Guide to the Human Genome
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Search of human proteins with 31083315

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|31083315 G protein-coupled receptor 45 [Homo sapiens]
         (372 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|31083315 G protein-coupled receptor 45 [Homo sapiens]              742   0.0  
gi|221139879 G protein-coupled receptor 63 [Homo sapiens]             404   e-113
gi|13540557 G protein-coupled receptor 63 [Homo sapiens]              404   e-113
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]         118   1e-26
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]         118   1e-26
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]         118   1e-26
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]         118   1e-26
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]         118   1e-26
gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]         118   1e-26
gi|157426873 tachykinin receptor 2 [Homo sapiens]                     117   2e-26
gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens]        112   4e-25
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]    110   3e-24
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]    110   3e-24
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]    110   3e-24
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]    110   3e-24
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]   109   3e-24
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]   109   3e-24
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]    109   3e-24
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]      107   2e-23
gi|62865887 G protein-coupled receptor 54 [Homo sapiens]              106   3e-23
gi|4507343 tachykinin receptor 1 isoform long [Homo sapiens]          103   2e-22
gi|4505445 neuropeptide Y receptor Y1 [Homo sapiens]                  102   4e-22
gi|7669546 tachykinin receptor 1 isoform short [Homo sapiens]         102   7e-22
gi|7669548 tachykinin receptor 3 [Homo sapiens]                       102   7e-22
gi|4503383 dopamine receptor D1 [Homo sapiens]                        101   9e-22
gi|4758474 G protein-coupled receptor 10 [Homo sapiens]               100   2e-21
gi|11545887 neuropeptide FF receptor 1 [Homo sapiens]                  99   5e-21
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]                 99   6e-21
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]            99   8e-21
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]             99   8e-21

>gi|31083315 G protein-coupled receptor 45 [Homo sapiens]
          Length = 372

 Score =  742 bits (1915), Expect = 0.0
 Identities = 372/372 (100%), Positives = 372/372 (100%)

Query: 1   MACNSTSLEAYTYLLLNTSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVY 60
           MACNSTSLEAYTYLLLNTSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVY
Sbjct: 1   MACNSTSLEAYTYLLLNTSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVY 60

Query: 61  QRPAMRSAINLLLATLAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLE 120
           QRPAMRSAINLLLATLAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLE
Sbjct: 61  QRPAMRSAINLLLATLAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLE 120

Query: 121 GVAILLIISVDRFLIIVQRQDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAP 180
           GVAILLIISVDRFLIIVQRQDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAP
Sbjct: 121 GVAILLIISVDRFLIIVQRQDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAP 180

Query: 181 QCVLGYTELPADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQ 240
           QCVLGYTELPADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQ
Sbjct: 181 QCVLGYTELPADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQ 240

Query: 241 LTRAGLRRLQRQQQVSVDLSFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGS 300
           LTRAGLRRLQRQQQVSVDLSFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGS
Sbjct: 241 LTRAGLRRLQRQQQVSVDLSFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGS 300

Query: 301 SFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREACIELLPQTFQILPKVPERIRRRIQPS 360
           SFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREACIELLPQTFQILPKVPERIRRRIQPS
Sbjct: 301 SFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREACIELLPQTFQILPKVPERIRRRIQPS 360

Query: 361 TVYVCNENQSAV 372
           TVYVCNENQSAV
Sbjct: 361 TVYVCNENQSAV 372


>gi|221139879 G protein-coupled receptor 63 [Homo sapiens]
          Length = 419

 Score =  404 bits (1039), Expect = e-113
 Identities = 190/344 (55%), Positives = 262/344 (76%)

Query: 29  LPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLATLAFSDIMLSLCCM 88
           L  PL+I+L+ +M+ +  V FLGN VVC++VYQ+ AMRSAIN+LLA+LAF+D++L++  M
Sbjct: 76  LNLPLQITLSAIMIFILFVSFLGNLVVCLMVYQKAAMRSAINILLASLAFADMLLAVLNM 135

Query: 89  PFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLIIVQRQDKLNPRRA 148
           PF  VT++T RW FG  FCR+SA  +W FV+EGVAILLIIS+DRFLIIVQRQDKLNP RA
Sbjct: 136 PFALVTILTTRWIFGKFFCRVSAMFFWLFVIEGVAILLIISIDRFLIIVQRQDKLNPYRA 195

Query: 149 KVIIAVSWVLSFCIAGPSLTGWTLVEVPARAPQCVLGYTELPADRAYVVTLVVAVFFAPF 208
           KV+IAVSW  SFC+A P   G   +++P+RAPQCV GYT  P  +AYV+ + +  FF PF
Sbjct: 196 KVLIAVSWATSFCVAFPLAVGNPDLQIPSRAPQCVFGYTTNPGYQAYVILISLISFFIPF 255

Query: 209 GVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLTRAGLRRLQRQQQVSVDLSFKTKAFTT 268
            V+L ++M ILNT+R NA+R+H+  + + L Q ++ GL  LQR  Q+S+D+ FKT+AFTT
Sbjct: 256 LVILYSFMGILNTLRHNALRIHSYPEGICLSQASKLGLMSLQRPFQMSIDMGFKTRAFTT 315

Query: 269 ILILFVGFSLCWLPHSVYSLLSVFSQRFYCGSSFYATSTCVLWLSYLKSVFNPIVYCWRI 328
           ILILF  F +CW P + YSL++ FS+ FY   +F+  ST +LWL YLKS  NP++Y WRI
Sbjct: 316 ILILFAVFIVCWAPFTTYSLVATFSKHFYYQHNFFEISTWLLWLCYLKSALNPLIYYWRI 375

Query: 329 KKFREACIELLPQTFQILPKVPERIRRRIQPSTVYVCNENQSAV 372
           KKF +AC++++P++F+ LP++P   +RRI+PS VYVC E+++ V
Sbjct: 376 KKFHDACLDMMPKSFKFLPQLPGHTKRRIRPSAVYVCGEHRTVV 419


>gi|13540557 G protein-coupled receptor 63 [Homo sapiens]
          Length = 419

 Score =  404 bits (1039), Expect = e-113
 Identities = 190/344 (55%), Positives = 262/344 (76%)

Query: 29  LPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLATLAFSDIMLSLCCM 88
           L  PL+I+L+ +M+ +  V FLGN VVC++VYQ+ AMRSAIN+LLA+LAF+D++L++  M
Sbjct: 76  LNLPLQITLSAIMIFILFVSFLGNLVVCLMVYQKAAMRSAINILLASLAFADMLLAVLNM 135

Query: 89  PFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLIIVQRQDKLNPRRA 148
           PF  VT++T RW FG  FCR+SA  +W FV+EGVAILLIIS+DRFLIIVQRQDKLNP RA
Sbjct: 136 PFALVTILTTRWIFGKFFCRVSAMFFWLFVIEGVAILLIISIDRFLIIVQRQDKLNPYRA 195

