Search of human proteins with 34878777

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|34878777 ring finger protein 20 [Homo sapiens]
         (975 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|34878777 ring finger protein 20 [Homo sapiens]                    1882   0.0  
gi|7662230 ring finger protein 40 [Homo sapiens]                     1072   0.0  
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            139   1e-32
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   132   2e-30
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   132   2e-30
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   132   2e-30
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   132   2e-30
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...   126   1e-28
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       125   3e-28
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       125   3e-28
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        125   3e-28
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        125   3e-28
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        125   3e-28
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        125   3e-28
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        125   3e-28
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        125   3e-28
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...   123   7e-28
gi|55770834 centromere protein F [Homo sapiens]                       123   7e-28
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...   123   1e-27
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...   123   1e-27
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...   122   2e-27
gi|38044112 restin isoform b [Homo sapiens]                           121   4e-27
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...   121   4e-27
gi|148746195 trichohyalin [Homo sapiens]                              119   1e-26
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    119   2e-26
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   118   3e-26
gi|4506751 restin isoform a [Homo sapiens]                            117   4e-26
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    116   9e-26
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...   115   2e-25
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   115   3e-25

>gi|34878777 ring finger protein 20 [Homo sapiens]
          Length = 975

 Score = 1882 bits (4876), Expect = 0.0
 Identities = 975/975 (100%), Positives = 975/975 (100%)

Query: 1   MSGIGNKRAAGEPGTSMPPEKKAAVEDSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAE 60
           MSGIGNKRAAGEPGTSMPPEKKAAVEDSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAE
Sbjct: 1   MSGIGNKRAAGEPGTSMPPEKKAAVEDSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAE 60

Query: 61  MLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDENIRIILKRYDLEQGLGDL 120
           MLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDENIRIILKRYDLEQGLGDL
Sbjct: 61  MLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDENIRIILKRYDLEQGLGDL 120

Query: 121 LTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSSSEEMESQLQERVES 180
           LTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSSSEEMESQLQERVES
Sbjct: 121 LTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSSSEEMESQLQERVES 180

Query: 181 SRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQ 240
           SRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQ
Sbjct: 181 SRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQ 240

Query: 241 EKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVN 300
           EKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVN
Sbjct: 241 EKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVN 300

Query: 301 SKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDFEEVTTQN 360
           SKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDFEEVTTQN
Sbjct: 301 SKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDFEEVTTQN 360

Query: 361 EKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQV 420
           EKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQV
Sbjct: 361 EKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQV 420

Query: 421 ELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLI 480
           ELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLI
Sbjct: 421 ELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLI 480

Query: 481 SSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDS 540
           SSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDS
Sbjct: 481 SSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDS 540

Query: 541 EDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKES 600
           EDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKES
Sbjct: 541 EDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKES 600

Query: 601 EKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDK 660
           EKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDK
Sbjct: 601 EKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDK 660

Query: 661 VQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAM 720
           VQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAM
Sbjct: 661 VQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAM 720

Query: 721 AKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEE 780
           AKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEE
Sbjct: 721 AKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEE 780

Query: 781 KEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEA 840
           KEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEA
Sbjct: 781 KEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEA 840

Query: 841 AQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKKPD 900
           AQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKKPD
Sbjct: 841 AQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKKPD 900

Query: 901 NVPKCDEILMEEIKDYKARLTCPCCNMRKKDAVLTKCFHVFCFECVKTRYDTRQRKCPKC 960
           NVPKCDEILMEEIKDYKARLTCPCCNMRKKDAVLTKCFHVFCFECVKTRYDTRQRKCPKC
Sbjct: 901 NVPKCDEILMEEIKDYKARLTCPCCNMRKKDAVLTKCFHVFCFECVKTRYDTRQRKCPKC 960

Query: 961 NAAFGANDFHRIYIG 975
           NAAFGANDFHRIYIG
Sbjct: 961 NAAFGANDFHRIYIG 975


>gi|7662230 ring finger protein 40 [Homo sapiens]
          Length = 1001

 Score = 1072 bits (2773), Expect = 0.0
 Identities = 588/1010 (58%), Positives = 745/1010 (73%), Gaps = 46/1010 (4%)

Query: 1    MSGIGNKRAAGEPGTSMPPEKKAAVEDSGTT--VETIKLGGVSSTEELDIRTLQTKNRKL 58
            MSG GNKRAAG+ G+  PPEKK + E+  TT  +E I+LGG+SSTEE+D++ LQ KN+KL
Sbjct: 1    MSGPGNKRAAGDGGSG-PPEKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKL 59

Query: 59   AEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDENIRIILKRYDLEQGLG 118
            AE L+QRQA EDELRE IEKLE+RQATDDA+LLIVNRYW+Q DE +  +L+ ++ +   G
Sbjct: 60   AERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQ---G 116

Query: 119  DLLTERKALVVPE---------PEPDSDSNQERKDDRERGEGQEPAFSFLATLASSSSEE 169
            +L +  +A    E         PEP +   ++    + R    EPA +F+  L +SSSEE
Sbjct: 117  ELSSAPEAPGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEE 176

Query: 170  MESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNS-GDNLIVEEAVQELNSFLAQE 228
            +E +LQ R+E S+ AVS++V   D+LQ +VE L +++ S GD+  + EA Q     L +E
Sbjct: 177  VELELQGRMEFSKAAVSRVVEASDRLQRRVEELCQRVYSRGDSEPLSEAAQAHTRELGRE 236

Query: 229  NMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRL 288
            N RLQ+L   LQEKH  +S E+S+LQ KV +AE++V  +E+ ++DLQWDI+K+RKREQ+L
Sbjct: 237  NRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIEKLRKREQKL 296

Query: 289  NRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEK 348
            N+HLAE LE++NS GY V G+ S   GG IT++ +KFE +NAELEEN+ELA +R+ ELEK
Sbjct: 297  NKHLAEALEQLNS-GYYVSGSSSGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEK 355

Query: 349  LRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTL 408
            L+ + +     NE+LKV LRS  E+VV+ET EYR +Q+QFS+LYNESLQ+K  LDEAR L
Sbjct: 356  LQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGL 415

Query: 409  LHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQ 468
            L  T+ +H   +E +E DE+ L KKLRTEVIQLEDTLAQVRKEYEMLRIEFEQ LAANEQ
Sbjct: 416  LLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQ 475

Query: 469  AGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLR-SGSALLQSQSSTE 527
            AGPINREMRHLISSLQNHNHQLKG+  RYKRKLRE Q+++ K R + SGSA   S  +  
Sbjct: 476  AGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSA--HSTPNLG 533

Query: 528  DPKDE----PAELK----------PDSEDLSSQSSASKASQEDANEIKSKRDEEERERER 573
             P+D     PA  K          PD+    +    +  +     + +    EE+ +   
Sbjct: 534  HPEDSGVSAPAPGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTSVKKEELVPSEEDFQGIT 593

Query: 574  REKEREREREREKEKEREREKQKLKESE---------KERDSAKDKEKGKHDDGRKKEAE 624
               +    R RE E    R K++L+E E             S  D+EK K ++ ++KE+E
Sbjct: 594  PGAQGPSSRGREPEA---RPKRELREREGPSLGPPPVASALSRADREKAKVEETKRKESE 650

Query: 625  IIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDL 684
            ++K L+ ELKKAQESQKEMKLLLDMY+SAPKEQRDKVQLMAAE+K+KAE+++LR R+++L
Sbjct: 651  LLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIREL 710

Query: 685  EDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQE 744
            E+++++E+KK+ADEDALR+IR  EEQIE+LQ+KL   KQEEEALLSEMDVTGQAFEDMQE
Sbjct: 711  EERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQE 770

Query: 745  QNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRK 804
            QN RL+QQLREKDDANFKLMSERIK+NQIHKLL+EEK+EL +QVL LK+QVDAQL  V+K
Sbjct: 771  QNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQK 830

Query: 805  LEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDE 864
            LEEKE  LQ ++G  EKEL LR+QALE+NKRKA+EAAQLA+DLK QLE  Q +L + Q  
Sbjct: 831  LEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPC 890

Query: 865  IVENSVTKEKDMFNFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDYKARLTCPC 924
            + E+   +EK+ FN KRAQEDISRLRRKLE  +K +     DEIL EEIK+YKARLTCPC
Sbjct: 891  LAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKEYKARLTCPC 950

Query: 925  CNMRKKDAVLTKCFHVFCFECVKTRYDTRQRKCPKCNAAFGANDFHRIYI 974
            CN RKKDAVLTKCFHVFCFECV+ RY+ RQRKCPKCNAAFGA+DFHRIYI
Sbjct: 951  CNTRKKDAVLTKCFHVFCFECVRGRYEARQRKCPKCNAAFGAHDFHRIYI 1000


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  139 bits (351), Expect = 1e-32
 Identities = 205/987 (20%), Positives = 432/987 (43%), Gaps = 97/987 (9%)

Query: 44   EELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDEN 103
            +E  +  LQ K  +L E L ++     EL+  ++K +++     A          +   +
Sbjct: 451  KEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQND 510

Query: 104  IRIILKRY-DLEQGLGDLLTERKALVVPEPEPDSDSNQERKD---DRERGEGQEPAFSFL 159
            +  +L++  D +Q + +L    +AL+    E  S   +ER+D     + GEG+    + L
Sbjct: 511  LEQVLRQIGDKDQKIQNL----EALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQL 566

Query: 160  ATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDN--LIVEEA 217
                + + +E  +QL E++++   +  Q     + L ++V+     L +  +  L +E +
Sbjct: 567  QE-KNHTLQEQVTQLTEKLKNQSESHKQ---AQENLHDQVQEQKAHLRAAQDRVLSLETS 622

Query: 218  VQELNSFLAQENMRLQEL-------TDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESM 270
            V ELNS L +   ++ +L       T+LL       + + + LQ+ ++TA++ +   +  
Sbjct: 623  VNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 682

Query: 271  IDDLQWDIDKIRKREQ-------RLNRHLAEVLER---VNSKGYKVYGAGSSLYGGTITI 320
            ++ +   +D++  + Q       +L  HL E  E+   +  K  ++ G    L   ++ +
Sbjct: 683  LNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV 742

Query: 321  NARKFEEMNAELEENKELAQN---RLCELEKLRQDFEEVTTQN----EKLKVELRSAVEQ 373
             A K E+   +L++ ++L  +   R  EL K  +  +E+ +      +K    L S  ++
Sbjct: 743  KASK-EQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK 801

Query: 374  VVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKK 433
            + K+  E + ++  F  L  E+   K   +E    +         Q  + E  +V + K+
Sbjct: 802  LTKQEEEKQILKQDFETLSQET---KIQHEELNNRI---------QTTVTELQKVKMEKE 849

Query: 434  -LRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQA----GPINREMRHLISSLQNHNH 488
             L TE+  ++D L++V    +  + EFE+     + A        +E++H +     +  
Sbjct: 850  ALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTL 909

Query: 489  QLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSS 548
            + + E+ +   K +EA   L          L+Q+Q++ +  + E  +L+ +  +L  QSS
Sbjct: 910  KEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK-QSS 968

Query: 549  ASKASQEDANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAK 608
              K  Q +A + + K    ++  E   K +++  +  +E   E+EK  + ++  E+    
Sbjct: 969  EQKKKQIEALQGELKIAVLQKT-ELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQET 1027

Query: 609  DKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAA-- 666
             K+      GR+ E    +Q   +LK  +E     +  L   R+    Q   +Q +    
Sbjct: 1028 FKQLQSDFYGRESELLATRQ---DLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAK 1084

Query: 667  ---EKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQ 723
               E+ S  + + L++R K L+D +K+++ K  +    +   A  E+I+  Q+K      
Sbjct: 1085 ATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLN 1144

Query: 724  EE---EALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHK-LLKE 779
            EE     L S  ++T    +D ++  I+   +L+ K D+    + +  ++ QI K  +K+
Sbjct: 1145 EELKSHKLESIKEITN--LKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKK 1202

Query: 780  EKEELADQVLTLKTQVDAQLQV----VRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKR 835
            E+EEL  + +  + ++ ++++     ++K EE E  L   I    + LG   +  + ++R
Sbjct: 1203 EEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQR 1262

Query: 836  KAMEAAQLADDLKAQLELAQKKLHDFQDE---IVENSVTKEKDMFNFKRAQEDISRLRRK 892
            +  E  +  DDL+ ++ + +  + + QDE   ++E  +  E ++   ++ Q  +  L+RK
Sbjct: 1263 RVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEI---EKLQTKVLELQRK 1319

Query: 893  LETT---------KKPDNVPKCDEILMEEIKDYKARLTCPCCNMRKKDAV----LTKCFH 939
            L+ T         +      K  + L  +  +      C  C       V      +C +
Sbjct: 1320 LDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRRHHCRQCGN 1379

Query: 940  VFCFECVKTRYDTRQRKCP--KCNAAF 964
            +FC EC      T   K P   C+A F
Sbjct: 1380 IFCAECSAKNALTPSSKKPVRVCDACF 1406



 Score =  111 bits (277), Expect = 4e-24
 Identities = 176/941 (18%), Positives = 405/941 (43%), Gaps = 121/941 (12%)

Query: 45   ELDIRTLQTKN---RKLAEMLDQRQA-IEDELREHIEKLERRQATDDASLLIVNRYWSQF 100
            E  +   QT+N   +++ ++ +Q+ A +  E+ +   K +  ++  +A+   V R   + 
Sbjct: 141  EQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEEL 200

Query: 101  DENIRII--LKRYDLEQ-GLGDLLTERKALVVPEPEPDSDS-NQERKDDRERGEGQEPAF 156
            ++   +I  LK   L++ G+ D+   +K LV  +   D+ +  +ER+ ++ + E ++   
Sbjct: 201  NKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQS 260

Query: 157  SFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNS-GDNLIV- 214
             +      +SSE   SQL+  +    + V+  V    KL+  V  L++K  +  +NL+  
Sbjct: 261  QY------ASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314

Query: 215  ------------EEAVQELN--SFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETA 260
                        EE+V + N  + L Q+++  Q+L   L     ++ +   +L  K E  
Sbjct: 315  EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEAT 374

Query: 261  ES---RVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGT 317
            +     +S +E+    L+ +  +++++ +   +H  ++   +N    K+           
Sbjct: 375  QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLET-------- 426

Query: 318  ITINARKFEEMNAELEENKELAQNRLCELEKLRQDFE-EVTTQNEKLK------VELRSA 370
                 R+  E +  L+E ++L+  +L + E+   D + +++   E+LK       EL+  
Sbjct: 427  ----ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ 482

Query: 371  VEQVVKETPEYRCMQSQFSVLYNES-------LQLKAHLDEARTLLHGTRGTHQHQVELI 423
            +++  ++  E + +Q   +    E+       L+     D+    L       +  + L+
Sbjct: 483  LDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLL 542

Query: 424  ERDEVSLHKKLR-----TEVI-QLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMR 477
            E++   L+ K++     T V+ QL++    ++++   L  + +    +++QA      + 
Sbjct: 543  EKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQA---QENLH 599

Query: 478  HLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELK 537
              +   + H    +  VL  +  + E  S LN+++ +     +Q ++ TE      A   
Sbjct: 600  DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKT 659

Query: 538  PDSEDLSSQ----SSASKASQEDANEIKSKRDE---------------EERERERREK-- 576
                DL +      +A +  Q++ N+I ++ D+               E   +E +EK  
Sbjct: 660  AQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYL 719

Query: 577  --EREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELK 634
              E++ E    + K+ E +  ++K S+++      +++  + D   +  E+ KQL++E +
Sbjct: 720  SLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKE 779

Query: 635  KAQES----QKEMKLLLDMYRSAPKEQRDKVQLM----AAEKKSKAELEDLRQRLKDLED 686
                +    QK+ + L  + +   K++ +K  L        +++K + E+L  R++    
Sbjct: 780  IVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVT 839

Query: 687  KEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQE-----EEALLSEMDVTGQAFED 741
            + +K   KM  E  + ++  V++++  +   L  +K E     ++   + +D+     E 
Sbjct: 840  ELQKV--KMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKEL 897

Query: 742  MQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQV 801
              +  +++   L+E+ +    L  E+  S+Q+   L   +E+L     TLK         
Sbjct: 898  KHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQN------- 950

Query: 802  VRKLEEKEHLLQSNIGTGEKELGLRTQALEMN----KRKAMEAAQLADDLKAQLELAQKK 857
                E++E  LQ NI   ++    + + +E      K   ++  +L + L+ QL  A ++
Sbjct: 951  ----EKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQE 1006

Query: 858  LHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKK 898
            L   +++I       EK    FK+ Q D      +L  T++
Sbjct: 1007 LAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQ 1047



 Score =  109 bits (273), Expect = 1e-23
 Identities = 160/919 (17%), Positives = 394/919 (42%), Gaps = 99/919 (10%)

Query: 47  DIRTLQTKNRKLAEMLDQRQAIEDELREHIEK---LERRQATDDASLLIVNRYWSQFDEN 103
           D+  L+ + + L   L + +   +EL++ +EK   L++++A  D  +   +      ++ 
Sbjct: 84  DVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQ 143

Query: 104 IRII-LKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATL 162
           +     + ++++Q + DL  ++ A +  E         E +  RE  E +    +     
Sbjct: 144 LEEAQTENFNIKQ-MKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNK 202

Query: 163 ASSSSEEMESQLQER-----VESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEA 217
            ++  ++++++L +R     V   ++ + Q+ T+ D +  + E  S KL        ++ 
Sbjct: 203 EATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKL--------KDE 254

Query: 218 VQELNSFLAQENMRLQELTDLLQEKHRTMS---QEFSKLQSKVETAESRVSVLESMIDDL 274
            ++L S  A     + +L   L +  + ++   QE  KL+S V     +   L   +   
Sbjct: 255 CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314

Query: 275 QWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEE 334
           + D  K+ ++    +     +   ++ K        S L     +++      ++ EL E
Sbjct: 315 EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLH-----RIHVELSE 369

Query: 335 NKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNE 394
             E  Q       KL+++  EV T+ + LK E +   +Q  ++      +QS+ + L+++
Sbjct: 370 KGEATQ-------KLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422

Query: 395 SLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEM 454
            L+ +  L EA    HG          L E+ ++S  +KL  +  Q+ D   ++ +  E 
Sbjct: 423 LLETERQLGEA----HG---------RLKEQRQLS-SEKLMDKEQQVADLQLKLSRLEEQ 468

Query: 455 LRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLR 514
           L+ +              + E++H +   +  + + +        KLREAQ+DL +   +
Sbjct: 469 LKEKVTN-----------STELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQ 517

Query: 515 SG---SALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSK----RDEE 567
            G     +   ++  +  K+  + L+ + EDL ++  A +      N+++ K    +++ 
Sbjct: 518 IGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQV 577

Query: 568 ERERERREKEREREREREKEKEREREKQKLK-ESEKERDSAKDKEKGKHDDGRKKEAEII 626
            +  E+ + + E  ++ ++    + ++QK    + ++R  + +    + +    +  E +
Sbjct: 578 TQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKV 637

Query: 627 KQLKIELKKAQE-----------SQKEMKLLLDMYRSAPKEQRDKVQLMAAE-KKSKAEL 674
            QL I++K   E            + +++  LD  ++A ++++ ++  +  +  +  A+L
Sbjct: 638 SQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKL 697

Query: 675 EDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDV 734
           +D ++    LE   K+  +K    +  +K   +E QI+ L+      K  +E  L ++  
Sbjct: 698 QDKQEHCSQLESHLKEYKEKYLSLE--QKTEELEGQIKKLEADSLEVKASKEQALQDLQQ 755

Query: 735 TGQAFEDMQEQNIRLMQQ--------------LREKDDANFKLMSERIKSNQIHKLLKEE 780
             Q   D++ +   L +Q              L++K +A   +  +  K  +  ++LK++
Sbjct: 756 QRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQD 815

Query: 781 KEELADQVLTLKTQVDAQLQV----VRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRK 836
            E L+ +      +++ ++Q     ++K++ ++  L + + T + +L   + +L+ +K +
Sbjct: 816 FETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSE 875

Query: 837 AMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETT 896
             +  Q        LE   K+L       +EN++ ++K++      +++ S  + KLE  
Sbjct: 876 FEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASH-QLKLELN 934

Query: 897 KKPDNVPKCDEILMEEIKD 915
              + + +    L +  K+
Sbjct: 935 SMQEQLIQAQNTLKQNEKE 953



 Score =  105 bits (263), Expect = 2e-22
 Identities = 169/813 (20%), Positives = 341/813 (41%), Gaps = 126/813 (15%)

Query: 206 LNSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVS 265
           L   D  ++ + VQ+L + L +E    +EL   L EK++ + Q+ +K    V  + + + 
Sbjct: 80  LKRDDVTLLRQEVQDLQASLKEEKWYSEELKKEL-EKYQGLQQQEAKPDGLVTDSSAELQ 138

Query: 266 VLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKF 325
            LE  +++ Q +   I++ +    +  A++   +     K Y    SL         R  
Sbjct: 139 SLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSK-YDEERSLREAAEQKVTRLT 197

Query: 326 EEMNAE----------------LEE----NKELAQ----------NRLCELEKLRQDFEE 355
           EE+N E                +E+     KEL Q           R  E EKL+ + ++
Sbjct: 198 EELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKK 257

Query: 356 VTTQN-------EKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQL---------- 398
           + +Q         +L+ EL    ++V     E + ++S  + L  ++  L          
Sbjct: 258 LQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQD 317

Query: 399 -----KAHLDEARTLLHGTRGTHQHQVEL------IERDEVSLHKKLRTEVIQ------- 440
                + H +E+ +  +     HQ  ++       +   E SLH ++  E+ +       
Sbjct: 318 YTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLH-RIHVELSEKGEATQK 376

Query: 441 LEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRK 500
           L++ L++V  +Y+ L+ EF+Q     E+     +E   L   LQ+  +QL  ++L  +R+
Sbjct: 377 LKEELSEVETKYQHLKAEFKQLQQQREE-----KEQHGL--QLQSEINQLHSKLLETERQ 429

Query: 501 LREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEI 560
           L EA   L + R  S   L+  +    D + + + L+   E L  + + S   Q   ++ 
Sbjct: 430 LGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLE---EQLKEKVTNSTELQHQLDKT 486

Query: 561 KSKRDEEER-ERERREKEREREREREKEKEREREK-QKLKESE----KERDSAKDKEKGK 614
           K +  E++  ++    K RE + + E+   +  +K QK++  E    K +++    EK +
Sbjct: 487 KQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKER 546

Query: 615 HD-----DGRKKEAEIIKQLKIELKKAQES----QKEMKLLLDMYRSAPKEQRDKVQLMA 665
            D        + E  ++ QL+ +    QE      +++K   + ++ A +   D+VQ   
Sbjct: 547 EDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQ--- 603

Query: 666 AEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEE 725
              + KA L   + R+  LE    + N ++   ++  K+  ++ QI+   + L  A+  +
Sbjct: 604 ---EQKAHLRAAQDRVLSLETSVNELNSQL--NESKEKVSQLDIQIKAKTELLLSAEAAK 658

Query: 726 EA----LLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEK 781
            A    L + +D    A +D Q++  ++  QL   D    KL  ++   +Q+   LKE K
Sbjct: 659 TAQRADLQNHLDTAQNALQDKQQELNKITTQL---DQVTAKLQDKQEHCSQLESHLKEYK 715

Query: 782 EELADQVLTLKTQVDAQLQVVRKLE--------EKEHLLQSNIGTGEKELGLRTQALEMN 833
           E    + L+L+ + +     ++KLE         KE  LQ      +    L  +A E++
Sbjct: 716 E----KYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELS 771

Query: 834 KRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDI----SRL 889
           K+  ME  ++    +  L+   + L   + ++ +    K+    +F+   ++       L
Sbjct: 772 KQLEME-KEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEEL 830

Query: 890 RRKLETT-KKPDNVPKCDEILMEEIKDYKARLT 921
             +++TT  +   V    E LM E+   K +L+
Sbjct: 831 NNRIQTTVTELQKVKMEKEALMTELSTVKDKLS 863



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 167/836 (19%), Positives = 338/836 (40%), Gaps = 153/836 (18%)

Query: 27   DSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATD 86
            ++  T +   L     T +  ++  Q +  K+   LDQ  A   + +EH  +LE      
Sbjct: 655  EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLE------ 708

Query: 87   DASLLIVNRYWSQFDENIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDR 146
                     +  ++ E      K   LEQ   +L  + K L     E  +   Q  +D +
Sbjct: 709  --------SHLKEYKE------KYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQ 754

Query: 147  ERGEGQEPAFSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKL 206
            ++ +             ++  E   ++L +++E  +  VS       K  E +E + +KL
Sbjct: 755  QQRQ------------LNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802

Query: 207  NSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQEKHRTMSQE----FSKLQSKVETAES 262
                                    + +E   +L++   T+SQE      +L ++++T  +
Sbjct: 803  T-----------------------KQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVT 839

Query: 263  RVSVL----ESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTI 318
             +  +    E+++ +L    DK+ K    L    +E  E+ N KG              I
Sbjct: 840  ELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSE-FEKENQKG-----------KAAI 887

Query: 319  TINARKFEEMNAELEENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKET 378
                +  +E+  +L+   E   N L E ++L++  E+    + +LK+EL S  EQ+++  
Sbjct: 888  LDLEKTCKELKHQLQVQME---NTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQ 944

Query: 379  PEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEV 438
               +  + +   L     +LK   ++ +  +   +G    ++++    +  L  KL+ ++
Sbjct: 945  NTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQG----ELKIAVLQKTELENKLQQQL 1000

Query: 439  IQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYK 498
             Q    LA  +++  +L+  +E++    +Q   +  +     S L      LK      +
Sbjct: 1001 TQAAQELAAEKEKISVLQNNYEKSQETFKQ---LQSDFYGRESELLATRQDLKS----VE 1053

Query: 499  RKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDAN 558
             KL  AQ DL   R + G+         ++ K   A L+ DS                  
Sbjct: 1054 EKLSLAQEDLISNRNQIGN----QNKLIQELKTAKATLEQDS------------------ 1091

Query: 559  EIKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDG 618
               +K++++ +ER +  ++ ++E+   KEKE   EK KL E E E    ++KE  K +  
Sbjct: 1092 ---AKKEQQLQERCKALQDIQKEKSL-KEKELVNEKSKLAEIE-EIKCRQEKEITKLN-- 1144

Query: 619  RKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLR 678
                 E +K  K+E  K   + K+ K LL          + K++L       KA +E  +
Sbjct: 1145 -----EELKSHKLESIKEITNLKDAKQLL---------IQQKLELQGKADSLKAAVEQEK 1190

Query: 679  QRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVT--- 735
            +  + L+D+ KKE +++  E  + K   +  +I+  +K++ M K EE      M +T   
Sbjct: 1191 RNQQILKDQVKKEEEELKKE-FIEKEAKLHSEIK--EKEVGMKKHEENEAKLTMQITALN 1247

Query: 736  ---GQAFEDMQEQNIRLMQQLREKDD--ANFKLMSERIKSNQIHKLLKEEKEELADQVLT 790
               G   ++ Q    R+ +  ++ DD      ++   +++NQ      +E+  L ++ L 
Sbjct: 1248 ENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQ------DERRALLERCLK 1301

Query: 791  LKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADD 846
             + +++     V +L+ K      N     +ELG   Q+L++   +A+      D+
Sbjct: 1302 GEGEIEKLQTKVLELQRK----LDNTTAAVQELGRENQSLQIKHTQALNRKWAEDN 1353


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  132 bits (331), Expect = 2e-30
 Identities = 195/888 (21%), Positives = 378/888 (42%), Gaps = 105/888 (11%)

Query: 51   LQTKNRKLAEMLDQRQAIEDELRE----HIEKLERRQATDDASLLIVNRYWSQFDENIRI 106
            +Q K  +L +  +++Q  E+EL+E    H +  E +    +        Y    +  +R+
Sbjct: 854  MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL 913

Query: 107  ILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSS 166
              K+ +LE    ++L E +A +    E + D  Q+ + +R++               +  
Sbjct: 914  AAKKQELE----EILHEMEARL----EEEEDRGQQLQAERKK--------------MAQQ 951

Query: 167  SEEMESQLQERVESSRRAVSQIVTV---YDKLQEKVELLSRKLN--SGDNLIVEEAVQEL 221
              ++E QL+E   + ++   + VT      KL++++ ++  + N  S +  ++EE + +L
Sbjct: 952  MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1011

Query: 222  NSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKI 281
             + LA+E  + + LT  L+ KH +M    S+L+ +++  E     LE +   L+ D    
Sbjct: 1012 TTNLAEEEEKAKNLTK-LKNKHESM---ISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067

Query: 282  RKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITIN--ARKFEEMNAELEENKELA 339
             ++   L   +AE+  ++  K  ++  A + L       N   +K  E+   + + +E  
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127

Query: 340  QNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLK 399
             +      K  +   ++  + E LK EL   ++    +  E R  + Q      E   LK
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ-QELRAKREQ------EVTVLK 1180

Query: 400  AHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEF 459
              LDE       TR +H+ QV+ + +      ++L  ++ Q +   A + K  + L  E 
Sbjct: 1181 KALDEE------TR-SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233

Query: 460  EQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSAL 519
                      G   +E+ H    L+    +L+ +    +R    A+++LN    +  + +
Sbjct: 1234 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER----ARAELNDKVHKLQNEV 1289

Query: 520  LQSQSSTEDPKDEPAELKPDSEDLSSQ-SSASKASQEDANE-----IKSKRDEEERERER 573
                    + + +  +L  D   LSSQ     +  QE+  +      K ++ EEER   +
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349

Query: 574  REKEREREREREKEKEREREKQKLKESEKE-RDSAKDKEKGKHDDGRKKEAEIIKQL--- 629
             + + E E ++  E+       +L +S+K+ +D A   E    ++G+K+  + I+ L   
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE--ALEEGKKRFQKEIENLTQQ 1407

Query: 630  ---------KIELKKAQESQKEMKLLLD------MYRSAPKEQRDKVQLMAAEKKSKAEL 674
                     K+E  K +  Q+   L++D      +  +  K+QR   QL+A EK   ++ 
Sbjct: 1408 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1467

Query: 675  EDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDV 734
             D R R +   +  +KE K ++   AL +    +E++E   K   M K E E L+S  D 
Sbjct: 1468 ADERDRAE--AEAREKETKALSLARALEEALEAKEELERTNK---MLKAEMEDLVSSKDD 1522

Query: 735  TGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQ 794
             G+   ++++    L  Q+ E      K   E ++     +  ++ K  L   +  LK Q
Sbjct: 1523 VGKNVHELEKSKRALETQMEE-----MKTQLEELEDEL--QATEDAKLRLEVNMQALKGQ 1575

Query: 795  VDAQLQV-VRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAA---QLADDLKAQ 850
             +  LQ    + EEK   LQ  +   E EL       +  K++A+ AA   +L  DLK  
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELE------DERKQRALAAAAKKKLEGDLK-D 1628

Query: 851  LELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKK 898
            LEL        ++E ++     +  M +F+R  ED    R ++  T K
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1676



 Score =  109 bits (273), Expect = 1e-23
 Identities = 157/818 (19%), Positives = 338/818 (41%), Gaps = 107/818 (13%)

Query: 27   DSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATD 86
            D G  +E +K   +  T +      + + ++  E+   ++A+++E R H  +++  +   
Sbjct: 1143 DLGEELEALKTE-LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201

Query: 87   DASLLIVNRYWSQFDE-NIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDD 145
              ++  +     QF      +   +  LE+   DL  E + L          + QE +  
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL--------GQAKQEVEHK 1253

Query: 146  RERGEGQEPAFSFLATLASSSSEEMESQ---LQERVESSRRAVSQIVTVYDKLQEKVELL 202
            +++ E Q        +    +  E+  +   LQ  VES    +++      KL + V  L
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313

Query: 203  SRKLNSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAES 262
            S +L     L+ EE  Q+LN  ++ +  +L+E  + LQ++     +    L+  + T   
Sbjct: 1314 SSQLQDTQELLQEETRQKLN--VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNI 1371

Query: 263  RVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINA 322
            ++S  +  + D    ++ + + ++R  + +  + ++   K      A       T     
Sbjct: 1372 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA-----AAYDKLEKTKNRLQ 1426

Query: 323  RKFEEMNAELEENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYR 382
            ++ +++  +L+  ++L  N    LEK ++ F+++  + + +  +     ++   E  E  
Sbjct: 1427 QELDDLVVDLDNQRQLVSN----LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482

Query: 383  CMQSQFSVLYNESLQLKAHLDEARTLLHGTR----------GTHQHQVELIERDEVSLHK 432
                  +    E+L+ K  L+    +L              G + H++E  +R   +  +
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542

Query: 433  KLRTEVIQLEDTL-----AQVRKEYEM--LRIEFEQTLAANEQAGPINREMRHLISSLQN 485
            +++T++ +LED L     A++R E  M  L+ +FE+ L A ++    N E R  +   Q 
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ---NEEKRRQLQR-QL 1598

Query: 486  HNHQLKGEVLRYKRKLREA-----QSDLNKTRLRSGSAL------------LQSQSSTED 528
            H ++ + E  R +R L  A     + DL    L++ SA+            LQ+Q     
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658

Query: 529  PKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREK-- 586
             + E A    D    +++ +  KA   +A+ ++ + D    ER R++ + E+E   E+  
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718

Query: 587  -----EKEREREKQKLKESEKERDSAKDKEKGKHD---DGRKKEAEIIKQLKIELKKAQE 638
                     + EK++L+    + +   ++E+G  +   D  +K  +  +QL  EL   + 
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778

Query: 639  SQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSK------------AELEDLRQR------ 680
            + ++ +          KE R K+  M    KSK            A+LE+  ++      
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838

Query: 681  --LKDLEDKEKK---------ENKKMAD------EDALRKIRAVEEQIEYLQKKLAMAKQ 723
               K L+ K+KK         + +KMA+      E    +++ ++ Q+E  +++      
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898

Query: 724  EEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANF 761
                L  E+D   ++ E M  +   L  +LR  ++ +F
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSF 1936



 Score =  108 bits (270), Expect = 2e-23
 Identities = 166/830 (20%), Positives = 353/830 (42%), Gaps = 91/830 (10%)

Query: 47   DIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATD-----------DASLLIVNR 95
            ++  L+ K+  +   L+ R   E++ R+ +EKL+R+   D            A +  +  
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083

Query: 96   YWSQFDENIRIILKRYDLEQGL-GDLLTERKALV--VPEPEPDSDS-----NQERKDDRE 147
              ++ +E ++  L R D E     + L + + L   + + + D DS     N+  K  R+
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143

Query: 148  RGEGQEPAFSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLN 207
             GE  E   + L     S++ + E + +   E     V+ +    D+     E   +++ 
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQE-----VTVLKKALDEETRSHEAQVQEMR 1198

Query: 208  SGDNLIVEEAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVL 267
                  VEE  ++L  F  +    L +    L++++  ++ E   L    +  E +   L
Sbjct: 1199 QKHAQAVEELTEQLEQF-KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257

Query: 268  ESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEE 327
            E+ + +LQ       +    LN  + ++   V S    V G  +   G  I + A+    
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVES----VTGMLNEAEGKAIKL-AKDVAS 1312

Query: 328  MNAELEENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQ 387
            ++++L++ +EL Q      E+ RQ    V+T+  +L+ E  S  +Q+ +E    + ++  
Sbjct: 1313 LSSQLQDTQELLQ------EETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365

Query: 388  FSVLYNESLQLKAHL-DEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLA 446
             S L  +    K  L D A T+     G  + Q E+   +    +++      +LE T  
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI--ENLTQQYEEKAAAYDKLEKTKN 1423

Query: 447  QVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQS 506
            ++++E + L ++ +             R+   L++  +N + +   E  R + + RE ++
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483

Query: 507  DLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDE 566
                  L    AL ++  + E+ +     LK + EDL S       S++D       ++ 
Sbjct: 1484 KA----LSLARALEEALEAKEELERTNKMLKAEMEDLVS-------SKDDVG-----KNV 1527

Query: 567  EERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEII 626
             E E+ +R  E + E  + + +E E E Q  ++++   +      KG+ +          
Sbjct: 1528 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE---------- 1577

Query: 627  KQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLED 686
            + L+   ++ +E +++++  L  Y +  +++R +  L AA KK       L   LKDLE 
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK------LEGDLKDLEL 1631

Query: 687  KEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQN 746
            +     K    E+A++++R ++ Q++  Q++L  A+   + + +      +  + ++   
Sbjct: 1632 QADSAIK--GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1689

Query: 747  IRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLE 806
            ++L + L   + A               K    EKEELA+++ +  +  +A     R+LE
Sbjct: 1690 MQLQEDLAAAERAR--------------KQADLEKEELAEELASSLSGRNALQDEKRRLE 1735

Query: 807  EKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQK 856
             +   L+  +   E+E G      +  ++   +A QL+++L  +   AQK
Sbjct: 1736 ARIAQLEEEL---EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 159/717 (22%), Positives = 296/717 (41%), Gaps = 118/717 (16%)

Query: 283  KREQRLN------RHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNA---ELE 333
            KR+Q+L       R+ A  L+  N + ++++     L   T     R+ EEM A   EL+
Sbjct: 808  KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVT-----RQEEEMQAKEDELQ 862

Query: 334  ENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCM-----QSQF 388
            + KE  Q    EL++L Q   ++T +   L+ +L++  E +  E  E R       Q   
Sbjct: 863  KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE-LYAEAEEMRVRLAAKKQELE 921

Query: 389  SVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIE--------RDEVSLHK-------- 432
             +L+    +L+   D  + L    +   Q  ++L E        R ++ L K        
Sbjct: 922  EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 981

Query: 433  KLRTEVIQLEDTLAQVRKEYEML--RIEFEQTLAANEQAGPIN-----REMRHLISSLQ- 484
            KL  E++ ++D   ++ KE ++L  RI    T  A E+    N      +   +IS L+ 
Sbjct: 982  KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1041

Query: 485  --NHNHQLKGEVLRYKRKLREAQSDLNK--TRLRSGSALLQSQSSTEDPKDEPAELKPDS 540
                  + + E+ + KRKL    SD ++    L++  A L+ Q + ++ + + A  + D 
Sbjct: 1042 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD 1101

Query: 541  EDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREKEKE----------- 589
            E ++ +++A K  +E    I   +++ + ER  R K  +++R+  +E E           
Sbjct: 1102 E-IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1160

Query: 590  --------REREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQK 641
                    R + +Q++   +K  D      + +  + R+K A+ +++L  +L    E  K
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL----EQFK 1216

Query: 642  EMKLLLDMYRSA-PKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDA 700
              K  LD  +    KE  D    +    ++K E+E    + K LE + ++   K +D + 
Sbjct: 1217 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE---HKKKKLEAQVQELQSKCSDGER 1273

Query: 701  LR-----KIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLRE 755
             R     K+  ++ ++E +   L  A+ +   L  ++       +D QE    L ++ R+
Sbjct: 1274 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL---LQEETRQ 1330

Query: 756  KDDANFKLMSERIKSNQIHKLLKEE---KEELADQVLTLKTQVD---AQLQ----VVRKL 805
            K + + KL     + N +   L EE   K+ L   + TL  Q+     +LQ     V  L
Sbjct: 1331 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1390

Query: 806  EEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLE------------- 852
            EE +   Q  I    ++   +  A +  ++      Q  DDL   L+             
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1450

Query: 853  ------LAQK-----KLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKK 898
                  LA++     K  D +D     +  KE    +  RA E+    + +LE T K
Sbjct: 1451 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1507



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 80/363 (22%), Positives = 183/363 (50%), Gaps = 24/363 (6%)

Query: 573  RREKERE-REREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKI 631
            R+E+E + +E E +K KER+++ +   +  +++ S   +EK    +  + E E+  + + 
Sbjct: 849  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908

Query: 632  ELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKA-ELEDLRQRLKDLEDKEKK 690
               +    ++E++ +L    +  +E+ D+ Q + AE+K  A ++ DL ++L+  E++  +
Sbjct: 909  MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE--EEEAAR 966

Query: 691  ENKKMADEDALRKIRAVEEQIEYL---QKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNI 747
            +  ++    A  KI+ +E++I  +     KL+  ++  E  +S++  T  A E+ + +N+
Sbjct: 967  QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL-TTNLAEEEEKAKNL 1025

Query: 748  RLMQQLREK--DDANFKLMSERIKSNQIHKL---LKEEKEELADQVLTLKTQVDAQLQVV 802
              ++   E    +   +L  E     ++ KL   L+ +  +  +Q+  L+ Q+ A+L++ 
Sbjct: 1026 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI-AELKM- 1083

Query: 803  RKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDL---KAQLELAQKKLH 859
             +L +KE  LQ+ +   + E+  +  AL+  +      + L +DL   +A    A+K+  
Sbjct: 1084 -QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142

Query: 860  DFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETT---KKPDNVPKCDEILMEEIKDY 916
            D  +E+ E   T+ +D  +    Q+++ R +R+ E T   K  D   +  E  ++E++  
Sbjct: 1143 DLGEEL-EALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1200

Query: 917  KAR 919
             A+
Sbjct: 1201 HAQ 1203


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  132 bits (331), Expect = 2e-30
 Identities = 195/888 (21%), Positives = 378/888 (42%), Gaps = 105/888 (11%)

Query: 51   LQTKNRKLAEMLDQRQAIEDELRE----HIEKLERRQATDDASLLIVNRYWSQFDENIRI 106
            +Q K  +L +  +++Q  E+EL+E    H +  E +    +        Y    +  +R+
Sbjct: 861  MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL 920

Query: 107  ILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSS 166
              K+ +LE    ++L E +A +    E + D  Q+ + +R++               +  
Sbjct: 921  AAKKQELE----EILHEMEARL----EEEEDRGQQLQAERKK--------------MAQQ 958

Query: 167  SEEMESQLQERVESSRRAVSQIVTV---YDKLQEKVELLSRKLN--SGDNLIVEEAVQEL 221
              ++E QL+E   + ++   + VT      KL++++ ++  + N  S +  ++EE + +L
Sbjct: 959  MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018

Query: 222  NSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKI 281
             + LA+E  + + LT  L+ KH +M    S+L+ +++  E     LE +   L+ D    
Sbjct: 1019 TTNLAEEEEKAKNLTK-LKNKHESM---ISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074

Query: 282  RKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITIN--ARKFEEMNAELEENKELA 339
             ++   L   +AE+  ++  K  ++  A + L       N   +K  E+   + + +E  
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134

Query: 340  QNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLK 399
             +      K  +   ++  + E LK EL   ++    +  E R  + Q      E   LK
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ-QELRAKREQ------EVTVLK 1187

Query: 400  AHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEF 459
              LDE       TR +H+ QV+ + +      ++L  ++ Q +   A + K  + L  E 
Sbjct: 1188 KALDEE------TR-SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240

Query: 460  EQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSAL 519
                      G   +E+ H    L+    +L+ +    +R    A+++LN    +  + +
Sbjct: 1241 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER----ARAELNDKVHKLQNEV 1296

Query: 520  LQSQSSTEDPKDEPAELKPDSEDLSSQ-SSASKASQEDANE-----IKSKRDEEERERER 573
                    + + +  +L  D   LSSQ     +  QE+  +      K ++ EEER   +
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356

Query: 574  REKEREREREREKEKEREREKQKLKESEKE-RDSAKDKEKGKHDDGRKKEAEIIKQL--- 629
             + + E E ++  E+       +L +S+K+ +D A   E    ++G+K+  + I+ L   
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE--ALEEGKKRFQKEIENLTQQ 1414

Query: 630  ---------KIELKKAQESQKEMKLLLD------MYRSAPKEQRDKVQLMAAEKKSKAEL 674
                     K+E  K +  Q+   L++D      +  +  K+QR   QL+A EK   ++ 
Sbjct: 1415 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1474

Query: 675  EDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDV 734
             D R R +   +  +KE K ++   AL +    +E++E   K   M K E E L+S  D 
Sbjct: 1475 ADERDRAE--AEAREKETKALSLARALEEALEAKEELERTNK---MLKAEMEDLVSSKDD 1529

Query: 735  TGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQ 794
             G+   ++++    L  Q+ E      K   E ++     +  ++ K  L   +  LK Q
Sbjct: 1530 VGKNVHELEKSKRALETQMEE-----MKTQLEELEDEL--QATEDAKLRLEVNMQALKGQ 1582

Query: 795  VDAQLQV-VRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAA---QLADDLKAQ 850
             +  LQ    + EEK   LQ  +   E EL       +  K++A+ AA   +L  DLK  
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELE------DERKQRALAAAAKKKLEGDLK-D 1635

Query: 851  LELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKK 898
            LEL        ++E ++     +  M +F+R  ED    R ++  T K
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1683



 Score =  109 bits (273), Expect = 1e-23
 Identities = 157/818 (19%), Positives = 338/818 (41%), Gaps = 107/818 (13%)

Query: 27   DSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATD 86
            D G  +E +K   +  T +      + + ++  E+   ++A+++E R H  +++  +   
Sbjct: 1150 DLGEELEALKTE-LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208

Query: 87   DASLLIVNRYWSQFDE-NIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDD 145
              ++  +     QF      +   +  LE+   DL  E + L          + QE +  
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL--------GQAKQEVEHK 1260

Query: 146  RERGEGQEPAFSFLATLASSSSEEMESQ---LQERVESSRRAVSQIVTVYDKLQEKVELL 202
            +++ E Q        +    +  E+  +   LQ  VES    +++      KL + V  L
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320

Query: 203  SRKLNSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAES 262
            S +L     L+ EE  Q+LN  ++ +  +L+E  + LQ++     +    L+  + T   
Sbjct: 1321 SSQLQDTQELLQEETRQKLN--VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNI 1378

Query: 263  RVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINA 322
            ++S  +  + D    ++ + + ++R  + +  + ++   K      A       T     
Sbjct: 1379 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA-----AAYDKLEKTKNRLQ 1433

Query: 323  RKFEEMNAELEENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYR 382
            ++ +++  +L+  ++L  N    LEK ++ F+++  + + +  +     ++   E  E  
Sbjct: 1434 QELDDLVVDLDNQRQLVSN----LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489

Query: 383  CMQSQFSVLYNESLQLKAHLDEARTLLHGTR----------GTHQHQVELIERDEVSLHK 432
                  +    E+L+ K  L+    +L              G + H++E  +R   +  +
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549

Query: 433  KLRTEVIQLEDTL-----AQVRKEYEM--LRIEFEQTLAANEQAGPINREMRHLISSLQN 485
            +++T++ +LED L     A++R E  M  L+ +FE+ L A ++    N E R  +   Q 
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ---NEEKRRQLQR-QL 1605

Query: 486  HNHQLKGEVLRYKRKLREA-----QSDLNKTRLRSGSAL------------LQSQSSTED 528
            H ++ + E  R +R L  A     + DL    L++ SA+            LQ+Q     
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665

Query: 529  PKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREK-- 586
             + E A    D    +++ +  KA   +A+ ++ + D    ER R++ + E+E   E+  
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725

Query: 587  -----EKEREREKQKLKESEKERDSAKDKEKGKHD---DGRKKEAEIIKQLKIELKKAQE 638
                     + EK++L+    + +   ++E+G  +   D  +K  +  +QL  EL   + 
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785

Query: 639  SQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSK------------AELEDLRQR------ 680
            + ++ +          KE R K+  M    KSK            A+LE+  ++      
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845

Query: 681  --LKDLEDKEKK---------ENKKMAD------EDALRKIRAVEEQIEYLQKKLAMAKQ 723
               K L+ K+KK         + +KMA+      E    +++ ++ Q+E  +++      
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905

Query: 724  EEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANF 761
                L  E+D   ++ E M  +   L  +LR  ++ +F
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSF 1943



 Score =  108 bits (270), Expect = 2e-23
 Identities = 166/830 (20%), Positives = 353/830 (42%), Gaps = 91/830 (10%)

Query: 47   DIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATD-----------DASLLIVNR 95
            ++  L+ K+  +   L+ R   E++ R+ +EKL+R+   D            A +  +  
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090

Query: 96   YWSQFDENIRIILKRYDLEQGL-GDLLTERKALV--VPEPEPDSDS-----NQERKDDRE 147
              ++ +E ++  L R D E     + L + + L   + + + D DS     N+  K  R+
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150

Query: 148  RGEGQEPAFSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLN 207
             GE  E   + L     S++ + E + +   E     V+ +    D+     E   +++ 
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQE-----VTVLKKALDEETRSHEAQVQEMR 1205

Query: 208  SGDNLIVEEAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVL 267
                  VEE  ++L  F  +    L +    L++++  ++ E   L    +  E +   L
Sbjct: 1206 QKHAQAVEELTEQLEQF-KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264

Query: 268  ESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEE 327
            E+ + +LQ       +    LN  + ++   V S    V G  +   G  I + A+    
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVES----VTGMLNEAEGKAIKL-AKDVAS 1319

Query: 328  MNAELEENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQ 387
            ++++L++ +EL Q      E+ RQ    V+T+  +L+ E  S  +Q+ +E    + ++  
Sbjct: 1320 LSSQLQDTQELLQ------EETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372

Query: 388  FSVLYNESLQLKAHL-DEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLA 446
             S L  +    K  L D A T+     G  + Q E+   +    +++      +LE T  
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI--ENLTQQYEEKAAAYDKLEKTKN 1430

Query: 447  QVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQS 506
            ++++E + L ++ +             R+   L++  +N + +   E  R + + RE ++
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490

Query: 507  DLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDE 566
                  L    AL ++  + E+ +     LK + EDL S       S++D       ++ 
Sbjct: 1491 KA----LSLARALEEALEAKEELERTNKMLKAEMEDLVS-------SKDDVG-----KNV 1534

Query: 567  EERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEII 626
             E E+ +R  E + E  + + +E E E Q  ++++   +      KG+ +          
Sbjct: 1535 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE---------- 1584

Query: 627  KQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLED 686
            + L+   ++ +E +++++  L  Y +  +++R +  L AA KK       L   LKDLE 
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK------LEGDLKDLEL 1638

Query: 687  KEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQN 746
            +     K    E+A++++R ++ Q++  Q++L  A+   + + +      +  + ++   
Sbjct: 1639 QADSAIK--GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1696

Query: 747  IRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLE 806
            ++L + L   + A               K    EKEELA+++ +  +  +A     R+LE
Sbjct: 1697 MQLQEDLAAAERAR--------------KQADLEKEELAEELASSLSGRNALQDEKRRLE 1742

Query: 807  EKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQK 856
             +   L+  +   E+E G      +  ++   +A QL+++L  +   AQK
Sbjct: 1743 ARIAQLEEEL---EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 159/717 (22%), Positives = 296/717 (41%), Gaps = 118/717 (16%)

Query: 283  KREQRLN------RHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNA---ELE 333
            KR+Q+L       R+ A  L+  N + ++++     L   T     R+ EEM A   EL+
Sbjct: 815  KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVT-----RQEEEMQAKEDELQ 869

Query: 334  ENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCM-----QSQF 388
            + KE  Q    EL++L Q   ++T +   L+ +L++  E +  E  E R       Q   
Sbjct: 870  KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE-LYAEAEEMRVRLAAKKQELE 928

Query: 389  SVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIE--------RDEVSLHK-------- 432
             +L+    +L+   D  + L    +   Q  ++L E        R ++ L K        
Sbjct: 929  EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 988

Query: 433  KLRTEVIQLEDTLAQVRKEYEML--RIEFEQTLAANEQAGPIN-----REMRHLISSLQ- 484
            KL  E++ ++D   ++ KE ++L  RI    T  A E+    N      +   +IS L+ 
Sbjct: 989  KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1048

Query: 485  --NHNHQLKGEVLRYKRKLREAQSDLNK--TRLRSGSALLQSQSSTEDPKDEPAELKPDS 540
                  + + E+ + KRKL    SD ++    L++  A L+ Q + ++ + + A  + D 
Sbjct: 1049 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD 1108

Query: 541  EDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREKEKE----------- 589
            E ++ +++A K  +E    I   +++ + ER  R K  +++R+  +E E           
Sbjct: 1109 E-IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1167

Query: 590  --------REREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQK 641
                    R + +Q++   +K  D      + +  + R+K A+ +++L  +L    E  K
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL----EQFK 1223

Query: 642  EMKLLLDMYRSA-PKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDA 700
              K  LD  +    KE  D    +    ++K E+E    + K LE + ++   K +D + 
Sbjct: 1224 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE---HKKKKLEAQVQELQSKCSDGER 1280

Query: 701  LR-----KIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLRE 755
             R     K+  ++ ++E +   L  A+ +   L  ++       +D QE    L ++ R+
Sbjct: 1281 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL---LQEETRQ 1337

Query: 756  KDDANFKLMSERIKSNQIHKLLKEE---KEELADQVLTLKTQVD---AQLQ----VVRKL 805
            K + + KL     + N +   L EE   K+ L   + TL  Q+     +LQ     V  L
Sbjct: 1338 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1397

Query: 806  EEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLE------------- 852
            EE +   Q  I    ++   +  A +  ++      Q  DDL   L+             
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1457

Query: 853  ------LAQK-----KLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKK 898
                  LA++     K  D +D     +  KE    +  RA E+    + +LE T K
Sbjct: 1458 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1514



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 80/363 (22%), Positives = 183/363 (50%), Gaps = 24/363 (6%)

Query: 573  RREKERE-REREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKI 631
            R+E+E + +E E +K KER+++ +   +  +++ S   +EK    +  + E E+  + + 
Sbjct: 856  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915

Query: 632  ELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKA-ELEDLRQRLKDLEDKEKK 690
               +    ++E++ +L    +  +E+ D+ Q + AE+K  A ++ DL ++L+  E++  +
Sbjct: 916  MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE--EEEAAR 973

Query: 691  ENKKMADEDALRKIRAVEEQIEYL---QKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNI 747
            +  ++    A  KI+ +E++I  +     KL+  ++  E  +S++  T  A E+ + +N+
Sbjct: 974  QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL-TTNLAEEEEKAKNL 1032

Query: 748  RLMQQLREK--DDANFKLMSERIKSNQIHKL---LKEEKEELADQVLTLKTQVDAQLQVV 802
              ++   E    +   +L  E     ++ KL   L+ +  +  +Q+  L+ Q+ A+L++ 
Sbjct: 1033 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI-AELKM- 1090

Query: 803  RKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDL---KAQLELAQKKLH 859
             +L +KE  LQ+ +   + E+  +  AL+  +      + L +DL   +A    A+K+  
Sbjct: 1091 -QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149

Query: 860  DFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETT---KKPDNVPKCDEILMEEIKDY 916
            D  +E+ E   T+ +D  +    Q+++ R +R+ E T   K  D   +  E  ++E++  
Sbjct: 1150 DLGEEL-EALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1207

Query: 917  KAR 919
             A+
Sbjct: 1208 HAQ 1210


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  132 bits (331), Expect = 2e-30
 Identities = 195/888 (21%), Positives = 378/888 (42%), Gaps = 105/888 (11%)

Query: 51   LQTKNRKLAEMLDQRQAIEDELRE----HIEKLERRQATDDASLLIVNRYWSQFDENIRI 106
            +Q K  +L +  +++Q  E+EL+E    H +  E +    +        Y    +  +R+
Sbjct: 861  MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL 920

Query: 107  ILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSS 166
              K+ +LE    ++L E +A +    E + D  Q+ + +R++               +  
Sbjct: 921  AAKKQELE----EILHEMEARL----EEEEDRGQQLQAERKK--------------MAQQ 958

Query: 167  SEEMESQLQERVESSRRAVSQIVTV---YDKLQEKVELLSRKLN--SGDNLIVEEAVQEL 221
              ++E QL+E   + ++   + VT      KL++++ ++  + N  S +  ++EE + +L
Sbjct: 959  MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018

Query: 222  NSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKI 281
             + LA+E  + + LT  L+ KH +M    S+L+ +++  E     LE +   L+ D    
Sbjct: 1019 TTNLAEEEEKAKNLTK-LKNKHESM---ISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074

Query: 282  RKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITIN--ARKFEEMNAELEENKELA 339
             ++   L   +AE+  ++  K  ++  A + L       N   +K  E+   + + +E  
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134

Query: 340  QNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLK 399
             +      K  +   ++  + E LK EL   ++    +  E R  + Q      E   LK
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ-QELRAKREQ------EVTVLK 1187

Query: 400  AHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEF 459
              LDE       TR +H+ QV+ + +      ++L  ++ Q +   A + K  + L  E 
Sbjct: 1188 KALDEE------TR-SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1240

Query: 460  EQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSAL 519
                      G   +E+ H    L+    +L+ +    +R    A+++LN    +  + +
Sbjct: 1241 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER----ARAELNDKVHKLQNEV 1296

