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Search of human proteins with 31621305
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31621305 leucine-rich PPR motif-containing protein [Homo
sapiens]
(1394 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31621305 leucine-rich PPR motif-containing protein [Homo sapi... 2733 0.0
gi|38492358 pentatricopeptide repeat domain 1 [Homo sapiens] 45 6e-04
gi|42794779 myosin 18A isoform b [Homo sapiens] 41 0.007
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 40 0.012
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 40 0.020
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 40 0.020
gi|28416946 myosin 18A isoform a [Homo sapiens] 39 0.027
gi|116089292 tetratricopeptide repeat domain 21B [Homo sapiens] 39 0.027
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 39 0.046
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 38 0.059
gi|71061468 centromere protein E [Homo sapiens] 38 0.059
gi|22749429 coiled-coil domain containing 89 [Homo sapiens] 36 0.30
gi|222136607 tetratricopeptide repeat domain 26 isoform 3 [Homo ... 34 0.86
gi|237858621 polyamine modulated factor 1 binding protein 1 isof... 34 1.1
gi|237858619 polyamine modulated factor 1 binding protein 1 isof... 34 1.1
gi|51093830 bicaudal D homolog 1 isoform 2 [Homo sapiens] 34 1.1
gi|51039802 bicaudal D homolog 1 isoform 1 [Homo sapiens] 34 1.1
gi|98986331 pentatricopeptide repeat domain 2 [Homo sapiens] 34 1.1
gi|51479166 bicaudal D homolog 2 isoform 1 [Homo sapiens] 34 1.1
gi|21735417 bicaudal D homolog 2 isoform 2 [Homo sapiens] 34 1.1
gi|56961680 coiled-coil domain containing 147 [Homo sapiens] 34 1.1
gi|190194355 p90 autoantigen [Homo sapiens] 33 1.9
gi|118918407 spectrin repeat containing, nuclear envelope 2 isof... 33 1.9
gi|118918403 spectrin repeat containing, nuclear envelope 2 isof... 33 1.9
gi|9506557 Down syndrome critical region protein 6 [Homo sapiens] 33 1.9
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 33 2.5
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 33 2.5
gi|110347443 TATA element modulatory factor 1 [Homo sapiens] 32 3.3
gi|223029422 SKI-like isoform 3 [Homo sapiens] 32 4.3
gi|223029420 SKI-like isoform 2 [Homo sapiens] 32 4.3
>gi|31621305 leucine-rich PPR motif-containing protein [Homo sapiens]
Length = 1394
Score = 2733 bits (7085), Expect = 0.0
Identities = 1394/1394 (100%), Positives = 1394/1394 (100%)
Query: 1 MAALLRSARWLLRAGAAPRLPLSLRLLPGGPGRLHAASYLPAARAGPVAGGLLSPARLYA 60
MAALLRSARWLLRAGAAPRLPLSLRLLPGGPGRLHAASYLPAARAGPVAGGLLSPARLYA
Sbjct: 1 MAALLRSARWLLRAGAAPRLPLSLRLLPGGPGRLHAASYLPAARAGPVAGGLLSPARLYA 60
Query: 61 IAAKEKDIQEESTFSSRKISNQFDWALMRLDLSVRRTGRIPKKLLQKVFNDTCRSGGLGG 120
IAAKEKDIQEESTFSSRKISNQFDWALMRLDLSVRRTGRIPKKLLQKVFNDTCRSGGLGG
Sbjct: 61 IAAKEKDIQEESTFSSRKISNQFDWALMRLDLSVRRTGRIPKKLLQKVFNDTCRSGGLGG 120
Query: 121 SHALLLLRSCGSLLPELKLEERTEFAHRIWDTLQKLGAVYDVSHYNALLKVYLQNEYKFS 180
SHALLLLRSCGSLLPELKLEERTEFAHRIWDTLQKLGAVYDVSHYNALLKVYLQNEYKFS
Sbjct: 121 SHALLLLRSCGSLLPELKLEERTEFAHRIWDTLQKLGAVYDVSHYNALLKVYLQNEYKFS 180
Query: 181 PTDFLAKMEEANIQPNRVTYQRLIASYCNVGDIEGASKILGFMKTKDLPVTEAVFSALVT 240
PTDFLAKMEEANIQPNRVTYQRLIASYCNVGDIEGASKILGFMKTKDLPVTEAVFSALVT
Sbjct: 181 PTDFLAKMEEANIQPNRVTYQRLIASYCNVGDIEGASKILGFMKTKDLPVTEAVFSALVT 240
Query: 241 GHARAGDMENAENILTVMRDAGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVEKSELHL 300
GHARAGDMENAENILTVMRDAGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVEKSELHL
Sbjct: 241 GHARAGDMENAENILTVMRDAGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVEKSELHL 300
Query: 301 MDRDLLQIIFSFSKAGYPQYVSEILEKVTCERRYIPDAMNLILLLVTEKLEDVALQILLA 360
MDRDLLQIIFSFSKAGYPQYVSEILEKVTCERRYIPDAMNLILLLVTEKLEDVALQILLA
Sbjct: 301 MDRDLLQIIFSFSKAGYPQYVSEILEKVTCERRYIPDAMNLILLLVTEKLEDVALQILLA 360
Query: 361 CPVSKEDGPSVFGSFFLQHCVTMNTPVEKLTDYCKKLKEVQMHSFPLQFTLHCALLANKT 420
CPVSKEDGPSVFGSFFLQHCVTMNTPVEKLTDYCKKLKEVQMHSFPLQFTLHCALLANKT
Sbjct: 361 CPVSKEDGPSVFGSFFLQHCVTMNTPVEKLTDYCKKLKEVQMHSFPLQFTLHCALLANKT 420
Query: 421 DLAKALMKAVKEEGFPIRPHYFWPLLVGRRKEKNVQGIIEILKGMQELGVHPDQETYTDY 480
DLAKALMKAVKEEGFPIRPHYFWPLLVGRRKEKNVQGIIEILKGMQELGVHPDQETYTDY
Sbjct: 421 DLAKALMKAVKEEGFPIRPHYFWPLLVGRRKEKNVQGIIEILKGMQELGVHPDQETYTDY 480
Query: 481 VIPCFDSVNSARAILQENGCLSDSDMFSQAGLRSEAANGNLDFVLSFLKSNTLPISLQSI 540
VIPCFDSVNSARAILQENGCLSDSDMFSQAGLRSEAANGNLDFVLSFLKSNTLPISLQSI
Sbjct: 481 VIPCFDSVNSARAILQENGCLSDSDMFSQAGLRSEAANGNLDFVLSFLKSNTLPISLQSI 540
Query: 541 RSSLLLGFRRSMNINLWSEITELLYKDGRYCQEPRGPTEAVGYFLYNLIDSMSDSEVQAK 600
RSSLLLGFRRSMNINLWSEITELLYKDGRYCQEPRGPTEAVGYFLYNLIDSMSDSEVQAK
Sbjct: 541 RSSLLLGFRRSMNINLWSEITELLYKDGRYCQEPRGPTEAVGYFLYNLIDSMSDSEVQAK 600
Query: 601 EEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKNLDFQKTVQLT 660
EEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKNLDFQKTVQLT
Sbjct: 601 EEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKNLDFQKTVQLT 660
Query: 661 SSELESTLETLKAENQPIRDVLKQLILVLCSEENMQKALELKAKYESDMVTGGYAALINL 720
SSELESTLETLKAENQPIRDVLKQLILVLCSEENMQKALELKAKYESDMVTGGYAALINL
Sbjct: 661 SSELESTLETLKAENQPIRDVLKQLILVLCSEENMQKALELKAKYESDMVTGGYAALINL 720
Query: 721 CCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVGLVRVLAKHGKLQDAINILKEMKEKDVL 780
CCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVGLVRVLAKHGKLQDAINILKEMKEKDVL
Sbjct: 721 CCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVGLVRVLAKHGKLQDAINILKEMKEKDVL 780
Query: 781 IKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTLGLAEPSTNISFPLVTVHLEKGDLST 840
IKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTLGLAEPSTNISFPLVTVHLEKGDLST
Sbjct: 781 IKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTLGLAEPSTNISFPLVTVHLEKGDLST 840
Query: 841 ALEVAIDCYEKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMVMLYDLFFAFLQ 900
ALEVAIDCYEKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMVMLYDLFFAFLQ
Sbjct: 841 ALEVAIDCYEKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMVMLYDLFFAFLQ 900
Query: 901 TGNYKEAKKIIETPGIRARSARLQWFCDRCVANNQVETLEKLVELTQKLFECDRDQMYYN 960
TGNYKEAKKIIETPGIRARSARLQWFCDRCVANNQVETLEKLVELTQKLFECDRDQMYYN
Sbjct: 901 TGNYKEAKKIIETPGIRARSARLQWFCDRCVANNQVETLEKLVELTQKLFECDRDQMYYN 960
Query: 961 LLKLYKINGDWQRADAVWNKIQEENVIPREKTLRLLAEILREGNQEVPFDVPELWYEDEK 1020
LLKLYKINGDWQRADAVWNKIQEENVIPREKTLRLLAEILREGNQEVPFDVPELWYEDEK
Sbjct: 961 LLKLYKINGDWQRADAVWNKIQEENVIPREKTLRLLAEILREGNQEVPFDVPELWYEDEK 1020
Query: 1021 HSLNSSSASTTEPDFQKDILIACRLNQKKGAYDIFLNAKEQNIVFNAETYSNLIKLLMSE 1080
HSLNSSSASTTEPDFQKDILIACRLNQKKGAYDIFLNAKEQNIVFNAETYSNLIKLLMSE
Sbjct: 1021 HSLNSSSASTTEPDFQKDILIACRLNQKKGAYDIFLNAKEQNIVFNAETYSNLIKLLMSE 1080
Query: 1081 DYFTQAMEVKAFAETHIKGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRL 1140
DYFTQAMEVKAFAETHIKGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRL
Sbjct: 1081 DYFTQAMEVKAFAETHIKGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRL 1140
Query: 1141 AVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVFINNIALAQIKNNNIDAAIENI 1200
AVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVFINNIALAQIKNNNIDAAIENI
Sbjct: 1141 AVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVFINNIALAQIKNNNIDAAIENI 1200
Query: 1201 ENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQ 1260
ENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQ
Sbjct: 1201 ENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQ 1260
Query: 1261 LVDAGKVDDARALLQRCGAIAEQTPILLLFLLRNSRKQGKASTVKSVLELIPELNEKEEA 1320
LVDAGKVDDARALLQRCGAIAEQTPILLLFLLRNSRKQGKASTVKSVLELIPELNEKEEA
Sbjct: 1261 LVDAGKVDDARALLQRCGAIAEQTPILLLFLLRNSRKQGKASTVKSVLELIPELNEKEEA 1320
Query: 1321 YNSLMKSYVSEKDVTSAKALYEHLTAKNTKLDDLFLKRYASLLKYAGEPVPFIEPPESFE 1380
YNSLMKSYVSEKDVTSAKALYEHLTAKNTKLDDLFLKRYASLLKYAGEPVPFIEPPESFE
Sbjct: 1321 YNSLMKSYVSEKDVTSAKALYEHLTAKNTKLDDLFLKRYASLLKYAGEPVPFIEPPESFE 1380
Query: 1381 FYAQQLRKLRENSS 1394
FYAQQLRKLRENSS
Sbjct: 1381 FYAQQLRKLRENSS 1394
>gi|38492358 pentatricopeptide repeat domain 1 [Homo sapiens]
Length = 700
Score = 44.7 bits (104), Expect = 6e-04
Identities = 38/156 (24%), Positives = 71/156 (45%), Gaps = 12/156 (7%)
Query: 185 LAKMEEANIQPNRVTYQRLIASYCNVGDIEGASKILGFMKTKDLPVTEAVFSALVTGHAR 244
LA ++E ++ + + L+ +GD+EGA +L + + L F L G R
Sbjct: 508 LALLDEHQVEADLTFFNTLVRKKSKLGDLEGAKALLPVLAKRGLVPNLQTFCNLAIGCHR 567
Query: 245 AGDMENAENILTVMRDAGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVEKSELHLMDRD 304
D +LT M+ + + P Y AL+NA K + ++ L+ ++++ + + +
Sbjct: 568 PKD---GLQLLTDMKKSQVTPNTHIYSALINAAIRKLNYTYLISILKDMKQNRVPVNEVV 624
Query: 305 LLQIIFSFSKAGYP------QYVSEILEKVTCERRY 334
+ Q+ F+ A YP Q + LEK+ R Y
Sbjct: 625 IRQLEFA---AQYPPTFDRYQGKNTYLEKIDGFRAY 657
Score = 38.1 bits (87), Expect = 0.059
Identities = 22/73 (30%), Positives = 36/73 (49%)
Query: 223 MKTKDLPVTEAVFSALVTGHARAGDMENAENILTVMRDAGIEPGPDTYLALLNAYAEKGD 282
+K + L E+ ++ L+ G R G ++ A N+ M+ +EP TY AL N AE
Sbjct: 164 LKEERLQPMESNYTVLIGGCGRVGYLKKAFNLYNQMKKRDLEPSDATYTALFNVCAESPW 223
Query: 283 IDHVKQTLEKVEK 295
D Q+ K+ +
Sbjct: 224 KDSALQSALKLRQ 236
Score = 36.6 bits (83), Expect = 0.17
Identities = 84/444 (18%), Positives = 164/444 (36%), Gaps = 57/444 (12%)
Query: 146 AHRIWDTLQKLGAVYDVSHYNALLKVYLQNEYKFSPTDFLAKMEEA----NIQPNRVTYQ 201
A +++ ++K + Y AL V ++ +K S K+ + N + N TY
Sbjct: 192 AFNLYNQMKKRDLEPSDATYTALFNVCAESPWKDSALQSALKLRQQLQAKNFELNLKTYH 251
Query: 202 RLIASYCNVGDIEGASKILGFMKTKDLPVTEAVFSALVTG--HARAGDMENAENILTVMR 259
L+ D+ + + K VTE FS L+ G + A + +M
Sbjct: 252 ALLKMAAKCADLRMCLDVFKEIIHKGHVVTEETFSFLLMGCIQDKKTGFRYALQVWRLML 311
Query: 260 DAGIEPGPDTYLALLNAYAE--KGDIDHVKQTLEKVEKSELHLMDRDLLQIIFSFSKAGY 317
G++P D+Y LL A + GD + L K + L Q ++A
Sbjct: 312 SLGLQPSRDSYNLLLVAARDCGLGDPQVASELLLKPREEATVLQPPVSRQRPRRTAQAKA 371
Query: 318 PQYVSEILEKVTCERRYI------------PDAM-----------------NLILLLVTE 348
+S +L ER+ P+A L V
Sbjct: 372 GNLMSAMLHVEALERQLFLEPSQALGPPEPPEARVPGKAQPEVDTKAEPSHTAALTAVAL 431
Query: 349 KLEDVALQILLACPVSKEDGPSVFGSFFLQHCVTMNTPVEKLT------DYCKKLKEVQM 402
K V L++ L P + FG T+ TP ++L + K+ E +
Sbjct: 432 KPPPVELEVNLLTPGAVPPTVVSFG--------TVTTPADRLALIGGLEGFLSKMAEHRQ 483
Query: 403 HSFPLQFTLHCALLANKTDLAKALMKAVKEEGFPIRPHYFWPLLVGRRKEKNVQGIIEIL 462
TL ++ + + L+ + E +F L+ + K +++G +L
Sbjct: 484 QPDIRTLTLLAEVVESGSPAESLLLALLDEHQVEADLTFFNTLVRKKSKLGDLEGAKALL 543
Query: 463 KGMQELGVHPDQETYTDYVIPCFDSVNSARAI--LQENGCLSDSDMFSQAGLRSEAANGN 520
+ + G+ P+ +T+ + I C + + + ++++ ++ ++S A + + N
Sbjct: 544 PVLAKRGLVPNLQTFCNLAIGCHRPKDGLQLLTDMKKSQVTPNTHIYS-ALINAAIRKLN 602
Query: 521 LDFVLSFL---KSNTLPISLQSIR 541
+++S L K N +P++ IR
Sbjct: 603 YTYLISILKDMKQNRVPVNEVVIR 626
Score = 34.7 bits (78), Expect = 0.66
Identities = 26/100 (26%), Positives = 46/100 (46%), Gaps = 4/100 (4%)
Query: 188 MEEANIQPNRVTYQRLIASYCNVGDIEGASKILGFMKTKDLPVTEAVFSALVTGHARA-- 245
++E +QP Y LI VG ++ A + MK +DL ++A ++AL A +
Sbjct: 164 LKEERLQPMESNYTVLIGGCGRVGYLKKAFNLYNQMKKRDLEPSDATYTALFNVCAESPW 223
Query: 246 --GDMENAENILTVMRDAGIEPGPDTYLALLNAYAEKGDI 283
+++A + ++ E TY ALL A+ D+
Sbjct: 224 KDSALQSALKLRQQLQAKNFELNLKTYHALLKMAAKCADL 263
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 41.2 bits (95), Expect = 0.007
Identities = 101/495 (20%), Positives = 199/495 (40%), Gaps = 81/495 (16%)
Query: 595 SEVQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKNLDFQ 654
S+ E L + QL + K+ + L E ++++ A L +E ++ +
Sbjct: 1528 SQESKDEASLAKVKKQLRDLEAKVKDQE----EELDEQAGTIQMLEQAKLRLE---MEME 1580
Query: 655 KTVQLTSSELESTLETLKAENQPIRDVLKQLILVLCSE-ENMQKALELKAKYESDMVTGG 713
+ Q S E+ES E ++ Q + LKQ+ + L E E+ QK L K + E + T
Sbjct: 1581 RMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLAT-- 1638
Query: 714 YAALINLCCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVGLVRVLAKHGKLQDAINILKE 773
L ++ +R D + + K+
Sbjct: 1639 -------------------LSDQVNRRD----------------------FESEKRLRKD 1657
Query: 774 MKEKDVLIKDTTALSFFHMLNGAALRGEIETVK-QLHEAIVTLGLAEPSTN-ISFPLVTV 831
+K L+ D L H+ N A + EI +K QL E+ T A + + + +
Sbjct: 1658 LKRTKALLAD-AQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDL 1716
Query: 832 HLEKGDLS---TALEVAIDCYEKYKVLPRIHDVLCKLVEKGE--TDLIQKAMDFVSQEQG 886
HL+ D++ TALE + ++ K +++ +L E E +L++K V+Q
Sbjct: 1717 HLQIDDIAKAKTALEEQLSRLQREK-----NEIQNRLEEDQEDMNELMKKHKAAVAQASR 1771
Query: 887 EMVMLYDLFFAFLQTGNYKEAKKIIETPGIRARSARLQWFCDRCVANNQVETLEKLVELT 946
++ + DL A L+ N KE +++ E ++A +++++ V + V E +
Sbjct: 1772 DLAQINDL-QAQLEEAN-KEKQELQEK--LQALQSQVEFLEQSMVDKSLVSRQEAKIREL 1827
Query: 947 QKLFECDRDQM-----YYNLLK--LYKINGDWQRADAVWNKIQEENVIPREKTLRLLAEI 999
+ E +R Q+ + LK + K+ + + A N+ +E+N K L+
Sbjct: 1828 ETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQN-----KRLQRQLRD 1882
Query: 1000 LREGNQEVPFDVPELWYEDEKHSLNSSSASTTEPDFQKDILIAC-RLNQKKGAYDIFLNA 1058
+E E+ E + + ++ S Q D+ +A R+ + A + + +
Sbjct: 1883 TKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMES 1942
Query: 1059 KEQNIVFNAETYSNL 1073
E + N+E S++
Sbjct: 1943 DENEDLINSEGDSDV 1957
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 40.4 bits (93), Expect = 0.012
Identities = 95/470 (20%), Positives = 183/470 (38%), Gaps = 84/470 (17%)
Query: 591 SMSDSEVQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKN 650
SM +++Q + + L QL+K G+ L S+ E ++ ++ ++ +N
Sbjct: 717 SMKMAQLQLENKELESEKEQLKK-----------GLELLKASFKKTERLEVSYQGLDIEN 765
Query: 651 LDFQKTVQLTSS---ELESTLETLKAENQPIRDVLKQLILVLCSEENMQKALELKAKYES 707
QKT++ ++ +LES L+ L+ ENQ ++ L++L + E ++K + + S
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETS 825
Query: 708 DMVTGGYAALINLCCRHDKVEDALNLKEEFDRLDSSA-VLDTGKYVGLVRV--LAKHGK- 763
+ +D L++E RL A + DT V++ L K K
Sbjct: 826 QL-----------------EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKT 868
Query: 764 LQDAINILKEM--------KEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTL 815