Query: 149 KVIIAVSWVLSFCIAGPSLTGWTLVEVPARAPQCVLGYTELPADRAYVVTLVVAVFFAPF 208
           KV+IAVSW  SFC+A P   G   +++P+RAPQCV GYT  P  +AYV+ + +  FF PF
Sbjct: 196 KVLIAVSWATSFCVAFPLAVGNPDLQIPSRAPQCVFGYTTNPGYQAYVILISLISFFIPF 255

Query: 209 GVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLTRAGLRRLQRQQQVSVDLSFKTKAFTT 268
            V+L ++M ILNT+R NA+R+H+  + + L Q ++ GL  LQR  Q+S+D+ FKT+AFTT
Sbjct: 256 LVILYSFMGILNTLRHNALRIHSYPEGICLSQASKLGLMSLQRPFQMSIDMGFKTRAFTT 315

Query: 269 ILILFVGFSLCWLPHSVYSLLSVFSQRFYCGSSFYATSTCVLWLSYLKSVFNPIVYCWRI 328
           ILILF  F +CW P + YSL++ FS+ FY   +F+  ST +LWL YLKS  NP++Y WRI
Sbjct: 316 ILILFAVFIVCWAPFTTYSLVATFSKHFYYQHNFFEISTWLLWLCYLKSALNPLIYYWRI 375

Query: 329 KKFREACIELLPQTFQILPKVPERIRRRIQPSTVYVCNENQSAV 372
           KKF +AC++++P++F+ LP++P   +RRI+PS VYVC E+++ V
Sbjct: 376 KKFHDACLDMMPKSFKFLPQLPGHTKRRIRPSAVYVCGEHRTVV 419


>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
          Length = 359

 Score =  118 bits (295), Expect = 1e-26
 Identities = 88/339 (25%), Positives = 156/339 (46%), Gaps = 30/339 (8%)

Query: 16  LNTSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLAT 75
           L+ + +S+ G   +   + ++    ++LM ++G L   V+  + + R   +   N  + +
Sbjct: 4   LDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNL--LVMVAVCWDRQLRKIKTNYFIVS 61

Query: 76  LAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLI 135
           LAF+D+++S+  MPF A+ L+   W +G+ FC +  +L        +  L  IS+DR+  
Sbjct: 62  LAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYA 121

Query: 136 I----VQRQDKLNPRRAKVIIAVSWVL-SFCIAGPSLTGWT------LVEVPARAPQCVL 184
           I    +  ++K+ P R  +++   WV+ +F    P + GW       L+E          
Sbjct: 122 ICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNS 181

Query: 185 GYTELPADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLTRA 244
            Y     ++ Y +T  V  F+ PF +M+ AY  I  T +++A ++         + L RA
Sbjct: 182 TYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQI---------QMLQRA 232

Query: 245 GLRRLQRQQQVSVD----LSFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGS 300
           G     R Q         +  +TKA  T+ I+   F LCW P  V +++  F      G 
Sbjct: 233 GASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQ 292

Query: 301 SFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREACIELL 339
            +    T  LWL Y+ S  NP +Y +  K FR A + +L
Sbjct: 293 VW----TAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL 327


>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
          Length = 428

 Score =  118 bits (295), Expect = 1e-26
 Identities = 88/339 (25%), Positives = 156/339 (46%), Gaps = 30/339 (8%)

Query: 16  LNTSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLAT 75
           L+ + +S+ G   +   + ++    ++LM ++G L   V+  + + R   +   N  + +
Sbjct: 4   LDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNL--LVMVAVCWDRQLRKIKTNYFIVS 61

Query: 76  LAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLI 135
           LAF+D+++S+  MPF A+ L+   W +G+ FC +  +L        +  L  IS+DR+  
Sbjct: 62  LAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYA 121

Query: 136 I----VQRQDKLNPRRAKVIIAVSWVL-SFCIAGPSLTGWT------LVEVPARAPQCVL 184
           I    +  ++K+ P R  +++   WV+ +F    P + GW       L+E          
Sbjct: 122 ICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNS 181

Query: 185 GYTELPADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLTRA 244
            Y     ++ Y +T  V  F+ PF +M+ AY  I  T +++A ++         + L RA
Sbjct: 182 TYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQI---------QMLQRA 232

Query: 245 GLRRLQRQQQVSVD----LSFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGS 300
           G     R Q         +  +TKA  T+ I+   F LCW P  V +++  F      G 
Sbjct: 233 GASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQ 292

Query: 301 SFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREACIELL 339
            +    T  LWL Y+ S  NP +Y +  K FR A + +L
Sbjct: 293 VW----TAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL 327


>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
          Length = 360

 Score =  118 bits (295), Expect = 1e-26
 Identities = 88/339 (25%), Positives = 156/339 (46%), Gaps = 30/339 (8%)

Query: 16  LNTSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLAT 75
           L+ + +S+ G   +   + ++    ++LM ++G L   V+  + + R   +   N  + +
Sbjct: 4   LDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNL--LVMVAVCWDRQLRKIKTNYFIVS 61

Query: 76  LAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLI 135
           LAF+D+++S+  MPF A+ L+   W +G+ FC +  +L        +  L  IS+DR+  
Sbjct: 62  LAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYA 121

Query: 136 I----VQRQDKLNPRRAKVIIAVSWVL-SFCIAGPSLTGWT------LVEVPARAPQCVL 184
           I    +  ++K+ P R  +++   WV+ +F    P + GW       L+E          
Sbjct: 122 ICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNS 181

Query: 185 GYTELPADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLTRA 244
            Y     ++ Y +T  V  F+ PF +M+ AY  I  T +++A ++         + L RA
Sbjct: 182 TYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQI---------QMLQRA 232

Query: 245 GLRRLQRQQQVSVD----LSFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGS 300
           G     R Q         +  +TKA  T+ I+   F LCW P  V +++  F      G 
Sbjct: 233 GASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQ 292

Query: 301 SFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREACIELL 339
            +    T  LWL Y+ S  NP +Y +  K FR A + +L
Sbjct: 293 VW----TAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL 327


>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
          Length = 387

 Score =  118 bits (295), Expect = 1e-26
 Identities = 88/339 (25%), Positives = 156/339 (46%), Gaps = 30/339 (8%)

Query: 16  LNTSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLAT 75
           L+ + +S+ G   +   + ++    ++LM ++G L   V+  + + R   +   N  + +
Sbjct: 4   LDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNL--LVMVAVCWDRQLRKIKTNYFIVS 61

Query: 76  LAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLI 135
           LAF+D+++S+  MPF A+ L+   W +G+ FC +  +L        +  L  IS+DR+  
Sbjct: 62  LAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYA 121

Query: 136 I----VQRQDKLNPRRAKVIIAVSWVL-SFCIAGPSLTGWT------LVEVPARAPQCVL 184
           I    +  ++K+ P R  +++   WV+ +F    P + GW       L+E          
Sbjct: 122 ICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNS 181