Query: 520  LQSQSSTEDPKDEPAELKPDSEDLSSQ-SSASKASQEDANE-----IKSKRDEEERERER 573
                    + + +  +L  D   LSSQ     +  QE+  +      K ++ EEER   +
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356

Query: 574  REKEREREREREKEKEREREKQKLKESEKE-RDSAKDKEKGKHDDGRKKEAEIIKQL--- 629
             + + E E ++  E+       +L +S+K+ +D A   E    ++G+K+  + I+ L   
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE--ALEEGKKRFQKEIENLTQQ 1414

Query: 630  ---------KIELKKAQESQKEMKLLLD------MYRSAPKEQRDKVQLMAAEKKSKAEL 674
                     K+E  K +  Q+   L++D      +  +  K+QR   QL+A EK   ++ 
Sbjct: 1415 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1474

Query: 675  EDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDV 734
             D R R +   +  +KE K ++   AL +    +E++E   K   M K E E L+S  D 
Sbjct: 1475 ADERDRAE--AEAREKETKALSLARALEEALEAKEELERTNK---MLKAEMEDLVSSKDD 1529

Query: 735  TGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQ 794
             G+   ++++    L  Q+ E      K   E ++     +  ++ K  L   +  LK Q
Sbjct: 1530 VGKNVHELEKSKRALETQMEE-----MKTQLEELEDEL--QATEDAKLRLEVNMQALKGQ 1582

Query: 795  VDAQLQV-VRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAA---QLADDLKAQ 850
             +  LQ    + EEK   LQ  +   E EL       +  K++A+ AA   +L  DLK  
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELE------DERKQRALAAAAKKKLEGDLK-D 1635

Query: 851  LELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKK 898
            LEL        ++E ++     +  M +F+R  ED    R ++  T K
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1683



 Score =  108 bits (270), Expect = 2e-23
 Identities = 166/830 (20%), Positives = 353/830 (42%), Gaps = 91/830 (10%)

Query: 47   DIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATD-----------DASLLIVNR 95
            ++  L+ K+  +   L+ R   E++ R+ +EKL+R+   D            A +  +  
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090

Query: 96   YWSQFDENIRIILKRYDLEQGL-GDLLTERKALV--VPEPEPDSDS-----NQERKDDRE 147
              ++ +E ++  L R D E     + L + + L   + + + D DS     N+  K  R+
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150

Query: 148  RGEGQEPAFSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLN 207
             GE  E   + L     S++ + E + +   E     V+ +    D+     E   +++ 
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQE-----VTVLKKALDEETRSHEAQVQEMR 1205

Query: 208  SGDNLIVEEAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVL 267
                  VEE  ++L  F  +    L +    L++++  ++ E   L    +  E +   L
Sbjct: 1206 QKHAQAVEELTEQLEQF-KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264

Query: 268  ESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEE 327
            E+ + +LQ       +    LN  + ++   V S    V G  +   G  I + A+    
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVES----VTGMLNEAEGKAIKL-AKDVAS 1319

Query: 328  MNAELEENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQ 387
            ++++L++ +EL Q      E+ RQ    V+T+  +L+ E  S  +Q+ +E    + ++  
Sbjct: 1320 LSSQLQDTQELLQ------EETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372

Query: 388  FSVLYNESLQLKAHL-DEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLA 446
             S L  +    K  L D A T+     G  + Q E+   +    +++      +LE T  
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI--ENLTQQYEEKAAAYDKLEKTKN 1430

Query: 447  QVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQS 506
            ++++E + L ++ +             R+   L++  +N + +   E  R + + RE ++
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490

Query: 507  DLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDE 566
                  L    AL ++  + E+ +     LK + EDL S       S++D       ++ 
Sbjct: 1491 KA----LSLARALEEALEAKEELERTNKMLKAEMEDLVS-------SKDDVG-----KNV 1534

Query: 567  EERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEII 626
             E E+ +R  E + E  + + +E E E Q  ++++   +      KG+ +          
Sbjct: 1535 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE---------- 1584

Query: 627  KQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLED 686
            + L+   ++ +E +++++  L  Y +  +++R +  L AA KK       L   LKDLE 
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK------LEGDLKDLEL 1638

Query: 687  KEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQN 746
            +     K    E+A++++R ++ Q++  Q++L  A+   + + +      +  + ++   
Sbjct: 1639 QADSAIK--GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1696

Query: 747  IRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLE 806
            ++L + L   + A               K    EKEELA+++ +  +  +A     R+LE
Sbjct: 1697 MQLQEDLAAAERAR--------------KQADLEKEELAEELASSLSGRNALQDEKRRLE 1742

Query: 807  EKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQK 856
             +   L+  +   E+E G      +  ++   +A QL+++L  +   AQK
Sbjct: 1743 ARIAQLEEEL---EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789



 Score =  106 bits (265), Expect = 9e-23
 Identities = 156/811 (19%), Positives = 334/811 (41%), Gaps = 107/811 (13%)

Query: 27   DSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATD 86
            D G  +E +K   +  T +      + + ++  E+   ++A+++E R H  +++  +   
Sbjct: 1150 DLGEELEALKTE-LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208

Query: 87   DASLLIVNRYWSQFDE-NIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDD 145
              ++  +     QF      +   +  LE+   DL  E + L          + QE +  
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL--------GQAKQEVEHK 1260

Query: 146  RERGEGQEPAFSFLATLASSSSEEMESQ---LQERVESSRRAVSQIVTVYDKLQEKVELL 202
            +++ E Q        +    +  E+  +   LQ  VES    +++      KL + V  L
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320

Query: 203  SRKLNSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAES 262
            S +L     L+ EE  Q+LN  ++ +  +L+E  + LQ++     +    L+  + T   
Sbjct: 1321 SSQLQDTQELLQEETRQKLN--VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNI 1378

Query: 263  RVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINA 322
            ++S  +  + D    ++ + + ++R  + +  + ++   K      A       T     
Sbjct: 1379 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA-----AAYDKLEKTKNRLQ 1433

Query: 323  RKFEEMNAELEENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYR 382
            ++ +++  +L+  ++L  N    LEK ++ F+++  + + +  +     ++   E  E  
Sbjct: 1434 QELDDLVVDLDNQRQLVSN----LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489

Query: 383  CMQSQFSVLYNESLQLKAHLDEARTLLHGTR----------GTHQHQVELIERDEVSLHK 432
                  +    E+L+ K  L+    +L              G + H++E  +R   +  +
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549

Query: 433  KLRTEVIQLEDTL-----AQVRKEYEM--LRIEFEQTLAANEQAGPINREMRHLISSLQN 485
            +++T++ +LED L     A++R E  M  L+ +FE+ L A ++    N E R  +   Q 
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ---NEEKRRQLQR-QL 1605

Query: 486  HNHQLKGEVLRYKRKLREA-----QSDLNKTRLRSGSAL------------LQSQSSTED 528
            H ++ + E  R +R L  A     + DL    L++ SA+            LQ+Q     
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665

Query: 529  PKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREK-- 586
             + E A    D    +++ +  KA   +A+ ++ + D    ER R++ + E+E   E+  
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725

Query: 587  -----EKEREREKQKLKESEKERDSAKDKEKGKHD---DGRKKEAEIIKQLKIELKKAQE 638
                     + EK++L+    + +   ++E+G  +   D  +K  +  +QL  EL   + 
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785

Query: 639  SQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSK------------AELEDLRQR------ 680
            + ++ +          KE R K+  M    KSK            A+LE+  ++      
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845

Query: 681  --LKDLEDKEKK---------ENKKMAD------EDALRKIRAVEEQIEYLQKKLAMAKQ 723
               K L+ K+KK         + +KMA+      E    +++ ++ Q+E  +++      
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905

Query: 724  EEEALLSEMDVTGQAFEDMQEQNIRLMQQLR 754
                L  E+D   ++ E M  +   L  +LR
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSKLR 1936



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 159/717 (22%), Positives = 296/717 (41%), Gaps = 118/717 (16%)

Query: 283  KREQRLN------RHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNA---ELE 333
            KR+Q+L       R+ A  L+  N + ++++     L   T     R+ EEM A   EL+
Sbjct: 815  KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVT-----RQEEEMQAKEDELQ 869

Query: 334  ENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCM-----QSQF 388
            + KE  Q    EL++L Q   ++T +   L+ +L++  E +  E  E R       Q   
Sbjct: 870  KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE-LYAEAEEMRVRLAAKKQELE 928

Query: 389  SVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIE--------RDEVSLHK-------- 432
             +L+    +L+   D  + L    +   Q  ++L E        R ++ L K        
Sbjct: 929  EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 988

Query: 433  KLRTEVIQLEDTLAQVRKEYEML--RIEFEQTLAANEQAGPIN-----REMRHLISSLQ- 484
            KL  E++ ++D   ++ KE ++L  RI    T  A E+    N      +   +IS L+ 
Sbjct: 989  KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1048

Query: 485  --NHNHQLKGEVLRYKRKLREAQSDLNK--TRLRSGSALLQSQSSTEDPKDEPAELKPDS 540
                  + + E+ + KRKL    SD ++    L++  A L+ Q + ++ + + A  + D 
Sbjct: 1049 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD 1108

Query: 541  EDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREKEKE----------- 589
            E ++ +++A K  +E    I   +++ + ER  R K  +++R+  +E E           
Sbjct: 1109 E-IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1167

Query: 590  --------REREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQK 641
                    R + +Q++   +K  D      + +  + R+K A+ +++L  +L    E  K
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL----EQFK 1223

Query: 642  EMKLLLDMYRSA-PKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDA 700
              K  LD  +    KE  D    +    ++K E+E    + K LE + ++   K +D + 
Sbjct: 1224 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE---HKKKKLEAQVQELQSKCSDGER 1280

Query: 701  LR-----KIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLRE 755
             R     K+  ++ ++E +   L  A+ +   L  ++       +D QE    L ++ R+
Sbjct: 1281 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL---LQEETRQ 1337

Query: 756  KDDANFKLMSERIKSNQIHKLLKEE---KEELADQVLTLKTQVD---AQLQ----VVRKL 805
            K + + KL     + N +   L EE   K+ L   + TL  Q+     +LQ     V  L
Sbjct: 1338 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1397

Query: 806  EEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLE------------- 852
            EE +   Q  I    ++   +  A +  ++      Q  DDL   L+             
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1457

Query: 853  ------LAQK-----KLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKK 898
                  LA++     K  D +D     +  KE    +  RA E+    + +LE T K
Sbjct: 1458 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1514



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 123/659 (18%), Positives = 271/659 (41%), Gaps = 73/659 (11%)

Query: 48   IRTLQTKNRKLAEMLDQRQAIEDELREHIEKLE------RRQATDDASLL-IVNRYWSQF 100
            +R L+ +   L + LD+    +  L  HI  L       +++  D AS +  +     +F
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404

Query: 101  DENIRIILKRYDLEQGLGDLLTERKALVVPEPEP---DSDSNQERKDDRERGEGQ-EPAF 156
             + I  + ++Y+ +    D L + K  +  E +    D D+ ++   + E+ + + +   
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464

Query: 157  SFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEE 216
            +    ++S  ++E +    E  E   +A+S    + + L+ K EL         N +++ 
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL------ERTNKMLKA 1518

Query: 217  AVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQW 276
             +++L S        + EL    ++  R +  +  ++++++E  E  +   E     L+ 
Sbjct: 1519 EMEDLVSSKDDVGKNVHEL----EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEV 1574

Query: 277  DIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENK 336
            ++  ++ +     R L    E+   K  ++                R+  E   ELE+ +
Sbjct: 1575 NMQALKGQ---FERDLQARDEQNEEKRRQLQ---------------RQLHEYETELEDER 1616

Query: 337  ELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESL 396
            +         +KL  D ++       L+++  SA++   +   + R +Q+Q      E  
Sbjct: 1617 KQRALAAAAKKKLEGDLKD-------LELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669

Query: 397  QLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLR 456
              +A  DE    +  T   ++ + + +E D + L + L       E    Q   E E L 
Sbjct: 1670 DARASRDE----IFATAKENEKKAKSLEADLMQLQEDLAAA----ERARKQADLEKEELA 1721

Query: 457  IEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSD---LNKTRL 513
             E   +L+         R +   I+ L+    + +G +     ++R+A      L+    
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781

Query: 514  RSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERER 573
               S   +++S+ +  + +  EL+    ++     +   S   A E K  + EE+ E+E 
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841

Query: 574  REKEREREREREKEKEREREKQKLKESEKERDSAKD-KEKGKHDDGRKKEAEIIKQLKIE 632
            REK+   +  ++K+K   + K+ L + E ER  A+  KE+ +  + R      +KQLK +
Sbjct: 1842 REKQAATKSLKQKDK---KLKEILLQVEDERKMAEQYKEQAEKGNAR------VKQLKRQ 1892

Query: 633  LKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKE 691
            L++A+E  + +        +  K QR+  +   + +    E+  L+ +L+    +E  +
Sbjct: 1893 LEEAEEESQRIN------ANRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQETSQ 1945



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 80/363 (22%), Positives = 183/363 (50%), Gaps = 24/363 (6%)

Query: 573  RREKERE-REREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKI 631
            R+E+E + +E E +K KER+++ +   +  +++ S   +EK    +  + E E+  + + 
Sbjct: 856  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915

Query: 632  ELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKA-ELEDLRQRLKDLEDKEKK 690
               +    ++E++ +L    +  +E+ D+ Q + AE+K  A ++ DL ++L+  E++  +
Sbjct: 916  MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE--EEEAAR 973

Query: 691  ENKKMADEDALRKIRAVEEQIEYL---QKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNI 747
            +  ++    A  KI+ +E++I  +     KL+  ++  E  +S++  T  A E+ + +N+
Sbjct: 974  QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL-TTNLAEEEEKAKNL 1032

Query: 748  RLMQQLREK--DDANFKLMSERIKSNQIHKL---LKEEKEELADQVLTLKTQVDAQLQVV 802
              ++   E    +   +L  E     ++ KL   L+ +  +  +Q+  L+ Q+ A+L++ 
Sbjct: 1033 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI-AELKM- 1090

Query: 803  RKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDL---KAQLELAQKKLH 859
             +L +KE  LQ+ +   + E+  +  AL+  +      + L +DL   +A    A+K+  
Sbjct: 1091 -QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149

Query: 860  DFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETT---KKPDNVPKCDEILMEEIKDY 916
            D  +E+ E   T+ +D  +    Q+++ R +R+ E T   K  D   +  E  ++E++  
Sbjct: 1150 DLGEEL-EALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1207

Query: 917  KAR 919
             A+
Sbjct: 1208 HAQ 1210


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  132 bits (331), Expect = 2e-30
 Identities = 195/888 (21%), Positives = 378/888 (42%), Gaps = 105/888 (11%)

Query: 51   LQTKNRKLAEMLDQRQAIEDELRE----HIEKLERRQATDDASLLIVNRYWSQFDENIRI 106
            +Q K  +L +  +++Q  E+EL+E    H +  E +    +        Y    +  +R+
Sbjct: 854  MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL 913

Query: 107  ILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSS 166
              K+ +LE    ++L E +A +    E + D  Q+ + +R++               +  
Sbjct: 914  AAKKQELE----EILHEMEARL----EEEEDRGQQLQAERKK--------------MAQQ 951

Query: 167  SEEMESQLQERVESSRRAVSQIVTV---YDKLQEKVELLSRKLN--SGDNLIVEEAVQEL 221
              ++E QL+E   + ++   + VT      KL++++ ++  + N  S +  ++EE + +L
Sbjct: 952  MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1011

Query: 222  NSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKI 281
             + LA+E  + + LT  L+ KH +M    S+L+ +++  E     LE +   L+ D    
Sbjct: 1012 TTNLAEEEEKAKNLTK-LKNKHESM---ISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067

Query: 282  RKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITIN--ARKFEEMNAELEENKELA 339
             ++   L   +AE+  ++  K  ++  A + L       N   +K  E+   + + +E  
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127

Query: 340  QNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLK 399
             +      K  +   ++  + E LK EL   ++    +  E R  + Q      E   LK
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ-QELRAKREQ------EVTVLK 1180

Query: 400  AHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEF 459
              LDE       TR +H+ QV+ + +      ++L  ++ Q +   A + K  + L  E 
Sbjct: 1181 KALDEE------TR-SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKEN 1233

Query: 460  EQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSAL 519
                      G   +E+ H    L+    +L+ +    +R    A+++LN    +  + +
Sbjct: 1234 ADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER----ARAELNDKVHKLQNEV 1289

Query: 520  LQSQSSTEDPKDEPAELKPDSEDLSSQ-SSASKASQEDANE-----IKSKRDEEERERER 573
                    + + +  +L  D   LSSQ     +  QE+  +      K ++ EEER   +
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349

Query: 574  REKEREREREREKEKEREREKQKLKESEKE-RDSAKDKEKGKHDDGRKKEAEIIKQL--- 629
             + + E E ++  E+       +L +S+K+ +D A   E    ++G+K+  + I+ L   
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVE--ALEEGKKRFQKEIENLTQQ 1407

Query: 630  ---------KIELKKAQESQKEMKLLLD------MYRSAPKEQRDKVQLMAAEKKSKAEL 674
                     K+E  K +  Q+   L++D      +  +  K+QR   QL+A EK   ++ 
Sbjct: 1408 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1467

Query: 675  EDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDV 734
             D R R +   +  +KE K ++   AL +    +E++E   K   M K E E L+S  D 
Sbjct: 1468 ADERDRAE--AEAREKETKALSLARALEEALEAKEELERTNK---MLKAEMEDLVSSKDD 1522

Query: 735  TGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQ 794
             G+   ++++    L  Q+ E      K   E ++     +  ++ K  L   +  LK Q
Sbjct: 1523 VGKNVHELEKSKRALETQMEE-----MKTQLEELEDEL--QATEDAKLRLEVNMQALKGQ 1575

Query: 795  VDAQLQV-VRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAA---QLADDLKAQ 850
             +  LQ    + EEK   LQ  +   E EL       +  K++A+ AA   +L  DLK  
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELE------DERKQRALAAAAKKKLEGDLK-D 1628

Query: 851  LELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKK 898
            LEL        ++E ++     +  M +F+R  ED    R ++  T K
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAK 1676



 Score =  108 bits (270), Expect = 2e-23
 Identities = 166/830 (20%), Positives = 353/830 (42%), Gaps = 91/830 (10%)

Query: 47   DIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATD-----------DASLLIVNR 95
            ++  L+ K+  +   L+ R   E++ R+ +EKL+R+   D            A +  +  
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083

Query: 96   YWSQFDENIRIILKRYDLEQGL-GDLLTERKALV--VPEPEPDSDS-----NQERKDDRE 147
              ++ +E ++  L R D E     + L + + L   + + + D DS     N+  K  R+
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143

Query: 148  RGEGQEPAFSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLN 207
             GE  E   + L     S++ + E + +   E     V+ +    D+     E   +++ 
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQE-----VTVLKKALDEETRSHEAQVQEMR 1198

Query: 208  SGDNLIVEEAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVL 267
                  VEE  ++L  F  +    L +    L++++  ++ E   L    +  E +   L
Sbjct: 1199 QKHAQAVEELTEQLEQF-KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257

Query: 268  ESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEE 327
            E+ + +LQ       +    LN  + ++   V S    V G  +   G  I + A+    
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVES----VTGMLNEAEGKAIKL-AKDVAS 1312

Query: 328  MNAELEENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQ 387
            ++++L++ +EL Q      E+ RQ    V+T+  +L+ E  S  +Q+ +E    + ++  
Sbjct: 1313 LSSQLQDTQELLQ------EETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365

Query: 388  FSVLYNESLQLKAHL-DEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLA 446
             S L  +    K  L D A T+     G  + Q E+   +    +++      +LE T  
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI--ENLTQQYEEKAAAYDKLEKTKN 1423

Query: 447  QVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQS 506
            ++++E + L ++ +             R+   L++  +N + +   E  R + + RE ++
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483

Query: 507  DLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDE 566
                  L    AL ++  + E+ +     LK + EDL S       S++D       ++ 
Sbjct: 1484 KA----LSLARALEEALEAKEELERTNKMLKAEMEDLVS-------SKDDVG-----KNV 1527

Query: 567  EERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEII 626
             E E+ +R  E + E  + + +E E E Q  ++++   +      KG+ +          
Sbjct: 1528 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE---------- 1577

Query: 627  KQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLED 686
            + L+   ++ +E +++++  L  Y +  +++R +  L AA KK       L   LKDLE 
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK------LEGDLKDLEL 1631

Query: 687  KEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQN 746
            +     K    E+A++++R ++ Q++  Q++L  A+   + + +      +  + ++   
Sbjct: 1632 QADSAIK--GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL 1689

Query: 747  IRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLE 806
            ++L + L   + A               K    EKEELA+++ +  +  +A     R+LE
Sbjct: 1690 MQLQEDLAAAERAR--------------KQADLEKEELAEELASSLSGRNALQDEKRRLE 1735

Query: 807  EKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQK 856
             +   L+  +   E+E G      +  ++   +A QL+++L  +   AQK
Sbjct: 1736 ARIAQLEEEL---EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782



 Score =  106 bits (265), Expect = 9e-23
 Identities = 156/811 (19%), Positives = 334/811 (41%), Gaps = 107/811 (13%)

Query: 27   DSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATD 86
            D G  +E +K   +  T +      + + ++  E+   ++A+++E R H  +++  +   
Sbjct: 1143 DLGEELEALKTE-LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201

Query: 87   DASLLIVNRYWSQFDE-NIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDD 145
              ++  +     QF      +   +  LE+   DL  E + L          + QE +  
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL--------GQAKQEVEHK 1253

Query: 146  RERGEGQEPAFSFLATLASSSSEEMESQ---LQERVESSRRAVSQIVTVYDKLQEKVELL 202
            +++ E Q        +    +  E+  +   LQ  VES    +++      KL + V  L
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313

Query: 203  SRKLNSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAES 262
            S +L     L+ EE  Q+LN  ++ +  +L+E  + LQ++     +    L+  + T   
Sbjct: 1314 SSQLQDTQELLQEETRQKLN--VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNI 1371

Query: 263  RVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINA 322
            ++S  +  + D    ++ + + ++R  + +  + ++   K      A       T     
Sbjct: 1372 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA-----AAYDKLEKTKNRLQ 1426

Query: 323  RKFEEMNAELEENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYR 382
            ++ +++  +L+  ++L  N    LEK ++ F+++  + + +  +     ++   E  E  
Sbjct: 1427 QELDDLVVDLDNQRQLVSN----LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482

Query: 383  CMQSQFSVLYNESLQLKAHLDEARTLLHGTR----------GTHQHQVELIERDEVSLHK 432
                  +    E+L+ K  L+    +L              G + H++E  +R   +  +
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542

Query: 433  KLRTEVIQLEDTL-----AQVRKEYEM--LRIEFEQTLAANEQAGPINREMRHLISSLQN 485
            +++T++ +LED L     A++R E  M  L+ +FE+ L A ++    N E R  +   Q 
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ---NEEKRRQLQR-QL 1598

Query: 486  HNHQLKGEVLRYKRKLREA-----QSDLNKTRLRSGSAL------------LQSQSSTED 528
            H ++ + E  R +R L  A     + DL    L++ SA+            LQ+Q     
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658

Query: 529  PKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREK-- 586
             + E A    D    +++ +  KA   +A+ ++ + D    ER R++ + E+E   E+  
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718

Query: 587  -----EKEREREKQKLKESEKERDSAKDKEKGKHD---DGRKKEAEIIKQLKIELKKAQE 638
                     + EK++L+    + +   ++E+G  +   D  +K  +  +QL  EL   + 
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778

Query: 639  SQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSK------------AELEDLRQR------ 680
            + ++ +          KE R K+  M    KSK            A+LE+  ++      
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838

Query: 681  --LKDLEDKEKK---------ENKKMAD------EDALRKIRAVEEQIEYLQKKLAMAKQ 723
               K L+ K+KK         + +KMA+      E    +++ ++ Q+E  +++      
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898

Query: 724  EEEALLSEMDVTGQAFEDMQEQNIRLMQQLR 754
                L  E+D   ++ E M  +   L  +LR
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSKLR 1929



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 159/717 (22%), Positives = 296/717 (41%), Gaps = 118/717 (16%)

Query: 283  KREQRLN------RHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNA---ELE 333
            KR+Q+L       R+ A  L+  N + ++++     L   T     R+ EEM A   EL+
Sbjct: 808  KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVT-----RQEEEMQAKEDELQ 862

Query: 334  ENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCM-----QSQF 388
            + KE  Q    EL++L Q   ++T +   L+ +L++  E +  E  E R       Q   
Sbjct: 863  KTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE-LYAEAEEMRVRLAAKKQELE 921

Query: 389  SVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIE--------RDEVSLHK-------- 432
             +L+    +L+   D  + L    +   Q  ++L E        R ++ L K        
Sbjct: 922  EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK 981

Query: 433  KLRTEVIQLEDTLAQVRKEYEML--RIEFEQTLAANEQAGPIN-----REMRHLISSLQ- 484
            KL  E++ ++D   ++ KE ++L  RI    T  A E+    N      +   +IS L+ 
Sbjct: 982  KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1041

Query: 485  --NHNHQLKGEVLRYKRKLREAQSDLNK--TRLRSGSALLQSQSSTEDPKDEPAELKPDS 540
                  + + E+ + KRKL    SD ++    L++  A L+ Q + ++ + + A  + D 
Sbjct: 1042 RLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDD 1101

Query: 541  EDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREKEKE----------- 589
            E ++ +++A K  +E    I   +++ + ER  R K  +++R+  +E E           
Sbjct: 1102 E-IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1160

Query: 590  --------REREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQK 641
                    R + +Q++   +K  D      + +  + R+K A+ +++L  +L    E  K
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL----EQFK 1216

Query: 642  EMKLLLDMYRSA-PKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDA 700
              K  LD  +    KE  D    +    ++K E+E    + K LE + ++   K +D + 
Sbjct: 1217 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE---HKKKKLEAQVQELQSKCSDGER 1273

Query: 701  LR-----KIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLRE 755
             R     K+  ++ ++E +   L  A+ +   L  ++       +D QE    L ++ R+
Sbjct: 1274 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL---LQEETRQ 1330

Query: 756  KDDANFKLMSERIKSNQIHKLLKEE---KEELADQVLTLKTQVD---AQLQ----VVRKL 805
            K + + KL     + N +   L EE   K+ L   + TL  Q+     +LQ     V  L
Sbjct: 1331 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEAL 1390

Query: 806  EEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLE------------- 852
            EE +   Q  I    ++   +  A +  ++      Q  DDL   L+             
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1450

Query: 853  ------LAQK-----KLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKK 898
                  LA++     K  D +D     +  KE    +  RA E+    + +LE T K
Sbjct: 1451 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1507



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 123/659 (18%), Positives = 271/659 (41%), Gaps = 73/659 (11%)

Query: 48   IRTLQTKNRKLAEMLDQRQAIEDELREHIEKLE------RRQATDDASLL-IVNRYWSQF 100
            +R L+ +   L + LD+    +  L  HI  L       +++  D AS +  +     +F
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397

Query: 101  DENIRIILKRYDLEQGLGDLLTERKALVVPEPEP---DSDSNQERKDDRERGEGQ-EPAF 156
             + I  + ++Y+ +    D L + K  +  E +    D D+ ++   + E+ + + +   
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457

Query: 157  SFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEE 216
            +    ++S  ++E +    E  E   +A+S    + + L+ K EL         N +++ 
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL------ERTNKMLKA 1511

Query: 217  AVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQW 276
             +++L S        + EL    ++  R +  +  ++++++E  E  +   E     L+ 
Sbjct: 1512 EMEDLVSSKDDVGKNVHEL----EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEV 1567

Query: 277  DIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENK 336
            ++  ++ +     R L    E+   K  ++                R+  E   ELE+ +
Sbjct: 1568 NMQALKGQ---FERDLQARDEQNEEKRRQLQ---------------RQLHEYETELEDER 1609

Query: 337  ELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESL 396
            +         +KL  D ++       L+++  SA++   +   + R +Q+Q      E  
Sbjct: 1610 KQRALAAAAKKKLEGDLKD-------LELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662

Query: 397  QLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLR 456
              +A  DE    +  T   ++ + + +E D + L + L       E    Q   E E L 
Sbjct: 1663 DARASRDE----IFATAKENEKKAKSLEADLMQLQEDLAAA----ERARKQADLEKEELA 1714

Query: 457  IEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSD---LNKTRL 513
             E   +L+         R +   I+ L+    + +G +     ++R+A      L+    
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774

Query: 514  RSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERER 573
               S   +++S+ +  + +  EL+    ++     +   S   A E K  + EE+ E+E 
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834

Query: 574  REKEREREREREKEKEREREKQKLKESEKERDSAKD-KEKGKHDDGRKKEAEIIKQLKIE 632
            REK+   +  ++K+K   + K+ L + E ER  A+  KE+ +  + R      +KQLK +
Sbjct: 1835 REKQAATKSLKQKDK---KLKEILLQVEDERKMAEQYKEQAEKGNAR------VKQLKRQ 1885

Query: 633  LKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKE 691
            L++A+E  + +        +  K QR+  +   + +    E+  L+ +L+    +E  +
Sbjct: 1886 LEEAEEESQRIN------ANRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQETSQ 1938



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 80/363 (22%), Positives = 183/363 (50%), Gaps = 24/363 (6%)

Query: 573  RREKERE-REREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKI 631
            R+E+E + +E E +K KER+++ +   +  +++ S   +EK    +  + E E+  + + 
Sbjct: 849  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908

Query: 632  ELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKA-ELEDLRQRLKDLEDKEKK 690
               +    ++E++ +L    +  +E+ D+ Q + AE+K  A ++ DL ++L+  E++  +
Sbjct: 909  MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE--EEEAAR 966

Query: 691  ENKKMADEDALRKIRAVEEQIEYL---QKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNI 747
            +  ++    A  KI+ +E++I  +     KL+  ++  E  +S++  T  A E+ + +N+
Sbjct: 967  QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL-TTNLAEEEEKAKNL 1025

Query: 748  RLMQQLREK--DDANFKLMSERIKSNQIHKL---LKEEKEELADQVLTLKTQVDAQLQVV 802
              ++   E    +   +L  E     ++ KL   L+ +  +  +Q+  L+ Q+ A+L++ 
Sbjct: 1026 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI-AELKM- 1083

Query: 803  RKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDL---KAQLELAQKKLH 859
             +L +KE  LQ+ +   + E+  +  AL+  +      + L +DL   +A    A+K+  
Sbjct: 1084 -QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142

Query: 860  DFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETT---KKPDNVPKCDEILMEEIKDY 916
            D  +E+ E   T+ +D  +    Q+++ R +R+ E T   K  D   +  E  ++E++  
Sbjct: 1143 DLGEEL-EALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1200

Query: 917  KAR 919
             A+
Sbjct: 1201 HAQ 1203


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score =  126 bits (316), Expect = 1e-28
 Identities = 186/890 (20%), Positives = 377/890 (42%), Gaps = 129/890 (14%)

Query: 51   LQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDENIRIILKR 110
            L  K RKL +   + +   D+L   + K+E+ +   +  +  +    +  DE I  + K 
Sbjct: 940  LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK- 998

Query: 111  YDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSSSEEM 170
                        E+KAL         +++Q+  DD +  E +        T A +  E+ 
Sbjct: 999  ------------EKKAL--------QEAHQQTLDDLQMEEDKVNTL----TKAKTKLEQQ 1034

Query: 171  ESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQENM 230
               L+  +E  ++    +     KL+  +     KL     +  E   Q+LN  L ++  
Sbjct: 1035 VDDLEGSLEQEKKLCMDLERAKRKLEGDL-----KLAQESTMDTENDKQQLNEKLKKKEF 1089

Query: 231  RLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNR 290
             +  L   ++++     Q    LQ K++  ++R+  LE  I+  +    K  K+   L+R
Sbjct: 1090 EMSNLQGKIEDEQALAIQ----LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR 1145

Query: 291  HLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLR 350
             L E+ ER+   G           G T           +A++E NK+    R  E +K+R
Sbjct: 1146 ELEEISERLEEAG-----------GAT-----------SAQIEMNKK----REAEFQKMR 1179

Query: 351  QDFEEVTTQNEKLKVELRSAVEQVVKETPE-YRCMQSQFSVLYNESLQLKAHLDEARTLL 409
            +D EE T Q+E     LR      V E  E    +Q     L  E  +LK  +++  +  
Sbjct: 1180 RDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLAS-- 1237

Query: 410  HGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVR-KEYEMLRIEFE---QTLAA 465
                      +E + + + +  K  RT    LED L++++ KE E  R+  E   Q    
Sbjct: 1238 ---------NMETVSKAKANFEKMCRT----LEDQLSEIKTKEEEQQRLINELSAQKARL 1284

Query: 466  NEQAGPINREMRH---LISSLQNHNHQLKGEVLRYKRKLRE---AQSDLNKT--RLRSGS 517
            + ++G  +R++     ++S L         ++   KR+L E   A+S L       R   
Sbjct: 1285 HTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDC 1344

Query: 518  ALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQE-DANEIKSKRDEEERERERREK 576
             LL+ Q   E+ ++  AEL+      +S+ +  +   E DA +   + +E +++  +R +
Sbjct: 1345 DLLREQ--YEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1402

Query: 577  EREREREREKEK--EREREKQKLKES------EKERDSAK----DKEKGKHDDGRKKEAE 624
            + E   E    K    E+ KQ+L+        + ER +A     DK++   D    +  +
Sbjct: 1403 DAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQ 1462

Query: 625  IIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKS-KAELEDLRQRL-- 681
              ++ + EL+ +Q+  + +   L   ++A +E  D ++ +  E K+ + E+ DL +++  
Sbjct: 1463 KYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAE 1522

Query: 682  --KDLEDKEK--------KENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSE 731
              K + + EK        K   + + E+A   +   E +I  +Q +L   K E +  ++E
Sbjct: 1523 GGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAE 1582

Query: 732  MDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTL 791
             D   +  + ++  ++R+++ ++   DA  +  ++ ++   I K ++ +  E+  Q+   
Sbjct: 1583 KD---EELDQLKRNHLRVVESMQSTLDAEIRSRNDALR---IKKKMEGDLNEMEIQLNHA 1636

Query: 792  KTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQL 851
              Q    L+ +R  +      Q ++    +      + L M +R+A       ++L+A L
Sbjct: 1637 NRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASL 1696

Query: 852  ELAQKKLHDFQDEIVENSV------TKEKDMFNFKRAQE-DISRLRRKLE 894
            E  ++     + E+++ S       T+   + N K+  E DIS+++ ++E
Sbjct: 1697 ERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEME 1746



 Score =  116 bits (290), Expect = 1e-25
 Identities = 183/935 (19%), Positives = 387/935 (41%), Gaps = 105/935 (11%)

Query: 20   EKKAAVEDSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKL 79
            EKKA  E    T++ +++      EE  + TL     KL + +D  +   ++ ++    L
Sbjct: 999  EKKALQEAHQQTLDDLQM------EEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDL 1052

Query: 80   ER--RQATDDASLLIVNRYWSQFD-ENIRIILKRYDLEQG-LGDLLTERKALVVPEPEPD 135
            ER  R+   D  L   +   ++ D + +   LK+ + E   L   + + +AL +   +  
Sbjct: 1053 ERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKI 1112

Query: 136  SDSNQERKDDRERGEGQEPAFSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKL 195
             +     ++  E  E +  + +      S  S E+E ++ ER+E +  A S  + +  K 
Sbjct: 1113 KELQARIEELEEEIEAERASRAKAEKQRSDLSRELE-EISERLEEAGGATSAQIEMNKKR 1171

Query: 196  QEKVELLSRKLNSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQ- 254
            + + + + R L     L  E     L    A     L E  D LQ   + + +E S+L+ 
Sbjct: 1172 EAEFQKMRRDLEES-TLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKM 1230

Query: 255  ------SKVETAESRVSVLESMIDDLQWDIDKIRKREQ--------------RLNRHLAE 294
                  S +ET     +  E M   L+  + +I+ +E+              RL+    E
Sbjct: 1231 EINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGE 1290

Query: 295  VLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDFE 354
               +++ K   V    S L  G      ++ EE+  +LEE  +        L+  R D +
Sbjct: 1291 FSRQLDEKDAMV----SQLSRGKQAFT-QQIEELKRQLEEETKAKSTLAHALQSARHDCD 1345

Query: 355  EVTTQNEK---LKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHG 411
             +  Q E+    K EL+  + +   E  ++R           +++Q    L+EA+  L  
Sbjct: 1346 LLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYE------TDAIQRTEELEEAKKKLAQ 1399

Query: 412  TRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGP 471
                 +  VE +            ++   LE T  +++ E E L I+ E++ AA      
Sbjct: 1400 RLQDAEEHVEAVN-----------SKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDK 1448

Query: 472  INREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKD 531
              R    +++  +    + + E+   +++ R   ++L K +    +A  +S    E  K 
Sbjct: 1449 KQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVK----NAYEESLDHLETLKR 1504

Query: 532  EPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREKEK--E 589
            E   L+ +  DL+ Q +       +  ++K + D E+ E +   +E E   E E+ K   
Sbjct: 1505 ENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILR 1564

Query: 590  REREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDM 649
             + E  ++K     + + KD+E    D  ++    +++ ++  L        E++   D 
Sbjct: 1565 IQLELNQVKSEIDRKIAEKDEEL---DQLKRNHLRVVESMQSTL------DAEIRSRNDA 1615

Query: 650  YRSAPKEQRD----KVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIR 705
             R   K + D    ++QL  A +++   L +LR     L+D +      +  +DA+R   
Sbjct: 1616 LRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQ------LHLDDAIRGQD 1669

Query: 706  AVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMS 765
             ++EQ+  ++++  + + E E L + ++ T +  +  +++ +   ++++     N  L++
Sbjct: 1670 DLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLIN 1729

Query: 766  ERIK--------SNQIHKLLKEEK--EELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSN 815
             + K          ++  +++E +  EE A + +T    +  +L+  +        ++ N
Sbjct: 1730 TKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1789

Query: 816  IGTGEKELGLRTQ-----ALEMNKRKAMEAAQLADDLKAQLELAQKK-------LHDFQD 863
            +    K+L LR       AL+  K++  +      +L++++E  QK        L   + 
Sbjct: 1790 MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHER 1849

Query: 864  EIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKK 898
             + E +   E+D  N  R Q+ + +L+ K++  K+
Sbjct: 1850 RVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKR 1884



 Score =  106 bits (264), Expect = 1e-22
 Identities = 149/771 (19%), Positives = 341/771 (44%), Gaps = 84/771 (10%)

Query: 57   KLAEMLDQRQAIEDELREHIEKLERRQATDD--ASLLIVNRYWSQFDENIRIILKRYDLE 114
            +L E +D  Q ++ +L +  EK E +   +D  +++  V++  + F++  R       LE
Sbjct: 1206 ELGEQIDSLQRVKQKLEK--EKSELKMEINDLASNMETVSKAKANFEKMCRT------LE 1257

Query: 115  QGLGDLLT---ERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSSSEEME 171
              L ++ T   E++ L+       +  + E  +   + + ++   S L+    + ++++E
Sbjct: 1258 DQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIE 1317

Query: 172  SQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVE--EAVQELNSFLAQEN 229
             +L+ ++E   +A S +       +   +LL  +         E    + + NS +AQ  
Sbjct: 1318 -ELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWR 1376

Query: 230  MRLQ----ELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKRE 285
             + +    + T+ L+E  + ++Q     +  VE   S+ + LE     LQ +++ +    
Sbjct: 1377 TKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDV 1436

Query: 286  QRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCE 345
            +R N      L++      KV                +K+EE  AELE +++ +++   E
Sbjct: 1437 ERSNAACI-ALDKKQRNFDKVLAEWK-----------QKYEETQAELEASQKESRSLSTE 1484

Query: 346  LEKLRQDFEE-------VTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQL 398
            L K++  +EE       +  +N+ L+ E+    EQ+ +       ++     L +E  +L
Sbjct: 1485 LFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSEL 1544

Query: 399  KAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEY----EM 454
            +  L+EA   L    G    ++  I+ +   +  ++  ++ + ++ L Q+++ +    E 
Sbjct: 1545 QTSLEEAEASLEHEEG----KILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVES 1600

Query: 455  LRIEFEQTLAANEQAGPINREMRHLISSLQ---NHNHQLKGEVLRYKRKLREAQSDLNKT 511
            ++   +  + +   A  I ++M   ++ ++   NH ++   E L   R LR  Q  L  T
Sbjct: 1601 MQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEAL---RNLRNTQGILKDT 1657

Query: 512  RLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERER 571
            +L    A+       +D K++ A ++  +  + ++    +AS E     +   ++E  + 
Sbjct: 1658 QLHLDDAI----RGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDA 1713

Query: 572  ERREKERERER------EREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGR------ 619
              R +    +       +++ E +  + + ++++  +E  +A++K K    D        
Sbjct: 1714 SERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEEL 1773

Query: 620  KKEAEIIKQLKIELKKAQESQKEMKLLLD----MYRSAPKEQRDKVQLMAAEKKSKAELE 675
            KKE +    L+   K  +++ K+++L LD    +     K+Q  K++    E +S+ E E
Sbjct: 1774 KKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESE 1833

Query: 676  DLR--QRLKDLEDKEK--KENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSE 731
                 + +K L   E+  KE     +ED  + I  +++ ++ LQ K+   K++ E    +
Sbjct: 1834 QKHNVEAVKGLRKHERRVKELTYQTEEDR-KNILRLQDLVDKLQTKVKAYKRQAEEAEEQ 1892

Query: 732  MDVTGQAFEDMQEQNIRLMQQLREKDD-ANFKLMSERIKSNQIH-KLLKEE 780
             +V    F  +Q +    +++ +E+ D A  ++   R+KS ++H K++ EE
Sbjct: 1893 SNVNLAKFRKLQHE----LEEAKERADIAESQVNKLRVKSREVHTKVISEE 1939



 Score = 97.4 bits (241), Expect = 6e-20
 Identities = 129/641 (20%), Positives = 279/641 (43%), Gaps = 95/641 (14%)

Query: 320  INARKFEEMNAELEENKELAQNRLCELEKLRQDFEE--VTTQNEKLKVELRSAVEQVVKE 377
            + + + E+  A ++E  E  +  L + E  R++ EE  VT   EK  ++L+   E     
Sbjct: 844  LKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALA 903

Query: 378  TPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTE 437
              E RC Q     L    +QL+A + E                E  E DE  ++ +L  +
Sbjct: 904  DAEERCDQ-----LIKTKIQLEAKIKEV--------------TERAE-DEEEINAELTAK 943

Query: 438  VIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRY 497
              +LED  ++++K+ +    + E TLA       + +E     + ++N   ++ G     
Sbjct: 944  KRKLEDECSELKKDID----DLELTLAK------VEKEKHATENKVKNLTEEMAG----- 988

Query: 498  KRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDA 557
               L E  + L K +     AL ++   T D      +L+ + + +++ + A    ++  
Sbjct: 989  ---LDETIAKLTKEK----KALQEAHQQTLD------DLQMEEDKVNTLTKAKTKLEQQV 1035

Query: 558  NEIKSKRDEEER-----ERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEK 612
            ++++   ++E++     ER +R+ E + +  +E   + E +KQ+L E  K+++      +
Sbjct: 1036 DDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQ 1095

Query: 613  GKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRD--------KVQLM 664
            GK +D +    ++ K++K    + +E ++E++        A K++ D          +L 
Sbjct: 1096 GKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLE 1155

Query: 665  AAEKKSKAELEDLRQRLKDLE----DKEKKENKKMADEDALRK-----IRAVEEQIEYLQ 715
             A   + A++E  ++R  + +    D E+   +  A   ALRK     +  + EQI+ LQ
Sbjct: 1156 EAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQ 1215

Query: 716  KKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIH- 774
            +     ++E+  L  E++      E +             K  ANF+ M   ++      
Sbjct: 1216 RVKQKLEKEKSELKMEINDLASNMETV------------SKAKANFEKMCRTLEDQLSEI 1263

Query: 775  KLLKEEKEELADQVLTLKTQVDAQL-QVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMN 833
            K  +EE++ L +++   K ++  +  +  R+L+EK+ ++ S +  G++     TQ +E  
Sbjct: 1264 KTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMV-SQLSRGKQAF---TQQIEEL 1319

Query: 834  KRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKL 893
            KR+  E  +    L   L+ A+      +++  E    K +      +A  ++++ R K 
Sbjct: 1320 KRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKY 1379

Query: 894  ET-----TKKPDNVPKCDEILMEEIKDYKARLTCPCCNMRK 929
            ET     T++ +   K     +++ +++   +   C ++ K
Sbjct: 1380 ETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEK 1420



 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 151/691 (21%), Positives = 292/691 (42%), Gaps = 84/691 (12%)

Query: 240  QEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERV 299
            +++   M +EF K + ++   E++   LE  +  L  + + ++ + Q     LA+  ER 
Sbjct: 850  EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERC 909

Query: 300  NSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDFEEVTTQ 359
            +          + +    +T  A   EE+NAEL   K   ++   EL+K   D E    +
Sbjct: 910  DQLIKTKIQLEAKIK--EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 967

Query: 360  NEKLKVELRSAVEQVVKE-TPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQH 418
             EK K     A E  VK  T E   +    + L  E    K  L EA          HQ 
Sbjct: 968  VEKEK----HATENKVKNLTEEMAGLDETIAKLTKE----KKALQEA----------HQQ 1009

Query: 419  QVE--LIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREM 476
             ++   +E D+V+   K +T++ Q  D L    ++ + L ++ E+     E    + +E 
Sbjct: 1010 TLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQE- 1068

Query: 477  RHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSAL-LQSQSSTEDPKDEPAE 535
                S++   N +   + L  K K +E +    + ++    AL +Q Q   +       E
Sbjct: 1069 ----STMDTENDK---QQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIK-------E 1114

Query: 536  LKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKE------REREREREKEKE 589
            L+   E+L  +  A +AS+  A + +S    E  E   R +E       + E  +++E E
Sbjct: 1115 LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE 1174

Query: 590  REREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDM 649
             ++ ++ L+ES  + ++     + KH D   +  E I  L+   +K ++ + E+K+    
Sbjct: 1175 FQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKM---- 1230

Query: 650  YRSAPKEQRDKVQLMAAEKKSKAELE----DLRQRLKDLEDKEKKENKKMADEDALRKIR 705
                  E  D    M    K+KA  E     L  +L +++ KE +E +++ +E + +K R
Sbjct: 1231 ------EINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKE-EEQQRLINELSAQKAR 1283

Query: 706  AVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAF-EDMQEQNIRLMQQLREKDDANFKLM 764
               E  E+ ++       E++A++S++    QAF + ++E   +L ++ + K      L 
Sbjct: 1284 LHTESGEFSRQ-----LDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQ 1338

Query: 765  SERIKSNQIHKLLKEEKEELAD----------QVLTLKTQVDAQ-LQVVRKLEEKEHLLQ 813
            S R   + + +  +EE+E  A+          +V   +T+ +   +Q   +LEE +  L 
Sbjct: 1339 SARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1398

Query: 814  SNIGTGEKE---LGLRTQALEMNKRKAM-EAAQLADDLK---AQLELAQKKLHDFQDEIV 866
              +   E+    +  +  +LE  K++   E   L  D++   A      KK  +F   + 
Sbjct: 1399 QRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLA 1458

Query: 867  ENSVTKEKDMFNFKRAQEDISRLRRKLETTK 897
            E     E+     + +Q++   L  +L   K
Sbjct: 1459 EWKQKYEETQAELEASQKESRSLSTELFKVK 1489



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 74/302 (24%), Positives = 140/302 (46%), Gaps = 29/302 (9%)

Query: 633  LKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKEN 692
            L K+ E++KEM  + + +    KE+  K +  A  K+ + ++  L Q   DL+ + + E 
Sbjct: 843  LLKSAETEKEMANMKEEFEKT-KEELAKTE--AKRKELEEKMVTLMQEKNDLQLQVQAEA 899

Query: 693  KKMAD-EDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEM--------DVTGQAFEDMQ 743
              +AD E+   ++   + Q+E   K++    ++EE + +E+        D   +  +D+ 
Sbjct: 900  DALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDID 959

Query: 744  EQNIRLMQQLREK--DDANFKLMSERIK--SNQIHKLLKEEKEELADQVLTLKTQVDAQL 799
            +  + L +  +EK   +   K ++E +      I KL KE+K   A Q    +T  D Q+
Sbjct: 960  DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKK---ALQEAHQQTLDDLQM 1016

Query: 800  QVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLH 859
            +     E+K + L       E+++     +LE  K+  M+  +    L+  L+LAQ+   
Sbjct: 1017 E-----EDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTM 1071

Query: 860  DFQD---EIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDY 916
            D ++   ++ E    KE +M N +   ED   L  +L+  KK   +    E L EEI+  
Sbjct: 1072 DTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQ--KKIKELQARIEELEEEIEAE 1129

Query: 917  KA 918
            +A
Sbjct: 1130 RA 1131


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  125 bits (313), Expect = 3e-28
 Identities = 210/1004 (20%), Positives = 407/1004 (40%), Gaps = 164/1004 (16%)

Query: 55   NRKLAEMLDQRQAIEDELREHIEKLERRQ--------ATDDASLLIVNRYWSQFDE---- 102
            ++ + E L Q QA+ +E+  H EK+E  Q        A  D  L +V  Y +Q +     
Sbjct: 1241 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT-YKAQLEPVASP 1299

Query: 103  ---------NIRIILKRYDLEQGLGDL--LTERKALVVPE-----PEPDSDSNQERKDDR 146
                     +  +I +  DL     +L  LT +    + E      E +  + Q+R ++R
Sbjct: 1300 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1359

Query: 147  ERGEGQEPAFSFLATLASS----------SSEEMESQLQERVESSRRAVSQIVTVYDKLQ 196
            ER    E A      LA +           ++E++ ++QE V     A          +Q
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419

Query: 197  EKVELLSRKLNSGDNLIVEEA-VQELNSFLAQENMRLQELTDLLQEKHRTMSQ-EFSKLQ 254
            E+++ L +   +       +A   E +    +E +R+  L     E+ R  ++ E   L+
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479

Query: 255  SKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLY 314
            ++ E AE++    +   + L+  +    +R+++    LA  ++       +   A  +L 
Sbjct: 1480 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1539

Query: 315  GGTITINARKFEEMNAELEENKEL-------AQNRLCELEKLRQDFEEVTTQNEKLKVEL 367
               +     +     AE+E  +++        ++   EL+  R  F E T Q E+   E 
Sbjct: 1540 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1599

Query: 368  RSAVEQVVKETPEYRCMQ---------------SQFSVLYNESLQLKAHLDEARTLLHGT 412
              AV Q ++E  E R  Q                ++ +  NE+L+L+   +E        
Sbjct: 1600 HVAVAQ-LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658

Query: 413  RGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPI 472
            +   + Q E  ER+     K     V Q E    ++ K+ ++     +Q LAA ++   +
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1718

Query: 473  NREM---RHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDP 529
              E          L+    +L+ E     +K +E +++L K R      LL S++  E+ 
Sbjct: 1719 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-EVLLASKARAEEE 1777

Query: 530  KDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERERER------- 582
                +E     + L +++   +   E+A  +++  +E +R+R+  E++  R+R       
Sbjct: 1778 SRSTSE--KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1835

Query: 583  ----------------------EREKEKERERE-----------------------KQKL 597
                                  E+E E ER R                        +++L
Sbjct: 1836 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895

Query: 598  KESEKERDSAKDKEKGKHDD---GRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAP 654
             +  K  DS  +++KG  +D    R++  E I  LK   +KA   + E++L L   RS  
Sbjct: 1896 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1955

Query: 655  KE---QRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQI 711
            ++    +++ +L AA ++  A  E+ R+R    E +E+ +    A+E+A R+ +A  E++
Sbjct: 1956 EDTLRSKEQAELEAARQRQLAAEEERRRR----EAEERVQKSLAAEEEAARQRKAALEEV 2011

Query: 712  EYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSN 771
            E L+ K+  A++  E    E     Q  ++  ++ +    Q  EK  A     + + K  
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL----QAEEKAHA----FAVQQKEQ 2063

Query: 772  QIHKLLKEEKEEL-------------ADQVLTLKTQVDAQ-LQVVRKLEEKEHLLQSNIG 817
            ++ + L++E+  L             A++    + Q + +  Q  R++EE E L QS   
Sbjct: 2064 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123

Query: 818  TGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMF 877
              +     +  A ++ K    EAA+ A     Q  L QK+  D   E+ ++    E+ + 
Sbjct: 2124 QAQARAQAQAAAEKLRKEAEQEAARRAQ--AEQAALRQKQAAD--AEMEKHKKFAEQTLR 2179

Query: 878  NFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDYKARLT 921
               + +++++ LR +LE T    N      +L EE++  KA  T
Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKN------LLDEELQRLKAEAT 2217



 Score =  102 bits (255), Expect = 1e-21
 Identities = 200/973 (20%), Positives = 390/973 (40%), Gaps = 157/973 (16%)

Query: 36   KLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNR 95
            K   + + EEL ++  + + R        RQA  +  R+    LE  Q + +A L     
Sbjct: 1531 KQRALQALEELRLQAEEAERRL-------RQAEVERARQVQVALETAQRSAEAELQSKRA 1583

Query: 96   YWSQFDENIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPA 155
             +++         K   LE+ L +   E  A+     E +  + Q+ + +R R E +   
Sbjct: 1584 SFAE---------KTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAERE- 1630

Query: 156  FSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVE 215
               L      ++E +  +LQ    + +++++Q     +K +E+ E  +R+    +    E
Sbjct: 1631 ---LERWQLKANEALRLRLQAEEVAQQKSLAQAEA--EKQKEEAEREARRRGKAE----E 1681

Query: 216  EAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQ 275
            +AV++      QE  + ++L +   ++     QE  +L+++ E  E +  +LE  +  LQ
Sbjct: 1682 QAVRQ-RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1740

Query: 276  WDIDKIRKREQRLNRHLA------EVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMN 329
             +     ++ Q L   LA      EVL    ++  +   + S      +   A +F E+ 
Sbjct: 1741 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1800

Query: 330  AELEENKELA-----QNRLCELEKLRQDFEEVTTQNEKL---------KVELRSAVEQVV 375
             E    + LA     Q +L E +  RQ  E      EKL         K E   A+++  
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1860

Query: 376  KETPEYRCMQS----QFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLH 431
             E    R +      Q   L  ++ Q KA ++E    L     +   + + +  D +   
Sbjct: 1861 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920

Query: 432  KKLRTEVIQLEDTL-------AQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQ 484
            +++  E++ L+ +        A++  E   +R   E TL + EQA       R L +  +
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1980

Query: 485  NHNHQLKG---------------------EVLRYKRKLREAQSDLNKTRLRSGSALLQSQ 523
                + +                      EV R K K+ EA+    +    S   L  +Q
Sbjct: 1981 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040

Query: 524  SSTEDPKDEPAELKPDS---------------------EDLSSQSSASKASQEDANEIKS 562
             + +  K   AE K  +                     + L  ++ A++ + E+A E + 
Sbjct: 2041 EAAQ--KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2098

Query: 563  KRDEEERERERREKEREREREREKEKEREREK-----QKL-KESEKERDSAKDKEKGKHD 616
            + + E  +  R+ +E ER ++  +E+ + R +     +KL KE+E+E       E+    
Sbjct: 2099 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2158

Query: 617  DGRKKEAEIIKQLKIE----LKKAQESQKEMKLLLDMYRSAPKE-------QRDKVQLMA 665
              +  +AE+ K  K       +KAQ  Q+   L L +  +  ++       QR K +   
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218

Query: 666  AEKKSKAELEDL------RQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQK--- 716
            A ++     E+L       + L  L+ + + EN+ +   D     R ++E+ E +++   
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2278

Query: 717  ---KLAMAKQEEEAL--LSEMDVTGQ--AFEDMQEQNIRLMQQ-LREKDDANFKLMSERI 768
               +L++A QE   L  L+E D+  Q    E M ++ ++ +Q+  R K +A      + +
Sbjct: 2279 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2338

Query: 769  KSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQ 828
               Q  + L+E+KE++A Q+         + Q  ++  E E   Q  +    + L LR  
Sbjct: 2339 AQEQARR-LQEDKEQMAQQLA-------EETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390

Query: 829  ALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVEN-------SVTKEKDMFNFKR 881
             +   + +A E AQ     + Q E   +KLH  +    E         + +++   + +R
Sbjct: 2391 EMSRAQARAEEDAQ---RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2447

Query: 882  AQEDISRLRRKLE 894
             +E I+ L R+ E
Sbjct: 2448 LREAIAELEREKE 2460



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 166/835 (19%), Positives = 338/835 (40%), Gaps = 150/835 (17%)

