SL++AKSKL
Sbjct: 357 DKLLKHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKL 416
Query: 420 EELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSK 479
EELSR+MHDEVS+TENIRKNLAIERMI+EGC+ILLDTSQTF+RQGSLIQVP E+GK+++
Sbjct: 417 EELSRIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITR 476
Query: 480 VRLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIDCTLIEEPDASDDD 539
RLGSLSLKKEGERQCFLF+KH +ICTR SGGKLHL K GV+SLIDCTL+EEP++++++
Sbjct: 477 GRLGSLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTK-NGVISLIDCTLLEEPESTEEE 535
Query: 540 SKGSGQVFGHLDFKIVVEPPDAAAFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIV 599
+KGSGQ HLDFKI VEP D+ FTV+L+A SRQEKAAW SDISQCVDNIRCNGLM
Sbjct: 536 AKGSGQDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNA 595
Query: 600 FEENSKVTVPHMIKSDARLHKDDTDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSI 659
FEENSKVTVP MIKSDA L+ DD DI FSKT+NSCKV QIRYASVERLLERLTDLRFLSI
Sbjct: 596 FEENSKVTVPQMIKSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERLTDLRFLSI 655
Query: 660 DFLNTFLHTYRIFTTAAVVLGKLSDIYKRPFTSIPVRSLELFFATSQNNRGEHLVDGKSP 719
DFLNTFLH+YR+FTTA VVL KL IYK+P ++IP RSLEL FA+ QNN+ + KSP
Sbjct: 656 DFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPARSLELLFASGQNNKLLYGEPPKSP 715
Query: 720 RLCRKFSSPPPLAVSRTSSPVRARKLSLTSPLNSKIGALDLTTSSSPTT------TTQSP 773
R RKFSSPPPL++++TSSP R RKLSL P+ + ALDL S + + SP
Sbjct: 716 RATRKFSSPPPLSITKTSSPSRRRKLSLNIPIITGGKALDLAALSCNSNGYTSMYSAMSP 775
Query: 774 AASPPPHTGQIPLDLSRGLSSPEQSPGTVEENVDNPRVDLCNKLKRSIQKAVLESAPADR 833
+ T ++ + S P++ T E+ D + K+S + ++ E + D+
Sbjct: 776 FSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALS-----KQSSEVSMREESDIDQ 830
Query: 834 AGVESSPAADTTELSPCRSPSTPRHLRYRQPGG---------------QTADNAHCSVSP 878
S D TE SP +SP+TP+ ++ + + DN ++S
Sbjct: 831 ---NQSDDGD-TETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSA 886
Query: 879 ASAFAIATAAAGHGSP------------PGFNNTERTCDKEFIIRRTATNRVLNVLRHWV 926
ASAFAIATA A G+P GF +R DKEF+IRR ATNRVLNVLRHWV
Sbjct: 887 ASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWV 946
Query: 927 SKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRALSQDDQDDIHLKLEDI 986
SKH+QDFE N+ELK V+ LEEV+ DP+LL QERKAAANI+R L+Q+D D + LE+I
Sbjct: 947 SKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLEEI 1006
Query: 987 IQMTDCMKAECFESLSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKT 1046
QM + +KAE FE+ SA+E+AEQ+TLLDH++F+ IPYEEF GQGWMKL+KNERTPYIMKT
Sbjct: 1007 TQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKT 1066
Query: 1047 SQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIY 1106
++HFND+SNL+AS+I+ D+++R +AIEKWVAVADICRCLHNYN VLEITS++NRSAI+
Sbjct: 1067 TKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIF 1126
Query: 1107 RLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEE 1166
RLKKTW KVSKQTKAL+DKLQK VSSEGRFKNLRE LKNC+PP VPYLGMYLTDLAFIEE
Sbjct: 1127 RLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEE 1186
Query: 1167 GTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQYLLDKDLIIDEDTLYE 1226
GTPN+TE+GLVNFSKMRMISHIIREIRQFQQT+Y+I+HQ KV QYLLD+ ++DE++LYE
Sbjct: 1187 GTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYE 1246
Query: 1227 LSLKIEPRLP 1236
SL+IEP+LP
Sbjct: 1247 SSLRIEPKLP 1256
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 1634 bits (4232), Expect = 0.0
Identities = 839/1286 (65%), Positives = 1009/1286 (78%), Gaps = 64/1286 (4%)
Query: 1 MQKSVRYNEGHALYLAFLARKEGTKRGFLSKKTAEASRWHEKWFALYQNVLFYFEGEQSC 60
MQK +R N+GH L LARK+GT++G+LSK++++ ++W KWFAL QN+LFYFE + S
Sbjct: 1 MQKGIRLNDGHVASLGLLARKDGTRKGYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSS 60
Query: 61 RPAGMYLLEGCSCERTPAPPRAGAGQGGVRDALDKQYYFTVLFGHEGQKPLELRCEEEQD 120
RP+G+YLLEGC C+R P+P A + ++ L+KQ+YFTV F HE QK LELR E+ +D
Sbjct: 61 RPSGLYLLEGCVCDRAPSPKPALSA----KEPLEKQHYFTVNFSHENQKALELRTEDAKD 116
Query: 121 GKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIAANQLRHQLEDQDTEIERLKS 180
EW+ AI ASY + E E LMQKY+HL+QIVETEK A QLR Q+ED + EIERLK+
Sbjct: 117 CDEWVAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKA 176
Query: 181 EIIALNKTKERMRPYQS-NQEDEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAE 239
EI +L K ER++ Q+ DED DIKKIKKVQSF+RGWLCRRKWKTI+QDYI SPHA+
Sbjct: 177 EITSLLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHAD 236
Query: 240 SMRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSETI 299
SMRKRNQ+VF+M+EAE+EYV QL+ILVN FLRPLRMAASSKKPPI+HDDVSSIFLNSETI
Sbjct: 237 SMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETI 296
Query: 300 MFLHEIFHQGLKARIANWPTLILADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDF 359
MFLH+IF+QGLKARI++WPTL+LADLFDILLPMLNIYQEFVRNHQYSLQ+LA+CKQNRDF
Sbjct: 297 MFLHQIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDF 356
Query: 360 DKLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKL 419
DKLLK YEA P CE R LETFLTYPMFQIPRYI+TLHELLAHTPHEHVER SL++AKSKL
Sbjct: 357 DKLLKHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKL 416
Query: 420 EELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSK 479
EELSR+MHDEVS+TENIRKNLAIERMI+EGC+ILLDTSQTF+RQGSLIQVP E+GK+++
Sbjct: 417 EELSRIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITR 476
Query: 480 VRLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIDCTLIEEPDASDDD 539
RLGSLSLKKEGERQCFLF+KH +ICTR SGGKLHL K GV+SLIDCTL+EEP++++++
Sbjct: 477 GRLGSLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTK-NGVISLIDCTLLEEPESTEEE 535
Query: 540 SKGSGQVFGHLDFKIVVEPPDAAAFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIV 599
+KGSGQ HLDFKI VEP D+ FTV+L+A SRQEKAAW SDISQCVDNIRCNGLM
Sbjct: 536 AKGSGQDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNA 595
