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Search of human proteins with 38176283
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38176283 ankyrin repeat and SOCS box-containing protein 7
isoform 2 [Homo sapiens]
(318 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38176283 ankyrin repeat and SOCS box-containing protein 7 iso... 646 0.0
gi|30089994 ankyrin repeat and SOCS box-containing protein 7 iso... 553 e-158
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 127 2e-29
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 112 6e-25
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 112 6e-25
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 112 6e-25
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 106 3e-23
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 103 2e-22
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 103 2e-22
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 103 2e-22
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 103 2e-22
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 103 2e-22
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 103 2e-22
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 102 4e-22
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 102 6e-22
gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [H... 100 1e-21
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 100 3e-21
gi|18079216 CASK interacting protein 1 [Homo sapiens] 96 3e-20
gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1 [... 95 7e-20
gi|18254476 ankyrin repeat and SOCS box-containing protein 5 [Ho... 95 9e-20
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 94 2e-19
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 93 4e-19
gi|116325987 ankyrin repeat domain 42 [Homo sapiens] 92 5e-19
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens] 92 8e-19
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 91 1e-18
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 91 1e-18
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 91 1e-18
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 91 1e-18
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 91 1e-18
gi|34304381 inversin isoform a [Homo sapiens] 91 1e-18
>gi|38176283 ankyrin repeat and SOCS box-containing protein 7
isoform 2 [Homo sapiens]
Length = 318
Score = 646 bits (1667), Expect = 0.0
Identities = 318/318 (100%), Positives = 318/318 (100%)
Query: 1 MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKE 60
MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKE
Sbjct: 1 MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKE 60
Query: 61 RCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP 120
RCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP
Sbjct: 61 RCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP 120
Query: 121 LHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN 180
LHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN
Sbjct: 121 LHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN 180
Query: 181 GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADT 240
GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADT
Sbjct: 181 GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADT 240
Query: 241 NTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRNLQDLCRIKIRQCIGLQNLKLLDE 300
NTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRNLQDLCRIKIRQCIGLQNLKLLDE
Sbjct: 241 NTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRNLQDLCRIKIRQCIGLQNLKLLDE 300
Query: 301 LPIAKVMKDYLKHKFDDI 318
LPIAKVMKDYLKHKFDDI
Sbjct: 301 LPIAKVMKDYLKHKFDDI 318
>gi|30089994 ankyrin repeat and SOCS box-containing protein 7
isoform 1 [Homo sapiens]
Length = 274
Score = 553 bits (1426), Expect = e-158
Identities = 272/272 (100%), Positives = 272/272 (100%)
Query: 1 MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKE 60
MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKE
Sbjct: 1 MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKE 60
Query: 61 RCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP 120
RCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP
Sbjct: 61 RCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP 120
Query: 121 LHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN 180
LHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN
Sbjct: 121 LHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN 180
Query: 181 GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADT 240
GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADT
Sbjct: 181 GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADT 240
Query: 241 NTRNYEGQTPLAVSISISGSSRPCLDFLQEVT 272
NTRNYEGQTPLAVSISISGSSRPCLDFLQEVT
Sbjct: 241 NTRNYEGQTPLAVSISISGSSRPCLDFLQEVT 272
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 127 bits (318), Expect = 2e-29
Identities = 86/244 (35%), Positives = 120/244 (49%), Gaps = 10/244 (4%)
Query: 13 QEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGAD 72
Q L I A + D+ V+++L+QG SPN +G+T LH SA G E L+HGA
Sbjct: 500 QTPLHISARLGKADI--VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGAS 557
Query: 73 PTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSF 132
++ GFT LH AA +G+ +A L+L+ D A G TPLHVAAHY
Sbjct: 558 LSITTK-KGFTPLHVAAKYGKLEVANLLLQKSASPD---AAGKSGLTPLHVAAHYDNQKV 613
Query: 133 VRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDH--NANIDIQNGFLLRYAVIK 190
LLL+ A + G TPL +A + + LL++ +AN + G + +
Sbjct: 614 ALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQ 673
Query: 191 SNH-SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQT 249
H + L R A+ NL + G TPLHL+A D V A +L N GA + + G T
Sbjct: 674 EGHVDMVSLLLGRNANVNLSN-KSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYT 732
Query: 250 PLAV 253
PL V
Sbjct: 733 PLHV 736
Score = 99.4 bits (246), Expect = 4e-21
Identities = 69/231 (29%), Positives = 110/231 (47%), Gaps = 8/231 (3%)
Query: 27 VHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALH 86
+ + +L+ G S +G T +H +A G V + HGA P + + G TALH
Sbjct: 413 IKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTN-VRGETALH 471
Query: 87 YAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPL 146
AA G+A + R +++ + + AK+ D TPLH++A G+ V+ LL+ A +
Sbjct: 472 MAARSGQAEVVRYLVQDGAQ---VEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAA 528
Query: 147 SDKGTTPLQLAIIRERSSCVKILLDHNANIDI--QNGFL-LRYAVIKSNHSYCRMFLQRG 203
+ G TPL L+ LLDH A++ I + GF L A + LQ+
Sbjct: 529 TTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKS 588
Query: 204 ADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
A + + G TPLH++A D+ A +L + GA + G TPL ++
Sbjct: 589 ASPDAAG-KSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIA 638
Score = 98.6 bits (244), Expect = 6e-21
Identities = 73/259 (28%), Positives = 119/259 (45%), Gaps = 33/259 (12%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A AG V+ ++ G + N + NG+T L+ +A V+ L++GA ++
Sbjct: 111 LHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLA- 169
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDI--------------------------IN 111
GFT L A G ++ L+LE++ + + +
Sbjct: 170 TEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNAD 229
Query: 112 AKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLD 171
+S G+TPLH+AAHYG + LLL A VD + TPL +A R ++ VK+LLD
Sbjct: 230 VESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLD 289
Query: 172 HNANID--IQNGFLLRYAVIKSNH-SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVL 228
A ID ++G + +S H M L R A L + ++G +PLH++ D +
Sbjct: 290 RGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI-LSKTKNGLSPLHMATQGDHLN 348
Query: 229 CARML--YNYGADTNTRNY 245
C ++L +N D T +Y
Sbjct: 349 CVQLLLQHNVPVDDVTNDY 367
Score = 94.4 bits (233), Expect = 1e-19
Identities = 70/260 (26%), Positives = 120/260 (46%), Gaps = 13/260 (5%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G+ + V+ +L++G + + +G T LH A G E+ V + L+ A P +
Sbjct: 272 LHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAA-PILSK 330
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
G + LH A +L+L+ D + +ND T LHVAAH G ++LL
Sbjct: 331 TKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDV---TNDYLTALHVAAHCGHYKVAKVLL 387
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANID--IQNGFL-LRYAVIKSNHS 194
+ KA + + G TPL +A + R +++LL H A+I ++G + A + +
Sbjct: 388 DKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVN 447
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
+ GA N + G+T LH++A R L GA + + QTPL +S
Sbjct: 448 IVSQLMHHGASPNTTNVR-GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHIS 506
Query: 255 ISISGSSRPCLDFLQEVTRQ 274
+ + D +Q++ +Q
Sbjct: 507 ARLGKA-----DIVQQLLQQ 521
Score = 84.0 bits (206), Expect = 2e-16
Identities = 64/237 (27%), Positives = 112/237 (47%), Gaps = 12/237 (5%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G V V ++L++ + + G T LH ++ G+ V+V + +GA+ +
Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
GFT L+ AA + + +L++ + + DG+TPL VA G D V LLL
Sbjct: 138 Q-NGFTPLYMAAQENHLEVVKFLLDNGASQSLA---TEDGFTPLAVALQQGHDQVVSLLL 193
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL--DHNANIDIQNGFL-LRYAVIKSNHS 194
E D L +A ++ + +LL D+NA+++ ++GF L A N +
Sbjct: 194 EN----DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNIN 249
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
+ L R A + D TPLH+++ R + ++L + GA + + +G TPL
Sbjct: 250 VATLLLNRAAAVDFTARND-ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPL 305
Score = 76.6 bits (187), Expect = 3e-14
Identities = 52/175 (29%), Positives = 78/175 (44%), Gaps = 35/175 (20%)
Query: 33 MLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPT------------------ 74
+L+QG SP+ NG+T LH +A + + LE+GAD
Sbjct: 617 LLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGH 676
Query: 75 ---VKDLIG-----------GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP 120
V L+G G T LH AA R +A +++ D A++ G+TP
Sbjct: 677 VDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVD---AQTKMGYTP 733
Query: 121 LHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNAN 175
LHV HYG V LL+ A+V+ + G TPL A + + + +LL +NA+
Sbjct: 734 LHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNAS 788
Score = 65.5 bits (158), Expect = 6e-11
Identities = 50/177 (28%), Positives = 78/177 (44%), Gaps = 33/177 (18%)
Query: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
IN + +G LH+A+ G V LL+ +A VD + KG T L +A + ++ VK+L
Sbjct: 67 INICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVL 126
Query: 170 LDHNANIDI--QNGFLLRYAVIKSNH-SYCRMFLQRGADTNLGRLEDGQTP--------- 217
+ + AN++ QNGF Y + NH + L GA +L EDG TP
Sbjct: 127 VTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLA-TEDGFTPLAVALQQGH 185
Query: 218 --------------------LHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
LH++A +DD A +L + + + G TPL ++
Sbjct: 186 DQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIA 242
Score = 64.7 bits (156), Expect = 1e-10
Identities = 40/140 (28%), Positives = 67/140 (47%), Gaps = 4/140 (2%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G V V +L + + N + +G T LH +A + V + GA +
Sbjct: 668 VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT 727
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
+G +T LH +G +I +L+ + +NAK+ +G+TPLH AA G + +LL
Sbjct: 728 KMG-YTPLHVGCHYGNIKIVNFLLQHSAK---VNAKTKNGYTPLHQAAQQGHTHIINVLL 783
Query: 138 EFKAEVDPLSDKGTTPLQLA 157
+ A + L+ G T L +A
Sbjct: 784 QNNASPNELTVNGNTALGIA 803
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 112 bits (279), Expect = 6e-25
Identities = 79/245 (32%), Positives = 119/245 (48%), Gaps = 8/245 (3%)
Query: 13 QEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGAD 72
+E+ + A G V+ +L+ P+ NG+T LH SA G+ V LE GA
Sbjct: 475 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 534
Query: 73 PTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSF 132
++ GFT LH AA +G +A+L+L+ +D + +G TPLHVAAHY
Sbjct: 535 HSLATK-KGFTPLHVAAKYGSLDVAKLLLQRRAAAD---SAGKNGLTPLHVAAHYDNQKV 590
Query: 133 VRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNA--NIDIQNGFLLRYAVIK 190
LLLE A + G TPL +A + + LL++ A NI + G + +
Sbjct: 591 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 650
Query: 191 SNHS-YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQT 249
H+ + L +GA+ ++ + G T LHL+A D V A +L +GAD + G T
Sbjct: 651 EGHTDMVTLLLDKGANIHMST-KSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 709
Query: 250 PLAVS 254
PL V+
Sbjct: 710 PLIVA 714
Score = 107 bits (268), Expect = 1e-23
Identities = 74/242 (30%), Positives = 121/242 (50%), Gaps = 14/242 (5%)
Query: 21 AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
A + V+ +LE G + + +G+T L + +G + V + LE+ V+
Sbjct: 116 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR---- 171
Query: 81 GFTALHYAAMHGRARIARLMLESEYRSDI-----INAKSNDGWTPLHVAAHYGRDSFVRL 135
ALH AA + A L+L++++ +D+ +N + G+TPLH+AAHYG + L
Sbjct: 172 -LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATL 230
Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANID--IQNGFLLRYAVIKSNH 193
LL A VD + G TPL +A R ++ VK+LLD ID ++G + +S H
Sbjct: 231 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 290
Query: 194 -SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLA 252
+ L+RGA L R ++G +PLH++A D V C + L + A + + T L
Sbjct: 291 DQVVELLLERGAPL-LARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALH 349
Query: 253 VS 254
V+
Sbjct: 350 VA 351
Score = 104 bits (260), Expect = 9e-23
Identities = 74/240 (30%), Positives = 111/240 (46%), Gaps = 35/240 (14%)
Query: 12 LQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA 71
++ E + A AG V VR +L G + R T LH ++ GK V++ L+H A
Sbjct: 441 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA 500
Query: 72 DPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDS 131
P G+T LH +A G+ +A ++LE+ + K G+TPLHVAA YG
Sbjct: 501 HPDAA-TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK---GFTPLHVAAKYGSLD 556
Query: 132 FVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKS 191
+LLL+ +A D G TPL +A A+ D
Sbjct: 557 VAKLLLQRRAAADSAGKNGLTPLHVA----------------AHYD-------------- 586
Query: 192 NHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
N + L++GA + ++G TPLH++A ++ + A L NYGA+TN +G TPL
Sbjct: 587 NQKVALLLLEKGASPH-ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 645
Score = 98.2 bits (243), Expect = 8e-21
Identities = 69/240 (28%), Positives = 113/240 (47%), Gaps = 8/240 (3%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A +G V +LE+G R NG + LH +A CV+ L+H A P
Sbjct: 282 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA-PVDDV 340
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
+ TALH AA G R+ +L+L+ NA++ +G+TPLH+A R + LL+
Sbjct: 341 TLDYLTALHVAAHCGHYRVTKLLLDKRANP---NARALNGFTPLHIACKKNRIKVMELLV 397
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN---GFLLRYAVIKSNHS 194
++ A + +++ G TP+ +A + V +LL + A+ D+ N L A
Sbjct: 398 KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVE 457
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
R L+ GA + R + QTPLH+++ ++L + A + G TPL +S
Sbjct: 458 VVRCLLRNGALVD-ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHIS 516
Score = 94.0 bits (232), Expect = 2e-19
Identities = 72/262 (27%), Positives = 123/262 (46%), Gaps = 14/262 (5%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADP--TV 75
+ A G + + +L++ + + NG T LH +A ++ + LE GA P T
Sbjct: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
Query: 76 KDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRL 135
K+ G+T LH AA + +IA +L ++I+ + G TPLH+A+ G V L
Sbjct: 606 KN---GYTPLHIAAKKNQMQIASTLLNYGAETNIV---TKQGVTPLHLASQEGHTDMVTL 659
Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSY 195
LL+ A + + G T L LA ++ + IL H A+ D ++ ++
Sbjct: 660 LLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGN 719
Query: 196 CRM---FLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLA 252
+M L++GA+ N + ++G TPLH +A + +L +GA N G T LA
Sbjct: 720 VKMVNFLLKQGANVN-AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALA 778
Query: 253 VSISISGSSRPCLDFLQEVTRQ 274
++ + S +D L+ VT +
Sbjct: 779 IAKRLGYIS--VVDTLKVVTEE 798
Score = 89.4 bits (220), Expect = 4e-18
Identities = 73/243 (30%), Positives = 118/243 (48%), Gaps = 16/243 (6%)
Query: 21 AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA--DPTVKDL 78
A AG++ V + L+ G N + NG LH +A G V+ L G+ D K
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK- 75
Query: 79 IGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLE 138
G TALH A++ G+A + +++++ INA+S +G+TPL++AA V+ LLE
Sbjct: 76 --GNTALHIASLAGQAEVVKVLVKEGAN---INAQSQNGFTPLYMAAQENHIDVVKYLLE 130
Query: 139 FKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRM 198
A ++ G TPL +A+ + + V ILL+++ ++ L A K + +
Sbjct: 131 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLP-ALHIAARKDDTKSAAL 189
Query: 199 FLQRGADTNL-------GRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
LQ + ++ E G TPLH++A +V A +L N GA + G TPL
Sbjct: 190 LLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPL 249
Query: 252 AVS 254
V+
Sbjct: 250 HVA 252
Score = 82.0 bits (201), Expect = 6e-16
Identities = 63/245 (25%), Positives = 111/245 (45%), Gaps = 20/245 (8%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G V V+++L +G S + G T LH ++ G+ V+V ++ GA+ +
Sbjct: 47 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 106
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
GFT L+ AA + + +LE+ + + DG+TPL VA G + V +LL
Sbjct: 107 Q-NGFTPLYMAAQENHIDVVKYLLENGANQ---STATEDGFTPLAVALQQGHNQAVAILL 162
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFL-----------LRY 186
E D L +A ++ + +LL ++ N D+Q+ + L
Sbjct: 163 ----ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 218
Query: 187 AVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYE 246
A N + + L RGA + +G TPLH+++ R + ++L + G + + +
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDF-TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 277
Query: 247 GQTPL 251
G TPL
Sbjct: 278 GLTPL 282
Score = 57.0 bits (136), Expect = 2e-08
Identities = 40/146 (27%), Positives = 67/146 (45%), Gaps = 31/146 (21%)
Query: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
IN + +G LH+AA G V+ LL + VD + KG T L +A + ++ VK+L
Sbjct: 36 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 95
Query: 170 LDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLC 229