L I I KE KE L+K T +I+T+ L E +V+
Sbjct: 869 LSKEIGIYKESCVRLKELEKENKELVKRATI--------------DIKTLVTLREDLVSE 914
Query: 816 GLAEPSTNISFPLVTVHLEKGDLS--TALEVAIDCYEKYKVL-PRIHDVLCKLVEKGETD 872
L N +T LEK L+ L ++YK+L ++ L K +E E
Sbjct: 915 KLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEK 974
Query: 873 L------IQKAMDFVSQEQGEMVMLYDLFFAFLQTGNYKEAKKIIETPGIRARSARLQWF 926
+ ++++ ++ Q + E+ + + A Q E + + +P I + +
Sbjct: 975 IAALEARLEESTNYNQQLRQELKTVKKNYEALKQ--RQDEERMVQSSPPISGEDNKWE-- 1030
Query: 927 CDRCVANNQVETLEKLVELTQKLFECDRDQMYYNLLKLYKINGDWQRADAVWNKIQEENV 986
ET +L+++ +L E +R+ + + Q +++ +N
Sbjct: 1031 ------RESQETTRELLKVKDRLIEVERNNA--------TLQAEKQALKTQLKQLETQNN 1076
Query: 987 IPREKTLRLLAEILREGNQEVPFDVPELWYEDEKHSLNSSSASTTEPDFQ 1036
+ + L L + + Q + E +LNS S S + Q
Sbjct: 1077 NLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQ 1126
Score = 34.7 bits (78), Expect = 0.66
Identities = 109/533 (20%), Positives = 206/533 (38%), Gaps = 87/533 (16%)
Query: 913 TPGIRARSARLQWFCDRCVANNQVETL-EKLVELTQKLFECDRD--QMYYNLLKLYKING 969
+PG++ +R + A ++ L ++L E T++L +C ++ QM L +L + N
Sbjct: 237 SPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENM 296
Query: 970 DWQRADAVWNKIQEENVIPREKTLR---LLAEILREGNQEVPFDVPELWYEDEKHSLNSS 1026
+ ++E REK +R L +E+ R Y++ H +
Sbjct: 297 NLLSDARSARMYRDELDALREKAVRVDKLESEVSR--------------YKERLHDIEFY 342
Query: 1027 SASTTEPDFQKDILIACR------LNQKKGAYDIFLNAKEQNIVFNAETYS--------- 1071
A E +L+ + L + D +++N+ A+ +
Sbjct: 343 KARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDR 402
Query: 1072 NLIKLLMSEDYFTQAMEVKAFAETHIKGFTL---------------------NDAANSRL 1110
I+ LM E+ + + ++ E+ G+ L N+ +SRL
Sbjct: 403 KKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRL 462
Query: 1111 IITQVRRDYLKEAVTTLKTVLD--QQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGL 1168
+ ++ L + V L+T +D + L + + Q L+ K ++ E+VQ+ L
Sbjct: 463 LKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEK-QSL 521
Query: 1169 EDSIGLSKMVFINNIALAQIKNNNIDAAIENIE---NMLTSENKVIEPQYFGLAYLFRKV 1225
++ LSK + L I+ EN E +L EN+ + L +
Sbjct: 522 QNCQNLSKDLMKEKAQL----EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQIS 577
Query: 1226 IEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKVDDARAL--LQRCGAIAEQ 1283
E +++ ++ I+ E + T L ++ K + L + G AE+
Sbjct: 578 AEARVKDIEKENKILHESIKE--------TSSKLSKIEFEKRQIKKELEHYKEKGERAEE 629
Query: 1284 TPILLLFLLR-NSRKQGKASTVKSVLELIPEL----NEKEEAYNSLMKSYVSEKDVTSAK 1338
L L + N Q K + +K E I L +E E L K+ S K++T
Sbjct: 630 LENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQ- 688
Query: 1339 ALYEHLTAKNTKLDD--LFLKRYASLLKYAGEPVPFIE-PPESFEFYAQQLRK 1388
E L +N++LD+ L L+R LK A + ++ + E +QL+K
Sbjct: 689 --LESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKK 739
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 39.7 bits (91), Expect = 0.020
Identities = 85/429 (19%), Positives = 180/429 (41%), Gaps = 47/429 (10%)
Query: 597 VQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKNLDFQKT 656
VQ K+E +RQ+ Q+E+M + + +R+ + IK ++ + N+ Q T
Sbjct: 446 VQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDT 505
Query: 657 ---VQLTSSELESTLETLKAENQPIRDVLKQLILVLCSEENMQKALELKAKYESDMVTGG 713
+ EL LE A + + D++++L S E +Q+A + A+ ES +
Sbjct: 506 NSQKEKLKEELGLILEEKCALQRQLEDLVEELSF---SREQIQRARQTIAEQESKL---- 558
Query: 714 YAALINLCCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVGLVRVLAKHGKLQDAINILKE 773
A +L D + ++ E L+ + Y + +L K + ++ + E
Sbjct: 559 NEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEK--EKNAVLDRMAE 616
Query: 774 MKEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLH--EAIVTLGLAEP------STNIS 825
+E + L + T L F H + L+ ++E +++ + LG+ +S
Sbjct: 617 SQEAE-LERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMS 675
Query: 826 FPLVTVHLEKGDLSTALEVAIDCYEKYKVLPRIHDVLCKLVEKGETDL------IQKAMD 879
+ T+ EK +L T I + ++ D+ LV ++ +QK ++
Sbjct: 676 QKIETMQFEKDNLITKQNQLI------LEISKLKDLQQSLVNSKSEEMTLQINELQKEIE 729
Query: 880 FVSQEQGEMVMLYDLFFAFLQTGNYKEAKKIIETPGIRARSARLQWFCDRCVANNQVETL 939
+ QE+ E L E + + ++ + A+L+ + + ++ +TL
Sbjct: 730 ILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLE--AENSILKDEKKTL 787
Query: 940 EKLVELTQKLFECDRDQMYYNLLKLYKINGDWQRADAVWNK----IQEENVIPREKTLRL 995
E ++++ + + +R L+ L I + D+VW K + EEN +++ ++L
Sbjct: 788 EDMLKIHTPVSQEER------LIFLDSIKS--KSKDSVWEKEIEILIEENEDLKQQCIQL 839
Query: 996 LAEILREGN 1004
EI ++ N
Sbjct: 840 NEEIEKQRN 848
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 39.7 bits (91), Expect = 0.020
Identities = 85/429 (19%), Positives = 180/429 (41%), Gaps = 47/429 (10%)
Query: 597 VQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKNLDFQKT 656
VQ K+E +RQ+ Q+E+M + + +R+ + IK ++ + N+ Q T
Sbjct: 446 VQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDT 505
Query: 657 ---VQLTSSELESTLETLKAENQPIRDVLKQLILVLCSEENMQKALELKAKYESDMVTGG 713
+ EL LE A + + D++++L S E +Q+A + A+ ES +
Sbjct: 506 NSQKEKLKEELGLILEEKCALQRQLEDLVEELSF---SREQIQRARQTIAEQESKL---- 558
Query: 714 YAALINLCCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVGLVRVLAKHGKLQDAINILKE 773
A +L D + ++ E L+ + Y + +L K + ++ + E
Sbjct: 559 NEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEK--EKNAVLDRMAE 616
Query: 774 MKEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLH--EAIVTLGLAEP------STNIS 825
+E + L + T L F H + L+ ++E +++ + LG+ +S
Sbjct: 617 SQEAE-LERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMS 675
Query: 826 FPLVTVHLEKGDLSTALEVAIDCYEKYKVLPRIHDVLCKLVEKGETDL------IQKAMD 879
+ T+ EK +L T I + ++ D+ LV ++ +QK ++
Sbjct: 676 QKIETMQFEKDNLITKQNQLI------LEISKLKDLQQSLVNSKSEEMTLQINELQKEIE 729
Query: 880 FVSQEQGEMVMLYDLFFAFLQTGNYKEAKKIIETPGIRARSARLQWFCDRCVANNQVETL 939
+ QE+ E L E + + ++ + A+L+ + + ++ +TL
Sbjct: 730 ILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLE--AENSILKDEKKTL 787
Query: 940 EKLVELTQKLFECDRDQMYYNLLKLYKINGDWQRADAVWNK----IQEENVIPREKTLRL 995
E ++++ + + +R L+ L I + D+VW K + EEN +++ ++L
Sbjct: 788 EDMLKIHTPVSQEER------LIFLDSIKS--KSKDSVWEKEIEILIEENEDLKQQCIQL 839
Query: 996 LAEILREGN 1004
EI ++ N
Sbjct: 840 NEEIEKQRN 848
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 39.3 bits (90), Expect = 0.027
Identities = 79/371 (21%), Positives = 151/371 (40%), Gaps = 68/371 (18%)
Query: 595 SEVQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKNLDFQ 654
S+ E L + QL + K+ + L E ++++ A L +E ++ +
Sbjct: 1528 SQESKDEASLAKVKKQLRDLEAKVKDQE----EELDEQAGTIQMLEQAKLRLE---MEME 1580
Query: 655 KTVQLTSSELESTLETLKAENQPIRDVLKQLILVLCSE-ENMQKALELKAKYESDMVTGG 713
+ Q S E+ES E ++ Q + LKQ+ + L E E+ QK L K + E + T
Sbjct: 1581 RMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLAT-- 1638
Query: 714 YAALINLCCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVGLVRVLAKHGKLQDAINILKE 773
L ++ +R D + + K+
Sbjct: 1639 -------------------LSDQVNRRD----------------------FESEKRLRKD 1657
