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Search of human proteins with 31563526
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31563526 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 3 [Homo sapiens]
(644 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31563526 solute carrier family 24 (sodium/potassium/calcium e... 1298 0.0
gi|24111228 solute carrier family 24 member 4 isoform 1 precurso... 704 0.0
gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo sa... 704 0.0
gi|29788985 solute carrier family 24 member 4 isoform 2 precurso... 700 0.0
gi|9966787 solute carrier family 24 (sodium/potassium/calcium ex... 370 e-102
gi|4759128 solute carrier family 24 (sodium/potassium/calcium ex... 209 5e-54
gi|45504369 solute carrier family 24, member 5 [Homo sapiens] 196 7e-50
gi|39995086 solute carrier family 24 member 6 [Homo sapiens] 81 3e-15
gi|10863913 solute carrier family 8 (sodium/calcium exchanger), ... 68 2e-11
gi|163914373 solute carrier family 8 (sodium/calcium exchanger),... 68 2e-11
gi|163914371 solute carrier family 8 (sodium/calcium exchanger),... 68 2e-11
gi|163914369 solute carrier family 8 (sodium/calcium exchanger),... 68 2e-11
gi|57163987 solute carrier family 8 member 2 [Homo sapiens] 66 9e-11
gi|17865805 solute carrier family 8 (sodium/calcium exchanger), ... 65 3e-10
gi|33946308 solute carrier family 8 (sodium/calcium exchanger), ... 65 3e-10
gi|33946304 solute carrier family 8 (sodium/calcium exchanger), ... 65 3e-10
gi|194354001 solute carrier family 8 (sodium/calcium exchanger),... 65 3e-10
gi|15147254 solute carrier family 8 (sodium/calcium exchanger), ... 65 3e-10
gi|33946311 solute carrier family 8 (sodium/calcium exchanger), ... 65 3e-10
gi|17975763 myelin transcription factor 1 [Homo sapiens] 41 0.004
gi|4503257 death-domain associated protein isoform a [Homo sapiens] 40 0.005
gi|215422388 death-domain associated protein isoform a [Homo sap... 40 0.005
gi|215422366 death-domain associated protein isoform b [Homo sap... 40 0.005
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens] 40 0.005
gi|100816397 MYST histone acetyltransferase (monocytic leukemia)... 40 0.005
gi|140972063 protein phosphatase 1, regulatory subunit 9B [Homo ... 40 0.007
gi|86262149 zinc finger and BTB domain containing 7C [Homo sapiens] 40 0.007
gi|115529449 upstream binding transcription factor, RNA polymera... 40 0.009
gi|115529451 upstream binding transcription factor, RNA polymera... 40 0.009
gi|7657671 upstream binding transcription factor, RNA polymerase... 40 0.009
>gi|31563526 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 3 [Homo sapiens]
Length = 644
Score = 1298 bits (3359), Expect = 0.0
Identities = 644/644 (100%), Positives = 644/644 (100%)
Query: 1 MRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRK 60
MRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRK
Sbjct: 1 MRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRK 60
Query: 61 WMMARKLMQVNDTLTSEDAGLRNSKNCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYM 120
WMMARKLMQVNDTLTSEDAGLRNSKNCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYM
Sbjct: 61 WMMARKLMQVNDTLTSEDAGLRNSKNCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYM 120
Query: 121 FYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGV 180
FYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGV
Sbjct: 121 FYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGV 180
Query: 181 GTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWE 240
GTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWE
Sbjct: 181 GTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWE 240
Query: 241 SLVLVLMYLIYIVIMKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKK 300
SLVLVLMYLIYIVIMKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKK
Sbjct: 241 SLVLVLMYLIYIVIMKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKK 300
Query: 301 ANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLIN 360
ANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLIN
Sbjct: 301 ANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLIN 360
Query: 361 SRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNEN 420
SRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNEN
Sbjct: 361 SRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNEN 420
Query: 421 DEEEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTF 480
DEEEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTF
Sbjct: 421 DEEEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTF 480
Query: 481 ASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDM 540
ASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDM
Sbjct: 481 ASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDM 540
Query: 541 AVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVH 600
AVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVH
Sbjct: 541 AVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVH 600
Query: 601 LNKWQLDKKLGCGCLLLYGVFLCFSIMTEFNVFTFVNLPMCGDH 644
LNKWQLDKKLGCGCLLLYGVFLCFSIMTEFNVFTFVNLPMCGDH
Sbjct: 601 LNKWQLDKKLGCGCLLLYGVFLCFSIMTEFNVFTFVNLPMCGDH 644
>gi|24111228 solute carrier family 24 member 4 isoform 1 precursor
[Homo sapiens]
Length = 605
Score = 704 bits (1818), Expect = 0.0
Identities = 359/577 (62%), Positives = 435/577 (75%), Gaps = 25/577 (4%)
Query: 71 NDTLTSEDAGLRNSKNCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDD 130
N L + G + +KNCT+PA+HEFP D+F+N++R+ GAV+LH+L A+YMFYALAIVCDD
Sbjct: 44 NRKLMAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDD 103
Query: 131 FFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFN 190
FFVPSLEKICERLHLSEDVAGATFMAAGSS PELF SVIGVFIT GDVGVGTIVGSAVFN
Sbjct: 104 FFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFN 163
Query: 191 ILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLI 250
ILCIIGVCGLFAGQVV L+ W + RDS+YYT+SVI LIVFIYDE++ WWE LVL+++Y+
Sbjct: 164 ILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVF 223
Query: 251 YIVIMKYNACIHQCFERRTKGA--GNMVNG-LANNAEIDDSSNCDATVVLL---KKANFH 304
YI+IMKYN + F + K GN VN L + D S D +V LL K+ +
Sbjct: 224 YILIMKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQY 283
Query: 305 RKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLINSRAY 364
K V+MVDE++S+ P + +F EAGLRIMIT+ F P+TRL MASR++INERQRLINS
Sbjct: 284 GKNPVVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINS--- 340
Query: 365 TNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNENDEEE 424
NG S ++ +ENG P P+ + +N+ +
Sbjct: 341 ANGVSSKPLQNGRHENIENGNVPVENPE----------------DPQQNQEQQPPPQPPP 384
Query: 425 EEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFASST 484
E E + +PF P + + VKW FTWPL F+L T+PNC+KPRWEK+FMVTF ++T
Sbjct: 385 PEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITAT 444