Query: 124  RKALVVPEPEPDSDSNQER-KDDRERGEGQEPAFSFLATLASSSSEEMESQLQER----- 177
            ++A  VP   P+ ++ +   K  R + E Q+P F  L       ++E+  +LQ+R     
Sbjct: 1113 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD-ELRGAQEVGERLQQRHGERD 1171

Query: 178  --VESSRRAVSQIVTVYDKLQEKVELLSRKLNS-GDNL-IVEEAVQELNSFLAQENMRLQ 233
              VE  R  V+Q++  +  +  + ++  R+L   G  L    E+   L ++L     R +
Sbjct: 1172 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1231

Query: 234  ELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLA 293
            ++  +     + + ++  + Q+ +E  E     +E      +  I+ I+  E +L  + A
Sbjct: 1232 QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1291

Query: 294  EVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDF 353
            + LE V S   K      S                           ++ + E   LR  +
Sbjct: 1292 Q-LEPVASPAKKPKVQSGS---------------------------ESVIQEYVDLRTHY 1323

Query: 354  EEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTR 413
             E+TT   +    ++   E + +   E R  + Q +       +++A L++ R L     
Sbjct: 1324 SELTTLTSQY---IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-- 1378

Query: 414  GTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPIN 473
              H       ER+   L ++++ EV++ E+     +++   ++ E +Q   ++E    I 
Sbjct: 1379 --HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE--AEIQ 1434

Query: 474  REMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEP 533
             + R   ++ ++         LR + ++R  +  L  T  + G A               
Sbjct: 1435 AKARQAEAAERSR--------LRIEEEIRVVRLQLEATERQRGGA--------------- 1471

Query: 534  AELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERERERERE-------- 585
                        +  A +A  E+A E + ++ +EE ER RR+ + E +R+R+        
Sbjct: 1472 ----------EGELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1520

Query: 586  --KEKEREREKQK-LKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQES--- 639
               E E  REKQ+ L+  E+ R  A++ E+      R+ E E  +Q+++ L+ AQ S   
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEAERRL----RQAEVERARQVQVALETAQRSAEA 1576

Query: 640  --------------------QKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAEL----- 674
                                Q+E   +  +   A +  + + +   A ++++ EL     
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1636

Query: 675  ---EDLRQRL--------KDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQ 723
               E LR RL        K L   E ++ K+ A+ +A R+ +A E+ +   Q++LA  + 
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR--QRELAEQEL 1694

Query: 724  EEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEE 783
            E++  L+E   T Q     +++ IRL  +  + +     L  E  +  +      ++++E
Sbjct: 1695 EKQRQLAE--GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752

Query: 784  LADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQL 843
            L  ++  ++ +++  L    + EE+         T EK      Q LE    +  E A+ 
Sbjct: 1753 LEAELAKVRAEMEVLLASKARAEEESR------STSEKS----KQRLEAEAGRFRELAEE 1802

Query: 844  ADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKK 898
            A  L+A  E A+++    +++        E+ +     A  + +RL+ + E   K
Sbjct: 1803 AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1857



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 183/903 (20%), Positives = 380/903 (42%), Gaps = 127/903 (14%)

Query: 20   EKKAAVEDSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKL 79
            EK AA    G     ++LG + S  E    TL++K +   E   QRQ   +E R   E  
Sbjct: 1935 EKAAA----GKAELELELGRIRSNAE---DTLRSKEQAELEAARQRQLAAEEERRRREAE 1987

Query: 80   ERRQAT----------DDASLLIVNRYWSQFDENIRI-------ILKRYDLEQGLGD--L 120
            ER Q +            A+L  V R  ++ +E  R+         ++  L Q      L
Sbjct: 1988 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2047

Query: 121  LTERKA--LVVPEPEPDSDSNQERKD---DRERGEGQEPAFSFLATLASSSSEEMESQLQ 175
              E KA    V + E +     +++    D+ RGE +       A  A+  +EE   Q +
Sbjct: 2048 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA------ARRAAEEAEEARVQAE 2101

Query: 176  ERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQEL--NSFLAQENMRLQ 233
                 SRR V +   +    +E+ +  ++   + + L  +EA QE    +   Q  +R +
Sbjct: 2102 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR-KEAEQEAARRAQAEQAALRQK 2160

Query: 234  ELTDLLQEKHRTMS-----------QEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIR 282
            +  D   EKH+  +           QE + L+ ++E  + + ++L+  +  L+ +  +  
Sbjct: 2161 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2220

Query: 283  KREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITI----NARKFEEMNAELEENKEL 338
            ++  ++   L  V  RV  +      A        + +    N ++F  +  E E+ K++
Sbjct: 2221 RQRSQVEEELFSV--RVQMEELSKLKARIEAENRALILRDKDNTQRF--LQEEAEKMKQV 2276

Query: 339  AQN--RLC----ELEKLRQDFEEVTTQN----EKLKVELRSAVEQVVKETPEYRCMQSQF 388
            A+   RL     E  +LRQ  EE   Q     EK+  E   AV++  +   E   +Q Q 
Sbjct: 2277 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336

Query: 389  SVLYNESLQLKAHLDE-ARTLLHGTRGTHQHQVELIERDEVSLH---KKLRTEVIQLEDT 444
             +   ++ +L+   ++ A+ L   T+G  Q  +E   + ++ +    ++L+  V ++   
Sbjct: 2337 ELAQEQARRLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2395

Query: 445  LAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREA 504
             A+  ++ +  R + E+      +     +E   L+ +L+    Q   +  R +  + E 
Sbjct: 2396 QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2455

Query: 505  QSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKAS---------QE 555
            + +  K +L+  + LLQ +S  E    +  +L  +++ L     + K S         QE
Sbjct: 2456 ERE--KEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2512

Query: 556  DANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKH 615
             A   +  +DE  + ++ RE+++ ++++ E  +ER+R    ++E+ + +  A++  + K 
Sbjct: 2513 KAKLEQLFQDEVAKAQQLREEQQRQQQQME--QERQRLVASMEEARRRQHEAEEGVRRKQ 2570

Query: 616  DDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQ-----------------R 658
            ++ ++ E +  +Q ++  ++ Q  +++++LL + +R+A                     R
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR 2630

Query: 659  DKVQLMAAEKKSKAELEDLR-----QRLKDLEDKEKKENKKMAD-EDALRKIRAVEEQIE 712
            D +   AAE + +   + LR     QRL++      +E +++A     + ++   E+   
Sbjct: 2631 DALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRH 2690

Query: 713  YLQKKLAMAKQEEEALLSEMDV------------TGQAFEDMQEQNIRLMQQLREKDDAN 760
            YLQ + ++A    +A   ++ V            T     + Q  +  L+  +R +    
Sbjct: 2691 YLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTV 2750

Query: 761  FKLMSERIKSNQI-HKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEH---LLQSNI 816
             + + E +   ++ HKLL  E+     +      Q+     + + L  +EH   LL++ I
Sbjct: 2751 NEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQI 2810

Query: 817  GTG 819
             TG
Sbjct: 2811 ATG 2813


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  125 bits (313), Expect = 3e-28
 Identities = 210/1004 (20%), Positives = 407/1004 (40%), Gaps = 164/1004 (16%)

Query: 55   NRKLAEMLDQRQAIEDELREHIEKLERRQ--------ATDDASLLIVNRYWSQFDE---- 102
            ++ + E L Q QA+ +E+  H EK+E  Q        A  D  L +V  Y +Q +     
Sbjct: 1245 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT-YKAQLEPVASP 1303

Query: 103  ---------NIRIILKRYDLEQGLGDL--LTERKALVVPE-----PEPDSDSNQERKDDR 146
                     +  +I +  DL     +L  LT +    + E      E +  + Q+R ++R
Sbjct: 1304 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1363

Query: 147  ERGEGQEPAFSFLATLASS----------SSEEMESQLQERVESSRRAVSQIVTVYDKLQ 196
            ER    E A      LA +           ++E++ ++QE V     A          +Q
Sbjct: 1364 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1423

Query: 197  EKVELLSRKLNSGDNLIVEEA-VQELNSFLAQENMRLQELTDLLQEKHRTMSQ-EFSKLQ 254
            E+++ L +   +       +A   E +    +E +R+  L     E+ R  ++ E   L+
Sbjct: 1424 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1483

Query: 255  SKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLY 314
            ++ E AE++    +   + L+  +    +R+++    LA  ++       +   A  +L 
Sbjct: 1484 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1543

Query: 315  GGTITINARKFEEMNAELEENKEL-------AQNRLCELEKLRQDFEEVTTQNEKLKVEL 367
               +     +     AE+E  +++        ++   EL+  R  F E T Q E+   E 
Sbjct: 1544 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1603

Query: 368  RSAVEQVVKETPEYRCMQ---------------SQFSVLYNESLQLKAHLDEARTLLHGT 412
              AV Q ++E  E R  Q                ++ +  NE+L+L+   +E        
Sbjct: 1604 HVAVAQ-LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1662

Query: 413  RGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPI 472
            +   + Q E  ER+     K     V Q E    ++ K+ ++     +Q LAA ++   +
Sbjct: 1663 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1722

Query: 473  NREM---RHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDP 529
              E          L+    +L+ E     +K +E +++L K R      LL S++  E+ 
Sbjct: 1723 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-EVLLASKARAEEE 1781

Query: 530  KDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERERER------- 582
                +E     + L +++   +   E+A  +++  +E +R+R+  E++  R+R       
Sbjct: 1782 SRSTSE--KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1839

Query: 583  ----------------------EREKEKERERE-----------------------KQKL 597
                                  E+E E ER R                        +++L
Sbjct: 1840 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1899

Query: 598  KESEKERDSAKDKEKGKHDD---GRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAP 654
             +  K  DS  +++KG  +D    R++  E I  LK   +KA   + E++L L   RS  
Sbjct: 1900 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1959

Query: 655  KE---QRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQI 711
            ++    +++ +L AA ++  A  E+ R+R    E +E+ +    A+E+A R+ +A  E++
Sbjct: 1960 EDTLRSKEQAELEAARQRQLAAEEERRRR----EAEERVQKSLAAEEEAARQRKAALEEV 2015

Query: 712  EYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSN 771
            E L+ K+  A++  E    E     Q  ++  ++ +    Q  EK  A     + + K  
Sbjct: 2016 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL----QAEEKAHA----FAVQQKEQ 2067

Query: 772  QIHKLLKEEKEEL-------------ADQVLTLKTQVDAQ-LQVVRKLEEKEHLLQSNIG 817
            ++ + L++E+  L             A++    + Q + +  Q  R++EE E L QS   
Sbjct: 2068 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2127

Query: 818  TGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMF 877
              +     +  A ++ K    EAA+ A     Q  L QK+  D   E+ ++    E+ + 
Sbjct: 2128 QAQARAQAQAAAEKLRKEAEQEAARRAQ--AEQAALRQKQAAD--AEMEKHKKFAEQTLR 2183

Query: 878  NFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDYKARLT 921
               + +++++ LR +LE T    N      +L EE++  KA  T
Sbjct: 2184 QKAQVEQELTTLRLQLEETDHQKN------LLDEELQRLKAEAT 2221



 Score =  102 bits (255), Expect = 1e-21
 Identities = 200/973 (20%), Positives = 390/973 (40%), Gaps = 157/973 (16%)

Query: 36   KLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNR 95
            K   + + EEL ++  + + R        RQA  +  R+    LE  Q + +A L     
Sbjct: 1535 KQRALQALEELRLQAEEAERRL-------RQAEVERARQVQVALETAQRSAEAELQSKRA 1587

Query: 96   YWSQFDENIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPA 155
             +++         K   LE+ L +   E  A+     E +  + Q+ + +R R E +   
Sbjct: 1588 SFAE---------KTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAERE- 1634

Query: 156  FSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVE 215
               L      ++E +  +LQ    + +++++Q     +K +E+ E  +R+    +    E
Sbjct: 1635 ---LERWQLKANEALRLRLQAEEVAQQKSLAQAEA--EKQKEEAEREARRRGKAE----E 1685

Query: 216  EAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQ 275
            +AV++      QE  + ++L +   ++     QE  +L+++ E  E +  +LE  +  LQ
Sbjct: 1686 QAVRQ-RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1744

Query: 276  WDIDKIRKREQRLNRHLA------EVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMN 329
             +     ++ Q L   LA      EVL    ++  +   + S      +   A +F E+ 
Sbjct: 1745 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1804

Query: 330  AELEENKELA-----QNRLCELEKLRQDFEEVTTQNEKL---------KVELRSAVEQVV 375
             E    + LA     Q +L E +  RQ  E      EKL         K E   A+++  
Sbjct: 1805 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1864

Query: 376  KETPEYRCMQS----QFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLH 431
             E    R +      Q   L  ++ Q KA ++E    L     +   + + +  D +   
Sbjct: 1865 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1924

Query: 432  KKLRTEVIQLEDTL-------AQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQ 484
            +++  E++ L+ +        A++  E   +R   E TL + EQA       R L +  +
Sbjct: 1925 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1984

Query: 485  NHNHQLKG---------------------EVLRYKRKLREAQSDLNKTRLRSGSALLQSQ 523
                + +                      EV R K K+ EA+    +    S   L  +Q
Sbjct: 1985 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2044

Query: 524  SSTEDPKDEPAELKPDS---------------------EDLSSQSSASKASQEDANEIKS 562
             + +  K   AE K  +                     + L  ++ A++ + E+A E + 
Sbjct: 2045 EAAQ--KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2102

Query: 563  KRDEEERERERREKEREREREREKEKEREREK-----QKL-KESEKERDSAKDKEKGKHD 616
            + + E  +  R+ +E ER ++  +E+ + R +     +KL KE+E+E       E+    
Sbjct: 2103 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2162

Query: 617  DGRKKEAEIIKQLKIE----LKKAQESQKEMKLLLDMYRSAPKE-------QRDKVQLMA 665
              +  +AE+ K  K       +KAQ  Q+   L L +  +  ++       QR K +   
Sbjct: 2163 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2222

Query: 666  AEKKSKAELEDL------RQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQK--- 716
            A ++     E+L       + L  L+ + + EN+ +   D     R ++E+ E +++   
Sbjct: 2223 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2282

Query: 717  ---KLAMAKQEEEAL--LSEMDVTGQ--AFEDMQEQNIRLMQQ-LREKDDANFKLMSERI 768
               +L++A QE   L  L+E D+  Q    E M ++ ++ +Q+  R K +A      + +
Sbjct: 2283 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2342

Query: 769  KSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQ 828
               Q  + L+E+KE++A Q+         + Q  ++  E E   Q  +    + L LR  
Sbjct: 2343 AQEQARR-LQEDKEQMAQQLA-------EETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2394

Query: 829  ALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVEN-------SVTKEKDMFNFKR 881
             +   + +A E AQ     + Q E   +KLH  +    E         + +++   + +R
Sbjct: 2395 EMSRAQARAEEDAQ---RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2451

Query: 882  AQEDISRLRRKLE 894
             +E I+ L R+ E
Sbjct: 2452 LREAIAELEREKE 2464



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 166/835 (19%), Positives = 338/835 (40%), Gaps = 150/835 (17%)

Query: 124  RKALVVPEPEPDSDSNQER-KDDRERGEGQEPAFSFLATLASSSSEEMESQLQER----- 177
            ++A  VP   P+ ++ +   K  R + E Q+P F  L       ++E+  +LQ+R     
Sbjct: 1117 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD-ELRGAQEVGERLQQRHGERD 1175

Query: 178  --VESSRRAVSQIVTVYDKLQEKVELLSRKLNS-GDNL-IVEEAVQELNSFLAQENMRLQ 233
              VE  R  V+Q++  +  +  + ++  R+L   G  L    E+   L ++L     R +
Sbjct: 1176 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1235

Query: 234  ELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLA 293
            ++  +     + + ++  + Q+ +E  E     +E      +  I+ I+  E +L  + A
Sbjct: 1236 QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1295

Query: 294  EVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDF 353
            + LE V S   K      S                           ++ + E   LR  +
Sbjct: 1296 Q-LEPVASPAKKPKVQSGS---------------------------ESVIQEYVDLRTHY 1327

Query: 354  EEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTR 413
             E+TT   +    ++   E + +   E R  + Q +       +++A L++ R L     
Sbjct: 1328 SELTTLTSQY---IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-- 1382

Query: 414  GTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPIN 473
              H       ER+   L ++++ EV++ E+     +++   ++ E +Q   ++E    I 
Sbjct: 1383 --HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE--AEIQ 1438

Query: 474  REMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEP 533
             + R   ++ ++         LR + ++R  +  L  T  + G A               
Sbjct: 1439 AKARQAEAAERSR--------LRIEEEIRVVRLQLEATERQRGGA--------------- 1475

Query: 534  AELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERERERERE-------- 585
                        +  A +A  E+A E + ++ +EE ER RR+ + E +R+R+        
Sbjct: 1476 ----------EGELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1524

Query: 586  --KEKEREREKQK-LKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQES--- 639
               E E  REKQ+ L+  E+ R  A++ E+      R+ E E  +Q+++ L+ AQ S   
Sbjct: 1525 VKAEAEAAREKQRALQALEELRLQAEEAERRL----RQAEVERARQVQVALETAQRSAEA 1580

Query: 640  --------------------QKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAEL----- 674
                                Q+E   +  +   A +  + + +   A ++++ EL     
Sbjct: 1581 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1640

Query: 675  ---EDLRQRL--------KDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQ 723
               E LR RL        K L   E ++ K+ A+ +A R+ +A E+ +   Q++LA  + 
Sbjct: 1641 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR--QRELAEQEL 1698

Query: 724  EEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEE 783
            E++  L+E   T Q     +++ IRL  +  + +     L  E  +  +      ++++E
Sbjct: 1699 EKQRQLAE--GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1756

Query: 784  LADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQL 843
            L  ++  ++ +++  L    + EE+         T EK      Q LE    +  E A+ 
Sbjct: 1757 LEAELAKVRAEMEVLLASKARAEEESR------STSEKS----KQRLEAEAGRFRELAEE 1806

Query: 844  ADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKK 898
            A  L+A  E A+++    +++        E+ +     A  + +RL+ + E   K
Sbjct: 1807 AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1861



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 183/903 (20%), Positives = 380/903 (42%), Gaps = 127/903 (14%)

Query: 20   EKKAAVEDSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKL 79
            EK AA    G     ++LG + S  E    TL++K +   E   QRQ   +E R   E  
Sbjct: 1939 EKAAA----GKAELELELGRIRSNAE---DTLRSKEQAELEAARQRQLAAEEERRRREAE 1991

Query: 80   ERRQAT----------DDASLLIVNRYWSQFDENIRI-------ILKRYDLEQGLGD--L 120
            ER Q +            A+L  V R  ++ +E  R+         ++  L Q      L
Sbjct: 1992 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2051

Query: 121  LTERKA--LVVPEPEPDSDSNQERKD---DRERGEGQEPAFSFLATLASSSSEEMESQLQ 175
              E KA    V + E +     +++    D+ RGE +       A  A+  +EE   Q +
Sbjct: 2052 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA------ARRAAEEAEEARVQAE 2105

Query: 176  ERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQEL--NSFLAQENMRLQ 233
                 SRR V +   +    +E+ +  ++   + + L  +EA QE    +   Q  +R +
Sbjct: 2106 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR-KEAEQEAARRAQAEQAALRQK 2164

Query: 234  ELTDLLQEKHRTMS-----------QEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIR 282
            +  D   EKH+  +           QE + L+ ++E  + + ++L+  +  L+ +  +  
Sbjct: 2165 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2224

Query: 283  KREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITI----NARKFEEMNAELEENKEL 338
            ++  ++   L  V  RV  +      A        + +    N ++F  +  E E+ K++
Sbjct: 2225 RQRSQVEEELFSV--RVQMEELSKLKARIEAENRALILRDKDNTQRF--LQEEAEKMKQV 2280

Query: 339  AQN--RLC----ELEKLRQDFEEVTTQN----EKLKVELRSAVEQVVKETPEYRCMQSQF 388
            A+   RL     E  +LRQ  EE   Q     EK+  E   AV++  +   E   +Q Q 
Sbjct: 2281 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2340

Query: 389  SVLYNESLQLKAHLDE-ARTLLHGTRGTHQHQVELIERDEVSLH---KKLRTEVIQLEDT 444
             +   ++ +L+   ++ A+ L   T+G  Q  +E   + ++ +    ++L+  V ++   
Sbjct: 2341 ELAQEQARRLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2399

Query: 445  LAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREA 504
             A+  ++ +  R + E+      +     +E   L+ +L+    Q   +  R +  + E 
Sbjct: 2400 QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2459

Query: 505  QSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKAS---------QE 555
            + +  K +L+  + LLQ +S  E    +  +L  +++ L     + K S         QE
Sbjct: 2460 ERE--KEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2516

Query: 556  DANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKH 615
             A   +  +DE  + ++ RE+++ ++++ E  +ER+R    ++E+ + +  A++  + K 
Sbjct: 2517 KAKLEQLFQDEVAKAQQLREEQQRQQQQME--QERQRLVASMEEARRRQHEAEEGVRRKQ 2574

Query: 616  DDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQ-----------------R 658
            ++ ++ E +  +Q ++  ++ Q  +++++LL + +R+A                     R
Sbjct: 2575 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR 2634

Query: 659  DKVQLMAAEKKSKAELEDLR-----QRLKDLEDKEKKENKKMAD-EDALRKIRAVEEQIE 712
            D +   AAE + +   + LR     QRL++      +E +++A     + ++   E+   
Sbjct: 2635 DALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRH 2694

Query: 713  YLQKKLAMAKQEEEALLSEMDV------------TGQAFEDMQEQNIRLMQQLREKDDAN 760
            YLQ + ++A    +A   ++ V            T     + Q  +  L+  +R +    
Sbjct: 2695 YLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTV 2754

Query: 761  FKLMSERIKSNQI-HKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEH---LLQSNI 816
             + + E +   ++ HKLL  E+     +      Q+     + + L  +EH   LL++ I
Sbjct: 2755 NEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQI 2814

Query: 817  GTG 819
             TG
Sbjct: 2815 ATG 2817


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  125 bits (313), Expect = 3e-28
 Identities = 210/1004 (20%), Positives = 407/1004 (40%), Gaps = 164/1004 (16%)

Query: 55   NRKLAEMLDQRQAIEDELREHIEKLERRQ--------ATDDASLLIVNRYWSQFDE---- 102
            ++ + E L Q QA+ +E+  H EK+E  Q        A  D  L +V  Y +Q +     
Sbjct: 1241 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT-YKAQLEPVASP 1299

Query: 103  ---------NIRIILKRYDLEQGLGDL--LTERKALVVPE-----PEPDSDSNQERKDDR 146
                     +  +I +  DL     +L  LT +    + E      E +  + Q+R ++R
Sbjct: 1300 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1359

Query: 147  ERGEGQEPAFSFLATLASS----------SSEEMESQLQERVESSRRAVSQIVTVYDKLQ 196
            ER    E A      LA +           ++E++ ++QE V     A          +Q
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419

Query: 197  EKVELLSRKLNSGDNLIVEEA-VQELNSFLAQENMRLQELTDLLQEKHRTMSQ-EFSKLQ 254
            E+++ L +   +       +A   E +    +E +R+  L     E+ R  ++ E   L+
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479

Query: 255  SKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLY 314
            ++ E AE++    +   + L+  +    +R+++    LA  ++       +   A  +L 
Sbjct: 1480 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1539

Query: 315  GGTITINARKFEEMNAELEENKEL-------AQNRLCELEKLRQDFEEVTTQNEKLKVEL 367
               +     +     AE+E  +++        ++   EL+  R  F E T Q E+   E 
Sbjct: 1540 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1599

Query: 368  RSAVEQVVKETPEYRCMQ---------------SQFSVLYNESLQLKAHLDEARTLLHGT 412
              AV Q ++E  E R  Q                ++ +  NE+L+L+   +E        
Sbjct: 1600 HVAVAQ-LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658

Query: 413  RGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPI 472
            +   + Q E  ER+     K     V Q E    ++ K+ ++     +Q LAA ++   +
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1718

Query: 473  NREM---RHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDP 529
              E          L+    +L+ E     +K +E +++L K R      LL S++  E+ 
Sbjct: 1719 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-EVLLASKARAEEE 1777

Query: 530  KDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERERER------- 582
                +E     + L +++   +   E+A  +++  +E +R+R+  E++  R+R       
Sbjct: 1778 SRSTSE--KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1835

Query: 583  ----------------------EREKEKERERE-----------------------KQKL 597
                                  E+E E ER R                        +++L
Sbjct: 1836 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895

Query: 598  KESEKERDSAKDKEKGKHDD---GRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAP 654
             +  K  DS  +++KG  +D    R++  E I  LK   +KA   + E++L L   RS  
Sbjct: 1896 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1955

Query: 655  KE---QRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQI 711
            ++    +++ +L AA ++  A  E+ R+R    E +E+ +    A+E+A R+ +A  E++
Sbjct: 1956 EDTLRSKEQAELEAARQRQLAAEEERRRR----EAEERVQKSLAAEEEAARQRKAALEEV 2011

Query: 712  EYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSN 771
            E L+ K+  A++  E    E     Q  ++  ++ +    Q  EK  A     + + K  
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL----QAEEKAHA----FAVQQKEQ 2063

Query: 772  QIHKLLKEEKEEL-------------ADQVLTLKTQVDAQ-LQVVRKLEEKEHLLQSNIG 817
            ++ + L++E+  L             A++    + Q + +  Q  R++EE E L QS   
Sbjct: 2064 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123

Query: 818  TGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMF 877
              +     +  A ++ K    EAA+ A     Q  L QK+  D   E+ ++    E+ + 
Sbjct: 2124 QAQARAQAQAAAEKLRKEAEQEAARRAQ--AEQAALRQKQAAD--AEMEKHKKFAEQTLR 2179

Query: 878  NFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDYKARLT 921
               + +++++ LR +LE T    N      +L EE++  KA  T
Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKN------LLDEELQRLKAEAT 2217



 Score =  102 bits (255), Expect = 1e-21
 Identities = 200/973 (20%), Positives = 390/973 (40%), Gaps = 157/973 (16%)

Query: 36   KLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNR 95
            K   + + EEL ++  + + R        RQA  +  R+    LE  Q + +A L     
Sbjct: 1531 KQRALQALEELRLQAEEAERRL-------RQAEVERARQVQVALETAQRSAEAELQSKRA 1583

Query: 96   YWSQFDENIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPA 155
             +++         K   LE+ L +   E  A+     E +  + Q+ + +R R E +   
Sbjct: 1584 SFAE---------KTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAERE- 1630

Query: 156  FSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVE 215
               L      ++E +  +LQ    + +++++Q     +K +E+ E  +R+    +    E
Sbjct: 1631 ---LERWQLKANEALRLRLQAEEVAQQKSLAQAEA--EKQKEEAEREARRRGKAE----E 1681

Query: 216  EAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQ 275
            +AV++      QE  + ++L +   ++     QE  +L+++ E  E +  +LE  +  LQ
Sbjct: 1682 QAVRQ-RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1740

Query: 276  WDIDKIRKREQRLNRHLA------EVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMN 329
             +     ++ Q L   LA      EVL    ++  +   + S      +   A +F E+ 
Sbjct: 1741 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1800

Query: 330  AELEENKELA-----QNRLCELEKLRQDFEEVTTQNEKL---------KVELRSAVEQVV 375
             E    + LA     Q +L E +  RQ  E      EKL         K E   A+++  
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1860

Query: 376  KETPEYRCMQS----QFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLH 431
             E    R +      Q   L  ++ Q KA ++E    L     +   + + +  D +   
Sbjct: 1861 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920

Query: 432  KKLRTEVIQLEDTL-------AQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQ 484
            +++  E++ L+ +        A++  E   +R   E TL + EQA       R L +  +
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1980

Query: 485  NHNHQLKG---------------------EVLRYKRKLREAQSDLNKTRLRSGSALLQSQ 523
                + +                      EV R K K+ EA+    +    S   L  +Q
Sbjct: 1981 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040

Query: 524  SSTEDPKDEPAELKPDS---------------------EDLSSQSSASKASQEDANEIKS 562
             + +  K   AE K  +                     + L  ++ A++ + E+A E + 
Sbjct: 2041 EAAQ--KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2098

Query: 563  KRDEEERERERREKEREREREREKEKEREREK-----QKL-KESEKERDSAKDKEKGKHD 616
            + + E  +  R+ +E ER ++  +E+ + R +     +KL KE+E+E       E+    
Sbjct: 2099 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2158

Query: 617  DGRKKEAEIIKQLKIE----LKKAQESQKEMKLLLDMYRSAPKE-------QRDKVQLMA 665
              +  +AE+ K  K       +KAQ  Q+   L L +  +  ++       QR K +   
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218

Query: 666  AEKKSKAELEDL------RQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQK--- 716
            A ++     E+L       + L  L+ + + EN+ +   D     R ++E+ E +++   
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2278

Query: 717  ---KLAMAKQEEEAL--LSEMDVTGQ--AFEDMQEQNIRLMQQ-LREKDDANFKLMSERI 768
               +L++A QE   L  L+E D+  Q    E M ++ ++ +Q+  R K +A      + +
Sbjct: 2279 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2338

Query: 769  KSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQ 828
               Q  + L+E+KE++A Q+         + Q  ++  E E   Q  +    + L LR  
Sbjct: 2339 AQEQARR-LQEDKEQMAQQLA-------EETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390

Query: 829  ALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVEN-------SVTKEKDMFNFKR 881
             +   + +A E AQ     + Q E   +KLH  +    E         + +++   + +R
Sbjct: 2391 EMSRAQARAEEDAQ---RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2447

Query: 882  AQEDISRLRRKLE 894
             +E I+ L R+ E
Sbjct: 2448 LREAIAELEREKE 2460



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 166/835 (19%), Positives = 338/835 (40%), Gaps = 150/835 (17%)

Query: 124  RKALVVPEPEPDSDSNQER-KDDRERGEGQEPAFSFLATLASSSSEEMESQLQER----- 177
            ++A  VP   P+ ++ +   K  R + E Q+P F  L       ++E+  +LQ+R     
Sbjct: 1113 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD-ELRGAQEVGERLQQRHGERD 1171

Query: 178  --VESSRRAVSQIVTVYDKLQEKVELLSRKLNS-GDNL-IVEEAVQELNSFLAQENMRLQ 233
              VE  R  V+Q++  +  +  + ++  R+L   G  L    E+   L ++L     R +
Sbjct: 1172 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1231

Query: 234  ELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLA 293
            ++  +     + + ++  + Q+ +E  E     +E      +  I+ I+  E +L  + A
Sbjct: 1232 QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1291

Query: 294  EVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDF 353
            + LE V S   K      S                           ++ + E   LR  +
Sbjct: 1292 Q-LEPVASPAKKPKVQSGS---------------------------ESVIQEYVDLRTHY 1323

Query: 354  EEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTR 413
             E+TT   +    ++   E + +   E R  + Q +       +++A L++ R L     
Sbjct: 1324 SELTTLTSQY---IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-- 1378

Query: 414  GTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPIN 473
              H       ER+   L ++++ EV++ E+     +++   ++ E +Q   ++E    I 
Sbjct: 1379 --HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE--AEIQ 1434

Query: 474  REMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEP 533
             + R   ++ ++         LR + ++R  +  L  T  + G A               
Sbjct: 1435 AKARQAEAAERSR--------LRIEEEIRVVRLQLEATERQRGGA--------------- 1471

Query: 534  AELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERERERERE-------- 585
                        +  A +A  E+A E + ++ +EE ER RR+ + E +R+R+        
Sbjct: 1472 ----------EGELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1520

Query: 586  --KEKEREREKQK-LKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQES--- 639
               E E  REKQ+ L+  E+ R  A++ E+      R+ E E  +Q+++ L+ AQ S   
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEAERRL----RQAEVERARQVQVALETAQRSAEA 1576

Query: 640  --------------------QKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAEL----- 674
                                Q+E   +  +   A +  + + +   A ++++ EL     
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1636

Query: 675  ---EDLRQRL--------KDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQ 723
               E LR RL        K L   E ++ K+ A+ +A R+ +A E+ +   Q++LA  + 
Sbjct: 1637 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR--QRELAEQEL 1694

Query: 724  EEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEE 783
            E++  L+E   T Q     +++ IRL  +  + +     L  E  +  +      ++++E
Sbjct: 1695 EKQRQLAE--GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752

Query: 784  LADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQL 843
            L  ++  ++ +++  L    + EE+         T EK      Q LE    +  E A+ 
Sbjct: 1753 LEAELAKVRAEMEVLLASKARAEEESR------STSEKS----KQRLEAEAGRFRELAEE 1802

Query: 844  ADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKK 898
            A  L+A  E A+++    +++        E+ +     A  + +RL+ + E   K
Sbjct: 1803 AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1857



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 183/903 (20%), Positives = 380/903 (42%), Gaps = 127/903 (14%)

Query: 20   EKKAAVEDSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKL 79
            EK AA    G     ++LG + S  E    TL++K +   E   QRQ   +E R   E  
Sbjct: 1935 EKAAA----GKAELELELGRIRSNAE---DTLRSKEQAELEAARQRQLAAEEERRRREAE 1987

Query: 80   ERRQAT----------DDASLLIVNRYWSQFDENIRI-------ILKRYDLEQGLGD--L 120
            ER Q +            A+L  V R  ++ +E  R+         ++  L Q      L
Sbjct: 1988 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2047

Query: 121  LTERKA--LVVPEPEPDSDSNQERKD---DRERGEGQEPAFSFLATLASSSSEEMESQLQ 175
              E KA    V + E +     +++    D+ RGE +       A  A+  +EE   Q +
Sbjct: 2048 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA------ARRAAEEAEEARVQAE 2101

Query: 176  ERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQEL--NSFLAQENMRLQ 233
                 SRR V +   +    +E+ +  ++   + + L  +EA QE    +   Q  +R +
Sbjct: 2102 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR-KEAEQEAARRAQAEQAALRQK 2160

Query: 234  ELTDLLQEKHRTMS-----------QEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIR 282
            +  D   EKH+  +           QE + L+ ++E  + + ++L+  +  L+ +  +  
Sbjct: 2161 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2220

Query: 283  KREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITI----NARKFEEMNAELEENKEL 338
            ++  ++   L  V  RV  +      A        + +    N ++F  +  E E+ K++
Sbjct: 2221 RQRSQVEEELFSV--RVQMEELSKLKARIEAENRALILRDKDNTQRF--LQEEAEKMKQV 2276

Query: 339  AQN--RLC----ELEKLRQDFEEVTTQN----EKLKVELRSAVEQVVKETPEYRCMQSQF 388
            A+   RL     E  +LRQ  EE   Q     EK+  E   AV++  +   E   +Q Q 
Sbjct: 2277 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336

Query: 389  SVLYNESLQLKAHLDE-ARTLLHGTRGTHQHQVELIERDEVSLH---KKLRTEVIQLEDT 444
             +   ++ +L+   ++ A+ L   T+G  Q  +E   + ++ +    ++L+  V ++   
Sbjct: 2337 ELAQEQARRLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2395

Query: 445  LAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREA 504
             A+  ++ +  R + E+      +     +E   L+ +L+    Q   +  R +  + E 
Sbjct: 2396 QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2455

Query: 505  QSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKAS---------QE 555
            + +  K +L+  + LLQ +S  E    +  +L  +++ L     + K S         QE
Sbjct: 2456 ERE--KEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2512

Query: 556  DANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKH 615
             A   +  +DE  + ++ RE+++ ++++ E  +ER+R    ++E+ + +  A++  + K 
Sbjct: 2513 KAKLEQLFQDEVAKAQQLREEQQRQQQQME--QERQRLVASMEEARRRQHEAEEGVRRKQ 2570

Query: 616  DDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQ-----------------R 658
            ++ ++ E +  +Q ++  ++ Q  +++++LL + +R+A                     R
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR 2630

Query: 659  DKVQLMAAEKKSKAELEDLR-----QRLKDLEDKEKKENKKMAD-EDALRKIRAVEEQIE 712
            D +   AAE + +   + LR     QRL++      +E +++A     + ++   E+   
Sbjct: 2631 DALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRH 2690

Query: 713  YLQKKLAMAKQEEEALLSEMDV------------TGQAFEDMQEQNIRLMQQLREKDDAN 760
            YLQ + ++A    +A   ++ V            T     + Q  +  L+  +R +    
Sbjct: 2691 YLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTV 2750

Query: 761  FKLMSERIKSNQI-HKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEH---LLQSNI 816
             + + E +   ++ HKLL  E+     +      Q+     + + L  +EH   LL++ I
Sbjct: 2751 NEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQI 2810

Query: 817  GTG 819
             TG
Sbjct: 2811 ATG 2813


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  125 bits (313), Expect = 3e-28
 Identities = 210/1004 (20%), Positives = 407/1004 (40%), Gaps = 164/1004 (16%)

Query: 55   NRKLAEMLDQRQAIEDELREHIEKLERRQ--------ATDDASLLIVNRYWSQFDE---- 102
            ++ + E L Q QA+ +E+  H EK+E  Q        A  D  L +V  Y +Q +     
Sbjct: 1209 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT-YKAQLEPVASP 1267

Query: 103  ---------NIRIILKRYDLEQGLGDL--LTERKALVVPE-----PEPDSDSNQERKDDR 146
                     +  +I +  DL     +L  LT +    + E      E +  + Q+R ++R
Sbjct: 1268 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1327

Query: 147  ERGEGQEPAFSFLATLASS----------SSEEMESQLQERVESSRRAVSQIVTVYDKLQ 196
            ER    E A      LA +           ++E++ ++QE V     A          +Q
Sbjct: 1328 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1387

Query: 197  EKVELLSRKLNSGDNLIVEEA-VQELNSFLAQENMRLQELTDLLQEKHRTMSQ-EFSKLQ 254
            E+++ L +   +       +A   E +    +E +R+  L     E+ R  ++ E   L+
Sbjct: 1388 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1447

Query: 255  SKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLY 314
            ++ E AE++    +   + L+  +    +R+++    LA  ++       +   A  +L 
Sbjct: 1448 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1507

Query: 315  GGTITINARKFEEMNAELEENKEL-------AQNRLCELEKLRQDFEEVTTQNEKLKVEL 367
               +     +     AE+E  +++        ++   EL+  R  F E T Q E+   E 
Sbjct: 1508 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1567

Query: 368  RSAVEQVVKETPEYRCMQ---------------SQFSVLYNESLQLKAHLDEARTLLHGT 412
              AV Q ++E  E R  Q                ++ +  NE+L+L+   +E        
Sbjct: 1568 HVAVAQ-LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1626

Query: 413  RGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPI 472
            +   + Q E  ER+     K     V Q E    ++ K+ ++     +Q LAA ++   +
Sbjct: 1627 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1686

Query: 473  NREM---RHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDP 529
              E          L+    +L+ E     +K +E +++L K R      LL S++  E+ 
Sbjct: 1687 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-EVLLASKARAEEE 1745

Query: 530  KDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERERER------- 582
                +E     + L +++   +   E+A  +++  +E +R+R+  E++  R+R       
Sbjct: 1746 SRSTSE--KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1803

Query: 583  ----------------------EREKEKERERE-----------------------KQKL 597
                                  E+E E ER R                        +++L
Sbjct: 1804 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1863

Query: 598  KESEKERDSAKDKEKGKHDD---GRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAP 654
             +  K  DS  +++KG  +D    R++  E I  LK   +KA   + E++L L   RS  
Sbjct: 1864 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1923

Query: 655  KE---QRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQI 711
            ++    +++ +L AA ++  A  E+ R+R    E +E+ +    A+E+A R+ +A  E++
Sbjct: 1924 EDTLRSKEQAELEAARQRQLAAEEERRRR----EAEERVQKSLAAEEEAARQRKAALEEV 1979

Query: 712  EYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSN 771
            E L+ K+  A++  E    E     Q  ++  ++ +    Q  EK  A     + + K  
Sbjct: 1980 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL----QAEEKAHA----FAVQQKEQ 2031

Query: 772  QIHKLLKEEKEEL-------------ADQVLTLKTQVDAQ-LQVVRKLEEKEHLLQSNIG 817
            ++ + L++E+  L             A++    + Q + +  Q  R++EE E L QS   
Sbjct: 2032 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2091

Query: 818  TGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMF 877
              +     +  A ++ K    EAA+ A     Q  L QK+  D   E+ ++    E+ + 
Sbjct: 2092 QAQARAQAQAAAEKLRKEAEQEAARRAQ--AEQAALRQKQAAD--AEMEKHKKFAEQTLR 2147

Query: 878  NFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDYKARLT 921
               + +++++ LR +LE T    N      +L EE++  KA  T
Sbjct: 2148 QKAQVEQELTTLRLQLEETDHQKN------LLDEELQRLKAEAT 2185



 Score =  102 bits (255), Expect = 1e-21
 Identities = 200/973 (20%), Positives = 390/973 (40%), Gaps = 157/973 (16%)

Query: 36   KLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNR 95
            K   + + EEL ++  + + R        RQA  +  R+    LE  Q + +A L     
Sbjct: 1499 KQRALQALEELRLQAEEAERRL-------RQAEVERARQVQVALETAQRSAEAELQSKRA 1551

Query: 96   YWSQFDENIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPA 155
             +++         K   LE+ L +   E  A+     E +  + Q+ + +R R E +   
Sbjct: 1552 SFAE---------KTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAERE- 1598

Query: 156  FSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVE 215
               L      ++E +  +LQ    + +++++Q     +K +E+ E  +R+    +    E
Sbjct: 1599 ---LERWQLKANEALRLRLQAEEVAQQKSLAQAEA--EKQKEEAEREARRRGKAE----E 1649

Query: 216  EAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQ 275
            +AV++      QE  + ++L +   ++     QE  +L+++ E  E +  +LE  +  LQ
Sbjct: 1650 QAVRQ-RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1708

Query: 276  WDIDKIRKREQRLNRHLA------EVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMN 329
             +     ++ Q L   LA      EVL    ++  +   + S      +   A +F E+ 
Sbjct: 1709 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1768

Query: 330  AELEENKELA-----QNRLCELEKLRQDFEEVTTQNEKL---------KVELRSAVEQVV 375
             E    + LA     Q +L E +  RQ  E      EKL         K E   A+++  
Sbjct: 1769 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1828

Query: 376  KETPEYRCMQS----QFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLH 431
             E    R +      Q   L  ++ Q KA ++E    L     +   + + +  D +   
Sbjct: 1829 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1888

Query: 432  KKLRTEVIQLEDTL-------AQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQ 484
            +++  E++ L+ +        A++  E   +R   E TL + EQA       R L +  +
Sbjct: 1889 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1948

Query: 485  NHNHQLKG---------------------EVLRYKRKLREAQSDLNKTRLRSGSALLQSQ 523
                + +                      EV R K K+ EA+    +    S   L  +Q
Sbjct: 1949 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2008

Query: 524  SSTEDPKDEPAELKPDS---------------------EDLSSQSSASKASQEDANEIKS 562
             + +  K   AE K  +                     + L  ++ A++ + E+A E + 
Sbjct: 2009 EAAQ--KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2066

Query: 563  KRDEEERERERREKEREREREREKEKEREREK-----QKL-KESEKERDSAKDKEKGKHD 616
            + + E  +  R+ +E ER ++  +E+ + R +     +KL KE+E+E       E+    
Sbjct: 2067 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2126

Query: 617  DGRKKEAEIIKQLKIE----LKKAQESQKEMKLLLDMYRSAPKE-------QRDKVQLMA 665
              +  +AE+ K  K       +KAQ  Q+   L L +  +  ++       QR K +   
Sbjct: 2127 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2186

Query: 666  AEKKSKAELEDL------RQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQK--- 716
            A ++     E+L       + L  L+ + + EN+ +   D     R ++E+ E +++   
Sbjct: 2187 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2246

Query: 717  ---KLAMAKQEEEAL--LSEMDVTGQ--AFEDMQEQNIRLMQQ-LREKDDANFKLMSERI 768
               +L++A QE   L  L+E D+  Q    E M ++ ++ +Q+  R K +A      + +
Sbjct: 2247 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2306

Query: 769  KSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQ 828
               Q  + L+E+KE++A Q+         + Q  ++  E E   Q  +    + L LR  
Sbjct: 2307 AQEQARR-LQEDKEQMAQQLA-------EETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2358

Query: 829  ALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVEN-------SVTKEKDMFNFKR 881
             +   + +A E AQ     + Q E   +KLH  +    E         + +++   + +R
Sbjct: 2359 EMSRAQARAEEDAQ---RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2415

Query: 882  AQEDISRLRRKLE 894
             +E I+ L R+ E
Sbjct: 2416 LREAIAELEREKE 2428



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 166/835 (19%), Positives = 338/835 (40%), Gaps = 150/835 (17%)

Query: 124  RKALVVPEPEPDSDSNQER-KDDRERGEGQEPAFSFLATLASSSSEEMESQLQER----- 177
            ++A  VP   P+ ++ +   K  R + E Q+P F  L       ++E+  +LQ+R     
Sbjct: 1081 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD-ELRGAQEVGERLQQRHGERD 1139

Query: 178  --VESSRRAVSQIVTVYDKLQEKVELLSRKLNS-GDNL-IVEEAVQELNSFLAQENMRLQ 233
              VE  R  V+Q++  +  +  + ++  R+L   G  L    E+   L ++L     R +
Sbjct: 1140 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1199

Query: 234  ELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLA 293
            ++  +     + + ++  + Q+ +E  E     +E      +  I+ I+  E +L  + A
Sbjct: 1200 QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1259

Query: 294  EVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDF 353
            + LE V S   K      S                           ++ + E   LR  +
Sbjct: 1260 Q-LEPVASPAKKPKVQSGS---------------------------ESVIQEYVDLRTHY 1291

Query: 354  EEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTR 413
             E+TT   +    ++   E + +   E R  + Q +       +++A L++ R L     
Sbjct: 1292 SELTTLTSQY---IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-- 1346

Query: 414  GTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPIN 473
              H       ER+   L ++++ EV++ E+     +++   ++ E +Q   ++E    I 
Sbjct: 1347 --HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE--AEIQ 1402

Query: 474  REMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEP 533
             + R   ++ ++         LR + ++R  +  L  T  + G A               
Sbjct: 1403 AKARQAEAAERSR--------LRIEEEIRVVRLQLEATERQRGGA--------------- 1439

Query: 534  AELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERERERERE-------- 585
                        +  A +A  E+A E + ++ +EE ER RR+ + E +R+R+        
Sbjct: 1440 ----------EGELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1488

Query: 586  --KEKEREREKQK-LKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQES--- 639
               E E  REKQ+ L+  E+ R  A++ E+      R+ E E  +Q+++ L+ AQ S   
Sbjct: 1489 VKAEAEAAREKQRALQALEELRLQAEEAERRL----RQAEVERARQVQVALETAQRSAEA 1544

Query: 640  --------------------QKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAEL----- 674
                                Q+E   +  +   A +  + + +   A ++++ EL     
Sbjct: 1545 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1604

Query: 675  ---EDLRQRL--------KDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQ 723
               E LR RL        K L   E ++ K+ A+ +A R+ +A E+ +   Q++LA  + 
Sbjct: 1605 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR--QRELAEQEL 1662

Query: 724  EEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEE 783
            E++  L+E   T Q     +++ IRL  +  + +     L  E  +  +      ++++E
Sbjct: 1663 EKQRQLAE--GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1720

Query: 784  LADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQL 843
            L  ++  ++ +++  L    + EE+         T EK      Q LE    +  E A+ 
Sbjct: 1721 LEAELAKVRAEMEVLLASKARAEEESR------STSEKS----KQRLEAEAGRFRELAEE 1770

Query: 844  ADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKK 898
            A  L+A  E A+++    +++        E+ +     A  + +RL+ + E   K
Sbjct: 1771 AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1825



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 183/903 (20%), Positives = 380/903 (42%), Gaps = 127/903 (14%)

Query: 20   EKKAAVEDSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKL 79
            EK AA    G     ++LG + S  E    TL++K +   E   QRQ   +E R   E  
Sbjct: 1903 EKAAA----GKAELELELGRIRSNAE---DTLRSKEQAELEAARQRQLAAEEERRRREAE 1955

Query: 80   ERRQAT----------DDASLLIVNRYWSQFDENIRI-------ILKRYDLEQGLGD--L 120
            ER Q +            A+L  V R  ++ +E  R+         ++  L Q      L
Sbjct: 1956 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2015

Query: 121  LTERKA--LVVPEPEPDSDSNQERKD---DRERGEGQEPAFSFLATLASSSSEEMESQLQ 175
              E KA    V + E +     +++    D+ RGE +       A  A+  +EE   Q +
Sbjct: 2016 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA------ARRAAEEAEEARVQAE 2069

Query: 176  ERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQEL--NSFLAQENMRLQ 233
                 SRR V +   +    +E+ +  ++   + + L  +EA QE    +   Q  +R +
Sbjct: 2070 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR-KEAEQEAARRAQAEQAALRQK 2128

Query: 234  ELTDLLQEKHRTMS-----------QEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIR 282
            +  D   EKH+  +           QE + L+ ++E  + + ++L+  +  L+ +  +  
Sbjct: 2129 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2188

Query: 283  KREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITI----NARKFEEMNAELEENKEL 338
            ++  ++   L  V  RV  +      A        + +    N ++F  +  E E+ K++
Sbjct: 2189 RQRSQVEEELFSV--RVQMEELSKLKARIEAENRALILRDKDNTQRF--LQEEAEKMKQV 2244

Query: 339  AQN--RLC----ELEKLRQDFEEVTTQN----EKLKVELRSAVEQVVKETPEYRCMQSQF 388
            A+   RL     E  +LRQ  EE   Q     EK+  E   AV++  +   E   +Q Q 
Sbjct: 2245 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2304

Query: 389  SVLYNESLQLKAHLDE-ARTLLHGTRGTHQHQVELIERDEVSLH---KKLRTEVIQLEDT 444
             +   ++ +L+   ++ A+ L   T+G  Q  +E   + ++ +    ++L+  V ++   
Sbjct: 2305 ELAQEQARRLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2363

Query: 445  LAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREA 504
             A+  ++ +  R + E+      +     +E   L+ +L+    Q   +  R +  + E 
Sbjct: 2364 QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2423

Query: 505  QSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKAS---------QE 555
            + +  K +L+  + LLQ +S  E    +  +L  +++ L     + K S         QE
Sbjct: 2424 ERE--KEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2480

Query: 556  DANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKH 615
             A   +  +DE  + ++ RE+++ ++++ E  +ER+R    ++E+ + +  A++  + K 
Sbjct: 2481 KAKLEQLFQDEVAKAQQLREEQQRQQQQME--QERQRLVASMEEARRRQHEAEEGVRRKQ 2538

Query: 616  DDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQ-----------------R 658
            ++ ++ E +  +Q ++  ++ Q  +++++LL + +R+A                     R
Sbjct: 2539 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR 2598

Query: 659  DKVQLMAAEKKSKAELEDLR-----QRLKDLEDKEKKENKKMAD-EDALRKIRAVEEQIE 712
            D +   AAE + +   + LR     QRL++      +E +++A     + ++   E+   
Sbjct: 2599 DALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRH 2658

Query: 713  YLQKKLAMAKQEEEALLSEMDV------------TGQAFEDMQEQNIRLMQQLREKDDAN 760
            YLQ + ++A    +A   ++ V            T     + Q  +  L+  +R +    
Sbjct: 2659 YLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTV 2718

Query: 761  FKLMSERIKSNQI-HKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEH---LLQSNI 816
             + + E +   ++ HKLL  E+     +      Q+     + + L  +EH   LL++ I
Sbjct: 2719 NEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQI 2778

Query: 817  GTG 819
             TG
Sbjct: 2779 ATG 2781


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  125 bits (313), Expect = 3e-28
 Identities = 210/1004 (20%), Positives = 407/1004 (40%), Gaps = 164/1004 (16%)

Query: 55   NRKLAEMLDQRQAIEDELREHIEKLERRQ--------ATDDASLLIVNRYWSQFDE---- 102
            ++ + E L Q QA+ +E+  H EK+E  Q        A  D  L +V  Y +Q +     
Sbjct: 1378 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT-YKAQLEPVASP 1436

Query: 103  ---------NIRIILKRYDLEQGLGDL--LTERKALVVPE-----PEPDSDSNQERKDDR 146
                     +  +I +  DL     +L  LT +    + E      E +  + Q+R ++R
Sbjct: 1437 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1496

Query: 147  ERGEGQEPAFSFLATLASS----------SSEEMESQLQERVESSRRAVSQIVTVYDKLQ 196
            ER    E A      LA +           ++E++ ++QE V     A          +Q
Sbjct: 1497 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1556

Query: 197  EKVELLSRKLNSGDNLIVEEA-VQELNSFLAQENMRLQELTDLLQEKHRTMSQ-EFSKLQ 254
            E+++ L +   +       +A   E +    +E +R+  L     E+ R  ++ E   L+
Sbjct: 1557 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1616

Query: 255  SKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLY 314
            ++ E AE++    +   + L+  +    +R+++    LA  ++       +   A  +L 
Sbjct: 1617 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1676

Query: 315  GGTITINARKFEEMNAELEENKEL-------AQNRLCELEKLRQDFEEVTTQNEKLKVEL 367
               +     +     AE+E  +++        ++   EL+  R  F E T Q E+   E 
Sbjct: 1677 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1736

Query: 368  RSAVEQVVKETPEYRCMQ---------------SQFSVLYNESLQLKAHLDEARTLLHGT 412
              AV Q ++E  E R  Q                ++ +  NE+L+L+   +E        
Sbjct: 1737 HVAVAQ-LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1795

Query: 413  RGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPI 472
            +   + Q E  ER+     K     V Q E    ++ K+ ++     +Q LAA ++   +
Sbjct: 1796 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1855

Query: 473  NREM---RHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDP 529
              E          L+    +L+ E     +K +E +++L K R      LL S++  E+ 
Sbjct: 1856 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-EVLLASKARAEEE 1914

Query: 530  KDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERERER------- 582
                +E     + L +++   +   E+A  +++  +E +R+R+  E++  R+R       
Sbjct: 1915 SRSTSE--KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1972

Query: 583  ----------------------EREKEKERERE-----------------------KQKL 597
                                  E+E E ER R                        +++L
Sbjct: 1973 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 2032

Query: 598  KESEKERDSAKDKEKGKHDD---GRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAP 654
             +  K  DS  +++KG  +D    R++  E I  LK   +KA   + E++L L   RS  
Sbjct: 2033 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 2092

Query: 655  KE---QRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQI 711
            ++    +++ +L AA ++  A  E+ R+R    E +E+ +    A+E+A R+ +A  E++
Sbjct: 2093 EDTLRSKEQAELEAARQRQLAAEEERRRR----EAEERVQKSLAAEEEAARQRKAALEEV 2148

Query: 712  EYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSN 771
            E L+ K+  A++  E    E     Q  ++  ++ +    Q  EK  A     + + K  
Sbjct: 2149 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL----QAEEKAHA----FAVQQKEQ 2200

Query: 772  QIHKLLKEEKEEL-------------ADQVLTLKTQVDAQ-LQVVRKLEEKEHLLQSNIG 817
            ++ + L++E+  L             A++    + Q + +  Q  R++EE E L QS   
Sbjct: 2201 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2260

Query: 818  TGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMF 877
              +     +  A ++ K    EAA+ A     Q  L QK+  D   E+ ++    E+ + 
Sbjct: 2261 QAQARAQAQAAAEKLRKEAEQEAARRAQ--AEQAALRQKQAAD--AEMEKHKKFAEQTLR 2316

Query: 878  NFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDYKARLT 921
               + +++++ LR +LE T    N      +L EE++  KA  T
Sbjct: 2317 QKAQVEQELTTLRLQLEETDHQKN------LLDEELQRLKAEAT 2354



 Score =  102 bits (255), Expect = 1e-21
 Identities = 200/973 (20%), Positives = 390/973 (40%), Gaps = 157/973 (16%)

Query: 36   KLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNR 95
            K   + + EEL ++  + + R        RQA  +  R+    LE  Q + +A L     
Sbjct: 1668 KQRALQALEELRLQAEEAERRL-------RQAEVERARQVQVALETAQRSAEAELQSKRA 1720

Query: 96   YWSQFDENIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPA 155
             +++         K   LE+ L +   E  A+     E +  + Q+ + +R R E +   
Sbjct: 1721 SFAE---------KTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAERE- 1767

Query: 156  FSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVE 215
               L      ++E +  +LQ    + +++++Q     +K +E+ E  +R+    +    E
Sbjct: 1768 ---LERWQLKANEALRLRLQAEEVAQQKSLAQAEA--EKQKEEAEREARRRGKAE----E 1818