Query: 185 GYTELPADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLTRA 244
            Y     ++ Y +T  V  F+ PF +M+ AY  I  T +++A ++         + L RA
Sbjct: 182 TYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQI---------QMLQRA 232

Query: 245 GLRRLQRQQQVSVD----LSFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGS 300
           G     R Q         +  +TKA  T+ I+   F LCW P  V +++  F      G 
Sbjct: 233 GASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQ 292

Query: 301 SFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREACIELL 339
            +    T  LWL Y+ S  NP +Y +  K FR A + +L
Sbjct: 293 VW----TAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL 327


>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
          Length = 378

 Score =  118 bits (295), Expect = 1e-26
 Identities = 88/339 (25%), Positives = 156/339 (46%), Gaps = 30/339 (8%)

Query: 16  LNTSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLAT 75
           L+ + +S+ G   +   + ++    ++LM ++G L   V+  + + R   +   N  + +
Sbjct: 4   LDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNL--LVMVAVCWDRQLRKIKTNYFIVS 61

Query: 76  LAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLI 135
           LAF+D+++S+  MPF A+ L+   W +G+ FC +  +L        +  L  IS+DR+  
Sbjct: 62  LAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYA 121

Query: 136 I----VQRQDKLNPRRAKVIIAVSWVL-SFCIAGPSLTGWT------LVEVPARAPQCVL 184
           I    +  ++K+ P R  +++   WV+ +F    P + GW       L+E          
Sbjct: 122 ICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNS 181

Query: 185 GYTELPADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLTRA 244
            Y     ++ Y +T  V  F+ PF +M+ AY  I  T +++A ++         + L RA
Sbjct: 182 TYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQI---------QMLQRA 232

Query: 245 GLRRLQRQQQVSVD----LSFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGS 300
           G     R Q         +  +TKA  T+ I+   F LCW P  V +++  F      G 
Sbjct: 233 GASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQ 292

Query: 301 SFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREACIELL 339
            +    T  LWL Y+ S  NP +Y +  K FR A + +L
Sbjct: 293 VW----TAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL 327


>gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]
          Length = 388

 Score =  118 bits (295), Expect = 1e-26
 Identities = 88/339 (25%), Positives = 156/339 (46%), Gaps = 30/339 (8%)

Query: 16  LNTSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLAT 75
           L+ + +S+ G   +   + ++    ++LM ++G L   V+  + + R   +   N  + +
Sbjct: 4   LDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNL--LVMVAVCWDRQLRKIKTNYFIVS 61

Query: 76  LAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLI 135
           LAF+D+++S+  MPF A+ L+   W +G+ FC +  +L        +  L  IS+DR+  
Sbjct: 62  LAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYA 121

Query: 136 I----VQRQDKLNPRRAKVIIAVSWVL-SFCIAGPSLTGWT------LVEVPARAPQCVL 184
           I    +  ++K+ P R  +++   WV+ +F    P + GW       L+E          
Sbjct: 122 ICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNS 181

Query: 185 GYTELPADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLTRA 244
            Y     ++ Y +T  V  F+ PF +M+ AY  I  T +++A ++         + L RA
Sbjct: 182 TYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQI---------QMLQRA 232

Query: 245 GLRRLQRQQQVSVD----LSFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGS 300
           G     R Q         +  +TKA  T+ I+   F LCW P  V +++  F      G 
Sbjct: 233 GASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQ 292

Query: 301 SFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREACIELL 339
            +    T  LWL Y+ S  NP +Y +  K FR A + +L
Sbjct: 293 VW----TAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL 327


>gi|157426873 tachykinin receptor 2 [Homo sapiens]
          Length = 398

 Score =  117 bits (293), Expect = 2e-26
 Identities = 80/318 (25%), Positives = 141/318 (44%), Gaps = 24/318 (7%)

Query: 19  SNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLATLAF 78
           SN +   +  +P+      A   L + +V   GN +V  I+     MR+  N  +  LA 
Sbjct: 18  SNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLAL 77

Query: 79  SDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLIIVQ 138
           +D+ ++     F  V      W+FG  FC          +   +  +  I+ DR++ IV 
Sbjct: 78  ADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVH 137

Query: 139 R-QDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAPQCVLGYTELPADRA--- 194
             Q +L+    K +IA  W+++  +A P    ++ V +   A +CV+ + E    +    
Sbjct: 138 PFQPRLSAPSTKAVIAGIWLVALALASPQCF-YSTVTMDQGATKCVVAWPEDSGGKTLLL 196

Query: 195 YVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLTRAGLRRLQRQQQ 254
           Y + ++  ++F P  VM  AY  I  T+ + AV  H         Q   A LR LQ  + 
Sbjct: 197 YHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGH---------QAHGANLRHLQAMK- 246

Query: 255 VSVDLSFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGSSFYATSTCVLWLSY 314
                    K   T++++ + F++CWLP+ +Y +L  F +  YC          + WL+ 
Sbjct: 247 ---------KFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAM 297

Query: 315 LKSVFNPIVYCWRIKKFR 332
             +++NPI+YC    +FR
Sbjct: 298 SSTMYNPIIYCCLNHRFR 315


>gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens]
          Length = 402

 Score =  112 bits (281), Expect = 4e-25
 Identities = 89/353 (25%), Positives = 159/353 (45%), Gaps = 44/353 (12%)

Query: 16  LNTSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLAT 75
           L+ + +S+ G   +   + ++    ++LM ++G L   V+  + + R   +   N  + +
Sbjct: 4   LDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNL--LVMVAVCWDRQLRKIKTNYFIVS 61

Query: 76  LAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLI 135
           LAF+D+++S+  MPF A+ L+   W +G+ FC +  +L        +  L  IS+DR+  
Sbjct: 62  LAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYA 121

Query: 136 I----VQRQDKLNPRRAKVIIAVSWVL-SFCIAGPSLTGWTLVEV--PARAPQCVLG--- 185
           I    +  ++K+ P R  +++   WV+ +F    P + GW  + +    R+    LG   
Sbjct: 122 ICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLERSLNQGLGQDF 181

Query: 186 ---------------YTELPADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVH 230
                          Y     ++ Y +T  V  F+ PF +M+ AY  I  T +++A ++ 
Sbjct: 182 HAIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQI- 240

Query: 231 NQSDSLDLRQLTRAGLRRLQRQQQVSVD----LSFKTKAFTTILILFVGFSLCWLPHSVY 286
                   + L RAG     R Q         +  +TKA  T+ I+   F LCW P  V 
Sbjct: 241 --------QMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVT 292

Query: 287 SLLSVFSQRFYCGSSFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREACIELL 339
           +++  F      G  +    T  LWL Y+ S  NP +Y +  K FR A + +L
Sbjct: 293 NIVDPFIDYTVPGQVW----TAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL 341


>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
          Length = 455

 Score =  110 bits (274), Expect = 3e-24
 Identities = 95/342 (27%), Positives = 158/342 (46%), Gaps = 35/342 (10%)

