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Search of human proteins with 31563382
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1
[Homo sapiens]
(496 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 1016 0.0
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 1016 0.0
gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [H... 929 0.0
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 579 e-165
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 569 e-162
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 569 e-162
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 569 e-162
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 513 e-145
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 513 e-145
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 331 8e-91
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 331 1e-90
gi|4502023 AKT2 kinase [Homo sapiens] 324 1e-88
gi|62241015 AKT1 kinase [Homo sapiens] 311 9e-85
gi|62241013 AKT1 kinase [Homo sapiens] 311 9e-85
gi|62241011 AKT1 kinase [Homo sapiens] 311 9e-85
gi|133908623 protein kinase C, iota [Homo sapiens] 304 1e-82
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 299 4e-81
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 298 8e-81
gi|4885563 protein kinase C, epsilon [Homo sapiens] 295 6e-80
gi|4506067 protein kinase C, alpha [Homo sapiens] 291 9e-79
gi|28557781 protein kinase C, eta [Homo sapiens] 288 1e-77
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 288 1e-77
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 288 1e-77
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 288 1e-77
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 281 7e-76
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 274 2e-73
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 271 1e-72
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 271 1e-72
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 270 3e-72
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 269 5e-72
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 1016 bits (2626), Expect = 0.0
Identities = 496/496 (100%), Positives = 496/496 (100%)
Query: 1 MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60
MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT
Sbjct: 1 MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60
Query: 61 LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120
LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD
Sbjct: 61 LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120
Query: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180
SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK
Sbjct: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180
Query: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240
RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL
Sbjct: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240
Query: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300
DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV
Sbjct: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300
Query: 301 VLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPP 360
VLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPP
Sbjct: 301 VLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPP 360
Query: 361 FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE 420
FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE
Sbjct: 361 FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE 420
Query: 421 SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD 480
SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD
Sbjct: 421 SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD 480
Query: 481 AFVGFSYAPPSEDLFL 496
AFVGFSYAPPSEDLFL
Sbjct: 481 AFVGFSYAPPSEDLFL 496
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 1016 bits (2626), Expect = 0.0
Identities = 496/496 (100%), Positives = 496/496 (100%)
Query: 1 MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60
MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT
Sbjct: 1 MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60
Query: 61 LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120
LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD
Sbjct: 61 LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120
Query: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180
SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK
Sbjct: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180
Query: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240
RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL
Sbjct: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240
Query: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300
DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV
Sbjct: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300
Query: 301 VLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPP 360
VLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPP
Sbjct: 301 VLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPP 360
Query: 361 FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE 420
FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE
Sbjct: 361 FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE 420
Query: 421 SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD 480
SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD
Sbjct: 421 SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD 480
Query: 481 AFVGFSYAPPSEDLFL 496
AFVGFSYAPPSEDLFL
Sbjct: 481 AFVGFSYAPPSEDLFL 496
>gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [Homo
sapiens]
Length = 464
Score = 929 bits (2401), Expect = 0.0
Identities = 464/496 (93%), Positives = 464/496 (93%), Gaps = 32/496 (6%)
Query: 1 MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60
MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT
Sbjct: 1 MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT 60
Query: 61 LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120
LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD
Sbjct: 61 LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120
Query: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180
SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK
Sbjct: 121 SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK 180
Query: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240
RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL
Sbjct: 181 RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL 240
Query: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300
DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV
Sbjct: 241 DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV 300
Query: 301 VLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPP 360
VLTDFGLCKEGIAISDTTTTFCGTPE PP
Sbjct: 301 VLTDFGLCKEGIAISDTTTTFCGTPE--------------------------------PP 328
Query: 361 FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE 420
FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE
Sbjct: 329 FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE 388
Query: 421 SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD 480
SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD
Sbjct: 389 SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD 448
Query: 481 AFVGFSYAPPSEDLFL 496
AFVGFSYAPPSEDLFL
Sbjct: 449 AFVGFSYAPPSEDLFL 464
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 579 bits (1492), Expect = e-165
Identities = 285/430 (66%), Positives = 338/430 (78%), Gaps = 13/430 (3%)
Query: 67 AMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH-- 124
A L P R F N DP F+KQRR GLN+FIQ + HP+V++ L++ P+
Sbjct: 103 ANILTKPDPRTFWTNDDPAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPE 162
Query: 125 --QSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRK 182
++PS S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K
Sbjct: 163 LMNANPSPPP---------SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHK 213
Query: 183 LDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDF 242
+ FYAVKVLQKK +L +KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD+
Sbjct: 214 AEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDY 273
Query: 243 VNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVL 302
+NGGELF+HLQRER F E RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VL
Sbjct: 274 INGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVL 333
Query: 303 TDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFY 362
TDFGLCKE I + TT+TFCGTPEYLAPEV+ KQPYD TVDWWCLGAVLYEMLYGLPPFY
Sbjct: 334 TDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFY 393
Query: 363 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESL 422
R+ AEMYDNIL+KPL L+P ++ +A +LE LL+KDR RLGAK+DF+EI++H FF +
Sbjct: 394 SRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLI 453
Query: 423 SWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAF 482
+W DL+ KKI PPFNPNV+GP+D+R+FD FTEE VP S+ S D +V ASV EA +AF
Sbjct: 454 NWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAF 513
Query: 483 VGFSYAPPSE 492
+GFSYAPP++
Sbjct: 514 LGFSYAPPTD 523
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 569 bits (1466), Expect = e-162
Identities = 277/411 (67%), Positives = 330/411 (80%), Gaps = 13/411 (3%)
Query: 86 FIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH----QSDPSEDEDERSSQKLH 141
F+KQRR GLN+FIQ + HP+V++ L++ P+ ++PS
Sbjct: 27 FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPP--------- 77
Query: 142 STSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNR 201
S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K + FYAVKVLQKK +L +
Sbjct: 78 SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKK 137
Query: 202 KEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEH 261
KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD++NGGELF+HLQRER F E
Sbjct: 138 KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEP 197
Query: 262 RARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTF 321
RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VLTDFGLCKE I + TT+TF
Sbjct: 198 RARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTF 257
Query: 322 CGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLR 381
CGTPEYLAPEV+ KQPYD TVDWWCLGAVLYEMLYGLPPFY R+ AEMYDNIL+KPL L+
Sbjct: 258 CGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK 317
Query: 382 PGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVA 441
P ++ +A +LE LL+KDR RLGAK+DF+EI++H FF ++W DL+ KKI PPFNPNV+
Sbjct: 318 PNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 377
Query: 442 GPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSE 492
GP+D+R+FD FTEE VP S+ S D +V ASV EA +AF+GFSYAPP++
Sbjct: 378 GPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTD 428
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 569 bits (1466), Expect = e-162
Identities = 277/411 (67%), Positives = 330/411 (80%), Gaps = 13/411 (3%)
Query: 86 FIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH----QSDPSEDEDERSSQKLH 141
F+KQRR GLN+FIQ + HP+V++ L++ P+ ++PS
Sbjct: 41 FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPP--------- 91
Query: 142 STSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNR 201
S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K + FYAVKVLQKK +L +
Sbjct: 92 SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKK 151
Query: 202 KEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEH 261
KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD++NGGELF+HLQRER F E
Sbjct: 152 KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEP 211
Query: 262 RARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTF 321
RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VLTDFGLCKE I + TT+TF
Sbjct: 212 RARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTF 271
Query: 322 CGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLR 381
CGTPEYLAPEV+ KQPYD TVDWWCLGAVLYEMLYGLPPFY R+ AEMYDNIL+KPL L+
Sbjct: 272 CGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK 331
Query: 382 PGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVA 441
P ++ +A +LE LL+KDR RLGAK+DF+EI++H FF ++W DL+ KKI PPFNPNV+
Sbjct: 332 PNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 391
Query: 442 GPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSE 492
GP+D+R+FD FTEE VP S+ S D +V ASV EA +AF+GFSYAPP++
Sbjct: 392 GPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTD 442
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 569 bits (1466), Expect = e-162
Identities = 277/411 (67%), Positives = 330/411 (80%), Gaps = 13/411 (3%)