Query: 216  EAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQ 275
            +AV++      QE  + ++L +   ++     QE  +L+++ E  E +  +LE  +  LQ
Sbjct: 1819 QAVRQ-RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1877

Query: 276  WDIDKIRKREQRLNRHLA------EVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMN 329
             +     ++ Q L   LA      EVL    ++  +   + S      +   A +F E+ 
Sbjct: 1878 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1937

Query: 330  AELEENKELA-----QNRLCELEKLRQDFEEVTTQNEKL---------KVELRSAVEQVV 375
             E    + LA     Q +L E +  RQ  E      EKL         K E   A+++  
Sbjct: 1938 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1997

Query: 376  KETPEYRCMQS----QFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLH 431
             E    R +      Q   L  ++ Q KA ++E    L     +   + + +  D +   
Sbjct: 1998 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 2057

Query: 432  KKLRTEVIQLEDTL-------AQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQ 484
            +++  E++ L+ +        A++  E   +R   E TL + EQA       R L +  +
Sbjct: 2058 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2117

Query: 485  NHNHQLKG---------------------EVLRYKRKLREAQSDLNKTRLRSGSALLQSQ 523
                + +                      EV R K K+ EA+    +    S   L  +Q
Sbjct: 2118 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2177

Query: 524  SSTEDPKDEPAELKPDS---------------------EDLSSQSSASKASQEDANEIKS 562
             + +  K   AE K  +                     + L  ++ A++ + E+A E + 
Sbjct: 2178 EAAQ--KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2235

Query: 563  KRDEEERERERREKEREREREREKEKEREREK-----QKL-KESEKERDSAKDKEKGKHD 616
            + + E  +  R+ +E ER ++  +E+ + R +     +KL KE+E+E       E+    
Sbjct: 2236 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2295

Query: 617  DGRKKEAEIIKQLKIE----LKKAQESQKEMKLLLDMYRSAPKE-------QRDKVQLMA 665
              +  +AE+ K  K       +KAQ  Q+   L L +  +  ++       QR K +   
Sbjct: 2296 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2355

Query: 666  AEKKSKAELEDL------RQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQK--- 716
            A ++     E+L       + L  L+ + + EN+ +   D     R ++E+ E +++   
Sbjct: 2356 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2415

Query: 717  ---KLAMAKQEEEAL--LSEMDVTGQ--AFEDMQEQNIRLMQQ-LREKDDANFKLMSERI 768
               +L++A QE   L  L+E D+  Q    E M ++ ++ +Q+  R K +A      + +
Sbjct: 2416 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2475

Query: 769  KSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQ 828
               Q  + L+E+KE++A Q+         + Q  ++  E E   Q  +    + L LR  
Sbjct: 2476 AQEQARR-LQEDKEQMAQQLA-------EETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2527

Query: 829  ALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVEN-------SVTKEKDMFNFKR 881
             +   + +A E AQ     + Q E   +KLH  +    E         + +++   + +R
Sbjct: 2528 EMSRAQARAEEDAQ---RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2584

Query: 882  AQEDISRLRRKLE 894
             +E I+ L R+ E
Sbjct: 2585 LREAIAELEREKE 2597



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 166/835 (19%), Positives = 338/835 (40%), Gaps = 150/835 (17%)

Query: 124  RKALVVPEPEPDSDSNQER-KDDRERGEGQEPAFSFLATLASSSSEEMESQLQER----- 177
            ++A  VP   P+ ++ +   K  R + E Q+P F  L       ++E+  +LQ+R     
Sbjct: 1250 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD-ELRGAQEVGERLQQRHGERD 1308

Query: 178  --VESSRRAVSQIVTVYDKLQEKVELLSRKLNS-GDNL-IVEEAVQELNSFLAQENMRLQ 233
              VE  R  V+Q++  +  +  + ++  R+L   G  L    E+   L ++L     R +
Sbjct: 1309 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1368

Query: 234  ELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLA 293
            ++  +     + + ++  + Q+ +E  E     +E      +  I+ I+  E +L  + A
Sbjct: 1369 QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1428

Query: 294  EVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDF 353
            + LE V S   K      S                           ++ + E   LR  +
Sbjct: 1429 Q-LEPVASPAKKPKVQSGS---------------------------ESVIQEYVDLRTHY 1460

Query: 354  EEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTR 413
             E+TT   +    ++   E + +   E R  + Q +       +++A L++ R L     
Sbjct: 1461 SELTTLTSQY---IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-- 1515

Query: 414  GTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPIN 473
              H       ER+   L ++++ EV++ E+     +++   ++ E +Q   ++E    I 
Sbjct: 1516 --HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE--AEIQ 1571

Query: 474  REMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEP 533
             + R   ++ ++         LR + ++R  +  L  T  + G A               
Sbjct: 1572 AKARQAEAAERSR--------LRIEEEIRVVRLQLEATERQRGGA--------------- 1608

Query: 534  AELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERERERERE-------- 585
                        +  A +A  E+A E + ++ +EE ER RR+ + E +R+R+        
Sbjct: 1609 ----------EGELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1657

Query: 586  --KEKEREREKQK-LKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQES--- 639
               E E  REKQ+ L+  E+ R  A++ E+      R+ E E  +Q+++ L+ AQ S   
Sbjct: 1658 VKAEAEAAREKQRALQALEELRLQAEEAERRL----RQAEVERARQVQVALETAQRSAEA 1713

Query: 640  --------------------QKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAEL----- 674
                                Q+E   +  +   A +  + + +   A ++++ EL     
Sbjct: 1714 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1773

Query: 675  ---EDLRQRL--------KDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQ 723
               E LR RL        K L   E ++ K+ A+ +A R+ +A E+ +   Q++LA  + 
Sbjct: 1774 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR--QRELAEQEL 1831

Query: 724  EEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEE 783
            E++  L+E   T Q     +++ IRL  +  + +     L  E  +  +      ++++E
Sbjct: 1832 EKQRQLAE--GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1889

Query: 784  LADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQL 843
            L  ++  ++ +++  L    + EE+         T EK      Q LE    +  E A+ 
Sbjct: 1890 LEAELAKVRAEMEVLLASKARAEEESR------STSEKS----KQRLEAEAGRFRELAEE 1939

Query: 844  ADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKK 898
            A  L+A  E A+++    +++        E+ +     A  + +RL+ + E   K
Sbjct: 1940 AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1994



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 183/903 (20%), Positives = 380/903 (42%), Gaps = 127/903 (14%)

Query: 20   EKKAAVEDSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKL 79
            EK AA    G     ++LG + S  E    TL++K +   E   QRQ   +E R   E  
Sbjct: 2072 EKAAA----GKAELELELGRIRSNAE---DTLRSKEQAELEAARQRQLAAEEERRRREAE 2124

Query: 80   ERRQAT----------DDASLLIVNRYWSQFDENIRI-------ILKRYDLEQGLGD--L 120
            ER Q +            A+L  V R  ++ +E  R+         ++  L Q      L
Sbjct: 2125 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2184

Query: 121  LTERKA--LVVPEPEPDSDSNQERKD---DRERGEGQEPAFSFLATLASSSSEEMESQLQ 175
              E KA    V + E +     +++    D+ RGE +       A  A+  +EE   Q +
Sbjct: 2185 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA------ARRAAEEAEEARVQAE 2238

Query: 176  ERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQEL--NSFLAQENMRLQ 233
                 SRR V +   +    +E+ +  ++   + + L  +EA QE    +   Q  +R +
Sbjct: 2239 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR-KEAEQEAARRAQAEQAALRQK 2297

Query: 234  ELTDLLQEKHRTMS-----------QEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIR 282
            +  D   EKH+  +           QE + L+ ++E  + + ++L+  +  L+ +  +  
Sbjct: 2298 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2357

Query: 283  KREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITI----NARKFEEMNAELEENKEL 338
            ++  ++   L  V  RV  +      A        + +    N ++F  +  E E+ K++
Sbjct: 2358 RQRSQVEEELFSV--RVQMEELSKLKARIEAENRALILRDKDNTQRF--LQEEAEKMKQV 2413

Query: 339  AQN--RLC----ELEKLRQDFEEVTTQN----EKLKVELRSAVEQVVKETPEYRCMQSQF 388
            A+   RL     E  +LRQ  EE   Q     EK+  E   AV++  +   E   +Q Q 
Sbjct: 2414 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2473

Query: 389  SVLYNESLQLKAHLDE-ARTLLHGTRGTHQHQVELIERDEVSLH---KKLRTEVIQLEDT 444
             +   ++ +L+   ++ A+ L   T+G  Q  +E   + ++ +    ++L+  V ++   
Sbjct: 2474 ELAQEQARRLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2532

Query: 445  LAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREA 504
             A+  ++ +  R + E+      +     +E   L+ +L+    Q   +  R +  + E 
Sbjct: 2533 QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2592

Query: 505  QSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKAS---------QE 555
            + +  K +L+  + LLQ +S  E    +  +L  +++ L     + K S         QE
Sbjct: 2593 ERE--KEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2649

Query: 556  DANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKH 615
             A   +  +DE  + ++ RE+++ ++++ E  +ER+R    ++E+ + +  A++  + K 
Sbjct: 2650 KAKLEQLFQDEVAKAQQLREEQQRQQQQME--QERQRLVASMEEARRRQHEAEEGVRRKQ 2707

Query: 616  DDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQ-----------------R 658
            ++ ++ E +  +Q ++  ++ Q  +++++LL + +R+A                     R
Sbjct: 2708 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR 2767

Query: 659  DKVQLMAAEKKSKAELEDLR-----QRLKDLEDKEKKENKKMAD-EDALRKIRAVEEQIE 712
            D +   AAE + +   + LR     QRL++      +E +++A     + ++   E+   
Sbjct: 2768 DALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRH 2827

Query: 713  YLQKKLAMAKQEEEALLSEMDV------------TGQAFEDMQEQNIRLMQQLREKDDAN 760
            YLQ + ++A    +A   ++ V            T     + Q  +  L+  +R +    
Sbjct: 2828 YLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTV 2887

Query: 761  FKLMSERIKSNQI-HKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEH---LLQSNI 816
             + + E +   ++ HKLL  E+     +      Q+     + + L  +EH   LL++ I
Sbjct: 2888 NEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQI 2947

Query: 817  GTG 819
             TG
Sbjct: 2948 ATG 2950


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  125 bits (313), Expect = 3e-28
 Identities = 210/1004 (20%), Positives = 407/1004 (40%), Gaps = 164/1004 (16%)

Query: 55   NRKLAEMLDQRQAIEDELREHIEKLERRQ--------ATDDASLLIVNRYWSQFDE---- 102
            ++ + E L Q QA+ +E+  H EK+E  Q        A  D  L +V  Y +Q +     
Sbjct: 1219 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT-YKAQLEPVASP 1277

Query: 103  ---------NIRIILKRYDLEQGLGDL--LTERKALVVPE-----PEPDSDSNQERKDDR 146
                     +  +I +  DL     +L  LT +    + E      E +  + Q+R ++R
Sbjct: 1278 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1337

Query: 147  ERGEGQEPAFSFLATLASS----------SSEEMESQLQERVESSRRAVSQIVTVYDKLQ 196
            ER    E A      LA +           ++E++ ++QE V     A          +Q
Sbjct: 1338 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1397

Query: 197  EKVELLSRKLNSGDNLIVEEA-VQELNSFLAQENMRLQELTDLLQEKHRTMSQ-EFSKLQ 254
            E+++ L +   +       +A   E +    +E +R+  L     E+ R  ++ E   L+
Sbjct: 1398 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1457

Query: 255  SKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLY 314
            ++ E AE++    +   + L+  +    +R+++    LA  ++       +   A  +L 
Sbjct: 1458 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1517

Query: 315  GGTITINARKFEEMNAELEENKEL-------AQNRLCELEKLRQDFEEVTTQNEKLKVEL 367
               +     +     AE+E  +++        ++   EL+  R  F E T Q E+   E 
Sbjct: 1518 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1577

Query: 368  RSAVEQVVKETPEYRCMQ---------------SQFSVLYNESLQLKAHLDEARTLLHGT 412
              AV Q ++E  E R  Q                ++ +  NE+L+L+   +E        
Sbjct: 1578 HVAVAQ-LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1636

Query: 413  RGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPI 472
            +   + Q E  ER+     K     V Q E    ++ K+ ++     +Q LAA ++   +
Sbjct: 1637 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1696

Query: 473  NREM---RHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDP 529
              E          L+    +L+ E     +K +E +++L K R      LL S++  E+ 
Sbjct: 1697 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-EVLLASKARAEEE 1755

Query: 530  KDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERERER------- 582
                +E     + L +++   +   E+A  +++  +E +R+R+  E++  R+R       
Sbjct: 1756 SRSTSE--KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1813

Query: 583  ----------------------EREKEKERERE-----------------------KQKL 597
                                  E+E E ER R                        +++L
Sbjct: 1814 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1873

Query: 598  KESEKERDSAKDKEKGKHDD---GRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAP 654
             +  K  DS  +++KG  +D    R++  E I  LK   +KA   + E++L L   RS  
Sbjct: 1874 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1933

Query: 655  KE---QRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQI 711
            ++    +++ +L AA ++  A  E+ R+R    E +E+ +    A+E+A R+ +A  E++
Sbjct: 1934 EDTLRSKEQAELEAARQRQLAAEEERRRR----EAEERVQKSLAAEEEAARQRKAALEEV 1989

Query: 712  EYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSN 771
            E L+ K+  A++  E    E     Q  ++  ++ +    Q  EK  A     + + K  
Sbjct: 1990 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL----QAEEKAHA----FAVQQKEQ 2041

Query: 772  QIHKLLKEEKEEL-------------ADQVLTLKTQVDAQ-LQVVRKLEEKEHLLQSNIG 817
            ++ + L++E+  L             A++    + Q + +  Q  R++EE E L QS   
Sbjct: 2042 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2101

Query: 818  TGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMF 877
              +     +  A ++ K    EAA+ A     Q  L QK+  D   E+ ++    E+ + 
Sbjct: 2102 QAQARAQAQAAAEKLRKEAEQEAARRAQ--AEQAALRQKQAAD--AEMEKHKKFAEQTLR 2157

Query: 878  NFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDYKARLT 921
               + +++++ LR +LE T    N      +L EE++  KA  T
Sbjct: 2158 QKAQVEQELTTLRLQLEETDHQKN------LLDEELQRLKAEAT 2195



 Score =  102 bits (255), Expect = 1e-21
 Identities = 200/973 (20%), Positives = 390/973 (40%), Gaps = 157/973 (16%)

Query: 36   KLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNR 95
            K   + + EEL ++  + + R        RQA  +  R+    LE  Q + +A L     
Sbjct: 1509 KQRALQALEELRLQAEEAERRL-------RQAEVERARQVQVALETAQRSAEAELQSKRA 1561

Query: 96   YWSQFDENIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPA 155
             +++         K   LE+ L +   E  A+     E +  + Q+ + +R R E +   
Sbjct: 1562 SFAE---------KTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAERE- 1608

Query: 156  FSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVE 215
               L      ++E +  +LQ    + +++++Q     +K +E+ E  +R+    +    E
Sbjct: 1609 ---LERWQLKANEALRLRLQAEEVAQQKSLAQAEA--EKQKEEAEREARRRGKAE----E 1659

Query: 216  EAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQ 275
            +AV++      QE  + ++L +   ++     QE  +L+++ E  E +  +LE  +  LQ
Sbjct: 1660 QAVRQ-RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1718

Query: 276  WDIDKIRKREQRLNRHLA------EVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMN 329
             +     ++ Q L   LA      EVL    ++  +   + S      +   A +F E+ 
Sbjct: 1719 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1778

Query: 330  AELEENKELA-----QNRLCELEKLRQDFEEVTTQNEKL---------KVELRSAVEQVV 375
             E    + LA     Q +L E +  RQ  E      EKL         K E   A+++  
Sbjct: 1779 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1838

Query: 376  KETPEYRCMQS----QFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLH 431
             E    R +      Q   L  ++ Q KA ++E    L     +   + + +  D +   
Sbjct: 1839 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1898

Query: 432  KKLRTEVIQLEDTL-------AQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQ 484
            +++  E++ L+ +        A++  E   +R   E TL + EQA       R L +  +
Sbjct: 1899 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1958

Query: 485  NHNHQLKG---------------------EVLRYKRKLREAQSDLNKTRLRSGSALLQSQ 523
                + +                      EV R K K+ EA+    +    S   L  +Q
Sbjct: 1959 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2018

Query: 524  SSTEDPKDEPAELKPDS---------------------EDLSSQSSASKASQEDANEIKS 562
             + +  K   AE K  +                     + L  ++ A++ + E+A E + 
Sbjct: 2019 EAAQ--KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2076

Query: 563  KRDEEERERERREKEREREREREKEKEREREK-----QKL-KESEKERDSAKDKEKGKHD 616
            + + E  +  R+ +E ER ++  +E+ + R +     +KL KE+E+E       E+    
Sbjct: 2077 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2136

Query: 617  DGRKKEAEIIKQLKIE----LKKAQESQKEMKLLLDMYRSAPKE-------QRDKVQLMA 665
              +  +AE+ K  K       +KAQ  Q+   L L +  +  ++       QR K +   
Sbjct: 2137 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2196

Query: 666  AEKKSKAELEDL------RQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQK--- 716
            A ++     E+L       + L  L+ + + EN+ +   D     R ++E+ E +++   
Sbjct: 2197 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2256

Query: 717  ---KLAMAKQEEEAL--LSEMDVTGQ--AFEDMQEQNIRLMQQ-LREKDDANFKLMSERI 768
               +L++A QE   L  L+E D+  Q    E M ++ ++ +Q+  R K +A      + +
Sbjct: 2257 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2316

Query: 769  KSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQ 828
               Q  + L+E+KE++A Q+         + Q  ++  E E   Q  +    + L LR  
Sbjct: 2317 AQEQARR-LQEDKEQMAQQLA-------EETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2368

Query: 829  ALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVEN-------SVTKEKDMFNFKR 881
             +   + +A E AQ     + Q E   +KLH  +    E         + +++   + +R
Sbjct: 2369 EMSRAQARAEEDAQ---RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2425

Query: 882  AQEDISRLRRKLE 894
             +E I+ L R+ E
Sbjct: 2426 LREAIAELEREKE 2438



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 166/835 (19%), Positives = 338/835 (40%), Gaps = 150/835 (17%)

Query: 124  RKALVVPEPEPDSDSNQER-KDDRERGEGQEPAFSFLATLASSSSEEMESQLQER----- 177
            ++A  VP   P+ ++ +   K  R + E Q+P F  L       ++E+  +LQ+R     
Sbjct: 1091 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD-ELRGAQEVGERLQQRHGERD 1149

Query: 178  --VESSRRAVSQIVTVYDKLQEKVELLSRKLNS-GDNL-IVEEAVQELNSFLAQENMRLQ 233
              VE  R  V+Q++  +  +  + ++  R+L   G  L    E+   L ++L     R +
Sbjct: 1150 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1209

Query: 234  ELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLA 293
            ++  +     + + ++  + Q+ +E  E     +E      +  I+ I+  E +L  + A
Sbjct: 1210 QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1269

Query: 294  EVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDF 353
            + LE V S   K      S                           ++ + E   LR  +
Sbjct: 1270 Q-LEPVASPAKKPKVQSGS---------------------------ESVIQEYVDLRTHY 1301

Query: 354  EEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTR 413
             E+TT   +    ++   E + +   E R  + Q +       +++A L++ R L     
Sbjct: 1302 SELTTLTSQY---IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-- 1356

Query: 414  GTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPIN 473
              H       ER+   L ++++ EV++ E+     +++   ++ E +Q   ++E    I 
Sbjct: 1357 --HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE--AEIQ 1412

Query: 474  REMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEP 533
             + R   ++ ++         LR + ++R  +  L  T  + G A               
Sbjct: 1413 AKARQAEAAERSR--------LRIEEEIRVVRLQLEATERQRGGA--------------- 1449

Query: 534  AELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERERERERE-------- 585
                        +  A +A  E+A E + ++ +EE ER RR+ + E +R+R+        
Sbjct: 1450 ----------EGELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1498

Query: 586  --KEKEREREKQK-LKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQES--- 639
               E E  REKQ+ L+  E+ R  A++ E+      R+ E E  +Q+++ L+ AQ S   
Sbjct: 1499 VKAEAEAAREKQRALQALEELRLQAEEAERRL----RQAEVERARQVQVALETAQRSAEA 1554

Query: 640  --------------------QKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAEL----- 674
                                Q+E   +  +   A +  + + +   A ++++ EL     
Sbjct: 1555 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1614

Query: 675  ---EDLRQRL--------KDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQ 723
               E LR RL        K L   E ++ K+ A+ +A R+ +A E+ +   Q++LA  + 
Sbjct: 1615 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR--QRELAEQEL 1672

Query: 724  EEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEE 783
            E++  L+E   T Q     +++ IRL  +  + +     L  E  +  +      ++++E
Sbjct: 1673 EKQRQLAE--GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1730

Query: 784  LADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQL 843
            L  ++  ++ +++  L    + EE+         T EK      Q LE    +  E A+ 
Sbjct: 1731 LEAELAKVRAEMEVLLASKARAEEESR------STSEKS----KQRLEAEAGRFRELAEE 1780

Query: 844  ADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKK 898
            A  L+A  E A+++    +++        E+ +     A  + +RL+ + E   K
Sbjct: 1781 AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1835



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 183/903 (20%), Positives = 380/903 (42%), Gaps = 127/903 (14%)

Query: 20   EKKAAVEDSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKL 79
            EK AA    G     ++LG + S  E    TL++K +   E   QRQ   +E R   E  
Sbjct: 1913 EKAAA----GKAELELELGRIRSNAE---DTLRSKEQAELEAARQRQLAAEEERRRREAE 1965

Query: 80   ERRQAT----------DDASLLIVNRYWSQFDENIRI-------ILKRYDLEQGLGD--L 120
            ER Q +            A+L  V R  ++ +E  R+         ++  L Q      L
Sbjct: 1966 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2025

Query: 121  LTERKA--LVVPEPEPDSDSNQERKD---DRERGEGQEPAFSFLATLASSSSEEMESQLQ 175
              E KA    V + E +     +++    D+ RGE +       A  A+  +EE   Q +
Sbjct: 2026 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA------ARRAAEEAEEARVQAE 2079

Query: 176  ERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQEL--NSFLAQENMRLQ 233
                 SRR V +   +    +E+ +  ++   + + L  +EA QE    +   Q  +R +
Sbjct: 2080 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR-KEAEQEAARRAQAEQAALRQK 2138

Query: 234  ELTDLLQEKHRTMS-----------QEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIR 282
            +  D   EKH+  +           QE + L+ ++E  + + ++L+  +  L+ +  +  
Sbjct: 2139 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2198

Query: 283  KREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITI----NARKFEEMNAELEENKEL 338
            ++  ++   L  V  RV  +      A        + +    N ++F  +  E E+ K++
Sbjct: 2199 RQRSQVEEELFSV--RVQMEELSKLKARIEAENRALILRDKDNTQRF--LQEEAEKMKQV 2254

Query: 339  AQN--RLC----ELEKLRQDFEEVTTQN----EKLKVELRSAVEQVVKETPEYRCMQSQF 388
            A+   RL     E  +LRQ  EE   Q     EK+  E   AV++  +   E   +Q Q 
Sbjct: 2255 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2314

Query: 389  SVLYNESLQLKAHLDE-ARTLLHGTRGTHQHQVELIERDEVSLH---KKLRTEVIQLEDT 444
             +   ++ +L+   ++ A+ L   T+G  Q  +E   + ++ +    ++L+  V ++   
Sbjct: 2315 ELAQEQARRLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2373

Query: 445  LAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREA 504
             A+  ++ +  R + E+      +     +E   L+ +L+    Q   +  R +  + E 
Sbjct: 2374 QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2433

Query: 505  QSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKAS---------QE 555
            + +  K +L+  + LLQ +S  E    +  +L  +++ L     + K S         QE
Sbjct: 2434 ERE--KEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2490

Query: 556  DANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKH 615
             A   +  +DE  + ++ RE+++ ++++ E  +ER+R    ++E+ + +  A++  + K 
Sbjct: 2491 KAKLEQLFQDEVAKAQQLREEQQRQQQQME--QERQRLVASMEEARRRQHEAEEGVRRKQ 2548

Query: 616  DDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQ-----------------R 658
            ++ ++ E +  +Q ++  ++ Q  +++++LL + +R+A                     R
Sbjct: 2549 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR 2608

Query: 659  DKVQLMAAEKKSKAELEDLR-----QRLKDLEDKEKKENKKMAD-EDALRKIRAVEEQIE 712
            D +   AAE + +   + LR     QRL++      +E +++A     + ++   E+   
Sbjct: 2609 DALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRH 2668

Query: 713  YLQKKLAMAKQEEEALLSEMDV------------TGQAFEDMQEQNIRLMQQLREKDDAN 760
            YLQ + ++A    +A   ++ V            T     + Q  +  L+  +R +    
Sbjct: 2669 YLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTV 2728

Query: 761  FKLMSERIKSNQI-HKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEH---LLQSNI 816
             + + E +   ++ HKLL  E+     +      Q+     + + L  +EH   LL++ I
Sbjct: 2729 NEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQI 2788

Query: 817  GTG 819
             TG
Sbjct: 2789 ATG 2791


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  125 bits (313), Expect = 3e-28
 Identities = 210/1004 (20%), Positives = 407/1004 (40%), Gaps = 164/1004 (16%)

Query: 55   NRKLAEMLDQRQAIEDELREHIEKLERRQ--------ATDDASLLIVNRYWSQFDE---- 102
            ++ + E L Q QA+ +E+  H EK+E  Q        A  D  L +V  Y +Q +     
Sbjct: 1227 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT-YKAQLEPVASP 1285

Query: 103  ---------NIRIILKRYDLEQGLGDL--LTERKALVVPE-----PEPDSDSNQERKDDR 146
                     +  +I +  DL     +L  LT +    + E      E +  + Q+R ++R
Sbjct: 1286 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1345

Query: 147  ERGEGQEPAFSFLATLASS----------SSEEMESQLQERVESSRRAVSQIVTVYDKLQ 196
            ER    E A      LA +           ++E++ ++QE V     A          +Q
Sbjct: 1346 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1405

Query: 197  EKVELLSRKLNSGDNLIVEEA-VQELNSFLAQENMRLQELTDLLQEKHRTMSQ-EFSKLQ 254
            E+++ L +   +       +A   E +    +E +R+  L     E+ R  ++ E   L+
Sbjct: 1406 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1465

Query: 255  SKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLY 314
            ++ E AE++    +   + L+  +    +R+++    LA  ++       +   A  +L 
Sbjct: 1466 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1525

Query: 315  GGTITINARKFEEMNAELEENKEL-------AQNRLCELEKLRQDFEEVTTQNEKLKVEL 367
               +     +     AE+E  +++        ++   EL+  R  F E T Q E+   E 
Sbjct: 1526 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1585

Query: 368  RSAVEQVVKETPEYRCMQ---------------SQFSVLYNESLQLKAHLDEARTLLHGT 412
              AV Q ++E  E R  Q                ++ +  NE+L+L+   +E        
Sbjct: 1586 HVAVAQ-LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1644

Query: 413  RGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPI 472
            +   + Q E  ER+     K     V Q E    ++ K+ ++     +Q LAA ++   +
Sbjct: 1645 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1704

Query: 473  NREM---RHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDP 529
              E          L+    +L+ E     +K +E +++L K R      LL S++  E+ 
Sbjct: 1705 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-EVLLASKARAEEE 1763

Query: 530  KDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERERER------- 582
                +E     + L +++   +   E+A  +++  +E +R+R+  E++  R+R       
Sbjct: 1764 SRSTSE--KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1821

Query: 583  ----------------------EREKEKERERE-----------------------KQKL 597
                                  E+E E ER R                        +++L
Sbjct: 1822 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1881

Query: 598  KESEKERDSAKDKEKGKHDD---GRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAP 654
             +  K  DS  +++KG  +D    R++  E I  LK   +KA   + E++L L   RS  
Sbjct: 1882 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1941

Query: 655  KE---QRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQI 711
            ++    +++ +L AA ++  A  E+ R+R    E +E+ +    A+E+A R+ +A  E++
Sbjct: 1942 EDTLRSKEQAELEAARQRQLAAEEERRRR----EAEERVQKSLAAEEEAARQRKAALEEV 1997

Query: 712  EYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSN 771
            E L+ K+  A++  E    E     Q  ++  ++ +    Q  EK  A     + + K  
Sbjct: 1998 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL----QAEEKAHA----FAVQQKEQ 2049

Query: 772  QIHKLLKEEKEEL-------------ADQVLTLKTQVDAQ-LQVVRKLEEKEHLLQSNIG 817
            ++ + L++E+  L             A++    + Q + +  Q  R++EE E L QS   
Sbjct: 2050 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2109

Query: 818  TGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMF 877
              +     +  A ++ K    EAA+ A     Q  L QK+  D   E+ ++    E+ + 
Sbjct: 2110 QAQARAQAQAAAEKLRKEAEQEAARRAQ--AEQAALRQKQAAD--AEMEKHKKFAEQTLR 2165

Query: 878  NFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDYKARLT 921
               + +++++ LR +LE T    N      +L EE++  KA  T
Sbjct: 2166 QKAQVEQELTTLRLQLEETDHQKN------LLDEELQRLKAEAT 2203



 Score =  102 bits (255), Expect = 1e-21
 Identities = 200/973 (20%), Positives = 390/973 (40%), Gaps = 157/973 (16%)

Query: 36   KLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNR 95
            K   + + EEL ++  + + R        RQA  +  R+    LE  Q + +A L     
Sbjct: 1517 KQRALQALEELRLQAEEAERRL-------RQAEVERARQVQVALETAQRSAEAELQSKRA 1569

Query: 96   YWSQFDENIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPA 155
             +++         K   LE+ L +   E  A+     E +  + Q+ + +R R E +   
Sbjct: 1570 SFAE---------KTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAERE- 1616

Query: 156  FSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVE 215
               L      ++E +  +LQ    + +++++Q     +K +E+ E  +R+    +    E
Sbjct: 1617 ---LERWQLKANEALRLRLQAEEVAQQKSLAQAEA--EKQKEEAEREARRRGKAE----E 1667

Query: 216  EAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQ 275
            +AV++      QE  + ++L +   ++     QE  +L+++ E  E +  +LE  +  LQ
Sbjct: 1668 QAVRQ-RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1726

Query: 276  WDIDKIRKREQRLNRHLA------EVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMN 329
             +     ++ Q L   LA      EVL    ++  +   + S      +   A +F E+ 
Sbjct: 1727 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1786

Query: 330  AELEENKELA-----QNRLCELEKLRQDFEEVTTQNEKL---------KVELRSAVEQVV 375
             E    + LA     Q +L E +  RQ  E      EKL         K E   A+++  
Sbjct: 1787 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1846

Query: 376  KETPEYRCMQS----QFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLH 431
             E    R +      Q   L  ++ Q KA ++E    L     +   + + +  D +   
Sbjct: 1847 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1906

Query: 432  KKLRTEVIQLEDTL-------AQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQ 484
            +++  E++ L+ +        A++  E   +R   E TL + EQA       R L +  +
Sbjct: 1907 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1966

Query: 485  NHNHQLKG---------------------EVLRYKRKLREAQSDLNKTRLRSGSALLQSQ 523
                + +                      EV R K K+ EA+    +    S   L  +Q
Sbjct: 1967 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2026

Query: 524  SSTEDPKDEPAELKPDS---------------------EDLSSQSSASKASQEDANEIKS 562
             + +  K   AE K  +                     + L  ++ A++ + E+A E + 
Sbjct: 2027 EAAQ--KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2084

Query: 563  KRDEEERERERREKEREREREREKEKEREREK-----QKL-KESEKERDSAKDKEKGKHD 616
            + + E  +  R+ +E ER ++  +E+ + R +     +KL KE+E+E       E+    
Sbjct: 2085 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2144

Query: 617  DGRKKEAEIIKQLKIE----LKKAQESQKEMKLLLDMYRSAPKE-------QRDKVQLMA 665
              +  +AE+ K  K       +KAQ  Q+   L L +  +  ++       QR K +   
Sbjct: 2145 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2204

Query: 666  AEKKSKAELEDL------RQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQK--- 716
            A ++     E+L       + L  L+ + + EN+ +   D     R ++E+ E +++   
Sbjct: 2205 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2264

Query: 717  ---KLAMAKQEEEAL--LSEMDVTGQ--AFEDMQEQNIRLMQQ-LREKDDANFKLMSERI 768
               +L++A QE   L  L+E D+  Q    E M ++ ++ +Q+  R K +A      + +
Sbjct: 2265 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2324

Query: 769  KSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQ 828
               Q  + L+E+KE++A Q+         + Q  ++  E E   Q  +    + L LR  
Sbjct: 2325 AQEQARR-LQEDKEQMAQQLA-------EETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2376

Query: 829  ALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVEN-------SVTKEKDMFNFKR 881
             +   + +A E AQ     + Q E   +KLH  +    E         + +++   + +R
Sbjct: 2377 EMSRAQARAEEDAQ---RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2433

Query: 882  AQEDISRLRRKLE 894
             +E I+ L R+ E
Sbjct: 2434 LREAIAELEREKE 2446



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 166/835 (19%), Positives = 338/835 (40%), Gaps = 150/835 (17%)

Query: 124  RKALVVPEPEPDSDSNQER-KDDRERGEGQEPAFSFLATLASSSSEEMESQLQER----- 177
            ++A  VP   P+ ++ +   K  R + E Q+P F  L       ++E+  +LQ+R     
Sbjct: 1099 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD-ELRGAQEVGERLQQRHGERD 1157

Query: 178  --VESSRRAVSQIVTVYDKLQEKVELLSRKLNS-GDNL-IVEEAVQELNSFLAQENMRLQ 233
              VE  R  V+Q++  +  +  + ++  R+L   G  L    E+   L ++L     R +
Sbjct: 1158 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1217

Query: 234  ELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLA 293
            ++  +     + + ++  + Q+ +E  E     +E      +  I+ I+  E +L  + A
Sbjct: 1218 QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1277

Query: 294  EVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDF 353
            + LE V S   K      S                           ++ + E   LR  +
Sbjct: 1278 Q-LEPVASPAKKPKVQSGS---------------------------ESVIQEYVDLRTHY 1309

Query: 354  EEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTR 413
             E+TT   +    ++   E + +   E R  + Q +       +++A L++ R L     
Sbjct: 1310 SELTTLTSQY---IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-- 1364

Query: 414  GTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPIN 473
              H       ER+   L ++++ EV++ E+     +++   ++ E +Q   ++E    I 
Sbjct: 1365 --HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE--AEIQ 1420

Query: 474  REMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEP 533
             + R   ++ ++         LR + ++R  +  L  T  + G A               
Sbjct: 1421 AKARQAEAAERSR--------LRIEEEIRVVRLQLEATERQRGGA--------------- 1457

Query: 534  AELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERERERERE-------- 585
                        +  A +A  E+A E + ++ +EE ER RR+ + E +R+R+        
Sbjct: 1458 ----------EGELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1506

Query: 586  --KEKEREREKQK-LKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQES--- 639
               E E  REKQ+ L+  E+ R  A++ E+      R+ E E  +Q+++ L+ AQ S   
Sbjct: 1507 VKAEAEAAREKQRALQALEELRLQAEEAERRL----RQAEVERARQVQVALETAQRSAEA 1562

Query: 640  --------------------QKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAEL----- 674
                                Q+E   +  +   A +  + + +   A ++++ EL     
Sbjct: 1563 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1622

Query: 675  ---EDLRQRL--------KDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQ 723
               E LR RL        K L   E ++ K+ A+ +A R+ +A E+ +   Q++LA  + 
Sbjct: 1623 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR--QRELAEQEL 1680

Query: 724  EEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEE 783
            E++  L+E   T Q     +++ IRL  +  + +     L  E  +  +      ++++E
Sbjct: 1681 EKQRQLAE--GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1738

Query: 784  LADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQL 843
            L  ++  ++ +++  L    + EE+         T EK      Q LE    +  E A+ 
Sbjct: 1739 LEAELAKVRAEMEVLLASKARAEEESR------STSEKS----KQRLEAEAGRFRELAEE 1788

Query: 844  ADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKK 898
            A  L+A  E A+++    +++        E+ +     A  + +RL+ + E   K
Sbjct: 1789 AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1843



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 183/903 (20%), Positives = 380/903 (42%), Gaps = 127/903 (14%)

Query: 20   EKKAAVEDSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKL 79
            EK AA    G     ++LG + S  E    TL++K +   E   QRQ   +E R   E  
Sbjct: 1921 EKAAA----GKAELELELGRIRSNAE---DTLRSKEQAELEAARQRQLAAEEERRRREAE 1973

Query: 80   ERRQAT----------DDASLLIVNRYWSQFDENIRI-------ILKRYDLEQGLGD--L 120
            ER Q +            A+L  V R  ++ +E  R+         ++  L Q      L
Sbjct: 1974 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2033

Query: 121  LTERKA--LVVPEPEPDSDSNQERKD---DRERGEGQEPAFSFLATLASSSSEEMESQLQ 175
              E KA    V + E +     +++    D+ RGE +       A  A+  +EE   Q +
Sbjct: 2034 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA------ARRAAEEAEEARVQAE 2087

Query: 176  ERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQEL--NSFLAQENMRLQ 233
                 SRR V +   +    +E+ +  ++   + + L  +EA QE    +   Q  +R +
Sbjct: 2088 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR-KEAEQEAARRAQAEQAALRQK 2146

Query: 234  ELTDLLQEKHRTMS-----------QEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIR 282
            +  D   EKH+  +           QE + L+ ++E  + + ++L+  +  L+ +  +  
Sbjct: 2147 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2206

Query: 283  KREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITI----NARKFEEMNAELEENKEL 338
            ++  ++   L  V  RV  +      A        + +    N ++F  +  E E+ K++
Sbjct: 2207 RQRSQVEEELFSV--RVQMEELSKLKARIEAENRALILRDKDNTQRF--LQEEAEKMKQV 2262

Query: 339  AQN--RLC----ELEKLRQDFEEVTTQN----EKLKVELRSAVEQVVKETPEYRCMQSQF 388
            A+   RL     E  +LRQ  EE   Q     EK+  E   AV++  +   E   +Q Q 
Sbjct: 2263 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2322

Query: 389  SVLYNESLQLKAHLDE-ARTLLHGTRGTHQHQVELIERDEVSLH---KKLRTEVIQLEDT 444
             +   ++ +L+   ++ A+ L   T+G  Q  +E   + ++ +    ++L+  V ++   
Sbjct: 2323 ELAQEQARRLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2381

Query: 445  LAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREA 504
             A+  ++ +  R + E+      +     +E   L+ +L+    Q   +  R +  + E 
Sbjct: 2382 QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2441

Query: 505  QSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKAS---------QE 555
            + +  K +L+  + LLQ +S  E    +  +L  +++ L     + K S         QE
Sbjct: 2442 ERE--KEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2498

Query: 556  DANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKH 615
             A   +  +DE  + ++ RE+++ ++++ E  +ER+R    ++E+ + +  A++  + K 
Sbjct: 2499 KAKLEQLFQDEVAKAQQLREEQQRQQQQME--QERQRLVASMEEARRRQHEAEEGVRRKQ 2556

Query: 616  DDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQ-----------------R 658
            ++ ++ E +  +Q ++  ++ Q  +++++LL + +R+A                     R
Sbjct: 2557 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR 2616

Query: 659  DKVQLMAAEKKSKAELEDLR-----QRLKDLEDKEKKENKKMAD-EDALRKIRAVEEQIE 712
            D +   AAE + +   + LR     QRL++      +E +++A     + ++   E+   
Sbjct: 2617 DALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRH 2676

Query: 713  YLQKKLAMAKQEEEALLSEMDV------------TGQAFEDMQEQNIRLMQQLREKDDAN 760
            YLQ + ++A    +A   ++ V            T     + Q  +  L+  +R +    
Sbjct: 2677 YLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTV 2736

Query: 761  FKLMSERIKSNQI-HKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEH---LLQSNI 816
             + + E +   ++ HKLL  E+     +      Q+     + + L  +EH   LL++ I
Sbjct: 2737 NEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQI 2796

Query: 817  GTG 819
             TG
Sbjct: 2797 ATG 2799


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  125 bits (313), Expect = 3e-28
 Identities = 210/1004 (20%), Positives = 407/1004 (40%), Gaps = 164/1004 (16%)

Query: 55   NRKLAEMLDQRQAIEDELREHIEKLERRQ--------ATDDASLLIVNRYWSQFDE---- 102
            ++ + E L Q QA+ +E+  H EK+E  Q        A  D  L +V  Y +Q +     
Sbjct: 1268 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVT-YKAQLEPVASP 1326

Query: 103  ---------NIRIILKRYDLEQGLGDL--LTERKALVVPE-----PEPDSDSNQERKDDR 146
                     +  +I +  DL     +L  LT +    + E      E +  + Q+R ++R
Sbjct: 1327 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1386

Query: 147  ERGEGQEPAFSFLATLASS----------SSEEMESQLQERVESSRRAVSQIVTVYDKLQ 196
            ER    E A      LA +           ++E++ ++QE V     A          +Q
Sbjct: 1387 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1446

Query: 197  EKVELLSRKLNSGDNLIVEEA-VQELNSFLAQENMRLQELTDLLQEKHRTMSQ-EFSKLQ 254
            E+++ L +   +       +A   E +    +E +R+  L     E+ R  ++ E   L+
Sbjct: 1447 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1506

Query: 255  SKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLY 314
            ++ E AE++    +   + L+  +    +R+++    LA  ++       +   A  +L 
Sbjct: 1507 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1566

Query: 315  GGTITINARKFEEMNAELEENKEL-------AQNRLCELEKLRQDFEEVTTQNEKLKVEL 367
               +     +     AE+E  +++        ++   EL+  R  F E T Q E+   E 
Sbjct: 1567 ELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE 1626

Query: 368  RSAVEQVVKETPEYRCMQ---------------SQFSVLYNESLQLKAHLDEARTLLHGT 412
              AV Q ++E  E R  Q                ++ +  NE+L+L+   +E        
Sbjct: 1627 HVAVAQ-LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1685

Query: 413  RGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPI 472
            +   + Q E  ER+     K     V Q E    ++ K+ ++     +Q LAA ++   +
Sbjct: 1686 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1745

Query: 473  NREM---RHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDP 529
              E          L+    +L+ E     +K +E +++L K R      LL S++  E+ 
Sbjct: 1746 RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-EVLLASKARAEEE 1804

Query: 530  KDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERERER------- 582
                +E     + L +++   +   E+A  +++  +E +R+R+  E++  R+R       
Sbjct: 1805 SRSTSE--KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1862

Query: 583  ----------------------EREKEKERERE-----------------------KQKL 597
                                  E+E E ER R                        +++L
Sbjct: 1863 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1922

Query: 598  KESEKERDSAKDKEKGKHDD---GRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAP 654
             +  K  DS  +++KG  +D    R++  E I  LK   +KA   + E++L L   RS  
Sbjct: 1923 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1982

Query: 655  KE---QRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQI 711
            ++    +++ +L AA ++  A  E+ R+R    E +E+ +    A+E+A R+ +A  E++
Sbjct: 1983 EDTLRSKEQAELEAARQRQLAAEEERRRR----EAEERVQKSLAAEEEAARQRKAALEEV 2038

Query: 712  EYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSN 771
            E L+ K+  A++  E    E     Q  ++  ++ +    Q  EK  A     + + K  
Sbjct: 2039 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL----QAEEKAHA----FAVQQKEQ 2090

Query: 772  QIHKLLKEEKEEL-------------ADQVLTLKTQVDAQ-LQVVRKLEEKEHLLQSNIG 817
            ++ + L++E+  L             A++    + Q + +  Q  R++EE E L QS   
Sbjct: 2091 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2150

Query: 818  TGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMF 877
              +     +  A ++ K    EAA+ A     Q  L QK+  D   E+ ++    E+ + 
Sbjct: 2151 QAQARAQAQAAAEKLRKEAEQEAARRAQ--AEQAALRQKQAAD--AEMEKHKKFAEQTLR 2206

Query: 878  NFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDYKARLT 921
               + +++++ LR +LE T    N      +L EE++  KA  T
Sbjct: 2207 QKAQVEQELTTLRLQLEETDHQKN------LLDEELQRLKAEAT 2244



 Score =  102 bits (255), Expect = 1e-21
 Identities = 200/973 (20%), Positives = 390/973 (40%), Gaps = 157/973 (16%)

Query: 36   KLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNR 95
            K   + + EEL ++  + + R        RQA  +  R+    LE  Q + +A L     
Sbjct: 1558 KQRALQALEELRLQAEEAERRL-------RQAEVERARQVQVALETAQRSAEAELQSKRA 1610

Query: 96   YWSQFDENIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPA 155
             +++         K   LE+ L +   E  A+     E +  + Q+ + +R R E +   
Sbjct: 1611 SFAE---------KTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAERE- 1657

Query: 156  FSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVE 215
               L      ++E +  +LQ    + +++++Q     +K +E+ E  +R+    +    E
Sbjct: 1658 ---LERWQLKANEALRLRLQAEEVAQQKSLAQAEA--EKQKEEAEREARRRGKAE----E 1708

Query: 216  EAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQ 275
            +AV++      QE  + ++L +   ++     QE  +L+++ E  E +  +LE  +  LQ
Sbjct: 1709 QAVRQ-RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1767

Query: 276  WDIDKIRKREQRLNRHLA------EVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMN 329
             +     ++ Q L   LA      EVL    ++  +   + S      +   A +F E+ 
Sbjct: 1768 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1827

Query: 330  AELEENKELA-----QNRLCELEKLRQDFEEVTTQNEKL---------KVELRSAVEQVV 375
             E    + LA     Q +L E +  RQ  E      EKL         K E   A+++  
Sbjct: 1828 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1887

Query: 376  KETPEYRCMQS----QFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLH 431
             E    R +      Q   L  ++ Q KA ++E    L     +   + + +  D +   
Sbjct: 1888 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1947

Query: 432  KKLRTEVIQLEDTL-------AQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQ 484
            +++  E++ L+ +        A++  E   +R   E TL + EQA       R L +  +
Sbjct: 1948 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2007

Query: 485  NHNHQLKG---------------------EVLRYKRKLREAQSDLNKTRLRSGSALLQSQ 523
                + +                      EV R K K+ EA+    +    S   L  +Q
Sbjct: 2008 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2067

Query: 524  SSTEDPKDEPAELKPDS---------------------EDLSSQSSASKASQEDANEIKS 562
             + +  K   AE K  +                     + L  ++ A++ + E+A E + 
Sbjct: 2068 EAAQ--KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2125

Query: 563  KRDEEERERERREKEREREREREKEKEREREK-----QKL-KESEKERDSAKDKEKGKHD 616
            + + E  +  R+ +E ER ++  +E+ + R +     +KL KE+E+E       E+    
Sbjct: 2126 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2185

Query: 617  DGRKKEAEIIKQLKIE----LKKAQESQKEMKLLLDMYRSAPKE-------QRDKVQLMA 665
              +  +AE+ K  K       +KAQ  Q+   L L +  +  ++       QR K +   
Sbjct: 2186 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2245

Query: 666  AEKKSKAELEDL------RQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQK--- 716
            A ++     E+L       + L  L+ + + EN+ +   D     R ++E+ E +++   
Sbjct: 2246 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2305

Query: 717  ---KLAMAKQEEEAL--LSEMDVTGQ--AFEDMQEQNIRLMQQ-LREKDDANFKLMSERI 768
               +L++A QE   L  L+E D+  Q    E M ++ ++ +Q+  R K +A      + +
Sbjct: 2306 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2365

Query: 769  KSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQ 828
               Q  + L+E+KE++A Q+         + Q  ++  E E   Q  +    + L LR  
Sbjct: 2366 AQEQARR-LQEDKEQMAQQLA-------EETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2417

Query: 829  ALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVEN-------SVTKEKDMFNFKR 881
             +   + +A E AQ     + Q E   +KLH  +    E         + +++   + +R
Sbjct: 2418 EMSRAQARAEEDAQ---RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2474

Query: 882  AQEDISRLRRKLE 894
             +E I+ L R+ E
Sbjct: 2475 LREAIAELEREKE 2487



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 166/835 (19%), Positives = 338/835 (40%), Gaps = 150/835 (17%)

Query: 124  RKALVVPEPEPDSDSNQER-KDDRERGEGQEPAFSFLATLASSSSEEMESQLQER----- 177
            ++A  VP   P+ ++ +   K  R + E Q+P F  L       ++E+  +LQ+R     
Sbjct: 1140 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD-ELRGAQEVGERLQQRHGERD 1198

Query: 178  --VESSRRAVSQIVTVYDKLQEKVELLSRKLNS-GDNL-IVEEAVQELNSFLAQENMRLQ 233
              VE  R  V+Q++  +  +  + ++  R+L   G  L    E+   L ++L     R +
Sbjct: 1199 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1258

Query: 234  ELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLA 293
            ++  +     + + ++  + Q+ +E  E     +E      +  I+ I+  E +L  + A
Sbjct: 1259 QIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKA 1318

Query: 294  EVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDF 353
            + LE V S   K      S                           ++ + E   LR  +
Sbjct: 1319 Q-LEPVASPAKKPKVQSGS---------------------------ESVIQEYVDLRTHY 1350

Query: 354  EEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTR 413
             E+TT   +    ++   E + +   E R  + Q +       +++A L++ R L     
Sbjct: 1351 SELTTLTSQY---IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-- 1405

Query: 414  GTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPIN 473
              H       ER+   L ++++ EV++ E+     +++   ++ E +Q   ++E    I 
Sbjct: 1406 --HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE--AEIQ 1461

Query: 474  REMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEP 533
             + R   ++ ++         LR + ++R  +  L  T  + G A               
Sbjct: 1462 AKARQAEAAERSR--------LRIEEEIRVVRLQLEATERQRGGA--------------- 1498

Query: 534  AELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERERERERE-------- 585
                        +  A +A  E+A E + ++ +EE ER RR+ + E +R+R+        
Sbjct: 1499 ----------EGELQALRARAEEA-EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1547

Query: 586  --KEKEREREKQK-LKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQES--- 639
               E E  REKQ+ L+  E+ R  A++ E+      R+ E E  +Q+++ L+ AQ S   
Sbjct: 1548 VKAEAEAAREKQRALQALEELRLQAEEAERRL----RQAEVERARQVQVALETAQRSAEA 1603

Query: 640  --------------------QKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAEL----- 674
                                Q+E   +  +   A +  + + +   A ++++ EL     
Sbjct: 1604 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1663

Query: 675  ---EDLRQRL--------KDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQ 723
               E LR RL        K L   E ++ K+ A+ +A R+ +A E+ +   Q++LA  + 
Sbjct: 1664 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVR--QRELAEQEL 1721

Query: 724  EEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEE 783
            E++  L+E   T Q     +++ IRL  +  + +     L  E  +  +      ++++E
Sbjct: 1722 EKQRQLAE--GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1779

Query: 784  LADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQL 843
            L  ++  ++ +++  L    + EE+         T EK      Q LE    +  E A+ 
Sbjct: 1780 LEAELAKVRAEMEVLLASKARAEEESR------STSEKS----KQRLEAEAGRFRELAEE 1829

Query: 844  ADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKK 898
            A  L+A  E A+++    +++        E+ +     A  + +RL+ + E   K
Sbjct: 1830 AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1884



 Score = 90.1 bits (222), Expect = 9e-18
 Identities = 183/903 (20%), Positives = 380/903 (42%), Gaps = 127/903 (14%)

Query: 20   EKKAAVEDSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKL 79
            EK AA    G     ++LG + S  E    TL++K +   E   QRQ   +E R   E  
Sbjct: 1962 EKAAA----GKAELELELGRIRSNAE---DTLRSKEQAELEAARQRQLAAEEERRRREAE 2014

Query: 80   ERRQAT----------DDASLLIVNRYWSQFDENIRI-------ILKRYDLEQGLGD--L 120
            ER Q +            A+L  V R  ++ +E  R+         ++  L Q      L
Sbjct: 2015 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2074

Query: 121  LTERKA--LVVPEPEPDSDSNQERKD---DRERGEGQEPAFSFLATLASSSSEEMESQLQ 175
              E KA    V + E +     +++    D+ RGE +       A  A+  +EE   Q +
Sbjct: 2075 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA------ARRAAEEAEEARVQAE 2128

Query: 176  ERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQEL--NSFLAQENMRLQ 233
                 SRR V +   +    +E+ +  ++   + + L  +EA QE    +   Q  +R +
Sbjct: 2129 REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR-KEAEQEAARRAQAEQAALRQK 2187

Query: 234  ELTDLLQEKHRTMS-----------QEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIR 282
            +  D   EKH+  +           QE + L+ ++E  + + ++L+  +  L+ +  +  
Sbjct: 2188 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2247

Query: 283  KREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITI----NARKFEEMNAELEENKEL 338
            ++  ++   L  V  RV  +      A        + +    N ++F  +  E E+ K++
Sbjct: 2248 RQRSQVEEELFSV--RVQMEELSKLKARIEAENRALILRDKDNTQRF--LQEEAEKMKQV 2303

Query: 339  AQN--RLC----ELEKLRQDFEEVTTQN----EKLKVELRSAVEQVVKETPEYRCMQSQF 388
            A+   RL     E  +LRQ  EE   Q     EK+  E   AV++  +   E   +Q Q 
Sbjct: 2304 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2363

Query: 389  SVLYNESLQLKAHLDE-ARTLLHGTRGTHQHQVELIERDEVSLH---KKLRTEVIQLEDT 444
             +   ++ +L+   ++ A+ L   T+G  Q  +E   + ++ +    ++L+  V ++   
Sbjct: 2364 ELAQEQARRLQEDKEQMAQQLAEETQG-FQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2422

Query: 445  LAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREA 504
             A+  ++ +  R + E+      +     +E   L+ +L+    Q   +  R +  + E 
Sbjct: 2423 QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2482

Query: 505  QSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKAS---------QE 555
            + +  K +L+  + LLQ +S  E    +  +L  +++ L     + K S         QE
Sbjct: 2483 ERE--KEKLQQEAKLLQLKSE-EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2539

Query: 556  DANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKH 615
             A   +  +DE  + ++ RE+++ ++++ E  +ER+R    ++E+ + +  A++  + K 
Sbjct: 2540 KAKLEQLFQDEVAKAQQLREEQQRQQQQME--QERQRLVASMEEARRRQHEAEEGVRRKQ 2597

Query: 616  DDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQ-----------------R 658
            ++ ++ E +  +Q ++  ++ Q  +++++LL + +R+A                     R
Sbjct: 2598 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR 2657

Query: 659  DKVQLMAAEKKSKAELEDLR-----QRLKDLEDKEKKENKKMAD-EDALRKIRAVEEQIE 712
            D +   AAE + +   + LR     QRL++      +E +++A     + ++   E+   
Sbjct: 2658 DALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRH 2717

Query: 713  YLQKKLAMAKQEEEALLSEMDV------------TGQAFEDMQEQNIRLMQQLREKDDAN 760
            YLQ + ++A    +A   ++ V            T     + Q  +  L+  +R +    
Sbjct: 2718 YLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTV 2777

Query: 761  FKLMSERIKSNQI-HKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEH---LLQSNI 816
             + + E +   ++ HKLL  E+     +      Q+     + + L  +EH   LL++ I
Sbjct: 2778 NEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQI 2837

Query: 817  GTG 819
             TG
Sbjct: 2838 ATG 2840


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score =  123 bits (309), Expect = 7e-28
 Identities = 190/907 (20%), Positives = 384/907 (42%), Gaps = 142/907 (15%)

Query: 51   LQTKNRKLAEMLDQRQAIEDELREHIEKLER-----RQATDDASLLI--VNRYWSQFDEN 103
            L+ K +++ E  +  + I  EL     KLE      ++  DD  L +  V +     +  
Sbjct: 919  LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 978

Query: 104  IRIILKRY-DLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATL 162
            ++ + +    L++ +  L  E+KAL         +++Q+  DD +  E +        T 
Sbjct: 979  VKNLTEEMAGLDETIAKLTKEKKAL--------QEAHQQTLDDLQAEEDKVNTL----TK 1026

Query: 163  ASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELN 222
            A    E+    L+  +E  ++    +     KL+  +     KL     + +E   Q+L+
Sbjct: 1027 AKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDL-----KLAQESTMDIENDKQQLD 1081

Query: 223  SFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIR 282
              L ++   +  L   ++++     Q    LQ K++  ++R+  LE  I+  +    K  
Sbjct: 1082 EKLKKKEFEMSGLQSKIEDEQALGMQ----LQKKIKELQARIEELEEEIEAERASRAKAE 1137

