Search of human proteins with 37588853

Search of human proteins with 37588853

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|37588853 vasoactive intestinal peptide isoform 2
preproprotein [Homo sapiens]
         (169 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|37588853 vasoactive intestinal peptide isoform 2 preproprotei...   334   2e-92
gi|4507897 vasoactive intestinal peptide isoform 1 preproprotein...   330   5e-91
gi|153266792 adenylate cyclase activating polypeptide precursor ...    69   3e-12
gi|153266795 adenylate cyclase activating polypeptide precursor ...    69   3e-12
gi|4503945 glucagon preproprotein [Homo sapiens]                       50   9e-07
gi|11034841 growth hormone releasing hormone preproprotein [Homo...    43   1e-04
gi|11345450 secretin preproprotein [Homo sapiens]                      35   0.040
gi|8923911 LanC lantibiotic synthetase component C-like 2 [Homo ...    30   0.99 
gi|154354990 ankyrin repeat domain 26 [Homo sapiens]                   30   1.3  
gi|23308597 adenomatosis polyposis coli down-regulated 1 [Homo s...    28   4.9  
gi|110349721 titin isoform novex-3 [Homo sapiens]                      27   6.4  
gi|122891870 melanoma inhibitory activity family, member 3 [Homo...    27   8.4  
gi|22202611 carboxypeptidase D precursor [Homo sapiens]                27   8.4  
gi|13124883 HsKin17 protein [Homo sapiens]                             27   8.4  

>gi|37588853 vasoactive intestinal peptide isoform 2 preproprotein
           [Homo sapiens]
          Length = 169

 Score =  334 bits (857), Expect = 2e-92
 Identities = 169/169 (100%), Positives = 169/169 (100%)

Query: 1   MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM 60
           MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM
Sbjct: 1   MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM 60

Query: 61  LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSNISEDPVP 120
           LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSNISEDPVP
Sbjct: 61  LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSNISEDPVP 120

Query: 121 VKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK 169
           VKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK
Sbjct: 121 VKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK 169


>gi|4507897 vasoactive intestinal peptide isoform 1 preproprotein
           [Homo sapiens]
          Length = 170

 Score =  330 bits (845), Expect = 5e-91
 Identities = 169/170 (99%), Positives = 169/170 (99%), Gaps = 1/170 (0%)

Query: 1   MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM 60
           MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM
Sbjct: 1   MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDM 60

Query: 61  LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRV-SNISEDPV 119
           LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRV SNISEDPV
Sbjct: 61  LQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSSNISEDPV 120

Query: 120 PVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK 169
           PVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK
Sbjct: 121 PVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK 170


>gi|153266792 adenylate cyclase activating polypeptide precursor
           [Homo sapiens]
          Length = 176

 Score = 68.6 bits (166), Expect = 3e-12
 Identities = 39/79 (49%), Positives = 53/79 (67%), Gaps = 7/79 (8%)

Query: 82  ADGVFTSDFSKLLGQLSAKKYLESLMGKRVSN-----ISEDPVPV-KRHSDAVFTDNYTR 135
           A G+    + K+L QLSA K+L+SL+ + V         +D  P+ KRHSD +FTD+Y+R
Sbjct: 84  AHGILNEAYRKVLDQLSAGKHLQSLVARGVGGSLGGGAGDDAEPLSKRHSDGIFTDSYSR 143

Query: 136 LRKQMAVKKYLNSILNGKR 154
            RKQMAVKKYL ++L GKR
Sbjct: 144 YRKQMAVKKYLAAVL-GKR 161



 Score = 40.0 bits (92), Expect = 0.001
 Identities = 15/31 (48%), Positives = 24/31 (77%)

Query: 80  RHADGVFTSDFSKLLGQLSAKKYLESLMGKR 110
           RH+DG+FT  +S+   Q++ KKYL +++GKR
Sbjct: 131 RHSDGIFTDSYSRYRKQMAVKKYLAAVLGKR 161


>gi|153266795 adenylate cyclase activating polypeptide precursor
           [Homo sapiens]
          Length = 176

 Score = 68.6 bits (166), Expect = 3e-12
 Identities = 39/79 (49%), Positives = 53/79 (67%), Gaps = 7/79 (8%)

Query: 82  ADGVFTSDFSKLLGQLSAKKYLESLMGKRVSN-----ISEDPVPV-KRHSDAVFTDNYTR 135
           A G+    + K+L QLSA K+L+SL+ + V         +D  P+ KRHSD +FTD+Y+R
Sbjct: 84  AHGILNEAYRKVLDQLSAGKHLQSLVARGVGGSLGGGAGDDAEPLSKRHSDGIFTDSYSR 143