Query: 600 FEENSKVTVPHMIK-------------SDARLHKDDTDICFSKTLNSCKVPQIRYASVER 646
FEENSKVTVP MIK SDA L+ DD DI FSKT+NSCKV QIRYASVER
Sbjct: 596 FEENSKVTVPQMIKRTREGTREAEMSRSDASLYCDDVDIRFSKTMNSCKVLQIRYASVER 655
Query: 647 LLERLTDLRFLSIDFLNTFLHTYRIFTTAAVVLGKLSDIYKRPFTSIP---VRSLELFFA 703
LLERLTDLRFLSIDFLNTFLH+YR+FTTA VVL KL IYK+P ++IP +RSLEL FA
Sbjct: 656 LLERLTDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPARWLRSLELLFA 715
Query: 704 TSQNNRGEHLVDGKSPRLCRKFSSPPPLAVSRTSSPVRARKLSLTSPLNSKIGALDLTTS 763
+ QNN+ + KSPR RKFSSPPPL++++TSSP R RKLSL P+ + ALDL
Sbjct: 716 SGQNNKLLYGEPPKSPRATRKFSSPPPLSITKTSSPSRRRKLSLNIPIITGGKALDLAAL 775
Query: 764 SSPTT------TTQSPAASPPPHTGQIPLDLSRGLSSPEQSPGTVEENVDNPRVDLCNKL 817
S + + SP + T ++ + S P++ T E+ D +
Sbjct: 776 SCNSNGYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALS----- 830
Query: 818 KRSIQKAVLESAPADRAGVESSPAADTTELSPCRSPSTPRHLRYRQPGG----------- 866
K+S + ++ E + D+ S D TE SP +SP+TP+ ++ +
Sbjct: 831 KQSSEVSMREESDIDQ---NQSDDGD-TETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVV 886
Query: 867 ----QTADNAHCSVSPASAFAIATAAAGHGSP------------PGFNNTERTCDKEFII 910
+ DN ++S ASAFAIATA A G+P GF +R DKEF+I
Sbjct: 887 MTSCRELDNNRSALSAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVI 946
Query: 911 RRTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRA 970
RR ATNRVLNVLRHWVSKH+QDFE N+ELK V+ LEEV+ DP+LL QERKAAANI+R
Sbjct: 947 RRAATNRVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRT 1006
Query: 971 LSQDDQDDIHLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRSIPYEEFLGQG 1030
L+Q+D D + LE+I QM + +KAE FE+ SA+E+AEQ+TLLDH++F+ IPYEEF GQG
Sbjct: 1007 LTQEDPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQG 1066
Query: 1031 WMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNY 1090
WMKL+KNERTPYIMKT++HFND+SNL+AS+I+ D+++R +AIEKWVAVADICRCLHNY
Sbjct: 1067 WMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNY 1126
Query: 1091 NGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPA 1150
N VLEITS++NRSAI+RLKKTW KVSKQTKAL+DKLQK VSSEGRFKNLRE LKNC+PP
Sbjct: 1127 NAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPC 1186
Query: 1151 VPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQ 1210
VPYLGMYLTDLAFIEEGTPN+TE+GLVNFSKMRMISHIIREIRQFQQT+Y+I+HQ KV Q
Sbjct: 1187 VPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQ 1246
Query: 1211 YLLDKDLIIDEDTLYELSLKIEPRLP 1236
YLLD+ ++DE++LYE SL+IEP+LP
Sbjct: 1247 YLLDQSFVMDEESLYESSLRIEPKLP 1272
>gi|24797101 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 2 [Homo sapiens]
Length = 489
Score = 555 bits (1431), Expect = e-158
Identities = 278/445 (62%), Positives = 346/445 (77%), Gaps = 28/445 (6%)
Query: 820 SIQKAVLESAPADRAGVESSPAAD-TTELSPCRSPSTPRHLRYRQPGG------------ 866
++ K E + + + ++ + + D TE SP +SP+TP+ ++ +
Sbjct: 44 ALSKQSSEVSMREESDIDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVM 103
Query: 867 ---QTADNAHCSVSPASAFAIATAAAGHGSP------------PGFNNTERTCDKEFIIR 911
+ DN ++S ASAFAIATA A G+P GF +R DKEF+IR
Sbjct: 104 TSCRELDNNRSALSAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIR 163
Query: 912 RTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRAL 971
R ATNRVLNVLRHWVSKH+QDFE N+ELK V+ LEEV+ DP+LL QERKAAANI+R L
Sbjct: 164 RAATNRVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTL 223
Query: 972 SQDDQDDIHLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRSIPYEEFLGQGW 1031
+Q+D D + LE+I QM + +KAE FE+ SA+E+AEQ+TLLDH++F+ IPYEEF GQGW
Sbjct: 224 TQEDPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGW 283
Query: 1032 MKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYN 1091
MKL+KNERTPYIMKT++HFND+SNL+AS+I+ D+++R +AIEKWVAVADICRCLHNYN
Sbjct: 284 MKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYN 343
Query: 1092 GVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAV 1151
VLEITS++NRSAI+RLKKTW KVSKQTKAL+DKLQK VSSEGRFKNLRE LKNC+PP V
Sbjct: 344 AVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCV 403
Query: 1152 PYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQY 1211
PYLGMYLTDLAFIEEGTPN+TE+GLVNFSKMRMISHIIREIRQFQQT+Y+I+HQ KV QY
Sbjct: 404 PYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQY 463
Query: 1212 LLDKDLIIDEDTLYELSLKIEPRLP 1236
LLD+ ++DE++LYE SL+IEP+LP
Sbjct: 464 LLDQSFVMDEESLYESSLRIEPKLP 488
>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
Length = 1332
Score = 147 bits (372), Expect = 5e-35
Identities = 96/342 (28%), Positives = 172/342 (50%), Gaps = 34/342 (9%)
Query: 917 RVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRALSQDDQ 976
R+LNV RHWV H DFE + EL + + + V + + ++ A I+R Q
Sbjct: 686 RILNVFRHWVEHHFYDFERDLELLERLESFISSVRGKA--MKKWVESIAKIIRRKKQAQA 743
Query: 977 DDI---------------HLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRSI 1021
+ + H+ + D M +L +E+A Q+TLL+ ++R +
Sbjct: 744 NGVSHNITFESPPPPIEWHISKPGQFETFDLM------TLHPIEIARQLTLLESDLYRKV 797
Query: 1022 PYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVA 1081
E +G W K DK +P ++K +H +++ I+ + R + + + +
Sbjct: 798 QPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEIL 857
Query: 1082 DICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRE 1141
+ + L+N+NGVLEI SA+N ++YRL T+ + ++ + ++D+ + S+ FK
Sbjct: 858 QVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVEL--SQDHFKKYLV 915
Query: 1142 TLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTE---EGLVNFSKMRMISHIIREIRQFQQT 1198
LK+ NPP VP+ G+YLT++ EEG +F + + L+NFSK R ++ I EI+Q+Q
Sbjct: 916 KLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQ 975
Query: 1199 SYRIDHQPKVAQYLLDKDLIID------EDTLYELSLKIEPR 1234
Y + +P + ++ + + + D L+ SL+IEPR
Sbjct: 976 PYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPR 1017
