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Search of human proteins with 33383239
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33383239 protein kinase Myt1 isoform 2 [Homo sapiens]
(480 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33383239 protein kinase Myt1 isoform 2 [Homo sapiens] 1018 0.0
gi|33383241 protein kinase Myt1 isoform 1 [Homo sapiens] 918 0.0
gi|221307502 WEE1 tyrosine kinase isoform 2 [Homo sapiens] 148 1e-35
gi|4507917 WEE1 tyrosine kinase isoform 1 [Homo sapiens] 148 1e-35
gi|157738687 WEE1 homolog 2 [Homo sapiens] 135 1e-31
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 112 7e-25
gi|41872673 NIMA-related kinase 1 [Homo sapiens] 108 8e-24
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 107 3e-23
gi|6005810 mitogen-activated protein kinase kinase kinase kinase... 107 3e-23
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 106 5e-23
gi|41872374 polo-like kinase 3 [Homo sapiens] 103 3e-22
gi|55956904 mitogen-activated protein kinase kinase kinase 4 iso... 103 5e-22
gi|55956902 mitogen-activated protein kinase kinase kinase 4 iso... 103 5e-22
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 102 8e-22
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 101 2e-21
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 101 2e-21
gi|148839316 NIMA-related kinase 4 [Homo sapiens] 100 4e-21
gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Ho... 100 5e-21
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 100 5e-21
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens] 99 9e-21
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens] 99 9e-21
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens] 99 9e-21
gi|19424132 NIMA-related kinase 7 [Homo sapiens] 97 2e-20
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 97 3e-20
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 97 3e-20
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 96 6e-20
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 95 1e-19
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens] 94 4e-19
gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens] 93 5e-19
gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens] 93 5e-19
>gi|33383239 protein kinase Myt1 isoform 2 [Homo sapiens]
Length = 480
Score = 1018 bits (2633), Expect = 0.0
Identities = 480/480 (100%), Positives = 480/480 (100%)
Query: 1 MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGS 60
MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGS
Sbjct: 1 MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGS 60
Query: 61 IPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGS 120
IPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGS
Sbjct: 61 IPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGS 120
Query: 121 YGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEG 180
YGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEG
Sbjct: 121 YGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEG 180
Query: 181 GILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIF 240
GILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIF
Sbjct: 181 GILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIF 240
Query: 241 LGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVA 300
LGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVA
Sbjct: 241 LGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVA 300
Query: 301 CNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLR 360
CNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLR
Sbjct: 301 CNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLR 360
Query: 361 QPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCS 420
QPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCS
Sbjct: 361 QPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCS 420
Query: 421 LLLDSSLSSNWDDDSLGPGHPPCLACPPAGLHSPLRLSWPGLWGAPPPPGAGAHPGMPWT 480
LLLDSSLSSNWDDDSLGPGHPPCLACPPAGLHSPLRLSWPGLWGAPPPPGAGAHPGMPWT
Sbjct: 421 LLLDSSLSSNWDDDSLGPGHPPCLACPPAGLHSPLRLSWPGLWGAPPPPGAGAHPGMPWT 480
>gi|33383241 protein kinase Myt1 isoform 1 [Homo sapiens]
Length = 499
Score = 918 bits (2372), Expect = 0.0
Identities = 439/442 (99%), Positives = 439/442 (99%)
Query: 1 MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGS 60
MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGS
Sbjct: 1 MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGS 60
Query: 61 IPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGS 120
IPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGS
Sbjct: 61 IPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGS 120
Query: 121 YGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEG 180
YGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEG
Sbjct: 121 YGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEG 180
Query: 181 GILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIF 240
GILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIF
Sbjct: 181 GILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIF 240
Query: 241 LGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVA 300
LGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVA
Sbjct: 241 LGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVA 300
Query: 301 CNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLR 360
CNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLR
Sbjct: 301 CNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLR 360
Query: 361 QPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCS 420
QPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCS
Sbjct: 361 QPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCS 420
Query: 421 LLLDSSLSSNWDDDSLGPGHPP 442
LLLDSSLSSNWDDDSLGP P
Sbjct: 421 LLLDSSLSSNWDDDSLGPSLSP 442
>gi|221307502 WEE1 tyrosine kinase isoform 2 [Homo sapiens]
Length = 432
Score = 148 bits (373), Expect = 1e-35
Identities = 101/292 (34%), Positives = 143/292 (48%), Gaps = 43/292 (14%)
Query: 100 SRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVG 159
S +S + F L ++G G +G VFK + DG +YA+KRS P G D L EV
Sbjct: 75 SNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVY 134
Query: 160 SHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGY------ 213
+H +GQH VR AW E + +Q E C G SL +A Y
Sbjct: 135 AHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCN----------GGSLADAISENYRIMSYF 184
Query: 214 ----LRDTLL----ALAHLHSQGLVHLDVKPANIFLG----PRGRCKLGD---------- 251
L+D LL L ++HS LVH+D+KP+NIF+ P + GD
Sbjct: 185 KEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVM 244
Query: 252 --FGLLVELGTAGAGEVQEGDPRYMAPELLQGSYG--TAADVFSLGLTILEVACNMELPH 307
G L + + +V+EGD R++A E+LQ +Y AD+F+L LT++ A LP
Sbjct: 245 FKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPR 304
Query: 308 GGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVL 359
G+ W ++RQG L P LS E +L +M+ PDP+ R +A AL+ VL
Sbjct: 305 NGDQWHEIRQGRL-PRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVL 355
>gi|4507917 WEE1 tyrosine kinase isoform 1 [Homo sapiens]
Length = 646
Score = 148 bits (373), Expect = 1e-35
Identities = 101/292 (34%), Positives = 143/292 (48%), Gaps = 43/292 (14%)
Query: 100 SRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVG 159
S +S + F L ++G G +G VFK + DG +YA+KRS P G D L EV
Sbjct: 289 SNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVY 348
Query: 160 SHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGY------ 213
+H +GQH VR AW E + +Q E C G SL +A Y
Sbjct: 349 AHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCN----------GGSLADAISENYRIMSYF 398
Query: 214 ----LRDTLL----ALAHLHSQGLVHLDVKPANIFLG----PRGRCKLGD---------- 251
L+D LL L ++HS LVH+D+KP+NIF+ P + GD
Sbjct: 399 KEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVM 458
Query: 252 --FGLLVELGTAGAGEVQEGDPRYMAPELLQGSYG--TAADVFSLGLTILEVACNMELPH 307
G L + + +V+EGD R++A E+LQ +Y AD+F+L LT++ A LP
Sbjct: 459 FKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPR 518
Query: 308 GGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVL 359
G+ W ++RQG L P LS E +L +M+ PDP+ R +A AL+ VL
Sbjct: 519 NGDQWHEIRQGRL-PRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVL 569
>gi|157738687 WEE1 homolog 2 [Homo sapiens]
Length = 567
Score = 135 bits (339), Expect = 1e-31
Identities = 94/286 (32%), Positives = 136/286 (47%), Gaps = 33/286 (11%)
Query: 104 SFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEK 163
S +++ F + ++G G +G V+K + DG +YA+KRSM F + L EV +H
Sbjct: 206 SRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAV 265
Query: 164 VGQHPCCVRLEQAWEEGGILYLQTELC-GPSLQ---QHCEAWGASLPEAQVWGYLRDTLL 219
+G HP VR +W E + +Q E C G SLQ G E ++ L L
Sbjct: 266 LGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISL 325
Query: 220 ALAHLHSQGLVHLDVKPANI-----------------------FLGPRGRCKLGDFGLLV 256
L ++H+ +VHLD+KP+NI FL K+GD G
Sbjct: 326 GLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHAT 385
Query: 257 ELGTAGAGEVQEGDPRYMAPELLQGSYG--TAADVFSLGLTILEVACNMELPHGGEGWQQ 314
+ +V+EGD R++A E+LQ Y AD+F+LGLTI A LP G W
Sbjct: 386 SINKP---KVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHH 442
Query: 315 LRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLR 360
+R+G P+ LS S+L M++PD + R +A AL VLR
Sbjct: 443 IRKGNF-PDVPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLR 487
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 112 bits (280), Expect = 7e-25
Identities = 83/206 (40%), Positives = 108/206 (52%), Gaps = 10/206 (4%)