Query: 485 LWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSN 544
LWIA FSY+MVW+VTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG+GDMAVSN
Sbjct: 445 LWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSN 504
Query: 545 SIGSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKW 604
+IGSNVFDIL+GLG+PW LQT+ V+YGS +++NSRGL+YSV LLL SV +TV G+HLNKW
Sbjct: 505 TIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKW 564
Query: 605 QLDKKLGCGCLLLYGVFLCFSIMTEFNVFTFVNLPMC 641
+LD+KLG L+LY +FLCFSIM EFNVFTFVNLPMC
Sbjct: 565 RLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPMC 601
>gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo
sapiens]
Length = 558
Score = 704 bits (1817), Expect = 0.0
Identities = 357/568 (62%), Positives = 432/568 (76%), Gaps = 25/568 (4%)
Query: 80 GLRNSKNCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDDFFVPSLEKI 139
G + +KNCT+PA+HEFP D+F+N++R+ GAV+LH+L A+YMFYALAIVCDDFFVPSLEKI
Sbjct: 6 GTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKI 65
Query: 140 CERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCG 199
CERLHLSEDVAGATFMAAGSS PELF SVIGVFIT GDVGVGTIVGSAVFNILCIIGVCG
Sbjct: 66 CERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCG 125
Query: 200 LFAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVIMKYNA 259
LFAGQVV L+ W + RDS+YYT+SVI LIVFIYDE++ WWE LVL+++Y+ YI+IMKYN
Sbjct: 126 LFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNV 185
Query: 260 CIHQCFERRTKGA--GNMVNG-LANNAEIDDSSNCDATVVLL---KKANFHRKASVIMVD 313
+ F + K GN VN L + D S D +V LL K+ + K V+MVD
Sbjct: 186 KMQAFFTVKQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNPVVMVD 245
Query: 314 ELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLINSRAYTNGESEVAI 373
E++S+ P + +F EAGLRIMIT+ F P+TRL MASR++INERQRLINS NG S +
Sbjct: 246 EIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINS---ANGVSSKPL 302
Query: 374 KIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDEG 433
+ +ENG P P+ + +N+ + E E +
Sbjct: 303 QNGRHENIENGNVPVENPE----------------DPQQNQEQQPPPQPPPPEPEPVEAD 346
Query: 434 PYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFASSTLWIAAFSYM 493
+PF P + + VKW FTWPL F+L T+PNC+KPRWEK+FMVTF ++TLWIA FSY+
Sbjct: 347 FLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYI 406
Query: 494 MVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDI 553
MVW+VTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG+GDMAVSN+IGSNVFDI
Sbjct: 407 MVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDI 466
Query: 554 LIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCG 613
L+GLG+PW LQT+ V+YGS +++NSRGL+YSV LLL SV +TV G+HLNKW+LD+KLG
Sbjct: 467 LVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVY 526
Query: 614 CLLLYGVFLCFSIMTEFNVFTFVNLPMC 641
L+LY +FLCFSIM EFNVFTFVNLPMC
Sbjct: 527 VLVLYAIFLCFSIMIEFNVFTFVNLPMC 554
>gi|29788985 solute carrier family 24 member 4 isoform 2 precursor
[Homo sapiens]
Length = 586
Score = 700 bits (1807), Expect = 0.0
Identities = 352/571 (61%), Positives = 432/571 (75%), Gaps = 32/571 (5%)
Query: 71 NDTLTSEDAGLRNSKNCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDD 130
N L + G + +KNCT+PA+HEFP D+F+N++R+ GAV+LH+L A+YMFYALAIVCDD
Sbjct: 44 NRKLMAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDD 103
Query: 131 FFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFN 190
FFVPSLEKICERLHLSEDVAGATFMAAGSS PELF SVIGVFIT GDVGVGTIVGSAVFN
Sbjct: 104 FFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFN 163
Query: 191 ILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLI 250
ILCIIGVCGLFAGQVV L+ W + RDS+YYT+SVI LIVFIYDE++ WWE LVL+++Y+
Sbjct: 164 ILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVF 223
Query: 251 YIVIMKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKKANFHRKASVI 310
YI+IMKYN + F + K ++ NG N+E++ +K+ + K V+
Sbjct: 224 YILIMKYNVKMQAFFTVKQK---SIANGNPVNSELE----------AVKEKPQYGKNPVV 270
Query: 311 MVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLINSRAYTNGESE 370
MVDE++S+ P + +F EAGLRIMIT+ F P+TRL MASR++INERQRLINS NG S
Sbjct: 271 MVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINS---ANGVSS 327
Query: 371 VAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDD 430
++ +ENG P P+ + +N+ + E E
Sbjct: 328 KPLQNGRHENIENGNVPVENPE----------------DPQQNQEQQPPPQPPPPEPEPV 371
Query: 431 DEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFASSTLWIAAF 490
+ +PF P + + VKW FTWPL F+L T+PNC+KPRWEK+FMVTF ++TLWIA F
Sbjct: 372 EADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVF 431
Query: 491 SYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNV 550
SY+MVW+VTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQG+GDMAVSN+IGSNV
Sbjct: 432 SYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNV 491
Query: 551 FDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKL 610
FDIL+GLG+PW LQT+ V+YGS +++NSRGL+YSV LLL SV +TV G+HLNKW+LD+KL
Sbjct: 492 FDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKL 551
Query: 611 GCGCLLLYGVFLCFSIMTEFNVFTFVNLPMC 641
G L+LY +FLCFSIM EFNVFTFVNLPMC
Sbjct: 552 GVYVLVLYAIFLCFSIMIEFNVFTFVNLPMC 582
>gi|9966787 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 2 [Homo sapiens]
Length = 661
Score = 370 bits (949), Expect = e-102
Identities = 217/559 (38%), Positives = 321/559 (57%), Gaps = 19/559 (3%)
Query: 84 SKNCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDDFFVPSLEKICERL 143
S+N T+ A ++P DIF+ E+RR+GA++LHV+ IYMF ALAIVCD+FFVPSL I E+L
Sbjct: 109 SENSTDHAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKL 168
Query: 144 HLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAG 203
+S+DVAGATFMAAG SAPELFTS+IGVFI +VG+GTIVGSAVFNIL +IG+C LF+
Sbjct: 169 GISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSR 228
Query: 204 QVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVIMKYNACIHQ 263
+++ L+ W L RD +Y + +I LI+F D + WWESL+L+ Y Y+V MK+N + +
Sbjct: 229 EILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKFNVQVEK 288
Query: 264 CFERRTKGAGNMVNGLANNAEIDDSSNCDA-TVVLLKKANFHRKASVIMVDELLSAYPHQ 322
+ ++ +V A A+ S+ D L K R S SA H
Sbjct: 289 -WVKQMINRNKVVKVTAPEAQAKPSAARDKDEPTLPAKPRLQRGGS--------SASLHN 339
Query: 323 LSFSEAGLRIMITSHFPPKTRLSMASRM----LINERQRLINSRAYTNGESEVAIKIPIK 378
+ ++MI + P L ++ + E R + + ++ + +
Sbjct: 340 SLMRNSIFQLMIHTLDPLAEELGSYGKLKYYDTMTEEGRFREKASILHKIAKKKCHVD-E 398
Query: 379 HTVENGTGPSSAPDRGVNGTRRDDVV---AEAGNETENENEDNENDEEEEEDEDDDEGPY 435
+ +NG N T D + ++A +N N + + E + D++E
Sbjct: 399 NERQNGAANHVEKIELPNSTSTDVEMTPSSDASEPVQNGNLSHNIEGAEAQTADEEEDQP 458
Query: 436 TPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFASSTLWIAAFSYMMV 495
PS + V + +P+ F L+ T+P+ KP K+F +TF S WIA FSY+MV
Sbjct: 459 LSLAWPSETRKQVTFLIVFPIVFPLWITLPDVRKPSSRKFFPITFFGSITWIAVFSYLMV 518
Query: 496 WMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILI 555