Score = 41.2 bits (95), Expect = 0.006
Identities = 33/131 (25%), Positives = 63/131 (48%), Gaps = 8/131 (6%)
Query: 565 TVVLLAPSRQEKAAWMSDI-----SQCVDNIRCNGLMTIVFEENSKVTVPHMIKSDARLH 619
+++ A S +EK WM+ + +D + + L+ E+ ++ P + + +
Sbjct: 521 SIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVK-- 578
Query: 620 KDDTDICFSKTLNSCK-VPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTAAVV 678
+ +I F L S +P I+ +V +L+ERLT + +F+ TFL TYR F +
Sbjct: 579 DSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQEL 638
Query: 679 LGKLSDIYKRP 689
L L + ++ P
Sbjct: 639 LSLLIERFEIP 649
>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
Length = 1333
Score = 147 bits (371), Expect = 6e-35
Identities = 96/345 (27%), Positives = 172/345 (49%), Gaps = 36/345 (10%)
Query: 917 RVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEV--------LRDPDLLPQERKAA---- 964
RVLNV RHWV H DFE + L + + V + + Q +K A
Sbjct: 688 RVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNG 747
Query: 965 -ANILRALSQDDQDDIHLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRSIPY 1023
+ + S + H+ I+ D + +L +E+A Q+TLL+ ++R++
Sbjct: 748 PGHNITFQSSPPTVEWHISRPGHIETFDLL------TLHPIEIARQLTLLESDLYRAVQP 801
Query: 1024 EEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADI 1083
E +G W K DK +P ++K +H +++ I+ ++ R + + + + +
Sbjct: 802 SELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQV 861
Query: 1084 CRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETL 1143
+ L+N+NGVLE+ SA+N S +YRL T+ ++ + K ++++ + SE +K L
Sbjct: 862 FQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL--SEDHYKKYLAKL 919
Query: 1144 KNCNPPAVPYLGMYLTDLAFIEEGTPNFTE---EGLVNFSKMRMISHIIREIRQFQQTSY 1200
++ NPP VP+ G+YLT++ EEG P + + L+NFSK R ++ I EI+Q+Q Y
Sbjct: 920 RSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPY 979
Query: 1201 RIDHQPKVAQYL---------LDKDLIIDEDTLYELSLKIEPRLP 1236
+ + + ++ ++K+ D L+ SL+IEPR P
Sbjct: 980 CLRVESDIKRFFENLNPMGNSMEKEF---TDYLFNKSLEIEPRNP 1021
Score = 44.7 bits (104), Expect = 6e-04
Identities = 47/203 (23%), Positives = 90/203 (44%), Gaps = 14/203 (6%)
Query: 492 ERQCFLFTKHFLICTRSSGGKLHLLKTGGV-LSLIDCTLIEEPDASDDDSKGSGQVFGHL 550
ER FLF +IC +S+ G+ L L + + + +D D + H
Sbjct: 458 ERHIFLFDG-LMICCKSNHGQPRLPGASNAEYRLKEKFFMRKVQINDKDDTNE---YKHA 513
Query: 551 DFKIVVEPPDAAAFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVFEENSKVTVPH 610
F+I+++ ++ F+ A S +EK WM+ + ++ + + K
Sbjct: 514 -FEIILKDENSVIFS----AKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEQMR 568
Query: 611 MIKSDA-RLHKDDTD--ICFSKTLN-SCKVPQIRYASVERLLERLTDLRFLSIDFLNTFL 666
+ +D R + D++ I F + + +P I+ +V +L+ERLT + +F+ TFL
Sbjct: 569 LPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFL 628
Query: 667 HTYRIFTTAAVVLGKLSDIYKRP 689
TYR F +L + + ++ P
Sbjct: 629 TTYRSFCKPQELLSLIIERFEIP 651
>gi|93102367 ral guanine nucleotide dissociation stimulator-like 1
[Homo sapiens]
Length = 803
Score = 130 bits (327), Expect = 8e-30
Identities = 105/382 (27%), Positives = 174/382 (45%), Gaps = 57/382 (14%)
Query: 898 NNTERTCDKEFIIRRTATNRVLNVLRHWVSKHAQDFELNNELK--MNVLNLLEEVLRDPD 955
+ ++ + + + +IR N + ++LR W+ + A+DF +L+ L ++ D
Sbjct: 163 DGSQSSSESKMVIR----NAIASILRAWLDQCAEDFREPPHFPCLQKLLDYLTRMMPGSD 218
Query: 956 LLPQERKAAANILRALSQDDQDD-------IHLKLEDIIQMTDCMKAECFESLSAMELAE 1008
P+ R A N+L + + + I LE+ ++ AE F S +AE
Sbjct: 219 --PERR--AQNLLEQFQKQEVETDNGLPNTISFSLEEEEELEGGESAE-FTCFSEDLVAE 273
Query: 1009 QITLLDHVIFRSIPYEEFLGQGWMKLDKNER---TPYIMKTSQHFNDMSNLVASQIMNYA 1065
Q+T +D +F+ + LG W + DK E P I T FN ++ V S I+
Sbjct: 274 QLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVVSTILGGK 333
Query: 1066 DVSS--RANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALM 1123
++ + RA IEKW+ +A CR L N++ + I SAL ++IYRLKKTWA V + +
Sbjct: 334 ELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVPRDRMLMF 393
Query: 1124 DKLQKTVSSEG---------------RFKNLRETLKNCNPPA----------------VP 1152
++L S +F NL ++K VP
Sbjct: 394 EELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMGVMQGTVP 453
Query: 1153 YLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQ--TSYRIDHQPKVAQ 1210
YLG +LTDL ++ ++ E GL+NF K R +I +I+ Q SY + K Q
Sbjct: 454 YLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQSACNSYCMTPDQKFIQ 513
Query: 1211 YLLDKDLIIDEDTLYELSLKIE 1232
+ + L+ +E++ Y LS +IE
Sbjct: 514 WFQRQQLLTEEES-YALSCEIE 534
Score = 32.0 bits (71), Expect = 3.8
Identities = 19/55 (34%), Positives = 30/55 (54%), Gaps = 1/55 (1%)
Query: 633 SCKVPQIRYASVERLLER-LTDLRFLSIDFLNTFLHTYRIFTTAAVVLGKLSDIY 686
+CK+ I+ ++E+L+E LT +++ FL TYR F + VL L D Y
Sbjct: 98 TCKIRTIKAGTLEKLVENLLTAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRY 152
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 129 bits (324), Expect = 2e-29
Identities = 82/230 (35%), Positives = 121/230 (52%), Gaps = 8/230 (3%)
Query: 1005 ELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNY 1064
E+AEQ+TLLD +F I E L W K E++P + + ++HFN+MS V S IM
Sbjct: 861 EIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQ 918
Query: 1065 ADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMD 1124
R + K++ + R L+N+N L I SAL+ + I RL+ W KQT +
Sbjct: 919 EKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--W---QKQTSEGLA 973
Query: 1125 KLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRM 1184
+ + S F+ R L PP +PYLG+ L DL F+ G P++ +G VNFSK
Sbjct: 974 EYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYI-DGKVNFSKRWQ 1032
Query: 1185 ISHIIREIRQFQQTSYRIDHQPKVAQYLLDKDLIIDEDTLYELSLKIEPR 1234
+I+ +R FQQ Y + + + D + E+ L+ELSLKI+PR
Sbjct: 1033 QFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPR 1082