Query: 102 PESFFQQSFQRLSRLGHGSYGEVFKVRSKED---GRLYAVK--RSMSPFRGPKDRARKLA 156
PE F+ L LG G YG+VF+VR + G++YA+K R R KD A A
Sbjct: 59 PERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRA 118
Query: 157 EVGSHEKVGQHPCCVRLEQAWEEGGILYLQTE-LCGPSLQQHCEAWGASLPEAQVWGYLR 215
E E V +HP V L A++ GG LYL E L G L H E G L + + YL
Sbjct: 119 ERNILESV-KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACF-YLA 176
Query: 216 DTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGA-GEVQEGDPRYM 274
+ LAL HLHSQG+++ D+KP NI L +G KL DFGL E GA G YM
Sbjct: 177 EITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYM 236
Query: 275 APELL-QGSYGTAADVFSLGLTILEV 299
APE+L + + A D +SLG + ++
Sbjct: 237 APEILVRSGHNRAVDWWSLGALMYDM 262
>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
Length = 1258
Score = 108 bits (271), Expect = 8e-24
Identities = 76/257 (29%), Positives = 126/257 (49%), Gaps = 15/257 (5%)
Query: 108 QSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQH 167
+ + RL ++G GS+G+ V+S EDGR Y +K K+R EV + +H
Sbjct: 2 EKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANM-KH 60
Query: 168 PCCVRLEQAWEEGGILYLQTELC-GPSLQQHCEAW-GASLPEAQVWGYLRDTLLALAHLH 225
P V+ +++EE G LY+ + C G L + A G E Q+ + LAL H+H
Sbjct: 61 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 120
Query: 226 SQGLVHLDVKPANIFLGPRGRCKLGDFGLLVEL-GTAGAGEVQEGDPRYMAPELLQGS-Y 283
+ ++H D+K NIFL G +LGDFG+ L T G P Y++PE+ + Y
Sbjct: 121 DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPY 180
Query: 284 GTAADVFSLGLTILEVACNMELPHGGEGWQ------QLRQGYLPPEFTAGLSSELRSVLV 337
+D+++LG + E+ L H E ++ G PP + S +LRS++
Sbjct: 181 NNKSDIWALGCVLYELC---TLKHAFEAGSMKNLVLKIISGSFPP-VSLHYSYDLRSLVS 236
Query: 338 MMLEPDPKLRATAEALL 354
+ + +P+ R + ++L
Sbjct: 237 QLFKRNPRDRPSVNSIL 253
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 107 bits (266), Expect = 3e-23
Identities = 83/265 (31%), Positives = 124/265 (46%), Gaps = 16/265 (6%)
Query: 110 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPC 169
+ L RLG G+YGEVFK R K G L A+K P D L + K +H
Sbjct: 17 YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKME---PDDDVSTLQKEILILKTCRHAN 73
Query: 170 CVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGL 229
V ++ L++ E CG Q SL E Q+ R+ L LA+LHSQ
Sbjct: 74 IVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKK 133
Query: 230 VHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQ-EGDPRYMAPEL----LQGSYG 284
+H D+K ANI + G +L DFG+ ++G A + G P +MAPE+ L+G Y
Sbjct: 134 IHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYN 193
Query: 285 TAADVFSLGLTILEVACNMELPHGGEG-----WQQLRQGYLPPEF--TAGLSSELRSVLV 337
D++SLG+T +E+A ++ P + + GY PP S+ + +
Sbjct: 194 ELCDIWSLGITAIELA-ELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIK 252
Query: 338 MMLEPDPKLRATAEALLALPVLRQP 362
+ L PK R +A +L+ ++ QP
Sbjct: 253 VTLTKSPKKRPSATKMLSHQLVSQP 277
>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
isoform 2 [Homo sapiens]
Length = 833
Score = 107 bits (266), Expect = 3e-23
Identities = 83/265 (31%), Positives = 124/265 (46%), Gaps = 16/265 (6%)
Query: 110 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPC 169
+ L RLG G+YGEVFK R K G L A+K P D L + K +H
Sbjct: 17 YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKME---PDDDVSTLQKEILILKTCRHAN 73
Query: 170 CVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGL 229
V ++ L++ E CG Q SL E Q+ R+ L LA+LHSQ
Sbjct: 74 IVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKK 133
Query: 230 VHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQ-EGDPRYMAPEL----LQGSYG 284
+H D+K ANI + G +L DFG+ ++G A + G P +MAPE+ L+G Y
Sbjct: 134 IHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYN 193
Query: 285 TAADVFSLGLTILEVACNMELPHGGEG-----WQQLRQGYLPPEF--TAGLSSELRSVLV 337
D++SLG+T +E+A ++ P + + GY PP S+ + +
Sbjct: 194 ELCDIWSLGITAIELA-ELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIK 252
Query: 338 MMLEPDPKLRATAEALLALPVLRQP 362
+ L PK R +A +L+ ++ QP
Sbjct: 253 VTLTKSPKKRPSATKMLSHQLVSQP 277
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 106 bits (264), Expect = 5e-23
Identities = 85/279 (30%), Positives = 134/279 (48%), Gaps = 16/279 (5%)
Query: 94 SPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRAR 153
+PG+D SR Q+ F+ + R+G G+YG+V+K R+ G L A+K + +D A
Sbjct: 2 NPGFDLSRRNP--QEDFELIQRIGSGTYGDVYKARNVNTGELAAIK--VIKLEPGEDFAV 57
Query: 154 KLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGY 213
E+ K +HP V ++ L++ E CG Q L E Q+
Sbjct: 58 VQQEI-IMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYV 116
Query: 214 LRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVEL-GTAGAGEVQEGDPR 272
R+TL L +LHS+G +H D+K ANI L G KL DFG+ ++ T + G P
Sbjct: 117 SRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY 176