W +G T+GI + IMG+T LAAGTS+PD + S+IVAR+G+GDMAVS+S+GSN+FDI +
Sbjct: 519 WWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITV 578
Query: 556 GLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCL 615
GL LPW L T+ + + ++S GL ++ LL + + + L KW+++K LG
Sbjct: 579 GLPLPWLLYTV-IHRFQPVAVSSNGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMF 637
Query: 616 LLYGVFLCFSIMTEFNVFT 634
LY VFL S++ E + T
Sbjct: 638 GLYFVFLVVSVLLEDRILT 656
>gi|4759128 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 1 [Homo sapiens]
Length = 1099
Score = 209 bits (533), Expect = 5e-54
Identities = 136/347 (39%), Positives = 198/347 (57%), Gaps = 15/347 (4%)
Query: 90 PALH---EFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDDFFVPSLEKICERLHLS 146
P LH E+P D+F+ E+RRQG VVLHV +Y+F ALAIVCD++FVP+L I ++L +S
Sbjct: 432 PDLHPKGEYPPDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFVPALGVITDKLQIS 491
Query: 147 EDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVV 206
EDVAGATFMAAG SAPELFTS+IGVFI+ +VG+GTIVGSAVFNIL +IG C LF+ +++
Sbjct: 492 EDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREIL 551
Query: 207 ALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVIMKYNACIHQCFE 266
L+ W L RD +Y L +I LI+F D ++WWESL+L+L Y Y+ MK+N I +
Sbjct: 552 NLTWWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWNKHIEVWVK 611
Query: 267 RRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKKANFHRKASV--IMVDELLSAYPHQLS 324
+ +A ++D S + + + ++K + ++ S H +
Sbjct: 612 EQLSR-----RPVAKVMALEDLSKPGDGAIAVDELQDNKKLKLPSLLTRGSSSTSLHNST 666
Query: 325 FSEAGLRIMITSHFP-PKTRLSM-ASRMLINERQRL-INSRAYTNGESEVAIKIPIKHTV 381
++M+ S P + RL+ +N+ R ++A + E E K+P TV
Sbjct: 667 IRSTIYQLMLHSLDPLREVRLAKEKEEESLNQGARAQPQAKAESKPEEEEPAKLPAV-TV 725
Query: 382 ENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDE 428
P D+ N ++D VAEA + E E+ E E E +E
Sbjct: 726 TPAPVPDIKGDQKENPGGQED-VAEAESTGEMPGEEGETAGEGETEE 771
Score = 188 bits (477), Expect = 2e-47
Identities = 97/243 (39%), Positives = 151/243 (62%), Gaps = 3/243 (1%)
Query: 394 GVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDEGPYTPF--DTPSGKLETVKWA 451
G +G ++ E + E E E+ + +EEEEE+E++++G P D P + + +
Sbjct: 853 GSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEEPLSLDWPETRQKQAIYL 912
Query: 452 FTWPLSFVLYFTVPNCNKPRWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVI 511
F P+ F L+ TVP+ + K+F+ TF S +WIA FSY+MVW +G T+GI + I
Sbjct: 913 FLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIMWIAMFSYLMVWWAHQVGETIGISEEI 972
Query: 512 MGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYG 571
MG+T LAAGTS+PD + S+IVAR+G+GDMAVS+S+GSN+FDI +GL +PW L +L ++
Sbjct: 973 MGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGL 1031
Query: 572 SYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCLLLYGVFLCFSIMTEFN 631
+ ++S GL ++ LL + + + KW+++K LG LLY VFL S+M E
Sbjct: 1032 QPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLEDR 1091
Query: 632 VFT 634
+ +
Sbjct: 1092 IIS 1094
Score = 50.4 bits (119), Expect = 5e-06
Identities = 33/122 (27%), Positives = 64/122 (52%), Gaps = 4/122 (3%)
Query: 138 KICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGV 197
++ E + +SE++ G T +AAG+S P+L TSVI GD+ V + VGS +F+I + V
Sbjct: 961 QVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPV 1020
Query: 198 CGLFAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVS---WWESLVL-VLMYLIYIV 253
L + L + + ++ + ++ L++ ++ W + +L M+L+Y V
Sbjct: 1021 PWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFV 1080
Query: 254 IM 255
+
Sbjct: 1081 FL 1082
Score = 38.5 bits (88), Expect = 0.019
Identities = 21/59 (35%), Positives = 32/59 (54%)
Query: 500 IIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLG 558
+I L I + + G TF+AAG S P+ SLI ++ + +GS VF+IL +G
Sbjct: 483 VITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIG 541
>gi|45504369 solute carrier family 24, member 5 [Homo sapiens]
Length = 500
Score = 196 bits (497), Expect = 7e-50
Identities = 94/211 (44%), Positives = 136/211 (64%), Gaps = 1/211 (0%)
Query: 432 EGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFASSTLWIAAFS 491
E P + F+ P L+ + W + P+ +L+ T P+C K W+ +F++TF S +WI+AF+
Sbjct: 290 EDPPSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFT 349
Query: 492 YMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVF 551
Y++VWMVTI G TL IPD +MG+T LAAGTS+PD +AS++VAR+G GDMA+SN +GSNVF
Sbjct: 350 YILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVF 409
Query: 552 DILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLG 611
D+L LG+PW ++T ++ + +NSRGL Y L S+ VH N W+LD+KLG
Sbjct: 410 DMLC-LGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLG 468
Query: 612 CGCLLLYGVFLCFSIMTEFNVFTFVNLPMCG 642
CLL Y S++ E + + CG
Sbjct: 469 IVCLLSYLGLATLSVLYELGIIGNNKIRGCG 499
Score = 193 bits (491), Expect = 4e-49
Identities = 90/181 (49%), Positives = 128/181 (70%)
Query: 83 NSKNCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDDFFVPSLEKICER 142
NS C EFP FT ++RR G ++++ L +YMF A++IVCD++F+PSLE I E
Sbjct: 42 NSTQCVISPSSEFPEGFFTRQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIISES 101
Query: 143 LHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFA 202
L LS+DVAG TFMAAGSSAPEL T+ +GVFITKGD+G+ TI+GSA++N+L I CGL +
Sbjct: 102 LGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLS 161
Query: 203 GQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVIMKYNACIH 262
V LS W L RD YT+S A++ IYD +V W+E +L+L+Y +Y++++ ++ I+
Sbjct: 162 NTVSTLSCWPLFRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKIN 221
Query: 263 Q 263
Q
Sbjct: 222 Q 222
Score = 48.1 bits (113), Expect = 2e-05
Identities = 31/94 (32%), Positives = 51/94 (54%), Gaps = 3/94 (3%)
Query: 141 ERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGL 200
E L + + V G T +AAG+S P+ SV+ KGD+ + IVGS VF++LC +G+
Sbjct: 361 ETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLC-LGIPWF 419
Query: 201 FAGQVVALSSWCLL--RDSIYYTLSVIALIVFIY 232
+ S+ + R Y T+S+ I+F++
Sbjct: 420 IKTAFINGSAPAEVNSRGLTYITISLNISIIFLF 453
Score = 42.0 bits (97), Expect = 0.002
Identities = 35/130 (26%), Positives = 64/130 (49%), Gaps = 11/130 (8%)
Query: 500 IIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGL 559
II +LG+ + G TF+AAG+S P+ + + + GD+ +S +GS +++ L+G+
Sbjct: 97 IISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYN-LLGICA 155
Query: 560 PWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCLLLYG 619
L + V S L Y++ A+V ++ + ++ G LL+YG
Sbjct: 156 ACGLLSNTVSTLSCWPLFRDCAAYTIS--AAAVLGIIYDNQVYWYE-----GALLLLIYG 208
Query: 620 VF---LCFSI 626
++ LCF I
Sbjct: 209 LYVLVLCFDI 218
>gi|39995086 solute carrier family 24 member 6 [Homo sapiens]
Length = 584
Score = 81.3 bits (199), Expect = 3e-15
Identities = 58/180 (32%), Positives = 92/180 (51%), Gaps = 5/180 (2%)