Query: 18  TSNASDSGS-TQLPAPLRISLAIVMLL----MTVVGFLGNTVVCIIVYQRPAMRSAINLL 72
           + NASDS + TQ PAP+ IS AI++ +    + + G LGN +V + V     + S  +  
Sbjct: 5   SGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYY 64

Query: 73  LATLAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDR 132
           +  LA +D++L+   +PF+A+  +   W FG  FC + A +        +  L IIS+DR
Sbjct: 65  IVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDR 124

Query: 133 FLII---VQRQDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAPQCVLGYTEL 189
           ++ +   ++    +  RR  + +   W LS  I+   L GW     PA   + +    E 
Sbjct: 125 YIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGW---RQPAPEDETICQINEE 181

Query: 190 PADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRK---NAVRVHNQSDSLDLRQLT---- 242
           P    YV+   +  F+ P  ++L  Y C +  V K     ++   ++D  D  Q+T    
Sbjct: 182 P---GYVLFSALGSFYLPLAIILVMY-CRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIH 237

Query: 243 -------RAGLRRLQRQQQVSVDL---SFKTKAFTTILILFVGFSLCWLPHSVYSLLSVF 292
                   +G+   + +   SV L   S + KA  T+ I+   F LCWLP  +   +  F
Sbjct: 238 RKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSF 297

Query: 293 SQRFYCGSSFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREA 334
              F    + +     V WL YL S  NPI+Y    ++F++A
Sbjct: 298 FPDFKPSETVF---KIVFWLGYLNSCINPIIYPCSSQEFKKA 336


>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
          Length = 466

 Score =  110 bits (274), Expect = 3e-24
 Identities = 95/342 (27%), Positives = 158/342 (46%), Gaps = 35/342 (10%)

Query: 18  TSNASDSGS-TQLPAPLRISLAIVMLL----MTVVGFLGNTVVCIIVYQRPAMRSAINLL 72
           + NASDS + TQ PAP+ IS AI++ +    + + G LGN +V + V     + S  +  
Sbjct: 5   SGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYY 64

Query: 73  LATLAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDR 132
           +  LA +D++L+   +PF+A+  +   W FG  FC + A +        +  L IIS+DR
Sbjct: 65  IVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDR 124

Query: 133 FLII---VQRQDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAPQCVLGYTEL 189
           ++ +   ++    +  RR  + +   W LS  I+   L GW     PA   + +    E 
Sbjct: 125 YIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGW---RQPAPEDETICQINEE 181

Query: 190 PADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRK---NAVRVHNQSDSLDLRQLT---- 242
           P    YV+   +  F+ P  ++L  Y C +  V K     ++   ++D  D  Q+T    
Sbjct: 182 P---GYVLFSALGSFYLPLAIILVMY-CRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIH 237

Query: 243 -------RAGLRRLQRQQQVSVDL---SFKTKAFTTILILFVGFSLCWLPHSVYSLLSVF 292
                   +G+   + +   SV L   S + KA  T+ I+   F LCWLP  +   +  F
Sbjct: 238 RKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSF 297

Query: 293 SQRFYCGSSFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREA 334
              F    + +     V WL YL S  NPI+Y    ++F++A
Sbjct: 298 FPDFKPSETVF---KIVFWLGYLNSCINPIIYPCSSQEFKKA 336


>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
          Length = 475

 Score =  110 bits (274), Expect = 3e-24
 Identities = 95/342 (27%), Positives = 158/342 (46%), Gaps = 35/342 (10%)

Query: 18  TSNASDSGS-TQLPAPLRISLAIVMLL----MTVVGFLGNTVVCIIVYQRPAMRSAINLL 72
           + NASDS + TQ PAP+ IS AI++ +    + + G LGN +V + V     + S  +  
Sbjct: 5   SGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYY 64

Query: 73  LATLAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDR 132
           +  LA +D++L+   +PF+A+  +   W FG  FC + A +        +  L IIS+DR
Sbjct: 65  IVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDR 124

Query: 133 FLII---VQRQDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAPQCVLGYTEL 189
           ++ +   ++    +  RR  + +   W LS  I+   L GW     PA   + +    E 
Sbjct: 125 YIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGW---RQPAPEDETICQINEE 181

Query: 190 PADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRK---NAVRVHNQSDSLDLRQLT---- 242
           P    YV+   +  F+ P  ++L  Y C +  V K     ++   ++D  D  Q+T    
Sbjct: 182 P---GYVLFSALGSFYLPLAIILVMY-CRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIH 237

Query: 243 -------RAGLRRLQRQQQVSVDL---SFKTKAFTTILILFVGFSLCWLPHSVYSLLSVF 292
                   +G+   + +   SV L   S + KA  T+ I+   F LCWLP  +   +  F
Sbjct: 238 RKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSF 297

Query: 293 SQRFYCGSSFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREA 334
              F    + +     V WL YL S  NPI+Y    ++F++A
Sbjct: 298 FPDFKPSETVF---KIVFWLGYLNSCINPIIYPCSSQEFKKA 336


>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
          Length = 429

 Score =  110 bits (274), Expect = 3e-24
 Identities = 95/342 (27%), Positives = 158/342 (46%), Gaps = 35/342 (10%)

Query: 18  TSNASDSGS-TQLPAPLRISLAIVMLL----MTVVGFLGNTVVCIIVYQRPAMRSAINLL 72
           + NASDS + TQ PAP+ IS AI++ +    + + G LGN +V + V     + S  +  
Sbjct: 5   SGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYY 64

Query: 73  LATLAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDR 132
           +  LA +D++L+   +PF+A+  +   W FG  FC + A +        +  L IIS+DR
Sbjct: 65  IVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDR 124

Query: 133 FLII---VQRQDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAPQCVLGYTEL 189
           ++ +   ++    +  RR  + +   W LS  I+   L GW     PA   + +    E 
Sbjct: 125 YIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGW---RQPAPEDETICQINEE 181

Query: 190 PADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRK---NAVRVHNQSDSLDLRQLT---- 242
           P    YV+   +  F+ P  ++L  Y C +  V K     ++   ++D  D  Q+T    
Sbjct: 182 P---GYVLFSALGSFYLPLAIILVMY-CRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIH 237

Query: 243 -------RAGLRRLQRQQQVSVDL---SFKTKAFTTILILFVGFSLCWLPHSVYSLLSVF 292
                   +G+   + +   SV L   S + KA  T+ I+   F LCWLP  +   +  F
Sbjct: 238 RKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSF 297

Query: 293 SQRFYCGSSFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREA 334
              F    + +     V WL YL S  NPI+Y    ++F++A
Sbjct: 298 FPDFKPSETVF---KIVFWLGYLNSCINPIIYPCSSQEFKKA 336


>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
          Length = 432

 Score =  109 bits (273), Expect = 3e-24
 Identities = 97/337 (28%), Positives = 156/337 (46%), Gaps = 49/337 (14%)