Query: 136 LRKQMAVKKYLNSILNGKR 154
            RKQMAVKKYL ++L GKR
Sbjct: 144 YRKQMAVKKYLAAVL-GKR 161



 Score = 40.0 bits (92), Expect = 0.001
 Identities = 15/31 (48%), Positives = 24/31 (77%)

Query: 80  RHADGVFTSDFSKLLGQLSAKKYLESLMGKR 110
           RH+DG+FT  +S+   Q++ KKYL +++GKR
Sbjct: 131 RHSDGIFTDSYSRYRKQMAVKKYLAAVLGKR 161


>gi|4503945 glucagon preproprotein [Homo sapiens]
          Length = 180

 Score = 50.1 bits (118), Expect = 9e-07
 Identities = 33/122 (27%), Positives = 64/122 (52%), Gaps = 10/122 (8%)

Query: 51  QVSLKEDIDMLQNALAENDTPYYD---VSRNARHADGVFTSDFSKLLGQLSAKKYLESLM 107
           Q SL++  +  ++  A    P  D   ++ + RH+ G FTSD+SK L    A+ +++ LM
Sbjct: 20  QRSLQDTEEKSRSFSASQADPLSDPDQMNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLM 79

Query: 108 G--KRVSNISEDPVPVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPE 165
              +  +NI++     +RH++  FT + +   +  A K+++  ++ G+        DFPE
Sbjct: 80  NTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRR-----DFPE 134

Query: 166 EL 167
           E+
Sbjct: 135 EV 136



 Score = 42.0 bits (97), Expect = 3e-04
 Identities = 23/79 (29%), Positives = 41/79 (51%), Gaps = 5/79 (6%)

Query: 80  RHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSNISEDPVPV-----KRHSDAVFTDNYT 134
           RHA+G FTSD S  L   +AK+++  L+  R      + V +     +RH+D  F+D   
Sbjct: 97  RHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVAIVEELGRRHADGSFSDEMN 156

Query: 135 RLRKQMAVKKYLNSILNGK 153
            +   +A + ++N ++  K
Sbjct: 157 TILDNLAARDFINWLIQTK 175



 Score = 28.5 bits (62), Expect = 2.9
 Identities = 10/34 (29%), Positives = 23/34 (67%)

Query: 80  RHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSN 113
           RHADG F+ + + +L  L+A+ ++  L+  ++++
Sbjct: 145 RHADGSFSDEMNTILDNLAARDFINWLIQTKITD 178


>gi|11034841 growth hormone releasing hormone preproprotein [Homo
           sapiens]
          Length = 108

 Score = 43.1 bits (100), Expect = 1e-04
 Identities = 27/83 (32%), Positives = 48/83 (57%), Gaps = 3/83 (3%)

Query: 77  RNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSNISEDPVPVKRHSDAVFTDNYTRL 136
           R  R+AD +FT+ + K+LGQLSA+K L+ +M ++    +++     R    V  D+    
Sbjct: 28  RMRRYADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARLGRQV--DSMWAE 85

Query: 137 RKQMAVKKYLNSIL-NGKRSSEG 158
           +KQM ++  L ++L    R+S+G
Sbjct: 86  QKQMELESILVALLQKHSRNSQG 108



 Score = 31.2 bits (69), Expect = 0.44
 Identities = 10/39 (25%), Positives = 27/39 (69%)

Query: 121 VKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGE 159
           ++R++DA+FT++Y ++  Q++ +K L  I++ ++    +
Sbjct: 29  MRRYADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQ 67


>gi|11345450 secretin preproprotein [Homo sapiens]
          Length = 121

 Score = 34.7 bits (78), Expect = 0.040
 Identities = 18/49 (36%), Positives = 28/49 (57%)

Query: 77  RNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSNISEDPVPVKRHS 125
           R  RH+DG FTS+ S+L      ++ L+ L+GKR    +E+ +   R S
Sbjct: 24  RARRHSDGTFTSELSRLREGARLQRLLQGLVGKRSEQDAENSMAWTRLS 72



 Score = 31.6 bits (70), Expect = 0.34
 Identities = 15/40 (37%), Positives = 24/40 (60%), Gaps = 1/40 (2%)

Query: 118 PVPVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSE 157
           P   +RHSD  FT   +RLR+   +++ L  ++ GKRS +
Sbjct: 22  PPRARRHSDGTFTSELSRLREGARLQRLLQGLV-GKRSEQ 60


>gi|8923911 LanC lantibiotic synthetase component C-like 2 [Homo
           sapiens]
          Length = 450

 Score = 30.0 bits (66), Expect = 0.99
 Identities = 25/82 (30%), Positives = 40/82 (48%), Gaps = 6/82 (7%)