Query: 86 FIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKH----QSDPSEDEDERSSQKLH 141
F+KQRR GLN+FIQ + HP+V++ L++ P+ ++PS
Sbjct: 55 FMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPP--------- 105
Query: 142 STSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNR 201
S SQ INLGPS NPHAKP+DF FLKVIGKGSFGKVLLA+ K + FYAVKVLQKK +L +
Sbjct: 106 SPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKK 165
Query: 202 KEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEH 261
KE+KHIM+ERNVLLKNVKHPFLVGLH+SFQT +KLYFVLD++NGGELF+HLQRER F E
Sbjct: 166 KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEP 225
Query: 262 RARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTF 321
RARFYAAEIASALGYLHS+ IVYRDLKPENILLDS GH+VLTDFGLCKE I + TT+TF
Sbjct: 226 RARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTF 285
Query: 322 CGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLR 381
CGTPEYLAPEV+ KQPYD TVDWWCLGAVLYEMLYGLPPFY R+ AEMYDNIL+KPL L+
Sbjct: 286 CGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK 345
Query: 382 PGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVA 441
P ++ +A +LE LL+KDR RLGAK+DF+EI++H FF ++W DL+ KKI PPFNPNV+
Sbjct: 346 PNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVS 405
Query: 442 GPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSE 492
GP+D+R+FD FTEE VP S+ S D +V ASV EA +AF+GFSYAPP++
Sbjct: 406 GPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTD 456
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 513 bits (1321), Expect = e-145
Identities = 244/349 (69%), Positives = 289/349 (82%), Gaps = 3/349 (0%)
Query: 146 NINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQK 205
NINLGPS NP+A+PTDFDFLKVIGKG++GKVLLAKRK DG FYAVKVLQKK +L +KEQ
Sbjct: 19 NINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQS 78
Query: 206 HIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARF 265
HIMAER+VLLKNV+HPFLVGL YSFQT EKLYFVLD+VNGGELFFHLQRER F E RARF
Sbjct: 79 HIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARF 138
Query: 266 YAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP 325
YAAE+ASA+GYLHS+ I+YRDLKPENILLD GHVVLTDFGLCKEG+ DTT+TFCGTP
Sbjct: 139 YAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTP 198
Query: 326 EYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVS 385
EYLAPEV+RK+PYD VDWWCLGAVLYEML+GLPPFY +DV++MY+NILH+PL + G +
Sbjct: 199 EYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRT 258
Query: 386 LTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDD 445
+ A +L+ LL KD++ RLG+K DFLEI+NH FF ++W DL K++ PPFNPNV GP D
Sbjct: 259 VAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPAD 318
Query: 446 IRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDL 494
+++FD FT+E V S+ + D AS A AF+GFSYAP +D+
Sbjct: 319 LKHFDPEFTQEAVSKSIGCTPD---TVASSSGASSAFLGFSYAPEDDDI 364
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 513 bits (1321), Expect = e-145
Identities = 244/349 (69%), Positives = 289/349 (82%), Gaps = 3/349 (0%)
Query: 146 NINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQK 205
NINLGPS NP+A+PTDFDFLKVIGKG++GKVLLAKRK DG FYAVKVLQKK +L +KEQ
Sbjct: 79 NINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQS 138
Query: 206 HIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARF 265
HIMAER+VLLKNV+HPFLVGL YSFQT EKLYFVLD+VNGGELFFHLQRER F E RARF
Sbjct: 139 HIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARF 198
Query: 266 YAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTP 325
YAAE+ASA+GYLHS+ I+YRDLKPENILLD GHVVLTDFGLCKEG+ DTT+TFCGTP
Sbjct: 199 YAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTP 258
Query: 326 EYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVS 385
EYLAPEV+RK+PYD VDWWCLGAVLYEML+GLPPFY +DV++MY+NILH+PL + G +
Sbjct: 259 EYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRT 318
Query: 386 LTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDD 445
+ A +L+ LL KD++ RLG+K DFLEI+NH FF ++W DL K++ PPFNPNV GP D
Sbjct: 319 VAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPAD 378
Query: 446 IRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDL 494
+++FD FT+E V S+ + D AS A AF+GFSYAP +D+
Sbjct: 379 LKHFDPEFTQEAVSKSIGCTPD---TVASSSGASSAFLGFSYAPEDDDI 424
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 331 bits (849), Expect = 8e-91
Identities = 180/401 (44%), Positives = 240/401 (59%), Gaps = 26/401 (6%)
Query: 87 IKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSE---------DEDERSS 137
+K R N FI +++ + + +D+P+ + + +E E
Sbjct: 62 MKTERPKPNTFIIRCLQWTTV-----IERTFHVDTPEEREEWTEAIQAVADRLQRQEEER 116
Query: 138 QKLHSTSQNINLGP-----SGNPHAKPT--DFDFLKVIGKGSFGKVLLAKRKLDGKFYAV 190
TSQ N+G S H + T DFD+LK++GKG+FGKV+L + K GK+YA+
Sbjct: 117 MNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAM 176
Query: 191 KVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFF 250
K+L+K++++ + E H + E VL KN +HPFL L YSFQT ++L FV+++VNGGELFF
Sbjct: 177 KILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFF 235
Query: 251 HLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKE 310
HL RER F E R RFY AEI SAL YLHS KIVYRDLK EN++LD GH+ +TDFGLCKE
Sbjct: 236 HLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKE 295
Query: 311 GIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMY 370
GI + T TFCGTPEYLAPEV+ Y VDWW LG V+YEM+ G PFY +D +++
Sbjct: 296 GITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 355
Query: 371 DNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFESLSWADLVQ 429
+ IL + + +S A S+L LL KD RL G +D EI H FF ++W D+
Sbjct: 356 ELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYD 415
Query: 430 KKIPPPFNPNVAGPDDIRNFDTAFTEETV---PYSVCVSSD 467
KK+ PPF P V D R FD FT +T+ P C SD
Sbjct: 416 KKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKCQQSD 456
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 331 bits (848), Expect = 1e-90
Identities = 182/419 (43%), Positives = 246/419 (58%), Gaps = 23/419 (5%)
Query: 87 IKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSE---------DEDERSS 137
+K R N FI +++ + + +D+P+ + + +E E
Sbjct: 62 MKTERPKPNTFIIRCLQWTTV-----IERTFHVDTPEEREEWTEAIQAVADRLQRQEEER 116
Query: 138 QKLHSTSQNINLGP-----SGNPHAKPT--DFDFLKVIGKGSFGKVLLAKRKLDGKFYAV 190
TSQ N+G S H + T DFD+LK++GKG+FGKV+L + K GK+YA+
Sbjct: 117 MNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAM 176