+ ANI+ Q+ ++G TPL+++A + +
Sbjct: 96 VKEGANINAQS-------------------------------QNGFTPLYMAAQENHIDV 124
Query: 230 ARMLYNYGADTNTRNYEGQTPLAVSI 255
+ L GA+ +T +G TPLAV++
Sbjct: 125 VKYLLENGANQSTATEDGFTPLAVAL 150
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 112 bits (279), Expect = 6e-25
Identities = 79/245 (32%), Positives = 119/245 (48%), Gaps = 8/245 (3%)
Query: 13 QEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGAD 72
+E+ + A G V+ +L+ P+ NG+T LH SA G+ V LE GA
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555
Query: 73 PTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSF 132
++ GFT LH AA +G +A+L+L+ +D + +G TPLHVAAHY
Sbjct: 556 HSLATK-KGFTPLHVAAKYGSLDVAKLLLQRRAAAD---SAGKNGLTPLHVAAHYDNQKV 611
Query: 133 VRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNA--NIDIQNGFLLRYAVIK 190
LLLE A + G TPL +A + + LL++ A NI + G + +
Sbjct: 612 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 671
Query: 191 SNHS-YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQT 249
H+ + L +GA+ ++ + G T LHL+A D V A +L +GAD + G T
Sbjct: 672 EGHTDMVTLLLDKGANIHMST-KSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 730
Query: 250 PLAVS 254
PL V+
Sbjct: 731 PLIVA 735
Score = 107 bits (268), Expect = 1e-23
Identities = 74/242 (30%), Positives = 121/242 (50%), Gaps = 14/242 (5%)
Query: 21 AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
A + V+ +LE G + + +G+T L + +G + V + LE+ V+
Sbjct: 137 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR---- 192
Query: 81 GFTALHYAAMHGRARIARLMLESEYRSDI-----INAKSNDGWTPLHVAAHYGRDSFVRL 135
ALH AA + A L+L++++ +D+ +N + G+TPLH+AAHYG + L
Sbjct: 193 -LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATL 251
Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANID--IQNGFLLRYAVIKSNH 193
LL A VD + G TPL +A R ++ VK+LLD ID ++G + +S H
Sbjct: 252 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 311
Query: 194 -SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLA 252
+ L+RGA L R ++G +PLH++A D V C + L + A + + T L
Sbjct: 312 DQVVELLLERGAPL-LARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALH 370
Query: 253 VS 254
V+
Sbjct: 371 VA 372
Score = 104 bits (260), Expect = 9e-23
Identities = 74/240 (30%), Positives = 111/240 (46%), Gaps = 35/240 (14%)
Query: 12 LQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA 71
++ E + A AG V VR +L G + R T LH ++ GK V++ L+H A
Sbjct: 462 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA 521
Query: 72 DPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDS 131
P G+T LH +A G+ +A ++LE+ + K G+TPLHVAA YG
Sbjct: 522 HPDAA-TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK---GFTPLHVAAKYGSLD 577
Query: 132 FVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKS 191
+LLL+ +A D G TPL +A A+ D
Sbjct: 578 VAKLLLQRRAAADSAGKNGLTPLHVA----------------AHYD-------------- 607
Query: 192 NHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
N + L++GA + ++G TPLH++A ++ + A L NYGA+TN +G TPL
Sbjct: 608 NQKVALLLLEKGASPH-ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 666
Score = 98.2 bits (243), Expect = 8e-21
Identities = 69/240 (28%), Positives = 113/240 (47%), Gaps = 8/240 (3%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A +G V +LE+G R NG + LH +A CV+ L+H A P
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA-PVDDV 361
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
+ TALH AA G R+ +L+L+ NA++ +G+TPLH+A R + LL+
Sbjct: 362 TLDYLTALHVAAHCGHYRVTKLLLDKRANP---NARALNGFTPLHIACKKNRIKVMELLV 418
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN---GFLLRYAVIKSNHS 194
++ A + +++ G TP+ +A + V +LL + A+ D+ N L A
Sbjct: 419 KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVE 478
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
R L+ GA + R + QTPLH+++ ++L + A + G TPL +S
Sbjct: 479 VVRCLLRNGALVD-ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHIS 537
Score = 94.0 bits (232), Expect = 2e-19
Identities = 72/262 (27%), Positives = 123/262 (46%), Gaps = 14/262 (5%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADP--TV 75
+ A G + + +L++ + + NG T LH +A ++ + LE GA P T
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 76 KDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRL 135
K+ G+T LH AA + +IA +L ++I+ + G TPLH+A+ G V L
Sbjct: 627 KN---GYTPLHIAAKKNQMQIASTLLNYGAETNIV---TKQGVTPLHLASQEGHTDMVTL 680
Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSY 195
LL+ A + + G T L LA ++ + IL H A+ D ++ ++
Sbjct: 681 LLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGN 740
Query: 196 CRM---FLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLA 252
+M L++GA+ N + ++G TPLH +A + +L +GA N G T LA
Sbjct: 741 VKMVNFLLKQGANVN-AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALA 799
Query: 253 VSISISGSSRPCLDFLQEVTRQ 274
++ + S +D L+ VT +
Sbjct: 800 IAKRLGYIS--VVDTLKVVTEE 819
Score = 89.4 bits (220), Expect = 4e-18
Identities = 73/243 (30%), Positives = 118/243 (48%), Gaps = 16/243 (6%)
Query: 21 AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA--DPTVKDL 78
A AG++ V + L+ G N + NG LH +A G V+ L G+ D K
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK- 96
Query: 79 IGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLE 138
G TALH A++ G+A + +++++ INA+S +G+TPL++AA V+ LLE
Sbjct: 97 --GNTALHIASLAGQAEVVKVLVKEGAN---INAQSQNGFTPLYMAAQENHIDVVKYLLE 151
Query: 139 FKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRM 198
A ++ G TPL +A+ + + V ILL+++ ++ L A K + +
Sbjct: 152 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLP-ALHIAARKDDTKSAAL 210
Query: 199 FLQRGADTNL-------GRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
LQ + ++ E G TPLH++A +V A +L N GA + G TPL
Sbjct: 211 LLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPL 270
Query: 252 AVS 254
V+
Sbjct: 271 HVA 273
Score = 82.0 bits (201), Expect = 6e-16
Identities = 63/245 (25%), Positives = 111/245 (45%), Gaps = 20/245 (8%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G V V+++L +G S + G T LH ++ G+ V+V ++ GA+ +
Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
GFT L+ AA + + +LE+ + + DG+TPL VA G + V +LL
Sbjct: 128 Q-NGFTPLYMAAQENHIDVVKYLLENGANQ---STATEDGFTPLAVALQQGHNQAVAILL 183
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFL-----------LRY 186
E D L +A ++ + +LL ++ N D+Q+ + L
Sbjct: 184 ----ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239
Query: 187 AVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYE 246
A N + + L RGA + +G TPLH+++ R + ++L + G + + +
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDF-TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 298
Query: 247 GQTPL 251
G TPL
Sbjct: 299 GLTPL 303
Score = 57.0 bits (136), Expect = 2e-08
Identities = 40/146 (27%), Positives = 67/146 (45%), Gaps = 31/146 (21%)
Query: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
IN + +G LH+AA G V+ LL + VD + KG T L +A + ++ VK+L
Sbjct: 57 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 116
Query: 170 LDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLC 229
+ ANI+ Q+ ++G TPL+++A + +
Sbjct: 117 VKEGANINAQS-------------------------------QNGFTPLYMAAQENHIDV 145
Query: 230 ARMLYNYGADTNTRNYEGQTPLAVSI 255
+ L GA+ +T +G TPLAV++
Sbjct: 146 VKYLLENGANQSTATEDGFTPLAVAL 171
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 112 bits (279), Expect = 6e-25
Identities = 79/245 (32%), Positives = 119/245 (48%), Gaps = 8/245 (3%)
Query: 13 QEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGAD 72
+E+ + A G V+ +L+ P+ NG+T LH SA G+ V LE GA
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555
Query: 73 PTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSF 132
++ GFT LH AA +G +A+L+L+ +D + +G TPLHVAAHY
Sbjct: 556 HSLATK-KGFTPLHVAAKYGSLDVAKLLLQRRAAAD---SAGKNGLTPLHVAAHYDNQKV 611
Query: 133 VRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNA--NIDIQNGFLLRYAVIK 190
LLLE A + G TPL +A + + LL++ A NI + G + +
Sbjct: 612 ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 671
Query: 191 SNHS-YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQT 249
H+ + L +GA+ ++ + G T LHL+A D V A +L +GAD + G T
Sbjct: 672 EGHTDMVTLLLDKGANIHMST-KSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 730
Query: 250 PLAVS 254
PL V+
Sbjct: 731 PLIVA 735
Score = 107 bits (268), Expect = 1e-23
Identities = 74/242 (30%), Positives = 121/242 (50%), Gaps = 14/242 (5%)
Query: 21 AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
A + V+ +LE G + + +G+T L + +G + V + LE+ V+
Sbjct: 137 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR---- 192
Query: 81 GFTALHYAAMHGRARIARLMLESEYRSDI-----INAKSNDGWTPLHVAAHYGRDSFVRL 135
ALH AA + A L+L++++ +D+ +N + G+TPLH+AAHYG + L
Sbjct: 193 -LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATL 251
Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANID--IQNGFLLRYAVIKSNH 193
LL A VD + G TPL +A R ++ VK+LLD ID ++G + +S H
Sbjct: 252 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 311
Query: 194 -SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLA 252
+ L+RGA L R ++G +PLH++A D V C + L + A + + T L
Sbjct: 312 DQVVELLLERGAPL-LARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALH 370
Query: 253 VS 254
V+
Sbjct: 371 VA 372
Score = 104 bits (260), Expect = 9e-23
Identities = 74/240 (30%), Positives = 111/240 (46%), Gaps = 35/240 (14%)
Query: 12 LQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA 71
++ E + A AG V VR +L G + R T LH ++ GK V++ L+H A
Sbjct: 462 IRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA 521
Query: 72 DPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDS 131
P G+T LH +A G+ +A ++LE+ + K G+TPLHVAA YG
Sbjct: 522 HPDAA-TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK---GFTPLHVAAKYGSLD 577
Query: 132 FVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKS 191
+LLL+ +A D G TPL +A A+ D
Sbjct: 578 VAKLLLQRRAAADSAGKNGLTPLHVA----------------AHYD-------------- 607
Query: 192 NHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
N + L++GA + ++G TPLH++A ++ + A L NYGA+TN +G TPL
Sbjct: 608 NQKVALLLLEKGASPH-ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 666
Score = 98.2 bits (243), Expect = 8e-21
Identities = 69/240 (28%), Positives = 113/240 (47%), Gaps = 8/240 (3%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A +G V +LE+G R NG + LH +A CV+ L+H A P
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA-PVDDV 361
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
+ TALH AA G R+ +L+L+ NA++ +G+TPLH+A R + LL+
Sbjct: 362 TLDYLTALHVAAHCGHYRVTKLLLDKRANP---NARALNGFTPLHIACKKNRIKVMELLV 418
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN---GFLLRYAVIKSNHS 194
++ A + +++ G TP+ +A + V +LL + A+ D+ N L A
Sbjct: 419 KYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVE 478
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
R L+ GA + R + QTPLH+++ ++L + A + G TPL +S
Sbjct: 479 VVRCLLRNGALVD-ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHIS 537
Score = 94.0 bits (232), Expect = 2e-19
Identities = 72/262 (27%), Positives = 123/262 (46%), Gaps = 14/262 (5%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADP--TV 75
+ A G + + +L++ + + NG T LH +A ++ + LE GA P T
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 76 KDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRL 135
K+ G+T LH AA + +IA +L ++I+ + G TPLH+A+ G V L
Sbjct: 627 KN---GYTPLHIAAKKNQMQIASTLLNYGAETNIV---TKQGVTPLHLASQEGHTDMVTL 680
Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSY 195
LL+ A + + G T L LA ++ + IL H A+ D ++ ++
Sbjct: 681 LLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGN 740
Query: 196 CRM---FLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLA 252
+M L++GA+ N + ++G TPLH +A + +L +GA N G T LA
Sbjct: 741 VKMVNFLLKQGANVN-AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALA 799
Query: 253 VSISISGSSRPCLDFLQEVTRQ 274
++ + S +D L+ VT +
Sbjct: 800 IAKRLGYIS--VVDTLKVVTEE 819
Score = 89.4 bits (220), Expect = 4e-18
Identities = 73/243 (30%), Positives = 118/243 (48%), Gaps = 16/243 (6%)
Query: 21 AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA--DPTVKDL 78
A AG++ V + L+ G N + NG LH +A G V+ L G+ D K
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK- 96
Query: 79 IGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLE 138
G TALH A++ G+A + +++++ INA+S +G+TPL++AA V+ LLE
Sbjct: 97 --GNTALHIASLAGQAEVVKVLVKEGAN---INAQSQNGFTPLYMAAQENHIDVVKYLLE 151
Query: 139 FKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRM 198
A ++ G TPL +A+ + + V ILL+++ ++ L A K + +
Sbjct: 152 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLP-ALHIAARKDDTKSAAL 210
Query: 199 FLQRGADTNL-------GRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
LQ + ++ E G TPLH++A +V A +L N GA + G TPL
Sbjct: 211 LLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPL 270
Query: 252 AVS 254
V+
Sbjct: 271 HVA 273
Score = 82.0 bits (201), Expect = 6e-16
Identities = 63/245 (25%), Positives = 111/245 (45%), Gaps = 20/245 (8%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G V V+++L +G S + G T LH ++ G+ V+V ++ GA+ +
Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
GFT L+ AA + + +LE+ + + DG+TPL VA G + V +LL
Sbjct: 128 Q-NGFTPLYMAAQENHIDVVKYLLENGANQ---STATEDGFTPLAVALQQGHNQAVAILL 183
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFL-----------LRY 186
E D L +A ++ + +LL ++ N D+Q+ + L
Sbjct: 184 ----ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHI 239
Query: 187 AVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYE 246
A N + + L RGA + +G TPLH+++ R + ++L + G + + +
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDF-TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 298
Query: 247 GQTPL 251
G TPL
Sbjct: 299 GLTPL 303
Score = 57.0 bits (136), Expect = 2e-08
Identities = 40/146 (27%), Positives = 67/146 (45%), Gaps = 31/146 (21%)
Query: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
IN + +G LH+AA G V+ LL + VD + KG T L +A + ++ VK+L
Sbjct: 57 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 116
Query: 170 LDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLC 229
+ ANI+ Q+ ++G TPL+++A + +
Sbjct: 117 VKEGANINAQS-------------------------------QNGFTPLYMAAQENHIDV 145
Query: 230 ARMLYNYGADTNTRNYEGQTPLAVSI 255
+ L GA+ +T +G TPLAV++
Sbjct: 146 VKYLLENGANQSTATEDGFTPLAVAL 171
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 106 bits (264), Expect = 3e-23
Identities = 79/245 (32%), Positives = 120/245 (48%), Gaps = 10/245 (4%)
Query: 21 AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
A+ +GD + K+L+ D+ G +LLH + G+E C + L + A+P + + G
Sbjct: 413 AIVSGDTSKLMKILQPQDVDLALDS-GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRG 471
Query: 81 GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
T LH A + L+L R +NAK D WT LH AA G +S RLLLE
Sbjct: 472 S-TPLHMAVERRVRGVVELLLA---RKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKN 527
Query: 141 AEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN---GFLLRYAVIKSNHSYCR 197
A V+ + +G TP+ +A + + V+ILL ++ +Q L YA + + +
Sbjct: 528 ASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVK 587
Query: 198 MFL-QRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSIS 256
+ Q G N L DG+TPLHL+A R AR+L + +D N + QTPL V+
Sbjct: 588 LLAKQPGVSVNAQTL-DGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAE 646
Query: 257 ISGSS 261
+S
Sbjct: 647 TGHTS 651
Score = 95.1 bits (235), Expect = 7e-20
Identities = 72/226 (31%), Positives = 103/226 (45%), Gaps = 9/226 (3%)
Query: 30 VRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAA 89
V +L + S N +D + WT LHF+A G E R+ LE A D G T +H A
Sbjct: 487 VELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGR-TPMHVAC 545
Query: 90 MHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKA-EVDPLSD 148
HG+ I R++L R ++ + D W PLH AA G V+LL + V+ +
Sbjct: 546 QHGQENIVRILLR---RGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTL 602
Query: 149 KGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFL---LRYAVIKSNHSYCRMFLQRGAD 205
G TPL LA R +IL+D +++++ + L A + S R+ L RGA
Sbjct: 603 DGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAG 662
Query: 206 TNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
DG T LHL+A + ++L AD R QT L
Sbjct: 663 KE-AMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTAL 707
Score = 87.0 bits (214), Expect = 2e-17
Identities = 63/205 (30%), Positives = 103/205 (50%), Gaps = 7/205 (3%)
Query: 21 AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
A GD + R +LE+ S N D G T +H + G+E VR+ L G D +++
Sbjct: 511 AAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGK-D 569
Query: 81 GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
+ LHYAA G I +L+ + S +NA++ DG TPLH+AA G R+L++
Sbjct: 570 AWLPLHYAAWQGHLPIVKLLAKQPGVS--VNAQTLDGRTPLHLAAQRGHYRVARILIDLC 627
Query: 141 AEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANID--IQNGFLLRYAVIKSNH-SYCR 197
++V+ S TPL +A +S ++LL A + +G+ + ++ H + +
Sbjct: 628 SDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVK 687
Query: 198 MFLQRGADTNLGRLEDGQTPLHLSA 222
+ ++ AD L R QT LHL+A
Sbjct: 688 LLVEEKADV-LARGPLNQTALHLAA 711
Score = 74.3 bits (181), Expect = 1e-13
Identities = 66/233 (28%), Positives = 109/233 (46%), Gaps = 6/233 (2%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G + VR +L +G + + + W LH++A +G V++ +
Sbjct: 541 MHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQ 600
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
+ G T LH AA G R+AR+++ + SD +N S TPLHVAA G S RLLL
Sbjct: 601 TLDGRTPLHLAAQRGHYRVARILI--DLCSD-VNVCSLLAQTPLHVAAETGHTSTARLLL 657
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAV-IKSNHSYC 196
A + ++ G T L LA + VK+L++ A++ + G L + A+ + + H +
Sbjct: 658 HRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADV-LARGPLNQTALHLAAAHGHS 716
Query: 197 RMFLQR-GADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQ 248
+ + AD E G + LHL+A L +GA N ++ + Q
Sbjct: 717 EVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQ 769
Score = 56.2 bits (134), Expect = 4e-08
Identities = 37/133 (27%), Positives = 60/133 (45%), Gaps = 5/133 (3%)
Query: 12 LQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA 71
L + + A G T R +L +G ++G+T LH +A G V++ +E A
Sbjct: 635 LLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKA 694
Query: 72 DPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDS 131
D + + TALH AA HG + + +E +D+I+ G + LH+AA
