Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 31881740
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31881740 solute carrier family 12 (potassium/chloride
transporters), member 9 [Homo sapiens]
(914 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31881740 solute carrier family 12 (potassium/chloride transpo... 1811 0.0
gi|4506975 solute carrier family 12 (sodium/potassium/chloride t... 286 6e-77
gi|134254459 sodium potassium chloride cotransporter 2 [Homo sap... 278 2e-74
gi|225579067 solute carrier family 12, member 4 isoform e [Homo ... 264 3e-70
gi|225579065 solute carrier family 12, member 4 isoform d [Homo ... 264 3e-70
gi|225579063 solute carrier family 12, member 4 isoform c [Homo ... 264 3e-70
gi|4827006 solute carrier family 12, member 4 isoform a [Homo sa... 264 3e-70
gi|225579061 solute carrier family 12, member 4 isoform b [Homo ... 262 9e-70
gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo ... 248 1e-65
gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo ... 248 1e-65
gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo ... 248 1e-65
gi|123701900 solute carrier family 12 (potassium/chloride transp... 197 4e-50
gi|110224458 solute carrier family 12, member 6 isoform e [Homo ... 195 1e-49
gi|110224456 solute carrier family 12, member 6 isoform d [Homo ... 195 1e-49
gi|110224454 solute carrier family 12, member 6 isoform c [Homo ... 195 1e-49
gi|110224452 solute carrier family 12, member 6 isoform c [Homo ... 195 1e-49
gi|4826780 solute carrier family 12, member 6 isoform b [Homo sa... 195 1e-49
gi|110224449 solute carrier family 12, member 6 isoform a [Homo ... 195 1e-49
gi|198041678 solute carrier family 12 (potassium-chloride transp... 193 7e-49
gi|11968148 solute carrier family 12 (potassium-chloride transpo... 193 7e-49
gi|38569457 solute carrier family 12, member 8 [Homo sapiens] 185 1e-46
gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo s... 49 3e-05
gi|114326550 solute carrier family 7 (cationic amino acid transp... 48 4e-05
gi|114326544 solute carrier family 7 (cationic amino acid transp... 48 4e-05
gi|4507047 solute carrier family 7 (cationic amino acid transpor... 47 8e-05
gi|110347453 solute carrier family 7 (cationic amino acid transp... 41 0.006
gi|14110420 heterogeneous nuclear ribonucleoprotein D isoform a ... 38 0.049
gi|14110414 heterogeneous nuclear ribonucleoprotein D isoform c ... 38 0.049
gi|14110417 heterogeneous nuclear ribonucleoprotein D isoform b ... 38 0.049
gi|51477708 heterogeneous nuclear ribonucleoprotein D isoform d ... 38 0.049
>gi|31881740 solute carrier family 12 (potassium/chloride
transporters), member 9 [Homo sapiens]
Length = 914
Score = 1811 bits (4690), Expect = 0.0
Identities = 914/914 (100%), Positives = 914/914 (100%)
Query: 1 MASESSPLLAYRLLGEEGVALPANGAGGPGGASARKLSTFLGVVVPTVLSMFSIVVFLRI 60
MASESSPLLAYRLLGEEGVALPANGAGGPGGASARKLSTFLGVVVPTVLSMFSIVVFLRI
Sbjct: 1 MASESSPLLAYRLLGEEGVALPANGAGGPGGASARKLSTFLGVVVPTVLSMFSIVVFLRI 60
Query: 61 GFVVGHAGLLQALAMLLVAYFILALTVLSVCAIATNGAVQGGGAYFMISRTLGPEVGGSI 120
GFVVGHAGLLQALAMLLVAYFILALTVLSVCAIATNGAVQGGGAYFMISRTLGPEVGGSI
Sbjct: 61 GFVVGHAGLLQALAMLLVAYFILALTVLSVCAIATNGAVQGGGAYFMISRTLGPEVGGSI 120
Query: 121 GLMFYLANVCGCAVSLLGLVESVLDVFGADATGPSGLRVLPQGYGWNLLYGSLLLGLVGG 180
GLMFYLANVCGCAVSLLGLVESVLDVFGADATGPSGLRVLPQGYGWNLLYGSLLLGLVGG
Sbjct: 121 GLMFYLANVCGCAVSLLGLVESVLDVFGADATGPSGLRVLPQGYGWNLLYGSLLLGLVGG 180
Query: 181 VCTLGAGLYARASFLTFLLVSGSLASVLISFVAVGPRDIRLTPRPGPNGSSLPPRFGHFT 240
VCTLGAGLYARASFLTFLLVSGSLASVLISFVAVGPRDIRLTPRPGPNGSSLPPRFGHFT
Sbjct: 181 VCTLGAGLYARASFLTFLLVSGSLASVLISFVAVGPRDIRLTPRPGPNGSSLPPRFGHFT 240
Query: 241 GFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPL 300
GFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPL
Sbjct: 241 GFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPL 300
Query: 301 GTIVAVAYTFFVYVLLFFLSSFTCDRTLLQEDYGFFRAISLWPPLVLIGIYATALSASMS 360
GTIVAVAYTFFVYVLLFFLSSFTCDRTLLQEDYGFFRAISLWPPLVLIGIYATALSASMS
Sbjct: 301 GTIVAVAYTFFVYVLLFFLSSFTCDRTLLQEDYGFFRAISLWPPLVLIGIYATALSASMS 360
Query: 361 SLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAV 420
SLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAV
Sbjct: 361 SLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAV 420
Query: 421 VTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGG 480
VTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGG
Sbjct: 421 VTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGG 480
Query: 481 SLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLLVGN 540
SLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLLVGN
Sbjct: 481 SLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLLVGN 540
Query: 541 PRGALPLLRLANQLKKGGLYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDRAQVKAFVDL 600
PRGALPLLRLANQLKKGGLYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDRAQVKAFVDL
Sbjct: 541 PRGALPLLRLANQLKKGGLYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDRAQVKAFVDL 600
Query: 601 TLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDPAFSEPADSTREGSSP 660
TLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDPAFSEPADSTREGSSP
Sbjct: 601 TLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDPAFSEPADSTREGSSP 660
Query: 661 ALSTLFPPPRAPGSPRALNPQDYVATVADALKMNKNVVLARASGALPPERLSRGSGGTSQ 720
ALSTLFPPPRAPGSPRALNPQDYVATVADALKMNKNVVLARASGALPPERLSRGSGGTSQ
Sbjct: 661 ALSTLFPPPRAPGSPRALNPQDYVATVADALKMNKNVVLARASGALPPERLSRGSGGTSQ 720
Query: 721 LHHVDVWPLNLLRPRGGPGYVDVCGLFLLQMATILGMVPAWHSARLRIFLCLGPREAPGA 780
LHHVDVWPLNLLRPRGGPGYVDVCGLFLLQMATILGMVPAWHSARLRIFLCLGPREAPGA
Sbjct: 721 LHHVDVWPLNLLRPRGGPGYVDVCGLFLLQMATILGMVPAWHSARLRIFLCLGPREAPGA 780
Query: 781 AEGRLRALLSQLRIRAEVQEVVWGEGAGAGEPEAEEEGDFVNSGRGDAEAEALARSANAL 840
AEGRLRALLSQLRIRAEVQEVVWGEGAGAGEPEAEEEGDFVNSGRGDAEAEALARSANAL
Sbjct: 781 AEGRLRALLSQLRIRAEVQEVVWGEGAGAGEPEAEEEGDFVNSGRGDAEAEALARSANAL 840
Query: 841 VRAQQGRGTGGGPGGPEGGDAEGPITALTFLYLPRPPADPARYPRYLALLETLTRDLGPT 900
VRAQQGRGTGGGPGGPEGGDAEGPITALTFLYLPRPPADPARYPRYLALLETLTRDLGPT
Sbjct: 841 VRAQQGRGTGGGPGGPEGGDAEGPITALTFLYLPRPPADPARYPRYLALLETLTRDLGPT 900
Query: 901 LLVHGVTPVTCTDL 914
LLVHGVTPVTCTDL
Sbjct: 901 LLVHGVTPVTCTDL 914
>gi|4506975 solute carrier family 12 (sodium/potassium/chloride
transporters), member 2 [Homo sapiens]
Length = 1212
Score = 286 bits (732), Expect = 6e-77
Identities = 193/642 (30%), Positives = 336/642 (52%), Gaps = 77/642 (11%)
Query: 36 KLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIAT 95
K GV+V +L+++ +++F+R+ ++VG AG+ ++ ++++A + +T LS AIAT
Sbjct: 284 KFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIAT 343
Query: 96 NGAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLDVFGADATGPS 155
NG V+GGGAY++ISR+LGPE GG+IGL+F AN A+ ++G E+V+++ +
Sbjct: 344 NGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSI--- 400
Query: 156 GLRVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLI-SFVAV 214
++ + G++ + ++ G+ G A+A + +++ ++ +I +F+ +
Sbjct: 401 ---LMIDEINDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPL 457
Query: 215 GPRDIRLTPRPGPNGSSLPPRFGHFTGFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAVL 274
+ P G F G+ S +N G + E+ T F SVFA+
Sbjct: 458 ESKK--------PKG---------FFGYKSEIFNENFGPDFREEET------FFSVFAIF 494
Query: 275 FNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYV-------------------- 314
F TGI+AGAN+SG+L DP AIP GT++A+ T VYV
Sbjct: 495 FPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSCVVRDATGNVND 554
Query: 315 -LLFFLSSFTCDRTLLQED----------YGF---FRAISL---WPPLVLIGIYATALSA 357
++ L++ T L D YG F+ +S+ + PL+ GI++ LS+
Sbjct: 555 TIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLISAGIFSATLSS 614
Query: 358 SMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTL 417
+++SL+ A +I AL +D+++ AK + P + ++ + +L +LN +
Sbjct: 615 ALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVI 674
Query: 418 AAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGA 477
A +++ F+L +YA ++ S A +P +RP F ++ LLG C ++MF+I+ A
Sbjct: 675 APIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGAILCCIVMFVINWWA 734
Query: 478 AGGSLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLL 537
A + +++ L +T + +WG +QAL + ++ +RL +DHVK +RPQ L++
Sbjct: 735 ALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVM 794
Query: 538 VGNPRGALPLLRLANQLKKG-GLYVLGHVTLGD----LDSLPSDPVQPQYGAWLSLVDRA 592
G P LL L + K GL + GHV +G + + D Q +Y WL +
Sbjct: 795 TGAPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSID--QAKYQRWLI---KN 849
Query: 593 QVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDD 634
++KAF + +R+GAQ+L++ +GLG MKPNTLVLGF D
Sbjct: 850 KMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKD 891
>gi|134254459 sodium potassium chloride cotransporter 2 [Homo
sapiens]
Length = 1099
Score = 278 bits (710), Expect = 2e-74
Identities = 189/665 (28%), Positives = 330/665 (49%), Gaps = 92/665 (13%)
Query: 23 ANGAGGPGGASAR----------KLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQA 72
ANG G PG A K GV+V +L+++ +++F+R+ ++VG AG+
Sbjct: 153 ANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLG 212
Query: 73 LAMLLVAYFILALTVLSVCAIATNGAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGC 132
+ ++L++ + ++T LS AIATNG V+GGGAY++ISR+LGPE GGSIGL+F AN
Sbjct: 213 VLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAV 272
Query: 133 AVSLLGLVESVLDVFGADAT----GPSGLRVLPQGYGWNLLYGSLLLGLVGGVCTLGAGL 188
A+ ++G E+V+D+ + + +R++ GS+ + ++ G+ G
Sbjct: 273 AMYVVGFAETVVDLLKESDSMMVDPTNDIRII----------GSITVVILLGISVAGMEW 322
Query: 189 YARASFLTFLLVSGSLASVLISFVAVGPRDIRLTPRPGPNGSSLPPRFGHFTGFNSSTLK 248
A+A + +++ ++A+ I V P+ + R F + +S
Sbjct: 323 EAKAQVILLVILLIAIANFFIGTVI-------------PSNNEKKSR--GFFNYQASIFA 367
Query: 249 DNLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAY 308
+N G + + F SVFA+ F TGI+AGAN+SG+L+DP AIP GT++A+
Sbjct: 368 ENFGPRFTKGE------GFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFI 421
Query: 309 TFFVYVLLFF------------------LSSFTCDRTL-------------------LQE 331
T Y+ + +S C+ + L
Sbjct: 422 TTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMN 481
Query: 332 DYGFFRAISLWPPLVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAKVVSRG 391
++ +S + PL+ GI++ LS++++SL+ A ++ AL +D+++ + AK +
Sbjct: 482 NFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKN 541
Query: 392 GNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTF 451
P + ++ + +L +LNT+A +++ F+L +YA ++ SC +A +P +RP +
Sbjct: 542 NEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAY 601
Query: 452 SLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFH 511
+++ L G C +MF+I+ AA + ++ L +T + +WG +QAL +
Sbjct: 602 GIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYV 661
Query: 512 QVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGALPLLRLANQL-KKGGLYVLGHVTLGD- 569
L L +DHVK +RPQ ++L G P LL + + K GL + V +G
Sbjct: 662 SALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPR 721
Query: 570 ---LDSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNT 626
+ + S + Q AWL + ++KAF + R G + LL+ SGLG MKPNT
Sbjct: 722 KLCVKEMNSGMAKKQ--AWLI---KNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNT 776
Query: 627 LVLGF 631
LV+G+
Sbjct: 777 LVIGY 781
>gi|225579067 solute carrier family 12, member 4 isoform e [Homo
sapiens]
Length = 1054
Score = 264 bits (674), Expect = 3e-70
Identities = 251/868 (28%), Positives = 391/868 (45%), Gaps = 167/868 (19%)
Query: 32 ASARKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVC 91
A A + T +GV +P + ++F +++FLR+ ++VG AG+LQAL ++L+ LT +S+
Sbjct: 82 AEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMS 141
Query: 92 AIATNGAVQGGGAYFMISRTLGPEVGGSIGLMFYLAN-------VCGCAVSLLGLVESVL 144
AIATNG V GG+YFMISR+LGPE GG++GL FYL + G LL +
Sbjct: 142 AIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPA 201
Query: 145 DVF---GADATGPSGLRVLPQGYGWNLL----------------YGSLLLGLV------- 178
+F GA T + L + + YG L + SL L V
Sbjct: 202 AIFYPSGAHDTSNATLNNM-RVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSI 260
Query: 179 --GG-----------VCTLGAGLYARASF----LTFLLVSGSLASVLISFVAVGPRDIRL 221
GG VC LG +R F T ++ + ++A+ L SF P
Sbjct: 261 YAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTD 320
Query: 222 TPRPG---PNGSSLPPRFGHFTGFNSSTLKDNLGAGYAE--------------------D 258
+ P N + +P G + L++NL + Y E
Sbjct: 321 SCDPYFMLNNVTEIPG----IPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKES 376
Query: 259 YTTGAVMNFASVFAVL----FNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYV 314
V + A+ F VL F TGIMAG+N SG+L+D ++IP+GTI+A+ T VY
Sbjct: 377 LPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYF 436
Query: 315 LLFFLSSFTCDRTLLQEDYGFFRAISL------WPP--LVLIGIYATALSASMSSLIGAS 366
L + +L++ YG + +L WP +++IG + + A + SL GA
Sbjct: 437 SSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAP 496
Query: 367 RILHALARDDL--FGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVF 424
R+L A+A+D++ F + KV G P A+L + + +L +L L+ +A ++++F
Sbjct: 497 RLLQAIAKDNIIPFLRVFGHGKV---NGEPTWALLLTALIAELGILIASLDMVAPILSMF 553
Query: 425 YLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLL 484
+L+ Y V+L+C PN+RP F + W LG++ CL +MF+ S A ++L+
Sbjct: 554 FLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLI 613
Query: 485 MGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLL------- 537
G++ + +G WG + L R LLRL+ H K WRPQLL+L
Sbjct: 614 AGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDL 673
Query: 538 -VGNPRGALPLLRLANQLKKG-GLYVLGHVTLGD-LDSLPSDPVQPQYGAWLSLVDRAQV 594
V PR LL A+QLK G GL ++G V G L+S Q ++++ +V
Sbjct: 674 HVKYPR----LLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ--TIKNMMEIEKV 727
Query: 595 KAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDP-AFSEPADS 653
K F + ++ VR+G HL++ GLGGM+ N++VLG+ P DP A+ D+
Sbjct: 728 KGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGW----PYGWRQSEDPRAWKTFIDT 783
Query: 654 TREGSSPALSTLFPPPRAPGSPRALNPQDYVATVADALKMNKNVVLARASGALPPERLSR 713
R ++ L+ L P KN+ ++ ER
Sbjct: 784 VRCTTAAHLALLVP---------------------------KNIAFYPSN----HERYLE 812
Query: 714 GSGGTSQLHHVDVWPLNLLRPRGGPGYVDVCGLFLLQMATILGMVPAWHSARLRIFLCLG 773
G H+DVW ++ G L+ + +L W R+RIF
Sbjct: 813 G--------HIDVW------------WIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQ 852
Query: 774 PREAPGAAEGRLRALLSQLRIRAEVQEV 801
+ + L L LR+ AEV+ V
Sbjct: 853 MDDNSIQMKKDLAVFLYHLRLEAEVEVV 880
>gi|225579065 solute carrier family 12, member 4 isoform d [Homo
sapiens]
Length = 1079
Score = 264 bits (674), Expect = 3e-70
Identities = 251/868 (28%), Positives = 391/868 (45%), Gaps = 167/868 (19%)
Query: 32 ASARKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVC 91
A A + T +GV +P + ++F +++FLR+ ++VG AG+LQAL ++L+ LT +S+
Sbjct: 107 AEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMS 166
Query: 92 AIATNGAVQGGGAYFMISRTLGPEVGGSIGLMFYLAN-------VCGCAVSLLGLVESVL 144
AIATNG V GG+YFMISR+LGPE GG++GL FYL + G LL +
Sbjct: 167 AIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPA 226
Query: 145 DVF---GADATGPSGLRVLPQGYGWNLL----------------YGSLLLGLV------- 178
+F GA T + L + + YG L + SL L V
Sbjct: 227 AIFYPSGAHDTSNATLNNM-RVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSI 285
Query: 179 --GG-----------VCTLGAGLYARASF----LTFLLVSGSLASVLISFVAVGPRDIRL 221
GG VC LG +R F T ++ + ++A+ L SF P
Sbjct: 286 YAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTD 345
Query: 222 TPRPG---PNGSSLPPRFGHFTGFNSSTLKDNLGAGYAE--------------------D 258
+ P N + +P G + L++NL + Y E
Sbjct: 346 SCDPYFMLNNVTEIPG----IPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKES 401
Query: 259 YTTGAVMNFASVFAVL----FNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYV 314
V + A+ F VL F TGIMAG+N SG+L+D ++IP+GTI+A+ T VY
Sbjct: 402 LPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYF 461
Query: 315 LLFFLSSFTCDRTLLQEDYGFFRAISL------WPP--LVLIGIYATALSASMSSLIGAS 366
L + +L++ YG + +L WP +++IG + + A + SL GA
Sbjct: 462 SSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAP 521
Query: 367 RILHALARDDL--FGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVF 424
R+L A+A+D++ F + KV G P A+L + + +L +L L+ +A ++++F
Sbjct: 522 RLLQAIAKDNIIPFLRVFGHGKV---NGEPTWALLLTALIAELGILIASLDMVAPILSMF 578