Query: 191 KVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFF 250
K+L+K++++ + E H + E VL KN +HPFL L YSFQT ++L FV+++VNGGELFF
Sbjct: 177 KILKKEVIIAKDEVAHTLTESRVL-KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFF 235
Query: 251 HLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKE 310
HL RER F E R RFY AEI SAL YLHS KIVYRDLK EN++LD GH+ +TDFGLCKE
Sbjct: 236 HLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKE 295
Query: 311 GIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMY 370
GI + T TFCGTPEYLAPEV+ Y VDWW LG V+YEM+ G PFY +D +++
Sbjct: 296 GITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 355
Query: 371 DNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFESLSWADLVQ 429
+ IL + + +S A S+L LL KD RL G +D EI H FF ++W D+
Sbjct: 356 ELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYD 415
Query: 430 KKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYA 488
KK+ PPF P V D R FD FT +T+ + D ++ E F FSY+
Sbjct: 416 KKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYS 474
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 324 bits (830), Expect = 1e-88
Identities = 173/381 (45%), Positives = 240/381 (62%), Gaps = 9/381 (2%)
Query: 113 VRAFLQMDSPKHQSDPSED--EDERSSQKLHSTSQNINLGPSGNPHAKPT--DFDFLKVI 168
+RA + + Q P ED + + S ST++ + + S AK T DFD+LK++
Sbjct: 100 MRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVS-KARAKVTMNDFDYLKLL 158
Query: 169 GKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228
GKG+FGKV+L + K G++YA+K+L+K++++ + E H + E VL +N +HPFL L Y
Sbjct: 159 GKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL-QNTRHPFLTALKY 217
Query: 229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLK 288
+FQT ++L FV+++ NGGELFFHL RER F E RARFY AEI SAL YLHS +VYRD+K
Sbjct: 218 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIK 277
Query: 289 PENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLG 348
EN++LD GH+ +TDFGLCKEGI+ T TFCGTPEYLAPEV+ Y VDWW LG
Sbjct: 278 LENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLG 337
Query: 349 AVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAK 407
V+YEM+ G PFY +D +++ IL + + +S A S+L LL+KD + RL G
Sbjct: 338 VVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGP 397
Query: 408 EDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSD 467
D E+ H FF S++W D+VQKK+ PPF P V D R FD FT +++ ++
Sbjct: 398 SDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSI--TITPPDR 455
Query: 468 YSIVNASVLEADDAFVGFSYA 488
Y + L+ F FSY+
Sbjct: 456 YDSLGLLELDQRTHFPQFSYS 476
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 311 bits (797), Expect = 9e-85
Identities = 161/337 (47%), Positives = 214/337 (63%), Gaps = 9/337 (2%)
Query: 130 EDEDERSSQKLHSTSQNINLGPSGNPHAKP------TDFDFLKVIGKGSFGKVLLAKRKL 183
+ E+E + S S N AKP +F++LK++GKG+FGKV+L K K
Sbjct: 112 KQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA 171
Query: 184 DGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFV 243
G++YA+K+L+K++++ + E H + E VL +N +HPFL L YSFQT ++L FV+++
Sbjct: 172 TGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYA 230
Query: 244 NGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK-IVYRDLKPENILLDSVGHVVL 302
NGGELFFHL RER F E RARFY AEI SAL YLHS K +VYRDLK EN++LD GH+ +
Sbjct: 231 NGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290
Query: 303 TDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFY 362
TDFGLCKEGI T TFCGTPEYLAPEV+ Y VDWW LG V+YEM+ G PFY
Sbjct: 291 TDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 350
Query: 363 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFES 421
+D ++++ IL + + + A S+L LL+KD + RL G ED EI H FF
Sbjct: 351 NQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410
Query: 422 LSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETV 458
+ W + +KK+ PPF P V D R FD FT + +
Sbjct: 411 IVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMI 447
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 311 bits (797), Expect = 9e-85
Identities = 161/337 (47%), Positives = 214/337 (63%), Gaps = 9/337 (2%)
Query: 130 EDEDERSSQKLHSTSQNINLGPSGNPHAKP------TDFDFLKVIGKGSFGKVLLAKRKL 183
+ E+E + S S N AKP +F++LK++GKG+FGKV+L K K
Sbjct: 112 KQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA 171
Query: 184 DGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFV 243
G++YA+K+L+K++++ + E H + E VL +N +HPFL L YSFQT ++L FV+++
Sbjct: 172 TGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYA 230
Query: 244 NGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK-IVYRDLKPENILLDSVGHVVL 302
NGGELFFHL RER F E RARFY AEI SAL YLHS K +VYRDLK EN++LD GH+ +
Sbjct: 231 NGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290
Query: 303 TDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFY 362
TDFGLCKEGI T TFCGTPEYLAPEV+ Y VDWW LG V+YEM+ G PFY
Sbjct: 291 TDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 350
Query: 363 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFES 421
+D ++++ IL + + + A S+L LL+KD + RL G ED EI H FF
Sbjct: 351 NQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410
Query: 422 LSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETV 458
+ W + +KK+ PPF P V D R FD FT + +
Sbjct: 411 IVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMI 447
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 311 bits (797), Expect = 9e-85
Identities = 161/337 (47%), Positives = 214/337 (63%), Gaps = 9/337 (2%)
Query: 130 EDEDERSSQKLHSTSQNINLGPSGNPHAKP------TDFDFLKVIGKGSFGKVLLAKRKL 183
+ E+E + S S N AKP +F++LK++GKG+FGKV+L K K
Sbjct: 112 KQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA 171
Query: 184 DGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFV 243
G++YA+K+L+K++++ + E H + E VL +N +HPFL L YSFQT ++L FV+++
Sbjct: 172 TGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNSRHPFLTALKYSFQTHDRLCFVMEYA 230
Query: 244 NGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK-IVYRDLKPENILLDSVGHVVL 302
NGGELFFHL RER F E RARFY AEI SAL YLHS K +VYRDLK EN++LD GH+ +
Sbjct: 231 NGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKI 290
Query: 303 TDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFY 362
TDFGLCKEGI T TFCGTPEYLAPEV+ Y VDWW LG V+YEM+ G PFY
Sbjct: 291 TDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFY 350
Query: 363 CRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFES 421