Query: 283  KREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNR 342
            K+   L+R L E+ ER+   G           G T           +A++E NK+    R
Sbjct: 1138 KQRSDLSRELEEISERLEEAG-----------GAT-----------SAQIEMNKK----R 1171

Query: 343  LCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPE-YRCMQSQFSVLYNESLQLKAH 401
              E +K+R+D EE T Q+E     LR      V E  E    +Q     L  E  ++K  
Sbjct: 1172 EAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKME 1231

Query: 402  LDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVR-KEYEMLRIEFE 460
            +D+  +            +E + + + +L K  R     LED L++++ KE E  R+  +
Sbjct: 1232 IDDLAS-----------NMETVSKAKGNLEKMCRA----LEDQLSEIKTKEEEQQRLIND 1276

Query: 461  ---QTLAANEQAGPINREMRH---LISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLR 514
               Q      ++G  +R++     L+S L         ++   KR+L E         ++
Sbjct: 1277 LTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEE--------EIK 1328

Query: 515  SGSALLQS-QSSTED------PKDEPAELKPDSEDLSSQSSASKASQEDANEIKS-KRDE 566
            + SAL  + QSS  D        +E  E K + +   S++++  A      E  + +R E
Sbjct: 1329 AKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTE 1388

Query: 567  EERERERREKEREREREREKE------KEREREKQKLKES------EKERDSAK----DK 610
            E  E +++  +R ++ E   E         E+ KQ+L+        + ER +A     DK
Sbjct: 1389 ELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDK 1448

Query: 611  EKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKS 670
            ++   D    +  +  ++   EL+ +Q+  + +   L   ++A +E  D+++ +  E K+
Sbjct: 1449 KQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKN 1508

Query: 671  -KAELEDLRQ-------RLKDLED-----KEKKENKKMADEDALRKIRAVEEQIEYLQKK 717
             + E+ DL +       R+ +LE      +++K   + A E+A   +   E +I  +Q +
Sbjct: 1509 LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLE 1568

Query: 718  LAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLL 777
            L   K E +  ++E D   +  + M+  +IR+++ ++   DA  +  ++ I      +L 
Sbjct: 1569 LNQVKSEVDRKIAEKD---EEIDQMKRNHIRIVESMQSTLDAEIRSRNDAI------RLK 1619

Query: 778  KEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLL---QSNIGTGEKELGLRTQALEMNK 834
            K+ + +L +  + L        + +R     + +L   Q ++    +      + L M +
Sbjct: 1620 KKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVE 1679

Query: 835  RKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSV------TKEKDMFNFKRAQE-DIS 887
            R+A       ++L+A LE  ++     + E+++ S       T+   + N K+  E DIS
Sbjct: 1680 RRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDIS 1739

Query: 888  RLRRKLE 894
            +++ ++E
Sbjct: 1740 QIQGEME 1746



 Score =  105 bits (263), Expect = 2e-22
 Identities = 160/790 (20%), Positives = 346/790 (43%), Gaps = 104/790 (13%)

Query: 57   KLAEMLDQRQAIEDELREHIEKLERRQATDD--ASLLIVNRYWSQFDENIRII------- 107
            +L E +D  Q ++ +L +  EK E +   DD  +++  V++     ++  R +       
Sbjct: 1206 ELGEQIDNLQRVKQKLEK--EKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEI 1263

Query: 108  -LKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSS 166
              K  + ++ + DL  +R  L     E     +++     +   G++     +  L    
Sbjct: 1264 KTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQL 1323

Query: 167  SEEME--SQLQERVESSRRAVSQIVTVYDKLQE-KVELLSRKLNSGDNLIVEEAVQELNS 223
             EE++  S L   ++SSR     +   Y++ QE K EL             + A+ + NS
Sbjct: 1324 EEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAEL-------------QRAMSKANS 1370

Query: 224  FLAQENMRLQ----ELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDID 279
             +AQ   + +    + T+ L+E  + ++Q     +  VE   ++ + LE     LQ +++
Sbjct: 1371 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVE 1430

Query: 280  KIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELA 339
             +    +R N   A  L++      K+                +K EE +AELE +++ +
Sbjct: 1431 DLMIDVERTNAACA-ALDKKQRNFDKILAEWK-----------QKCEETHAELEASQKES 1478

Query: 340  QNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLK 399
            ++   EL K++  +EE   Q E LK E ++  +++   T +      +   L     Q++
Sbjct: 1479 RSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVE 1538

Query: 400  AHLDEARTLLHGTRGTHQHQVELIERDEVSLHK---KLRTEVIQLEDTLAQVRKEY---- 452
                E +  L     + +H+   I R ++ L++   ++  ++ + ++ + Q+++ +    
Sbjct: 1539 QEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIV 1598

Query: 453  EMLRIEFEQTLAANEQAGPINREMRHLISSLQ---NHNHQLKGEVLRYKRKLREAQSDLN 509
            E ++   +  + +   A  + ++M   ++ ++   NH +++  E LR     R  Q+ L 
Sbjct: 1599 ESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALR---NYRNTQAILK 1655

Query: 510  KTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEER 569
             T+L    AL     S ED K++ A ++  +  L ++    +A+ E            + 
Sbjct: 1656 DTQLHLDDAL----RSQEDLKEQLAMVERRANLLQAEIEELRATLE------------QT 1699

Query: 570  ERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQL 629
            ER R+  E+E     E+ +    +   L  ++K+ ++   + +G+ +D       II++ 
Sbjct: 1700 ERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMED-------IIQEA 1752

Query: 630  KIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEK 689
            +   +KA+++  +  ++ +  +   KEQ     L   +K  +  ++DL+ RL + E    
Sbjct: 1753 RNAEEKAKKAITDAAMMAEELK---KEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAL 1809

Query: 690  KENKKMADEDALRKIRAVEEQIEYLQKKLAMA---KQEEEALLSEMDVTGQAFEDMQEQN 746
            K  KK   +   R +R +E ++E  QK+   A    ++ E  + E+  T Q  ED   +N
Sbjct: 1810 KGGKKQIQKLEAR-VRELEGEVESEQKRNVEAVKGLRKHERKVKEL--TYQTEED--RKN 1864

Query: 747  IRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLE 806
            I  +Q L +K       +  ++KS   +K   EE EE ++  L+   ++  +L+   + E
Sbjct: 1865 ILRLQDLVDK-------LQAKVKS---YKRQAEEAEEQSNVNLSKFRRIQHELE---EAE 1911

Query: 807  EKEHLLQSNI 816
            E+  + +S +
Sbjct: 1912 ERADIAESQV 1921



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 110/485 (22%), Positives = 210/485 (43%), Gaps = 43/485 (8%)

Query: 446  AQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQ 505
            A+  KE   ++ EFE+T     +     +E+   + +L    + L+ +V      L +A+
Sbjct: 847  AETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAE 906

Query: 506  S---DLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKS 562
                 L KT+++  + + +     ED ++  AEL      L  + S  K   +D     +
Sbjct: 907  ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 966

Query: 563  KRDEEERERERREKERERER----------EREKEKEREREKQKLKESEKERDSAKDKEK 612
            K ++E+   E + K    E            +EK+  +E  +Q L + + E D      K
Sbjct: 967  KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1026

Query: 613  GK-----HDDGRKKEAEIIKQLKIELKKAQES-QKEMKLLLDMYRSAPKEQRDKVQLMAA 666
             K       D  +   E  K+++++L++A+   + ++KL  +   S    + DK QL   
Sbjct: 1027 AKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQE---STMDIENDKQQLDEK 1083

Query: 667  EKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEE 726
             KK + E+  L+ +++D +    +  KK+ +  A  +I  +EE+IE  +   A A+++  
Sbjct: 1084 LKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQA--RIEELEEEIEAERASRAKAEKQRS 1141

Query: 727  ALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIK--SNQIHKLLKEEKEEL 784
             L  E++   +  E+        + ++ +K +A F+ M   ++  + Q        +++ 
Sbjct: 1142 DLSRELEEISERLEEAGGATSAQI-EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKH 1200

Query: 785  ADQVLTLKTQVDAQLQVVRKLE-EKEHL------LQSNIGTGEKELG--------LRTQA 829
            AD V  L  Q+D   +V +KLE EK  +      L SN+ T  K  G        L  Q 
Sbjct: 1201 ADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQL 1260

Query: 830  LEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRL 889
             E+ K K  E  +L +DL AQ    Q +  ++  ++ E      +     +   + I  L
Sbjct: 1261 SEI-KTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEEL 1319

Query: 890  RRKLE 894
            +R+LE
Sbjct: 1320 KRQLE 1324



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 87/493 (17%), Positives = 204/493 (41%), Gaps = 76/493 (15%)

Query: 168  EEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQ 227
            EE  ++L+   + SR   +++  + +  +E ++ L        NL  ++ + +L   +A+
Sbjct: 1465 EETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNL--QQEISDLTEQIAE 1522

Query: 228  ENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQR 287
               R+ EL  + ++    + QE S+LQ+ +E AE+ +   E  I  +Q ++++++     
Sbjct: 1523 GGKRIHELEKIKKQ----VEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSE--- 1575

Query: 288  LNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELE 347
            ++R +AE  E ++                    + R  E M + L+       + +   +
Sbjct: 1576 VDRKIAEKDEEIDQMKRN---------------HIRIVESMQSTLDAEIRSRNDAIRLKK 1620

Query: 348  KLRQDFEEVTTQ----NEKLKVELRSA--VEQVVKETPEY--------RCMQSQFSVLYN 393
            K+  D  E+  Q    N      LR+    + ++K+T  +          ++ Q +++  
Sbjct: 1621 KMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVER 1680

Query: 394  ESLQLKAHLDEARTLLHGTRGTHQ----------HQVELIERDEVSL---HKKLRTEVIQ 440
             +  L+A ++E R  L  T  + +           +V+L+     SL    KKL T++ Q
Sbjct: 1681 RANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQ 1740

Query: 441  L----EDTLAQVRKEYEMLR-------IEFEQTLAANEQAGPINREMRHLISSLQNHNHQ 489
            +    ED + + R   E  +       +  E+     + +  + R  ++L  ++++  H+
Sbjct: 1741 IQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHR 1800

Query: 490  L-----------KGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKP 538
            L           K ++ + + ++RE + ++   + R+  A+   +      K+   + + 
Sbjct: 1801 LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEE 1860

Query: 539  DSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLK 598
            D +++          Q    ++KS + + E   E+      + R  + E E   E+  + 
Sbjct: 1861 DRKNILRLQDLVDKLQA---KVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIA 1917

Query: 599  ESEKERDSAKDKE 611
            ES+  +   K +E
Sbjct: 1918 ESQVNKLRVKSRE 1930



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 81/349 (23%), Positives = 158/349 (45%), Gaps = 58/349 (16%)

Query: 560  IKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHD--- 616
            +KS   E+E    + E E+ +E   + E +R+  ++K+    +E++  + + + + D   
Sbjct: 844  LKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLA 903

Query: 617  DGRKKEAEIIK---QLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAE 673
            D  ++  ++IK   QL+ ++K+  E              A  E+    +L A ++K + E
Sbjct: 904  DAEERCDQLIKTKIQLEAKIKEVTE-------------RAEDEEEINAELTAKKRKLEDE 950

Query: 674  LEDLRQRLKDLE-DKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEM 732
              +L++ + DLE    K E +K A E+   K++ + E++  L + +A   +E++AL    
Sbjct: 951  CSELKKDIDDLELTLAKVEKEKHATEN---KVKNLTEEMAGLDETIAKLTKEKKAL---- 1003

Query: 733  DVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQ----IHKLLKEEKEELADQV 788
                      QE + + +  L+ ++D    L   +IK  Q    +   L++EK       
Sbjct: 1004 ----------QEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEK------- 1046

Query: 789  LTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLK 848
               K ++D + +  RKLE    L Q +    E +   + Q  E  K+K  E + L   ++
Sbjct: 1047 ---KIRMDLE-RAKRKLEGDLKLAQESTMDIEND---KQQLDEKLKKKEFEMSGLQSKIE 1099

Query: 849  AQLELA---QKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLE 894
             +  L    QKK+ + Q  I E     E +  +  +A++  S L R+LE
Sbjct: 1100 DEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELE 1148



 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 68/300 (22%), Positives = 131/300 (43%), Gaps = 25/300 (8%)

Query: 633  LKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKEN 692
            L K+ E++KEM  + + +    KE+  K +  A  K+ + ++  L Q   DL+ + + E 
Sbjct: 843  LLKSAETEKEMANMKEEFEKT-KEELAKTE--AKRKELEEKMVTLMQEKNDLQLQVQAEA 899

Query: 693  KKMAD-EDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQ 751
              +AD E+   ++   + Q+E   K++    ++EE + +E+    +  ED         +
Sbjct: 900  DSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLED------ECSE 953

Query: 752  QLREKDDANFKLMSERIKSNQIHKLLKEEKEELA--DQVLTLKTQVDAQLQVVRKL---- 805
              ++ DD    L     + +     +K   EE+A  D+ +   T+    LQ   +     
Sbjct: 954  LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1013

Query: 806  ----EEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDF 861
                E+K + L       E+++     +LE  K+  M+  +    L+  L+LAQ+   D 
Sbjct: 1014 LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDI 1073

Query: 862  QD---EIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDYKA 918
            ++   ++ E    KE +M   +   ED   L  +L+  KK   +    E L EEI+  +A
Sbjct: 1074 ENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQ--KKIKELQARIEELEEEIEAERA 1131



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 68/304 (22%), Positives = 123/304 (40%), Gaps = 36/304 (11%)

Query: 62   LDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDENIRIILKRY-DLEQGLGDL 120
            LD     +++L+E +  +ERR     A +  +     Q + + +I  +   D  + +  L
Sbjct: 1661 LDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLL 1720

Query: 121  LTERKALVVPEPEPDSDSNQ---ERKDDRERGEGQEPAFSFLATLASSSSEEM--ESQLQ 175
             T+  +L+  + + ++D +Q   E +D  +     E       T A+  +EE+  E    
Sbjct: 1721 HTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTS 1780

Query: 176  ERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQENMRLQEL 235
              +E  ++ + Q V       ++ E L+ K        +E  V+EL   +  E  R  E 
Sbjct: 1781 AHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEA 1840

Query: 236  TDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEV 295
               L+ KH    +E +      +T E R ++L      LQ  +DK++ + +   R   E 
Sbjct: 1841 VKGLR-KHERKVKELT-----YQTEEDRKNILR-----LQDLVDKLQAKVKSYKRQAEEA 1889

Query: 296  LERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDFEE 355
             E+ N                   +N  KF  +  ELEE +E A     ++ KLR    E
Sbjct: 1890 EEQSN-------------------VNLSKFRRIQHELEEAEERADIAESQVNKLRVKSRE 1930

Query: 356  VTTQ 359
            V T+
Sbjct: 1931 VHTK 1934



 Score = 39.3 bits (90), Expect = 0.018
 Identities = 58/262 (22%), Positives = 110/262 (41%), Gaps = 35/262 (13%)

Query: 48   IRTLQTKNRKLAEMLDQR----QAIEDELREHIEKLERRQATDDASLLIVN-RYWSQFDE 102
            +R+ +    +LA M+++R    QA  +ELR  +E+ ER +   +  LL  + R      +
Sbjct: 1665 LRSQEDLKEQLA-MVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQ 1723

Query: 103  NIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATL 162
            N  +I  +  LE  +  +  E + ++      +  + +   D     E  +      A L
Sbjct: 1724 NTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1783

Query: 163  A--SSSSEEMESQLQERV-ESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEA-- 217
                 + E+    LQ R+ E+ + A+        KL+ +V  L  ++ S     VE    
Sbjct: 1784 ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKG 1843

Query: 218  -------VQELNSFLAQEN---MRLQELTDLLQEKHRTMSQE--------------FSKL 253
                   V+EL     ++    +RLQ+L D LQ K ++  ++              F ++
Sbjct: 1844 LRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRI 1903

Query: 254  QSKVETAESRVSVLESMIDDLQ 275
            Q ++E AE R  + ES ++ L+
Sbjct: 1904 QHELEEAEERADIAESQVNKLR 1925


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score =  123 bits (309), Expect = 7e-28
 Identities = 185/803 (23%), Positives = 353/803 (43%), Gaps = 95/803 (11%)

Query: 52   QTKNRKLAEMLDQRQAIEDELREHIEKLER--RQATDDASLLIVNRYWSQFDENIRIILK 109
            + K   +AE L +R+   D L++ +E LER  + + ++  L+I++   S+ +    +   
Sbjct: 2132 EKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAE----VETL 2187

Query: 110  RYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSSSEE 169
            +  +E+    L      LV    E ++ + Q ++   +  E  +   SF + L     E+
Sbjct: 2188 KTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLL--EEKEQ 2245

Query: 170  MESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQEN 229
             E Q++   E S+ AV  +     +L E V  L      GD  I++   Q L+  + +E+
Sbjct: 2246 AEIQIK---EESKTAVEMLQNQLKELNEAVAAL-----CGDQEIMKATEQSLDPPIEEEH 2297

Query: 230  MRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLN 289
                 +  L         ++   LQ +++ +E    +L+  +++L+ +++  R  ++   
Sbjct: 2298 QLRNSIEKLRARLEADEKKQLCVLQ-QLKESEHHADLLKGRVENLERELEIARTNQE--- 2353

Query: 290  RHLAEVLERVNSKG------YKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRL 343
             H A  LE  NSKG       K+ G   SL G  + +   + E+ N   E  KE  Q R+
Sbjct: 2354 -HAA--LEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKE--QERI 2408

Query: 344  CELEKLRQDFEEVTTQNEKLKVELR----SAVEQVVKETPEY------------------ 381
             ELE +   FE +  + E+ KV+++    +A+E +  +  E                   
Sbjct: 2409 SELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKE 2468

Query: 382  RCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKK------LR 435
            + + SQ   L  E  QL   LDEA+      + +    ++ +E  +  L KK      L+
Sbjct: 2469 QNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLK 2528

Query: 436  TEV---IQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKG 492
             ++    QL   L+QV  E+++ +   EQ L        +  E+   I  LQ+ N  L+ 
Sbjct: 2529 NQIQDQEQLVSKLSQVEGEHQLWK---EQNLELRN----LTVELEQKIQVLQSKNASLQD 2581

Query: 493  --EVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTE-DPKDEPAELKPDSEDLSSQSSA 549
              EVL+   K  E + +L K    S    +   ++ E + + E  E+   + +L  + S 
Sbjct: 2582 TLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSG 2641

Query: 550  SK-----ASQEDANEIKSKRDE-EERERERREKEREREREREKEKERE-REKQKLKESEK 602
             K       Q    EIKS +D+ +E   E  E ++  +   + + E+E + ++++ E + 
Sbjct: 2642 EKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQL 2701

Query: 603  ERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRD--K 660
                A+ K +    D  K+    I+  + +L   +E     KL +D+ +S+ +E  +  K
Sbjct: 2702 RLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLK 2761

Query: 661  VQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDAL--RKIRAVEEQIEYLQKKL 718
                  E+  K ++++L+       ++ KKEN++   +  L  +  + +EE+ E LQK+L
Sbjct: 2762 ATTQILEELKKTKMDNLK-----YVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKEL 2816

Query: 719  A--MAKQEEEALLSEMDV-TGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHK 775
            +   A QE++   + MD    +   +++E    L ++ +E D+   K  S  I     H+
Sbjct: 2817 SQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLIS----HE 2872

Query: 776  LLKEEKEELADQVLTLKTQVDAQ 798
             L++ KE L  QV  L +Q   Q
Sbjct: 2873 KLEKAKEMLETQVAHLCSQQSKQ 2895



 Score =  113 bits (282), Expect = 1e-24
 Identities = 182/826 (22%), Positives = 342/826 (41%), Gaps = 111/826 (13%)

Query: 57   KLAEMLDQRQAIEDELREHIEKLERR-QATDDASLLIVNRYWSQFDENIRIILKRYDLEQ 115
            + A  L   Q    +LR  IEKL  R +A +   L I  +   +  EN  +  K  +LE+
Sbjct: 2102 EFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLER 2161

Query: 116  GLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSSSEEMESQLQ 175
             L  +  E + LV+ + E      +  K   E        F        S  E +  Q+Q
Sbjct: 2162 EL-QMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQ 2220

Query: 176  ERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVE---EAVQELNSFLA-----Q 227
            E+ +     + ++++ +  L E+ E    ++       VE     ++ELN  +A     Q
Sbjct: 2221 EK-QGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQ 2279

Query: 228  ENMRL--QELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKRE 285
            E M+   Q L   ++E+H+ +     KL++++E  E +   +   + + +   D ++ R 
Sbjct: 2280 EIMKATEQSLDPPIEEEHQ-LRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRV 2338

Query: 286  QRLNRHLA--------EVLERVNSKGY------KVYGAGSSLYGGTITINARKFEEMNAE 331
            + L R L           LE  NSKG       K+ G   SL G  + +   + E+ N  
Sbjct: 2339 ENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLT 2398

Query: 332  LEENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVL 391
             E  KE  Q R+ ELE +   FE +  + E+ KV+++       K +     +Q+Q    
Sbjct: 2399 NELQKE--QERISELEIINSSFENILQEKEQEKVQMKE------KSSTAMEMLQTQLK-- 2448

Query: 392  YNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKE 451
                      L+E    LH      Q   +  E++  S  + L  E  QL   L + +  
Sbjct: 2449 ---------ELNERVAALHND----QEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNN 2495

Query: 452  YEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKG---EVLRYKRKLREAQSDL 508
            Y +L+                   +  LI  +++   +L+    E+ R K ++++ +  +
Sbjct: 2496 YIVLQ-----------------SSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLV 2538

Query: 509  NKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKS---KRD 565
            +K     G   L  + + E  ++   EL+   + L S++    AS +D  E+     K  
Sbjct: 2539 SKLSQVEGEHQLWKEQNLE-LRNLTVELEQKIQVLQSKN----ASLQDTLEVLQSSYKNL 2593

Query: 566  EEERERERREKERERERERE---KEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKE 622
            E E E  + +K    E+  +   KE E +RE  ++ +   E       EK +     +  
Sbjct: 2594 ENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLL 2653

Query: 623  AEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLK 682
             E IK  K +LK+      E+K  LD      K+Q +K      E K + E+ + + RL 
Sbjct: 2654 LEEIKSSKDQLKELTLENSELKKSLDCMH---KDQVEK------EGKVREEIAEYQLRLH 2704

Query: 683  DLEDK------EKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTG 736
            + E K      +  +  ++  +    K+ + EE +   + ++ + K  +E L + +  T 
Sbjct: 2705 EAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATT 2764

Query: 737  QAFEDMQE---QNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKT 793
            Q  E++++    N++ + QL+++++     M   IKS    K L+EEKE L  ++     
Sbjct: 2765 QILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKS---CKQLEEEKEILQKEL----- 2816

Query: 794  QVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAME 839
               +QLQ  ++ ++   ++ + +     E+    + LE   ++A E
Sbjct: 2817 ---SQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADE 2859



 Score =  112 bits (281), Expect = 1e-24
 Identities = 190/939 (20%), Positives = 395/939 (42%), Gaps = 111/939 (11%)

Query: 32   VETIKLGGVSSTEELDIRT----LQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDD 87
            +E  K+ G    E  D+          +++L + ++  + +  +L  H +K  R    D+
Sbjct: 1826 IELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDN 1885

Query: 88   ASLLIVNRYWSQFDENIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRE 147
             +   VN  W +   ++   L R   E+       E +AL +   E D +  Q  K   E
Sbjct: 1886 VAK--VNDSWKERFLDVENELSRIRSEKAS----IEHEALYL---EADLEVVQTEKLCLE 1936

Query: 148  R-GEGQEPAFSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKL 206
            +  E ++     L    S  + E  +QL+  +++    +S+  T  D+L EK++  +++L
Sbjct: 1937 KDNENKQKVIVCLEEELSVVTSE-RNQLRGELDT----MSKKTTALDQLSEKMKEKTQEL 1991

Query: 207  NSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSV 266
             S  +  +   +Q   + + ++   LQ L+  + E    + ++ + LQ K+++ E     
Sbjct: 1992 ESHQSECLH-CIQVAEAEVKEKTELLQTLSSDVSE----LLKDKTHLQEKLQSLEKDSQA 2046

Query: 267  LESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYG-----GTITIN 321
            L     +L+  I ++ K ++ L +    +  R++   Y+      +L       G   + 
Sbjct: 2047 LSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALR 2106

Query: 322  ARKFEEMNAELEENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEY 381
                +E   +L    E  + R+   EK +    E   + E+    L+  VE + +E    
Sbjct: 2107 LSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLEREL--- 2163

Query: 382  RCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQL 441
            +  +    ++  ++   KA ++  +T +          +++ E D V+L  +      Q+
Sbjct: 2164 QMSEENQELVILDAENSKAEVETLKTQIEEMA----RSLKVFELDLVTLRSEKENLTKQI 2219

Query: 442  EDTLAQVRKEYEMLRIEFEQTLAANEQAG-PINREMRHLISSLQNHNHQLKGEVLRYKRK 500
            ++   Q+  E + L   F+  L   EQA   I  E +  +  LQN   QLK        +
Sbjct: 2220 QEKQGQL-SELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQN---QLK--------E 2267

Query: 501  LREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQ----ED 556
            L EA + L   +      +  ++ S + P +E  +L+   E L ++  A +  Q    + 
Sbjct: 2268 LNEAVAALCGDQ----EIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQ 2323

Query: 557  ANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHD 616
              E +   D  +   E  E+E E  R  ++    E E  K      E ++ K K +G   
Sbjct: 2324 LKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSK-----GEVETLKAKIEGMTQ 2378

Query: 617  DGRKKEAEII------KQLKIELKKAQESQKEMKLLLDMYRSAPKE-QRDKVQLMAAEKK 669
              R  E +++      + L  EL+K QE   E++++   + +  +E +++KVQ+   ++K
Sbjct: 2379 SLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQM---KEK 2435

Query: 670  SKAELEDLRQRLKDLEDK-----EKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQE 724
            S   +E L+ +LK+L ++       +E  K  +++   ++  +E +   L + L  AK  
Sbjct: 2436 SSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNN 2495

Query: 725  E-------EALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLL 777
                      L+ E++   Q  E   E+  RL  Q+++++    +L+S+  +    H+L 
Sbjct: 2496 YIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQE----QLVSKLSQVEGEHQLW 2551

Query: 778  KEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKA 837
            KE+  EL +  + L+ ++         L++   +LQS+    E EL       E+ K   
Sbjct: 2552 KEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENEL-------ELTKMDK 2604

Query: 838  MEAAQLADDLKAQLELAQKKLHDFQDEIVE--NSVTKEKD---------MFNFKRAQEDI 886
            M   +  + + A+    Q+++H+   +  E    ++ EK+         +   K +++ +
Sbjct: 2605 MSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQL 2664

Query: 887  SRLRRKLETTKKPDNVPKCDEI-----LMEEIKDYKARL 920
              L  +    KK  +    D++     + EEI +Y+ RL
Sbjct: 2665 KELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRL 2703



 Score =  108 bits (269), Expect = 3e-23
 Identities = 174/792 (21%), Positives = 344/792 (43%), Gaps = 139/792 (17%)

Query: 133  EPDSDSNQERK-DDRERGEGQ---EPAFS---FLATLASSSSEEMESQLQERVESSRRAV 185
            E   D+N E   +D+ +G  +   E +FS    L  +    ++E    LQ RV+ +    
Sbjct: 1724 EQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNEN 1783

Query: 186  SQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQEKHRT 245
             +++ V +    KVE L  ++   D+ +  + VQ +    A   + L+++   L++++  
Sbjct: 1784 LRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEAC--IELEKIVGELKKENSD 1841

Query: 246  MSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYK 305
            +S++        +    RV   E +  DL+   DK  + +      + + + +VN     
Sbjct: 1842 LSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSRED------IGDNVAKVN----- 1890

Query: 306  VYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDFEEVTTQNEKLKV 365
                           ++ K   ++ E E ++  ++    E E L  + +    Q EKL +
Sbjct: 1891 ---------------DSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCL 1935

Query: 366  ELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIER 425
            E  +  +Q V       C++ + SV+ +E  QL+  LD   T+   T    Q   ++ E+
Sbjct: 1936 EKDNENKQKV-----IVCLEEELSVVTSERNQLRGELD---TMSKKTTALDQLSEKMKEK 1987

Query: 426  -DEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQ 484
              E+  H+      IQ+ +  A+V+++ E+L     QTL+++     + ++  HL   LQ
Sbjct: 1988 TQELESHQSECLHCIQVAE--AEVKEKTELL-----QTLSSD--VSELLKDKTHLQEKLQ 2038

Query: 485  NHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLS 544
            +     +   L  K +L    + LNK +      L++   S +      A L     +  
Sbjct: 2039 SLEKDSQALSLT-KCELENQIAQLNKEK----ELLVKESESLQ------ARLSESDYEKL 2087

Query: 545  SQSSASKASQEDANE--IKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEK 602
            + S A +A+  +  E  ++    +EE  + RR  E+ R R    EK++    +KLKE E+
Sbjct: 2088 NVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERER 2147

Query: 603  ERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQ 662
            E DS KDK               ++ L+ EL+ ++E+Q+   ++LD              
Sbjct: 2148 ENDSLKDK---------------VENLERELQMSEENQE--LVILD-------------- 2176

Query: 663  LMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAK 722
                 + SKAE+E L+ ++     +E   + K+ + D +     +  + E L K++    
Sbjct: 2177 ----AENSKAEVETLKTQI-----EEMARSLKVFELDLV----TLRSEKENLTKQI---- 2219

Query: 723  QEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIK-----------SN 771
            QE++  LSE+D    +F+ + E+  +   Q++E+     +++  ++K             
Sbjct: 2220 QEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQ 2279

Query: 772  QIHKLLK-------EEKEELADQVLTLKTQVDA----QLQVVRKLEEKEH---LLQSNIG 817
            +I K  +       EE+ +L + +  L+ +++A    QL V+++L+E EH   LL+  + 
Sbjct: 2280 EIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVE 2339

Query: 818  TGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMF 877
              E+EL +     E    +A  +    + LKA++E   + L   + ++V     KE    
Sbjct: 2340 NLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTN 2399

Query: 878  NFKRAQEDISRL 889
              ++ QE IS L
Sbjct: 2400 ELQKEQERISEL 2411



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 138/714 (19%), Positives = 292/714 (40%), Gaps = 62/714 (8%)

Query: 228 ENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIR----K 283
           +N     L D L+ +++ +  + ++L+ +++  E  +    +   +LQ  ++K +    +
Sbjct: 272 DNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIE 331

Query: 284 REQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRL 343
           +E+ LN+   E++          Y   S+ Y    T   +K +++  +L   ++ A++  
Sbjct: 332 KEKVLNKCRDELVRTTAQ-----YDQASTKY----TALEQKLKKLTEDLSCQRQNAESAR 382

Query: 344 CELE-----KLRQDFEEVTTQNEKLKVELRSAVEQVVKETPE-------YRCMQSQFSVL 391
           C LE     K ++  EE++ Q    +   +  ++   + T E       +  +Q++   L
Sbjct: 383 CSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKL 442

Query: 392 YNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLH-KKLRTEVIQLEDTLAQVRK 450
            +   QL+ +L+E +  L   R     Q   I+ +E+    ++++ E   L+    Q  +
Sbjct: 443 TSVKQQLENNLEEFKQKL--CRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAR 500

Query: 451 EYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKR-----KLREAQ 505
           E   L  E +       Q+     EM+   +S +     L+ ++ + +      KL+ A 
Sbjct: 501 EVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAV 560

Query: 506 SDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRD 565
           +DL K R  S   L + +   E   D+ ++ + +S+ L S     K   E+  E K+   
Sbjct: 561 ADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFS 620

Query: 566 EEERERERREKEREREREREKEKERERE-------------KQKLKESEKERDSAKDKEK 612
             + E E+   + E E+E  + K    E              ++++  E +R++   + +
Sbjct: 621 CWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIR 680

Query: 613 GKHD--DGRKKEAEIIKQLKIELKKA-----QESQKE---MKLLLDMYRSAPKEQRDKVQ 662
             H+  D +  E E  K   +EL++      Q+ QKE   M L         ++   K+Q
Sbjct: 681 NLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQ 740

Query: 663 LMAAEKKSKAE-LEDLRQRLKDLEDKEK-KENKKMADEDALRKIRAVEEQIEYLQKKLAM 720
           L++ E   K    +DL    + L D  K K+   + +ED  R + A ++Q   +    A 
Sbjct: 741 LLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQ-PAMHHSFAN 799

Query: 721 AKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEE 780
              E+ ++ SE     +   D   +N  ++Q     D   F L S++  ++ + K  +E 
Sbjct: 800 IIGEQGSMPSERSEC-RLEADQSPKNSAILQ--NRVDSLEFSLESQKQMNSDLQKQCEEL 856

Query: 781 KEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEA 840
            +   +    L          V +  ++   LQ +    +  +     ALE  +++    
Sbjct: 857 VQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLL 916

Query: 841 AQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLE 894
               +  +A+++  +K  H  +D + E  +  E      K     IS  +R++E
Sbjct: 917 NDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIE 970



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 155/751 (20%), Positives = 305/751 (40%), Gaps = 95/751 (12%)

Query: 168  EEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQ 227
            E++ ++ ++ +  +     Q  T Y  L++K++ L+  L S      E A   L   + +
Sbjct: 333  EKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDL-SCQRQNAESARCSLEQKIKE 391

Query: 228  ENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQR 287
            +    QE     Q   +T+ QE  ++++++      +   ++M + LQ ++DK+   +Q+
Sbjct: 392  KEKEFQEELSRQQRSFQTLDQECIQMKARLT---QELQQAKNMHNVLQAELDKLTSVKQQ 448

Query: 288  LNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINA--RKFEEMNAE---LEENKELAQNR 342
            L  +L E  +       K+  A  +     I  N   R  EEM  E   L+ + E     
Sbjct: 449  LENNLEEFKQ-------KLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKARE 501

Query: 343  LCELEKLRQDFEEVTTQNEKLKVELRS---AVEQVVKETPEYRCMQSQFSVLYNESLQLK 399
            +C LE   ++ ++   Q++    E+++   + E ++++  E   +  Q + L  E L+L 
Sbjct: 502  VCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEK--INQQENSLTLEKLKLA 559

Query: 400  -AHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIE 458
             A L++ R          +H +E +  D++S   K   E   L   L   +KEYE L+ E
Sbjct: 560  VADLEKQRDCSQDLLKKREHHIEQLN-DKLS---KTEKESKALLSALELKKKEYEELKEE 615

Query: 459  ---FEQTLAANEQA-GPINREMRHLISSLQNHNHQLKGEVLR---YKRKLREAQSDLNKT 511
               F    + NE+    +  E  +L S + +    LK + ++   Y  ++R  + D    
Sbjct: 616  KTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENL 675

Query: 512  R---------LRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQ-----EDA 557
                      L S S  +++Q        + AE          ++   K SQ     ED 
Sbjct: 676  SVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDL 735

Query: 558  NEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDS-AKDKEKGKHD 616
                     E  +++R  ++   E E  ++  + ++   +   + +R   A D++   H 
Sbjct: 736  EHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHH 795

Query: 617  -----------------------DGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSA 653
                                   D   K + I++     L+ + ESQK+M   L      
Sbjct: 796  SFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEE 855

Query: 654  PKEQRDKVQ--LMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQI 711
              + + +++  LM AE+  ++ + +  QR+  L++        +A+   L  +   E+++
Sbjct: 856  LVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAE--TLSALENKEKEL 913

Query: 712  EYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSN 771
            + L  K+    + E+A + E+  +    ED    +++ +Q L E      K MS  I  N
Sbjct: 914  QLLNDKV----ETEQAEIQELKKSNHLLED----SLKELQLLSETLSLEKKEMSSIISLN 965

Query: 772  QIHKLLKEEKEELADQVLTLKTQVDAQL-QVVRKLEEKEHLLQSNIGTGEKELGLRTQAL 830
                  K E EEL  +  TLK +++A L Q    L +K     + I   EK +   +   
Sbjct: 966  ------KREIEELTQENGTLK-EINASLNQEKMNLIQKSESFANYIDEREKSISELSDQY 1018

Query: 831  EMNK----RKAMEAAQLADDLKAQLELAQKK 857
            +  K    ++  E     +DL  + + AQ+K
Sbjct: 1019 KQEKLILLQRCEETGNAYEDLSQKYKAAQEK 1049



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 159/779 (20%), Positives = 310/779 (39%), Gaps = 116/779 (14%)

Query: 165  SSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSF 224
            SS +E     +E   +  + V ++ ++ +  ++ +E L  K+ S   ++  + +QEL   
Sbjct: 1529 SSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMES-QGIMKNKEIQELEQL 1587

Query: 225  LAQENMRLQELTDLLQEKHRTMSQEFS-KLQSKVETAESRVSVLESMIDDLQWDIDKIRK 283
            L+ E   L    D L++++ + ++++  KL S     ES+++  +   + L  +++  R 
Sbjct: 1588 LSSERQEL----DCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARL 1643

Query: 284  REQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRL 343
            + Q L+         ++S+         ++ G   + +  K E  +   E   +   +++
Sbjct: 1644 QLQGLD---------LSSRSLLGIDTEDAIQGRNESCDISK-EHTSETTERTPKHDVHQI 1693

Query: 344  CELEK---LRQDFEEVTTQNEKLKVELRSAVEQVV----------KETPEYRCMQS-QFS 389
            C+ +    L  D E++T +   +K     + EQ            K      C+    FS
Sbjct: 1694 CDKDAQQDLNLDIEKIT-ETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFS 1752

Query: 390  V---------------LYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKL 434
                            ++N  L++K   +E   LLH        +VE +  +   L  KL
Sbjct: 1753 GPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIED-RDRKVESLLNEMKELDSKL 1811

Query: 435  RTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQ--NHNHQLKG 492
              + +QL                + E  +   +  G + +E   L   L+  + +HQ   
Sbjct: 1812 HLQEVQL--------------MTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQ--- 1854

Query: 493  EVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKA 552
            E+L+         SDL          +   +SS ED  D  A++        S       
Sbjct: 1855 ELLQRVETSEGLNSDLE---------MHADKSSREDIGDNVAKVN------DSWKERFLD 1899

Query: 553  SQEDANEIKSKRDEEERERERREKEREREREREKEKERERE-KQKLKESEKERDSAKDKE 611
             + + + I+S++   E E    E + E  +  +   E++ E KQK+    +E  S    E
Sbjct: 1900 VENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSE 1959

Query: 612  KGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSK 671
            + +     + E + + +    L +  E  KE    L+ ++S   E    +Q+  AE K K
Sbjct: 1960 RNQ----LRGELDTMSKKTTALDQLSEKMKEKTQELESHQS---ECLHCIQVAEAEVKEK 2012

Query: 672  AEL-----EDLRQRLKDLEDKEKKENKKMADEDALRKIRA-VEEQIEYLQKKLAMAKQEE 725
             EL      D+ + LKD    ++K      D  AL   +  +E QI  L K+  +  +E 
Sbjct: 2013 TELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKES 2072

Query: 726  EALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELA 785
            E+L + +  +     D ++ N+    +    +   F L   R+ S Q      EE  +L 
Sbjct: 2073 ESLQARLSES-----DYEKLNVSKALEAALVEKGEFAL---RLSSTQ------EEVHQLR 2118

Query: 786  DQVLTLKTQVDA----QLQVVRKLEEKEH---LLQSNIGTGEKELGLRTQALEMNKRKAM 838
              +  L+ +++A    QL +  KL+E+E     L+  +   E+EL +  +  E+    A 
Sbjct: 2119 RGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAE 2178

Query: 839  EAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTK 897
             +    + LK Q+E   + L  F+ ++V     KE      +  Q  +S L + L + K
Sbjct: 2179 NSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFK 2237



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 149/851 (17%), Positives = 339/851 (39%), Gaps = 133/851 (15%)

Query: 20   EKKAAVEDSGTTVETIKLGGVSSTEELDIRT--LQTKNRKLAEMLDQRQAIEDELREHIE 77
            ++K   +++  T+E +KL      ++ D     L+ +   + ++ D+    E E +  + 
Sbjct: 541  QEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLS 600

Query: 78   KLERRQATDDASLLIVNRYWSQFDENIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSD 137
             LE ++   +        +     EN +++ +    ++ L   +   +  +  +     +
Sbjct: 601  ALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHE 660

Query: 138  SNQERKDDRERGEGQEPAFSFLATLASSSSEEMESQ------LQERVESSRRA------- 184
             N+  +      E        L  +  S S E+E+Q      LQ++ E S +        
Sbjct: 661  YNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIEN 720

Query: 185  ----VSQIVTVYDKLQEKVELLSRKLNSGDNLIVE-----EAVQEL-------------- 221
                 SQ+    + L+ K++LLS ++   D    +     E++++L              
Sbjct: 721  MCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDH 780

Query: 222  -NSFLA--QENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDI 278
              S LA  Q+        +++ E+  +M  E S+ + + + +    ++L++ +D L++ +
Sbjct: 781  QRSLLAFDQQPAMHHSFANIIGEQG-SMPSERSECRLEADQSPKNSAILQNRVDSLEFSL 839

Query: 279  DKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMN--------- 329
            +  ++    L +   E+++                  G I  N  K E+M+         
Sbjct: 840  ESQKQMNSDLQKQCEELVQ----------------IKGEIEENLMKAEQMHQSFVAETSQ 883

Query: 330  --AELEENKELAQNRLCE-LEKLRQDFEEVTTQNEKLKVELRSAVE-------------- 372
              ++L+E+    QN + E L  L    +E+   N+K++ E     E              
Sbjct: 884  RISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKE 943

Query: 373  -QVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEV--- 428
             Q++ ET      +   S++     +++    E  TL       +Q ++ LI++ E    
Sbjct: 944  LQLLSETLSLE-KKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFAN 1002

Query: 429  ----------SLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRH 478
                       L  + + E + L     +    YE L  +++     N +   +  E   
Sbjct: 1003 YIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTS 1062

Query: 479  LISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKP 538
            L  + +N   QLK     + ++ +E  + L     R+ + +L+ ++  +  + E  +   
Sbjct: 1063 LCENRKNELEQLKEA---FAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTD--- 1116

Query: 539  DSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLK 598
                 +S+S A    QE    I + ++E+ + ++      +   +  K  + + E Q L 
Sbjct: 1117 --NQNNSKSEAGGLKQE----IMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNL- 1169

Query: 599  ESEKERDSAKDKEKGKHDDGRKKEAEI-IKQLKIELKKAQESQKEMKLLLDMYRSAPKEQ 657
            ESE  R+S K++E  ++    K + ++ +K++ ++   AQ  Q E  L           +
Sbjct: 1170 ESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAML-----------R 1218

Query: 658  RDKVQLMAAEKKSKA---ELEDLRQRLK--DLEDKEKKE--NKKMADEDALRKIRAVEEQ 710
              +++L  +EK+ +    EL+ +R  L+  +L+D + +E    K  + DA  K  +   +
Sbjct: 1219 NKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHE 1278

Query: 711  IEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKS 770
            +   Q   A  +   +  +++++   +  E +Q +   L+ +L   D  +  + + R  +
Sbjct: 1279 LSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTEL--NDSRSECITATRKMA 1336

Query: 771  NQIHKLLKEEK 781
             ++ KLL E K
Sbjct: 1337 EEVGKLLNEVK 1347



 Score = 57.0 bits (136), Expect = 8e-08
 Identities = 146/735 (19%), Positives = 289/735 (39%), Gaps = 91/735 (12%)

Query: 232  LQELTDLLQEKHR-------TMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKR 284
            LQE    LQ +H+        MS + S+LQ+ V++ ++   VL + + + Q D+ K    
Sbjct: 1407 LQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVK---- 1462

Query: 285  EQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKE--LAQNR 342
            E +L   L E L    S       +  S  G +    A   +  +  L  N E  ++ N+
Sbjct: 1463 EMQLG--LEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQ 1520

Query: 343  LCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYR-CMQSQFSVLYNESLQLKAH 401
                E      +E     ++        VE++      YR  ++     + ++ +     
Sbjct: 1521 CSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKE 1580

Query: 402  LDEARTLLHGTRGTHQHQVELIERDEVS----LHKKLRTEVIQLEDTLAQVRKEYEMLRI 457
            + E   LL   R     +++ + +  +S      +KL +  +++E  LA  +K+ E L +
Sbjct: 1581 IQELEQLLSSER----QELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSL 1636

Query: 458  EFEQTLAANEQAGPINREMRHLI-----SSLQNHN--------HQLKGEVLRYKRKL--- 501
            E E    A  Q   ++   R L+      ++Q  N        H  +      K  +   
Sbjct: 1637 ELE---VARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQI 1693

Query: 502  --REAQSDLN---KTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQED 556
              ++AQ DLN   +    +G+     + S E   D   E   + +   S    S+ S   
Sbjct: 1694 CDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSG 1753

Query: 557  ANE------IKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDK 610
             N       + ++ D    +   +E   E  R     ++R+R+ + L    KE DS    
Sbjct: 1754 PNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHL 1813

Query: 611  EKGKHDDGRKKEAEI-IKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQL------ 663
            ++ +     K EA I ++++  ELKK      E    L+ +    +E   +V+       
Sbjct: 1814 QEVQL--MTKIEACIELEKIVGELKKENSDLSEK---LEYFSCDHQELLQRVETSEGLNS 1868

Query: 664  ---MAAEKKSKAELED--------LRQRLKDLE--------DKEKKENKKMADEDALRKI 704
               M A+K S+ ++ D         ++R  D+E        +K   E++ +  E  L  +
Sbjct: 1869 DLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVV 1928

Query: 705  R----AVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDAN 760
            +     +E+  E  QK +   ++E   + SE +      + M ++   L Q   +  +  
Sbjct: 1929 QTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKT 1988

Query: 761  FKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEK-EHLLQSNIGTG 819
             +L S + +     ++ + E +E  + + TL + V   L+    L+EK + L + +    
Sbjct: 1989 QELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALS 2048

Query: 820  EKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNF 879
              +  L  Q  ++NK K +   + ++ L+A+L  +  +  +    +    V K +     
Sbjct: 2049 LTKCELENQIAQLNKEKELLVKE-SESLQARLSESDYEKLNVSKALEAALVEKGEFALRL 2107

Query: 880  KRAQEDISRLRRKLE 894
               QE++ +LRR +E
Sbjct: 2108 SSTQEEVHQLRRGIE 2122



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 86/424 (20%), Positives = 176/424 (41%), Gaps = 67/424 (15%)

Query: 535 ELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREKEKEREREK 594
           +LK + +    Q  + +A+ +     K K+  E  + E    +RE +R  E  +  E+ K
Sbjct: 29  KLKKEKQQRQFQLDSLEAALQ-----KQKQKVENEKTEGTNLKRENQRLMEICESLEKTK 83

Query: 595 QKLKESEKERDSAKDKEKGKHDDGRK---KEAEIIKQLKIELKKAQESQKEMKLLLDMYR 651
           QK+    + ++S  + ++G+ + G+K   K  + +K+ K EL+++Q++ +   + L+   
Sbjct: 84  QKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCN 143

Query: 652 SAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKM-ADEDALRKIRAVE-- 708
           +  K       L  ++  S ++ EDL+++     +KE +E K++ A+  AL+  +A +  
Sbjct: 144 TPQK--IFTTPLTPSQYYSGSKYEDLKEKY----NKEVEERKRLEAEVKALQAKKASQTL 197

Query: 709 -------EQIEYLQKKLAMAKQEEEALLSEM-----------DVTGQAFEDMQEQNIRLM 750
                    I   Q   ++   ++E   S +           D +   F   QE      
Sbjct: 198 PQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRS 257

Query: 751 QQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEH 810
                K DAN     +   S  +   LK + +EL +++  L+ ++    + ++    K  
Sbjct: 258 TLQIGKRDANSSFF-DNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQ 316

Query: 811 LLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEI----- 865
            LQ  +   + EL  + + L   + + +      D    +    ++KL    +++     
Sbjct: 317 ELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQ 376

Query: 866 --------VENSVTKEKDMFNFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDYK 917
                   +E  + KEK+    K  QE++SR +R  +T             L +E    K
Sbjct: 377 NAESARCSLEQKI-KEKE----KEFQEELSRQQRSFQT-------------LDQECIQMK 418

Query: 918 ARLT 921
           ARLT
Sbjct: 419 ARLT 422


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  123 bits (308), Expect = 1e-27
 Identities = 194/921 (21%), Positives = 390/921 (42%), Gaps = 170/921 (18%)

Query: 51   LQTKNRKLAEMLDQRQAIEDELREHIEKLER-----RQATDDASLLI--VNRYWSQFDEN 103
            L+ K +++ E  +  + I  EL     KLE      ++  DD  L +  V +     +  
Sbjct: 921  LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 980

Query: 104  IRIILKRY-DLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATL 162
            ++ + +    L++ +  L  E+KAL         +++Q+  DD +  E +    +     
Sbjct: 981  VKNLTEEMAGLDETIAKLTKEKKAL--------QEAHQQTLDDLQAEEDKVNTLTKAKIK 1032

Query: 163  ASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELN 222
                 +++E  L++                 KL+  +E   RKL  GD  + +E++ ++ 
Sbjct: 1033 LEQQVDDLEGSLEQE---------------KKLRMDLERAKRKLE-GDLKLAQESIMDI- 1075

Query: 223  SFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAES-------RVSVLESMIDDLQ 275
                 EN + Q     L EK +    E S LQSK+E  ++       ++  L++ I++L+
Sbjct: 1076 -----ENEKQQ-----LDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELE 1125

Query: 276  WDID-------KIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEM 328
             +I+       K  K+   L+R L E+ ER+   G           G T           
Sbjct: 1126 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAG-----------GAT----------- 1163

Query: 329  NAELEENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPE-YRCMQSQ 387
            +A++E NK+    R  E +K+R+D EE T Q+E     LR      V E  E    +Q  
Sbjct: 1164 SAQIEMNKK----REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV 1219

Query: 388  FSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQ 447
               L  E  ++K  +D+  +            VE + + + +L K  RT    LED L++
Sbjct: 1220 KQKLEKEKSEMKMEIDDLAS-----------NVETVSKAKGNLEKMCRT----LEDQLSE 1264

Query: 448  VR-KEYEMLRIEFEQTLAANE---QAGPINR---EMRHLISSLQNHNHQLKGEVLRYKRK 500
            ++ KE E  R+  + T        ++G  +R   E   L+S L         ++   KR+
Sbjct: 1265 LKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQ 1324

Query: 501  LREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSS--QSSASKASQEDAN 558
            L E         +++ +AL  +  S+    D   E   + ++  +  Q + SKA+ E A 
Sbjct: 1325 LEE--------EIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQ 1376

Query: 559  -EIKSKRDEEERERERREKEREREREREKEKER-----------EREKQKLKES------ 600
               K + D  +R  E  E +++  +  +  +E            E+ KQ+L+        
Sbjct: 1377 WRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1436

Query: 601  EKERDSAK----DKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKE 656
            + ER +A     DK++   D    +  +  ++   EL+ +Q+  + +   L   ++A +E
Sbjct: 1437 DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE 1496

Query: 657  QRDKVQLMAAEKKS-KAELEDLRQ-------RLKDLEDKEKKENKKMAD-----EDALRK 703
              D+++ +  E K+ + E+ DL +       R+ +LE  +K+  ++  +     E+A   
Sbjct: 1497 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEAS 1556

Query: 704  IRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKL 763
            +   E +I  +Q +L   K E +  ++E D   +  + ++  +IR+++ ++   DA  + 
Sbjct: 1557 LEHEEGKILRIQLELNQVKSEVDRKIAEKD---EEIDQLKRNHIRIVESMQSTLDAEIRS 1613

Query: 764  MSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLL---QSNIGTGE 820
             ++ I      +L K+ + +L +  + L        + +R     + +L   Q ++    
Sbjct: 1614 RNDAI------RLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDAL 1667

Query: 821  KELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSV------TKEK 874
            +      + L M +R+A       ++L+A LE  ++     + E+++ S       T+  
Sbjct: 1668 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1727

Query: 875  DMFNFKRAQE-DISRLRRKLE 894
             + N K+  E DIS+++ ++E
Sbjct: 1728 SLINTKKKLETDISQMQGEME 1748



 Score =  105 bits (262), Expect = 2e-22
 Identities = 161/789 (20%), Positives = 341/789 (43%), Gaps = 102/789 (12%)

Query: 57   KLAEMLDQRQAIEDELREHIEKLERRQATDD--ASLLIVNRYWSQFDENIRII------L 108
            +L E +D  Q ++ +L +  EK E +   DD  +++  V++     ++  R +      L
Sbjct: 1208 ELGEQIDNLQRVKQKLEK--EKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSEL 1265

Query: 109  KRYDLEQG--LGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSS 166
            K  + EQ   + DL  +R  L     E     +++     +   G++     +  L    
Sbjct: 1266 KSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL 1325

Query: 167  SEEMESQ--LQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSF 224
             EE++++  L   ++SSR     +   Y++ QE    L R L+  +     E  Q    +
Sbjct: 1326 EEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANT----EVAQWRTKY 1381

Query: 225  LAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKR 284
                  R +EL    +E  + ++Q     +  VE   ++ + LE     LQ +++ +   
Sbjct: 1382 ETDAIQRTEEL----EEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD 1437

Query: 285  EQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLC 344
             +R N   A  L++      K+                +K EE +AELE +++ A++   
Sbjct: 1438 VERTNAACA-ALDKKQRNFDKILAEWK-----------QKCEETHAELEASQKEARSLGT 1485

Query: 345  ELEKLRQDFEEVTTQ-------NEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQ 397
            EL K++  +EE   Q       N+ L+ E+    EQ+ +       ++     +  E  +
Sbjct: 1486 ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCE 1545

Query: 398  LKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEY----E 453
            L+A L+EA   L    G    ++  I+ +   +  ++  ++ + ++ + Q+++ +    E
Sbjct: 1546 LQAALEEAEASLEHEEG----KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVE 1601

Query: 454  MLRIEFEQTLAANEQAGPINREMRHLISSLQ---NHNHQLKGEVLRYKRKLREAQSDLNK 510
             ++   +  + +   A  + ++M   ++ ++   NH +++  E LR     R  Q  L  
Sbjct: 1602 SMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALR---NYRNTQGILKD 1658

Query: 511  TRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERE 570
            T++    AL     S ED K++ A ++  +  L ++    +A+ E            + E
Sbjct: 1659 TQIHLDDAL----RSQEDLKEQLAMVERRANLLQAEIEELRATLE------------QTE 1702

Query: 571  RERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLK 630
            R R+  E+E     E+ +    +   L  ++K+ ++   + +G+ +D       I+++ +
Sbjct: 1703 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMED-------ILQEAR 1755

Query: 631  IELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKK 690
               +KA+++  +  ++ +  +   KEQ     L   +K  +  ++DL+ RL + E    K
Sbjct: 1756 NAEEKAKKAITDAAMMAEELK---KEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALK 1812

Query: 691  ENKKMADEDALRKIRAVEEQIEYLQKKLAMA---KQEEEALLSEMDVTGQAFEDMQEQNI 747
              KK   +   R +R +E ++E  QK+ A A    ++ E  + E+  T Q  ED   +NI
Sbjct: 1813 GGKKQIQKLEAR-VRELEGEVESEQKRNAEAVKGLRKHERRVKEL--TYQTEED--RKNI 1867

Query: 748  RLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEE 807
              +Q L +K       +  ++KS   +K   EE EE ++  L    ++  +L+   + EE
Sbjct: 1868 LRLQDLVDK-------LQAKVKS---YKRQAEEAEEQSNTNLAKFRKLQHELE---EAEE 1914

Query: 808  KEHLLQSNI 816
            +  + +S +
Sbjct: 1915 RADIAESQV 1923



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 111/492 (22%), Positives = 213/492 (43%), Gaps = 43/492 (8%)

Query: 446  AQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQ 505
            A+  KE   ++ EF++      ++    +E+   + +L    + L+ +V      L +A+
Sbjct: 849  AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE 908

Query: 506  S---DLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKS 562
                 L KT+++  + + +     ED ++  AEL      L  + S  K   +D     +
Sbjct: 909  ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 968

Query: 563  KRDEEERERERREKERERER----------EREKEKEREREKQKLKESEKERDSAKDKEK 612
            K ++E+   E + K    E            +EK+  +E  +Q L + + E D      K
Sbjct: 969  KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1028

Query: 613  GK-----HDDGRKKEAEIIKQLKIELKKAQES-QKEMKLLLDMYRSAPKEQRDKVQLMAA 666
             K       D  +   E  K+L+++L++A+   + ++KL  +   S    + +K QL   
Sbjct: 1029 AKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE---SIMDIENEKQQLDEK 1085