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 129 bits (324), Expect = 2e-29
Identities = 82/230 (35%), Positives = 121/230 (52%), Gaps = 8/230 (3%)
Query: 1005 ELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNY 1064
E+AEQ+TLLD +F I E L W K E++P + + ++HFN+MS V S IM
Sbjct: 843 EIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQ 900
Query: 1065 ADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMD 1124
R + K++ + R L+N+N L I SAL+ + I RL+ W KQT +
Sbjct: 901 EKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--W---QKQTSEGLA 955
Query: 1125 KLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRM 1184
+ + S F+ R L PP +PYLG+ L DL F+ G P++ +G VNFSK
Sbjct: 956 EYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYI-DGKVNFSKRWQ 1014
Query: 1185 ISHIIREIRQFQQTSYRIDHQPKVAQYLLDKDLIIDEDTLYELSLKIEPR 1234
+I+ +R FQQ Y + + + D + E+ L+ELSLKI+PR
Sbjct: 1015 QFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPR 1064
>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
sapiens]
Length = 583
Score = 129 bits (324), Expect = 2e-29
Identities = 79/236 (33%), Positives = 129/236 (54%), Gaps = 8/236 (3%)
Query: 1005 ELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNY 1064
E A QITL+D +F++I +E GW K +K P + ++ FN +S V +I++
Sbjct: 52 EYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHA 111
Query: 1065 ADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMD 1124
+ RA + ++ A L+N + ++ + S L + I+RL KTWA +S++ K +
Sbjct: 112 QTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFE 171
Query: 1125 KLQKTVSSEGRFKNLRETLKNCN-PPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMR 1183
KL+ +S E +K LR+ + + P +PYLG+YL+DL +I+ P+ T L N +
Sbjct: 172 KLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPS-TGSILENEQRSN 230
Query: 1184 MISHIIREIRQFQQT-SYRIDHQPKVAQYLLDKDLIID-----EDTLYELSLKIEP 1233
++++I+R I QQ+ Y I P V +YL I + ED Y+LSLKIEP
Sbjct: 231 LMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEP 286
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 124 bits (311), Expect = 6e-28
Identities = 86/320 (26%), Positives = 159/320 (49%), Gaps = 11/320 (3%)
Query: 917 RVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRAL-SQDD 975
++ +R+W+ K +F L+ + ++ + EE L E+ + + ++ S D
Sbjct: 73 KICYFMRYWILKFPAEFNLD----LGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDW 128
Query: 976 QDDIHLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLD 1035
+ + + + C+ F+ L +ELAE +T L+H FR I + ++ Q ++
Sbjct: 129 MRRVTQRKKVSKKGKACL---LFDHLEPIELAEHLTFLEHKSFRRISFTDY--QSYVIHG 183
Query: 1036 KNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLE 1095
E P + ++ FN +S V +++ RA I K++ VA L N+N ++
Sbjct: 184 CLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMA 243
Query: 1096 ITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLG 1155
+ L+ S+I RLK+T + +S + +++ + VSS G + N R+ +C+ +P LG
Sbjct: 244 VVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILG 303
Query: 1156 MYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQYL-LD 1214
++L DL + P++TEE VN KM +S + E+ Q S+ ++ + L L
Sbjct: 304 VHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLS 363
Query: 1215 KDLIIDEDTLYELSLKIEPR 1234
DL ED +Y+LSL +EPR
Sbjct: 364 LDLYHTEDDIYKLSLVLEPR 383
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 124 bits (311), Expect = 6e-28
Identities = 86/320 (26%), Positives = 159/320 (49%), Gaps = 11/320 (3%)
Query: 917 RVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRAL-SQDD 975
++ +R+W+ K +F L+ + ++ + EE L E+ + + ++ S D
Sbjct: 73 KICYFMRYWILKFPAEFNLD----LGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDW 128
Query: 976 QDDIHLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLD 1035
+ + + + C+ F+ L +ELAE +T L+H FR I + ++ Q ++
Sbjct: 129 MRRVTQRKKVSKKGKACL---LFDHLEPIELAEHLTFLEHKSFRRISFTDY--QSYVIHG 183
Query: 1036 KNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLE 1095
E P + ++ FN +S V +++ RA I K++ VA L N+N ++
Sbjct: 184 CLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMA 243
Query: 1096 ITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLG 1155
+ L+ S+I RLK+T + +S + +++ + VSS G + N R+ +C+ +P LG
Sbjct: 244 VVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILG 303
Query: 1156 MYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQYL-LD 1214
++L DL + P++TEE VN KM +S + E+ Q S+ ++ + L L
Sbjct: 304 VHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLS 363
Query: 1215 KDLIIDEDTLYELSLKIEPR 1234
DL ED +Y+LSL +EPR
Sbjct: 364 LDLYHTEDDIYKLSLVLEPR 383
>gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
isoform 2 [Homo sapiens]
Length = 689
Score = 124 bits (311), Expect = 6e-28
Identities = 86/320 (26%), Positives = 159/320 (49%), Gaps = 11/320 (3%)
Query: 917 RVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRAL-SQDD 975
++ +R+W+ K +F L+ + ++ + EE L E+ + + ++ S D
Sbjct: 73 KICYFMRYWILKFPAEFNLD----LGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDW 128
Query: 976 QDDIHLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLD 1035
+ + + + C+ F+ L +ELAE +T L+H FR I + ++ Q ++
Sbjct: 129 MRRVTQRKKVSKKGKACL---LFDHLEPIELAEHLTFLEHKSFRRISFTDY--QSYVIHG 183
Query: 1036 KNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLE 1095
E P + ++ FN +S V +++ RA I K++ VA L N+N ++
Sbjct: 184 CLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMA 243
Query: 1096 ITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLG 1155
+ L+ S+I RLK+T + +S + +++ + VSS G + N R+ +C+ +P LG
Sbjct: 244 VVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILG 303
Query: 1156 MYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQYL-LD 1214
++L DL + P++TEE VN KM +S + E+ Q S+ ++ + L L