Query: 273 YMAPELL----QGSYGTAADVFSLGLTILEVA----CNMELPHGGEGWQQLRQGYLPPEF 324
+MAPE+ +G Y D++++G+T +E+A +L + + + PP+
Sbjct: 177 WMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKL 236
Query: 325 TAGL--SSELRSVLVMMLEPDPKLRATAEALLALPVLRQ 361
+ S+ + M L +PK R TAE LL P + Q
Sbjct: 237 KDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQ 275
>gi|41872374 polo-like kinase 3 [Homo sapiens]
Length = 646
Score = 103 bits (258), Expect = 3e-22
Identities = 97/330 (29%), Positives = 140/330 (42%), Gaps = 33/330 (10%)
Query: 36 EPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQS- 94
EP PR R+ P P G P PP + RG E L
Sbjct: 2 EPAAGFLSPRPFQRAAAAPAPPAGPGP-----PPS------------ALRGPELEMLAGL 44
Query: 95 PGYDPSR----PESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKR-SMSPFRGPK 149
P DP R P S +++ + LG G + ++ E G YAVK S P
Sbjct: 45 PTSDPGRLITDPRS--GRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPH 102
Query: 150 DRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQ 209
R + L E+ H + QH VR +E+ +Y+ ELC H +L E +
Sbjct: 103 QREKILNEIELHRDL-QHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPE 161
Query: 210 VWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQE- 268
V YLR L L +LH +G++H D+K N F+ K+GDFGL L +
Sbjct: 162 VRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTIC 221
Query: 269 GDPRYMAPE-LLQGSYGTAADVFSLGLTILEVACN---MELPHGGEGWQQLRQGYLPPEF 324
G P Y+APE LL+ +G ADV+SLG + + C E E ++ ++Q +
Sbjct: 222 GTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHY--TL 279
Query: 325 TAGLSSELRSVLVMMLEPDPKLRATAEALL 354
A LS R +L +L P+ R + + +L
Sbjct: 280 PASLSLPARQLLAAILRASPRDRPSIDQIL 309
>gi|55956904 mitogen-activated protein kinase kinase kinase 4 isoform
a [Homo sapiens]
Length = 1608
Score = 103 bits (256), Expect = 5e-22
Identities = 92/290 (31%), Positives = 133/290 (45%), Gaps = 21/290 (7%)
Query: 80 RRVSFRGEASETLQSPGYDPSRPESFFQQSF--QRLSRLGHGSYGEVFKVRSKEDGRLYA 137
RR + G+ +T +S YD + +F QR +++G G YG+V+ S + G L A
Sbjct: 1313 RRKNIIGQVCDTPKS--YDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMA 1370
Query: 138 VKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQH 197
+K K E+ E + +HP VR +Y+ E C +
Sbjct: 1371 MKEIRFQPNDHKTIKETADELKIFEGI-KHPNLVRYFGVELHREEMYIFMEYCDEGTLEE 1429
Query: 198 CEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVE 257
G L E + Y + +A+ LH G+VH D+K ANIFL G KLGDFG V+
Sbjct: 1430 VSRLG--LQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVK 1487
Query: 258 L---GTAGAGEVQE--GDPRYMAPELLQGS----YGTAADVFSLGLTILEVACNM----E 304
L GEV G YMAPE++ + +G AAD++SLG ++E+ E
Sbjct: 1488 LKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHE 1547
Query: 305 LPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALL 354
H + ++ G+ PP LS E + L LE DPK+R TA LL
Sbjct: 1548 YEHNFQIMYKVGMGHKPP-IPERLSPEGKDFLSHCLESDPKMRWTASQLL 1596
>gi|55956902 mitogen-activated protein kinase kinase kinase 4 isoform
b [Homo sapiens]
Length = 1558
Score = 103 bits (256), Expect = 5e-22
Identities = 92/290 (31%), Positives = 133/290 (45%), Gaps = 21/290 (7%)
Query: 80 RRVSFRGEASETLQSPGYDPSRPESFFQQSF--QRLSRLGHGSYGEVFKVRSKEDGRLYA 137
RR + G+ +T +S YD + +F QR +++G G YG+V+ S + G L A
Sbjct: 1263 RRKNIIGQVCDTPKS--YDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMA 1320
Query: 138 VKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQH 197
+K K E+ E + +HP VR +Y+ E C +
Sbjct: 1321 MKEIRFQPNDHKTIKETADELKIFEGI-KHPNLVRYFGVELHREEMYIFMEYCDEGTLEE 1379
Query: 198 CEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVE 257
G L E + Y + +A+ LH G+VH D+K ANIFL G KLGDFG V+
Sbjct: 1380 VSRLG--LQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVK 1437
Query: 258 L---GTAGAGEVQE--GDPRYMAPELLQGS----YGTAADVFSLGLTILEVACNM----E 304
L GEV G YMAPE++ + +G AAD++SLG ++E+ E
Sbjct: 1438 LKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHE 1497
Query: 305 LPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALL 354
H + ++ G+ PP LS E + L LE DPK+R TA LL
Sbjct: 1498 YEHNFQIMYKVGMGHKPP-IPERLSPEGKDFLSHCLESDPKMRWTASQLL 1546
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 102 bits (254), Expect = 8e-22
Identities = 83/223 (37%), Positives = 115/223 (51%), Gaps = 19/223 (8%)
Query: 87 EASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRS---KEDGRLYAVK--RS 141
E SET + G + RPE F + L LG G YG+VF+VR G+++A+K +
Sbjct: 73 EISETSVNRGPEKIRPECF-----ELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKK 127
Query: 142 MSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTE-LCGPSLQQHCEA 200
R KD A AE E+V +HP V L A++ GG LYL E L G L E
Sbjct: 128 AMIVRNAKDTAHTKAERNILEEV-KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLER 186
Query: 201 WGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGT 260
G + + + YL + +AL HLH +G+++ D+KP NI L +G KL DFGL E +