Query: 667  EKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEE 726
             KK + E+ +L+ +++D +    +  KK+ +  A  +I  +EE+IE  +   A A+++  
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQLQKKIKELQA--RIEELEEEIEAERASRAKAEKQRS 1143

Query: 727  ALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIK--SNQIHKLLKEEKEEL 784
             L  E++   +  E+        + ++ +K +A F+ M   ++  + Q        +++ 
Sbjct: 1144 DLSRELEEISERLEEAGGATSAQI-EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKH 1202

Query: 785  ADQVLTLKTQVDAQLQVVRKLE-EKEHL------LQSNIGTGEKELG--------LRTQA 829
            AD V  L  Q+D   +V +KLE EK  +      L SN+ T  K  G        L  Q 
Sbjct: 1203 ADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQL 1262

Query: 830  LEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRL 889
             E+ K K  E  +L +DL AQ    Q +  +F  ++ E      +     +   + I  L
Sbjct: 1263 SEL-KSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEEL 1321

Query: 890  RRKLETTKKPDN 901
            +R+LE   K  N
Sbjct: 1322 KRQLEEEIKAKN 1333



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 81/349 (23%), Positives = 159/349 (45%), Gaps = 58/349 (16%)

Query: 560  IKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHD--- 616
            +KS   E+E    + E ++ ++   + E +R+  ++K+    KE++  + + + + +   
Sbjct: 846  LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA 905

Query: 617  DGRKKEAEIIK---QLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAE 673
            D  ++  ++IK   QL+ ++K+  E              A  E+    +L A ++K + E
Sbjct: 906  DAEERCDQLIKTKIQLEAKIKEVTE-------------RAEDEEEINAELTAKKRKLEDE 952

Query: 674  LEDLRQRLKDLE-DKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEM 732
              +L++ + DLE    K E +K A E+   K++ + E++  L + +A   +E++AL    
Sbjct: 953  CSELKKDIDDLELTLAKVEKEKHATEN---KVKNLTEEMAGLDETIAKLTKEKKAL---- 1005

Query: 733  DVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQ----IHKLLKEEKEELADQV 788
                      QE + + +  L+ ++D    L   +IK  Q    +   L++EK       
Sbjct: 1006 ----------QEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEK------- 1048

Query: 789  LTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLK 848
               K ++D + +  RKLE    L Q +I   E E   + Q  E  K+K  E + L   ++
Sbjct: 1049 ---KLRMDLE-RAKRKLEGDLKLAQESIMDIENE---KQQLDEKLKKKEFEISNLQSKIE 1101

Query: 849  AQLELA---QKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLE 894
             +  L    QKK+ + Q  I E     E +  +  +A++  S L R+LE
Sbjct: 1102 DEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELE 1150



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 84/476 (17%), Positives = 197/476 (41%), Gaps = 42/476 (8%)

Query: 168  EEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQ 227
            EE  ++L+   + +R   +++  + +  +E ++ L        NL  ++ + +L   +A+
Sbjct: 1467 EETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNL--QQEISDLTEQIAE 1524

Query: 228  ENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQR 287
               R+ EL  + ++    + QE  +LQ+ +E AE+ +   E  I  +Q ++++++    R
Sbjct: 1525 GGKRIHELEKIKKQ----VEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1580

Query: 288  LNRHLAEVLERVNSKGYKVYGAGSSLYGGTITIN---ARKFEEMNAELEENK-ELAQNRL 343
                  E ++++     ++  +  S     I       R  ++M  +L E + +L     
Sbjct: 1581 KIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANR 1640

Query: 344  CELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLD 403
               E LR ++       +  ++ L  A+        +   ++ + ++L  E  +L+A L+
Sbjct: 1641 MAAEALR-NYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLE 1699

Query: 404  E---ARTLLHGTRGTHQHQVELIERDEVSL---HKKLRTEVIQL----EDTLAQVRKEYE 453
            +   +R +          +V+L+     SL    KKL T++ Q+    ED L + R   E
Sbjct: 1700 QTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEE 1759

Query: 454  ----------MLRIEFEQTLAANEQAGPINREMRHLISSLQ---NHNHQL-----KGEVL 495
                      M+  E ++    +     + + M   +  LQ   +   QL     K ++ 
Sbjct: 1760 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQ 1819

Query: 496  RYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQE 555
            + + ++RE + ++   + R+  A+   +      K+   + + D +++          Q 
Sbjct: 1820 KLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQA 1879

Query: 556  DANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKE 611
               ++KS + + E   E+      + R+ + E E   E+  + ES+  +   K +E
Sbjct: 1880 ---KVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSRE 1932



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 68/304 (22%), Positives = 124/304 (40%), Gaps = 36/304 (11%)

Query: 62   LDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDENIRIILKRY-DLEQGLGDL 120
            LD     +++L+E +  +ERR     A +  +     Q + + +I  +   D  + +  L
Sbjct: 1663 LDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLL 1722

Query: 121  LTERKALVVPEPEPDSDSNQ---ERKDDRERGEGQEPAFSFLATLASSSSEEM--ESQLQ 175
             T+  +L+  + + ++D +Q   E +D  +     E       T A+  +EE+  E    
Sbjct: 1723 HTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTS 1782

Query: 176  ERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQENMRLQEL 235
              +E  ++ + Q V       ++ E L+ K        +E  V+EL   +  E  R  E 
Sbjct: 1783 AHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEA 1842

Query: 236  TDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEV 295
               L+ KH    +E +      +T E R ++L      LQ  +DK++ + +   R   E 
Sbjct: 1843 VKGLR-KHERRVKELT-----YQTEEDRKNILR-----LQDLVDKLQAKVKSYKRQAEEA 1891

Query: 296  LERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDFEE 355
             E+ N+                   N  KF ++  ELEE +E A     ++ KLR    E
Sbjct: 1892 EEQSNT-------------------NLAKFRKLQHELEEAEERADIAESQVNKLRVKSRE 1932

Query: 356  VTTQ 359
            V T+
Sbjct: 1933 VHTK 1936


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  123 bits (308), Expect = 1e-27
 Identities = 194/921 (21%), Positives = 390/921 (42%), Gaps = 170/921 (18%)

Query: 51   LQTKNRKLAEMLDQRQAIEDELREHIEKLER-----RQATDDASLLI--VNRYWSQFDEN 103
            L+ K +++ E  +  + I  EL     KLE      ++  DD  L +  V +     +  
Sbjct: 921  LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 980

Query: 104  IRIILKRY-DLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATL 162
            ++ + +    L++ +  L  E+KAL         +++Q+  DD +  E +    +     
Sbjct: 981  VKNLTEEMAGLDETIAKLTKEKKAL--------QEAHQQTLDDLQAEEDKVNTLTKAKIK 1032

Query: 163  ASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELN 222
                 +++E  L++                 KL+  +E   RKL  GD  + +E++ ++ 
Sbjct: 1033 LEQQVDDLEGSLEQE---------------KKLRMDLERAKRKLE-GDLKLAQESIMDI- 1075

Query: 223  SFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAES-------RVSVLESMIDDLQ 275
                 EN + Q     L EK +    E S LQSK+E  ++       ++  L++ I++L+
Sbjct: 1076 -----ENEKQQ-----LDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELE 1125

Query: 276  WDID-------KIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEM 328
             +I+       K  K+   L+R L E+ ER+   G           G T           
Sbjct: 1126 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAG-----------GAT----------- 1163

Query: 329  NAELEENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPE-YRCMQSQ 387
            +A++E NK+    R  E +K+R+D EE T Q+E     LR      V E  E    +Q  
Sbjct: 1164 SAQIEMNKK----REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV 1219

Query: 388  FSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQ 447
               L  E  ++K  +D+  +            VE + + + +L K  RT    LED L++
Sbjct: 1220 KQKLEKEKSEMKMEIDDLAS-----------NVETVSKAKGNLEKMCRT----LEDQLSE 1264

Query: 448  VR-KEYEMLRIEFEQTLAANE---QAGPINR---EMRHLISSLQNHNHQLKGEVLRYKRK 500
            ++ KE E  R+  + T        ++G  +R   E   L+S L         ++   KR+
Sbjct: 1265 LKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQ 1324

Query: 501  LREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSS--QSSASKASQEDAN 558
            L E         +++ +AL  +  S+    D   E   + ++  +  Q + SKA+ E A 
Sbjct: 1325 LEE--------EIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQ 1376

Query: 559  -EIKSKRDEEERERERREKEREREREREKEKER-----------EREKQKLKES------ 600
               K + D  +R  E  E +++  +  +  +E            E+ KQ+L+        
Sbjct: 1377 WRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1436

Query: 601  EKERDSAK----DKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKE 656
            + ER +A     DK++   D    +  +  ++   EL+ +Q+  + +   L   ++A +E
Sbjct: 1437 DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE 1496

Query: 657  QRDKVQLMAAEKKS-KAELEDLRQ-------RLKDLEDKEKKENKKMAD-----EDALRK 703
              D+++ +  E K+ + E+ DL +       R+ +LE  +K+  ++  +     E+A   
Sbjct: 1497 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEAS 1556

Query: 704  IRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKL 763
            +   E +I  +Q +L   K E +  ++E D   +  + ++  +IR+++ ++   DA  + 
Sbjct: 1557 LEHEEGKILRIQLELNQVKSEVDRKIAEKD---EEIDQLKRNHIRIVESMQSTLDAEIRS 1613

Query: 764  MSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLL---QSNIGTGE 820
             ++ I      +L K+ + +L +  + L        + +R     + +L   Q ++    
Sbjct: 1614 RNDAI------RLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDAL 1667

Query: 821  KELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSV------TKEK 874
            +      + L M +R+A       ++L+A LE  ++     + E+++ S       T+  
Sbjct: 1668 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1727

Query: 875  DMFNFKRAQE-DISRLRRKLE 894
             + N K+  E DIS+++ ++E
Sbjct: 1728 SLINTKKKLETDISQMQGEME 1748



 Score =  105 bits (262), Expect = 2e-22
 Identities = 161/789 (20%), Positives = 341/789 (43%), Gaps = 102/789 (12%)

Query: 57   KLAEMLDQRQAIEDELREHIEKLERRQATDD--ASLLIVNRYWSQFDENIRII------L 108
            +L E +D  Q ++ +L +  EK E +   DD  +++  V++     ++  R +      L
Sbjct: 1208 ELGEQIDNLQRVKQKLEK--EKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSEL 1265

Query: 109  KRYDLEQG--LGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSS 166
            K  + EQ   + DL  +R  L     E     +++     +   G++     +  L    
Sbjct: 1266 KSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL 1325

Query: 167  SEEMESQ--LQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSF 224
             EE++++  L   ++SSR     +   Y++ QE    L R L+  +     E  Q    +
Sbjct: 1326 EEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANT----EVAQWRTKY 1381

Query: 225  LAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKR 284
                  R +EL    +E  + ++Q     +  VE   ++ + LE     LQ +++ +   
Sbjct: 1382 ETDAIQRTEEL----EEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD 1437

Query: 285  EQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLC 344
             +R N   A  L++      K+                +K EE +AELE +++ A++   
Sbjct: 1438 VERTNAACA-ALDKKQRNFDKILAEWK-----------QKCEETHAELEASQKEARSLGT 1485

Query: 345  ELEKLRQDFEEVTTQ-------NEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQ 397
            EL K++  +EE   Q       N+ L+ E+    EQ+ +       ++     +  E  +
Sbjct: 1486 ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCE 1545

Query: 398  LKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEY----E 453
            L+A L+EA   L    G    ++  I+ +   +  ++  ++ + ++ + Q+++ +    E
Sbjct: 1546 LQAALEEAEASLEHEEG----KILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVE 1601

Query: 454  MLRIEFEQTLAANEQAGPINREMRHLISSLQ---NHNHQLKGEVLRYKRKLREAQSDLNK 510
             ++   +  + +   A  + ++M   ++ ++   NH +++  E LR     R  Q  L  
Sbjct: 1602 SMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALR---NYRNTQGILKD 1658

Query: 511  TRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERE 570
            T++    AL     S ED K++ A ++  +  L ++    +A+ E            + E
Sbjct: 1659 TQIHLDDAL----RSQEDLKEQLAMVERRANLLQAEIEELRATLE------------QTE 1702

Query: 571  RERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLK 630
            R R+  E+E     E+ +    +   L  ++K+ ++   + +G+ +D       I+++ +
Sbjct: 1703 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMED-------ILQEAR 1755

Query: 631  IELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKK 690
               +KA+++  +  ++ +  +   KEQ     L   +K  +  ++DL+ RL + E    K
Sbjct: 1756 NAEEKAKKAITDAAMMAEELK---KEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALK 1812

Query: 691  ENKKMADEDALRKIRAVEEQIEYLQKKLAMA---KQEEEALLSEMDVTGQAFEDMQEQNI 747
              KK   +   R +R +E ++E  QK+ A A    ++ E  + E+  T Q  ED   +NI
Sbjct: 1813 GGKKQIQKLEAR-VRELEGEVESEQKRNAEAVKGLRKHERRVKEL--TYQTEED--RKNI 1867

Query: 748  RLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEE 807
              +Q L +K       +  ++KS   +K   EE EE ++  L    ++  +L+   + EE
Sbjct: 1868 LRLQDLVDK-------LQAKVKS---YKRQAEEAEEQSNTNLAKFRKLQHELE---EAEE 1914

Query: 808  KEHLLQSNI 816
            +  + +S +
Sbjct: 1915 RADIAESQV 1923



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 111/492 (22%), Positives = 213/492 (43%), Gaps = 43/492 (8%)

Query: 446  AQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQ 505
            A+  KE   ++ EF++      ++    +E+   + +L    + L+ +V      L +A+
Sbjct: 849  AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE 908

Query: 506  S---DLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKS 562
                 L KT+++  + + +     ED ++  AEL      L  + S  K   +D     +
Sbjct: 909  ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 968

Query: 563  KRDEEERERERREKERERER----------EREKEKEREREKQKLKESEKERDSAKDKEK 612
            K ++E+   E + K    E            +EK+  +E  +Q L + + E D      K
Sbjct: 969  KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1028

Query: 613  GK-----HDDGRKKEAEIIKQLKIELKKAQES-QKEMKLLLDMYRSAPKEQRDKVQLMAA 666
             K       D  +   E  K+L+++L++A+   + ++KL  +   S    + +K QL   
Sbjct: 1029 AKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE---SIMDIENEKQQLDEK 1085

Query: 667  EKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEE 726
             KK + E+ +L+ +++D +    +  KK+ +  A  +I  +EE+IE  +   A A+++  
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQLQKKIKELQA--RIEELEEEIEAERASRAKAEKQRS 1143

Query: 727  ALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIK--SNQIHKLLKEEKEEL 784
             L  E++   +  E+        + ++ +K +A F+ M   ++  + Q        +++ 
Sbjct: 1144 DLSRELEEISERLEEAGGATSAQI-EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKH 1202

Query: 785  ADQVLTLKTQVDAQLQVVRKLE-EKEHL------LQSNIGTGEKELG--------LRTQA 829
            AD V  L  Q+D   +V +KLE EK  +      L SN+ T  K  G        L  Q 
Sbjct: 1203 ADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQL 1262

Query: 830  LEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRL 889
             E+ K K  E  +L +DL AQ    Q +  +F  ++ E      +     +   + I  L
Sbjct: 1263 SEL-KSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEEL 1321

Query: 890  RRKLETTKKPDN 901
            +R+LE   K  N
Sbjct: 1322 KRQLEEEIKAKN 1333



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 81/349 (23%), Positives = 159/349 (45%), Gaps = 58/349 (16%)

Query: 560  IKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHD--- 616
            +KS   E+E    + E ++ ++   + E +R+  ++K+    KE++  + + + + +   
Sbjct: 846  LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLA 905

Query: 617  DGRKKEAEIIK---QLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAE 673
            D  ++  ++IK   QL+ ++K+  E              A  E+    +L A ++K + E
Sbjct: 906  DAEERCDQLIKTKIQLEAKIKEVTE-------------RAEDEEEINAELTAKKRKLEDE 952

Query: 674  LEDLRQRLKDLE-DKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEM 732
              +L++ + DLE    K E +K A E+   K++ + E++  L + +A   +E++AL    
Sbjct: 953  CSELKKDIDDLELTLAKVEKEKHATEN---KVKNLTEEMAGLDETIAKLTKEKKAL---- 1005

Query: 733  DVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQ----IHKLLKEEKEELADQV 788
                      QE + + +  L+ ++D    L   +IK  Q    +   L++EK       
Sbjct: 1006 ----------QEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEK------- 1048

Query: 789  LTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLK 848
               K ++D + +  RKLE    L Q +I   E E   + Q  E  K+K  E + L   ++
Sbjct: 1049 ---KLRMDLE-RAKRKLEGDLKLAQESIMDIENE---KQQLDEKLKKKEFEISNLQSKIE 1101

Query: 849  AQLELA---QKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLE 894
             +  L    QKK+ + Q  I E     E +  +  +A++  S L R+LE
Sbjct: 1102 DEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELE 1150



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 84/476 (17%), Positives = 197/476 (41%), Gaps = 42/476 (8%)

Query: 168  EEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQ 227
            EE  ++L+   + +R   +++  + +  +E ++ L        NL  ++ + +L   +A+
Sbjct: 1467 EETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNL--QQEISDLTEQIAE 1524

Query: 228  ENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQR 287
               R+ EL  + ++    + QE  +LQ+ +E AE+ +   E  I  +Q ++++++    R
Sbjct: 1525 GGKRIHELEKIKKQ----VEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1580

Query: 288  LNRHLAEVLERVNSKGYKVYGAGSSLYGGTITIN---ARKFEEMNAELEENK-ELAQNRL 343
                  E ++++     ++  +  S     I       R  ++M  +L E + +L     
Sbjct: 1581 KIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANR 1640

Query: 344  CELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLD 403
               E LR ++       +  ++ L  A+        +   ++ + ++L  E  +L+A L+
Sbjct: 1641 MAAEALR-NYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLE 1699

Query: 404  E---ARTLLHGTRGTHQHQVELIERDEVSL---HKKLRTEVIQL----EDTLAQVRKEYE 453
            +   +R +          +V+L+     SL    KKL T++ Q+    ED L + R   E
Sbjct: 1700 QTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEE 1759

Query: 454  ----------MLRIEFEQTLAANEQAGPINREMRHLISSLQ---NHNHQL-----KGEVL 495
                      M+  E ++    +     + + M   +  LQ   +   QL     K ++ 
Sbjct: 1760 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQ 1819

Query: 496  RYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQE 555
            + + ++RE + ++   + R+  A+   +      K+   + + D +++          Q 
Sbjct: 1820 KLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQA 1879

Query: 556  DANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKE 611
               ++KS + + E   E+      + R+ + E E   E+  + ES+  +   K +E
Sbjct: 1880 ---KVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSRE 1932



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 68/304 (22%), Positives = 124/304 (40%), Gaps = 36/304 (11%)

Query: 62   LDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDENIRIILKRY-DLEQGLGDL 120
            LD     +++L+E +  +ERR     A +  +     Q + + +I  +   D  + +  L
Sbjct: 1663 LDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLL 1722

Query: 121  LTERKALVVPEPEPDSDSNQ---ERKDDRERGEGQEPAFSFLATLASSSSEEM--ESQLQ 175
             T+  +L+  + + ++D +Q   E +D  +     E       T A+  +EE+  E    
Sbjct: 1723 HTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTS 1782

Query: 176  ERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQENMRLQEL 235
              +E  ++ + Q V       ++ E L+ K        +E  V+EL   +  E  R  E 
Sbjct: 1783 AHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEA 1842

Query: 236  TDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEV 295
               L+ KH    +E +      +T E R ++L      LQ  +DK++ + +   R   E 
Sbjct: 1843 VKGLR-KHERRVKELT-----YQTEEDRKNILR-----LQDLVDKLQAKVKSYKRQAEEA 1891

Query: 296  LERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDFEE 355
             E+ N+                   N  KF ++  ELEE +E A     ++ KLR    E
Sbjct: 1892 EEQSNT-------------------NLAKFRKLQHELEEAEERADIAESQVNKLRVKSRE 1932

Query: 356  VTTQ 359
            V T+
Sbjct: 1933 VHTK 1936


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score =  122 bits (305), Expect = 2e-27
 Identities = 206/924 (22%), Positives = 379/924 (41%), Gaps = 158/924 (17%)

Query: 51   LQTKNRKLAEMLDQRQAIEDELREHIEKLER-----RQATDDASLLI--VNRYWSQFDEN 103
            L+ K +++ E  +  + I  EL     KLE      ++  DD  L +  V +     +  
Sbjct: 916  LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 975

Query: 104  IRIILKRYD-LEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATL 162
            ++ + +    L++ +  L  E+KAL         +++Q+  DD +  E +          
Sbjct: 976  VKNLTEELSGLDETIAKLTREKKAL--------QEAHQQALDDLQAEEDKV--------- 1018

Query: 163  ASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELN 222
              +S  + +S+L+++VE    ++ Q      KL+  +E   RKL  GD  + +E++ +L 
Sbjct: 1019 --NSLNKTKSKLEQQVEDLESSLEQ----EKKLRVDLERNKRKLE-GDLKLAQESILDL- 1070

Query: 223  SFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIR 282
                 EN + Q     L E+ +    E+ +LQSKVE  ++     +  I +LQ  I+++ 
Sbjct: 1071 -----ENDKQQ-----LDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELE 1120

Query: 283  KREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEE-------N 335
            +  +      AE   R  ++  +             +  AR+ EE++  LEE        
Sbjct: 1121 EEIE------AERATRAKTEKQR-------------SDYARELEELSERLEEAGGVTSTQ 1161

Query: 336  KELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPE-YRCMQSQFSVLYNE 394
             EL + R  E  KLR+D EE T Q+E +   LR      V E  E    +Q     L  E
Sbjct: 1162 IELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1221

Query: 395  SLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVR-KEYE 453
              + K  +D+  +            +E + + + +L K  RT    LED L++ R K  E
Sbjct: 1222 KSEFKLEIDDLSS-----------SMESVSKSKANLEKICRT----LEDQLSEARGKNEE 1266

Query: 454  MLRIEFEQTLAANE---QAGPINREMRH---LISSLQNHNHQLKGEVLRYKRKLREAQSD 507
            + R   E T   +    +AG ++R++     ++S L         +    KR+L E    
Sbjct: 1267 IQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEE--- 1323

Query: 508  LNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQE----------DA 557
             NK +     AL  S+   +  +++  E +    +L  Q + SKA+ E          DA
Sbjct: 1324 -NKAKNALAHALQSSRHDCDLLREQYEEEQEGKAEL--QRALSKANSEVAQWRTKYETDA 1380

Query: 558  NEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDD 617
             +   + +E +++  +R ++ E + E    K    EK K +   +  D   D E+     
Sbjct: 1381 IQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLA 1440

Query: 618  GR--KKEAEIIKQLKIELKKAQESQKEMKLLLDMYRS----------APKEQRDKVQLMA 665
                KK+    K L     K +ESQ E++  L   RS          A +E  D+++ + 
Sbjct: 1441 AALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVK 1500

Query: 666  AEKKS-KAELEDLRQRL----KDLEDKEK--------KENKKMADEDALRKIRAVEEQIE 712
             E K+ + E+ DL +++    K + + EK        K + ++A E+A   +   E +I 
Sbjct: 1501 RENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKIL 1560

Query: 713  YLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIK--- 769
             +Q +L   K E +  ++E D   +  E ++    R ++ ++   DA  +  +E I+   
Sbjct: 1561 RIQLELTQVKSEIDRKIAEKD---EEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKK 1617

Query: 770  -----SNQIHKLLKEEKEELADQVLTLKT----------QVDAQLQVVRKLEEKEHLLQS 814
                  N+I   L     + A+ +  L++           +D  L+    L+E+  +++ 
Sbjct: 1618 KMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVER 1677

Query: 815  NIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEK 874
                 + E+      LE  +R    A Q   D   +++L    LH     ++      E 
Sbjct: 1678 RANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQL----LHTQNTSLIHTKKKLET 1733

Query: 875  DMFNFKRAQEDISRLRRKLETTKK 898
            D+   +   ED SR  R  E   K
Sbjct: 1734 DLMQLQSEVEDASRDARNAEEKAK 1757



 Score =  107 bits (266), Expect = 7e-23
 Identities = 177/807 (21%), Positives = 346/807 (42%), Gaps = 138/807 (17%)

Query: 57   KLAEMLDQRQAIEDELREHIEKLERRQATDD--ASLLIVNRYWSQFDENIRIIL------ 108
            +L E +D  Q ++ +L +  EK E +   DD  +S+  V++  +  ++  R +       
Sbjct: 1203 ELGEQIDNLQRVKQKLEK--EKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEA 1260

Query: 109  --KRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSS 166
              K  ++++ L +L T++  L     E  S   +E++    +    + AF+         
Sbjct: 1261 RGKNEEIQRSLSELTTQKSRLQTEAGEL-SRQLEEKESIVSQLSRSKQAFT-------QQ 1312

Query: 167  SEEMESQLQER----------VESSRRAVSQIVTVYDKLQE-KVELLSRKLNSGDNLIVE 215
            +EE++ QL+E           ++SSR     +   Y++ QE K EL             +
Sbjct: 1313 TEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAEL-------------Q 1359

Query: 216  EAVQELNSFLAQENMRLQ----ELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMI 271
             A+ + NS +AQ   + +    + T+ L+E  + ++Q     + +VE   ++ + LE   
Sbjct: 1360 RALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTK 1419

Query: 272  DDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAE 331
              LQ +++ +    +R N  LA  L++      KV     +           K EE  AE
Sbjct: 1420 QRLQGEVEDLMVDVERANS-LAAALDKKQRNFDKVLAEWKT-----------KCEESQAE 1467

Query: 332  LEENKELAQNRLCELEKLRQDFEE-------VTTQNEKLKVELRSAVEQVVKETPEYRCM 384
            LE + + +++   EL KL+  +EE       V  +N+ L+ E+    EQ+ +       +
Sbjct: 1468 LEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHEL 1527

Query: 385  QSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDT 444
            +     +  E   ++  L+EA   L       +H+   I R ++ L  ++++E+   +  
Sbjct: 1528 EKSRKQIELEKADIQLALEEAEAAL-------EHEEAKILRIQLEL-TQVKSEI---DRK 1576

Query: 445  LAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREA 504
            +A+  +E E L+  +++T+   + A  ++ E+R             + E +R K+K+   
Sbjct: 1577 IAEKDEEIEQLKRNYQRTVETMQSA--LDAEVRS------------RNEAIRLKKKM--- 1619

Query: 505  QSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKR 564
            + DLN+  ++   A  Q+  + +  +    +LK    D       +   QED   +K + 
Sbjct: 1620 EGDLNEIEIQLSHANRQAAETLKHLRSVQGQLK----DTQLHLDDALRGQED---LKEQL 1672

Query: 565  DEEERERERREKEREREREREKEKERERE--KQKLKESEKERDSAKDKEKGKHDDGRKKE 622
               ER     + E E  R   ++ ER R+  +Q+L +S +       +        +K E
Sbjct: 1673 AIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLE 1732

Query: 623  AEIIKQLKIELKKAQE-----SQKEMKLLLD---MYRSAPKEQRDKVQLMAAEKKSKAEL 674
             +++ QL+ E++ A        +K  K + D   M     KEQ     L   +K  +  +
Sbjct: 1733 TDLM-QLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTV 1791

Query: 675  EDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKK-----LAMAKQEEEALL 729
            +DL+ RL + E    K  KK   +   R IR +E ++E  QKK       + K E     
Sbjct: 1792 KDLQHRLDEAEQLALKGGKKQIQKLETR-IRELEFELEGEQKKNTESVKGLRKYERRV-- 1848

Query: 730  SEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVL 789
               ++T Q+ ED   +N+  +Q L +K       +  ++KS   +K   EE +E A+  L
Sbjct: 1849 --KELTYQSEED--RKNVLRLQDLVDK-------LQVKVKS---YKRQAEEADEQANAHL 1894

Query: 790  TLKTQVDAQLQVVRKLEEKEHLLQSNI 816
            T   +   +L+   + EE+  + +S +
Sbjct: 1895 TKFRKAQHELE---EAEERADIAESQV 1918



 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 99/467 (21%), Positives = 208/467 (44%), Gaps = 35/467 (7%)

Query: 446  AQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQ 505
            A+  KE   ++ EF++T     ++    +E+   + +L    + L+ +V      L +A+
Sbjct: 844  AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAE 903

Query: 506  S---DLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKS 562
                 L K + +  + + +     ED ++  AEL      L  + S  K   +D     +
Sbjct: 904  ERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 963

Query: 563  KRDEEERERERREKERERERE--REKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRK 620
            K ++E+   E + K    E     E   +  REK+ L+E+ ++       E+ K +   K
Sbjct: 964  KVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNK 1023

Query: 621  KEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQR 680
             ++++ +Q++ +L+ + E +K  KL +D+ R+  K + D      +    + + + L +R
Sbjct: 1024 TKSKLEQQVE-DLESSLEQEK--KLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDER 1080

Query: 681  LKDLEDKEKKENKKMADEDAL-----RKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVT 735
            LK  + +  +   K+ DE  L     +KI+ ++ +IE L++++   +        +    
Sbjct: 1081 LKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDY 1140

Query: 736  GQAFEDMQEQ-----NIRLMQ-QLREKDDANF-KLMSERIKSNQIHK-LLKEEKEELADQ 787
             +  E++ E+      +   Q +L +K +A F KL  +  ++   H+ ++   +++ AD 
Sbjct: 1141 ARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADS 1200

Query: 788  VLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDL 847
            V  L  Q+D   +V +KLE+++   +  I        L +    ++K KA    ++   L
Sbjct: 1201 VAELGEQIDNLQRVKQKLEKEKSEFKLEID------DLSSSMESVSKSKA-NLEKICRTL 1253

Query: 848  KAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLE 894
            + QL  A+ K  + Q  + E +  K        R Q +   L R+LE
Sbjct: 1254 EDQLSEARGKNEEIQRSLSELTTQK-------SRLQTEAGELSRQLE 1293



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 74/349 (21%), Positives = 156/349 (44%), Gaps = 58/349 (16%)

Query: 560  IKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHD--- 616
            +KS   E+E    + E ++ ++   + E +R+  ++KL    +E++  + + + + +   
Sbjct: 841  LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLL 900

Query: 617  DGRKKEAEIIK---QLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAE 673
            D  ++  ++IK   QL+ ++K+  E              A  E+    +L A ++K + E
Sbjct: 901  DAEERCDQLIKAKFQLEAKIKEVTE-------------RAEDEEEINAELTAKKRKLEDE 947

Query: 674  LEDLRQRLKDLE-DKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEM 732
              +L++ + DLE    K E +K A E+   K++ + E++  L + +A   +E++AL    
Sbjct: 948  CSELKKDIDDLELTLAKVEKEKHATEN---KVKNLTEELSGLDETIAKLTREKKAL---Q 1001

Query: 733  DVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLK 792
            +   QA +D+Q                     +E  K N ++K     K +L  QV  L+
Sbjct: 1002 EAHQQALDDLQ---------------------AEEDKVNSLNK----TKSKLEQQVEDLE 1036

Query: 793  TQVDAQLQVVRKLEEKEHLLQSNIGTGEKEL----GLRTQALEMNKRKAMEAAQLADDLK 848
            + ++ + ++   LE  +  L+ ++   ++ +      + Q  E  K+K  E  QL   ++
Sbjct: 1037 SSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVE 1096

Query: 849  AQLELA---QKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLE 894
             +  L    QKK+ + Q  I E     E +     + ++  S   R+LE
Sbjct: 1097 DEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELE 1145



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 82/476 (17%), Positives = 197/476 (41%), Gaps = 42/476 (8%)

Query: 168  EEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQ 227
            EE +++L+  ++ SR   +++  + +  +E ++ L        NL  E+ + +L   +A+
Sbjct: 1462 EESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNL--EQEIADLTEQIAE 1519

Query: 228  ENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQR 287
                + EL    ++  + +  E + +Q  +E AE+ +   E+ I  +Q ++ +++    R
Sbjct: 1520 NGKTIHEL----EKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDR 1575

Query: 288  LNRHLAEVLERVNSKGYKVYGAGSSLYGGTITIN---ARKFEEMNAELEENKELAQNRLC 344
                  E +E++     +      S     +       R  ++M  +L E +    +   
Sbjct: 1576 KIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANR 1635

Query: 345  ELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDE 404
            +  +  +    V  Q +  ++ L  A+        +   ++ + ++L  E  +L+A L++
Sbjct: 1636 QAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQ 1695

Query: 405  ---ARTLLHGTRGTHQHQVELIERDEVSL---HKKLRTEVIQL----EDTLAQVRKEYEM 454
               AR L          +V+L+     SL    KKL T+++QL    ED     R   E 
Sbjct: 1696 TERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEK 1755

Query: 455  LR-------IEFEQTLAANEQAGPINREMRHLISSLQNHNHQL-----------KGEVLR 496
             +       +  E+     + +  + R  ++L  ++++  H+L           K ++ +
Sbjct: 1756 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK 1815

Query: 497  YKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSED-LSSQSSASKASQE 555
             + ++RE + +L   + ++  ++   +      K+   + + D ++ L  Q    K   +
Sbjct: 1816 LETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVK 1875

Query: 556  DANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKE 611
                +KS + + E   E+      + R+ + E E   E+  + ES+  +  AK ++
Sbjct: 1876 ----VKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRD 1927



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 64/293 (21%), Positives = 113/293 (38%), Gaps = 45/293 (15%)

Query: 66   QAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDENIRIILKRYDLEQGLGDLLTERK 125
            QA  +ELR  +E+ ER +   +  LL         D N R+ L    L      L+  +K
Sbjct: 1683 QAEVEELRATLEQTERARKLAEQELL---------DSNERVQL----LHTQNTSLIHTKK 1729

Query: 126  ALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSSSEEMESQLQERVESSRRAV 185
             L     +  S+     +D R   E  + A +  A +A    +E ++     +E  ++ +
Sbjct: 1730 KLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAH--LERMKKNL 1787

Query: 186  SQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQEKHRT 245
             Q V       ++ E L+ K        +E  ++EL   L  E  +  E    L++  R 
Sbjct: 1788 EQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERR 1847

Query: 246  MSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYK 305
            + +         ++ E R +VL      LQ  +DK++ + +   R   E  E+ N+    
Sbjct: 1848 VKE------LTYQSEEDRKNVLR-----LQDLVDKLQVKVKSYKRQAEEADEQANA---- 1892

Query: 306  VYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDFEEVTT 358
                           +  KF +   ELEE +E A     ++ KLR    + T+
Sbjct: 1893 ---------------HLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTS 1930


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score =  121 bits (303), Expect = 4e-27
 Identities = 190/915 (20%), Positives = 405/915 (44%), Gaps = 121/915 (13%)

Query: 48   IRTL-QTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDENIRI 106
            +RT+ +  +R+  E+L+Q   +E+E R+ +E L+ R   ++ S+   +   +   E  RI
Sbjct: 413  LRTMVEAADREKVELLNQ---LEEEKRK-VEDLQFR--VEEESITKGDLEVATVSEKSRI 466

Query: 107  ILKRYDLEQGLGDLLTERKALVVPEPEPDSDSN----QERKDDRERGEGQEPAFSFLATL 162
            +    DL   + ++   R+ L   +P  D D +    QE    +E+ E          T 
Sbjct: 467  MELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLE-------VTRTD 519

Query: 163  ASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKL---NSGDNLIVEEAVQ 219
                   ++     R E+ ++ +  + T  +KL ++ E L  KL   N  ++ ++     
Sbjct: 520  HQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKS 579

Query: 220  ELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDID 279
            +L + +A     ++EL     +   T + EF++L++++E           M  D Q +I+
Sbjct: 580  KLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIE----------KMRLDYQHEIE 629

Query: 280  KIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEE--NK- 336
             ++ ++       A+ +E + +K  KV     +      +   +  ++   E+E+  NK 
Sbjct: 630  NLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKL 689

Query: 337  ELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESL 396
            + A+ ++ ELE L+    E T   +    +L++  E+++      +      S +     
Sbjct: 690  QEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQ 749

Query: 397  QLKA------HLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRK 450
            QL+A      HL+  +        +   +++  E    +L + L +EV Q+++TL    K
Sbjct: 750  QLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENL-SEVSQVKETL---EK 805

Query: 451  EYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNK 510
            E ++L+ +F +   A+E+A  + R M+  ++ L     Q                SDL K
Sbjct: 806  ELQILKEKFAE---ASEEAVSVQRSMQETVNKLHQKEEQFN-----------MLSSDLEK 851

Query: 511  TRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQ-SSASKASQEDANEIKSKRDE--- 566
              LR   A ++++   +D ++E  +L    E L +  +   K S ++++++    DE   
Sbjct: 852  --LRENLADMEAKFREKDEREE--QLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRL 907

Query: 567  EERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEII 626
            +ER+ E  + +  +  E     ++  E   +K  + ++++AK     KH++ +K+    +
Sbjct: 908  KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAK-----KHEEEKKELERKL 962

Query: 627  KQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKV------QLMAAEKKSKAELEDLRQR 680
              L+ +++ +    +E+K   +   S  K + +++       L+  E K K   E+    
Sbjct: 963  SDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGL 1022

Query: 681  LKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFE 740
            L++LE+  K+ +K  A + A   ++ +E+          M K++ E L S         E
Sbjct: 1023 LQELEELRKQADKAKAAQTAEDAMQIMEQ----------MTKEKTETLAS--------LE 1064

Query: 741  DMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQ 800
            D ++ N +L  +L    + N K + E  KS ++  +  ++ EE   ++ TLK     + Q
Sbjct: 1065 DTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQ 1124

Query: 801  VVRKLEEKEHLLQSNIGTGEKELG-----------LRTQALEMNKRKAMEAAQLADDLKA 849
             +  L+E+   L   +G    E+            L  Q LEM KR++ +  + AD+ KA
Sbjct: 1125 QLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRES-KFIKDADEEKA 1183

Query: 850  QLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKKPDNVP---KCD 906
             L   QK +       + +++  EKD    ++ + +++ LR +  + K   +V    + D
Sbjct: 1184 SL---QKSIS------ITSALLTEKDA-ELEKLRNEVTVLRGENASAKSLHSVVQTLESD 1233

Query: 907  EILME-EIKDYKARL 920
            ++ +E ++K+ + +L
Sbjct: 1234 KVKLELKVKNLELQL 1248



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 103/561 (18%), Positives = 220/561 (39%), Gaps = 90/561 (16%)

Query: 37   LGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQA-----TDDASLL 91
            L  VS  +E   + LQ    K AE  ++  +++  ++E + KL +++      + D   L
Sbjct: 793  LSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKL 852

Query: 92   IVN------RYWSQFDENIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDD 145
              N      ++  + +   ++I  +  LE  + +++         +   D+ S   + +D
Sbjct: 853  RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM---------KMSGDNSSQLTKMND 903

Query: 146  RER-GEGQEPAFSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDK----LQEKVE 200
              R  E          T A+ ++  ++  +++    + ++  +    +++    L+ K+ 
Sbjct: 904  ELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLS 963

Query: 201  LLSRKLNSGDNLIVE-----------------EAVQELNSFLAQENMRL----QELTDLL 239
             L +K+ +  N   E                 E +Q L   L     +L    +E + LL
Sbjct: 964  DLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLL 1023

Query: 240  QEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQ---RLNRHLAEVL 296
            QE      Q  +      +TAE  + ++E M  +    +  +   +Q   +L   L + L
Sbjct: 1024 QELEELRKQ--ADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNEL-DTL 1080

Query: 297  ERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQD---- 352
            +  N K  +       L    +T+  +K EE   E+E  K+ A  +  +L  L+++    
Sbjct: 1081 KENNLKNVEELNKSKEL----LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKL 1136

Query: 353  ------FEEVTTQNEKLK----------VELRSAVEQVVKETPEYRC-MQSQFSVLYNES 395
                    +  T ++KL+          +E++    + +K+  E +  +Q   S+     
Sbjct: 1137 AEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALL 1196

Query: 396  LQLKAHLDEAR---TLLHGTRGTHQHQ---VELIERDEVSLHKKLRTEVIQLEDTLAQVR 449
             +  A L++ R   T+L G   + +     V+ +E D+V L  K++   +QL++   Q+ 
Sbjct: 1197 TEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLS 1256

Query: 450  KEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLN 509
                    + ++   A E        +  +I  LQ  N  LK +V      + EA  + N
Sbjct: 1257 SSSGNTDTQADEDERAQESQIDF---LNSVIVDLQRKNQDLKMKV----EMMSEAALNGN 1309

Query: 510  KTRLRSGSALLQSQSSTEDPK 530
               L +  +  Q + S + P+
Sbjct: 1310 GDDLNNYDSDDQEKQSKKKPR 1330



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 91/453 (20%), Positives = 189/453 (41%), Gaps = 44/453 (9%)

Query: 491 KGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSAS 550
           K +    +R +    + L ++   S  + + S +S+   +     L  ++    ++  + 
Sbjct: 290 KAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISG 349

Query: 551 KASQEDANEIKSKRDEE---ERERERREKEREREREREKEKEREREKQKLKESEKERDSA 607
             + ++A + K +  E+   ER+ ER E  +      E E+E    +    +   E ++ 
Sbjct: 350 TTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAK 409

Query: 608 KDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAA- 666
            D+ +   +   +++ E++ QL+ E +K ++ Q  ++          +E   K  L  A 
Sbjct: 410 MDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVE----------EESITKGDLEVAT 459

Query: 667 --EKKSKAELE-DLRQRLKDLEDKEKK--ENKKMADEDALRKIRAVEEQIEYLQKKLAMA 721
             EK    ELE DL  R++++ +  ++   NK   D D    +    ++I  LQ+KL + 
Sbjct: 460 VSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLL---QEISSLQEKLEVT 516

Query: 722 KQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEK 781
           + + +  ++ +     A E+  ++ I+ +    EK        +E +KS   H   KE  
Sbjct: 517 RTDHQREITSLKEHFGAREETHQKEIKALYTATEK----LSKENESLKSKLEH-ANKENS 571

Query: 782 EELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELG-LRTQALEMNKRKAMEA 840
           + +A     L+T + +  Q    +EE +      +GT   E   L+TQ  +M      E 
Sbjct: 572 DVIALWKSKLETAIASHQQA---MEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEI 628

Query: 841 AQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKKPD 900
             L +   ++     K++   + ++++  V KEK        +  +  +R KL+  +   
Sbjct: 629 ENLQNQQDSERAAHAKEMEALRAKLMK--VIKEK--------ENSLEAIRSKLDKAEDQH 678

Query: 901 NVPKCDEI--LME-EIKDYKARLTCPCCNMRKK 930
            V   D +  L E EIK  +  +    CN + K
Sbjct: 679 LVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTK 711


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score =  121 bits (303), Expect = 4e-27
 Identities = 192/915 (20%), Positives = 387/915 (42%), Gaps = 154/915 (16%)

Query: 51   LQTKNRKLAEMLDQRQAIEDELREHIEKLERRQAT-----DDASLLI--VNRYWSQFDEN 103
            L+ K ++L E L++ + +  EL      LE + ++     DD  L +  V +     +  
Sbjct: 919  LEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENK 978

Query: 104  IRIILKRYD-LEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATL 162
            ++ + +    LE+ +  L  E+K+L         +++Q+  DD +  E +      +   
Sbjct: 979  VKNLSEEMTALEENISKLTKEKKSL--------QEAHQQTLDDLQVEEDKVNGLIKINAK 1030

Query: 163  ASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELN 222
                ++++E  L++                 KL+  +E   RKL  GD  + +E++ +L 
Sbjct: 1031 LEQQTDDLEGSLEQE---------------KKLRADLERAKRKLE-GDLKMSQESIMDL- 1073

Query: 223  SFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETA-------ESRVSVLESMIDDLQ 275
                 EN + Q     ++EK +    E S+LQ+K++         + ++  L++ I++L+
Sbjct: 1074 -----ENDKQQ-----IEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELE 1123

Query: 276  WDID-------KIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEM 328
             +I+       KI K+   L R L E+ ER+               G T           
Sbjct: 1124 EEIEAEHTLRAKIEKQRSDLARELEEISERLEEAS-----------GAT----------- 1161

Query: 329  NAELEENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPE-YRCMQSQ 387
            +A++E NK+    R  E +K+R+D EE T Q+E     LR      V E  E    +Q  
Sbjct: 1162 SAQIEMNKK----REAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRV 1217

Query: 388  FSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQ 447
               L  E  +LK  +D+  +            +E + + + ++ +  RT   Q  +  A+
Sbjct: 1218 KQKLEKEKSELKMEIDDMAS-----------NIEALSKSKSNIERTCRTVEDQFSEIKAK 1266

Query: 448  VRKEYEMLRIEFEQTLAANEQAGPIN---REMRHLISSLQNHNHQLKGEVLRYKRKLREA 504
              ++ +++     Q      Q G ++    E   LIS L      L  ++   KR++ E 
Sbjct: 1267 DEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEE 1326

Query: 505  QSDLNK-----TRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQE-DAN 558
                N         R    LL+ Q   E+ ++  AEL+      +S+ +  +   E DA 
Sbjct: 1327 TKAKNAMAHALQSSRHDCDLLREQ--YEEEQEAKAELQRALSKANSEVAQWRTKYETDAI 1384

Query: 559  EIKSKRDEEERERERREKEREREREREKEK--EREREKQKLKESEKE--RD--------S 606
            +   + +E +++  +R +E E   E    K    E+ KQ+L+   ++  RD        +
Sbjct: 1385 QRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACA 1444

Query: 607  AKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAA 666
              DK++   D    +  + + + + EL+ AQ+  + +   L   R+A +E  D+++ +  
Sbjct: 1445 TLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRR 1504

Query: 667  EKKS-KAELEDLRQRL----KDLEDKEKKENKKMADE---DALRKIRAVEEQIEYLQKKL 718
            E K+ + E+ DL +++    K+L++ EK   KK+ ++   D    +  VE  +E+ + K+
Sbjct: 1505 ENKNLQEEISDLTEQIAETGKNLQEAEK--TKKLVEQEKSDLQVALEEVEGSLEHEESKI 1562

Query: 719  AMAKQEEEALLSEMD----VTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIK----- 769
               + E   + SE+D       +  E ++  + R  + L+   DA  +  ++ ++     
Sbjct: 1563 LRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKM 1622

Query: 770  ---SNQIHKLLKEEKEELADQVLTLKT----QVDAQLQVVRKLEEKEHLLQSNIGTGEKE 822
                N++   L     ++A+    L+T      D+QL +   L   E  L+  +   E+ 
Sbjct: 1623 EGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNED-LKEQLAIVERR 1681

Query: 823  LGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRA 882
             GL  + LE       E     +  +    L++++L D  D  V+   ++   + N K+ 
Sbjct: 1682 NGLLLEELE-------EMKVALEQTERTRRLSEQELLDASDR-VQLLHSQNTSLINTKKK 1733

Query: 883  QE-DISRLRRKLETT 896
             E DI++ + ++E +
Sbjct: 1734 LEADIAQCQAEVENS 1748



 Score =  111 bits (277), Expect = 4e-24
 Identities = 172/820 (20%), Positives = 348/820 (42%), Gaps = 84/820 (10%)

Query: 31   TVETIKLGGVSSTEEL--DIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDA 88
            T  T++     S  EL   I  LQ   +KL +   + +   D++  +IE L + ++  + 
Sbjct: 1192 TAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIER 1251

Query: 89   SLLIVNRYWSQFDENIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRER 148
            +   V     QF E   I  K     Q + DL  ++  L     E              R
Sbjct: 1252 TCRTVE---DQFSE---IKAKDEQQTQLIHDLNMQKARLQTQNGELS-----------HR 1294

Query: 149  GEGQEPAFSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNS 208
             E +E   S L     + ++++E +L+ ++E   +A + +       +   +LL  +   
Sbjct: 1295 VEEKESLISQLTKSKQALTQQLE-ELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEE 1353

Query: 209  GDNLIVE--EAVQELNSFLAQENMRLQ----ELTDLLQEKHRTMSQEFSKLQSKVETAES 262
                  E   A+ + NS +AQ   + +    + T+ L+E  + ++Q   + +   ETA S
Sbjct: 1354 EQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANS 1413

Query: 263  RVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINA 322
            + + LE     LQ +++ + +  +R +   A  L++      KV                
Sbjct: 1414 KCASLEKTKQRLQGEVEDLMRDLERSHTACA-TLDKKQRNFDKVLAEWK----------- 1461

Query: 323  RKFEEMNAELEENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYR 382
            +K +E  AELE  ++ +++   EL K+R  +EEV  Q E L+ E ++  E++   T +  
Sbjct: 1462 QKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQI- 1520

Query: 383  CMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLE 442
               ++      E+ + K  +++ ++ L         QV L E +    H++ +   +QLE
Sbjct: 1521 ---AETGKNLQEAEKTKKLVEQEKSDL---------QVALEEVEGSLEHEESKILRVQLE 1568

Query: 443  DTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLR 502
              L+QV+ E +   IE ++ +   EQ    ++     + S+ +   + + + LR K+K+ 
Sbjct: 1569 --LSQVKSELDRKVIEKDEEI---EQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKM- 1622

Query: 503  EAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKS 562
              + DLN+  ++ G +  Q   + +  +    +LK     L     +++  +E    ++ 
Sbjct: 1623 --EGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVER 1680

Query: 563  KRD--EEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRK 620
            +     EE E  +   E+     R  E+E      +++    +  S  + +K    D  +
Sbjct: 1681 RNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQ 1740

Query: 621  KEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQR 680
             +AE+   ++      ++++K +     M     KEQ     L   +K  +  ++DL+ R
Sbjct: 1741 CQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHR 1800

Query: 681  LKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMA-KQEEEALLSEMDVTGQAF 739
            L + E    K  KK   +    ++R +E +++  QK+ A A K   +      ++T QA 
Sbjct: 1801 LDEAEQLALKGGKKQI-QKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAE 1859

Query: 740  EDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQL 799
            ED   +NI  +Q L +K       +  ++KS   +K   EE EE A+  L+   +V  +L
Sbjct: 1860 ED--HKNILRLQDLVDK-------LQAKVKS---YKRQAEEAEEQANTQLSRCRRVQHEL 1907

Query: 800  QVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAME 839
            +   +  E+  + +S +        LR ++ ++  +K  E
Sbjct: 1908 E---EAAERADIAESQVNK------LRAKSRDVGSQKMEE 1938



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 157/738 (21%), Positives = 327/738 (44%), Gaps = 96/738 (13%)

Query: 240  QEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERV 299
            +++  TM ++F + + ++  +E+R   LE  +  L  + + ++ + Q    +L +  ER 
Sbjct: 850  EKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERC 909

Query: 300  NS--KGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDFEEVT 357
                K   +  A        +T    + EEMN+EL   K   +++   L++   D E   
Sbjct: 910  EGLIKSKILLEAKVK----ELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTL 965

Query: 358  TQNEKLKVELRSAVEQVVKE-TPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTH 416
            T+ EK K     A E  VK  + E   ++   S L  E    K  L EA          H
Sbjct: 966  TKVEKEK----HATENKVKNLSEEMTALEENISKLTKE----KKSLQEA----------H 1007

Query: 417  QHQVE--LIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINR 474
            Q  ++   +E D+V+   K+  ++ Q  D L    ++ + LR + E+     E    +++
Sbjct: 1008 QQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQ 1067

Query: 475  EMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPA 534
            E    I  L+N   Q++ ++ + + +L + Q+ ++  ++ S    LQ Q   ++ +    
Sbjct: 1068 ES---IMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHS----LQFQKKIKELQARIE 1120

Query: 535  ELKPDSE-DLSSQSSASKASQEDANEIK--SKRDEEERERERREKEREREREREKEKERE 591
            EL+ + E + + ++   K   + A E++  S+R EE       + E  ++RE E +K R 
Sbjct: 1121 ELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMR- 1179

Query: 592  REKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLD--- 648
               + L+E+  + ++     + K  D   +  E I  L+   +K ++ + E+K+ +D   
Sbjct: 1180 ---RDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMA 1236

Query: 649  -----MYRSAPKEQRD--KVQLMAAEKKSKAE-----LEDLRQRLKDLEDKEKKENKKMA 696
                 + +S    +R    V+   +E K+K E     + DL  +   L+ +  + + ++ 
Sbjct: 1237 SNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVE 1296

Query: 697  DEDAL-----RKIRAVEEQIEYLQKKLAMAKQEEEALL-------SEMDVTGQAFEDMQE 744
            ++++L     +  +A+ +Q+E L++++    + + A+         + D+  + +E+ QE
Sbjct: 1297 EKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQE 1356

Query: 745  QNIRLMQQLREKDDANFKLMSERIK----SNQIHKLLKEEKEELADQVLTLKTQVDAQLQ 800
                L + L +   AN ++   R K    + Q  + L+E K++LA ++   +   +    
Sbjct: 1357 AKAELQRALSK---ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANS 1413

Query: 801  VVRKLEEKEHLLQSNIGTGEKEL-GLRTQALEMNKRK------AMEAAQLADDLKAQLEL 853
                LE+ +  LQ  +    ++L    T    ++K++        E  Q  D+ +A+LE 
Sbjct: 1414 KCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEA 1473

Query: 854  AQK----------KLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKL-ETTKKPDNV 902
            AQK          K+ +  +E+V+   T  ++    K  QE+IS L  ++ ET K     
Sbjct: 1474 AQKESRSLSTELFKMRNAYEEVVDQLETLRREN---KNLQEEISDLTEQIAETGKNLQEA 1530

Query: 903  PKCDEILMEEIKDYKARL 920
             K  +++ +E  D +  L
Sbjct: 1531 EKTKKLVEQEKSDLQVAL 1548



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 120/619 (19%), Positives = 258/619 (41%), Gaps = 92/619 (14%)

Query: 320  INARKFEEMNAELEENKELAQNRLCELEKLRQDFEE--VTTQNEKLKVELRSAVEQVVKE 377
            + + + E+  A ++E+ E  +  L   E  R++ EE  V+   EK  ++L     QV  E
Sbjct: 844  LKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQL-----QVQSE 898

Query: 378  TPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTE 437
            T      + +   L    + L+A + E                E +E +E  ++ +L  +
Sbjct: 899  TENLMDAEERCEGLIKSKILLEAKVKEL--------------TERLEEEE-EMNSELVAK 943

Query: 438  VIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRY 497
               LED  + ++++ + L +   +          + +E     + ++N + ++       
Sbjct: 944  KRNLEDKCSSLKRDIDDLELTLTK----------VEKEKHATENKVKNLSEEMTA----- 988

Query: 498  KRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDA 557
               L E  S L K +     A  Q+    +  +D+   L   +  L  Q+   + S E  
Sbjct: 989  ---LEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQE 1045

Query: 558  NEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDD 617
             ++++     + ER +R+ E + +  +E   + E +KQ+++E  K+++    + + K DD
Sbjct: 1046 KKLRA-----DLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDD 1100

Query: 618  GRKKEAEIIKQLKI------ELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAE---- 667
             +    +  K++K       EL++  E++  ++  ++  RS    + +++     E    
Sbjct: 1101 EQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGA 1160

Query: 668  --------KKSKAELEDLRQRLKDL----EDKEKKENKKMADEDALRKIRAVEEQIEYLQ 715
                    KK +AE + +R+ L++     E       KK AD      +  + EQI+ LQ
Sbjct: 1161 TSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADS-----VAELGEQIDNLQ 1215

Query: 716  KKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHK 775
            +     ++E+  L  E+D      E + +    + +  R  +D   ++ ++  +  Q+  
Sbjct: 1216 RVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIH 1275

Query: 776  LLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKR 835
             L  +K  L  Q            ++  ++EEKE L+ S +   ++ L   TQ LE  KR
Sbjct: 1276 DLNMQKARLQTQ----------NGELSHRVEEKESLI-SQLTKSKQAL---TQQLEELKR 1321

Query: 836  KAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLET 895
            +  E  +  + +   L+ ++      +++  E    K +      +A  ++++ R K ET
Sbjct: 1322 QMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYET 1381

Query: 896  TKKPDNVPKCDEILMEEIK 914
                D + + +E  +EE K
Sbjct: 1382 ----DAIQRTEE--LEEAK 1394


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  119 bits (298), Expect = 1e-26
 Identities = 167/830 (20%), Positives = 358/830 (43%), Gaps = 90/830 (10%)

Query: 45   ELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDENI 104
            E + R  Q K  +  E  ++   +E+E R   ++   +Q   +       R   Q +E  
Sbjct: 468  EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEER 527