Query: 456 LSFVLYFTVPNCNKPRWEKWF-MVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGI 514
L+ V +F + PR F + F +S LWI A + +V ++ +G + + ++G+
Sbjct: 401 LASVTFFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGL 460
Query: 515 TFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYI 574
T LA G S+ D + +ARQG MA S G +F+IL+G+GL LQ + +
Sbjct: 461 TLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSH--TEV 518
Query: 575 RLNSRGLIYSV--GLLLASVFVTVFGVHLNKWQLDKKLGCGCLLLYGVFLCFSIMTEFNV 632
+L GL+ V G L S+ ++ V L +QL + G LL Y FL +++TEF V
Sbjct: 519 KLEPDGLLVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGV 578
Score = 67.4 bits (163), Expect = 4e-11
Identities = 42/156 (26%), Positives = 79/156 (50%), Gaps = 3/156 (1%)
Query: 109 AVVLHVLCAIYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSV 168
AV L+V +Y+F L + FF P+L I L LS +VAG TF+A G+ AP++F+++
Sbjct: 99 AVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSAL 158
Query: 169 IGVFIT-KGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVIAL 227
+ + +G + G+ V + G G+ +S RD ++Y ++V
Sbjct: 159 VAFSDPHTAGLALGALFGAGVLVTTVVAG--GITILHPFMAASRPFFRDIVFYMVAVFLT 216
Query: 228 IVFIYDEKVSWWESLVLVLMYLIYIVIMKYNACIHQ 263
+ ++ +V+ +L + +Y+ Y+V + I+Q
Sbjct: 217 FLMLFRGRVTLAWALGYLGLYVFYVVTVILCTWIYQ 252
>gi|10863913 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform A [Homo sapiens]
Length = 973
Score = 68.2 bits (165), Expect = 2e-11
Identities = 51/177 (28%), Positives = 83/177 (46%), Gaps = 14/177 (7%)
Query: 422 EEEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFA 481
E++++DE +E + FD L TV W VL+ VP W W F
Sbjct: 758 EDDDDDECGEEKLPSCFDYVMHFL-TVFWK-------VLFAFVPPTEY--WNGW--ACFI 805
Query: 482 SSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGM-GDM 540
S L I + + + + G T+G+ D + + F+A GTSVPD AS + A Q D
Sbjct: 806 VSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADA 865
Query: 541 AVSNSIGSNVFDILIGLGLPWALQTL-AVDYGSYIRLNSRGLIYSVGLLLASVFVTV 596
++ N GSN ++ +G+G+ W++ + G +++ L +SV L F+ V
Sbjct: 866 SIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINV 922
Score = 58.5 bits (140), Expect = 2e-08
Identities = 65/243 (26%), Positives = 100/243 (41%), Gaps = 48/243 (19%)
Query: 112 LHVLCAIYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGAT 153
++ + +YMF ++I+ D F + S+E I + +E V+ T
Sbjct: 80 VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
Query: 154 FMAAGSSAPELFTSVIGVF---ITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQ------ 204
MA GSSAPE+ SVI V T GD+G TIVGSA FN+ II +C
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
Query: 205 -----VVALSSWCLLRDS-IYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVI---- 254
++W + + +Y LSVI+ V V WE L+ + I +V
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGV------VEVWEGLLTFFFFPICVVFAWVA 252
Query: 255 ---MKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKKANFHRKASVIM 311
+ + +++ + R K G ++ + D VV NF A V+
Sbjct: 253 DRRLLFYKYVYKRY-RAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLE 311
Query: 312 VDE 314
VDE
Sbjct: 312 VDE 314
Score = 35.4 bits (80), Expect = 0.16
Identities = 33/139 (23%), Positives = 54/139 (38%), Gaps = 21/139 (15%)
Query: 145 LSEDVAGATFMAAGSSAPELFTSVIGVFITK-GDVGVGTIVGSAVFNILCIIGVCGLFA- 202
L + V F+A G+S P+ F S + + D +G + GS N+ IGV A
Sbjct: 831 LKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 890
Query: 203 ------GQVVALSSWCLLRDSIYYTL-SVIALIVFIYDEK------------VSWWESLV 243
G+ +S L +T+ + I + V +Y + S +
Sbjct: 891 IYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCL 950
Query: 244 LVLMYLIYIVIMKYNACIH 262
VL++L+YI A H
Sbjct: 951 FVLLWLLYIFFSSLEAYCH 969
>gi|163914373 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform D [Homo sapiens]
Length = 937
Score = 68.2 bits (165), Expect = 2e-11
Identities = 51/177 (28%), Positives = 83/177 (46%), Gaps = 14/177 (7%)
Query: 422 EEEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFA 481
E++++DE +E + FD L TV W VL+ VP W W F
Sbjct: 722 EDDDDDECGEEKLPSCFDYVMHFL-TVFWK-------VLFAFVPPTEY--WNGW--ACFI 769
Query: 482 SSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGM-GDM 540
S L I + + + + G T+G+ D + + F+A GTSVPD AS + A Q D
Sbjct: 770 VSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADA 829
Query: 541 AVSNSIGSNVFDILIGLGLPWALQTL-AVDYGSYIRLNSRGLIYSVGLLLASVFVTV 596
++ N GSN ++ +G+G+ W++ + G +++ L +SV L F+ V
Sbjct: 830 SIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINV 886
Score = 58.5 bits (140), Expect = 2e-08
Identities = 65/243 (26%), Positives = 100/243 (41%), Gaps = 48/243 (19%)
Query: 112 LHVLCAIYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGAT 153
++ + +YMF ++I+ D F + S+E I + +E V+ T
Sbjct: 80 VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
Query: 154 FMAAGSSAPELFTSVIGVF---ITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQ------ 204
MA GSSAPE+ SVI V T GD+G TIVGSA FN+ II +C
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
Query: 205 -----VVALSSWCLLRDS-IYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVI---- 254
++W + + +Y LSVI+ V V WE L+ + I +V
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGV------VEVWEGLLTFFFFPICVVFAWVA 252
Query: 255 ---MKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKKANFHRKASVIM 311
+ + +++ + R K G ++ + D VV NF A V+
Sbjct: 253 DRRLLFYKYVYKRY-RAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLE 311
Query: 312 VDE 314
VDE
Sbjct: 312 VDE 314
Score = 35.4 bits (80), Expect = 0.16
Identities = 33/139 (23%), Positives = 54/139 (38%), Gaps = 21/139 (15%)
Query: 145 LSEDVAGATFMAAGSSAPELFTSVIGVFITK-GDVGVGTIVGSAVFNILCIIGVCGLFA- 202
L + V F+A G+S P+ F S + + D +G + GS N+ IGV A
Sbjct: 795 LKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 854
Query: 203 ------GQVVALSSWCLLRDSIYYTL-SVIALIVFIYDEK------------VSWWESLV 243
G+ +S L +T+ + I + V +Y + S +
Sbjct: 855 IYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCL 914
Query: 244 LVLMYLIYIVIMKYNACIH 262
VL++L+YI A H
Sbjct: 915 FVLLWLLYIFFSSLEAYCH 933
>gi|163914371 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform C [Homo sapiens]
Length = 960
Score = 68.2 bits (165), Expect = 2e-11
Identities = 51/177 (28%), Positives = 83/177 (46%), Gaps = 14/177 (7%)
Query: 422 EEEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFA 481
E++++DE +E + FD L TV W VL+ VP W W F
Sbjct: 745 EDDDDDECGEEKLPSCFDYVMHFL-TVFWK-------VLFAFVPPTEY--WNGW--ACFI 792
Query: 482 SSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGM-GDM 540
S L I + + + + G T+G+ D + + F+A GTSVPD AS + A Q D
Sbjct: 793 VSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADA 852
Query: 541 AVSNSIGSNVFDILIGLGLPWALQTL-AVDYGSYIRLNSRGLIYSVGLLLASVFVTV 596
++ N GSN ++ +G+G+ W++ + G +++ L +SV L F+ V
Sbjct: 853 SIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINV 909