Sbjct: 695 DVLARGPLNQ-TALHLAAAHGHSEV----VEELVSADVIDLFDEQGLSALHLAAQGRHAQ 749
Query: 132 FVRLLLEFKAEVD 144
V LL A ++
Sbjct: 750 TVETLLRHGAHIN 762
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 103 bits (257), Expect = 2e-22
Identities = 75/271 (27%), Positives = 128/271 (47%), Gaps = 36/271 (13%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ AVA+ V+ +++ N RD N T LH +AA +C V + + V D
Sbjct: 53 LHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSD 112
Query: 78 LIGGFTALHYAAMHGRARIARLMLE------------------SEYRSDI---------- 109
GG TALH+AA++G + L+L + Y +
Sbjct: 113 R-GGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHG 171
Query: 110 --INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVK 167
+ K G+TPLH AA G+ + V+ LL E+D ++ G T L +A + + V
Sbjct: 172 AEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVN 231
Query: 168 ILLDHNANID--IQNGFL-LRYAVIKSNHSYC-RMFLQRGADTNLGRLEDGQTPLHLSAL 223
L+D+ AN++ NGF L +A ++ + C + + GAD N+ + +DG++PLH++A+
Sbjct: 232 ELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNI-QSKDGKSPLHMTAV 290
Query: 224 RDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
++ L G + + + +G TPL V+
Sbjct: 291 HGRFTRSQTLIQNGGEIDCVDKDGNTPLHVA 321
Score = 91.7 bits (226), Expect = 8e-19
Identities = 68/231 (29%), Positives = 108/231 (46%), Gaps = 9/231 (3%)
Query: 25 GDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKER-CVRVFLEHGADPTVKDLIGGFT 83
G V ++++ G + N + NG+T LHF+AA C+ + + +GAD ++ G +
Sbjct: 225 GQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSK-DGKS 283
Query: 84 ALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEV 143
LH A+HGR ++ ++++ D ++ DG TPLHVAA YG + + L A+
Sbjct: 284 PLHMTAVHGRFTRSQTLIQNGGEIDCVD---KDGNTPLHVAARYGHELLINTLRTSGADT 340
Query: 144 DPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGF---LLRYAVIKSNHSYCRMFL 200
PL LA + S C + LL ID + F L A N ++
Sbjct: 341 AKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQ 400
Query: 201 QRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
GAD + + + G+TPLH +A C L GA+ N + G+T L
Sbjct: 401 SSGADFH-KKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTAL 450
Score = 88.6 bits (218), Expect = 7e-18
Identities = 70/237 (29%), Positives = 101/237 (42%), Gaps = 31/237 (13%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ AVA G + V +LE+ + + D G T LH G E CV++ LE KD
Sbjct: 649 LMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKD 708
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
G T LHYAA G A +L+ + K N G+TPLH A + G ++ + +LL
Sbjct: 709 SRGR-TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLL 767
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCR 197
E K TPL AII + +C +LL I S+ CR
Sbjct: 768 EQKC-FRKFIGNPFTPLHCAIINDHGNCASLLL----------------GAIDSSIVSCR 810
Query: 198 MFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
+ G+TPL +A D V C ++L + A N + G+T L ++
Sbjct: 811 D-------------DKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMA 854
Score = 87.8 bits (216), Expect = 1e-17
Identities = 61/196 (31%), Positives = 89/196 (45%), Gaps = 5/196 (2%)
Query: 43 RDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLE 102
RD G T L +A +G CV + GA VKD + T LH + ++G RL+LE
Sbjct: 571 RDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLE 630
Query: 103 SEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRER 162
+ ++ K G TPL +A YG V LLLE +A VD + G T L I+
Sbjct: 631 IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGH 690
Query: 163 SSCVKILLDHNANI---DIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLED--GQTP 217
CV++LL+ +I D + L YA + + ++ LQ +D G TP
Sbjct: 691 EECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTP 750
Query: 218 LHLSALRDDVLCARML 233
LH + + C +L
Sbjct: 751 LHWACYNGNENCIEVL 766
Score = 85.9 bits (211), Expect = 4e-17
Identities = 75/299 (25%), Positives = 132/299 (44%), Gaps = 45/299 (15%)
Query: 6 CRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKER---- 61
C R P + A A H + ++ G + N D G T LH++AA +R
Sbjct: 412 CGRTP-------LHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTI 464
Query: 62 ------------------------CVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIA 97
C+ L++ A+P+++D G+ ++HYAA +G +
Sbjct: 465 LGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDK-EGYNSIHYAAAYGHRQCL 523
Query: 98 RLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLA 157
L+LE S + S +PLH+AA+ G + +LL+ ++D +KG T L LA
Sbjct: 524 ELLLERT-NSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLA 582
Query: 158 IIRERSSCVKILLDHNANIDIQNGFLLR---YAVIKSNHSYC-RMFLQRGADTNLGRLED 213
+ + CV+ L++ A+I +++ R +A + + H+ C R+ L+ + ++D
Sbjct: 583 AFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKD 642
Query: 214 --GQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQE 270
GQTPL L+ + +L A+ +T + G T A+ I C+ L E
Sbjct: 643 AKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCT--ALHRGIMTGHEECVQMLLE 699
Score = 78.6 bits (192), Expect = 7e-15
Identities = 71/272 (26%), Positives = 115/272 (42%), Gaps = 34/272 (12%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ AA A G+V ++ + G + +D G T LH++AA C+ + GA+ D
Sbjct: 384 LHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETD 443
Query: 78 LIGGFTALHYAAMHG------------------------RARIARLMLESEYRSDI-INA 112
G TALHYAA + + A L LE ++D +
Sbjct: 444 -DWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSI 502
Query: 113 KSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTT--PLQLAIIRERSSCVKILL 170
+ +G+ +H AA YG + LLLE SD G T PL LA +++LL
Sbjct: 503 RDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLL 562
Query: 171 DHNANIDIQN---GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDV 227
++DI++ L A K + + GA + +TPLH S +
Sbjct: 563 QSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHT 622
Query: 228 LCARMLYNYGAD---TNTRNYEGQTPLAVSIS 256
LC R+L + + ++ +GQTPL ++++
Sbjct: 623 LCLRLLLEIADNPEAVDVKDAKGQTPLMLAVA 654
Score = 69.3 bits (168), Expect = 4e-12
Identities = 48/177 (27%), Positives = 87/177 (49%), Gaps = 7/177 (3%)
Query: 83 TALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAE 142
T LH AA G A I L++ S R +NAK N TPLH A + V++L++ A+
Sbjct: 18 TPLHVAAFLGDAEIIELLILSGAR---VNAKDNMWLTPLHRAVASRSEEAVQVLIKHSAD 74
Query: 143 VDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNG---FLLRYAVIKSNHSYCRMF 199
V+ TPL +A + C ++++ +++++ + L +A + + +
Sbjct: 75 VNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLL 134
Query: 200 LQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSIS 256
L +GA+ N +D + LH +A + +L N+GA+ ++ +G TPL + S
Sbjct: 135 LAKGANINAFDKKDRRA-LHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAAS 190
Score = 63.9 bits (154), Expect = 2e-10
Identities = 54/196 (27%), Positives = 91/196 (46%), Gaps = 12/196 (6%)
Query: 21 AVAAGDVHTVRKMLEQGYSPNG---RDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
A A G + ++L+ S +D G+T LH++ G E C+ V LE +
Sbjct: 718 AAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKC---FRK 774
Query: 78 LIGG-FTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLL 136
IG FT LH A ++ A L+L + S I++ + + G TPL AA ++LL
Sbjct: 775 FIGNPFTPLHCAIINDHGNCASLLLGA-IDSSIVSCRDDKGRTPLRAAAFADHVECLQLL 833
Query: 137 LEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDH-NANIDIQNGFL---LRYAVIKSN 192
L A V+ + + G T L +A ++ V IL++ A++ +++ L L A K +
Sbjct: 834 LRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGH 893
Query: 193 HSYCRMFLQRGADTNL 208
+ L + D +L
Sbjct: 894 EKCALLILDKIQDESL 909
Score = 40.0 bits (92), Expect = 0.003
Identities = 31/99 (31%), Positives = 46/99 (46%), Gaps = 2/99 (2%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHG-ADPTVK 76
++AA A V ++ +L N D +G T L +A G+ V + + AD TVK
Sbjct: 818 LRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVK 877
Query: 77 DLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSN 115
D T LH A G + A L+L+ +IN K+N
Sbjct: 878 DKDLN-TPLHLACSKGHEKCALLILDKIQDESLINEKNN 915
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 103 bits (257), Expect = 2e-22
Identities = 75/229 (32%), Positives = 113/229 (49%), Gaps = 8/229 (3%)
Query: 26 DVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTAL 85
+++ + +L +G S N NG T LH ++ RG VR+ L+ GA K T L
Sbjct: 251 NLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPL 309
Query: 86 HYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDP 145
H AA +G RI+ ++L+ I AK+ +G +P+H+AA VRLLL++ AE+D
Sbjct: 310 HCAARNGHVRISEILLD---HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 366
Query: 146 LSDKGTTPLQLAIIRERSSCVKILLDHNA--NIDIQNGFLLRYAVIKSNH-SYCRMFLQR 202
++ TPL +A K+LLD A N NGF + K NH + L+
Sbjct: 367 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 426
Query: 203 GADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
GA + E G TPLH+++ + + L GA N N + +TPL
Sbjct: 427 GASID-AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 474
Score = 100 bits (250), Expect = 1e-21
Identities = 76/244 (31%), Positives = 111/244 (45%), Gaps = 8/244 (3%)
Query: 14 EELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADP 73
++ + A G + V+ +LE +PN G T LH +A G V LE A
Sbjct: 503 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 562
Query: 74 TVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFV 133
GFT LH AA +G+ R+A L+LE + NA +G TPLHVA H+ V
Sbjct: 563 ACMTK-KGFTPLHVAAKYGKVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIV 618
Query: 134 RLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDH--NANIDIQNGFLLRYAVIKS 191
+LLL + G TPL +A + + + LL + +AN + G + +
Sbjct: 619 KLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 678
Query: 192 NHS-YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTP 250
H+ + L + A+ NLG + G TPLHL A V A +L +G + G TP
Sbjct: 679 GHAEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 737
Query: 251 LAVS 254
L V+
Sbjct: 738 LHVA 741
Score = 96.3 bits (238), Expect = 3e-20
Identities = 69/237 (29%), Positives = 115/237 (48%), Gaps = 12/237 (5%)
Query: 21 AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
A + V+ +LE G + N +G+T L + +G E V + +G V+
Sbjct: 151 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR---- 206
Query: 81 GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
ALH AA + R A ++L+++ D++ S G+TPLH+AAHY + +LLL
Sbjct: 207 -LPALHIAARNDDTRTAAVLLQNDPNPDVL---SKTGFTPLHIAAHYENLNVAQLLLNRG 262
Query: 141 AEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCR--- 197
A V+ G TPL +A R V++LLD A I+ + L + + + R
Sbjct: 263 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 322
Query: 198 MFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
+ L GA + ++G +P+H++A D + C R+L Y A+ + + TPL V+
Sbjct: 323 ILLDHGAPIQ-AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 378
Score = 93.6 bits (231), Expect = 2e-19
Identities = 69/242 (28%), Positives = 110/242 (45%), Gaps = 10/242 (4%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA--DPTV 75
+ A G + +L++G PN R NG+T LH + + R + + L+ GA D
Sbjct: 375 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 434
Query: 76 KDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRL 135
+ G T LH A+ G I + +L+ ++ N K TPLH+AA G +
Sbjct: 435 E---SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE---TPLHMAARAGHTEVAKY 488
Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFLLRYAVIKSNH 193
LL+ KA+V+ + TPL A ++ VK+LL++NAN ++ G + + H
Sbjct: 489 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 548
Query: 194 SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAV 253
+ L + + G TPLH++A V A +L A N G TPL V
Sbjct: 549 VETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 608
Query: 254 SI 255
++
Sbjct: 609 AV 610
Score = 93.6 bits (231), Expect = 2e-19
Identities = 78/270 (28%), Positives = 123/270 (45%), Gaps = 41/270 (15%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A V + +L+ G S + +G T LH ++ G V+ L+ GA P V +
Sbjct: 408 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 467
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
+ T LH AA G +A+ +L+++ + +NAK+ D TPLH AA G + V+LLL
Sbjct: 468 -VKVETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARIGHTNMVKLLL 523
Query: 138 EFKAEVDPLSDKGTTPLQ-----------LAIIRERSS---------------------- 164
E A + + G TPL LA++ + +S
Sbjct: 524 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 583
Query: 165 CVKILLDHNA--NIDIQNGFL-LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLS 221
++LL+ +A N +NG L AV +N ++ L RG + +G TPLH++
Sbjct: 584 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SPAWNGYTPLHIA 642
Query: 222 ALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
A ++ V AR L YG N + +G TPL
Sbjct: 643 AKQNQVEVARSLLQYGGSANAESVQGVTPL 672
Score = 92.8 bits (229), Expect = 4e-19
Identities = 72/240 (30%), Positives = 103/240 (42%), Gaps = 8/240 (3%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G V +LE+ PN NG T LH + V++ L G P
Sbjct: 573 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SP 631
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
G+T LH AA + +AR +L+ NA+S G TPLH+AA G V LLL
Sbjct: 632 AWNGYTPLHIAAKQNQVEVARSLLQY---GGSANAESVQGVTPLHLAAQEGHAEMVALLL 688
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFL-LRYAVIKSNHS 194
+A + + G TPL L +L+ H +D G+ L A N
Sbjct: 689 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 748
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
+ LQ AD N + + G +PLH +A + +L GA N + +G TPLA++
Sbjct: 749 LVKFLLQHQADVN-AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 807
Score = 90.5 bits (223), Expect = 2e-18
Identities = 69/237 (29%), Positives = 107/237 (45%), Gaps = 8/237 (3%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G V TV +LE+ S G+T LH +A GK R + LE A P
Sbjct: 540 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 599
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
G T LH A H I +L+L R ++ + +G+TPLH+AA + R LL
Sbjct: 600 K-NGLTPLHVAVHHNNLDIVKLLLP---RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 655
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFLLRYAVIKSNH-S 194
++ + S +G TPL LA + V +LL AN ++ N G + V + H
Sbjct: 656 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 715
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
+ ++ G + G TPLH+++ ++ + L + AD N + G +PL
Sbjct: 716 VADVLIKHGVMVD-ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPL 771
Score = 88.6 bits (218), Expect = 7e-18
Identities = 69/207 (33%), Positives = 102/207 (49%), Gaps = 8/207 (3%)
Query: 51 LHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDII 110
LH +A R V L++ +P V G FT LH AA + +A+L+L R +
Sbjct: 210 LHIAARNDDTRTAAVLLQNDPNPDVLSKTG-FTPLHIAAHYENLNVAQLLLN---RGASV 265
Query: 111 NAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL 170
N +G TPLH+A+ G VRLLL+ A+++ + TPL A +ILL
Sbjct: 266 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 325
Query: 171 DHNANIDIQ--NGFLLRYAVIKSNHSYC-RMFLQRGADTNLGRLEDGQTPLHLSALRDDV 227
DH A I + NG + + +H C R+ LQ A+ + L D TPLH++A
Sbjct: 326 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL-DHLTPLHVAAHCGHH 384
Query: 228 LCARMLYNYGADTNTRNYEGQTPLAVS 254
A++L + GA N+R G TPL ++
Sbjct: 385 RVAKVLLDKGAKPNSRALNGFTPLHIA 411
Score = 84.7 bits (208), Expect = 1e-16
Identities = 67/238 (28%), Positives = 112/238 (47%), Gaps = 14/238 (5%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G V V ++L + G T LH +A G++ VR + +GA+ +
Sbjct: 82 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 141
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
GFT L+ AA + + +LE+ N + DG+TPL VA G ++ V L+
Sbjct: 142 Q-KGFTPLYMAAQENHLEVVKFLLENGANQ---NVATEDGFTPLAVALQQGHENVVAHLI 197
Query: 138 EFKAEVDPLSDKGTTP-LQLAIIRERSSCVKILLDHNANIDI--QNGFL-LRYAVIKSNH 193
+ + K P L +A + + +LL ++ N D+ + GF L A N
Sbjct: 198 NYGTK-----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 252
Query: 194 SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
+ ++ L RGA N ++G TPLH+++ R +V+ R+L + GA T+ + TPL
Sbjct: 253 NVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 309
Score = 71.2 bits (173), Expect = 1e-12
Identities = 57/205 (27%), Positives = 87/205 (42%), Gaps = 34/205 (16%)
Query: 81 GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
G LH A+ G ++ +L E I+ + G T LH+AA G+D VR L+ +
Sbjct: 78 GLNGLHLASKEGHVKMVVELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYG 134
Query: 141 AEVDPLSDKGTTPLQLAIIRERSSCVKILLDH--NANIDIQNGFLLRYAVIKSNHSYCRM 198
A V+ S KG TPL +A VK LL++ N N+ ++GF ++ H
Sbjct: 135 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVA 194
Query: 199 FL-----------------QRGADTNLGRL------------EDGQTPLHLSALRDDVLC 229
L R DT + + G TPLH++A +++
Sbjct: 195 HLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNV 254
Query: 230 ARMLYNYGADTNTRNYEGQTPLAVS 254
A++L N GA N G TPL ++
Sbjct: 255 AQLLLNRGASVNFTPQNGITPLHIA 279
Score = 56.6 bits (135), Expect = 3e-08
Identities = 40/137 (29%), Positives = 66/137 (48%), Gaps = 4/137 (2%)
Query: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
IN + +G LH+A+ G V LL + ++ + KG T L +A + + V+ L
Sbjct: 71 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 130
Query: 170 LDHNANIDIQN--GFLLRYAVIKSNH-SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDD 226
+++ AN++ Q+ GF Y + NH + L+ GA+ N+ EDG TPL ++ +
Sbjct: 131 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVA-TEDGFTPLAVALQQGH 189
Query: 227 VLCARMLYNYGADTNTR 243
L NYG R
Sbjct: 190 ENVVAHLINYGTKGKVR 206
Score = 49.7 bits (117), Expect = 3e-06
Identities = 34/112 (30%), Positives = 53/112 (47%), Gaps = 4/112 (3%)
Query: 25 GDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTA 84
G V +++ G + G+T LH ++ G + V+ L+H AD K +G ++
Sbjct: 712 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG-YSP 770
Query: 85 LHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLL 136
LH AA G I L+L++ N S+DG TPL +A G S +L
Sbjct: 771 LHQAAQQGHTDIVTLLLKNGASP---NEVSSDGTTPLAIAKRLGYISVTDVL 819
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 103 bits (257), Expect = 2e-22
Identities = 75/229 (32%), Positives = 113/229 (49%), Gaps = 8/229 (3%)
Query: 26 DVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTAL 85
+++ + +L +G S N NG T LH ++ RG VR+ L+ GA K T L
Sbjct: 218 NLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPL 276
Query: 86 HYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDP 145
H AA +G RI+ ++L+ I AK+ +G +P+H+AA VRLLL++ AE+D
Sbjct: 277 HCAARNGHVRISEILLD---HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 146 LSDKGTTPLQLAIIRERSSCVKILLDHNA--NIDIQNGFLLRYAVIKSNH-SYCRMFLQR 202