Query: 34  RISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLATLAFSDIMLSLCCMPFTAV 93
           ++ +  ++ L+T++   GN +V I V     +R   N L+ +LA +D+ +++  MPF +V
Sbjct: 81  KVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSV 140

Query: 94  T-LITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLIIVQ------RQDKLNPR 146
           T LI  +W FG  FC +   +        +  L +IS+DR+L I +      RQ+     
Sbjct: 141 TDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQN--GKC 198

Query: 147 RAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAPQCVLGYTELPADRAYVVTLVVAVFFA 206
            AK+I++V W+LS  I  P L GW       +   C++       D  Y +      F+ 
Sbjct: 199 MAKMILSV-WLLSASITLPPLFGWAQNVNDDKV--CLIS-----QDFGYTIYSTAVAFYI 250

Query: 207 PFGVMLCAYMCILNTVRKNAVR------VHNQSDSLDLRQLTRAGLRRLQRQQQVSVDLS 260
           P  VML  Y  I    RK+A +         + DS+    +   G+ +LQ++ +   +LS
Sbjct: 251 PMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSV----IALNGIVKLQKEVEECANLS 306

Query: 261 ------------FK--TKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGSSFYATS 306
                       FK   KA TT+ I+   F++CWLP   + LLS  ++ F CG+S     
Sbjct: 307 RLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLP---FFLLST-ARPFICGTSCSCIP 362

Query: 307 TCV----LWLSYLKSVFNPIVYCWRIKKFREACIELL 339
             V    LWL Y  S+ NP +Y +  +  R     LL
Sbjct: 363 LWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLL 399


>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
          Length = 479

 Score =  109 bits (273), Expect = 3e-24
 Identities = 97/337 (28%), Positives = 156/337 (46%), Gaps = 49/337 (14%)

Query: 34  RISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLATLAFSDIMLSLCCMPFTAV 93
           ++ +  ++ L+T++   GN +V I V     +R   N L+ +LA +D+ +++  MPF +V
Sbjct: 81  KVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSV 140

Query: 94  T-LITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLIIVQ------RQDKLNPR 146
           T LI  +W FG  FC +   +        +  L +IS+DR+L I +      RQ+     
Sbjct: 141 TDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQN--GKC 198

Query: 147 RAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAPQCVLGYTELPADRAYVVTLVVAVFFA 206
            AK+I++V W+LS  I  P L GW       +   C++       D  Y +      F+ 
Sbjct: 199 MAKMILSV-WLLSASITLPPLFGWAQNVNDDKV--CLIS-----QDFGYTIYSTAVAFYI 250

Query: 207 PFGVMLCAYMCILNTVRKNAVR------VHNQSDSLDLRQLTRAGLRRLQRQQQVSVDLS 260
           P  VML  Y  I    RK+A +         + DS+    +   G+ +LQ++ +   +LS
Sbjct: 251 PMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSV----IALNGIVKLQKEVEECANLS 306

Query: 261 ------------FK--TKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGSSFYATS 306
                       FK   KA TT+ I+   F++CWLP   + LLS  ++ F CG+S     
Sbjct: 307 RLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLP---FFLLST-ARPFICGTSCSCIP 362

Query: 307 TCV----LWLSYLKSVFNPIVYCWRIKKFREACIELL 339
             V    LWL Y  S+ NP +Y +  +  R     LL
Sbjct: 363 LWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLL 399


>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
          Length = 445

 Score =  109 bits (273), Expect = 3e-24
 Identities = 97/337 (28%), Positives = 156/337 (46%), Gaps = 49/337 (14%)

Query: 34  RISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLATLAFSDIMLSLCCMPFTAV 93
           ++ +  ++ L+T++   GN +V I V     +R   N L+ +LA +D+ +++  MPF +V
Sbjct: 81  KVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSV 140

Query: 94  T-LITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLIIVQ------RQDKLNPR 146
           T LI  +W FG  FC +   +        +  L +IS+DR+L I +      RQ+     
Sbjct: 141 TDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQN--GKC 198

Query: 147 RAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAPQCVLGYTELPADRAYVVTLVVAVFFA 206
            AK+I++V W+LS  I  P L GW       +   C++       D  Y +      F+ 
Sbjct: 199 MAKMILSV-WLLSASITLPPLFGWAQNVNDDKV--CLIS-----QDFGYTIYSTAVAFYI 250

Query: 207 PFGVMLCAYMCILNTVRKNAVR------VHNQSDSLDLRQLTRAGLRRLQRQQQVSVDLS 260
           P  VML  Y  I    RK+A +         + DS+    +   G+ +LQ++ +   +LS
Sbjct: 251 PMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSV----IALNGIVKLQKEVEECANLS 306

Query: 261 ------------FK--TKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGSSFYATS 306
                       FK   KA TT+ I+   F++CWLP   + LLS  ++ F CG+S     
Sbjct: 307 RLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLP---FFLLST-ARPFICGTSCSCIP 362

Query: 307 TCV----LWLSYLKSVFNPIVYCWRIKKFREACIELL 339
             V    LWL Y  S+ NP +Y +  +  R     LL
Sbjct: 363 LWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLL 399


>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
          Length = 413

 Score =  107 bits (267), Expect = 2e-23
 Identities = 82/338 (24%), Positives = 149/338 (44%), Gaps = 27/338 (7%)

Query: 17  NTSNASDSGSTQLPAPLRI-SLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLAT 75
           N S+A D   TQ    + +  + IVM L+ +    GN +V   + +   +++  N  + +
Sbjct: 15  NRSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITS 74

Query: 76  LAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLI 135
           LA +D+++ L  +PF A  ++   W FG+ +C    ++    V   +  L +I+VDR+  
Sbjct: 75  LACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFA 134

Query: 136 IV---QRQDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAPQCVLGYT--ELP 190
           I    + Q  L   +A+VII + W++S   +   +           A  C    T  +  
Sbjct: 135 ITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFF 194

Query: 191 ADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLTRA------ 244
            ++AY +   +  F+ P  +M+  Y  +    ++   ++        ++ L++       
Sbjct: 195 TNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRT 254

Query: 245 --GLRRLQRQQQVSVDLSFKT-KAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGSS 301
             GLRR       S     K  KA  T+ I+   F+LCWLP  + +++ V          
Sbjct: 255 GHGLRR-------SSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEV 307

Query: 302 FYATSTCVLWLSYLKSVFNPIVYCWRIKKFREACIELL 339
           +   +    W+ Y+ S FNP++YC R   FR A  ELL
Sbjct: 308 YILLN----WIGYVNSGFNPLIYC-RSPDFRIAFQELL 340


>gi|62865887 G protein-coupled receptor 54 [Homo sapiens]
          Length = 398

 Score =  106 bits (265), Expect = 3e-23
 Identities = 89/347 (25%), Positives = 149/347 (42%), Gaps = 33/347 (9%)