Query: 774 MKEKDVLIKDTTALSFFHMLNGAALRGEIETVK-QLHEAIVTLGLAEPSTN-ISFPLVTV 831
+K L+ D L H+ N A + EI +K QL E+ T A + + + +
Sbjct: 1658 LKRTKALLAD-AQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDL 1716
Query: 832 HLEKGDLS---TALEVAIDCYEKYKVLPRIHDVLCKLVEKGE--TDLIQKAMDFVSQEQG 886
HL+ D++ TALE + ++ K +++ +L E E +L++K V+Q
Sbjct: 1717 HLQIDDIAKAKTALEEQLSRLQREK-----NEIQNRLEEDQEDMNELMKKHKAAVAQASR 1771
Query: 887 EMVMLYDLFFAFLQTGNYKEAKKIIETPGIRARSARLQWFCDRCVANNQVETLEKLVELT 946
++ + DL A L+ N KE +++ E ++A +++++ V + V E +
Sbjct: 1772 DLAQINDL-QAQLEEAN-KEKQELQEK--LQALQSQVEFLEQSMVDKSLVSRQEAKIREL 1827
Query: 947 QKLFECDRDQM 957
+ E +R Q+
Sbjct: 1828 ETRLEFERTQV 1838
>gi|116089292 tetratricopeptide repeat domain 21B [Homo sapiens]
Length = 1316
Score = 39.3 bits (90), Expect = 0.027
Identities = 34/144 (23%), Positives = 67/144 (46%), Gaps = 4/144 (2%)
Query: 1098 KGFTLNDAAN---SRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTRVIQALAMKGD 1154
+ F+LN + + L + + +KEA+ KT + +T S A+ IQ ++G
Sbjct: 315 RAFSLNPQQSEFATELGYQMILQGRVKEALKWYKTAMTLDET-SVSALVGFIQCQLIEGQ 373
Query: 1155 VENIEVVQKMLNGLEDSIGLSKMVFINNIALAQIKNNNIDAAIENIENMLTSENKVIEPQ 1214
+++ + + LN ++ SIG S + + LA KN + I + ++L + +E
Sbjct: 374 LQDADQQLEFLNEIQQSIGKSAELIYLHAVLAMKKNKRQEEVINLLNDVLDTHFSQLEGL 433
Query: 1215 YFGLAYLFRKVIEEQLEPAVEKIS 1238
G+ Y + + LE +E +S
Sbjct: 434 PLGIQYFEKLNPDFLLEIVMEYLS 457
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 38.5 bits (88), Expect = 0.046
Identities = 96/472 (20%), Positives = 184/472 (38%), Gaps = 87/472 (18%)
Query: 591 SMSDSEVQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKN 650
SM +++Q + + L QL+K G+ L S+ E ++ ++ ++ +N
Sbjct: 717 SMKMAQLQLENKELESEKEQLKK-----------GLELLKASFKKTERLEVSYQGLDIEN 765
Query: 651 LDFQKTVQLTSS---ELESTLETLKAENQPIRDVLKQLILVLCSEENMQKALELKAKYES 707
QKT++ ++ +LES L+ L+ ENQ ++ L++L + E ++K + + S
Sbjct: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETS 825
Query: 708 DMVTGGYAALINLCCRHDKVEDALNLKEEFDRLDSSA-VLDTGKYVGLVRV--LAKHGK- 763
+ +D L++E RL A + DT V++ L K K
Sbjct: 826 QL-----------------EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKT 868
Query: 764 LQDAINILKEM--------KEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTL 815
L I I KE KE L+K T +I+T+ L E +V+
Sbjct: 869 LSKEIGIYKESCVRLKELEKENKELVKRATI--------------DIKTLVTLREDLVSE 914
Query: 816 GLAEPSTNISFPLVTVHLEKGDLSTAL----EVAIDCYEKYKVL-PRIHDVLCKLVEKGE 870
L N +T LEK L+ E + D +YK+L ++ L K +E E
Sbjct: 915 KLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTD-DSRYKLLESKLESTLKKSLEIKE 973
Query: 871 TDL------IQKAMDFVSQEQGEMVMLYDLFFAFLQTGNYKEAKKIIETPGIRARSARLQ 924
+ ++++ ++ Q + E+ + + A Q E + + +P I + +
Sbjct: 974 EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQ--RQDEERMVQSSPPISGEDNKWE 1031
Query: 925 WFCDRCVANNQVETLEKLVELTQKLFECDRDQMYYNLLKLYKINGDWQRADAVWNKIQEE 984
ET +L+++ +L E +R+ + + Q +++ +
Sbjct: 1032 --------RESQETTRELLKVKDRLIEVERNNA--------TLQAEKQALKTQLKQLETQ 1075
Query: 985 NVIPREKTLRLLAEILREGNQEVPFDVPELWYEDEKHSLNSSSASTTEPDFQ 1036
N + + L L + + Q + E +LNS S S + Q
Sbjct: 1076 NNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQ 1127
Score = 34.7 bits (78), Expect = 0.66
Identities = 109/533 (20%), Positives = 206/533 (38%), Gaps = 87/533 (16%)
Query: 913 TPGIRARSARLQWFCDRCVANNQVETL-EKLVELTQKLFECDRD--QMYYNLLKLYKING 969
+PG++ +R + A ++ L ++L E T++L +C ++ QM L +L + N
Sbjct: 237 SPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENM 296
Query: 970 DWQRADAVWNKIQEENVIPREKTLR---LLAEILREGNQEVPFDVPELWYEDEKHSLNSS 1026
+ ++E REK +R L +E+ R Y++ H +
Sbjct: 297 NLLSDARSARMYRDELDALREKAVRVDKLESEVSR--------------YKERLHDIEFY 342
Query: 1027 SASTTEPDFQKDILIACR------LNQKKGAYDIFLNAKEQNIVFNAETYS--------- 1071
A E +L+ + L + D +++N+ A+ +
Sbjct: 343 KARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDR 402
Query: 1072 NLIKLLMSEDYFTQAMEVKAFAETHIKGFTL---------------------NDAANSRL 1110
I+ LM E+ + + ++ E+ G+ L N+ +SRL
Sbjct: 403 KKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRL 462
Query: 1111 IITQVRRDYLKEAVTTLKTVLD--QQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGL 1168
+ ++ L + V L+T +D + L + + Q L+ K ++ E+VQ+ L
Sbjct: 463 LKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEK-QSL 521
Query: 1169 EDSIGLSKMVFINNIALAQIKNNNIDAAIENIE---NMLTSENKVIEPQYFGLAYLFRKV 1225
++ LSK + L I+ EN E +L EN+ + L +
Sbjct: 522 QNCQNLSKDLMKEKAQL----EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQIS 577
Query: 1226 IEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKVDDARAL--LQRCGAIAEQ 1283
E +++ ++ I+ E + T L ++ K + L + G AE+
Sbjct: 578 AEARVKDIEKENKILHESIKE--------TSSKLSKIEFEKRQIKKELEHYKEKGERAEE 629
Query: 1284 TPILLLFLLR-NSRKQGKASTVKSVLELIPEL----NEKEEAYNSLMKSYVSEKDVTSAK 1338
L L + N Q K + +K E I L +E E L K+ S K++T
Sbjct: 630 LENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQ- 688
Query: 1339 ALYEHLTAKNTKLDD--LFLKRYASLLKYAGEPVPFIE-PPESFEFYAQQLRK 1388
E L +N++LD+ L L+R LK A + ++ + E +QL+K
Sbjct: 689 --LESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKK 739
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 38.1 bits (87), Expect = 0.059
Identities = 139/706 (19%), Positives = 270/706 (38%), Gaps = 109/706 (15%)
Query: 585 LYNLIDSMSDSEVQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDAHL 644
L N+I + + Q ++H + K+ E I R R L Y E I++
Sbjct: 214 LQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTE-ISRRHREELSDYE--ERIEELEN 270
Query: 645 LVE-----------SKNLDFQKTVQLTSSELESTLETLKAENQPIRDVLKQLILVLCSEE 693
L++ SK + QKT+Q+ E + + ++ I+D+ K+L S E
Sbjct: 271 LLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKL----SSAE 326
Query: 694 NMQKALELKAKYESDMVTGGYAALINLCCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVG 753
N + L + + +N+ R +E+ NLK E +L SAV +
Sbjct: 327 NDRDILRREQEQ------------LNVEKRQI-MEECENLKLECSKLQPSAVKQSDTMTE 373
Query: 754 LVRVLAKHGKLQDAINILKEM----------------------------------KEKDV 779
R+LA+ +++ + + + KEK +
Sbjct: 374 KERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSL 433
Query: 780 LIKDTTALSF--------FHMLNGAALRGEIETVKQLHEAIVTLGLAEPSTNISFPLVTV 831
L ++ L + ++ A R +I +LH+ + L E N S
Sbjct: 434 LSQEKEELQMSLLKLNNEYEVIKSTATR-DISLDSELHDLRLNLEAKEQELNQSIS---- 488
Query: 832 HLEKGDLSTAL-EVAIDCYEKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMVM 890
EK L + E+ E K + I D L K +G++ +I K ++ E+ +
Sbjct: 489 --EKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDS-IISKLKQDLNDEKKRVHQ 545
Query: 891 LYDLFFAFLQTGNYKEAKKIIETPGIRARSARLQWFCDRCVANNQVETLEKLVELTQKLF 950
L D + + ++ K I + Q D+ N V+ L K E +
Sbjct: 546 LEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDK--VENLVDQLNKSQESNVSIQ 603
Query: 951 ECD---RDQMYYNLLKLYKINGDWQRA---DAVWNKIQEENVIPREKTLRLL------AE 998
+ + ++ + N +L +I + ++ D+ N ++ + RE +R L E
Sbjct: 604 KENLELKEHIRQNEEELSRIRNELMQSLNQDSNSN-FKDTLLKEREAEVRNLKQNLSELE 662