++ TPL +A K+LLD A N NGF + K NH + L+
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 203 GADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
GA + E G TPLH+++ + + L GA N N + +TPL
Sbjct: 394 GASID-AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Score = 100 bits (250), Expect = 1e-21
Identities = 76/244 (31%), Positives = 111/244 (45%), Gaps = 8/244 (3%)
Query: 14 EELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADP 73
++ + A G + V+ +LE +PN G T LH +A G V LE A
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529
Query: 74 TVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFV 133
GFT LH AA +G+ R+A L+LE + NA +G TPLHVA H+ V
Sbjct: 530 ACMTK-KGFTPLHVAAKYGKVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIV 585
Query: 134 RLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDH--NANIDIQNGFLLRYAVIKS 191
+LLL + G TPL +A + + + LL + +AN + G + +
Sbjct: 586 KLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 645
Query: 192 NHS-YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTP 250
H+ + L + A+ NLG + G TPLHL A V A +L +G + G TP
Sbjct: 646 GHAEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 704
Query: 251 LAVS 254
L V+
Sbjct: 705 LHVA 708
Score = 96.3 bits (238), Expect = 3e-20
Identities = 69/237 (29%), Positives = 115/237 (48%), Gaps = 12/237 (5%)
Query: 21 AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
A + V+ +LE G + N +G+T L + +G E V + +G V+
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR---- 173
Query: 81 GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
ALH AA + R A ++L+++ D++ S G+TPLH+AAHY + +LLL
Sbjct: 174 -LPALHIAARNDDTRTAAVLLQNDPNPDVL---SKTGFTPLHIAAHYENLNVAQLLLNRG 229
Query: 141 AEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCR--- 197
A V+ G TPL +A R V++LLD A I+ + L + + + R
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 198 MFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
+ L GA + ++G +P+H++A D + C R+L Y A+ + + TPL V+
Sbjct: 290 ILLDHGAPIQ-AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345
Score = 93.6 bits (231), Expect = 2e-19
Identities = 69/242 (28%), Positives = 110/242 (45%), Gaps = 10/242 (4%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA--DPTV 75
+ A G + +L++G PN R NG+T LH + + R + + L+ GA D
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 76 KDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRL 135
+ G T LH A+ G I + +L+ ++ N K TPLH+AA G +
Sbjct: 402 E---SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE---TPLHMAARAGHTEVAKY 455
Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFLLRYAVIKSNH 193
LL+ KA+V+ + TPL A ++ VK+LL++NAN ++ G + + H
Sbjct: 456 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Query: 194 SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAV 253
+ L + + G TPLH++A V A +L A N G TPL V
Sbjct: 516 VETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575
Query: 254 SI 255
++
Sbjct: 576 AV 577
Score = 93.6 bits (231), Expect = 2e-19
Identities = 78/270 (28%), Positives = 123/270 (45%), Gaps = 41/270 (15%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A V + +L+ G S + +G T LH ++ G V+ L+ GA P V +
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
+ T LH AA G +A+ +L+++ + +NAK+ D TPLH AA G + V+LLL
Sbjct: 435 -VKVETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARIGHTNMVKLLL 490
Query: 138 EFKAEVDPLSDKGTTPLQ-----------LAIIRERSS---------------------- 164
E A + + G TPL LA++ + +S
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550
Query: 165 CVKILLDHNA--NIDIQNGFL-LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLS 221
++LL+ +A N +NG L AV +N ++ L RG + +G TPLH++
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SPAWNGYTPLHIA 609
Query: 222 ALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
A ++ V AR L YG N + +G TPL
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPL 639
Score = 92.8 bits (229), Expect = 4e-19
Identities = 72/240 (30%), Positives = 103/240 (42%), Gaps = 8/240 (3%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G V +LE+ PN NG T LH + V++ L G P
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SP 598
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
G+T LH AA + +AR +L+ NA+S G TPLH+AA G V LLL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQY---GGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFL-LRYAVIKSNHS 194
+A + + G TPL L +L+ H +D G+ L A N
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
+ LQ AD N + + G +PLH +A + +L GA N + +G TPLA++
Sbjct: 716 LVKFLLQHQADVN-AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 90.5 bits (223), Expect = 2e-18
Identities = 69/237 (29%), Positives = 107/237 (45%), Gaps = 8/237 (3%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G V TV +LE+ S G+T LH +A GK R + LE A P
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
G T LH A H I +L+L R ++ + +G+TPLH+AA + R LL
Sbjct: 567 K-NGLTPLHVAVHHNNLDIVKLLLP---RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFLLRYAVIKSNH-S 194
++ + S +G TPL LA + V +LL AN ++ N G + V + H
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
+ ++ G + G TPLH+++ ++ + L + AD N + G +PL
Sbjct: 683 VADVLIKHGVMVD-ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPL 738
Score = 88.6 bits (218), Expect = 7e-18
Identities = 69/207 (33%), Positives = 102/207 (49%), Gaps = 8/207 (3%)
Query: 51 LHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDII 110
LH +A R V L++ +P V G FT LH AA + +A+L+L R +
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTG-FTPLHIAAHYENLNVAQLLLN---RGASV 232
Query: 111 NAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL 170
N +G TPLH+A+ G VRLLL+ A+++ + TPL A +ILL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 171 DHNANIDIQ--NGFLLRYAVIKSNHSYC-RMFLQRGADTNLGRLEDGQTPLHLSALRDDV 227
DH A I + NG + + +H C R+ LQ A+ + L D TPLH++A
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL-DHLTPLHVAAHCGHH 351
Query: 228 LCARMLYNYGADTNTRNYEGQTPLAVS 254
A++L + GA N+R G TPL ++
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIA 378
Score = 84.7 bits (208), Expect = 1e-16
Identities = 67/238 (28%), Positives = 112/238 (47%), Gaps = 14/238 (5%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G V V ++L + G T LH +A G++ VR + +GA+ +
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
GFT L+ AA + + +LE+ N + DG+TPL VA G ++ V L+
Sbjct: 109 Q-KGFTPLYMAAQENHLEVVKFLLENGANQ---NVATEDGFTPLAVALQQGHENVVAHLI 164
Query: 138 EFKAEVDPLSDKGTTP-LQLAIIRERSSCVKILLDHNANIDI--QNGFL-LRYAVIKSNH 193
+ + K P L +A + + +LL ++ N D+ + GF L A N
Sbjct: 165 NYGTK-----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219
Query: 194 SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
+ ++ L RGA N ++G TPLH+++ R +V+ R+L + GA T+ + TPL
Sbjct: 220 NVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276
Score = 73.2 bits (178), Expect = 3e-13
Identities = 67/248 (27%), Positives = 102/248 (41%), Gaps = 35/248 (14%)
Query: 38 YSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIA 97
YS R+A+ T +A G L +G D + G LH A+ G ++
Sbjct: 3 YSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQ-NGLNGLHLASKEGHVKMV 61
Query: 98 RLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLA 157
+L E I+ + G T LH+AA G+D VR L+ + A V+ S KG TPL +A
Sbjct: 62 VELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118
Query: 158 IIRERSSCVKILLDH--NANIDIQNGFLLRYAVIKSNHSYCRMFL--------------- 200
VK LL++ N N+ ++GF ++ H L
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH 178
Query: 201 --QRGADTNLGRL------------EDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYE 246
R DT + + G TPLH++A +++ A++L N GA N
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 247 GQTPLAVS 254
G TPL ++
Sbjct: 239 GITPLHIA 246
Score = 49.7 bits (117), Expect = 3e-06
Identities = 34/112 (30%), Positives = 53/112 (47%), Gaps = 4/112 (3%)
Query: 25 GDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTA 84
G V +++ G + G+T LH ++ G + V+ L+H AD K +G ++
Sbjct: 679 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG-YSP 737
Query: 85 LHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLL 136
LH AA G I L+L++ N S+DG TPL +A G S +L
Sbjct: 738 LHQAAQQGHTDIVTLLLKNGASP---NEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 48.1 bits (113), Expect = 1e-05
Identities = 35/146 (23%), Positives = 64/146 (43%), Gaps = 31/146 (21%)
Query: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
IN + +G LH+A+ G V LL + ++ + KG T L +A + + V+ L
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 170 LDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLC 229
+++ AN++ Q+ + G TPL+++A + +
Sbjct: 98 VNYGANVNAQS-------------------------------QKGFTPLYMAAQENHLEV 126
Query: 230 ARMLYNYGADTNTRNYEGQTPLAVSI 255
+ L GA+ N +G TPLAV++
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVAL 152
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 103 bits (257), Expect = 2e-22
Identities = 75/229 (32%), Positives = 113/229 (49%), Gaps = 8/229 (3%)
Query: 26 DVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTAL 85
+++ + +L +G S N NG T LH ++ RG VR+ L+ GA K T L
Sbjct: 218 NLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPL 276
Query: 86 HYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDP 145
H AA +G RI+ ++L+ I AK+ +G +P+H+AA VRLLL++ AE+D
Sbjct: 277 HCAARNGHVRISEILLD---HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 146 LSDKGTTPLQLAIIRERSSCVKILLDHNA--NIDIQNGFLLRYAVIKSNH-SYCRMFLQR 202
++ TPL +A K+LLD A N NGF + K NH + L+
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 203 GADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
GA + E G TPLH+++ + + L GA N N + +TPL
Sbjct: 394 GASID-AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Score = 100 bits (250), Expect = 1e-21
Identities = 76/244 (31%), Positives = 111/244 (45%), Gaps = 8/244 (3%)
Query: 14 EELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADP 73
++ + A G + V+ +LE +PN G T LH +A G V LE A
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529
Query: 74 TVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFV 133
GFT LH AA +G+ R+A L+LE + NA +G TPLHVA H+ V
Sbjct: 530 ACMTK-KGFTPLHVAAKYGKVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIV 585
Query: 134 RLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDH--NANIDIQNGFLLRYAVIKS 191
+LLL + G TPL +A + + + LL + +AN + G + +
Sbjct: 586 KLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 645
Query: 192 NHS-YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTP 250
H+ + L + A+ NLG + G TPLHL A V A +L +G + G TP
Sbjct: 646 GHAEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 704
Query: 251 LAVS 254
L V+
Sbjct: 705 LHVA 708
Score = 96.3 bits (238), Expect = 3e-20
Identities = 69/237 (29%), Positives = 115/237 (48%), Gaps = 12/237 (5%)
Query: 21 AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
A + V+ +LE G + N +G+T L + +G E V + +G V+
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR---- 173
Query: 81 GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
ALH AA + R A ++L+++ D++ S G+TPLH+AAHY + +LLL
Sbjct: 174 -LPALHIAARNDDTRTAAVLLQNDPNPDVL---SKTGFTPLHIAAHYENLNVAQLLLNRG 229
Query: 141 AEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCR--- 197
A V+ G TPL +A R V++LLD A I+ + L + + + R
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 198 MFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
+ L GA + ++G +P+H++A D + C R+L Y A+ + + TPL V+
Sbjct: 290 ILLDHGAPIQ-AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345
Score = 93.6 bits (231), Expect = 2e-19
Identities = 69/242 (28%), Positives = 110/242 (45%), Gaps = 10/242 (4%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA--DPTV 75
+ A G + +L++G PN R NG+T LH + + R + + L+ GA D
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 76 KDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRL 135
+ G T LH A+ G I + +L+ ++ N K TPLH+AA G +
Sbjct: 402 E---SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE---TPLHMAARAGHTEVAKY 455
Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFLLRYAVIKSNH 193
LL+ KA+V+ + TPL A ++ VK+LL++NAN ++ G + + H
Sbjct: 456 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Query: 194 SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAV 253
+ L + + G TPLH++A V A +L A N G TPL V
Sbjct: 516 VETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575
Query: 254 SI 255
++
Sbjct: 576 AV 577
Score = 93.6 bits (231), Expect = 2e-19
Identities = 78/270 (28%), Positives = 123/270 (45%), Gaps = 41/270 (15%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A V + +L+ G S + +G T LH ++ G V+ L+ GA P V +
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
+ T LH AA G +A+ +L+++ + +NAK+ D TPLH AA G + V+LLL
Sbjct: 435 -VKVETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARIGHTNMVKLLL 490
Query: 138 EFKAEVDPLSDKGTTPLQ-----------LAIIRERSS---------------------- 164
E A + + G TPL LA++ + +S
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550
Query: 165 CVKILLDHNA--NIDIQNGFL-LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLS 221
++LL+ +A N +NG L AV +N ++ L RG + +G TPLH++
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SPAWNGYTPLHIA 609
Query: 222 ALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
A ++ V AR L YG N + +G TPL
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPL 639
Score = 92.8 bits (229), Expect = 4e-19
Identities = 72/240 (30%), Positives = 103/240 (42%), Gaps = 8/240 (3%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G V +LE+ PN NG T LH + V++ L G P
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SP 598
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
G+T LH AA + +AR +L+ NA+S G TPLH+AA G V LLL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQY---GGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFL-LRYAVIKSNHS 194
+A + + G TPL L +L+ H +D G+ L A N
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
+ LQ AD N + + G +PLH +A + +L GA N + +G TPLA++
Sbjct: 716 LVKFLLQHQADVN-AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 90.5 bits (223), Expect = 2e-18
Identities = 69/237 (29%), Positives = 107/237 (45%), Gaps = 8/237 (3%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G V TV +LE+ S G+T LH +A GK R + LE A P
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
G T LH A H I +L+L R ++ + +G+TPLH+AA + R LL
Sbjct: 567 K-NGLTPLHVAVHHNNLDIVKLLLP---RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFLLRYAVIKSNH-S 194
++ + S +G TPL LA + V +LL AN ++ N G + V + H
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
+ ++ G + G TPLH+++ ++ + L + AD N + G +PL
Sbjct: 683 VADVLIKHGVMVD-ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPL 738
Score = 88.6 bits (218), Expect = 7e-18
Identities = 69/207 (33%), Positives = 102/207 (49%), Gaps = 8/207 (3%)
Query: 51 LHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDII 110
LH +A R V L++ +P V G FT LH AA + +A+L+L R +
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTG-FTPLHIAAHYENLNVAQLLLN---RGASV 232
Query: 111 NAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL 170
N +G TPLH+A+ G VRLLL+ A+++ + TPL A +ILL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 171 DHNANIDIQ--NGFLLRYAVIKSNHSYC-RMFLQRGADTNLGRLEDGQTPLHLSALRDDV 227
DH A I + NG + + +H C R+ LQ A+ + L D TPLH++A
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL-DHLTPLHVAAHCGHH 351
Query: 228 LCARMLYNYGADTNTRNYEGQTPLAVS 254
A++L + GA N+R G TPL ++
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIA 378
Score = 84.7 bits (208), Expect = 1e-16
Identities = 67/238 (28%), Positives = 112/238 (47%), Gaps = 14/238 (5%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G V V ++L + G T LH +A G++ VR + +GA+ +
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
GFT L+ AA + + +LE+ N + DG+TPL VA G ++ V L+
Sbjct: 109 Q-KGFTPLYMAAQENHLEVVKFLLENGANQ---NVATEDGFTPLAVALQQGHENVVAHLI 164
Query: 138 EFKAEVDPLSDKGTTP-LQLAIIRERSSCVKILLDHNANIDI--QNGFL-LRYAVIKSNH 193
+ + K P L +A + + +LL ++ N D+ + GF L A N
Sbjct: 165 NYGTK-----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219
Query: 194 SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
+ ++ L RGA N ++G TPLH+++ R +V+ R+L + GA T+ + TPL
Sbjct: 220 NVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276
Score = 73.2 bits (178), Expect = 3e-13
Identities = 67/248 (27%), Positives = 102/248 (41%), Gaps = 35/248 (14%)
Query: 38 YSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIA 97
YS R+A+ T +A G L +G D + G LH A+ G ++
Sbjct: 3 YSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQ-NGLNGLHLASKEGHVKMV 61
Query: 98 RLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLA 157
+L E I+ + G T LH+AA G+D VR L+ + A V+ S KG TPL +A
Sbjct: 62 VELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118
Query: 158 IIRERSSCVKILLDH--NANIDIQNGFLLRYAVIKSNHSYCRMFL--------------- 200
VK LL++ N N+ ++GF ++ H L
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH 178
Query: 201 --QRGADTNLGRL------------EDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYE 246
R DT + + G TPLH++A +++ A++L N GA N
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 247 GQTPLAVS 254
G TPL ++
Sbjct: 239 GITPLHIA 246
Score = 49.7 bits (117), Expect = 3e-06
Identities = 34/112 (30%), Positives = 53/112 (47%), Gaps = 4/112 (3%)
Query: 25 GDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTA 84
G V +++ G + G+T LH ++ G + V+ L+H AD K +G ++
Sbjct: 679 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG-YSP 737
Query: 85 LHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLL 136
LH AA G I L+L++ N S+DG TPL +A G S +L
Sbjct: 738 LHQAAQQGHTDIVTLLLKNGASP---NEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 48.1 bits (113), Expect = 1e-05
Identities = 35/146 (23%), Positives = 64/146 (43%), Gaps = 31/146 (21%)
Query: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
IN + +G LH+A+ G V LL + ++ + KG T L +A + + V+ L
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 170 LDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLC 229
+++ AN++ Q+ + G TPL+++A + +
Sbjct: 98 VNYGANVNAQS-------------------------------QKGFTPLYMAAQENHLEV 126
Query: 230 ARMLYNYGADTNTRNYEGQTPLAVSI 255
+ L GA+ N +G TPLAV++
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVAL 152
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 103 bits (257), Expect = 2e-22