Query: 425 YLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLL 484
+L+ Y V+L+C PN+RP F + W LG++ CL +MF+ S A ++L+
Sbjct: 579 FLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLI 638
Query: 485 MGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLL------- 537
G++ + +G WG + L R LLRL+ H K WRPQLL+L
Sbjct: 639 AGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDL 698
Query: 538 -VGNPRGALPLLRLANQLKKG-GLYVLGHVTLGD-LDSLPSDPVQPQYGAWLSLVDRAQV 594
V PR LL A+QLK G GL ++G V G L+S Q ++++ +V
Sbjct: 699 HVKYPR----LLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ--TIKNMMEIEKV 752
Query: 595 KAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDP-AFSEPADS 653
K F + ++ VR+G HL++ GLGGM+ N++VLG+ P DP A+ D+
Sbjct: 753 KGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGW----PYGWRQSEDPRAWKTFIDT 808
Query: 654 TREGSSPALSTLFPPPRAPGSPRALNPQDYVATVADALKMNKNVVLARASGALPPERLSR 713
R ++ L+ L P KN+ ++ ER
Sbjct: 809 VRCTTAAHLALLVP---------------------------KNIAFYPSN----HERYLE 837
Query: 714 GSGGTSQLHHVDVWPLNLLRPRGGPGYVDVCGLFLLQMATILGMVPAWHSARLRIFLCLG 773
G H+DVW ++ G L+ + +L W R+RIF
Sbjct: 838 G--------HIDVW------------WIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQ 877
Query: 774 PREAPGAAEGRLRALLSQLRIRAEVQEV 801
+ + L L LR+ AEV+ V
Sbjct: 878 MDDNSIQMKKDLAVFLYHLRLEAEVEVV 905
>gi|225579063 solute carrier family 12, member 4 isoform c [Homo
sapiens]
Length = 1087
Score = 264 bits (674), Expect = 3e-70
Identities = 251/868 (28%), Positives = 391/868 (45%), Gaps = 167/868 (19%)
Query: 32 ASARKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVC 91
A A + T +GV +P + ++F +++FLR+ ++VG AG+LQAL ++L+ LT +S+
Sbjct: 115 AEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMS 174
Query: 92 AIATNGAVQGGGAYFMISRTLGPEVGGSIGLMFYLAN-------VCGCAVSLLGLVESVL 144
AIATNG V GG+YFMISR+LGPE GG++GL FYL + G LL +
Sbjct: 175 AIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPA 234
Query: 145 DVF---GADATGPSGLRVLPQGYGWNLL----------------YGSLLLGLV------- 178
+F GA T + L + + YG L + SL L V
Sbjct: 235 AIFYPSGAHDTSNATLNNM-RVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSI 293
Query: 179 --GG-----------VCTLGAGLYARASF----LTFLLVSGSLASVLISFVAVGPRDIRL 221
GG VC LG +R F T ++ + ++A+ L SF P
Sbjct: 294 YAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTD 353
Query: 222 TPRPG---PNGSSLPPRFGHFTGFNSSTLKDNLGAGYAE--------------------D 258
+ P N + +P G + L++NL + Y E
Sbjct: 354 SCDPYFMLNNVTEIPG----IPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKES 409
Query: 259 YTTGAVMNFASVFAVL----FNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYV 314
V + A+ F VL F TGIMAG+N SG+L+D ++IP+GTI+A+ T VY
Sbjct: 410 LPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYF 469
Query: 315 LLFFLSSFTCDRTLLQEDYGFFRAISL------WPP--LVLIGIYATALSASMSSLIGAS 366
L + +L++ YG + +L WP +++IG + + A + SL GA
Sbjct: 470 SSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAP 529
Query: 367 RILHALARDDL--FGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVF 424
R+L A+A+D++ F + KV G P A+L + + +L +L L+ +A ++++F
Sbjct: 530 RLLQAIAKDNIIPFLRVFGHGKV---NGEPTWALLLTALIAELGILIASLDMVAPILSMF 586
Query: 425 YLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLL 484
+L+ Y V+L+C PN+RP F + W LG++ CL +MF+ S A ++L+
Sbjct: 587 FLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLI 646
Query: 485 MGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLL------- 537
G++ + +G WG + L R LLRL+ H K WRPQLL+L
Sbjct: 647 AGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDL 706
Query: 538 -VGNPRGALPLLRLANQLKKG-GLYVLGHVTLGD-LDSLPSDPVQPQYGAWLSLVDRAQV 594
V PR LL A+QLK G GL ++G V G L+S Q ++++ +V
Sbjct: 707 HVKYPR----LLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ--TIKNMMEIEKV 760
Query: 595 KAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDP-AFSEPADS 653
K F + ++ VR+G HL++ GLGGM+ N++VLG+ P DP A+ D+
Sbjct: 761 KGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGW----PYGWRQSEDPRAWKTFIDT 816
Query: 654 TREGSSPALSTLFPPPRAPGSPRALNPQDYVATVADALKMNKNVVLARASGALPPERLSR 713
R ++ L+ L P KN+ ++ ER
Sbjct: 817 VRCTTAAHLALLVP---------------------------KNIAFYPSN----HERYLE 845
Query: 714 GSGGTSQLHHVDVWPLNLLRPRGGPGYVDVCGLFLLQMATILGMVPAWHSARLRIFLCLG 773
G H+DVW ++ G L+ + +L W R+RIF
Sbjct: 846 G--------HIDVW------------WIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQ 885
Query: 774 PREAPGAAEGRLRALLSQLRIRAEVQEV 801
+ + L L LR+ AEV+ V
Sbjct: 886 MDDNSIQMKKDLAVFLYHLRLEAEVEVV 913
>gi|4827006 solute carrier family 12, member 4 isoform a [Homo
sapiens]
Length = 1085
Score = 264 bits (674), Expect = 3e-70
Identities = 251/868 (28%), Positives = 391/868 (45%), Gaps = 167/868 (19%)
Query: 32 ASARKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVC 91
A A + T +GV +P + ++F +++FLR+ ++VG AG+LQAL ++L+ LT +S+
Sbjct: 113 AEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMS 172
Query: 92 AIATNGAVQGGGAYFMISRTLGPEVGGSIGLMFYLAN-------VCGCAVSLLGLVESVL 144
AIATNG V GG+YFMISR+LGPE GG++GL FYL + G LL +
Sbjct: 173 AIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPA 232
Query: 145 DVF---GADATGPSGLRVLPQGYGWNLL----------------YGSLLLGLV------- 178
+F GA T + L + + YG L + SL L V
Sbjct: 233 AIFYPSGAHDTSNATLNNM-RVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSI 291
Query: 179 --GG-----------VCTLGAGLYARASF----LTFLLVSGSLASVLISFVAVGPRDIRL 221
GG VC LG +R F T ++ + ++A+ L SF P
Sbjct: 292 YAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTD 351
Query: 222 TPRPG---PNGSSLPPRFGHFTGFNSSTLKDNLGAGYAE--------------------D 258
+ P N + +P G + L++NL + Y E
Sbjct: 352 SCDPYFMLNNVTEIPG----IPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKES 407
Query: 259 YTTGAVMNFASVFAVL----FNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYV 314
V + A+ F VL F TGIMAG+N SG+L+D ++IP+GTI+A+ T VY
Sbjct: 408 LPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYF 467
Query: 315 LLFFLSSFTCDRTLLQEDYGFFRAISL------WPP--LVLIGIYATALSASMSSLIGAS 366
L + +L++ YG + +L WP +++IG + + A + SL GA
Sbjct: 468 SSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAP 527
Query: 367 RILHALARDDL--FGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVF 424
R+L A+A+D++ F + KV G P A+L + + +L +L L+ +A ++++F
Sbjct: 528 RLLQAIAKDNIIPFLRVFGHGKV---NGEPTWALLLTALIAELGILIASLDMVAPILSMF 584
Query: 425 YLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLL 484
+L+ Y V+L+C PN+RP F + W LG++ CL +MF+ S A ++L+
Sbjct: 585 FLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLI 644
Query: 485 MGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLL------- 537
G++ + +G WG + L R LLRL+ H K WRPQLL+L
Sbjct: 645 AGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDL 704
Query: 538 -VGNPRGALPLLRLANQLKKG-GLYVLGHVTLGD-LDSLPSDPVQPQYGAWLSLVDRAQV 594
V PR LL A+QLK G GL ++G V G L+S Q ++++ +V
Sbjct: 705 HVKYPR----LLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ--TIKNMMEIEKV 758
Query: 595 KAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDP-AFSEPADS 653
K F + ++ VR+G HL++ GLGGM+ N++VLG+ P DP A+ D+
Sbjct: 759 KGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGW----PYGWRQSEDPRAWKTFIDT 814
Query: 654 TREGSSPALSTLFPPPRAPGSPRALNPQDYVATVADALKMNKNVVLARASGALPPERLSR 713
R ++ L+ L P KN+ ++ ER
Sbjct: 815 VRCTTAAHLALLVP---------------------------KNIAFYPSN----HERYLE 843
Query: 714 GSGGTSQLHHVDVWPLNLLRPRGGPGYVDVCGLFLLQMATILGMVPAWHSARLRIFLCLG 773
G H+DVW ++ G L+ + +L W R+RIF
Sbjct: 844 G--------HIDVW------------WIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQ 883
Query: 774 PREAPGAAEGRLRALLSQLRIRAEVQEV 801
+ + L L LR+ AEV+ V
Sbjct: 884 MDDNSIQMKKDLAVFLYHLRLEAEVEVV 911
>gi|225579061 solute carrier family 12, member 4 isoform b [Homo
sapiens]
Length = 1079
Score = 262 bits (670), Expect = 9e-70
Identities = 217/697 (31%), Positives = 338/697 (48%), Gaps = 111/697 (15%)
Query: 32 ASARKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVC 91
A A + T +GV +P + ++F +++FLR+ ++VG AG+LQAL ++L+ LT +S+
Sbjct: 113 AEAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMS 172
Query: 92 AIATNGAVQGGGAYFMISRTLGPEVGGSIGLMFYLAN-------VCGCAVSLLGLVESVL 144
AIATNG V GG+YFMISR+LGPE GG++GL FYL + G LL +