+D ++++ IL + + + A S+L LL+KD + RL G ED EI H FF
Sbjct: 351 NQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAG 410
Query: 422 LSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETV 458
+ W + +KK+ PPF P V D R FD FT + +
Sbjct: 411 IVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMI 447
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 304 bits (779), Expect = 1e-82
Identities = 163/396 (41%), Positives = 233/396 (58%), Gaps = 31/396 (7%)
Query: 117 LQMDSPKHQSD------PSEDEDERSSQKLHSTSQNINLGPSGNPHAKP--TDFDFLKVI 168
+ MD SD P S ++ + +N SG + DFD L+VI
Sbjct: 201 MPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVI 260
Query: 169 GKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228
G+GS+ KVLL + K + YA+KV++K++V + ++ + E++V + HPFLVGLH
Sbjct: 261 GRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHS 320
Query: 229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLK 288
FQT +L+FV+++VNGG+L FH+QR+R PE ARFY+AEI+ AL YLH I+YRDLK
Sbjct: 321 CFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLK 380
Query: 289 PENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLG 348
+N+LLDS GH+ LTD+G+CKEG+ DTT+TFCGTP Y+APE++R + Y +VDWW LG
Sbjct: 381 LDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALG 440
Query: 349 AVLYEMLYGLPPFYCRDVAEMYDN------------ILHKPLSLRPGVSLTAWSILEELL 396
+++EM+ G PF D+ DN IL K + + +S+ A S+L+ L
Sbjct: 441 VLMFEMMAGRSPF---DIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFL 497
Query: 397 EKDRQNRLGA--KEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFT 454
KD + RLG + F +IQ HPFF ++ W + QK++ PPF PN++G + NFD+ FT
Sbjct: 498 NKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFT 557
Query: 455 EETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490
E V + D IV F GF Y P
Sbjct: 558 NEPVQLT---PDDDDIVRKI---DQSEFEGFEYINP 587
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 299 bits (765), Expect = 4e-81
Identities = 162/360 (45%), Positives = 231/360 (64%), Gaps = 18/360 (5%)
Query: 138 QKLHSTSQNINLGPSG-NPHAKPTDFDFLKVIGKGSFGKVLLAKRKLD---GKFYAVKVL 193
+++ T ++N+GP PH F+ L+V+GKG +GKV ++ GK YA+KVL
Sbjct: 46 EEVELTETSVNVGPERIGPHC----FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVL 101
Query: 194 QK-KIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHL 252
+K KIV N K+ H AERN+L ++VKHPF+V L Y+FQT KLY +L+ ++GGELF HL
Sbjct: 102 RKAKIVRNAKDTAHTRAERNIL-ESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHL 160
Query: 253 QRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGI 312
+RE F E A FY AEI ALG+LHS I+YRDLKPENI+L S GH+ LTDFGLCKE I
Sbjct: 161 EREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI 220
Query: 313 AISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDN 372
T TFCGT EY+APE++ + ++ VDWW LGA++Y+ML G PPF + + D
Sbjct: 221 HEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDK 280
Query: 373 ILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFESLSWADLVQKK 431
I+ L+L P ++ A ++++ L+++ R+ G D ++Q HPFF ++W DL+ +
Sbjct: 281 IIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWR 340
Query: 432 IPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPS 491
+ PPF P + +D+ FDT FT +T P S D + ++ S A+ AF+GF+Y PS
Sbjct: 341 VDPPFRPCLQSEEDVSQFDTRFTRQT-PVD---SPDDTALSES---ANQAFLGFTYVAPS 393
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 298 bits (763), Expect = 8e-81
Identities = 162/359 (45%), Positives = 230/359 (64%), Gaps = 16/359 (4%)
Query: 138 QKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLD---GKFYAVKVLQ 194
+K + ++N GP +P F+ L+V+GKG +GKV ++ GK +A+KVL+
Sbjct: 70 EKFEISETSVNRGPE---KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLK 126
Query: 195 KK-IVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQ 253
K IV N K+ H AERN+L + VKHPF+V L Y+FQT KLY +L++++GGELF L+
Sbjct: 127 KAMIVRNAKDTAHTKAERNIL-EEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLE 185
Query: 254 RERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIA 313
RE F E A FY AEI+ ALG+LH I+YRDLKPENI+L+ GHV LTDFGLCKE I
Sbjct: 186 REGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIH 245
Query: 314 ISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNI 373
T TFCGT EY+APE++ + ++ VDWW LGA++Y+ML G PPF + + D I
Sbjct: 246 DGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKI 305
Query: 374 LHKPLSLRPGVSLTAWSILEELLEKDRQNRLGA-KEDFLEIQNHPFFESLSWADLVQKKI 432
L L+L P ++ A +L++LL+++ +RLGA D E+Q HPFF ++W +L+ +K+
Sbjct: 306 LKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKV 365
Query: 433 PPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPS 491
PPF P + +D+ FD+ FT +T P S D S ++ S A+ F+GF+Y PS
Sbjct: 366 EPPFKPLLQSEEDVSQFDSKFTRQT-PVD---SPDDSTLSES---ANQVFLGFTYVAPS 417
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 295 bits (755), Expect = 6e-80
Identities = 148/330 (44%), Positives = 212/330 (64%), Gaps = 9/330 (2%)
Query: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
+F+F+KV+GKGSFGKV+LA+ K + YAVKVL+K ++L + M E+ +L KH
Sbjct: 407 EFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKH 466
Query: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
P+L L+ FQT ++L+FV+++VNGG+L F +QR R F E R+RFYAAE+ SAL +LH
Sbjct: 467 PYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQH 526
Query: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340
++YRDLK +NILLD+ GH L DFG+CKEGI TTTTFCGTP+Y+APE++++ Y
Sbjct: 527 GVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGP 586
Query: 341 TVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDR 400
+VDWW LG ++YEM+ G PPF + +++++ILH + +S A SIL+ + K+
Sbjct: 587 SVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNP 646
Query: 401 QNRLG---AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEET 457
RLG ++ I+ HPFF+ + W L QKKI PPF P + D+ NFD FT E
Sbjct: 647 HKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREE 706
Query: 458 VPYSVCVSSDYSIVNASVLEADDAFVGFSY 487
++ + +N + F GFSY
Sbjct: 707 PVLTLVDEAIVKQIN------QEEFKGFSY 730
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 291 bits (745), Expect = 9e-79
Identities = 159/391 (40%), Positives = 226/391 (57%), Gaps = 24/391 (6%)
Query: 117 LQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKP----------------T 160
L + ++ + P + DE + +L + LGP+GN P T
Sbjct: 278 LNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLT 337