Sbjct: 187 EGIFMEDTACF-YLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKE--S 243
Query: 261 AGAGEVQE---GDPRYMAPELLQGS-YGTAADVFSLGLTILEV 299
G V G YMAPE+L S + A D +SLG + ++
Sbjct: 244 IHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDM 286
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 101 bits (251), Expect = 2e-21
Identities = 90/271 (33%), Positives = 130/271 (47%), Gaps = 22/271 (8%)
Query: 110 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPC 169
F+ L R+G G+YG+V+K R L AVK P D L + + + +HP
Sbjct: 16 FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLD---PGDDISSLQQEITILRECRHPN 72
Query: 170 CVRLEQAWEEGGILYLQTELCGP-SLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQG 228
V ++ L++ E CG SLQ+ A G L E Q+ R+ L L HLHSQG
Sbjct: 73 VVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGP-LEERQIAYVCREALKGLHHLHSQG 131
Query: 229 LVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQE--GDPRYMAPELL----QGS 282
+H D+K AN+ L +G KL DFG+ EL TA + + G P +MAPE+ +G
Sbjct: 132 KIHRDIKGANLLLTLQGDVKLADFGVSGEL-TASVAKRRSFIGTPYWMAPEVAAVERKGG 190
Query: 283 YGTAADVFSLGLTILEVACNMELP----HGGEGWQQL-RQGYLPPEF--TAGLSSELRSV 335
Y DV++LG+T +E+ ++ P H + + + PP+ +
Sbjct: 191 YNELCDVWALGITAIELG-ELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHF 249
Query: 336 LVMMLEPDPKLRATAEALLALPVLRQ--PRA 364
L + L +PK R TAE LL P Q PRA
Sbjct: 250 LKLALTKNPKKRPTAEKLLQHPFTTQQLPRA 280
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 101 bits (251), Expect = 2e-21
Identities = 72/256 (28%), Positives = 122/256 (47%), Gaps = 12/256 (4%)
Query: 113 LSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVR 172
+ +G G++G+ + + K D + +K +++ EV EK+ +HP V
Sbjct: 7 IKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKM-KHPNIVA 65
Query: 173 LEQAWEEGGILYLQTELC--GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLV 230
+++E G L++ E C G +++ G E Q+ G+ L L H+H + ++
Sbjct: 66 FFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIHDRKIL 125
Query: 231 HLDVKPANIFLGPRGR-CKLGDFGLLVELGTA-GAGEVQEGDPRYMAPELLQGS-YGTAA 287
H D+K NIFL G KLGDFG+ L + G P Y++PE+ Q Y
Sbjct: 126 HRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKPYNNKT 185
Query: 288 DVFSLGLTILEVACNMELPHGGEGWQQL----RQGYLPPEFTAGLSSELRSVLVMMLEPD 343
D++SLG + E+ C ++ P G QQL Q + P + G S EL S++ + +
Sbjct: 186 DIWSLGCVLYEL-CTLKHPFEGNNLQQLVLKICQAHFAP-ISPGFSRELHSLISQLFQVS 243
Query: 344 PKLRATAEALLALPVL 359
P+ R + ++L P L
Sbjct: 244 PRDRPSINSILKRPFL 259
>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
Length = 841
Score = 100 bits (248), Expect = 4e-21
Identities = 80/259 (30%), Positives = 125/259 (48%), Gaps = 20/259 (7%)
Query: 116 LGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQ--HPCCVRL 173
+G GSYGEV V+ + DG+ Y +K+ R R R+ AE + + + Q HP V
Sbjct: 12 VGKGSYGEVTLVKHRRDGKQYVIKKLN--LRNASSRERRAAEQEA-QLLSQLKHPNIVTY 68
Query: 174 EQAWEEG-GILYLQTELC--GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLV 230
+++WE G G+LY+ C G ++ E G LPE QV + +AL +LH + ++
Sbjct: 69 KESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHIL 128
Query: 231 HLDVKPANIFLGPRGRCKLGDFGLLVEL-GTAGAGEVQEGDPRYMAPELLQGS-YGTAAD 288
H D+K N+FL K+GD G+ L G P YM+PEL Y +D
Sbjct: 129 HRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKSD 188
Query: 289 VFSLGLTILEVACNMELPHGGEGWQ------QLRQGYLPPEFTAGLSSELRSVLVMMLEP 342
V++LG + E+A L H ++ +G LPP S EL ++ ML
Sbjct: 189 VWALGCCVYEMA---TLKHAFNAKDMNSLVYRIIEGKLPP-MPRDYSPELAELIRTMLSK 244
Query: 343 DPKLRATAEALLALPVLRQ 361
P+ R + ++L P +++
Sbjct: 245 RPEERPSVRSILRQPYIKR 263
>gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Homo
sapiens]
Length = 1288
Score = 99.8 bits (247), Expect = 5e-21
Identities = 84/257 (32%), Positives = 125/257 (48%), Gaps = 15/257 (5%)
Query: 116 LGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQ 175
LG G+YG V+ R + A+K P R + E+ H ++ +H VR
Sbjct: 654 LGKGTYGVVYAGRDRHTRVRIAIKEI--PERDSRFSQPLHEEIALHRRL-RHKNIVRYLG 710
Query: 176 AWEEGGILYL-QTELCGPSLQQHCEA-WGASLP-EAQVWGYLRDTLLALAHLHSQGLVHL 232
+ +GG L + E+ G SL + WG E+ + Y R L L +LH +VH
Sbjct: 711 SASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHR 770
Query: 233 DVKPANIFLGP-RGRCKLGDFGLLVEL-GTAGAGEVQEGDPRYMAPELL-QG--SYGTAA 287
D+K N+ + G K+ DFG L G E G +YMAPE++ QG YG AA
Sbjct: 771 DIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAA 830
Query: 288 DVFSLGLTILEVACNM----ELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPD 343
D++SLG T++E+A EL Q+ + P + LS+E ++ L+ EPD
Sbjct: 831 DIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPD 890
Query: 344 PKLRATAEALLALPVLR 360
P+LRA+A+ LL P L+
Sbjct: 891 PRLRASAQTLLGDPFLQ 907
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 99.8 bits (247), Expect = 5e-21
Identities = 81/287 (28%), Positives = 125/287 (43%), Gaps = 35/287 (12%)