Query: 87  TSDFSKLLGQLS-AKKYLESLMGKRVSNISEDPVPVKRHSDAVFTDNYTRLRKQMAVKKY 145
           T D + LL  L   K+ L +L G+RV+ +  D  P+     AV    Y +LR     ++ 
Sbjct: 120 TCDQTYLLRSLDYVKRTLRNLNGRRVTFLCGDAGPL-----AVGAVIYHKLRSDCESQEC 174

Query: 146 LNSILNGKRSSEGESPDFPEEL 167
           +  +L  +RS   +  D P+EL
Sbjct: 175 VTKLLQLQRSVVCQESDLPDEL 196


>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
          Length = 1710

 Score = 29.6 bits (65), Expect = 1.3
 Identities = 23/122 (18%), Positives = 54/122 (44%), Gaps = 11/122 (9%)

Query: 50   DQVSLKEDIDMLQNALAENDTPYYDVSRNARHADGVFTSDFSKLL---------GQLSAK 100
            + +S +++I+M Q  +   ++  ++  ++  H + +   + + L           Q   K
Sbjct: 881  NHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEK 940

Query: 101  KYLESLMGKRVSNISEDPVPVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGES 160
            K  E L  K V   +ED     + ++   T   ++   +++V    N++LN K  +E +S
Sbjct: 941  KCFEDL--KIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQS 998

Query: 161  PD 162
             +
Sbjct: 999  KE 1000


>gi|23308597 adenomatosis polyposis coli down-regulated 1 [Homo
           sapiens]
          Length = 514

 Score = 27.7 bits (60), Expect = 4.9
 Identities = 14/29 (48%), Positives = 20/29 (68%), Gaps = 2/29 (6%)

Query: 138 KQMAVKKYLNSILNGKRSSEGESPDFPEE 166
           +Q A  +YL  + NG+R S+G SPD PE+
Sbjct: 428 EQDARGRYL--LFNGQRPSDGSSPDRPEK 454


>gi|110349721 titin isoform novex-3 [Homo sapiens]
          Length = 5604

 Score = 27.3 bits (59), Expect = 6.4
 Identities = 26/114 (22%), Positives = 48/114 (42%), Gaps = 15/114 (13%)

Query: 69   DTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYL-----ESLMGKRVSNISE------- 116
            DT   +++      +G +T   S  +GQ+S+   L     ES++ +R+    E       
Sbjct: 3397 DTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKELF 3456

Query: 117  ---DPVPVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEEL 167
               +    +R +   F+D+     K MA K+Y + I +     E   P F ++L
Sbjct: 3457 SEGESEHSERDTRDAFSDSEDIDHKSMAAKRYASRISSTSSWPEYFKPSFTQKL 3510


>gi|122891870 melanoma inhibitory activity family, member 3 [Homo
           sapiens]
          Length = 1907

 Score = 26.9 bits (58), Expect = 8.4
 Identities = 14/50 (28%), Positives = 28/50 (56%), Gaps = 3/50 (6%)

Query: 117 DPVPVKRHS---DAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDF 163
           +P PV+ +S   D+VF++N   L++Q   +K+ +   +    ++GE   F
Sbjct: 178 EPEPVEANSEESDSVFSENTEDLQEQFTTQKHHSHANSQANHAQGEQASF 227


>gi|22202611 carboxypeptidase D precursor [Homo sapiens]
          Length = 1380

 Score = 26.9 bits (58), Expect = 8.4
 Identities = 15/40 (37%), Positives = 22/40 (55%)

Query: 76  SRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSNIS 115
           S +   A    T +F  L+  LSA+  LESLM +  SN++
Sbjct: 888 SSSTNDASDPTTKEFETLIKDLSAENGLESLMLRSSSNLA 927


>gi|13124883 HsKin17 protein [Homo sapiens]
          Length = 393

 Score = 26.9 bits (58), Expect = 8.4
 Identities = 19/78 (24%), Positives = 30/78 (38%)

Query: 88  SDFSKLLGQLSAKKYLESLMGKRVSNISEDPVPVKRHSDAVFTDNYTRLRKQMAVKKYLN 147
           +DF+K LG+    K  E+  G  +  I  DP  ++R  +           ++   K    
Sbjct: 116 TDFTKWLGREGLCKVDETPKGWYIQYIDRDPETIRRQLELEKKKKQDLDDEEKTAKFIEE 175

Query: 148 SILNGKRSSEGESPDFPE 165
            +  G    E E P F E
Sbjct: 176 QVRRGLEGKEQEVPTFTE 193


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.131    0.364 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,813,383
Number of Sequences: 37866
Number of extensions: 223197
Number of successful extensions: 485
Number of sequences better than 10.0: 14
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 459
Number of HSP's gapped (non-prelim): 21
length of query: 169
length of database: 18,247,518
effective HSP length: 95
effective length of query: 74
effective length of database: 14,650,248
effective search space: 1084118352
effective search space used: 1084118352
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 58 (26.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.