Sbjct: 173 AIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPA 232
Query: 145 DVF---GADATGPSGLRVLPQGYGWNLL----------------YGSLLLGLV------- 178
+F GA T + L + + YG L + SL L V
Sbjct: 233 AIFYPSGAHDTSNATLNNM-RVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSI 291
Query: 179 --GG-----------VCTLGAGLYARASF----LTFLLVSGSLASVLISFVAVGPRDIRL 221
GG VC LG +R F T ++ + ++A+ L SF P
Sbjct: 292 YAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTD 351
Query: 222 TPRPG---PNGSSLPPRFGHFTGFNSSTLKDNLGAGYAE--------------------D 258
+ P N + +P G + L++NL + Y E
Sbjct: 352 SCDPYFMLNNVTEIPG----IPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKES 407
Query: 259 YTTGAVMNFASVFAVL----FNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYV 314
V + A+ F VL F TGIMAG+N SG+L+D ++IP+GTI+A+ T VY
Sbjct: 408 LPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYF 467
Query: 315 LLFFLSSFTCDRTLLQEDYGFFRAISL------WPP--LVLIGIYATALSASMSSLIGAS 366
L + +L++ YG + +L WP +++IG + + A + SL GA
Sbjct: 468 SSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAP 527
Query: 367 RILHALARDDL--FGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVF 424
R+L A+A+D++ F + KV G P A+L + + +L +L L+ +A ++++F
Sbjct: 528 RLLQAIAKDNIIPFLRVFGHGKV---NGEPTWALLLTALIAELGILIASLDMVAPILSMF 584
Query: 425 YLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLL 484
+L+ Y V+L+C PN+RP F + W LG++ CL +MF+ S A ++L+
Sbjct: 585 FLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLI 644
Query: 485 MGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLL------- 537
G++ + +G WG + L R LLRL+ H K WRPQLL+L
Sbjct: 645 AGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDL 704
Query: 538 -VGNPRGALPLLRLANQLKKG-GLYVLGHVTLGD-LDSLPSDPVQPQYGAWLSLVDRAQV 594
V PR LL A+QLK G GL ++G V G L+S Q ++++ +V
Sbjct: 705 HVKYPR----LLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQ--TIKNMMEIEKV 758
Query: 595 KAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGF 631
K F + ++ VR+G HL++ GLGGM+ N++VLG+
Sbjct: 759 KGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGW 795
>gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo
sapiens]
Length = 1021
Score = 248 bits (634), Expect = 1e-65
Identities = 173/639 (27%), Positives = 320/639 (50%), Gaps = 86/639 (13%)
Query: 42 GVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIATNGAVQG 101
GV++ +L+++ ++++LR+ ++ AG++ ++L++ + ++T LS+ AI+TNG V+
Sbjct: 141 GVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKS 200
Query: 102 GGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLDV---FGADATGP-SGL 157
GG YF+ISR+LGPE+GGSIGL+F AN G A+ +G E+V D+ +GA P + +
Sbjct: 201 GGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVDPINDI 260
Query: 158 RVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLISFVAVGPR 217
R++ G + + ++ + G ++A L FL++ S A+ L+
Sbjct: 261 RII----------GVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLV-------- 302
Query: 218 DIRLTPRPGPNGSSLPPRFGH----FTGFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAV 273
G+ +PP F + + NL + G F +F++
Sbjct: 303 -----------GTLIPPSEDKASKGFFSYRADIFVQNLVPDW-----RGPDGTFFGMFSI 346
Query: 274 LFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFL--SSFTCDRTLLQE 331
F TGI+AGAN+SG+LKDP+ AIP GT++A+ +T Y+ + S D + +
Sbjct: 347 FFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLN 406
Query: 332 D---------------YG------------------FFRAISL---WPPLVLIGIYATAL 355
D YG +++ +S+ + PL+ GI+ L
Sbjct: 407 DTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATL 466
Query: 356 SASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLN 415
S++++ L+ A+++ L D L+ +I K + P L ++ + ++ +LN
Sbjct: 467 SSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELN 526
Query: 416 TLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISP 475
T+A +++ F+L +YA ++ SC ++P +RP+F ++ L G +++MFL++
Sbjct: 527 TIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTW 586
Query: 476 GAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLL 535
AA ++ ++ L + + +WG QA ++ Y + L+ +DH+K +RPQ L
Sbjct: 587 WAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCL 646
Query: 536 LLVGNPRGALPLLRLANQLKKG-GLYVLGHVTLG-DLDSLPS-DPVQPQYGAWLSLVDRA 592
+L G P L+ + L + GHV +G +P + + WL ++
Sbjct: 647 VLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWL---NKR 703
Query: 593 QVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGF 631
++KAF ++ +R+G Q L++ +GLG MKPN LV+GF
Sbjct: 704 KIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGF 742
>gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo
sapiens]
Length = 1029
Score = 248 bits (634), Expect = 1e-65
Identities = 173/639 (27%), Positives = 320/639 (50%), Gaps = 86/639 (13%)
Query: 42 GVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIATNGAVQG 101
GV++ +L+++ ++++LR+ ++ AG++ ++L++ + ++T LS+ AI+TNG V+
Sbjct: 140 GVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKS 199
Query: 102 GGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLDV---FGADATGP-SGL 157
GG YF+ISR+LGPE+GGSIGL+F AN G A+ +G E+V D+ +GA P + +
Sbjct: 200 GGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVDPINDI 259
Query: 158 RVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLISFVAVGPR 217
R++ G + + ++ + G ++A L FL++ S A+ L+
Sbjct: 260 RII----------GVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLV-------- 301
Query: 218 DIRLTPRPGPNGSSLPPRFGH----FTGFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAV 273
G+ +PP F + + NL + G F +F++
Sbjct: 302 -----------GTLIPPSEDKASKGFFSYRADIFVQNLVPDW-----RGPDGTFFGMFSI 345
Query: 274 LFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFL--SSFTCDRTLLQE 331
F TGI+AGAN+SG+LKDP+ AIP GT++A+ +T Y+ + S D + +
Sbjct: 346 FFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLN 405
Query: 332 D---------------YG------------------FFRAISL---WPPLVLIGIYATAL 355
D YG +++ +S+ + PL+ GI+ L
Sbjct: 406 DTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATL 465
Query: 356 SASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLN 415
S++++ L+ A+++ L D L+ +I K + P L ++ + ++ +LN
Sbjct: 466 SSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELN 525
Query: 416 TLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISP 475
T+A +++ F+L +YA ++ SC ++P +RP+F ++ L G +++MFL++
Sbjct: 526 TIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTW 585
Query: 476 GAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLL 535
AA ++ ++ L + + +WG QA ++ Y + L+ +DH+K +RPQ L
Sbjct: 586 WAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCL 645
Query: 536 LLVGNPRGALPLLRLANQLKKG-GLYVLGHVTLG-DLDSLPS-DPVQPQYGAWLSLVDRA 592
+L G P L+ + L + GHV +G +P + + WL ++
Sbjct: 646 VLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWL---NKR 702
Query: 593 QVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGF 631
++KAF ++ +R+G Q L++ +GLG MKPN LV+GF
Sbjct: 703 KIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGF 741
>gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo
sapiens]
Length = 1030
Score = 248 bits (634), Expect = 1e-65
Identities = 173/639 (27%), Positives = 320/639 (50%), Gaps = 86/639 (13%)
Query: 42 GVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIATNGAVQG 101
GV++ +L+++ ++++LR+ ++ AG++ ++L++ + ++T LS+ AI+TNG V+
Sbjct: 141 GVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKS 200
Query: 102 GGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLDV---FGADATGP-SGL 157
GG YF+ISR+LGPE+GGSIGL+F AN G A+ +G E+V D+ +GA P + +
Sbjct: 201 GGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVDPINDI 260
Query: 158 RVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLISFVAVGPR 217
R++ G + + ++ + G ++A L FL++ S A+ L+
Sbjct: 261 RII----------GVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANYLV-------- 302
Query: 218 DIRLTPRPGPNGSSLPPRFGH----FTGFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAV 273
G+ +PP F + + NL + G F +F++
Sbjct: 303 -----------GTLIPPSEDKASKGFFSYRADIFVQNLVPDW-----RGPDGTFFGMFSI 346
Query: 274 LFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFL--SSFTCDRTLLQE 331
F TGI+AGAN+SG+LKDP+ AIP GT++A+ +T Y+ + S D + +