Identities = 75/229 (32%), Positives = 113/229 (49%), Gaps = 8/229 (3%)
Query: 26 DVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTAL 85
+++ + +L +G S N NG T LH ++ RG VR+ L+ GA K T L
Sbjct: 218 NLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPL 276
Query: 86 HYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDP 145
H AA +G RI+ ++L+ I AK+ +G +P+H+AA VRLLL++ AE+D
Sbjct: 277 HCAARNGHVRISEILLD---HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 146 LSDKGTTPLQLAIIRERSSCVKILLDHNA--NIDIQNGFLLRYAVIKSNH-SYCRMFLQR 202
++ TPL +A K+LLD A N NGF + K NH + L+
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 203 GADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
GA + E G TPLH+++ + + L GA N N + +TPL
Sbjct: 394 GASID-AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Score = 100 bits (250), Expect = 1e-21
Identities = 76/244 (31%), Positives = 111/244 (45%), Gaps = 8/244 (3%)
Query: 14 EELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADP 73
++ + A G + V+ +LE +PN G T LH +A G V LE A
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529
Query: 74 TVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFV 133
GFT LH AA +G+ R+A L+LE + NA +G TPLHVA H+ V
Sbjct: 530 ACMTK-KGFTPLHVAAKYGKVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIV 585
Query: 134 RLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDH--NANIDIQNGFLLRYAVIKS 191
+LLL + G TPL +A + + + LL + +AN + G + +
Sbjct: 586 KLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 645
Query: 192 NHS-YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTP 250
H+ + L + A+ NLG + G TPLHL A V A +L +G + G TP
Sbjct: 646 GHAEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 704
Query: 251 LAVS 254
L V+
Sbjct: 705 LHVA 708
Score = 96.3 bits (238), Expect = 3e-20
Identities = 69/237 (29%), Positives = 115/237 (48%), Gaps = 12/237 (5%)
Query: 21 AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
A + V+ +LE G + N +G+T L + +G E V + +G V+
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR---- 173
Query: 81 GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
ALH AA + R A ++L+++ D++ S G+TPLH+AAHY + +LLL
Sbjct: 174 -LPALHIAARNDDTRTAAVLLQNDPNPDVL---SKTGFTPLHIAAHYENLNVAQLLLNRG 229
Query: 141 AEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCR--- 197
A V+ G TPL +A R V++LLD A I+ + L + + + R
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 198 MFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
+ L GA + ++G +P+H++A D + C R+L Y A+ + + TPL V+
Sbjct: 290 ILLDHGAPIQ-AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345
Score = 93.6 bits (231), Expect = 2e-19
Identities = 69/242 (28%), Positives = 110/242 (45%), Gaps = 10/242 (4%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA--DPTV 75
+ A G + +L++G PN R NG+T LH + + R + + L+ GA D
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 76 KDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRL 135
+ G T LH A+ G I + +L+ ++ N K TPLH+AA G +
Sbjct: 402 E---SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE---TPLHMAARAGHTEVAKY 455
Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFLLRYAVIKSNH 193
LL+ KA+V+ + TPL A ++ VK+LL++NAN ++ G + + H
Sbjct: 456 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Query: 194 SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAV 253
+ L + + G TPLH++A V A +L A N G TPL V
Sbjct: 516 VETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575
Query: 254 SI 255
++
Sbjct: 576 AV 577
Score = 93.6 bits (231), Expect = 2e-19
Identities = 78/270 (28%), Positives = 123/270 (45%), Gaps = 41/270 (15%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A V + +L+ G S + +G T LH ++ G V+ L+ GA P V +
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
+ T LH AA G +A+ +L+++ + +NAK+ D TPLH AA G + V+LLL
Sbjct: 435 -VKVETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARIGHTNMVKLLL 490
Query: 138 EFKAEVDPLSDKGTTPLQ-----------LAIIRERSS---------------------- 164
E A + + G TPL LA++ + +S
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550
Query: 165 CVKILLDHNA--NIDIQNGFL-LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLS 221
++LL+ +A N +NG L AV +N ++ L RG + +G TPLH++
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SPAWNGYTPLHIA 609
Query: 222 ALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
A ++ V AR L YG N + +G TPL
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPL 639
Score = 92.8 bits (229), Expect = 4e-19
Identities = 72/240 (30%), Positives = 103/240 (42%), Gaps = 8/240 (3%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G V +LE+ PN NG T LH + V++ L G P
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SP 598
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
G+T LH AA + +AR +L+ NA+S G TPLH+AA G V LLL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQY---GGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFL-LRYAVIKSNHS 194
+A + + G TPL L +L+ H +D G+ L A N
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
+ LQ AD N + + G +PLH +A + +L GA N + +G TPLA++
Sbjct: 716 LVKFLLQHQADVN-AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 90.5 bits (223), Expect = 2e-18
Identities = 69/237 (29%), Positives = 107/237 (45%), Gaps = 8/237 (3%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G V TV +LE+ S G+T LH +A GK R + LE A P
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
G T LH A H I +L+L R ++ + +G+TPLH+AA + R LL
Sbjct: 567 K-NGLTPLHVAVHHNNLDIVKLLLP---RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFLLRYAVIKSNH-S 194
++ + S +G TPL LA + V +LL AN ++ N G + V + H
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
+ ++ G + G TPLH+++ ++ + L + AD N + G +PL
Sbjct: 683 VADVLIKHGVMVD-ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPL 738
Score = 88.6 bits (218), Expect = 7e-18
Identities = 69/207 (33%), Positives = 102/207 (49%), Gaps = 8/207 (3%)
Query: 51 LHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDII 110
LH +A R V L++ +P V G FT LH AA + +A+L+L R +
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTG-FTPLHIAAHYENLNVAQLLLN---RGASV 232
Query: 111 NAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL 170
N +G TPLH+A+ G VRLLL+ A+++ + TPL A +ILL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 171 DHNANIDIQ--NGFLLRYAVIKSNHSYC-RMFLQRGADTNLGRLEDGQTPLHLSALRDDV 227
DH A I + NG + + +H C R+ LQ A+ + L D TPLH++A
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL-DHLTPLHVAAHCGHH 351
Query: 228 LCARMLYNYGADTNTRNYEGQTPLAVS 254
A++L + GA N+R G TPL ++
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIA 378
Score = 84.7 bits (208), Expect = 1e-16
Identities = 67/238 (28%), Positives = 112/238 (47%), Gaps = 14/238 (5%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G V V ++L + G T LH +A G++ VR + +GA+ +
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
GFT L+ AA + + +LE+ N + DG+TPL VA G ++ V L+
Sbjct: 109 Q-KGFTPLYMAAQENHLEVVKFLLENGANQ---NVATEDGFTPLAVALQQGHENVVAHLI 164
Query: 138 EFKAEVDPLSDKGTTP-LQLAIIRERSSCVKILLDHNANIDI--QNGFL-LRYAVIKSNH 193
+ + K P L +A + + +LL ++ N D+ + GF L A N
Sbjct: 165 NYGTK-----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219
Query: 194 SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
+ ++ L RGA N ++G TPLH+++ R +V+ R+L + GA T+ + TPL
Sbjct: 220 NVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276
Score = 73.2 bits (178), Expect = 3e-13
Identities = 67/248 (27%), Positives = 102/248 (41%), Gaps = 35/248 (14%)
Query: 38 YSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIA 97
YS R+A+ T +A G L +G D + G LH A+ G ++
Sbjct: 3 YSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQ-NGLNGLHLASKEGHVKMV 61
Query: 98 RLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLA 157
+L E I+ + G T LH+AA G+D VR L+ + A V+ S KG TPL +A
Sbjct: 62 VELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118
Query: 158 IIRERSSCVKILLDH--NANIDIQNGFLLRYAVIKSNHSYCRMFL--------------- 200
VK LL++ N N+ ++GF ++ H L
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH 178
Query: 201 --QRGADTNLGRL------------EDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYE 246
R DT + + G TPLH++A +++ A++L N GA N
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 247 GQTPLAVS 254
G TPL ++
Sbjct: 239 GITPLHIA 246
Score = 49.7 bits (117), Expect = 3e-06
Identities = 34/112 (30%), Positives = 53/112 (47%), Gaps = 4/112 (3%)
Query: 25 GDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTA 84
G V +++ G + G+T LH ++ G + V+ L+H AD K +G ++
Sbjct: 679 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG-YSP 737
Query: 85 LHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLL 136
LH AA G I L+L++ N S+DG TPL +A G S +L
Sbjct: 738 LHQAAQQGHTDIVTLLLKNGASP---NEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 48.1 bits (113), Expect = 1e-05
Identities = 35/146 (23%), Positives = 64/146 (43%), Gaps = 31/146 (21%)
Query: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
IN + +G LH+A+ G V LL + ++ + KG T L +A + + V+ L
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 170 LDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLC 229
+++ AN++ Q+ + G TPL+++A + +
Sbjct: 98 VNYGANVNAQS-------------------------------QKGFTPLYMAAQENHLEV 126
Query: 230 ARMLYNYGADTNTRNYEGQTPLAVSI 255
+ L GA+ N +G TPLAV++
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVAL 152
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 103 bits (257), Expect = 2e-22
Identities = 75/229 (32%), Positives = 113/229 (49%), Gaps = 8/229 (3%)
Query: 26 DVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTAL 85
+++ + +L +G S N NG T LH ++ RG VR+ L+ GA K T L
Sbjct: 218 NLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPL 276
Query: 86 HYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDP 145
H AA +G RI+ ++L+ I AK+ +G +P+H+AA VRLLL++ AE+D
Sbjct: 277 HCAARNGHVRISEILLD---HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 146 LSDKGTTPLQLAIIRERSSCVKILLDHNA--NIDIQNGFLLRYAVIKSNH-SYCRMFLQR 202
++ TPL +A K+LLD A N NGF + K NH + L+
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 203 GADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
GA + E G TPLH+++ + + L GA N N + +TPL
Sbjct: 394 GASID-AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Score = 100 bits (250), Expect = 1e-21
Identities = 76/244 (31%), Positives = 111/244 (45%), Gaps = 8/244 (3%)
Query: 14 EELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADP 73
++ + A G + V+ +LE +PN G T LH +A G V LE A
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQ 529
Query: 74 TVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFV 133
GFT LH AA +G+ R+A L+LE + NA +G TPLHVA H+ V
Sbjct: 530 ACMTK-KGFTPLHVAAKYGKVRVAELLLERDAHP---NAAGKNGLTPLHVAVHHNNLDIV 585
Query: 134 RLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDH--NANIDIQNGFLLRYAVIKS 191
+LLL + G TPL +A + + + LL + +AN + G + +
Sbjct: 586 KLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQE 645
Query: 192 NHS-YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTP 250
H+ + L + A+ NLG + G TPLHL A V A +L +G + G TP
Sbjct: 646 GHAEMVALLLSKQANGNLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTP 704
Query: 251 LAVS 254
L V+
Sbjct: 705 LHVA 708
Score = 96.3 bits (238), Expect = 3e-20
Identities = 69/237 (29%), Positives = 115/237 (48%), Gaps = 12/237 (5%)
Query: 21 AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
A + V+ +LE G + N +G+T L + +G E V + +G V+
Sbjct: 118 AAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR---- 173
Query: 81 GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
ALH AA + R A ++L+++ D++ S G+TPLH+AAHY + +LLL
Sbjct: 174 -LPALHIAARNDDTRTAAVLLQNDPNPDVL---SKTGFTPLHIAAHYENLNVAQLLLNRG 229
Query: 141 AEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCR--- 197
A V+ G TPL +A R V++LLD A I+ + L + + + R
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 198 MFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
+ L GA + ++G +P+H++A D + C R+L Y A+ + + TPL V+
Sbjct: 290 ILLDHGAPIQ-AKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345
Score = 93.6 bits (231), Expect = 2e-19
Identities = 69/242 (28%), Positives = 110/242 (45%), Gaps = 10/242 (4%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA--DPTV 75
+ A G + +L++G PN R NG+T LH + + R + + L+ GA D
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 76 KDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRL 135
+ G T LH A+ G I + +L+ ++ N K TPLH+AA G +
Sbjct: 402 E---SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE---TPLHMAARAGHTEVAKY 455
Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFLLRYAVIKSNH 193
LL+ KA+V+ + TPL A ++ VK+LL++NAN ++ G + + H
Sbjct: 456 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Query: 194 SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAV 253
+ L + + G TPLH++A V A +L A N G TPL V
Sbjct: 516 VETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575
Query: 254 SI 255
++
Sbjct: 576 AV 577
Score = 93.6 bits (231), Expect = 2e-19
Identities = 78/270 (28%), Positives = 123/270 (45%), Gaps = 41/270 (15%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A V + +L+ G S + +G T LH ++ G V+ L+ GA P V +
Sbjct: 375 LHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSN 434
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
+ T LH AA G +A+ +L+++ + +NAK+ D TPLH AA G + V+LLL
Sbjct: 435 -VKVETPLHMAARAGHTEVAKYLLQNKAK---VNAKAKDDQTPLHCAARIGHTNMVKLLL 490
Query: 138 EFKAEVDPLSDKGTTPLQ-----------LAIIRERSS---------------------- 164
E A + + G TPL LA++ + +S
Sbjct: 491 ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVR 550
Query: 165 CVKILLDHNA--NIDIQNGFL-LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLS 221
++LL+ +A N +NG L AV +N ++ L RG + +G TPLH++
Sbjct: 551 VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SPAWNGYTPLHIA 609
Query: 222 ALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
A ++ V AR L YG N + +G TPL
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPL 639
Score = 92.8 bits (229), Expect = 4e-19
Identities = 72/240 (30%), Positives = 103/240 (42%), Gaps = 8/240 (3%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G V +LE+ PN NG T LH + V++ L G P
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SP 598
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
G+T LH AA + +AR +L+ NA+S G TPLH+AA G V LLL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQY---GGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFL-LRYAVIKSNHS 194
+A + + G TPL L +L+ H +D G+ L A N
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
+ LQ AD N + + G +PLH +A + +L GA N + +G TPLA++
Sbjct: 716 LVKFLLQHQADVN-AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 90.5 bits (223), Expect = 2e-18
Identities = 69/237 (29%), Positives = 107/237 (45%), Gaps = 8/237 (3%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G V TV +LE+ S G+T LH +A GK R + LE A P
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
G T LH A H I +L+L R ++ + +G+TPLH+AA + R LL
Sbjct: 567 K-NGLTPLHVAVHHNNLDIVKLLLP---RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN--GFLLRYAVIKSNH-S 194
++ + S +G TPL LA + V +LL AN ++ N G + V + H
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
+ ++ G + G TPLH+++ ++ + L + AD N + G +PL
Sbjct: 683 VADVLIKHGVMVD-ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPL 738
Score = 88.6 bits (218), Expect = 7e-18
Identities = 69/207 (33%), Positives = 102/207 (49%), Gaps = 8/207 (3%)
Query: 51 LHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDII 110
LH +A R V L++ +P V G FT LH AA + +A+L+L R +
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTG-FTPLHIAAHYENLNVAQLLLN---RGASV 232
Query: 111 NAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL 170
N +G TPLH+A+ G VRLLL+ A+++ + TPL A +ILL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 171 DHNANIDIQ--NGFLLRYAVIKSNHSYC-RMFLQRGADTNLGRLEDGQTPLHLSALRDDV 227
DH A I + NG + + +H C R+ LQ A+ + L D TPLH++A
Sbjct: 293 DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL-DHLTPLHVAAHCGHH 351
Query: 228 LCARMLYNYGADTNTRNYEGQTPLAVS 254
A++L + GA N+R G TPL ++
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIA 378
Score = 84.7 bits (208), Expect = 1e-16
Identities = 67/238 (28%), Positives = 112/238 (47%), Gaps = 14/238 (5%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G V V ++L + G T LH +A G++ VR + +GA+ +
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
GFT L+ AA + + +LE+ N + DG+TPL VA G ++ V L+
Sbjct: 109 Q-KGFTPLYMAAQENHLEVVKFLLENGANQ---NVATEDGFTPLAVALQQGHENVVAHLI 164
Query: 138 EFKAEVDPLSDKGTTP-LQLAIIRERSSCVKILLDHNANIDI--QNGFL-LRYAVIKSNH 193
+ + K P L +A + + +LL ++ N D+ + GF L A N
Sbjct: 165 NYGTK-----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219
Query: 194 SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
+ ++ L RGA N ++G TPLH+++ R +V+ R+L + GA T+ + TPL
Sbjct: 220 NVAQLLLNRGASVNF-TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL 276
Score = 73.2 bits (178), Expect = 3e-13
Identities = 67/248 (27%), Positives = 102/248 (41%), Gaps = 35/248 (14%)
Query: 38 YSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIA 97
YS R+A+ T +A G L +G D + G LH A+ G ++
Sbjct: 3 YSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQ-NGLNGLHLASKEGHVKMV 61
Query: 98 RLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLA 157
+L E I+ + G T LH+AA G+D VR L+ + A V+ S KG TPL +A
Sbjct: 62 VELLHKEI---ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118
Query: 158 IIRERSSCVKILLDH--NANIDIQNGFLLRYAVIKSNHSYCRMFL--------------- 200
VK LL++ N N+ ++GF ++ H L
Sbjct: 119 AQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALH 178
Query: 201 --QRGADTNLGRL------------EDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYE 246
R DT + + G TPLH++A +++ A++L N GA N
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 247 GQTPLAVS 254
G TPL ++
Sbjct: 239 GITPLHIA 246
Score = 49.7 bits (117), Expect = 3e-06
Identities = 34/112 (30%), Positives = 53/112 (47%), Gaps = 4/112 (3%)
Query: 25 GDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTA 84
G V +++ G + G+T LH ++ G + V+ L+H AD K +G ++
Sbjct: 679 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG-YSP 737
Query: 85 LHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLL 136
LH AA G I L+L++ N S+DG TPL +A G S +L
Sbjct: 738 LHQAAQQGHTDIVTLLLKNGASP---NEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 48.1 bits (113), Expect = 1e-05