Query: 999 ILREGNQEVPFDVP------ELWYEDEKHSLNSSSASTTEPDFQKDILIACRLNQKKGAY 1052
L E ++V FDV L ED +H L A + +K+ ++ L +KG
Sbjct: 663 QLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVE-TLKMEKGEI 721
Query: 1053 DIFLNAKEQNIVFNAETYSNLI-KLLMSEDYFTQAMEVKAFAETHIKGFTLNDAANSRLI 1111
+ L ++ ++ A Y I +L + + T A++++ + + A +
Sbjct: 722 EAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKN 781
Query: 1112 ITQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTRVIQALAMKGDVENI-EVVQKMLNGLED 1170
I Q+ D+ KE L + L++Q+ ++L + I +K + E + K L
Sbjct: 782 IEQMDTDH-KETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRK 840
Query: 1171 SIGLSKMVFINNIALAQIK--NNNIDAAIENIENMLTSENKVIEPQ 1214
+ L + + + +L +K NN++ +E + + V +P+
Sbjct: 841 NEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPK 886
Score = 37.0 bits (84), Expect = 0.13
Identities = 100/555 (18%), Positives = 218/555 (39%), Gaps = 106/555 (19%)
Query: 587 NLIDSMSDSE-----VQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKD 641
NL+D ++ S+ +Q + L+++ Q E+ +I + + + S L+K+
Sbjct: 587 NLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKE 646
Query: 642 AHLLVESKNLDFQKTVQLTSSELESTLETLKAENQPI----RDVLKQLILVLCSEENMQK 697
V + + + QL + L+ +K EN+ + DV QL C N Q
Sbjct: 647 REAEVRNLKQNLSELEQLNEN-LKKVAFDVKMENEKLVLACEDVRHQL--EECLAGNNQL 703
Query: 698 ALELKAKYESDMVTGGYAALINLCCRHDKVEDALNLKEEFDRLDSSAVLDTG----KYVG 753
+LE E+ + G + +E+A ++ + L ++ L+T ++
Sbjct: 704 SLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEH 763
Query: 754 LVRVLAKHGKLQDAINILKEMKEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLHEAIV 813
L+++ K K + + K +++ D K+T + L +E KQL + I
Sbjct: 764 LIKLNQK--KDMEIAELKKNIEQMDTDHKETKDV----------LSSSLEEQKQLTQLIN 811
Query: 814 TLGLAEPSTNISFPLVTVHLEK-GDLSTALEVAIDCYEKYKVLPRIHDVLCKLVE----- 867
+ +EK + S+ L+ +D KY R +++L + +E
Sbjct: 812 KK--------------EIFIEKLKERSSKLQEELD---KYSQALRKNEILRQTIEEKDRS 854
Query: 868 ----KGETDLIQKAMDFVSQEQGEMVMLYDLFFAFLQTGNYKEAKKIIETPGIRARSARL 923
K E + +Q+ ++ + +EQ +T + K + + + ++L
Sbjct: 855 LGSMKEENNHLQEELERLREEQS-------------RTAPVADPKTLDSVTELASEVSQL 901
Query: 924 QWFCDRCVANNQVETLEKLVELTQKLFECDRDQMYYNLLK--------LYKINGDWQRAD 975
N E LE+ ++ QK+ E D++Q LL+ + + ++ +
Sbjct: 902 ---------NTIKEHLEEEIKHHQKIIE-DQNQSKMQLLQSLQEQKKEMDEFRYQHEQMN 951
Query: 976 AVWNKI---QEENVIPREKTLRLLAEILREGNQEVPFDVPELWYE-----------DEKH 1021
A ++ ++E + +KT+ + L E Q++ D +++ E EKH
Sbjct: 952 ATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKH 1011
Query: 1022 SLNSSSASTTEPDFQKDILIACRLNQKKGAYDIFLNAKEQNIVFNAETYSNLIKLLMSED 1081
L+ + ++ L LN+K ++ +Q + + L +++ +D
Sbjct: 1012 DLSKAETERLVKGIKERELEIKLLNEKN------ISLTKQIDQLSKDEVGKLTQIIQQKD 1065
Query: 1082 YFTQAMEVKAFAETH 1096
QA+ + + +H
Sbjct: 1066 LEIQALHARISSTSH 1080
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 38.1 bits (87), Expect = 0.059
Identities = 177/855 (20%), Positives = 331/855 (38%), Gaps = 153/855 (17%)
Query: 594 DSEVQAKEEHLRQYFHQLEKMNVKIP----ENIYRGIRNLLESYHVPELIKDAHLLVESK 649
++E+ +K E LR+ Q++K+ I ENI + LES P+ +K E+
Sbjct: 574 ENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETV 633
Query: 650 NLDFQKTVQLTSSELESTLETLKAENQPIRDVLKQLILVLCSEEN----MQKALELKAKY 705
LD ++ ES L++EN +++ +K+L EN Q LE K K
Sbjct: 634 ALDAKR---------ESAF--LRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKM 682
Query: 706 ESDMVTGGYAALINLCCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVGLVRVLAKHGKLQ 765
+ D+ +++ A N E +L S ++D L+ L GK+
Sbjct: 683 QVDL--------------EKELQSAFN---EITKLTS--LIDGKVPKDLLCNLELEGKIT 723
Query: 766 DAINIL-KEMKEKDVLIKDTTALSFFHMLNGAA--LRGEI-ETVKQLHEAIVT------- 814
D L KE++E + L ++ LS L LR EI + ++LH I+T
Sbjct: 724 DLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELH--IITSEKDKLF 781
Query: 815 LGLAEPSTNISFPLVTVHLEKGDLSTA---LEVAIDCYEKYKVLPRIHDVLCKLVEKGET 871
+ + + L + K DL+T + ++ +K L + K+V +
Sbjct: 782 SEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENE 841
Query: 872 DLIQKAMDFVSQEQGEMVMLYDLFFAFLQTG-NYKEAKKIIETPGIRARSARLQWFCDR- 929
+ Q+ ++ + Q +D L+T +YK + +T ++ R ++ ++
Sbjct: 842 RMNQEIVNLSKEAQ-----KFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQL 896
Query: 930 ---------------CVANNQVETLEKLVELT---------QKLFECDRDQMYYNLLKLY 965
+ +TLE++ LT Q+ + +RDQ+ ++
Sbjct: 897 ENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTV 956
Query: 966 KINGDWQR--ADAVWNKIQEENVIPREKTLRLLAEILREGNQEVPFDVPELWYE------ 1017
+N D Q +A+ + Q + I K+ ++ E+ R + E + ++
Sbjct: 957 NMNIDTQEQLRNALESLKQHQETINTLKS-KISEEVSRNLHMEENTGETKDEFQQKMVGI 1015
Query: 1018 DEKHSLNSSSASTTEPDFQKDILIACR-----LNQKKGAYDIFLNA----KEQ---NIVF 1065
D+K L + + T D + + +I + L Q+K L + KEQ ++
Sbjct: 1016 DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKE 1075
Query: 1066 NAE-TYSNLIKLLMSEDYFTQAMEVKAFAETHIKGFTLNDAANSRLIITQVRRDYLKEAV 1124
N E T N +L + D + E+ A + H + SR D L E
Sbjct: 1076 NIEMTIENQEELRLLGDELKKQQEIVAQEKNHA---IKKEGELSRTC------DRLAEVE 1126
Query: 1125 TTLKTVLDQQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVFINNIA 1184
LK Q Q + + + M+ + IE ++ L E ++ + + +
Sbjct: 1127 EKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTL---EHMETERLE 1183
Query: 1185 LAQIKNNNID--AAIENIENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVE-KIS--I 1239
LAQ N N + +I +L K E + L R++ L+ E KI+
Sbjct: 1184 LAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIH 1243
Query: 1240 MAERLANQFAIYKPVTDFFLQLVDAGKVDDARALLQRCGAIAEQTPIL--LLFLLRNSRK 1297
+ E + + V++ Q+++ ++ + LQ E+ P+L LL N ++
Sbjct: 1244 LKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQ------EEIPVLHEEQELLPNVKE 1297
Query: 1298 QGKASTVKSVLELIPE-------------------LNEKEEAYNSLMKSYVSEKDVTSAK 1338
+ + LEL+ E LNEK + +KS E+D + K
Sbjct: 1298 VSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERD--NLK 1355
Query: 1339 ALYEHLTAKNTKLDD 1353
+ E L K+ +L +
Sbjct: 1356 TIKEALEVKHDQLKE 1370
Score = 36.6 bits (83), Expect = 0.17
Identities = 170/903 (18%), Positives = 354/903 (39%), Gaps = 109/903 (12%)
Query: 524 VLSFLKSNTLPISLQSIRSSLL-----LGFRRSMNINLWSEITELLYKDGRYCQEPRGPT 578
+LS LKS LP ++ +R + L S L+SE+ ++K+ R +G
Sbjct: 745 LLSELKS--LPSEVERLRKEIQDKSEELHIITSEKDKLFSEV---VHKESRV----QGLL 795
Query: 579 EAVGYFLYNLIDSMSDSEVQAKE----EHLRQYFHQLEKMNVKIPENIYRGIRNLLE--- 631
E +G +L + S+ + +E + L F Q KM ++ E + + I NL +
Sbjct: 796 EEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQ 855
Query: 632 -------------SYHVPELIKDAHLLVESKNLDFQKTVQLTSSELESTLETLKAENQPI 678
SY EL + + E N Q QL + + STL+T++ E I
Sbjct: 856 KFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD--STLQTVEREKTLI 913
Query: 679 RDVLKQL---ILVLCSEENMQKALELKAKYESDMVTGGYAALINLCC-RHDKVEDAL-NL 733
+ L+Q + L E++ K L+ + E D + +N+ +++ +AL +L
Sbjct: 914 TEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESL 973
Query: 734 KEEFDRLDSSAVLDTGKYVGLVRVLAKHGKLQDAINILKEMKEKDVLIKDTTALSFFHML 793
K+ + +++ + + + + G+ +D E ++K V I L
Sbjct: 974 KQHQETINTLKSKISEEVSRNLHMEENTGETKD------EFQQKMVGIDKKQDLE---AK 1024