Sbjct: 347 FFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLN 406
Query: 332 D---------------YG------------------FFRAISL---WPPLVLIGIYATAL 355
D YG +++ +S+ + PL+ GI+ L
Sbjct: 407 DTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATL 466
Query: 356 SASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLN 415
S++++ L+ A+++ L D L+ +I K + P L ++ + ++ +LN
Sbjct: 467 SSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELN 526
Query: 416 TLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISP 475
T+A +++ F+L +YA ++ SC ++P +RP+F ++ L G +++MFL++
Sbjct: 527 TIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTW 586
Query: 476 GAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLL 535
AA ++ ++ L + + +WG QA ++ Y + L+ +DH+K +RPQ L
Sbjct: 587 WAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCL 646
Query: 536 LLVGNPRGALPLLRLANQLKKG-GLYVLGHVTLG-DLDSLPS-DPVQPQYGAWLSLVDRA 592
+L G P L+ + L + GHV +G +P + + WL ++
Sbjct: 647 VLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWL---NKR 703
Query: 593 QVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGF 631
++KAF ++ +R+G Q L++ +GLG MKPN LV+GF
Sbjct: 704 KIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGF 742
>gi|123701900 solute carrier family 12 (potassium/chloride
transporters), member 7 [Homo sapiens]
Length = 1083
Score = 197 bits (501), Expect = 4e-50
Identities = 151/558 (27%), Positives = 256/558 (45%), Gaps = 77/558 (13%)
Query: 261 TGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLS 320
T +F + + F TGIMAG+N SG+LKD ++IP GTI+A+ T F+Y+ L
Sbjct: 414 TDIAASFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLF 473
Query: 321 SFTCDRTLLQEDYG------FFRAISLWPP--LVLIGIYATALSASMSSLIGASRILHAL 372
+ +L++ +G + WP +++IG + + A + SL GA R+L A+
Sbjct: 474 GACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAI 533
Query: 373 ARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAV 432
ARD + + + G WA +L + + +L L+++A ++++F+L+ Y V
Sbjct: 534 ARDGIVPFLQVFGHGKANGEPTWALLLTVL-ICETGILIASLDSVAPILSMFFLMCYLFV 592
Query: 433 DLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAALL 492
+L+C PN+RP F + W LG++ CL +MF+ S A ++L+ G + +
Sbjct: 593 NLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYI 652
Query: 493 TARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLL--------VGNPRGA 544
RG WG + L + R LLR++ H K WRPQ+L++ V +PR
Sbjct: 653 EYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDAEQAVKHPR-- 710
Query: 545 LPLLRLANQLKKG-GLYVLGHVTLGDLDSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLS 603
LL +QLK G GL ++G V G + + + SL+ + K F L +S
Sbjct: 711 --LLSFTSQLKAGKGLTIVGSVLEGTYLDKHMEAQRAEENI-RSLMSTEKTKGFCQLVVS 767
Query: 604 PSVRQGAQHLLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDPAFSEPADSTREGSSPALS 663
S+R G HL++ +GLGG+K NT+++ + PA +E +
Sbjct: 768 SSLRDGMSHLIQSAGLGGLKHNTVLMAW------------------PASWKQEDN----- 804
Query: 664 TLFPPPRAPGSPRALNPQDYVATVADALKMNKNVVLARASGALPPERLSRGSGGTSQLHH 723
+ +++V TV D ++ +++A+ + P + G G H
Sbjct: 805 -------------PFSWKNFVDTVRDTTAAHQALLVAKNVDSFPQNQERFGGG------H 845
Query: 724 VDVWPLNLLRPRGGPGYVDVCGLFLLQMATILGMVPAWHSARLRIFLCLGPREAPGAAEG 783
+DVW ++ G L+ + +L W R+RIF + +
Sbjct: 846 IDVW------------WIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKK 893
Query: 784 RLRALLSQLRIRAEVQEV 801
L+ L LRI AEV+ V
Sbjct: 894 DLQMFLYHLRISAEVEVV 911
Score = 108 bits (269), Expect = 3e-23
Identities = 67/190 (35%), Positives = 107/190 (56%), Gaps = 18/190 (9%)
Query: 32 ASARKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVC 91
A A ++ TF+GV +P + ++ +++FLR+ ++VG AG+L++ ++ + LT +S+
Sbjct: 113 AKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMS 172
Query: 92 AIATNGAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLD------ 145
AIATNG V GG+Y+MISR+LGPE GG++GL FYL A+ +LG +E L
Sbjct: 173 AIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGA 232
Query: 146 -VFGADATGPSGLRVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSL 204
+F A+A G +L +YG+ L L+ V +G Y L F L
Sbjct: 233 AIFQAEAAGGEAAAMLHN----MRVYGTCTLVLMALVVFVGV-KYVNKLALVF------L 281
Query: 205 ASVLISFVAV 214
A V++S +A+
Sbjct: 282 ACVVLSILAI 291
>gi|110224458 solute carrier family 12, member 6 isoform e [Homo
sapiens]
Length = 1135
Score = 195 bits (496), Expect = 1e-49
Identities = 130/412 (31%), Positives = 214/412 (51%), Gaps = 37/412 (8%)
Query: 244 SSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTI 303
S+ D LG+ E +F + + F TGIMAG+N SG+LKD ++IP+GTI
Sbjct: 447 SAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTI 506
Query: 304 VAVAYTFFVYVLLFFLSSFTCDRTLLQEDYGFFRAISL------WPP--LVLIGIYATAL 355
+A+ T FVY+ L + +L++ +G +L WP +++IG + +
Sbjct: 507 LAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTC 566
Query: 356 SASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLN 415
A + SL GA R+L A+A+D++ + + G WA +L + + +L +L L+
Sbjct: 567 GAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTA-AIAELGILIASLD 625
Query: 416 TLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISP 475
+A ++++F+L+ Y V+L+C PN+RP F + W +G++ CL +MF+ S
Sbjct: 626 LVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSW 685
Query: 476 GAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLL 535
A ++++ G++ + +G WG + L R LLRL+ H K WRPQLL
Sbjct: 686 YYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLL 745
Query: 536 LL--------VGNPRGALPLLRLANQLKKG-GLYVLGHVTLGDLDSLPSDPVQPQYGAWL 586
+L V +PR LL A+QLK G GL ++G V +G+ YG L
Sbjct: 746 VLLKLDEDLHVKHPR----LLTFASQLKAGKGLTIVGSVIVGNF--------LENYGEAL 793
Query: 587 S-------LVDRAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGF 631
+ L++ +VK F L ++ +R+G HL++ GLGGMK NT+V+G+
Sbjct: 794 AAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGW 845
Score = 112 bits (279), Expect = 2e-24
Identities = 53/109 (48%), Positives = 77/109 (70%)
Query: 36 KLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIAT 95
++ TF+GV +P + ++F +++FLR+ +VVG AG+LQA A++L+ LT +S+ AIAT
Sbjct: 169 QMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIAT 228
Query: 96 NGAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVL 144
NG V GG+YFMISR LGPE GG++GL FYL A+ +LG +E L
Sbjct: 229 NGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFL 277
Score = 31.6 bits (70), Expect = 3.5
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 868 LTFLYLPRPPADPARYPRYLALLETLTRDLGPTLLVHG 905
L L +P PP +P Y+ LE LT L LLV G
Sbjct: 1088 LVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRG 1125
>gi|110224456 solute carrier family 12, member 6 isoform d [Homo
sapiens]
Length = 1141
Score = 195 bits (496), Expect = 1e-49
Identities = 130/412 (31%), Positives = 214/412 (51%), Gaps = 37/412 (8%)
Query: 244 SSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTI 303
S+ D LG+ E +F + + F TGIMAG+N SG+LKD ++IP+GTI
Sbjct: 453 SAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTI 512
Query: 304 VAVAYTFFVYVLLFFLSSFTCDRTLLQEDYGFFRAISL------WPP--LVLIGIYATAL 355
+A+ T FVY+ L + +L++ +G +L WP +++IG + +
Sbjct: 513 LAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTC 572
Query: 356 SASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLN 415
A + SL GA R+L A+A+D++ + + G WA +L + + +L +L L+
Sbjct: 573 GAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTA-AIAELGILIASLD 631
Query: 416 TLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISP 475
+A ++++F+L+ Y V+L+C PN+RP F + W +G++ CL +MF+ S
Sbjct: 632 LVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSW 691
Query: 476 GAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLL 535
A ++++ G++ + +G WG + L R LLRL+ H K WRPQLL
Sbjct: 692 YYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLL 751
Query: 536 LL--------VGNPRGALPLLRLANQLKKG-GLYVLGHVTLGDLDSLPSDPVQPQYGAWL 586
+L V +PR LL A+QLK G GL ++G V +G+ YG L
Sbjct: 752 VLLKLDEDLHVKHPR----LLTFASQLKAGKGLTIVGSVIVGNF--------LENYGEAL 799
Query: 587 S-------LVDRAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGF 631
+ L++ +VK F L ++ +R+G HL++ GLGGMK NT+V+G+
Sbjct: 800 AAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGW 851
Score = 112 bits (279), Expect = 2e-24