Score = 58.5 bits (140), Expect = 2e-08
Identities = 65/243 (26%), Positives = 100/243 (41%), Gaps = 48/243 (19%)
Query: 112 LHVLCAIYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGAT 153
++ + +YMF ++I+ D F + S+E I + +E V+ T
Sbjct: 80 VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
Query: 154 FMAAGSSAPELFTSVIGVF---ITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQ------ 204
MA GSSAPE+ SVI V T GD+G TIVGSA FN+ II +C
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
Query: 205 -----VVALSSWCLLRDS-IYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVI---- 254
++W + + +Y LSVI+ V V WE L+ + I +V
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGV------VEVWEGLLTFFFFPICVVFAWVA 252
Query: 255 ---MKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKKANFHRKASVIM 311
+ + +++ + R K G ++ + D VV NF A V+
Sbjct: 253 DRRLLFYKYVYKRY-RAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLE 311
Query: 312 VDE 314
VDE
Sbjct: 312 VDE 314
Score = 35.4 bits (80), Expect = 0.16
Identities = 33/139 (23%), Positives = 54/139 (38%), Gaps = 21/139 (15%)
Query: 145 LSEDVAGATFMAAGSSAPELFTSVIGVFITK-GDVGVGTIVGSAVFNILCIIGVCGLFA- 202
L + V F+A G+S P+ F S + + D +G + GS N+ IGV A
Sbjct: 818 LKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 877
Query: 203 ------GQVVALSSWCLLRDSIYYTL-SVIALIVFIYDEK------------VSWWESLV 243
G+ +S L +T+ + I + V +Y + S +
Sbjct: 878 IYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCL 937
Query: 244 LVLMYLIYIVIMKYNACIH 262
VL++L+YI A H
Sbjct: 938 FVLLWLLYIFFSSLEAYCH 956
>gi|163914369 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform B [Homo sapiens]
Length = 968
Score = 68.2 bits (165), Expect = 2e-11
Identities = 51/177 (28%), Positives = 83/177 (46%), Gaps = 14/177 (7%)
Query: 422 EEEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFA 481
E++++DE +E + FD L TV W VL+ VP W W F
Sbjct: 753 EDDDDDECGEEKLPSCFDYVMHFL-TVFWK-------VLFAFVPPTEY--WNGW--ACFI 800
Query: 482 SSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGM-GDM 540
S L I + + + + G T+G+ D + + F+A GTSVPD AS + A Q D
Sbjct: 801 VSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADA 860
Query: 541 AVSNSIGSNVFDILIGLGLPWALQTL-AVDYGSYIRLNSRGLIYSVGLLLASVFVTV 596
++ N GSN ++ +G+G+ W++ + G +++ L +SV L F+ V
Sbjct: 861 SIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINV 917
Score = 58.5 bits (140), Expect = 2e-08
Identities = 65/243 (26%), Positives = 100/243 (41%), Gaps = 48/243 (19%)
Query: 112 LHVLCAIYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAGAT 153
++ + +YMF ++I+ D F + S+E I + +E V+ T
Sbjct: 80 VYFVAMVYMFLGVSIIADRF-MSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLT 138
Query: 154 FMAAGSSAPELFTSVIGVF---ITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQ------ 204
MA GSSAPE+ SVI V T GD+G TIVGSA FN+ II +C
Sbjct: 139 LMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI 198
Query: 205 -----VVALSSWCLLRDS-IYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVI---- 254
++W + + +Y LSVI+ V V WE L+ + I +V
Sbjct: 199 KHLRVFFVTAAWSIFAYTWLYIILSVISPGV------VEVWEGLLTFFFFPICVVFAWVA 252
Query: 255 ---MKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKKANFHRKASVIM 311
+ + +++ + R K G ++ + D VV NF A V+
Sbjct: 253 DRRLLFYKYVYKRY-RAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLE 311
Query: 312 VDE 314
VDE
Sbjct: 312 VDE 314
Score = 35.4 bits (80), Expect = 0.16
Identities = 33/139 (23%), Positives = 54/139 (38%), Gaps = 21/139 (15%)
Query: 145 LSEDVAGATFMAAGSSAPELFTSVIGVFITK-GDVGVGTIVGSAVFNILCIIGVCGLFA- 202
L + V F+A G+S P+ F S + + D +G + GS N+ IGV A
Sbjct: 826 LKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 885
Query: 203 ------GQVVALSSWCLLRDSIYYTL-SVIALIVFIYDEK------------VSWWESLV 243
G+ +S L +T+ + I + V +Y + S +
Sbjct: 886 IYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCL 945
Query: 244 LVLMYLIYIVIMKYNACIH 262
VL++L+YI A H
Sbjct: 946 FVLLWLLYIFFSSLEAYCH 964
>gi|57163987 solute carrier family 8 member 2 [Homo sapiens]
Length = 921
Score = 66.2 bits (160), Expect = 9e-11
Identities = 56/179 (31%), Positives = 84/179 (46%), Gaps = 16/179 (8%)
Query: 421 DEEEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTF 480
DEEEEED +E + FD L TV W VL+ VP P F
Sbjct: 705 DEEEEEDGSREERLPSCFDYVMHFL-TVFWK-------VLFACVP----PTEYCHGWACF 752
Query: 481 ASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGM-GD 539
S L I + ++ + + G T+G+ D + + F+A GTS+PD AS + A Q D
Sbjct: 753 GVSILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCAD 812
Query: 540 MAVSNSIGSNVFDILIGLGLPWALQTL--AVDYGSYIRLNSRGLIYSVGLLLASVFVTV 596
++ N GSN ++ +GLG+ W++ + AV G + + L +SV L FV +
Sbjct: 813 ASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQ-GRPFEVRTGTLAFSVTLFTVFAFVGI 870
Score = 58.5 bits (140), Expect = 2e-08
Identities = 59/217 (27%), Positives = 96/217 (44%), Gaps = 43/217 (19%)
Query: 71 NDTLTSEDAGLRNSKNCTEPALHEF--PNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVC 128
ND+ TS G + S C L P+D + + V++ + +YMF ++I+
Sbjct: 34 NDSDTST-GGCQGSYRCQPGVLLPVWEPDDPSLGD--KAARAVVYFVAMVYMFLGVSIIA 90
Query: 129 DDFFVPSLEKICERLH------------------LSEDVAGATFMAAGSSAPELFTSVIG 170
D F ++E I + +E V+ T MA GSSAPE+ SVI
Sbjct: 91 DRFMA-AIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIE 149
Query: 171 VF---ITKGDVGVGTIVGSAVFNILCIIGVC--GLFAGQ---------VVALSSWCLLRD 216
V G++G GTIVGSA FN+ +I VC + AG+ +SW
Sbjct: 150 VCGHNFQAGELGPGTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHLRVFFVTASW----- 204
Query: 217 SIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIV 253
SI+ + + ++ V WE+L+ ++ + + +V
Sbjct: 205 SIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCVV 241
Score = 32.7 bits (73), Expect = 1.1
Identities = 16/54 (29%), Positives = 26/54 (48%), Gaps = 1/54 (1%)
Query: 145 LSEDVAGATFMAAGSSAPELFTSVIGVFITK-GDVGVGTIVGSAVFNILCIIGV 197
L + V F+A G+S P+ F S + + D +G + GS N+ +GV
Sbjct: 779 LKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGV 832
>gi|17865805 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform B precursor [Homo sapiens]
Length = 924
Score = 64.7 bits (156), Expect = 3e-10
Identities = 53/176 (30%), Positives = 83/176 (47%), Gaps = 14/176 (7%)
Query: 423 EEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFAS 482
+E+EDE +E + FD L TV W VL+ VP P FA
Sbjct: 710 DEDEDESGEERLPSCFDYVMHFL-TVFWK-------VLFACVP----PTEYCHGWACFAV 757
Query: 483 STLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGM-GDMA 541
S L I + ++ + + G T+G+ D + + F+A GTSVPD AS A Q + D +
Sbjct: 758 SILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADAS 817
Query: 542 VSNSIGSNVFDILIGLGLPWALQTLA-VDYGSYIRLNSRGLIYSVGLLLASVFVTV 596
+ N GSN ++ +G+GL W++ + G +++ L +SV L FV +
Sbjct: 818 IGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCI 873
Score = 60.5 bits (145), Expect = 5e-09