Query: 794 NGAALRGEIETVKQLHEAIVTLGLAEPSTNISFPLVTVHLEKGDLSTALEVAIDC-YEKY 852
N L +++ + + + L + + L +V EK L T L+ I+ E
Sbjct: 1025 NTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQ 1084
Query: 853 KVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMVMLYDLFFAF---LQTGNYKEAKK 909
+ L + D L K + +++ + + +++GE+ D L+ + + +K
Sbjct: 1085 EELRLLGDEL-----KKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEK 1139
Query: 910 IIETPGIRARSARLQWFCDRCVANNQVETLE---KLVELTQKLFECDRDQMYYNLLKLYK 966
+ ++ + +Q N++E L+ K ELT + E +R ++ L + Y+
Sbjct: 1140 QQQLLNVQEEMSEMQ------KKINEIENLKNELKNKELTLEHMETERLELAQKLNENYE 1193
Query: 967 INGDWQRADAVWNKIQEENVIPREKTLRLLAEILREGNQ-EVPFDVPELWYEDEKHSLNS 1025
+ V ++Q+ R+ + EI G Q + + + ++ + +++
Sbjct: 1194 EVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDE 1253
Query: 1026 SSASTTEPDFQKDILIACRLNQKKGAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQ 1085
S +E Q + K +I + +EQ ++ N + S + + + T+
Sbjct: 1254 LRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTE 1313
Query: 1086 AMEVK---AFAETHIKGFTLNDA---ANSRLIITQVRRDYLKEAVTTLKTVLDQQQTPSR 1139
K A ++ LN+ + + RD LK L+ DQ + R
Sbjct: 1314 QSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIR 1373
Query: 1140 LAVTRVI-------QALAMKG-DVENIEVVQKM---------LNGLE-DSIGLSKMVFIN 1181
+ ++ Q+L MK D E ++V +M L +E + +GLSK + +
Sbjct: 1374 ETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQES 1433
Query: 1182 NIALAQIKNNNIDAAIENIENMLTSENKVIEPQYFGLAYLFRKVIEE---------QLEP 1232
+ + + D ++ ++ +L SE+ ++ + + EE + E
Sbjct: 1434 HDEMKSVAKEKDD--LQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEE 1491
Query: 1233 AVEKISI-MAERLANQFAIYKP---VTDFFLQLVDAGKVDDARALLQRCGAIAEQTPILL 1288
+ ++ + ++E+ I K + D + + + +++ + E+ L
Sbjct: 1492 TINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELK 1551
Query: 1289 LFLLRNSRKQGKASTVKS-VLELIPELNEKEEAYNSLMKSYVSEKDVTSAKALYEHLTAK 1347
F K +++S +LEL L E +E ++K K V A + +
Sbjct: 1552 QFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKE 1611
Query: 1348 NTK 1350
NTK
Sbjct: 1612 NTK 1614
Score = 33.1 bits (74), Expect = 1.9
Identities = 162/812 (19%), Positives = 321/812 (39%), Gaps = 128/812 (15%)
Query: 596 EVQAKEEHLRQYFHQLEKMNVKIPE--NIYRGIRN--LLESYHVPELIKDAHLLVESKNL 651
++Q K++ L ++ +M KI E N+ ++N L + E ++ A L E N
Sbjct: 1135 QLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNE--NY 1192
Query: 652 DFQKTVQLTSSELESTLETLKAENQPIRDVLKQLILV-LCSEENMQKA-LELKAKYES-- 707
+ K++ L+ ++ + E +R ++++ L ++E ++ A + LK E+
Sbjct: 1193 EEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETID 1252
Query: 708 ---DMVTGGYAALIN---LCCRHDKVEDAL-----------NLKEEFDRLDSSAVLD--- 747
V+ A +IN L H K+++ + N+KE + ++ L+
Sbjct: 1253 ELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLT 1312
Query: 748 ----TGKYVGLVRV----LAKHGKLQDAINILKEM-KEKDVLIKDTTALSFFHMLNGAAL 798
T L R+ L + K Q++ +K + KE+D L AL H +
Sbjct: 1313 EQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHI 1372
Query: 799 RGEIETVKQLHEAIV----TLGLAEPSTNISFPLVTVHLEKGDLSTALEVAIDCYEKYKV 854
R ET+ ++ E+ +L + E + + + K S L + I+ K
Sbjct: 1373 R---ETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKR 1429
Query: 855 LPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMVM-LYDLFFAFLQTGNYKEAKKIIET 913
L HD + K V K + DL Q+ + + E ++ + ++ L+T +E K+
Sbjct: 1430 LQESHDEM-KSVAKEKDDL-QRLQEVLQSESDQLKENIKEIVAKHLET---EEELKVAH- 1483
Query: 914 PGIRARSARLQWFCDRCVANNQVETLEKL-VELTQKLFECDRDQMYYNLLKLYKINGDWQ 972
C Q ET+ +L V L++K E Q +L IN
Sbjct: 1484 ----------------CCLKEQEETINELRVNLSEKETEISTIQK-----QLEAIN---- 1518
Query: 973 RADAVWNKIQEENVIPREKTLRLLAEILREGNQEVPFDVPELWYEDEKHSLNSSSASTTE 1032
D + NKIQE + ++ ++E+ + N+ F + S+ S T
Sbjct: 1519 --DKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTN 1576
Query: 1033 --PDFQKDILIACRLNQKKGAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEVK 1090
+ Q++I I + ++ L + + N + +K ++Y Q +++
Sbjct: 1577 RLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEY--QFLKMT 1634
Query: 1091 AFAET--------HIKG------FTLNDAANSRLIITQV-------------RRDYLKEA 1123
A ET H+K L + + +TQ+ RD L+
Sbjct: 1635 AVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSV 1694
Query: 1124 VTTLKTVLDQQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVFINNI 1183
TLK DQ + R +TR ++ E +++V L +++I K+ I +
Sbjct: 1695 EETLKVERDQLKENLRETITRDLE------KQEELKIVHMHLKEHQETI--DKLRGIVSE 1746
Query: 1184 ALAQIKNNNIDAAIENIENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVEKISIMAER 1243
+I N D +E+ + L +++ I+ + +A++ K +E ++ +S ++
Sbjct: 1747 KTNEISNMQKD--LEHSNDALKAQDLKIQEE-LRIAHMHLKEQQETIDKLRGIVSEKTDK 1803
Query: 1244 LANQFAIYKPVTDFFLQLVDAGKVDDARALLQRCGAIAEQTPILLLFLLRNSRKQGKAST 1303
L+N + + + K ++ + + + Q + + L+ K S
Sbjct: 1804 LSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKD--QSL 1861
Query: 1304 VKSVLELIPELNEKEEAYNSL--MKSYVSEKD 1333
S LE I LN ++ + +L MKS + E+D
Sbjct: 1862 TLSKLE-IENLNLAQKLHENLEEMKSVMKERD 1892
Score = 30.8 bits (68), Expect = 9.5
Identities = 31/120 (25%), Positives = 54/120 (45%), Gaps = 26/120 (21%)
Query: 586 YNLIDSMSDSEVQAKE---EHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDA 642
Y + + +E Q K EHL++ F + +K+N+ ENI L + H
Sbjct: 1628 YQFLKMTAVNETQEKMCEIEHLKEQF-ETQKLNL---ENIETENIRLTQILH-------- 1675
Query: 643 HLLVESKNLDFQKTVQLTSSELESTLETLKAENQPIRDVLKQLILVLCSEENMQKALELK 702
+NL+ ++V +L S ETLK E +++ L++ I +++K ELK
Sbjct: 1676 ------ENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETI-----TRDLEKQEELK 1724
>gi|22749429 coiled-coil domain containing 89 [Homo sapiens]
Length = 374
Score = 35.8 bits (81), Expect = 0.30
Identities = 65/234 (27%), Positives = 106/234 (45%), Gaps = 46/234 (19%)
Query: 657 VQLTSSELESTL----ETLKAENQPIRDVLKQLILVLCSEENMQKALELKAKYESDMVTG 712
++L ++ELE + E LKA+ + R + ++ + + + E M L K +Y+S+
Sbjct: 94 LELLNAELEEKMMQEAEKLKAQGEYSRKLEERFMTLAANHELM---LRFKDEYKSE---- 146
Query: 713 GYAALINLCCRHDKVEDALNLKEEFDRLDSSAVLDT-GKYVGL-VRVLAKHGKL------ 764
N+ R E+ L+ E L S A+ D K + L VR A G+L
Sbjct: 147 ------NIKLR----EENEKLRLENSSLFSQALKDEEAKVLQLTVRCEALTGELETLKER 196
Query: 765 --QDAINILKEMKEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLH-EAIVTLGLAEP- 820
QDA KE L++ + + H LR +++T+KQ H +A+ + AE
Sbjct: 197 CAQDACQAQAREKE---LLELQSQQACTHTKETEQLRSQLQTLKQQHQQAVEQIAKAEET 253
Query: 821 ----STNISFPLVTVHLEKGDLSTALEVAIDCYEKYKVLPRIHDVLCKLVEKGE 870
S + L TV EK +L L+++I E+ KVL +C+L EK E
Sbjct: 254 HSSLSQELQARLQTVTREKEEL---LQLSI---ERGKVLQNKQAEICQLEEKLE 301
>gi|222136607 tetratricopeptide repeat domain 26 isoform 3 [Homo
sapiens]
Length = 523
Score = 34.3 bits (77), Expect = 0.86
Identities = 30/138 (21%), Positives = 66/138 (47%), Gaps = 11/138 (7%)
Query: 850 EKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMVMLYDLFFAFLQTGNYKEAKK 909
+K + +P++ ++L K G L+++ + +E + +L + G YK+A
Sbjct: 22 KKGRKIPKLEELLSKRDFTGAITLLEEYENATKEENCNSEVWVNLACTYFFLGMYKQA-- 79