Query: 19  SNASDSGSTQLPAPLRISLAIVMLL---MTVVGFLGNTVVCIIVYQRPAMRSAINLLLAT 75
           +NASD     +P+P  +   +V L    + ++G +GN++V  ++ +   MR+  N  +A 
Sbjct: 27  ANASDG---PVPSPRAVDAWLVPLFFAALMLLGLVGNSLVIYVICRHKPMRTVTNFYIAN 83

Query: 76  LAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLI 135
           LA +D+   LCC+PFTA+      W  GD  C+    +    V    A L  +SVDR+ +
Sbjct: 84  LAATDVTFLLCCVPFTALLYPLPGWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYV 143

Query: 136 IVQRQDKLNPRRAKVIIAVS---WVLSFCIAGPSLTGWTLVEVPARAPQCVLGYTELPAD 192
            V     L+ R  ++ +AVS   WV S  ++ P L    L   P     C   +     +
Sbjct: 144 TVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLALHRL--SPGPRAYCSEAFPSRALE 201

Query: 193 RAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLT-RAGLRRLQR 251
           RA+ +  ++A++  P       Y  +L  + + AVR      +L  + L  RAG      
Sbjct: 202 RAFALYNLLALYLLPLLATCACYAAMLRHLGRVAVRPAPADSALQGQVLAERAG------ 255

Query: 252 QQQVSVDLSFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGSSFYATSTCVLW 311
                   + + K    +  + + F+ CW P  ++ +L             YA      W
Sbjct: 256 --------AVRAKVSRLVAAVVLLFAACWGPIQLFLVLQALGPAGSWHPRSYAAYALKTW 307

Query: 312 ---LSYLKSVFNPIVYCWRIKKFREACIELLPQTFQILPKVPERIRR 355
              +SY  S  NP++Y +    FR+A   + P      P+ P R RR
Sbjct: 308 AHCMSYSNSALNPLLYAFLGSHFRQAFRRVCP----CAPRRPRRPRR 350


>gi|4507343 tachykinin receptor 1 isoform long [Homo sapiens]
          Length = 407

 Score =  103 bits (258), Expect = 2e-22
 Identities = 75/319 (23%), Positives = 140/319 (43%), Gaps = 25/319 (7%)

Query: 18  TSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLATLA 77
           ++N S+      PA   +  A    ++ V   +GN VV  I+     MR+  N  L  LA
Sbjct: 16  STNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLA 75

Query: 78  FSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLIIV 137
           F++  ++           +   W++G  +C+         V   +  +  ++ DR++ I+
Sbjct: 76  FAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAII 135

Query: 138 QR-QDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAPQCVLGYTELPA---DR 193
              Q +L+    KV+I V WVL+  +A P     T   +P+R   C++ + E P    ++
Sbjct: 136 HPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVV-CMIEWPEHPNKIYEK 194

Query: 194 AYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLTRAGLRRLQRQQ 253
            Y + + V ++F P  V+  AY  +  T+  + +      DS D            +  +
Sbjct: 195 VYHICVTVLIYFLPLLVIGYAYTVVGITLWASEI----PGDSSD------------RYHE 238

Query: 254 QVSVDLSFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGSSFYATSTCVLWLS 313
           QVS     K K    ++++   F++CWLP  ++ LL   +   Y           ++WL+
Sbjct: 239 QVSA----KRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLA 294

Query: 314 YLKSVFNPIVYCWRIKKFR 332
              +++NPI+YC    +FR
Sbjct: 295 MSSTMYNPIIYCCLNDRFR 313


>gi|4505445 neuropeptide Y receptor Y1 [Homo sapiens]
          Length = 384

 Score =  102 bits (255), Expect = 4e-22
 Identities = 76/323 (23%), Positives = 151/323 (46%), Gaps = 32/323 (9%)

Query: 21  ASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLATLAFSD 80
           A ++    LP  +  +LA+    + ++G  GN  + II+ ++  MR+  N+L+  L+FSD
Sbjct: 27  AFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSD 86

Query: 81  IMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRF-LIIVQR 139
           +++++ C+PFT V  +   W FG+  C+L+  +    +   +  L++I+V+R  LII  R
Sbjct: 87  LLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPR 146

Query: 140 QDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVEVPAR------APQCVLGYTELPADR 193
             + N R A V IAV WVL+   + P L    + + P +           + + + P+D 
Sbjct: 147 GWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDS 206

Query: 194 ---AYVVTLVVAVFFAPF-GVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLTRAGLRRL 249
              +Y   L+V  +F P   + +C +   +   R+N     N  D +      R    R 
Sbjct: 207 HRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRN-----NMMDKM------RDNKYRS 255

Query: 250 QRQQQVSVDLSFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGSSFYATSTCV 309
              +++++           +L + V F++CWLP ++++ +  ++ +     +        
Sbjct: 256 SETKRINI----------MLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLC 305

Query: 310 LWLSYLKSVFNPIVYCWRIKKFR 332
              + + +  NPI Y +  K F+
Sbjct: 306 HLTAMISTCVNPIFYGFLNKNFQ 328


>gi|7669546 tachykinin receptor 1 isoform short [Homo sapiens]
          Length = 311

 Score =  102 bits (253), Expect = 7e-22
 Identities = 73/312 (23%), Positives = 137/312 (43%), Gaps = 25/312 (8%)

Query: 18  TSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLATLA 77
           ++N S+      PA   +  A    ++ V   +GN VV  I+     MR+  N  L  LA
Sbjct: 16  STNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLA 75

Query: 78  FSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLIIV 137
           F++  ++           +   W++G  +C+         V   +  +  ++ DR++ I+
Sbjct: 76  FAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAII 135

Query: 138 QR-QDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAPQCVLGYTELPA---DR 193
              Q +L+    KV+I V WVL+  +A P     T   +P+R   C++ + E P    ++
Sbjct: 136 HPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVV-CMIEWPEHPNKIYEK 194

Query: 194 AYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLTRAGLRRLQRQQ 253
            Y + + V ++F P  V+  AY  +  T+  + +      DS D            +  +
Sbjct: 195 VYHICVTVLIYFLPLLVIGYAYTVVGITLWASEI----PGDSSD------------RYHE 238

Query: 254 QVSVDLSFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGSSFYATSTCVLWLS 313
           QVS     K K    ++++   F++CWLP  ++ LL   +   Y           ++WL+
Sbjct: 239 QVSA----KRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLA 294

Query: 314 YLKSVFNPIVYC 325
              +++NPI+YC
Sbjct: 295 MSSTMYNPIIYC 306


>gi|7669548 tachykinin receptor 3 [Homo sapiens]
          Length = 465

 Score =  102 bits (253), Expect = 7e-22
 Identities = 72/295 (24%), Positives = 127/295 (43%), Gaps = 29/295 (9%)

Query: 43  LMTVVGFLGNTVVCIIVYQRPAMRSAINLLLATLAFSDIMLSLCCMPFTAVTLITVRWHF 102
           ++  V  LGN +V  I+     MR+  N  L  LAFSD  ++        +  +   W+F
Sbjct: 94  VVVAVAVLGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYF 153