Query: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
DF+FL V+GKGSFGKV+LA RK + YA+K+L+K +V+ + + M E+ VL K
Sbjct: 338 DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKP 397
Query: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
PFL LH FQT ++LYFV+++VNGG+L +H+Q+ F E +A FYAAEI+ L +LH
Sbjct: 398 PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKR 457
Query: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340
I+YRDLK +N++LDS GH+ + DFG+CKE + TT TFCGTP+Y+APE+I QPY
Sbjct: 458 GIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGK 517
Query: 341 TVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDR 400
+VDWW G +LYEML G PPF D E++ +I+ +S +S A SI + L+ K
Sbjct: 518 SVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHP 577
Query: 401 QNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVP 459
RLG E +++ H FF + W L ++I PPF P V G NFD FT
Sbjct: 578 AKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCG-KGAENFDKFFTRG--- 633
Query: 460 YSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490
++ +V A++ ++D F GFSY P
Sbjct: 634 -QPVLTPPDQLVIANIDQSD--FEGFSYVNP 661
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 288 bits (736), Expect = 1e-77
Identities = 149/355 (41%), Positives = 212/355 (59%), Gaps = 8/355 (2%)
Query: 138 QKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKI 197
Q S+ + +G + + +F+F++V+GKGSFGKV+LA+ K G YAVKVL+K +
Sbjct: 331 QGKESSKEGNGIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDV 390
Query: 198 VLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERS 257
+L + + M E+ +L HPFL L FQT ++L+FV++FVNGG+L FH+Q+ R
Sbjct: 391 ILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRR 450
Query: 258 FPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDT 317
F E RARFYAAEI SAL +LH I+YRDLK +N+LLD GH L DFG+CKEGI T
Sbjct: 451 FDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVT 510
Query: 318 TTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKP 377
T TFCGTP+Y+APE++++ Y VDWW +G +LYEML G PF + ++++ IL+
Sbjct: 511 TATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDE 570
Query: 378 LSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLE--IQNHPFFESLSWADLVQKKIPPP 435
+ + A IL+ + K+ RLG+ E I HPFF+ + WA L ++I PP
Sbjct: 571 VVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPP 630
Query: 436 FNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490
F P + +D+ NFD F +E + ++N D F FSY P
Sbjct: 631 FRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMIN------QDEFRNFSYVSP 679
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 288 bits (736), Expect = 1e-77
Identities = 147/339 (43%), Positives = 215/339 (63%), Gaps = 15/339 (4%)
Query: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
DFD ++VIG+GS+ KVLL + K + + YA+KV++K++V + ++ + E++V + +
Sbjct: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
Query: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
PFLVGLH FQTT +L+ V+++VNGG+L FH+QR+R PE ARFYAAEI AL +LH
Sbjct: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
Query: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340
I+YRDLK +N+LLD+ GH+ LTD+G+CKEG+ DTT+TFCGTP Y+APE++R + Y
Sbjct: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
Query: 341 TVDWWCLGAVLYEMLYGLPPF-YCRDVAEM------YDNILHKPLSLRPGVSLTAWSILE 393
+VDWW LG +++EM+ G PF D +M + IL KP+ + +S+ A +L+
Sbjct: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
Query: 394 ELLEKDRQNRLGAKED--FLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDT 451
L KD + RLG + F +I++H FF S+ W L +K+ PPF P + + NFDT
Sbjct: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
Query: 452 AFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490
FT E P + + +I E F GF Y P
Sbjct: 368 QFTSE--PVQLTPDDEDAIKRIDQSE----FEGFEYINP 400
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 288 bits (736), Expect = 1e-77
Identities = 147/339 (43%), Positives = 215/339 (63%), Gaps = 15/339 (4%)
Query: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
DFD ++VIG+GS+ KVLL + K + + YA+KV++K++V + ++ + E++V + +
Sbjct: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
Query: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
PFLVGLH FQTT +L+ V+++VNGG+L FH+QR+R PE ARFYAAEI AL +LH
Sbjct: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
Query: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340
I+YRDLK +N+LLD+ GH+ LTD+G+CKEG+ DTT+TFCGTP Y+APE++R + Y
Sbjct: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
Query: 341 TVDWWCLGAVLYEMLYGLPPF-YCRDVAEM------YDNILHKPLSLRPGVSLTAWSILE 393
+VDWW LG +++EM+ G PF D +M + IL KP+ + +S+ A +L+
Sbjct: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
Query: 394 ELLEKDRQNRLGAKED--FLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDT 451
L KD + RLG + F +I++H FF S+ W L +K+ PPF P + + NFDT
Sbjct: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
Query: 452 AFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490
FT E P + + +I E F GF Y P
Sbjct: 368 QFTSE--PVQLTPDDEDAIKRIDQSE----FEGFEYINP 400
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 288 bits (736), Expect = 1e-77
Identities = 147/339 (43%), Positives = 215/339 (63%), Gaps = 15/339 (4%)
Query: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
DFD ++VIG+GS+ KVLL + K + + YA+KV++K++V + ++ + E++V + +
Sbjct: 251 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 310
Query: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
PFLVGLH FQTT +L+ V+++VNGG+L FH+QR+R PE ARFYAAEI AL +LH
Sbjct: 311 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 370
Query: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340
I+YRDLK +N+LLD+ GH+ LTD+G+CKEG+ DTT+TFCGTP Y+APE++R + Y
Sbjct: 371 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 430
Query: 341 TVDWWCLGAVLYEMLYGLPPF-YCRDVAEM------YDNILHKPLSLRPGVSLTAWSILE 393
+VDWW LG +++EM+ G PF D +M + IL KP+ + +S+ A +L+
Sbjct: 431 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 490
Query: 394 ELLEKDRQNRLGAKED--FLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDT 451
L KD + RLG + F +I++H FF S+ W L +K+ PPF P + + NFDT
Sbjct: 491 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 550
Query: 452 AFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490
FT E P + + +I E F GF Y P
Sbjct: 551 QFTSE--PVQLTPDDEDAIKRIDQSE----FEGFEYINP 583