Query: 105  RIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLAS 164
              + +R   EQ L     ER+  ++   E +    QER++ R + E +E     L     
Sbjct: 528  --LQQRLRSEQQLRREQEERREQLLKREE-EKRLEQERREQRLKREQEERRDQLLKREEE 584

Query: 165  SSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSF 224
               + ++ + +ER+E   +            +E+VE L ++      L  EE  +E    
Sbjct: 585  RRQQRLKREQEERLEQRLK------------REEVERLEQEERREQRLKREEPEEERR-- 630

Query: 225  LAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKR 284
              Q+ ++ +E  +  Q++ R   QE  + + K E  E R+         L+ + ++ R+ 
Sbjct: 631  --QQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLE------QRLKREHEEERRE 682

Query: 285  EQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFE-EMNAELEENKELAQNRL 343
            ++       +  ER+ S+                 I   +++ E  A+  ++K  ++ R 
Sbjct: 683  QELAEEEQEQARERIKSR-----------------IPKWQWQLESEADARQSKVYSRPRK 725

Query: 344  CELEKLRQDFEEVTTQNE---KLKVELRSAVEQVVKETPE---YRCMQSQFSVLYNESLQ 397
             E ++ RQ+ EE   + E   + + E R+  +Q  +E      ++    + S    + L 
Sbjct: 726  QEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLS 785

Query: 398  LKAHLDEARTL-LHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLR 456
             +  L E R   L       + Q  L E +E    ++ R E            +E E+  
Sbjct: 786  ARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRE------------REKELQF 833

Query: 457  IEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSG 516
            +E E+ L   E+A  +  E       LQ    + + +  R  +K R     L + R R  
Sbjct: 834  LEEEEQLQRRERAQQLQEEE----DGLQEDQERRRSQEQRRDQKWRW---QLEEERKRRR 886

Query: 517  SALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREK 576
              L    +  E  + E   L+ + E+L  +    +  QE   + + +   ++ E +   +
Sbjct: 887  HTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLRE 946

Query: 577  EREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKA 636
            ERE+ R +E+E++  ++K+  ++ E+      +K + +  + + +E E ++Q + +L + 
Sbjct: 947  EREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLRE 1006

Query: 637  QESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMA 696
            +  ++  +     YR   + Q+++ QL+  E++ K  L++  ++ ++ E+ +++E + + 
Sbjct: 1007 EREKRRRQEWERQYRKKDELQQEEEQLL-REEREKRRLQERERQYREEEELQQEEEQLLG 1065

Query: 697  DEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREK 756
            +E   R+ + +E Q     +K    +QEEE LL E     +  E  +E+  R  ++L+++
Sbjct: 1066 EERETRRRQELERQ----YRKEEELQQEEEQLLREEPEKRRRQE--RERQCREEEELQQE 1119

Query: 757  DDANFKLMSERIKSNQIHKLLKEEKE--ELADQVLTLKTQVDAQLQVVRKLEEKEHLLQS 814
            ++   +   E+ +  ++ +  +EE+E  +  +Q+L  + +   + ++ R+  E+E L Q 
Sbjct: 1120 EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQ- 1178

Query: 815  NIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDE 864
                 E+E  LR    E  KR+     Q  ++ + Q    QK+   ++DE
Sbjct: 1179 -----EEEQLLRE---EQEKRRQERERQYREEEELQ---RQKRKQRYRDE 1217



 Score =  115 bits (287), Expect = 3e-25
 Identities = 188/929 (20%), Positives = 388/929 (41%), Gaps = 93/929 (10%)

Query: 51   LQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDENIRIILKR 110
            L+ +  KL E   QRQ    E  E + KLER++           R   Q +E  +  L+R
Sbjct: 253  LRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL----------RRERQEEEQQQQRLRR 302

Query: 111  YDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSSSEEM 170
               EQ L      RK     + E   +  +ER++ +ER E QE        L     E  
Sbjct: 303  ---EQQL-----RRK-----QEEERREQQEERREQQERREQQEERRE--QQLRREQEERR 347

Query: 171  ESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQENM 230
            E QL+   E  RR         ++ +E+     ++L     L  E+ ++       ++ +
Sbjct: 348  EQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 407

Query: 231  R----LQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQ 286
            R    L+    L +E+     QE  + + K E       +     +   W      KRE+
Sbjct: 408  RREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDW-----LKREE 462

Query: 287  RLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCEL 346
               RH  E  ++   +  +                 R+   +  E EE +E  + R  +L
Sbjct: 463  ETERHEQERRKQQLKRDQE---------------EERRERWLKLEEEERREQQERREQQL 507

Query: 347  EKLRQDFEE--VTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDE 404
             + +++  E  +  Q E+ +++ R   EQ ++   E R  Q    +L  E    +  L++
Sbjct: 508  RREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ----LLKREE---EKRLEQ 560

Query: 405  ARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIE----FE 460
             R      R   + + +L++R+E    ++L+ E    E+ L Q  K  E+ R+E     E
Sbjct: 561  ERREQRLKREQEERRDQLLKREEERRQQRLKRE---QEERLEQRLKREEVERLEQEERRE 617

Query: 461  QTLAANEQAGPINREMRHLISSLQNHNHQLKGE--VLRYKRKLREAQSDLNKTRLRSGSA 518
            Q L   E      +++       +    QL+ E    R +R  RE + +  + RL+    
Sbjct: 618  QRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHE 677

Query: 519  LLQSQSSTEDPKDEPAELKPDSEDLSSQ---SSASKASQEDANEIKSKRDEEERERERRE 575
              + +    + + E A  +  S     Q    S + A Q        K++ + R +E+ E
Sbjct: 678  EERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEE 737

Query: 576  KEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKK---EAEIIKQLKIE 632
            K R RE E + ++E    +Q+ +E ++   + + + + K + GR++      + +Q + +
Sbjct: 738  KRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQ 797

Query: 633  LKKAQESQKEMKLLLD----MYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKE 688
            L+  +  Q+E + L +      R   + +R+K +L   E++ + +  +  Q+L++ ED  
Sbjct: 798  LRAEERQQREQRFLPEEEEKEQRRRQRREREK-ELQFLEEEEQLQRRERAQQLQEEEDGL 856

Query: 689  KKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIR 748
            +++ ++   ++  R+ +    Q+E  +K+       + AL  ++    Q  ++ +E+  R
Sbjct: 857  QEDQERRRSQEQ-RRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQR 915

Query: 749  LMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEK 808
              ++ R + +   +   E     +  +LL+EE+E+   Q      + + Q +  +KL++K
Sbjct: 916  EEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ------ERERQYRKDKKLQQK 969

Query: 809  EHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVEN 868
            E  L      GE+    R Q  E   R+  E  Q  + L  + E  +++  +++ +  + 
Sbjct: 970  EEQL-----LGEEPEKRRRQEREKKYREEEELQQEEEQLLRE-EREKRRRQEWERQYRKK 1023

Query: 869  SVTKEKDMFNFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDYKARLTCPCCNMR 928
               ++++     R + +  RL+ +    ++ + + + +E L+ E ++ + R        R
Sbjct: 1024 DELQQEEE-QLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELE-RQYR 1081

Query: 929  KKDAVLTKCFHVFCFECVKTRYDTRQRKC 957
            K++ +  +   +   E  K R   R+R+C
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERERQC 1110



 Score =  109 bits (273), Expect = 1e-23
 Identities = 126/616 (20%), Positives = 278/616 (45%), Gaps = 66/616 (10%)

Query: 323 RKFEEMNAELEENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYR 382
           R+FE  + +LEE  E  Q R  + ++  ++  E   Q+EK             +E  E R
Sbjct: 120 RRFEPRDRQLEE--EPGQRRRQKRQEQERELAEGEEQSEK-------------QERLEQR 164

Query: 383 CMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLE 442
             Q +   L+ +  + +   +E R      +    H+ E    +E    +  R E+++L 
Sbjct: 165 DRQRRDEELWRQRQEWQER-EERRAEEEQLQSCKGHETEEFPDEE----QLRRRELLELR 219

Query: 443 DTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLR 502
               + R+E +  R E +  +   E+     +E R   + L+    +L+ E  + +R+L+
Sbjct: 220 ---RKGREEKQQQRRERQDRVFQEEE----EKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272

Query: 503 EAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKS 562
           E +  L K   +      Q +   +       +L+   E+   +    +  Q++  E + 
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE 332

Query: 563 KRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKE 622
           +R E++  RE+ E+  ++ R  ++E+ RE++ ++ +E E+     + +++ + +   ++E
Sbjct: 333 ERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRRE 392

Query: 623 AEIIKQLKI----ELKKAQESQKEMKLLLD-MYRSAPKEQR--DKVQLMAAEKKSKAELE 675
            ++ ++ ++    +L++ Q+ ++E +L  +   R   +E+R   K +    E++ K E E
Sbjct: 393 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQE 452

Query: 676 DLRQRLKDLEDKEKKENKK--------MADEDALRKIRAVEEQIEYLQKKLAMAKQEEEA 727
           + R  LK  E+ E+ E ++          +E   R ++  EE+    Q++     + E+ 
Sbjct: 453 ERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQE 512

Query: 728 LLSEMDVTGQAFEDMQEQNIRLMQQL-REKDDANFKLM----SERIKSNQIHKLLKEEKE 782
              E  +  Q  E+  +Q +R  QQL RE+++   +L+     +R++  +  + LK E+E
Sbjct: 513 ERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQE 572

Query: 783 ELADQVL---------TLKTQVDAQLQVVRKLEEKEHLLQ-----SNIGTGEKELGLRTQ 828
           E  DQ+L          LK + + +L+   K EE E L Q       +   E E   R Q
Sbjct: 573 ERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQ 632

Query: 829 ALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISR 888
            L+  +++     QL  + + + E  Q+   + ++E +E  + +E +    +R +++++ 
Sbjct: 633 LLKSEEQEERRQQQLRREQQERRE--QRLKREEEEERLEQRLKREHEE---ERREQELAE 687

Query: 889 LRRKLETTKKPDNVPK 904
             ++    +    +PK
Sbjct: 688 EEQEQARERIKSRIPK 703



 Score =  103 bits (258), Expect = 6e-22
 Identities = 203/993 (20%), Positives = 403/993 (40%), Gaps = 158/993 (15%)

Query: 52   QTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDEN-------- 103
            Q   R+  E  ++R+  E EL+   E+   RQ  ++         W   +++        
Sbjct: 726  QEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLS 785

Query: 104  IRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLA 163
             R  L+     Q   +   +R+   +PE E   +  Q R+  RER    E    FL    
Sbjct: 786  ARPPLREQRERQLRAEERQQREQRFLPEEE---EKEQRRRQRRER----EKELQFLEEEE 838

Query: 164  SSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKV--ELLSRKLNSGDNLIVEEAVQEL 221
                 E   QLQE  +  +    +  +   +  +K   +L   +      L  + A+QE 
Sbjct: 839  QLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQ 898

Query: 222  NSFLAQENMRLQELTDLLQ----EKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWD 277
               L +E   LQE  + LQ    EK R   QE    + +    E    + E      + +
Sbjct: 899  ---LRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE 955

Query: 278  IDKIRKREQRLNRHLAEVL-----ERVNSKGYKVYGAGSSLYGGTITI------------ 320
             ++  +++++L +   ++L     +R   +  K Y     L      +            
Sbjct: 956  RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQE 1015

Query: 321  ---NARKFEEMNAELEE--NKELAQNRLCELEKLRQDFEEVTTQNEKL------------ 363
                 RK +E+  E E+   +E  + RL E E+  ++ EE+  + E+L            
Sbjct: 1016 WERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQE 1075

Query: 364  -------KVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTH 416
                   + EL+   EQ+++E PE R  Q +      E    +   +E + L        
Sbjct: 1076 LERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEE---ELQQEEEQLLREEREKRR 1132

Query: 417  QHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREM 476
            + ++E   R+E  + ++   E +  E+   + R+E E    E E+     EQ   + RE 
Sbjct: 1133 RQELERQYREEEEVQQE--EEQLLREEPEKRRRQELERQYREEEELQQEEEQ---LLREE 1187

Query: 477  RHLISSLQNHNHQLKGEVLRYKRKLR----EAQSDLN-------KTRLRSGSALLQSQSS 525
            +      +   ++ + E+ R KRK R    + +SDL        +  +R      + + +
Sbjct: 1188 QEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGREN 1247

Query: 526  TEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERRE---------K 576
             +  + E ++L+             + SQ+D   +  ++ E +RE+ERR          +
Sbjct: 1248 EQFRQLEDSQLR------------DRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPE 1295

Query: 577  EREREREREKE-KEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIE--L 633
            E + ERE +KE K R+R+ Q  +E +  R+  ++K + +  D + +E E + Q + E  L
Sbjct: 1296 EEQLEREEQKEAKRRDRKSQ--EEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPL 1353

Query: 634  KKAQESQKEMKLLLDMYRSAPK--EQRDKVQLMAAEKKSKAELEDLR------QRLKDLE 685
            ++ +  +K  +  L       K  E+  +++    E+K   E + LR      Q  +D +
Sbjct: 1354 RRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRD 1413

Query: 686  DKEKKENKKMADEDALRKIRAVEEQI-------EYLQKKLAMAKQ------EEEALLSEM 732
             K ++E ++++ ++  RK R  E+Q+       ++L+++  + ++      EEE LL E 
Sbjct: 1414 RKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQER 1473

Query: 733  DVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLK 792
            +      ++   + +   QQLR + + + K   + ++S +  +   EE+++L  Q    K
Sbjct: 1474 EEQQLHRQERDRKFLEEEQQLR-RQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRK 1532

Query: 793  -TQVDAQLQVV-----------RKLEEKEHLLQ----SNIGTGEKELGLRTQALEMNK-- 834
              Q + QL+             RK  E+E L Q      +   E++   R +  ++ +  
Sbjct: 1533 FLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQE 1592

Query: 835  --RKAMEAAQLADDLKAQLELAQKKLHDFQD------EIVENSVTKEKDMFNFKRAQEDI 886
              RK ME  Q     + Q +L Q++   F++      E  E  + +++    F   +  +
Sbjct: 1593 QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQL 1652

Query: 887  SRLRRKLETTKKPDNVPKCDEILMEEIKDYKAR 919
             R  R+ +     D   + +E L++E ++ + R
Sbjct: 1653 RRQEREQQLRHDRDRKFREEEQLLQEGEEQQLR 1685



 Score =  101 bits (251), Expect = 4e-21
 Identities = 188/883 (21%), Positives = 365/883 (41%), Gaps = 106/883 (12%)

Query: 43   TEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDE 102
            +EE + R  Q   R+  E  +QR   E+E     ++L+R    +     +      Q  E
Sbjct: 636  SEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARE 695

Query: 103  NIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATL 162
             I+  + ++  +        + K    P  +      QE+++ R R E +          
Sbjct: 696  RIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESE---------- 745

Query: 163  ASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDN----LIVEEAV 218
                 EE  +  Q++ E  RR  +      +K +   + LS +    +     L  EE  
Sbjct: 746  -LQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQ 804

Query: 219  QELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDI 278
            Q    FL +E  + Q      Q + R    +F + + +++  E R   L+   D LQ D 
Sbjct: 805  QREQRFLPEEEEKEQRRR---QRREREKELQFLEEEEQLQRRE-RAQQLQEEEDGLQEDQ 860

Query: 279  DKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKEL 338
            ++ R +EQR ++     LE    +      A  +L         RK +++   L+E +E 
Sbjct: 861  ERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQE-----QLRKEQQL---LQEEEEE 912

Query: 339  AQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQL 398
             Q    E EK R+  +E   + E+   +L+   EQ+++E  E R  Q +    Y +  +L
Sbjct: 913  LQRE--EREKRRRQEQERQYREEE---QLQQEEEQLLREEREKRRRQER-ERQYRKDKKL 966

Query: 399  KAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIE 458
            +                 Q + +L+  +     ++ R +  + E+ L Q  +E ++LR E
Sbjct: 967  Q-----------------QKEEQLLGEEPEKRRRQEREKKYREEEELQQ--EEEQLLREE 1007

Query: 459  FEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSA 518
             E+      +     R+ R     LQ    QL  E  R KR+L+E +    +        
Sbjct: 1008 REKRRRQEWE-----RQYRKK-DELQQEEEQLLREE-REKRRLQERERQYREEE------ 1054

Query: 519  LLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKER 578
              + Q   E    E  E +   E L  Q    +  Q++  ++  +  E+ R +ER  + R
Sbjct: 1055 --ELQQEEEQLLGEERETRRRQE-LERQYRKEEELQQEEEQLLREEPEKRRRQERERQCR 1111

Query: 579  EREREREKEKE---REREKQKLKESE---KERDSAKDKEKG--KHDDGRKKEAEIIKQLK 630
            E E  +++E++    EREK++ +E E   +E +  + +E+   + +  +++  E+ +Q +
Sbjct: 1112 EEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYR 1171

Query: 631  IELKKAQESQKEMKLLLDMYRSAPKEQ-RDKVQLMAAEKKSKAELEDLRQRLKDLEDKEK 689
             E +  QE ++ ++   +  R   + Q R++ +L   ++K +   ED R  LK   + EK
Sbjct: 1172 EEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEK 1231

Query: 690  KENKKMADEDALRKIRAVEE--QIEYLQKKLAMAKQEEEALLSEMDVTGQAFE----DMQ 743
            +    + D     K R  E+  Q+E  Q +   ++Q+ + LL E     +  E      +
Sbjct: 1232 E--NAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQR 1289

Query: 744  EQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEEL------------ADQVLTL 791
            +++    +QL  ++    K      KS +  +LL+EE+EE              +Q+L  
Sbjct: 1290 DRHFPEEEQLEREEQKEAKRRDR--KSQEEKQLLREEREEKRRRQETDRKFREEEQLLQE 1347

Query: 792  KTQVDAQLQVVRKLEEKEHLLQSNIGTG--EKELGLRTQALEMNKRKAMEAAQLADDLKA 849
            + +   + Q   +   +E L     G    E+E  LR Q  E   RK ++  Q     + 
Sbjct: 1348 REEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERE---RKFLKEEQQLRCQER 1404

Query: 850  QLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRK 892
            + +L Q +   F++E  E  +++++    F+  ++ + R  R+
Sbjct: 1405 EQQLRQDRDRKFREE--EQQLSRQERDRKFREEEQQVRRQERE 1445



 Score =  100 bits (248), Expect = 9e-21
 Identities = 200/950 (21%), Positives = 382/950 (40%), Gaps = 131/950 (13%)

Query: 44   EELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQ-----------ATDDASLLI 92
            EE + R  Q + +K  E  + +Q  E  LRE  EK  R++             ++  LL 
Sbjct: 976  EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLR 1035

Query: 93   VNRYWSQFDENIRIILKRYDLEQGLGDLL-TERKALVVPEPEPDSDSNQERKDDRERGEG 151
              R   +  E  R   +  +L+Q    LL  ER+     E E      +E + + E+   
Sbjct: 1036 EEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLR 1095

Query: 152  QEPAFSFLATLASSSSEEMESQLQE----RVESSRRAVSQIVTVY----DKLQEKVELLS 203
            +EP             EE E Q +E    R E  +R   ++   Y    +  QE+ +LL 
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR 1155

Query: 204  RKLNSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESR 263
             +        +E   +E      +E   L+E  +  +++     +E  +LQ +      R
Sbjct: 1156 EEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYR 1215

Query: 264  VSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINAR 323
                E    DL+W  +  ++   R N               KVY  G            R
Sbjct: 1216 D---EDQRSDLKWQWEPEKENAVRDN---------------KVYCKGRE------NEQFR 1251

Query: 324  KFEEMNAELEENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRC 383
            + E+      ++++  Q+ L E ++  ++ E    Q           +E+  ++  + R 
Sbjct: 1252 QLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRD 1311

Query: 384  MQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHK-----KLRTEV 438
             +SQ      E   L+   +E R      R   + +  L ER+E  L +     K R E 
Sbjct: 1312 RKSQ-----EEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEE 1366

Query: 439  IQ--------LEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLIS------SLQ 484
            ++        LE+     R+E E   ++ EQ L   E+   + ++            S Q
Sbjct: 1367 LRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQ 1426

Query: 485  NHNHQLKGEVLRYKRKLREA-----QSDLNKTR---LRSGSALLQSQSSTE------DPK 530
              + + + E  + +R+ RE      +  L + R    R    LLQ +   +      D K
Sbjct: 1427 ERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRK 1486

Query: 531  --DEPAELKPDSED-------LSSQSSASKASQEDANEIKSKR------DEEERERERRE 575
              +E  +L+    D       L SQ    K  +E+    + +R      +E++  R+ R 
Sbjct: 1487 FLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERG 1546

Query: 576  KERERERER----EKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKI 631
            ++R ++R+R    E++  +ERE+Q+L   E++R    +++K +  +  +K  E  +QL  
Sbjct: 1547 QQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQL-- 1604

Query: 632  ELKKAQESQKEMKLLLD-MYRSAPK--EQRDKVQLMAAEKKSK-------AELEDLRQRL 681
               + QE Q++++   D  +R   +  ++R++ QL   E+  K          ++  Q+L
Sbjct: 1605 ---RRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL 1661

Query: 682  KDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEA--LLSEMDVTGQAF 739
            +   D++ +E +++  E   +++R  E   ++ +++  + +QE E   L  E  +  Q  
Sbjct: 1662 RHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQEL 1721

Query: 740  EDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEE--LADQVLTLKTQVDA 797
                E+  R  +QLR++ +       ER +     + L+ E+EE  L  Q    K + + 
Sbjct: 1722 ----ERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEE 1777

Query: 798  QLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLA-DDLKAQLELAQK 856
            QL+  R  EE++   Q +     +E  LR +  E   R      +   ++ + QLE  ++
Sbjct: 1778 QLRQER--EEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQ 1835

Query: 857  KL---HDFQDEIVENSVTKEKDMFNFKRA-QEDISRLRRKLETTKKPDNV 902
            +L    D Q    E   T+EK     +   QE+  + R++ E   + +++
Sbjct: 1836 RLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHI 1885



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 151/773 (19%), Positives = 317/773 (41%), Gaps = 102/773 (13%)

Query: 44   EELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDEN 103
            EE +++  + K R   E  DQR  ++ +        E+  A  D  +    R   QF + 
Sbjct: 1201 EEEELQRQKRKQRYRDE--DQRSDLKWQWEP-----EKENAVRDNKVYCKGRENEQFRQL 1253

Query: 104  IRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLA 163
                L+    +Q L  LL E+               QER  ++ER   Q+    F     
Sbjct: 1254 EDSQLRDRQSQQDLQHLLGEQ---------------QERDREQERRRWQQRDRHFPEEEQ 1298

Query: 164  SSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNS 223
                E+ E++ ++R     +   Q++    + + + +   RK    + L+ E   Q L  
Sbjct: 1299 LEREEQKEAKRRDRKSQEEK---QLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRR 1355

Query: 224  FLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETA----ESRVSVLESMIDDLQWDID 279
                   R +EL    QE+ R   +E  +L+ +        E +    +     L+ D D
Sbjct: 1356 QERDRKFREEELRH--QEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRD 1413

Query: 280  -KIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKEL 338
             K R+ EQ+L+R   +                            RKF E   ++   +E 
Sbjct: 1414 RKFREEEQQLSRQERD----------------------------RKFREEEQQVRR-QER 1444

Query: 339  AQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQL 398
             +  L E ++LRQ+      ++ K + E     EQ+++E  E +  + +    + E  Q 
Sbjct: 1445 ERKFLEEEQQLRQE------RHRKFREE-----EQLLQEREEQQLHRQERDRKFLEEEQQ 1493

Query: 399  KAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIE 458
                +  R        + + + + +E +E  LH++ R      E+   + ++  +  R +
Sbjct: 1494 LRRQERDRKFREQELRSQEPERKFLE-EEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQD 1552

Query: 459  FEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSA 518
             ++     EQ     RE + L    ++   +L+ + +R + + R+   D  + R + G  
Sbjct: 1553 RDRKFREEEQLRQ-EREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQ 1611

Query: 519  LLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEE---ERERERRE 575
             L+ +   +  +DE    + + + L  Q    K  +E+    + +R+++   +R+R+ RE
Sbjct: 1612 QLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFRE 1671

Query: 576  KEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKK 635
            +E+  +   E++  R+   +K +E E++    + + K   ++ + +  E+ ++ + E + 
Sbjct: 1672 EEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQL 1731

Query: 636  AQESQKEMKLLLDMYRSAPKEQ-----RDKVQLMAAEKKSK-AELEDLRQRLKDLEDKEK 689
             QE+++E     + YR   +E+     R++ QL   E+  K  E E LRQ  ++ + + +
Sbjct: 1732 RQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQ 1791

Query: 690  KENKKMADEDALR---------------KIRAVEEQIEYLQKKLAMAKQEEEALLSEMDV 734
            + ++K  +E+ LR               K R  EEQ++  +++  + ++ +    +E   
Sbjct: 1792 ESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQF 1851

Query: 735  TGQAFEDMQEQNIRLMQQLREKDDANFKLMSERI----KSNQIHKLLKEEKEE 783
              Q     +EQ +   ++ + + +   KL  E I    K  Q H+ + E K +
Sbjct: 1852 ATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQ 1904



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 162/749 (21%), Positives = 308/749 (41%), Gaps = 123/749 (16%)

Query: 51   LQTKNRKLAEMLDQRQAIEDEL-REHIEKLERRQATDDASLLIVNRYWSQFDENIRIILK 109
            L+ + +K A+  D++   E +L RE  E+  RRQ TD            +F E  +++ +
Sbjct: 1299 LEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETD-----------RKFREEEQLLQE 1347

Query: 110  RYDLEQGLGDLLTERKALVVPEPEPDSDSNQERK--DDRERGEGQEPAFSFLATLASSSS 167
            R   EQ L     +RK       E      Q RK  ++ +R   QE    FL        
Sbjct: 1348 RE--EQPLRRQERDRKF----REEELRHQEQGRKFLEEEQRLRRQERERKFL-------K 1394

Query: 168  EEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQ 227
            EE + + QER +  R+   +      K +E+ + LSR+    D    EE  Q       +
Sbjct: 1395 EEQQLRCQEREQQLRQDRDR------KFREEEQQLSRQ--ERDRKFREEEQQVRRQ--ER 1444

Query: 228  ENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQR 287
            E   L+E   L QE+HR   +E   LQ + E    R       +++ Q      + R Q 
Sbjct: 1445 ERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQ------QLRRQE 1498

Query: 288  LNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNR----- 342
             +R   E   R      K       L+        RKF +   +L   +   Q R     
Sbjct: 1499 RDRKFREQELRSQEPERKFLEEEQQLHRQQ---RQRKFLQEEQQLRRQERGQQRRQDRDR 1555

Query: 343  -LCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAH 401
               E E+LRQ+ EE     ++   + R   ++V ++  E + M+ +  +   E  Q    
Sbjct: 1556 KFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQ---Q 1612

Query: 402  LDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQ 461
            L + R      R   + +  L ER+E  LH++ R            + +E ++ R E EQ
Sbjct: 1613 LRQERD-----RKFREDEQLLQEREEQQLHRQERDRKF--------LEEEPQLRRQEREQ 1659

Query: 462  TLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQ 521
             L  +      +R+ R     LQ    Q      R  RK RE +  L +           
Sbjct: 1660 QLRHDR-----DRKFREEEQLLQEGEEQQLRRQER-DRKFREEEQQLRR----------- 1702

Query: 522  SQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERERE 581
                    ++   +   + + L  Q    K  +E+       R E E+E+ RR+ ER R+
Sbjct: 1703 --------QERERKFLQEEQQLRRQELERKFREEE-----QLRQETEQEQLRRQ-ERYRK 1748

Query: 582  REREKEKEREREKQKLKESEKERDSAKDKE-KGKHDDGRKKEAEIIKQLKIELKKAQESQ 640
               E++   ERE+Q+L+  E++R   ++++ + + ++ + +  E  ++ + E +  QE +
Sbjct: 1749 ILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQERE 1808

Query: 641  KEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDA 700
            ++        +  P+++  K +     ++ + +LE+  QRL+   D++ +  ++ A ++ 
Sbjct: 1809 EQ--------QLRPQQRDGKYRW----EEEQLQLEEQEQRLRQERDRQYRAEEQFATQEK 1856

Query: 701  LRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREK---- 756
             R+     E+ E  Q++    +QE E  L E  +  Q  E+ + + +  ++    K    
Sbjct: 1857 SRR-----EEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGR 1911

Query: 757  --DDANFKLMSERIKSNQIHKLLKEEKEE 783
              +    +  S  ++S+ +++ ++E++ +
Sbjct: 1912 LLEPGTHQFASVPVRSSPLYEYIQEQRSQ 1940



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 91/418 (21%), Positives = 199/418 (47%), Gaps = 22/418 (5%)

Query: 510 KTRLRSGSALLQSQSSTEDPKD-EPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEE 568
           + R     +LLQ +   ED +  EP + + + E    +    +  + +  E + + +++E
Sbjct: 100 RARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQE 159

Query: 569 RERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQ 628
           R  +R  + R+ E  R++++ +ERE+++ +E + +  S K  E  +  D  +     + +
Sbjct: 160 RLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQ--SCKGHETEEFPDEEQLRRRELLE 217

Query: 629 LKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKE 688
           L+ + ++ ++ Q+  +          KE R +  ++  E++   E E  RQR    E +E
Sbjct: 218 LRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQR----ELQE 273

Query: 689 KKENKKMADEDALRKIRAVEEQIEY-LQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNI 747
           ++E  +  +   LR+ R  EEQ +  L+++  + +++EE    + +   +  E  ++Q  
Sbjct: 274 EEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEE 333

Query: 748 RLMQQLR--EKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQV--DAQLQVVR 803
           R  QQLR  +++    +L  E+ +  +  +L +E++EE  +Q L  + Q+  + QL+  +
Sbjct: 334 RREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQ 393

Query: 804 KLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQD 863
           +L  ++ L +      E++L  R Q L   ++   E  +   + K + E  +++L   Q+
Sbjct: 394 QLRREQQLRREQQLRREQQL-RREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQE 452

Query: 864 E----IVENSVT----KEKDMFNFKRAQEDISRLR-RKLETTKKPDNVPKCDEILMEE 912
           E    +     T    +E+     KR QE+  R R  KLE  ++ +   + ++ L  E
Sbjct: 453 ERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRRE 510



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 81/398 (20%), Positives = 186/398 (46%), Gaps = 26/398 (6%)

Query: 541 EDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKES 600
           E+  ++    ++  +D  + + +R  E R+R+  E+  +R R++ +E+ERE  + + +  
Sbjct: 97  EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE 156

Query: 601 EKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDK 660
           ++ER   +D+++   +  R+++    +  + E ++A+E Q +     +      +EQ  +
Sbjct: 157 KQERLEQRDRQRRDEELWRQRQ----EWQEREERRAEEEQLQSCKGHETEEFPDEEQLRR 212

Query: 661 VQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAM 720
            +L+   +K + E +  R+  +D   +E++E +    E  LRK    EE+++  + +   
Sbjct: 213 RELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRK---EEEKLQEEEPQRQR 269

Query: 721 AKQEEEALLSEMD----VTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHK- 775
             QEEE  L +++       +  E+ Q+Q +R  QQLR K +   +   E  +  Q  + 
Sbjct: 270 ELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERRE 329

Query: 776 --------LLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGE--KELGL 825
                    L+ E+EE  +Q L  + + + + Q +R+ +E+E   Q      +  +E  L
Sbjct: 330 QQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQL 389

Query: 826 RTQALEMNKRKAMEAAQLADD----LKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKR 881
           R +     +++     QL  +     + QL   Q+   + ++E  E    +E+     KR
Sbjct: 390 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKR 449

Query: 882 AQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDYKAR 919
            QE+     ++ E T++ +   +  ++  ++ ++ + R
Sbjct: 450 EQEERRDWLKREEETERHEQERRKQQLKRDQEEERRER 487


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  119 bits (297), Expect = 2e-26
 Identities = 201/1010 (19%), Positives = 411/1010 (40%), Gaps = 147/1010 (14%)

Query: 20   EKKAAVEDSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAI---EDELREHI 76
            EK+ A E+  T +ET++   ++   +L    LQ +    AE  + R  +   + EL E  
Sbjct: 859  EKQLAAENRLTEMETLQSQLMAEKLQLQ-EQLQAETELCAEAEELRARLTAKKQELEEIC 917

Query: 77   EKLERRQATDDASLLIVNRYWSQFDENIRIILKRYDLEQG------LGDLLTERKALVVP 130
              LE R   ++     +     +  +NI+ + ++ + E+       L  + TE K   + 
Sbjct: 918  HDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLE 977

Query: 131  EPEPD-SDSNQERKDDRERGEGQEPAFSFLATLASSSSEEMESQLQERVESSRRAVSQIV 189
            E +    D N +   +++  E +   F+   T     S+ + ++L+ + E+    + + +
Sbjct: 978  EEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSL-AKLKNKHEAMITDLEERL 1036

Query: 190  TVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQEKHRTMSQE 249
               +K ++++E   RKL  GD+  + + + EL + +A+  M+L +  + LQ     + +E
Sbjct: 1037 RREEKQRQELEKTRRKLE-GDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEE 1095

Query: 250  FSKLQSKVETAESRVSVLESMIDDLQWDIDK---IRKREQRLNRHLAEVLERVNSKGYKV 306
                 ++   A  ++  LES I +LQ D++     R + ++  R L E LE + ++    
Sbjct: 1096 ----AAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDT 1151

Query: 307  YGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQ-------DFEEVTTQ 359
              + ++       + +++ +E+N   +  +E A+    +++++RQ       +  E   Q
Sbjct: 1152 LDSTAAQQ----ELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQ 1207

Query: 360  NEKLKVELRSAVEQVVKETPEY---------------------RCMQSQFSVLYNESLQL 398
             +++K  L  A + +  E  E                           +  V +NE  ++
Sbjct: 1208 TKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERV 1267

Query: 399  KAHLDEARTLLH-------GTRGTHQHQVELIERDEVSLHKKLRT----------EVIQL 441
            +  L +  T L        G       +   + +D  +L  +L+           + + L
Sbjct: 1268 RTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSL 1327

Query: 442  EDTLAQVRKEYEMLRIEFE-----------QTLAANEQAGPINREMRHLISSLQNHNH-- 488
               L QV  E    R + E           Q    + Q   + ++M   +  L+      
Sbjct: 1328 STKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVK 1387

Query: 489  -----QLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDL 543
                  L+G   R++ K+  A   L KT+ R    L       +  +     L+   +  
Sbjct: 1388 RKLQKDLEGLSQRHEEKVA-AYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKF 1446

Query: 544  SSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREKEKERERE---KQKLKES 600
                +  K       E + + + E RE+E +     R  E   E++ E E   KQ   E 
Sbjct: 1447 DQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEM 1506

Query: 601  EKERDSAKDKEKGKHDDGRKKEA--EIIKQLKIELKKAQE---SQKEMKLLLDMYRSAPK 655
            E    S  D  K  H+  + K A  + ++++K +L++ ++   + ++ KL L++   A K
Sbjct: 1507 EDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMK 1566

Query: 656  EQ-------RD------KVQLMAAEKKSKAELEDLRQR--------------LKDLEDKE 688
             Q       RD      K QL+   ++ +AELED R++              LKDLE   
Sbjct: 1567 AQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHI 1626

Query: 689  KKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIR 748
               NK    ++A++++R ++ Q++   ++L   +   E +L++     +  + M+ + I+
Sbjct: 1627 DSANKNR--DEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQ 1684

Query: 749  LMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEK 808
            L ++L           +ER K     +  ++E++ELAD++     +    L+  R+LE +
Sbjct: 1685 LQEELAA---------AERAK-----RQAQQERDELADEIANSSGKGALALEEKRRLEAR 1730

Query: 809  EHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVEN 868
               L+  +   E+E G      +  K+  ++  Q+  DL  +   AQK  +  Q    +N
Sbjct: 1731 IAQLEEEL---EEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQN 1787

Query: 869  SVTKEKDMFNFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDYKA 918
               K K      +  E   + + K   T     + + +E L  E K+ +A
Sbjct: 1788 KELKVK-----LQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQA 1832



 Score =  100 bits (250), Expect = 5e-21
 Identities = 157/828 (18%), Positives = 361/828 (43%), Gaps = 90/828 (10%)

Query: 27   DSGTTVETIKLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKL-ERRQAT 85
            D G  +E +K   +  T +      + ++++  E+   ++ +E+E + H  ++ E RQ  
Sbjct: 1136 DLGEELEALKTE-LEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKH 1194

Query: 86   DDASLLIVNRYWSQFDENIRIILK----RYDLEQGLGDLLTERKALVVPEPEPDSDSNQE 141
              A    V     Q ++  R+       +  LE   G+L  E K L+    +   DS  +
Sbjct: 1195 SQA----VEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLL----QGKGDSEHK 1246

Query: 142  RKDDRERGEGQEPAFSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVEL 201
            RK    + +  +  F+    + +  ++++ ++LQ  +++    +SQ  +   KL +    
Sbjct: 1247 RKKVEAQLQELQVKFNEGERVRTELADKV-TKLQVELDNVTGLLSQSDSKSSKLTKDFSA 1305

Query: 202  LSRKLNSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAE 261
            L  +L     L+ EE  Q+L+  L+ +  ++++  +  +E+     +    L+ ++ T  
Sbjct: 1306 LESQLQDTQELLQEENRQKLS--LSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLH 1363

Query: 262  SRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITIN 321
            ++V+ ++  ++D    ++   + +++L + L  + +R   K      A       T T  
Sbjct: 1364 AQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKV-----AAYDKLEKTKTRL 1418

Query: 322  ARKFEEMNAELEENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEY 381
             ++ +++  +L+  ++ A    C LEK ++ F+++  + + +  +     ++   E  E 
Sbjct: 1419 QQELDDLLVDLDHQRQSA----CNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK 1474

Query: 382  RCMQSQFSVLYNESLQLKAHLD----EARTLLHGTR------GTHQHQVELIERDEVSLH 431
                   +    E+++ KA L+    + RT +          G   H++E  +R      
Sbjct: 1475 ETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQV 1534

Query: 432  KKLRTEVIQLEDTL-----AQVRKEYEM--LRIEFEQTLA-----ANEQAGPINREMRHL 479
            ++++T++ +LED L     A++R E  +  ++ +FE+ L      + E+   + R++R +
Sbjct: 1535 EEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREM 1594

Query: 480  ISSLQNHNHQLKGEVLRYKRKLREAQSDL-------NKTRLRSGSALLQSQSSTEDPKDE 532
             + L++   Q +   +  ++KL     DL       NK R  +   L + Q+  +D   E
Sbjct: 1595 EAELEDERKQ-RSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRE 1653

Query: 533  PAELKPDSEDLSSQSSAS--KASQEDANEIKSKRDEEERERERREKEREREREREKEKER 590
              + +   E++ +Q+  +  K    +A  I+ + +    ER +R+ ++ER+ E   E   
Sbjct: 1654 LDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERD-ELADEIAN 1712

Query: 591  EREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMY 650
               K  L   EK R  A+  +  +  +  +   E+I      LKKA     ++   L++ 
Sbjct: 1713 SSGKGALALEEKRRLEARIAQLEEELEEEQGNTELIND---RLKKANLQIDQINTDLNLE 1769

Query: 651  RS-APKEQRDKVQLMAAEKKSKAELEDLRQRLKD--------LEDK-----EKKENKKMA 696
            RS A K +  + QL    K+ K +L+++   +K         LE K     E+ +N+   
Sbjct: 1770 RSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKE 1829

Query: 697  DEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREK 756
             + A +++R  E++++ +  ++   ++  E    + D          + + RL Q  R+ 
Sbjct: 1830 RQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQAD----------KASTRLKQLKRQL 1879

Query: 757  DDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRK 804
            ++A      E  ++N   + L+ E E+  +    +  +V +    +R+
Sbjct: 1880 EEAE----EEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 134/726 (18%), Positives = 308/726 (42%), Gaps = 60/726 (8%)

Query: 194  KLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKL 253
            K +E V++  ++L + +N + E  ++ L S L  E ++LQE      E      +  ++L
Sbjct: 850  KEEELVKVREKQL-AAENRLTE--METLQSQLMAEKLQLQEQLQAETELCAEAEELRARL 906

Query: 254  QSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSL 313
             +K +  E     LE+ +++ +     ++  ++++ +++ E+ E++  +      A   L
Sbjct: 907  TAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEE----SARQKL 962

Query: 314  YGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQ 373
                +T  A+       +LEE + + +++ C+L K ++  E+   +      E     + 
Sbjct: 963  QLEKVTTEAKL-----KKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKS 1017

Query: 374  VVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKK 433
            + K   ++  M +          + +  L++ R  L G       Q+  ++     L  +
Sbjct: 1018 LAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQ 1077

Query: 434  LRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREM---RHLISSLQNHNHQL 490
            L  +  +L+  LA+V +E     +  ++      Q   +  ++   R   +  +     L
Sbjct: 1078 LAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDL 1137

Query: 491  KGEVLRYKRKLRE------AQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLS 544
              E+   K +L +      AQ +L   R +  + L   ++  E+ K   A+++       
Sbjct: 1138 GEELEALKTELEDTLDSTAAQQELRSKREQEVNIL--KKTLEEEAKTHEAQIQ------E 1189

Query: 545  SQSSASKASQEDANEI-KSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKE 603
             +   S+A +E A ++ ++KR +   E+ ++  E ER     + K   + K   +   K+
Sbjct: 1190 MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKK 1249

Query: 604  RDSAKDKEKGKHDDGRKKEAEI---IKQLKIELKK-----AQESQKEMKLLLDMYRSAPK 655
             ++   + + K ++G +   E+   + +L++EL       +Q   K  KL  D + +   
Sbjct: 1250 VEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKD-FSALES 1308

Query: 656  EQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQ 715
            + +D  +L+  E + K  L     +LK +ED++    +++ +E+  +    +E+QI  L 
Sbjct: 1309 QLQDTQELLQEENRQKLSLS---TKLKQVEDEKNSFREQLEEEEEAK--HNLEKQIATLH 1363

Query: 716  KKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHK 775
             ++A  K++ E  +  ++   +    +Q+    L Q+  EK  A  KL   + +  Q   
Sbjct: 1364 AQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQ--- 1420

Query: 776  LLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKR 835
                   EL D ++ L  Q  +   + +K ++ + LL        K    R +A    + 
Sbjct: 1421 -------ELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEARE 1473

Query: 836  KAMEAAQLADDL------KAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRL 889
            K  +A  LA  L      KA+LE   K+     ++++ +     K +   ++++  + + 
Sbjct: 1474 KETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQ 1533

Query: 890  RRKLET 895
              +++T
Sbjct: 1534 VEEMKT 1539



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 79/358 (22%), Positives = 167/358 (46%), Gaps = 43/358 (12%)

Query: 594  KQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIK-QLKIELKKAQES-QKEMKLLLDMYR 651
            +Q+ +   KE +  K +EK    + R  E E ++ QL  E  + QE  Q E +L  +   
Sbjct: 842  RQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEE 901

Query: 652  SAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMAD-EDALRKIRAVEE- 709
               +    K +L       +A +E+  +R + L+ ++KK  + + + E+ L +  +  + 
Sbjct: 902  LRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQK 961

Query: 710  -QIEYLQKKLAMAKQEEEALLSE-----MDVTGQAFEDM----------QEQNIRLMQQL 753
             Q+E +  +  + K EEE ++ E     +    +  ED           +E+  + + +L
Sbjct: 962  LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL 1021

Query: 754  REKDDANFKLMSERIKSNQ--------IHKLLKEEKEELADQVLTLKTQVDAQLQVVRKL 805
            + K +A    + ER++  +          + L+ +  +L+DQ+  L+ Q+ A+L++  +L
Sbjct: 1022 KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI-AELKM--QL 1078

Query: 806  EEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDL---KAQLELAQKKLHDFQ 862
             +KE  LQ+ +   E+E   +  AL+  +    + ++L +DL   +A    A+K+  D  
Sbjct: 1079 AKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLG 1138

Query: 863  DEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDYKARL 920
            +E+ E   T+ +D  +   AQ+++         +K+   V    + L EE K ++A++
Sbjct: 1139 EEL-EALKTELEDTLDSTAAQQEL--------RSKREQEVNILKKTLEEEAKTHEAQI 1187



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 75/321 (23%), Positives = 141/321 (43%), Gaps = 47/321 (14%)

Query: 642  EMKLLLDMYRSAPKEQRDKVQLMAAEKKSKA------ELEDLRQRLK----DLEDKEKKE 691
            ++K LL + R   +    + +L+   +K  A      E+E L+ +L      L+++ + E
Sbjct: 833  KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE 892

Query: 692  NKKMADEDALR-KIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIR-L 749
             +  A+ + LR ++ A ++++E +   L    +EEE     +    QA +   +QNI+ L
Sbjct: 893  TELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHL----QAEKKKMQQNIQEL 948

Query: 750  MQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQ-----------------VLTLK 792
             +QL E++ A  KL  E++ +    K L+EE+  L DQ                   T  
Sbjct: 949  EEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNL 1008

Query: 793  TQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRK------------AMEA 840
            T+ + + + + KL+ K   + +++    +    + Q LE  +RK            A   
Sbjct: 1009 TEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQ 1068

Query: 841  AQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKKPD 900
            AQ+A +LK QL   +++L      + E +  K   +   +  +  IS L+  LE+ +   
Sbjct: 1069 AQIA-ELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASR 1127

Query: 901  N-VPKCDEILMEEIKDYKARL 920
            N   K    L EE++  K  L
Sbjct: 1128 NKAEKQKRDLGEELEALKTEL 1148



 Score = 32.0 bits (71), Expect = 2.9
 Identities = 33/131 (25%), Positives = 58/131 (44%), Gaps = 14/131 (10%)

Query: 791 LKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAM---EAAQLADDL 847
           L T+V   LQV R+ EE     +  +   EK+L    +  EM   ++    E  QL + L
Sbjct: 830 LFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQL 889

Query: 848 KAQLELAQKKLHDFQDEIVENSVTKEKDMFNF-----KRAQEDISRLRR-KLETTKKPDN 901
           +A+ EL  +      +E+      K++++         R +E+  R +  + E  K   N
Sbjct: 890 QAETELCAE-----AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQN 944

Query: 902 VPKCDEILMEE 912
           + + +E L EE
Sbjct: 945 IQELEEQLEEE 955


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score =  118 bits (295), Expect = 3e-26
 Identities = 179/900 (19%), Positives = 371/900 (41%), Gaps = 128/900 (14%)

Query: 51   LQTKNRKLAEMLDQRQAIEDELREHIEKLER-----RQATDDASLLI--VNRYWSQFDEN 103
            L+ K +++ E L+  + +  EL     KLE      ++  DD  L +  V +     +  
Sbjct: 915  LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENK 974

Query: 104  IRIILKRY-DLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATL 162
            ++ + +    L++ +  L  E+KAL         +++Q+  DD +  E +        T 
Sbjct: 975  VKNLTEEMAGLDEIIAKLTKEKKAL--------QEAHQQALDDLQAEEDKVNTL----TK 1022

Query: 163  ASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELN 222
            A    E+    L+  +E  ++    +     KL+  ++L    +     + +E   Q+L+
Sbjct: 1023 AKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESI-----MDLENDKQQLD 1077

Query: 223  SFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIR 282
              L +++  L  L   ++++    SQ    LQ K++  ++R+  LE  ++  +    K+ 
Sbjct: 1078 ERLKKKDFELNALNARIEDEQALGSQ----LQKKLKELQARIEELEEELEAERTARAKVE 1133

Query: 283  KREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNR 342
            K    L+R L E+ ER+   G           G T           + ++E NK+    R
Sbjct: 1134 KLRSDLSRELEEISERLEEAG-----------GAT-----------SVQIEMNKK----R 1167

Query: 343  LCELEKLRQDFEEVTTQNEKLKVELRS------------------AVEQVVKETPEYRCM 384
              E +K+R+D EE T Q+E     LR                     +++ KE  E++  
Sbjct: 1168 EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 1227

Query: 385  QSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIER---DEVSLHKKLRTE---- 437
                +    + ++ KA+L++    L      H+ + E  +R   D  S   KL+TE    
Sbjct: 1228 LDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGEL 1287

Query: 438  ----------VIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHN 487
                      + QL        ++ E L+ + E+ + A        +  RH    L+   
Sbjct: 1288 SRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQY 1347

Query: 488  HQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQS 547
             +        +R L +A S++ + R +  +  +Q     E+ K + A+   ++E+     
Sbjct: 1348 EEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAV 1407

Query: 548  SASKASQEDANEIKSKRDEE---ERERERREKEREREREREKEKEREREKQKLKESEKER 604
            +A  +S E          E+   + ER         +++R  +K     KQK +ES+ E 
Sbjct: 1408 NAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSEL 1467

Query: 605  DSAKDKEKGKHDDGRKKEAEIIKQLKIELKKA-QESQKEMKLLLDMYRSAPKEQRDKVQL 663
            +S+            +KEA  +     +LK A +ES + ++      ++  +E  D  + 
Sbjct: 1468 ESS------------QKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ 1515

Query: 664  MAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQ 723
            + +  K+  ELE +R++L     + +K   + A E+A   +   E +I   Q +    K 
Sbjct: 1516 LGSSGKTIHELEKVRKQL-----EAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKA 1570

Query: 724  EEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEE 783
            E E  L+E D   +  E  +  ++R++  L+   DA  +  +E ++   + K ++ +  E
Sbjct: 1571 EIERKLAEKD---EEMEQAKRNHLRVVDSLQTSLDAETRSRNEALR---VKKKMEGDLNE 1624

Query: 784  LADQVLTLKTQVDAQLQVVRKLEE--KEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAA 841
            +  Q+           + V+ L+   K+  +Q +      +  L+     + +R  +  A
Sbjct: 1625 MEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAND-DLKENIAIVERRNNLLQA 1683

Query: 842  QLADDLKAQLELAQKKLHDFQDEIVENSV------TKEKDMFNFKRAQE-DISRLRRKLE 894
            +L ++L+A +E  ++     + E++E S       ++   + N K+  + D+S+L+ ++E
Sbjct: 1684 EL-EELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVE 1742



 Score =  106 bits (265), Expect = 9e-23
 Identities = 167/771 (21%), Positives = 313/771 (40%), Gaps = 123/771 (15%)

Query: 66   QAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDENIRIILKRYDLEQGLGDL---LT 122
            + +ED++ EH  K E  Q +       VN   SQ          R  L+   G+L   L 
Sbjct: 1250 RTLEDQMNEHRSKAEETQRS-------VNDLTSQ----------RAKLQTENGELSRQLD 1292

Query: 123  ERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSSSEEMESQLQERVESSR 182
            E++AL+           Q+ +D + + E +  A + LA    S+  + +  L+E+ E   
Sbjct: 1293 EKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDL-LREQYEEET 1351

Query: 183  RAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQEK 242
             A +++  V  K   +V     K  +       +A+Q                T+ L+E 
Sbjct: 1352 EAKAELQRVLSKANSEVAQWRTKYET-------DAIQR---------------TEELEEA 1389

Query: 243  HRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSK 302
             + ++Q   + +  VE   ++ S LE     LQ +I+ +    +R N   A  L++    
Sbjct: 1390 KKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNA-AAAALDKKQRN 1448

Query: 303  GYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDFEEVTTQNEK 362
              K+                +K+EE  +ELE +++ A++   EL KL+  +EE     E 
Sbjct: 1449 FDKILAEWK-----------QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLET 1497

Query: 363  LKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVEL 422
             K E ++  E++   T +          L     QL+A   E ++ L     + +H+   
Sbjct: 1498 FKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE--- 1554

Query: 423  IERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLA-ANEQAGPINREMRHLIS 481
                               E  + + + E+  ++ E E+ LA  +E+     R    ++ 
Sbjct: 1555 -------------------EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVD 1595

Query: 482  SLQ---NHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKP 538
            SLQ   +   + + E LR K+K+   + DLN+  ++   A   +  + +  K   + LK 
Sbjct: 1596 SLQTSLDAETRSRNEALRVKKKM---EGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKD 1652

Query: 539  DSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLK 598
                L     A+   +E+   +     E      + E E  R    + E+ R+  +Q+L 
Sbjct: 1653 TQIQLDDAVRANDDLKENIAIV-----ERRNNLLQAELEELRAVVEQTERSRKLAEQELI 1707

Query: 599  ESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQE-----SQKEMKLLLD---MY 650
            E+ +       +     +  +K +A+ + QL+ E+++A +      +K  K + D   M 
Sbjct: 1708 ETSERVQLLHSQNTSLINQKKKMDAD-LSQLQTEVEEAVQECRNAEEKAKKAITDAAMMA 1766

Query: 651  RSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQ 710
                KEQ     L   +K  +  ++DL+ RL + E    K  KK   +   R +R +E +
Sbjct: 1767 EELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEAR-VRELENE 1825

Query: 711  IEYLQKKLA-----MAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMS 765
            +E  QK+ A     M K E        ++T Q  ED   +N+  +Q L +K       + 
Sbjct: 1826 LEAEQKRNAESVKGMRKSERRI----KELTYQTEED--RKNLLRLQDLVDK-------LQ 1872

Query: 766  ERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNI 816
             ++K+   +K   EE EE A+  L+   +V  +L    + EE+  + +S +
Sbjct: 1873 LKVKA---YKRQAEEAEEQANTNLSKFRKVQHELD---EAEERADIAESQV 1917



 Score =  104 bits (260), Expect = 4e-22
 Identities = 173/740 (23%), Positives = 321/740 (43%), Gaps = 112/740 (15%)

Query: 168  EEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELNSFLAQ 227
            EEM  +   R+ +  +A S+ V       E  +LL R+    D+L+V +    + +F+  
Sbjct: 774  EEMRDERLSRIITRIQAQSRGVLAR---MEYKKLLERR----DSLLVIQ--WNIRAFMGV 824

Query: 228  EN---MRLQ-ELTDLLQEKHR-----TMSQEFSKLQSKVETAESRVSVLESMIDDLQWDI 278
            +N   M+L  ++  LL+   R     +M +EF++L+  +E +E+R   LE  +  L  + 
Sbjct: 825  KNWPWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEK 884

Query: 279  DKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKEL 338
            + ++ + Q    +LA+  ER +            L    I + A K +EMN  LE+ +E+
Sbjct: 885  NDLQLQVQAEQDNLADAEERCD-----------QLIKNKIQLEA-KVKEMNERLEDEEEM 932

Query: 339  -----AQNRLCELE--KLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVL 391
                 A+ R  E E  +L++D +++     K++ E  +   +V   T E   +    + L
Sbjct: 933  NAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKL 992

Query: 392  YNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKE 451
              E    K  L EA           + +V  + + +V    KL  +V  LE +L Q +K 
Sbjct: 993  TKE----KKALQEAHQQALDDLQAEEDKVNTLTKAKV----KLEQQVDDLEGSLEQEKK- 1043

Query: 452  YEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKT 511
               +R++ E+     E    + +E    I  L+N   QL         +L++   +LN  
Sbjct: 1044 ---VRMDLERAKRKLEGDLKLTQES---IMDLENDKQQL-------DERLKKKDFELNAL 1090

Query: 512  RLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERER 571
              R    +   Q+     + +  EL+   E+L  +  A + ++    +++S    E  E 
Sbjct: 1091 NAR----IEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEI 1146

Query: 572  ERREKER------EREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEI 625
              R +E       + E  +++E E ++ ++ L+E+  + ++     + KH D   +  E 
Sbjct: 1147 SERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQ 1206

Query: 626  IKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLE 685
            I  L+   +K ++ + E KL LD          D    M    K+KA LE + + L+D  
Sbjct: 1207 IDNLQRVKQKLEKEKSEFKLELD----------DVTSNMEQIIKAKANLEKMCRTLED-- 1254

Query: 686  DKEKKENKKMADEDALRKIRAVEEQIEYLQK---KLAMAKQEEEALLSEMD----VTGQA 738
              +  E++  A E+  R +  +  Q   LQ    +L+    E+EAL+S++        Q 
Sbjct: 1255 --QMNEHRSKA-EETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQ 1311

Query: 739  FEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQ 798
             ED++ Q   L ++++ K+     L S R   +    LL+E+ EE        +T+  A+
Sbjct: 1312 LEDLKRQ---LEEEVKAKNALAHALQSARHDCD----LLREQYEE--------ETEAKAE 1356

Query: 799  LQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRK----AMEAAQLADDLKAQLELA 854
            LQ  R L +    +       E +   RT+ LE  K+K      EA +  + + A+    
Sbjct: 1357 LQ--RVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSL 1414