Query: 110 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPC 169
FQ++ ++G G+YG V+K +++E G+L A+K+ + + E+ +++ +HP
Sbjct: 4 FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKEL-KHPN 62
Query: 170 CVRLEQAWEEGGILYLQTELCGPSLQQHCEAW-GASLPEAQVWGYLRDTLLALAHLHSQG 228
VRL LYL E L+++ ++ G+ LP + YL L ++ HS
Sbjct: 63 IVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHR 122
Query: 229 LVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPR-YMAPELLQGS--YGT 285
++H D+KP N+ + G KL DFGL G E Y APE+L GS Y T
Sbjct: 123 VIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTT 182
Query: 286 AADVFSLGLTILEVACNMELPHGGEGWQQL-----------------------RQGYLP- 321
A D++S+G E+ L G QL +G P
Sbjct: 183 AVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPK 242
Query: 322 ------PEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQP 362
E L E R +L+ +L+ DP R TA+ LA P P
Sbjct: 243 WTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSP 289
>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
Length = 489
Score = 99.0 bits (245), Expect = 9e-21
Identities = 73/256 (28%), Positives = 124/256 (48%), Gaps = 22/256 (8%)
Query: 113 LSRLGHGSYGEVFKVRSKEDGRLYAVK-----RSMSPFRGPKDRARKLAEVGSHEKVGQH 167
L +G GS+G V+ + +++A+K +S S + + A LA++ +H
Sbjct: 7 LRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKM-------KH 59
Query: 168 PCCVRLEQAWEEGGILYLQTELC--GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLH 225
P V ++++E G LY+ E C G +Q+ + G PE + + L + H+H
Sbjct: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
Query: 226 SQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGA-GEVQEGDPRYMAPELLQG-SY 283
+ ++H D+K NIFL G+ KLGDFG L A G P Y+ PE+ + Y
Sbjct: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
Query: 284 GTAADVFSLGLTILEVACNMELPHGGEGWQQL----RQGYLPPEFTAGLSSELRSVLVMM 339
+D++SLG + E+ C ++ P W+ L QG + P + S EL+ ++ M
Sbjct: 180 NNKSDIWSLGCILYEL-CTLKHPFQANSWKNLILKVCQGCISP-LPSHYSYELQFLVKQM 237
Query: 340 LEPDPKLRATAEALLA 355
+ +P R +A LL+
Sbjct: 238 FKRNPSHRPSATTLLS 253
>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 99.0 bits (245), Expect = 9e-21
Identities = 73/256 (28%), Positives = 124/256 (48%), Gaps = 22/256 (8%)
Query: 113 LSRLGHGSYGEVFKVRSKEDGRLYAVK-----RSMSPFRGPKDRARKLAEVGSHEKVGQH 167
L +G GS+G V+ + +++A+K +S S + + A LA++ +H
Sbjct: 7 LRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKM-------KH 59
Query: 168 PCCVRLEQAWEEGGILYLQTELC--GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLH 225
P V ++++E G LY+ E C G +Q+ + G PE + + L + H+H
Sbjct: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
Query: 226 SQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGA-GEVQEGDPRYMAPELLQG-SY 283
+ ++H D+K NIFL G+ KLGDFG L A G P Y+ PE+ + Y
Sbjct: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
Query: 284 GTAADVFSLGLTILEVACNMELPHGGEGWQQL----RQGYLPPEFTAGLSSELRSVLVMM 339
+D++SLG + E+ C ++ P W+ L QG + P + S EL+ ++ M
Sbjct: 180 NNKSDIWSLGCILYEL-CTLKHPFQANSWKNLILKVCQGCISP-LPSHYSYELQFLVKQM 237
Query: 340 LEPDPKLRATAEALLA 355
+ +P R +A LL+
Sbjct: 238 FKRNPSHRPSATTLLS 253
>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 99.0 bits (245), Expect = 9e-21
Identities = 73/256 (28%), Positives = 124/256 (48%), Gaps = 22/256 (8%)
Query: 113 LSRLGHGSYGEVFKVRSKEDGRLYAVK-----RSMSPFRGPKDRARKLAEVGSHEKVGQH 167
L +G GS+G V+ + +++A+K +S S + + A LA++ +H
Sbjct: 7 LRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKM-------KH 59
Query: 168 PCCVRLEQAWEEGGILYLQTELC--GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLH 225
P V ++++E G LY+ E C G +Q+ + G PE + + L + H+H
Sbjct: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
Query: 226 SQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGA-GEVQEGDPRYMAPELLQG-SY 283
+ ++H D+K NIFL G+ KLGDFG L A G P Y+ PE+ + Y
Sbjct: 120 KKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPY 179
Query: 284 GTAADVFSLGLTILEVACNMELPHGGEGWQQL----RQGYLPPEFTAGLSSELRSVLVMM 339
+D++SLG + E+ C ++ P W+ L QG + P + S EL+ ++ M
Sbjct: 180 NNKSDIWSLGCILYEL-CTLKHPFQANSWKNLILKVCQGCISP-LPSHYSYELQFLVKQM 237
Query: 340 LEPDPKLRATAEALLA 355
+ +P R +A LL+
Sbjct: 238 FKRNPSHRPSATTLLS 253
>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
Length = 302
Score = 97.4 bits (241), Expect = 2e-20
Identities = 78/283 (27%), Positives = 134/283 (47%), Gaps = 25/283 (8%)
Query: 87 EASETLQSPGYDPSRPESFFQQ--------SFQRLSRLGHGSYGEVFKVRSKEDGRLYAV 138
E S+ +Q P +P+ + +F+ ++G G + EV++ DG A+
Sbjct: 3 EQSQGMQGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVAL 62
Query: 139 KR-SMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPS---- 193
K+ + K RA + E+ +++ HP ++ ++ E L + EL
Sbjct: 63 KKVQIFDLMDAKARADCIKEIDLLKQLN-HPNVIKYYASFIEDNELNIVLELADAGDLSR 121