Identities = 35/146 (23%), Positives = 64/146 (43%), Gaps = 31/146 (21%)
Query: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
IN + +G LH+A+ G V LL + ++ + KG T L +A + + V+ L
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 170 LDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLC 229
+++ AN++ Q+ + G TPL+++A + +
Sbjct: 98 VNYGANVNAQS-------------------------------QKGFTPLYMAAQENHLEV 126
Query: 230 ARMLYNYGADTNTRNYEGQTPLAVSI 255
+ L GA+ N +G TPLAV++
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVAL 152
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 102 bits (254), Expect = 4e-22
Identities = 76/233 (32%), Positives = 113/233 (48%), Gaps = 8/233 (3%)
Query: 22 VAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGG 81
VA G V VR +L + + A+G+T L +A + + L HGAD D G
Sbjct: 370 VAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDE-DG 428
Query: 82 FTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKA 141
+ LH+AA +G ARL+L+ ++A+ +GWTPLH+AA ++ RLL+ +A
Sbjct: 429 WAPLHFAAQNGDDGTARLLLD---HGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQA 485
Query: 142 EVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFL---LRYAVIKSNHSYCRM 198
+ + +G TPL +A S VK+L A +D Q L L AV + +
Sbjct: 486 DPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQH 545
Query: 199 FLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
L+ GA + + G PLH +A R L +ML YGA ++G TPL
Sbjct: 546 LLKSGAVPD-ALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPL 597
Score = 102 bits (253), Expect = 6e-22
Identities = 72/241 (29%), Positives = 113/241 (46%), Gaps = 41/241 (17%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGAD---PT 74
+ AV G V ++ +L+ G P+ D +G+ LH +AARGK ++ L +GA PT
Sbjct: 531 LHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPT 590
Query: 75 VKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVR 134
+ G+T LH AA G I L+ ES + A + WTPLH+AA +G ++ V
Sbjct: 591 HQ----GWTPLHLAAYKGHLEIIHLLAESHANMGALGAVN---WTPLHLAARHGEEAVVS 643
Query: 135 LLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHS 194
LL+ A+ + G TPL LA+ R V LL+H+AN+ +N
Sbjct: 644 ALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARN-------------- 689
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
+ G TP HL+AL+ + ++L GA + ++ TPL ++
Sbjct: 690 -----------------KVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLA 732
Query: 255 I 255
+
Sbjct: 733 L 733
Score = 92.8 bits (229), Expect = 4e-19
Identities = 72/242 (29%), Positives = 108/242 (44%), Gaps = 10/242 (4%)
Query: 21 AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
A GD T R +L+ G + ++ GWT LH +A E R+ + ADP + +
Sbjct: 435 AAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE-AE 493
Query: 81 GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
G T LH AA G + +L+ D A+ + TPLH+A G+ ++ LL+
Sbjct: 494 GKTPLHVAAYFGHVSLVKLLTSQGAELD---AQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
Query: 141 AEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDI---QNGFLLRYAVIKSNHSYCR 197
A D L G PL A R + K+LL + A++++ Q L A K +
Sbjct: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
Query: 198 MFLQRGADTNLGRL-EDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSIS 256
+ + A N+G L TPLHL+A + L GAD N G TPL +++
Sbjct: 611 LLAESHA--NMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQ 668
Query: 257 IS 258
S
Sbjct: 669 RS 670
Score = 70.9 bits (172), Expect = 1e-12
Identities = 46/160 (28%), Positives = 72/160 (45%), Gaps = 4/160 (2%)
Query: 10 PELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEH 69
P Q + A G + + + E + A WT LH +A G+E V L+
Sbjct: 589 PTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQC 648
Query: 70 GADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGR 129
GADP + G+T LH A +LE ++A++ GWTP H+AA G
Sbjct: 649 GADPNAAEQ-SGWTPLHLAVQRSTFLSVINLLEHHAN---VHARNKVGWTPAHLAALKGN 704
Query: 130 DSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
+ +++L+E A++D TPLQLA+ + + L
Sbjct: 705 TAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
Score = 67.4 bits (163), Expect = 2e-11
Identities = 55/166 (33%), Positives = 78/166 (46%), Gaps = 6/166 (3%)
Query: 119 TPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNAN--- 175
TPLH G VRLLL + +VD + G TPL +A ++ +LL H A+
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 176 IDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYN 235
+D L +A + R+ L GA + + +G TPLHL+A + AR+L +
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVD-AQEREGWTPLHLAAQNNFENVARLLVS 482
Query: 236 YGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQ--EVTRQPRNLQ 279
AD N EG+TPL V+ S L Q E+ Q RNL+
Sbjct: 483 RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLR 528
Score = 28.9 bits (63), Expect = 6.3
Identities = 29/133 (21%), Positives = 50/133 (37%), Gaps = 12/133 (9%)
Query: 129 RDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAV 188
R F+ + +E + L + P A+ R+ S + + N DI +
Sbjct: 275 RPCFLDITIETDILLSLLQSRVAVPESKALARKVSCKLSLRQPGEVNEDISQELM----- 329
Query: 189 IKSNHSYCRMFLQRG-------ADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTN 241
+ +Y + LQ D L E+ TPLH + V R+L + D +
Sbjct: 330 DSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVD 389
Query: 242 TRNYEGQTPLAVS 254
+ G TPL ++
Sbjct: 390 CQTASGYTPLLIA 402
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 102 bits (253), Expect = 6e-22
Identities = 77/263 (29%), Positives = 123/263 (46%), Gaps = 10/263 (3%)
Query: 10 PELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKER-CVRVFLE 68
P + A G V ++++ G N ++ G+T LHF+AA C+ + +
Sbjct: 235 PNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVG 294
Query: 69 HGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYG 128
+GAD +K G T LH A+HGR ++ +++S +I+ + +G TPLH+AA YG
Sbjct: 295 NGADVNMKSK-DGKTPLHMTALHGRFSRSQTIIQS---GAVIDCEDKNGNTPLHIAARYG 350
Query: 129 RDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGF---LLR 185
+ + L+ A+ G PL LA + S C + LL +ID + F L
Sbjct: 351 HELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLH 410
Query: 186 YAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNY 245
A N + L GAD N + + G++PLH +A + C L GA N +
Sbjct: 411 AAAAGGNLECLNLLLNTGADFN-KKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDE 469
Query: 246 EGQTPLAVSISISGSSRPCLDFL 268
G TPL + + S + CL++L
Sbjct: 470 RGCTPLHYA-ATSDTDGKCLEYL 491
Score = 100 bits (249), Expect = 2e-21
Identities = 69/236 (29%), Positives = 119/236 (50%), Gaps = 19/236 (8%)
Query: 33 MLEQGYSPNGRDANGWTLLHFSAARGKE-RCVRVFLEHGADPTVKDLIGGFTALHYAAMH 91
++ G S N D G T LH++A + +C+ L + A+P ++D G+ A+HY+A +
Sbjct: 457 LVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDK-QGYNAVHYSAAY 515
Query: 92 GRARIARLMLESEYRSDIINAKSNDGW----------TPLHVAAHYGRDSFVRLLLEFKA 141
G R+ ++ SE D++ S +PLH+AA++G + +L++
Sbjct: 516 GH-RLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLL 574
Query: 142 EVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLR---YAVIKSNHSYC-R 197
++D + G TPL LA + CV +L++ A+I +++ L R +A + HS C R
Sbjct: 575 DLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLR 634
Query: 198 MFLQRGADTNLGRLED--GQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
+ + N ++D GQTPL LS L C L N GA+ + ++ G+T L
Sbjct: 635 LLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTAL 690
Score = 94.0 bits (232), Expect = 2e-19
Identities = 76/238 (31%), Positives = 106/238 (44%), Gaps = 9/238 (3%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ AVA+ V+ +L+ N RD N T LH +AA +C + ++ V D
Sbjct: 78 LHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSD 137
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
G TALH+AA G + +L+L R INA +H AA+ G V+LL+
Sbjct: 138 R-AGRTALHHAAFSGHGEMVKLLLS---RGANINAFDKKDRRAIHWAAYMGHIEVVKLLV 193
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGF---LLRYAVIKSNHS 194
AEV K TPL A S VK LLD +++ N + L A
Sbjct: 194 SHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDV 253
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSAL-RDDVLCARMLYNYGADTNTRNYEGQTPL 251
+ GA N + E G TPLH +A LC +L GAD N ++ +G+TPL
Sbjct: 254 VVNELIDCGAIVN-QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPL 310
Score = 87.8 bits (216), Expect = 1e-17
Identities = 73/266 (27%), Positives = 115/266 (43%), Gaps = 45/266 (16%)
Query: 3 HHHCRR----NPELQEELQIQ---------AAVAAGDVHTVRKMLEQGYSPNGRDANGWT 49
H C R N E Q + IQ +V G V +L +G + + +D G T
Sbjct: 629 HSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRT 688
Query: 50 LLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDI 109
LH A G E CV L+HGA ++D G T +H +A G + +L+S D
Sbjct: 689 ALHRGAVTGHEECVDALLQHGAKCLLRD-SRGRTPIHLSAACGHIGVLGALLQSAASMDA 747
Query: 110 INAKS-NDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKI 168
A + N G+T LH A + G ++ V LLLE + +PL A+I + ++
Sbjct: 748 NPATADNHGYTALHWACYNGHETCVELLLE-QEVFQKTEGNAFSPLHCAVINDNEGAAEM 806
Query: 169 LLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVL 228
L+D L +++ + S G+TPLH +A D V
Sbjct: 807 LID-----------TLGASIVNATDS------------------KGRTPLHAAAFTDHVE 837
Query: 229 CARMLYNYGADTNTRNYEGQTPLAVS 254
C ++L ++ A N+ + G+TPL ++
Sbjct: 838 CLQLLLSHNAQVNSVDSTGKTPLMMA 863
Score = 84.7 bits (208), Expect = 1e-16
Identities = 65/243 (26%), Positives = 114/243 (46%), Gaps = 13/243 (5%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYS----PNGRDANGWTLLHFSAARGKERCVRVFLEHGADP 73
I + A G + + +L+ S P D +G+T LH++ G E CV + LE
Sbjct: 723 IHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQ 782
Query: 74 TVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFV 133
+ F+ LH A ++ A +++++ + I+NA + G TPLH AA +
Sbjct: 783 KTEG--NAFSPLHCAVINDNEGAAEMLIDT-LGASIVNATDSKGRTPLHAAAFTDHVECL 839
Query: 134 RLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDH-NANIDIQN---GFLLRYAVI 189
+LLL A+V+ + G TPL +A +++ V++L+ +A + +Q+ L A
Sbjct: 840 QLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACS 899
Query: 190 KSNHSYCRMFLQRGADTNLGRLEDG--QTPLHLSALRDDVLCARMLYNYGADTNTRNYEG 247
K + + + L++ D NL + QTPLH++A + + L GA + G
Sbjct: 900 KGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENG 959
Query: 248 QTP 250
TP
Sbjct: 960 YTP 962
Score = 68.9 bits (167), Expect = 6e-12
Identities = 66/249 (26%), Positives = 103/249 (41%), Gaps = 40/249 (16%)
Query: 43 RDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLE 102
R+++G T L +A +G CV V + GA VKD I T +H AA +G + RL++
Sbjct: 579 RNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIG 638
Query: 103 SEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRER 162
+ + ++ + +G TPL ++ G V LL A VD G T L +
Sbjct: 639 NAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGH 698
Query: 163 SSCVKILLDHNANIDIQN-------------------GFLLRYA-------VIKSNHSYC 196
CV LL H A +++ G LL+ A NH Y
Sbjct: 699 EECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYT 758
Query: 197 RMF--LQRGADTNLGRLEDGQ----------TPLHLSALRDDVLCARMLYN-YGAD-TNT 242
+ G +T + L + + +PLH + + D+ A ML + GA N
Sbjct: 759 ALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNA 818
Query: 243 RNYEGQTPL 251
+ +G+TPL
Sbjct: 819 TDSKGRTPL 827
Score = 68.2 bits (165), Expect = 9e-12
Identities = 48/177 (27%), Positives = 86/177 (48%), Gaps = 7/177 (3%)
Query: 83 TALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAE 142
T LH AA G A I L++ S R +NAK + TPLH A + V++LL+ A+
Sbjct: 43 TPLHAAAYLGDAEIIELLILSGAR---VNAKDSKWLTPLHRAVASCSEEAVQVLLKHSAD 99
Query: 143 VDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGF---LLRYAVIKSNHSYCRMF 199
V+ TPL +A + C + L+ +N+++ + L +A + ++
Sbjct: 100 VNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLL 159
Query: 200 LQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSIS 256
L RGA+ N +D + +H +A + ++L ++GA+ ++ + TPL + S
Sbjct: 160 LSRGANINAFDKKDRRA-IHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAAS 215
Score = 55.5 bits (132), Expect = 6e-08
Identities = 38/147 (25%), Positives = 63/147 (42%), Gaps = 31/147 (21%)
Query: 105 YRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSS 164
++ + +N + N+ TPLH AA+ G + LL+ A V+ K TPL A+
Sbjct: 29 FKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEE 88
Query: 165 CVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALR 224
V++LL H+A+++ R ++ QTPLH++A
Sbjct: 89 AVQVLLKHSADVN-------------------------------ARDKNWQTPLHIAAAN 117
Query: 225 DDVLCARMLYNYGADTNTRNYEGQTPL 251
V CA L ++ N + G+T L
Sbjct: 118 KAVKCAEALVPLLSNVNVSDRAGRTAL 144
>gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [Homo
sapiens]
Length = 278
Score = 100 bits (250), Expect = 1e-21
Identities = 78/268 (29%), Positives = 137/268 (51%), Gaps = 14/268 (5%)
Query: 49 TLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSD 108
T +H +A RG+ ++ +E GA + + T LH A++ G+AR +L+L + + D
Sbjct: 21 TPVHEAAQRGESLQLQQLIESGACVN-QVTVDSITPLHAASLQGQARCVQLLLAAGAQVD 79
Query: 109 IINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKI 168
A++ DG TPL A G V+LLL + A+V+P + PL A + S CV++
Sbjct: 80 ---ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTAS-PLHEACMSGSSECVRL 135
Query: 169 LLDHNANIDIQN---GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRD 225
L+D AN++ + G L A + + ++ L GA+ N +L + T LH +A
Sbjct: 136 LIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHE--TALHHAAKVK 193
Query: 226 DVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRNLQDLCRIK 285
+V ML +G + R+ G+ P + S S ++ C ++ ++ P L LCR+
Sbjct: 194 NVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAK-CFEYYEKT---PLTLSQLCRVN 249
Query: 286 IRQCIGLQNLKLLDELPIAKVMKDYLKH 313
+R+ G++ L+ + +L I + DYL +
Sbjct: 250 LRKATGVRGLEKIAKLNIPPRLIDYLSY 277
Score = 43.5 bits (101), Expect = 2e-04
Identities = 34/120 (28%), Positives = 53/120 (44%), Gaps = 5/120 (4%)
Query: 1 MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKE 60
+L + + NP L + A +G VR +++ G + D + T LH + AR
Sbjct: 104 LLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHL 163
Query: 61 RCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP 120
CV+V L GA+ L TALH+AA + +++E I A+ N G P
Sbjct: 164 DCVKVLLNAGANVNAAKL--HETALHHAAKVKNVDLIEMLIEF---GGNIYARDNRGKKP 218
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 99.8 bits (247), Expect = 3e-21
Identities = 82/245 (33%), Positives = 114/245 (46%), Gaps = 13/245 (5%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
++AA G V +L+ G N D G T L +A G V L+HGA+ +D
Sbjct: 648 LRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHED 707
Query: 78 LIGGFTALHYAAM-----HGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSF 132
+ G TAL AA+ G A + L+++ R ++ DG TPL VAA+ G
Sbjct: 708 -VDGRTALSVAALCVPASKGHASVVSLLID---RGAEVDHCDKDGMTPLLVAAYEGHVDV 763
Query: 133 VRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNA---NIDIQNGFLLRYAVI 189
V LLLE A+VD + G TPL A +S V LL A +ID + +L A
Sbjct: 764 VDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASA 823
Query: 190 KSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQT 249
+ N R L RG D N R + G TPLH++A L L GA TN + +G+
Sbjct: 824 QGNVEVVRTLLDRGLDEN-HRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRI 882
Query: 250 PLAVS 254
P ++
Sbjct: 883 PFILA 887
Score = 94.4 bits (233), Expect = 1e-19
Identities = 75/238 (31%), Positives = 108/238 (45%), Gaps = 10/238 (4%)
Query: 21 AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
A G V V +LE G + D NG T L +A+ G V L GA D G
Sbjct: 755 AAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEG 814
Query: 81 GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
T L A+ G + R +L+ R N + + GWTPLH+AA G L+E
Sbjct: 815 R-TVLSIASAQGNVEVVRTLLD---RGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG 870
Query: 141 AEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGF----LLRYAVIKSNHSYC 196
A + + + G P LA CV+ILL++ +NID Q G+ LR A ++ +
Sbjct: 871 ARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNID-QRGYDGRNALRVAALEGHRDIV 929
Query: 197 RMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
+ GAD N + DG+ L++ AL + + A GA+ + EG+T L VS
Sbjct: 930 ELLFSHGADVNC-KDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVS 986
Score = 93.6 bits (231), Expect = 2e-19
Identities = 66/235 (28%), Positives = 114/235 (48%), Gaps = 8/235 (3%)
Query: 20 AAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLI 79
AA + G V +L G + + D+ G T+L ++A+G VR L+ G D +D
Sbjct: 787 AAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRD-D 845
Query: 80 GGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEF 139
G+T LH AA G I ++E R++ I+ NDG P +A+ G V++LLE
Sbjct: 846 AGWTPLHMAAFEGHRLICEALIEQGARTNEID---NDGRIPFILASQEGHYDCVQILLEN 902
Query: 140 KAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGF---LLRYAVIKSNHSYC 196
K+ +D G L++A + V++L H A+++ ++ L +++ +
Sbjct: 903 KSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMA 962
Query: 197 RMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
FL+ GA+ E G+T LH+S + + ++L Y AD N + E ++ L
Sbjct: 963 EYFLENGANVEASDAE-GRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSAL 1016
Score = 82.8 bits (203), Expect = 4e-16
Identities = 78/273 (28%), Positives = 118/273 (43%), Gaps = 44/273 (16%)
Query: 29 TVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD----------- 77
++R +L+ G S N D+NG TLL +A G V + + GAD ++D
Sbjct: 527 SIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAA 586
Query: 78 ----------LIG-----------GFTALHYAAMHGRARIARLMLESEYRSDIINAKSND 116
LIG G+TAL AA G + +L + + D +A S
Sbjct: 587 RQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSR- 645
Query: 117 GWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANI 176
T L AA G + V LL+ AEV+ ++G T L A V+ LLDH A +
Sbjct: 646 --TALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEV 703
Query: 177 ---DIQNGFLLRYAVI-----KSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVL 228
D+ L A + K + S + + RGA+ + +DG TPL ++A V
Sbjct: 704 NHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCD-KDGMTPLLVAAYEGHVD 762
Query: 229 CARMLYNYGADTNTRNYEGQTPLAVSISISGSS 261
+L GAD + + G+TPL + S+ +S
Sbjct: 763 VVDLLLEGGADVDHTDNNGRTPLLAAASMGHAS 795
Score = 70.5 bits (171), Expect = 2e-12
Identities = 65/272 (23%), Positives = 112/272 (41%), Gaps = 39/272 (14%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A A G+V VR +L++G N RD GWT LH +A G +E GA D
Sbjct: 818 LSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEID 877
Query: 78 LIG--------------------------------GFTALHYAAMHGRARIARLMLESEY 105