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 281 bits (720), Expect = 7e-76
Identities = 148/334 (44%), Positives = 204/334 (61%), Gaps = 7/334 (2%)
Query: 158 KPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKN 217
K TDF+FL V+GKGSFGKV+L++RK + YAVK+L+K +V+ + + M E+ VL
Sbjct: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397
Query: 218 VKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYL 277
K PFL LH FQT ++LYFV+++VNGG+L +H+Q+ F E A FYAAEIA L +L
Sbjct: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457
Query: 278 HSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQP 337
S I+YRDLK +N++LDS GH+ + DFG+CKE I TT TFCGTP+Y+APE+I QP
Sbjct: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517
Query: 338 YDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLE 397
Y +VDWW G +LYEML G PF D E++ +I+ ++ +S A +I + L+
Sbjct: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577
Query: 398 KDRQNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEE 456
K RLG E +I+ H FF + W L +K+I PP+ P D NFD FT +
Sbjct: 578 KHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQ 637
Query: 457 TVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490
P + + I+N + F GFSY P
Sbjct: 638 --PVELTPTDKLFIMNLD----QNEFAGFSYTNP 665
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 274 bits (700), Expect = 2e-73
Identities = 151/340 (44%), Positives = 205/340 (60%), Gaps = 10/340 (2%)
Query: 122 PKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK- 180
P S P D DE +++ T +G+ A P+ F+ LKV+G+GSFGKV L +
Sbjct: 35 PGPGSGPQRDSDEGVLKEISITHHV----KAGSEKADPSHFELLKVLGQGSFGKVFLVRK 90
Query: 181 --RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYF 238
R G YA+KVL KK L +++ ER++L +V HPF+V LHY+FQT KLY
Sbjct: 91 VTRPDSGHLYAMKVL-KKATLKVRDRVRTKMERDILA-DVNHPFVVKLHYAFQTEGKLYL 148
Query: 239 VLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVG 298
+LDF+ GG+LF L +E F E +FY AE+A L +LHS+ I+YRDLKPENILLD G
Sbjct: 149 ILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEG 208
Query: 299 HVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGL 358
H+ LTDFGL KE I +FCGT EY+APEV+ +Q + ++ DWW G +++EML G
Sbjct: 209 HIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGS 268
Query: 359 PPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFL-EIQNHP 417
PF +D E IL L + +S A S+L L +++ NRLG+ D EI+ H
Sbjct: 269 LPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV 328
Query: 418 FFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEET 457
F+ ++ W L +++I PPF P VA PDD FDT FT T
Sbjct: 329 FYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRT 368
Score = 119 bits (298), Expect = 6e-27
Identities = 86/265 (32%), Positives = 132/265 (49%), Gaps = 24/265 (9%)
Query: 166 KVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVG 225
+ IG GS+ + K YAVKV+ K ++ E +LL+ +HP ++
Sbjct: 431 ETIGVGSYSECKRCVHKATNMEYAVKVIDKS-------KRDPSEEIEILLRYGQHPNIIT 483
Query: 226 LHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYR 285
L + + +Y V + + GGEL + R++ F E A F I + YLHS +V+R
Sbjct: 484 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 543
Query: 286 DLKPENIL-LDSVGH---VVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNT 341
DLKP NIL +D G+ + + DFG K+ A + T C T ++APEV+++Q YD
Sbjct: 544 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEG 603
Query: 342 VDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHK----PLSLRPG----VSLTAWSILE 393
D W LG +LY ML G PF ++ + IL + +L G VS TA ++
Sbjct: 604 CDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVS 662
Query: 394 ELLEKDRQNRLGAKEDFLEIQNHPF 418
++L D RL AK ++ HP+
Sbjct: 663 KMLHVDPHQRLTAK----QVLQHPW 683
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 271 bits (693), Expect = 1e-72
Identities = 139/298 (46%), Positives = 191/298 (64%), Gaps = 2/298 (0%)
Query: 158 KPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKN 217
K TDF+FL V+GKGSFGKV+L++RK + YAVK+L+K +V+ + + M E+ VL
Sbjct: 338 KLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 397
Query: 218 VKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYL 277
K PFL LH FQT ++LYFV+++VNGG+L +H+Q+ F E A FYAAEIA L +L
Sbjct: 398 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 457
Query: 278 HSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQP 337
S I+YRDLK +N++LDS GH+ + DFG+CKE I TT TFCGTP+Y+APE+I QP
Sbjct: 458 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQP 517
Query: 338 YDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLE 397
Y +VDWW G +LYEML G PF D E++ +I+ ++ +S A +I + L+
Sbjct: 518 YGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577
Query: 398 KDRQNRLG-AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFT 454
K RLG E +I+ H FF + W L +K+I PP+ P G + NFD FT
Sbjct: 578 KHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACG-RNAENFDRFFT 634
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 271 bits (692), Expect = 1e-72
Identities = 144/310 (46%), Positives = 195/310 (62%), Gaps = 6/310 (1%)
Query: 152 SGNPHAKPTDFDFLKVIGKGSFGKVLLAK---RKLDGKFYAVKVLQKKIVLNRKEQKHIM 208
+G+ A P+ F+ LKV+G+GSFGKV L + R G YA+KVL KK L +++
Sbjct: 52 AGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVL-KKATLKVRDRVRTK 110
Query: 209 AERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAA 268
ER++L +V HPF+V LHY+FQT KLY +LDF+ GG+LF L +E F E +FY A
Sbjct: 111 MERDILA-DVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLA 169
Query: 269 EIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYL 328
E+A L +LHS+ I+YRDLKPENILLD GH+ LTDFGL KE I +FCGT EY+
Sbjct: 170 ELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYM 229
Query: 329 APEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTA 388
APEV+ +Q + ++ DWW G +++EML G PF +D E IL L + +S A
Sbjct: 230 APEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEA 289
Query: 389 WSILEELLEKDRQNRLGAKEDFL-EIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIR 447
S+L L +++ NRLG+ D EI+ H F+ ++ W L +++I PPF P VA PDD
Sbjct: 290 QSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTF 349
Query: 448 NFDTAFTEET 457
FDT FT T
Sbjct: 350 YFDTEFTSRT 359
Score = 119 bits (298), Expect = 6e-27
Identities = 86/265 (32%), Positives = 132/265 (49%), Gaps = 24/265 (9%)
Query: 166 KVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVG 225
+ IG GS+ + K YAVKV+ K ++ E +LL+ +HP ++