Identities = 53/109 (48%), Positives = 77/109 (70%)
Query: 36 KLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIAT 95
++ TF+GV +P + ++F +++FLR+ +VVG AG+LQA A++L+ LT +S+ AIAT
Sbjct: 175 QMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIAT 234
Query: 96 NGAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVL 144
NG V GG+YFMISR LGPE GG++GL FYL A+ +LG +E L
Sbjct: 235 NGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFL 283
Score = 31.6 bits (70), Expect = 3.5
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 868 LTFLYLPRPPADPARYPRYLALLETLTRDLGPTLLVHG 905
L L +P PP +P Y+ LE LT L LLV G
Sbjct: 1094 LVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRG 1131
>gi|110224454 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 195 bits (496), Expect = 1e-49
Identities = 130/412 (31%), Positives = 214/412 (51%), Gaps = 37/412 (8%)
Query: 244 SSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTI 303
S+ D LG+ E +F + + F TGIMAG+N SG+LKD ++IP+GTI
Sbjct: 403 SAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTI 462
Query: 304 VAVAYTFFVYVLLFFLSSFTCDRTLLQEDYGFFRAISL------WPP--LVLIGIYATAL 355
+A+ T FVY+ L + +L++ +G +L WP +++IG + +
Sbjct: 463 LAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTC 522
Query: 356 SASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLN 415
A + SL GA R+L A+A+D++ + + G WA +L + + +L +L L+
Sbjct: 523 GAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTA-AIAELGILIASLD 581
Query: 416 TLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISP 475
+A ++++F+L+ Y V+L+C PN+RP F + W +G++ CL +MF+ S
Sbjct: 582 LVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSW 641
Query: 476 GAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLL 535
A ++++ G++ + +G WG + L R LLRL+ H K WRPQLL
Sbjct: 642 YYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLL 701
Query: 536 LL--------VGNPRGALPLLRLANQLKKG-GLYVLGHVTLGDLDSLPSDPVQPQYGAWL 586
+L V +PR LL A+QLK G GL ++G V +G+ YG L
Sbjct: 702 VLLKLDEDLHVKHPR----LLTFASQLKAGKGLTIVGSVIVGNF--------LENYGEAL 749
Query: 587 S-------LVDRAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGF 631
+ L++ +VK F L ++ +R+G HL++ GLGGMK NT+V+G+
Sbjct: 750 AAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGW 801
Score = 112 bits (279), Expect = 2e-24
Identities = 53/109 (48%), Positives = 77/109 (70%)
Query: 36 KLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIAT 95
++ TF+GV +P + ++F +++FLR+ +VVG AG+LQA A++L+ LT +S+ AIAT
Sbjct: 125 QMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIAT 184
Query: 96 NGAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVL 144
NG V GG+YFMISR LGPE GG++GL FYL A+ +LG +E L
Sbjct: 185 NGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFL 233
Score = 31.6 bits (70), Expect = 3.5
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 868 LTFLYLPRPPADPARYPRYLALLETLTRDLGPTLLVHG 905
L L +P PP +P Y+ LE LT L LLV G
Sbjct: 1044 LVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRG 1081
>gi|110224452 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 195 bits (496), Expect = 1e-49
Identities = 130/412 (31%), Positives = 214/412 (51%), Gaps = 37/412 (8%)
Query: 244 SSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTI 303
S+ D LG+ E +F + + F TGIMAG+N SG+LKD ++IP+GTI
Sbjct: 403 SAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTI 462
Query: 304 VAVAYTFFVYVLLFFLSSFTCDRTLLQEDYGFFRAISL------WPP--LVLIGIYATAL 355
+A+ T FVY+ L + +L++ +G +L WP +++IG + +
Sbjct: 463 LAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTC 522
Query: 356 SASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLN 415
A + SL GA R+L A+A+D++ + + G WA +L + + +L +L L+
Sbjct: 523 GAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTA-AIAELGILIASLD 581
Query: 416 TLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISP 475
+A ++++F+L+ Y V+L+C PN+RP F + W +G++ CL +MF+ S
Sbjct: 582 LVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSW 641
Query: 476 GAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLL 535
A ++++ G++ + +G WG + L R LLRL+ H K WRPQLL
Sbjct: 642 YYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLL 701
Query: 536 LL--------VGNPRGALPLLRLANQLKKG-GLYVLGHVTLGDLDSLPSDPVQPQYGAWL 586
+L V +PR LL A+QLK G GL ++G V +G+ YG L
Sbjct: 702 VLLKLDEDLHVKHPR----LLTFASQLKAGKGLTIVGSVIVGNF--------LENYGEAL 749
Query: 587 S-------LVDRAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGF 631
+ L++ +VK F L ++ +R+G HL++ GLGGMK NT+V+G+
Sbjct: 750 AAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGW 801
Score = 112 bits (279), Expect = 2e-24
Identities = 53/109 (48%), Positives = 77/109 (70%)
Query: 36 KLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIAT 95
++ TF+GV +P + ++F +++FLR+ +VVG AG+LQA A++L+ LT +S+ AIAT
Sbjct: 125 QMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIAT 184
Query: 96 NGAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVL 144
NG V GG+YFMISR LGPE GG++GL FYL A+ +LG +E L
Sbjct: 185 NGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFL 233
Score = 31.6 bits (70), Expect = 3.5
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 868 LTFLYLPRPPADPARYPRYLALLETLTRDLGPTLLVHG 905
L L +P PP +P Y+ LE LT L LLV G
Sbjct: 1044 LVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRG 1081
>gi|4826780 solute carrier family 12, member 6 isoform b [Homo
sapiens]
Length = 1099
Score = 195 bits (496), Expect = 1e-49
Identities = 130/412 (31%), Positives = 214/412 (51%), Gaps = 37/412 (8%)
Query: 244 SSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTI 303
S+ D LG+ E +F + + F TGIMAG+N SG+LKD ++IP+GTI
Sbjct: 411 SAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTI 470
Query: 304 VAVAYTFFVYVLLFFLSSFTCDRTLLQEDYGFFRAISL------WPP--LVLIGIYATAL 355
+A+ T FVY+ L + +L++ +G +L WP +++IG + +
Sbjct: 471 LAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTC 530
Query: 356 SASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLN 415
A + SL GA R+L A+A+D++ + + G WA +L + + +L +L L+
Sbjct: 531 GAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTA-AIAELGILIASLD 589
Query: 416 TLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISP 475
+A ++++F+L+ Y V+L+C PN+RP F + W +G++ CL +MF+ S
Sbjct: 590 LVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSW 649
Query: 476 GAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLL 535
A ++++ G++ + +G WG + L R LLRL+ H K WRPQLL
Sbjct: 650 YYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLL 709
Query: 536 LL--------VGNPRGALPLLRLANQLKKG-GLYVLGHVTLGDLDSLPSDPVQPQYGAWL 586
+L V +PR LL A+QLK G GL ++G V +G+ YG L
Sbjct: 710 VLLKLDEDLHVKHPR----LLTFASQLKAGKGLTIVGSVIVGNF--------LENYGEAL 757
Query: 587 S-------LVDRAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGF 631
+ L++ +VK F L ++ +R+G HL++ GLGGMK NT+V+G+
Sbjct: 758 AAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGW 809
Score = 112 bits (279), Expect = 2e-24
Identities = 53/109 (48%), Positives = 77/109 (70%)
Query: 36 KLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIAT 95
++ TF+GV +P + ++F +++FLR+ +VVG AG+LQA A++L+ LT +S+ AIAT
Sbjct: 133 QMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIAT 192
Query: 96 NGAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVL 144
NG V GG+YFMISR LGPE GG++GL FYL A+ +LG +E L
Sbjct: 193 NGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFL 241
Score = 31.6 bits (70), Expect = 3.5
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 868 LTFLYLPRPPADPARYPRYLALLETLTRDLGPTLLVHG 905
L L +P PP +P Y+ LE LT L LLV G
Sbjct: 1052 LVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRG 1089
>gi|110224449 solute carrier family 12, member 6 isoform a [Homo
sapiens]
Length = 1150
Score = 195 bits (496), Expect = 1e-49
Identities = 130/412 (31%), Positives = 214/412 (51%), Gaps = 37/412 (8%)
Query: 244 SSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTI 303
S+ D LG+ E +F + + F TGIMAG+N SG+LKD ++IP+GTI
Sbjct: 462 SAKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTI 521
Query: 304 VAVAYTFFVYVLLFFLSSFTCDRTLLQEDYGFFRAISL------WPP--LVLIGIYATAL 355