Query: 103 GDHFCRLSATLYWFFVLEGVAILLIISVDRFLIIVQRQDKLNPRRA----KVIIAVSWVL 158
           G ++CR         V   +  +  I+VDR++ I+   D L PR +    K++I   W+L
Sbjct: 154 GANYCRFQNFFPITAVFASIYSMTAIAVDRYMAII---DPLKPRLSATATKIVIGSIWIL 210

Query: 159 SFCIAGPSLTGWTLVEVPARAPQCVLGYTELPADR-AYVVTLVVAVFFAPFGVMLCAYMC 217
           +F +A P         +P R   C + + E P     Y + +++ V+  P  +M   Y  
Sbjct: 211 AFLLAFPQCLYSKTKVMPGRT-LCFVQWPEGPKQHFTYHIIVIILVYCFPLLIMGITYTI 269

Query: 218 ILNTVRKNAVRVHNQSDSLDLRQLTRAGLRRLQRQQQVSVDLSFKTKAFTTILILFVGFS 277
           +  T+    +      D+ D                +    L  K K    ++I+ + F+
Sbjct: 270 VGITLWGGEI----PGDTCD----------------KYHEQLKAKRKVVKMMIIVVMTFA 309

Query: 278 LCWLPHSVYSLLSVFSQRFYCGSSFYATSTCVLWLSYLKSVFNPIVYCWRIKKFR 332
           +CWLP+ +Y +L+   Q+               WL+   +++NPI+YC   K+FR
Sbjct: 310 ICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFR 364


>gi|4503383 dopamine receptor D1 [Homo sapiens]
          Length = 446

 Score =  101 bits (252), Expect = 9e-22
 Identities = 97/356 (27%), Positives = 156/356 (43%), Gaps = 34/356 (9%)

Query: 16  LNTSNASDSGST-QLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAI-NLLL 73
           LNTS    +G   +    +RI  A  + L+ +   LGNT+VC  V +   +RS + N  +
Sbjct: 4   LNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFV 63

Query: 74  ATLAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRF 133
            +LA SD+++++  MP+ AV  I   W FG  FC +            +  L +ISVDR+
Sbjct: 64  ISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRY 122

Query: 134 LII---VQRQDKLNPRRAKVIIAVSWVLSFCIAG-PSLTGWTLVE--VPARAPQCVLGYT 187
             I    + + K+ P+ A ++I+V+W LS  I+  P    W   +   P+      L  T
Sbjct: 123 WAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAET 182

Query: 188 ----ELPADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRV----HNQSDSLDLR 239
               +    R Y ++  V  F+ P  +M+  Y  I    +K   R+         + + +
Sbjct: 183 IDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQ 242

Query: 240 QLTRAGLRRLQRQQQVSVDLSFK--TKAFTTILILFVGFSLCWLPHSVYSLLSVF----- 292
             T  G      Q + S  +SFK  TK   T+ ++   F  CWLP  + + +  F     
Sbjct: 243 TTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGE 302

Query: 293 SQRFYCGSSFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREA------CIELLPQT 342
           +Q F   S+   T    +W  +  S  NPI+Y +    FR+A      C  L P T
Sbjct: 303 TQPFCIDSN---TFDVFVWFGWANSSLNPIIYAFN-ADFRKAFSTLLGCYRLCPAT 354


>gi|4758474 G protein-coupled receptor 10 [Homo sapiens]
          Length = 370

 Score =  100 bits (250), Expect = 2e-21
 Identities = 82/318 (25%), Positives = 140/318 (44%), Gaps = 23/318 (7%)

Query: 26  STQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLATLAFSDIMLSL 85
           S QL   L+  + ++  ++ VVG +GN ++ +++ +   + +  N L+  LA SD+++  
Sbjct: 52  SLQLVHQLKGLIVLLYSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCT 111

Query: 86  CCMPFTAVTLITVR-WHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLIIVQ-RQDKL 143
            C+P T       R W FG   C L   L    V   V  L  I+VDR++++V   + ++
Sbjct: 112 ACVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRI 171

Query: 144 NPRRAKVIIAVSWVLSFCIAGPSLTGWTLVEV-PARAPQCVLGYTELPADR-AYVVTLVV 201
           + R +   +   W LS  +A P+      VE+ P     C   +      R  Y   L++
Sbjct: 172 SLRLSAYAVLAIWALSAVLALPAAVHTYHVELKPHDVRLCEEFWGSQERQRQLYAWGLLL 231

Query: 202 AVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLTRAGLRRLQRQQQVSVDLSF 261
             +  P  V+L +Y           VRV     S+ LR     G      Q Q   D + 
Sbjct: 232 VTYLLPLLVILLSY-----------VRV-----SVKLRNRVVPG---CVTQSQADWDRAR 272

Query: 262 KTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGSSFYATSTCVLWLSYLKSVFNP 321
           + + F  ++++ V F++CWLP  V++LL           +F        WL+   + +NP
Sbjct: 273 RRRTFCLLVVVVVVFAVCWLPLHVFNLLRDLDPHAIDPYAFGLVQLLCHWLAMSSACYNP 332

Query: 322 IVYCWRIKKFREACIELL 339
            +Y W    FRE   +LL
Sbjct: 333 FIYAWLHDSFREELRKLL 350


>gi|11545887 neuropeptide FF receptor 1 [Homo sapiens]
          Length = 430

 Score = 99.4 bits (246), Expect = 5e-21
 Identities = 85/345 (24%), Positives = 146/345 (42%), Gaps = 41/345 (11%)

Query: 4   NSTSLEAYTYLLLNTSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRP 63
           N T+ EA        +N + S   Q  +P+     +   L+ ++  +GNT+VC IV +  
Sbjct: 18  NGTNTEATP-----ATNLTFSSYYQHTSPVAAMFIVAYALIFLLCMVGNTLVCFIVLKNR 72

Query: 64  AMRSAINLLLATLAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVA 123
            M +  N+ +  LA SD+++ + CMP T V  +   W F +  C++S  +    V   V 
Sbjct: 73  HMHTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVF 132

Query: 124 ILLIISVDRFLIIVQR-QDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVE------VP 176
            L+ I+V+RF  IV   ++KL  R+A V IAV W L+  I  PS    T+        V 
Sbjct: 133 TLVAIAVERFRCIVHPFREKLTLRKALVTIAVIWALALLIMCPSAVTLTVTREEHHFMVD 192

Query: 177 AR-----APQCVLGYTELPADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHN 231
           AR        C   + E    R Y   L   ++ AP  +++  Y  I   + +       
Sbjct: 193 ARNRSYPLYSCWEAWPEKGMRRVYTTVLFSHIYLAPLALIVVMYARIARKLCQAPGPAPG 252