Query: 194 LQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFG 253
+ +H + +PE VW Y AL H+HS+ ++H D+KPAN+F+ G KLGD G
Sbjct: 122 MIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLG 181
Query: 254 L--LVELGTAGAGEVQEGDPRYMAPELL-QGSYGTAADVFSLGLTILEVACNMELPHGGE 310
L T A + G P YM+PE + + Y +D++SLG + E+A ++ P G+
Sbjct: 182 LGRFFSSKTTAAHSL-VGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAA-LQSPFYGD 239
Query: 311 GW------QQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLR 347
+++ Q PP + S ELR ++ M + PDP+ R
Sbjct: 240 KMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKR 282
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 97.1 bits (240), Expect = 3e-20
Identities = 82/283 (28%), Positives = 130/283 (45%), Gaps = 17/283 (6%)
Query: 107 QQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQ 166
QQ ++ + R+G G+YG+V+K R+ G L AVK P D + + K +
Sbjct: 17 QQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE---PGDDFSLIQQEIFMVKECK 73
Query: 167 HPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHS 226
H V ++ L++ E CG Q L E Q+ R+TL LA+LH+
Sbjct: 74 HCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHT 133
Query: 227 QGLVHLDVKPANIFLGPRGRCKLGDFGLLVEL-GTAGAGEVQEGDPRYMAPELL----QG 281
+G +H D+K ANI L G KL DFG+ ++ T + G P +MAPE+ G
Sbjct: 134 KGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNG 193
Query: 282 SYGTAADVFSLGLTILEVA----CNMELPHGGEGWQQLRQGYLPPEF--TAGLSSELRSV 335
Y D++++G+T +E+ +L + + + PP+ SS +
Sbjct: 194 GYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNF 253
Query: 336 LVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSR 378
+ + L +PK R TAE LL + QP G+ +A E L +
Sbjct: 254 VKIALTKNPKKRPTAERLLTHTFVAQP---GLSRALAVELLDK 293
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 97.1 bits (240), Expect = 3e-20
Identities = 82/283 (28%), Positives = 130/283 (45%), Gaps = 17/283 (6%)
Query: 107 QQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQ 166
QQ ++ + R+G G+YG+V+K R+ G L AVK P D + + K +
Sbjct: 17 QQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE---PGDDFSLIQQEIFMVKECK 73
Query: 167 HPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHS 226
H V ++ L++ E CG Q L E Q+ R+TL LA+LH+
Sbjct: 74 HCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHT 133
Query: 227 QGLVHLDVKPANIFLGPRGRCKLGDFGLLVEL-GTAGAGEVQEGDPRYMAPELL----QG 281
+G +H D+K ANI L G KL DFG+ ++ T + G P +MAPE+ G
Sbjct: 134 KGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNG 193
Query: 282 SYGTAADVFSLGLTILEVA----CNMELPHGGEGWQQLRQGYLPPEF--TAGLSSELRSV 335
Y D++++G+T +E+ +L + + + PP+ SS +
Sbjct: 194 GYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNF 253
Query: 336 LVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSR 378
+ + L +PK R TAE LL + QP G+ +A E L +
Sbjct: 254 VKIALTKNPKKRPTAERLLTHTFVAQP---GLSRALAVELLDK 293
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 96.3 bits (238), Expect = 6e-20
Identities = 81/280 (28%), Positives = 131/280 (46%), Gaps = 18/280 (6%)
Query: 107 QQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQ 166
++ F L +LG GSYG VFK KE G++ A+K+ D + E+ ++
Sbjct: 24 EEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE----SDLQEIIKEISIMQQCDS 79
Query: 167 HPCCVRLEQAWEEGGILYLQTELCGP-SLQQHCEAWGASLPEAQVWGYLRDTLLALAHLH 225
P V+ ++ + L++ E CG S+ +L E ++ L+ TL L +LH
Sbjct: 80 -PYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLH 138
Query: 226 SQGLVHLDVKPANIFLGPRGRCKLGDFGLLVEL-GTAGAGEVQEGDPRYMAPELLQG-SY 283
+H D+K NI L G KL DFG+ +L T G P +MAPE++Q Y
Sbjct: 139 FMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGY 198
Query: 284 GTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYL-----PPEFTAG--LSSELRSVL 336
AD++SLG+T +E+A + P+ +R ++ PP F S + +
Sbjct: 199 NCVADIWSLGITSIEMA-EGKPPYA--DIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFV 255
Query: 337 VMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEAL 376
L +P+ RATA LL P ++ + +L + EA+
Sbjct: 256 KKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAM 295
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 95.1 bits (235), Expect = 1e-19
Identities = 81/280 (28%), Positives = 129/280 (46%), Gaps = 18/280 (6%)
Query: 107 QQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQ 166
++ F L +LG GSYG V+K KE G++ A+K+ D + E+ ++
Sbjct: 27 EEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE----SDLQEIIKEISIMQQCDS 82
Query: 167 HPCCVRLEQAWEEGGILYLQTELCGP-SLQQHCEAWGASLPEAQVWGYLRDTLLALAHLH 225
P V+ ++ + L++ E CG S+ +L E ++ L+ TL L +LH
Sbjct: 83 -PHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLH 141
Query: 226 SQGLVHLDVKPANIFLGPRGRCKLGDFGLLVEL-GTAGAGEVQEGDPRYMAPELLQG-SY 283
+H D+K NI L G KL DFG+ +L T G P +MAPE++Q Y
Sbjct: 142 FMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGY 201