+A+ T FVY+ L + +L++ +G +L WP +++IG + +
Sbjct: 522 LAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTC 581
Query: 356 SASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLN 415
A + SL GA R+L A+A+D++ + + G WA +L + + +L +L L+
Sbjct: 582 GAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTA-AIAELGILIASLD 640
Query: 416 TLAAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISP 475
+A ++++F+L+ Y V+L+C PN+RP F + W +G++ CL +MF+ S
Sbjct: 641 LVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSW 700
Query: 476 GAAGGSLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLL 535
A ++++ G++ + +G WG + L R LLRL+ H K WRPQLL
Sbjct: 701 YYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLL 760
Query: 536 LL--------VGNPRGALPLLRLANQLKKG-GLYVLGHVTLGDLDSLPSDPVQPQYGAWL 586
+L V +PR LL A+QLK G GL ++G V +G+ YG L
Sbjct: 761 VLLKLDEDLHVKHPR----LLTFASQLKAGKGLTIVGSVIVGNF--------LENYGEAL 808
Query: 587 S-------LVDRAQVKAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGF 631
+ L++ +VK F L ++ +R+G HL++ GLGGMK NT+V+G+
Sbjct: 809 AAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGW 860
Score = 112 bits (279), Expect = 2e-24
Identities = 53/109 (48%), Positives = 77/109 (70%)
Query: 36 KLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIAT 95
++ TF+GV +P + ++F +++FLR+ +VVG AG+LQA A++L+ LT +S+ AIAT
Sbjct: 184 QMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIAT 243
Query: 96 NGAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVL 144
NG V GG+YFMISR LGPE GG++GL FYL A+ +LG +E L
Sbjct: 244 NGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFL 292
Score = 31.6 bits (70), Expect = 3.5
Identities = 16/38 (42%), Positives = 19/38 (50%)
Query: 868 LTFLYLPRPPADPARYPRYLALLETLTRDLGPTLLVHG 905
L L +P PP +P Y+ LE LT L LLV G
Sbjct: 1103 LVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRG 1140
>gi|198041678 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 1 [Homo sapiens]
Length = 1139
Score = 193 bits (490), Expect = 7e-49
Identities = 157/551 (28%), Positives = 255/551 (46%), Gaps = 75/551 (13%)
Query: 267 FASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDR 326
F + + F TGIMAG+N SG+L+D ++IP GTI+A+A T VY+ L +
Sbjct: 423 FTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEG 482
Query: 327 TLLQEDYGFFRAIS--------LWPP--LVLIGIYATALSASMSSLIGASRILHALARDD 376
+L++ +G A++ WP +++IG + + A + SL GA R+L A++RD
Sbjct: 483 VVLRDKFG--EAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDG 540
Query: 377 LFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSC 436
+ + + G WA +L + + ++ +L L+ +A ++++F+L+ Y V+L+C
Sbjct: 541 IVPFLQVFGHGKANGEPTWALLLTAC-ICEIGILIASLDEVAPILSMFFLMCYMFVNLAC 599
Query: 437 LSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAALLTARG 496
PN+RP F + W LG++ CL +MF+ S A ++L+ GL+ + RG
Sbjct: 600 AVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRG 659
Query: 497 GPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGA----LPLLRLAN 552
WG + L R LLRL+ H K WRPQLL+LV + LL L +
Sbjct: 660 AEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTS 719
Query: 553 QLKKG-GLYVLGHVTLGD-LDSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGA 610
QLK G GL ++G V G L++ P Q + L++ +VK F + +S ++R G
Sbjct: 720 QLKAGKGLTIVGSVLEGTFLENHPQ--AQRAEESIRRLMEAEKVKGFCQVVISSNLRDGV 777
Query: 611 QHLLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDPAFSEPADSTREGSSPALSTLFPPPR 670
HL++ GLGG++ NT+++G+ + ++ T F E T G
Sbjct: 778 SHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHL----------- 826
Query: 671 APGSPRALNPQDYVATVADALKMNKNVVLARASGALPPERLSRGSGGTSQLHHVDVWPLN 730
AL + KNV + + PER S GS +DVW
Sbjct: 827 -------------------ALLVTKNVSMFPGN----PERFSEGS--------IDVW--- 852
Query: 731 LLRPRGGPGYVDVCGLFLLQMATILGMVPAWHSARLRIFLCLGPREAPGAAEGRLRALLS 790
++ G L+ + +L W ++RIF + + L L
Sbjct: 853 ---------WIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLY 903
Query: 791 QLRIRAEVQEV 801
LRI AEV+ V
Sbjct: 904 HLRITAEVEVV 914
Score = 108 bits (270), Expect = 2e-23
Identities = 51/121 (42%), Positives = 80/121 (66%)
Query: 24 NGAGGPGGASARKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFIL 83
N G A ++ TF+GV +P + ++F +++FLR+ +VVG AG++++ M+ +
Sbjct: 107 NEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCT 166
Query: 84 ALTVLSVCAIATNGAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESV 143
LT +S+ AIATNG V GG+Y+MISR+LGPE GG++GL FYL A+ +LG +E +
Sbjct: 167 MLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIL 226
Query: 144 L 144
L
Sbjct: 227 L 227
>gi|11968148 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 2 [Homo sapiens]
Length = 1116
Score = 193 bits (490), Expect = 7e-49
Identities = 157/551 (28%), Positives = 255/551 (46%), Gaps = 75/551 (13%)
Query: 267 FASVFAVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDR 326
F + + F TGIMAG+N SG+L+D ++IP GTI+A+A T VY+ L +
Sbjct: 400 FTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEG 459
Query: 327 TLLQEDYGFFRAIS--------LWPP--LVLIGIYATALSASMSSLIGASRILHALARDD 376
+L++ +G A++ WP +++IG + + A + SL GA R+L A++RD
Sbjct: 460 VVLRDKFG--EAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDG 517
Query: 377 LFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSC 436
+ + + G WA +L + + ++ +L L+ +A ++++F+L+ Y V+L+C
Sbjct: 518 IVPFLQVFGHGKANGEPTWALLLTAC-ICEIGILIASLDEVAPILSMFFLMCYMFVNLAC 576
Query: 437 LSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGAAGGSLLLMGLLAALLTARG 496
PN+RP F + W LG++ CL +MF+ S A ++L+ GL+ + RG
Sbjct: 577 AVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRG 636
Query: 497 GPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLLVGNPRGA----LPLLRLAN 552
WG + L R LLRL+ H K WRPQLL+LV + LL L +
Sbjct: 637 AEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTS 696
Query: 553 QLKKG-GLYVLGHVTLGD-LDSLPSDPVQPQYGAWLSLVDRAQVKAFVDLTLSPSVRQGA 610
QLK G GL ++G V G L++ P Q + L++ +VK F + +S ++R G
Sbjct: 697 QLKAGKGLTIVGSVLEGTFLENHPQ--AQRAEESIRRLMEAEKVKGFCQVVISSNLRDGV 754
Query: 611 QHLLRISGLGGMKPNTLVLGFYDDAPPQDHFLTDPAFSEPADSTREGSSPALSTLFPPPR 670
HL++ GLGG++ NT+++G+ + ++ T F E T G
Sbjct: 755 SHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHL----------- 803
Query: 671 APGSPRALNPQDYVATVADALKMNKNVVLARASGALPPERLSRGSGGTSQLHHVDVWPLN 730
AL + KNV + + PER S GS +DVW
Sbjct: 804 -------------------ALLVTKNVSMFPGN----PERFSEGS--------IDVW--- 829
Query: 731 LLRPRGGPGYVDVCGLFLLQMATILGMVPAWHSARLRIFLCLGPREAPGAAEGRLRALLS 790
++ G L+ + +L W ++RIF + + L L
Sbjct: 830 ---------WIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLY 880
Query: 791 QLRIRAEVQEV 801
LRI AEV+ V
Sbjct: 881 HLRITAEVEVV 891
Score = 108 bits (270), Expect = 2e-23
Identities = 51/121 (42%), Positives = 80/121 (66%)
Query: 24 NGAGGPGGASARKLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFIL 83
N G A ++ TF+GV +P + ++F +++FLR+ +VVG AG++++ M+ +
Sbjct: 84 NEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCT 143
Query: 84 ALTVLSVCAIATNGAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESV 143
LT +S+ AIATNG V GG+Y+MISR+LGPE GG++GL FYL A+ +LG +E +
Sbjct: 144 MLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIL 203
Query: 144 L 144
L
Sbjct: 204 L 204
>gi|38569457 solute carrier family 12, member 8 [Homo sapiens]
Length = 714
Score = 185 bits (470), Expect = 1e-46
Identities = 129/409 (31%), Positives = 209/409 (51%), Gaps = 44/409 (10%)
Query: 39 TFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILA--LTVLSVCAIATN 96
T+ GV ++++F +V+FLR G++VG+ G+L L M LV++ IL +TVLS +
Sbjct: 41 TWDGVFTSCMINIFGVVLFLRTGWLVGNTGVL--LGMFLVSFVILVALVTVLSGIGVGER 98
Query: 97 GAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLDVFG-ADATGPS 155
++ GG Y MIS LG + GG+IGL++ A+ + G ES+ D+ G +
Sbjct: 99 SSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLGLGNIWAVR 158
Query: 156 GLRVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLT-FLLVSGSLASVLISFVAV 214
G+ V ++LL L+G + G R L FLL +L V+ SF
Sbjct: 159 GISV------------AVLLALLG-INLAGVKWIIRLQLLLLFLLAVSTLDFVVGSF--- 202
Query: 215 GPRDIRLTPRPGPNGSSLPPRFGHFTGFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAVL 274