Query: 910 IIETPGIRARSARLQWFCDRCVAN--NQVETLEKLVELTQKLFECDRDQMYYNLLKLYKI 967
E G +A +RLQ +R + + ++ +KL+ Q L + DQ+ +L ++ +
Sbjct: 80 --EAAGFKASKSRLQ---NRLLFHLAHKFNDEKKLMSFHQNLQDVTEDQL--SLASIHYM 132
Query: 968 NGDWQRADAVWNKIQEEN 985
+Q A ++ +I +N
Sbjct: 133 RSHYQEAIDIYKRILLDN 150
>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
b [Homo sapiens]
Length = 882
Score = 33.9 bits (76), Expect = 1.1
Identities = 40/188 (21%), Positives = 81/188 (43%), Gaps = 21/188 (11%)
Query: 597 VQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKNLDFQKT 656
++ K E L++ K + K+ E +R E + +K+ +E +N + +
Sbjct: 471 LEDKREQLKK-----SKEHEKLMEGELEALRQ--EFKKKDKTLKENSRKLEEENENLRAE 523
Query: 657 VQLTSSELESTLETLKAENQPIRDVLKQLIL----VLCSEENMQKALELKAKYESDMVT- 711
+Q S++LES+L Q I+D+ K++ L ++ + + KAL+ + Y +T
Sbjct: 524 LQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITK 583
Query: 712 GGYAALI--NLCCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVGLVRVLAKHGKLQDAIN 769
Y AL + C+ D L + ++L+ L + K +L++ I
Sbjct: 584 EAYDALSRKSAACQDD-------LTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEII 636
Query: 770 ILKEMKEK 777
+E +K
Sbjct: 637 AYEERMKK 644
>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform
a [Homo sapiens]
Length = 1007
Score = 33.9 bits (76), Expect = 1.1
Identities = 40/188 (21%), Positives = 81/188 (43%), Gaps = 21/188 (11%)
Query: 597 VQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKNLDFQKT 656
++ K E L++ K + K+ E +R E + +K+ +E +N + +
Sbjct: 616 LEDKREQLKK-----SKEHEKLMEGELEALRQ--EFKKKDKTLKENSRKLEEENENLRAE 668
Query: 657 VQLTSSELESTLETLKAENQPIRDVLKQLIL----VLCSEENMQKALELKAKYESDMVT- 711
+Q S++LES+L Q I+D+ K++ L ++ + + KAL+ + Y +T
Sbjct: 669 LQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITK 728
Query: 712 GGYAALI--NLCCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVGLVRVLAKHGKLQDAIN 769
Y AL + C+ D L + ++L+ L + K +L++ I
Sbjct: 729 EAYDALSRKSAACQDD-------LTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEII 781
Query: 770 ILKEMKEK 777
+E +K
Sbjct: 782 AYEERMKK 789
>gi|51093830 bicaudal D homolog 1 isoform 2 [Homo sapiens]
Length = 835
Score = 33.9 bits (76), Expect = 1.1
Identities = 25/102 (24%), Positives = 51/102 (50%), Gaps = 3/102 (2%)
Query: 596 EVQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIK---DAHLLVESKNLD 652
E + +E L Q + +LE+ N+ + + + +N +E + IK + +L+ S+ D
Sbjct: 160 EYKFREARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLED 219
Query: 653 FQKTVQLTSSELESTLETLKAENQPIRDVLKQLILVLCSEEN 694
+ ++ +LE LETLK E + ++ K+L + +N
Sbjct: 220 AIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDN 261
>gi|51039802 bicaudal D homolog 1 isoform 1 [Homo sapiens]
Length = 975
Score = 33.9 bits (76), Expect = 1.1
Identities = 25/102 (24%), Positives = 51/102 (50%), Gaps = 3/102 (2%)
Query: 596 EVQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIK---DAHLLVESKNLD 652
E + +E L Q + +LE+ N+ + + + +N +E + IK + +L+ S+ D
Sbjct: 160 EYKFREARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLED 219
Query: 653 FQKTVQLTSSELESTLETLKAENQPIRDVLKQLILVLCSEEN 694
+ ++ +LE LETLK E + ++ K+L + +N
Sbjct: 220 AIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDN 261
>gi|98986331 pentatricopeptide repeat domain 2 [Homo sapiens]
Length = 388
Score = 33.9 bits (76), Expect = 1.1
Identities = 40/153 (26%), Positives = 69/153 (45%), Gaps = 17/153 (11%)
Query: 652 DFQKTVQLTSSELESTLET----LKAENQPIRDVLKQLILVLC----SEENMQKALELKA 703
+FQ+ + L T ET LK + + +LK ++ L S ++++ A +
Sbjct: 57 EFQQKKVAVACNLSGTKETYFRNLKKKLTQNKLILKGELITLLHLCESRDHVELAKNVIY 116
Query: 704 KYESD---MVTGGYA---ALINLCCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVGLVRV 757
+Y ++ G Y + LC D E A+ L + D+ D+ + L+ +
Sbjct: 117 RYHAENKNFTLGEYKFGPLFVRLCYELDLEESAVELMK--DQHLRGFFSDSTSFNILMDM 174
Query: 758 LAKHGKLQDAINILKEMKEKDV-LIKDTTALSF 789
L GK + A+ +L EMK +DV KDT L+F
Sbjct: 175 LFIKGKYKSALQVLIEMKNQDVKFTKDTYVLAF 207
>gi|51479166 bicaudal D homolog 2 isoform 1 [Homo sapiens]
Length = 855
Score = 33.9 bits (76), Expect = 1.1
Identities = 24/93 (25%), Positives = 44/93 (47%), Gaps = 3/93 (3%)
Query: 596 EVQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKNLDFQK 655
E + +E L Q + +LE+ N+ + + + +N +E + IK E N +
Sbjct: 169 EYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLED 228
Query: 656 TVQL---TSSELESTLETLKAENQPIRDVLKQL 685
++L + +LE LETLK E + + K+L
Sbjct: 229 AIRLKEISERQLEEALETLKTEREQKNSLRKEL 261
>gi|21735417 bicaudal D homolog 2 isoform 2 [Homo sapiens]
Length = 824
Score = 33.9 bits (76), Expect = 1.1
Identities = 24/93 (25%), Positives = 44/93 (47%), Gaps = 3/93 (3%)
Query: 596 EVQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKNLDFQK 655
E + +E L Q + +LE+ N+ + + + +N +E + IK E N +
Sbjct: 169 EYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLED 228
Query: 656 TVQL---TSSELESTLETLKAENQPIRDVLKQL 685
++L + +LE LETLK E + + K+L
Sbjct: 229 AIRLKEISERQLEEALETLKTEREQKNSLRKEL 261
>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
Length = 872
Score = 33.9 bits (76), Expect = 1.1
Identities = 33/124 (26%), Positives = 54/124 (43%), Gaps = 15/124 (12%)
Query: 591 SMSDSEVQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKN 650
S E+Q ++ + F + EK+ ++ + I+ ++S IK V+
Sbjct: 198 SQFQQEIQQRQNEASREFRKKEKLEKELKQ-----IQADMDSRQTE--IKALQQYVQKSK 250
Query: 651 LDFQKTVQ------LTSSELESTLETLKAENQPIRDVLKQLILVL--CSEENMQKALELK 702
+ QK Q + + LE + N ++ +Q LV S+EN QKALELK
Sbjct: 251 EELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELK 310
Query: 703 AKYE 706
AK E
Sbjct: 311 AKEE 314
>gi|190194355 p90 autoantigen [Homo sapiens]
Length = 905
Score = 33.1 bits (74), Expect = 1.9
Identities = 54/252 (21%), Positives = 104/252 (41%), Gaps = 36/252 (14%)
Query: 571 CQEPRGPTEAVGYFLYNLIDSMSDSEVQAKEEHLRQYF--HQLEKMNVKIP-ENIYRGIR 627
CQ + TEA + SM EV+ K E L Q+E + E++++ R
Sbjct: 663 CQRTQAETEA------RTLASML-REVERKNEELSVLLKAQQVESERAQSDIEHLFQHNR 715
Query: 628 NLLESYHVPELIKDAHLLVESKNLDFQKT---VQLTSSELESTLETLKAENQPIRDVLKQ 684
L E++ +++ + +N +K +Q+T L +ET+K N+ +++ ++
Sbjct: 716 KLESVAEEHEILTKSYMELLQRNESTEKKNKDLQITCDSLNKQIETVKKLNESLKEQNEK 775
Query: 685 LILVLCSEENMQKA--------------LELKAKYESDMVTGGYAALINLCCRHDKVEDA 730
I L +E +K L K K + + + R DK E
Sbjct: 776 SIAQLIEKEEQRKEVQNQLVDREHKLANLHQKTKVQEEKIKTLQKE------REDKEETI 829
Query: 731 LNLKEEFDRLDSSAVLDTGKYVGL-VRVLAKHGKLQDAINILKEMKEKDVLIKDTTALSF 789
L++E R + + K L V+ G+L++ +++K +E+ L K + ++
Sbjct: 830 DILRKELSRTEQIRKELSIKASSLEVQKAQLEGRLEEKESLVKLQQEE--LNKHSHMIAM 887
Query: 790 FHMLNGAALRGE 801
H L+G + E
Sbjct: 888 IHSLSGGKINPE 899
>gi|118918407 spectrin repeat containing, nuclear envelope 2 isoform 5
[Homo sapiens]
Length = 6907
Score = 33.1 bits (74), Expect = 1.9
Identities = 44/171 (25%), Positives = 76/171 (44%), Gaps = 24/171 (14%)