Sbjct: 304 VHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLS 363
Query: 1215 KDLIIDEDTLYELSLKIEPR 1234
DL ED +Y+LSL +EPR
Sbjct: 364 LDLYHTEDDIYKLSLVLEPR 383
>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
sapiens]
Length = 557
Score = 123 bits (309), Expect = 9e-28
Identities = 78/238 (32%), Positives = 128/238 (53%), Gaps = 11/238 (4%)
Query: 1005 ELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNY 1064
E A QITL+D +F++I EE GW K +K+ P ++ ++ FN +S V +I+
Sbjct: 53 EFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTA 112
Query: 1065 ADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMD 1124
+ RA + +V +A L+N + ++ + SAL + I+RL KTWA ++++ K +
Sbjct: 113 QTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFE 172
Query: 1125 KLQKTVSSEGRFKNLRETLKNCN-PPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMR 1183
KL +S E +K RE +++ P++PYLG+YL DL +I+ P + + N +
Sbjct: 173 KLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYP-ASGSIMENEQRSN 231
Query: 1184 MISHIIREIRQFQQTSYRIDH---QPKVAQYLLDKDLIID-----EDTLYELSLKIEP 1233
+++I+R I Q S DH P V +YL I + ED Y+LSL+IEP
Sbjct: 232 QMNNILRIIADL-QVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEP 288
>gi|239582765 ral guanine nucleotide dissociation stimulator-like 3
isoform 1 [Homo sapiens]
Length = 716
Score = 120 bits (302), Expect = 6e-27
Identities = 81/259 (31%), Positives = 128/259 (49%), Gaps = 28/259 (10%)
Query: 1002 SAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNER---TPYIMKTSQHFNDMSNLVA 1058
S E+AEQ+TL+D +F + E LG W + D+ +P + T FN ++ V
Sbjct: 247 SVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVL 306
Query: 1059 SQIMNYADVSS--RANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVS 1116
++ +++ RA +EKW+ +A CR L N++ + I SAL + IYRLK++W VS
Sbjct: 307 GSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVS 366
Query: 1117 KQTKALMDKLQKTVSSEGRFKNLRE-------------------TLKNCNPPA-VPYLGM 1156
++ + KL + S E + RE +L + PP VPYLG
Sbjct: 367 REPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGT 426
Query: 1157 YLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQ--TSYRIDHQPKVAQYLLD 1214
+LTDL ++ P+ E L+NF K R I+ I+Q Q+ SY + P + L
Sbjct: 427 FLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHA 486
Query: 1215 KDLIIDEDTLYELSLKIEP 1233
++ + +E + Y LS IEP
Sbjct: 487 QNQLTEEQS-YRLSRVIEP 504
Score = 32.3 bits (72), Expect = 2.9
Identities = 35/99 (35%), Positives = 49/99 (49%), Gaps = 18/99 (18%)
Query: 713 LVDGKSPRLCRKFSSPPPLAVSRTSSPVRARKLSLTSPLNSKIGALDLTTS--------S 764
L + +S RL R P A S SSP R++SLT L++K+ A + ++S S
Sbjct: 490 LTEEQSYRLSRVIEPP---AASCPSSPRIRRRISLTKRLSAKL-AREKSSSPSGSPGDPS 545
Query: 765 SPTTT-TQSPAASP--PPHTGQIPLDLSRGLSSPEQSPG 800
SPT++ SP+ SP PP + P SP SPG
Sbjct: 546 SPTSSLCISPSVSPGSPPSS---PRSRDAPAGSPPASPG 581
>gi|239582763 ral guanine nucleotide dissociation stimulator-like 3
isoform 2 [Homo sapiens]
Length = 710
Score = 120 bits (302), Expect = 6e-27
Identities = 81/259 (31%), Positives = 128/259 (49%), Gaps = 28/259 (10%)
Query: 1002 SAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNER---TPYIMKTSQHFNDMSNLVA 1058
S E+AEQ+TL+D +F + E LG W + D+ +P + T FN ++ V
Sbjct: 247 SVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVL 306
Query: 1059 SQIMNYADVSS--RANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVS 1116
++ +++ RA +EKW+ +A CR L N++ + I SAL + IYRLK++W VS
Sbjct: 307 GSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVS 366
Query: 1117 KQTKALMDKLQKTVSSEGRFKNLRE-------------------TLKNCNPPA-VPYLGM 1156
++ + KL + S E + RE +L + PP VPYLG
Sbjct: 367 REPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGT 426
Query: 1157 YLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQ--TSYRIDHQPKVAQYLLD 1214
+LTDL ++ P+ E L+NF K R I+ I+Q Q+ SY + P + L
Sbjct: 427 FLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHA 486
Query: 1215 KDLIIDEDTLYELSLKIEP 1233
++ + +E + Y LS IEP
Sbjct: 487 QNQLTEEQS-YRLSRVIEP 504
Score = 33.9 bits (76), Expect = 0.99
Identities = 29/92 (31%), Positives = 42/92 (45%), Gaps = 10/92 (10%)
Query: 713 LVDGKSPRLCRKFSSPPPLAVSRTSSPVRARKLSLTSPLNSKIGALDLTTSS----SPTT 768
L + +S RL R P A S SSP R++SLT L++K+ ++ S P++
Sbjct: 490 LTEEQSYRLSRVIEPP---AASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGSPGDPSS 546
Query: 769 TTQSPAASPPPHTGQIPLDLSRGLSSPEQSPG 800
T S + PP + P SP SPG
Sbjct: 547 PTSSVSPGSPPSS---PRSRDAPAGSPPASPG 575
>gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Homo
sapiens]
Length = 730
Score = 112 bits (281), Expect = 2e-24
Identities = 67/239 (28%), Positives = 118/239 (49%), Gaps = 6/239 (2%)
Query: 1001 LSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQ 1060
++ +LA ++ D +F SI +E + + + E T + Q N++ VA++
Sbjct: 494 MNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATE 553
Query: 1061 IMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTK 1120
I+ + + R ++K++ +A C+ N N I LN +++ RL +TW K+ + K
Sbjct: 554 ILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFK 613
Query: 1121 ALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFS 1180
L +L+ K R+ K PP +P++ + L D+ FI EG F + LVNF
Sbjct: 614 KLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFL-DNLVNFE 672
Query: 1181 KMRMISHIIREIRQFQQTSYRIDHQPKVAQ----YLLDKDLIIDEDTLYELSLKIEPRL 1235
K+ MI+ +R +R + + D PK Q Y+ +I + L+ELS +IEPR+
Sbjct: 673 KLHMIADTVRTLRHCRTNQFG-DLSPKEHQELKSYVNHLYVIDSQQALFELSHRIEPRV 730
>gi|24307909 ral guanine nucleotide dissociation stimulator isoform 1
[Homo sapiens]
Length = 914
Score = 107 bits (268), Expect = 5e-23
Identities = 75/259 (28%), Positives = 119/259 (45%), Gaps = 32/259 (12%)
Query: 1006 LAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNER---TPYIMKTSQHFNDMSNLVASQIM 1062