Query: 855  QKKLHDFQDEIVENSVTKEK 874
            +K  H  Q+EI +  V  E+
Sbjct: 1415 EKTKHRLQNEIEDLMVDVER 1434



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 115/526 (21%), Positives = 226/526 (42%), Gaps = 75/526 (14%)

Query: 428  VSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLIS----SL 483
            + L +++R E +    T  Q +    + R+E+++ L   +    I   +R  +       
Sbjct: 770  LGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPW 829

Query: 484  QNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDL 543
                 ++K  +   +R+   A      TRL+   AL +S++  ++ +++   L  +  DL
Sbjct: 830  MKLYFKIKPLLKSAEREKEMASMKEEFTRLKE--ALEKSEARRKELEEKMVSLLQEKNDL 887

Query: 544  SSQSSASKASQEDANE-----IKSKRDEEERERERREKEREREREREKEKEREREKQKLK 598
              Q  A + +  DA E     IK+K   E + +E  E+    E E E   E   +K+KL+
Sbjct: 888  QLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNER---LEDEEEMNAELTAKKRKLE 944

Query: 599  E--SEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKE 656
            +  SE +RD                    I  L++ L K +   KE     +  ++  +E
Sbjct: 945  DECSELKRD--------------------IDDLELTLAKVE---KEKHATENKVKNLTEE 981

Query: 657  QRDKVQLMAAEKKSKAELEDLRQR-LKDLEDKEKKENK----KMADEDALRKIRAVEEQI 711
                 +++A   K K  L++  Q+ L DL+ +E K N     K+  E  +  +    EQ 
Sbjct: 982  MAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQE 1041

Query: 712  EYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKD----DANFKLMSER 767
            + ++  L  AK++ E    ++ +T ++  D++    +L ++L++KD      N ++  E+
Sbjct: 1042 KKVRMDLERAKRKLEG---DLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQ 1098

Query: 768  IKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRT 827
               +Q+ K LKE +  + +    L+ +  A+ +V +   +    L+      E+  G  +
Sbjct: 1099 ALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATS 1158

Query: 828  QALEMNKRKAMEAAQLADDL-------KAQLELAQKKLHDFQDEIVENSVTKEKDMFNFK 880
              +EMNK++  E  ++  DL       +A     +KK  D   E+ E             
Sbjct: 1159 VQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQI----------- 1207

Query: 881  RAQEDISRLRRKLETTKKPDNVPKCDEIL--MEEIKDYKARLTCPC 924
               +++ R+++KLE  K    + + D++   ME+I   KA L   C
Sbjct: 1208 ---DNLQRVKQKLEKEKSEFKL-ELDDVTSNMEQIIKAKANLEKMC 1249



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 62/326 (19%), Positives = 135/326 (41%), Gaps = 36/326 (11%)

Query: 40   VSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQ 99
            +++  +  +++LQ+  +     LD      D+L+E+I  +ERR     A L  +     Q
Sbjct: 1635 MAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQ 1694

Query: 100  FDENIRIILKRY-DLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGE----GQEP 154
             + + ++  +   +  + +  L ++  +L+  + + D+D +Q + +  E  +     +E 
Sbjct: 1695 TERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEK 1754

Query: 155  AFSFLATLASSSSE-EMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLI 213
            A   +   A  + E + E      +E  ++ + Q +       ++ E ++ K        
Sbjct: 1755 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQK 1814

Query: 214  VEEAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDD 273
            +E  V+EL + L  E  R  E    +++  R + +         +T E R ++L      
Sbjct: 1815 LEARVRELENELEAEQKRNAESVKGMRKSERRIKE------LTYQTEEDRKNLLR----- 1863

Query: 274  LQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELE 333
            LQ  +DK++ + +   R   E  E+ N+                   N  KF ++  EL+
Sbjct: 1864 LQDLVDKLQLKVKAYKRQAEEAEEQANT-------------------NLSKFRKVQHELD 1904

Query: 334  ENKELAQNRLCELEKLRQDFEEVTTQ 359
            E +E A     ++ KLR    ++ T+
Sbjct: 1905 EAEERADIAESQVNKLRAKSRDIGTK 1930


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score =  117 bits (294), Expect = 4e-26
 Identities = 195/944 (20%), Positives = 408/944 (43%), Gaps = 136/944 (14%)

Query: 20   EKKAAVEDSGTTVE--TIKLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIE 77
            E+K  VED    VE  +I  G + +  +L+      + ++L + L   +   D+L+  +E
Sbjct: 433  EEKRKVEDLQFRVEEESITKGDLETQTKLE----HARIKELEQSLLFEKTKADKLQRELE 488

Query: 78   KLERRQATDDASLLIVNRYWSQFDENIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSD 137
              + R AT                E  RI+    DL   + ++   R+ L   +P  D D
Sbjct: 489  --DTRVAT--------------VSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVD 532

Query: 138  SN----QERKDDRERGEGQEPAFSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYD 193
             +    QE    +E+ E          T        ++     R E+ ++ +  + T  +
Sbjct: 533  MSLSLLQEISSLQEKLE-------VTRTDHQREITSLKEHFGAREETHQKEIKALYTATE 585

Query: 194  KLQEKVELLSRKL---NSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEF 250
            KL ++ E L  KL   N  ++ ++     +L + +A     ++EL     +   T + EF
Sbjct: 586  KLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEF 645

Query: 251  SKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAG 310
            ++L++++E           M  D Q +I+ ++ ++       A+ +E + +K  KV    
Sbjct: 646  AELKTQIE----------KMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEK 695

Query: 311  SSLYGGTITINARKFEEMNAELEE--NK-ELAQNRLCELEKLRQDFEEVTTQNEKLKVEL 367
             +      +   +  ++   E+E+  NK + A+ ++ ELE L+    E T   +    +L
Sbjct: 696  ENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL 755

Query: 368  RSAVEQVVKETPEYRCMQSQFSVLYNESLQLKA------HLDEARTLLHGTRGTHQHQVE 421
            ++  E+++      +      S +     QL+A      HL+  +        +   +++
Sbjct: 756  KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQ 815

Query: 422  LIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLIS 481
              E    +L + L +EV Q+++TL    KE ++L+ +F +   A+E+A  + R M+  ++
Sbjct: 816  GRELKLTNLQENL-SEVSQVKETL---EKELQILKEKFAE---ASEEAVSVQRSMQETVN 868

Query: 482  SLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSE 541
             L     Q                SDL K  LR   A ++++   +D ++E  +L    E
Sbjct: 869  KLHQKEEQFN-----------MLSSDLEK--LRENLADMEAKFREKDEREE--QLIKAKE 913

Query: 542  DLSSQ-SSASKASQEDANEIKSKRDE---EERERERREKEREREREREKEKEREREKQKL 597
             L +  +   K S ++++++    DE   +ER+ E  + +  +  E     ++  E   +
Sbjct: 914  KLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTV 973

Query: 598  KESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQ 657
            K  + ++++AK     KH++ +K+    +  L+ +++ +    +E+K   +   S  K +
Sbjct: 974  KAEQSQQEAAK-----KHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTK 1028

Query: 658  RDKV------QLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQI 711
             +++       L+  E K K   E+    L++LE+  K+ +K  A + A   ++ +E+  
Sbjct: 1029 HEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQ-- 1086

Query: 712  EYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSN 771
                    M K++ E L S         ED ++ N +L  +L    + N K + E  KS 
Sbjct: 1087 --------MTKEKTETLAS--------LEDTKQTNAKLQNELDTLKENNLKNVEELNKSK 1130

Query: 772  QIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELG------- 824
            ++  +  ++ EE   ++ TLK     + Q +  L+E+   L   +G    E+        
Sbjct: 1131 ELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEE 1190

Query: 825  ----LRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFK 880
                L  Q LEM KR++ +  + AD+ KA L   QK +       + +++  EKD    +
Sbjct: 1191 ERSVLNNQLLEMKKRES-KFIKDADEEKASL---QKSIS------ITSALLTEKDA-ELE 1239

Query: 881  RAQEDISRLRRKLETTKKPDNVP---KCDEILME-EIKDYKARL 920
            + + +++ LR +  + K   +V    + D++ +E ++K+ + +L
Sbjct: 1240 KLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQL 1283



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 97/480 (20%), Positives = 197/480 (41%), Gaps = 61/480 (12%)

Query: 491 KGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSAS 550
           K +    +R +    + L ++   S  + + S +S+   +     L  ++    ++  + 
Sbjct: 290 KAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISG 349

Query: 551 KASQEDANEIKSKRDEE---ERERERREKEREREREREKEKEREREKQKLKESEKERDSA 607
             + ++A + K +  E+   ER+ ER E  +      E E+E    +    +   E ++ 
Sbjct: 350 TTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAK 409

Query: 608 KDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAE 667
            D+ +   +   +++ E++ QL+ E +K ++ Q  ++          +E   K  L    
Sbjct: 410 MDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVE----------EESITKGDLETQT 459

Query: 668 KKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEA 727
           K   A +++L Q L  L +K K +  +   ED      + + +I  L+K LA+  QE   
Sbjct: 460 KLEHARIKELEQSL--LFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAE 517

Query: 728 LLSEMDVTGQAFE-DMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELAD 786
           L   ++    A + DM    ++ +  L+EK +         I S + H   +EE      
Sbjct: 518 LRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREE------ 571

Query: 787 QVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKE---------------LGLRTQALE 831
              T + ++ A      KL ++   L+S +    KE               +    QA+E
Sbjct: 572 ---THQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAME 628

Query: 832 -----MNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDI 886
                 +K    E A+ A +LK Q+E   K   D+Q EI   ++  ++D      A+E +
Sbjct: 629 ELKVSFSKGLGTETAEFA-ELKTQIE---KMRLDYQHEI--ENLQNQQDSERAAHAKE-M 681

Query: 887 SRLRRKL-ETTKKPDN--------VPKCDEILMEEIKDYKARLTCPCCNMRKKDAVLTKC 937
             LR KL +  K+ +N        + K ++  + E++D   +L      +++ + +  KC
Sbjct: 682 EALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKC 741



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 103/561 (18%), Positives = 220/561 (39%), Gaps = 90/561 (16%)

Query: 37   LGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQA-----TDDASLL 91
            L  VS  +E   + LQ    K AE  ++  +++  ++E + KL +++      + D   L
Sbjct: 828  LSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKL 887

Query: 92   IVN------RYWSQFDENIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDD 145
              N      ++  + +   ++I  +  LE  + +++         +   D+ S   + +D
Sbjct: 888  RENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM---------KMSGDNSSQLTKMND 938

Query: 146  RER-GEGQEPAFSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDK----LQEKVE 200
              R  E          T A+ ++  ++  +++    + ++  +    +++    L+ K+ 
Sbjct: 939  ELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLS 998

Query: 201  LLSRKLNSGDNLIVE-----------------EAVQELNSFLAQENMRL----QELTDLL 239
             L +K+ +  N   E                 E +Q L   L     +L    +E + LL
Sbjct: 999  DLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLL 1058

Query: 240  QEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIRKREQ---RLNRHLAEVL 296
            QE      Q  +      +TAE  + ++E M  +    +  +   +Q   +L   L + L
Sbjct: 1059 QELEELRKQ--ADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNEL-DTL 1115

Query: 297  ERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQD---- 352
            +  N K  +       L    +T+  +K EE   E+E  K+ A  +  +L  L+++    
Sbjct: 1116 KENNLKNVEELNKSKEL----LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKL 1171

Query: 353  ------FEEVTTQNEKLK----------VELRSAVEQVVKETPEYRC-MQSQFSVLYNES 395
                    +  T ++KL+          +E++    + +K+  E +  +Q   S+     
Sbjct: 1172 AEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALL 1231

Query: 396  LQLKAHLDEAR---TLLHGTRGTHQHQ---VELIERDEVSLHKKLRTEVIQLEDTLAQVR 449
             +  A L++ R   T+L G   + +     V+ +E D+V L  K++   +QL++   Q+ 
Sbjct: 1232 TEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLS 1291

Query: 450  KEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLN 509
                    + ++   A E        +  +I  LQ  N  LK +V      + EA  + N
Sbjct: 1292 SSSGNTDTQADEDERAQESQIDF---LNSVIVDLQRKNQDLKMKV----EMMSEAALNGN 1344

Query: 510  KTRLRSGSALLQSQSSTEDPK 530
               L +  +  Q + S + P+
Sbjct: 1345 GDDLNNYDSDDQEKQSKKKPR 1365


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  116 bits (291), Expect = 9e-26
 Identities = 212/978 (21%), Positives = 405/978 (41%), Gaps = 159/978 (16%)

Query: 18   PPEKKAAVEDSGTTVETIKL--GGVSSTEELDIR---TLQTKNRKLAEMLDQRQAIEDEL 72
            P      V + GT+V+T++     V   E L  R   T+Q+   +   +  +++A++++L
Sbjct: 264  PESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQL 323

Query: 73   REHIEKLERRQATDDASLLIVNRYWSQFDENIRIILKRYDLEQGLGDLLTERK-----AL 127
             E +++LE+     D  +    +  +Q  +   +I     LEQ  G ++ E K      L
Sbjct: 324  DERLQELEK---IKDLHMAEKTKLITQLRDAKNLI---EQLEQDKGMVIAETKRQMHETL 377

Query: 128  VVPEPE---------PDSDSNQERKDDRERGEGQEPAFSFLATLASSSSEEMESQLQERV 178
             + E E           +   +E ++ +E+ E    AF  L    S++ +  E++ + + 
Sbjct: 378  EMKEEEIAQLRSRIKQMTTQGEELREQKEKSE--RAAFEELEKALSTAQKTEEARRKLKA 435

Query: 179  ESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIV-------EEAVQELNSFLAQENMR 231
            E       QI T+    +E+   L ++L+     +V       EE + +L     +E  R
Sbjct: 436  EMD----EQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELAR 491

Query: 232  L-QELTDLLQEKHRTMSQ-----------EFSKLQSKVETAES---------RVSVL--- 267
              QELT  LQ + R   +           E+ K+  + E  ES         + ++L   
Sbjct: 492  KEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTES 551

Query: 268  ESMIDDLQWDIDKIRKREQRLNRHLAEVLE--RVNSKGYKVY-GAGSSLYGGTITINARK 324
            E+ + DLQ + +  R R   L   L + L+  +  SK   V+  A  + +   IT+   K
Sbjct: 552  ENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEK 611

Query: 325  FEEMNAELEENKE---------LAQNRLCELEKLRQDFEE----------------VTTQ 359
             +     L+  ++         L Q    E+EKLR+  E+                +   
Sbjct: 612  HKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEM 671

Query: 360  NEKL-------KVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGT 412
            NEK        + EL S   ++ +       ++ + SVL +++ ++K  L+     +   
Sbjct: 672  NEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELE---AKMDEQ 728

Query: 413  RGTHQHQVE-LIERDEVSL---HKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQ 468
            +  HQ QV+ +I+  EVS+    K L+ ++ QLE  L +  K  +  +   E   A  ++
Sbjct: 729  KNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKR 788

Query: 469  AGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTED 528
            +    ++    +   Q++      +   Y+ +L + Q  L    L +   LL  Q     
Sbjct: 789  SEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKL--LDLETERILLTKQ----- 841

Query: 529  PKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREKEK 588
                 AE++   +D+ ++  A K   +D  +   K++ E  ++ +   +    +  +  K
Sbjct: 842  ----VAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNK 897

Query: 589  EREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLD 648
            E+E+ KQ L E E      +        +G+KKE EI+ Q      K    +  + +L +
Sbjct: 898  EQEQTKQILVEKENMILQMR--------EGQKKEIEILTQ------KLSAKEDSIHILNE 943

Query: 649  MYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVE 708
             Y +  K Q  K++    ++K+K   E L+++L D E K KKE +  A E + ++ +   
Sbjct: 944  EYETKFKNQEKKME--KVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNA 1001

Query: 709  EQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERI 768
            + +E  Q   A        L +      ++  ++  + +  +  + EK     KL  +  
Sbjct: 1002 KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEK-----KLNQQAE 1056

Query: 769  KSNQIHKLLKEEKE----ELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELG 824
            +  +IH++  +EKE    EL  ++L    + +   + +  L+E+          G K+  
Sbjct: 1057 ELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEE----------GVKQDT 1106

Query: 825  LRTQALEMNKRKAMEAAQLADD---LKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKR 881
               +  E  K+K+     LA D   LKA LE   K   D    + EN+  +E+ +     
Sbjct: 1107 TLNELQEQLKQKSAHVNSLAQDETKLKAHLE---KLEVDLNKSLKENTFLQEQLVELKML 1163

Query: 882  AQED---ISRLRRKLETT 896
            A+ED   +S L  KL+TT
Sbjct: 1164 AEEDKRKVSELTSKLKTT 1181



 Score =  109 bits (273), Expect = 1e-23
 Identities = 199/946 (21%), Positives = 403/946 (42%), Gaps = 151/946 (15%)

Query: 51   LQTKNRKLAEMLDQRQ--------AIEDELREHIEKLERRQATDDASLLIVNRYWSQFDE 102
            LQ + +KL  +L Q Q         + +EL+   +  +  Q   DASL   ++Y S    
Sbjct: 167  LQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQT 226

Query: 103  NIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATL 162
             + ++ +R        D+L       +P+ EP ++   + ++    GE           +
Sbjct: 227  QVSLLKQRLRNGPMNVDVLKP-----LPQLEPQAEVFTKEENPESDGE---------PVV 272

Query: 163  ASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELN 222
               +S +    LQ+RV+     + +        +E+  LL+ +         +EA+QE  
Sbjct: 273  EDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSE---------KEALQE-- 321

Query: 223  SFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKIR 282
                Q + RLQEL + +++ H     E +KL +++  A++       +I+ L+ D   + 
Sbjct: 322  ----QLDERLQEL-EKIKDLHMA---EKTKLITQLRDAKN-------LIEQLEQDKGMVI 366

Query: 283  KREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNR 342
               +R      E+ E   ++               +    ++      EL E KE ++  
Sbjct: 367  AETKRQMHETLEMKEEEIAQ---------------LRSRIKQMTTQGEELREQKEKSERA 411

Query: 343  LCE-LEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRC-MQSQFSVLYNESLQLKA 400
              E LEK     ++      KLK E+   ++ + K + E R  +Q + S +  E + +  
Sbjct: 412  AFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMK 471

Query: 401  HLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTL--AQVRKEYEMLRIE 458
               E +      +    H+ EL  R E  L KKL+T   + ++ +  A  + + E L+I 
Sbjct: 472  KSSEEQI----AKLQKLHEKELA-RKEQELTKKLQTREREFQEQMKVALEKSQSEYLKIS 526

Query: 459  FEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDL------NKTR 512
             E+    +     +  + + +++  +N    L+ E   Y+ ++ E +S L      NK +
Sbjct: 527  QEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQ 586

Query: 513  LRSGSALLQSQSS---------TEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSK 563
             +  +  L+++ +          E  K E   LK   + L ++       Q+   E++  
Sbjct: 587  SKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEK-LQVLKQQYQTEMEKL 645

Query: 564  RDEEERERERREKERER--EREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKK 621
            R++ E+E+E   K++E   +   E+  E+  EK  +K++E E  S++  E  K     ++
Sbjct: 646  REKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEE 705

Query: 622  EAEIIK----QLKIELKKAQESQ------------KEMKLLLDMYRSAPKEQRDKVQLMA 665
            E  ++K    ++K EL+   + Q            KE ++ +     A K+Q ++++L+ 
Sbjct: 706  ELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLL 765

Query: 666  AE-----KKSKAELEDLRQRLKDLEDKEKKENKKM-----ADEDALRKIRAVEEQIEYLQ 715
             E     K+ +A +E+L   +K  E + ++ + K+            + +A EEQ+  LQ
Sbjct: 766  KERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQ 825

Query: 716  KKL--------AMAKQEEEALLSEMDV-TGQAFEDMQEQNIRLMQQLREKDDANFKLMSE 766
            +KL         + KQ  E    + DV T      +Q Q+  LMQQL +++      M +
Sbjct: 826  QKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQD--LMQQLEKQNSE----MEQ 879

Query: 767  RIKS-NQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKE-HLLQSNIGTGEKELG 824
            ++KS  Q+++   E+  +  +Q   +  + +  +  +R+ ++KE  +L   +   E  + 
Sbjct: 880  KVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIH 939

Query: 825  LRTQALE---MNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEI---VENS---VTKEKD 875
            +  +  E    N+ K ME  ++    K   E  +KKL D + ++   +EN+   +++++ 
Sbjct: 940  ILNEEYETKFKNQEKKME--KVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEK 997

Query: 876  MFNFKRAQ------EDISRLRRKLETTKKPDNVPKCDEILMEEIKD 915
             FN K  +        IS    +LET +K + +    E+   E+ D
Sbjct: 998  QFNAKMLEMAQANSAGISDAVSRLETNQK-EQIESLTEVHRRELND 1042



 Score = 97.4 bits (241), Expect = 6e-20
 Identities = 176/879 (20%), Positives = 375/879 (42%), Gaps = 101/879 (11%)

Query: 30   TTVETIKLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDAS 89
            T V   KL   +  +E   + L  K   + +M + +       ++ IE L ++ +  + S
Sbjct: 885  TQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQ-------KKEIEILTQKLSAKEDS 937

Query: 90   LLIVN-----RYWSQFDENIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSD--SNQER 142
            + I+N     ++ +Q  +  ++  K  ++++ L   L +++A +  E E  +   S +E+
Sbjct: 938  IHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEK 997

Query: 143  KDDRERGEGQEPAFSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELL 202
            + + +  E  +   + ++   S      + Q++   E  RR ++ ++++++K        
Sbjct: 998  QFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEK-------- 1049

Query: 203  SRKLNSGDNLIVEEAVQELNSFLAQENMRLQELTDLLQE------KHRTMSQEFSKLQSK 256
              KLN        E +QE++    QE  + QE+ +L Q+      +   M++E + L+ +
Sbjct: 1050 --KLNQQ-----AEELQEIHEIQLQE--KEQEVAELKQKILLFGCEKEEMNKEITWLKEE 1100

Query: 257  VETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGG 316
                ++ ++ L+  +      ++ + + E +L  HL E LE   +K  K     + L   
Sbjct: 1101 GVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHL-EKLEVDLNKSLK---ENTFLQEQ 1156

Query: 317  TITI------NARKFEEMNAELEENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSA 370
             + +      + RK  E+ ++L+   E  Q+     EK  +  E+ + + +KL  EL   
Sbjct: 1157 LVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQ 1216

Query: 371  VEQVVKETPEYRCMQSQFSVLYN-ESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVS 429
            ++   K+T     ++++ + L N  S +  A L       H T  T   +  LI+   VS
Sbjct: 1217 LDICCKKTEAL--LEAKTNELINISSSKTNAILSRISHCQHRT--TKVKEALLIKTCTVS 1272

Query: 430  LHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQ 489
                      +LE  L Q+ +E   L I F+Q     E+     + M+  I SL      
Sbjct: 1273 ----------ELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322

Query: 490  LKGEVLRYKRKLREAQS---DLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQ 546
            L+ E    ++   E +S    L K    + +A+   +   ++ K E + L     DL+ Q
Sbjct: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382

Query: 547  SSASKASQEDANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDS 606
               S +  E    I S R + + E+             E   + +    K+    KE+ S
Sbjct: 1383 LQNSISLSEKEAAISSLRKQYDEEK------------CELLDQVQDLSFKVDTLSKEKIS 1430

Query: 607  AKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAA 666
            A ++     DD   K +E  K+ +    + Q + KE+++ L++      E+ +++ L+  
Sbjct: 1431 ALEQV----DDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKE 1486

Query: 667  E-KKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEE 725
            E  +     + L+  ++D + K +K+   +  E   +  R +E +    QK + +    E
Sbjct: 1487 ELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNE 1546

Query: 726  EALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKS--NQIHKL---LKEE 780
              +L   +           Q ++  Q+L E+ D   K   E+I +  NQ++ +   L+ +
Sbjct: 1547 --VLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETK 1604

Query: 781  KEELADQVLTLKTQVD--------AQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEM 832
            K+EL    L++K++ +         + +   KL E +   +  I   +K+L  + +  E 
Sbjct: 1605 KKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEE 1664

Query: 833  NKRKAMEAAQLADDLKAQLELAQKKLHDFQDEI--VENS 869
              +K  E+     +L  +L+  ++++H  ++++  VE+S
Sbjct: 1665 QYKKGTESH--LSELNTKLQEREREVHILEEKLKSVESS 1701



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 188/908 (20%), Positives = 384/908 (42%), Gaps = 139/908 (15%)

Query: 22   KAAVEDSGTTVETIKLGG-----VSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHI 76
            KA +E   T  E ++  G      +S +E  I  L+   ++L+E ++    +++EL+E  
Sbjct: 1310 KADIESLVTEKEALQKEGGNQQQAASEKESCITQLK---KELSENINAVTLMKEELKEKK 1366

Query: 77   EKLER--RQATDDASLLIVNRYWSQFDENIRIILKRYDLE--------QGLG---DLLTE 123
             ++    +Q TD    L  +   S+ +  I  + K+YD E        Q L    D L++
Sbjct: 1367 VEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSK 1426

Query: 124  RKALVVPEPEPDSD--SNQERKDDRERGEGQEPAFSFLATLASSSSEEMESQLQERVESS 181
             K   + + +  S+  S  ++K      + Q         L   S E  E    E++   
Sbjct: 1427 EKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKD--EQINLL 1484

Query: 182  RRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEA------VQELNSFLAQENMRLQEL 235
            +  + Q    +D L+ ++E    K+   ++ +  E       + EL   + Q+ + ++ L
Sbjct: 1485 KEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESL 1544

Query: 236  TDLLQE-------KHRTMSQEFSKLQ-------SKVETAESRVSVLESMIDDLQWDIDKI 281
             ++L+        +H+ + Q+    Q       ++V+ AE ++  LE+ +  ++ +++  
Sbjct: 1545 NEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETK 1604

Query: 282  RKREQRLN-------RHLAEVLERVNSKGY-KVYGAGSSLYGGTITINARKFEEMNAELE 333
            +K  + +N         L  + +R+ S+   K+             I  +   +M  + E
Sbjct: 1605 KKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEE 1664

Query: 334  ENKELAQNRLCELE-KLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLY 392
            + K+  ++ L EL  KL++   EV    EKLK     +VE            QS+  ++ 
Sbjct: 1665 QYKKGTESHLSELNTKLQEREREVHILEEKLK-----SVES----------SQSETLIVP 1709

Query: 393  NESLQLKAHLDEARTLLHG-TRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKE 451
              +  + A+ ++      G  + T++ ++ +++R+     K L+    + E+T   V   
Sbjct: 1710 RSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEET---VSSH 1766

Query: 452  YEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKT 511
            +EM R ++++ L   E A     E + +I  LQ        E L  K K + +       
Sbjct: 1767 FEM-RCQYQERLIKLEHAEAKQHEDQSMIGHLQ--------EELEEKNK-KYSLIVAQHV 1816

Query: 512  RLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSK---RDEEE 568
                G   +Q++ + E+  D+  +   + E L+ Q    K  + D+  ++ K   R E E
Sbjct: 1817 EKEGGKNNIQAKQNLENVFDDVQKTLQEKE-LTCQILEQKIKELDSCLVRQKEVHRVEME 1875

Query: 569  RERERREK--------------EREREREREKEKEREREKQKLKESEKERDSAKDKEKGK 614
                + EK              E   E   EK K    + + L   E + +  + K  G 
Sbjct: 1876 ELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGA 1935

Query: 615  HDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAEL 674
              + +K   EI++  K      +E Q+E+++L        K++ D+ +    E+K K E 
Sbjct: 1936 EREKQKLGKEIVRLQKDLRMLRKEHQQELEIL--------KKEYDQER----EEKIKQEQ 1983

Query: 675  EDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDV 734
            EDL          E K N  +      + +R    Q+   +++L M    +E +    +V
Sbjct: 1984 EDL----------ELKHNSTLK-----QLMREFNTQLAQKEQELEMT--IKETINKAQEV 2026

Query: 735  TGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQ 794
              +  E  QE+  +L++++ EKDD + K  ++R +     ++L   +EE+  +V  L+TQ
Sbjct: 2027 EAELLESHQEETNQLLKKIAEKDD-DLKRTAKRYE-----EILDAREEEMTAKVRDLQTQ 2080

Query: 795  V-DAQLQVVRKLEEKEHLLQSNIGTGE--KELGLRTQALEMNKRKAMEAAQLADDLKAQL 851
            + + Q +  +KLE++E+    N+   E   +L  +T  +  +K K  E  +   +L+ +L
Sbjct: 2081 LEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRL 2140

Query: 852  ELAQKKLH 859
            +  +K ++
Sbjct: 2141 KKYEKNVY 2148



 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 136/676 (20%), Positives = 300/676 (44%), Gaps = 91/676 (13%)

Query: 244 RTMSQE-FSKLQSKVETAE-SRVSVLESMIDDLQWDIDKIRKRE--QRLNRHLAEVLERV 299
           RT S+E  ++L     TA     S ++S  +DL  + D + K +  QRL R     +ER 
Sbjct: 95  RTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRR-----MERS 149

Query: 300 NSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRLCEL-EKLRQDFEEVTT 358
            S     Y    + Y     +  R+ +++   L ++++ +  R+ EL E+L+ D      
Sbjct: 150 LSSYRGKYSELVTAY----QMLQREKKKLQGILSQSQDKSLRRIAELREELQMD------ 199

Query: 359 QNEKLKVELRSAVEQVVKETPEY-RCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQ 417
             ++ K  L+   +  ++E  +Y   +Q+Q S+L         ++D  + L        +
Sbjct: 200 --QQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQ-----LE 252

Query: 418 HQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMR 477
            Q E+  ++E   + +   E + +ED  +    E    R++ ++ L            ++
Sbjct: 253 PQAEVFTKEE---NPESDGEPV-VEDGTSVKTLETLQQRVKRQENL------------LK 296

Query: 478 HLISSLQNHNHQ---LKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPA 534
               ++Q+H  Q   L  E    + +L E   +L K +    +   +  +   D K+   
Sbjct: 297 RCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIE 356

Query: 535 ELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKEREREREREKEKEREREK 594
           +L+ D   + +++      +   +E    ++EE  +   R K+   + E  +E++ + E+
Sbjct: 357 QLEQDKGMVIAET------KRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSER 410

Query: 595 QKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQES----QKEM----KLL 646
              +E EK   +A+  E+ +    RK +AE+ +Q+K   K ++E     Q+E+    + +
Sbjct: 411 AAFEELEKALSTAQKTEEAR----RKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEV 466

Query: 647 LDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRA 706
           +D+ + + +EQ  K+Q +  ++ ++ E    ++  K L+ +E++  ++M       K+  
Sbjct: 467 VDVMKKSSEEQIAKLQKLHEKELARKE----QELTKKLQTREREFQEQM-------KVAL 515

Query: 707 VEEQIEYLQKKLAMAKQEEEAL-LSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMS 765
            + Q EYL  K++  K+++E+L L E+++  +A     E  +R +QQ  E     ++   
Sbjct: 516 EKSQSEYL--KISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAE----TYRTRI 569

Query: 766 ERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEK-----EHLLQSNIGTGE 820
             ++S+ + K L+E K +  D  + L+ + +   + +  + EK     E L         
Sbjct: 570 LELESS-LEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWT 628

Query: 821 KELGLRTQALEMNKRKAMEAAQLADD--LKAQLELAQKKLHDFQDEIVENSVTKEKDMFN 878
           ++L +  Q  +    K  E  +   +  LK +  + Q  + +  ++ +E    K+ ++ +
Sbjct: 629 EKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELES 688

Query: 879 FKRAQEDISRLRRKLE 894
                 ++ + R KLE
Sbjct: 689 LSSELSEVLKARHKLE 704


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score =  115 bits (288), Expect = 2e-25
 Identities = 184/892 (20%), Positives = 381/892 (42%), Gaps = 156/892 (17%)

Query: 51   LQTKNRKLAEMLDQRQAIEDELREHIEKLER-----RQATDDASLLI--VNRYWSQFDEN 103
            L+ K +++ E  ++ + I  EL     KLE      ++  DD  L +  V +     +  
Sbjct: 918  LEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 977

Query: 104  IRIILKRY-DLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATL 162
            ++ + +    L++ +  L  E+KAL         +++Q+  DD +  E +    +   T 
Sbjct: 978  VKNLTEEMAGLDETIAKLSKEKKAL--------QETHQQTLDDLQAEEDKVNILTKAKTK 1029

Query: 163  ASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQELN 222
                 +++E  L++                 KL+  +E   RKL  GD  + +E+  ++ 
Sbjct: 1030 LEQQVDDLEGSLEQE---------------KKLRMDLERAKRKLE-GDLKLAQESTMDME 1073

Query: 223  SFLAQENMRLQ----ELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDI 278
            +   Q + +L+    E+++L+ +     + E  +LQ K++  ++R+  L   I+  +   
Sbjct: 1074 NDKQQLDEKLEKKEFEISNLISKIEDEQAVEI-QLQKKIKELQARIEELGEEIEAERASR 1132

Query: 279  DKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKEL 338
             K  K+   L+R L E+ ER+   G           G T           +A++E NK+ 
Sbjct: 1133 AKAEKQRSDLSRELEEISERLEEAG-----------GAT-----------SAQVELNKK- 1169

Query: 339  AQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPE-YRCMQSQFSVLYNESLQ 397
               R  E +KLR+D EE T Q+E +   LR      + E  E    +Q     L  E  +
Sbjct: 1170 ---REAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSE 1226

Query: 398  LKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRI 457
            LK   D+  +             E I + + +L K  R+    LED +++++ + E    
Sbjct: 1227 LKMETDDLSS-----------NAEAISKAKGNLEKMCRS----LEDQVSELKTKEE---- 1267

Query: 458  EFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQ---SDLNKTRLR 514
                             E + LI+ L     +L+ E   Y R+L E     S L++++  
Sbjct: 1268 -----------------EQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSK-- 1308

Query: 515  SGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERR 574
                    Q+ST+  ++   +L+ +++  ++ + A ++S+ D + ++ + +EE+  +   
Sbjct: 1309 --------QASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAEL 1360

Query: 575  EKEREREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELK 634
            ++   +      +   + E   ++ +E+  ++ K   +   +     EA   K   +E  
Sbjct: 1361 QRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKT 1420

Query: 635  KAQESQKEMKLLLDMYRS------APKEQR--DKV-------------QLMAAEKKSKA- 672
            K +   +   L+LD+ RS        K+QR  DKV             +L A++K+S++ 
Sbjct: 1421 KQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSL 1480

Query: 673  -----ELEDLRQRLKDLEDKEKKENKKMADE--DALRKIRAVEEQIEYLQKKLAMAKQEE 725
                 +++++ +   D  +  ++ENK +  E  D   +I    +QI  L+K     +QE+
Sbjct: 1481 STELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEK 1540

Query: 726  EALLSEMDVTGQAFEDMQEQNIRLMQQLRE-KDDANFKLMSERIKSNQIHKLLKEEKEEL 784
              + + ++    + E  + + +R+  +L + K + + K+     K  +I +L +     +
Sbjct: 1541 CEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAE---KDEEIDQLKRNHTRVV 1597

Query: 785  ADQVLTLKTQVDAQ---LQVVRKLEE--KEHLLQSNIGTGEKELGLR----TQA-LEMNK 834
                 TL  ++ ++   L+V +K+E    E  +Q N         LR    TQ  L+  +
Sbjct: 1598 ETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQ 1657

Query: 835  RKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDI 886
                +A +  +DLK QL + +++ +  Q EI E   T E+   + K A++++
Sbjct: 1658 LHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQEL 1709



 Score =  111 bits (277), Expect = 4e-24
 Identities = 177/895 (19%), Positives = 372/895 (41%), Gaps = 100/895 (11%)

Query: 36   KLGGVSSTEELDIRTLQTKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNR 95
            KL G     +     ++   ++L E L+++   E E+   I K+E  QA +         
Sbjct: 1057 KLEGDLKLAQESTMDMENDKQQLDEKLEKK---EFEISNLISKIEDEQAVE--------- 1104

Query: 96   YWSQFDENIRIILKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPA 155
               Q  + I+ +  R +    LG+ +   +A      +  SD ++E ++  ER E    A
Sbjct: 1105 --IQLQKKIKELQARIE---ELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGA 1159

Query: 156  FSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVE 215
             S    L      E +   ++  E++ +  + +  +  K  + +  L  ++   DNL   
Sbjct: 1160 TSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQI---DNL--- 1213

Query: 216  EAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQ 275
               Q +   L +E   L+  TD L      +S+    L+    + E +VS L++  ++ Q
Sbjct: 1214 ---QRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQ 1270

Query: 276  WDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEEN 335
              I+ +  +  RL     E   +++ K   V     S    T     ++ EE+  +LEE 
Sbjct: 1271 RLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAST-----QQIEELKHQLEEE 1325

Query: 336  KELAQNRLCE-LEKLRQDFEEVTTQNEKL---KVELRSAVEQVVKETPEYRCMQSQFSVL 391
             + A+N L   L+  R D + +  Q E+    K EL+ A+ +   E  ++R         
Sbjct: 1326 TK-AKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYE----- 1379

Query: 392  YNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKE 451
              +++Q    L+EA+  L       +  VE +     SL K           T  +++ E
Sbjct: 1380 -TDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEK-----------TKQRLQNE 1427

Query: 452  YEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKT 511
             E L ++ E++ AA        R    ++S  +    + + E+   +++ R   ++L K 
Sbjct: 1428 VEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKV 1487

Query: 512  RLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERER 571
            +    +   +S    E  + E   L+ +  DL+ Q +       +  +IK + ++E+ E 
Sbjct: 1488 K----NVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEI 1543

Query: 572  ERREKEREREREREKEK--EREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQL 629
            +   +E E   E E+ K    + E  ++K     + + KD+E    D  ++    +++ +
Sbjct: 1544 QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEI---DQLKRNHTRVVETM 1600

Query: 630  KIELKKAQESQKEMKLLLDMYRSAPKEQRD----KVQLMAAEKKSKAELEDLRQRLKDLE 685
            +  L        E++   D  R   K + D    ++QL  A + +   L + R     L+
Sbjct: 1601 QSTL------DAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILK 1654

Query: 686  DKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQ 745
            + +      +  +DALR    ++EQ+  ++++  + + E E L + ++ T ++ +  +++
Sbjct: 1655 ETQ------LHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQE 1708

Query: 746  NIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTL-----KTQVDAQLQ 800
             +   ++++     N  L++ + K       L+ E EE+  +         K   DA + 
Sbjct: 1709 LLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMM 1768

Query: 801  VVRKLEEKE---HL--LQSNIGTGEKELGLRTQ-----ALEMNKRKAMEAAQLADDLKAQ 850
                 +E++   HL  ++ N+    K+L  R       AL+  K++  +      +L+ +
Sbjct: 1769 AEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGE 1828

Query: 851  LELAQKK-------LHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKK 898
            +E  QK+       L   +  + E +   E+D  N  R Q+ + +L+ K+++ K+
Sbjct: 1829 VENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKR 1883



 Score =  106 bits (264), Expect = 1e-22
 Identities = 155/792 (19%), Positives = 333/792 (42%), Gaps = 127/792 (16%)

Query: 57   KLAEMLDQRQAIEDELREHIEKLERRQATDDASLLI---------VNRYWSQFDENIRII 107
            +L E +D  Q ++ +L +  EK E +  TDD S            + +     ++ +  +
Sbjct: 1205 ELGEQIDNLQRVKQKLEK--EKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSEL 1262

Query: 108  LKRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSSS 167
              + + +Q L + LT ++A +  E    S    E+          +   S L+    +S+
Sbjct: 1263 KTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEK----------DALVSQLSRSKQAST 1312

Query: 168  EEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDN--LIVEEAVQELNSFL 225
            +++E +L+ ++E   +A + +       +   +LL  +          ++ A+ + NS +
Sbjct: 1313 QQIE-ELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEV 1371

Query: 226  AQENMRLQ----ELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKI 281
            AQ   + +    + T+ L+E  + ++Q   + +  VE   ++ + LE     LQ +++ +
Sbjct: 1372 AQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDL 1431

Query: 282  RKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQN 341
                +R N   A + ++  +            +   ++   +K+EE  AELE +++ +++
Sbjct: 1432 MLDVERSNAACAALDKKQRN------------FDKVLSEWKQKYEETQAELEASQKESRS 1479

Query: 342  RLCELEKLRQDFEE-------VTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNE 394
               EL K++  +EE       +  +N+ L+ E+    EQ+ +   +   ++     +  E
Sbjct: 1480 LSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQE 1539

Query: 395  SLQLKAHLDEARTLLHGTRG------THQHQV------ELIERD-EVSLHKKLRTEVIQ- 440
              +++A L+EA   L    G         +QV      ++ E+D E+   K+  T V++ 
Sbjct: 1540 KCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVET 1599

Query: 441  LEDTL-AQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKR 499
            ++ TL A++R   + LR++ +     NE    +N   R    SL+N+             
Sbjct: 1600 MQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNY------------- 1646

Query: 500  KLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANE 559
              R  Q  L +T+L    AL       ED K          E L+     +   Q +  E
Sbjct: 1647 --RNTQGILKETQLHLDDAL----RGQEDLK----------EQLAIVERRANLLQAEIEE 1690

Query: 560  IKSKRDEEERERERREKEREREREREKEKERE-----REKQKLKESEKERDSAKD---KE 611
            + +  ++ ER R+  E+E     ER +    +       K+KL+    +  S  +   +E
Sbjct: 1691 LWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQE 1750

Query: 612  KGKHDDGRKKEAEIIKQLKIELKKAQESQ---KEMKLLLDMYRSAPKEQRDKVQLMAAEK 668
                ++  KK       +  ELKK Q++    + MK  L+      + + D+ + +A  K
Sbjct: 1751 SRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAL-K 1809

Query: 669  KSKAELEDLRQRLKDLEDKEKKENKKMAD-------------------EDALRKIRAVEE 709
              K +++ L  R+++LE + + E K+ A+                   E+  + +  +++
Sbjct: 1810 GGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQD 1869

Query: 710  QIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDD-ANFKLMSERI 768
             ++ LQ K+   K++ E    + +     F  +Q +    +++  E+ D A  ++   R+
Sbjct: 1870 LVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHE----LEEAEERADIAESQVNKLRV 1925

Query: 769  KSNQIHKLLKEE 780
            KS ++H  +  E
Sbjct: 1926 KSREVHTKISAE 1937



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 130/648 (20%), Positives = 284/648 (43%), Gaps = 109/648 (16%)

Query: 320  INARKFEEMNAELEENKELAQNRLCELEKLRQDFEE--VTTQNEKLKVELRSAVEQVVKE 377
            + + + E+  A ++E  +  ++ L + E  R++ EE  VT   EK  ++L+   E     
Sbjct: 843  LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLA 902

Query: 378  TPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQHQVELIERDEVSLHKKLRTE 437
              E RC Q     L    +QL+A + E                E  E +E  ++ +L  +
Sbjct: 903  DAEERCEQ-----LIKNKIQLEAKIKEV--------------TERAEEEE-EINAELTAK 942

Query: 438  VIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRY 497
              +LED  ++++K+ +    + E TLA       + +E     + ++N   ++ G     
Sbjct: 943  KRKLEDECSELKKDID----DLELTLAK------VEKEKHATENKVKNLTEEMAG----- 987

Query: 498  KRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDA 557
               L E  + L+K +     AL ++   T D      +L+ + + ++  + A    ++  
Sbjct: 988  ---LDETIAKLSKEK----KALQETHQQTLD------DLQAEEDKVNILTKAKTKLEQQV 1034

Query: 558  NEIKSKRDEEER-----ERERREKEREREREREKEKEREREKQKLKESEKERDSAKDKEK 612
            ++++   ++E++     ER +R+ E + +  +E   + E +KQ+L E  ++++       
Sbjct: 1035 DDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLI 1094

Query: 613  GKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKA 672
             K +D +  E ++ K++K    + +E  +E++                     AE+ S+A
Sbjct: 1095 SKIEDEQAVEIQLQKKIKELQARIEELGEEIE---------------------AERASRA 1133

Query: 673  ELE----DLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEAL 728
            + E    DL + L+++ ++ ++     + +  L K R  E + + L++ L  A  + EA+
Sbjct: 1134 KAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKR--EAEFQKLRRDLEEATLQHEAM 1191

Query: 729  LSEMDVT-GQAFEDMQEQ--NIRLMQQLREKDDANFKLMSERIKSNQ--IHKL---LKEE 780
            ++ +      +  ++ EQ  N++ ++Q  EK+ +  K+ ++ + SN   I K    L++ 
Sbjct: 1192 VAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKM 1251

Query: 781  KEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEA 840
               L DQV  LKT+ + Q +++  L  +   LQ+  G   ++L  +   +    R    +
Sbjct: 1252 CRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAS 1311

Query: 841  AQLADDLKAQLE-----------LAQKKLHD---FQDEIVENSVTKEKDMFNFKRAQEDI 886
             Q  ++LK QLE             Q   HD    +++  E    K +      +A  ++
Sbjct: 1312 TQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEV 1371

Query: 887  SRLRRKLET-----TKKPDNVPKCDEILMEEIKDYKARLTCPCCNMRK 929
            ++ R K ET     T++ +   K     ++E +++   +   C ++ K
Sbjct: 1372 AQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEK 1419


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  115 bits (287), Expect = 3e-25
 Identities = 199/1022 (19%), Positives = 415/1022 (40%), Gaps = 214/1022 (20%)

Query: 51   LQTKNRKLAEMLDQRQAIEDEL----REHIEKLERRQATDDASLLIVNRYWSQFDENIRI 106
            LQ K+ +L ++ +++  +E EL    R+H + LE +    +        +    +   R+
Sbjct: 854  LQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARL 913

Query: 107  ILKRYDLEQGLGDLLT------ERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLA 160
              K+ +LE+ L DL +      ER  ++  E +      Q+ ++  +  EG         
Sbjct: 914  AAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEK 973

Query: 161  TLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLIVEEAVQE 220
              A +  ++ME ++    + + + + +   + D++ E    L+ +         EE  + 
Sbjct: 974  VTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE---------EEKAKN 1024

Query: 221  LNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDK 280
            L     ++ + + +L + L+++ +T  QE  K + K++      + L+  I +LQ  ID+
Sbjct: 1025 LAKIRNKQEVMISDLEERLKKEEKTR-QELEKAKRKLD---GETTDLQDQIAELQAQIDE 1080

Query: 281  IRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEE------ 334
            ++ +  +    L   L R         G   +L+        R+ +   AEL+E      
Sbjct: 1081 LKLQLAKKEEELQGALAR---------GDDETLHKNNALKVVRELQAQIAELQEDFESEK 1131

Query: 335  ---NKELAQNRLC--ELEKLRQDFE----------EVTTQNEKLKVELRSAVEQVVKE-- 377
               NK   Q R    ELE L+ + E          E+ T+ E+   EL+ A+E+  K   
Sbjct: 1132 ASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE 1191

Query: 378  ------TPEYRCMQSQFSVLYNESLQLKAHLDEART--------------LLHGTRGTHQ 417
                     +     + S    ++ + KA+L++ +               +L   +   +
Sbjct: 1192 AQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESE 1251

Query: 418  HQVELIERDEVSLHKK------LRTEVIQLE-------DTLAQVRKEYEMLRIEFEQTLA 464
            H+ + ++     LH K      LR E+ +         D ++ + +E E   I+F +  A
Sbjct: 1252 HKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAA 1311

Query: 465  ANEQAGPINREM-------RHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGS 517
            + E      +E+       +  +SS      + K  +   + +  EA+ +L K  L   S
Sbjct: 1312 SLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQS 1371

Query: 518  ALLQSQSSTEDP-------KDEPAELKPDSEDLSSQSSASKASQEDANEIKSK------- 563
             L  ++   +D        ++   +L  D+E LS +      + +   + K++       
Sbjct: 1372 QLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDD 1431

Query: 564  ----------------------------------RDEEERER---ERREKE-------RE 579
                                              R  EER+R   E REKE       R 
Sbjct: 1432 LTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARA 1491

Query: 580  REREREKEKEREREKQKLKESEKERDSAKDKE-KGKHDDGRKKEA--EIIKQLKIELKKA 636
             E   E ++E ER+ ++L+   ++  S+KD   K  H+  + K A  + +++++ +L++ 
Sbjct: 1492 LEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEEL 1551

Query: 637  QE---SQKEMKLLLDMYRSAPKEQ------------RDKVQLMAAE-KKSKAELEDLRQR 680
            ++   + ++ KL L++   A K Q             +K +L+  + ++ +AELED R++
Sbjct: 1552 EDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ 1611

Query: 681  --------------LKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEE 726
                          LKDLE + +  NK  A ++ ++++R ++ Q++  Q++L  A+   +
Sbjct: 1612 RALAVASKKKMEIDLKDLEAQIEAANK--ARDEVIKQLRKLQAQMKDYQRELEEARASRD 1669

Query: 727  ALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELAD 786
             + ++   + +  + ++ + ++L ++L           SER + +      ++E++ELAD
Sbjct: 1670 EIFAQSKESEKKLKSLEAEILQLQEELAS---------SERARRHA-----EQERDELAD 1715

Query: 787  QVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGL-----RTQALEMNKRKA---- 837
            ++    +   A L   R+LE +   L+  +   +  + L     R   L+++   A    
Sbjct: 1716 EITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAA 1775

Query: 838  -MEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETT 896
               AAQ +D+ + QLE   K+L     E+      K K        +  I +L  +LE  
Sbjct: 1776 ERSAAQKSDNARQQLERQNKELKAKLQEL--EGAVKSKFKATISALEAKIGQLEEQLEQE 1833

Query: 897  KK 898
             K
Sbjct: 1834 AK 1835



 Score =  112 bits (279), Expect = 2e-24
 Identities = 157/827 (18%), Positives = 344/827 (41%), Gaps = 114/827 (13%)

Query: 52   QTKNRKLAEMLDQRQAIEDELREH---IEKLERRQATDDASLLIVNRYWSQFDENIRIIL 108
            + + ++  E+ + ++A+E+E + H   I+ + +R AT    L        +F  N+    
Sbjct: 1167 ELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLE--K 1224

Query: 109  KRYDLEQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGEGQEPAFSFLATLASSSSE 168
             +  LE    +L  E K L   + E +   ++ +K D +  E              S  +
Sbjct: 1225 NKQGLETDNKELACEVKVLQQVKAESE---HKRKKLDAQVQELHAKV---------SEGD 1272

Query: 169  EMESQLQERVESSRRAVSQIVTVYDKLQEK-------VELLSRKLNSGDNLIVEEAVQEL 221
             +  +L E+    +  +  + T+ ++ ++K          L  +L     L+ EE  Q+L
Sbjct: 1273 RLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKL 1332

Query: 222  NSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDDLQWDIDKI 281
            N  L+    +L+E  + LQE+     +    L+ +V   +S+++  +  +DD    I+ +
Sbjct: 1333 N--LSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESL 1390

Query: 282  RKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQN 341
             + +++L +    + +R+  K              T     ++ +++  +L+  +++A N
Sbjct: 1391 EEAKKKLLKDAEALSQRLEEKALAY-----DKLEKTKNRLQQELDDLTVDLDHQRQVASN 1445

Query: 342  RLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVKETPEYRCMQSQFSVLYNESLQLKAH 401
                LEK ++ F+++  + + +        ++   E  E        +    E+L+ K  
Sbjct: 1446 ----LEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEE 1501

Query: 402  LDEARTLLHGTR----------GTHQHQVELIERDEVSLHKKLRTEVIQLEDTL-----A 446
             +     L              G + H++E  +R      +++RT++ +LED L     A
Sbjct: 1502 FERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDA 1561

Query: 447  QVRKEYEM--LRIEFEQTLAANEQAGP-----INREMRHLISSLQNHNHQ---------- 489
            ++R E  M  ++ +FE+ L   ++        + +++R L + L++   Q          
Sbjct: 1562 KLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKK 1621

Query: 490  -----------------LKGEVLRYKRKL----REAQSDLNKTRLRSGSALLQSQSSTED 528
                              + EV++  RKL    ++ Q +L + R        QS+ S + 
Sbjct: 1622 MEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKK 1681

Query: 529  PKDEPAELKPDSEDLSSQSSASKASQEDANEI----------KSKRDEEERERERREKER 578
             K   AE+    E+L+S   A + ++++ +E+          KS   +E+R  E R  + 
Sbjct: 1682 LKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQL 1741

Query: 579  EREREREKEK-----EREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIEL 633
            E E E E+       +R R+     ++     +A+     K D+ R++     K+LK +L
Sbjct: 1742 EEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKL 1801

Query: 634  KKAQESQK-EMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAEL-----EDLRQRLKDLEDK 687
            ++ + + K + K  +    +   +  ++++  A E+ +  +L     + L++    +ED+
Sbjct: 1802 QELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDE 1861

Query: 688  EKKENK-KMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQN 746
             +  ++ K   E A  +++ ++ Q+E  +++   A      L  E+D   +A E +  + 
Sbjct: 1862 RRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREV 1921

Query: 747  IRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKT 793
              L  +LR     +F   S R    Q+H  L+    EL+D     KT
Sbjct: 1922 STLKNRLRRGGPISFS--SSRSGRRQLH--LEGASLELSDDDTESKT 1964



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 84/374 (22%), Positives = 186/374 (49%), Gaps = 43/374 (11%)

Query: 582  REREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQK 641
            R+ E+ + ++ E  K+KE + + +   ++ + KH    +++  + +QL+ E +   E+++
Sbjct: 849  RQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEE 908

Query: 642  ----------EMKLLLDMYRSAPKEQRDKVQLMAAEKKS-KAELEDLRQRLKDLEDKEKK 690
                      E++ +L    S  +E+ ++ Q++  EKK  +A ++DL ++L + E   +K
Sbjct: 909  MRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQK 968

Query: 691  ENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEM-DVTGQAFEDMQEQNIRL 749
               +    +A  KI+ +EE+I  L+ + +   +E++ +   + + + Q  E  +E+  + 
Sbjct: 969  LQLEKVTAEA--KIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAE--EEEKAKN 1024

Query: 750  MQQLREKDDANFKLMSERIKSNQ--------IHKLLKEEKEELADQVLTLKTQVDAQLQV 801
            + ++R K +     + ER+K  +          + L  E  +L DQ+  L+ Q+D   ++
Sbjct: 1025 LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQID---EL 1081

Query: 802  VRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDL---KAQLELAQKKL 858
              +L +KE  LQ  +  G+ E   +  AL++ +    + A+L +D    KA    A+K+ 
Sbjct: 1082 KLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQK 1141

Query: 859  HDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDYKA 918
             D  +E+ E   T+ +D  +   AQ+++         TK+   V +  + L EE K+++A
Sbjct: 1142 RDLSEEL-EALKTELEDTLDTTAAQQEL--------RTKREQEVAELKKALEEETKNHEA 1192

Query: 919  RLTCPCCNMRKKDA 932
            ++     +MR++ A
Sbjct: 1193 QIQ----DMRQRHA 1202



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 53/255 (20%), Positives = 129/255 (50%), Gaps = 23/255 (9%)

Query: 680  RLKDLEDKEKKENKKMADEDALRKIRA----VEEQIEYLQKKLAMAKQEEEALLSEMDVT 735
            ++K L    ++E +  A ++ L K++     VE ++E +++K     +E+  L  ++   
Sbjct: 840  KVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAE 899

Query: 736  GQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQV 795
             + F + +E   RL  + +E ++    L S   +  + +++L+ EK+++   +  L+ Q+
Sbjct: 900  TELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL 959

Query: 796  DAQLQVVRKLEEKEHLLQSNIGTGEKELGL--RTQALEMNKRKAME------AAQLADDL 847
            D +    +KL+ ++   ++ I   E+E+ L     +  + ++K ME      ++QLA++ 
Sbjct: 960  DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEE 1019

Query: 848  KAQLELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKL--ETTKKPDNVPKC 905
            +    LA  K+ + Q+ ++ +    E+ +   ++ ++++ + +RKL  ETT   D + + 
Sbjct: 1020 EKAKNLA--KIRNKQEVMISD---LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAE- 1073

Query: 906  DEILMEEIKDYKARL 920
               L  +I + K +L
Sbjct: 1074 ---LQAQIDELKLQL 1085


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.127    0.332 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,013,795
Number of Sequences: 37866
Number of extensions: 1585464
Number of successful extensions: 66298
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1299
Number of HSP's successfully gapped in prelim test: 1657
Number of HSP's that attempted gapping in prelim test: 12758
Number of HSP's gapped (non-prelim): 16749
length of query: 975
length of database: 18,247,518
effective HSP length: 112
effective length of query: 863
effective length of database: 14,006,526
effective search space: 12087631938
effective search space used: 12087631938
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.