Sbjct: 422 ETIGVGSYSECKRCVHKATNMEYAVKVIDKS-------KRDPSEEIEILLRYGQHPNIIT 474
Query: 226 LHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYR 285
L + + +Y V + + GGEL + R++ F E A F I + YLHS +V+R
Sbjct: 475 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 534
Query: 286 DLKPENIL-LDSVGH---VVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNT 341
DLKP NIL +D G+ + + DFG K+ A + T C T ++APEV+++Q YD
Sbjct: 535 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEG 594
Query: 342 VDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHK----PLSLRPG----VSLTAWSILE 393
D W LG +LY ML G PF ++ + IL + +L G VS TA ++
Sbjct: 595 CDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVS 653
Query: 394 ELLEKDRQNRLGAKEDFLEIQNHPF 418
++L D RL AK ++ HP+
Sbjct: 654 KMLHVDPHQRLTAK----QVLQHPW 674
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 270 bits (689), Expect = 3e-72
Identities = 156/380 (41%), Positives = 219/380 (57%), Gaps = 20/380 (5%)
Query: 119 MDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLL 178
MD P + + + +E S +++ T G+ A P+ F+ LKV+G+GSFGKV L
Sbjct: 29 MDEPMGEEEINPQTEEVSIKEIAITHHV----KEGHEKADPSQFELLKVLGQGSFGKVFL 84
Query: 179 AKRKLDG----KFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTE 234
K K+ G + YA+KVL KK L +++ ER++L++ V HPF+V LHY+FQT
Sbjct: 85 VK-KISGSDARQLYAMKVL-KKATLKVRDRVRTKMERDILVE-VNHPFIVKLHYAFQTEG 141
Query: 235 KLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILL 294
KLY +LDF+ GG+LF L +E F E +FY AE+A AL +LHS+ I+YRDLKPENILL
Sbjct: 142 KLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILL 201
Query: 295 DSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEM 354
D GH+ LTDFGL KE I +FCGT EY+APEV+ ++ + + DWW G +++EM
Sbjct: 202 DEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEM 261
Query: 355 LYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFL-EI 413
L G PF +D E IL L + +S A S+L L +++ NRLGA D + EI
Sbjct: 262 LTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEI 321
Query: 414 QNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNA 473
+ H FF ++ W L +++I PPF P P+D FD FT +T S +
Sbjct: 322 KRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPS------ 375
Query: 474 SVLEADDAFVGFSYAPPSED 493
A F GFS+ + D
Sbjct: 376 --ANAHQLFRGFSFVAITSD 393
Score = 108 bits (270), Expect = 1e-23
Identities = 85/277 (30%), Positives = 132/277 (47%), Gaps = 26/277 (9%)
Query: 168 IGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLH 227
IG GS+ K +AVK++ K ++ E +LL+ +HP ++ L
Sbjct: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKS-------KRDPTEEIEILLRYGQHPNIITLK 480
Query: 228 YSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDL 287
+ + +Y V + + GGEL + R++ F E A I + YLH+ +V+RDL
Sbjct: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540
Query: 288 KPENIL-LDSVGH---VVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVD 343
KP NIL +D G+ + + DFG K+ A + T C T ++APEV+++Q YD D
Sbjct: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD 600
Query: 344 WWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHK----PLSLRPG----VSLTAWSILEEL 395
W LG +LY ML G PF + + IL + SL G VS TA ++ ++
Sbjct: 601 IWSLGVLLYTMLTGYTPF-ANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKM 659
Query: 396 LEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKI 432
L D RL A + HP+ + W L Q ++
Sbjct: 660 LHVDPHQRLTA----ALVLRHPWI--VHWDQLPQYQL 690
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 269 bits (687), Expect = 5e-72
Identities = 154/383 (40%), Positives = 218/383 (56%), Gaps = 18/383 (4%)
Query: 112 DVRAFLQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKG 171
+V +D P + + DE +++ T G A P F+ LKV+G+G
Sbjct: 27 EVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHHV----KEGYEKADPAQFELLKVLGQG 82
Query: 172 SFGKVLLAKRKLD---GKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228
SFGKV L ++K G+ YA+KVL KK L +++ ER++L++ V HPF+V LHY
Sbjct: 83 SFGKVFLVRKKTGPDAGQLYAMKVL-KKASLKVRDRVRTKMERDILVE-VNHPFIVKLHY 140
Query: 229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLK 288
+FQT KLY +LDF+ GG++F L +E F E +FY AE+A AL +LH + IVYRDLK
Sbjct: 141 AFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLK 200
Query: 289 PENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLG 348
PENILLD +GH+ LTDFGL KE + +FCGT EY+APEV+ ++ + + DWW G
Sbjct: 201 PENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYG 260
Query: 349 AVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKE 408
+++EML G PF +D E + IL L + +S A S+L L +++ NRLG+ E
Sbjct: 261 VLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGS-E 319
Query: 409 DFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDY 468
EI+ H FF ++ W L ++++ PPF P PDD FD FT +T D
Sbjct: 320 GVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKT-------PKDS 372
Query: 469 SIVNASVLEADDAFVGFSYAPPS 491
+ AS A F GFS+ S
Sbjct: 373 PGLPASA-NAHQLFKGFSFVATS 394
Score = 99.8 bits (247), Expect = 5e-21
Identities = 62/204 (30%), Positives = 96/204 (47%), Gaps = 11/204 (5%)
Query: 162 FDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHP 221
++ + IG GS+ +AVK++ K ++ E +L++ +HP
Sbjct: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKS-------KRDPSEEIEILMRYGQHP 478
Query: 222 FLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK 281
++ L F +Y V D + GGEL + +++ F E A I+ + YLH
Sbjct: 479 NIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQG 538
Query: 282 IVYRDLKPENILL----DSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQP 337
+V+RDLKP NIL S + + DFG K+ + T C T ++APEV+ +Q
Sbjct: 539 VVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQG 598
Query: 338 YDNTVDWWCLGAVLYEMLYGLPPF 361
YD D W LG + Y ML G PF
Sbjct: 599 YDAACDIWSLGVLFYTMLAGYTPF 622
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,108,974
Number of Sequences: 37866
Number of extensions: 914304
Number of successful extensions: 4523
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 728
Number of HSP's successfully gapped in prelim test: 103
Number of HSP's that attempted gapping in prelim test: 2187
Number of HSP's gapped (non-prelim): 1016
length of query: 496
length of database: 18,247,518
effective HSP length: 106
effective length of query: 390
effective length of database: 14,233,722
effective search space: 5551151580
effective search space used: 5551151580
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.