Query: 284 GTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYL-----PPEFTAG--LSSELRSVL 336
AD++SLG+T +E+A + P+ +R ++ PP F S +
Sbjct: 202 NCVADIWSLGITAIEMA-EGKPPYA--DIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFV 258
Query: 337 VMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEAL 376
L P+ RATA LL P +R + +L + EA+
Sbjct: 259 KQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAM 298
>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
Length = 347
Score = 93.6 bits (231), Expect = 4e-19
Identities = 89/339 (26%), Positives = 144/339 (42%), Gaps = 43/339 (12%)
Query: 30 AYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIP-------ISRLFPPRTPGWHQLQPRRV 82
A+FR E R R L R G +P + P P Q P +
Sbjct: 11 AHFRQEEQSLPRPRVRALVRLACRMAGQPGHMPHGGSSNNLCHTLGPVHPPDPQRHPNTL 70
Query: 83 SFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKR-S 141
SFR ++ FQ ++G G + EV+K D + A+K+
Sbjct: 71 SFRCSLAD-------------------FQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQ 111
Query: 142 MSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPS----LQQH 197
+ K R + E+G +++ HP ++ ++ E L + EL + ++
Sbjct: 112 IFEMMDAKARQDCVKEIGLLKQLN-HPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKY 170
Query: 198 CEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGL--L 255
+ +PE VW Y A+ H+HS+ ++H D+KPAN+F+ G KLGD GL
Sbjct: 171 FKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRF 230
Query: 256 VELGTAGAGEVQEGDPRYMAPELL-QGSYGTAADVFSLGLTILEVACNMELPHGGEGW-- 312
T A + G P YM+PE + + Y +D++SLG + E+A ++ P G+
Sbjct: 231 FSSETTAAHSL-VGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAA-LQSPFYGDKMNL 288
Query: 313 ----QQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLR 347
Q++ Q PP S +LR ++ M + PDP R
Sbjct: 289 FSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPDPHQR 327
>gi|4759208 TAO kinase 2 isoform 1 [Homo sapiens]
Length = 1049
Score = 93.2 bits (230), Expect = 5e-19
Identities = 75/271 (27%), Positives = 118/271 (43%), Gaps = 20/271 (7%)
Query: 98 DPSRPESFFQQS----FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRAR 153
DP E FF+ F L +GHGS+G V+ R + + A+K+ + ++ +
Sbjct: 12 DPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQ 71
Query: 154 KLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGY 213
+ + + +HP ++ + +L E C S E L E ++
Sbjct: 72 DIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAV 131
Query: 214 LRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRY 273
L LA+LHS ++H DVK NI L G KLGDFG + A + G P +
Sbjct: 132 THGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANS---FVGTPYW 188
Query: 274 MAPELL----QGSYGTAADVFSLGLTILEVA------CNMELPHGGEGWQQLRQGYLPPE 323
MAPE++ +G Y DV+SLG+T +E+A NM + + Q P
Sbjct: 189 MAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNM---NAMSALYHIAQNESPVL 245
Query: 324 FTAGLSSELRSVLVMMLEPDPKLRATAEALL 354
+ S R+ + L+ P+ R T+E LL
Sbjct: 246 QSGHWSEYFRNFVDSCLQKIPQDRPTSEVLL 276
>gi|45505130 TAO kinase 2 isoform 2 [Homo sapiens]
Length = 1235
Score = 93.2 bits (230), Expect = 5e-19
Identities = 75/271 (27%), Positives = 118/271 (43%), Gaps = 20/271 (7%)
Query: 98 DPSRPESFFQQS----FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRAR 153
DP E FF+ F L +GHGS+G V+ R + + A+K+ + ++ +
Sbjct: 12 DPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQ 71
Query: 154 KLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGY 213
+ + + +HP ++ + +L E C S E L E ++
Sbjct: 72 DIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAV 131
Query: 214 LRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRY 273
L LA+LHS ++H DVK NI L G KLGDFG + A + G P +
Sbjct: 132 THGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANS---FVGTPYW 188
Query: 274 MAPELL----QGSYGTAADVFSLGLTILEVA------CNMELPHGGEGWQQLRQGYLPPE 323
MAPE++ +G Y DV+SLG+T +E+A NM + + Q P
Sbjct: 189 MAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNM---NAMSALYHIAQNESPVL 245
Query: 324 FTAGLSSELRSVLVMMLEPDPKLRATAEALL 354
+ S R+ + L+ P+ R T+E LL
Sbjct: 246 QSGHWSEYFRNFVDSCLQKIPQDRPTSEVLL 276
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.139 0.462
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,818,007
Number of Sequences: 37866
Number of extensions: 1737847
Number of successful extensions: 13864
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 603
Number of HSP's successfully gapped in prelim test: 609
Number of HSP's that attempted gapping in prelim test: 9328
Number of HSP's gapped (non-prelim): 3931
length of query: 480
length of database: 18,247,518
effective HSP length: 106
effective length of query: 374
effective length of database: 14,233,722
effective search space: 5323412028
effective search space used: 5323412028
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.