G G AL AA+ G I L+ +
Sbjct: 878 NDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFS--H 935
Query: 106 RSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSC 165
+D+ N K DG L++ A + + LE A V+ +G T L ++ +
Sbjct: 936 GADV-NCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEM 994
Query: 166 VKILLDHNANI---DIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSA 222
V++L+ ++A++ D + L+ A + + ++ ++ GA + G T L ++A
Sbjct: 995 VQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVD-HTCNQGATALCIAA 1053
Query: 223 LRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
+ ++L +GAD N + G+T + V+
Sbjct: 1054 QEGHIDVVQVLLEHGADPNHADQFGRTAMRVA 1085
Score = 67.0 bits (162), Expect = 2e-11
Identities = 55/193 (28%), Positives = 87/193 (45%), Gaps = 6/193 (3%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
++ A G V + G N +DA+G L+ A + FLE+GA+ D
Sbjct: 917 LRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASD 976
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
G TALH + G + ++++ Y +D+ NA N+ + L AA G V+LL+
Sbjct: 977 AEGR-TALHVSCWQGHMEMVQVLIA--YHADV-NAADNEKRSALQSAAWQGHVKVVQLLI 1032
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNA--NIDIQNGFLLRYAVIKSNHSY 195
E A VD ++G T L +A V++LL+H A N Q G K+ HS
Sbjct: 1033 EHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQ 1092
Query: 196 CRMFLQRGADTNL 208
L++ ++L
Sbjct: 1093 IIKLLEKYGASSL 1105
>gi|18079216 CASK interacting protein 1 [Homo sapiens]
Length = 1431
Score = 96.3 bits (238), Expect = 3e-20
Identities = 85/297 (28%), Positives = 134/297 (45%), Gaps = 34/297 (11%)
Query: 14 EELQIQAAVAAGDVHTVRKMLEQG-------------YSPNGRDANGWTLLHFSAARGKE 60
+E ++ AV A DV T +++L++ + N +D +G++ LH +A G
Sbjct: 3 KEQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNT 62
Query: 61 RCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP 120
+ + LE A +KD G LHYAA GR +L+L++ +N S++G P
Sbjct: 63 ELISLLLEAQAAVDIKD-NKGMRPLHYAAWQGRKEPMKLVLKA---GSAVNIPSDEGHIP 118
Query: 121 LHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHN------- 173
LH+AA +G +LL+ ++ + + G TPL LA R V++LL N
Sbjct: 119 LHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLE 178
Query: 174 ---ANIDIQNGFLLRYAVIKSNH-SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLC 229
+ NG + K+ H R+ LQ G D N R T LH +AL
Sbjct: 179 PRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDIN--RQTKSGTALHEAALCGKTEV 236
Query: 230 ARMLYNYGADTNTRNYEGQTPLAV--SISISGSSRPCLDFLQEVTR--QPRNLQDLC 282
R+L + G + + RN QT L + + S +SR L+E + Q R +D C
Sbjct: 237 VRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKDYC 293
>gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1
[Homo sapiens]
Length = 294
Score = 95.1 bits (235), Expect = 7e-20
Identities = 78/275 (28%), Positives = 127/275 (46%), Gaps = 15/275 (5%)
Query: 42 GRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLML 101
G + W+ +H +A G + +R + G + + LH A + G +++L
Sbjct: 31 GDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITA-DHVSPLHEACLGGHLSCVKILL 89
Query: 102 ESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRE 161
+ + +N + D TPL A G V LLL+ A V P SD + P+ A R
Sbjct: 90 KHGAQ---VNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLAS-PIHEAARRG 145
Query: 162 RSSCVKILLDHNANIDIQNGFL---LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPL 218
CV L+ + NID + L L A + + L+ GAD N G+ +D +PL
Sbjct: 146 HVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQD--SPL 203
Query: 219 HLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRNL 278
H A A +L ++GADT +N EG+ P+ + + S FL+ P +L
Sbjct: 204 HAVARTASEELACLLMDFGADTQAKNAEGKRPVEL---VPPESPLAQLFLER--EGPPSL 258
Query: 279 QDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKH 313
LCR++IR+C G+Q + +L + + +K +L H
Sbjct: 259 MQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLH 293
Score = 34.7 bits (78), Expect = 0.11
Identities = 31/123 (25%), Positives = 54/123 (43%), Gaps = 5/123 (4%)
Query: 1 MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKE 60
+L H PE I A G V V ++ G + + + ++ T L+ + +
Sbjct: 121 LLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQR 180
Query: 61 RCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP 120
CV+ LE GAD V G + LH A +A L++ ++ +D AK+ +G P
Sbjct: 181 ACVKKLLESGAD--VNQGKGQDSPLHAVARTASEELACLLM--DFGAD-TQAKNAEGKRP 235
Query: 121 LHV 123
+ +
Sbjct: 236 VEL 238
>gi|18254476 ankyrin repeat and SOCS box-containing protein 5 [Homo
sapiens]
Length = 329
Score = 94.7 bits (234), Expect = 9e-20
Identities = 82/267 (30%), Positives = 123/267 (46%), Gaps = 14/267 (5%)
Query: 51 LHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDII 110
LH +A++G+ +R L G + L T LH A + AR +LE+ +
Sbjct: 74 LHEAASQGRLLALRTLLSQGYNVNAVTL-DHVTPLHEACLGDHVACARTLLEAGAN---V 129
Query: 111 NAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL 170
NA + DG TPL A G S LLLE+ A+ L +P A + C+ IL+
Sbjct: 130 NAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQ-LESCLPSPTHEAASKGHHECLDILI 188
Query: 171 DHNANIDIQNGFLLR--YAVIKSNHSYCRM-FLQRGADTNLGRLEDGQTPLHLSALRDDV 227
++D + L Y S +C L GAD G+ D TPLH +A +
Sbjct: 189 SWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWD--TPLHAAAQQSST 246
Query: 228 LCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRNLQDLCRIKIR 287
+L +GAD N +N E P+ V+ S S R L E T P +L LCR+ IR
Sbjct: 247 EIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQ--HEAT--PSSLYQLCRLCIR 302
Query: 288 QCIGLQNLKLLDELPIAKVMKDYLKHK 314
IG L L+ +L + ++K++L+++
Sbjct: 303 SYIGKPRLHLIPQLQLPTLLKNFLQYR 329
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 94.0 bits (232), Expect = 2e-19
Identities = 61/175 (34%), Positives = 89/175 (50%), Gaps = 7/175 (4%)
Query: 83 TALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAE 142
TALH+A G I +L+ +N K + GW+PLH+AA GRD V+ LL A+
Sbjct: 42 TALHWACSAGHTEIVEFLLQLGVP---VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98
Query: 143 VDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGF---LLRYAVIKSNHSYCRMF 199
V+ ++ G TPL A + R +LL+ AN D ++ + + A K N +
Sbjct: 99 VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHIL 158
Query: 200 LQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
L A TN+ E G TPLHL+ + V A++L + GA N E +TPL V+
Sbjct: 159 LYYKASTNIQDTE-GNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
Score = 85.5 bits (210), Expect = 6e-17
Identities = 56/160 (35%), Positives = 80/160 (50%), Gaps = 4/160 (2%)
Query: 21 AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
A +AG V +L+ G N +D GW+ LH +A+ G++ V+ L GA +
Sbjct: 47 ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQ-N 105
Query: 81 GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
G T LHYAA R IA ++LE D AK + T +H AA G + +LL +K
Sbjct: 106 GCTPLHYAASKNRHEIAVMLLEGGANPD---AKDHYEATAMHRAAAKGNLKMIHILLYYK 162
Query: 141 AEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN 180
A + +G TPL LA ER K+L+ A+I I+N
Sbjct: 163 ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIEN 202
Score = 66.6 bits (161), Expect = 3e-11
Identities = 44/140 (31%), Positives = 71/140 (50%), Gaps = 4/140 (2%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A +AG V+ +L +G N + NG T LH++A++ + + LE GA+P KD
Sbjct: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
TA+H AA G ++ ++L Y N + +G TPLH+A R +LL+
Sbjct: 137 HYEA-TAMHRAAAKGNLKMIHILL---YYKASTNIQDTEGNTPLHLACDEERVEEAKLLV 192
Query: 138 EFKAEVDPLSDKGTTPLQLA 157
A + + + TPLQ+A
Sbjct: 193 SQGASIYIENKEEKTPLQVA 212
Score = 64.7 bits (156), Expect = 1e-10
Identities = 46/139 (33%), Positives = 65/139 (46%), Gaps = 4/139 (2%)
Query: 116 DGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNAN 175
D T LH A G V LL+ V+ D G +PL +A R VK LL A
Sbjct: 39 DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98
Query: 176 IDI--QNGFL-LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARM 232
++ QNG L YA K+ H M L+ GA+ + + T +H +A + ++ +
Sbjct: 99 VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD-AKDHYEATAMHRAAAKGNLKMIHI 157
Query: 233 LYNYGADTNTRNYEGQTPL 251
L Y A TN ++ EG TPL
Sbjct: 158 LLYYKASTNIQDTEGNTPL 176
Score = 30.4 bits (67), Expect = 2.2
Identities = 24/75 (32%), Positives = 35/75 (46%), Gaps = 5/75 (6%)
Query: 184 LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHL--SALRDDVLCARMLYNYGADTN 241
L +A + LQ G N + + G +PLH+ SA RD+++ + L GA N
Sbjct: 44 LHWACSAGHTEIVEFLLQLGVPVN-DKDDAGWSPLHIAASAGRDEIV--KALLGKGAQVN 100
Query: 242 TRNYEGQTPLAVSIS 256
N G TPL + S
Sbjct: 101 AVNQNGCTPLHYAAS 115
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 92.8 bits (229), Expect = 4e-19
Identities = 74/252 (29%), Positives = 123/252 (48%), Gaps = 10/252 (3%)
Query: 21 AVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIG 80
AV +G + TV +L +G S N D LH++A G +++ + GAD KD
Sbjct: 147 AVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDR-K 205
Query: 81 GFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFK 140
G+ LH AA G+ + + +L D NA N T LH+A + G+D+ L+
Sbjct: 206 GYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGN---TALHIACYLGQDAVAIELVNAG 262
Query: 141 AEVDPLSDKGTTPLQLAIIRERSS-CVKILLDHNANIDIQN---GFLLRYAVIKSNHSYC 196
A V+ +DKG TPL +A + + C+++L+++ A+++ Q+ L A I +
Sbjct: 263 ANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRS 322
Query: 197 RMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSIS 256
++ +Q G++ + + G TPLH++A L L GADT R PL +++
Sbjct: 323 QILIQNGSEIDCAD-KFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAV- 380
Query: 257 ISGSSRPCLDFL 268
+ G S C L
Sbjct: 381 LFGFSDCCRKLL 392
Score = 87.8 bits (216), Expect = 1e-17
Identities = 64/220 (29%), Positives = 109/220 (49%), Gaps = 8/220 (3%)
Query: 38 YSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIA 97
++P+ DA L S + C+ L++GADP+++D G+TA+HYAA +G +
Sbjct: 508 HTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDR-QGYTAVHYAAAYGNRQNL 566
Query: 98 RLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLA 157
L+LE + + + +S +PLH+AA+ G ++ L E +D KG T L LA
Sbjct: 567 ELLLEMSFNC-LEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLA 625
Query: 158 IIRERSSCVKILLDHNANIDI---QNGFLLRYAVIKSNHS-YCRMFLQRGADTNLGRLED 213
R + CV++L H A+ I + + +A S H+ + + G ++ + D
Sbjct: 626 TERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMD 685
Query: 214 --GQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
GQTPL L+ + V C +L G+ + + G+T L
Sbjct: 686 AYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTAL 725
Score = 87.4 bits (215), Expect = 1e-17
Identities = 68/235 (28%), Positives = 107/235 (45%), Gaps = 32/235 (13%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A+ G V V +LE+G + + D G T LH A G E C+ L+H A +D
Sbjct: 692 LMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRD 751
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSN-DGWTPLHVAAHYGRDSFVRLL 136
G T +H A+ G + R +L++ +D ++A + G++P+H A++ G + + LL
Sbjct: 752 FKGR-TPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELL 810
Query: 137 LEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYC 196
LE + L TPL A+I + S ++LL G L
Sbjct: 811 LEH-SPFSYLEGNPFTPLHCAVINNQDSTTEMLL----------GAL------------- 846
Query: 197 RMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
GA R G+TPLH +A D+V RML + A+ N ++ G+T L
Sbjct: 847 ------GAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTAL 895
Score = 80.1 bits (196), Expect = 2e-15
Identities = 70/257 (27%), Positives = 117/257 (45%), Gaps = 29/257 (11%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGAD---PT 74
+ A A+G + V+ +L G + +A G T LH + G++ + GA+ P
Sbjct: 210 LHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPN 269
Query: 75 VKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVR 134
K GFT LH AA+ + +L + +N +S +G +PLH+AA +GR + +
Sbjct: 270 DK----GFTPLHVAAVSTNGALCLELLVNNGAD--VNYQSKEGKSPLHMAAIHGRFTRSQ 323
Query: 135 LLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANI---DIQNGFLLRYAVIKS 191
+L++ +E+D G TPL +A + L+ + A+ I + F L AV+
Sbjct: 324 ILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFG 383
Query: 192 NHSYCRMFLQRG----------------ADTNLGRLED-GQTPLHLSALRDDVLCARMLY 234
CR L G A ++ ++ G+T LH +A +V C +L
Sbjct: 384 FSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLL 443
Query: 235 NYGADTNTRNYEGQTPL 251
+ GAD R+ G+TPL
Sbjct: 444 SSGADLRRRDKFGRTPL 460
Score = 80.1 bits (196), Expect = 2e-15
Identities = 66/243 (27%), Positives = 109/243 (44%), Gaps = 13/243 (5%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPN----GRDANGWTLLHFSAARGKERCVRVFLEHGADP 73
I A A G +R +L+ S + G D +G++ +H+++ G E C+ + LEH
Sbjct: 758 IHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFS 817
Query: 74 TVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFV 133
++ FT LH A ++ + ++L + + I+N++ G TPLH AA S +
Sbjct: 818 YLEG--NPFTPLHCAVINNQDSTTEMLLGA-LGAKIVNSRDAKGRTPLHAAAFADNVSGL 874
Query: 134 RLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHN----ANIDIQNGFLLRYAVI 189
R+LL+ +AEV+ G T L A +++ V+ LL +D L A
Sbjct: 875 RMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACS 934
Query: 190 KSNHSYCRMFLQRGADTNLGRLEDG--QTPLHLSALRDDVLCARMLYNYGADTNTRNYEG 247
K + M L D L + Q PLH++A + L ++GA + EG
Sbjct: 935 KGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEG 994
Query: 248 QTP 250
TP
Sbjct: 995 HTP 997
Score = 79.7 bits (195), Expect = 3e-15
Identities = 61/225 (27%), Positives = 94/225 (41%), Gaps = 6/225 (2%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A G ++ + E + + RD G T L + RG CV V HGA +K+
Sbjct: 589 LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
+T LH AA G L+++S R+DI + G TPL +A G V LLL
Sbjct: 649 RKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLL 708
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANI---DIQNGFLLRYAVIKSNHS 194
E + D +G T L + C+ LLDH+A + D + + A + +
Sbjct: 709 EKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTA 768
Query: 195 YCRMFLQRGADT---NLGRLEDGQTPLHLSALRDDVLCARMLYNY 236
R LQ T + G G +P+H ++ C +L +
Sbjct: 769 VLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH 813
Score = 78.2 bits (191), Expect = 9e-15
Identities = 63/220 (28%), Positives = 106/220 (48%), Gaps = 9/220 (4%)
Query: 39 SPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIAR 98
S N D +G + LH + G V + L GA V D LH+AA G + +
Sbjct: 132 SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKER-QPLHWAAFLGHLEVLK 190
Query: 99 LMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAI 158
L++ R + K G+ LH AA G+ V+ LL AE+D + G T L +A
Sbjct: 191 LLVA---RGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIAC 247
Query: 159 IRERSSCVKILLDHNANIDIQN--GFL-LRYAVIKSNHSYC-RMFLQRGADTNLGRLEDG 214
+ + L++ AN++ N GF L A + +N + C + + GAD N + ++G
Sbjct: 248 YLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNY-QSKEG 306
Query: 215 QTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
++PLH++A+ +++L G++ + + G TPL V+
Sbjct: 307 KSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVA 346
Score = 77.8 bits (190), Expect = 1e-14
Identities = 76/278 (27%), Positives = 123/278 (44%), Gaps = 29/278 (10%)
Query: 13 QEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGAD 72
+E + A G + ++ ++ +G +D G+ LLH +AA G+ V+ L GA+
Sbjct: 172 KERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAE 231
Query: 73 PTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSF 132
+ G TALH A G+ +A +E +N ++ G+TPLHVAA +
Sbjct: 232 IDEPNAFGN-TALHIACYLGQDAVA---IELVNAGANVNQPNDKGFTPLHVAAVSTNGAL 287
Query: 133 -VRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGF---LLRYAV 188
+ LL+ A+V+ S +G +PL +A I R + +IL+ + + ID + F L A
Sbjct: 288 CLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAA 347
Query: 189 IKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGA---------- 238
+ + GADT + D PLHL+ L C R L + G
Sbjct: 348 RYGHELLISTLMTNGADTARRGIHD-MFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSN 406
Query: 239 --------DTNTRNYEGQTPLAVSISISGSSRPCLDFL 268
D NT + G+T + + SG + CL+ L
Sbjct: 407 EHVLSAGFDINTPDNLGRT--CLHAAASGGNVECLNLL 442
Score = 76.3 bits (186), Expect = 3e-14
Identities = 68/238 (28%), Positives = 101/238 (42%), Gaps = 9/238 (3%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ A A+ + + +L N RD T LH +AA +C + V D
Sbjct: 78 LHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVAD 137
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLL 137
G +ALH+A G L+L ++ + K PLH AA G ++LL+
Sbjct: 138 R-SGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQ---PLHWAAFLGHLEVLKLLV 193
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGF---LLRYAVIKSNHS 194
A++ KG L A + VK LL A ID N F L A +
Sbjct: 194 ARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDA 253
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSAL-RDDVLCARMLYNYGADTNTRNYEGQTPL 251
+ GA+ N + G TPLH++A+ + LC +L N GAD N ++ EG++PL
Sbjct: 254 VAIELVNAGANVNQPN-DKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPL 310
Score = 67.0 bits (162), Expect = 2e-11
Identities = 70/271 (25%), Positives = 108/271 (39%), Gaps = 34/271 (12%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKD 77
+ AA + G+V + +L G RD G T LH++AA G +C + GA D
Sbjct: 427 LHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEAD 486
Query: 78 LIGGFTALHYAAMHGRARIARLMLESEYRSD-------------------------IINA 112
G + LHYAA R A S + ++ +
Sbjct: 487 -CKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSL 545
Query: 113 KSNDGWTPLHVAAHYGRDSFVRLLLE--FKAEVDPLSDKGTTPLQLAIIRERSSCVKILL 170
+ G+T +H AA YG + LLLE F D S +PL LA +K L
Sbjct: 546 RDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLA 605
Query: 171 DHNANIDIQN--GFLLRYAVIKSNHSYC-RMFLQRGADTNLGRLEDGQTPLHLSALRDDV 227
+ N+D+++ G + + + C + GA + + TPLH +A
Sbjct: 606 ETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHT 665
Query: 228 LCARMLYNYG--AD-TNTRNYEGQTPLAVSI 255
+L + G AD T+ + GQTPL ++I
Sbjct: 666 DSLHLLIDSGERADITDVMDAYGQTPLMLAI 696
Score = 63.2 bits (152), Expect = 3e-10
Identities = 51/155 (32%), Positives = 75/155 (48%), Gaps = 3/155 (1%)
Query: 18 IQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHG-ADPTVK 76
+ AA A +V +R +L+ N D G T L +A G+ V L G AD TV
Sbjct: 862 LHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVL 921
Query: 77 DLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLL 136
D TALH A G + A ++L +INA ++ PLH+AA G S V+ L
Sbjct: 922 DENKN-TALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQAL 980
Query: 137 LEFKAEVDPLSDKGTTP-LQLAIIRERSSCVKILL 170