+AEQ TL+D +F+ + LG W + DK + P I T FN ++N V + +
Sbjct: 390 VAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCL 449
Query: 1063 NYADVSS--RANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTK 1120
+ RA +E W+ VA CR L N++ + I SAL ++I+RLKKTW VS+ +
Sbjct: 450 GNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSF 509
Query: 1121 ALMDKLQKTVSSEGRFKNLRETL----------KNCNPP--------------AVPYLGM 1156
+ KL + S E + RE L NP VPYLG
Sbjct: 510 RIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGT 569
Query: 1157 YLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQ--TSYRIDHQPKVAQYLLD 1214
+LTDL ++ ++ L+NF K R +I +I+ Q +Y I + +
Sbjct: 570 FLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRA 629
Query: 1215 KDLIIDEDTLYELSLKIEP 1233
+ + + ++ Y LS ++EP
Sbjct: 630 VERLSETES-YNLSCELEP 647
Score = 47.0 bits (110), Expect = 1e-04
Identities = 69/290 (23%), Positives = 113/290 (38%), Gaps = 47/290 (16%)
Query: 633 SCKVPQIRYASVERLLERLTD-LRFLSIDFLNTFLHTYRIFTTAAVVLGKLSDIYKR--P 689
+CKV ++ ++E+L+E L + + ++ FL TYR FTT VL L Y R
Sbjct: 110 TCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDA 169
Query: 690 FTSIPVRSLELFFATSQNNRGEHLVDGKSPRL-------CRKFSSPPP----------LA 732
T+ L ++ + L + S L F PP +
Sbjct: 170 LTASSRYGCILPYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQ 229
Query: 733 VSRTSSPVRAR------KLSLTSPLNSKIGALDLTTSSSPTTTTQ---SPAASPPPHTGQ 783
++ S + R +L + P+ ++ AL + PT + +PA +P P
Sbjct: 230 LNMPGSDLERRAHLLLAQLEHSEPIEAEPEALSPVPALKPTPELELALTPARAPSP---- 285
Query: 784 IPLDLSRGLSSPEQSPGTVEENVDNPRVDLCNKLKRSIQKAV-LESAPADRAGVESSPAA 842
+P +P +PG+ E P +L+++ + AV LESAPA +E +P
Sbjct: 286 VPAPAPEPEPAPTPAPGSELEVAPAP----APELQQAPEPAVGLESAPAPALELEPAPEQ 341
Query: 843 D-----TTELSPCRSPSTPRHLRYRQP----GGQTADNAHCSVSPASAFA 883
D T EL P +P + P G + + H V P A
Sbjct: 342 DPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLSEEKPHLLVFPPDLVA 391
>gi|108796058 ral guanine nucleotide dissociation stimulator isoform 2
[Homo sapiens]
Length = 859
Score = 107 bits (268), Expect = 5e-23
Identities = 75/259 (28%), Positives = 119/259 (45%), Gaps = 32/259 (12%)
Query: 1006 LAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNER---TPYIMKTSQHFNDMSNLVASQIM 1062
+AEQ TL+D +F+ + LG W + DK + P I T FN ++N V + +
Sbjct: 335 VAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCL 394
Query: 1063 NYADVSS--RANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTK 1120
+ RA +E W+ VA CR L N++ + I SAL ++I+RLKKTW VS+ +
Sbjct: 395 GNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSF 454
Query: 1121 ALMDKLQKTVSSEGRFKNLRETL----------KNCNPP--------------AVPYLGM 1156
+ KL + S E + RE L NP VPYLG
Sbjct: 455 RIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGT 514
Query: 1157 YLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQ--TSYRIDHQPKVAQYLLD 1214
+LTDL ++ ++ L+NF K R +I +I+ Q +Y I + +
Sbjct: 515 FLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRA 574
Query: 1215 KDLIIDEDTLYELSLKIEP 1233
+ + + ++ Y LS ++EP
Sbjct: 575 VERLSETES-YNLSCELEP 592
Score = 47.0 bits (110), Expect = 1e-04
Identities = 69/290 (23%), Positives = 113/290 (38%), Gaps = 47/290 (16%)
Query: 633 SCKVPQIRYASVERLLERLTD-LRFLSIDFLNTFLHTYRIFTTAAVVLGKLSDIYKR--P 689
+CKV ++ ++E+L+E L + + ++ FL TYR FTT VL L Y R
Sbjct: 55 TCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDA 114
Query: 690 FTSIPVRSLELFFATSQNNRGEHLVDGKSPRL-------CRKFSSPPP----------LA 732
T+ L ++ + L + S L F PP +
Sbjct: 115 LTASSRYGCILPYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQ 174
Query: 733 VSRTSSPVRAR------KLSLTSPLNSKIGALDLTTSSSPTTTTQ---SPAASPPPHTGQ 783
++ S + R +L + P+ ++ AL + PT + +PA +P P
Sbjct: 175 LNMPGSDLERRAHLLLAQLEHSEPIEAEPEALSPVPALKPTPELELALTPARAPSP---- 230
Query: 784 IPLDLSRGLSSPEQSPGTVEENVDNPRVDLCNKLKRSIQKAV-LESAPADRAGVESSPAA 842
+P +P +PG+ E P +L+++ + AV LESAPA +E +P
Sbjct: 231 VPAPAPEPEPAPTPAPGSELEVAPAP----APELQQAPEPAVGLESAPAPALELEPAPEQ 286
Query: 843 D-----TTELSPCRSPSTPRHLRYRQP----GGQTADNAHCSVSPASAFA 883
D T EL P +P + P G + + H V P A
Sbjct: 287 DPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLSEEKPHLLVFPPDLVA 336
>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform b
[Homo sapiens]
Length = 867
Score = 107 bits (266), Expect = 9e-23
Identities = 63/245 (25%), Positives = 121/245 (49%), Gaps = 7/245 (2%)
Query: 998 FESLSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLV 1057
FE +S+ +LA Q+T+ D +F + E + + + + + T + + FN++ V
Sbjct: 624 FELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWV 683
Query: 1058 ASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSK 1117
++I + +S R ++K++ +A C+ N N I L+ A+ RL TW K+
Sbjct: 684 VTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPS 743
Query: 1118 QTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLV 1177
+ K + + + + R T+ PP +P++ + + D+ F EG F + LV
Sbjct: 744 KFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFI-DNLV 802
Query: 1178 NFSKMRMISHIIREIRQFQQTSYRID------HQPKVAQYLLDKDLIIDEDTLYELSLKI 1231
NF KMRMI++ R +R ++ + D + V Y+ ++I ++ TL ++S ++
Sbjct: 803 NFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRL 862
Query: 1232 EPRLP 1236
EPR P
Sbjct: 863 EPRRP 867
>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform a
[Homo sapiens]
Length = 1011
Score = 107 bits (266), Expect = 9e-23
Identities = 63/245 (25%), Positives = 121/245 (49%), Gaps = 7/245 (2%)
Query: 998 FESLSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLV 1057
FE +S+ +LA Q+T+ D +F + E + + + + + T + + FN++ V
Sbjct: 768 FELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWV 827
Query: 1058 ASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSK 1117
++I + +S R ++K++ +A C+ N N I L+ A+ RL TW K+