Identities = 42/111 (37%), Positives = 58/111 (52%), Gaps = 24/111 (21%)
Query: 110 VVLHVLCAIYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAG 151
V+++ + IYMF ++I+ D F S+E I + +E V+
Sbjct: 77 VIVYFVALIYMFLGVSIIADRFMA-SIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135
Query: 152 ATFMAAGSSAPELFTSVIGV----FITKGDVGVGTIVGSAVFNILCIIGVC 198
T MA GSSAPE+ S+I V FI GD+G TIVGSA FN+ IIG+C
Sbjct: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGIC 185
Score = 33.1 bits (74), Expect = 0.81
Identities = 18/54 (33%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 509 DVIMGITFLAAGTSVPDCMASLI-VARQGM--GDMAVSNSIGSNVFDILIGLGL 559
+ + +T +A G+S P+ + SLI V G GD+ S +GS F++ I +G+
Sbjct: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
Score = 33.1 bits (74), Expect = 0.81
Identities = 22/89 (24%), Positives = 36/89 (40%), Gaps = 6/89 (6%)
Query: 145 LSEDVAGATFMAAGSSAPELFTS-VIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAG 203
L + V F+A G+S P+ F S + D +G + GS N+ IG+
Sbjct: 782 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL-----A 836
Query: 204 QVVALSSWCLLRDSIYYTLSVIALIVFIY 232
VA W L + + +A V ++
Sbjct: 837 WSVAAIYWALQGQEFHVSAGTLAFSVTLF 865
>gi|33946308 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform F [Homo sapiens]
Length = 284
Score = 64.7 bits (156), Expect = 3e-10
Identities = 53/176 (30%), Positives = 83/176 (47%), Gaps = 14/176 (7%)
Query: 423 EEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFAS 482
+E+EDE +E + FD L TV W VL+ VP P FA
Sbjct: 70 DEDEDESGEERLPSCFDYVMHFL-TVFWK-------VLFACVP----PTEYCHGWACFAV 117
Query: 483 STLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGM-GDMA 541
S L I + ++ + + G T+G+ D + + F+A GTSVPD AS A Q + D +
Sbjct: 118 SILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADAS 177
Query: 542 VSNSIGSNVFDILIGLGLPWALQTLA-VDYGSYIRLNSRGLIYSVGLLLASVFVTV 596
+ N GSN ++ +G+GL W++ + G +++ L +SV L FV +
Sbjct: 178 IGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCI 233
Score = 33.1 bits (74), Expect = 0.81
Identities = 22/89 (24%), Positives = 36/89 (40%), Gaps = 6/89 (6%)
Query: 145 LSEDVAGATFMAAGSSAPELFTS-VIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAG 203
L + V F+A G+S P+ F S + D +G + GS N+ IG+
Sbjct: 142 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL-----A 196
Query: 204 QVVALSSWCLLRDSIYYTLSVIALIVFIY 232
VA W L + + +A V ++
Sbjct: 197 WSVAAIYWALQGQEFHVSAGTLAFSVTLF 225
>gi|33946304 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform D precursor [Homo sapiens]
Length = 921
Score = 64.7 bits (156), Expect = 3e-10
Identities = 53/176 (30%), Positives = 83/176 (47%), Gaps = 14/176 (7%)
Query: 423 EEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFAS 482
+E+EDE +E + FD L TV W VL+ VP P FA
Sbjct: 707 DEDEDESGEERLPSCFDYVMHFL-TVFWK-------VLFACVP----PTEYCHGWACFAV 754
Query: 483 STLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGM-GDMA 541
S L I + ++ + + G T+G+ D + + F+A GTSVPD AS A Q + D +
Sbjct: 755 SILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADAS 814
Query: 542 VSNSIGSNVFDILIGLGLPWALQTLA-VDYGSYIRLNSRGLIYSVGLLLASVFVTV 596
+ N GSN ++ +G+GL W++ + G +++ L +SV L FV +
Sbjct: 815 IGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCI 870
Score = 60.5 bits (145), Expect = 5e-09
Identities = 42/111 (37%), Positives = 58/111 (52%), Gaps = 24/111 (21%)
Query: 110 VVLHVLCAIYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAG 151
V+++ + IYMF ++I+ D F S+E I + +E V+
Sbjct: 77 VIVYFVALIYMFLGVSIIADRFMA-SIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135
Query: 152 ATFMAAGSSAPELFTSVIGV----FITKGDVGVGTIVGSAVFNILCIIGVC 198
T MA GSSAPE+ S+I V FI GD+G TIVGSA FN+ IIG+C
Sbjct: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGIC 185
Score = 33.1 bits (74), Expect = 0.81
Identities = 18/54 (33%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 509 DVIMGITFLAAGTSVPDCMASLI-VARQGM--GDMAVSNSIGSNVFDILIGLGL 559
+ + +T +A G+S P+ + SLI V G GD+ S +GS F++ I +G+
Sbjct: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
Score = 33.1 bits (74), Expect = 0.81
Identities = 22/89 (24%), Positives = 36/89 (40%), Gaps = 6/89 (6%)
Query: 145 LSEDVAGATFMAAGSSAPELFTS-VIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAG 203
L + V F+A G+S P+ F S + D +G + GS N+ IG+
Sbjct: 779 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL-----A 833
Query: 204 QVVALSSWCLLRDSIYYTLSVIALIVFIY 232
VA W L + + +A V ++
Sbjct: 834 WSVAAIYWALQGQEFHVSAGTLAFSVTLF 862
>gi|194354001 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform G [Homo sapiens]
Length = 298
Score = 64.7 bits (156), Expect = 3e-10
Identities = 53/176 (30%), Positives = 83/176 (47%), Gaps = 14/176 (7%)
Query: 423 EEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFAS 482
+E+EDE +E + FD L TV W VL+ VP P FA
Sbjct: 84 DEDEDESGEERLPSCFDYVMHFL-TVFWK-------VLFACVP----PTEYCHGWACFAV 131
Query: 483 STLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGM-GDMA 541
S L I + ++ + + G T+G+ D + + F+A GTSVPD AS A Q + D +
Sbjct: 132 SILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADAS 191
Query: 542 VSNSIGSNVFDILIGLGLPWALQTLA-VDYGSYIRLNSRGLIYSVGLLLASVFVTV 596
+ N GSN ++ +G+GL W++ + G +++ L +SV L FV +
Sbjct: 192 IGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCI 247
Score = 33.1 bits (74), Expect = 0.81
Identities = 22/89 (24%), Positives = 36/89 (40%), Gaps = 6/89 (6%)
Query: 145 LSEDVAGATFMAAGSSAPELFTS-VIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAG 203
L + V F+A G+S P+ F S + D +G + GS N+ IG+
Sbjct: 156 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL-----A 210
Query: 204 QVVALSSWCLLRDSIYYTLSVIALIVFIY 232
VA W L + + +A V ++
Sbjct: 211 WSVAAIYWALQGQEFHVSAGTLAFSVTLF 239
>gi|15147254 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform A precursor [Homo sapiens]
Length = 925
Score = 64.7 bits (156), Expect = 3e-10
Identities = 53/176 (30%), Positives = 83/176 (47%), Gaps = 14/176 (7%)
Query: 423 EEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFAS 482
+E+EDE +E + FD L TV W VL+ VP P FA
Sbjct: 711 DEDEDESGEERLPSCFDYVMHFL-TVFWK-------VLFACVP----PTEYCHGWACFAV 758
Query: 483 STLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGM-GDMA 541
S L I + ++ + + G T+G+ D + + F+A GTSVPD AS A Q + D +
Sbjct: 759 SILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADAS 818
Query: 542 VSNSIGSNVFDILIGLGLPWALQTLA-VDYGSYIRLNSRGLIYSVGLLLASVFVTV 596
+ N GSN ++ +G+GL W++ + G +++ L +SV L FV +
Sbjct: 819 IGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCI 874
Score = 60.5 bits (145), Expect = 5e-09
Identities = 42/111 (37%), Positives = 58/111 (52%), Gaps = 24/111 (21%)
Query: 110 VVLHVLCAIYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAG 151
V+++ + IYMF ++I+ D F S+E I + +E V+