Query: 615 NVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKNLDFQKTVQLTSS------ELESTL 668
++K E++ R I L +S+ KD + FQ TV+ EL+S L
Sbjct: 5773 DLKTKESVGRRISQLQDSW------KDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRL 5826
Query: 669 ETLKAENQPIRDVLKQLILVLCSEENMQKALELKAKYESDMVTGGYAALINLCCRHDKVE 728
+ LKA+++ D L +L L +E+ + K LE + + +L RH VE
Sbjct: 5827 QVLKAQSE---DPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLT-RHVLVE 5882
Query: 729 DALNLKEEFDRLDSSAVLDTGKYVGL-VRVLAKHGKLQDAINILKEMKEKD 778
D + LKE+ + L ++ L +RV + +++D +N EK+
Sbjct: 5883 DVMVLKEQIEHLHR-------QWEDLCLRVAIRKQEIEDRLNTWVVFNEKN 5926
>gi|118918403 spectrin repeat containing, nuclear envelope 2 isoform 1
[Homo sapiens]
Length = 6885
Score = 33.1 bits (74), Expect = 1.9
Identities = 44/171 (25%), Positives = 76/171 (44%), Gaps = 24/171 (14%)
Query: 615 NVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKNLDFQKTVQLTSS------ELESTL 668
++K E++ R I L +S+ KD + FQ TV+ EL+S L
Sbjct: 5773 DLKTKESVGRRISQLQDSW------KDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRL 5826
Query: 669 ETLKAENQPIRDVLKQLILVLCSEENMQKALELKAKYESDMVTGGYAALINLCCRHDKVE 728
+ LKA+++ D L +L L +E+ + K LE + + +L RH VE
Sbjct: 5827 QVLKAQSE---DPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLT-RHVLVE 5882
Query: 729 DALNLKEEFDRLDSSAVLDTGKYVGL-VRVLAKHGKLQDAINILKEMKEKD 778
D + LKE+ + L ++ L +RV + +++D +N EK+
Sbjct: 5883 DVMVLKEQIEHLHR-------QWEDLCLRVAIRKQEIEDRLNTWVVFNEKN 5926
>gi|9506557 Down syndrome critical region protein 6 [Homo sapiens]
Length = 190
Score = 33.1 bits (74), Expect = 1.9
Identities = 26/85 (30%), Positives = 37/85 (43%), Gaps = 5/85 (5%)
Query: 373 GSFFLQHCVTMNTPVEKLTDYCKKLKEVQMHSFPLQFTLHCALLANKTDLAKALMKAVKE 432
G+F QH V + P+ K +Y + E + SFP+Q T+ + A E
Sbjct: 71 GAFGFQHPVRVYLPMSKRQEYLRSSGEQVLASFPVQATID---FYDDESTESASEAEEPE 127
Query: 433 EGFPIRPHYFWPLLVGRRKEKNVQG 457
EG P P + P VG R+E G
Sbjct: 128 EGPP--PLHLLPQEVGGRQENGPGG 150
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 32.7 bits (73), Expect = 2.5
Identities = 37/175 (21%), Positives = 71/175 (40%), Gaps = 24/175 (13%)
Query: 714 YAALINLCCRH-DKVEDALNLKEEFDRLDSSAVLD----------TGKYVGLVRVLAKHG 762
Y + LC H D + + N+K E ++ + L + L VL + G
Sbjct: 306 YNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQG 365
Query: 763 KLQDAINILKEMKEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTLGLAEPST 822
KLQ+A+ KE + I T A ++ +M N +++ Q + + + A
Sbjct: 366 KLQEALMHYKEA----IRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADA 421
Query: 823 NISFPLVTVHLEKGDL-------STALEVAIDCYEKYKVLPRIHDVLCKLVEKGE 870
+ + L ++H + G++ TAL++ D + Y L ++C + E
Sbjct: 422 HSN--LASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDE 474
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 32.7 bits (73), Expect = 2.5
Identities = 37/175 (21%), Positives = 71/175 (40%), Gaps = 24/175 (13%)
Query: 714 YAALINLCCRH-DKVEDALNLKEEFDRLDSSAVLD----------TGKYVGLVRVLAKHG 762
Y + LC H D + + N+K E ++ + L + L VL + G
Sbjct: 316 YNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQG 375
Query: 763 KLQDAINILKEMKEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTLGLAEPST 822
KLQ+A+ KE + I T A ++ +M N +++ Q + + + A
Sbjct: 376 KLQEALMHYKEA----IRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADA 431
Query: 823 NISFPLVTVHLEKGDL-------STALEVAIDCYEKYKVLPRIHDVLCKLVEKGE 870
+ + L ++H + G++ TAL++ D + Y L ++C + E
Sbjct: 432 HSN--LASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDE 484
>gi|110347443 TATA element modulatory factor 1 [Homo sapiens]
Length = 1093
Score = 32.3 bits (72), Expect = 3.3
Identities = 97/434 (22%), Positives = 170/434 (39%), Gaps = 56/434 (12%)
Query: 647 ESKNLDFQKTVQLTSSELESTLETLKAENQPIRDVLKQ---LILVLCSEENMQKALELKA 703
E KN+ + +L SSE T + LK +++ IR ++++ L N+ K L K
Sbjct: 527 EIKNIKEELATRLNSSE---TADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKD 583
Query: 704 KYESDMVTGGYAALINLCCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVGLVRVLAKHGK 763
K +MV A +N KV++ L+EE L VLD G V +H +
Sbjct: 584 KENENMV-----AKLN-----KKVKE---LEEELQHL--KQVLD-----GKEEVEKQHRE 623
Query: 764 LQDAINILKEMKEKDV--LIKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTLGLAEPS 821
+N + E +EKD+ L D L + AAL + + LH+A A+ S
Sbjct: 624 NIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELTDLHKA----NAAKDS 679
Query: 822 TNISFPLVTVHLEKGDLSTALEVAIDCYEKYKVLPRIHDVLCKLVEKGETDLIQKAMDFV 881
L K +LS ALE A + + + I +L + + D++
Sbjct: 680 EAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYL 739
Query: 882 SQEQGEMVMLYDLFFAFLQTGNYKEAKKIIETPGIRARSARLQWFCDRCVANNQVETLEK 941
E GE+ LQ + +++ ++ R Q + +Q + EK
Sbjct: 740 RHEIGELQQR-------LQEAENRN-QELSQSVSSTTRPLLRQIENLQATLGSQTSSWEK 791
Query: 942 LVE-LTQKLFECDRDQMYYNLLKLYKINGDWQRADAVWNKIQ-----EENVIPREKTLRL 995
L + L+ +L E LL + + NKIQ +N + R++ R
Sbjct: 792 LEKNLSDRLGESQ------TLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRF 845
Query: 996 LAEILREGNQEVPFDVPELWYEDEKHSLNSSSASTTEPDFQKDILIACRLNQKKGAYDIF 1055
A++ E N+ + Y+ E +L T E ++ L+ +L ++ +
Sbjct: 846 QAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMER----MK 901
Query: 1056 LNAKEQNIVFNAET 1069
+ + + +F ET
Sbjct: 902 VEQERKKAIFTQET 915
>gi|223029422 SKI-like isoform 3 [Homo sapiens]
Length = 664
Score = 32.0 bits (71), Expect = 4.3
Identities = 27/110 (24%), Positives = 53/110 (48%), Gaps = 11/110 (10%)
Query: 594 DSEVQAKEEHLRQYFHQLEKMNVKI--PENIYRGIRNLLESYHVPELIKDAHLLVESKNL 651
D + + EE +R Y Q EK+N+ + + + ++ L S + EL + E +NL
Sbjct: 505 DDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTE------EQQNL 558
Query: 652 DFQKTVQLTSSELESTLETLKAENQPIRDVLKQLILVLCS-EENMQKALE 700
QK ++ +E +E E + + L+Q++ C+ + N++K E
Sbjct: 559 --QKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKE 606
>gi|223029420 SKI-like isoform 2 [Homo sapiens]
Length = 638
Score = 32.0 bits (71), Expect = 4.3
Identities = 27/110 (24%), Positives = 53/110 (48%), Gaps = 11/110 (10%)
Query: 594 DSEVQAKEEHLRQYFHQLEKMNVKI--PENIYRGIRNLLESYHVPELIKDAHLLVESKNL 651
D + + EE +R Y Q EK+N+ + + + ++ L S + EL + E +NL
Sbjct: 479 DDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTE------EQQNL 532
Query: 652 DFQKTVQLTSSELESTLETLKAENQPIRDVLKQLILVLCS-EENMQKALE 700
QK ++ +E +E E + + L+Q++ C+ + N++K E
Sbjct: 533 --QKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKE 580
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,595,373
Number of Sequences: 37866
Number of extensions: 2059535
Number of successful extensions: 6304
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 53
Number of HSP's that attempted gapping in prelim test: 6180
Number of HSP's gapped (non-prelim): 182
length of query: 1394
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1279
effective length of database: 13,892,928
effective search space: 17769054912
effective search space used: 17769054912
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.