Sbjct: 828 VTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPS 887
Query: 1118 QTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLV 1177
+ K + + + + R T+ PP +P++ + + D+ F EG F + LV
Sbjct: 888 KFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFI-DNLV 946
Query: 1178 NFSKMRMISHIIREIRQFQQTSYRID------HQPKVAQYLLDKDLIIDEDTLYELSLKI 1231
NF KMRMI++ R +R ++ + D + V Y+ ++I ++ TL ++S ++
Sbjct: 947 NFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRL 1006
Query: 1232 EPRLP 1236
EPR P
Sbjct: 1007 EPRRP 1011
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapiens]
Length = 762
Score = 103 bits (256), Expect = 1e-21
Identities = 66/238 (27%), Positives = 117/238 (49%), Gaps = 3/238 (1%)
Query: 998 FESLSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLV 1057
F+ L EL+E +T L+ FR I + ++ Q ++ + P + ++ N +S V
Sbjct: 201 FDHLEPEELSEHLTYLEFKSFRRISFSDY--QNYLVNSCVKENPTMERSIALCNGISQWV 258
Query: 1058 ASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSK 1117
+++ RA K++ VA L N+N ++ + L S+I RLK+T + V
Sbjct: 259 QLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318
Query: 1118 QTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLV 1177
+ ++ ++ + +SS + N R C +P LG++L DL + E P++ E+G V
Sbjct: 319 EINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKV 378
Query: 1178 NFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQYL-LDKDLIIDEDTLYELSLKIEPR 1234
N K+ + + I E+ Q Q+ + ++ + L L DL ED +YELS EPR
Sbjct: 379 NVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPR 436
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapiens]
Length = 797
Score = 103 bits (256), Expect = 1e-21
Identities = 66/238 (27%), Positives = 117/238 (49%), Gaps = 3/238 (1%)
Query: 998 FESLSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLV 1057
F+ L EL+E +T L+ FR I + ++ Q ++ + P + ++ N +S V
Sbjct: 201 FDHLEPEELSEHLTYLEFKSFRRISFSDY--QNYLVNSCVKENPTMERSIALCNGISQWV 258
Query: 1058 ASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSK 1117
+++ RA K++ VA L N+N ++ + L S+I RLK+T + V
Sbjct: 259 QLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318
Query: 1118 QTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLV 1177
+ ++ ++ + +SS + N R C +P LG++L DL + E P++ E+G V
Sbjct: 319 EINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKV 378
Query: 1178 NFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQYL-LDKDLIIDEDTLYELSLKIEPR 1234
N K+ + + I E+ Q Q+ + ++ + L L DL ED +YELS EPR
Sbjct: 379 NVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPR 436
>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 102 bits (254), Expect = 2e-21
Identities = 85/326 (26%), Positives = 150/326 (46%), Gaps = 20/326 (6%)
Query: 917 RVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRALSQDDQ 976
+ +++R+W+S +F+LN EL E++ LL QE + +L D
Sbjct: 74 KTCHLVRYWISAFPAEFDLNPELA-------EQIKELKALLDQEGNRRHS---SLIDIDS 123
Query: 977 DDIHLKLEDIIQMTDCMKAE-----CFESLSAMELAEQITLLDHVIFRSIPYEEFLGQGW 1031
+ + Q + + F+ L MELAE +T L++ F I ++++ +
Sbjct: 124 VPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDY--HSF 181
Query: 1032 MKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYN 1091
+ P + + FN +S V I++ RA I +V VA+ L N+N
Sbjct: 182 VTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFN 241
Query: 1092 GVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAV 1151
++ + L+ S+I RLK+T + VS +T L + L + V++ G + N R L C
Sbjct: 242 TLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRF 301
Query: 1152 PYLGMYLTDLAFIEEGTPNFTEEG--LVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVA 1209
P LG++L DL ++ P++ + +N +KM+ + I+ E+ + P +
Sbjct: 302 PILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLL 361
Query: 1210 QYL-LDKDLIIDEDTLYELSLKIEPR 1234
L + D ED LY+LSL+ EPR
Sbjct: 362 SLLTVSLDQYQTEDELYQLSLQREPR 387
>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 102 bits (254), Expect = 2e-21
Identities = 85/326 (26%), Positives = 150/326 (46%), Gaps = 20/326 (6%)
Query: 917 RVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRALSQDDQ 976
+ +++R+W+S +F+LN EL E++ LL QE + +L D
Sbjct: 74 KTCHLVRYWISAFPAEFDLNPELA-------EQIKELKALLDQEGNRRHS---SLIDIDS 123
Query: 977 DDIHLKLEDIIQMTDCMKAE-----CFESLSAMELAEQITLLDHVIFRSIPYEEFLGQGW 1031
+ + Q + + F+ L MELAE +T L++ F I ++++ +
Sbjct: 124 VPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDY--HSF 181
Query: 1032 MKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYN 1091
+ P + + FN +S V I++ RA I +V VA+ L N+N
Sbjct: 182 VTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFN 241
Query: 1092 GVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAV 1151
++ + L+ S+I RLK+T + VS +T L + L + V++ G + N R L C
Sbjct: 242 TLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRF 301
Query: 1152 PYLGMYLTDLAFIEEGTPNFTEEG--LVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVA 1209
P LG++L DL ++ P++ + +N +KM+ + I+ E+ + P +
Sbjct: 302 PILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLL 361
Query: 1210 QYL-LDKDLIIDEDTLYELSLKIEPR 1234
L + D ED LY+LSL+ EPR
Sbjct: 362 SLLTVSLDQYQTEDELYQLSLQREPR 387
>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 102 bits (254), Expect = 2e-21
Identities = 85/326 (26%), Positives = 150/326 (46%), Gaps = 20/326 (6%)
Query: 917 RVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRALSQDDQ 976
+ +++R+W+S +F+LN EL E++ LL QE + +L D
Sbjct: 74 KTCHLVRYWISAFPAEFDLNPELA-------EQIKELKALLDQEGNRRHS---SLIDIDS 123
Query: 977 DDIHLKLEDIIQMTDCMKAE-----CFESLSAMELAEQITLLDHVIFRSIPYEEFLGQGW 1031
+ + Q + + F+ L MELAE +T L++ F I ++++ +
Sbjct: 124 VPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDY--HSF 181
Query: 1032 MKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYN 1091