Sbjct: 77 VIVYFVALIYMFLGVSIIADRFMA-SIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135
Query: 152 ATFMAAGSSAPELFTSVIGV----FITKGDVGVGTIVGSAVFNILCIIGVC 198
T MA GSSAPE+ S+I V FI GD+G TIVGSA FN+ IIG+C
Sbjct: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGIC 185
Score = 33.1 bits (74), Expect = 0.81
Identities = 18/54 (33%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 509 DVIMGITFLAAGTSVPDCMASLI-VARQGM--GDMAVSNSIGSNVFDILIGLGL 559
+ + +T +A G+S P+ + SLI V G GD+ S +GS F++ I +G+
Sbjct: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
Score = 33.1 bits (74), Expect = 0.81
Identities = 22/89 (24%), Positives = 36/89 (40%), Gaps = 6/89 (6%)
Query: 145 LSEDVAGATFMAAGSSAPELFTS-VIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAG 203
L + V F+A G+S P+ F S + D +G + GS N+ IG+
Sbjct: 783 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL-----A 837
Query: 204 QVVALSSWCLLRDSIYYTLSVIALIVFIY 232
VA W L + + +A V ++
Sbjct: 838 WSVAAIYWALQGQEFHVSAGTLAFSVTLF 866
>gi|33946311 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform C precursor [Homo sapiens]
Length = 927
Score = 64.7 bits (156), Expect = 3e-10
Identities = 53/176 (30%), Positives = 83/176 (47%), Gaps = 14/176 (7%)
Query: 423 EEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFAS 482
+E+EDE +E + FD L TV W VL+ VP P FA
Sbjct: 713 DEDEDESGEERLPSCFDYVMHFL-TVFWK-------VLFACVP----PTEYCHGWACFAV 760
Query: 483 STLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGM-GDMA 541
S L I + ++ + + G T+G+ D + + F+A GTSVPD AS A Q + D +
Sbjct: 761 SILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADAS 820
Query: 542 VSNSIGSNVFDILIGLGLPWALQTLA-VDYGSYIRLNSRGLIYSVGLLLASVFVTV 596
+ N GSN ++ +G+GL W++ + G +++ L +SV L FV +
Sbjct: 821 IGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCI 876
Score = 60.5 bits (145), Expect = 5e-09
Identities = 42/111 (37%), Positives = 58/111 (52%), Gaps = 24/111 (21%)
Query: 110 VVLHVLCAIYMFYALAIVCDDFFVPSLEKICERLH------------------LSEDVAG 151
V+++ + IYMF ++I+ D F S+E I + +E V+
Sbjct: 77 VIVYFVALIYMFLGVSIIADRFMA-SIEVITSQEREVTIKKPNGETSTTTIRVWNETVSN 135
Query: 152 ATFMAAGSSAPELFTSVIGV----FITKGDVGVGTIVGSAVFNILCIIGVC 198
T MA GSSAPE+ S+I V FI GD+G TIVGSA FN+ IIG+C
Sbjct: 136 LTLMALGSSAPEILLSLIEVCGHGFIA-GDLGPSTIVGSAAFNMFIIIGIC 185
Score = 33.1 bits (74), Expect = 0.81
Identities = 18/54 (33%), Positives = 31/54 (57%), Gaps = 3/54 (5%)
Query: 509 DVIMGITFLAAGTSVPDCMASLI-VARQGM--GDMAVSNSIGSNVFDILIGLGL 559
+ + +T +A G+S P+ + SLI V G GD+ S +GS F++ I +G+
Sbjct: 131 ETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGI 184
Score = 33.1 bits (74), Expect = 0.81
Identities = 22/89 (24%), Positives = 36/89 (40%), Gaps = 6/89 (6%)
Query: 145 LSEDVAGATFMAAGSSAPELFTS-VIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAG 203
L + V F+A G+S P+ F S + D +G + GS N+ IG+
Sbjct: 785 LKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGL-----A 839
Query: 204 QVVALSSWCLLRDSIYYTLSVIALIVFIY 232
VA W L + + +A V ++
Sbjct: 840 WSVAAIYWALQGQEFHVSAGTLAFSVTLF 868
>gi|17975763 myelin transcription factor 1 [Homo sapiens]
Length = 1121
Score = 40.8 bits (94), Expect = 0.004
Identities = 17/53 (32%), Positives = 31/53 (58%)
Query: 380 TVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDE 432
++E+ S+ +G+ +D E E E E+E+ E +EEEEE+E+++E
Sbjct: 239 SLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEE 291
Score = 34.7 bits (78), Expect = 0.28
Identities = 15/37 (40%), Positives = 22/37 (59%)
Query: 401 DDVVAEAGNETENENEDNENDEEEEEDEDDDEGPYTP 437
+D E E E E E+ E +EEEEE+E+++E P
Sbjct: 273 EDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAP 309
Score = 33.1 bits (74), Expect = 0.81
Identities = 14/46 (30%), Positives = 24/46 (52%)
Query: 387 PSSAPDRGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDE 432
P S D + + + E E E E+ E +EE+EE+E+++E
Sbjct: 237 PQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEE 282
>gi|4503257 death-domain associated protein isoform a [Homo sapiens]
Length = 740
Score = 40.4 bits (93), Expect = 0.005
Identities = 33/137 (24%), Positives = 58/137 (42%), Gaps = 28/137 (20%)
Query: 296 VLLKKANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINER 355
VL ++ +R ++ +DE++S Y SE G ER
Sbjct: 356 VLARRLRENRSLAMSRLDEVISKYAMLQDKSEEG------------------------ER 391
Query: 356 QRLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENEN 415
++ RA G S + P + ++++G GPS +G R + E E++ E
Sbjct: 392 KK---RRARLQGTSSHSADTP-EASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEE 447
Query: 416 EDNENDEEEEEDEDDDE 432
E+ E +EEEE + ++E
Sbjct: 448 EEEEEEEEEEATDSEEE 464
>gi|215422388 death-domain associated protein isoform a [Homo
sapiens]
Length = 740
Score = 40.4 bits (93), Expect = 0.005
Identities = 33/137 (24%), Positives = 58/137 (42%), Gaps = 28/137 (20%)
Query: 296 VLLKKANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINER 355
VL ++ +R ++ +DE++S Y SE G ER
Sbjct: 356 VLARRLRENRSLAMSRLDEVISKYAMLQDKSEEG------------------------ER 391
Query: 356 QRLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENEN 415
++ RA G S + P + ++++G GPS +G R + E E++ E
Sbjct: 392 KK---RRARLQGTSSHSADTP-EASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEE 447
Query: 416 EDNENDEEEEEDEDDDE 432
E+ E +EEEE + ++E
Sbjct: 448 EEEEEEEEEEATDSEEE 464
>gi|215422366 death-domain associated protein isoform b [Homo
sapiens]
Length = 752
Score = 40.4 bits (93), Expect = 0.005
Identities = 33/137 (24%), Positives = 58/137 (42%), Gaps = 28/137 (20%)
Query: 296 VLLKKANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINER 355
VL ++ +R ++ +DE++S Y SE G ER
Sbjct: 368 VLARRLRENRSLAMSRLDEVISKYAMLQDKSEEG------------------------ER 403
Query: 356 QRLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENEN 415
++ RA G S + P + ++++G GPS +G R + E E++ E
Sbjct: 404 KK---RRARLQGTSSHSADTP-EASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEE 459
Query: 416 EDNENDEEEEEDEDDDE 432
E+ E +EEEE + ++E
Sbjct: 460 EEEEEEEEEEATDSEEE 476
>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
Length = 1390
Score = 40.4 bits (93), Expect = 0.005
Identities = 29/115 (25%), Positives = 53/115 (46%), Gaps = 13/115 (11%)
Query: 360 NSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNE 419
N YT G+ + I+ + T +N G + + G + DD E+ED+E
Sbjct: 215 NLNMYTRGKQK-DIQRTDEETTDNQEGSVESSEEGEDQEHEDD----------GEDEDDE 263
Query: 420 NDEEEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEK 474
+D+++++D+DDD+ D G+ E K + +Y+ P KPR ++
Sbjct: 264 DDDDDDDDDDDDDDE-DDEDEEDGEEENQKRYYLRQRKATVYYQAP-LEKPRHQR 316
>gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4
[Homo sapiens]
Length = 2073
Score = 40.4 bits (93), Expect = 0.005
Identities = 26/80 (32%), Positives = 43/80 (53%), Gaps = 9/80 (11%)
Query: 354 ERQRLINSRAYTN-GESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETE 412