Query: 232 QSDSLDLRQLTRAGLRRLQRQQQVSVDLSFKTKAFTTILILFVGFSLCWLPHSVYSLLSV 291
             ++ D R   R                  + +    ++++ + F+L WLP  +++LL +
Sbjct: 253 GEEAADPRASRR------------------RARVVHMLVMVALFFTLSWLP--LWALLLL 292

Query: 292 FSQRFYCGSSFYATSTCVL----WLSYLKSVFNPIVYCWRIKKFR 332
                      +  +        WL++  S  NPI+Y +  + FR
Sbjct: 293 IDYGQLSAPQLHLVTVYAFPFAHWLAFFNSSANPIIYGYFNENFR 337


>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
          Length = 520

 Score = 99.0 bits (245), Expect = 6e-21
 Identities = 102/385 (26%), Positives = 169/385 (43%), Gaps = 43/385 (11%)

Query: 4   NSTSLEAYTYLLLNTS----NASDSGST--QLPAPLRISLAIVMLLMTVVGFLGNTVVCI 57
           ++TS  A+   L N +    N + S ST  QL     IS+ +V+    +   +GN +V +
Sbjct: 9   HNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVIL 68

Query: 58  IVYQRPAMRSAINLLLATLAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFF 117
            V     +R+  N  +  LA +D++LS   +PF+A   +   W  G  FC + A +    
Sbjct: 69  SVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLC 128

Query: 118 VLEGVAILLIISVDRFLII---VQRQDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVE 174
               +  L  IS+DR++ +   +Q    +  R+A + +   WVLS  I+   L GW   +
Sbjct: 129 CTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGW---K 185

Query: 175 VPARAPQCVLGYTELPADRAYVVTLVVAVFFAPFGVMLCAY------------------M 216
            PA       G TE P    Y +   +  F+ P  V+L  Y                  M
Sbjct: 186 EPAPNDDKECGVTEEP---FYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVM 242

Query: 217 CILNTVRKNAVRVHNQSDSLDLRQLTRAGLRRLQRQQQVSVDL---SFKTKAFTTILILF 273
             ++  ++  +R+H+++   D    T+A  +    +  ++V L   S + KA  T+ I+ 
Sbjct: 243 KEMSNSKELTLRIHSKNFHEDTLSSTKA--KGHNPRSSIAVKLFKFSREKKAAKTLGIVV 300

Query: 274 VGFSLCWLPHSV-YSLLSVFSQRFYCGSSFYATSTCVLWLSYLKSVFNPIVYCWRIKKFR 332
             F LCWLP  +   L S+FS      + F      V WL Y  S  NPI+Y    K+F+
Sbjct: 301 GMFILCWLPFFIALPLGSLFSTLKPPDAVF----KVVFWLGYFNSCLNPIIYPCSSKEFK 356

Query: 333 EACIELLPQTFQILPKVPERIRRRI 357
            A + +L    +   +   R RRR+
Sbjct: 357 RAFVRILGCQCRGRGRRRRRRRRRL 381


>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
          Length = 397

 Score = 98.6 bits (244), Expect = 8e-21
 Identities = 70/305 (22%), Positives = 132/305 (43%), Gaps = 32/305 (10%)

Query: 34  RISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLATLAFSDIMLSLCCMPFTAV 93
           +I++ +V+ ++ ++   GN VVC+ V     +R+  N  + +LA +D++L L  +PF+A+
Sbjct: 18  KITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAI 77

Query: 94  TLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLII---VQRQDKLNPRRAKV 150
             ++ +W FG  FC +  +L        +  L +IS+DR+  +   ++    + P R  +
Sbjct: 78  YQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAI 137

Query: 151 IIAVSWVLSFCIAGPSL-TGWTLVEVPARAPQCVLGYTELPADRAYVVTLVVAVFFAPFG 209
            + + WV+S  ++  S+  GW      ++         ++  +  Y +   +  F+ P  
Sbjct: 138 SLVLIWVISITLSFLSIHLGWNSRNETSKGNH-TTSKCKVQVNEVYGLVDGLVTFYLPLL 196

Query: 210 VMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLTRAGLRRLQRQQQVSVDLSFKTKAFTTI 269
           +M   Y  I    R  A R+++      +     A +R              + KA  T+
Sbjct: 197 IMCITYYRIFKVARDQAKRINH------ISSWKAATIR--------------EHKATVTL 236

Query: 270 LILFVGFSLCWLPHSVYSLLSVFSQRFYCGSSFY--ATSTCVLWLSYLKSVFNPIVYCWR 327
             +   F +CW P+      + F  R   G           VLWL Y  S  NPI+Y   
Sbjct: 237 AAVMGAFIICWFPY-----FTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAAL 291

Query: 328 IKKFR 332
            + FR
Sbjct: 292 NRDFR 296


>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
          Length = 359

 Score = 98.6 bits (244), Expect = 8e-21
 Identities = 70/305 (22%), Positives = 132/305 (43%), Gaps = 32/305 (10%)

Query: 34  RISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLATLAFSDIMLSLCCMPFTAV 93
           +I++ +V+ ++ ++   GN VVC+ V     +R+  N  + +LA +D++L L  +PF+A+
Sbjct: 18  KITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAI 77

Query: 94  TLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLII---VQRQDKLNPRRAKV 150
             ++ +W FG  FC +  +L        +  L +IS+DR+  +   ++    + P R  +
Sbjct: 78  YQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAI 137

Query: 151 IIAVSWVLSFCIAGPSL-TGWTLVEVPARAPQCVLGYTELPADRAYVVTLVVAVFFAPFG 209
            + + WV+S  ++  S+  GW      ++         ++  +  Y +   +  F+ P  
Sbjct: 138 SLVLIWVISITLSFLSIHLGWNSRNETSKGNH-TTSKCKVQVNEVYGLVDGLVTFYLPLL 196

Query: 210 VMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLTRAGLRRLQRQQQVSVDLSFKTKAFTTI 269
           +M   Y  I    R  A R+++      +     A +R              + KA  T+
Sbjct: 197 IMCITYYRIFKVARDQAKRINH------ISSWKAATIR--------------EHKATVTL 236

Query: 270 LILFVGFSLCWLPHSVYSLLSVFSQRFYCGSSFY--ATSTCVLWLSYLKSVFNPIVYCWR 327
             +   F +CW P+      + F  R   G           VLWL Y  S  NPI+Y   
Sbjct: 237 AAVMGAFIICWFPY-----FTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAAL 291

Query: 328 IKKFR 332
            + FR
Sbjct: 292 NRDFR 296


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.331    0.139    0.436 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,360,589
Number of Sequences: 37866
Number of extensions: 489369
Number of successful extensions: 2765
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 360
Number of HSP's successfully gapped in prelim test: 227
Number of HSP's that attempted gapping in prelim test: 1656
Number of HSP's gapped (non-prelim): 786
length of query: 372
length of database: 18,247,518
effective HSP length: 104
effective length of query: 268
effective length of database: 14,309,454
effective search space: 3834933672
effective search space used: 3834933672
T: 11
A: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.9 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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