+ P + + FN +S V I++ RA I +V VA+ L N+N
Sbjct: 182 VTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFN 241
Query: 1092 GVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAV 1151
++ + L+ S+I RLK+T + VS +T L + L + V++ G + N R L C
Sbjct: 242 TLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRF 301
Query: 1152 PYLGMYLTDLAFIEEGTPNFTEEG--LVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVA 1209
P LG++L DL ++ P++ + +N +KM+ + I+ E+ + P +
Sbjct: 302 PILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLL 361
Query: 1210 QYL-LDKDLIIDEDTLYELSLKIEPR 1234
L + D ED LY+LSL+ EPR
Sbjct: 362 SLLTVSLDQYQTEDELYQLSLQREPR 387
>gi|4758532 ral guanine nucleotide dissociation stimulator-like 2
[Homo sapiens]
Length = 777
Score = 97.4 bits (241), Expect = 7e-20
Identities = 67/241 (27%), Positives = 106/241 (43%), Gaps = 37/241 (15%)
Query: 1003 AMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDK---NERTPYIMKTSQHFNDMSNLVAS 1059
A LAEQ+TLLD +F ++ + LG W D+ + P + T FN ++ V S
Sbjct: 244 ADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVS 303
Query: 1060 QIMNYADVSS--------------RANAIEKWVAVADICRCLHNYNGVLEITSALNRSAI 1105
++ RA +EKW+ VA+ CR L N++ V + SAL S I
Sbjct: 304 SVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPI 363
Query: 1106 YRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETL----KNCNP------------- 1148
+RL+ W + ++ + + L + S E + RE L K +P
Sbjct: 364 HRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGS 423
Query: 1149 ---PAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSYRIDHQ 1205
VPYLG +L DL ++ + + E G +NF K R ++ E+R+ Q + Q
Sbjct: 424 RGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQ 483
Query: 1206 P 1206
P
Sbjct: 484 P 484
Score = 33.5 bits (75), Expect = 1.3
Identities = 17/49 (34%), Positives = 29/49 (59%), Gaps = 2/49 (4%)
Query: 638 QIRYASVERLLERLTDLRFLSID--FLNTFLHTYRIFTTAAVVLGKLSD 684
++R ++E L+ L D R D F++ FL T+R FT+ +LG ++D
Sbjct: 91 RLRAGTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLMAD 139
>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
Length = 473
Score = 92.4 bits (228), Expect = 2e-18
Identities = 72/248 (29%), Positives = 114/248 (45%), Gaps = 26/248 (10%)
Query: 1006 LAEQITLLDHVIFRSIPYEEFLGQGWMKLDK--NERTPYIMKTS--------QHFNDMSN 1055
LA+Q+T ++ I EEF+ Q +++ D N+++ Y + + FN +S
Sbjct: 209 LAQQLTHIELERLNYIGPEEFV-QAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSY 267
Query: 1056 LVASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKV 1115
LVA++I RA IE ++ VA C + N+N ++ I S +N S + RLKKTWAKV
Sbjct: 268 LVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV 327
Query: 1116 SKQTKALMDKLQKTVSSEGRFKNLRETLKNC-----------NPPAVPYLGMYLTDLAFI 1164
A D L+ + F N R L+ +P+ + + D+ F+
Sbjct: 328 K---TAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFL 384
Query: 1165 EEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQYLLDKDLIIDEDTL 1224
EG N G VNF K ++ + E ++Q + K+ QYLL + ED L
Sbjct: 385 NEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTVP-VFSEDAL 443
Query: 1225 YELSLKIE 1232
Y S + E
Sbjct: 444 YLASYESE 451
>gi|54633319 PDZ domain-containing guanine nucleotide exchange factor
I [Homo sapiens]
Length = 1601
Score = 92.0 bits (227), Expect = 3e-18
Identities = 60/205 (29%), Positives = 104/205 (50%), Gaps = 6/205 (2%)
Query: 1001 LSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQ 1060
LS +E+A Q+++ D +FR+I E++ KL+ ++ + N + VAS+
Sbjct: 859 LSTIEVATQLSMRDFDLFRNIEPTEYIDD-LFKLNSKTGNTHLKRFEDIVNQETFWVASE 917
Query: 1061 IMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTK 1120
I+ A+ R I+ ++ +A CR N+N + I S LN +++ RL+ TW K+ + +
Sbjct: 918 ILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYE 977
Query: 1121 ALMDKLQKTVSSEGRFKNLRETL--KNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVN 1178
+ LQ R L ++ PP +P + D+ F+ EG + +GLVN
Sbjct: 978 KHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDS-KVDGLVN 1036
Query: 1179 FSKMRMISHIIREIRQFQQTSYRID 1203
F K+RMIS IR++ + TS +D
Sbjct: 1037 FEKLRMISKEIRQV--VRMTSANMD 1059
>gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [Homo
sapiens]
Length = 456
Score = 91.7 bits (226), Expect = 4e-18
Identities = 54/233 (23%), Positives = 113/233 (48%), Gaps = 6/233 (2%)
Query: 1005 ELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNY 1064
++A +T +FR + EF+ + T + Q +++++ VA++++
Sbjct: 221 DVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLC 280
Query: 1065 ADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMD 1124
RA ++K++ +A +C+ + + L+ +A+ RL+ TW K+ + K L
Sbjct: 281 EAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFR 340
Query: 1125 KLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRM 1184
K + K+ RE + PP +P++ + L DL F+ EG+ +GLVN K+
Sbjct: 341 KFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLV-DGLVNIEKLHS 399
Query: 1185 ISHIIREIRQFQQTSYRIDHQP-----KVAQYLLDKDLIIDEDTLYELSLKIE 1232
++ +R IR+++ +D + + Y+ +I +++ L+ELS K+E
Sbjct: 400 VAEKVRTIRKYRSRPLCLDMEASPNHLQTKAYVRQFQVIDNQNLLFELSYKLE 452
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,913,114
Number of Sequences: 37866
Number of extensions: 2197375
Number of successful extensions: 10544
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 116
Number of HSP's successfully gapped in prelim test: 204
Number of HSP's that attempted gapping in prelim test: 9490
Number of HSP's gapped (non-prelim): 1116
length of query: 1237
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1123
effective length of database: 13,930,794
effective search space: 15644281662
effective search space used: 15644281662
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.