E Q ++++RA + ++V K H+ P S P G G + +++ +E E
Sbjct: 1021 EEQEILSTRANSRQSPAKVQSKNKYLHS------PESRPVTGERGQLLE--LSKESSEEE 1072
Query: 413 NENEDNENDEEEEEDEDDDE 432
E ED E +EEEEE+E+D+E
Sbjct: 1073 EEEEDEEEEEEEEEEEEDEE 1092
Score = 35.0 bits (79), Expect = 0.21
Identities = 27/115 (23%), Positives = 48/115 (41%), Gaps = 16/115 (13%)
Query: 339 PPKTRLSMASRMLINERQRLINSRAYTNGESEVAIKIPIKHTVE----------NGTGPS 388
PP+T + ++ + E++ + S + I+ +K T E T
Sbjct: 1276 PPETPMEPDEQVTVEEQKETSEGKT---SPSPIRIEEEVKETGEALLPQEENRREETCAP 1332
Query: 389 SAPDRGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDEGPYTPFDTPSG 443
+P+ DD++ E E E E+ E +EEEEE+ +++EG P G
Sbjct: 1333 VSPNTSPGEKPEDDLIKP---EEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDG 1384
>gi|140972063 protein phosphatase 1, regulatory subunit 9B [Homo
sapiens]
Length = 817
Score = 40.0 bits (92), Expect = 0.007
Identities = 29/92 (31%), Positives = 40/92 (43%), Gaps = 12/92 (13%)
Query: 362 RAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRD-------DVVAEAGNETENE 414
+A E E A P + V NG P AP+ + D DV A +G
Sbjct: 347 KAQAAPEKEAAAVAPPERGVGNGRAPDVAPEEVDESKKEDFSEADLVDVSAYSGL----- 401
Query: 415 NEDNENDEEEEEDEDDDEGPYTPFDTPSGKLE 446
ED+ EE+DEDD+E P++ SG +E
Sbjct: 402 GEDSAGSALEEDDEDDEEDGEPPYEPESGCVE 433
>gi|86262149 zinc finger and BTB domain containing 7C [Homo sapiens]
Length = 619
Score = 40.0 bits (92), Expect = 0.007
Identities = 17/38 (44%), Positives = 25/38 (65%)
Query: 394 GVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDD 431
G +G DD + +E +++ ED E +EEEEED+DDD
Sbjct: 130 GGDGGEEDDKEDDDDDEDDDDEEDEEEEEEEEEDDDDD 167
Score = 33.5 bits (75), Expect = 0.62
Identities = 10/27 (37%), Positives = 22/27 (81%)
Query: 406 EAGNETENENEDNENDEEEEEDEDDDE 432
+ G E + E++D++ D+++EEDE+++E
Sbjct: 132 DGGEEDDKEDDDDDEDDDDEEDEEEEE 158
Score = 30.4 bits (67), Expect = 5.3
Identities = 8/31 (25%), Positives = 25/31 (80%)
Query: 402 DVVAEAGNETENENEDNENDEEEEEDEDDDE 432
+++ G+ E +++++++D+E+++DE+D+E
Sbjct: 125 EIMEPGGDGGEEDDKEDDDDDEDDDDEEDEE 155
>gi|115529449 upstream binding transcription factor, RNA polymerase
I isoform b [Homo sapiens]
Length = 727
Score = 39.7 bits (91), Expect = 0.009
Identities = 20/62 (32%), Positives = 36/62 (58%), Gaps = 3/62 (4%)
Query: 382 ENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDEGPYTPFDTP 441
ENG S+ D G + + +E G+E E ++ED ++DE+++EDED++ + +
Sbjct: 661 ENG---DSSEDGGDSSESSSEDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSSSSSS 717
Query: 442 SG 443
SG
Sbjct: 718 SG 719
Score = 35.8 bits (81), Expect = 0.13
Identities = 12/27 (44%), Positives = 25/27 (92%)
Query: 406 EAGNETENENEDNENDEEEEEDEDDDE 432
++ +E+E ++E++E+DE+E+E+E+DDE
Sbjct: 635 QSKSESEEDDEEDEDDEDEDEEEEDDE 661
Score = 33.5 bits (75), Expect = 0.62
Identities = 13/41 (31%), Positives = 23/41 (56%)
Query: 393 RGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDEG 433
RG N + E++ ED ++++E+EE+EDD+ G
Sbjct: 623 RGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENG 663
Score = 30.8 bits (68), Expect = 4.0
Identities = 11/27 (40%), Positives = 19/27 (70%)
Query: 405 AEAGNETENENEDNENDEEEEEDEDDD 431
+E+ + E + +D + DEEEE+DE+ D
Sbjct: 638 SESEEDDEEDEDDEDEDEEEEDDENGD 664
Score = 30.0 bits (66), Expect = 6.9
Identities = 10/23 (43%), Positives = 20/23 (86%)
Query: 410 ETENENEDNENDEEEEEDEDDDE 432
E + E+ED+E+++EEEED+++ +
Sbjct: 642 EDDEEDEDDEDEDEEEEDDENGD 664
>gi|115529451 upstream binding transcription factor, RNA polymerase
I isoform b [Homo sapiens]
Length = 727
Score = 39.7 bits (91), Expect = 0.009
Identities = 20/62 (32%), Positives = 36/62 (58%), Gaps = 3/62 (4%)
Query: 382 ENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDEGPYTPFDTP 441
ENG S+ D G + + +E G+E E ++ED ++DE+++EDED++ + +
Sbjct: 661 ENG---DSSEDGGDSSESSSEDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSSSSSS 717
Query: 442 SG 443
SG
Sbjct: 718 SG 719
Score = 35.8 bits (81), Expect = 0.13
Identities = 12/27 (44%), Positives = 25/27 (92%)
Query: 406 EAGNETENENEDNENDEEEEEDEDDDE 432
++ +E+E ++E++E+DE+E+E+E+DDE
Sbjct: 635 QSKSESEEDDEEDEDDEDEDEEEEDDE 661
Score = 33.5 bits (75), Expect = 0.62
Identities = 13/41 (31%), Positives = 23/41 (56%)
Query: 393 RGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDEG 433
RG N + E++ ED ++++E+EE+EDD+ G
Sbjct: 623 RGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENG 663
Score = 30.8 bits (68), Expect = 4.0
Identities = 11/27 (40%), Positives = 19/27 (70%)
Query: 405 AEAGNETENENEDNENDEEEEEDEDDD 431
+E+ + E + +D + DEEEE+DE+ D
Sbjct: 638 SESEEDDEEDEDDEDEDEEEEDDENGD 664
Score = 30.0 bits (66), Expect = 6.9
Identities = 10/23 (43%), Positives = 20/23 (86%)
Query: 410 ETENENEDNENDEEEEEDEDDDE 432
E + E+ED+E+++EEEED+++ +
Sbjct: 642 EDDEEDEDDEDEDEEEEDDENGD 664
>gi|7657671 upstream binding transcription factor, RNA polymerase I
isoform a [Homo sapiens]
Length = 764
Score = 39.7 bits (91), Expect = 0.009
Identities = 20/62 (32%), Positives = 36/62 (58%), Gaps = 3/62 (4%)
Query: 382 ENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDEGPYTPFDTP 441
ENG S+ D G + + +E G+E E ++ED ++DE+++EDED++ + +
Sbjct: 698 ENG---DSSEDGGDSSESSSEDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSSSSSS 754
Query: 442 SG 443
SG
Sbjct: 755 SG 756
Score = 35.8 bits (81), Expect = 0.13
Identities = 12/27 (44%), Positives = 25/27 (92%)
Query: 406 EAGNETENENEDNENDEEEEEDEDDDE 432
++ +E+E ++E++E+DE+E+E+E+DDE
Sbjct: 672 QSKSESEEDDEEDEDDEDEDEEEEDDE 698
Score = 33.5 bits (75), Expect = 0.62
Identities = 13/41 (31%), Positives = 23/41 (56%)
Query: 393 RGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDEG 433
RG N + E++ ED ++++E+EE+EDD+ G
Sbjct: 660 RGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENG 700
Score = 30.8 bits (68), Expect = 4.0
Identities = 11/27 (40%), Positives = 19/27 (70%)
Query: 405 AEAGNETENENEDNENDEEEEEDEDDD 431
+E+ + E + +D + DEEEE+DE+ D
Sbjct: 675 SESEEDDEEDEDDEDEDEEEEDDENGD 701
Score = 30.0 bits (66), Expect = 6.9
Identities = 10/23 (43%), Positives = 20/23 (86%)
Query: 410 ETENENEDNENDEEEEEDEDDDE 432
E + E+ED+E+++EEEED+++ +
Sbjct: 679 EDDEEDEDDEDEDEEEEDDENGD 701
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,764,038
Number of Sequences: 37866
Number of extensions: 1063745
Number of successful extensions: 15437
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 316
Number of HSP's successfully gapped in prelim test: 109
Number of HSP's that attempted gapping in prelim test: 9073
Number of HSP's gapped (non-prelim): 3128
length of query: 644
length of database: 18,247,518
effective HSP length: 109
effective length of query: 535
effective length of database: 14,120,124
effective search space: 7554266340
effective search space used: 7554266340
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.