+ L P G F G++ L++N DY+ G +F +VF V
Sbjct: 203 ---------------THLDPEHG-FIGYSPELLQNNT----LPDYSPGE--SFFTVFGVF 240
Query: 275 FNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTLLQEDYG 334
F TG+MAG NM G+L++P+ +IPLG++ AV ++F+Y++ FL C R L+ D+
Sbjct: 241 FPAATGVMAGFNMGGDLREPAASIPLGSLAAVGISWFLYIVFVFLLGAICTREALRYDFL 300
Query: 335 FFRAISLWPPLVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNP 394
+SL L L+G+Y ++L++ M L GA RIL +A++ + + + P
Sbjct: 301 IAEKVSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTP 360
Query: 395 WAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEWAS 443
AA+ + + + G++N LA +VT+ +++ Y AVD S SL S
Sbjct: 361 VAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSMCS 409
>gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo
sapiens]
Length = 697
Score = 48.5 bits (114), Expect = 3e-05
Identities = 49/176 (27%), Positives = 78/176 (44%), Gaps = 10/176 (5%)
Query: 272 AVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTLLQE 331
A F G A E+++P +AIP+G + ++ F Y + + LL E
Sbjct: 302 ATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDE 361
Query: 332 DYGFFRAISL--WPPLVLIGIYATALSASMSSLIGAS----RILHALARDDLFGVILAPA 385
A W P + + A +L A +SL+G+ RIL A+ARD L LA
Sbjct: 362 KSPLPVAFEYVGWGPAKYV-VAAGSLCALSTSLLGSMFPLPRILFAMARDGLLFRFLAR- 419
Query: 386 KVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEW 441
VS+ +P AA L + + L+ L L ++++ L+AY+ V L L +
Sbjct: 420 --VSKRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRY 473
>gi|114326550 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 3 [Homo sapiens]
Length = 619
Score = 48.1 bits (113), Expect = 4e-05
Identities = 40/175 (22%), Positives = 75/175 (42%), Gaps = 7/175 (4%)
Query: 272 AVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTLLQE 331
A F G A E ++P R+IP+G +++++ F Y + + LQ
Sbjct: 258 ATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQP 317
Query: 332 DYGFFRAISL--WPP---LVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAK 386
+ A W P +V +G ++ + S+ R+++A+A D L +LA
Sbjct: 318 ESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIH 377
Query: 387 VVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEW 441
+R P A + S + + KL L ++++ L+AY+ V + L L +
Sbjct: 378 TGTR--TPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRY 430
>gi|114326544 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 3 [Homo sapiens]
Length = 619
Score = 48.1 bits (113), Expect = 4e-05
Identities = 40/175 (22%), Positives = 75/175 (42%), Gaps = 7/175 (4%)
Query: 272 AVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTLLQE 331
A F G A E ++P R+IP+G +++++ F Y + + LQ
Sbjct: 258 ATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQP 317
Query: 332 DYGFFRAISL--WPP---LVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAK 386
+ A W P +V +G ++ + S+ R+++A+A D L +LA
Sbjct: 318 ESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIH 377
Query: 387 VVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEW 441
+R P A + S + + KL L ++++ L+AY+ V + L L +
Sbjct: 378 TGTR--TPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRY 430
>gi|4507047 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 1 [Homo sapiens]
Length = 629
Score = 47.0 bits (110), Expect = 8e-05
Identities = 63/285 (22%), Positives = 116/285 (40%), Gaps = 30/285 (10%)
Query: 169 LYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLIS-FVAVGPRDIRLTPRPGP 227
++ +++ ++ G+ TLG A + + + L +++S FV ++ +LT
Sbjct: 166 IFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEED-- 223
Query: 228 NGSSLPPRFGHFTG---FNSSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAG 284
FG+ +G N+ T + G G + V++ A A F G
Sbjct: 224 --------FGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGA---ATCFYAFVGFDCI 272
Query: 285 ANMSGELKDPSRAIPLGTIVAVAYTFFVY-----VLLFFLSSFTCDRTLLQEDYGFFRAI 339
A E+K+P +AIP+G + ++ F Y L + F D D F+ +
Sbjct: 273 ATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNNSPLPD--AFKHV 330
Query: 340 SLWPP---LVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWA 396
W V +G ++ + S+ R+++A+A D L L A V R P
Sbjct: 331 G-WEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFL--ANVNDRTKTPII 387
Query: 397 AVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEW 441
A L S + ++ L L ++++ L+AY+ V L L +
Sbjct: 388 ATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRY 432
>gi|110347453 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 4 [Homo sapiens]
Length = 635
Score = 40.8 bits (94), Expect = 0.006
Identities = 77/311 (24%), Positives = 120/311 (38%), Gaps = 57/311 (18%)
Query: 277 GCTGIMAG--------------ANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSF 322
G +G+MAG A S E ++P R++PL +++A Y+L+ + +
Sbjct: 233 GFSGVMAGTASCFYAFVGFDVIAASSEEAQNPRRSVPLAIAISLAIAAGAYILVSTVLTL 292
Query: 323 TCDRTLLQEDY----GFFRAISLWPP-LVLIGIYATALSASMSSLIGASRILHALARDDL 377
L D F++ W +V G + +S L RI++A+A D L
Sbjct: 293 MVPWHSLDPDSALADAFYQRGYRWAGFIVAAGSICAMNTVLLSLLFSLPRIVYAMAADGL 352
Query: 378 FGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCL 437
F + A V R P A L L + L L +L +++ L+AY V S +
Sbjct: 353 FFQVF--AHVHPRTQVPVAGTLAFGLLTAFLALLLDLESLVQFLSLGTLLAYTFVATSII 410
Query: 438 SLEW-ASAPNFRP----------TFSLFSWHTCLLGVASCLL-------------MMFL- 472
L + S+P P S FS H L+G + + FL
Sbjct: 411 VLRFQKSSPPSSPGPASPGPLTKQQSSFSDHLQLVGTVHASVPEPGELKPALRPYLGFLD 470
Query: 473 -ISPGA----AGGSLLLMGLLAALLTARGGPS----SWGYVSQALLFHQVRKYLLRLDVR 523
SPGA A G +L + + G + WGY+ LL + +LL L V
Sbjct: 471 GYSPGAVVTWALGVMLASAITIGCVLVFGNSTLHLPHWGYILLLLLTSVM--FLLSLLVL 528
Query: 524 KDHVKFWRPQL 534
H + +R L
Sbjct: 529 GAHQQQYREDL 539
>gi|14110420 heterogeneous nuclear ribonucleoprotein D isoform a
[Homo sapiens]
Length = 355
Score = 37.7 bits (86), Expect = 0.049
Identities = 25/66 (37%), Positives = 30/66 (45%), Gaps = 8/66 (12%)
Query: 799 QEVVWGEGAGAGEPEAEEEGDFVNSGRGDAEAEALARSANALVRAQQGRGTGGGP--GGP 856
+E G+GA A A V G+ E +A + A A G GTGGG GG
Sbjct: 3 EEQFGGDGAAAAATAA------VGGSAGEQEGAMVAATQGAAAAAGSGAGTGGGTASGGT 56
Query: 857 EGGDAE 862
EGG AE
Sbjct: 57 EGGSAE 62
>gi|14110414 heterogeneous nuclear ribonucleoprotein D isoform c
[Homo sapiens]
Length = 306
Score = 37.7 bits (86), Expect = 0.049
Identities = 25/66 (37%), Positives = 30/66 (45%), Gaps = 8/66 (12%)
Query: 799 QEVVWGEGAGAGEPEAEEEGDFVNSGRGDAEAEALARSANALVRAQQGRGTGGGP--GGP 856
+E G+GA A A V G+ E +A + A A G GTGGG GG
Sbjct: 3 EEQFGGDGAAAAATAA------VGGSAGEQEGAMVAATQGAAAAAGSGAGTGGGTASGGT 56
Query: 857 EGGDAE 862
EGG AE
Sbjct: 57 EGGSAE 62
>gi|14110417 heterogeneous nuclear ribonucleoprotein D isoform b
[Homo sapiens]
Length = 336
Score = 37.7 bits (86), Expect = 0.049
Identities = 25/66 (37%), Positives = 30/66 (45%), Gaps = 8/66 (12%)
Query: 799 QEVVWGEGAGAGEPEAEEEGDFVNSGRGDAEAEALARSANALVRAQQGRGTGGGP--GGP 856
+E G+GA A A V G+ E +A + A A G GTGGG GG
Sbjct: 3 EEQFGGDGAAAAATAA------VGGSAGEQEGAMVAATQGAAAAAGSGAGTGGGTASGGT 56
Query: 857 EGGDAE 862
EGG AE
Sbjct: 57 EGGSAE 62
>gi|51477708 heterogeneous nuclear ribonucleoprotein D isoform d
[Homo sapiens]
Length = 287
Score = 37.7 bits (86), Expect = 0.049
Identities = 25/66 (37%), Positives = 30/66 (45%), Gaps = 8/66 (12%)
Query: 799 QEVVWGEGAGAGEPEAEEEGDFVNSGRGDAEAEALARSANALVRAQQGRGTGGGP--GGP 856
+E G+GA A A V G+ E +A + A A G GTGGG GG
Sbjct: 3 EEQFGGDGAAAAATAA------VGGSAGEQEGAMVAATQGAAAAAGSGAGTGGGTASGGT 56
Query: 857 EGGDAE 862
EGG AE
Sbjct: 57 EGGSAE 62
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.140 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,072,769
Number of Sequences: 37866
Number of extensions: 1933357
Number of successful extensions: 8427
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 27
Number of HSP's successfully gapped in prelim test: 76
Number of HSP's that attempted gapping in prelim test: 8060
Number of HSP's gapped (non-prelim): 309
length of query: 914
length of database: 18,247,518
effective HSP length: 111
effective length of query: 803
effective length of database: 14,044,392
effective search space: 11277646776
effective search space used: 11277646776
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.