L A V + ++G TP L A ++ + C+ ++L
Sbjct: 981 LSHGATVLAVDEEGHTPALACAPNKDVADCLALIL 1015
Score = 62.0 bits (149), Expect = 7e-10
Identities = 67/260 (25%), Positives = 105/260 (40%), Gaps = 31/260 (11%)
Query: 33 MLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHG 92
+++ G + D G T LH +A G E + + +GAD T + I LH A + G
Sbjct: 325 LIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD-TARRGIHDMFPLHLAVLFG 383
Query: 93 RARIARLMLESEYRSDIINAKSND---------------GWTPLHVAAHYGRDSFVRLLL 137
+ R +L S I+++ SN+ G T LH AA G + LLL
Sbjct: 384 FSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLL 443
Query: 138 EFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANI---DIQNGFLLRYAVIKSNHS 194
A++ G TPL A C L+ A + D + L YA +
Sbjct: 444 SSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTY- 502
Query: 195 YCRMFLQRGADTNLGRLEDGQ--TPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLA 252
R A+ + D + PL S ++ C L + GAD + R+ +G T A
Sbjct: 503 -------RRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYT--A 553
Query: 253 VSISISGSSRPCLDFLQEVT 272
V + + +R L+ L E++
Sbjct: 554 VHYAAAYGNRQNLELLLEMS 573
Score = 40.0 bits (92), Expect = 0.003
Identities = 39/174 (22%), Positives = 66/174 (37%), Gaps = 37/174 (21%)
Query: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
IN + TPLH AA+ G ++LLL A V+ TPL A + +L
Sbjct: 34 INVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLL 93
Query: 170 LDHNANIDIQNGF------------------------------------LLRYAVIKSNH 193
L H+A+++ ++ L +AV +
Sbjct: 94 LAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHL 153
Query: 194 SYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEG 247
+ L +GA N+ ++ Q PLH +A + ++L GAD ++ +G
Sbjct: 154 ETVNLLLNKGASLNVCDKKERQ-PLHWAAFLGHLEVLKLLVARGADLGCKDRKG 206
>gi|116325987 ankyrin repeat domain 42 [Homo sapiens]
Length = 389
Score = 92.4 bits (228), Expect = 5e-19
Identities = 72/285 (25%), Positives = 122/285 (42%), Gaps = 52/285 (18%)
Query: 18 IQAAVAAGDVHTVRK------MLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGA 71
I AV AGDV + + +L G GWT H +A RG++ CV+ + +GA
Sbjct: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGA 89
Query: 72 DPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDS 131
+ T +D G T LH AA HG + ++ML S + + + W P+H AA +GR
Sbjct: 90 NLTAQD-DRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKRE---WRPVHYAAFHGRLG 145
Query: 132 FVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL--------------DHNANI- 176
++LL+++ ++ + G P+ LA + C K L+ D+ N+
Sbjct: 146 CLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVL 205
Query: 177 -----------------------DIQNGFLLRY----AVIKSNHSYCRMFLQRGADTNLG 209
D+++ L + A K + + ++ G
Sbjct: 206 DLAQRFFKQNILQFIQGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININE 265
Query: 210 RLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 254
R ++G TP+H +A + + C + L GAD+N N G+ P V+
Sbjct: 266 RADNGSTPMHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVA 310
Score = 48.9 bits (115), Expect = 6e-06
Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 22/165 (13%)
Query: 85 LHYAAMHGRARIARLMLESE---------YRSDIINAKSNDGWTPLHVAAHYGRDSFVRL 135
+H+ ++H R + SE + +DI + + GWT H+AA G+D+ V+
Sbjct: 25 VHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTR-GWTASHIAAIRGQDACVQA 83
Query: 136 LLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNAN---IDIQNGFLLRYAVIKSN 192
L+ A + D+G TPL LA S ++I+L + D + + YA
Sbjct: 84 LIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGR 143
Query: 193 HSYCRMFLQRGADTNLGRLED----GQTPLHLSALRDDVLCARML 233
++ ++ G +ED G P+HL+A+ + C + L
Sbjct: 144 LGCLQLLVKWGCS-----IEDVDYNGNLPVHLAAMEGHLHCFKFL 183
>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
Length = 1202
Score = 91.7 bits (226), Expect = 8e-19
Identities = 83/284 (29%), Positives = 123/284 (43%), Gaps = 32/284 (11%)
Query: 15 ELQIQAAVAAGDVHTVRKMLEQ-------------GYSPNGRDANGWTLLHFSAARGKER 61
E + AV GDV V+K++ + + N +DA+G++ LH +A G
Sbjct: 4 EQDLILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLE 63
Query: 62 CVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPL 121
+ + LE A +KD G LHYAA GR RL+L + S +NA S DG PL
Sbjct: 64 LIALLLEAQATVDIKD-SNGMRPLHYAAWQGRLEPVRLLLRA---SAAVNAASLDGQIPL 119
Query: 122 HVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNG 181
H+AA YG +LL+ ++ ++ TPL LA R ++LL+ + + + G
Sbjct: 120 HLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEG 179
Query: 182 FL-----------LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCA 230
L A + R L+ G + N R T LH +AL
Sbjct: 180 EAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEIN--RQTKTGTALHEAALYGKTEVV 237
Query: 231 RMLYNYGADTNTRNYEGQTPLAV--SISISGSSRPCLDFLQEVT 272
R+L G D N RN QT L + + S +SR L+E +
Sbjct: 238 RLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREAS 281
Score = 42.7 bits (99), Expect = 4e-04
Identities = 48/180 (26%), Positives = 72/180 (40%), Gaps = 14/180 (7%)
Query: 110 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKIL 169
+N + DG++ LH AA G + LLLE +A VD G PL A + R V++L
Sbjct: 42 VNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLL 101
Query: 170 LDHNANID---IQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSA---- 222
L +A ++ + L A ++ M LQ ++ L + +TPL L+
Sbjct: 102 LRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVN-KAKKTPLDLACEFGR 160
Query: 223 ------LRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPR 276
L + LC +L D NY LA R L E+ RQ +
Sbjct: 161 LKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTK 220
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 90.9 bits (224), Expect = 1e-18
Identities = 77/252 (30%), Positives = 115/252 (45%), Gaps = 16/252 (6%)
Query: 21 AVAAGDVHTVRKML-EQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLI 79
AV GD V +L ++G S D+ G T H +AA+G C+RV + HG D T +D
Sbjct: 29 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 88
Query: 80 GGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEF 139
G +ALH AA + R +L+S+ ++ ++ + G T LH AA G V++L E
Sbjct: 89 -GHSALHLAAKNSHHECIRKLLQSKCPAESVD---SSGKTALHYAAAQGCLQAVQILCEH 144
Query: 140 KAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN-----GFLLRYAVIKSNHS 194
K+ ++ G PL LA+ S LLDH A+++ +N +L + SN
Sbjct: 145 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN-- 202
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARML---YNYGADTNTRNYEGQTPL 251
+++GAD NL G LH S L ++ +L + AD T Q
Sbjct: 203 AVEALIKKGADLNLVD-SLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQ 261
Query: 252 AVSISISGSSRP 263
IS S P
Sbjct: 262 VSKISSERSGTP 273
Score = 42.4 bits (98), Expect = 6e-04
Identities = 26/91 (28%), Positives = 42/91 (46%), Gaps = 1/91 (1%)
Query: 11 ELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHG 70
+L + + AV G +L+ G N R+ +G T L + G V ++ G
Sbjct: 152 DLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKG 211
Query: 71 ADPTVKDLIGGFTALHYAAMHGRARIARLML 101
AD + D + G+ ALHY+ + A I L+L
Sbjct: 212 ADLNLVDSL-GYNALHYSKLSENAGIQSLLL 241
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 90.9 bits (224), Expect = 1e-18
Identities = 77/252 (30%), Positives = 115/252 (45%), Gaps = 16/252 (6%)
Query: 21 AVAAGDVHTVRKML-EQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLI 79
AV GD V +L ++G S D+ G T H +AA+G C+RV + HG D T +D
Sbjct: 18 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 77
Query: 80 GGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEF 139
G +ALH AA + R +L+S+ ++ ++ + G T LH AA G V++L E
Sbjct: 78 -GHSALHLAAKNSHHECIRKLLQSKCPAESVD---SSGKTALHYAAAQGCLQAVQILCEH 133
Query: 140 KAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN-----GFLLRYAVIKSNHS 194
K+ ++ G PL LA+ S LLDH A+++ +N +L + SN
Sbjct: 134 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN-- 191
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARML---YNYGADTNTRNYEGQTPL 251
+++GAD NL G LH S L ++ +L + AD T Q
Sbjct: 192 AVEALIKKGADLNLVD-SLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQ 250
Query: 252 AVSISISGSSRP 263
IS S P
Sbjct: 251 VSKISSERSGTP 262
Score = 42.4 bits (98), Expect = 6e-04
Identities = 26/91 (28%), Positives = 42/91 (46%), Gaps = 1/91 (1%)
Query: 11 ELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHG 70
+L + + AV G +L+ G N R+ +G T L + G V ++ G
Sbjct: 141 DLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKG 200
Query: 71 ADPTVKDLIGGFTALHYAAMHGRARIARLML 101
AD + D + G+ ALHY+ + A I L+L
Sbjct: 201 ADLNLVDSL-GYNALHYSKLSENAGIQSLLL 230
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 90.9 bits (224), Expect = 1e-18
Identities = 77/252 (30%), Positives = 115/252 (45%), Gaps = 16/252 (6%)
Query: 21 AVAAGDVHTVRKML-EQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLI 79
AV GD V +L ++G S D+ G T H +AA+G C+RV + HG D T +D
Sbjct: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 85
Query: 80 GGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEF 139
G +ALH AA + R +L+S+ ++ ++ + G T LH AA G V++L E
Sbjct: 86 -GHSALHLAAKNSHHECIRKLLQSKCPAESVD---SSGKTALHYAAAQGCLQAVQILCEH 141
Query: 140 KAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN-----GFLLRYAVIKSNHS 194
K+ ++ G PL LA+ S LLDH A+++ +N +L + SN
Sbjct: 142 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN-- 199
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARML---YNYGADTNTRNYEGQTPL 251
+++GAD NL G LH S L ++ +L + AD T Q
Sbjct: 200 AVEALIKKGADLNLVD-SLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQ 258
Query: 252 AVSISISGSSRP 263
IS S P
Sbjct: 259 VSKISSERSGTP 270
Score = 42.4 bits (98), Expect = 6e-04
Identities = 26/91 (28%), Positives = 42/91 (46%), Gaps = 1/91 (1%)
Query: 11 ELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHG 70
+L + + AV G +L+ G N R+ +G T L + G V ++ G
Sbjct: 149 DLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKG 208
Query: 71 ADPTVKDLIGGFTALHYAAMHGRARIARLML 101
AD + D + G+ ALHY+ + A I L+L
Sbjct: 209 ADLNLVDSL-GYNALHYSKLSENAGIQSLLL 238
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 90.9 bits (224), Expect = 1e-18
Identities = 77/252 (30%), Positives = 115/252 (45%), Gaps = 16/252 (6%)
Query: 21 AVAAGDVHTVRKML-EQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLI 79
AV GD V +L ++G S D+ G T H +AA+G C+RV + HG D T +D
Sbjct: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 85
Query: 80 GGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEF 139
G +ALH AA + R +L+S+ ++ ++ + G T LH AA G V++L E
Sbjct: 86 -GHSALHLAAKNSHHECIRKLLQSKCPAESVD---SSGKTALHYAAAQGCLQAVQILCEH 141
Query: 140 KAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN-----GFLLRYAVIKSNHS 194
K+ ++ G PL LA+ S LLDH A+++ +N +L + SN
Sbjct: 142 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN-- 199
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARML---YNYGADTNTRNYEGQTPL 251
+++GAD NL G LH S L ++ +L + AD T Q
Sbjct: 200 AVEALIKKGADLNLVD-SLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQ 258
Query: 252 AVSISISGSSRP 263
IS S P
Sbjct: 259 VSKISSERSGTP 270
Score = 42.4 bits (98), Expect = 6e-04
Identities = 26/91 (28%), Positives = 42/91 (46%), Gaps = 1/91 (1%)
Query: 11 ELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHG 70
+L + + AV G +L+ G N R+ +G T L + G V ++ G
Sbjct: 149 DLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKG 208
Query: 71 ADPTVKDLIGGFTALHYAAMHGRARIARLML 101
AD + D + G+ ALHY+ + A I L+L
Sbjct: 209 ADLNLVDSL-GYNALHYSKLSENAGIQSLLL 238
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 90.9 bits (224), Expect = 1e-18
Identities = 77/252 (30%), Positives = 115/252 (45%), Gaps = 16/252 (6%)
Query: 21 AVAAGDVHTVRKML-EQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLI 79
AV GD V +L ++G S D+ G T H +AA+G C+RV + HG D T +D
Sbjct: 26 AVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTT 85
Query: 80 GGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEF 139
G +ALH AA + R +L+S+ ++ ++ + G T LH AA G V++L E
Sbjct: 86 -GHSALHLAAKNSHHECIRKLLQSKCPAESVD---SSGKTALHYAAAQGCLQAVQILCEH 141
Query: 140 KAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN-----GFLLRYAVIKSNHS 194
K+ ++ G PL LA+ S LLDH A+++ +N +L + SN
Sbjct: 142 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSN-- 199
Query: 195 YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARML---YNYGADTNTRNYEGQTPL 251
+++GAD NL G LH S L ++ +L + AD T Q
Sbjct: 200 AVEALIKKGADLNLVD-SLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQ 258
Query: 252 AVSISISGSSRP 263
IS S P
Sbjct: 259 VSKISSERSGTP 270
Score = 42.4 bits (98), Expect = 6e-04
Identities = 26/91 (28%), Positives = 42/91 (46%), Gaps = 1/91 (1%)
Query: 11 ELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHG 70
+L + + AV G +L+ G N R+ +G T L + G V ++ G
Sbjct: 149 DLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKG 208
Query: 71 ADPTVKDLIGGFTALHYAAMHGRARIARLML 101
AD + D + G+ ALHY+ + A I L+L
Sbjct: 209 ADLNLVDSL-GYNALHYSKLSENAGIQSLLL 238
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 90.9 bits (224), Expect = 1e-18
Identities = 77/231 (33%), Positives = 115/231 (49%), Gaps = 14/231 (6%)
Query: 27 VHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDL--IGGFTA 84
VH + + + G P+ D+ G T LH++A V+VFL+H P+VKD + G T+
Sbjct: 271 VHLLLERNKSGTIPS--DSQGATPLHYAAQSNFAETVKVFLKH---PSVKDDSDLEGRTS 325
Query: 85 LHYAAMHGRARIARLMLESEYRSDI-INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEV 143
+AA G + R ML +SDI IN G T LH AA G S V+LLLE A+V
Sbjct: 326 FMWAAGKGSDDVLRTMLS--LKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQV 383
Query: 144 DPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDI--QNGF-LLRYAVIKSNHSYCRMFL 200
D TPL A ++ L+ A +D+ Q+G LL +A + N C++ +
Sbjct: 384 DATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILI 443
Query: 201 QRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 251
+ + N+ G+TPL +A + C +L AD N ++ EG+T L
Sbjct: 444 ENKINPNVQDYA-GRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTAL 493
Score = 77.4 bits (189), Expect = 2e-14
Identities = 68/237 (28%), Positives = 110/237 (46%), Gaps = 12/237 (5%)
Query: 49 TLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSD 108
T LH++A G + V + LE T+ G T LHYAA A ++ L+
Sbjct: 257 TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLK---HPS 313
Query: 109 IINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVD-PLSDK-GTTPLQLAIIRERSSCV 166
+ + +G T AA G D +R +L K+++D ++DK G T L A + S V
Sbjct: 314 VKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTV 373
Query: 167 KILLDHNANI---DIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSAL 223
K+LL++NA + D+ L A + + ++ GA +L +DG + LH +AL
Sbjct: 374 KLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVD-QDGHSLLHWAAL 432
Query: 224 RDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRNLQD 280
+ ++L + N ++Y G+TPL + G C+ L E P N+QD
Sbjct: 433 GGNADVCQILIENKINPNVQDYAGRTPL--QCAAYGGYINCMAVLMENNADP-NIQD 486
Score = 62.0 bits (149), Expect = 7e-10
Identities = 68/290 (23%), Positives = 117/290 (40%), Gaps = 42/290 (14%)
Query: 3 HHHCRRNPELQEELQIQAAVAAGDVHTVRKML--EQGYSPNGRDANGWTLLHFSAARGKE 60
H + + +L+ A G +R ML + N D G T LH +A G
Sbjct: 311 HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHV 370
Query: 61 RCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTP 120
V++ LE+ A D++ T L A G + + +++ R D+++ DG +
Sbjct: 371 STVKLLLENNAQVDATDVMK-HTPLFRACEMGHKDVIQTLIKGGARVDLVD---QDGHSL 426
Query: 121 LHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN 180
LH AA G ++L+E K + G TPLQ A +C+ +L+++NA+ +IQ+
Sbjct: 427 LHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQD 486
Query: 181 GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADT 240
++G+T LH S + ++L ++ A
Sbjct: 487 -------------------------------KEGRTALHWSCNNGYLDAIKLLLDFAAFP 515
Query: 241 N--TRNYEGQTPLAVSISISGSSRPCLDF-LQEVTRQPRNLQDLCRIKIR 287
N N E TPL ++ G + F L+ +QD+ KI+
Sbjct: 516 NQMENNEERYTPL--DYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQ 563
Score = 50.1 bits (118), Expect = 3e-06
Identities = 53/218 (24%), Positives = 97/218 (44%), Gaps = 17/218 (7%)
Query: 51 LHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDII 110
+H +A G + ++ + + K+ G T L Y + R A +L++ +
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKA---GADV 74
Query: 111 NAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL 170
N + T LH+AA G F++LLL +A + TPL L C+ +LL
Sbjct: 75 NKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL 134
Query: 171 DHNA--NIDIQN---GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLE-DGQTPLHLSALR 224
A +D Q+ L ++ +N + ++ ++ D+N+G + +G+ PLH +A
Sbjct: 135 KFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKH--DSNIGIPDVEGKIPLHWAANH 192
Query: 225 DD------VLCARMLYNYGADTNTRNYEGQTPLAVSIS 256
D V C + N ++YEG+TPL +++
Sbjct: 193 KDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVA 230
Score = 47.8 bits (112), Expect = 1e-05
Identities = 53/260 (20%), Positives = 100/260 (38%), Gaps = 45/260 (17%)
Query: 33 MLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHG 92
+L+ G N D + T LH +A +G R +++ L A+ KDL T LH H
Sbjct: 67 LLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDL-EEMTPLHLTTRHR 125
Query: 93 RARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEV--------- 143
+ L+L+ + ++ + + T LH +A+Y V+LL++ + +
Sbjct: 126 SPKCLALLLKFMAPGE-VDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKI 184
Query: 144 ---------DPLS---------------------DKGTTPLQLAIIRERSSCVKILLDH- 172
DP + +G TPL A+ + V +L +
Sbjct: 185 PLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYE 244
Query: 173 NANIDIQNGFL---LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLC 229
+ NI + L +A + + + L+R + G TPLH +A +
Sbjct: 245 SCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAET 304
Query: 230 ARMLYNYGADTNTRNYEGQT 249
++ + + + + EG+T
Sbjct: 305 VKVFLKHPSVKDDSDLEGRT 324
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,815,444
Number of Sequences: 37866
Number of extensions: 510795
Number of successful extensions: 5562
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 353
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 1025
Number of HSP's gapped (non-prelim): 1847
length of query: 318
length of database: 18,247,518
effective HSP length: 102
effective length of query: 216
effective length of database: 14,385,186
effective search space: 3107200176
effective search space used: 3107200176
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.